PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20930415-3 2010 The major anti-, anti-adduct (+-)-26 was converted to (+-)-digitoxose (3), while the minor anti-, syn-adduct (+-)-27 was also converted to (+-)-olivose (4). olivose 139-151 synemin Homo sapiens 98-101 21074618-4 2011 The secreted single chain murine soluble CD40L monomers, dimers, and trimers were initially enriched through histidine tag capture by Ni-Sepharose 6 fast flow resin and further purified on a cation exchange resin. Histidine 109-118 CD40 ligand Mus musculus 41-46 21359214-0 2011 Histidine hydrogen-deuterium exchange mass spectrometry for probing the microenvironment of histidine residues in dihydrofolate reductase. Histidine 0-9 Dihydrofolate reductase Escherichia coli 114-137 21359214-0 2011 Histidine hydrogen-deuterium exchange mass spectrometry for probing the microenvironment of histidine residues in dihydrofolate reductase. Histidine 92-101 Dihydrofolate reductase Escherichia coli 114-137 21359214-3 2011 His-HDX-MS was used to probe the microenvironment of histidine residues of E. coli dihydrofolate reductase (DHFR), an enzyme proposed to undergo multiple conformational changes during catalysis. Histidine 53-62 Dihydrofolate reductase Escherichia coli 83-106 21359214-3 2011 His-HDX-MS was used to probe the microenvironment of histidine residues of E. coli dihydrofolate reductase (DHFR), an enzyme proposed to undergo multiple conformational changes during catalysis. Histidine 53-62 Dihydrofolate reductase Escherichia coli 108-112 21359214-4 2011 METHODOLOGY/PRINCIPAL FINDINGS: Using His-HDX-MS, the pK(a) values and the half-lives (t(1/2)) of HDX reactions of five histidine residues of apo-DHFR, DHFR in complex with methotrexate (DHFR-MTX), DHFR in complex with MTX and NADPH (DHFR-MTX-NADPH), and DHFR in complex with folate and NADP+ (DHFR-folate-NADP+) were determined. Histidine 120-129 Dihydrofolate reductase Escherichia coli 146-150 21359214-4 2011 METHODOLOGY/PRINCIPAL FINDINGS: Using His-HDX-MS, the pK(a) values and the half-lives (t(1/2)) of HDX reactions of five histidine residues of apo-DHFR, DHFR in complex with methotrexate (DHFR-MTX), DHFR in complex with MTX and NADPH (DHFR-MTX-NADPH), and DHFR in complex with folate and NADP+ (DHFR-folate-NADP+) were determined. Histidine 120-129 Dihydrofolate reductase Escherichia coli 152-156 21359214-4 2011 METHODOLOGY/PRINCIPAL FINDINGS: Using His-HDX-MS, the pK(a) values and the half-lives (t(1/2)) of HDX reactions of five histidine residues of apo-DHFR, DHFR in complex with methotrexate (DHFR-MTX), DHFR in complex with MTX and NADPH (DHFR-MTX-NADPH), and DHFR in complex with folate and NADP+ (DHFR-folate-NADP+) were determined. Histidine 120-129 Dihydrofolate reductase Escherichia coli 152-156 21359214-4 2011 METHODOLOGY/PRINCIPAL FINDINGS: Using His-HDX-MS, the pK(a) values and the half-lives (t(1/2)) of HDX reactions of five histidine residues of apo-DHFR, DHFR in complex with methotrexate (DHFR-MTX), DHFR in complex with MTX and NADPH (DHFR-MTX-NADPH), and DHFR in complex with folate and NADP+ (DHFR-folate-NADP+) were determined. Histidine 120-129 Dihydrofolate reductase Escherichia coli 152-156 21359214-4 2011 METHODOLOGY/PRINCIPAL FINDINGS: Using His-HDX-MS, the pK(a) values and the half-lives (t(1/2)) of HDX reactions of five histidine residues of apo-DHFR, DHFR in complex with methotrexate (DHFR-MTX), DHFR in complex with MTX and NADPH (DHFR-MTX-NADPH), and DHFR in complex with folate and NADP+ (DHFR-folate-NADP+) were determined. Histidine 120-129 Dihydrofolate reductase Escherichia coli 152-156 21359214-4 2011 METHODOLOGY/PRINCIPAL FINDINGS: Using His-HDX-MS, the pK(a) values and the half-lives (t(1/2)) of HDX reactions of five histidine residues of apo-DHFR, DHFR in complex with methotrexate (DHFR-MTX), DHFR in complex with MTX and NADPH (DHFR-MTX-NADPH), and DHFR in complex with folate and NADP+ (DHFR-folate-NADP+) were determined. Histidine 120-129 Dihydrofolate reductase Escherichia coli 152-156 21359214-4 2011 METHODOLOGY/PRINCIPAL FINDINGS: Using His-HDX-MS, the pK(a) values and the half-lives (t(1/2)) of HDX reactions of five histidine residues of apo-DHFR, DHFR in complex with methotrexate (DHFR-MTX), DHFR in complex with MTX and NADPH (DHFR-MTX-NADPH), and DHFR in complex with folate and NADP+ (DHFR-folate-NADP+) were determined. Histidine 120-129 Dihydrofolate reductase Escherichia coli 152-156 21290626-0 2004 3-Cyano-4-[(18)F]fluoro-benzoyl-Arg-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2 3-Cyano-4-[(18)F]fluoro-benzoyl-Arg-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2, abbreviated as [(18)F]6b, is a bombesin (BN)-based (18)F-labeled peptide synthesized by Mu et al. Histidine 63-66 GCY Homo sapiens 67-70 21290626-0 2004 3-Cyano-4-[(18)F]fluoro-benzoyl-Arg-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2 3-Cyano-4-[(18)F]fluoro-benzoyl-Arg-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2, abbreviated as [(18)F]6b, is a bombesin (BN)-based (18)F-labeled peptide synthesized by Mu et al. Histidine 63-66 GCY Homo sapiens 146-149 21290626-0 2004 3-Cyano-4-[(18)F]fluoro-benzoyl-Arg-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2 3-Cyano-4-[(18)F]fluoro-benzoyl-Arg-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2, abbreviated as [(18)F]6b, is a bombesin (BN)-based (18)F-labeled peptide synthesized by Mu et al. Histidine 142-145 GCY Homo sapiens 67-70 21290626-0 2004 3-Cyano-4-[(18)F]fluoro-benzoyl-Arg-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2 3-Cyano-4-[(18)F]fluoro-benzoyl-Arg-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2, abbreviated as [(18)F]6b, is a bombesin (BN)-based (18)F-labeled peptide synthesized by Mu et al. Histidine 142-145 GCY Homo sapiens 146-149 21290627-0 2004 3-Cyano-4-[(18)F]fluoro-benzoyl-Ala(SO3H)-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2 3-Cyano-4-[(18)F]fluoro-benzoyl-Ala(SO3H)-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2, abbreviated as [(18)F]7b, is a bombesin (BN)-based (18)F-labeled peptide synthesized by Mu et al. Histidine 69-72 GCY Homo sapiens 73-76 21290627-0 2004 3-Cyano-4-[(18)F]fluoro-benzoyl-Ala(SO3H)-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2 3-Cyano-4-[(18)F]fluoro-benzoyl-Ala(SO3H)-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2, abbreviated as [(18)F]7b, is a bombesin (BN)-based (18)F-labeled peptide synthesized by Mu et al. Histidine 69-72 GCY Homo sapiens 158-161 21525719-7 2011 In conclusion, substitution with histidine leads to partial loss of inhibition of the mutant type I receptor through diminished binding of FKBP12, which may act as a gradient reader in morphogenetic contexts. Histidine 33-42 FKBP prolyl isomerase 1A pseudogene 4 Homo sapiens 139-145 22110750-5 2011 The data showed that SENP8 only cleaved the peptide bond beyond the di-glycine motif of CrNEDD8 and His-RUB1 was subsequently generated, confirming that SENP8 has exquisite specificity for CrNEDD8 but not CrUb. Histidine 100-103 related to ubiquitin 1 Arabidopsis thaliana 104-108 21966400-0 2011 Fibrillization of human tau is accelerated by exposure to lead via interaction with His-330 and His-362. Histidine 96-99 microtubule associated protein tau Homo sapiens 24-27 21966400-8 2011 The results from isothermal titration calorimetry show that one Pb(2+) binds to one Tau monomer via interaction with His-330 and His-362, with sub-micromolar affinity. Histidine 117-120 microtubule associated protein tau Homo sapiens 84-87 21966400-8 2011 The results from isothermal titration calorimetry show that one Pb(2+) binds to one Tau monomer via interaction with His-330 and His-362, with sub-micromolar affinity. Histidine 129-132 microtubule associated protein tau Homo sapiens 84-87 21966400-9 2011 CONCLUSIONS/SIGNIFICANCE: We demonstrate for the first time that the fibrillization of human Tau protein is accelerated by exposure to lead via interaction with His-330 and His-362. Histidine 161-164 microtubule associated protein tau Homo sapiens 93-96 21966400-9 2011 CONCLUSIONS/SIGNIFICANCE: We demonstrate for the first time that the fibrillization of human Tau protein is accelerated by exposure to lead via interaction with His-330 and His-362. Histidine 173-176 microtubule associated protein tau Homo sapiens 93-96 31273433-4 2019 We show here that the SLC30A8 gene is also inactivated in sheep, cows, chinchillas and naked mole rats but in all four species a histidine is retained at amino acid 10 in the B chain of insulin. Histidine 129-138 LOW QUALITY PROTEIN: zinc transporter 8 Ovis aries 22-29 31082440-6 2019 15N NMR spectra indicate that removal of the second histidine converted the protonation and tautomeric equilibria of H19 to be similar to the H37 behavior in AM2, indicating that the peripheral H27 is indeed the origin of the low pKa"s of H19 in wild-type BM2. Histidine 52-61 H19 imprinted maternally expressed transcript Homo sapiens 117-120 31082440-6 2019 15N NMR spectra indicate that removal of the second histidine converted the protonation and tautomeric equilibria of H19 to be similar to the H37 behavior in AM2, indicating that the peripheral H27 is indeed the origin of the low pKa"s of H19 in wild-type BM2. Histidine 52-61 adrenomedullin 2 Homo sapiens 158-161 31082440-6 2019 15N NMR spectra indicate that removal of the second histidine converted the protonation and tautomeric equilibria of H19 to be similar to the H37 behavior in AM2, indicating that the peripheral H27 is indeed the origin of the low pKa"s of H19 in wild-type BM2. Histidine 52-61 H19 imprinted maternally expressed transcript Homo sapiens 239-242 31222087-6 2019 DTA exerts its toxic activity through inhibition of eukaryotic translation elongation factor 2 (eEF2) via adenosine diphosphate (ADP)-ribosylation of a modified histidine residue, diphthamide, at His715, which blocks protein translation and leads to cell death. Histidine 161-170 eukaryotic translation elongation factor 2 Homo sapiens 52-94 31222087-6 2019 DTA exerts its toxic activity through inhibition of eukaryotic translation elongation factor 2 (eEF2) via adenosine diphosphate (ADP)-ribosylation of a modified histidine residue, diphthamide, at His715, which blocks protein translation and leads to cell death. Histidine 161-170 eukaryotic translation elongation factor 2 Homo sapiens 96-100 30992364-0 2019 Tau repeat regions contain conserved histidine residues that modulate microtubule-binding in response to changes in pH. Histidine 37-46 microtubule associated protein tau Homo sapiens 0-3 30992364-4 2019 Here, we used molecular dynamics, microtubule-binding experiments, and live-cell microscopy, revealing that highly-conserved histidine residues near the C terminus of each microtubule-binding repeat are pH sensors that can modulate tau-microtubule interaction strength within the physiological intracellular pH range. Histidine 125-134 microtubule associated protein tau Homo sapiens 232-235 30992364-7 2019 Electrostatic and hydrophobic characteristics of histidine were both required for tau-microtubule binding, as substitutions with constitutively and positively charged nonaromatic lysine or uncharged alanine greatly reduced or abolished tau-microtubule binding. Histidine 49-58 microtubule associated protein tau Homo sapiens 82-85 30992364-7 2019 Electrostatic and hydrophobic characteristics of histidine were both required for tau-microtubule binding, as substitutions with constitutively and positively charged nonaromatic lysine or uncharged alanine greatly reduced or abolished tau-microtubule binding. Histidine 49-58 microtubule associated protein tau Homo sapiens 236-239 30807919-10 2019 These results suggested that S1PC alters histidine metabolism and consequently exerts the antihypertensive effect via the central histamine H3 receptor. Histidine 41-50 histamine receptor H3 Rattus norvegicus 130-151 31133770-3 2019 These studies showed that mutation of the proximal histidine residue with both natural and non-natural amino acids result in stable myoglobin variants that can function as both carbene and nitrene transferases. Histidine 51-60 myoglobin Homo sapiens 132-141 31133770-4 2019 In addition, substitution of the proximal histidine with an aspartate residue led to a myoglobin-based catalyst capable of promoting stereoselective olefin cyclopropanation under nonreducing conditions. Histidine 42-51 myoglobin Homo sapiens 87-96 30841425-3 2019 The fusion protein His-HSP65-STEAP1 186-193 (HHST1), His-HSP65-2xSTEAP1 186-193 (HHST2) and His-HSP65-6xSTEAP1 186-193 (HHST6) were obtained by setting different copy number of STEAP1 186-193 and adding His purification tag before HSP65. Histidine 19-22 heat shock protein 1 (chaperonin) Mus musculus 23-28 30376305-4 2019 X-ray protein crystallography of the {[Pt(ppy)(PPh3)]/ubiquitin} conjugate revealed direct bonding of the platinum center to unique histidine-68 residue through the nitrogen atom of imidazole function, the coordination being also supported by noncovalent interaction of the ligands with the protein secondary structure. Histidine 132-141 protein phosphatase 4 catalytic subunit Homo sapiens 47-51 30576128-13 2019 These findings add to the understanding of [2Fe-2S] cluster nitrosylation and will help to identify DNICs resulting from the reaction of NO with Fe/S cofactors featuring alternative, proton-responsive histidine ligands such as the Rieske and mitoNEET [2Fe-2S] clusters. Histidine 201-210 CDGSH iron sulfur domain 1 Homo sapiens 242-250 31140178-7 2019 Herein, we demonstrated that nitro-oleic acid (NO2-OA) nitroalkylate alpha-syn, forming a covalent adduct at histidine-50. Histidine 109-118 synuclein alpha Homo sapiens 69-78 20876538-7 2010 The C-terminal region of DGAT1, which accounts for ~50% of the protein, is present in the endoplasmic reticulum lumen and contains a highly conserved histidine residue (His-426) that may be part of the active site. Histidine 150-159 diacylglycerol O-acyltransferase 1 Mus musculus 25-30 20876538-7 2010 The C-terminal region of DGAT1, which accounts for ~50% of the protein, is present in the endoplasmic reticulum lumen and contains a highly conserved histidine residue (His-426) that may be part of the active site. Histidine 169-172 diacylglycerol O-acyltransferase 1 Mus musculus 25-30 21085684-2 2010 Two classical PLDs, PLD1 and PLD2, contain phosphatidylinositide-binding PX and PH domains and two conserved His-x-Lys-(x)(4)-Asp (HKD) motifs, which are critical for PLD activity. Histidine 109-112 phospholipase D2 Mus musculus 29-33 21060845-5 2010 Here we report that an S. cerevisiae strain expressing the mre11-H59A allele, mutant at a conserved active site histidine, is sensitive to hydroxyurea and also to ionizing radiation, which induces DSBs, but not to CPT or ETP. Histidine 112-121 MRX complex nuclease subunit Saccharomyces cerevisiae S288C 59-64 30120407-11 2019 Brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), hepatocyte growth factor (HGF), and stromal cell-derived factor-1 (SDF-1) gene expressions in hAFS were elevated when exposed to HI-induced brain extract. Histidine 198-200 brain derived neurotrophic factor Mus musculus 0-33 30187212-3 2018 The primary sequence of prothymosin-alpha is highly acidic, with almost 50% comprised of Asp and Glu, and is unusual for a Zn2+-binding protein as it lacks Cys and His residues. Histidine 164-167 prothymosin alpha pseudogene 9 Homo sapiens 24-41 20682345-5 2010 The addition of GST, Trx or GB1 to the N-terminal His(6) tag significantly improved both the expression and solubility of target proteins as compared to His(6) tag alone. Histidine 50-53 thioredoxin Homo sapiens 21-24 20682345-5 2010 The addition of GST, Trx or GB1 to the N-terminal His(6) tag significantly improved both the expression and solubility of target proteins as compared to His(6) tag alone. Histidine 153-156 thioredoxin Homo sapiens 21-24 20718505-1 2010 Zif268 is a zinc-finger protein containing three Cys(2)-His(2)-type zinc-finger domains that bind the target DNA sequence GCGTGGGCG in a cooperative manner. Histidine 56-59 early growth response 1 Homo sapiens 0-6 30613344-3 2018 When compared with the structure of a mercaptoacetamide bound to the class I isozyme HDAC8, different interactions are observed with the conserved tandem histidine pair in the active site. Histidine 154-163 histone deacetylase 8 Homo sapiens 85-90 30187100-6 2018 A large amount of the small P particles and the trimer and dimer complexes formed by 12, 6, and 2 P monomers were observed in both the expression of the NoV P-His and P containing cysteine tag at the N-terminus. Histidine 159-162 plexin A1 Homo sapiens 153-158 30187100-7 2018 Dynamic light scattering and transmission electron microscopy analysis of the purified NoV P-His and P revealed that most of these small P particles are triangle-, square-, and ring-shaped with a diameter of 14-15 nm. Histidine 93-96 plexin A1 Homo sapiens 87-92 30335802-1 2018 In eukaryotes, the modification of an invariant histidine (His-699 in yeast) residue in translation elongation factor 2 (EF2) with diphthamide involves a conserved pathway encoded by the DPH1-DPH7 gene network. Histidine 48-57 diphthamide synthase Saccharomyces cerevisiae S288C 192-196 30335802-1 2018 In eukaryotes, the modification of an invariant histidine (His-699 in yeast) residue in translation elongation factor 2 (EF2) with diphthamide involves a conserved pathway encoded by the DPH1-DPH7 gene network. Histidine 59-62 diphthamide synthase Saccharomyces cerevisiae S288C 192-196 30207701-6 2018 Comparison of the nuCO and nuFe-C values of the heme-DNA complexes with those of myoglobin (Mb) revealed that the donor strength of the axial ligation trans to the CO in a complex is considerably weaker than that of the proximal histidine in Mb, as expected from the coordination of H2O trans to the CO in the complex. Histidine 229-238 myoglobin Homo sapiens 81-90 29902001-6 2018 The chemical modification of alpha-glucosidase verified the results of the computer simulation that the order of importance of the four amino acid residues in the binding process was His > Tyr > Lys > Arg. Histidine 183-186 sucrase-isomaltase Homo sapiens 29-46 29844495-6 2018 Structure comparisons identify a TIRR histidine (H106) that is absent from the TIRR homolog Nudt16, but essential for 53BP1 Tudor binding. Histidine 38-47 tumor protein p53 binding protein 1 Homo sapiens 118-123 20847263-5 2010 We used mass spectrometry to show that the phosphate from PEP is transferred to the catalytic histidine (His11) on human PGAM1. Histidine 94-103 phosphoglycerate mutase 1 Homo sapiens 121-126 20847263-7 2010 The presence of histidine-phosphorylated PGAM1 correlated with the expression of PKM2 in cancer cell lines and tumor tissues. Histidine 16-25 phosphoglycerate mutase 1 Homo sapiens 41-46 20847263-7 2010 The presence of histidine-phosphorylated PGAM1 correlated with the expression of PKM2 in cancer cell lines and tumor tissues. Histidine 16-25 pyruvate kinase M1/2 Homo sapiens 81-85 20847263-8 2010 Thus, decreased pyruvate kinase activity in PKM2-expressing cells allows PEP-dependent histidine phosphorylation of PGAM1 and may provide an alternate glycolytic pathway that decouples adenosine triphosphate production from PEP-mediated phosphotransfer, allowing for the high rate of glycolysis to support the anabolic metabolism observed in many proliferating cells. Histidine 87-96 pyruvate kinase M1/2 Homo sapiens 44-48 20847263-8 2010 Thus, decreased pyruvate kinase activity in PKM2-expressing cells allows PEP-dependent histidine phosphorylation of PGAM1 and may provide an alternate glycolytic pathway that decouples adenosine triphosphate production from PEP-mediated phosphotransfer, allowing for the high rate of glycolysis to support the anabolic metabolism observed in many proliferating cells. Histidine 87-96 phosphoglycerate mutase 1 Homo sapiens 116-121 20338153-15 2010 Determination of the three-dimensional structure of BChE and AChE conjugated to different OPs showed that aged adducts form a salt bridge with the protonated catalytic histidine. Histidine 168-177 butyrylcholinesterase Homo sapiens 52-56 29624837-0 2018 Two Histidines in an alpha-Helix: A Rigid Co2+ -Binding Motif for PCS Measurements by NMR Spectroscopy. Histidine 4-14 complement C2 Homo sapiens 42-45 20519567-0 2010 The role of the methionines and histidines in the transmembrane domain of mammalian copper transporter 1 in the cellular accumulation of cisplatin. Histidine 32-42 solute carrier family 31 member 1 Homo sapiens 84-104 20519567-2 2010 Methionines 150, 154, and histidine 139 have been proposed to form a series of stacked rings in the pore formed by the CTR1 homotrimer, each of which is required for maximal copper transport. Histidine 26-35 solute carrier family 31 member 1 Homo sapiens 119-123 29624837-3 2018 We show that two histidine residues in sequential turns of an alpha-helix provide a binding site for a Co2+ ion, which positions the metal ion in a uniquely well-defined and predictable location. Histidine 17-26 complement C2 Homo sapiens 103-106 20484158-9 2010 In addition, we find that His(132), Val(134), and Asn(141) in human ssTnI, previously identified as enabling contractile function during cellular acidosis, are present in all vertebrate cTnI isoforms except those from monotremes, marsupials, and eutherian mammals. Histidine 26-29 troponin I1, slow skeletal type Homo sapiens 68-73 20436286-4 2010 Mutation of conserved motif C cysteines and histidines disrupted the association of Dbf4 with ARS1 origin DNA and Mcm2, but not other known ligands including Cdc7, Rad53 or the origin recognition complex subunit Orc2. Histidine 44-54 MCM DNA helicase complex subunit MCM2 Saccharomyces cerevisiae S288C 114-118 29688719-2 2018 We demonstrate herein that the photoactive platinum(IV) anticancer complex trans,trans,trans-[Pt(N3)2(OH)2(Py)2] (1) can bind to His, Glu, and Gln residues of Trx upon the irradiation of blue light. Histidine 129-132 thioredoxin Homo sapiens 159-162 29594302-2 2018 Ir1 with a two-photon action cross-section of 40 GM in the NIR region has been developed for targeting intracellular histidine. Histidine 117-126 nischarin Homo sapiens 0-3 29594302-3 2018 Two-photon micrographs showed that Ir1 could rapidly and selectively light up the nucleus in both fixed and live cells and is capable of displaying nuclear histidine distribution in ultra-detail using a super resolution (SR) technique under stimulated emission depletion (STED) microscopy. Histidine 156-165 nischarin Homo sapiens 35-38 29642034-6 2018 Substitution of histidine at the cognate position 164 in cTnI confers the same pH insensitivity to adult cardiac myocytes. Histidine 16-25 troponin I3, cardiac type Rattus norvegicus 57-61 20351192-2 2010 An N-terminally His-tagged C1inhDelta97 variant was also produced. Histidine 16-19 heterogeneous nuclear ribonucleoprotein C Homo sapiens 27-39 20202940-5 2010 Wild-type untagged Ste14p also co-immunoprecipitated and co-purified with N-terminal-tagged His(10)-myc(3)-Ste14p (His-Ste14p). Histidine 92-95 protein-S-isoprenylcysteine carboxyl O-methyltransferase Saccharomyces cerevisiae S288C 19-25 20202940-5 2010 Wild-type untagged Ste14p also co-immunoprecipitated and co-purified with N-terminal-tagged His(10)-myc(3)-Ste14p (His-Ste14p). Histidine 92-95 protein-S-isoprenylcysteine carboxyl O-methyltransferase Saccharomyces cerevisiae S288C 107-113 20202940-5 2010 Wild-type untagged Ste14p also co-immunoprecipitated and co-purified with N-terminal-tagged His(10)-myc(3)-Ste14p (His-Ste14p). Histidine 92-95 protein-S-isoprenylcysteine carboxyl O-methyltransferase Saccharomyces cerevisiae S288C 107-113 20202940-5 2010 Wild-type untagged Ste14p also co-immunoprecipitated and co-purified with N-terminal-tagged His(10)-myc(3)-Ste14p (His-Ste14p). Histidine 115-118 protein-S-isoprenylcysteine carboxyl O-methyltransferase Saccharomyces cerevisiae S288C 19-25 20202940-5 2010 Wild-type untagged Ste14p also co-immunoprecipitated and co-purified with N-terminal-tagged His(10)-myc(3)-Ste14p (His-Ste14p). Histidine 115-118 protein-S-isoprenylcysteine carboxyl O-methyltransferase Saccharomyces cerevisiae S288C 107-113 20202940-5 2010 Wild-type untagged Ste14p also co-immunoprecipitated and co-purified with N-terminal-tagged His(10)-myc(3)-Ste14p (His-Ste14p). Histidine 115-118 protein-S-isoprenylcysteine carboxyl O-methyltransferase Saccharomyces cerevisiae S288C 107-113 29463897-0 2018 Molecular basis for histidine N1 position-specific methylation by CARNMT1. Histidine 20-29 carnosine N-methyltransferase 1 Homo sapiens 66-73 20202940-6 2010 Furthermore, enzymatically inactive His-Ste14p variants L81F and E213Q both exerted a dominant-negative effect on methyltransferase activity when co-expressed and co-purified with untagged wild-type Ste14p. Histidine 36-39 protein-S-isoprenylcysteine carboxyl O-methyltransferase Saccharomyces cerevisiae S288C 40-46 20202940-6 2010 Furthermore, enzymatically inactive His-Ste14p variants L81F and E213Q both exerted a dominant-negative effect on methyltransferase activity when co-expressed and co-purified with untagged wild-type Ste14p. Histidine 36-39 protein-S-isoprenylcysteine carboxyl O-methyltransferase Saccharomyces cerevisiae S288C 199-205 19697087-6 2010 Treatment of undeveloped ovarian explant cultures with recombinant histidine (His)-RPL10a stimulated the expression of translationally controlled tumor protein (TCTP), heat shock protein 70 (HSP70), and shrimp ovarian peritrophin (SOP) genes, previously shown to be involved in ovarian maturation. Histidine 67-76 tumor protein, translationally-controlled 1 Homo sapiens 119-159 19697087-6 2010 Treatment of undeveloped ovarian explant cultures with recombinant histidine (His)-RPL10a stimulated the expression of translationally controlled tumor protein (TCTP), heat shock protein 70 (HSP70), and shrimp ovarian peritrophin (SOP) genes, previously shown to be involved in ovarian maturation. Histidine 67-76 tumor protein, translationally-controlled 1 Homo sapiens 161-165 19697087-6 2010 Treatment of undeveloped ovarian explant cultures with recombinant histidine (His)-RPL10a stimulated the expression of translationally controlled tumor protein (TCTP), heat shock protein 70 (HSP70), and shrimp ovarian peritrophin (SOP) genes, previously shown to be involved in ovarian maturation. Histidine 78-81 tumor protein, translationally-controlled 1 Homo sapiens 119-159 19697087-6 2010 Treatment of undeveloped ovarian explant cultures with recombinant histidine (His)-RPL10a stimulated the expression of translationally controlled tumor protein (TCTP), heat shock protein 70 (HSP70), and shrimp ovarian peritrophin (SOP) genes, previously shown to be involved in ovarian maturation. Histidine 78-81 tumor protein, translationally-controlled 1 Homo sapiens 161-165 20376793-7 2010 RESULTS: A novel missense mutation, CAC to CGC, was found at codon 283 of the ABCD1 gene from the patient, resulting in the replacement of histidine by arginine. Histidine 139-148 ATP binding cassette subfamily D member 1 Homo sapiens 78-83 20029090-7 2010 Furthermore, the MVC inhibition is mediated by His-142, suggesting that this residue is protonated for maximal HDAC8 activity. Histidine 47-50 histone deacetylase 8 Homo sapiens 111-116 19933215-8 2010 In contrast to the reduced binding properties of the nonsense mutations, the only missense mutation (H363N) found in AMRF leads to increased binding of beta-GC to LIMP-2, indicating that this highly conserved histidine modifies the affinity of LIMP-2 to its ligand. Histidine 209-218 glucosylceramidase beta Homo sapiens 152-159 19933215-8 2010 In contrast to the reduced binding properties of the nonsense mutations, the only missense mutation (H363N) found in AMRF leads to increased binding of beta-GC to LIMP-2, indicating that this highly conserved histidine modifies the affinity of LIMP-2 to its ligand. Histidine 209-218 scavenger receptor class B member 2 Homo sapiens 163-169 19875381-5 2010 We further characterized a novel ADP-dependent HSP90 interaction with the cysteine- and histidine-rich domain (CHORD)-containing protein CHORDC1. Histidine 88-97 heat shock protein 90 alpha family class A member 1 Homo sapiens 47-52 19679188-3 2010 In this study, recombinant methods were used to produce substantial quantities of his-tagged recombinant mouse zeta-crystallin, which was then purified to homogeneity. Histidine 4-7 crystallin, zeta Mus musculus 111-126 29362492-2 2018 Diphthamide is the posttranslationally modified histidine residue on EEF2 that promotes protein chain elongation in the ribosome. Histidine 48-57 eukaryotic translation elongation factor 2 Homo sapiens 69-73 28911864-3 2018 The key activation event involves the rearrangement of the HAMP-DHp helical core and translation of the CA towards the acceptor histidine, which presumably results in an autokinase-competent complex. Histidine 128-137 hepcidin antimicrobial peptide Homo sapiens 59-63 29590073-3 2018 In the presence of the substrate protein, elongation factor 2, this intermediate converts to an organic radical, formed by addition of the ACP radical to a histidine side chain. Histidine 156-165 eukaryotic translation elongation factor 2 Homo sapiens 42-61 29547723-5 2018 Direct metal binding to a histidine-rich stretch in IRT1 triggers its phosphorylation by the CIPK23 kinase and facilitates the subsequent recruitment of the IDF1 E3 ligase. Histidine 26-35 allograft inflammatory factor 1 Homo sapiens 52-56 29134764-0 2018 Peptides derived from histidine and methionine-rich regions of copper transporter 1 exhibit anti-angiogenic property by chelating extracellular Cu. Histidine 22-31 solute carrier family 31 member 1 Homo sapiens 63-83 29134764-6 2018 In this study, we have designed three peptides from copper-binding regions of CTR1 which are rich in histidine and methionine. Histidine 101-110 solute carrier family 31 member 1 Homo sapiens 78-82 29020666-3 2018 Herein, we describe a simple histidine (H) conjugated perylene diimide (PDI) bolaamphiphile (HPH) as a dual-responsive optical marker to develop highly selective and sensitive probe as visible (sol-to-gel transformation), fluorescence and SERS-based Hg2+sensor platform in the water. Histidine 29-38 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 239-243 28965571-3 2017 The protein sequence analysis of hTLR4 revealed that the ectodomain, the region supposed to coordinate the metal ions, contains a histidine-rich motif that is not conserved among all organisms. Histidine 130-139 toll like receptor 4 Homo sapiens 33-38 29445441-7 2017 There was a deoxyribonucleic acid variant with transversion of alanine with tyrosine and change of histidine with leucine on notch 3 gene. Histidine 99-108 notch receptor 3 Homo sapiens 125-132 28724665-4 2017 Tumor-associated macrophages in surgical specimens and sensitivity to CSF-1R inhibitors were used to determine macrophage function.Results: A CSF1R c.1085A>G genetic variant causing the change of histidine to arginine in the domain of receptor dimerization was identified as a high allele frequency in Eastern Asian population. Histidine 199-208 colony stimulating factor 1 Homo sapiens 142-146 28805803-4 2017 PGAM1 needs to be histidine phosphorylated to become catalytically active. Histidine 18-27 phosphoglycerate mutase 1 Homo sapiens 0-5 19793363-2 2010 Since, in patients with ccTGA(SLL), an elongated His-bundle runs medially toward the upper septum to the site of the fibrous continuity between the right-sided mitral valve and pulmonary artery, the His-bundle may easily be captured by a pacing lead, unlike in normal hearts. Histidine 49-52 solute carrier family 35 member B2 Homo sapiens 30-33 19793363-2 2010 Since, in patients with ccTGA(SLL), an elongated His-bundle runs medially toward the upper septum to the site of the fibrous continuity between the right-sided mitral valve and pulmonary artery, the His-bundle may easily be captured by a pacing lead, unlike in normal hearts. Histidine 199-202 solute carrier family 35 member B2 Homo sapiens 30-33 19758826-4 2009 We propose that this newly discovered unstable M-hemoglobin (M-Hb) variant, named Hb Dothan [GGT/GAG-->GAG//Gly/Glu-->Glu], is caused by a shift in the amino acid sequence and altered packing of the B and E helices during beta globin synthesis, and also changes the orientation of the critical proximal and distal histidine in the F and E helices respectively. Histidine 314-323 hemoglobin subunit beta Homo sapiens 222-233 19875047-7 2009 The utility of this class of ligands was further demonstrated by the radiolabelling of a cyclic peptide that is known to target the serine protease receptor uPAR; essentially quantitative incorporation of (99m)Tc occurred exclusively at the SAAC site, despite the presence of a His residue, and without disruption of the disulfide bond. Histidine 278-281 plasminogen activator, urokinase receptor Homo sapiens 157-161 28882106-6 2017 By utilizing plasmid flag-p27kip1, HA-RanBP2, GST-RanBP2 and His-p27kip1 and immunoprecipitation assay, we validated that p27kip1 can serve as the sumoylation target of RanBP2 in QBC939. Histidine 61-64 cyclin dependent kinase inhibitor 1B Homo sapiens 65-72 19706593-2 2009 AHSP forms a specific complex with alphaHb and suppresses the heme-catalyzed evolution of reactive oxygen species by converting alphaHb to a conformation in which the heme is coordinated at both axial positions by histidine side chains (bis-histidyl coordination). Histidine 214-223 alpha hemoglobin stabilizing protein Homo sapiens 0-4 19320425-6 2009 Cd(2+) and Msh2-Msh6 interactions involve cysteine sulfhydryl groups, and the high Cd(2+):Msh2-Msh6 ratio implicates other ligands such as histidine, aspartate, glutamate, and the peptide backbone as well. Histidine 139-148 mutS homolog 6 Homo sapiens 95-99 19786583-0 2009 Inhibition of K(Ca)2.2 and K(Ca)2.3 channel currents by protonation of outer pore histidine residues. Histidine 82-91 potassium calcium-activated channel subfamily N member 2 Homo sapiens 14-22 19786583-0 2009 Inhibition of K(Ca)2.2 and K(Ca)2.3 channel currents by protonation of outer pore histidine residues. Histidine 82-91 potassium calcium-activated channel subfamily N member 3 Homo sapiens 27-35 19786583-5 2009 K(Ca)2.2 and K(Ca)2.3 subunits both possess a histidine residue in their outer pore region between the transmembrane S5 segment and the pore helix, with K(Ca)2.3 also exhibiting an additional histidine residue between the selectivity filter and S6. Histidine 46-55 potassium calcium-activated channel subfamily N member 2 Homo sapiens 0-8 19786583-5 2009 K(Ca)2.2 and K(Ca)2.3 subunits both possess a histidine residue in their outer pore region between the transmembrane S5 segment and the pore helix, with K(Ca)2.3 also exhibiting an additional histidine residue between the selectivity filter and S6. Histidine 46-55 potassium calcium-activated channel subfamily N member 3 Homo sapiens 13-21 19786583-5 2009 K(Ca)2.2 and K(Ca)2.3 subunits both possess a histidine residue in their outer pore region between the transmembrane S5 segment and the pore helix, with K(Ca)2.3 also exhibiting an additional histidine residue between the selectivity filter and S6. Histidine 192-201 potassium calcium-activated channel subfamily N member 2 Homo sapiens 0-8 19786583-5 2009 K(Ca)2.2 and K(Ca)2.3 subunits both possess a histidine residue in their outer pore region between the transmembrane S5 segment and the pore helix, with K(Ca)2.3 also exhibiting an additional histidine residue between the selectivity filter and S6. Histidine 192-201 potassium calcium-activated channel subfamily N member 3 Homo sapiens 13-21 19786583-7 2009 The greater sensitivity of K(Ca)2.3 currents to protons arose from the additional histidine residue in the pore, which was more proximal to the conduction pathway and in the electrostatic vicinity of the ion conduction pathway. Histidine 82-91 potassium calcium-activated channel subfamily N member 3 Homo sapiens 27-35 19786583-8 2009 The decrease of channel conductance by extracellular protons was mimicked by mutation of the outer pore histidine in K(Ca)2.2 to an asparagine residue. Histidine 104-113 potassium calcium-activated channel subfamily N member 2 Homo sapiens 117-125 19757839-2 2009 The substitution of the His(4)-Pro(5) dipeptide sequence by the constrained Trp analogue Aia-Gly, in combination with beta(2)hVal substitution at the N-terminus, provided a new stable analogue H-(R)-beta(2)hVal-Tyr-Ile-Aia-Gly-Phe-OH (AL-40) that is a potent ligand for the Ang IV receptor IRAP and selective versus AP-N and the AT1 receptor. Histidine 24-27 interleukin 1 receptor antagonist Homo sapiens 290-294 19767579-5 2009 Mmp-20 cleaves amelogenin sequences after Pro(162), Ser(148), His(62), Ala(63), and Trp(45). Histidine 62-65 amelogenin Sus scrofa 15-25 19399589-5 2009 Further we find that rising [AMP] promotes pSer (only with GTP) but inhibits histidine phosphorylation (pHis) of NDPK from both donors. Histidine 77-86 cytidine/uridine monophosphate kinase 2 Homo sapiens 113-117 19415463-1 2009 The guest editor (AM) provides his perspective on the most recent advances on nucleoside diphosphate kinase (NDPK, otherwise known as AWD or NM23) showcasing phospho-histidine biochemistry and its impact on diverse pathology when disordered. Histidine 166-175 cytidine/uridine monophosphate kinase 2 Homo sapiens 78-107 19415463-1 2009 The guest editor (AM) provides his perspective on the most recent advances on nucleoside diphosphate kinase (NDPK, otherwise known as AWD or NM23) showcasing phospho-histidine biochemistry and its impact on diverse pathology when disordered. Histidine 166-175 cytidine/uridine monophosphate kinase 2 Homo sapiens 109-113 28882106-6 2017 By utilizing plasmid flag-p27kip1, HA-RanBP2, GST-RanBP2 and His-p27kip1 and immunoprecipitation assay, we validated that p27kip1 can serve as the sumoylation target of RanBP2 in QBC939. Histidine 61-64 cyclin dependent kinase inhibitor 1B Homo sapiens 65-72 28500133-7 2017 Furthermore, as measured in a co-immunoprecipitation assay, substitution of the His or Cys heme ligands in Rev-erbbeta was accompanied by a significant loss of NCoR1 binding. Histidine 80-83 nuclear receptor corepressor 1 Homo sapiens 160-165 28302724-6 2017 These results, together with the previous results for the mutants of the His ligands of PD1 and PD2, lead to a definite conclusion that a charge is mainly localized to PD1 in P680<sup/>. Histidine 73-76 PAF1 homolog, Paf1/RNA polymerase II complex component Homo sapiens 96-99 28270603-3 2017 In Arabidopsis thaliana accession Cvi-0, one of the two copies of a duplicated histidine biosynthesis gene, HISN6A, is mutated, making HISN6B essential. Histidine 79-88 histidinol phosphate aminotransferase 1 Arabidopsis thaliana 108-114 26764162-5 2017 The intracellular detection of PPi using PCG also carried out in B16F10 cells where >10 times observed as compared to the PDI-HIS+Cu2+ complex. Histidine 129-132 prolyl 4-hydroxylase, beta polypeptide Mus musculus 125-128 27870532-2 2017 Although its biological function is uncertain, the iron-sulfur cluster in mitoNEET has been proposed to undergo proton-coupled electron transfer involving the histidine ligand to the cluster. Histidine 159-168 CDGSH iron sulfur domain 1 Homo sapiens 74-82 27870532-5 2017 This work suggests that J values or 15 N isotopic frequency shifts may provide methods for determining experimentally whether the histidine ligand to the oxidized iron-sulfur cluster in human mitoNEET and mitoNEET-related proteins is protonated or deprotonated. Histidine 130-139 CDGSH iron sulfur domain 1 Homo sapiens 192-200 27870532-5 2017 This work suggests that J values or 15 N isotopic frequency shifts may provide methods for determining experimentally whether the histidine ligand to the oxidized iron-sulfur cluster in human mitoNEET and mitoNEET-related proteins is protonated or deprotonated. Histidine 130-139 CDGSH iron sulfur domain 1 Homo sapiens 205-213 27640900-3 2017 The current study demonstrated that the amino acids histidine, lysine, threonine inhibited mTOR signaling and IgE-mediated mast cell activation, while the amino acids leucine, isoleucine, valine had no effect on mTOR signaling in BMMCs. Histidine 52-61 mechanistic target of rapamycin kinase Mus musculus 91-95 27406240-1 2017 Arginine 132 (R132) mutations to histidine or cysteine frequently occur to cytosolic NADP+ -isocitrate dehydrogenase (IDH1) in secondary glioblastoma multiforme (GBM) patients, in which GBM develops from a lower grade astroctyoma. Histidine 33-42 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 118-122 27934216-5 2016 Here, we combine various biophysical methods to explore the interaction between this Ctr1 segment and metallochaperone Atox1 and clearly demonstrate that the Ctr1 intracellular loop (1) can coordinate Cu(I) via interactions with the side chains of one histidine and two methionine residues and (2) closely interacts with the Atox1 metallochaperone. Histidine 252-261 solute carrier family 31 member 1 Homo sapiens 85-89 27934216-5 2016 Here, we combine various biophysical methods to explore the interaction between this Ctr1 segment and metallochaperone Atox1 and clearly demonstrate that the Ctr1 intracellular loop (1) can coordinate Cu(I) via interactions with the side chains of one histidine and two methionine residues and (2) closely interacts with the Atox1 metallochaperone. Histidine 252-261 solute carrier family 31 member 1 Homo sapiens 158-162 27792302-5 2016 Each STEAP1 protomer binds one heme prosthetic group that is mainly low-spin with a pair of histidine axial ligands, with small portions of high-spin and P450-type heme. Histidine 92-101 STEAP family member 1 Homo sapiens 5-11 19396588-2 2009 In order to bind the enzyme complex consisting of UL5 and UL52 gene functions to the affinity column, the C-terminus of the UL5 gene of HSV-1 strain ANG was fused in-frame with a sequence encoding six histidines, resulting in a His6-tagged DNA helicase (UL5his) when expressed via recombinant baculovirus. Histidine 201-211 helicase-primase primase subunit Human alphaherpesvirus 1 58-62 19346561-2 2009 Like other alpha-oxamine synthase subfamily enzymes, SPT is different from most of the fold type I enzymes in that its re face of the PLP-Lys aldimine is occupied by a His residue (His(159)) instead of an aromatic amino acid residue. Histidine 168-171 alanine--glyoxylate and serine--pyruvate aminotransferase Homo sapiens 53-56 19346561-2 2009 Like other alpha-oxamine synthase subfamily enzymes, SPT is different from most of the fold type I enzymes in that its re face of the PLP-Lys aldimine is occupied by a His residue (His(159)) instead of an aromatic amino acid residue. Histidine 181-184 alanine--glyoxylate and serine--pyruvate aminotransferase Homo sapiens 53-56 19502167-2 2009 In this study, we investigated the influence of DNA methyltransferase 3b (DNMT3b) on fragile histidine trial (FHIT) expression and on DNA methylation of the FHIT promoter region in the hepatoma cell line SMMC-7721. Histidine 93-102 DNA methyltransferase 3 beta Homo sapiens 48-72 19502167-2 2009 In this study, we investigated the influence of DNA methyltransferase 3b (DNMT3b) on fragile histidine trial (FHIT) expression and on DNA methylation of the FHIT promoter region in the hepatoma cell line SMMC-7721. Histidine 93-102 DNA methyltransferase 3 beta Homo sapiens 74-80 20416773-0 2009 Myosin is solubilized in a neutral and low ionic strength solution containing l-histidine. Histidine 78-89 myosin heavy chain 14 Homo sapiens 0-6 20416773-2 2009 In this study, the behavior and morphology of myosin solubilized in a low ionic strength solution containing l-histidine (l-His) was investigated. Histidine 109-120 myosin heavy chain 14 Homo sapiens 46-52 20416773-2 2009 In this study, the behavior and morphology of myosin solubilized in a low ionic strength solution containing l-histidine (l-His) was investigated. Histidine 122-127 myosin heavy chain 14 Homo sapiens 46-52 20416773-3 2009 More than 80% of myosin was solubilized in a low ionic strength solution with dialysis against a solution containing 1mM KCl and 5mM l-His. Histidine 133-138 myosin heavy chain 14 Homo sapiens 17-23 20416773-4 2009 Transmission electron microscopy with rotary shadowing demonstrated that the rod of myosin in a low ionic strength solution containing l-His is longer than that of myosin in a high ionic strength solution. Histidine 135-140 myosin heavy chain 14 Homo sapiens 84-90 20416773-5 2009 The elongation of the myosin rod in a low ionic strength solution containing l-His would inhibit the formation of a filament, resulting in the solubilization of myosin. Histidine 77-82 myosin heavy chain 14 Homo sapiens 22-28 20416773-5 2009 The elongation of the myosin rod in a low ionic strength solution containing l-His would inhibit the formation of a filament, resulting in the solubilization of myosin. Histidine 77-82 myosin heavy chain 14 Homo sapiens 161-167 19318355-3 2009 In the present study, we mapped the region of mouse ANGPTL4 recognized by mAb 14D12 to amino acids Gln(29)-His(53), which we designate as specific epitope 1 (SE1). Histidine 107-110 angiopoietin-like 4 Mus musculus 52-59 19318355-3 2009 In the present study, we mapped the region of mouse ANGPTL4 recognized by mAb 14D12 to amino acids Gln(29)-His(53), which we designate as specific epitope 1 (SE1). Histidine 107-110 granzyme A Mus musculus 138-161 19318355-5 2009 Alignment of all angiopoietin family members revealed that a sequence similar to ANGPTL4 SE1 was present only in ANGPTL3, corresponding to amino acids Glu(32)-His(55). Histidine 159-162 angiopoietin-like 4 Mus musculus 81-88 19318355-5 2009 Alignment of all angiopoietin family members revealed that a sequence similar to ANGPTL4 SE1 was present only in ANGPTL3, corresponding to amino acids Glu(32)-His(55). Histidine 159-162 granzyme A Mus musculus 89-92 19442270-4 2009 Herein we validate the use in vitro of recombinant 6 x His-tagged-PAI-2 lacking the intrahelical loop between C and D alpha-helices (PAI-2 Delta CD-loop) for these purposes. Histidine 55-58 serpin family B member 2 Homo sapiens 66-71 19442270-4 2009 Herein we validate the use in vitro of recombinant 6 x His-tagged-PAI-2 lacking the intrahelical loop between C and D alpha-helices (PAI-2 Delta CD-loop) for these purposes. Histidine 55-58 serpin family B member 2 Homo sapiens 133-138 19413965-3 2009 We reasoned that histidine 562 in hERG1 could play an important structure-function role. Histidine 17-26 potassium voltage-gated channel subfamily H member 2 Homo sapiens 34-39 27933794-1 2016 Histone deacetylase 8 (HDAC8) catalyzes the hydrolysis of acetyl-l-lysine to yield products l-lysine and acetate through a mechanism in which a nucleophilic water molecule is activated by a histidine general base and a catalytic metal ion (Zn2+ or Fe2+). Histidine 190-199 histone deacetylase 8 Homo sapiens 0-21 27933794-1 2016 Histone deacetylase 8 (HDAC8) catalyzes the hydrolysis of acetyl-l-lysine to yield products l-lysine and acetate through a mechanism in which a nucleophilic water molecule is activated by a histidine general base and a catalytic metal ion (Zn2+ or Fe2+). Histidine 190-199 histone deacetylase 8 Homo sapiens 23-28 27522067-9 2016 Conversely, two substitutions (distal-Thr to Ser and distal-His to Tyr) were sufficient to bestow IDO1-like high affinity on ancestral and chicken IDO2. Histidine 60-63 indoleamine 2,3-dioxygenase 1 Homo sapiens 98-102 27522067-9 2016 Conversely, two substitutions (distal-Thr to Ser and distal-His to Tyr) were sufficient to bestow IDO1-like high affinity on ancestral and chicken IDO2. Histidine 60-63 indoleamine 2,3-dioxygenase 2 Homo sapiens 147-151 27588329-9 2016 The complex structure of cyt c meant that this reactant was represented solely by the heme group including the chiral axial ligands L-His and L-Met. Histidine 132-137 cytochrome c, somatic Equus caballus 25-30 27346274-11 2016 Additional mutants in EC1/TM3 explored the molecular basis for these changes demonstrated in EC1, particularly important is the presence of aromatic-interactions by His(107), rather than hydrogen-bonding or charge-charge interactions, for determining Bantag-1 high affinity/selectivity. Histidine 165-168 Susceptibility to lysis by alloreactive natural killer cells Homo sapiens 22-25 27346274-11 2016 Additional mutants in EC1/TM3 explored the molecular basis for these changes demonstrated in EC1, particularly important is the presence of aromatic-interactions by His(107), rather than hydrogen-bonding or charge-charge interactions, for determining Bantag-1 high affinity/selectivity. Histidine 165-168 Susceptibility to lysis by alloreactive natural killer cells Homo sapiens 93-96 27416303-7 2016 A mutant form of PAI-1 lacking two N-terminal histidine residues at positions 2 and 3 exhibits similar increases in dynamics upon Cu(II) binding compared to that of active wild-type PAI-1, indicating that the observed structural effects are not a result of coordination of Cu(II) to these histidine residues. Histidine 289-298 serpin family E member 1 Homo sapiens 17-22 27399771-5 2016 The primary structure of N. nomurai CTRL-1 includes a leader peptide and a highly conserved catalytic triad of His(69), Asp(117), and Ser(216). Histidine 111-114 chymotrypsin like Homo sapiens 36-40 27560991-9 2016 Among the amino acids tested (all in L configuration), arginine, lysine, tryptophan and histidine enhanced residual activity of rCA1 and rCA4. Histidine 88-97 carbonic anhydrase 1 Rattus norvegicus 128-132 27834323-1 2016 BACKGROUND & OBJECTIVES: CNDP1 gene, present on chromosome 18q22.3-23, encodes carnosinase, the rate-limiting enzyme in hydrolysis of carnosine to ss-alanine and L-histidine. Histidine 166-177 carnosine dipeptidase 1 Homo sapiens 29-34 25693639-3 2016 The protonation of histidines in the sequence of [D]-H6L9 under pH 6.3 could switch the surface charge of D-Lip from negative (under pH 7.4) to positive (under pH 6.3), and the cellular uptake and tumor spheroids uptake were increased accordingly. Histidine 19-29 CCAAT/enhancer binding protein (C/EBP), beta Mus musculus 108-111 27018888-3 2016 Here, we use activity-based profiling to discover that the poorly characterized multipass transmembrane proteins AIG1 and ADTRP are atypical hydrolytic enzymes that depend on conserved threonine and histidine residues for catalysis. Histidine 199-208 androgen induced 1 Homo sapiens 113-117 27018888-3 2016 Here, we use activity-based profiling to discover that the poorly characterized multipass transmembrane proteins AIG1 and ADTRP are atypical hydrolytic enzymes that depend on conserved threonine and histidine residues for catalysis. Histidine 199-208 androgen dependent TFPI regulating protein Homo sapiens 122-127 26773745-4 2016 In this study we used an optimized codon sequence to overexpress histidine-tagged human KAT2 (hKAT2) using an Escherichia coli expression system. Histidine 65-74 aminoadipate aminotransferase Homo sapiens 88-92 26773745-4 2016 In this study we used an optimized codon sequence to overexpress histidine-tagged human KAT2 (hKAT2) using an Escherichia coli expression system. Histidine 65-74 aminoadipate aminotransferase Homo sapiens 94-99 26792558-4 2016 The functionality and validity of the nickel magnetic nanoparticles were attested by purification of three different bioactive His-tagged recombinant fusion proteins including hIGF-1, GM-CSF and bFGF. Histidine 127-130 colony stimulating factor 2 Homo sapiens 184-190 27010847-3 2016 Analysis of the crystal CGL structures bound to galactose, galactosamine, and globotriose Gb3 indicated that each CGL can bind three ligands through a carbohydrate-binding motif involving an extensive histidine- and water-mediated hydrogen bond network. Histidine 201-210 alpha 1,4-galactosyltransferase (P blood group) Homo sapiens 90-93 19246456-5 2009 Substitution of the three polar amino acid residues (His(46), Gln(50), and Gln(53)) within this motif with alanine abolishes the inhibitory effect of Angptl4 on LPL in vitro and also abrogates the ability of Angptl4 to elevate plasma triglyceride levels in mice. Histidine 53-56 angiopoietin-like 4 Mus musculus 150-157 19211747-5 2009 Histidine 66 is located within the gp41-interactive inner domain of gp120 and, in other studies, has been shown to decrease the sampling of the CD4-bound conformation by unliganded gp120. Histidine 0-9 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 68-73 19211747-5 2009 Histidine 66 is located within the gp41-interactive inner domain of gp120 and, in other studies, has been shown to decrease the sampling of the CD4-bound conformation by unliganded gp120. Histidine 0-9 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 181-186 26867578-9 2016 A comparison with the PIG-L deacetylases led to a proposed mechanism for GalB wherein Glu-48 positions and activates the metal-ligated water for the hydration reaction and His-164 acts as a catalytic acid. Histidine 172-175 phosphatidylinositol glycan anchor biosynthesis class L Sus scrofa 22-27 26984496-5 2016 A recombinant histidine-tagged sPRR (sPRR-His) in the nanomolar range induced a remarkable increase in the abundance of renal aquaporin 2 (AQP2) protein in primary rat inner medullary collecting duct cells. Histidine 14-23 small proline-rich protein 1A Rattus norvegicus 31-35 19344784-5 2009 Pretreatment of host cells with P21-His(6) inhibited cell invasion by extracellular amastigotes from G and CL strains. Histidine 36-39 H3 histone pseudogene 16 Homo sapiens 32-35 19146426-8 2009 This His/Arg-18 mutation results in reduced affinity binding of human IAPP to insulin in comparison to rat IAPP as it is detected by surface plasmon resonance biosensor analysis. Histidine 5-8 islet amyloid polypeptide Rattus norvegicus 107-111 19382167-3 2009 The C-terminus of Vif contains a conserved His-X(5)-Cys-X(17-18)-Cys-X(3-5)-His (HCCH) motif that binds zinc and interacts with Cul5. Histidine 43-46 cullin 5 Homo sapiens 128-132 19382167-3 2009 The C-terminus of Vif contains a conserved His-X(5)-Cys-X(17-18)-Cys-X(3-5)-His (HCCH) motif that binds zinc and interacts with Cul5. Histidine 76-79 cullin 5 Homo sapiens 128-132 19323056-15 2009 The BMP-1/HIS was present at higher level in control tissue, during II phase of the menstrual cycle and in postmenopausal state, whereas in the tumour tissue its lowest level was at II phase of the cycle. Histidine 10-13 bone morphogenetic protein 1 Homo sapiens 4-9 18354387-7 2009 With a non-synonymous G to A transition, rs2734849 produces an amino-acid change (arginine to histidine) in C-terminal ankyrin repeat domain of ANKK1. Histidine 94-103 ankyrin repeat and kinase domain containing 1 Homo sapiens 144-149 19238200-5 2009 METHODS AND FINDINGS: An ELISA assay was developed for measuring hepcidin serum concentration using a recombinant hepcidin25-His peptide and a polyclonal antibody against this peptide, which was able to identify native hepcidin. Histidine 125-128 hepcidin antimicrobial peptide Homo sapiens 65-73 18952607-5 2008 A direct interaction was indicated by in vitro pull-down assay, in which S-His-RASA3 preferentially bound guanosine 5"-O-(gamma-thio)triphosphate-activated Galphai3 and Galphai2 compared with guanosine 5"-O-(beta-thio)diphosphate-inactivated proteins. Histidine 75-78 G protein subunit alpha i2 Rattus norvegicus 169-177 26984496-5 2016 A recombinant histidine-tagged sPRR (sPRR-His) in the nanomolar range induced a remarkable increase in the abundance of renal aquaporin 2 (AQP2) protein in primary rat inner medullary collecting duct cells. Histidine 14-23 small proline-rich protein 1A Rattus norvegicus 37-41 26984496-5 2016 A recombinant histidine-tagged sPRR (sPRR-His) in the nanomolar range induced a remarkable increase in the abundance of renal aquaporin 2 (AQP2) protein in primary rat inner medullary collecting duct cells. Histidine 14-23 aquaporin 2 Rattus norvegicus 126-137 26984496-5 2016 A recombinant histidine-tagged sPRR (sPRR-His) in the nanomolar range induced a remarkable increase in the abundance of renal aquaporin 2 (AQP2) protein in primary rat inner medullary collecting duct cells. Histidine 14-23 aquaporin 2 Rattus norvegicus 139-143 26984496-5 2016 A recombinant histidine-tagged sPRR (sPRR-His) in the nanomolar range induced a remarkable increase in the abundance of renal aquaporin 2 (AQP2) protein in primary rat inner medullary collecting duct cells. Histidine 42-45 small proline-rich protein 1A Rattus norvegicus 31-35 26984496-5 2016 A recombinant histidine-tagged sPRR (sPRR-His) in the nanomolar range induced a remarkable increase in the abundance of renal aquaporin 2 (AQP2) protein in primary rat inner medullary collecting duct cells. Histidine 42-45 small proline-rich protein 1A Rattus norvegicus 37-41 26984496-5 2016 A recombinant histidine-tagged sPRR (sPRR-His) in the nanomolar range induced a remarkable increase in the abundance of renal aquaporin 2 (AQP2) protein in primary rat inner medullary collecting duct cells. Histidine 42-45 aquaporin 2 Rattus norvegicus 126-137 26984496-5 2016 A recombinant histidine-tagged sPRR (sPRR-His) in the nanomolar range induced a remarkable increase in the abundance of renal aquaporin 2 (AQP2) protein in primary rat inner medullary collecting duct cells. Histidine 42-45 aquaporin 2 Rattus norvegicus 139-143 26707622-11 2016 Immunoblotting indicated that maltose-binding protein (MBP)-OGT inhibited the binding of His-p120 to GST-ECD in a dose-dependent manner. Histidine 89-92 O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens 60-63 26900445-3 2016 Mutagenesis of the "distal" histidine residue was particularly effective in enhancing the azide oxidation reactivity of myoglobin, enabling these reactions to proceed in good to excellent yields (37-89%) and to be carried out at a synthetically useful scale. Histidine 28-37 myoglobin Homo sapiens 120-129 27132720-6 2016 Molecular docking study reveals the selectivity of these molecules towards ALDH1A1 (PDB: 4WP7) and important binding residues (GLY 125, 458; THR 129; TRP 178; TYR 297; PHE 171, 466; VAL 174, 460; MET 175; HIS 293 etc.) Histidine 205-208 aldehyde dehydrogenase 1 family member A1 Homo sapiens 75-82 18823950-8 2008 Quenching of PCNA photo-crosslinking by histidine, and enhancement by deuterium oxide, suggest a role for singlet oxygen in the crosslinking. Histidine 40-49 proliferating cell nuclear antigen Homo sapiens 13-17 18835256-7 2008 Thus, the His residues of hRAMP2 and -3 differentially govern AM receptor function. Histidine 10-13 receptor activity modifying protein 2 Homo sapiens 26-39 18725328-5 2008 In addition, polymerization appears to depend on formation of the phosphoryl-Histidine intermediate of the enzyme, suggesting a previously unappreciated conformational change in NDPK during its catalytic cycle. Histidine 77-86 cytidine/uridine monophosphate kinase 2 Homo sapiens 178-182 19568996-8 2008 The mutation was present in a critical region of the COX1 gene, the V374M change being close to the two histidine residues His376 and His378 co-ordinating with the heme a and a (3), and His367 which co-ordinates a magnesium ion. Histidine 104-113 mitochondrially encoded cytochrome c oxidase I Homo sapiens 53-57 18844346-8 2008 The ligand binding analyses for the ferric and ferrous myoglobin suggest that the proximal histidine pulls the iron atom from the deformed core to reduce the interaction between the iron and exogenous ligands. Histidine 91-100 myoglobin Homo sapiens 55-64 26606908-1 2015 Myoglobin (Mb) undergoes pronounced heme loss under denaturing conditions wherein the proximal histidine gets protonated. Histidine 95-104 myoglobin Homo sapiens 0-9 26596869-7 2015 By conducting pepsin digestion, amino-acid specific chemical modifications, peptide mapping, and measuring the effects of elution residence time, a histidine in the variable fragment (Fab) was identified to be the root cause. Histidine 148-157 FA complementation group B Homo sapiens 184-187 18847225-1 2008 The release of ligand from the low-density lipoprotein receptor (LDLR) has been postulated to involve a "histidine switch"-induced intramolecular rearrangement that discharges bound ligand. Histidine 105-114 low density lipoprotein receptor Homo sapiens 31-63 18847225-1 2008 The release of ligand from the low-density lipoprotein receptor (LDLR) has been postulated to involve a "histidine switch"-induced intramolecular rearrangement that discharges bound ligand. Histidine 105-114 low density lipoprotein receptor Homo sapiens 65-69 26235215-0 2015 The reaction of a platinated methionine motif of CTR1 with cysteine and histidine is dependent upon the type of precursor platinum complex. Histidine 72-81 solute carrier family 31 member 1 Homo sapiens 49-53 26104663-8 2015 Sequence analysis showed the mutation in LDD731 caused a histidine-to-tyrosine substitution of the amino acid codon 382 within the RING finger domain of c-Cbl. Histidine 57-66 Cbl proto-oncogene Homo sapiens 153-158 26402434-4 2015 Rat GLUT4 containing FLAG and His tags at the amino and carboxy termini, respectively, was engineered and stably transfected into HEK-293 cells. Histidine 30-33 solute carrier family 2 member 4 Rattus norvegicus 4-9 26668776-1 2015 L-type amino acid transporter 1 (LAT1) is an L-type amino acid transporter and transports large neutral amino acids such as leucine, isoleucine, valine, phenylalanine, tyrosine, tryptophan, methionine, and histidine. Histidine 206-215 solute carrier family 7 member 5 Homo sapiens 0-31 19140321-4 2008 We first obtained antiserum to recombinant His-Xvent-2 and showed that the transcription factor Xvent-2 was present in eggs and embryos of Xenopus laevis from the cleavage up to the beginning of spontaneous motions (stage 26). Histidine 43-46 VENT homeobox 2, gene 2 L homeolog Xenopus laevis 47-54 19140321-4 2008 We first obtained antiserum to recombinant His-Xvent-2 and showed that the transcription factor Xvent-2 was present in eggs and embryos of Xenopus laevis from the cleavage up to the beginning of spontaneous motions (stage 26). Histidine 43-46 VENT homeobox 2, gene 2 L homeolog Xenopus laevis 96-103 18811882-3 2008 Based chi on the polymorphisms of EPHX1 gene (tyrosine/histidine 113, histidine/arginine 139), the population can be classified into four groups of putative EPHX1 phenotypes (fast, normal, slow and very slow). Histidine 55-64 epoxide hydrolase 1 Homo sapiens 34-39 18811882-3 2008 Based chi on the polymorphisms of EPHX1 gene (tyrosine/histidine 113, histidine/arginine 139), the population can be classified into four groups of putative EPHX1 phenotypes (fast, normal, slow and very slow). Histidine 70-79 epoxide hydrolase 1 Homo sapiens 34-39 18703510-5 2008 We successfully pulled down histidine-tagged hsp90alpha- and PA28alpha-induced, newly assembled 26 S proteasomes from the cell extracts for in vitro epitope production assay, and we found these structures to be sensitive to geldanamycin, an hsp90 inhibitor. Histidine 28-37 heat shock protein 90 alpha family class A member 1 Homo sapiens 45-55 18703510-5 2008 We successfully pulled down histidine-tagged hsp90alpha- and PA28alpha-induced, newly assembled 26 S proteasomes from the cell extracts for in vitro epitope production assay, and we found these structures to be sensitive to geldanamycin, an hsp90 inhibitor. Histidine 28-37 heat shock protein 90 alpha family class A member 1 Homo sapiens 45-50 18728031-10 2008 However, unlike thrombopoietin, butyzamide did not react with murine Mpl and was shown to require the histidine residue in the transmembrane domain of Mpl for its agonistic activity. Histidine 102-111 myeloproliferative leukemia virus oncogene Mus musculus 151-154 18765564-1 2008 The intracellular target of diphtheria toxin is a modified histidine residue, diphthamide, in the translation elongation factor, eEF2 (also known as EFT1). Histidine 59-68 eukaryotic translation elongation factor 2 Mus musculus 129-133 26668776-1 2015 L-type amino acid transporter 1 (LAT1) is an L-type amino acid transporter and transports large neutral amino acids such as leucine, isoleucine, valine, phenylalanine, tyrosine, tryptophan, methionine, and histidine. Histidine 206-215 solute carrier family 7 member 5 Homo sapiens 33-37 26324451-4 2015 Thi5p synthesizes HMP-P from histidine and pyridoxal-5-phosphate and was reported to use a backbone histidine as the substrate, which would mean that it was a single-turnover enzyme. Histidine 29-38 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase Saccharomyces cerevisiae S288C 0-5 18647362-4 2008 In HLA-B*4455, an nt exchange occurred in codon 9 of HLA-B*44020101, resulting in a change of the amino acid coding from tyrosine to histidine. Histidine 133-142 major histocompatibility complex, class I, B Homo sapiens 3-8 18647362-4 2008 In HLA-B*4455, an nt exchange occurred in codon 9 of HLA-B*44020101, resulting in a change of the amino acid coding from tyrosine to histidine. Histidine 133-142 major histocompatibility complex, class I, B Homo sapiens 53-58 18480028-3 2008 Because ACAT enzymes have an intrinsic thioesterase activity, we hypothesized that by analogy with the thioesterase domain of fatty acid synthase, the active site of ACAT enzymes may comprise a catalytic triad of ser-his-asp (S-H-D) amino acid residues. Histidine 217-220 acetyl-CoA acetyltransferase 1 Homo sapiens 8-12 18480028-3 2008 Because ACAT enzymes have an intrinsic thioesterase activity, we hypothesized that by analogy with the thioesterase domain of fatty acid synthase, the active site of ACAT enzymes may comprise a catalytic triad of ser-his-asp (S-H-D) amino acid residues. Histidine 217-220 acetyl-CoA acetyltransferase 1 Homo sapiens 166-170 18797515-7 2008 Both antifungal and membrane-rupturing activities of HRG were enhanced at low pH, and mapped to the histidine-rich region of the protein. Histidine 100-109 histidine-rich glycoprotein Mus musculus 53-56 18373493-0 2008 The role of the diphthamide-containing loop within eukaryotic elongation factor 2 in ADP-ribosylation by Pseudomonas aeruginosa exotoxin A. eEF2 (eukaryotic elongation factor 2) contains a post-translationally modified histidine residue, known as diphthamide, which is the specific ADP-ribosylation target of diphtheria toxin, cholix toxin and Pseudomonas aeruginosa exotoxin A. Site-directed mutagenesis was conducted on residues within the diphthamide-containing loop (Leu693-Gly703) of eEF2 by replacement with alanine. Histidine 219-228 elongation factor 2 Saccharomyces cerevisiae S288C 62-81 18373493-0 2008 The role of the diphthamide-containing loop within eukaryotic elongation factor 2 in ADP-ribosylation by Pseudomonas aeruginosa exotoxin A. eEF2 (eukaryotic elongation factor 2) contains a post-translationally modified histidine residue, known as diphthamide, which is the specific ADP-ribosylation target of diphtheria toxin, cholix toxin and Pseudomonas aeruginosa exotoxin A. Site-directed mutagenesis was conducted on residues within the diphthamide-containing loop (Leu693-Gly703) of eEF2 by replacement with alanine. Histidine 219-228 elongation factor 2 Saccharomyces cerevisiae S288C 157-176 18640599-1 2008 A genetically engineered porcine myoglobin triple mutant (H64V/V68H/H93A) (VHA-Mb) contains 6 non-axial His residues (His24, His36, His48, His81, His82, and His119) besides two candidate axial His residues (His68 and His97). Histidine 104-107 myoglobin Homo sapiens 33-42 26324451-4 2015 Thi5p synthesizes HMP-P from histidine and pyridoxal-5-phosphate and was reported to use a backbone histidine as the substrate, which would mean that it was a single-turnover enzyme. Histidine 100-109 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase Saccharomyces cerevisiae S288C 0-5 26205368-3 2015 The major differences between CTR1 and CTR2 are that CTR1 contains a HIS/MET-rich domain N-terminal of the METS that participate in the first two stacked rings that form the pore, and a longer C-terminal tail that includes a Cu binding HIS-CYS-HIS (HCH) motif right at the end. Histidine 69-72 solute carrier family 31 member 1 Homo sapiens 30-34 26205368-3 2015 The major differences between CTR1 and CTR2 are that CTR1 contains a HIS/MET-rich domain N-terminal of the METS that participate in the first two stacked rings that form the pore, and a longer C-terminal tail that includes a Cu binding HIS-CYS-HIS (HCH) motif right at the end. Histidine 69-72 solute carrier family 31 member 2 Homo sapiens 39-43 26205368-3 2015 The major differences between CTR1 and CTR2 are that CTR1 contains a HIS/MET-rich domain N-terminal of the METS that participate in the first two stacked rings that form the pore, and a longer C-terminal tail that includes a Cu binding HIS-CYS-HIS (HCH) motif right at the end. Histidine 69-72 solute carrier family 31 member 1 Homo sapiens 53-57 26205368-3 2015 The major differences between CTR1 and CTR2 are that CTR1 contains a HIS/MET-rich domain N-terminal of the METS that participate in the first two stacked rings that form the pore, and a longer C-terminal tail that includes a Cu binding HIS-CYS-HIS (HCH) motif right at the end. Histidine 236-239 solute carrier family 31 member 1 Homo sapiens 53-57 26120805-1 2015 By employing DNAzyme as a recognition group and amplifier, and DNA-stabilized silver nanoclusters (DNA/AgNCs) as signal reporters, we reported for the first time a label-free catalytic and molecular beacon as an amplified biosensing platform for highly selective detection of cofactors such as Pb(2+) and L-histidine. Histidine 305-316 ubiquitin like 5 Homo sapiens 199-205 26172912-0 2015 Distal Histidine Modulates the Unusual O-Binding of Nitrite to Myoglobin: Evidence from the Quantum Chemical Analysis of EPR Parameters. Histidine 7-16 myoglobin Homo sapiens 63-72 25808120-11 2015 The Trp-His peptide was not visualized in the presence of Gly-Sar, which is a model peptide that is transported via the intestinal proton-coupled peptide transporter 1 (PepT1) transporter. Histidine 8-11 solute carrier family 15 member 1 Rattus norvegicus 169-174 26213944-3 2015 A peptide receptor (His-Pro-Asn-Phe-Ser-Lys-Tyr-Ile-Leu-His-Gln-Arg) that has high binding affinity for 2,4-DNT was immobilized on the surface of the cantilever sensors to detect 2,4-DNT vapor for highly selective detection. Histidine 20-23 5', 3'-nucleotidase, cytosolic Homo sapiens 108-111 26213944-3 2015 A peptide receptor (His-Pro-Asn-Phe-Ser-Lys-Tyr-Ile-Leu-His-Gln-Arg) that has high binding affinity for 2,4-DNT was immobilized on the surface of the cantilever sensors to detect 2,4-DNT vapor for highly selective detection. Histidine 20-23 5', 3'-nucleotidase, cytosolic Homo sapiens 183-186 26213944-3 2015 A peptide receptor (His-Pro-Asn-Phe-Ser-Lys-Tyr-Ile-Leu-His-Gln-Arg) that has high binding affinity for 2,4-DNT was immobilized on the surface of the cantilever sensors to detect 2,4-DNT vapor for highly selective detection. Histidine 56-59 5', 3'-nucleotidase, cytosolic Homo sapiens 108-111 26001783-11 2015 Carnosine and Gly-His were the best substrates for all UPF0586 orthologs studied, although the enzymes also methylated other l-histidine-containing di- and tripeptides. Histidine 125-136 carnosine N-methyltransferase 1 Homo sapiens 55-62 18577015-8 2008 The nutritional properties of sample showed that enrichment of semolina with MPI had a pronounced effect on lysine, cysteine, arginine, and histidine contents. Histidine 140-149 mannose phosphate isomerase Homo sapiens 77-80 26013822-5 2015 The acid-induced dissociation of RAP is mediated by its D3 domain, a relatively unstable three-helical bundle that denatures at pH <6.2 due to protonation of key histidine residues on helices 2 and 3. Histidine 165-174 LDL receptor related protein associated protein 1 Homo sapiens 33-36 26013822-7 2015 By combining this disulfide bond with elimination of key histidine residues, we generated a stable RAP molecule that is resistant to both pH- and heat-induced denaturation. Histidine 57-66 LDL receptor related protein associated protein 1 Homo sapiens 99-102 26132828-11 2015 Catalysis is based on a cysteine-histidine-asparagine triad, which is shared with human PAD1-PAD4 and other guanidino-group modifying enzymes. Histidine 33-42 peptidyl arginine deiminase 1 Homo sapiens 88-92 26132828-11 2015 Catalysis is based on a cysteine-histidine-asparagine triad, which is shared with human PAD1-PAD4 and other guanidino-group modifying enzymes. Histidine 33-42 peptidyl arginine deiminase 4 Homo sapiens 93-97 25960268-5 2015 Moreover, the H174R mutation of the HxD-histidine, in the tumor suppressor LKB1 abrogates the inhibition of anchorage-independent growth of A549 cells by WT LKB1. Histidine 40-49 serine/threonine kinase 11 Homo sapiens 75-79 25960268-5 2015 Moreover, the H174R mutation of the HxD-histidine, in the tumor suppressor LKB1 abrogates the inhibition of anchorage-independent growth of A549 cells by WT LKB1. Histidine 40-49 serine/threonine kinase 11 Homo sapiens 157-161 25881887-8 2015 Further analyses of affinity-purified His-tag LAPTM4B overexpressed in HEK cells showed that the 31.5 kDa protein represented the ubiquinated isoform of the 26.3 kDa native protein. Histidine 38-41 lysosomal-associated transmembrane protein 4B Bos taurus 46-53 18263814-1 2008 PURPOSE: A Tyr-to-His (Y402H) sequence variant in the factor H (FH) and factor H-like protein (FHL-1) gene is strongly associated with an increased susceptibility for age-related macular degeneration (AMD). Histidine 18-21 four and a half LIM domains 1 Homo sapiens 95-100 25306337-5 2015 These results demonstrate that the introduction of L-lys and L-his causes the unfolding of myosin, resulting in loss of alpha-helical structure, which is followed by increases in random coils, beta-turns and beta-sheets, which exposes buried hydrophobic and sulphydryl groups to the myosin surface, ultimately increasing the solubility of porcine myosin. Histidine 61-66 myosin heavy chain 14 Homo sapiens 91-97 25306337-5 2015 These results demonstrate that the introduction of L-lys and L-his causes the unfolding of myosin, resulting in loss of alpha-helical structure, which is followed by increases in random coils, beta-turns and beta-sheets, which exposes buried hydrophobic and sulphydryl groups to the myosin surface, ultimately increasing the solubility of porcine myosin. Histidine 61-66 myosin heavy chain 14 Homo sapiens 283-289 25306337-5 2015 These results demonstrate that the introduction of L-lys and L-his causes the unfolding of myosin, resulting in loss of alpha-helical structure, which is followed by increases in random coils, beta-turns and beta-sheets, which exposes buried hydrophobic and sulphydryl groups to the myosin surface, ultimately increasing the solubility of porcine myosin. Histidine 61-66 myosin heavy chain 14 Homo sapiens 283-289 25516571-0 2015 Characterization of the histidine-rich loop of Arabidopsis vacuolar membrane zinc transporter AtMTP1 as a sensor of zinc level in the cytosol. Histidine 24-33 zinc transporter Arabidopsis thaliana 94-100 18230330-0 2008 Mutational analysis of histidine residues in the human proton-coupled amino acid transporter PAT1. Histidine 23-32 solute carrier family 36 member 1 Homo sapiens 93-97 18230330-4 2008 Three histidine residues are conserved among the H+-coupled amino acid transporters PAT1 to 4 from different animal species. Histidine 6-15 solute carrier family 36 member 1 Homo sapiens 84-88 18230330-6 2008 His-55 was found to be essential for the catalytic activity of hPAT1 because the corresponding mutants H55A, H55N and H55E had no detectable l-proline transport activity. Histidine 0-3 solute carrier family 36 member 1 Homo sapiens 63-68 18230330-9 2008 We conclude that His-55 might be responsible for binding and translocation of H+ in the course of cellular amino acid uptake by PAT1. Histidine 17-20 solute carrier family 36 member 1 Homo sapiens 128-132 18261921-5 2008 Metal affinity purification yielded up to 18 microg of histidine-tagged annexin A5 fusions per ml processed cell culture supernatants. Histidine 55-64 annexin A5 Homo sapiens 72-82 18177055-5 2008 First, variants of RAP-D3 resistant to low pH-induced unfolding were constructed by replacing interior histidine residues with phenylalanines. Histidine 103-112 LDL receptor related protein associated protein 1 Homo sapiens 19-25 18478981-9 2008 Assays of serially diluted His-Trx-VEGF1-100 by the established sandwich ELISA method showed that the linear range of the standard curve was 0.625-320 ng/mL, with the squared correlation coefficient R2 = 0.991. Histidine 27-30 thioredoxin Homo sapiens 31-34 17997327-2 2008 We have used a pET-ubiquitin expression system to produce respiratory syncytial virus (RSV) NS1 protein in E. coli that contains a hexahistidine-tag on either the amino- or carboxyl-terminus (His(6)-NS1 and NS1-His(6), respectively). Histidine 192-195 non-structural protein 1 (1C) Respiratory syncytial virus 92-95 17997327-2 2008 We have used a pET-ubiquitin expression system to produce respiratory syncytial virus (RSV) NS1 protein in E. coli that contains a hexahistidine-tag on either the amino- or carboxyl-terminus (His(6)-NS1 and NS1-His(6), respectively). Histidine 211-214 non-structural protein 1 (1C) Respiratory syncytial virus 92-95 18163536-9 2008 In vivo, the non-His-tagged variant 111 In-[MMA-DOTA-Cys61]-Z HER2:2395-Cys demonstrated appreciably lower liver uptake than its His-tag-containing counterpart. Histidine 17-20 erb-b2 receptor tyrosine kinase 2 Mus musculus 62-66 18163536-9 2008 In vivo, the non-His-tagged variant 111 In-[MMA-DOTA-Cys61]-Z HER2:2395-Cys demonstrated appreciably lower liver uptake than its His-tag-containing counterpart. Histidine 129-132 erb-b2 receptor tyrosine kinase 2 Mus musculus 62-66 17936057-6 2008 Interestingly, the interaction of both isoforms with Shp2 in vivo was found using stable cell lines expressing eEF1A1-His or eEF1A2-His. Histidine 132-135 eukaryotic translation elongation factor 1 alpha 2 Homo sapiens 125-131 17956868-8 2007 Replacing Pro-40 of UGT1A4 by histidine expanded the glucuronidation activity of the enzyme to phenolic and carboxylic compounds, therefore, leading to UGT1A3-type isoform in terms of substrate specificity. Histidine 30-39 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 20-26 17956868-9 2007 Conversely, when His-40 residue of UGT1A3 was replaced with proline, the substrate specificity shifted toward that of UGT1A4 with loss of glucuronidation of phenolic substrates. Histidine 17-20 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 118-124 17956868-10 2007 Furthermore, mutation of His-39 residue of UGT1A1 (His-40 in UGT1A4) to proline led to loss of glucuronidation of phenols but not of estrogens. Histidine 25-28 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 61-67 17956868-10 2007 Furthermore, mutation of His-39 residue of UGT1A1 (His-40 in UGT1A4) to proline led to loss of glucuronidation of phenols but not of estrogens. Histidine 51-54 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 61-67 17953656-7 2007 Other studies have shown that replacement of these histidines alpha(1) H101, alpha(2) H101, and alpha(3) H126 by arginine, as naturally present in alpha(4) and alpha(6) , leads to benzodiazepine insensitivity of these receptors. Histidine 51-61 adrenoceptor alpha 1D Homo sapiens 62-69 17932513-6 2007 It causes covalent oxidative crosslinking between the PCNA subunits through a histidine residue in the intersubunit domain. Histidine 78-87 proliferating cell nuclear antigen Homo sapiens 54-58 17928927-7 2007 The soluble His-LKB1 from RG accounted for 34.1% of total proteins and the yield of purified His-LKB1 was approximately 92 microg/ml. Histidine 12-15 serine/threonine kinase 11 Homo sapiens 16-20 17928927-7 2007 The soluble His-LKB1 from RG accounted for 34.1% of total proteins and the yield of purified His-LKB1 was approximately 92 microg/ml. Histidine 93-96 serine/threonine kinase 11 Homo sapiens 97-101 17928927-9 2007 The growth inhibitory ratio of the purified BL-derived and RG-derived His-LKB1 on hepatic carcinoma SMMC-7721 cells was 24.97% and 45.68%, respectively, and both could produce significant cell-cycle arrest. Histidine 70-73 serine/threonine kinase 11 Homo sapiens 74-78 17565994-10 2007 The results of kinetic studies of site-directed mutants of GmIF7GT showed that both His-15 and Asp-125, which correspond to the catalytic residues of UGT71G1 and VvGT1, are not important for GmIF7GT activity. Histidine 84-87 isoflavone 7-O-glucosyltransferase 1 Glycine max 59-66 17567580-6 2007 On the basis of structural analysis, along with site-directed mutagenesis, a mechanism for the enzyme is proposed in which a decarboxylation reaction occurs directly, and the invariant histidine residue in the OHCU decarboxylase family plays an essential role in producing (S)-allantoin through a proton transfer from the hydroxyl group at C4 to C5 at the re-face of OHCU. Histidine 185-194 ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase Homo sapiens 210-228 17668007-4 2007 We show that RRM2 binds to RNA in a new way, by using a tryptophan within a conserved SWQLKD motif that resides on helix alpha1, together with amino acids from strand beta2 and a histidine on loop 5. Histidine 179-188 ribonucleotide reductase regulatory subunit M2 Homo sapiens 13-17 17562347-9 2007 Our finding implicates functional importance of histidine in exchange of arginine at amino acid 481 of transferrin receptor 2 in iron homeostasis. Histidine 48-57 transferrin receptor 2 Homo sapiens 103-125 17567043-9 2007 This form was found to possess an effectively four-coordinate cob(II)alamin species that has neither water nor histidine coordinated to the cobalt center. Histidine 111-120 metabolism of cobalamin associated B Homo sapiens 62-65 25516571-1 2015 The vacuolar Zn(2+)/H(+) antiporter of Arabidopsis thaliana, AtMTP1, has a long cytosolic histidine-rich loop. Histidine 90-99 zinc transporter Arabidopsis thaliana 61-67 25516571-2 2015 A mutated AtMTP1 in which the first half of the loop (His-half) was deleted exhibited a 11-fold higher transport velocity in yeast cells. Histidine 54-57 zinc transporter Arabidopsis thaliana 10-16 25516571-5 2015 The His-half AtMTP1 transported cobalt in a heterologous expression assay in yeast, but the cumulative amount of cobalt in 35S-His-half plants was not increased. Histidine 4-7 zinc transporter Arabidopsis thaliana 13-19 25155647-2 2015 Herein, a straightforward method is demonstrated for efficient encapsidation of magnetic nanoparticles into the engineered virus-like particle (VLP) through the affinity of histidine tags for the nickel- nitrilotriacetic acid (NTA) chelate. Histidine 173-182 VHL like Homo sapiens 144-147 25574816-7 2015 RESULTS: Histone H1.2, which lacks histidine, was phosphorylated by phosphoramidate on several lysine residues, as shown by MS. PHPT1 was shown to dephosphorylate phosphohistone H1 at a rate similar to that previously described for the dephosphorylation of phosphohistidine-containing peptides. Histidine 35-44 H1.2 linker histone, cluster member Homo sapiens 17-21 25761704-7 2015 24 hours after HI, TRPM7 protein level in the ipsilateral hemisphere was significantly higher than in the contralateral hemisphere. Histidine 15-17 transient receptor potential cation channel, subfamily M, member 7 Rattus norvegicus 19-24 25130193-6 2015 We found that polymorphic haplotypes in the MDA-5 gene IFIH1 encoding histidine at position 843 and threonine at position 946 strongly correlate with the resolution of HCV infection (odds ratio [OR]: 16.23; 95% confidence interval [CI]: 3.67-71.87; P = 1.1 x 10(-6) ). Histidine 70-79 interferon induced with helicase C domain 1 Homo sapiens 44-49 25130193-7 2015 Overexpression of MDA-5 genetic variants in HEK 293 cells and in a tissue culture model of HCV infection revealed that the histidine 843/threonine 946 variant leads to increased baseline and ligand-induced expression of interferon-induced genes and confers an increased ability to suppress HCV replication. Histidine 123-132 interferon induced with helicase C domain 1 Homo sapiens 18-23 25522875-4 2015 In this study, by incubating the Escherichia coli-derived His-tagged Oct4 proteins with the whole cell lysates of a variety of human cells followed by retrieving the reacted Oct4 proteins with the Ni-NTA beads, we developed a labor- and cost-effective in vitro PTM method that allowed for mass spectrometric determination of the phosphorylation profiles of Oct4 proteins exposed to various cell-free systems. Histidine 58-61 POU class 5 homeobox 1 Homo sapiens 69-73 17459427-10 2007 In conclusion, multiple extracellular histidine residues (H107, H109, H215 and H419) and threonine residues of the alpha1 and beta Zn(2+) coordination sites are critical for modulation of the glycine receptor by protons. Histidine 38-47 adrenoceptor alpha 1D Homo sapiens 115-130 25522875-4 2015 In this study, by incubating the Escherichia coli-derived His-tagged Oct4 proteins with the whole cell lysates of a variety of human cells followed by retrieving the reacted Oct4 proteins with the Ni-NTA beads, we developed a labor- and cost-effective in vitro PTM method that allowed for mass spectrometric determination of the phosphorylation profiles of Oct4 proteins exposed to various cell-free systems. Histidine 58-61 POU class 5 homeobox 1 Homo sapiens 174-178 25522875-4 2015 In this study, by incubating the Escherichia coli-derived His-tagged Oct4 proteins with the whole cell lysates of a variety of human cells followed by retrieving the reacted Oct4 proteins with the Ni-NTA beads, we developed a labor- and cost-effective in vitro PTM method that allowed for mass spectrometric determination of the phosphorylation profiles of Oct4 proteins exposed to various cell-free systems. Histidine 58-61 POU class 5 homeobox 1 Homo sapiens 174-178 25466186-1 2014 An asparagine or a histidine are present in a similar position in the outer pore region of SK2 and SK3 channels, respectively. Histidine 19-28 potassium calcium-activated channel subfamily N member 3 Homo sapiens 99-102 25325399-1 2014 Growth hormone releasing peptide, GHRP-6, a hexapeptide (His-(D-Trp)-Ala-Trp-(D-Phe)-Lys-NH2, MW = 872.44 Da) that belongs to a class of synthetic growth hormone secretagogues, can stimulate growth hormone secretion from somatotrophs in several species including humans. Histidine 57-60 ghrelin and obestatin prepropeptide Homo sapiens 0-32 25283443-4 2014 Differences in the enantiomeric specificity of d/l-lactacte formation observed for the DJ-1 superfamily proteins are explained by the presence of a His residue in the active site with essential Cys and Glu residues. Histidine 148-151 Parkinsonism associated deglycase Homo sapiens 87-91 17461796-7 2007 In cell lines, PCSK9 also colocalized with the LDLR at the cell surface, requiring the presence of the C-terminal Cys/His-rich domain of PCSK9. Histidine 118-121 proprotein convertase subtilisin/kexin type 9 Homo sapiens 15-20 17461796-7 2007 In cell lines, PCSK9 also colocalized with the LDLR at the cell surface, requiring the presence of the C-terminal Cys/His-rich domain of PCSK9. Histidine 118-121 low density lipoprotein receptor Homo sapiens 47-51 17461796-7 2007 In cell lines, PCSK9 also colocalized with the LDLR at the cell surface, requiring the presence of the C-terminal Cys/His-rich domain of PCSK9. Histidine 118-121 proprotein convertase subtilisin/kexin type 9 Homo sapiens 137-142 25283443-6 2014 The mechanism of DJ-1 glyoxalase provides a basis for understanding the His residue-based stereospecificity. Histidine 72-75 Parkinsonism associated deglycase Homo sapiens 17-21 25438756-4 2014 Initially, we identified and validated PCNA methionine 40 (M40) and histidine 44 (H44) as essential residues for PCNA/PIP-box interactions in general and, more specifically, for efficient PCNA loading onto chromatin within cells. Histidine 68-77 proliferating cell nuclear antigen Homo sapiens 113-117 17126561-7 2007 The specific activity of the purified six-histidine-tagged recombinant PGI (rPGI-His(6)) was approximately 800U/mg of protein. Histidine 42-51 glucose-6-phosphate isomerase Mycobacterium tuberculosis H37Rv 71-74 17355802-2 2007 This study was to express and purify His-hIDO fusion protein and to generate rabbit anti-human IDO polyclonal antibody, which was used to analyze IDO expression in tumor cells. Histidine 37-40 indoleamine 2,3-dioxygenase 1 Homo sapiens 42-45 17182859-4 2007 This was validated by binding in vitro of both purified full-length HIS-tagged GCP6 and a GCP6(1397-1819) fragment to keratins, and pull-down with native IFs. Histidine 68-71 tubulin gamma complex associated protein 6 Homo sapiens 79-83 17157250-0 2006 Histidine phosphorylation of the potassium channel KCa3.1 by nucleoside diphosphate kinase B is required for activation of KCa3.1 and CD4 T cells. Histidine 0-9 NME/NM23 nucleoside diphosphate kinase 2 Homo sapiens 61-92 17157250-4 2006 NDPK-B directly binds and activates KCa3.1 by phosphorylating histidine 358 in the carboxyl terminus of KCa3.1. Histidine 62-71 NME/NM23 nucleoside diphosphate kinase 2 Homo sapiens 0-6 17078101-5 2006 We found that among GSTT1(+) individuals the DEB-induced SCE level was significantly lower when the EPHX 139 codon was His/Arg rather than His/His. Histidine 119-122 epoxide hydrolase 1 Homo sapiens 100-104 17105194-5 2006 Herein we report identification of a conserved Mc b5 core 2 packing motif that plays a key role in stabilizing apoprotein conformation in the vicinity of Trp-22, thereby compensating for the presence of Ser at position 71: a pi-stacking interaction between the side chains of Trp-22 and His-15 that is extended by hydrogen bonding between the side chains of His-15, Ser-20, and Glu-11. Histidine 287-290 cytochrome b5 type A Homo sapiens 47-52 17105194-5 2006 Herein we report identification of a conserved Mc b5 core 2 packing motif that plays a key role in stabilizing apoprotein conformation in the vicinity of Trp-22, thereby compensating for the presence of Ser at position 71: a pi-stacking interaction between the side chains of Trp-22 and His-15 that is extended by hydrogen bonding between the side chains of His-15, Ser-20, and Glu-11. Histidine 358-361 cytochrome b5 type A Homo sapiens 47-52 16769050-2 2006 We have shown that a fragment released from the central histidine/proline-rich (His/Pro-rich) domain of HRGP blocks endothelial cell migration in vitro and vascularization and growth of murine fibrosarcoma in vivo. Histidine 56-65 histidine-rich glycoprotein Mus musculus 104-108 16769050-2 2006 We have shown that a fragment released from the central histidine/proline-rich (His/Pro-rich) domain of HRGP blocks endothelial cell migration in vitro and vascularization and growth of murine fibrosarcoma in vivo. Histidine 80-83 histidine-rich glycoprotein Mus musculus 104-108 16769050-3 2006 The minimal active HRGP domain exerting the anti-angiogenic effect was recently narrowed down to a 35 amino acid peptide, HRGP330, derived from the His/Pro-rich domain of HRGP. Histidine 148-151 histidine-rich glycoprotein Mus musculus 19-23 16769050-3 2006 The minimal active HRGP domain exerting the anti-angiogenic effect was recently narrowed down to a 35 amino acid peptide, HRGP330, derived from the His/Pro-rich domain of HRGP. Histidine 148-151 histidine-rich glycoprotein Mus musculus 122-126 25438756-4 2014 Initially, we identified and validated PCNA methionine 40 (M40) and histidine 44 (H44) as essential residues for PCNA/PIP-box interactions in general and, more specifically, for efficient PCNA loading onto chromatin within cells. Histidine 68-77 proliferating cell nuclear antigen Homo sapiens 113-117 25290245-7 2014 Previously, we reported that the His-rich domain of selenoprotein P (SelP-H) inhibited metal-induced aggregation and toxicity of Abeta, due to its metal chelation ability. Histidine 33-36 selectin P Homo sapiens 69-73 25290245-10 2014 This work implies that the surface-exposed His-rich domain of SelP makes it capable of modulating Cu(+)/Cu(2+)-mediated aggregation and neurotoxicity of both Ass and tau and may play important roles in the prevention of AD progression. Histidine 43-46 selectin P Homo sapiens 62-66 25140899-5 2014 By modulating the amino acid sequence of alpha-synuclein at only two positions in which we introduced a pair of histidine residues found in Abeta, we created a chimeric alpha-synuclein/Abeta peptide with extended ganglioside-binding properties. Histidine 112-121 synuclein alpha Homo sapiens 41-56 25140899-5 2014 By modulating the amino acid sequence of alpha-synuclein at only two positions in which we introduced a pair of histidine residues found in Abeta, we created a chimeric alpha-synuclein/Abeta peptide with extended ganglioside-binding properties. Histidine 112-121 synuclein alpha Homo sapiens 169-184 25068395-3 2014 Here, presteady-state and steady-state kinetics of the PSA-catalyzed hydrolysis of the fluorogenic substrate Mu-His-Ser-Ser-Lys-Leu-Gln-AMC (spanning from pH 6.5 to pH 9.0, at 37.0 C) are reported. Histidine 112-115 kallikrein related peptidase 3 Homo sapiens 55-58 24699373-9 2014 Bap2-mediated leucine import was inhibited by some amino acids according to the following order of severity: phenylalanine, leucine>isoleucine>methionine, tyrosine>valine>tryptophan; histidine and asparagine had no effect. Histidine 195-204 branched-chain amino acid permease BAP2 Saccharomyces cerevisiae S288C 0-4 16766478-2 2006 Both H oximes (HI-6, HLo-7) and the oxime BI-6 were found to be more efficacious reactivators of VX-inhibited acetylcholinesterase than pralidoxime and obidoxime. Histidine 15-17 acetylcholinesterase Rattus norvegicus 110-130 16815950-0 2006 The hpa1 mutant of Arabidopsis reveals a crucial role of histidine homeostasis in root meristem maintenance. Histidine 57-66 histidinol phosphate aminotransferase 1 Arabidopsis thaliana 4-8 16815950-5 2006 Biochemical analysis shows that the mutation in hpa1 only resulted in a 30% reduction in free His content and had no significant impact on the total His content. Histidine 94-97 histidinol phosphate aminotransferase 1 Arabidopsis thaliana 48-52 16815950-8 2006 We have demonstrated that the root meristem failure in the mutant is tightly linked to the reduction in free His content and could be rescued by either exogenous His supplementation or AtHPA1 overexpression. Histidine 109-112 histidinol phosphate aminotransferase 1 Arabidopsis thaliana 185-191 24866374-4 2014 In this study we describe a novel, single-well OGT enzyme assay that utilizes 6 x His-tagged substrates, a chemoselective chemical reaction, and unpurified OGT. Histidine 82-85 O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens 47-50 16545906-7 2006 The cytosolic fraction was obtained from the cerebral cortical tissue following centrifugation at 100,000 x g for 1h and caspase-9 activity was assayed using Ac-Leu-Glu-His-Asp-amino-4-methyl coumarin, a specific fluorogenic substrate for caspase-9. Histidine 169-172 caspase 9 Homo sapiens 121-130 16484588-3 2006 To test the mechanism of its action, we constructed mutant forms of c-Mpl; murine c-Mpl(L490H) dis-played a response to NIP-004, whereas human c-Mpl(H499L) lost this response, indicating that histidine in the transmembrane domain of c-Mpl is essential for its activity. Histidine 192-201 myeloproliferative leukemia virus oncogene Mus musculus 68-73 16484588-3 2006 To test the mechanism of its action, we constructed mutant forms of c-Mpl; murine c-Mpl(L490H) dis-played a response to NIP-004, whereas human c-Mpl(H499L) lost this response, indicating that histidine in the transmembrane domain of c-Mpl is essential for its activity. Histidine 192-201 myeloproliferative leukemia virus oncogene Mus musculus 82-87 24829455-2 2014 However, recent analysis of an Exo1-E109K knockin mouse has concluded that Exo1 function in mammalian mismatch repair is restricted to a structural role, a conclusion based on a prior report that N-terminal His-tagged Exo1-E109K is hydrolytically defective. Histidine 207-210 exonuclease 1 Homo sapiens 75-79 24736394-5 2014 We further mapped the interaction regions to the 1-9 armadillo repeats of beta-catenin and the BTB domain of KCTD1, especially Position Ala-30 and His-33. Histidine 147-150 catenin beta 1 Homo sapiens 74-86 24293060-5 2014 The nucleotide change results in the substitution of an evolutionarily highly conserved tyrosine by histidine (p.Y689H) in the M41 peptidase domain of AFG3L2. Histidine 100-109 AFG3 like matrix AAA peptidase subunit 2 Homo sapiens 151-157 24606199-0 2014 Imidazole C-2 hydrogen/deuterium exchange reaction at histidine for probing protein structure and function with matrix-assisted laser desorption ionization mass spectrometry. Histidine 54-63 complement C2 Homo sapiens 10-13 24548272-1 2014 In eukaryotes, the tRNA(His) guanylyltransferase (Thg1) catalyzes 3"-5" addition of a single guanosine residue to the -1 position (G-1) of tRNA(His), across from a highly conserved adenosine at position 73 (A73). Histidine 24-27 tRNA guanylyltransferase Saccharomyces cerevisiae S288C 50-54 16597698-9 2006 GUP1 function depends on the active site histidine of the MBOAT motif. Histidine 41-50 O-acyltransferase Saccharomyces cerevisiae S288C 0-4 16625026-4 2006 We show here that Thg1 is >10,000-fold more selective for its cognate substrate tRNA(His) than for the noncognate substrate tRNA(Phe). Histidine 88-91 tRNA guanylyltransferase Saccharomyces cerevisiae S288C 18-22 17197349-9 2006 Other than histidine 118 residue (amino acid sequence 118: histidine) concerned with NDP kinase activity of nm23-H1, serine 120 (amino acid sequence 120: serine) related activity of histidine-dependent protein phosphotransfer was recently reported to be responsible for its biological suppressive effects. Histidine 59-68 cytidine/uridine monophosphate kinase 2 Homo sapiens 85-95 16690078-7 2006 Therefore the Fab fragment of 9F8 was cloned and recombinant 9F8 Fab (rFab) was purified from E. coli periplasmic fraction using a C-terminal His tag. Histidine 142-145 FA complementation group B Homo sapiens 65-68 16647063-0 2006 A critical role for the histidine residues in the catalytic function of acyl-CoA:cholesterol acyltransferase catalysis: evidence for catalytic difference between ACAT1 and ACAT2. Histidine 24-33 acetyl-CoA acetyltransferase 1 Homo sapiens 72-108 16647063-7 2006 These results demonstrate that the histidine residues located at the active site are very crucial both for the catalytic activity of the enzyme and for distinguishing ACAT1 from ACAT2 with respect to enzyme catalysis and substrate specificity. Histidine 35-44 acetyl-CoA acetyltransferase 1 Homo sapiens 167-172 16579629-4 2006 To begin to address this problem, we developed an affinity pull-down/mass spectrometry method to characterize the primary structure of histidine-tagged alpha-synuclein isolated from catecholaminergic neurons. Histidine 135-144 synuclein alpha Homo sapiens 152-167 24422557-3 2014 The first step is the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-l-methionine (SAM) to the histidine residue of EF2, forming a C-C bond. Histidine 110-119 eukaryotic translation elongation factor 2 Homo sapiens 131-134 23932357-1 2014 Increasing concentration of histidine significantly increased stearidonic acid production and cell growth in oleaginous Saccharomyces cerevisiae that has been genetically modified by Deltasnf2 disruption, DGA1 and Delta6 desaturase gene overexpression, and LEU2 expression. Histidine 28-37 diacylglycerol O-acyltransferase Saccharomyces cerevisiae S288C 205-209 23679855-4 2013 Huprine W in hAChE and tacrine in hBChE reside in strikingly similar positions highlighting the conservation of key interactions, namely, pi-pi/cation-pi interactions with Trp86 (Trp82), and hydrogen bonding with the main chain carbonyl of the catalytic histidine residue. Histidine 254-263 butyrylcholinesterase Homo sapiens 34-39 23652332-5 2013 Here, we reported that the His-rich domain of selenoprotein P (SelP-H) and the Sec-to-Cys mutant selenoprotein M (SelM") are capable of binding transition metal ions and modulating the Zn(2+)-mediated Abeta aggregation, ROS production and neurotoxicity. Histidine 27-30 selectin P Homo sapiens 63-67 22961760-0 2013 Disruption of the histidine triad nucleotide-binding hint2 gene in mice affects glycemic control and mitochondrial function. Histidine 18-27 histidine triad nucleotide binding protein 2 Mus musculus 53-58 22961760-1 2013 UNLABELLED: The histidine triad nucleotide-binding (HINT2) protein is a mitochondrial adenosine phosphoramidase expressed in the liver and pancreas. Histidine 16-25 histidine triad nucleotide binding protein 2 Mus musculus 52-57 23772397-0 2013 Zinc-binding and structural properties of the histidine-rich loop of Arabidopsis thaliana vacuolar membrane zinc transporter MTP1. Histidine 46-55 zinc transporter Arabidopsis thaliana 125-129 23772397-1 2013 The vacuolar Zn(2+)/H(+) antiporter of Arabidopsis thaliana, AtMTP1, has a cytosolic histidine-rich loop (His-loop). Histidine 85-94 zinc transporter Arabidopsis thaliana 61-67 23772397-1 2013 The vacuolar Zn(2+)/H(+) antiporter of Arabidopsis thaliana, AtMTP1, has a cytosolic histidine-rich loop (His-loop). Histidine 106-109 zinc transporter Arabidopsis thaliana 61-67 23510298-0 2013 Involvement of histidine residues in the pH-dependent beta-galactoside binding activity of human galectin-1. Histidine 15-24 galectin 1 Homo sapiens 97-107 16212555-2 2006 TrZnT-1 (T. rubripes ZnT-1) shares overall topology with other members of the ZnT-1 family of zinc transporters, with six TMs (transmembrane domains) including a large histidine-rich intracellular loop between TM IV and V and intracellular C- and N-termini. Histidine 168-177 zinc transporter 1 Takifugu rubripes 0-7 16212555-2 2006 TrZnT-1 (T. rubripes ZnT-1) shares overall topology with other members of the ZnT-1 family of zinc transporters, with six TMs (transmembrane domains) including a large histidine-rich intracellular loop between TM IV and V and intracellular C- and N-termini. Histidine 168-177 zinc transporter 1 Takifugu rubripes 2-7 16212555-2 2006 TrZnT-1 (T. rubripes ZnT-1) shares overall topology with other members of the ZnT-1 family of zinc transporters, with six TMs (transmembrane domains) including a large histidine-rich intracellular loop between TM IV and V and intracellular C- and N-termini. Histidine 168-177 zinc transporter 1 Takifugu rubripes 21-26 16251206-5 2006 We have found that the Escherichia coli nucleotide excision enzyme UvrABC nuclease is able to incise Cr(III)- and Cr(III)-histidine-modified plasmid DNA and the extent of incision is proportional to the amount of Cr(III)-DNA adducts in the plasmid. Histidine 122-131 nuclease Escherichia coli 74-82 26105914-8 2013 Furthermore we could show a fourfold reduction to encounter severe course of preeclampsia (defined as occurrence of HELLP-syndrome or eclampsia) in carriers of the EPHX1 polymorphism encoding histidine. Histidine 192-201 epoxide hydrolase 1 Homo sapiens 164-169 23231502-5 2013 Incubation of purified Pin1 with HNE followed by MALDI-TOF/TOF mass spectrometry resulted in detection of Michael adducts at the active site residues His-157 and Cys-113. Histidine 150-153 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 Homo sapiens 23-27 23212911-0 2013 The pH sensitivity of murine heat shock protein 47 (HSP47) binding to collagen is affected by mutations in the breach histidine cluster. Histidine 118-127 serine (or cysteine) peptidase inhibitor, clade H, member 1 Mus musculus 29-50 23212911-0 2013 The pH sensitivity of murine heat shock protein 47 (HSP47) binding to collagen is affected by mutations in the breach histidine cluster. Histidine 118-127 serine (or cysteine) peptidase inhibitor, clade H, member 1 Mus musculus 52-57 23212911-3 2013 HSP47 binds procollagen at a neutral pH but releases at a pH similar to the pK(a) of the imidazole side chain of histidine residues. Histidine 113-122 serine (or cysteine) peptidase inhibitor, clade H, member 1 Mus musculus 0-5 23212911-5 2013 Murine HSP47 has 14 histidine residues grouped into three clusters, known as the breach, gate, and shutter. Histidine 20-29 serine (or cysteine) peptidase inhibitor, clade H, member 1 Mus musculus 7-12 23212911-6 2013 Here, we report the use of histidine mutagenesis to demonstrate the relative contribution of these three clusters to HSP47 structure and the "pH switch." Histidine 27-36 serine (or cysteine) peptidase inhibitor, clade H, member 1 Mus musculus 117-122 23212911-9 2013 Thus, His-198, His-197 and His-191 are important (if not central) to HSP47 mechanism of binding/release to collagen. Histidine 6-9 serine (or cysteine) peptidase inhibitor, clade H, member 1 Mus musculus 69-74 23212911-9 2013 Thus, His-198, His-197 and His-191 are important (if not central) to HSP47 mechanism of binding/release to collagen. Histidine 15-18 serine (or cysteine) peptidase inhibitor, clade H, member 1 Mus musculus 69-74 23212911-9 2013 Thus, His-198, His-197 and His-191 are important (if not central) to HSP47 mechanism of binding/release to collagen. Histidine 15-18 serine (or cysteine) peptidase inhibitor, clade H, member 1 Mus musculus 69-74 22967951-6 2013 MsrA adsorbs on the hydrophobic carbon electrode surface preferentially through the three hydrophobic domains, C1, C2 and C3, which contain the tyrosine, tryptophan and histidine residues, and tryptophan exists only in these regions, and undergo electrochemical oxidation. Histidine 169-178 heterogeneous nuclear ribonucleoprotein C Homo sapiens 111-124 23653868-6 2013 The most informative results were obtained with the exon 4 flanking primers and the Cac8I restriction enzyme, which generated a 253 bp product that carries the ACVR1 617G>A mutation, which causes an amino acid substitution of histidine for arginine at position 206 of the glycine-serine (GS) domain, and its mutation results in the dysregulation of bone morphogenetic protein (BMP) signalling that causes FOP. Histidine 229-238 bone morphogenetic protein 1 Homo sapiens 352-378 16508238-10 2006 A Hitrap-mouse recombinant His-tag-saposin A antibody column bound NPF, pulled down the NPF activity in TCGF, and the antibody recognized a 16kDa molecule in western-blotting of TCGF. Histidine 27-30 interleukin 2 Mus musculus 104-108 16508238-10 2006 A Hitrap-mouse recombinant His-tag-saposin A antibody column bound NPF, pulled down the NPF activity in TCGF, and the antibody recognized a 16kDa molecule in western-blotting of TCGF. Histidine 27-30 interleukin 2 Mus musculus 178-182 16377633-7 2006 These findings indicate that His-191 in the S3-S4 loop is a critical residue conferring nickel block to Ca(v)3.2 and reveal a novel role for the S3-S4 loop to control ion permeation through T-type Ca2+ channels. Histidine 29-32 immunoglobulin lambda variable 7-43 Homo sapiens 104-112 16395674-2 2006 In knockout mice mismatch-repair (MMR) defects or inactivation of the fragile histidine triad (FHIT) gene are associated with MTS-like signs, including SGC. Histidine 78-87 serglycin Mus musculus 152-155 16420561-5 2006 METHODS AND RESULTS: A recombinant VWF substrate containing the ADAMTS-13 cleavage site and a 6X Histidine tag was cleaved by ADAMTS-13 in a dose-dependent manner, generating approximately 7739 Da peptide containing a 6X Histidine tag. Histidine 97-106 ADAM metallopeptidase with thrombospondin type 1 motif 13 Homo sapiens 126-135 16420561-5 2006 METHODS AND RESULTS: A recombinant VWF substrate containing the ADAMTS-13 cleavage site and a 6X Histidine tag was cleaved by ADAMTS-13 in a dose-dependent manner, generating approximately 7739 Da peptide containing a 6X Histidine tag. Histidine 221-230 ADAM metallopeptidase with thrombospondin type 1 motif 13 Homo sapiens 64-73 16420561-5 2006 METHODS AND RESULTS: A recombinant VWF substrate containing the ADAMTS-13 cleavage site and a 6X Histidine tag was cleaved by ADAMTS-13 in a dose-dependent manner, generating approximately 7739 Da peptide containing a 6X Histidine tag. Histidine 221-230 ADAM metallopeptidase with thrombospondin type 1 motif 13 Homo sapiens 126-135 21204476-14 2006 Erf2p and Akr1p are integral membrane proteins harboring a cysteine-rich domain containing a conserved DHHC (Asp-His-His-Cys) motif. Histidine 113-116 palmitoyltransferase ERF2 Saccharomyces cerevisiae S288C 0-5 16249174-2 2005 PTOX and AOX are diiron carboxylate proteins, and based on crystal structures of other members of this protein class, a structural model of PTOX has been proposed in which the ligation sphere of the diiron center is composed of six conserved histidine and glutamate residues. Histidine 242-251 Alternative oxidase family protein Arabidopsis thaliana 0-4 16249174-2 2005 PTOX and AOX are diiron carboxylate proteins, and based on crystal structures of other members of this protein class, a structural model of PTOX has been proposed in which the ligation sphere of the diiron center is composed of six conserved histidine and glutamate residues. Histidine 242-251 Alternative oxidase family protein Arabidopsis thaliana 140-144 16186124-4 2005 Like other 2OG oxygenases, PAHX possesses a double-stranded beta-helix core, which supports three iron binding ligands (His(175), Asp(177), and His(264)); the 2-oxoacid group of 2OG binds to the Fe(II) in a bidentate manner. Histidine 120-123 phytanoyl-CoA 2-hydroxylase Homo sapiens 27-31 16186124-4 2005 Like other 2OG oxygenases, PAHX possesses a double-stranded beta-helix core, which supports three iron binding ligands (His(175), Asp(177), and His(264)); the 2-oxoacid group of 2OG binds to the Fe(II) in a bidentate manner. Histidine 144-147 phytanoyl-CoA 2-hydroxylase Homo sapiens 27-31 16186124-5 2005 The manner in which PAHX binds to Fe(II) and 2OG together with the presence of a cysteine residue (Cys(191)) 6.7 A from the Fe(II) and two further histidine residues (His(155) and His(281)) at its active site distinguishes it from that of the other human 2OG oxygenase for which structures are available, factor inhibiting hypoxia-inducible factor. Histidine 167-170 phytanoyl-CoA 2-hydroxylase Homo sapiens 20-24 16186124-5 2005 The manner in which PAHX binds to Fe(II) and 2OG together with the presence of a cysteine residue (Cys(191)) 6.7 A from the Fe(II) and two further histidine residues (His(155) and His(281)) at its active site distinguishes it from that of the other human 2OG oxygenase for which structures are available, factor inhibiting hypoxia-inducible factor. Histidine 180-183 phytanoyl-CoA 2-hydroxylase Homo sapiens 20-24 16186124-6 2005 Of the 15 PAHX residues observed to be mutated in RD patients, 11 cluster in two distinct groups around the Fe(II) (Pro(173), His(175), Gln(176), Asp(177), and His(220)) and 2OG binding sites (Trp(193), Glu(197), Ile(199), Gly(204), Asn(269), and Arg(275)). Histidine 126-129 phytanoyl-CoA 2-hydroxylase Homo sapiens 10-14 16186124-6 2005 Of the 15 PAHX residues observed to be mutated in RD patients, 11 cluster in two distinct groups around the Fe(II) (Pro(173), His(175), Gln(176), Asp(177), and His(220)) and 2OG binding sites (Trp(193), Glu(197), Ile(199), Gly(204), Asn(269), and Arg(275)). Histidine 160-163 phytanoyl-CoA 2-hydroxylase Homo sapiens 10-14 16338409-1 2005 The structure of A. thaliana imidazoleglycerol-phosphate dehydratase, an enzyme of histidine biosynthesis and a target for the triazole phosphonate herbicides, has been determined to 3.0 A resolution. Histidine 83-92 imidazoleglycerol-phosphate dehydratase Arabidopsis thaliana 29-68 16274251-5 2005 Interestingly, a histidine outside the central polyproline motif contributes significantly to Lck SH3 binding affinity and specificity. Histidine 17-26 LCK proto-oncogene, Src family tyrosine kinase Homo sapiens 94-97 16141206-0 2005 Two conserved histidine residues are critical to the function of the TagF-like family of enzymes. Histidine 14-23 CDP-glycerol:polyglycerol phosphate glycero-phosphotransferase (poly(glycerol phosphate) polymerase) Bacillus subtilis subsp. subtilis str. 168 69-73 16141206-5 2005 Alteration of histidine residues 474 and 612 by site-directed mutagenesis abolished TagF activity in vitro (5000-fold reduction in k(cat)/K(m)) while variants in four other conserved acidic residues showed minimal loss of activity. Histidine 14-23 CDP-glycerol:polyglycerol phosphate glycero-phosphotransferase (poly(glycerol phosphate) polymerase) Bacillus subtilis subsp. subtilis str. 168 84-88 16176589-3 2005 Serine lipases, acetylcholinesterase, butyrylcholinesterase, and cholesterol esterase belong to a large family of proteins called the alpha/beta-hydrolase fold, and they share the same catalytic machinery as serine proteases in that they have an active site serine residue which, with a histidine and an aspartic or glutamic acid, forms a catalytic triad. Histidine 287-296 carboxyl ester lipase Homo sapiens 0-85 23653868-6 2013 The most informative results were obtained with the exon 4 flanking primers and the Cac8I restriction enzyme, which generated a 253 bp product that carries the ACVR1 617G>A mutation, which causes an amino acid substitution of histidine for arginine at position 206 of the glycine-serine (GS) domain, and its mutation results in the dysregulation of bone morphogenetic protein (BMP) signalling that causes FOP. Histidine 229-238 bone morphogenetic protein 1 Homo sapiens 380-383 23405232-4 2013 Previous studies have shown that SEB stimulates a more potent activation of T lymphocytes than SEC3, and mutations of the histidine residues eliminated the toxicity of SEB. Histidine 122-131 seborrheic dermatitis Mus musculus 168-171 16027123-7 2005 Protonation of two histidine residues (His83 and His87) in helix C of hGM-CSF appears to act as a pH-dependent molecular switch to control the interaction with GAGs. Histidine 19-28 colony stimulating factor 2 Homo sapiens 70-77 16511155-1 2005 Imidazoleglycerol-phosphate dehydratase catalyses the sixth step of the histidine-biosynthesis pathway in plants and microorganisms and has been identified as a possible target for the development of novel herbicides. Histidine 72-81 imidazoleglycerol-phosphate dehydratase Arabidopsis thaliana 0-39 15930519-7 2005 Site-directed mutagenesis was used to support proposals for the identity of the iron binding ligands (His-175, Asp-177, His-264) of the 2-His-1-carboxylate motif of PAHX. Histidine 102-105 phytanoyl-CoA 2-hydroxylase Homo sapiens 165-169 15930519-7 2005 Site-directed mutagenesis was used to support proposals for the identity of the iron binding ligands (His-175, Asp-177, His-264) of the 2-His-1-carboxylate motif of PAHX. Histidine 120-123 phytanoyl-CoA 2-hydroxylase Homo sapiens 165-169 23172351-2 2012 We recently reported that NIa efficiently cleaved the amyloid-beta (Abeta) peptide, which contains the sequence Val-His-His-Gln in the vicinity of the cleavage site by alpha-secretase, and that the expression of NIa using a lentiviral system in the brain of AD mouse model reduced plaque deposition levels. Histidine 116-119 amyloid beta (A4) precursor protein Mus musculus 68-73 23172351-2 2012 We recently reported that NIa efficiently cleaved the amyloid-beta (Abeta) peptide, which contains the sequence Val-His-His-Gln in the vicinity of the cleavage site by alpha-secretase, and that the expression of NIa using a lentiviral system in the brain of AD mouse model reduced plaque deposition levels. Histidine 120-123 amyloid beta (A4) precursor protein Mus musculus 68-73 23105118-0 2012 The M2 module of the Cys-His-rich domain (CHRD) of PCSK9 protein is needed for the extracellular low-density lipoprotein receptor (LDLR) degradation pathway. Histidine 25-28 proprotein convertase subtilisin/kexin type 9 Homo sapiens 51-56 23105118-0 2012 The M2 module of the Cys-His-rich domain (CHRD) of PCSK9 protein is needed for the extracellular low-density lipoprotein receptor (LDLR) degradation pathway. Histidine 25-28 low density lipoprotein receptor Homo sapiens 97-129 23105118-0 2012 The M2 module of the Cys-His-rich domain (CHRD) of PCSK9 protein is needed for the extracellular low-density lipoprotein receptor (LDLR) degradation pathway. Histidine 25-28 low density lipoprotein receptor Homo sapiens 131-135 22906720-0 2012 A role for His-160 in peroxide inhibition of S. cerevisiae S-formylglutathione hydrolase: evidence for an oxidation sensitive motif. Histidine 11-14 S-formylglutathione hydrolase Saccharomyces cerevisiae S288C 59-88 15905212-3 2005 Swapping the divergent histidine (H107) residue in GlyR alpha1, which together with the conserved H109 forms part of an intersubunit Zn2+-binding site, for the equivalent asparagine residue present in GlyR alpha2 and alpha3, reversed this phenotype. Histidine 23-32 glycine receptor alpha 1 Homo sapiens 51-62 19565007-5 2005 A G --> A single nucleotide polymorphism, which causes an arginine (R) to be replaced with histidine (H) at position 131, defines two allotypes which difer in their avidity for complexed human IgG(2) and IgG(3). Histidine 94-103 immunoglobulin heavy constant gamma 3 (G3m marker) Homo sapiens 207-213 16004422-6 2005 Oriented coupling of the Fab fragments on chelate-epoxy cellulose via a C-terminal histidine tag, however, increased the adsorption capacity to 178.3 +/- 8.6 pg TNF/mg adsorbent wet weight. Histidine 83-92 FA complementation group B Homo sapiens 25-28 15952772-5 2005 Using the microdialysis ATR-FTIR setup, we determined that a histidine and the carboxylate group of a glutamate are involved in Zn(2+) binding. Histidine 61-70 ATR serine/threonine kinase Equus caballus 24-27 15977068-0 2005 GABAA receptor-associated protein (GABARAP) induces apoptosis by interacting with DEAD (Asp-Glu-Ala-Asp/His) box polypeptide 47 (DDX 47). Histidine 104-107 GABA type A receptor-associated protein Homo sapiens 0-33 15977068-0 2005 GABAA receptor-associated protein (GABARAP) induces apoptosis by interacting with DEAD (Asp-Glu-Ala-Asp/His) box polypeptide 47 (DDX 47). Histidine 104-107 GABA type A receptor-associated protein Homo sapiens 35-42 15977068-0 2005 GABAA receptor-associated protein (GABARAP) induces apoptosis by interacting with DEAD (Asp-Glu-Ala-Asp/His) box polypeptide 47 (DDX 47). Histidine 104-107 DEAD-box helicase 47 Homo sapiens 129-135 15849306-4 2005 The predicted GL1 protein includes three histidine-rich domains, the landmark of a family of membrane-bound desaturases/hydroxylases, including fatty acid-modifying enzymes. Histidine 41-50 glossy 1 Zea mays 14-17 15664159-5 2005 RTA also autoregulated its own polyubiquitination and stability, and both activities were abolished by point mutations in a Cys plus His-rich N-terminal domain. Histidine 133-136 MAS related GPR family member F Homo sapiens 0-3 15489893-2 2004 The ST18 gene encodes a zinc-finger DNA-binding protein with six fingers of the C2HC type (configuration Cys-X5-Cys-X12-His-X4-Cys) and an SMC domain. Histidine 120-123 ST18 C2H2C-type zinc finger transcription factor Homo sapiens 4-8 15564475-7 2004 However, the recognition of this exposed epitope by an anti-HBc antibody appeared to be affected by the I97E mutation or by histidine tagging at the C terminus of mutant HBcAg, which is presumably in the capsid interior. Histidine 124-133 keratin 88, pseudogene Homo sapiens 60-63 18404403-5 2004 Amino acid substitutions at His-132, located in the third transmembrane domain (TM3) of the hP2Y(1) receptor, delayed the onset of channel opening, but not the kinetics of the activation process. Histidine 28-31 purinergic receptor P2Y1 Homo sapiens 92-108 18404403-7 2004 Replacement of His-132 in the hP2Y(1) receptor with either Ala or Phe increased Zn(2+) sensitivity of the T(in) current. Histidine 15-18 purinergic receptor P2Y1 Homo sapiens 30-46 15375167-5 2004 In silico modeling followed by mutagenesis and the in vitro and cell-based binding studies showed that the His(171)-Glu-Lys-Gln-Ala-Asp(176) and Val(223)-Arg-Asn(224) peptide sequences of MT1-MMP are directly involved in the binding with C1q. Histidine 107-110 complement C1q A chain Homo sapiens 238-241 15520806-4 2004 Erf2 and Akr1 are integral membrane proteins that contain a cysteine-rich domain and an Asp-His-His-Cys motif, both of which catalyse acylation at the carboxyl terminus of their target proteins. Histidine 92-95 palmitoyltransferase ERF2 Saccharomyces cerevisiae S288C 0-4 22981363-3 2012 The equivalent position in UGT1A4 is also known to influence enzyme activity, whilst an N-terminal domain histidine (His37 in UGT1A9) is believed to function as the catalytic base in most UGT enzymes. Histidine 106-115 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 27-33 22945239-1 2012 Human mitochondrial protein mitoNEET is a novel target of type II diabetes drug pioglitazone, and contains a redox active [2Fe-2S] cluster that is hosted by a unique ligand arrangement of three cysteine and one histidine residues. Histidine 211-220 CDGSH iron sulfur domain 1 Homo sapiens 28-36 22955034-7 2012 Deduced amino acid sequences of two putative genes showed that VlFAD2s show high similarity to Arabidopsis FAD2 and commonly contain six transmembrane domain, three histidine boxes and endoplasmic reticulum (ER) retrieval motif representing the characteristics of fatty acid desaturase. Histidine 165-174 fatty acid desaturase 2 Arabidopsis thaliana 65-69 15313223-1 2004 In comparison with the amino acid sequences of seven species of glucosyltransferases and six species of galactosyltransferases, glutamine and histidine are highly conserved as the last amino acid residue of a glycosyltransferase-specific conserved region (UDPGT) in glucosyltransferases and galactosyltransferases, respectively. Histidine 142-151 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 256-261 15355340-5 2004 Here we report that 48 h after induction with methanol, soluble Gas1p was produced at a yield of approximately 10 mg x L(-1) of medium, and this value was unaffected by the further removal of the serine-rich region or by fusion to a 6 x His tag. Histidine 237-240 1,3-beta-glucanosyltransferase GAS1 Saccharomyces cerevisiae S288C 64-69 22743102-7 2012 Sequence analyses establish that while both PRO(FUR) and PRO(PC1) are enriched in histidines when compared with cognate catalytic domains and prokaryotic orthologs, histidine content in PRO(FUR) is ~2-fold greater than that in PRO(PC1), which may augment its pH sensitivity. Histidine 82-92 proprotein convertase subtilisin/kexin type 1 Homo sapiens 61-64 22743102-7 2012 Sequence analyses establish that while both PRO(FUR) and PRO(PC1) are enriched in histidines when compared with cognate catalytic domains and prokaryotic orthologs, histidine content in PRO(FUR) is ~2-fold greater than that in PRO(PC1), which may augment its pH sensitivity. Histidine 82-91 proprotein convertase subtilisin/kexin type 1 Homo sapiens 61-64 22930753-9 2012 Our results suggest that external Zn(2+) regulates ENaC activity by binding to multiple extracellular sites within the gamma-subunit, including (i) a high-affinity stimulatory site within the finger subdomain involving His(193), His(200), and His(202) and (ii) a low-affinity Zn(2+) inhibitory site within the palm subdomain that includes His(88) and Asp(516). Histidine 219-222 sodium channel, nonvoltage-gated 1 alpha Mus musculus 51-55 15791490-7 2004 The recombinant protein of flounder ODC containing a short histidine tag at the carboxyl terminus was overexpressed in Escherichia coli BL21 (DE3) codon plus using an inducible T7 expression system, and was purified by Ni-NTA affinity chromatography. Histidine 59-68 ornithine decarboxylase 1 Danio rerio 36-39 22930753-9 2012 Our results suggest that external Zn(2+) regulates ENaC activity by binding to multiple extracellular sites within the gamma-subunit, including (i) a high-affinity stimulatory site within the finger subdomain involving His(193), His(200), and His(202) and (ii) a low-affinity Zn(2+) inhibitory site within the palm subdomain that includes His(88) and Asp(516). Histidine 229-232 sodium channel, nonvoltage-gated 1 alpha Mus musculus 51-55 22739622-7 2012 Since repeated administration of L-histidine (a precursor of histamine) to Wt mice also showed the same effects, our observations suggested that OCT3 is the molecule responsible for clearance of ischemia-induced histamine in the brain and targeted disruption of Oct3 ameliorated ischemic brain damage through an increase in regulatory T cells. Histidine 33-44 solute carrier family 22 (organic cation transporter), member 3 Mus musculus 145-149 22907071-2 2012 A genetically introduced His-tag arm stretches out of the central structure of a C(2)-symmetric homodimer of glutathione S-transferase, which is used as a linker to recruit a second building block through interprotein metal coordination, forming self-assembled one-dimensional nanostructures with excellent enzymatic activity. Histidine 25-28 glutathione S-transferase kappa 1 Homo sapiens 109-134 22632602-1 2012 The proximal cavity mutant of myoglobin consists of a mutation of the proximal histidine to glycine (H93G), which permits exogenous ligands to bind to the heme iron. Histidine 79-88 myoglobin Homo sapiens 30-39 22780202-0 2012 Viscoelasticity of thin biomolecular films: a case study on nucleoporin phenylalanine-glycine repeats grafted to a histidine-tag capturing QCM-D sensor. Histidine 115-124 ArfGAP with FG repeats 2 Homo sapiens 60-71 22904127-5 2012 We detected 31 (41.9%) heterozygous IDH1 mutations resulting in arginine-to-histidine substitution (R132H;CGT-CAT). Histidine 76-85 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 36-40 15367352-8 2004 Western blot analysis showed that the anti-PRL-2 polyclonal antibody can recognize 6 x His-PRL-2 fusion protein. Histidine 87-90 protein tyrosine phosphatase 4A2 Homo sapiens 43-48 15367352-8 2004 Western blot analysis showed that the anti-PRL-2 polyclonal antibody can recognize 6 x His-PRL-2 fusion protein. Histidine 87-90 protein tyrosine phosphatase 4A2 Homo sapiens 91-96 15313924-1 2004 The antiangiogenic activity of the multidomain plasma protein histidine-proline-rich glycoprotein (HPRG) is localized to its histidine-proline-rich (H/P) domain and has recently been shown to be mediated, at least partially, through binding to cell-surface tropomyosin in fibroblast growth factor-2-activated endothelial cells (X. Guan et al., Thromb Haemost, in press). Histidine 62-71 histidine-rich glycoprotein Mus musculus 99-103 15272307-1 2004 Mammalian formiminotransferase cyclodeaminase (FTCD), a 0.5 million Dalton homo-octameric enzyme, plays important roles in coupling histidine catabolism with folate metabolism and integrating the Golgi complex with the vimentin intermediate filament cytoskeleton. Histidine 132-141 vimentin Homo sapiens 219-227 15481890-5 2004 The DNA sequence of the alpha1 gene revealed a C-->G transversion at position 89, changing the local positively charged histidine to a neutral glutamine. Histidine 123-132 adrenoceptor alpha 1D Homo sapiens 24-30 21812836-10 2012 The concomittant presence of low concentrations of histidine, alanine and either glycine or pyrrolidone-5-carboxylic acid (PCA) in the SC was associated with FLG mutations with 92% specificity. Histidine 51-60 filaggrin Homo sapiens 158-161 22520078-10 2012 Individual mutations at diverse sites within AtMTP1 conferred Co and Cd tolerance in yeast, and included deletions in N-terminal and His-rich intra-molecular cytosolic domains, and mutations of single residues flanking the transmembrane pore or participating in intra- or inter-molecular domain interactions, all of which are not conserved in the non-selective EcYiiP. Histidine 133-136 zinc transporter Arabidopsis thaliana 45-51 22434504-6 2012 The activity of gp74 in the presence of Ni(2+) is significantly decreased below neutral pH, suggesting the presence of one or more His residues in metal binding and/or DNA digestion. Histidine 132-135 Gp74 Escherichia phage HK97 16-20 22542587-5 2012 Most of the expressed human ATAD3A-Myc-HIS co-purified with the yeast mitochondrial fraction thus suggesting that targeting to this organelle is preserved in yeast. Histidine 39-42 MYC proto-oncogene, bHLH transcription factor Homo sapiens 35-38 22542587-8 2012 By contrast, urea-denaturated ATAD3A-Myc-HIS bound to agarose-nickel beads and could be renatured and eluted to obtain highly pure ATAD3A-Myc-HIS. Histidine 41-44 MYC proto-oncogene, bHLH transcription factor Homo sapiens 37-40 22542587-8 2012 By contrast, urea-denaturated ATAD3A-Myc-HIS bound to agarose-nickel beads and could be renatured and eluted to obtain highly pure ATAD3A-Myc-HIS. Histidine 41-44 MYC proto-oncogene, bHLH transcription factor Homo sapiens 138-141 22451660-7 2012 Each of the six FAD2 substitutions was individually converted back to the FADX equivalent identifying residues 111 and 115, adjacent to the first histidine box, as key determinants of conjugase product partitioning. Histidine 146-155 fatty acid desaturase 2 Arabidopsis thaliana 16-20 22451665-3 2012 Utilizing biophysical and biochemical methods, we characterized two independent domains, Ala-35-Lys-124 and His-291-Gly-382, on the TRPM3 N terminus, responsible for interactions with the Ca(2+)-binding proteins calmodulin (CaM) and S100A1. Histidine 108-111 transient receptor potential cation channel subfamily M member 3 Homo sapiens 132-137 22468687-5 2012 Additionally these membranes isolate His-tagged COP9 signalosome complex subunit 8 from cell extracts and show >90% recovery of His-tagged ubiquitin. Histidine 37-40 COP9 signalosome subunit 8 Homo sapiens 48-52 22468687-5 2012 Additionally these membranes isolate His-tagged COP9 signalosome complex subunit 8 from cell extracts and show >90% recovery of His-tagged ubiquitin. Histidine 131-134 COP9 signalosome subunit 8 Homo sapiens 48-52 22034099-8 2012 In an analysis involving recombinant His-DDX3 and His-DDX5, PP2A pretreatment of His-DDX5 increased the interaction with endogenous DDX3, and vice versa. Histidine 37-40 protein phosphatase 2 phosphatase activator Homo sapiens 60-64 22034099-8 2012 In an analysis involving recombinant His-DDX3 and His-DDX5, PP2A pretreatment of His-DDX5 increased the interaction with endogenous DDX3, and vice versa. Histidine 37-40 DEAD-box helicase 5 Homo sapiens 85-89 22034099-8 2012 In an analysis involving recombinant His-DDX3 and His-DDX5, PP2A pretreatment of His-DDX5 increased the interaction with endogenous DDX3, and vice versa. Histidine 50-53 DEAD-box helicase 5 Homo sapiens 54-58 22034099-8 2012 In an analysis involving recombinant His-DDX3 and His-DDX5, PP2A pretreatment of His-DDX5 increased the interaction with endogenous DDX3, and vice versa. Histidine 50-53 protein phosphatase 2 phosphatase activator Homo sapiens 60-64 22034099-8 2012 In an analysis involving recombinant His-DDX3 and His-DDX5, PP2A pretreatment of His-DDX5 increased the interaction with endogenous DDX3, and vice versa. Histidine 50-53 DEAD-box helicase 5 Homo sapiens 85-89 22034099-8 2012 In an analysis involving recombinant His-DDX3 and His-DDX5, PP2A pretreatment of His-DDX5 increased the interaction with endogenous DDX3, and vice versa. Histidine 50-53 DEAD-box helicase 5 Homo sapiens 54-58 22034099-8 2012 In an analysis involving recombinant His-DDX3 and His-DDX5, PP2A pretreatment of His-DDX5 increased the interaction with endogenous DDX3, and vice versa. Histidine 50-53 protein phosphatase 2 phosphatase activator Homo sapiens 60-64 22034099-8 2012 In an analysis involving recombinant His-DDX3 and His-DDX5, PP2A pretreatment of His-DDX5 increased the interaction with endogenous DDX3, and vice versa. Histidine 50-53 DEAD-box helicase 5 Homo sapiens 85-89 22170566-3 2012 Using the structure of a complex between the C-terminus of SNAP25 and BoNT/A-LC as a model to design SNAP25-derived pseudosubstrate inhibitors (SNAPIs) that prevent presentation of the scissile bond to the active site, we introduced multiple His residues to replace Ala-Asn-Gln-Arg (residues 195-198) at the substrate cleavage site, with the intent to identify possible side-chain interactions with the active site Zn. Histidine 242-245 synaptosome associated protein 25 Homo sapiens 59-65 22170566-3 2012 Using the structure of a complex between the C-terminus of SNAP25 and BoNT/A-LC as a model to design SNAP25-derived pseudosubstrate inhibitors (SNAPIs) that prevent presentation of the scissile bond to the active site, we introduced multiple His residues to replace Ala-Asn-Gln-Arg (residues 195-198) at the substrate cleavage site, with the intent to identify possible side-chain interactions with the active site Zn. Histidine 242-245 synaptosome associated protein 25 Homo sapiens 101-107 22590679-5 2012 However, when dialyzed together with Gst-gp3 or with Gst-gp4, His-gp2b and His-gp4 remain soluble and oligomers are obtained by affinity-chromatography. Histidine 62-65 CD36 molecule Homo sapiens 57-60 15196918-4 2004 In the CO-bound form of OxdA, the correlation between the Fe-CO stretching (512 cm(-1)) and C-O stretching (1950 cm(-1)) frequencies also supports our assignment of proximal histidine coordination. Histidine 174-183 D-amino acid oxidase Homo sapiens 24-28 15135404-3 2004 Recombinant SAP (r-SAP) was produced in a bioreactor with computer controlled fed-batch mode and purified by use of a C-terminal histidine tag. Histidine 129-138 amyloid P component, serum Homo sapiens 12-15 15135404-3 2004 Recombinant SAP (r-SAP) was produced in a bioreactor with computer controlled fed-batch mode and purified by use of a C-terminal histidine tag. Histidine 129-138 amyloid P component, serum Homo sapiens 19-22 15185439-2 2004 the mutations responsible are located in the CACNA1S gene (type 1) and in the SCN4A gene (type 2), and are all missense mutations where arginine is mostly replaced by histidine or sometimes glycine. Histidine 167-176 sodium voltage-gated channel alpha subunit 4 Homo sapiens 78-83 15109246-2 2004 The IDO(II)NO adduct, which is likely to play a physiological role in the immune system, differs from similar adducts such as Mb(II)NO and Lb(II)NO in that the Fe-His bond is essentially broken. Histidine 163-166 indoleamine 2,3-dioxygenase 1 Homo sapiens 4-7 15604682-9 2004 Both (His)6-ACBP4 and (His)6-ACBP5 bind [14C]oleoyl-CoA with high affinity, [14C]palmitoyl-CoA with lower affinity and did not bind [14C]arachidonyl-CoA. Histidine 6-9 acyl-CoA binding protein 4 Arabidopsis thaliana 12-17 14715082-3 2004 The present study describes the increased expression of both mRNA and protein for the cyclin-dependent kinase inhibitors p21 and p27 in response to deprivation of HepG2 cells for a single essential amino acid, histidine. Histidine 210-219 H3 histone pseudogene 16 Homo sapiens 121-124 14715082-3 2004 The present study describes the increased expression of both mRNA and protein for the cyclin-dependent kinase inhibitors p21 and p27 in response to deprivation of HepG2 cells for a single essential amino acid, histidine. Histidine 210-219 interferon alpha inducible protein 27 Homo sapiens 129-132 14715082-5 2004 For p21, increase in mRNA by histidine depletion appeared to be independent of p53 transactivation, and the absolute level of p53 protein was unaffected by this treatment. Histidine 29-38 H3 histone pseudogene 16 Homo sapiens 4-7 14715082-6 2004 Histidine limitation caused an increase in the phosphorylation of ERK1/ERK2 (extracellular-signal-regulated kinase), and inhibition of the ERK signal transduction pathway resulted in a reduction in the starvation-dependent increase in p21 mRNA. Histidine 0-9 H3 histone pseudogene 16 Homo sapiens 235-238 15034050-0 2004 Mutational analyses of the recombinant globular regions of human C1q A, B, and C chains suggest an essential role for arginine and histidine residues in the C1q-IgG interaction. Histidine 131-140 complement C1q A chain Homo sapiens 65-80 15034050-0 2004 Mutational analyses of the recombinant globular regions of human C1q A, B, and C chains suggest an essential role for arginine and histidine residues in the C1q-IgG interaction. Histidine 131-140 complement C1q A chain Homo sapiens 65-68 15034050-6 2004 Because C1q is a charge pattern recognition molecule, we have sequentially targeted arginine and histidine residues in each chain. Histidine 97-106 complement C1q A chain Homo sapiens 8-11 15034050-7 2004 Consistent with previous chemical modification studies and the recent crystal structure of gC1q, our results support a central role for arginine and histidine residues, especially Arg(114) and Arg(129) of the ghB module, in the C1q-IgG interaction. Histidine 149-158 complement C1q A chain Homo sapiens 92-95 14989719-4 2004 The sequence of B*5809 is identical to that of HLA-B*5801, except for a point mutation at position 583 in exon 3, where a T is substituted by a C. This change leads to an amino acidic substitution from Tyr (TAC) to His (CAC) at codon 171. Histidine 215-218 major histocompatibility complex, class I, B Homo sapiens 47-52 14725977-12 2004 These findings indicate that the elevation of histamine H(2) receptor stimulation by massive administration of histidine suppresses reperfusion injury in the brain. Histidine 111-120 histamine receptor H 2 Rattus norvegicus 46-69 14560312-5 2004 The exchanges of arginine to histidine, found in two unrelated patients with TRPS I, as well as the exchange of arginine to cysteine, found in another unrelated patient, prevent the translocation of the mutant TRPS1 to the nucleus when ectopically expressed in COS 7 cells. Histidine 29-38 transcriptional repressor GATA binding 1 Homo sapiens 210-215 14762077-12 2004 Based on evolution of extraction rate and ratio of uptake to output, His and Leu could have limited the milk protein yield response to glucose infusions. Histidine 69-72 PY Bos taurus 104-122 14705189-8 2004 Moreover, the utilization of histidine-immobilized agarose gel effectively concentrated the trace amount of LPS from the C(12)E(10)-solubilized HbV solution and washed out C(12)E(10) as an inhibitory element. Histidine 29-38 interferon regulatory factor 6 Homo sapiens 108-111 14763985-6 2004 Mutations in the conserved cysteine- and histidine-rich regions and ATPase and helicase motifs of Upf1p separate the ability of Upf1p to complement the respiratory impairment of a Deltaupf1 strain from its ability to act as a multicopy suppressor of mitochondrial splicing deficiency, indicating that distinct pathways express these phenotypes. Histidine 41-50 ATP-dependent RNA helicase NAM7 Saccharomyces cerevisiae S288C 128-133 14760716-5 2004 Here we present a simple procedure to isolate and separate proteins that contain redox active cysteines using a site-directed, histidine-tagged mutant of thioredoxin, which forms stable mixed disulphides with its targets. Histidine 127-136 thioredoxin Homo sapiens 154-165 22174408-4 2012 By contrast, the plasma membrane CeHRG-4 transports heme by utilizing a histidine in the exoplasmic (E2) loop and the FARKY motif. Histidine 72-81 Heme transporter hrg-4 Caenorhabditis elegans 33-40 22174408-6 2012 An analogous system exists in humans, because mutation of the synonymous histidine in TMD2 of hHRG-1 eliminates heme transport activity, implying an evolutionary conserved heme transport mechanism that predates vertebrate origins. Histidine 73-82 solute carrier family 48 member 1 Homo sapiens 94-100 21310790-7 2012 Moreover, mutation of a conserved histidine in the NACHT domain also has contrasting effects on NOD1 and NOD2 mediated NF-kappaB activation. Histidine 34-43 nucleotide binding oligomerization domain containing 1 Homo sapiens 96-100 22105071-8 2012 Simultaneous mutation of residues Cys-188, Cys-195, His-199, His-201, and His-202 in this domain significantly compromised MOV10 anti-HIV-1 activity. Histidine 52-55 Mov10 RISC complex RNA helicase Homo sapiens 123-128 22105071-8 2012 Simultaneous mutation of residues Cys-188, Cys-195, His-199, His-201, and His-202 in this domain significantly compromised MOV10 anti-HIV-1 activity. Histidine 61-64 Mov10 RISC complex RNA helicase Homo sapiens 123-128 22105071-8 2012 Simultaneous mutation of residues Cys-188, Cys-195, His-199, His-201, and His-202 in this domain significantly compromised MOV10 anti-HIV-1 activity. Histidine 61-64 Mov10 RISC complex RNA helicase Homo sapiens 123-128 22131323-3 2011 Divalent cations Zn(2+), Cu(2+) and Ni(2+) inhibit Ca(V)3.2 channels more efficiently than Ca(V)3.1 and Ca(V)3.3 channels via second high-affinity binding site including histidine H191 specific for the Ca(V)3.2 channel. Histidine 170-179 immunoglobulin lambda variable 7-43 Homo sapiens 51-59 22161108-7 2011 As Bmh and Amh contain anti-HI in sera, great attention should be paid to avoid adverse reaction of blood transfusion in clinics. Histidine 28-30 anti-Mullerian hormone Homo sapiens 11-14 22103913-8 2011 Histidine (His)-tagged PTEN fusion protein was generated in Sf9 baculovirus expression system. Histidine 0-9 phosphatase and tensin homolog Homo sapiens 23-27 22103913-8 2011 Histidine (His)-tagged PTEN fusion protein was generated in Sf9 baculovirus expression system. Histidine 0-3 phosphatase and tensin homolog Homo sapiens 23-27 22057958-5 2011 Sequence analysis showed that five binding sites of iron, including two consensus histidines in the LOX domain, are highly conserved in the cucumber LOX proteins. Histidine 83-93 linoleate 9S-lipoxygenase 6-like Cucumis sativus 101-104 22057958-5 2011 Sequence analysis showed that five binding sites of iron, including two consensus histidines in the LOX domain, are highly conserved in the cucumber LOX proteins. Histidine 83-93 linoleate 9S-lipoxygenase 6-like Cucumis sativus 151-154 21900231-6 2011 We also employed structure-based mutagenesis; the results support the importance of the alpha-amino methionine-specific pocket of Naa50p and are consistent with the proposal that conserved histidine and tyrosine residues play important catalytic roles. Histidine 189-198 N-alpha-acetyltransferase 50, NatE catalytic subunit Homo sapiens 130-136 21616146-3 2011 Here we used the yeast two-hybrid system to demonstrate that FGFRL1 binds with its C-terminal, histidine-rich domain to Spred1 and to other proteins of the Sprouty/Spred family. Histidine 95-104 sprouty related EVH1 domain containing 1 Homo sapiens 120-126 14556652-8 2004 One of the ligands to the catalytic metal, His(5), was altered to glutamine, a side chain found in the Zn(2+)-active Homo sapiens GlxI. Histidine 43-46 glyoxalase I Homo sapiens 130-134 15752073-5 2004 However, the best sequence alignment we could obtain suggests that while catalytic Ser is conserved across Clp and SDH proteinases the location of the other catalytic triad residues, namely, His and Asp are swapped in their amino acid alignment positions and hence in 3-D structure. Histidine 191-194 calmodulin like 3 Homo sapiens 107-110 15323354-2 2004 Analysis of known protein disulphide isomerase and thioredoxin sequences has revealed the presence of conserved Cys, His and Asp residues required for transglutaminases to catalyze the incorporation of primary amines into protein-bound glutamine residues. Histidine 117-120 thioredoxin Homo sapiens 51-62 15697091-1 2004 Hemoglobin Q-India is a very rare alpha-chain structural variant caused by the mutation AAG-->GAG (Asp-->His) in the position of codon 64 of the alpha1 gene. Histidine 111-114 adrenoceptor alpha 1D Homo sapiens 151-157 14659886-1 2003 Human zinc-fingers and homeoboxes (ZHX) 1, ZHX2 and ZHX3, members of the ZHX family, contain two Cys(2)-His(2)-type zinc-finger motifs and five homeodomains (HDs). Histidine 104-107 zinc fingers and homeoboxes 3 Mus musculus 52-56 14662886-4 2003 His-Phe-Tyr-Leu-Pro-Met (HFYLPM) is a synthetic peptide that binds to FPRL1. Histidine 0-3 formyl peptide receptor 2 Homo sapiens 70-75 13679373-7 2003 Pro-446, corresponding to the Pro/His mutation in dominant negative TLR4, is located in the third loop at the outmost edge of the TIR domain and does not play any structural role. Histidine 34-37 toll like receptor 4 Homo sapiens 68-72 12959987-7 2003 However, l-His potentiates cAMP response element reporter activity in INS-1 cells and in human embryonic kidney-293 cells expressing either the GLP-1R alone or the CaSR and GLP-1R. Histidine 9-14 insulin 1 Rattus norvegicus 70-75 21768284-3 2011 The pneumococcal genome encodes two conserved proteins of an as yet unknown function, SP1298 and SP2205, classified as DHH (Asp-His-His) subfamily 1 proteins. Histidine 128-131 desert hedgehog Mus musculus 119-122 21768284-3 2011 The pneumococcal genome encodes two conserved proteins of an as yet unknown function, SP1298 and SP2205, classified as DHH (Asp-His-His) subfamily 1 proteins. Histidine 132-135 desert hedgehog Mus musculus 119-122 21749116-7 2011 LC-MS/MS analyses of tryptic digests by identified His(450) and His(490) of Hsp90alpha as having a 158 Da modification, corresponding to NaBH(4)-reduced HNE adducts. Histidine 51-54 heat shock protein 90 alpha family class A member 1 Homo sapiens 76-86 14604533-4 2003 In vitro Sco1 binds copper(I) through a CXXXCP motif and possibly His 135 and copper(II) in two different species, thus suggesting that copper(II) is adventitious more than physiological. Histidine 66-69 Cu-binding protein SCO1 Saccharomyces cerevisiae S288C 9-13 12837132-8 2003 Taken together, the selectivity of Abz-HPGGPQ-EDN2ph to cathepsin K primarily depends on the S2 and S2" subsite specificities of cathepsin K and the ionization state of histidine at P3. Histidine 169-178 cathepsin K Homo sapiens 56-67 14529291-2 2003 Accordingly, we overexpressed human cPLA(2)gamma containing an N-terminal His tag ((His)(6)cPLA(2)gamma) in Sf9 cells and quantitatively solubilized and purified the enzyme by sequential immobilized metal affinity and Mono Q column chromatographies. Histidine 74-77 phospholipase A2 group IVC Homo sapiens 36-48 14529291-2 2003 Accordingly, we overexpressed human cPLA(2)gamma containing an N-terminal His tag ((His)(6)cPLA(2)gamma) in Sf9 cells and quantitatively solubilized and purified the enzyme by sequential immobilized metal affinity and Mono Q column chromatographies. Histidine 74-77 phospholipase A2 group IVC Homo sapiens 91-103 14519942-4 2003 Oral administration of histidine at 200 mg/kg once daily for 5 d before intravenous LPS injection increased the plasma alanine aminotransferase (ALT) activity to 2936.5+/-356.3 IU/l, a significant change compared with the controls (2244.8+/-425.5 IU/l, p<0.05). Histidine 23-32 glutamic pyruvic transaminase, soluble Mus musculus 145-148 21749116-7 2011 LC-MS/MS analyses of tryptic digests by identified His(450) and His(490) of Hsp90alpha as having a 158 Da modification, corresponding to NaBH(4)-reduced HNE adducts. Histidine 64-67 heat shock protein 90 alpha family class A member 1 Homo sapiens 76-86 21749116-8 2011 Five histidine residues were also adducted on Hsp90beta: His(171), His(442), His(458), His(625), and His(632). Histidine 5-14 heat shock protein 90 alpha family class B member 1 Homo sapiens 46-55 21749116-8 2011 Five histidine residues were also adducted on Hsp90beta: His(171), His(442), His(458), His(625), and His(632). Histidine 57-60 heat shock protein 90 alpha family class B member 1 Homo sapiens 46-55 21749116-8 2011 Five histidine residues were also adducted on Hsp90beta: His(171), His(442), His(458), His(625), and His(632). Histidine 67-70 heat shock protein 90 alpha family class B member 1 Homo sapiens 46-55 21749116-8 2011 Five histidine residues were also adducted on Hsp90beta: His(171), His(442), His(458), His(625), and His(632). Histidine 67-70 heat shock protein 90 alpha family class B member 1 Homo sapiens 46-55 21749116-8 2011 Five histidine residues were also adducted on Hsp90beta: His(171), His(442), His(458), His(625), and His(632). Histidine 67-70 heat shock protein 90 alpha family class B member 1 Homo sapiens 46-55 21749116-8 2011 Five histidine residues were also adducted on Hsp90beta: His(171), His(442), His(458), His(625), and His(632). Histidine 67-70 heat shock protein 90 alpha family class B member 1 Homo sapiens 46-55 21749116-11 2011 Within the middle client-binding domain of Hsp90alpha, residue His(450) demonstrated the most rapid adduction with k(obs) of 1.08 +- 0.17 h(-1) in HNE-treated cells. Histidine 63-66 heat shock protein 90 alpha family class A member 1 Homo sapiens 43-53 21749116-12 2011 The homologous residue on Hsp90beta, His(442), was adducted more rapidly than the N-terminal residue, His(171), despite very similar predicted pK(a) values of both residues. Histidine 37-40 heat shock protein 90 alpha family class B member 1 Homo sapiens 26-35 21680741-7 2011 These data indicated that His-396 is important for the formation of the C4a-hydroperoxy-FMN intermediate but is not involved in H(2)O(2) elimination. Histidine 26-29 complement C4A (Rodgers blood group) Homo sapiens 72-75 21659509-8 2011 Mutations of two alpha, two beta, and two gamma His residues within extracellular domains significantly reduced the inhibition of human ENaC by Cu(2+). Histidine 48-51 sodium channel, nonvoltage-gated 1 alpha Mus musculus 136-140 21680735-6 2011 Furthermore, exchange of His-88, mediating an intramolecular H(+)-shuttle in CAIV, to alanine resulted only in a slight decrease in CAIV-mediated augmentation of MCT2 activity. Histidine 25-28 carbonic anhydrase 4 gene 1 S homeolog Xenopus laevis 77-81 14518047-0 2003 Formation of S-[2-carboxy-1-(1H-imidazol-4-yl) ethyl]glutathione, a new metabolite of L-histidine, from cis-urocanic acid and glutathione by the action of glutathione S-transferase. Histidine 86-97 hematopoietic prostaglandin D synthase Rattus norvegicus 155-180 12917459-6 2003 Among three amino acid differences (positions 60, 61 and 63) in this region, histidine 61 present in human SLAM was most significant, but combined substitutions with this residue and one or both of isoleucine 60 and valine 63 increased further the receptor activity of mouse SLAM. Histidine 77-86 signaling lymphocytic activation molecule family member 1 Mus musculus 275-279 14578575-6 2003 The catalytic triad of serine proteinases of the subtilisin family was found at Asp-168, His-209, and Ser-383 in the PC1 protein and at Asp-167, His-208, and Ser-384 in the PC2 protein. Histidine 89-92 proprotein convertase subtilisin/kexin type 1 Homo sapiens 117-120 12914946-5 2003 However, the catalytic triad of Cys-His-Glu is not strictly conserved in DJ-1, implying that DJ-1 has a different catalytic mechanism if it acts as a protease or DJ-1 serves as a regulatory protein in the physiological processes. Histidine 36-39 Parkinsonism associated deglycase Homo sapiens 93-97 12914946-5 2003 However, the catalytic triad of Cys-His-Glu is not strictly conserved in DJ-1, implying that DJ-1 has a different catalytic mechanism if it acts as a protease or DJ-1 serves as a regulatory protein in the physiological processes. Histidine 36-39 Parkinsonism associated deglycase Homo sapiens 93-97 12766158-5 2003 Because it had been proposed that a histidine residue might be the proximal heme ligand in IDO, mutation to alanine of the three highly conserved histidines His16, His303, and His346 was conducted. Histidine 36-45 indoleamine 2,3-dioxygenase 1 Homo sapiens 91-94 12766158-5 2003 Because it had been proposed that a histidine residue might be the proximal heme ligand in IDO, mutation to alanine of the three highly conserved histidines His16, His303, and His346 was conducted. Histidine 146-156 indoleamine 2,3-dioxygenase 1 Homo sapiens 91-94 12865089-8 2003 These results imply that following repeated L-histidine administration in the rat (1) there is enhanced synthesis of brain histamine not reflected in its functional release; (2) the excess of histamine is sequestered and stored rather than being metabolized; (3) histamine H(3) receptor binding properties are not altered, whereas receptor density is changed in selected regions. Histidine 44-55 histamine receptor H3 Rattus norvegicus 263-286 21680735-6 2011 Furthermore, exchange of His-88, mediating an intramolecular H(+)-shuttle in CAIV, to alanine resulted only in a slight decrease in CAIV-mediated augmentation of MCT2 activity. Histidine 25-28 carbonic anhydrase 4 gene 1 S homeolog Xenopus laevis 132-136 20652826-7 2011 LPS treatment of HepG2 cells transiently expressing a histidine-tagged human cardiolipin synthase-1 (hCLS1) reduced hCLS1 mRNA and newly synthesized CLS activity indicating that LPS inhibits production of newly synthesized hCLS1 via reduction in hCLS1 mRNA. Histidine 54-63 cardiolipin synthase 1 Homo sapiens 77-99 20652826-7 2011 LPS treatment of HepG2 cells transiently expressing a histidine-tagged human cardiolipin synthase-1 (hCLS1) reduced hCLS1 mRNA and newly synthesized CLS activity indicating that LPS inhibits production of newly synthesized hCLS1 via reduction in hCLS1 mRNA. Histidine 54-63 cardiolipin synthase 1 Homo sapiens 101-106 20652826-7 2011 LPS treatment of HepG2 cells transiently expressing a histidine-tagged human cardiolipin synthase-1 (hCLS1) reduced hCLS1 mRNA and newly synthesized CLS activity indicating that LPS inhibits production of newly synthesized hCLS1 via reduction in hCLS1 mRNA. Histidine 54-63 cardiolipin synthase 1 Homo sapiens 116-121 20652826-7 2011 LPS treatment of HepG2 cells transiently expressing a histidine-tagged human cardiolipin synthase-1 (hCLS1) reduced hCLS1 mRNA and newly synthesized CLS activity indicating that LPS inhibits production of newly synthesized hCLS1 via reduction in hCLS1 mRNA. Histidine 54-63 cardiolipin synthase 1 Homo sapiens 102-105 20652826-7 2011 LPS treatment of HepG2 cells transiently expressing a histidine-tagged human cardiolipin synthase-1 (hCLS1) reduced hCLS1 mRNA and newly synthesized CLS activity indicating that LPS inhibits production of newly synthesized hCLS1 via reduction in hCLS1 mRNA. Histidine 54-63 cardiolipin synthase 1 Homo sapiens 116-121 20652826-7 2011 LPS treatment of HepG2 cells transiently expressing a histidine-tagged human cardiolipin synthase-1 (hCLS1) reduced hCLS1 mRNA and newly synthesized CLS activity indicating that LPS inhibits production of newly synthesized hCLS1 via reduction in hCLS1 mRNA. Histidine 54-63 cardiolipin synthase 1 Homo sapiens 116-121 21402045-5 2011 The presence of these vesicles in the reaction buffer enhanced the specific activity of the His-tagged PDK1 (full-length, and the truncated kinase domain) and the activity of the full-length His-tagged AKT1 and AKT2 when assayed in a cascade-type reaction. Histidine 92-95 pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial Cricetulus griseus 103-107 21565198-2 2011 Sequence analysis suggests that Rv2613c belongs to the histidine triad (HIT) motif superfamily, which includes HIT family diadenosine polyphosphate (Ap(n)A) hydrolases and Ap(4)A phosphorylases. Histidine 55-64 AP-4-A phosphorylase Mycobacterium tuberculosis H37Rv 32-39 12878219-2 2003 Structural and functional studies have shown that the NAT1 and factor XIII transglutaminase catalytic pockets are structurally related with the existence of a conserved catalytic triad (Cys-His-Asp). Histidine 190-193 N-acetyltransferase 1 Homo sapiens 54-58 12815280-5 2003 To test this hypothesis, the peptide zAsp(Ome)-Arg-His-Asp(Ome)-fluoromethyl ketone (zDRHDfmk) was synthesized. Histidine 51-54 LIM domain binding 3a Danio rerio 37-41 12815280-5 2003 To test this hypothesis, the peptide zAsp(Ome)-Arg-His-Asp(Ome)-fluoromethyl ketone (zDRHDfmk) was synthesized. Histidine 51-54 LIM domain binding 3a Danio rerio 38-41 21674702-2 2011 Two highly conserved histidines in the sixth transmembrane domain (TMD6) are essential for metal transport activity in DMT1. Histidine 21-31 solute carrier family 11 member 2 Homo sapiens 119-123 21674702-9 2011 The changes in conformation and intermolecular interaction induced by histidine substitution may be correlated with the deficiency of DMT1 in metal-ion permeation. Histidine 70-79 solute carrier family 11 member 2 Homo sapiens 134-138 21666675-2 2011 Most missense mutations in the OCRL ASH-RhoGAP domain that are found in affected individuals abolish interactions with the endocytic adaptors APPL1 and Ses (both Ses1 and Ses2), which bind OCRL through a short phenylalanine and histidine (F&H) motif. Histidine 228-237 OCRL inositol polyphosphate-5-phosphatase Homo sapiens 31-35 12740384-1 2003 Histidines 107 and 109 in the glycine receptor (GlyR) alpha1 subunit have previously been identified as determinants of the inhibitory zinc-binding site. Histidine 0-10 glycine receptor alpha 1 Homo sapiens 30-60 21666675-2 2011 Most missense mutations in the OCRL ASH-RhoGAP domain that are found in affected individuals abolish interactions with the endocytic adaptors APPL1 and Ses (both Ses1 and Ses2), which bind OCRL through a short phenylalanine and histidine (F&H) motif. Histidine 228-237 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 Homo sapiens 142-147 21666675-2 2011 Most missense mutations in the OCRL ASH-RhoGAP domain that are found in affected individuals abolish interactions with the endocytic adaptors APPL1 and Ses (both Ses1 and Ses2), which bind OCRL through a short phenylalanine and histidine (F&H) motif. Histidine 228-237 OCRL inositol polyphosphate-5-phosphatase Homo sapiens 189-193 21324097-2 2011 The substitution of arginine (R) for histidine (H) in the 131 position defines three allelic patterns, H/H, R/R, and H/R, resulting in FcgammaRIIA-H/H131 affinity for IgG2 and higher affinity for IgG3 subclasses. Histidine 37-46 immunoglobulin heavy constant gamma 3 (G3m marker) Homo sapiens 196-200 21563332-0 2004 (111)In-DOTA-4-amino-1-carboxymethyl-piperidine-D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2 The amphibian bombesin (BBN or BN, a peptide of 14 amino acids) is an analog of human gastrin-releasing peptide (GRP, a peptide of 27 amino acids) that binds to GRP receptor (GRPR) with high affinity and specificity (1). Histidine 74-77 GCY Homo sapiens 78-81 21563332-12 2004 A DOTA-Gly-benzoyl group was added to the C-terminus to form DOTA-Gly-benzoyl-d-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2 (RM1). Histidine 104-107 GCY Homo sapiens 108-111 21443971-6 2011 In both cases, His-tHBP-HA shows similar apparent K(m) and apparent V(max) values. Histidine 15-18 trans-o-hydroxybenzylidenepyruvate hydratase-aldolase Pseudomonas fluorescens 19-26 12672824-1 2003 Human, microsomal, and glutathione-dependent prostaglandin (PG) E synthase-1 (mPGES-1) was expressed with a histidine tag in Escherichia coli. Histidine 108-117 prostaglandin E synthase Mus musculus 78-85 12808042-10 2003 Instead, a conserved histidine (H434) present within a hydrophobic peptide segment, may be essential for ACAT catalysis. Histidine 21-30 sterol O-acyltransferase 1 Cricetulus griseus 105-109 12748294-1 2003 The histidine triad (HIT) protein Hint has been found to associate with mammalian Cdk7, as well as to interact both physically and genetically with the budding yeast Cdk7 homologue Kin28. Histidine 4-13 cyclin-dependent kinase 7 Mus musculus 166-170 12748294-1 2003 The histidine triad (HIT) protein Hint has been found to associate with mammalian Cdk7, as well as to interact both physically and genetically with the budding yeast Cdk7 homologue Kin28. Histidine 4-13 TFIIH complex serine/threonine-protein kinase subunit KIN28 Saccharomyces cerevisiae S288C 181-186 12856592-4 2003 Western blot analysis with specific anti-histidines antibody revealed that the lysate of COS-7 cells transfected by rpcDNA3.1/Myc-His/hBD-2 had a strong band with molecular weight of about 10 Kd that was approximate to the size of chiasmic peptide. Histidine 41-51 MYC proto-oncogene, bHLH transcription factor Homo sapiens 126-129 21443971-7 2011 Further analyses showed that the optimal pH and temperature of His-tHBP-HA activity are 7.0 and 30 C, respectively. Histidine 63-66 trans-o-hydroxybenzylidenepyruvate hydratase-aldolase Pseudomonas fluorescens 67-74 20623307-0 2011 Molecular modeling and dynamics simulation of a histidine-tagged cytochrome b5. Histidine 48-57 cytochrome b5 type A Homo sapiens 65-78 12522007-0 2003 Iron transport by Nramp2/DMT1: pH regulation of transport by 2 histidines in transmembrane domain 6. Histidine 63-73 solute carrier family 11 member 2 Homo sapiens 18-24 12522007-0 2003 Iron transport by Nramp2/DMT1: pH regulation of transport by 2 histidines in transmembrane domain 6. Histidine 63-73 solute carrier family 11 member 2 Homo sapiens 25-29 12711688-4 2003 The AtTFIIIA cDNA encodes a protein with nine Cys(2)-His(2)-type zinc fingers, a 23 amino acid spacer between fingers 1 and 2, a 66 amino acid spacer between fingers 4 and 5, and a 50 amino acid non-finger C-terminal tail. Histidine 53-56 transcription factor IIIA Arabidopsis thaliana 4-12 12578831-2 2003 Exposure of this histidine in antithrombin, which has a partially opened sheet, allows polymerization and peptide insertion to occur at pH 6 or less when His-334 will be predictably protonated with disruption of the H-bond network. Histidine 17-26 serpin family C member 1 Homo sapiens 30-42 12578831-2 2003 Exposure of this histidine in antithrombin, which has a partially opened sheet, allows polymerization and peptide insertion to occur at pH 6 or less when His-334 will be predictably protonated with disruption of the H-bond network. Histidine 154-157 serpin family C member 1 Homo sapiens 30-42 12578831-3 2003 Similarly, thermal stability of antithrombin is pH-dependent with a single unfolding transition at pH 6, but there is no such transition when His-334 is buried by a fully closed A-sheet in heparin-complexed antithrombin or in alpha(1)-antitrypsin. Histidine 142-145 serpin family C member 1 Homo sapiens 32-44 12578831-4 2003 Replacement of His-334 in alpha(1)-antitrypsin by a serine or alanine at pH 7.4 results in the same polymerization and loop-peptide acceptance observed with antithrombin at low pH. Histidine 15-18 serpin family C member 1 Homo sapiens 157-169 12926399-3 2003 Barrels with internal arginine-histidine dyads form cation selective (PK/Pc1 = 2.1), small and ohmic ion channels with superb stability (single-channel lifetime > 20 seconds). Histidine 31-40 polycystin 1, transient receptor potential channel interacting Homo sapiens 73-76 12650998-0 2003 Mutation of surface-exposed histidine residues of recombinant human granulocyte-colony stimulating factor (Cys17Ser) impacts on interaction with chelated metal ions and refolding in aqueous two-phase systems. Histidine 28-37 colony stimulating factor 3 Homo sapiens 68-105 21375246-0 2011 Model peptides provide new insights into the role of histidine residues as potential ligands in human cellular copper acquisition via Ctr1. Histidine 53-62 solute carrier family 31 member 1 Homo sapiens 134-138 21375246-3 2011 Unlike yeast, mammalian Ctr1 also contains extracellular histidine-rich motifs, although a role for these regions in copper uptake has not been explored in detail. Histidine 57-66 solute carrier family 31 member 1 Homo sapiens 24-28 21375246-6 2011 These model studies suggest that the histidine domains may play a direct role in copper acquisition from serum copper-binding proteins and in facilitating the reduction of Cu(II) to the active Ctr1 substrate, Cu(I). Histidine 37-46 solute carrier family 31 member 1 Homo sapiens 193-197 21375246-8 2011 Results from live cell studies support the hypothesis that extracellular amino-terminal His residues directly participate in the copper transport function of Ctr1. Histidine 88-91 solute carrier family 31 member 1 Homo sapiens 158-162 21324305-10 2011 One possible candidate could be the histidine-rich C-terminal domain of PCSK9. Histidine 36-45 proprotein convertase subtilisin/kexin type 9 Homo sapiens 72-77 21167151-5 2011 The intake of histidine or carnosine significantly diminished the activity and mRNA expression of malic enzyme, FAS, HMG-CoA reductase, SREBP-1c and SREBP-2, which led to lower body weight, epididymal fat, and hepatic triglyceride and cholesterol levels (P<0.05). Histidine 14-23 sterol regulatory element binding transcription factor 1 Mus musculus 136-144 21117662-5 2011 There is also a contribution from the C-terminus in conjunction with the histidine at position 50 in alpha-synuclein and position 65 in beta-synuclein, although these regions appear to have little effect on overall coordination stability. Histidine 73-82 synuclein alpha Homo sapiens 101-116 21628886-5 2011 Twelve metabolites in mesencephalon of S100B transgenic mice were identified as potential biomarkers, among which, glutamic acid (Glu) detected by RP/MS in negative ionization mode, gamma-aminobutyric acid (GABA) and tryptophan (Trp) detected by HILIC/MS in positive ionization mode, phenylalanine (Phe) and histidine (His) detected by HILIC/MS in negative ionization mode, related to metabolic pathway of neurotransmitters in mice central nervous system. Histidine 308-317 S100 protein, beta polypeptide, neural Mus musculus 39-44 21628886-5 2011 Twelve metabolites in mesencephalon of S100B transgenic mice were identified as potential biomarkers, among which, glutamic acid (Glu) detected by RP/MS in negative ionization mode, gamma-aminobutyric acid (GABA) and tryptophan (Trp) detected by HILIC/MS in positive ionization mode, phenylalanine (Phe) and histidine (His) detected by HILIC/MS in negative ionization mode, related to metabolic pathway of neurotransmitters in mice central nervous system. Histidine 319-322 S100 protein, beta polypeptide, neural Mus musculus 39-44 20533040-1 2011 His(354) and His(358), two highly conserved histidines in Xenopus laevis (6-4) photolyase [equivalent to His(401) and His(405), in Dunaliella salina (6-4) photolyase], are critical for photoreactivation. Histidine 0-3 6-4 photolyase Xenopus laevis 74-89 20533040-1 2011 His(354) and His(358), two highly conserved histidines in Xenopus laevis (6-4) photolyase [equivalent to His(401) and His(405), in Dunaliella salina (6-4) photolyase], are critical for photoreactivation. Histidine 0-3 6-4 photolyase Xenopus laevis 150-165 20533040-1 2011 His(354) and His(358), two highly conserved histidines in Xenopus laevis (6-4) photolyase [equivalent to His(401) and His(405), in Dunaliella salina (6-4) photolyase], are critical for photoreactivation. Histidine 13-16 6-4 photolyase Xenopus laevis 74-89 20533040-1 2011 His(354) and His(358), two highly conserved histidines in Xenopus laevis (6-4) photolyase [equivalent to His(401) and His(405), in Dunaliella salina (6-4) photolyase], are critical for photoreactivation. Histidine 44-54 6-4 photolyase Xenopus laevis 74-89 20533040-1 2011 His(354) and His(358), two highly conserved histidines in Xenopus laevis (6-4) photolyase [equivalent to His(401) and His(405), in Dunaliella salina (6-4) photolyase], are critical for photoreactivation. Histidine 13-16 6-4 photolyase Xenopus laevis 74-89 20533040-1 2011 His(354) and His(358), two highly conserved histidines in Xenopus laevis (6-4) photolyase [equivalent to His(401) and His(405), in Dunaliella salina (6-4) photolyase], are critical for photoreactivation. Histidine 13-16 6-4 photolyase Xenopus laevis 74-89 21734345-7 2011 Analysis of combinations showed a significant association of 113His/His EPHX1/null-GSTM1 (OR=4.07) and null-GSTM1/105Val/Val GSTP1 (OR =3.56) genotypes with increased risk of COPD (respectively P=0.0094 and P=0.0153). Histidine 64-67 epoxide hydrolase 1 Homo sapiens 72-77 21179510-5 2010 We also discovered that the central proline-rich and histidine-rich domain of HD-PTP is responsible for these interactions. Histidine 53-62 protein tyrosine phosphatase non-receptor type 23 Homo sapiens 78-84 12616630-5 2003 The NMR structure of the SUPERMAN zinc finger domain consists of a very well-defined betabetaalpha motif, typical of all other Cys(2)-His(2) zinc fingers structurally characterized. Histidine 134-137 C2H2 and C2HC zinc fingers superfamily protein Arabidopsis thaliana 25-33 12675566-3 2003 The highest G6PDH production (1164 U/L) and specific activity (517 U/g(cell)) were obtained using the following conditions: glucose, 5.0 g/L; adenine, 8 microg/mL; histidine, 8 microg/mL; tryptophan, 8 microg/mL; temperature, 30 degrees C; inoculum, 1.28 g/L; pH, 5.7; agitation, 400 rpm; aeration, 2.2 vvm; and K, 0.2 h(-)(1). Histidine 164-173 glucose-6-phosphate dehydrogenase Saccharomyces cerevisiae S288C 12-17 20828147-12 2010 Finally, we show that the mutant of His alpha-syn with all five proline residues mutated to alanine is more structured (more alpha-helix) than His-WT alpha-syn, indicating the role of the Pro residues as potential helix breakers in the inhibitory conformation of the C-terminus. Histidine 36-39 synuclein alpha Homo sapiens 40-49 20828147-12 2010 Finally, we show that the mutant of His alpha-syn with all five proline residues mutated to alanine is more structured (more alpha-helix) than His-WT alpha-syn, indicating the role of the Pro residues as potential helix breakers in the inhibitory conformation of the C-terminus. Histidine 36-39 synuclein alpha Homo sapiens 150-159 20978114-4 2010 Here, we uncover an MLH1 clinical mutation with a leucine (L)-to-histidine (H) amino acid change at position 607 that ablates MLH1 binding to FANCJ. Histidine 65-74 mutL homolog 1 Homo sapiens 20-24 12594264-4 2003 We investigated the potential of recombinant, His-tagged p19 lacking the secretion/acylation signal to induce macrophage apoptosis. Histidine 46-49 interleukin 23 subunit alpha Homo sapiens 57-60 12493732-5 2003 To gain mechanistic insight, we measured the effects of Saccharomyces cerevisiae Ssa1p (Hsp70) and Ydj1p (Hsp40) on the translocation of histidine-tagged prepro-alpha-factor (ppalphaF6H) into microsomes. Histidine 137-146 Hsp70 family ATPase SSA1 Saccharomyces cerevisiae S288C 81-86 12458209-4 2003 The validity of using the crystal structure of UvrB as a template for the development of an XPD model was tested by mimicking human disease-causing mutations (XPD: R112H, D234N, R601L) in UvrB (E110R, D338N, R506A) and by mutating two highly conserved residues (XPD, His-237 and Asp-609; UvrB, H341A and D510A). Histidine 267-270 ERCC excision repair 2, TFIIH core complex helicase subunit Homo sapiens 92-95 12446736-2 2003 Like the other ZnT proteins, the protein (387 amino acids) predicted from this gene contains six transmembrane domains and a histidine-rich loop between transmembrane domains IV and V. We show that Znt7 is widely transcribed in mouse tissues with abundant expression in the liver and small intestine and moderate expression in the kidney, spleen, brain, and lung. Histidine 125-134 solute carrier family 30 (zinc transporter), member 7 Mus musculus 198-202 12536071-6 2003 Additional mammalian proteins of interest to signal transduction and cancer research exhibit histidine phosphorylation, including P-selectin, annexin I and the 20S proteasome. Histidine 93-102 selectin P Homo sapiens 130-140 12669234-8 2003 The poly-clonal antibody raised against histidine-tagged fusion PTEN protein showed specific immuno-reactivity to PTEN protein. Histidine 40-49 phosphatase and tensin homolog Homo sapiens 64-68 12669234-8 2003 The poly-clonal antibody raised against histidine-tagged fusion PTEN protein showed specific immuno-reactivity to PTEN protein. Histidine 40-49 phosphatase and tensin homolog Homo sapiens 114-118 12610214-0 2003 In vivo and in vitro characterization of the ARR11 response regulator implicated in the His-to-Asp phosphorelay signal transduction in Arabidopsis thaliana. Histidine 88-91 response regulator 11 Arabidopsis thaliana 45-50 12610214-6 2003 In vitro, ARR11 showed the ability to acquire a phosphoryl group from a histidine-containing phosphotransfer intermediate (AHP), and also it showed the ability to recognize a specific nucleotide sequence, GGATT. Histidine 72-81 response regulator 11 Arabidopsis thaliana 10-15 20978114-4 2010 Here, we uncover an MLH1 clinical mutation with a leucine (L)-to-histidine (H) amino acid change at position 607 that ablates MLH1 binding to FANCJ. Histidine 65-74 mutL homolog 1 Homo sapiens 126-130 20978114-4 2010 Here, we uncover an MLH1 clinical mutation with a leucine (L)-to-histidine (H) amino acid change at position 607 that ablates MLH1 binding to FANCJ. Histidine 65-74 BRCA1 interacting helicase 1 Homo sapiens 142-147 20594158-2 2010 However, GLP-1 is rapidly degraded to GLP-1(9-36) by dipeptidyl peptidase-IV (DPP-IV), which removes the N-terminal dipeptide His(7)-Ala(8). Histidine 126-129 dipeptidylpeptidase 4 Mus musculus 53-76 20594158-2 2010 However, GLP-1 is rapidly degraded to GLP-1(9-36) by dipeptidyl peptidase-IV (DPP-IV), which removes the N-terminal dipeptide His(7)-Ala(8). Histidine 126-129 dipeptidylpeptidase 4 Mus musculus 78-84 20805576-13 2010 Several mutations of a histidine residue (H497) that is homologous to a histidine that is responsible for H(+) block in ClC-2 did not yield functional channels. Histidine 23-32 chloride voltage-gated channel 2 Homo sapiens 120-125 20805576-13 2010 Several mutations of a histidine residue (H497) that is homologous to a histidine that is responsible for H(+) block in ClC-2 did not yield functional channels. Histidine 72-81 chloride voltage-gated channel 2 Homo sapiens 120-125 20720509-8 2010 Increased AQP4 andalpha-syntrophin levels were inhibited by L-histidine, an inhibitor of glutamine transport into mitochondria, suggesting a role for glutamine in the increase of PM levels of AQP4. Histidine 60-71 aquaporin 4 Rattus norvegicus 10-14 12605682-8 2003 The existence of activity when the catalytic histidine is protonated indicates that the catalytic-triad mechanism of butyrylcholinesterase does not operate for catalysis at low pH. Histidine 45-54 butyrylcholinesterase Homo sapiens 117-138 20720509-8 2010 Increased AQP4 andalpha-syntrophin levels were inhibited by L-histidine, an inhibitor of glutamine transport into mitochondria, suggesting a role for glutamine in the increase of PM levels of AQP4. Histidine 60-71 aquaporin 4 Rattus norvegicus 192-196 20361220-3 2010 Previous studies suggested that the first step of the dioxygenase reaction involves the deprotonation of the indoleamine group of the substrate by an evolutionarily conserved distal histidine residue in TDO and the heme-bound dioxygen in IDO. Histidine 182-191 indoleamine 2,3-dioxygenase 1 Homo sapiens 238-241 20302943-5 2010 Both soluble renalase forms have been purified to homogeneity exploiting their N-terminal His-tag. Histidine 90-93 renalase, FAD dependent amine oxidase Homo sapiens 13-21 20460111-7 2010 In this study we show, that denuded IQ2 favours a closed conformation of myosin with a low HIS-MLC-1 binding affinity. Histidine 91-94 myosin heavy chain 14 Homo sapiens 73-79 20439756-2 2010 The crystal structure of apo UCHL1 showed that the active-site residues are not aligned in a canonical form, with the nucleophilic cysteine being 7.7 A from the general base histidine, an arrangement consistent with an inactive form of the enzyme. Histidine 174-183 ubiquitin C-terminal hydrolase L1 Homo sapiens 29-34 12867744-4 2003 These organisms also possess (1) HPr, the substrate for HprK/P; (2) enzyme I, which phosphorylates HPr at His-15, and (3) one or several enzymes IIA, which receive the phosphoryl group from P approximately His-HPr. Histidine 106-109 colicin Ia immunity protein Escherichia coli 145-148 20360762-3 2010 We describe procedures (i) for obtaining genetically modified sensors that are fully functional and suitable for AFM analysis, i.e., elongated Wsc1 derivatives terminated with a His-tag, and (ii) for detecting and stretching single Wsc1 sensors on the surface of living S. cerevisiae cells, using AFM tips functionalized with Ni(2+)-NTA groups. Histidine 178-181 Slg1p Saccharomyces cerevisiae S288C 232-236 20368108-6 2010 Firstly RT-PCR and Western blot results showed that the expression of TAP in GES-1 cells was increased after pcDNA3.1/V5-His-TAP1 transfection. Histidine 121-124 filamin B Homo sapiens 70-73 20371992-8 2010 Zn(II) binds to the N(tau) atom of histidine and the peptide aggregates through intermolecular His-Zn-His bridges. Histidine 35-44 microtubule associated protein tau Homo sapiens 22-25 20371992-8 2010 Zn(II) binds to the N(tau) atom of histidine and the peptide aggregates through intermolecular His-Zn-His bridges. Histidine 95-98 microtubule associated protein tau Homo sapiens 22-25 20371992-8 2010 Zn(II) binds to the N(tau) atom of histidine and the peptide aggregates through intermolecular His-Zn-His bridges. Histidine 102-105 microtubule associated protein tau Homo sapiens 22-25 20133602-6 2010 These findings define a consensus motif (which we have called a phenylalanine and histidine [F&H] motif) for OCRL binding and are consistent with a scenario in which Lowe syndrome and Dent disease result from perturbations at multiple sites within the endocytic pathway. Histidine 82-91 OCRL inositol polyphosphate-5-phosphatase Homo sapiens 113-117 12493540-4 2003 Human LAT1-mediated [(125)I]IMT uptake was highly stereoselective for the L-isomers of Tyr, His, Trp, Val and Ileu. Histidine 92-95 solute carrier family 7 member 5 Homo sapiens 6-10 12509991-9 2003 Six His residues at the C terminus of human TyrRS have little effect on the activities of the enzyme compared with other eukaryotic TyrRSs. Histidine 4-7 tyrosyl-tRNA synthetase 1 Homo sapiens 44-49 20099820-0 2010 Binding of histidine in the (Cys)3(His)1-coordinated [2Fe-2S] cluster of human mitoNEET. Histidine 11-20 CDGSH iron sulfur domain 1 Homo sapiens 79-87 20099820-6 2010 Simulation and least-squares fitting of orientation-selective Ka- and Q-band ENDOR, 1D ESEEM, and HYSCORE spectra of (14)N and (15)N-labeled mitoNEET yield the principal values and orientations of both the hyperfine tensor ((14)N, A(iso) = -6.25 MHz, T = -0.94 MHz) and the quadrupolar tensor (e(2)Qq/h = -2.47 MHz, eta = 0.38) of the ligating histidine nitrogen N(delta). Histidine 344-353 CDGSH iron sulfur domain 1 Homo sapiens 141-149 19925783-5 2010 Reversible binding of CYP2C9 via an engineered His tag to a phospholipid bilayer was facilitated using nickel-chelating lipids, presenting potential applications for biosensor technologies. Histidine 47-50 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 22-28 12459164-1 2002 Feline granulocyte colony-stimulating factor (G-CSF) with an N-terminal histidine hexamer tag was expressed as inclusion bodies in E. coli. Histidine 72-81 colony stimulating factor 3 Felis catus 46-51 19940152-3 2010 A histidine at position 191 was recently identified as a critical determinant for both trace metal block of Ca(v)3.2 and modulation by redox agents. Histidine 2-11 immunoglobulin lambda variable 7-43 Homo sapiens 108-116 19940152-5 2010 Mutation of the corresponding residue in Ca(v)3.1 to histidine, Gln(172), significantly enhances trace metal inhibition, but not to the level observed in wild-type Ca(v)3.2, implying that other residues also contribute to the metal binding site. Histidine 53-62 immunoglobulin lambda variable 7-43 Homo sapiens 164-172 19940144-9 2010 A conserved histidine in mammalian alpha1(III) at A1 may have prevented 3-hydroxylation because this site in chicken type III was fully hydroxylated, and tyrosine replaced histidine. Histidine 12-21 adrenoceptor alpha 1D Homo sapiens 35-52 12270930-4 2002 Experiments with substitution mutants showed that tyrosine 571, histidine 572, and their flanking leucine and isoleucine amino acids, which are all highly conserved in many fas-1 domains, are essential for mediating MRC-5 cell adhesion. Histidine 64-73 Fas cell surface death receptor Homo sapiens 173-178 12213808-8 2002 Finally, AMPD1 and a series of N-truncated AMPD3 enzymes are used to show that these behaviors are specific to isoform E and require up to 48 N-terminal amino acids, even though this stretch of sequence contains no histidine residues. Histidine 215-224 adenosine monophosphate deaminase 1 Homo sapiens 9-14 12194980-7 2002 Studies with recombinant V5-His-tagged FLRG protein confirm a direct interaction between mature myostatin and FLRG. Histidine 28-31 myostatin Mus musculus 96-105 12459266-5 2002 The presence of this motif, together with a conserved order and spacing of the Ser, Asp, and His residues that form the catalytic triad in DPP IV, places DPP9 in the "DPP IV gene family". Histidine 93-96 dipeptidyl peptidase 4 Homo sapiens 139-145 12459266-5 2002 The presence of this motif, together with a conserved order and spacing of the Ser, Asp, and His residues that form the catalytic triad in DPP IV, places DPP9 in the "DPP IV gene family". Histidine 93-96 dipeptidyl peptidase 4 Homo sapiens 167-173 12145299-3 2002 Pho2 + Swi5 activates HO, Pho2 + Pho4 activates PHO5, and Pho2 + Bas1 activates genes in the purine and histidine biosynthesis pathways. Histidine 104-113 Pho2p Saccharomyces cerevisiae S288C 0-4 12145299-3 2002 Pho2 + Swi5 activates HO, Pho2 + Pho4 activates PHO5, and Pho2 + Bas1 activates genes in the purine and histidine biosynthesis pathways. Histidine 104-113 Pho2p Saccharomyces cerevisiae S288C 26-30 12145299-3 2002 Pho2 + Swi5 activates HO, Pho2 + Pho4 activates PHO5, and Pho2 + Bas1 activates genes in the purine and histidine biosynthesis pathways. Histidine 104-113 Pho2p Saccharomyces cerevisiae S288C 26-30 12241546-4 2002 An anti-cathepsin L monoclonal antibody (mAb), named 3D8, was isolated from mice immunized with purified procathepsin L-His. Histidine 118-123 cathepsin L Mus musculus 8-19 19940144-9 2010 A conserved histidine in mammalian alpha1(III) at A1 may have prevented 3-hydroxylation because this site in chicken type III was fully hydroxylated, and tyrosine replaced histidine. Histidine 172-181 adrenoceptor alpha 1D Homo sapiens 35-52 19906646-7 2010 This property is likely caused by histidine residues in the vicinity of the mapped heparin binding site and could be important for the proposed adhesive function of APL-1. Histidine 34-43 acireductone dioxygenase 1 Homo sapiens 165-170 20057140-6 2010 The C-terminal catalytic segment of the human Frk kinase conjugating hexahistidine purification tag (His-tag) was expressed in Escherichia coli. Histidine 101-104 fyn related Src family tyrosine kinase Homo sapiens 46-49 19801377-5 2010 Palmitoyl acyltransferases DHHC5, DHHC6, and DHHC8 appear to be S-acylated on three cysteine residues within a novel CCX(7-13)C(S/T) motif downstream of a conserved Asp-His-His-Cys cysteine-rich domain, which may be a potential mechanism for regulating acyltransferase specificity and/or activity. Histidine 169-172 zinc finger DHHC-type palmitoyltransferase 8 Homo sapiens 45-50 19778616-2 2010 The amino acid sequence of Rv2613c contained a histidine triad (HIT) motif consisting of H-phi-H-phi-H-phi-phi, where phi is a hydrophobic amino acid. Histidine 47-56 AP-4-A phosphorylase Mycobacterium tuberculosis H37Rv 27-34 12107175-10 2002 Alanine-scanning mutagenesis of residues 105-117 within glutathione S-transferase (GST)-AbetaPP-(18-119) revealed that His(110), Val(112), and Ile(113) are key residues that facilitate AbetaPP binding to fibrillar Abeta. Histidine 119-122 glutathione S-transferase kappa 1 Homo sapiens 56-81 12107175-10 2002 Alanine-scanning mutagenesis of residues 105-117 within glutathione S-transferase (GST)-AbetaPP-(18-119) revealed that His(110), Val(112), and Ile(113) are key residues that facilitate AbetaPP binding to fibrillar Abeta. Histidine 119-122 glutathione S-transferase kappa 1 Homo sapiens 83-86 19481969-3 2010 The imidazole ring of histidine captures the Cd ions from the solution, and prevents the growth of the CdS nanoparticles. Histidine 22-31 CDP-diacylglycerol synthase 1 Homo sapiens 103-106 19481969-5 2010 CdS nanoparticles synthesized using histidine as organic chelating agent have band edge emission at approximately 481 nm and have greater photoluminescence intensity with blue-shift to higher energy due to typical quantum confinement effect. Histidine 36-45 CDP-diacylglycerol synthase 1 Homo sapiens 0-3 19860422-6 2009 Electron transfer to protonated HAL and AHL triggers an exothermic and dynamically barrierless transfer of the carboxyl proton onto the C-2" position of the His ring that occurs on a 120-240 ns time scale. Histidine 157-160 complement C2 Homo sapiens 136-139 19860422-11 2009 These radicals undergo proton migrations to the His ring C-5" positions that have moderate energy barriers and are less efficient. Histidine 48-51 complement C5 Homo sapiens 57-60 19791753-2 2009 MitoNEET also binds a unique three-Cys- and one-His-ligated [corrected] [2Fe-2S] cluster. Histidine 48-51 CDGSH iron sulfur domain 1 Homo sapiens 0-8 12045193-7 2002 The crystal structure of S100A3 allows the prediction of one putative Zn(2+) binding site in the C terminus of each subunit of S100A3 involving Cys and His residues in the coordination of the metal ion. Histidine 152-155 S100 calcium binding protein A3 Homo sapiens 25-31 12045193-7 2002 The crystal structure of S100A3 allows the prediction of one putative Zn(2+) binding site in the C terminus of each subunit of S100A3 involving Cys and His residues in the coordination of the metal ion. Histidine 152-155 S100 calcium binding protein A3 Homo sapiens 127-133 12234472-0 2002 Detection of polymorphisms at exons 3 (Tyr113-->His) and 4 (His139-->Arg) of the microsomal epoxide hydrolase gene using fluorescence PCR method combined with melting curves analysis. Histidine 51-54 epoxide hydrolase 1 Homo sapiens 87-115 19783046-9 2009 Domains I and II, in particular a histidine residue within Ca(V)3.2 (H191), are responsible for the subtype-prevalent N(2)O inhibition. Histidine 34-43 immunoglobulin lambda variable 7-43 Homo sapiens 59-67 19777055-14 2009 For the first time, to our knowledge, we demonstrate that changing the histidine residue in the conserved CPHGRP motif abolishes endonucleolytic activity of a hPMS2 homologue. Histidine 71-80 PMS1 homolog 2, mismatch repair system component Homo sapiens 159-164 19707690-2 2009 Here we highlight a crucial role of a basic amino acid triad the entrance of the heme pocket in rHSA (Arg-114, His-146, Lys-190) for O(2) and CO binding to the prosthetic Fe(2+)PP group. Histidine 111-114 CD24 molecule Rattus norvegicus 96-100 19553567-2 2009 Homology models constructed on the basis of the experimental structures of Escherichia coli AmtB and Nitrosomonas europaea Rh50 indicated a channel structure for human RhA (RhAG), RhB (RhBG), and RhC (RhCG) glycoproteins in which external and internal vestibules are linked by a pore containing two strictly conserved histidines. Histidine 318-328 Rh associated glycoprotein Homo sapiens 168-171 19553567-2 2009 Homology models constructed on the basis of the experimental structures of Escherichia coli AmtB and Nitrosomonas europaea Rh50 indicated a channel structure for human RhA (RhAG), RhB (RhBG), and RhC (RhCG) glycoproteins in which external and internal vestibules are linked by a pore containing two strictly conserved histidines. Histidine 318-328 Rh associated glycoprotein Homo sapiens 173-177 19535453-5 2009 In the CD4-bound conformation, the highly conserved histidine 66 is located between the receptor-binding and gp41-interactive surfaces of gp120. Histidine 52-61 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 138-143 19580301-5 2009 Calculation of the complete series of alkaline earth/histidine complexes confirms the increasing stability of the SB conformations relative to CS with increasing metal ion size, as well as showing that among SB conformations the most highly chelated conformation (SB3) is favored for small metals, whereas the most extended conformation (SB1) is favored for large metals. Histidine 53-62 SH3KBP1 binding protein 1 Homo sapiens 338-341 12385583-10 2002 In the present study, mutation of the p53 gene was detected in three DMBA-induced leukemias as follows: a single-base substitution (CAT to CGT) at codon 177 (exon 5), resulting in an amino-acid change from Arg to Leu, a CGG to CTG/CGG changed at codon 211 (exon 6) resulting in an amino-acid change from His to Arg/His, and a GGG to TGG at codon 242 (exon 6) resulting in an amino-acid change from Gly to Trp, respectively. Histidine 304-307 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 38-41 12385583-10 2002 In the present study, mutation of the p53 gene was detected in three DMBA-induced leukemias as follows: a single-base substitution (CAT to CGT) at codon 177 (exon 5), resulting in an amino-acid change from Arg to Leu, a CGG to CTG/CGG changed at codon 211 (exon 6) resulting in an amino-acid change from His to Arg/His, and a GGG to TGG at codon 242 (exon 6) resulting in an amino-acid change from Gly to Trp, respectively. Histidine 315-318 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 38-41 12161265-2 2002 Binding of [His(1), (125)I-Tyr(10), Nle(27)]hGHRH(1-32) amide and GHRH receptor (GHRH-R) mRNA levels were determined in the hypothalamus and pituitary of rats subjected to 8 h of SD and of undisturbed control rats. Histidine 12-15 growth hormone releasing hormone receptor Rattus norvegicus 66-79 12161265-2 2002 Binding of [His(1), (125)I-Tyr(10), Nle(27)]hGHRH(1-32) amide and GHRH receptor (GHRH-R) mRNA levels were determined in the hypothalamus and pituitary of rats subjected to 8 h of SD and of undisturbed control rats. Histidine 12-15 growth hormone releasing hormone receptor Rattus norvegicus 81-87 19389703-1 2009 This report addresses the functional role of His residues in the proton-coupled folate transporter (PCFT; SLC46A1), which mediates intestinal folate absorption. Histidine 45-48 solute carrier family 46 member 1 Homo sapiens 100-104 12167006-3 2002 It is shown that the specific hydrogen bond between His(101H) and Man C-4 OH is preserved in the gaseous complex. Histidine 52-55 complement C4A (Rodgers blood group) Homo sapiens 70-73 12167017-2 2002 We engineered a novel protein, "Antennafinger (Ant-F)", whose structure and function can be controlled with Zn(II), by introducing the consensus sequence of a Cys(2)His(2)-type zinc finger protein into a non-metalloprotein scaffold, an Antennapedia homeodomain mutant (Ant-wt), selected using a motif-searching system. Histidine 165-168 solute carrier family 25 member 6 Homo sapiens 32-35 12167017-2 2002 We engineered a novel protein, "Antennafinger (Ant-F)", whose structure and function can be controlled with Zn(II), by introducing the consensus sequence of a Cys(2)His(2)-type zinc finger protein into a non-metalloprotein scaffold, an Antennapedia homeodomain mutant (Ant-wt), selected using a motif-searching system. Histidine 165-168 solute carrier family 25 member 6 Homo sapiens 47-50 12167017-4 2002 The optical absorption spectra of the Co(II) complexes of Ant-F and its derivative proteins suggest that the geometry of the metal center of holo-Ant-F is tetrahedral and that the mutated Cys(2)His(2) residues are involved in the complex formation. Histidine 194-197 solute carrier family 25 member 6 Homo sapiens 58-61 12145341-7 2002 Conversely, the substitution of Y614 of the rFSHR with the cognate hFSHR residue (histidine) fully suppresses the constitutive activity of the rFSHR (D580G) mutant. Histidine 82-91 follicle stimulating hormone receptor Rattus norvegicus 44-49 12145341-7 2002 Conversely, the substitution of Y614 of the rFSHR with the cognate hFSHR residue (histidine) fully suppresses the constitutive activity of the rFSHR (D580G) mutant. Histidine 82-91 follicle stimulating hormone receptor Rattus norvegicus 143-148 12052343-6 2002 By addition of histidine hexamer at the C-terminal of boIL-18, the mature IL-18 was purified. Histidine 15-24 interleukin 18 Bos taurus 56-61 12106978-8 2002 Moreover, several histidine-inserted or -deleted hEGF mutants were prebound to rat liver sinusoidal membrane vesicle, followed by further incubation at 37 degrees C. The dissociation rate of histidine-deleted hEGF mutants was less rapid than that of hEGF itself. Histidine 191-200 epidermal growth factor Homo sapiens 49-53 12106978-8 2002 Moreover, several histidine-inserted or -deleted hEGF mutants were prebound to rat liver sinusoidal membrane vesicle, followed by further incubation at 37 degrees C. The dissociation rate of histidine-deleted hEGF mutants was less rapid than that of hEGF itself. Histidine 191-200 epidermal growth factor Homo sapiens 209-213 12106978-8 2002 Moreover, several histidine-inserted or -deleted hEGF mutants were prebound to rat liver sinusoidal membrane vesicle, followed by further incubation at 37 degrees C. The dissociation rate of histidine-deleted hEGF mutants was less rapid than that of hEGF itself. Histidine 191-200 epidermal growth factor Homo sapiens 209-213 11986319-2 2002 In this study, we identified His(308) and Arg(277) residues as essential determinants for the donor substrate (UDP-glucuronic acid) selectivity of the human GlcAT-I. Histidine 29-32 beta-1,3-glucuronyltransferase 3 Homo sapiens 157-164 11986319-10 2002 Our results are consistent with crucial interactions between the His(308) and Arg(277) residues and the glucuronic acid moiety that governs the specificity of GlcAT-I toward the nucleotide sugar donor substrate. Histidine 65-68 beta-1,3-glucuronyltransferase 3 Homo sapiens 159-166 11953431-7 2002 Two sequence motifs are found in common between human gamma-glutamyl hydrolase and the class I glutamine amidotransferase family and include the catalytically essential residues, Cys-110 and His-220. Histidine 191-194 gamma-glutamyl hydrolase Homo sapiens 54-78 12065763-6 2002 Substituting this histidine with arginine not only accelerated the time course of macroscopic channel inactivation but also eliminated the H+ effects on hKv1.4. Histidine 18-27 potassium voltage-gated channel subfamily A member 4 Homo sapiens 153-159 19389703-1 2009 This report addresses the functional role of His residues in the proton-coupled folate transporter (PCFT; SLC46A1), which mediates intestinal folate absorption. Histidine 45-48 solute carrier family 46 member 1 Homo sapiens 106-113 19388667-2 2009 It exhibits a novel protein fold, and in contrast to other 2Fe-2S proteins such as Rieske proteins and ferredoxins, the metal clusters in the mitoNEET homodimer are each coordinated by one histidine residue and three cysteine residues. Histidine 189-198 CDGSH iron sulfur domain 1 Homo sapiens 142-150 19028475-5 2009 Second, the Kvbeta subunits (AKR6A3, AKR6A5 and AKR6A9) which modulate opening of the voltage-gated potassium channel (Kv1) by oxidizing NADPH, have an Asn substituted for the His. Histidine 176-179 potassium voltage-gated channel subfamily A regulatory beta subunit 1 Homo sapiens 29-35 19028475-5 2009 Second, the Kvbeta subunits (AKR6A3, AKR6A5 and AKR6A9) which modulate opening of the voltage-gated potassium channel (Kv1) by oxidizing NADPH, have an Asn substituted for the His. Histidine 176-179 potassium voltage-gated channel subfamily A regulatory beta subunit 2 Homo sapiens 37-43 19212657-3 2009 Site-directed mutagenesis studies indicate that the proximal residue histidine 25 (His25) plays a key role in hHO-1 activity. Histidine 69-78 heme oxygenase 1 Homo sapiens 110-115 18952181-6 2009 In this work, the putative trpE gene of M. tuberculosis H37Rv was expressed as a fusion protein with a 6x His-tag on the N-terminal (His-TrpE) in Escherichia coli. Histidine 106-109 anthranilate synthase component I Mycobacterium tuberculosis H37Rv 27-31 18952181-6 2009 In this work, the putative trpE gene of M. tuberculosis H37Rv was expressed as a fusion protein with a 6x His-tag on the N-terminal (His-TrpE) in Escherichia coli. Histidine 133-136 anthranilate synthase component I Mycobacterium tuberculosis H37Rv 27-31 18952181-6 2009 In this work, the putative trpE gene of M. tuberculosis H37Rv was expressed as a fusion protein with a 6x His-tag on the N-terminal (His-TrpE) in Escherichia coli. Histidine 133-136 anthranilate synthase component I Mycobacterium tuberculosis H37Rv 137-141 19132843-0 2009 Role of histidine-86 in the catalytic mechanism of ferredoxin:thioredoxin reductase. Histidine 8-17 peroxiredoxin 5 Homo sapiens 62-83 18758694-1 2009 The full-length hNdrg2 cDNA-coded 357 amino acids was cloned and expressed in Escherichia coli strain DH5alpha as a 6x His-tagged protein. Histidine 119-122 NDRG family member 2 Homo sapiens 16-22 19139268-2 2009 Using a heterologous expression cloning approach, we isolated beta4GalNAcTB together with beta4GalNAcTB pilot (GABPI), a multimembrane-spanning protein related to Asp-His-His-Cys (DHHC) proteins but lacking the DHHC consensus sequence. Histidine 167-170 beta4GalNAcTB pilot Drosophila melanogaster 111-116 19000777-9 2009 Moreover, mutagenesis studies showed crucial roles of His-154 and Cys-241 of rat iNAT in the catalysis and a possible role of the N-terminal domain in membrane association or protein-protein interaction. Histidine 54-57 phospholipase A and acyltransferase 5 Rattus norvegicus 81-85 19085910-3 2009 Studies using recombinant CBS indicated that CO binds to the prosthetic heme, stabilizing 6-coordinated CO-Fe(II)-histidine complex to block the activity, whereas nitric oxide (NO) forms 5-coordinated structure without inhibiting it. Histidine 114-123 cystathionine beta-synthase Mus musculus 26-29 12110368-3 2002 Since several other enzymes of intermediary metabolism (e.g. ATP-citrate lyase and glucose-6-phosphatase) also undergo histidine phosphorylation, these initial findings may have a more generalized significance to beta cells. Histidine 119-128 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 83-104 12069902-7 2002 Point mutations were created to exchange the histidine and aspartate residues of the alpha1 and alpha5 subunits. Histidine 45-54 adrenoceptor alpha 1D Homo sapiens 85-91 12022880-6 2002 This study establishes the structure of the Ni site in resting Ni-ARD as containing a six coordinate Ni site composed of O/N-donor ligands including 3-4 histidine residues, demonstrates that the substrate binds to the Ni center in a bidentate fashion by displacing two ligands, at least one of which is a histidine ligand, and provides insight into the mechanism of catalysis employed by a Ni-containing dioxygenase. Histidine 153-162 acireductone dioxygenase 1 Homo sapiens 63-69 12022880-6 2002 This study establishes the structure of the Ni site in resting Ni-ARD as containing a six coordinate Ni site composed of O/N-donor ligands including 3-4 histidine residues, demonstrates that the substrate binds to the Ni center in a bidentate fashion by displacing two ligands, at least one of which is a histidine ligand, and provides insight into the mechanism of catalysis employed by a Ni-containing dioxygenase. Histidine 305-314 acireductone dioxygenase 1 Homo sapiens 63-69 12054669-5 2002 Hsc56 contains the -His-Pro-Glu- sequence corresponding to the His-Pro-Asp motif in DnaJ, which is indispensable for DnaJ to interact with DnaK. Histidine 20-23 DnaJ Escherichia coli 84-88 12054669-5 2002 Hsc56 contains the -His-Pro-Glu- sequence corresponding to the His-Pro-Asp motif in DnaJ, which is indispensable for DnaJ to interact with DnaK. Histidine 20-23 DnaJ Escherichia coli 117-121 12054669-5 2002 Hsc56 contains the -His-Pro-Glu- sequence corresponding to the His-Pro-Asp motif in DnaJ, which is indispensable for DnaJ to interact with DnaK. Histidine 63-66 DnaJ Escherichia coli 84-88 12054669-5 2002 Hsc56 contains the -His-Pro-Glu- sequence corresponding to the His-Pro-Asp motif in DnaJ, which is indispensable for DnaJ to interact with DnaK. Histidine 63-66 DnaJ Escherichia coli 117-121 11988102-6 2002 We took advantage of the functionality of the purified material to (i) develop an efficient surface-plasmon resonance assay of the interaction between two calcium channel subunits and (ii) measure, for the first time, the affinity of the recombinant His-beta(4) subunit for the full-length Ca(v)2.1 channel. Histidine 250-253 basic helix-loop-helix family member e23 L homeolog Xenopus laevis 254-261 18448192-2 2009 Triticain alpha, beta and gamma were constituted with 461, 472 and 365 amino acid residues, respectively, and had Cys-His-Asn catalytic triads as well as signal and propeptide sequences. Histidine 118-121 oryzain alpha chain Triticum aestivum 0-15 19384417-5 2009 The FLG2 gene encodes a histidine- and glutamine-rich protein of approximately 248 kDa, which shares common structural features with other SFTP members, in particular filaggrin. Histidine 24-33 filaggrin 2 Homo sapiens 4-8 11985867-2 2002 TCTP genes from B. malayi and W. bancrofti were expressed in a T7 promoter vector as histidine tagged fusion proteins. Histidine 85-94 tumor protein, translationally-controlled 1 Homo sapiens 0-4 11985867-3 2002 Both the recombinant B. malayi TCTP (rBm-TCTP) and recombinant W. bancrofti TCTP (rWb-TCTP) have a molecular mass of approximately 28 kDa with the histidine tag. Histidine 147-156 tumor protein, translationally-controlled 1 Homo sapiens 31-35 19384417-5 2009 The FLG2 gene encodes a histidine- and glutamine-rich protein of approximately 248 kDa, which shares common structural features with other SFTP members, in particular filaggrin. Histidine 24-33 filaggrin Homo sapiens 167-176 19206287-1 2008 We have demonstrated that nanostructures, and in particular nanorings incorporating a homodimeric enzyme, can be prepared by chemically induced self-assembly of dihydrofolate reductase (DHFR)-histidine triad nucleotide binding 1 (Hint1) fusion proteins. Histidine 192-201 dihydrofolate reductase Homo sapiens 161-184 19206287-1 2008 We have demonstrated that nanostructures, and in particular nanorings incorporating a homodimeric enzyme, can be prepared by chemically induced self-assembly of dihydrofolate reductase (DHFR)-histidine triad nucleotide binding 1 (Hint1) fusion proteins. Histidine 192-201 dihydrofolate reductase Homo sapiens 186-190 18848840-7 2008 Compared with individuals carrying genotypes of hOGG1 326Cys/Cys and hMYH 324His/His at the same time, there was a 0.33-fold (OR(adj), 0.33; 95% CI: 0.15-0.72; P<0.05) decreased risk of CBP for those with genotypes of hOGG1 326Ser/Cys+Ser/Ser and hMYH 324His/Gln+Gln/Gln. Histidine 77-80 8-oxoguanine DNA glycosylase Homo sapiens 48-53 11856731-2 2002 In particular, three amino acids that stabilize the transition state for the activation of tyrosine in B. stearothermophilus tyrosyl-tRNA synthetase (Cys-35, His-48, and Lys-233) are not present in the human enzyme. Histidine 158-161 tyrosyl-tRNA synthetase 1 Homo sapiens 125-148 11991203-1 2002 CD spectra of a tandem 27-mer repeat polypeptide, Gln-Pro-His-Gln-Pro-Leu-Gln-Pro-His-Gln-Pro-Leu-Gln-Pro-Met-(Gln-Pro-Leu)4, from bovine amelogenin synthesized by standard solid-phase synthesis manifests an archtypical CD pattern of a beta-spiral structure in phosphate buffer at pH 5.2 and trifluoroethanol (TFE), CF3OH. Histidine 58-61 amelogenin, X isoform Bos taurus 138-148 18848840-7 2008 Compared with individuals carrying genotypes of hOGG1 326Cys/Cys and hMYH 324His/His at the same time, there was a 0.33-fold (OR(adj), 0.33; 95% CI: 0.15-0.72; P<0.05) decreased risk of CBP for those with genotypes of hOGG1 326Ser/Cys+Ser/Ser and hMYH 324His/Gln+Gln/Gln. Histidine 77-80 8-oxoguanine DNA glycosylase Homo sapiens 221-226 19008408-0 2008 Histidine at codon 154 of the prion protein gene is a risk factor for Nor98 scrapie in goats. Histidine 0-9 major prion protein Ovis aries 30-43 11805111-1 2002 The histidine triad superfamily of nucleotide hydrolases and nucleotide transferases consists of a branch of proteins related to Hint and Aprataxin, a branch of Fhit-related hydrolases, and a branch of galactose-1-phosphate uridylyltransferase (GalT)-related transferases. Histidine 4-13 adenosine 5'-monophosphoramidase HINT1 Oryctolagus cuniculus 129-133 12419163-9 2002 In Western blot analysis, the single domain antibody from 2 of 4 clones proved to react with the His-tagged hTERT fusion protein (Mr = 167 000) without dependence of His-tags and also detect the native hTERT (Mr = 127 000) extracted from the human HeLa cancer cell line. Histidine 97-100 telomerase reverse transcriptase Homo sapiens 202-207 11788601-6 2002 Spectral transformations observed for TC in the slow phase were similar to those upon histidine complexation with Cbl x OH(2) and Cbi. Histidine 86-95 Cbl proto-oncogene Homo sapiens 114-117 11788601-10 2002 The above data suggest presence of a histidine-containing cap shielding the Cbl-binding site in TC. Histidine 37-46 Cbl proto-oncogene Homo sapiens 76-79 11756457-4 2002 Mutation of each of the two hERG1 histidines at positions 578 and 587 within the S(5)-S(6) linker generated K(+) channels insensitive to modulation by ROS. Histidine 34-44 potassium voltage-gated channel subfamily H member 2 Homo sapiens 28-33 11756457-7 2002 Collectively, the results obtained suggest that histidines at positions 578 and 587 in the S(5)-S(6) linker region of hERG1 K(+) channels are crucial players in ROS-induced modulation of hERG1 K(+) channels. Histidine 48-58 potassium voltage-gated channel subfamily H member 2 Homo sapiens 118-123 11756457-7 2002 Collectively, the results obtained suggest that histidines at positions 578 and 587 in the S(5)-S(6) linker region of hERG1 K(+) channels are crucial players in ROS-induced modulation of hERG1 K(+) channels. Histidine 48-58 potassium voltage-gated channel subfamily H member 2 Homo sapiens 187-192 11884629-0 2002 Involvement of conserved histidine, lysine and tyrosine residues in the mechanism of DNA cleavage by the caspase-3 activated DNase CAD. Histidine 25-34 DNA fragmentation factor, beta subunit Mus musculus 131-134 19261968-0 2008 Leptin influences histidine dipeptides and nitric oxide release from anterior pituitary cells of sheep in vitro. Histidine 18-27 leptin Ovis aries 0-6 18952862-5 2008 Mutational analysis of Arabidopsis (Arabidopsis thaliana) DEG15 revealed that conserved histidine, aspartic acid, and serine residues are essential for the proteolytic activity of this enzyme in vitro. Histidine 88-97 protease-like protein Arabidopsis thaliana 58-63 21836246-4 2008 Among the other amino acids, histidine is most efficient in quenching the emission of the CdS nanoparticles. Histidine 29-38 CDP-diacylglycerol synthase 1 Homo sapiens 90-93 18799458-7 2008 Structure-function analyses demonstrated that the C-terminal cysteine-histidine-rich domain of PCSK9 interacts specifically with the N-terminal repeat R1 of AnxA2. Histidine 70-79 proprotein convertase subtilisin/kexin type 9 Homo sapiens 95-100 18799458-7 2008 Structure-function analyses demonstrated that the C-terminal cysteine-histidine-rich domain of PCSK9 interacts specifically with the N-terminal repeat R1 of AnxA2. Histidine 70-79 annexin A2 Homo sapiens 157-162 19137672-4 2008 We demonstrate that one of the NDP kinase isoforms dynamically interacts with the retinal rod G protein transducin (Gt) and phosphorylates its beta-subunit at histidine residue (His 266). Histidine 159-168 cytidine/uridine monophosphate kinase 2 Homo sapiens 31-41 19137672-4 2008 We demonstrate that one of the NDP kinase isoforms dynamically interacts with the retinal rod G protein transducin (Gt) and phosphorylates its beta-subunit at histidine residue (His 266). Histidine 178-181 cytidine/uridine monophosphate kinase 2 Homo sapiens 31-41 18797193-5 2008 We identified a permissive region in the pore-loop of repeat IV within the Ca(V)2.1 alpha(1) subunit, which allowed integration of several different tags (hemagluttinine [HA], double HA; 6-histidine tag [His], 9-His, bungarotoxin-binding site) without compromising alpha(1) subunit protein expression (in transfected tsA-201 cells) and function (after expression in X. laevis oocytes). Histidine 204-207 adrenoceptor alpha 1D Homo sapiens 84-92 18797193-5 2008 We identified a permissive region in the pore-loop of repeat IV within the Ca(V)2.1 alpha(1) subunit, which allowed integration of several different tags (hemagluttinine [HA], double HA; 6-histidine tag [His], 9-His, bungarotoxin-binding site) without compromising alpha(1) subunit protein expression (in transfected tsA-201 cells) and function (after expression in X. laevis oocytes). Histidine 212-215 adrenoceptor alpha 1D Homo sapiens 84-92 18767117-8 2008 Supplementation of Lys, His, and Thr abrogated mTOR Ser 2448 phosphorylation, with no effect on Akt Ser 473-an mTORC2 target. Histidine 24-27 mechanistic target of rapamycin kinase Mus musculus 47-51 11844751-8 2002 Exchange of this His residue for Asn led to inactivation of MrsD. Histidine 17-20 MRSD Homo sapiens 60-64 11903230-5 2002 RESULTS: We identified a heterozygous arginine to histidine p63 mutation, R279H, in all three affected individuals. Histidine 50-59 tumor protein p63 Homo sapiens 60-63 11707435-4 2002 To study the ion selectivity of the AtNHX1 protein, we have purified a histidine-tagged version of the protein from yeast microsomes by Ni(2+) affinity chromatography, reconstituted the protein into lipid vesicles, and measured cation-dependent H(+) exchange with the fluorescent pH indicator pyranine. Histidine 71-80 Na+/H+ exchanger 1 Arabidopsis thaliana 36-42 11802740-0 2002 Rapid intrachain binding of histidine-26 and histidine-33 to heme in unfolded ferrocytochrome C. Time-resolved spectroscopic studies of unfolded horse iron(II) cytochrome c have suggested that the imidazole side chains of His26 and His33 bind transiently to the heme iron on microsecond time scales, after photodissociation of a carbon monoxide ligand from the heme. Histidine 28-37 cytochrome c, somatic Equus caballus 160-172 11802740-3 2002 Transient binding of these histidine side chains to the heme therefore generates one of the fast kinetic phases observed in previous photochemically triggered spectroscopic studies of dynamics in unfolded iron(II) cytochrome c. Histidine 27-36 cytochrome c, somatic Equus caballus 214-226 18767117-10 2008 The individual supplementation of Lys, His, and Thr maintained a low level of IRS-1 phosphorylation, which was dose-dependently increased by their combined addition. Histidine 39-42 insulin receptor substrate 1 Mus musculus 78-83 18557974-0 2008 A proline-to-histidine mutation in POU1F1 is associated with production traits in dairy cattle. Histidine 13-22 POU class 1 homeobox 1 Bos taurus 35-41 18557974-5 2008 An SNP in exon 3 of POU1F1 that changes a proline to a histidine was identified. Histidine 55-64 POU class 1 homeobox 1 Bos taurus 20-26 18768683-6 2008 Of the 23 members of the aspartate-histidine-histidine-cysteine (DHHC) domain containing proteins, DHHC-7 most strongly stimulated palmitoylation of NCAM, and enzyme activity was enhanced by FGF2. Histidine 35-44 neural cell adhesion molecule 1 Homo sapiens 149-153 18676617-3 2008 The Cys- and His-rich repeated N terminus (CH domain) of Upf1 has been implicated in its binding to Upf2. Histidine 13-16 ATP-dependent RNA helicase NAM7 Saccharomyces cerevisiae S288C 57-61 18676617-7 2008 Substitution of the coordinated Cys and His residues in the CH domain impaired not only self-ubiquitination of Upf1 but also rapid decay of aberrant mRNAs. Histidine 40-43 ATP-dependent RNA helicase NAM7 Saccharomyces cerevisiae S288C 111-115 18613721-7 2008 In previous studies HSMD (and HS Monte CarloHSMC) has been extended systematically to systems of increasing complexity, where the most recent is the seven-residue mobile loop, 304-310 (Gly-His-Gly-Ala-Gly-Gly-Ser) of the enzyme porcine pancreatic alpha-amylase modeled by the AMBER force field and AMBER with the implicit solvation GB/SA (paper I, Cheluvaraja, S.; Meirovitch, H. J. Chem. Histidine 189-192 amylase alpha 2A Homo sapiens 236-260 18384506-1 2008 Histidine-tagged human cardiotrophin-1 (hCT-1), a recently discovered cytokine with excellent therapeutic potential, was expressed in tobacco chloroplasts under the transcriptional and translational control of two different promoters (rrn and psbA) and 5"-untranslated regions (5"-UTRs) (psbA and phage T7 gene 10). Histidine 0-9 cardiotrophin 1 Homo sapiens 23-38 18384506-1 2008 Histidine-tagged human cardiotrophin-1 (hCT-1), a recently discovered cytokine with excellent therapeutic potential, was expressed in tobacco chloroplasts under the transcriptional and translational control of two different promoters (rrn and psbA) and 5"-untranslated regions (5"-UTRs) (psbA and phage T7 gene 10). Histidine 0-9 cardiotrophin 1 Homo sapiens 40-45 18596417-7 2008 Here, we summarize these findings with special emphasis on the histidine triad proteins Hint1 and Fhit and their repressive activity on the beta-catenin signaling function. Histidine 63-72 catenin beta 1 Homo sapiens 140-152 18222027-5 2008 The post-intake of histidine and carnosine significantly decreased MDA formations, increased GSH content, enhanced catalase and GPX activities, and suppressed CYP2E1 activity (P<0.05), in which the effects on catalase and CYP2E1 activities were dose-dependent (P<0.05). Histidine 19-28 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 159-165 18222027-5 2008 The post-intake of histidine and carnosine significantly decreased MDA formations, increased GSH content, enhanced catalase and GPX activities, and suppressed CYP2E1 activity (P<0.05), in which the effects on catalase and CYP2E1 activities were dose-dependent (P<0.05). Histidine 19-28 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 225-231 18405501-9 2008 Beta globin gene sequentiation showed the CD92 His --> Pro mutation Hb Newcastle in heterocygote condition in patient and her mother. Histidine 47-50 hemoglobin subunit beta Homo sapiens 0-11 18203721-0 2008 Deletion of a histidine-rich loop of AtMTP1, a vacuolar Zn(2+)/H(+) antiporter of Arabidopsis thaliana, stimulates the transport activity. Histidine 14-23 zinc transporter Arabidopsis thaliana 37-43 18203721-9 2008 We prepared a mutant AtMTP1 that lacked the major part (32 residues from 185 to 216) of a long histidine-rich hydrophilic loop in the central part of AtMTP1. Histidine 95-104 zinc transporter Arabidopsis thaliana 21-27 18325109-12 2008 CONCLUSION: Based on the results of our mutagenesis study, we conclude that the two histidine residues in close proximity to the chromophore are approximately equal determinants of the blue-shifted fluorescence emission of mTFP1. Histidine 84-93 mitochondrial fission process 1 Mus musculus 223-228 11738613-1 2002 A compound named HPH-Pep, a peptide constructed from pyridine and histidine units, showed sensitizing effect on the hyperthermic treatment of L-1210, Molt-4, and HL60 cells. Histidine 66-75 progestagen associated endometrial protein Homo sapiens 21-24 11717523-2 2001 In this study, the crystallization and preliminary crystallographic analysis of C-terminal His-tagged human AGT expressed in Escherichia coli is reported. Histidine 91-94 alanine--glyoxylate and serine--pyruvate aminotransferase Homo sapiens 108-111 18241934-2 2008 In order to develop a rapid and sensitive rotavirus group A LAT, part of segment 6 corresponding to conserved N-terminal portion of the VP6 (1-245 aa) was cloned in Escherichia coli expression pGEX vector (glutathione S-transferase-GST gene fusion system) that has been modified previously containing a histidine tail at C-terminus. Histidine 303-312 VP6 Rotavirus A 136-139 11698233-4 2001 When expressed in Xenopus laevis oocytes and in mammalian cells, rat SN2 mediates Na(+)-dependent transport of several neutral amino acids, including glycine, asparagine, alanine, serine, glutamine, and histidine. Histidine 203-212 solute carrier family 38, member 5 Rattus norvegicus 69-72 18227430-4 2008 To investigate whether this serine addition is assisted by the catalytic His-Asp dyad, we generated two mutants of DPP-IV, S630A and H740Q, and assayed them for ability to bind inhibitor. Histidine 73-76 dipeptidyl peptidase 4 Homo sapiens 115-121 26619992-5 2008 In this paper HSMD is developed further as applied to the flexible 7-residue surface loop, 304-310 (Gly-His-Gly-Ala-Gly-Gly-Ser) of the enzyme porcine pancreatic alpha-amylase. Histidine 104-107 amylase alpha 2A Homo sapiens 151-175 11527975-6 2001 SKCa3 was rendered sensitive to Lei-Dab(7) by replacing His(521) with the corresponding SKCa2 residue (Asn(367)). Histidine 56-59 potassium calcium-activated channel subfamily N member 3 Homo sapiens 0-5 11731082-8 2001 Subsequently, when the amino acid composition of CP reacted with AAPH was analyzed, cysteine, tryptophan, methionine, histidine, tyrosine, and lysine residues were particularly sensitive. Histidine 118-127 ceruloplasmin Homo sapiens 49-51 11687974-4 2001 5qNCA encodes a 191-kD nuclear protein which contains a highly-conserved C-terminus containing a zinc finger with the unique spacing Cys-X2-Cys-X7-His-X2-Cys-X2-Cys-X4-Cys-X2-Cys and a jmjC domain, which is often found in proteins that regulate chromatin remodeling. Histidine 147-150 lysine demethylase 3B Homo sapiens 0-5 11580291-6 2001 The functional epitope on human uPAR for this antagonist has been delineated by site-directed mutagenesis, and its assignment to loop 3 of uPAR domain III (Met(246), His(249), His(251), and Phe(256)) corroborates data previously obtained by photoaffinity labeling and provides a molecular explanation for the extreme selectivity observed for the antagonist toward human compared to mouse, monkey, and hamster uPAR. Histidine 166-169 plasminogen activator, urokinase receptor Homo sapiens 32-36 11580291-6 2001 The functional epitope on human uPAR for this antagonist has been delineated by site-directed mutagenesis, and its assignment to loop 3 of uPAR domain III (Met(246), His(249), His(251), and Phe(256)) corroborates data previously obtained by photoaffinity labeling and provides a molecular explanation for the extreme selectivity observed for the antagonist toward human compared to mouse, monkey, and hamster uPAR. Histidine 176-179 plasminogen activator, urokinase receptor Homo sapiens 32-36 18203258-4 2008 Site-specific, dose-dependent modification of Cys47 in native and His-tagged GSTP was revealed by MS, and correlated with inhibition of glutathione (GSH) conjugating activity. Histidine 66-69 glutathione S-transferase pi 1 Homo sapiens 77-81 18037383-0 2007 Histidine residues in the IS3-IS4 loop are critical for nickel-sensitive inhibition of the Cav2.3 calcium channel. Histidine 0-9 calcium voltage-gated channel subunit alpha1 E Homo sapiens 91-97 18037383-2 2007 As in Cav3.2, two histidine residues are commonly found in the IS3-IS4 loops of mammalian Cav2.3 Ca2+ channels, which are also blocked by low micromolar concentrations of nickel. Histidine 18-27 calcium voltage-gated channel subunit alpha1 E Homo sapiens 90-96 11567902-3 2001 Three active sites characteristic for cathepsin B were conserved in the deduced amino acid sequences of BmCtB cDNA at positions Cys-111, His-280 and Asn-300. Histidine 137-140 cathepsin B Bombyx mori 38-49 11447225-5 2001 Recombinant His(6)-Plk3 phosphorylated glutathione S-transferase (GST)-p53 fusion protein but not GST alone. Histidine 12-15 glutathione S-transferase kappa 1 Homo sapiens 39-64 11447225-5 2001 Recombinant His(6)-Plk3 phosphorylated glutathione S-transferase (GST)-p53 fusion protein but not GST alone. Histidine 12-15 glutathione S-transferase kappa 1 Homo sapiens 66-69 11531342-1 2001 A set of nine variants of yeast iso-1-cytochrome c with zero or one surface histidine have been engineered such that the N-terminal amino group is acetylated in vivo. Histidine 76-85 threonine ammonia-lyase ILV1 Saccharomyces cerevisiae S288C 32-37 17939663-2 2007 In the complex formed between morphinone reductase (MR) and the NADH analogue 1,4,5,6-tetrahydro-NADH (NADH4) the nicotinamide moiety is restrained close to the FMN isoalloxazine ring by hydrogen bonds from Asn-189 and His-186 as determined from the X-ray crystal structure. Histidine 219-222 formin 1 Homo sapiens 161-164 17939707-0 2007 Comment on "ultrafast dynamics of myoglobin without the distal histidine: stimulated vibrational echo experiments and molecular dynamics simulations". Histidine 63-72 myoglobin Homo sapiens 34-43 17905810-0 2007 Histidine cycle mechanism for the concerted proton/electron transfer from ascorbate to the cytosolic haem b centre of cytochrome b561: a unique machinery for the biological transmembrane electron transfer. Histidine 0-9 cytochrome b561 Homo sapiens 118-133 17709260-2 2007 YUH1 was fused with the 6 histidine tag at the N-terminus (H6YUH1) or C-terminus (YUH1H6) and purified by an immobilized metal affinity chromatography with high purity. Histidine 26-35 ubiquitin-specific protease YUH1 Saccharomyces cerevisiae S288C 0-4 17869271-4 2007 Our data demonstrate that exchanging Cys for His and vice versa in the highly conserved Zn-coordinating HCCH motif disrupted Vif function and interaction with Cul5. Histidine 45-48 cullin 5 Homo sapiens 159-163 17521902-0 2007 Oriented immobilisation of anti-pneumolysin Fab through a histidine tag for electrochemical immunosensors. Histidine 58-67 FA complementation group B Homo sapiens 44-47 17521902-3 2007 The orientation of recombinant histidine-tagged Fab fragments of monoclonal anti-pneumolysin antibodies on gold films is evaluated. Histidine 31-40 FA complementation group B Homo sapiens 48-51 17620335-5 2007 The epitope for 4B6.13 anti-TSP-2 was localized to His-722 and Leu-703 in repeat 1C of the wire; recognition only occurred in constructs that included EGF3, the rest of the wire, and the lectin-like module and in the presence of calcium. Histidine 51-54 thrombospondin 2 Homo sapiens 28-33 17644065-1 2007 Endostar, a novel recombinant human endostatin expressed and purified in Escherichia coli with an additional nine-amino acid sequence and forming another his-tag structure, was approved by the SFDA in 2005 for the treatment of non-small-cell lung cancer. Histidine 154-157 collagen type XVIII alpha 1 chain Homo sapiens 36-46 17763374-5 2007 Docking analysis indicated that the binding to D(2) and 5-HT(1A) receptors is based on (i) interaction between protonated N1 of the piperazine ring and various aspartate residues, (ii) hydrogen bonds between various moieties of the ligand and the residues of threonine, serine, histidine or tryptophane, and (iii) edge-to-face interactions of the aromatic ring of the arylpiperazine moiety with phenylalanine or tyrosine residues. Histidine 278-287 5-hydroxytryptamine receptor 1A Homo sapiens 56-63 11444980-7 2001 The active site general-base implicated by these kinetic results is believed to be His-334, of the highly conserved TGase Cys-His-Asp catalytic triad. Histidine 83-86 protein-glutamine gamma-glutamyltransferase 2 Cavia porcellus 116-121 11444980-7 2001 The active site general-base implicated by these kinetic results is believed to be His-334, of the highly conserved TGase Cys-His-Asp catalytic triad. Histidine 126-129 protein-glutamine gamma-glutamyltransferase 2 Cavia porcellus 116-121 11396977-4 2001 Under native conditions, the soluble cytosolic His(6)-hAR was purified to apparent homogeneity in the presence of dihydrotestosterone, using metal ion affinity chromatography. Histidine 47-50 lymphatic vessel endothelial hyaluronan receptor 1 Homo sapiens 54-57 11278664-4 2001 Because the pH dependence of ST8Sia II and IV enzyme activities and the pK profile of His residues are similar, we hypothesized that a histidine residue would be involved in their catalytic activity. Histidine 135-144 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 Homo sapiens 29-38 11278664-6 2001 His(348) in ST8Sia II and His(331) in ST8Sia IV, respectively) within the sialyl motif VS in all sialyltransferase genes cloned to date. Histidine 0-3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 Homo sapiens 12-21 17604220-5 2007 In the present work hexameric histidine tagged Faa1p was purified to homogeneity through a two-step process in the presence of 0.1% eta-dodecyl-beta-maltoside following expression at 15 degrees C in Escherichia coli. Histidine 30-39 long-chain fatty acid-CoA ligase FAA1 Saccharomyces cerevisiae S288C 47-52 17702678-1 2007 The Arabidopsis MAP kinase 4 (MPK4) substrate MKS1 was expressed in Escherichia coli and purified, full-length, 6x histidine (His)-tagged MKS1 was phosphorylated in vitro by hemagglutinin (HA)-tagged MPK4 immuno-precipitated from plants. Histidine 115-124 MAP kinase 4 Arabidopsis thaliana 16-28 17702678-1 2007 The Arabidopsis MAP kinase 4 (MPK4) substrate MKS1 was expressed in Escherichia coli and purified, full-length, 6x histidine (His)-tagged MKS1 was phosphorylated in vitro by hemagglutinin (HA)-tagged MPK4 immuno-precipitated from plants. Histidine 115-124 MAP kinase 4 Arabidopsis thaliana 30-34 17702678-1 2007 The Arabidopsis MAP kinase 4 (MPK4) substrate MKS1 was expressed in Escherichia coli and purified, full-length, 6x histidine (His)-tagged MKS1 was phosphorylated in vitro by hemagglutinin (HA)-tagged MPK4 immuno-precipitated from plants. Histidine 126-129 MAP kinase 4 Arabidopsis thaliana 16-28 17702678-1 2007 The Arabidopsis MAP kinase 4 (MPK4) substrate MKS1 was expressed in Escherichia coli and purified, full-length, 6x histidine (His)-tagged MKS1 was phosphorylated in vitro by hemagglutinin (HA)-tagged MPK4 immuno-precipitated from plants. Histidine 126-129 MAP kinase 4 Arabidopsis thaliana 30-34 17589432-4 2007 Synthetic melanoma-associated antigen MART1 mRNA was formulated with a polyethylene glycol (PEG)ylated derivative of histidylated polylysine and L-histidine-(N,N-di-n-hexadecylamine)ethylamide liposomes (termed histidylated lipopolyplexes). Histidine 145-156 melan-A Mus musculus 38-43 17587159-4 2007 Moreover, on SDS-polyacrylamide gel electrophoresis (SDS-PAGE) under nonreducing conditions, hexahistidine-tagged hGST P1-1 (His(6)-hGST P1-1) treated with 1 mM H(2)O(2) showed at least three extra bands, in addition to the native His(6)-hGST P1-1 subunit band. Histidine 125-128 glutathione S-transferase pi 1 Homo sapiens 114-123 17587159-4 2007 Moreover, on SDS-polyacrylamide gel electrophoresis (SDS-PAGE) under nonreducing conditions, hexahistidine-tagged hGST P1-1 (His(6)-hGST P1-1) treated with 1 mM H(2)O(2) showed at least three extra bands, in addition to the native His(6)-hGST P1-1 subunit band. Histidine 125-128 glutathione S-transferase pi 1 Homo sapiens 132-141 17587159-4 2007 Moreover, on SDS-polyacrylamide gel electrophoresis (SDS-PAGE) under nonreducing conditions, hexahistidine-tagged hGST P1-1 (His(6)-hGST P1-1) treated with 1 mM H(2)O(2) showed at least three extra bands, in addition to the native His(6)-hGST P1-1 subunit band. Histidine 231-234 glutathione S-transferase pi 1 Homo sapiens 114-123 17503777-8 2007 Sco1, a distantly related thioredoxin-fold protein, has histidine in place of the cis-proline, and this residue binds copper. Histidine 56-65 thioredoxin Homo sapiens 26-37 17210184-5 2007 We constructed the recombinant expression vector pET28a(+)/hALR with a full-length cDNA encoding hALR protein from normal human liver tissue by one-step reverse transcription-polymerase chain reaction and his-tag recognition sequence encoding polyhistidine (6 x His). Histidine 262-265 growth factor, augmenter of liver regeneration Homo sapiens 97-101 17194704-8 2007 The ferric state of the AHSP/alpha-Hb complex shows hexacoordination even at atmospheric pressures, indicating a His-Fe-His binding scheme as previously observed in neuroglobin and cytoglobin. Histidine 113-116 alpha hemoglobin stabilizing protein Homo sapiens 24-28 11300772-0 2001 Evidence for an essential histidine residue in the ascorbate-binding site of cytochrome b561. Histidine 26-35 cytochrome b561 Homo sapiens 77-92 11300822-5 2001 Electron paramagnetic resonance at 15 K further indicated that the iron-histidine bond is cleaved to form a five-coordinate derivative in some fraction of the myoglobin. Histidine 72-81 myoglobin Homo sapiens 159-168 11069919-6 2001 Although a AtCCME (Met(79)-Ser(256)) is not fully able to complement an Escherichia coli CcmE mutant strain for bacterial holocytochrome c production, it is able to bind heme covalently through a conserved histidine, a feature previously shown for E. coli CcmE. Histidine 206-215 transmembrane protein G1P-related 1 Arabidopsis thaliana 11-17 11069919-6 2001 Although a AtCCME (Met(79)-Ser(256)) is not fully able to complement an Escherichia coli CcmE mutant strain for bacterial holocytochrome c production, it is able to bind heme covalently through a conserved histidine, a feature previously shown for E. coli CcmE. Histidine 206-215 transmembrane protein G1P-related 1 Arabidopsis thaliana 256-260 11263872-1 2001 Early reports of a severely bent CO adduct in myoglobin inspired the idea that heme proteins discriminate against CO, relative to O(2), via steric hindrance imposed by a distal histidine residue. Histidine 177-186 myoglobin Homo sapiens 46-55 11148031-0 2001 Solution structure and dynamic character of the histidine-containing phosphotransfer domain of anaerobic sensor kinase ArcB from Escherichia coli. Histidine 48-57 hypothetical protein Escherichia coli 119-123 11148031-2 2001 Multidimensional NMR techniques were applied to determine the solution structure of the histidine-containing phosphotransfer signaling domain of ArcB (HPt(ArcB)), which has a phosphorylation site, His717. Histidine 88-97 hypothetical protein Escherichia coli 145-149 11148031-2 2001 Multidimensional NMR techniques were applied to determine the solution structure of the histidine-containing phosphotransfer signaling domain of ArcB (HPt(ArcB)), which has a phosphorylation site, His717. Histidine 88-97 hypothetical protein Escherichia coli 151-160 17194704-8 2007 The ferric state of the AHSP/alpha-Hb complex shows hexacoordination even at atmospheric pressures, indicating a His-Fe-His binding scheme as previously observed in neuroglobin and cytoglobin. Histidine 120-123 alpha hemoglobin stabilizing protein Homo sapiens 24-28 17211673-0 2007 Roles of putative His-to-Asp signaling modules HPT-1 and RRG-2, on viability and sensitivity to osmotic and oxidative stresses in Neurospora crassa. Histidine 18-21 hypoxanthine phosphoribosyltransferase Saccharomyces cerevisiae S288C 47-52 17190829-8 2007 Moreover, a kinetic analysis of purified His(6)-tagged RHM2-N protein revealed 5.9-fold higher affinity of RHM2 for UDP-D-glucose than for dTDP-D-glucose, the preferred substrate for dTDP-D-glucose 4,6-dehydratase from bacteria. Histidine 41-44 NAD-dependent epimerase/dehydratase family protein Arabidopsis thaliana 55-59 17084858-7 2007 Antibodies 3F1 through 3F4, which are similar to our previously identified 3A6 class of antibodies, catalyze hydrolysis through transition state stabilization by tyrosine or histidine residues H50 and L94. Histidine 174-183 histocompatibility 50 Mus musculus 193-196 11148034-1 2001 We have explored the ability of a nucleoside diphosphate kinase (NDPK) mutant in which the nucleophilic histidine has been replaced by glycine (H122G) to transfer phosphate from ATP to alcohols of varying pK(a), size, shape, and polarity. Histidine 104-113 cytidine/uridine monophosphate kinase 2 Homo sapiens 34-63 11148034-1 2001 We have explored the ability of a nucleoside diphosphate kinase (NDPK) mutant in which the nucleophilic histidine has been replaced by glycine (H122G) to transfer phosphate from ATP to alcohols of varying pK(a), size, shape, and polarity. Histidine 104-113 cytidine/uridine monophosphate kinase 2 Homo sapiens 65-69 11093950-8 2000 Diethylpyrocarbonate inhibition of iron uptake in DMT1-transfected cells suggests a functional role for histidine residues. Histidine 104-113 doublesex and mab-3 related transcription factor 1 Homo sapiens 50-54 17098236-2 2007 The medaka ppTRH cDNA codes for 270 amino acid residues including eight TRH progenitor sequences (-Lys/Arg-Arg-Gln-His-Pro-Gly-Lys/Arg-Arg-). Histidine 115-118 thyrotropin-releasing hormone Oryzias latipes 11-16 17584126-3 2007 Our initial efforts in this area have focused on affinity and selectivity directed optimization of the native beta-MSH(5-22) sequence and resulted in the discovery of a potent MC4R agonist: Ac-Tyr-Arg-[Cys-Glu-His-D-Phe-Arg-Trp-Cys]-NH(2) (10). Histidine 210-213 melanocortin 4 receptor Mus musculus 176-180 17166179-3 2007 CNBP is mainly conformed by seven retroviral Cys-Cys-His-Cys zinc-knuckles and a glycine/arginine rich region box. Histidine 53-56 CCHC-type zinc finger, nucleic acid binding protein a Danio rerio 0-4 17087501-2 2006 The sequence of DesA3 is homologous with those of other membrane desaturases, including the presence of the eight-His motif proposed to bind the diiron center active site. Histidine 114-117 stearoyl-CoA 9-desaturase Mycobacterium tuberculosis H37Rv 16-21 11191882-3 2000 We have found the following frequencies of mutated alleles: CYP1A1-m2, 0.097; CYP2E1-C, 0.077; CYP2E1-c2, 0.023; EPHX(exon 3)-His, 0.381; EPHX(exon 4)-Arg, 0.198; GSTM1-null, 0.51; GSTP1-Val, 0.3; GSTT1-null, 0.164. Histidine 126-129 epoxide hydrolase 1 Homo sapiens 113-117 11029294-10 2000 Other contributors to the distinct pH sensitivity were histidine residues in the COOH terminus, whose numbers are fewer in Kir4.1 than Kir1.1. Histidine 55-64 potassium inwardly rectifying channel subfamily J member 10 Homo sapiens 123-129 11029294-11 2000 Mutation of two of these histidine residues in Kir1.1 (H342Q/H354N) reduced CO(2)/pH sensitivities, whereas the creation of two histidines (S328H/G340H) in Kir4.1 increased the CO(2)/pH sensitivities. Histidine 25-34 potassium inwardly rectifying channel subfamily J member 10 Homo sapiens 156-162 11155228-4 2000 The zinc ion forms a stable complex with His 119(GH1) on the Mb surface at the equimolar Zn2+ concentration. Histidine 41-44 somatotropin Physeter catodon 49-52 10913119-3 2000 The phosphoryl group is transferred from one domain to another, with histidine as the phosphoryl acceptor in IIA and cysteine as the acceptor in certain IIB domains. Histidine 69-78 colicin Ia immunity protein Escherichia coli 109-112 11018678-3 2000 The complex formation of Zn(2+) with the central histidine-rich motif of B18 appears to shift the secondary structure away from a beta-sheet towards an alpha-helical conformation. Histidine 49-58 NADH:ubiquinone oxidoreductase subunit B7 Homo sapiens 73-76 10985787-2 2000 The binding of E12 was localized to the N-terminal, regulatory domain of VanR which contains Asp-55, the residue which accepts the phosphoryl group from His-164 in the activated VanS sensor kinase. Histidine 153-156 VanS protein Enterococcus faecium 178-182 11027165-3 2000 A recombinant vaccinia virus/T7 RNA polymerase expression system was developed to express and produce large amounts of gp120 tagged with six histidine residues. Histidine 141-150 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 119-124 11042490-2 2000 Plasmids with point mutations in ecoRII gene resulting in substitutions of amino acid residues in the Asp110-Glu112 region of the EcoRII endonuclease (Asp110 --> Lys, Asn, Thr, Val, or Ile; Pro111 --> Arg, His, Ala, or Leu; Glu112 --> Lys, Gln, or Asp) have been constructed. Histidine 212-215 EcoRII restriction enzyme Escherichia coli 33-39 11042490-2 2000 Plasmids with point mutations in ecoRII gene resulting in substitutions of amino acid residues in the Asp110-Glu112 region of the EcoRII endonuclease (Asp110 --> Lys, Asn, Thr, Val, or Ile; Pro111 --> Arg, His, Ala, or Leu; Glu112 --> Lys, Gln, or Asp) have been constructed. Histidine 212-215 EcoRII restriction enzyme Escherichia coli 130-136 10964668-2 2000 In Western blot analysis, hg303 recognizes both wild type and C-terminal Myc-His-tagged human DNase gamma, but does not cross-react with human DNase I family members, DNase I, DNase X, or DNAS1L2. Histidine 77-80 MYC proto-oncogene, bHLH transcription factor Homo sapiens 73-76 10964668-2 2000 In Western blot analysis, hg303 recognizes both wild type and C-terminal Myc-His-tagged human DNase gamma, but does not cross-react with human DNase I family members, DNase I, DNase X, or DNAS1L2. Histidine 77-80 deoxyribonuclease 1 like 3 Homo sapiens 94-105 10926844-8 2000 Mutation of two adjacent histidine residues within the predicted active site severely decreases activity, confirming these residues as important for HDAC8 enzyme activity. Histidine 25-34 histone deacetylase 8 Homo sapiens 149-154 10920044-7 2000 In addition to the C2-proton (H epsilon(1)) chemical shifts, these spectra also reveal the corresponding C4-proton (H delta(2)) resonances, correlated with the N epsilon(2) and N delta(1) chemical shifts of all 13 surface histidines per alpha beta dimer. Histidine 222-232 delta like canonical Notch ligand 4 Homo sapiens 116-126 10889031-9 2000 Further, it appears that a concerted cleavage of both His ligands takes place, suggesting indeed that the different axial ligands present in horse heart cytochrome c (Met/His) and in cytochrome c" from M. methylotrophus (His/His) affect the heme conformational changes. Histidine 54-57 cytochrome c, somatic Equus caballus 153-165 10889031-9 2000 Further, it appears that a concerted cleavage of both His ligands takes place, suggesting indeed that the different axial ligands present in horse heart cytochrome c (Met/His) and in cytochrome c" from M. methylotrophus (His/His) affect the heme conformational changes. Histidine 54-57 cytochrome c, somatic Equus caballus 183-195 10887113-7 2000 Through these interactions, HKa or its recombinant His-Gly-Lys-rich domain 5 completely inhibited the uPAR-dependent adhesion of myelomonocytic U937 cells and uPAR-transfected BAF-3 cells to VN and thereby promoted cell detachment. Histidine 51-54 plasminogen activator, urokinase receptor Homo sapiens 102-106 10887113-7 2000 Through these interactions, HKa or its recombinant His-Gly-Lys-rich domain 5 completely inhibited the uPAR-dependent adhesion of myelomonocytic U937 cells and uPAR-transfected BAF-3 cells to VN and thereby promoted cell detachment. Histidine 51-54 plasminogen activator, urokinase receptor Homo sapiens 159-163 10908322-2 2000 Mutant forms of hOgg1 with mutations Arg(46)-->Gln (alpha-hOgg1-Gln(46)) and Arg(154)-->His (alpha-hOgg1-His(154)) have previously been identified in human tumors. Histidine 94-97 8-oxoguanine DNA glycosylase Homo sapiens 16-21 10908322-2 2000 Mutant forms of hOgg1 with mutations Arg(46)-->Gln (alpha-hOgg1-Gln(46)) and Arg(154)-->His (alpha-hOgg1-His(154)) have previously been identified in human tumors. Histidine 111-114 8-oxoguanine DNA glycosylase Homo sapiens 16-21 10908322-3 2000 The mutant proteins alpha-hOgg1-Gln(46) and alpha-hOgg1-His(154) were expressed in Escherichia coli and purified to homogeneity. Histidine 56-59 8-oxoguanine DNA glycosylase Homo sapiens 50-55 10908322-15 2000 Taken together the results show that the mutant forms alpha-hOgg1-Gln(46) and alpha-hOgg1-His(154) found in human tumors are defective in their catalytic capacities. Histidine 90-93 8-oxoguanine DNA glycosylase Homo sapiens 60-65 10908322-15 2000 Taken together the results show that the mutant forms alpha-hOgg1-Gln(46) and alpha-hOgg1-His(154) found in human tumors are defective in their catalytic capacities. Histidine 90-93 8-oxoguanine DNA glycosylase Homo sapiens 84-89 16997281-2 2006 In this study we produced, and expressed in Xenopus oocytes, individual alanine point mutants of positively charged amino acids (eight lysine, seven arginine and one histidine) in the intracellular domains of the human P2X1 receptor. Histidine 166-175 purinergic receptor P2X 1 Homo sapiens 219-232 17022785-2 2006 Our study revealed a novel, homoplasmic T11984C missense mutation in ND4 gene, which replaces a highly conserved amino acid tyrosine with histidine. Histidine 138-147 mitochondrially encoded NADH dehydrogenase 4 Homo sapiens 69-72 10947842-0 2000 Tuning of the porin expression under anaerobic growth conditions by his-to-Asp cross-phosphorelay through both the EnvZ-osmosensor and ArcB-anaerosensor in Escherichia coli. Histidine 68-71 hypothetical protein Escherichia coli 135-139 11204523-2 2000 The substitution of arginine (R) to histidine (H) at amino acid residue 156 (R156H) of coiled 1A region is one of the most frequent mutations of KRT10. Histidine 36-45 keratin 10 Homo sapiens 145-150 10860823-0 2000 Functional roles of histidine and tyrosine residues in the H(+)-peptide transporter PepT1. Histidine 20-29 solute carrier family 15 member 1 Oryctolagus cuniculus 84-89 10841784-5 2000 Zn(II) binds to the N(tau) atom of the histidine imidazole ring and the peptide aggregates through intermolecular His(N(tau))-Zn(II)-His(N(tau)) bridges. Histidine 114-117 microtubule associated protein tau Homo sapiens 22-25 10841784-5 2000 Zn(II) binds to the N(tau) atom of the histidine imidazole ring and the peptide aggregates through intermolecular His(N(tau))-Zn(II)-His(N(tau)) bridges. Histidine 114-117 microtubule associated protein tau Homo sapiens 120-123 10841784-5 2000 Zn(II) binds to the N(tau) atom of the histidine imidazole ring and the peptide aggregates through intermolecular His(N(tau))-Zn(II)-His(N(tau)) bridges. Histidine 114-117 microtubule associated protein tau Homo sapiens 120-123 10841784-5 2000 Zn(II) binds to the N(tau) atom of the histidine imidazole ring and the peptide aggregates through intermolecular His(N(tau))-Zn(II)-His(N(tau)) bridges. Histidine 133-136 microtubule associated protein tau Homo sapiens 22-25 10841784-5 2000 Zn(II) binds to the N(tau) atom of the histidine imidazole ring and the peptide aggregates through intermolecular His(N(tau))-Zn(II)-His(N(tau)) bridges. Histidine 133-136 microtubule associated protein tau Homo sapiens 120-123 10841784-5 2000 Zn(II) binds to the N(tau) atom of the histidine imidazole ring and the peptide aggregates through intermolecular His(N(tau))-Zn(II)-His(N(tau)) bridges. Histidine 133-136 microtubule associated protein tau Homo sapiens 120-123 12526492-1 2000 The reaction of [Ru(bpy)2L(H2O)]2+ (bpy = 2,2"-bipyridine, L = imidazole, water) with reduced horse heart cytochrome c results in coordination of [RuII(bpy)2L] at the His 33 and His 26 sites. Histidine 167-170 cytochrome c, somatic Equus caballus 106-118 12526492-1 2000 The reaction of [Ru(bpy)2L(H2O)]2+ (bpy = 2,2"-bipyridine, L = imidazole, water) with reduced horse heart cytochrome c results in coordination of [RuII(bpy)2L] at the His 33 and His 26 sites. Histidine 178-181 cytochrome c, somatic Equus caballus 106-118 10801361-0 2000 Coupled kinetic traps in cytochrome c folding: His-heme misligation and proline isomerization. Histidine 47-50 cytochrome c, somatic Equus caballus 25-37 10801361-2 2000 The variant contains a single misligating His residue at position 26, a location at which His residues are found in several cytochrome c homologues, including horse, tuna, and yeast iso-1. Histidine 42-45 cytochrome c, somatic Equus caballus 124-136 10801361-2 2000 The variant contains a single misligating His residue at position 26, a location at which His residues are found in several cytochrome c homologues, including horse, tuna, and yeast iso-1. Histidine 42-45 threonine ammonia-lyase ILV1 Saccharomyces cerevisiae S288C 182-187 10799485-3 2000 Like yeast Ulp1, SUSP1 is a cysteine protease containing the well conserved His/Asp/Cys catalytic triad. Histidine 76-79 SUMO protease ULP1 Saccharomyces cerevisiae S288C 11-15 10769175-5 2000 The human Delta(5)-desaturase contained a predicted N-terminal cytochrome b(5)-like domain, as well as three histidine-rich domains. Histidine 109-118 fatty acid desaturase 1 Homo sapiens 10-29 10760284-1 2000 To understand the relevance of p53 missense mutations in vivo, we generated a mouse containing an arg-to-his substitution at p53 amino acid 172, which corresponds to the R175H hot-spot mutation in human tumors by homologous recombination. Histidine 105-108 transformation related protein 53, pseudogene Mus musculus 125-128 10864417-0 2000 Regional distribution of histamine H3 receptor binding sites in rat brain following L-histidine loading--an autoradiography study. Histidine 84-95 histamine receptor H3 Rattus norvegicus 25-46 10708444-7 2000 Furthermore, using proteins expressed in Escherichia coli, a glutathione S-transferase-Nef fusion protein coprecipitated histidine-tagged portions of the TCR zeta cytoplasmic domain which contained SNID-1 or SNID-2. Histidine 121-130 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 154-157 10734219-2 2000 The sixA gene was originally identified as the one that interferes with, at its multi-copy state, the cross-phosphorelay between the histidine-containing phosphotransmitter (HPt) domain of the ArcB anaerobic sensor and its non-cognate OmpR response regulator. Histidine 133-142 hypothetical protein Escherichia coli 193-197 10617633-7 2000 Point mutations of conserved cysteine residues or a histidine in the RING finger domain, which are required for zinc binding, abrogated the ability of Cbl to negatively regulate Syk in COS-7 cells and Ramos B lymphocytic cells. Histidine 52-61 Cbl proto-oncogene Homo sapiens 151-154 10585483-4 1999 ArcB is a tripartite kinase, possessing a primary transmitter, a receiver, and a secondary transmitter domain that catalyzes the phosphorylation of ArcA via a His --> Asp --> His --> Asp phosphorelay, as well as the dephosphorylation of ArcA-P by a reverse phosphorelay. Histidine 159-162 hypothetical protein Escherichia coli 0-4 10574918-10 1999 We generated a carboxyl-terminal histidine-tagged recombinant antithrombin III to study the tag on another serpin. Histidine 33-42 serpin family C member 1 Homo sapiens 62-78 17042779-2 2006 In order to characterize its enzymatic properties, the soluble form of the recombinant Och1p was expressed in the methylotrophic yeast Pichia pastoris as a secreted protein, after truncation of its transmembrane region and fusion with myc and histidine tags at the C-terminus, and purified using a metal chelating column. Histidine 243-252 initiation-specific alpha-1,6-mannosyltransferase Saccharomyces cerevisiae S288C 87-92 16901896-4 2006 The SNAP50 zinc finger domain contains 15 cysteine and histidine residues configured in two potential zinc coordination arrangements. Histidine 55-64 small nuclear RNA activating complex polypeptide 3 Homo sapiens 4-10 16901746-0 2006 Site-specific mutagenesis of the histidine precursor of diphthamide in the human elongation factor-2 gene confers resistance to diphtheria toxin. Histidine 33-42 eukaryotic translation elongation factor 2 Homo sapiens 81-100 16901746-1 2006 Protein synthesis elongation factor 2 (EF-2) from eukaryotes contains a conserved post-translationally modified histidine residue known as diphthamide. Histidine 112-121 eukaryotic translation elongation factor 2 Homo sapiens 18-37 16901746-1 2006 Protein synthesis elongation factor 2 (EF-2) from eukaryotes contains a conserved post-translationally modified histidine residue known as diphthamide. Histidine 112-121 eukaryotic translation elongation factor 2 Homo sapiens 39-43 16901746-4 2006 Using site-specific mutagenesis of the histidine precursor of diphthamide, the histidine residue of codon 715 in human EF-2 cDNA was substituted with one of four amino acid residue codons: leucine, methionine, asparagine or glutamine. Histidine 39-48 eukaryotic translation elongation factor 2 Homo sapiens 119-123 16901746-4 2006 Using site-specific mutagenesis of the histidine precursor of diphthamide, the histidine residue of codon 715 in human EF-2 cDNA was substituted with one of four amino acid residue codons: leucine, methionine, asparagine or glutamine. Histidine 79-88 eukaryotic translation elongation factor 2 Homo sapiens 119-123 16977317-6 2006 Modeling with F-actin predicts that the length of this WH2-containing arm is critical for severing function, and the addition of a single amino acid (alanine or histidine) eliminates CapG-sev severing activity, confirming this prediction. Histidine 161-170 capping actin protein, gelsolin like Homo sapiens 183-187 16844077-0 2006 Histidine residues in the region between transmembrane domains III and IV of hZip1 are required for zinc transport across the plasma membrane in PC-3 cells. Histidine 0-9 solute carrier family 39 member 1 Homo sapiens 77-82 16945939-6 2006 Although this configuration is similar to those of other beta-lactamases, TTHA0252 has one conserved His residue characteristic of the beta-CASP family as a ligand. Histidine 101-104 MBL fold metallo-hydrolase Thermus thermophilus HB8 74-82 10658591-4 1999 The amino acids found to be important for MDL103,392 binding to the NK-1 receptor are Gln-165, His-197, Leu-203, Ile-204, Phe-264, His-265 and Tyr-272. Histidine 95-98 tachykinin receptor 1 Homo sapiens 68-81 10658591-4 1999 The amino acids found to be important for MDL103,392 binding to the NK-1 receptor are Gln-165, His-197, Leu-203, Ile-204, Phe-264, His-265 and Tyr-272. Histidine 131-134 tachykinin receptor 1 Homo sapiens 68-81 10567372-8 1999 The putative active site residues serine, aspartic acid, and histidine of QPP show an ordering of the catalytic triad similar to that seen in the post-proline cleaving exopeptidases prolylcarboxypeptidase and CD26/dipeptidyl peptidase IV. Histidine 61-70 dipeptidyl peptidase 7 Homo sapiens 74-77 10567372-8 1999 The putative active site residues serine, aspartic acid, and histidine of QPP show an ordering of the catalytic triad similar to that seen in the post-proline cleaving exopeptidases prolylcarboxypeptidase and CD26/dipeptidyl peptidase IV. Histidine 61-70 dipeptidyl peptidase 4 Homo sapiens 209-213 10567372-8 1999 The putative active site residues serine, aspartic acid, and histidine of QPP show an ordering of the catalytic triad similar to that seen in the post-proline cleaving exopeptidases prolylcarboxypeptidase and CD26/dipeptidyl peptidase IV. Histidine 61-70 dipeptidyl peptidase 4 Homo sapiens 214-237 10567378-8 1999 A small fragment of p300 containing the carboxyl-terminal cysteine/histidine-rich domain, sufficient to interact with GATA-5, prevents transcriptional activation by GATA-5 as a dominant-negative mutant. Histidine 67-76 GATA binding protein 5 Homo sapiens 118-124 10567378-8 1999 A small fragment of p300 containing the carboxyl-terminal cysteine/histidine-rich domain, sufficient to interact with GATA-5, prevents transcriptional activation by GATA-5 as a dominant-negative mutant. Histidine 67-76 GATA binding protein 5 Homo sapiens 165-171 10625445-4 1999 The displacement from an interface with cytochrome c(1) in native crystals to an interface with cytochrome b is induced by stigmatellin or 5-n-undecyl-6-hydroxy-4,7-dioxobenzothiazole (UHDBT) and involves ligand formation between His-161 of the [2Fe-2S] binding cluster and the inhibitor. Histidine 230-233 cytochrome c, somatic Gallus gallus 40-52 10506413-6 1999 Starting with the NusA/hIL-3 fusion protein with an N-terminal histidine tag, purified hIL-3 with full biological activity was obtained using immobilized metal affinity chromatography, factor Xa protease cleavage, and anion exchange chromatography. Histidine 63-72 interleukin 3 Homo sapiens 87-92 10563629-6 1999 RESULTS: Maternal relatives harbor a G-to-A missense mutation, heteroplasmic in some patients, at nucleotide position 11778 of the mitochondrial ND4 gene of complex I that converts a highly conserved arginine to a histidine. Histidine 214-223 mitochondrially encoded NADH dehydrogenase 4 Homo sapiens 145-148 10516162-6 1999 The following were ruled out as the underlying mechanisms: 1) voltage shift in channel activation, 2) pore blockade by protons, 3) protonation of histidines on the extracellular domain of HERG, 4) acceleration of recovery from C-type inactivation, and 5) interaction between an external H(+) binding site and the cytoplasmic NH(2)-terminal domain (a key determinant of HERG deactivation rate). Histidine 146-156 potassium voltage-gated channel subfamily H member 2 Homo sapiens 188-192 10556563-8 1999 The other two cleavage sites in alpha(2)M by lebetase are Gly(679)-Leu(680) and His(694)-Ala(695). Histidine 80-83 alpha-2-macroglobulin Homo sapiens 32-41 10514264-7 1999 Protein C has twelve surface-accessible histidines, which are the major metal-binding groups for IMAC separation. Histidine 40-50 protein C, inactivator of coagulation factors Va and VIIIa Homo sapiens 0-9 16842804-0 2006 Adsorptive refolding of histidine-tagged glutathione S-transferase using metal affinity chromatography. Histidine 24-33 glutathione S-transferase kappa 1 Homo sapiens 41-66 16790357-2 2006 To investigate how GluR1-containing AMPA receptors contribute to dendrite morphogenesis, we characterized a mutant form of GluR1 (containing a histidine in the Q/R editing site) with unique electrophysiological properties. Histidine 143-152 glutamate ionotropic receptor AMPA type subunit 1 Homo sapiens 19-24 10501933-0 1999 The N-end rule pathway is required for import of histidine in yeast lacking the kinesin-like protein Cin8p. Histidine 49-58 kinesin motor protein CIN8 Saccharomyces cerevisiae S288C 101-106 10501933-5 1999 This defect in histidine uptake, exhibited by the sln2 mutant in the absence but not in the presence of Ubr1p, was traced to the gene HIP1, which encodes the histidine transporter. Histidine 15-24 histidine permease Saccharomyces cerevisiae S288C 134-138 10501933-9 1999 Thus, either the N-end rule pathway or Cin8p must be present for the viability-sustaining rate of histidine import in S. cerevisiae auxotrophic for histidine. Histidine 98-107 kinesin motor protein CIN8 Saccharomyces cerevisiae S288C 39-44 10501933-9 1999 Thus, either the N-end rule pathway or Cin8p must be present for the viability-sustaining rate of histidine import in S. cerevisiae auxotrophic for histidine. Histidine 148-157 kinesin motor protein CIN8 Saccharomyces cerevisiae S288C 39-44 10441372-5 1999 The His-CytKIR was tyrosine phosphorylated by Lck in vitro, and the phosphorylated His-CytKIR recruited SHP-1. Histidine 4-7 LCK proto-oncogene, Src family tyrosine kinase Homo sapiens 46-49 10451024-6 1999 GST-AA-NAT enzyme activity is also inhibited by reagents that are known biochemically to modify thiol groups (N-ethylmaleimide, NEM) and histidine residues (p-chloromercuribenzoate, NBS and diethyl pyrocarbonate, DEPC), suggesting the presence of essential cysteine and histidine moieties. Histidine 137-146 aralkylamine N-acetyltransferase Rattus norvegicus 4-10 10451024-6 1999 GST-AA-NAT enzyme activity is also inhibited by reagents that are known biochemically to modify thiol groups (N-ethylmaleimide, NEM) and histidine residues (p-chloromercuribenzoate, NBS and diethyl pyrocarbonate, DEPC), suggesting the presence of essential cysteine and histidine moieties. Histidine 270-279 aralkylamine N-acetyltransferase Rattus norvegicus 4-10 10451024-7 1999 Moreover, preincubation of acetyl CoA completely protects the recombinant AA-NAT from inactivation by NEM and DEPC, indicating that specific cysteine and histidine residues may be at the acetylation site. Histidine 154-163 aralkylamine N-acetyltransferase Rattus norvegicus 74-80 10469826-4 1999 Further optimization can often be achieved by flipping the side chains of asparagine, histidine and glutamine around their chi2, chi2 and chi3 torsion angles, respectively, when this improves the local hydrogen bonding network. Histidine 86-95 chitinase 1 Homo sapiens 138-142 10393098-0 1999 Histidine-193 of rat glucosylceramide synthase resides in a UDP-glucose- and inhibitor (D-threo-1-phenyl-2-decanoylamino-3-morpholinopropan-1-ol)-binding region: a biochemical and mutational study. Histidine 0-9 UDP-glucose ceramide glucosyltransferase Rattus norvegicus 21-46 10393098-5 1999 The histidine-modifying agent diethyl pyrocarbonate (DEPC) inhibited recombinant rat GCS expressed in bacteria; this inhibition was rapidly reversible by hydroxylamine and could be diminished by preincubation of GCS with UDP-Glc. Histidine 4-13 UDP-glucose ceramide glucosyltransferase Rattus norvegicus 85-88 10393098-5 1999 The histidine-modifying agent diethyl pyrocarbonate (DEPC) inhibited recombinant rat GCS expressed in bacteria; this inhibition was rapidly reversible by hydroxylamine and could be diminished by preincubation of GCS with UDP-Glc. Histidine 4-13 UDP-glucose ceramide glucosyltransferase Rattus norvegicus 212-215 10393098-6 1999 These data suggest that DEPC acts on histidine residues within or near the UDP-Glc-binding site of GCS. Histidine 37-46 UDP-glucose ceramide glucosyltransferase Rattus norvegicus 99-102 10393098-7 1999 Mutant proteins were expressed in which the eight histidine residues in GCS were individually replaced by other amino acids. Histidine 50-59 UDP-glucose ceramide glucosyltransferase Rattus norvegicus 72-75 10387025-3 1999 Furthermore, in a physiological assay involving mouse muscle nAChR expressed in Xenopus oocytes, the His-tagged Bgtx was as effective as authentic Bgtx at blocking acetylcholine-evoked currents. Histidine 101-104 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 61-66 10424441-4 1999 To better understand the molecular interaction between KIR and TCR zeta-chain, we generated a His-tag fusion protein of a p70 KIR cytoplasmic tail (His-CytKIR) and used this protein to coprecipitate TCR zeta-chain from Jurkat T cells. Histidine 148-151 CD247 molecule Homo sapiens 63-77 10424441-4 1999 To better understand the molecular interaction between KIR and TCR zeta-chain, we generated a His-tag fusion protein of a p70 KIR cytoplasmic tail (His-CytKIR) and used this protein to coprecipitate TCR zeta-chain from Jurkat T cells. Histidine 148-151 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 63-66 10424441-6 1999 Interestingly, the association between the His-CytKIR and TCR zeta was dependent on the phosphorylation of the His-CytKIR. Histidine 43-46 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 58-61 10424441-6 1999 Interestingly, the association between the His-CytKIR and TCR zeta was dependent on the phosphorylation of the His-CytKIR. Histidine 111-114 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 58-61 10350625-10 1999 For cholesterol esterase, carbamates 8-10 are more potent than carbamates S-2, 4, and 5 probably due to the fact that the inhibitor molecules interact with the second alkyl chain binding site of the enzyme through a hydrogen bond between the phenol hydroxy group of the inhibitor molecules and the His 435 residue in that site. Histidine 298-301 carboxyl ester lipase Homo sapiens 4-24 10350627-3 1999 The deduced amino acid sequence of CA-RP XI showed an overall similarity of 42-53% to the active site residues of other active CA isozymes; however, it lacked three zinc-binding histidine residues, raising questions regarding its CA catalytic activity. Histidine 178-187 carbonic anhydrase 11 Homo sapiens 35-43 10229683-4 1999 Deoxyhypusine synthase was selectively retained by His.Tag-ec-eIF5A immobilized on a resin. Histidine 51-54 eukaryotic translation initiation factor 5A Homo sapiens 62-67 10318862-4 1999 Here, we report that substitution of glutamine for either of two putative active site histidines in the PP2A C subunit results in inactivation of PP2A and formation of stable complexes between PP2A and several cellular proteins. Histidine 86-96 protein phosphatase 2 catalytic subunit alpha Homo sapiens 104-110 10318862-4 1999 Here, we report that substitution of glutamine for either of two putative active site histidines in the PP2A C subunit results in inactivation of PP2A and formation of stable complexes between PP2A and several cellular proteins. Histidine 86-96 protein phosphatase 2 phosphatase activator Homo sapiens 104-108 10318862-4 1999 Here, we report that substitution of glutamine for either of two putative active site histidines in the PP2A C subunit results in inactivation of PP2A and formation of stable complexes between PP2A and several cellular proteins. Histidine 86-96 protein phosphatase 2 phosphatase activator Homo sapiens 146-150 10233054-3 1999 A histidine at position 355 in the Kv1.1 channel protein (homologous to Shaker 425) was responsible for this pH-dependent reduction of TEA+ sensitivity, since the TEA+ effect became independent of pHo after chemical modification of the Kv1.1 channel at H355 and in the H355G and H355K mutant Kv1.1 channels. Histidine 2-11 potassium voltage-gated channel subfamily A member 1 Homo sapiens 35-40 10233054-3 1999 A histidine at position 355 in the Kv1.1 channel protein (homologous to Shaker 425) was responsible for this pH-dependent reduction of TEA+ sensitivity, since the TEA+ effect became independent of pHo after chemical modification of the Kv1.1 channel at H355 and in the H355G and H355K mutant Kv1.1 channels. Histidine 2-11 potassium voltage-gated channel subfamily A member 1 Homo sapiens 236-241 10233054-3 1999 A histidine at position 355 in the Kv1.1 channel protein (homologous to Shaker 425) was responsible for this pH-dependent reduction of TEA+ sensitivity, since the TEA+ effect became independent of pHo after chemical modification of the Kv1.1 channel at H355 and in the H355G and H355K mutant Kv1.1 channels. Histidine 2-11 potassium voltage-gated channel subfamily A member 1 Homo sapiens 236-241 10385247-7 1999 Mutations of threonine 100 and arginine 102 at the extracellular side of transmembrane II of the guinea-pig 5-HT1D receptor to the corresponding primate residues, isoleucine and histidine, respectively, enhanced its affinity for isochromans to that of the gorilla receptor, with little effects on its affinities for serotonin, sumatriptan and metergoline. Histidine 178-187 5-hydroxytryptamine receptor 1D Cavia porcellus 108-123 10402203-0 1999 Identification and mechanism of action of two histidine residues underlying high-affinity Zn2+ inhibition of the NMDA receptor. Histidine 46-55 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 113-126 10206957-3 1999 Instead, a serine, histidine, and two aspartic acids are important for signal peptidase activity by the Sec11p subunit of the yeast signal peptidase complex. Histidine 19-28 signal peptidase complex catalytic subunit SEC11 Saccharomyces cerevisiae S288C 104-110 10218494-2 1999 However, another form of GnRH of unknown function (pGlu-His-Trp-Ser-His-Gly-Trp-Tyr-Pro-Gly; GnRH-II) is expressed in the mesencephalon of all vertebrate classes except jawless fish. Histidine 56-59 gonadotropin releasing hormone 1 Mus musculus 25-29 10218494-2 1999 However, another form of GnRH of unknown function (pGlu-His-Trp-Ser-His-Gly-Trp-Tyr-Pro-Gly; GnRH-II) is expressed in the mesencephalon of all vertebrate classes except jawless fish. Histidine 56-59 gonadotropin releasing hormone 1 Mus musculus 93-97 10087163-1 1999 The ligand-binding domain of the rat vitamin D receptor (amino acids 115-423) was expressed as an amino-terminal His-tagged protein in a bacterial expression system and purified over Ni-nitrilotriacetic acid resin and a Mono S column. Histidine 113-116 vitamin D receptor Rattus norvegicus 37-55 10103027-4 1999 We reconstituted the p66/p51 heterodimer from subunits coexpressed in Escherichia coli as an N-terminal fusion protein of glutathione S-transferase (GST) with p51 and a C-terminally His-tagged p66, respectively. Histidine 182-185 DNA polymerase delta 3, accessory subunit Homo sapiens 21-24 10103027-4 1999 We reconstituted the p66/p51 heterodimer from subunits coexpressed in Escherichia coli as an N-terminal fusion protein of glutathione S-transferase (GST) with p51 and a C-terminally His-tagged p66, respectively. Histidine 182-185 tumor protein p63 Homo sapiens 25-28 10103041-12 1999 The allergen encoded by Pen c 1 gene was expressed in Escherichia coli as a fusion protein bearing an N-terminal histidine-affinity tag. Histidine 113-122 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 24-27 10103041-12 1999 The allergen encoded by Pen c 1 gene was expressed in Escherichia coli as a fusion protein bearing an N-terminal histidine-affinity tag. Histidine 113-122 heterogeneous nuclear ribonucleoprotein C Homo sapiens 28-31 10090732-5 1999 When the T state interface is weakened by Asp --> Asn substitution at a quaternary H-bond (HbK), the Fe-His bond is relaxed and becomes responsive to allosteric effectors. Histidine 107-110 hemoglobin subunit mu Homo sapiens 94-97 10022850-5 1999 Zta bound directly to two related cysteine- and histidine-rich domains of CBP, referred to as C/H1 and C/H3. Histidine 48-57 SUN domain containing ossification factor Homo sapiens 94-107 10191072-4 1999 However, most cyclostome braconids have either a "DK" or a "DHK" arrangement (where "H" refers to the tRNA gene for Histidine). Histidine 116-125 transfer RNA:Lysine-TTT 2-2 Drosophila melanogaster 102-106 10368279-5 1999 RESULTS: The crystal structure of a stable quadruple mutant of PAI-1(Asn150-->His, Lys154-->Thr, Gln319-->Leu, Met354-->Ile) in its active conformation has been solved at a nominal 3 A resolution. Histidine 81-84 serpin family E member 1 Homo sapiens 63-68 10499104-4 1999 The electronic absorption and MCD spectra of the engineered K(+)-site APX mutant are essentially identical to those of cytochrome b5, a known bis-imidazole (histidine) ligated heme system. Histidine 157-166 cytochrome b5 type A Homo sapiens 119-132 10024463-6 1999 Recombinant P5, with an N terminal extension of 10 residues that included six histidines, was cloned and expressed in Escherichia coli. Histidine 78-88 protein disulfide isomerase family A, member 6 Rattus norvegicus 12-14 10433084-2 1999 In these cells the protein was effectively expressed and ICA69 carrying C-terminal histidine-hexapeptide could be efficiently purified using immobilized metal chelate affinity chromatography. Histidine 83-92 islet cell autoantigen 1 Homo sapiens 57-62 9854036-4 1999 Mouse GSTT1-1 was expressed in Escherichia coli as an N-terminal 6x histidine-tagged protein and purified using immobilized-metal affinity chromatography on nickel-agarose. Histidine 68-77 glutathione S-transferase, theta 1 Mus musculus 6-13 9882662-6 1999 The homologous genes (uppS) were cloned from E. coli, Haemophilus influenzae, and Streptococcus pneumoniae, expressed in E. coli as amino-terminal His-tagged fusion proteins, and purified over a Ni2+ affinity column. Histidine 147-150 uppS Streptococcus pneumoniae R6 22-26 9852079-0 1998 Affinity purification and partial characterization of a yeast multiprotein complex for nucleotide excision repair using histidine-tagged Rad14 protein. Histidine 120-129 DNA repair protein RAD14 Saccharomyces cerevisiae S288C 137-142 9852079-4 1998 To examine this model further, we have constructed a histidine-tagged version of the yeast DNA damage recognition protein Rad14. Histidine 53-62 DNA repair protein RAD14 Saccharomyces cerevisiae S288C 122-127 9837973-8 1998 Rat FTCD is structurally similar to porcine FTCD, a metabolic enzyme involved in conversion of histidine to glutamic acid, and exists in dimeric, tetrameric, and octameric complexes resistant to proteolysis. Histidine 95-104 formimidoyltransferase cyclodeaminase Rattus norvegicus 4-8 9837973-8 1998 Rat FTCD is structurally similar to porcine FTCD, a metabolic enzyme involved in conversion of histidine to glutamic acid, and exists in dimeric, tetrameric, and octameric complexes resistant to proteolysis. Histidine 95-104 formimidoyltransferase cyclodeaminase Rattus norvegicus 44-48 9826622-4 1998 We expressed histidine-tagged rat cardiac myosin motor domains along with rat ventricular light chain 1 in mammalian COS cells. Histidine 13-22 myosin heavy chain 14 Homo sapiens 42-48 9853614-2 1998 Human formyl peptide receptor like-1 (FPRL-1) receptor, originally identified as an orphan G protein-coupled receptor related to the formyl peptide receptor (FPR1), was expressed in Saccharomyces cells designed to couple receptor activation to histidine prototrophy. Histidine 244-253 formyl peptide receptor 2 Homo sapiens 6-36 9853614-2 1998 Human formyl peptide receptor like-1 (FPRL-1) receptor, originally identified as an orphan G protein-coupled receptor related to the formyl peptide receptor (FPR1), was expressed in Saccharomyces cells designed to couple receptor activation to histidine prototrophy. Histidine 244-253 formyl peptide receptor 2 Homo sapiens 38-44 9792674-0 1998 Lysine 58 and histidine 66 at the C-terminal alpha-helix of monocyte chemoattractant protein-1 are essential for glycosaminoglycan binding. Histidine 14-23 C-C motif chemokine ligand 2 Homo sapiens 60-94 9792674-4 1998 We substituted lysine or histidine residues at the C-terminal end of MCP-1 with alanine residues and tested these mutants for their ability to bind heparin, heparan sulfate, hyaluronic acid, and chondroitin sulfate-C. Histidine 25-34 C-C motif chemokine ligand 2 Homo sapiens 69-74 9792674-9 1998 Therefore, we conclude that the Lys-58 and His-66 residues in the C-terminal alpha-helix of MCP-1 are essential for glycosaminoglycan binding and probably for the binding to the endothelial surface proteoglycans. Histidine 43-46 C-C motif chemokine ligand 2 Homo sapiens 92-97 9839942-0 1998 The role of distal histidine in peroxidase activity of myoglobin--transient-kinetics study of the reaction of H2O2 with wild-type and distal-histidine-mutanted recombinant human myoglobin. Histidine 19-28 myoglobin Homo sapiens 55-64 9839942-0 1998 The role of distal histidine in peroxidase activity of myoglobin--transient-kinetics study of the reaction of H2O2 with wild-type and distal-histidine-mutanted recombinant human myoglobin. Histidine 141-150 myoglobin Homo sapiens 55-64 9839942-0 1998 The role of distal histidine in peroxidase activity of myoglobin--transient-kinetics study of the reaction of H2O2 with wild-type and distal-histidine-mutanted recombinant human myoglobin. Histidine 141-150 myoglobin Homo sapiens 178-187 9839942-3 1998 The effect of mutation of the distal histidine on the peroxidase activity of Mb has been investigated by stopped-flow kinetics of the reaction of hydrogen peroxide with wild-type Mb and [Gly64]Mb. Histidine 37-46 myoglobin Homo sapiens 77-79 9839942-5 1998 The rate of reaction of H2O2 with the wild-type Mb decreased 8-9-fold on mutation of the distal histidine to glycine ([Gly64]Mb). Histidine 96-105 myoglobin Homo sapiens 48-50 9839942-5 1998 The rate of reaction of H2O2 with the wild-type Mb decreased 8-9-fold on mutation of the distal histidine to glycine ([Gly64]Mb). Histidine 96-105 myoglobin Homo sapiens 125-127 9771897-0 1998 An Arabidopsis protein that interacts with the cytokinin-inducible response regulator, ARR4, implicated in the His-Asp phosphorylay signal transduction. Histidine 111-114 response regulator 4 Arabidopsis thaliana 87-91 9748314-1 1998 Histidine-63, one of the heme axial ligands in outer mitochondrial membrane cytochrome b5 (OM cyt b5) has been replaced by a methionine. Histidine 0-9 cytochrome b5 type A Homo sapiens 76-89 16790357-2 2006 To investigate how GluR1-containing AMPA receptors contribute to dendrite morphogenesis, we characterized a mutant form of GluR1 (containing a histidine in the Q/R editing site) with unique electrophysiological properties. Histidine 143-152 glutamate ionotropic receptor AMPA type subunit 1 Homo sapiens 123-128 16891471-6 2006 However, these cells did undergo apoptosis in response to another form of recombinant TRAIL, histidine-tagged TRAIL, suggesting differing contributions of DR4 and DR5 in the response to these two forms of TRAIL. Histidine 93-102 TNF receptor superfamily member 10b Homo sapiens 163-166 16636053-6 2006 Mutations of His/Cys residues in the HCCH motif impair zinc coordination, Cul5 binding, and APOBEC3G degradation. Histidine 13-16 cullin 5 Homo sapiens 74-78 16754992-5 2006 Here, Drep-3 was expressed with a C-terminal His tag in Escherichia coli and the protein was purified to homogeneity. Histidine 45-48 DNA fragmentation factor-related protein 3 Drosophila melanogaster 6-12 16817893-9 2006 Enzymatic analysis of the purified hexamer His-AtUGD1 revealed that AtUGD1 activity is strongly inhibited by UDP-D-xylose, suggesting that AtUGD1 maintains intracellular levels of UDP-D-glucose in cooperation with AtUXS3 via the inhibition of AtUGD1 by UDP-D-xylose. Histidine 43-46 UDP-glucose dehydrogenase 1 Arabidopsis thaliana 47-53 16817893-9 2006 Enzymatic analysis of the purified hexamer His-AtUGD1 revealed that AtUGD1 activity is strongly inhibited by UDP-D-xylose, suggesting that AtUGD1 maintains intracellular levels of UDP-D-glucose in cooperation with AtUXS3 via the inhibition of AtUGD1 by UDP-D-xylose. Histidine 43-46 UDP-glucose dehydrogenase 1 Arabidopsis thaliana 68-74 16817893-9 2006 Enzymatic analysis of the purified hexamer His-AtUGD1 revealed that AtUGD1 activity is strongly inhibited by UDP-D-xylose, suggesting that AtUGD1 maintains intracellular levels of UDP-D-glucose in cooperation with AtUXS3 via the inhibition of AtUGD1 by UDP-D-xylose. Histidine 43-46 UDP-glucose dehydrogenase 1 Arabidopsis thaliana 68-74 16817893-9 2006 Enzymatic analysis of the purified hexamer His-AtUGD1 revealed that AtUGD1 activity is strongly inhibited by UDP-D-xylose, suggesting that AtUGD1 maintains intracellular levels of UDP-D-glucose in cooperation with AtUXS3 via the inhibition of AtUGD1 by UDP-D-xylose. Histidine 43-46 UDP-glucose dehydrogenase 1 Arabidopsis thaliana 68-74 16554024-1 2006 A half-type ABC transporter, human TAP-like (hTAPL) tagged with histidine cluster, was expressed in budding yeast protease-deficient strain BJ5457, and the effect of expression for resistance to peptide compounds including antibiotics and proteinase inhibitor was examined. Histidine 64-73 ATP binding cassette subfamily B member 9 Homo sapiens 45-50 16678114-0 2006 RAP uses a histidine switch to regulate its interaction with LRP in the ER and Golgi. Histidine 11-20 LDL receptor related protein associated protein 1 Homo sapiens 0-3 16678114-4 2006 The solution structure of RAP-D3 domain presented here reveals a striking increase in positively charged residues on the surface of this RAP domain due to protonation of solvent-exposed histidine sidechains as the pH is reduced from a near neutral pH of the ER to the acidic pH of the Golgi. Histidine 186-195 LDL receptor related protein associated protein 1 Homo sapiens 26-29 16678114-4 2006 The solution structure of RAP-D3 domain presented here reveals a striking increase in positively charged residues on the surface of this RAP domain due to protonation of solvent-exposed histidine sidechains as the pH is reduced from a near neutral pH of the ER to the acidic pH of the Golgi. Histidine 186-195 LDL receptor related protein associated protein 1 Homo sapiens 137-140 16678114-5 2006 Structure-based mutagenesis studies in vitro and in cells confirm that the protonation of histidine residues as a consequence of the pH changes modulate the binding/release of RAP from LRP. Histidine 90-99 LDL receptor related protein associated protein 1 Homo sapiens 176-179 16396634-2 2006 Anti-rCRDH1 phage clones were obtained after four rounds of screening with rCRDH1-coated immunotubes and single positive colonies were further selected with the expressed thioredoxin-His-S tag of the wild-type pET32c. Histidine 183-186 thioredoxin Homo sapiens 171-182 9790586-2 1998 The mutation was found to be located in HIP1, a gene known to encode a high-affinity permease for histidine. Histidine 98-107 histidine permease Saccharomyces cerevisiae S288C 40-44 9680483-8 1998 A buried salt bridge involving a histidine on the Max LZ and two glutamate residues on the c-Myc LZ is observed at the interface of the heterodimeric LZ. Histidine 33-42 MYC proto-oncogene, bHLH transcription factor Homo sapiens 91-96 16784457-2 2006 A variety of dicarboxylic acid linkers introduced between the alpha-amino group of His(6) and the epsilon-amino group of Lys(10) lead to high-affinity, selective human melanocortin receptor-1 and -5 (hMC1R and hMC5R) antagonists. Histidine 83-86 melanocortin 1 receptor Homo sapiens 168-198 9704652-3 1998 The patient"s serum was used to clone a dek complementary DNA, which was expressed as a histidine-tagged fusion protein in Escherichia coli. Histidine 88-97 DEK proto-oncogene Homo sapiens 40-43 9777417-9 1998 MASP of the second group has structural features which are distinct from those of the first group: an absence of a histidine loop, an active-serine encoded by AGY, and an alanine or valine as the amino acid residue at the -3 position from the active-serine. Histidine 115-124 MBL associated serine protease 1 Homo sapiens 0-4 9683496-0 1998 A dual-signaling mechanism mediated by the ArcB hybrid sensor kinase containing the histidine-containing phosphotransfer domain in Escherichia coli. Histidine 84-93 hypothetical protein Escherichia coli 43-47 9683496-2 1998 ArcB is a hybrid sensor kinase having multiple phosphorylation sites in its primary amino acid sequence, including a transmitter, a receiver, and a histidine-containing phosphotransfer (HPt) domain. Histidine 148-157 hypothetical protein Escherichia coli 0-4 9683496-4 1998 Results of recent in vitro studies revealed multistep His-to-Asp phosphotransfer circuitry in the ArcB-ArcA signaling system. Histidine 54-57 hypothetical protein Escherichia coli 98-102 9683496-6 1998 The results suggested that the phosphorylated His-717 site in the HPt domain of ArcB is essential for anaerobic repression of sdh. Histidine 46-49 hypothetical protein Escherichia coli 80-84 9683496-7 1998 Nonetheless, the ArcB mutant lacking this crucial His-717 site does not necessarily exhibit a null phenotype with respect to ArcB-ArcA signaling. Histidine 50-53 hypothetical protein Escherichia coli 17-21 9671798-3 1998 Among the proton-sucrose symporters cloned to date, only the histidine residue at position 65 of AtSUC1 from Arabidopsis thaliana is conserved across species. Histidine 61-70 sucrose-proton symporter 1 Arabidopsis thaliana 97-103 9655916-1 1998 Basic amino acids Arg, Lys, and His in the Cys2His2 zinc fingers of transcription factor IIIA (TFIIIA) potentially have important roles in factor binding to the extended internal control region (ICR) of the 5S ribosomal gene. Histidine 32-35 general transcription factor 3A L homeolog Xenopus laevis 68-93 9655916-1 1998 Basic amino acids Arg, Lys, and His in the Cys2His2 zinc fingers of transcription factor IIIA (TFIIIA) potentially have important roles in factor binding to the extended internal control region (ICR) of the 5S ribosomal gene. Histidine 32-35 general transcription factor 3A L homeolog Xenopus laevis 95-101 9494086-3 1998 The histidine-tagged human green cone pigment was functionally expressed in large-scale suspension cultures in Sf9 insect cells using recombinant baculovirus. Histidine 4-13 opsin 1, medium wave sensitive Homo sapiens 27-45 9488685-3 1998 In this study, we examined the interaction of the dipeptides and beta-lactam antibiotics with the histidine residue of rat PEPT1 and PEPT2 transfected into the renal epithelial cell line LLC-PK1. Histidine 98-107 solute carrier family 15 member 1 Rattus norvegicus 123-128 9488685-8 1998 These findings suggest that the alpha-amino group of beta-lactam antibiotics interacts with the histidine residue of PEPT1 and PEPT2 and may be involved in the mechanism of substrate recognition by the peptide transporters. Histidine 96-105 solute carrier family 15 member 1 Rattus norvegicus 117-122 9734335-6 1998 Aminopeptidase Ey contains the metallo-binding sequence motif, His-Glu-Xaa-His, found in zinc metallopeptidases. Histidine 63-66 alanyl aminopeptidase, membrane Gallus gallus 0-17 9734335-6 1998 Aminopeptidase Ey contains the metallo-binding sequence motif, His-Glu-Xaa-His, found in zinc metallopeptidases. Histidine 75-78 alanyl aminopeptidase, membrane Gallus gallus 0-17 16784457-2 2006 A variety of dicarboxylic acid linkers introduced between the alpha-amino group of His(6) and the epsilon-amino group of Lys(10) lead to high-affinity, selective human melanocortin receptor-1 and -5 (hMC1R and hMC5R) antagonists. Histidine 83-86 melanocortin 1 receptor Homo sapiens 200-205 16537570-9 2006 Surprisingly, cells expressing torsinA with the polymorphic histidine developed inclusions similar to those associated with DeltaGAG-torsinA, indicating that this change may also affect torsinA structure. Histidine 60-69 torsin family 1 member A Homo sapiens 31-38 16432504-7 2006 Chiral alpha-branched analogues exhibited a marked stereoselectivity at the H3R and H4R, the enantiomers with a configuration equivalent to L-histidine being preferred at both receptors. Histidine 140-151 histamine receptor H3 Homo sapiens 76-79 16432504-7 2006 Chiral alpha-branched analogues exhibited a marked stereoselectivity at the H3R and H4R, the enantiomers with a configuration equivalent to L-histidine being preferred at both receptors. Histidine 140-151 histamine receptor H4 Homo sapiens 84-87 16595957-7 2006 This 1B-His binding assay will be useful not only for the determination of Gb3 content, but also for screening for the compounds which inhibit the toxin-binding to Gb3. Histidine 8-11 alpha 1,4-galactosyltransferase (P blood group) Homo sapiens 75-78 9480763-2 1998 A variant of yeast iso-1-cytochrome c designated TM, which lacks all histidine residues except His18, still shows evidence of denatured state heme ligation in the pH range between 5 and 6 where normally only histidine ligation is expected. Histidine 69-78 threonine ammonia-lyase ILV1 Saccharomyces cerevisiae S288C 19-24 9480763-2 1998 A variant of yeast iso-1-cytochrome c designated TM, which lacks all histidine residues except His18, still shows evidence of denatured state heme ligation in the pH range between 5 and 6 where normally only histidine ligation is expected. Histidine 208-217 threonine ammonia-lyase ILV1 Saccharomyces cerevisiae S288C 19-24 9480763-5 1998 The N-terminal amino group thus competes with histidine for misligation of iso-1-cytochrome c under denaturing conditions. Histidine 46-55 threonine ammonia-lyase ILV1 Saccharomyces cerevisiae S288C 75-80 9463486-7 1998 Enzymatically active hST1B2 was expressed in the bacterial expression vector pKK233-2 for kinetic characterization and in the bacterial expression vector pQE-31, which generates a histidine-tagged fusion protein for the generation of antibodies. Histidine 180-189 sulfotransferase family 1B member 1 Homo sapiens 21-27 9489669-0 1998 An Escherichia coli protein that exhibits phosphohistidine phosphatase activity towards the HPt domain of the ArcB sensor involved in the multistep His-Asp phosphorelay. Histidine 148-151 hypothetical protein Escherichia coli 110-114 9489669-1 1998 The Escherichia coli sensory kinase, ArcB, possesses a histidine-containing phosphotransfer (HPt) domain, which is implicated in the His-Asp multistep phosphorelay. Histidine 55-64 hypothetical protein Escherichia coli 37-41 9489669-1 1998 The Escherichia coli sensory kinase, ArcB, possesses a histidine-containing phosphotransfer (HPt) domain, which is implicated in the His-Asp multistep phosphorelay. Histidine 133-136 hypothetical protein Escherichia coli 37-41 16595957-7 2006 This 1B-His binding assay will be useful not only for the determination of Gb3 content, but also for screening for the compounds which inhibit the toxin-binding to Gb3. Histidine 8-11 alpha 1,4-galactosyltransferase (P blood group) Homo sapiens 164-167 16289537-4 2006 The hPHT1 full-sequence was amplified from BeWo cells, inserted into the pcDNA3.1-V5/His TOPO plasmid and transiently transfected into COS-7 cells to investigate the uptake kinetics of [3H]histidine and [3H]carnosine. Histidine 189-198 solute carrier family 15 member 4 Homo sapiens 4-9 16289537-7 2006 Histidine and carnosine uptake was linear in hPHT1-COS-7 cells over 15 min and was found to be pH-dependent. Histidine 0-9 solute carrier family 15 member 4 Homo sapiens 45-50 16540079-5 2006 Synthesis and evaluation of LAH mutants provided evidence that the transfection efficiency depends on the number and positioning of histidine residues in the peptide as well as on the pH at which the in-plane to transmembrane transition takes place. Histidine 132-141 desmoglein 4 Homo sapiens 28-31 9425114-8 1998 No sequence similarity to the human fragile histidine triad protein, as found in the Ap4A hydrolase from Schizosaccharomyces pombe, was detected in the Ap4A hydrolase from lupin. Histidine 44-53 nudix hydrolase 2 Sus scrofa 85-99 9396728-4 1997 The results obtained indicate that His-13 of P21 co-ordinates to the sixth co-ordination position of the haem iron, thus leading to the formation of a complex characterized by an equilibrium between an "open" and a "closed" structure, as confirmed by molecular dynamics simulations. Histidine 35-38 H3 histone pseudogene 16 Homo sapiens 45-48 9396728-5 1997 Under acidic pH conditions, where His-13 of P21 is loosely bound to the haem iron ("open" conformation), MKP displays appreciable, quasi-reversible electrochemical activity; in contrast, at neutral pH ("closed" conformation) electrochemical behaviour is negligible, indicating that P21 interferes with the electron-transfer properties typical of Mp. Histidine 34-37 H3 histone pseudogene 16 Homo sapiens 44-47 9388263-3 1997 To determine if the equivalent residue in the related thiol ester-containing protein human alpha2-macroglobulin (alpha2M), asparagine 1065, plays a similar role, we have expressed and characterized four alpha2M variants in which this asparagine has been replaced by aspartate, alanine, histidine, or lysine. Histidine 286-295 alpha-2-macroglobulin Homo sapiens 113-120 9486427-6 1997 Six tryptophan/histidine signals and one tyrosine signal are present in the aromatic part of the CIDNP difference spectrum of SAP. Histidine 15-24 amyloid P component, serum Homo sapiens 126-129 16637264-8 2006 Theoretical possibility of copper transfer from His-Cys-His CTR1 C-terminal motif to cytosolic Cys-X-X-Cys Cu(I) chaperon sites has been shown. Histidine 48-51 solute carrier family 31 member 1 Homo sapiens 60-64 9364964-5 1997 Furthermore, this complex can be reconstituted in vitro by adding recombinant STI1 containing an amino-terminal histidine tag to promastigote lysate and subsequent purification using metal chelate affinity chromatography. Histidine 112-121 Hsp90 cochaperone STI1 Saccharomyces cerevisiae S288C 78-82 16637264-8 2006 Theoretical possibility of copper transfer from His-Cys-His CTR1 C-terminal motif to cytosolic Cys-X-X-Cys Cu(I) chaperon sites has been shown. Histidine 56-59 solute carrier family 31 member 1 Homo sapiens 60-64 16328052-4 2006 rHAUSP cDNA encodes 3,312 bp and 1,103 amino acids with a molecular weight of approximately 135 kDa containing highly conserved Cys, Asp (I), His, and Asn/Asp (II) domains characteristic of the ubiquitin-specific processing proteases. Histidine 142-145 ubiquitin specific peptidase 7 Rattus norvegicus 0-6 16842121-4 2006 In the cells over-expressing caspase-3, Western blotting with an anti-His-tag antibody confirmed the presence of caspase-3 in the three bands that were proposed to correspond to the precursor form (33 kDa), the mature forms processed at the prodomain alone (29 kDa, large subunit) and small sub unit (13 kD). Histidine 70-73 caspase 3, apoptosis-related cysteine peptidase a Danio rerio 29-38 16842121-4 2006 In the cells over-expressing caspase-3, Western blotting with an anti-His-tag antibody confirmed the presence of caspase-3 in the three bands that were proposed to correspond to the precursor form (33 kDa), the mature forms processed at the prodomain alone (29 kDa, large subunit) and small sub unit (13 kD). Histidine 70-73 caspase 3, apoptosis-related cysteine peptidase a Danio rerio 113-122 16330094-4 2005 rpL23-GFP-His is among the fusion proteins used in our previous study for ribosomal coupling of C-terminally His-tagged green fluorescent protein. Histidine 10-13 ribosomal protein L23 Mus musculus 0-5 16330094-4 2005 rpL23-GFP-His is among the fusion proteins used in our previous study for ribosomal coupling of C-terminally His-tagged green fluorescent protein. Histidine 109-112 ribosomal protein L23 Mus musculus 0-5 16330094-6 2005 We therefore purified rpL23-GFP-His, rpL23-His and GFP from E. coli recombinants using affinity, ion exchange and hydrophobic interaction chromatography. Histidine 32-35 ribosomal protein L23 Mus musculus 22-27 16226749-4 2005 Recombinant histidine-tagged human PCNA can substitute for purified endogenous human PCNA to initiate human chromosomal DNA replication. Histidine 12-21 proliferating cell nuclear antigen Homo sapiens 35-39 16226749-4 2005 Recombinant histidine-tagged human PCNA can substitute for purified endogenous human PCNA to initiate human chromosomal DNA replication. Histidine 12-21 proliferating cell nuclear antigen Homo sapiens 85-89 15927448-4 2005 We previously observed that bacterially expressed his-p68 was phosphorylated at multiple sites including serine/threonine and tyrosine [L. Yang, Z.R. Histidine 50-53 DEAD-box helicase 5 Homo sapiens 54-57 16361827-7 2005 This is the first report to characterize AQP2 mutations in Korean patients with autosomal recessive CNDI, and expands the spectrum of AQP2 mutations by reporting two novel mutation, 70Ala (GCC) to Asp (GAC) and 187Arg (CGC) to His (CAC). Histidine 227-230 aquaporin 2 Homo sapiens 134-138 16246823-2 2005 We replaced Ser71 in Mc b5 with Leu, with the prediction that it would retard heme loss by diminishing polypeptide expansion accompanying rupture of the histidine to iron bonds. Histidine 153-162 cytochrome b5 type A Homo sapiens 21-26 16285720-7 2005 Remarkable similarities between the results obtained in this study and those reported previously for the related Cbl-dependent isomerase methylmalonyl-CoA mutase indicate that a common mechanism by which the cofactor"s Co-C bond is activated for homolytic cleavage may be operative for all base-off/His-on Cbl-dependent isomerases. Histidine 299-302 Cbl proto-oncogene Homo sapiens 113-116 16285720-7 2005 Remarkable similarities between the results obtained in this study and those reported previously for the related Cbl-dependent isomerase methylmalonyl-CoA mutase indicate that a common mechanism by which the cofactor"s Co-C bond is activated for homolytic cleavage may be operative for all base-off/His-on Cbl-dependent isomerases. Histidine 299-302 Cbl proto-oncogene Homo sapiens 306-309 16061414-0 2005 Catalytic mechanism of S-adenosylhomocysteine hydrolase: roles of His 54, Asp130, Glu155, Lys185, and Aspl89. Histidine 66-69 adenosylhomocysteinase Homo sapiens 23-55 16196090-6 2005 The His(6)-RB/GST-E7 interaction was challenged by spotting the His(6)-RB solution in the presence of a RB binding peptide (PepC) derived from a motif on E7. Histidine 4-7 peptidase C Homo sapiens 124-128 16109718-3 2005 Analysis of ATF3 mRNA turnover revealed that the half-life was increased from about 1 h in control cells to greater than 8 h in the histidine-deprived state, demonstrating mRNA stabilization in response to nutrient deprivation. Histidine 132-141 activating transcription factor 3 Homo sapiens 12-16 16109718-10 2005 In contrast, the interaction of AUF1 with the ATF3 mRNA is decreased in histidine-deprived cells relative to control cells. Histidine 72-81 activating transcription factor 3 Homo sapiens 46-50 16177094-6 2005 Interestingly, they differ at the residue corresponding to the thioester-catalytic histidine, as seen in the human C4A and C4B isotypes, suggesting their distinct substrate specificities in the binding reaction of the thioester. Histidine 83-92 complement C4A (Rodgers blood group) Homo sapiens 115-126 16095919-3 2005 Pharmacological studies using specific ligands demonstrated a typical opioid profile for the HuMOR-c-myc-his-tag construct, whereas the GFP-HuMOR-c-myc-his-tag receptor was unable to bind opioid drugs. Histidine 105-108 MYC proto-oncogene, bHLH transcription factor Homo sapiens 99-104 16084833-15 2005 Consequently, single point mutants rTAXI-IIA[P294L] and rTAXI-IIB[Q376H], both displaying the Leu/His combination corresponding to TAXI-I, were able to inhibit ANX. Histidine 98-101 chitinase CLP Triticum aestivum 36-42 16834223-5 2005 The most stable conformers and the enthalpies of neutral and protonated histidine and its methyl ester are calculated at the G3(MP2) level of theory. Histidine 72-81 tryptase pseudogene 1 Homo sapiens 128-131 16834223-8 2005 Proton affinity (PA) of histidine calculated by the G3(MP2) method is 233.2 and 232.4 kcal mol(-1) for protonation at the imidazole ring and at the amino group nitrogens, respectively, which is about 3-5 kcal mol(-1) lower than the reported experimental value. Histidine 24-33 tryptase pseudogene 1 Homo sapiens 55-58 15958283-14 2005 Rat Bex3 protein can likely bind transition metals through a histidine-rich domain. Histidine 61-70 brain expressed X-linked 3 Rattus norvegicus 4-8 9340197-0 1997 A cluster of cytoplasmic histidine residues specifies pH dependence of the AE2 plasma membrane anion exchanger. Histidine 25-34 solute carrier family 4 member 2 Homo sapiens 75-78 9265630-4 1997 Homology searches using the 10 amino acid sequence SxHxxGxAxD, in which histidine and aspartate residues are putative zinc ligands, identified the metal coordinating ligands in the N-terminal domain of the murine Sonic hedgehog protein, which also exhibits an architecture for metal coordination identical to that observed in thermolysin from Bacillus thermoproteolyticus. Histidine 72-81 sonic hedgehog Mus musculus 213-235 9268342-7 1997 Furthermore, the predicted secondary structure of LysoPLA I resembles that of the alpha/beta-hydrolase fold, with Ser-119, Asp-174, and His-208 occupying the conserved topological location of the catalytic triad in the alpha/beta-hydrolases. Histidine 136-139 lysophospholipase 1 Mus musculus 50-59 9242632-7 1997 The putative catalytic site histidine residue present in the inner core domains of all dihydrolipoamide acyltransferases is replaced by a serine residue in human E3BP; thus, catalysis of coenzyme A acetylation by this protein is unlikely. Histidine 28-37 pyruvate dehydrogenase complex component X Homo sapiens 162-166 9242668-7 1997 Only hMOR-his was expressed at a level allowing binding study, but no difference could be detected in the affinities of both agonists and antagonists compared with the nontagged protein. Histidine 10-13 opioid receptor mu 1 Homo sapiens 5-9 9268679-1 1997 A method for expression and purification of active cytosolic heterodimeric histidine (His)-tagged guanylyl cyclase of the alpha 1/beta 1 isoform has been developed using recombinant baculovirus-transfected insect cells. Histidine 75-84 adrenoceptor alpha 1D Homo sapiens 122-129 9268679-1 1997 A method for expression and purification of active cytosolic heterodimeric histidine (His)-tagged guanylyl cyclase of the alpha 1/beta 1 isoform has been developed using recombinant baculovirus-transfected insect cells. Histidine 86-89 adrenoceptor alpha 1D Homo sapiens 122-129 9256341-2 1997 We demonstrated previously that individuals affected with an autosomal dominant disorder of skull morphogenesis (craniosynostosis, Boston type) bear a mutated form of Msx2 in which a histidine is substituted for a highly conserved proline in position 7 of the N-terminal arm of the homeodomain (p148h). Histidine 183-192 msh homeobox 2 Rattus norvegicus 167-171 15976002-4 2005 Histidine (His)-tagged soluble RAP (amino acids 39 to 356) lacking the amino-terminal signal peptide and the carboxy-terminal endoplasmic reticulum retention signal was prepared by bacterial expression (designated His-sRAP). Histidine 0-9 steroid receptor RNA activator 1 Mus musculus 218-222 15976002-4 2005 Histidine (His)-tagged soluble RAP (amino acids 39 to 356) lacking the amino-terminal signal peptide and the carboxy-terminal endoplasmic reticulum retention signal was prepared by bacterial expression (designated His-sRAP). Histidine 0-3 steroid receptor RNA activator 1 Mus musculus 218-222 15976002-5 2005 After the direct interaction between His-sRAP and megalin was confirmed, mice were given a single intraperitoneal administration of His-sRAP (3.5 mg/dose). Histidine 37-40 steroid receptor RNA activator 1 Mus musculus 41-45 15976002-5 2005 After the direct interaction between His-sRAP and megalin was confirmed, mice were given a single intraperitoneal administration of His-sRAP (3.5 mg/dose). Histidine 132-135 steroid receptor RNA activator 1 Mus musculus 136-140 15976002-6 2005 Immunostaining and Western blot analyses demonstrated the uptake of His-sRAP and the accelerated internalization of megalin in proximal tubular cells 1 h after administration. Histidine 68-71 steroid receptor RNA activator 1 Mus musculus 72-76 15976002-11 2005 The results suggest that the His-sRAP-induced acceleration of megalin-mediated endocytosis caused phosphaturia via altered subcellular distribution of NaPi-II. Histidine 29-32 steroid receptor RNA activator 1 Mus musculus 33-37 15976002-11 2005 The results suggest that the His-sRAP-induced acceleration of megalin-mediated endocytosis caused phosphaturia via altered subcellular distribution of NaPi-II. Histidine 29-32 low density lipoprotein receptor-related protein 2 Mus musculus 62-69 15908428-1 2005 Herein, we report the heterologous expression of the human peroxisomal 63-kDa calcium-independent phospholipase A2gamma (iPLA2gamma) isoform in Sf9 cells, purification of the N-terminal His-tagged enzyme by affinity chromatography, and the identification of its remarkable substrate selectivity that results in the highly selective generation of 2-arachidonoyl lysophosphatidylcholine. Histidine 186-189 patatin like phospholipase domain containing 8 Homo sapiens 78-119 15908428-1 2005 Herein, we report the heterologous expression of the human peroxisomal 63-kDa calcium-independent phospholipase A2gamma (iPLA2gamma) isoform in Sf9 cells, purification of the N-terminal His-tagged enzyme by affinity chromatography, and the identification of its remarkable substrate selectivity that results in the highly selective generation of 2-arachidonoyl lysophosphatidylcholine. Histidine 186-189 patatin like phospholipase domain containing 8 Homo sapiens 121-131 15912551-4 2005 The results indicated that the haem of C357M cytochrome P450cam is possibly axially coordinated to a methionine and a histidine, analogously to cytochrome c. Histidine 118-127 cytochrome c, somatic Equus caballus 144-156 16176092-10 2005 This suggested that pET-His-beta3/BL21(DE3)plysS was a suitable expression system for beta3, and the expressed beta3 specially inhibited the adhesion of cancer cells. Histidine 24-27 eukaryotic translation elongation factor 1 beta 2 pseudogene 2 Homo sapiens 28-33 16176092-10 2005 This suggested that pET-His-beta3/BL21(DE3)plysS was a suitable expression system for beta3, and the expressed beta3 specially inhibited the adhesion of cancer cells. Histidine 24-27 eukaryotic translation elongation factor 1 beta 2 pseudogene 2 Homo sapiens 86-91 16176092-10 2005 This suggested that pET-His-beta3/BL21(DE3)plysS was a suitable expression system for beta3, and the expressed beta3 specially inhibited the adhesion of cancer cells. Histidine 24-27 eukaryotic translation elongation factor 1 beta 2 pseudogene 2 Homo sapiens 86-91 16008726-5 2005 Furthermore, serum deprivation-induced apoptosis in a keloid fibroblast line was blocked by a caspase-9 inhibitor (acetyl-Leu-Glu-His-Asp-al), indicating that activation of caspase-9 was necessary for the process of apoptosis in keloid fibroblasts. Histidine 130-133 caspase 9 Homo sapiens 94-103 16008726-5 2005 Furthermore, serum deprivation-induced apoptosis in a keloid fibroblast line was blocked by a caspase-9 inhibitor (acetyl-Leu-Glu-His-Asp-al), indicating that activation of caspase-9 was necessary for the process of apoptosis in keloid fibroblasts. Histidine 130-133 caspase 9 Homo sapiens 173-182 15952772-6 2005 The implication of His 33 and Glu 104 in the binding site was deduced from the comparison of FTIR data recorded with horse heart and the variant tuna cytochrome c lacking these two amino acids. Histidine 19-22 cytochrome c, somatic Equus caballus 150-162 15952772-7 2005 A two-dimensional NMR analysis of the Zn(2+)-binding site in horse heart cytochrome c confirmed that His 33 and residues close to the C terminus are sensitive to Zn(2+) binding. Histidine 101-104 cytochrome c, somatic Equus caballus 73-85 15920280-4 2005 To overcome this problem we attached a signal sequence, as well as an amino-terminal His-tag fusion to the GM-CSF gene. Histidine 85-88 colony stimulating factor 2 Homo sapiens 107-113 15792953-4 2005 Recombinant GcpE protein was purified by an N-terminal His(6) tag and reconstituted as a [4Fe-4S](2+) metalloprotein. Histidine 55-58 ispG Thermosynechococcus elongatus BP-1 12-16 15744050-6 2005 Finally, we revisit the histidine auxotrophy of ade3 or ade16 ade17 mutants. Histidine 24-33 trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase ADE3 Saccharomyces cerevisiae S288C 48-52 15744050-7 2005 Interestingly, overexpression of PMU1, encoding a potential phosphomutase, partially suppresses the histidine requirement of an ade3 ade16 ade17 triple mutant, most probably by reducing the level of AICAR in this mutant. Histidine 100-109 trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase ADE3 Saccharomyces cerevisiae S288C 128-132 15858043-2 2005 Among these residues, aspartate 92 and histidine 117 are both required for Fv1(b) resistance, whereas the latter is sufficient to confer Ref1 resistance. Histidine 39-48 Friend virus susceptibility 1 Mus musculus 75-78 16849170-3 2005 His-26 and His-33 are both solvent exposed, and the results suggest that one of these histidine residues acts as a bridge in the electron transfer to and from the haem iron of cytochrome c. Histidine 0-3 cytochrome c, somatic Equus caballus 176-188 9200711-1 1997 Histidine-235 of human 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) lyase is the second basic residue in a conserved HXH motif. Histidine 0-9 3-hydroxy-3-methylglutaryl-CoA lyase Homo sapiens 23-69 9196036-2 1997 Using histidine-tagged TBP for affinity-purification of TBP-bound proteins, we isolated a 49-kD protein termed TBP-interacting protein 49 (TIP49) from rat liver nuclear extracts. Histidine 6-15 TATA box binding protein Rattus norvegicus 23-26 9196036-2 1997 Using histidine-tagged TBP for affinity-purification of TBP-bound proteins, we isolated a 49-kD protein termed TBP-interacting protein 49 (TIP49) from rat liver nuclear extracts. Histidine 6-15 TATA box binding protein Rattus norvegicus 56-59 9196036-2 1997 Using histidine-tagged TBP for affinity-purification of TBP-bound proteins, we isolated a 49-kD protein termed TBP-interacting protein 49 (TIP49) from rat liver nuclear extracts. Histidine 6-15 TATA box binding protein Rattus norvegicus 56-59 9166854-7 1997 In a Northern blot analysis from homogeneous tissue biopsy from the intradermal injection sites, RANTES was more potent than MCP-1 in increasing histidine decarboxylase (HDC) mRNA, the sole enzyme responsible for the production of histamine from histidine. Histidine 145-154 C-C motif chemokine ligand 2 Rattus norvegicus 125-130 9232197-0 1997 Histidine modification of human serum butyrylcholinesterase. Histidine 0-9 butyrylcholinesterase Homo sapiens 38-59 9232197-12 1997 The results indicate that DPC modifies some essential histidine side chains in BChE, including the functional histidyl residue found at the active site. Histidine 54-63 butyrylcholinesterase Homo sapiens 79-83 9162080-9 1997 Within the catalytic domain, the essential Asp, His, and Ser residues that conform the catalytic triad of this family of proteases are conserved in P69B. Histidine 48-51 subtilisin-like protease Solanum lycopersicum 148-152 16849170-3 2005 His-26 and His-33 are both solvent exposed, and the results suggest that one of these histidine residues acts as a bridge in the electron transfer to and from the haem iron of cytochrome c. Histidine 11-14 cytochrome c, somatic Equus caballus 176-188 16849170-3 2005 His-26 and His-33 are both solvent exposed, and the results suggest that one of these histidine residues acts as a bridge in the electron transfer to and from the haem iron of cytochrome c. Histidine 86-95 cytochrome c, somatic Equus caballus 176-188 15829403-5 2005 The B13 S15.4 peptide-specific CD4+ T-cell clone 3E5 was tested in proliferation assays against 15 Lys/His-substituted S15.4-derived peptides for TCR/HLA contact analysis. Histidine 103-106 NADH:ubiquinone oxidoreductase subunit A5 Homo sapiens 4-7 9153214-8 1997 The conserved site altered by the suppressor mutations appears to be important; his4 HIP1-293 cells show an increased requirement for histidine compared with his4 HIP1 cells. Histidine 134-143 histidine permease Saccharomyces cerevisiae S288C 85-89 9171884-5 1997 The peptide Ac-Nle-c[Asp-His-Phe-Arg-D-Trp9-Ala-Lys]-NH2 demonstrated the greatest differentiation in binding affinity between the hMC1R and hMC4R (78-fold). Histidine 25-28 melanocortin 1 receptor Homo sapiens 131-146 9180374-0 1997 A histidine variant of yeast iso-1-cytochrome c that strongly affects the energetics of the denatured state. Histidine 2-11 threonine ammonia-lyase ILV1 Saccharomyces cerevisiae S288C 29-34 9180374-1 1997 Iso-1-cytochrome c has been engineered to remove all histidine residues not involved in heme ligation in the native state to produce a variant designated TM. Histidine 53-62 threonine ammonia-lyase ILV1 Saccharomyces cerevisiae S288C 0-5 15684398-3 2005 CPSF-73 contains a zinc-binding histidine motif involved in catalysis in other members of the beta-lactamase superfamily, whereas CPSF-100 has substitutions within the histidine motif and thus is unlikely to be catalytically active. Histidine 168-177 cleavage and polyadenylation specific factor 2 Homo sapiens 130-138 15642354-2 2005 LZT subfamily sequences all contain a unique and highly conserved metalloprotease motif (HEXPHEXGD) in transmembrane domain V with both histidine residues essential for zinc transport by ZIP (Zrt-, Irt-like Proteins) transporters. Histidine 136-145 zinc finger CCCH-type and G-patch domain containing Homo sapiens 187-190 15724202-1 2005 The electron transfer reaction of wild-type myoglobin at an electrode was significantly facilitated in a D2O buffer as compared with that in an H2O buffer, with k(0)"(H2O)/k(0)"(D2O)= 0.13, while a minimal deuterium kinetic isotope effect on the myoglobin with modification at distal histidine (His-64) was observed. Histidine 284-293 myoglobin Homo sapiens 44-53 15659125-0 2005 Pharmacokinetics of His-tag recombinant human endostatin in Rhesus monkeys. Histidine 20-23 collagen type XVIII alpha 1 chain Homo sapiens 46-56 15659125-1 2005 AIM: To study the pharmacokinetics and accumulation of an Escherichia coli expressed His-tag fused recombinant human endostatin (rh-endostatin) in Rhesus monkeys. Histidine 85-88 collagen type XVIII alpha 1 chain Homo sapiens 117-127 15659125-1 2005 AIM: To study the pharmacokinetics and accumulation of an Escherichia coli expressed His-tag fused recombinant human endostatin (rh-endostatin) in Rhesus monkeys. Histidine 85-88 collagen type XVIII alpha 1 chain Homo sapiens 132-142 15668489-3 2005 Nonsynonymous variants of EPHX1 at Tyr(113)His (exon 3) and His(139)Arg (exon 4) are associated, respectively, with low ((113)His) and high ((139)Arg) predicted activity. Histidine 43-46 epoxide hydrolase 1 Homo sapiens 26-31 15666128-7 2005 Caspase-3 inhibitor (Ac-Asp-Glu-Val-Asp-CHO) and caspase-9 inhibitor (Ac-Leu-Glu-His-Asp-CHO) completely inhibited this DNA fragmentation. Histidine 81-84 caspase 9 Homo sapiens 49-58 15339918-6 2004 These findings suggest that His(320) is located in the distal heme pocket of OxdA and would donate a proton to the substrate in the aldoxime dehydration mechanism. Histidine 28-31 D-amino acid oxidase Homo sapiens 77-81 15518569-5 2004 Mutation of His42 (the only His of SOUL) to Ala resulted in loss of heme binding, confirming that this residue is an axial ligand of SOUL. Histidine 12-15 heme binding protein 2 Mus musculus 35-39 15518569-5 2004 Mutation of His42 (the only His of SOUL) to Ala resulted in loss of heme binding, confirming that this residue is an axial ligand of SOUL. Histidine 12-15 heme binding protein 2 Mus musculus 133-137 9147644-1 1997 We have generated polyclonal antibodies against the amino-terminal third of the Menkes protein (ATP7A; MNK) by immunizing rabbits with a histidine-tagged MNK fusion construct containing metal-binding domains 1-4. Histidine 137-146 copper-transporting ATPase 1 Oryctolagus cuniculus 96-101 9036967-6 1997 Thus, in addition to the previously defined role of 1253 in the FcRn-IgG interaction, these histidines play a key role in mediating the functions conducted by this Fc receptor. Histidine 92-102 Fc receptor Mus musculus 164-175 9184002-3 1997 The patient had a G to A transition at codon 156 of the keratin K10 gene, which resulted in an arginine (Arg)-->histidine (His) substitution in the helix initiation peptide of the highly-conserved 1A domain in keratin K10. Histidine 115-124 keratin 10 Homo sapiens 64-67 9184002-3 1997 The patient had a G to A transition at codon 156 of the keratin K10 gene, which resulted in an arginine (Arg)-->histidine (His) substitution in the helix initiation peptide of the highly-conserved 1A domain in keratin K10. Histidine 126-129 keratin 10 Homo sapiens 64-67 9184002-3 1997 The patient had a G to A transition at codon 156 of the keratin K10 gene, which resulted in an arginine (Arg)-->histidine (His) substitution in the helix initiation peptide of the highly-conserved 1A domain in keratin K10. Histidine 126-129 keratin 10 Homo sapiens 221-224 9073574-6 1997 As an example of such an approach, singlet oxygen has been implicated in the UVA radiation activation of HO-1 because the activation is enhanced by deuterium oxide (which enhances singlet oxygen lifetime) and suppressed by histidine (which scavenges the species). Histidine 223-232 heme oxygenase 1 Homo sapiens 105-109 9164465-0 1997 Crystal structures of HINT demonstrate that histidine triad proteins are GalT-related nucleotide-binding proteins. Histidine 44-53 adenosine 5'-monophosphoramidase HINT1 Oryctolagus cuniculus 22-26 9164465-1 1997 Histidine triad nucleotide-binding protein (HINT), a dimeric purine nucleotide-binding protein from rabbit heart, is a member of the HIT (histidine triad) superfamily which includes HINT homologues and FHIT (HIT protein encoded at the chromosome 3 fragile site) homologues. Histidine 138-147 adenosine 5'-monophosphoramidase HINT1 Oryctolagus cuniculus 0-42 9164465-1 1997 Histidine triad nucleotide-binding protein (HINT), a dimeric purine nucleotide-binding protein from rabbit heart, is a member of the HIT (histidine triad) superfamily which includes HINT homologues and FHIT (HIT protein encoded at the chromosome 3 fragile site) homologues. Histidine 138-147 adenosine 5'-monophosphoramidase HINT1 Oryctolagus cuniculus 44-48 9164465-1 1997 Histidine triad nucleotide-binding protein (HINT), a dimeric purine nucleotide-binding protein from rabbit heart, is a member of the HIT (histidine triad) superfamily which includes HINT homologues and FHIT (HIT protein encoded at the chromosome 3 fragile site) homologues. Histidine 138-147 adenosine 5'-monophosphoramidase HINT1 Oryctolagus cuniculus 182-186 15648971-0 2004 Do alkylating agents modify the histidine residue of the desensitized butyrylcholinesterase? Histidine 32-41 butyrylcholinesterase Homo sapiens 70-91 15648971-2 2004 The effects of TPCK and TLCK on the histidine in the catalytic triad of the desensitized butyrylcholinesterase (BChE), prepared from human serum by heating at 45 degrees C for 24 h, were investigated in detail. Histidine 36-45 butyrylcholinesterase Homo sapiens 89-110 15648971-2 2004 The effects of TPCK and TLCK on the histidine in the catalytic triad of the desensitized butyrylcholinesterase (BChE), prepared from human serum by heating at 45 degrees C for 24 h, were investigated in detail. Histidine 36-45 butyrylcholinesterase Homo sapiens 112-116 15648974-0 2004 Kinetics of histidine dissociation from the heme Fe(III) in N-fragment (residues 1-56) of cytochrome c. Histidine 12-21 cytochrome c, somatic Equus caballus 90-102 15453723-2 2004 Our new artificial acylase, tert-butyldiphenylsilyl ether of N-(2,4,6-triisopropylbenzenesulfonyl)-pi(Me)-l-histidinol, is a simple and small molecule (molecular weight = 660) that contains only one chiral carbon center that originates from natural l-histidine. Histidine 249-260 telomerase reverse transcriptase Homo sapiens 28-32 15454439-9 2004 Mutation of an extracellular histidine residue, H508, that mediates the inhibitory effect of protons on Kv1.4 current, abolished both K+ activation and the enhancement of K+ activation at acidic pH. Histidine 29-38 potassium voltage-gated channel subfamily A member 4 Homo sapiens 104-109 9037006-5 1997 RNA-dependent phosphorylation was observed both for a histidine-tagged recombinant human C1 hnRNP protein added to nuclear extracts and also for the endogenous C1 hnRNP protein. Histidine 54-63 heterogeneous nuclear ribonucleoprotein C Homo sapiens 92-97 9016645-6 1997 A recombinant histidine-tagged Reb1 protein bearing the rDNA binding domain has two homologous, sequence-specific binding sites in the S. pomber DNA intergenic spacer, located between 289 and 480 nt downstream of the end of the approximately 25S rRNA coding sequences. Histidine 14-23 DNA-binding protein REB1 Saccharomyces cerevisiae S288C 31-35 9042366-4 1997 FucT-VI activity was found to be particularly sensitive to the histidine-selective reagent diethylpyrocarbonate and the cysteine reagent N-ethylmaleimide, with IC50 values of less than 200 microM. Histidine 63-72 fucosyltransferase 6 Homo sapiens 0-7 9042366-8 1997 These data suggest that in addition to an NEM-reactive cysteine in, or adjacent to, the substrate-binding site of the enzyme, FucT-VI possesses histidine residue(s) that are essential for enzyme activity. Histidine 144-153 fucosyltransferase 6 Homo sapiens 126-133 9063899-9 1997 The distinct structural feature of this archaeal ferredoxin lies in the zinc-binding center where the zinc ion is tetrahedrally ligated by four amino acid residues (His 16, His 19, and His 34 from the N-terminal extension, and Asp 76 from the core fold). Histidine 165-168 4Fe-4S binding protein Sulfurisphaera tokodaii str. 7 49-59 15358373-0 2004 Expression and purification of His-tagged rat mitochondrial medium-chain acyl-CoA dehydrogenase wild-type and Arg256 mutant proteins. Histidine 31-34 acyl-CoA dehydrogenase medium chain Rattus norvegicus 60-95 15358373-2 2004 We cloned the gene of rat mitochondrial medium-chain acyl-CoA dehydrogenase into a bacterial expression vector pLM1 with six continuous histidine codons attached to the 3" of the gene. Histidine 136-145 acyl-CoA dehydrogenase medium chain Rattus norvegicus 40-75 15302581-1 2004 As part of a study to identify novel transcriptional regulators of chondrogenesis-related gene expression, we have cloned and characterized cDNA for zinc-finger protein 470 (ZNF470), the human ortholog of which encodes a 717 amino acid residue protein containing 17 Cys(2)His(2) zinc-finger domains, as well as KRAB-A and KRAB-B motifs. Histidine 272-275 zinc finger protein 470 Homo sapiens 149-172 15302581-1 2004 As part of a study to identify novel transcriptional regulators of chondrogenesis-related gene expression, we have cloned and characterized cDNA for zinc-finger protein 470 (ZNF470), the human ortholog of which encodes a 717 amino acid residue protein containing 17 Cys(2)His(2) zinc-finger domains, as well as KRAB-A and KRAB-B motifs. Histidine 272-275 zinc finger protein 470 Homo sapiens 174-180 15218029-4 2004 Pam16 forms a complex with Pam18 and displays similarity to J-proteins but lacks the canonical tripeptide motif His-Pro-Asp (HPD). Histidine 112-115 presequence translocase associated motor 16 Homo sapiens 0-5 15236690-0 2004 Chromatographic purification of an insoluble histidine tag recombinant Ykt6p SNARE from Arabidopsis thaliana over-expressed in E. coli. Histidine 45-54 palmitoyltransferase YKT6 Saccharomyces cerevisiae S288C 71-76 9015380-5 1997 A yeast strain was created in which the essential 64-kDa glycoprotein Nlt1p subunit of the oligosaccharyl transferase was modified by the addition of a 22-residue carboxy-terminal affinity tag; the tag included both an 8-residue FLAG epitope and a 6-residue histidine motif. Histidine 258-267 dolichyl-diphosphooligosaccharide--protein glycotransferase subunit OST1 Saccharomyces cerevisiae S288C 70-75 8961924-1 1996 Rat spermatidal protein TP2 is a zinc metalloprotein with two atoms of zinc coordinated to cysteine and histidine residues and condenses alternating GC copolymer preferentially in a zinc dependent manner [Kundu, T. K., & Rao, M. R. S. (1995) Biochemistry 34,5143-5150]. Histidine 104-113 transition protein 2 Homo sapiens 24-27 8962082-12 1996 Both the MBP and the thioredoxin-His-tags do not appear to interfere with the catalytic activity of human FAS or its partial activities. Histidine 33-36 thioredoxin Homo sapiens 21-32 8962099-5 1996 mCPEB shows 80% overall identity with its Xenopus counterpart, with a higher homology in the carboxyl-terminal portion, which contains two RNA recognition motifs and a cysteine/histidine repeat. Histidine 177-186 cytoplasmic polyadenylation element binding protein 1 Mus musculus 0-5 15265741-3 2004 To identify novel Hsp90 inhibitors, a highly robust time-resolved fluorescence resonance energy transfer (TR-FRET)-based HTS assay that measures the binding of biotinylated geldanamycin (biotin-GM) to the His-tagged human Hsp90 N-terminal ATP-binding domain (Hsp90N) was developed. Histidine 205-208 heat shock protein 90 alpha family class A member 1 Homo sapiens 18-23 15225714-0 2004 Analogs of sub-nanomolar hMC1R agonist LK-184 [Ph(CH2)3CO-His-D-Phe-Arg-Trp-NH2]. Histidine 58-61 melanocortin 1 receptor Homo sapiens 25-30 15225714-6 2004 This suggests the existence of an additional binding site within hMC1R next to that for the core sequence His-d-Phe-Arg-Trp-NH(2). Histidine 106-109 melanocortin 1 receptor Homo sapiens 65-70 15265919-0 2004 Histidines are critical for heparin-dependent activation of mast cell tryptase. Histidine 0-10 tryptase alpha/beta 1 Mus musculus 70-78 15265919-10 2004 Taken together, this study shows that surface-exposed histidines mediate the interaction of mast cell tryptase with heparin and are of critical importance in the formation of active tryptase tetramers. Histidine 54-64 tryptase alpha/beta 1 Mus musculus 102-110 15265919-10 2004 Taken together, this study shows that surface-exposed histidines mediate the interaction of mast cell tryptase with heparin and are of critical importance in the formation of active tryptase tetramers. Histidine 54-64 tryptase alpha/beta 1 Mus musculus 182-190 15161915-10 2004 Based on the NK1 domain structure, we propose that copper(II) may interact with HGF via the histidine residues in either N-terminal or kringle domains. Histidine 92-101 tachykinin receptor 1 Homo sapiens 13-16 15260978-6 2004 The PDE1B structure shows that in dual-specific PDEs a key histidine residue may enable the invariant glutamine to toggle between cAMP and cGMP. Histidine 59-68 phosphodiesterase 1B Homo sapiens 4-9 9010776-7 1996 We isolated a candidate cDNA for ABP-2, and the protein it encoded contained nine Zn fingers and regions rich in alanine, glutamine, serine/threonine, glycine, histidine, and asparagine. Histidine 160-169 lava lamp Drosophila melanogaster 33-38 8995843-0 1996 HCN, a triple-resonance NMR technique for selective observation of histidine and tryptophan side chains in 13C/15N-labeled proteins. Histidine 67-76 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 0-3 8995843-1 1996 HCN, a new 3D NMR technique for stepwise coherence transfer from 1H to 13C to 15N and reverse through direct spin couplings 1JCH and 1JCN, is presented as a method for detection and assignment of histidine and tryptophan side-chain 1H, 13C, and 15N resonances in uniformly 13C/15N-labeled proteins. Histidine 196-205 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 0-3 9050160-1 1996 113Cd NMR spectroscopy in both the solution and solid state has been used to investigate the role of the metal ion and the proximal histidine on metalloporphyrin reorientation in myoglobin. Histidine 132-141 myoglobin Homo sapiens 179-188 8942679-0 1996 Active site structure in cytochrome c peroxidase and myoglobin mutants: effects of altered hydrogen bonding to the proximal histidine. Histidine 124-133 myoglobin Homo sapiens 53-62 8931561-3 1996 Peptide mapping of the reaction products by mass spectrometry showed that, with low DEP:M-CSF ratios (< 50:1), there was selective modification of histidine residues, whereas at higher ratios (> 50:1), Tyr and Lys residues were also modified. Histidine 150-159 colony stimulating factor 1 Homo sapiens 88-93 15238222-2 2004 We have isolated a cDNA encoding an isoform of CCT from Drosophila melanogaster and expressed the recombinant native and 6 x -His-tagged forms using a baculovirus expression system in Spodoptera frugiperda (Sf9) insect cells. Histidine 126-129 Phosphocholine cytidylyltransferase 1 Drosophila melanogaster 47-50 15206929-2 2004 The cDNA encoding a C-terminally histidine-tagged (10xHis) human histamine H1 receptor was used to generate recombinant baculovirus in a Spodoptera frugiperda-derived cell line (IPLB-Sf9). Histidine 33-42 histamine receptor H1 Homo sapiens 65-86 15177288-5 2004 In this study, we have cloned, overexpressed, and characterized the entire coding region and the cytoplasmic domain of PknI as a fusion protein with an N-terminal histidine tag, and used immobilized metal affinity chromatography for purification of recombinant proteins. Histidine 163-172 serine/threonine-protein kinase PknI Mycobacterium tuberculosis H37Rv 119-123 15178418-4 2004 To further investigate the drugs metabolized by UGT1A4, the Bac-to-Bac expression system was used to express the recombinant UGT1A4 with His-tag on the C-terminal. Histidine 137-140 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 48-54 15178418-4 2004 To further investigate the drugs metabolized by UGT1A4, the Bac-to-Bac expression system was used to express the recombinant UGT1A4 with His-tag on the C-terminal. Histidine 137-140 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 125-131 15194871-5 2004 We found that mutation of leucine 958, leucine 973 or histidine 974 or deletion of a spacer sequence of more than six amino acids between leucine 958 and histidine 974 disrupted the NR3A/PP2A interaction. Histidine 54-63 glutamate ionotropic receptor NMDA type subunit 3A Homo sapiens 182-186 15194871-5 2004 We found that mutation of leucine 958, leucine 973 or histidine 974 or deletion of a spacer sequence of more than six amino acids between leucine 958 and histidine 974 disrupted the NR3A/PP2A interaction. Histidine 154-163 glutamate ionotropic receptor NMDA type subunit 3A Homo sapiens 182-186 15194871-5 2004 We found that mutation of leucine 958, leucine 973 or histidine 974 or deletion of a spacer sequence of more than six amino acids between leucine 958 and histidine 974 disrupted the NR3A/PP2A interaction. Histidine 154-163 protein phosphatase 2 phosphatase activator Homo sapiens 187-191 15218992-7 2004 During combined analysis of genetic polymorphisms for mEPHX, GSTM1 and GSTP1, it was found that there are strong indicators for susceptibility to COPD (genotype combination with at least one mutant mEPHX exon-3 allele (histidine 113), GSTM1 null and homozygous for the GSTPI isoleucine 105 allele). Histidine 219-228 glutathione S-transferase pi 1 Homo sapiens 71-76 15149817-3 2004 Folding of cyt c leads to a state having the heme iron coordinated to a histidine (His18) and a methionine (Met80) as axial ligands. Histidine 72-81 cytochrome c, somatic Equus caballus 11-16 15144374-4 2004 Here, we show that the N-terminal conserved motif (EFWG) and histidine 25 (H25), a potential catalytic residue, were important for the gene repression activity of HD2A. Histidine 61-70 histone deacetylase 3 Arabidopsis thaliana 163-167 8937558-5 1996 In this enzyme, autophosphorylation of active site histidine is an accepted intermediate step in the catalytic phosphate transfer activity of nucleoside diphosphate kinase (NDP kinase). Histidine 51-60 cytidine/uridine monophosphate kinase 2 Homo sapiens 142-171 8937558-5 1996 In this enzyme, autophosphorylation of active site histidine is an accepted intermediate step in the catalytic phosphate transfer activity of nucleoside diphosphate kinase (NDP kinase). Histidine 51-60 cytidine/uridine monophosphate kinase 2 Homo sapiens 173-183 15123430-1 2004 Production of seven single surface histidine variants of yeast iso-1-cytochrome c allowed measurement of the apparent pK(a), pK(a)(obs), for histidine-heme loop formation for loops of nine to 83 amino acid residues under varying denaturing conditions (2 M to 6 M guanidine hydrochloride, gdnHCl). Histidine 35-44 threonine ammonia-lyase ILV1 Saccharomyces cerevisiae S288C 63-68 8917449-4 1996 This fusion protein has a deduced molecular mass of 65980 Da and is formed by fusion of the first 389 amino acids of diphtheria toxin to amino acids 2-184 of mature human LIF, using a linker of 34 amino acids that includes six consecutive histidine residues. Histidine 239-248 LIF interleukin 6 family cytokine Homo sapiens 171-174 8810323-7 1996 Greater than two-thirds of GRP-1 are only two amino acids, namely glutamine (50%) and histidine (18%). Histidine 86-95 glutamine repeat protein 1 Mus musculus 27-32 15078916-9 2004 Alkaline pH increased the water permeability of AQP4 that contains His at position 129 in loop C. Acid and alkaline pH sensitivity was induced in AQP1 by adding histidines 48 (in loop A) and 130 (in loop C). Histidine 67-70 aquaporin 4 Bos taurus 48-52 15078916-9 2004 Alkaline pH increased the water permeability of AQP4 that contains His at position 129 in loop C. Acid and alkaline pH sensitivity was induced in AQP1 by adding histidines 48 (in loop A) and 130 (in loop C). Histidine 161-171 aquaporin 4 Bos taurus 48-52 14982931-1 2004 Hint, histidine triad nucleotide-binding protein, is a universally conserved enzyme that hydrolyzes AMP linked to lysine and, in yeast, functions as a positive regulator of the RNA polymerase II C-terminal domain kinase, Kin28. Histidine 6-15 adenosine 5'-monophosphoramidase HINT1 Oryctolagus cuniculus 0-4 14982931-1 2004 Hint, histidine triad nucleotide-binding protein, is a universally conserved enzyme that hydrolyzes AMP linked to lysine and, in yeast, functions as a positive regulator of the RNA polymerase II C-terminal domain kinase, Kin28. Histidine 6-15 TFIIH complex serine/threonine-protein kinase subunit KIN28 Saccharomyces cerevisiae S288C 221-226 15063568-2 2004 Recombinant histidine-tagged SafB chaperone complexed with SafD adhesin was expressed in Escherichia coli and purified. Histidine 12-21 scaffold attachment factor B Mus musculus 29-33 8855949-1 1996 We have reported that H93C human myoglobin (Mb), in which proximal histidine (His93, F8) was replaced by cysteine, gave nearly identical spectroscopic features of P-450 [Adachi, S., Nagano, S., Ishimori, K., Watanabe, Y., Morishima, I., Egawa, T., Kitagawa, T., & Makino R. (1993) Biochemistry 32, 241-252]. Histidine 67-76 myoglobin Homo sapiens 33-42 8798701-5 1996 Diethyl pyrocarbonate modification of His-4 and His-8 in the H75A/H84Q double mutant abolished neuritogenesis, binding to both receptors, and phosphorylation of p140(trkA) in PC12 cells. Histidine 38-41 SRC kinase signaling inhibitor 1 Rattus norvegicus 161-165 8798701-5 1996 Diethyl pyrocarbonate modification of His-4 and His-8 in the H75A/H84Q double mutant abolished neuritogenesis, binding to both receptors, and phosphorylation of p140(trkA) in PC12 cells. Histidine 48-51 SRC kinase signaling inhibitor 1 Rattus norvegicus 161-165 8760503-8 1996 (1) A highly conserved histidine residue in the first complementarity-determining region of the TcR beta chain (beta:CDR1) points outward and interacts with highly conserved side-chains on the MHC alpha 2 helix. Histidine 23-32 T cell receptor alpha variable 6-3 Mus musculus 96-99 8863155-1 1996 In five different Japanese families, we identified six male hemizygotes (aged 6, 9, 15, 17, 56, and 65 years) and a putative candidate (aged 48 years), carrying a mutant allele of the ornithine transcarbamylase (OTC) gene, a G to A substitution at nucleotide 119 in exon 2 generating histidine in place of arginine. Histidine 284-293 ornithine transcarbamylase Homo sapiens 212-215 8760919-1 1996 The Rhodobacter sphaeroides 2.4.1 hisI gene, which encodes a phosphoribosyl-AMP-cyclohydrolase that catalyses the third step in the histidine biosynthetic pathway, has been isolated from a genomic library of this phototrophic bacterium by complementation of an Escherichia coli hisI mutant. Histidine 132-141 phosphoribosyl-AMP cyclohydrolase Rhodobacter sphaeroides 2.4.1 34-38 8760919-1 1996 The Rhodobacter sphaeroides 2.4.1 hisI gene, which encodes a phosphoribosyl-AMP-cyclohydrolase that catalyses the third step in the histidine biosynthetic pathway, has been isolated from a genomic library of this phototrophic bacterium by complementation of an Escherichia coli hisI mutant. Histidine 132-141 phosphoribosyl-AMP cyclohydrolase Rhodobacter sphaeroides 2.4.1 278-282 8844860-9 1996 Thus, the effects on TCR binding of the His 135 residue could actually be mediated, wholly or in part, by the alpha 1 helix. Histidine 40-43 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 21-24 8663386-4 1996 Lysines are the only residues to be engaged in the dimerization with human retinoid X receptor alpha (hRXRalpha) in the absence of DNA, whereas histidines are selectively involved in the homodimerization of hRARalpha in the presence of a RARE. Histidine 144-154 retinoic acid receptor alpha Homo sapiens 207-216 15001397-4 2004 When cells expressing the recombinant TPI protein with histidine tag were exposed to hypoxia and the TPI protein was affinity-purified, the catalytic activity (specific activity) of the TPI protein purified from hypoxic cells was substantially lower than that obtained from normoxic cells. Histidine 55-64 triosephosphate isomerase 1 Mus musculus 38-41 15025965-0 2004 [Abnormal expression of fragile histidine triad (FHIT) and Mut S homolog 2 (MSH2) proteins in human sporadic colorectal carcinoma and their clinical significance]. Histidine 32-41 serpin family B member 3 Homo sapiens 100-129 15012592-0 2004 N-terminal His(7)-modification of glucagon-like peptide-1(7-36) amide generates dipeptidyl peptidase IV-stable analogues with potent antihyperglycaemic activity. Histidine 11-14 dipeptidyl peptidase 4 Homo sapiens 80-103 15049834-5 2004 The Thz ring, protecting both the amino and thiol groups in Nin-Cys, completely avoids the formylation and Thz side reactions found during hydrofluoric acid (HF) cleavage when N-pi-benzyloxymethyl histidine groups are present. Histidine 197-206 ninein Homo sapiens 60-63 15026177-11 2004 In addition to characterizing catalytic residues, these studies have identified the structural basis (His(156)) for an exploitable difference in the substrate and inhibition kinetics of 3 beta-HSD1 and 3 beta-HSD2. Histidine 102-105 hydroxysteroid 11-beta dehydrogenase 2 Homo sapiens 186-213 14769043-2 2004 The two thioether bonds linking protein to heme in cyt c are present in 1, and the native axial ligand His-18 remains coordinated to iron. Histidine 103-106 cytochrome c, somatic Equus caballus 51-56 12905028-9 2004 PHT1 and PHT2 were shown to transport free histidine and certain di- and tripeptides, but it is not yet clear whether they are located on the plasma membrane or represent lysosomal transporters for the proton-dependent export of histidine and dipeptides from lysosomal protein degradation into the cytosol. Histidine 43-52 solute carrier family 15 member 4 Homo sapiens 0-4 12905028-9 2004 PHT1 and PHT2 were shown to transport free histidine and certain di- and tripeptides, but it is not yet clear whether they are located on the plasma membrane or represent lysosomal transporters for the proton-dependent export of histidine and dipeptides from lysosomal protein degradation into the cytosol. Histidine 229-238 solute carrier family 15 member 4 Homo sapiens 0-4 14734527-1 2004 The products of the human leukocyte antigen subtypes HLA-B*2705 and HLA-B*2709 differ only in residue 116 (Asp vs. His) within the peptide binding groove but are differentially associated with the autoimmune disease ankylosing spondylitis (AS); HLA-B*2705 occurs in AS-patients, whereas HLA-B*2709 does not. Histidine 115-118 major histocompatibility complex, class I, B Homo sapiens 53-58 14734527-1 2004 The products of the human leukocyte antigen subtypes HLA-B*2705 and HLA-B*2709 differ only in residue 116 (Asp vs. His) within the peptide binding groove but are differentially associated with the autoimmune disease ankylosing spondylitis (AS); HLA-B*2705 occurs in AS-patients, whereas HLA-B*2709 does not. Histidine 115-118 major histocompatibility complex, class I, B Homo sapiens 68-73 14734527-1 2004 The products of the human leukocyte antigen subtypes HLA-B*2705 and HLA-B*2709 differ only in residue 116 (Asp vs. His) within the peptide binding groove but are differentially associated with the autoimmune disease ankylosing spondylitis (AS); HLA-B*2705 occurs in AS-patients, whereas HLA-B*2709 does not. Histidine 115-118 major histocompatibility complex, class I, B Homo sapiens 68-73 14734527-1 2004 The products of the human leukocyte antigen subtypes HLA-B*2705 and HLA-B*2709 differ only in residue 116 (Asp vs. His) within the peptide binding groove but are differentially associated with the autoimmune disease ankylosing spondylitis (AS); HLA-B*2705 occurs in AS-patients, whereas HLA-B*2709 does not. Histidine 115-118 major histocompatibility complex, class I, B Homo sapiens 68-73 15471342-4 2004 One surprising result, which will be stressed in the discussion, is the observation of a distinct product state vibrational coherence (the iron-histidine stretching vibration of deoxy Mb at 220 cm(-1)) that depends upon the presence of pump field interactions having a wavelength mismatch that is equal to the 220 cm(-1) vibrational frequency. Histidine 144-153 myoglobin Homo sapiens 184-186 8755573-3 1996 FGFR2/Neu chimeras were generated by substituting the extracellular domain of Neu with that of FGFR2 containing the following Crouzon mutations: Tyr-340-->His; Cys-342-->Tyr; Cys-342-->Arg; Cys-342-->Ser; Ser-354-->Cys: and delta17 (deletion of amino acids 345-361). Histidine 158-161 fibroblast growth factor receptor 2 Homo sapiens 0-5 8694771-16 1996 The (beta 1-3)GalT activity was also inhibited by diethyl pyrocarbonate, but not by N-ethylmaleimide or iodoacetamide, suggesting that active-site histidine residues, rather than cysteine residue(s), are important for enzyme activity. Histidine 147-156 eukaryotic translation elongation factor 1 beta 2 pseudogene 2 Homo sapiens 5-13 14750595-3 2004 Dominant cone-rod dystrophies arising from changes in retGC1 are essentially restricted to mutations in codon 838 and result in the replacement of a conserved arginine residue with either cysteine, histidine or serine. Histidine 198-207 guanylate cyclase 2D, retinal Homo sapiens 54-60 14532275-8 2003 Protein sequence analysis and homology modeling further verified that MMP-26 has an intermediate S1" pocket formed by Leu-204, His-208, and Tyr-230. Histidine 127-130 matrix metallopeptidase 26 Homo sapiens 70-76 14532275-11 2003 MMP-26 contains a His-233 that renders the S1" pocket to an intermediate size. Histidine 18-21 matrix metallopeptidase 26 Homo sapiens 0-6 12959987-4 2003 L-Histidine (L-His) increases the sensitivity of the CaSR to extracellular Ca2+ and potentiates glucose-dependent insulin secretion from INS-1 cells. Histidine 0-11 insulin 1 Rattus norvegicus 137-142 12959987-4 2003 L-Histidine (L-His) increases the sensitivity of the CaSR to extracellular Ca2+ and potentiates glucose-dependent insulin secretion from INS-1 cells. Histidine 0-5 insulin 1 Rattus norvegicus 137-142 12885787-11 2003 Four residues in the first cysteine-bracketed loop of chi-MrIA and a His in loop 2 played a dominant role in the interaction between chi-MrIA and the NET. Histidine 69-72 solute carrier family 6 member 2 Rattus norvegicus 150-153 14519080-8 2003 DAB(389)EGF is a fusion protein composed of the catalytic and translocation domains of diphtheria toxin fused via a His-Ala linker to human epidermal growth factor (EGF). Histidine 116-119 epidermal growth factor Homo sapiens 8-11 12962478-3 2003 Resistin cDNA derived from human subcutaneous adipose tissue was expressed in Escherichia coli as an N-terminal six-His-tag fusion protein. Histidine 116-119 resistin Homo sapiens 0-8 12860998-5 2003 Mutation of histidine residues 19 and 22 to leucine on the p21-binding domain of Pak5 completely abolished the binding of Cdc42 and the Cdc42-mediated autophosphorylation. Histidine 12-21 p21 (RAC1) activated kinase 5 Homo sapiens 81-85 12939145-1 2003 In the elucidation of structural requirements of heme vicinity for hydrogen peroxide activation, we found that the replacement of His-64 of myoglobin (Mb) with a negatively charged aspartate residue enhanced peroxidase and peroxygenase activities by 78- and 580-fold, respectively. Histidine 130-133 myoglobin Homo sapiens 140-149 12944466-7 2003 The interaction involves the I-mfa domain of HIC and the regulatory histidine-rich region of cyclin T1. Histidine 68-77 MyoD family inhibitor domain containing Homo sapiens 45-48 12873485-0 2003 Sub-nanomolar hMC1R agonists by end-capping of the melanocortin tetrapeptide His-D-Phe-Arg-Trp-NH(2). Histidine 77-80 melanocortin 1 receptor Homo sapiens 14-19 12873485-2 2003 The SAR within this series allowed us to map the hMCRs near the His(6) binding site and design a superpotent MC1R agonist, LK-184, Ph(CH(2))(3)CO-His-D-Phe-Arg-Trp-NH(2) (19) with EC(50) 0.01 nM (5 nM at MC3 and MC4Rs). Histidine 64-67 melanocortin 1 receptor Homo sapiens 109-113 12873485-2 2003 The SAR within this series allowed us to map the hMCRs near the His(6) binding site and design a superpotent MC1R agonist, LK-184, Ph(CH(2))(3)CO-His-D-Phe-Arg-Trp-NH(2) (19) with EC(50) 0.01 nM (5 nM at MC3 and MC4Rs). Histidine 146-149 melanocortin 1 receptor Homo sapiens 109-113 12905023-6 2003 Expression of AtGCN2 in yeast gcn2 mutants complemented the mutation, enabling growth in the presence of sulfometuron methyl, an inhibitor of branched-chain amino acid biosynthesis, and 3-aminotriazole, an inhibitor of histidine biosynthesis. Histidine 219-228 protein kinase family protein Arabidopsis thaliana 14-20 8757974-8 1996 VLP collected from sucrose density gradient fractions contained protein which reacted with nickel chelated to nitrilotriacetic acid, a histidine-specific reagent. Histidine 135-144 VHL like Homo sapiens 0-3 12672482-6 2003 The complete amino acid sequence of 157 residues of Theliostyla myoglobin shows that it has a long N-terminal extension of seven residues and contains three functional key residues: CD1-Phe, E7-His, and F8-His. Histidine 194-197 myoglobin Homo sapiens 64-73 8652553-8 1996 The functional importance of Trp-139 is also demonstrated by the finding that its replacement by Phe, His, Pro, or Ala gives mutant enzymes that are optimally active at temperatures below that of the wild-type enzyme and undergo the E-PLP --> E-PMP transition as a function of D-Ala concentration with reduced efficiency. Histidine 102-105 proteolipid protein 1 Homo sapiens 235-238 8573177-0 1996 GTP, a nonsubstrate of ATP citrate lyase, is a phosphodonor for the enzyme histidine autophosphorylation. Histidine 75-84 ATP citrate lyase Homo sapiens 23-40 8769716-4 1996 The case showed CAT at codon 273 instead of wild-type CGT, substituting the encoded amino acid form histidine to arginine. Histidine 100-109 UDP glycosyltransferase 8 Homo sapiens 54-57 8825190-1 1996 The pharmacokinetics of L-histidine in humans has been investigated to evaluate the in vivo histidine ammonia lyase system for the conversion of L-histidine to urocanic acid. Histidine 145-156 histidine ammonia-lyase Homo sapiens 92-115 12672482-6 2003 The complete amino acid sequence of 157 residues of Theliostyla myoglobin shows that it has a long N-terminal extension of seven residues and contains three functional key residues: CD1-Phe, E7-His, and F8-His. Histidine 206-209 myoglobin Homo sapiens 64-73 15969068-2 2003 The cDNA of human leptin with 6 x his-tag was cloned by over-hang extension PCR protocol using human genomic DNA as template, and subcloned into in vitro expression vector pIVEX2.3MCS, and the fusion protein was expressed in vitro by Rapid Translation System (RTS) (RTS500 cycle primer Kit and RTS500 ProteoMaster of Roche company). Histidine 34-37 leptin Homo sapiens 18-24 12771201-0 2003 The phage T4 restriction endoribonuclease RegB: a cyclizing enzyme that requires two histidines to be fully active. Histidine 85-95 site-specific RNA endonuclease Escherichia phage T4 42-46 12771201-5 2003 In order to determine the residues crucial for its activity, we prepared all the histidine-to- alanine point mutants of RegB. Histidine 81-90 site-specific RNA endonuclease Escherichia phage T4 120-124 12837208-4 2003 Yeast cells co-transfected with pAS2-1-PreS1 and the normal human liver cDNA library grew in selective SC/-trp-leu-his-ade2 medium, and the second screening was performed with LacZ report gene. Histidine 115-118 E2 ubiquitin-protein ligase peroxin 4 Saccharomyces cerevisiae S288C 32-36 8811462-1 1996 The extracellular domain of the TSH receptor (TSHR-561, amino acids #78-389) was expressed as a hexa-histidine fusion protein in bacteria. Histidine 101-110 thyroid stimulating hormone receptor Homo sapiens 32-44 8811462-1 1996 The extracellular domain of the TSH receptor (TSHR-561, amino acids #78-389) was expressed as a hexa-histidine fusion protein in bacteria. Histidine 101-110 thyroid stimulating hormone receptor Homo sapiens 46-50 8523543-3 1996 Altered ATRC1 receptors bearing either a phenylalanine, a tryptophan, a histidine, or a methionine at position 235 mediated ecotropic virus entry comparable to that mediated by ATRC1. Histidine 72-81 solute carrier family 7 member 1 Homo sapiens 8-13 8548458-2 1996 The Class I glutamine amidotransferase domain of GMP synthetase is found in related enzymes of the purine, pyrimidine, tryptophan, arginine, histidine and folic acid biosynthetic pathways. Histidine 141-150 guanine monophosphate synthase Homo sapiens 49-63 8537336-5 1995 A close comparison with the human P2Y2 sequence reveals the conservation of histidine 262, arginine 265, lysine 289, and arginine 292, which were reported to be involved in nucleotide binding (Erb, L., Garrad, R., Wang, Y., Quinn, T., Turner, J. T., and Weisman, G. A. Histidine 76-85 purinergic receptor P2Y2 Homo sapiens 34-38 8545129-6 1995 We have since screened for genes in the vicinity of the insertion point and have identified a gene that is equivalent to the murine TIS11d gene, a member of TIS11 early response gene family, that contains unique Cysteine-Histidine motifs. Histidine 221-230 zinc finger protein 36 Mus musculus 132-138 8545129-6 1995 We have since screened for genes in the vicinity of the insertion point and have identified a gene that is equivalent to the murine TIS11d gene, a member of TIS11 early response gene family, that contains unique Cysteine-Histidine motifs. Histidine 221-230 zinc finger protein 36 Mus musculus 132-137 7872792-0 1995 Demonstration that histidine 25, but not 132, is the axial heme ligand in rat heme oxygenase-1. Histidine 19-28 heme oxygenase 1 Rattus norvegicus 78-94 7852403-4 1995 The results suggest that pyridine induces a structural modification in the heme environment of cytochrome b558 by shifting the 5th heme ligand (histidine) to a nearby thiolate group without direct binding of pyridine to the heme. Histidine 144-153 cytochrome b Sus scrofa 95-107 7852330-2 1995 In the present investigation, we targeted Trp and His residues in human serum vitamin D-binding protein (hDBP) by modifying them with specific chemical modifiers. Histidine 50-53 GC vitamin D binding protein Homo sapiens 78-103 7852330-7 1995 These results strongly emphasized the importance of Trp (single residue at position 145) and 1 His residue (out of a total of 6) in the vitamin D sterol-binding by vitamin D-binding protein. Histidine 95-98 GC vitamin D binding protein Homo sapiens 164-189 12570875-3 2003 Binding was restored following urea denaturation, suggesting that Lck/V5-His is in a "closed" conformation in these domains. Histidine 73-76 LCK proto-oncogene, Src family tyrosine kinase Homo sapiens 66-69 12570875-9 2003 Co-immunoprecipitation experiments from Tyr(505) --> Phe/V5-His-expressing cells revealed that LAT preferentially interacts with the "open" form of Lck in T cell raft domains. Histidine 63-66 LCK proto-oncogene, Src family tyrosine kinase Homo sapiens 151-154 12738633-5 2003 The recombinant proteins MOMP and Hsp60 were purified from the bacterial lysate with the aid of the carboxy-terminal histidine hexamer tag by affinity chromatography. Histidine 117-126 heat shock protein 1 (chaperonin) Mus musculus 34-39 12684778-2 2003 Spot-1 interacts with the nuclear localization signal (NLS) I of p53 through its His-Thr domain. Histidine 81-84 transformation related protein 53, pseudogene Mus musculus 65-68 12681501-0 2003 Histidine 454 plays an important role in polymerization of human glutamate dehydrogenase. Histidine 0-9 glutamate dehydrogenase 1 Homo sapiens 65-88 12699701-3 2003 The E1alpha sequence was engineered to include an N-terminal His-tag. Histidine 61-64 pyruvate dehydrogenase complex E1 alpha subunit Arabidopsis thaliana 4-11 12551944-4 2003 Western blot revealed that YggB-His(6) oligomers are more stable in the presence of Ni(2+), providing evidence that Ni(2+) is coordinated between C termini from different subunits of the channel. Histidine 32-35 hypothetical protein Escherichia coli 27-31 12623125-4 2003 Human AhR and Arnt with a C-terminal histidine tag have been expressed functionally using a baculovirus expression system. Histidine 37-46 aryl hydrocarbon receptor nuclear translocator Homo sapiens 14-18 12804117-1 2003 TGFbeta-Inducible Early Gene (TIEG) and the alternatively-transcribed Early Growth Response Gene alpha (EGRalpha) share a Cys(2)His(2) three-zinc finger region with high homology to Sp1 within its zinc finger region. Histidine 128-131 Kruppel like factor 10 Homo sapiens 0-28 12804117-1 2003 TGFbeta-Inducible Early Gene (TIEG) and the alternatively-transcribed Early Growth Response Gene alpha (EGRalpha) share a Cys(2)His(2) three-zinc finger region with high homology to Sp1 within its zinc finger region. Histidine 128-131 Kruppel like factor 10 Homo sapiens 30-34 12540540-4 2003 Immunization of mice with His-tag Cbp or His-tag Csp did not provide effective protection against the lethal activity of His-tag Cpa. Histidine 26-29 phosphoprotein associated with glycosphingolipid microdomains 1 Mus musculus 34-37 12361957-9 2002 Such activation was eliminated when a histidine residue in the M1-H5 linker was mutated to a non-titratable glutamine, i.e. H116Q in GIRK1 and H120Q in GIRK4. Histidine 38-47 potassium inwardly rectifying channel subfamily J member 5 L homeolog Xenopus laevis 152-157 7747623-3 1995 The 48-amino-acid pre-pro-peptide contains the expected hydrophobic leader sequence and the dibasic Lys-Arg sequence preceding the NH2-terminal His of the mature 49-amino-acid chicken osteocalcin, which is believed to be necessary for pro-peptide cleavage. Histidine 144-147 bone gamma-carboxyglutamate protein Gallus gallus 184-195 12531019-8 2002 Pull-down of hOgg1 by histidine-tagged CSB and co-localization of those two proteins after gamma-radiation indicated their co-existence in vivo, particularly under cellular stress. Histidine 22-31 8-oxoguanine DNA glycosylase Homo sapiens 13-18 12419835-10 2002 Selective caspase 9 inhibitor [z-Leu-Glu(OMe)-His-Asp(OMe)-FMK] showed only partial inhibition of GSE-induced apoptosis whereas GSE-induced protease activity of caspase 9 was completely inhibited. Histidine 46-49 caspase 9 Homo sapiens 10-19 12546417-2 2002 ERG25p contains three histidine clusters common to nonheme iron binding enzymes and endoplasmic reticulum retrieval signal. Histidine 22-31 methylsterol monooxygenase Saccharomyces cerevisiae S288C 0-6 7723755-0 1995 [Dynamic mobility of the histidine-containing domain of spin-labeled lysozyme]. Histidine 25-34 spindlin 1 Homo sapiens 56-60 7723755-1 1995 The hen egg-white lysozyme was modified by the spin label (2,2,6,6-tetramethylpiperidine-N1-oxyl-4-iodacetamide) at the single histidine residue His-15. Histidine 127-136 spindlin 1 Homo sapiens 47-51 7723755-1 1995 The hen egg-white lysozyme was modified by the spin label (2,2,6,6-tetramethylpiperidine-N1-oxyl-4-iodacetamide) at the single histidine residue His-15. Histidine 145-148 spindlin 1 Homo sapiens 47-51 7803386-3 1994 The structure of H94C CAII reveals the successful substitution of the naturally occurring histidine zinc ligand by a cysteine thiolate, and metal coordination by C94 is facilitated by the plastic structural response of the beta-sheet superstructure. Histidine 90-99 carbonic anhydrase 2 Homo sapiens 22-26 7969132-9 1994 This GCN2-independent pathway was also stimulated to a lesser extent by the multicopy tRNA(His) constructs in histidine-deprived cells. Histidine 110-119 serine/threonine-protein kinase GCN2 Saccharomyces cerevisiae S288C 5-9 12202490-4 2002 The active site histidines, His-15 of HPr and His-65 of IIA(Mtl), are in close spatial proximity, and a pentacoordinate phosphoryl transition state can be readily accommodated with no change in protein-protein orientation and only minimal perturbations of the backbone immediately adjacent to the histidines. Histidine 16-26 colicin Ia immunity protein Escherichia coli 56-59 12202490-4 2002 The active site histidines, His-15 of HPr and His-65 of IIA(Mtl), are in close spatial proximity, and a pentacoordinate phosphoryl transition state can be readily accommodated with no change in protein-protein orientation and only minimal perturbations of the backbone immediately adjacent to the histidines. Histidine 28-31 colicin Ia immunity protein Escherichia coli 56-59 12202490-4 2002 The active site histidines, His-15 of HPr and His-65 of IIA(Mtl), are in close spatial proximity, and a pentacoordinate phosphoryl transition state can be readily accommodated with no change in protein-protein orientation and only minimal perturbations of the backbone immediately adjacent to the histidines. Histidine 46-49 colicin Ia immunity protein Escherichia coli 56-59 12202490-4 2002 The active site histidines, His-15 of HPr and His-65 of IIA(Mtl), are in close spatial proximity, and a pentacoordinate phosphoryl transition state can be readily accommodated with no change in protein-protein orientation and only minimal perturbations of the backbone immediately adjacent to the histidines. Histidine 297-307 colicin Ia immunity protein Escherichia coli 56-59 12193598-6 2002 The Erf2p/Erf4p complex is required for Ras PAT activity, and mutations within conserved residues (Cys(189), His(201), and Cys(203)) of the Erf2p DHHC-CRD domain abolish Ras PAT activity. Histidine 109-112 palmitoyltransferase ERF2 Saccharomyces cerevisiae S288C 4-9 12193598-6 2002 The Erf2p/Erf4p complex is required for Ras PAT activity, and mutations within conserved residues (Cys(189), His(201), and Cys(203)) of the Erf2p DHHC-CRD domain abolish Ras PAT activity. Histidine 109-112 palmitoyltransferase ERF2 Saccharomyces cerevisiae S288C 140-145 12366840-5 2002 In fact, using histidine tagging, the existence of a suppressed Cox14p of normal length was demonstrated in mutants expressing the mt-tRNAVAL from the nucleus. Histidine 15-24 Cox14p Saccharomyces cerevisiae S288C 64-70 7848918-4 1994 This complementary DNA, designated Kiz-1, encodes a protein containing two prominent domains; the NH2-terminal region contains a cysteine/histidine-rich moiety previously identified as a zinc-finger domain in proteins of the LIM family, while the COOH-terminus contains a kinase domain. Histidine 138-147 LIM-domain containing, protein kinase Mus musculus 35-40 8556514-2 1994 We investigated the His-Arg (CAT/CGT) polymorphism at codon 131 of the Fc gamma receptor IIA gene, which influences ligand binding by the receptor. Histidine 20-23 UDP glycosyltransferase 8 Homo sapiens 33-36 7852964-8 1994 Two patients, both subtype D strains (D214 and D482) with false negative results in the RTDs, showed a significant amino acid substitution, i.e., substitution of a histidine residue for leucine at env position 607. Histidine 164-173 endogenous retrovirus group K member 20 Homo sapiens 197-200 7980562-0 1994 Peptides corresponding to the region adjacent to His-94 in the small subunit of cytochrome b558 inhibit superoxide generation in a cell-free system from human neutrophils. Histidine 49-52 mitochondrially encoded cytochrome b Homo sapiens 80-92 7980562-1 1994 Synthetic peptides corresponding to the region adjacent to His-94 in the small subunit of cytochrome b558 inhibited superoxide generation in a cell-free system. Histidine 59-62 mitochondrially encoded cytochrome b Homo sapiens 90-102 12105206-7 2002 Site-directed mutagenesis of the EGFR L2 domain showed that a cluster of residues, His(394)-Ile(402), was essential for both decorin and EGF binding. Histidine 83-86 decorin Homo sapiens 125-132 12124384-2 2002 Using recombinant human wild type and mutant MBD3 proteins, we demonstrated that atypical amino acids found in MBD3 MBD, namely, His-30 and Phe-34, are responsible for the inability of MBD3 to bind to mCpG. Histidine 129-132 methyl-CpG binding domain protein 3 Homo sapiens 45-49 12124384-2 2002 Using recombinant human wild type and mutant MBD3 proteins, we demonstrated that atypical amino acids found in MBD3 MBD, namely, His-30 and Phe-34, are responsible for the inability of MBD3 to bind to mCpG. Histidine 129-132 methyl-CpG binding domain protein 3 Homo sapiens 111-115 12124384-2 2002 Using recombinant human wild type and mutant MBD3 proteins, we demonstrated that atypical amino acids found in MBD3 MBD, namely, His-30 and Phe-34, are responsible for the inability of MBD3 to bind to mCpG. Histidine 129-132 methyl-CpG binding domain protein 3 Homo sapiens 111-115 12207908-6 2002 It was suggested that the polymerization of Fas antigen, which was the essential process for the efficient induction of apoptosis, was interfered by the alteration of CRD1, and that this portion, named the "histidine-rich region," played a critical role in Fas assembly. Histidine 207-216 Fas cell surface death receptor Homo sapiens 44-55 12183328-0 2002 An N-terminal histidine regulates Zn(2+) inhibition on the murine GABA(A) receptor beta3 subunit. Histidine 14-23 gamma-aminobutyric acid (GABA) A receptor, subunit beta 3 Mus musculus 83-88 12183328-11 2002 External histidine residues in the beta3 receptor subunit were substituted with alanine, in addition to the background mutation, H267A, to assess their sensitivity to Zn(2+) inhibition. Histidine 9-18 gamma-aminobutyric acid (GABA) A receptor, subunit beta 3 Mus musculus 35-40 12199707-3 2002 By site-directed mutagenesis we have produced three mutants of cyt b5: Phe35-->Tyr, Phe35-->Leu, and Phe35-->His. Histidine 118-121 cytochrome b5 type A Homo sapiens 63-69 12161759-2 2002 We demonstrate this approach for granulocyte colony-stimulating factor by using computationally predicted histidine substitutions that switch protonation states between cell-surface and endosomal pH. Histidine 106-115 colony stimulating factor 3 Homo sapiens 33-70 12042318-5 2002 We compared biochemical and functional features of wild type flavocytochrome b558 with those in cells co-expressing gp91(phox) with p22(phox) harboring amino acid substitutions at histidine 94, the only invariant histidine residue within the p22(phox) subunit. Histidine 180-189 calcineurin like EF-hand protein 1 Homo sapiens 132-135 12070317-1 2002 Nucleoside diphosphate (NDP) kinase is transiently phosphorylated on a histidine of the active site during the catalytic cycle. Histidine 71-80 cytidine/uridine monophosphate kinase 2 Homo sapiens 0-35 12070317-3 2002 We describe the synthesis of an analog of the phosphoenzyme intermediate with an inactive mutant of NDP kinase in which the catalytic histidine is replaced by a cysteine. Histidine 134-143 cytidine/uridine monophosphate kinase 2 Homo sapiens 100-110 12137948-6 2002 Four alleles of dMi-2 mutants were further characterized in molecular nature; dMi-2(BL1) was found to have a mutation in the ATP-binding motif of the ATPase domain, dMi-2(BL7) in the core histidine of the first plant homeodomain zinc finger and dMi-2(BL12) in a conserved serine in the chromodomain. Histidine 188-197 Mi-2 Drosophila melanogaster 16-21 12137948-6 2002 Four alleles of dMi-2 mutants were further characterized in molecular nature; dMi-2(BL1) was found to have a mutation in the ATP-binding motif of the ATPase domain, dMi-2(BL7) in the core histidine of the first plant homeodomain zinc finger and dMi-2(BL12) in a conserved serine in the chromodomain. Histidine 188-197 Mi-2 Drosophila melanogaster 78-83 12137948-6 2002 Four alleles of dMi-2 mutants were further characterized in molecular nature; dMi-2(BL1) was found to have a mutation in the ATP-binding motif of the ATPase domain, dMi-2(BL7) in the core histidine of the first plant homeodomain zinc finger and dMi-2(BL12) in a conserved serine in the chromodomain. Histidine 188-197 Mi-2 Drosophila melanogaster 78-83 12137948-6 2002 Four alleles of dMi-2 mutants were further characterized in molecular nature; dMi-2(BL1) was found to have a mutation in the ATP-binding motif of the ATPase domain, dMi-2(BL7) in the core histidine of the first plant homeodomain zinc finger and dMi-2(BL12) in a conserved serine in the chromodomain. Histidine 188-197 Mi-2 Drosophila melanogaster 78-83 12061882-7 2002 These studies provide further experimental evidence that the His(6) position can determine MC4R versus MC3R agonist selectivity and that chemically nonreactive side chains may be substituted for the imidazole ring (generally needs to be side chain protected in synthetic schemes) in the design of MC4R-selective, small-molecule, non-peptide agonists. Histidine 61-64 melanocortin 4 receptor Mus musculus 91-95 7935399-7 1994 When a fragment covering that region was inserted immediately upstream of the open reading frame of HIS3, the resulting gene fusion, if introduced into a his3 yeast strain, supported growth on histidine-lacking medium. Histidine 193-202 imidazoleglycerol-phosphate dehydratase HIS3 Saccharomyces cerevisiae S288C 100-104 7935399-7 1994 When a fragment covering that region was inserted immediately upstream of the open reading frame of HIS3, the resulting gene fusion, if introduced into a his3 yeast strain, supported growth on histidine-lacking medium. Histidine 193-202 imidazoleglycerol-phosphate dehydratase HIS3 Saccharomyces cerevisiae S288C 154-158 12065401-3 2002 The binding pocket of ABP1 is predominantly hydrophobic with a metal ion deep inside the pocket coordinated by three histidines and a glutamate. Histidine 117-127 auxin-binding protein 1 Zea mays 22-26 11919192-4 2002 Inhibition of caspase-9 with either the peptide inhibitor benzyloxycarbonyl-Leu-Glu(OCH(3))-His-Asp(OCH(3))-fluoromethyl ketone, or expression of a catalytically inactive caspase-9 by retroviral transduction, protected normal keratinocytes from UV-induced apoptosis. Histidine 92-95 caspase 9 Homo sapiens 14-23 11850428-7 2002 The mutation of MBP-A His(189) to its MBP-C equivalent, valine, causes Man alpha 1-3Man to bind in a mixture of orientations. Histidine 22-25 mannose binding lectin 2 Homo sapiens 38-43 12054542-1 2002 Arabidopsis ARR4/ATRR1/IBC7 and ARR8/ATRR3 are homologous genes of prokaryotic response regulators that are involved in the His-Asp phosphorelay signal transduction. Histidine 124-127 response regulator 4 Arabidopsis thaliana 12-16 12054542-1 2002 Arabidopsis ARR4/ATRR1/IBC7 and ARR8/ATRR3 are homologous genes of prokaryotic response regulators that are involved in the His-Asp phosphorelay signal transduction. Histidine 124-127 response regulator 4 Arabidopsis thaliana 17-22 12054542-1 2002 Arabidopsis ARR4/ATRR1/IBC7 and ARR8/ATRR3 are homologous genes of prokaryotic response regulators that are involved in the His-Asp phosphorelay signal transduction. Histidine 124-127 response regulator 4 Arabidopsis thaliana 23-27 11973426-8 2002 Furthermore, intracerebral ventricular infusion of the relatively specific caspase-9 inhibitor N-benzyloxycarbonyl-Leu-Glu-His-Asp-fluoro-methylketone before ischemia attenuated caspase-3-like activity and significantly enhanced neuronal survival in the CA1 sector. Histidine 123-126 caspase-3-like Rattus norvegicus 178-192 11973426-8 2002 Furthermore, intracerebral ventricular infusion of the relatively specific caspase-9 inhibitor N-benzyloxycarbonyl-Leu-Glu-His-Asp-fluoro-methylketone before ischemia attenuated caspase-3-like activity and significantly enhanced neuronal survival in the CA1 sector. Histidine 123-126 carbonic anhydrase 1 Rattus norvegicus 254-257 11906734-3 2002 A plasmid was constructed encoding a recombinant P22 with a Histidine-tag at its N-terminal extremity (P22r). Histidine 60-69 calcineurin like EF-hand protein 1 Homo sapiens 49-52 11916859-7 2002 Because cx46 and cx50 have very similar amino acid sequences, one might expect that replacing the two histidines unique to the third transmembrane region of cx50 with the corresponding cx46 residues would produce mutants more closely resembling cx46. Histidine 102-112 gap junction protein alpha 3 Homo sapiens 8-12 11916859-7 2002 Because cx46 and cx50 have very similar amino acid sequences, one might expect that replacing the two histidines unique to the third transmembrane region of cx50 with the corresponding cx46 residues would produce mutants more closely resembling cx46. Histidine 102-112 gap junction protein alpha 3 Homo sapiens 185-189 11916859-7 2002 Because cx46 and cx50 have very similar amino acid sequences, one might expect that replacing the two histidines unique to the third transmembrane region of cx50 with the corresponding cx46 residues would produce mutants more closely resembling cx46. Histidine 102-112 gap junction protein alpha 3 Homo sapiens 185-189 12419163-9 2002 In Western blot analysis, the single domain antibody from 2 of 4 clones proved to react with the His-tagged hTERT fusion protein (Mr = 167 000) without dependence of His-tags and also detect the native hTERT (Mr = 127 000) extracted from the human HeLa cancer cell line. Histidine 97-100 telomerase reverse transcriptase Homo sapiens 108-113 11781309-8 2002 Furthermore, mutations in this lysine and in a histidine residue that is also predicted to be important for pyridoxal 5"-phosphate binding to Lcb2p also dominantly inactivate SPT similar to the hereditary sensory neuropathy type 1-like mutations in Lcb1p. Histidine 47-56 serine C-palmitoyltransferase LCB1 Saccharomyces cerevisiae S288C 249-254 11866428-7 2002 Our data do not exclude, however, that the histidine sequence simply mimics the lysine motif as a sorting signal, being recognised by and interacting with the same receptor subunit(s) in COP-I-coated vesicles. Histidine 43-52 caspase recruitment domain family member 16 Homo sapiens 187-190 11901108-3 2002 We now show that mutation of a highly conserved histidine residue in Npt1p results in a silencing defect, indicating that Npt1p enzymatic activity is required for silencing. Histidine 48-57 nicotinate phosphoribosyltransferase Saccharomyces cerevisiae S288C 69-74 8091686-5 1994 Comparative sequence analysis showed that tsG VP6 contains two mutant amino acids, i.e., Thr-10 and His-13, and therefore one or both of these mutations are responsible for the ts phenotype of the mutant VP6. Histidine 100-103 twisted gastrulation BMP signaling modulator 1 Homo sapiens 42-45 8091686-8 1994 While influencing intracellular accumulation, the Thr-10-->Ser and His-13-->Asp mutations in tsG VP6 are probably not directly involved in the interaction of VP6 with VP2, as VP6 deletion mutants lacking residues 10 and 13 retain the ability to bind VP2 in vitro. Histidine 70-73 twisted gastrulation BMP signaling modulator 1 Homo sapiens 99-102 8093013-6 1994 Moreover, modification of the second histidine is prevented by the presence of Ca(II). Histidine 37-46 carbonic anhydrase 2 Homo sapiens 79-85 8093013-7 1994 These results indicate that the second histidine is serving as a ligand for Ca(II) and the bound Ca(II) is directly involved in enzyme catalysis. Histidine 39-48 carbonic anhydrase 2 Homo sapiens 76-82 8093013-7 1994 These results indicate that the second histidine is serving as a ligand for Ca(II) and the bound Ca(II) is directly involved in enzyme catalysis. Histidine 39-48 carbonic anhydrase 2 Homo sapiens 97-103 8034673-7 1994 Expression and analysis of site-directed mutants of CPT II showed that histidine 372, as well as aspartates 376 and 464 (all conserved throughout the carnitine/choline acyltransferase family), are essential for catalytic activity. Histidine 71-80 carnitine palmitoyltransferase 2 Rattus norvegicus 52-58 8034673-8 1994 The data suggest that the mechanism by which CPT II effects transesterification between palmitoyl-CoA and carnitine possibly involves histidine 372 and one of these aspartate residues, interacting with the carnitine hydroxyl group, in a reaction analogous to that carried out by a histidine/aspartate/serine catalytic triad in certain other enzyme systems. Histidine 134-143 carnitine palmitoyltransferase 2 Rattus norvegicus 45-51 8034673-8 1994 The data suggest that the mechanism by which CPT II effects transesterification between palmitoyl-CoA and carnitine possibly involves histidine 372 and one of these aspartate residues, interacting with the carnitine hydroxyl group, in a reaction analogous to that carried out by a histidine/aspartate/serine catalytic triad in certain other enzyme systems. Histidine 281-290 carnitine palmitoyltransferase 2 Rattus norvegicus 45-51 7913462-4 1994 rITF2 is a rat homolog of human ITF2 (or E2-2), and CDP2 is a member of a new family of homeoproteins defined by histidine as the 9th residue of the recognition helix and by unique 64 amino acid repeats related to those of the Drosophila cut gene. Histidine 113-122 cut like homeobox 2 Homo sapiens 52-56 8203892-1 1994 Histidine at position 51 of the class I beta 1 alcohol dehydrogenase (ADH) functions as a general base by indirectly abstracting a proton from the alcohol substrate through a hydrogen-bonded proton relay system. Histidine 0-9 aldo-keto reductase family 1 member A1 Homo sapiens 47-68 8203892-1 1994 Histidine at position 51 of the class I beta 1 alcohol dehydrogenase (ADH) functions as a general base by indirectly abstracting a proton from the alcohol substrate through a hydrogen-bonded proton relay system. Histidine 0-9 aldo-keto reductase family 1 member A1 Homo sapiens 70-73 8203892-4 1994 Accordingly, we expressed and purified recombinant mutants of pi-ADH with Thr, Ser, and His at position 51. Histidine 88-91 aldo-keto reductase family 1 member A1 Homo sapiens 65-68 8144590-6 1994 The overall structure of cholinesterases was conserved in ACE-1 as indicated by the conserved sequence positions of Ser-216, His-468, and Glu-346 (S200, H440, E327 in Torpedo (AChE) as components of the catalytic triad, of the six cysteines which form three intrachain disulfide bonds, and of Trp-99(84), a critical side chain in the choline binding site. Histidine 125-128 ACE1 Drosophila melanogaster 58-63 7511204-5 1994 P58, expressed as a histidine fusion protein in Escherichia coli, blocked both the autophosphorylation of PKR and phosphorylation of the alpha subunit of eIF-2. Histidine 20-29 interferon induced protein with tetratricopeptide repeats 5 Homo sapiens 0-3 8276823-2 1994 Two residues are known to play important catalytic roles in fatty acyl-thioester hydrolase, thioesterase II: Ser-101, the site of a covalent acyl-enzyme intermediate, and His-237 which is within hydrogen bonding distance of Ser-101 and facilitates catalysis by increasing the nucleophilicity of this residue. Histidine 171-174 acyl-CoA thioesterase 8 Homo sapiens 92-107 8276829-2 1994 We report properties of five active site mutants of Escherichia coli citrate synthase, in which histidine 264, aspartate 362, and phenylalanine 383 were replaced by alanines, and arginines 387 and 407 by leucines. Histidine 96-105 citrate synthase Sus scrofa 69-85 8276829-5 1994 The mutations of histidine 264 and aspartate 362 affect steady-state kinetics as would be anticipated from current models for citrate synthase catalysis, and resemble mutations of these residues, in pig heart and E. coli enzyme, reported by others. Histidine 17-26 citrate synthase Sus scrofa 126-142 8218383-2 1993 The maximal rate of CO2 hydration catalyzed by human carbonic anhydrase II (carbonate hydro-lyase, EC 4.2.1.1) is limited by proton transfer steps involving the acid-base function of His-64. Histidine 183-186 carbonic anhydrase 2 Homo sapiens 53-74 11901108-3 2002 We now show that mutation of a highly conserved histidine residue in Npt1p results in a silencing defect, indicating that Npt1p enzymatic activity is required for silencing. Histidine 48-57 nicotinate phosphoribosyltransferase Saccharomyces cerevisiae S288C 122-127 11741948-11 2002 By placing DEA into the active site of the open structure, the major forces to stabilize the closed conformation of AdoHcyase are identified as the hydrogen bonds between the backbone of His-352 and the adenine ring, and the C3"-H...C4 interaction. Histidine 187-190 adenosylhomocysteinase Homo sapiens 116-125 11741986-7 2002 The sequence of the protease domain carried the essential triad His, Asp, and Ser and showed some similarity to that of TMPRSS2, hepsin, HAT, MT-SP1, TMPRSS3, and corin, sharing 45.5, 41.9, 41.3, 40.3, 39.1, and 38.5% identity, respectively. Histidine 64-67 ST14 transmembrane serine protease matriptase Homo sapiens 142-148 11741986-7 2002 The sequence of the protease domain carried the essential triad His, Asp, and Ser and showed some similarity to that of TMPRSS2, hepsin, HAT, MT-SP1, TMPRSS3, and corin, sharing 45.5, 41.9, 41.3, 40.3, 39.1, and 38.5% identity, respectively. Histidine 64-67 transmembrane serine protease 3 Homo sapiens 150-157 11723122-4 2002 The relative molar expression of these subtypes was quantified through comparison with histidine-tagged UCP1 or UCP2 proteins engineered by expression in Escherichia coli. Histidine 87-96 uncoupling protein 1 Homo sapiens 104-108 8297136-2 1993 For this purpose a new assay system employing a histidine-tag method of transient expression and rapid purification of recombinant c-Jun, in conjunction with "southwestern" blotting and in situ phosphatase treatment, was developed. Histidine 48-57 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 131-136 8223609-0 1993 Accessibility to modification of histidine residues of RecA protein upon DNA and cofactor binding. Histidine 33-42 RAD51 recombinase Homo sapiens 55-59 8223609-1 1993 The potential role of histidine residues of RecA protein in binding DNA has been investigated by monitoring their accessibility to diethylpyrocarbonate. Histidine 22-31 RAD51 recombinase Homo sapiens 44-48 8223609-3 1993 However, both histidine residues become accessible after addition of cofactor analog adenosine 5"-O-(3-thiotriphosphate) (ATP[S]) indicating a change in the organization of the RecA filament and/or a change in the conformation of protein. Histidine 14-23 RAD51 recombinase Homo sapiens 177-181 8223609-8 1993 A protection of the histidine residues is also effected by high salt concentration which promotes, just as DNA binding, ATPase and coprotease activity in RecA. Histidine 20-29 RAD51 recombinase Homo sapiens 154-158 8223609-9 1993 The protection of histidine residues to diethylpyrocarbonate upon DNA binding probably relates to a conformational change of RecA and may not be any direct effect of shielding by the DNA. Histidine 18-27 RAD51 recombinase Homo sapiens 125-129 11891044-4 2002 All these HELP domain-containing proteins, including mouse KE4, Drosophila Catsup, and Arabidopsis IAR1, possessed multipass transmembrane domains and histidine-rich sequences. Histidine 151-160 solute carrier family 39 (zinc transporter), member 7 Mus musculus 59-62 11827471-4 2002 The primary binding site near prgX includes an 11 bp palindromic sequence and showed relatively high affinity for His-tagged PrgX (His-PrgX). Histidine 114-117 PrgX Enterococcus faecalis 30-34 11827471-4 2002 The primary binding site near prgX includes an 11 bp palindromic sequence and showed relatively high affinity for His-tagged PrgX (His-PrgX). Histidine 114-117 PrgX Enterococcus faecalis 125-129 11827471-4 2002 The primary binding site near prgX includes an 11 bp palindromic sequence and showed relatively high affinity for His-tagged PrgX (His-PrgX). Histidine 114-117 PrgX Enterococcus faecalis 135-139 11827471-4 2002 The primary binding site near prgX includes an 11 bp palindromic sequence and showed relatively high affinity for His-tagged PrgX (His-PrgX). Histidine 131-134 PrgX Enterococcus faecalis 30-34 11827471-4 2002 The primary binding site near prgX includes an 11 bp palindromic sequence and showed relatively high affinity for His-tagged PrgX (His-PrgX). Histidine 131-134 PrgX Enterococcus faecalis 125-129 11827471-4 2002 The primary binding site near prgX includes an 11 bp palindromic sequence and showed relatively high affinity for His-tagged PrgX (His-PrgX). Histidine 131-134 PrgX Enterococcus faecalis 135-139 11812233-9 2002 A far UV circular dichroism spectrum revealed that His-tagged S. aureus Pth appears to have a structured core predominated by beta-sheet. Histidine 51-54 AT695_RS00135 Staphylococcus aureus 72-75 14961282-6 2002 A recombinant protein of zebrafish RPA p32 containing a short histidine tag at the NH(2)-terminus was overexpressed in Escherichia coli BL21(DE3) pLys using an inducible T7 expression system, and was purified by Ni-NTA affinity chromatography. Histidine 62-71 replication protein A2 Danio rerio 35-42 11814878-1 2002 N-Bromosuccinimide (NBS) is a known protein reagent able to modify amino acids and proteins, resulting in oxidation of tryptophan, tyrosine and histidine residues, as well as sulfhydryl, alcohol and phenol groups. Histidine 144-153 nibrin Homo sapiens 20-23 8216277-3 1993 Upon the modification of about 5 of the total 22 histidine residues in the SecA molecule, both the abolition of its translocation ATPase activity and the enhancement of its SecA-ATPase activity occurred. Histidine 49-58 ATPase Escherichia coli 130-136 8216277-3 1993 Upon the modification of about 5 of the total 22 histidine residues in the SecA molecule, both the abolition of its translocation ATPase activity and the enhancement of its SecA-ATPase activity occurred. Histidine 49-58 ATPase Escherichia coli 173-184 8216277-6 1993 Taken together, these results indicate that histidine residues susceptible to diethylpyrocarbonate are essential for the translocation ATPase, but not directly involved in the binding of ATP, proOmpA and membranes. Histidine 44-53 ATPase Escherichia coli 135-141 8369304-0 1993 Active site labeling of the Yersinia protein tyrosine phosphatase: the determination of the pKa of the active site cysteine and the function of the conserved histidine 402. Histidine 158-167 protein tyrosine phosphatase non-receptor type 22 Homo sapiens 37-65 11739744-5 2002 A histidine-rich stretch, which is conserved between CycT1 and CycT2 in this region, bound the C-terminal domain of RNAPII. Histidine 2-11 cyclin T2 Homo sapiens 63-68 20569305-4 2002 Expression of AAT1p in a histidine uptake-defective yeast mutant revealed energy-dependent transport of (14)C-histidine, with a K(M) value of 25.8 microm. Histidine 25-34 aspartate transaminase AAT1 Saccharomyces cerevisiae S288C 14-19 7688509-1 1993 An anti-peptide antibody was raised against the sequence Thr-Gly-Ala-Leu-Phe-Lys-His-Ser-Glu-Asn-Tyr-Lys which occurs at positions 283-294 in the rat cytochrome P450 enzyme CYP1A2. Histidine 81-84 cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus 173-179 8341706-2 1993 The purification and characterization of the recombinant FKBP-52 (rFKBP-52) was facilitated by incorporating a histidine 6-mer domain at its N terminus. Histidine 111-120 FKBP prolyl isomerase 4 Rattus norvegicus 57-64 8341706-2 1993 The purification and characterization of the recombinant FKBP-52 (rFKBP-52) was facilitated by incorporating a histidine 6-mer domain at its N terminus. Histidine 111-120 FKBP prolyl isomerase 4 Rattus norvegicus 66-74 7687248-8 1993 Sequence analysis of the cloned histidine region, which revealed 98.6% overall homology with that of the previously analyzed prototrophic strain, showed the presence of frameshift mutations in three his genes, hisC, hisG, and hisH, and two genes unrelated to histidine biosynthesis, ORF3 and ORF6. Histidine 32-41 orf3 Lactococcus lactis 283-287 8370667-2 1993 Both cDNAs were inserted into a baculovirus vector which mediated highly efficient expression of the human GAD65 and GAD67 with histidine-hexapeptides as affinity ligands at their C-termini in Spodoptera frugiperda (Sf9) cells. Histidine 128-137 glutamate decarboxylase 1 Homo sapiens 117-122 8212073-4 1993 This mutation is located within exon 2 and alters the codon (CTC) normally associated with Leu-93 in the transcortin polypeptide to a codon (CAC) for histidine in the variant genes. Histidine 150-159 carbonic anhydrase 2 Homo sapiens 141-144 8392938-4 1993 The histidine alkylating agent diethylpyrocarbonate potently inhibited binding of [125I]endothelin-1 to its receptors in bovine cerebellum, where a single population of endothelin ETB receptors was shown to exist. Histidine 4-13 endothelin 1 Bos taurus 88-100 8320037-9 1993 The nucleotide sequence analyses demonstrated that the codon CGT for -2 Arg was mutated to CAT for His. Histidine 99-102 UDP glycosyltransferase 8 Homo sapiens 61-64 8484779-2 1993 We expressed mouse CSF-1 in bacteria as a fusion protein either with glutathione S-transferase (GST) or with a six histidine tag (His-tag). Histidine 115-124 colony stimulating factor 1 (macrophage) Mus musculus 19-24 8484779-2 1993 We expressed mouse CSF-1 in bacteria as a fusion protein either with glutathione S-transferase (GST) or with a six histidine tag (His-tag). Histidine 130-133 colony stimulating factor 1 (macrophage) Mus musculus 19-24 8471773-4 1993 From these 43 samples, we have identified five different types of nucleotide substitutions in the G6PD gene: at cDNA 1388 from G to A (Arg to His); at cDNA 1376 from G to T (Arg to Leu); at cDNA 1024 from C to T (Leu to Phe); at cDNA 392 from G to T (Gly to Val); at cDNA 95 from A to G (His to Arg). Histidine 142-145 glucose-6-phosphate dehydrogenase Homo sapiens 98-102 8471773-4 1993 From these 43 samples, we have identified five different types of nucleotide substitutions in the G6PD gene: at cDNA 1388 from G to A (Arg to His); at cDNA 1376 from G to T (Arg to Leu); at cDNA 1024 from C to T (Leu to Phe); at cDNA 392 from G to T (Gly to Val); at cDNA 95 from A to G (His to Arg). Histidine 288-291 glucose-6-phosphate dehydrogenase Homo sapiens 98-102 20569305-6 2002 Using Xenopus oocytes as expression system, AAT1p-dependent symport of protons with a broad spectrum of amino acids was observed, with the highest activities obtained with histidine and lysine. Histidine 172-181 aspartate transaminase AAT1 Saccharomyces cerevisiae S288C 44-49 11750057-7 2001 In addition, mutational analysis of His(6)-p15 demonstrated that both intramolecular disulfide bonds are essential for its biological activity. Histidine 36-39 cyclin-dependent kinase inhibitor 2B Rattus norvegicus 43-46 11724901-3 2001 We have developed a rabbit polyclonal antibody, SK601, that is highly specific for the PTTG1 gene product using recombinant PTTG1 protein (24 kD) containing an N-terminal His(6) tag as the immunogen. Histidine 171-174 PTTG1 regulator of sister chromatid separation, securin Homo sapiens 87-92 11738047-6 2001 The L19 peptide is in a centrally bulged conformation that is stabilized by intramolecular interactions from the invariant P7 histidine anchor residue and by a hydrophobic core of preferred secondary anchor residues that have minimal interaction with the MHC. Histidine 126-135 skull development traits QTL 11 Mus musculus 4-7 11716696-7 2001 Upon postlabeling of [K4(PADA)]-NPY, 99mTc(CO)3 did not only bind to the desired PADA, but presumably as well to the His in position 26. Histidine 117-120 neuropeptide Y Homo sapiens 32-35 11597395-3 2001 GC109 harbours a putative Cys-His cluster, a nuclear localisation signal, a leucine zipper and a ret finger protein (rfp)-like domain. Histidine 30-33 tripartite motif containing 68 Homo sapiens 0-5 11676607-7 2001 Insertion of a small oligopeptide (13 amino acids) containing the histidine hexamer and factor Xa cleavage site between the signal peptide and the mature hG-CSF protein allowed successful secretion of hG-CSF into the periplasm without cell lysis. Histidine 66-75 colony stimulating factor 3 Homo sapiens 201-207 11677272-3 2001 We prepared two His-tagged recombinant 7B2s by overexpression in bacteria: 7B2-Ser-Ser (SS), with an inactivating mutation in the CT peptide from Lys171-Lys172 (KK) to SS, rendering the CT peptide non-inhibitory; blockade-SS, a double mutant of both the CT peptide as well as of the pentabasic furin cleavage site. Histidine 16-19 secretogranin V Homo sapiens 39-42 11415439-3 2001 We demonstrate here that CaBP1, similar to PDI and CaBP2, can complement the lethal phenotype of the disrupted Saccharomyces cerevisiae PDI gene, provided that the natural C-terminal Lys-Asp-Glu-Leu sequence is replaced by His-Asp-Glu-Leu. Histidine 223-226 calcium binding protein 1 Rattus norvegicus 25-30 11341833-2 2001 We have previously shown by proton NMR that horse serum butyryl cholinesterase, like serine proteases, forms a short, strong hydrogen bond (SSHB) between the Glu-His pair upon binding mechanism-based inhibitors, which form tetrahedral adducts, analogous to the tetrahedral intermediates in catalysis [Viragh, C., et al. Histidine 162-165 butyrylcholinesterase Homo sapiens 56-78 11325944-7 2001 The portion of GST-Bc responsible for the interference phenotype was localized using truncation, linker insertion, and point mutations to the region between residues 293 and 366 flanking His-313, the putative site of autophosphorylation. Histidine 187-190 glutathione S-transferase kappa 1 Homo sapiens 15-18 11325944-12 2001 Reverse transfer of phosphate from P-UhpA to GST-Bc was observed in the presence of the metal chelator EDTA and depended on the presence of His-313. Histidine 140-143 glutathione S-transferase kappa 1 Homo sapiens 45-48 11457012-0 2001 Raman spectroscopic and electrochemical characterization of myoglobin thin film: implication of the role of histidine 64 for fast heterogeneous electron transfer. Histidine 108-117 myoglobin Homo sapiens 60-69 11264017-2 2001 The Cys(2)/His(2) zinc finger is a structural motif required for sequence-specific DNA binding and is present in zinc finger transcription factors (ZFP): Sp1, Egr-1, and TFIIIA. Histidine 11-14 early growth response 1 Homo sapiens 159-164 11160624-0 2001 Differential sensitivity of Kv1.4, Kv1.2, and their tandem channel to acidic pH: involvement of a histidine residue in high sensitivity to acidic pH. Histidine 98-107 potassium voltage-gated channel subfamily A member 4 Homo sapiens 28-33 11160624-4 2001 Mutagenesis analysis identified the histidine residue at 508 (H508) in the S5-H5 linker as a molecular determinant of pH sensitivity of Kv1.4. Histidine 36-45 potassium voltage-gated channel subfamily A member 4 Homo sapiens 136-141 11604705-0 2001 "THE PILOT": a tool for connecting existing HIS to an extranet quickly, easily and smoothly. Histidine 44-47 early growth response 3 Homo sapiens 5-11 11082187-3 2000 Six specific His-CDC2aAt-binding phage clones (3D1, 3D2, 3D10, 3D25, 4D21 and 4D47) were isolated by panning. Histidine 13-16 cell division control 2 Arabidopsis thaliana 17-24 11082187-4 2000 The isolated monoclonal phage clones, as well as the soluble scFv fragments produced in the periplasm of Escherichia coli, bind His-CDC2aAt in ELISA and on Western blots. Histidine 128-131 cell division control 2 Arabidopsis thaliana 132-139 11082042-3 2000 The deduced amino acid sequence of porcine thyroid cathepsin K predicted a 37 kDa preproenzyme, with the active site residues Cys-140, His-277 and Asn-297, and one potential N-glycosylation site. Histidine 135-138 cathepsin K Homo sapiens 51-62 10958790-2 2000 MTF-1 contains six zinc fingers of the Cys(2)-His(2) type. Histidine 46-49 metal response element binding transcription factor 1 Mus musculus 0-5 10958787-0 2000 Interactions of Cdk7 and Kin28 with Hint/PKCI-1 and Hnt1 histidine triad proteins. Histidine 57-66 TFIIH complex serine/threonine-protein kinase subunit KIN28 Saccharomyces cerevisiae S288C 25-30 10958787-6 2000 The physical and genetic interactions of Hint and Hnt1 with Cdk7 and Kin28 suggest a role for this class of histidine triad proteins in the regulation of Cdk7 and Kin28 functions. Histidine 108-117 TFIIH complex serine/threonine-protein kinase subunit KIN28 Saccharomyces cerevisiae S288C 69-74 10958787-6 2000 The physical and genetic interactions of Hint and Hnt1 with Cdk7 and Kin28 suggest a role for this class of histidine triad proteins in the regulation of Cdk7 and Kin28 functions. Histidine 108-117 TFIIH complex serine/threonine-protein kinase subunit KIN28 Saccharomyces cerevisiae S288C 163-168 11029294-12 2000 Combined mutations of the lysine and histidine residues in Kir4.1 (K53V/S328H/G340H) gave rise to a channel that had CO(2)/pH sensitivities almost identical to those of the wild-type Kir1.1. Histidine 37-46 potassium inwardly rectifying channel subfamily J member 10 Homo sapiens 59-65 11205269-0 2000 Failure of detection of the tyrosine to histidine substitution at the residue 33 of thymidylate synthase in human colorectal cancer. Histidine 40-49 thymidylate synthetase Homo sapiens 84-104 8096060-4 1993 Two N-terminal erb A amino acids in particular, histidine 12 and cysteine 32, contribute to this phenomenon, acting in conjunction with amino acids in the zinc finger domain. Histidine 48-57 thyroid hormone receptor alpha Homo sapiens 15-20 8459399-4 1993 It is proposed that this selectivity reflects interactions with histidine residues on a loop located in the primed subsites of cathepsin B which provides a positively charged anchor for the C-terminal carboxylate group of the inhibitor. Histidine 64-73 cathepsin B Homo sapiens 127-138 8449909-10 1993 These experiments confirm that in the active enzyme Zn2+ plays a critical role in catalysis, that a histidine or glutamate residue plays a mechanistic role in the hydrolytic deamination step, and that cysteine is not involved in the catalytic mechanism of adenosine deaminase. Histidine 100-109 adenosine deaminase Homo sapiens 256-275 11078388-4 2000 Chronic LU135252 treatment completely prevented activation of renal ACE activity (13.3 +/- 0.3 His-Leu/mg protein nmol/l, p < 0.05) independent of ACE mRNA expression or renal ET-1 protein levels. Histidine 95-98 angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 Mus musculus 68-71 8445019-4 1993 A point mutation was discovered that changed codon 65 from arginine (CGT) to histidine (CAT) in one allele. Histidine 77-86 UDP glycosyltransferase 8 Homo sapiens 69-72 8447816-0 1993 Histidine residues are essential for the surface binding and autoactivation of human coagulation factor XII. Histidine 0-9 coagulation factor XII Homo sapiens 85-107 8431430-0 1993 Engineering the zinc binding site of human carbonic anhydrase II: structure of the His-94-->Cys apoenzyme in a new crystalline form. Histidine 83-86 carbonic anhydrase 2 Homo sapiens 43-64 8431430-1 1993 The structure of the His-94-->Cys variant of human carbonic anhydrase II (CAII) has been determined by X-ray crystallographic methods to a resolution of 2.3 A with a final crystallographic R factor of 0.155. Histidine 21-24 carbonic anhydrase 2 Homo sapiens 54-75 8431430-1 1993 The structure of the His-94-->Cys variant of human carbonic anhydrase II (CAII) has been determined by X-ray crystallographic methods to a resolution of 2.3 A with a final crystallographic R factor of 0.155. Histidine 21-24 carbonic anhydrase 2 Homo sapiens 77-81 8431430-7 1993 Spectroscopic analysis of Co(2+)-substituted His-94-->Cys CAII indicates that the metal binds in a tetrahedral geometry with a new thiolate bond. Histidine 45-48 carbonic anhydrase 2 Homo sapiens 61-65 8096552-7 1993 Comparison of the amino acid residues of DRB1 chain suggested that the basic amino acid at position 13, which is present only on the DR2 and DR4 B1 molecules (Arg on DR2 and His on DR4), contributes to the susceptibility to autoimmune hepatitis among Japanese. Histidine 174-177 major histocompatibility complex, class II, DR beta 4 Homo sapiens 141-144 8096552-7 1993 Comparison of the amino acid residues of DRB1 chain suggested that the basic amino acid at position 13, which is present only on the DR2 and DR4 B1 molecules (Arg on DR2 and His on DR4), contributes to the susceptibility to autoimmune hepatitis among Japanese. Histidine 174-177 major histocompatibility complex, class II, DR beta 4 Homo sapiens 181-184 1491459-7 1992 3) Analysis of carbonic anhydrase II (CA II) gene in a Belgian family with renal tubular acidosis associated with osteoporosis and cerebral calcification has shown a point mutation replacing an invariant histidine residue of CA II protein with tyrosine. Histidine 204-213 carbonic anhydrase 2 Homo sapiens 15-36 1491459-7 1992 3) Analysis of carbonic anhydrase II (CA II) gene in a Belgian family with renal tubular acidosis associated with osteoporosis and cerebral calcification has shown a point mutation replacing an invariant histidine residue of CA II protein with tyrosine. Histidine 204-213 carbonic anhydrase 2 Homo sapiens 38-43 1491459-7 1992 3) Analysis of carbonic anhydrase II (CA II) gene in a Belgian family with renal tubular acidosis associated with osteoporosis and cerebral calcification has shown a point mutation replacing an invariant histidine residue of CA II protein with tyrosine. Histidine 204-213 carbonic anhydrase 2 Homo sapiens 225-230 11065275-1 2000 Human annexin V cDNA was cloned into plasmid pET19b and fused to a ten consecutive histidine tag at N-terminal. Histidine 83-92 annexin A5 Homo sapiens 6-15 1385407-5 1992 Conservative substitutions of 2 highly conserved basic residues in the SH2-N domain, an arginine and a histidine, resulted in complete loss of receptor and p62 binding, whereas other basic residues, and residues at variable SH2 sites, were more tolerant of substitution. Histidine 103-112 nucleoporin 62 Homo sapiens 156-159 1527531-1 1992 The effect of replacement of the highly conserved Lys45 residue in pig myoglobin (Mb) with His, Ser, Glu, and Arg has been investigated. Histidine 91-94 myoglobin Sus scrofa 71-80 1324923-5 1992 Mutant receptors with the carboxyl-terminal His-Leu-Leu-Pro-Met67 residues deleted or replaced with alanines sorted cathepsin D below the base-line value. Histidine 44-47 cathepsin D Bos taurus 116-127 1324923-6 1992 A mutant receptor with the outermost Pro-Met residues replaced with alanines sorted cathepsin D better than the wild-type receptor, indicating that the essential residues for sorting are the His-Leu-Leu sequence. Histidine 191-194 cathepsin D Bos taurus 84-95 1354487-0 1992 Proton transfer roles of lysine 64 and glutamic acid 64 replacing histidine 64 in the active site of human carbonic anhydrase II. Histidine 66-75 carbonic anhydrase 2 Homo sapiens 107-128 1630899-2 1992 Based on analogies with metalloenzymes, it is hypothesized that the two conserved His residues in this motif may be involved in metal ion coordination required for the activity of the Rep and Mob proteins. Histidine 82-85 sphingomyelin synthase 1 Homo sapiens 192-195 1331770-4 1992 At low ionic strength (I = 0-0.1) the pH dependence curve was found to have a sigmoid shape with pKeff approximately 5.7, implying the effect of ionization of His-119(GH1) at the "active site" of myoglobin on the kinetics of the process. Histidine 159-162 somatotropin Sus scrofa 167-170 1331770-7 1992 It is greater at pH less than or equal to 6 and smaller at pH 7.5, which is due to deprotonation of His(GH1). Histidine 100-103 somatotropin Sus scrofa 104-107 1331770-10 1992 This suggests that His(GH1) is directly involved in the mechanism of electron transfer from Mb to Cyt c. The data obtained are compared with earlier data on the effect of pH, ionic strength and zinc ions on the reaction between MbO2 from sperm whale and Cyt c. To explain the higher efficiency of pig MbO2 as electron donor, the electrostatic and steric properties of both myoglobins have been analyzed. Histidine 19-22 somatotropin Sus scrofa 23-26 11012667-2 2000 Complete exchange was observed with histidine-tagged derivatives of LC17a, LC17b and E122A-LC17a (LC17a and LC17b are the usual constituants of smooth muscle myosin), with small changes in the ATPase activity of reconstituted myosins. Histidine 36-45 myosin heavy chain 14 Homo sapiens 158-164 11054275-4 2000 Bacterially expressed ChIL-18 in which the N-terminal 29 amino acids of the putative precursor molecule were replaced by a histidine tag induced the synthesis of interferon-gamma (IFN-gamma) in cultured primary chicken spleen cells, indicating that the recombinant protein is biologically active. Histidine 123-132 interleukin 18 Gallus gallus 22-29 10975859-4 2000 Both caspase-3 inhibitor Z-Asp(OCH3)-Glu(OCH3)-Val-Asp(OCH3)-CH2F and caspase-9 inhibitor Z-Leu-Glu(OCH3)-His-Asp(OCH3)-CH2F prevented the chondrocyte death. Histidine 106-109 caspase 9 Homo sapiens 70-79 10869342-9 2000 Identification of a modified histidine and analysis of cobU mutants indicate that histidine 46 is the site of guanylylation. Histidine 82-91 bifunctional adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 55-59 10999600-4 2000 Comparison of the yeast and human UPF1 proteins demonstrated that the amino terminal cysteine/histidine-rich region and the region comprising the domains that define this protein as a superfamily group I helicase have been conserved. Histidine 94-103 UPF1 RNA helicase and ATPase Homo sapiens 34-38 10816589-10 2000 Replacement of the amino-terminal His residue by Ala abolishes the ability of KIR2DL1 to bind Co(2+), indicating that Co(2+)-mediated KIR2DL1 dimerization involves pairing of the D1 domain. Histidine 34-37 killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1 Homo sapiens 78-85 1371749-13 1992 Since catalysis of ATP-citrate lyase is postulated to involve the formation of phosphohistidine, these results are consistent with the pattern of earlier observations of the significance of the histidine residue in catalysis of the human ATP-citrate lyase. Histidine 86-95 ATP citrate lyase Homo sapiens 19-36 1371749-13 1992 Since catalysis of ATP-citrate lyase is postulated to involve the formation of phosphohistidine, these results are consistent with the pattern of earlier observations of the significance of the histidine residue in catalysis of the human ATP-citrate lyase. Histidine 86-95 ATP citrate lyase Homo sapiens 238-255 1561009-1 1992 Histidine-rich glycoprotein (HRG) is a 74-kD glycoprotein, originally discovered in plasma, which contains an unusually large amount of histidine (13 mol%) and proline (13 mol%). Histidine 136-145 histidine rich glycoprotein Homo sapiens 0-27 1561009-1 1992 Histidine-rich glycoprotein (HRG) is a 74-kD glycoprotein, originally discovered in plasma, which contains an unusually large amount of histidine (13 mol%) and proline (13 mol%). Histidine 136-145 histidine rich glycoprotein Homo sapiens 29-32 1730643-3 1992 Two genes (EFT1 and EFT2) were isolated by screening a bacteriophage lambda yeast genomic DNA library with an oligonucleotide probe complementary to the domain of EF-2 that contains diphthamide, the unique posttranslationally modified histidine that is specifically ADP-ribosylated by diphtheria toxin. Histidine 235-244 elongation factor 2 Saccharomyces cerevisiae S288C 11-15 10816589-10 2000 Replacement of the amino-terminal His residue by Ala abolishes the ability of KIR2DL1 to bind Co(2+), indicating that Co(2+)-mediated KIR2DL1 dimerization involves pairing of the D1 domain. Histidine 34-37 killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1 Homo sapiens 134-141 10899637-4 2000 The inactivated dimer was hybridized with native dimeric muscle enzyme (MM-CK) to produce a partially inactivated MB*-CK heterodimeric hybrid and also to a his-tagged BB-CK (hBhB-CK) resulting in a partially inactive hBB*-CK homodimer. Histidine 156-159 hemoglobin subunit beta Homo sapiens 167-169 10764763-1 2000 The contribution of Arg(129) of the serpin, antithrombin, to the mechanism of allosteric activation of the protein by heparin was determined from the effect of mutating this residue to either His or Gln. Histidine 192-195 serpin family C member 1 Homo sapiens 44-56 27286379-5 1992 On the other hand, pancreatic lipase activity was stimulated by not only BSA, but L-histidine and L-aspartic acid as N-end amino groups of BSA and additionally accelerated it in combination with bile salts. Histidine 82-93 pancreatic lipase Homo sapiens 19-36 1928091-0 1991 Carbonic anhydrase II deficiency syndrome in a Belgian family is caused by a point mutation at an invariant histidine residue (107 His----Tyr): complete structure of the normal human CA II gene. Histidine 108-117 carbonic anhydrase 2 Homo sapiens 183-188 1928091-5 1991 His-107 appears to have a stabilizing function in the structure of all CA molecules, and its substitution by Tyr apparently disrupts the critical hydrogen bonding of His-107 to two other similarly invariant residues, Glu-117 and Tyr-194, resulting in an unstable CA II molecule. Histidine 0-3 carbonic anhydrase 2 Homo sapiens 263-268 1928091-5 1991 His-107 appears to have a stabilizing function in the structure of all CA molecules, and its substitution by Tyr apparently disrupts the critical hydrogen bonding of His-107 to two other similarly invariant residues, Glu-117 and Tyr-194, resulting in an unstable CA II molecule. Histidine 166-169 carbonic anhydrase 2 Homo sapiens 263-268 1665866-3 1991 In a basal medium consisting of 75% DMEM, 25% Ham"s F-12, 5 nM sodium selenite, 50 microM 2-amino ethanol, and 2 mM histidine, supplemented with 5% FBS, we showed that aFGF, bFGF, and PDGF were all capable of stimulating Schwann cell growth and the stimulation was greatly potentiated by forskolin and dibutyryl-cAMP. Histidine 116-125 fibroblast growth factor 1 Rattus norvegicus 168-172 1716370-0 1991 The peptide Glu-His-Ile-Pro-Ala binds fibrinogen and inhibits platelet aggregation and adhesion to fibrinogen and vitronectin. Histidine 16-19 vitronectin Homo sapiens 114-125 10843688-5 2000 A histidine-tagged form of porcine sB7-1 (sB7-1-His) interacted with both CD28 and CTLA-4, and effectively blocked IL-2 production from human responder cells stimulated with PHA and either porcine or human stimulator cells. Histidine 2-11 cytotoxic T-lymphocyte associated protein 4 Homo sapiens 83-89 10818253-1 2000 The abundance of a histidine residue at position 185 (His(185)) of the human corticotropin-releasing factor (CRF) type 2 alpha receptor (hCRF(2alpha)) was investigated. Histidine 19-28 corticotropin releasing hormone Homo sapiens 77-107 10818253-1 2000 The abundance of a histidine residue at position 185 (His(185)) of the human corticotropin-releasing factor (CRF) type 2 alpha receptor (hCRF(2alpha)) was investigated. Histidine 19-28 corticotropin releasing hormone Homo sapiens 137-141 10818253-1 2000 The abundance of a histidine residue at position 185 (His(185)) of the human corticotropin-releasing factor (CRF) type 2 alpha receptor (hCRF(2alpha)) was investigated. Histidine 54-57 corticotropin releasing hormone Homo sapiens 77-107 10818253-1 2000 The abundance of a histidine residue at position 185 (His(185)) of the human corticotropin-releasing factor (CRF) type 2 alpha receptor (hCRF(2alpha)) was investigated. Histidine 54-57 corticotropin releasing hormone Homo sapiens 137-141 10764730-2 2000 An important component of this system is the histidine-containing phosphocarrier protein, HPr, which accepts a phosphoryl group from enzyme I, transfers a phosphoryl group to IIA proteins, and is an allosteric regulator of glycogen phosphorylase. Histidine 45-54 colicin Ia immunity protein Escherichia coli 175-178 10825448-0 2000 Diethyl pyrocarbonate inactivates CD39/ecto-ATPDase by modifying His-59. Histidine 65-68 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 34-38 10825448-0 2000 Diethyl pyrocarbonate inactivates CD39/ecto-ATPDase by modifying His-59. Histidine 65-68 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 44-51 10825448-6 2000 Comparison of known sequences of CD39-like ecto-ATP(D)ases with the results on inactivation by DEPC revealed His-59 and His-251 (according to the human CD39 sequence) as equally possible targets of the inactivating DEPC modification. Histidine 109-112 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 33-37 10825448-6 2000 Comparison of known sequences of CD39-like ecto-ATP(D)ases with the results on inactivation by DEPC revealed His-59 and His-251 (according to the human CD39 sequence) as equally possible targets of the inactivating DEPC modification. Histidine 120-123 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 33-37 10825448-8 2000 Therefore, this enzyme was exposed to DEPC, and since hydrolysis of ATP and ADP by potato apyrase was insensitive to modification with DEPC, it was concluded that His-59 is the essential residue in CD39 that is affected by DEPC modification in a way that causes inactivation of the enzyme. Histidine 163-166 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 198-202 10833400-8 2000 The plant-produced GM-CSF was biologically active and could be bound to a nickel affinity matrix, indicating that both the receptor-binding region and the 6-His tag were functional. Histidine 157-160 colony stimulating factor 2 Homo sapiens 19-25 10832103-4 2000 Introduction of single mutations into either of the histidine residues at positions 136 and 272, putative active sites, entirely abolished the activity, supporting a common mechanism for the nSMase family independent of the species. Histidine 52-61 sphingomyelin phosphodiesterase 2 Rattus norvegicus 191-197 1883837-4 1991 The Dromsopa opa repeat codes for the usual stretch of poly(glutamine) interrupted by histidine residues. Histidine 86-95 male-specific opa containing gene Drosophila melanogaster 4-12 1711082-4 1991 An antibody-binding assay using overlapping synthetic oligopeptides showed that LAT-27 bound specifically to 10-mer peptides that contained the gp46 amino acid sequence 191-196 (Leu-Pro-His-Ser-Asn-Leu). Histidine 186-189 serpin family H member 1 Homo sapiens 144-148 1851482-2 1991 A derivative with histidines selectively deuteriated in the C2 position has been used for the detection of the HC2 histidine protons, 16 out of 17 observed signals of the 18 active-site histidine ring protons have been assigned. Histidine 18-28 CYCS pseudogene 38 Homo sapiens 111-114 1851482-2 1991 A derivative with histidines selectively deuteriated in the C2 position has been used for the detection of the HC2 histidine protons, 16 out of 17 observed signals of the 18 active-site histidine ring protons have been assigned. Histidine 18-27 CYCS pseudogene 38 Homo sapiens 111-114 1851482-2 1991 A derivative with histidines selectively deuteriated in the C2 position has been used for the detection of the HC2 histidine protons, 16 out of 17 observed signals of the 18 active-site histidine ring protons have been assigned. Histidine 115-124 CYCS pseudogene 38 Homo sapiens 111-114 1850190-5 1991 Comparative peptide mapping, by HPLC, of the acidic variant carriers and of normal TTR showed the presence of an abnormal tryptic peptide, not present in the normal TTR digests, with an asparagine-for-histidine substitution at position 90 explained by a single base change of adenine for cytosine in the histidine codon. Histidine 201-210 transthyretin Homo sapiens 83-86 10832103-5 2000 However, mutation in histidine 151, conserved only in eukaryotes, also abolished the activity, suggesting eukaryote-specific control of nSMase linked to this histidine 151. Histidine 21-30 sphingomyelin phosphodiesterase 2 Rattus norvegicus 136-142 10832103-5 2000 However, mutation in histidine 151, conserved only in eukaryotes, also abolished the activity, suggesting eukaryote-specific control of nSMase linked to this histidine 151. Histidine 158-167 sphingomyelin phosphodiesterase 2 Rattus norvegicus 136-142 10748221-6 2000 Each bundle contains the sequence Cys-X(4)-Cys-X(8)-His-X(3)-Cys, and we show that a synthetic peptide comprising one zinc bundle from CH1 can fold in a zinc-dependent manner. Histidine 52-55 SUN domain containing ossification factor Homo sapiens 135-138 10788795-1 2000 The ArcB sensor plays a crucial role in the histidine to aspartate (His-to-Asp) phosphorelay signal transduction, which is involved in the transcriptional regulatory network that allows Escherichia coli cells to sense various respiratory growth conditions. Histidine 44-53 hypothetical protein Escherichia coli 4-8 10788795-1 2000 The ArcB sensor plays a crucial role in the histidine to aspartate (His-to-Asp) phosphorelay signal transduction, which is involved in the transcriptional regulatory network that allows Escherichia coli cells to sense various respiratory growth conditions. Histidine 68-71 hypothetical protein Escherichia coli 4-8 10788795-2 2000 ArcB is one of the best-studied hybrid His-kinases involved in the multi-step His-to-Asp phosphorelay. Histidine 39-42 hypothetical protein Escherichia coli 0-4 10766788-7 2000 Based on sequence identity with the mammalian enzymes the proximal ligand in HO-1 (His-25) and HO-2 (His-45) is conserved (His-20) in the bacterial enzyme. Histidine 83-86 heme oxygenase 1 Homo sapiens 77-81 10766788-7 2000 Based on sequence identity with the mammalian enzymes the proximal ligand in HO-1 (His-25) and HO-2 (His-45) is conserved (His-20) in the bacterial enzyme. Histidine 101-104 heme oxygenase 1 Homo sapiens 77-81 10766788-7 2000 Based on sequence identity with the mammalian enzymes the proximal ligand in HO-1 (His-25) and HO-2 (His-45) is conserved (His-20) in the bacterial enzyme. Histidine 101-104 heme oxygenase 1 Homo sapiens 77-81 10715127-3 2000 Aligning the sequences of the mouse APA, APN, and other monozinc aminopeptidases led to the identification of a conserved histidine (His 450 in mouse APA). Histidine 122-131 alanyl (membrane) aminopeptidase Mus musculus 41-44 10715127-3 2000 Aligning the sequences of the mouse APA, APN, and other monozinc aminopeptidases led to the identification of a conserved histidine (His 450 in mouse APA). Histidine 133-136 alanyl (membrane) aminopeptidase Mus musculus 41-44 10712555-0 2000 Molecular cloning and characterization of ATP-phosphoribosyl transferase from Arabidopsis, a key enzyme in the histidine biosynthetic pathway. Histidine 111-120 ATP phosphoribosyl transferase 1 Arabidopsis thaliana 42-72 10651811-7 2000 Using these tools, it was demonstrated that the soluble His-tagged form of DnaJ protein exclusively binds the cytosolic isoform 1 of Hsp70. Histidine 56-59 dnaJ protein homolog Cucumis sativus 75-79 1999271-2 1991 A peptide corresponding to the COOH-terminal domain of the GLUT1 glucose transporter (Thr-Pro-Glu-Glu-Leu-Phe-His-Pro-Leu-Gly-Ala-Asp-Ser-Gln-Val) was synthesized and conjugated to keyhole limpet hemocyanin through the NH2-terminal of the peptide. Histidine 110-113 solute carrier family 2 member 1 Homo sapiens 59-64 1900206-8 1991 The activity of this enzyme was decreased by the serine esterase inhibitors phenylmethyl-sulfonyl fluoride and N-tosyl-L-phenylalanine chloromethyl ketone and by the histidine modifier diethyl pyrocarbonate, suggesting that CoA-IT may belong to a family of acyltransferase enzymes typified by LCAT. Histidine 166-175 lecithin-cholesterol acyltransferase Homo sapiens 293-297 1824702-0 1991 Disruption of an ATP-dependent isomerization of the recA protein by mutation of histidine 163. Histidine 80-89 RAD51 recombinase Homo sapiens 52-56 1824702-1 1991 We have used site-directed mutagenesis to replace histidine 163 of the recA polypeptide with an alanine residue. Histidine 50-59 RAD51 recombinase Homo sapiens 71-75 1983814-10 1991 However, iron chelates of ascorbate, fructose, and histidine donated iron to mucin at neutral pH. Histidine 51-60 solute carrier family 13 member 2 Rattus norvegicus 77-82 1846136-10 1991 A comparison of the arrangement of heme binding sites and coordinated histidines in the amino acid sequences of cytochrome c3 and Hmc from D. vulgaris Hildenborough suggests that the latter contains three cytochrome c3-like domains. Histidine 70-80 hmcA Desulfovibrio vulgaris str. Hildenborough 130-133 1699942-3 1990 The cDNA encodes a proline-, serine-, and glycine-rich nuclear protein designated Nup475 of 319 amino acids that contains two tandemly repeated cysteine- and histidine-containing sequences (CX8CX5CX3H) suggestive of a novel heavy metal-binding domain. Histidine 158-167 zinc finger protein 36 Mus musculus 82-88 2271531-10 1990 Insulin mutants [B25-Asp]insulin and [B25-His]insulin display 16- and 20-fold decreases in IDE affinity versus wild-type insulin. Histidine 42-45 insulin degrading enzyme Homo sapiens 91-94 10649380-0 2000 How Strong Is the Coordination Bond between a Histidine Tag and Ni - Nitrilotriacetate? Histidine 46-55 long intergenic non-protein coding RNA 1194 Homo sapiens 56-59 9373320-13 1996 However, when expressed together with the consensus motif His-Arg, as in HRWWXXXX or in HRXKWWXX, binding of these peptides to Fab 2925 increased as compared to peptides expressing the His-Arg motif only. Histidine 58-61 FA complementation group B Homo sapiens 127-130 8662772-5 1996 Using a degenerate phosphopeptide library screen, we show that the PTB domain of ShcC preferentially binds the sequence His-hydrophobic-Asn/hydrophobic-Asn-Pro-Ser/Thr-Tyr(P). Histidine 120-123 SHC adaptor protein 3 Homo sapiens 81-85 2196279-4 1990 By directly sequencing genomic DNA amplified by polymerase chain reaction, we have demonstrated that both patients are heterozygous for the same point mutation converting codon 65 from an arginine (CGT) to a histidine (CAT) codon. Histidine 208-217 UDP glycosyltransferase 8 Homo sapiens 198-201 2158889-17 1990 The histidine residue at position 132 of rat heme oxygenase-1 and the residues (Lys128-Arg136) flanking His132 were conserved in all three enzymes, as well as in the corresponding portion of a fourth less highly similar rat enzyme, heme oxygenase-2. Histidine 4-13 heme oxygenase 1 Rattus norvegicus 45-61 2155655-9 1990 Based on these considerations, Glu-68 may be within the interaction sphere of cytochrome f, suggesting that cytochrome f may donate electrons to plastocyanin at either Tyr-83 or His-87. Histidine 178-181 apocytochrome f precursor Spinacia oleracea 78-90 2155655-9 1990 Based on these considerations, Glu-68 may be within the interaction sphere of cytochrome f, suggesting that cytochrome f may donate electrons to plastocyanin at either Tyr-83 or His-87. Histidine 178-181 apocytochrome f precursor Spinacia oleracea 108-120 2347667-8 1990 These experiments evaluated the effectiveness of encapsulated histidase in depleting histidine. Histidine 85-94 histidine ammonia-lyase Homo sapiens 62-71 1692573-3 1990 Effective separations of fetal-derived AFP variants was accomplished within 20 min under mild conditions with an L-histidine buffer. Histidine 113-124 alpha fetoprotein Mus musculus 39-42 34739847-8 2021 Using different PCSK9 constructs, we show that PCSK9 interacts with DACT2 through its Cys-His-rich domain (CHRD) domain. Histidine 90-93 dishevelled binding antagonist of beta catenin 2 Homo sapiens 68-73 8626468-11 1996 2) Substitution of either His residue in HEXXH leads to apparent intracellular degradation of the mutant products, pointing to a role for zinc binding in in vivo stability of gp63. Histidine 26-29 leishmanolysin like peptidase Homo sapiens 175-179 8809190-1 1996 Using photoaffinity labeling with the progesterone analogue, progesterone-11 alpha-hemisuccinate-(2-[125I]-iodohistamine) ([125I]-his-PG), we identified and characterized a protein band of MW 29 kDa (p29) in mouse cerebellar membranes whose labeling is markedly inhibited by estrogens. Histidine 111-114 SYF2 homolog, RNA splicing factor (S. cerevisiae) Mus musculus 200-203 8638712-8 1996 We concluded that gastrin, acting through "gastrin/CCK-B type" receptors coupled to PTX-sensitive G protein, exerts a short-term regulation of histamine synthesis in gastric ECL cells by increasing both the affinity of HDC for L-histidine and the number of active enzyme molecules. Histidine 227-238 histidine decarboxylase Oryctolagus cuniculus 219-222 8785300-1 1996 Actin labeled at Gln-41 with dansyl ethylenediamine (DED) via transglutaminase reaction was used for monitoring the interaction of myosin subfragment 1 (S1) with the His-40-Gly-42 site in the 38-52 loop on F-actin. Histidine 166-169 myosin heavy chain 14 Homo sapiens 131-137 34948007-5 2021 The results provided the possibility to compare the Ni(II) binding properties between N-terminal and histidine-rich part of Hpn-like protein and between N-terminal parts of two Hpn-like strains, which differ mainly in the number of glutamine residues. Histidine 101-110 hepsin Homo sapiens 124-127 8617783-3 1996 The combined effect of two histidine mutants, E30H and Q62H, gave thioredoxin the capacity to bind to nickel ions immobilized on iminodiacetic acid- and nitrilotriacetic acid-Sepharose resins. Histidine 27-36 thioredoxin Homo sapiens 66-77 8617783-4 1996 Even though these two histidines were more than 30 residues apart in thioredoxin"s primary sequence, they were found to satisfy the geometric constraints for metal ion coordination as a result of the thioredoxin tertiary fold. Histidine 22-32 thioredoxin Homo sapiens 69-80 8617783-4 1996 Even though these two histidines were more than 30 residues apart in thioredoxin"s primary sequence, they were found to satisfy the geometric constraints for metal ion coordination as a result of the thioredoxin tertiary fold. Histidine 22-32 thioredoxin Homo sapiens 200-211 8617783-5 1996 A third histidine mutation, S1H, provided additional metal ion chelation affinity, but the native histidine at position 6 of thioredoxin was found not to participate in binding. Histidine 98-107 thioredoxin Homo sapiens 125-136 8617783-6 1996 All of the histidine mutants exhibited decreased thermal stability as compared with wild-type thioredoxin; however, the introduction of an additional mutation, D26A, increased their melting temperatures beyond that of wild-type thioredoxin. Histidine 11-20 thioredoxin Homo sapiens 94-105 8617783-6 1996 All of the histidine mutants exhibited decreased thermal stability as compared with wild-type thioredoxin; however, the introduction of an additional mutation, D26A, increased their melting temperatures beyond that of wild-type thioredoxin. Histidine 11-20 thioredoxin Homo sapiens 228-239 8617783-7 1996 The metal chelating abilities of these histidine mutants of thioredoxin were successfully utilized for convenient purifications of human interleukin-8 and -11 expressed in E. coli as soluble thioredoxin fusion proteins. Histidine 39-48 thioredoxin Homo sapiens 60-71 34782676-3 2021 EgtD, an S-adenosylmethionine-dependent methyltransferase (AdoMet), catalyzes the trimethylation of L-Histidine to initiate EGT biosynthesis and this reaction has been shown to be essential for EGT production in mycobacteria and for long-term infection of murine macrophages by M. tb. Histidine 100-111 methionine adenosyltransferase I, alpha Mus musculus 9-57 34782676-3 2021 EgtD, an S-adenosylmethionine-dependent methyltransferase (AdoMet), catalyzes the trimethylation of L-Histidine to initiate EGT biosynthesis and this reaction has been shown to be essential for EGT production in mycobacteria and for long-term infection of murine macrophages by M. tb. Histidine 100-111 methionine adenosyltransferase I, alpha Mus musculus 59-65 34117217-6 2021 Our data suggest that TRAF2 binds to PVQE motif residing in between the PEST and histidine repeat domain (HRD) of DYRK1A protein, and mediates K63-linked ubiquitination of DYRK1A. Histidine 81-90 TNF receptor associated factor 2 Homo sapiens 22-27 34792001-6 2021 His-affinity resin, ion exchange and gel filtration chromatography were used to purify NEK7. Histidine 0-3 NIMA related kinase 7 Homo sapiens 87-91 35529437-7 2022 In particular, l-histidine (fold change = 91.5, p = 0.01) showed significantly higher levels in the immediate HSR group, while myristicin (fold change = 0.218, p = 0.003), urocanic acid (fold change = 0.193, p = 0.007), and d-aldose (fold change = 0.343, p = 0.003) showed significantly lower levels in the same group. Histidine 15-26 HSR Homo sapiens 110-113 35529437-11 2022 These findings suggested that l-histidine can be a potential biomarker for PLD-induced HSR. Histidine 30-41 HSR Homo sapiens 87-90 35531278-0 2022 Deletion of Non-histidine Domains of Histidine Kinase CHK1 Diminishes the Infectivity of Candida albicans in an Oral Mucosal Model. Histidine 16-25 checkpoint kinase 1 Mus musculus 54-58 35156774-6 2022 Docking study of this compound demonstrated that compound 7o interacted with critical histidine residues within tyrosinase active site. Histidine 86-95 tyrosinase Homo sapiens 112-122 8617783-7 1996 The metal chelating abilities of these histidine mutants of thioredoxin were successfully utilized for convenient purifications of human interleukin-8 and -11 expressed in E. coli as soluble thioredoxin fusion proteins. Histidine 39-48 thioredoxin Homo sapiens 191-202 8652590-3 1996 The lower axial ligand to the cobalt in free methylcobalamin is the dimethylbenzimidazole nucleotide substituent of the corrin ring; when methylcobalamin binds to methionine synthase, the ligand is replaced by histidine 759, which in turn is linked by hydrogen bonds to aspartate 757 and thence to serine 810. Histidine 210-219 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 163-182 35524873-6 2022 Soluble His-CCL5 was successfully expressed with 0.1 mmol/L of isopropyl-beta-D-1-tiogalactopiranoside at 25 C and purified by affinity chromatography. Histidine 8-11 C-C motif chemokine ligand 5 Homo sapiens 12-16 35077997-1 2022 Protein disulfide isomerase (PDI), an oxidoreductase, possesses two vicinal cysteines in the -Cys-Gly-His-Cys-motif that either form a disulfide bridge (S-S) or exist in a sulfhydryl form (-SH), forming oxidized or reduced PDI, respectively. Histidine 102-105 thioredoxin reductase 1 Homo sapiens 38-52 35370775-2 2022 In addition, we found colocalization of NPGL, NPGM, and histidine decarboxylase (HDC; histamine-producing enzyme) in same neurons of the medial mammillary nucleus of the hypothalamus. Histidine 56-65 histidine decarboxylase Gallus gallus 81-84 35229720-2 2022 Histamine, a monoamine neurotransmitter, is synthesized through decarboxylation of histidine by histidine decarboxylase (Hdc). Histidine 83-92 Histidine decarboxylase Drosophila melanogaster 96-119 35229720-2 2022 Histamine, a monoamine neurotransmitter, is synthesized through decarboxylation of histidine by histidine decarboxylase (Hdc). Histidine 83-92 Histidine decarboxylase Drosophila melanogaster 121-124 2684616-7 1989 From these results it is concluded that histidine at position 7 of GLP-1 as a free N-terminal amino acid is very important in GLP-1"s insulinotropic activity and probably in glucagon-inhibiting activity, and that C-terminal amidation and three C-terminal amino acids are less important for these activities. Histidine 40-49 glucagon Rattus norvegicus 67-72 2684616-7 1989 From these results it is concluded that histidine at position 7 of GLP-1 as a free N-terminal amino acid is very important in GLP-1"s insulinotropic activity and probably in glucagon-inhibiting activity, and that C-terminal amidation and three C-terminal amino acids are less important for these activities. Histidine 40-49 glucagon Rattus norvegicus 126-131 2517482-0 1989 The histidines reacting with ethoxyformic anhydride in porcine pancreatic lipase: their relationships with enzyme activity. Histidine 4-14 pancreatic lipase Homo sapiens 63-80 2517482-1 1989 The activities of porcine pancreatic lipase (449 amino acid residues) toward two different substrates, p-nitrophenylacetate and tributyrylglycerol, and their dependence on histidine ethoxyformylation were studied. Histidine 172-181 pancreatic lipase Homo sapiens 26-43 2804130-0 1989 Chemical properties of the histidine residue of secretin: evidence for a specific intramolecular interaction. Histidine 27-36 secretin Homo sapiens 48-56 2804130-1 1989 Secretin has a single histidine residue located at the amino terminus which plays a crucial role in its biological activity. Histidine 22-31 secretin Homo sapiens 0-8 2777799-6 1989 The distal histidine in this subunit inhibits the bimolecular rate of binding of both O2 and CO, sterically hinders bound CO and methyl isocyanide, and stabilizes bound O2 by hydrogen bonding. Histidine 11-20 immunoglobulin kappa variable 1D-39 Homo sapiens 86-95 2514797-0 1989 Role of histidine 64 in the catalytic mechanism of human carbonic anhydrase II studied with a site-specific mutant. Histidine 8-17 carbonic anhydrase 2 Homo sapiens 57-78 2514797-1 1989 To test the hypothesis that histidine 64 in the active site of human carbonic anhydrase II functions as a proton-transfer group in the catalysis of CO2 hydration, we have studied a site-specific mutant having histidine 64 replaced by alanine, which cannot transfer protons. Histidine 28-37 carbonic anhydrase 2 Homo sapiens 69-90 2605694-1 1989 A heptadecapeptide, H-Arg-Lys-Ala-Val-Tyr-Val-Glu-Leu-Tyr-Leu-Gln-Ser-Leu-Thr-Ala-Glu-His-OH , corresponding to amino acids 32 to 48 of human splenin (hSP) and an analog in which the amino acid residue at position 34 is changed from Ala to Glu, were synthesized. Histidine 86-89 heat shock protein 90 beta family member 2, pseudogene Homo sapiens 151-154 2545905-4 1989 The protein predicted by this reading frame (STP; saimiri transformation-associated protein) has a highly hydrophobic stretch of 26 amino acids sufficient for a membrane-spanning domain near its carboxy terminus; this domain is immediately preceded by a sequence appropriate for formation of a metal-binding domain (His X2 His X6 Cys X2 Cys, where Xs are other amino acids). Histidine 316-319 thyroid hormone receptor interactor 10 Homo sapiens 45-48 2787670-0 1989 The microheterogeneity of desialylated alpha 1-antichymotrypsin: the occurrence of two amino-terminal isoforms, one lacking a His-Pro dipeptide. Histidine 126-129 serpin family A member 3 Homo sapiens 39-63 2473157-6 1989 The encoded amino acid sequence of ECP shows 66% identity to that of EDN and 31% identity to that of human pancreatic ribonuclease, including conservation of the essential structural cysteine and cataytic lysine and histidine residues. Histidine 216-225 ribonuclease A family member 3 Homo sapiens 35-38 2662962-2 1989 IMAC of proteins on transition metals (Co, Ni, Cu, Zn) can be rationalized in terms of the coordination of histidine residues. Histidine 107-116 C-C motif chemokine ligand 26 Homo sapiens 0-4 2742853-6 1989 Carboxymethylation of His-13 or His-114 with bromoacetate increases the Ki value 15-fold, and oxidation of Trp-89 by means of dimethyl sulfoxide and hydrochloric acid increases it 2.4-fold, suggesting that these residues also form part of the contact region with PRI. Histidine 22-25 ribonuclease/angiogenin inhibitor 1 Homo sapiens 263-266 2742853-6 1989 Carboxymethylation of His-13 or His-114 with bromoacetate increases the Ki value 15-fold, and oxidation of Trp-89 by means of dimethyl sulfoxide and hydrochloric acid increases it 2.4-fold, suggesting that these residues also form part of the contact region with PRI. Histidine 32-35 ribonuclease/angiogenin inhibitor 1 Homo sapiens 263-266 2742853-9 1989 These results indicate that PRI inhibition minimally involves the three residues critical for the activity of angiogenin--Lys-40, His-13, and His-114--and to a lesser extent its single tryptophan, Trp-89. Histidine 130-133 ribonuclease/angiogenin inhibitor 1 Homo sapiens 28-31 2742853-9 1989 These results indicate that PRI inhibition minimally involves the three residues critical for the activity of angiogenin--Lys-40, His-13, and His-114--and to a lesser extent its single tryptophan, Trp-89. Histidine 142-145 ribonuclease/angiogenin inhibitor 1 Homo sapiens 28-31 2706085-11 1989 These results indicate that some of the cysteine residues in the polypeptide chain of THP can be replaced by histidine, suggesting a role of some cysteins in metal binding rather than intramolecular stabilization. Histidine 109-118 uromodulin Homo sapiens 86-89 2645140-6 1989 The affinity of the mutant E. coli SSB proteins for single-stranded DNA decreased in the order Trp greater than Phe (wild-type) greater than Tyr greater than Leu greater than His greater than Val greater than Ser, leading to the conclusion that position 60 is a site of hydrophobic interaction of the protein with DNA. Histidine 175-178 single-stranded DNA-binding protein Escherichia coli 35-38 2591200-2 1989 Chemical modification of essential serine, histidine and cysteine residues of porcine LCAT were accompanied by loss of enzymatic activity. Histidine 43-52 lecithin-cholesterol acyltransferase Homo sapiens 86-90 3199133-1 1988 One equivalent of Fe3+ -mesoporphyrin (heme) is coordinated by two axial histidine ligands to a preferred site on histidine-rich glycoprotein (HRG). Histidine 73-82 histidine rich glycoprotein Homo sapiens 114-141 3199133-1 1988 One equivalent of Fe3+ -mesoporphyrin (heme) is coordinated by two axial histidine ligands to a preferred site on histidine-rich glycoprotein (HRG). Histidine 73-82 histidine rich glycoprotein Homo sapiens 143-146 3220658-2 1988 The pKa"s of the three histidine residues in a proline-rich glycoprotein from human parotid saliva (PRG) were determined by 360 MHz proton n.m.r. Histidine 23-32 proline rich protein BstNI subfamily 3 Homo sapiens 100-103 3220658-7 1988 Exchange lifetime data and previously reported hydrogen----deuterium exchange experiments suggest that the PRG histidine N tau H protons are not involved in hydrogen-bonds. Histidine 111-120 proline rich protein BstNI subfamily 3 Homo sapiens 107-110 3292705-11 1988 It is concluded that LHRH degradation is primarily initiated by the membrane-bound form of endopeptidase-24.15 to yield pGlu-His-Trp-Ser-Tyr and to a lesser extent by endopeptidase-24.11 to yield pGlu-His-Trp-Ser-Tyr-Gly. Histidine 125-128 thimet oligopeptidase 1 Mus musculus 91-110 3410637-2 1988 The titration curves of the C-2 histidine protons of bovine pancreatic ribonuclease A in the presence of several dideoxynucleoside monophosphates (dNpdN) were studied by means of proton nuclear magnetic resonance at 270 MHz in order to obtain information on the ligand--RNase A interaction. Histidine 32-41 complement C2 Bos taurus 28-31 3410637-3 1988 The changes in the chemical shift and pKs of the C-2 proton resonances of His-12, -48, -119 in the complexes RNase A--dNpdN were smaller than those previously found when the enzyme interacted with mononucleotides. Histidine 74-77 complement C2 Bos taurus 49-52 3348809-3 1988 On the other hand, we determined the primary structure of human H-protein from the amino terminal Ser by the 12th Val, including a hexapeptide, -Glu-Lys-His-Glu-Trp-Val-. Histidine 153-156 myosin binding protein H Homo sapiens 64-73 3126084-1 1988 To test the hypothesis that histidine 64 in carbonic anhydrase II has a crucial role as a "proton shuttle group" during catalysis of CO2-HCO3- interconversion, this residue was replaced by lysine, glutamine, glutamic acid and alanine by site-directed mutagenesis. Histidine 28-37 carbonic anhydrase 2 Homo sapiens 44-65 3276679-13 1988 Cleavages were found between B-9 and B-10 (Ser-His), B-10 and B-11 (His-Leu), B-14 and B-15 (Ala-Leu), B-13 and B-14 (Glu-Ala), B-16 and B-17 (Tyr-Leu), B-24 and B-25 (Phe-Phe), and B-25 and B-26 (Phe-Tyr). Histidine 47-50 NADH:ubiquinone oxidoreductase subunit A3 Homo sapiens 29-41 2821259-7 1987 Furthermore, pH dependency studies showed that, at lower pH, change in the affinities for the PBR ligands is a property of the receptor, substantiating the hypothesis that a histidine moiety on the PBR is the most likely site for covalent bond formation, whereas, at higher pH, the observed changes in affinities can be attributed to properties of the compounds. Histidine 174-183 translocator protein Homo sapiens 94-97 2821259-7 1987 Furthermore, pH dependency studies showed that, at lower pH, change in the affinities for the PBR ligands is a property of the receptor, substantiating the hypothesis that a histidine moiety on the PBR is the most likely site for covalent bond formation, whereas, at higher pH, the observed changes in affinities can be attributed to properties of the compounds. Histidine 174-183 translocator protein Homo sapiens 198-201 3305492-11 1987 Acyl-peptide hydrolase appears to be a serine protease utilizing a charge relay system involving serine, histidine, and, probably, a carboxyl group(s). Histidine 105-114 acylaminoacyl-peptide hydrolase Rattus norvegicus 0-22 3624221-5 1987 The 1H and 13C nuclear magnetic resonance data indicated that imidazole C-2 of histidine is linked to C-6 of norleucine (epsilon-deaminated lysine residue) which in turn is linked to the C-6 amino group of hydroxylysine. Histidine 79-88 complement C2 Bos taurus 72-75 3112579-8 1987 All four mutations that altered invariant cysteine or histidine residues led to an adr1 null phenotype. Histidine 54-63 DNA-binding transcription factor ADR1 Saccharomyces cerevisiae S288C 83-87 3103690-4 1987 We now confirm the involvement of serine and histidine in catalysing the phospholipase A2 action of lecithin-cholesterol acyltransferase by demonstrating the inhibition of this activity by phenylboronic acid (Ki = 1.23 mM) and m-aminophenylboronic acid (Ki = 2.32 mM), inhibitors of known serine/histidine hydrolases. Histidine 45-54 lecithin-cholesterol acyltransferase Homo sapiens 100-136 3029126-3 1987 The activated N-ras clone has an AT to TA transversion at the third position of codon 61 which results in the insertion of histidine instead of glutamine. Histidine 123-132 GTPase NRas Cavia porcellus 14-19 3818601-4 1987 Based upon current models for the secondary structure of cytochrome b, the altered amino acid lies in close proximity to one of the invariant histidine residues involved in binding the heme groups. Histidine 142-151 mitochondrially encoded cytochrome b Homo sapiens 57-69 3548423-1 1987 The human vasoactive intestinal polypeptide (VIP) precursor contains a sequence, a peptide with an N-terminal histidine and C-terminal methionine (PHM), which is 93% homologous to the porcine intestinal peptide, (PHI) a peptide having N-terminal histidine and C-terminal isoleucine amide, suggesting that PHI could be a product of the porcine VIP precursor. Histidine 246-255 peptidylglycine alpha-amidating monooxygenase Homo sapiens 147-150 20501143-1 1987 Specific binding sites for thyrotropin-releasing hormone (TRH) were labelled with the potent analog, [(3)H] (3-Me-His(2))TRH, in the brain and spinal cord of the mutant mouse spastic and nonafflicted littermate controls. Histidine 114-117 thyrotropin releasing hormone Mus musculus 27-56 20501143-1 1987 Specific binding sites for thyrotropin-releasing hormone (TRH) were labelled with the potent analog, [(3)H] (3-Me-His(2))TRH, in the brain and spinal cord of the mutant mouse spastic and nonafflicted littermate controls. Histidine 114-117 thyrotropin releasing hormone Mus musculus 58-61 20501143-1 1987 Specific binding sites for thyrotropin-releasing hormone (TRH) were labelled with the potent analog, [(3)H] (3-Me-His(2))TRH, in the brain and spinal cord of the mutant mouse spastic and nonafflicted littermate controls. Histidine 114-117 thyrotropin releasing hormone Mus musculus 121-124 3518635-3 1986 A comparison with other known insulin structures suggests that cat insulin has an uncommon property: it appears to be the only insulin found so far with His at position A18. Histidine 153-156 immunoglobulin kappa variable 2-29 Homo sapiens 169-172 3707913-3 1986 The microenvironments of the histidines in three isoforms of Ca(II)-bound parvalbumin (carp, pI = 4.25; pike, pI = 5.00; rat, pI = 5.50) have been examined with 1H NMR techniques to probe their protonation characteristics and photochemically induced dynamic nuclear polarizability (photo-CIDNP). Histidine 29-39 parvalbumin Rattus norvegicus 74-85 3707913-8 1986 Although the crystal structure of carp parvalbumin indicates that His-26 is exposed to solvent [Kretsinger, R. H., & Nockolds, C. E. (1973) J. Biol. Histidine 66-69 parvalbumin Rattus norvegicus 39-50 3707913-11 1986 In contrast, His-48 in rat parvalbumin and His-106 in pike III parvalbumin show dramatic photo-CIDNP enhancements of their C2H, C5H, and beta-CH2 1H NMR resonances. Histidine 13-16 parvalbumin Rattus norvegicus 27-38 3707913-11 1986 In contrast, His-48 in rat parvalbumin and His-106 in pike III parvalbumin show dramatic photo-CIDNP enhancements of their C2H, C5H, and beta-CH2 1H NMR resonances. Histidine 13-16 parvalbumin Rattus norvegicus 63-74 3707913-11 1986 In contrast, His-48 in rat parvalbumin and His-106 in pike III parvalbumin show dramatic photo-CIDNP enhancements of their C2H, C5H, and beta-CH2 1H NMR resonances. Histidine 43-46 parvalbumin Rattus norvegicus 63-74 3956484-7 1986 It is proposed that the Ser-Phe combination present in L16, L11 and L6 is involved in transesterification in addition to the single histidine in L16. Histidine 132-141 immunoglobulin kappa variable 1-6 Homo sapiens 60-63 3080348-4 1986 By correlating the size of the peptide fragments released by these enzymes with the known sequence of aldolase, evidence has been provided that cleavage of His-359 and/or Tyr-361 lead to the loss of FBP activity, while further cleavage of up to six amino acids begin to affect activity against F1P, as well. Histidine 156-159 fructose-bisphosphatase 1 Homo sapiens 199-202 4055729-1 1985 The flavoenzymes dimethylglycine dehydrogenase (EC 1.5.99.2) and sarcosine dehydrogenase (EC 1.5.99.1) contain covalently bound FAD linked via the 8 alpha-position of the isoalloxazine ring to the imidazole N(3) of a histidine residue (Cook, R. J., Misono, K. S., and Wagner, C. (1984) J. Biol. Histidine 217-226 dimethylglycine dehydrogenase Rattus norvegicus 17-46 3161731-10 1985 The amino acid compositions of GP Ib beta and GP IX were similar but showed marked differences in the levels of glutamic acid, alanine, histidine and arginine. Histidine 136-145 glycoprotein Ib platelet subunit beta Homo sapiens 31-41 3926517-2 1985 injection of histidyl-proline diketopiperazine [cyclo (His-Pro)], an active metabolite of thyrotropin-releasing hormone (TRH) in mice produced an antinociceptive effect in a dose-dependent manner as measured in four antinociceptive tests; tail-pressure, tail-flick, hot-plate and acetic acid writhing. Histidine 55-58 thyrotropin releasing hormone Mus musculus 90-119 3926517-2 1985 injection of histidyl-proline diketopiperazine [cyclo (His-Pro)], an active metabolite of thyrotropin-releasing hormone (TRH) in mice produced an antinociceptive effect in a dose-dependent manner as measured in four antinociceptive tests; tail-pressure, tail-flick, hot-plate and acetic acid writhing. Histidine 55-58 thyrotropin releasing hormone Mus musculus 121-124 3986189-8 1985 As with the parent HRG molecule, interaction of the peptide with heme and metals is dependent on pH and intact histidine residues. Histidine 111-120 histidine rich glycoprotein Homo sapiens 19-22 2581330-3 1985 Three of the antibodies directly inhibited the amidolytic activity of t-PA and the two most effective also bound near the active site histidine residue as determined by competition experiments using active site blocking agents. Histidine 134-143 chromosome 20 open reading frame 181 Homo sapiens 70-74 2887178-1 1985 Catabolism of histidine was investigated in 24 patients with different speech and language disorders and with significantly low histidase activity in stratum corneum. Histidine 14-23 histidine ammonia-lyase Homo sapiens 128-137 2887178-3 1985 Biochemical investigation of these patients after loading with L-histidine led to the conclusions that low histidase activity in stratum corneum was connected with: disturbances in folic acid metabolism (2 cases); "atypical histidinemia" (1 case); heterozygotes of histidinemia (2 cases); normal liver histidine metabolism but abnormal in other tissues (18 cases); previously unknown error of histidine metabolism (1 case). Histidine 63-74 histidine ammonia-lyase Homo sapiens 107-116 2887178-3 1985 Biochemical investigation of these patients after loading with L-histidine led to the conclusions that low histidase activity in stratum corneum was connected with: disturbances in folic acid metabolism (2 cases); "atypical histidinemia" (1 case); heterozygotes of histidinemia (2 cases); normal liver histidine metabolism but abnormal in other tissues (18 cases); previously unknown error of histidine metabolism (1 case). Histidine 65-74 histidine ammonia-lyase Homo sapiens 107-116 2887178-3 1985 Biochemical investigation of these patients after loading with L-histidine led to the conclusions that low histidase activity in stratum corneum was connected with: disturbances in folic acid metabolism (2 cases); "atypical histidinemia" (1 case); heterozygotes of histidinemia (2 cases); normal liver histidine metabolism but abnormal in other tissues (18 cases); previously unknown error of histidine metabolism (1 case). Histidine 224-233 histidine ammonia-lyase Homo sapiens 107-116 3156581-4 1985 Histidine residues are the primary target for the sensitized photo-oxidation that inactivates lipoamide dehydrogenase and alcohol dehydrogenase. Histidine 0-9 aldo-keto reductase family 1 member A1 Homo sapiens 122-143 3925401-1 1985 Chemical modification studies on homogeneous bovine lens aldose reductase using diethylpyrocarbonate, phenylglyoxal, butanedione, N-ethylmaleimide and p-chloromercuribenzoate indicate that histidine and arginine residues located at or near the nucleotide binding site may be important in binding or orientation of the NADPH, and that NADPH oxidation with glucose requires protein thiol. Histidine 189-198 aldose reductase Bos taurus 57-73 6432048-6 1984 The mechanism of interaction between chloride and the enzyme is discussed, and a model is proposed in which chloride interferes the tyrosinase activity by displacing a catalytically important ligand, probably a histidine residue of the side-chain, from the copper at the enzyme-active site. Histidine 211-220 tyrosinase Homo sapiens 132-142 6432037-0 1984 Paramagnetic 1H and 13C NMR studies on cobalt-substituted human carbonic anhydrase I carboxymethylated at active site histidine-200: molecular basis for the changes in catalytic properties induced by the modification. Histidine 118-127 carbonic anhydrase 1 Homo sapiens 64-84 6086335-12 1984 Since this section contains the catalytic residues such as His-36 and Asp-93, we conclude that AK1 can serve as a three-dimensional model of AK2 in mechanistic and drug-designing studies. Histidine 59-62 adenylate kinase 1 Bos taurus 95-98 6689270-12 1983 Redox titration of the modified reductase with NADPH and with reduced ferredoxin suggested that the second histidine might be located in the electron pathway between FAD and ferredoxin. Histidine 107-116 2,4-dienoyl-CoA reductase 1 Homo sapiens 47-52 6687316-1 1983 In this report we describe experiments showing that diethylpyrocarbonate, a histidine selective reagent, inhibits progestin binding to the chick oviduct progesterone receptor. Histidine 76-85 progesterone receptor Gallus gallus 153-174 6687316-2 1983 Because this inhibition is reversed by hydroxylamine, we suggest that the chick oviduct progesterone receptor contains one or more histidine residues that regulate progestin binding. Histidine 131-140 progesterone receptor Gallus gallus 88-109 6848456-5 1983 Both NIF polypeptides contain one cysteine and one methionine, lack isoleucine, tyrosine and phenylalanine, and are rich in histidine and proline. Histidine 124-133 S100 calcium binding protein A9 Homo sapiens 5-8 7138844-7 1982 These binding constants and the predicted response of the active-site histidine pK1/2 values to anion binding are shown to agree with experimental determinations. Histidine 70-79 prokineticin 1 Homo sapiens 80-85 6289876-1 1982 The titration curves of the C-2 histidine protons of RNase A and of derivative II--a covalent derivative obtained by reaction of the enzyme with the halogenated nucleotide 9-beta-D-ribofuranosyl-6-chloropurine 5"-phosphate--in the presence of a number of purine nucleosides, nucleoside monophosphates, and nucleoside diphosphates were studied by means of proton nuclear magnetic resonance at 270 MHz. Histidine 32-41 complement C2 Bos taurus 28-31 6280031-7 1982 The interaction of the charge of this His with the negatively charged group of Cyt c is necessary, probably for the proper arrangement of other interactions in the active complex, because the deprotonation of His-GHl in the studied pH interval decreases the rate of the process by more than one order of magnitude. Histidine 38-41 growth hormone 2 Homo sapiens 213-216 6280031-7 1982 The interaction of the charge of this His with the negatively charged group of Cyt c is necessary, probably for the proper arrangement of other interactions in the active complex, because the deprotonation of His-GHl in the studied pH interval decreases the rate of the process by more than one order of magnitude. Histidine 209-212 growth hormone 2 Homo sapiens 213-216 6921142-5 1981 The results indicate that TosLysCH2Cl inactivates kallikrein activity and support the notion that reactive histidine residue(s) participates in the active center of Kallikrein for catalysis. Histidine 107-116 kallikrein related peptidase 4 Homo sapiens 165-175 7239137-2 1981 It shares a common C-terminal decapeptide homology with bombesin (except for a His/Gln interchange at residue 8 from C-terminus). Histidine 79-82 gastrin releasing peptide Homo sapiens 56-64 6115414-12 1981 It seems possible that glucose-6-phosphate isomerase, triose phosphate isomerase and pyruvate kinase all contain a histidine and a glutamate residue at the active site. Histidine 115-124 glucose-6-phosphate isomerase Sus scrofa 23-52 7373889-0 1980 [Measurement of histidase activity in the stratum corneum with radioactively labelled L-histidine (author"s transl)]. Histidine 86-97 histidine ammonia-lyase Homo sapiens 16-25 518870-8 1979 There are two possible implications of this result: (1) the iron atom spin state is not the only major factor in the determination of its position with respect to the heme plane or (2) the change with conformation of the protein force exerted by the proximal histidine on the iron atom (for an iron to heme-plane displacement of less than 0.3 A) is less than 50% of that expected from simple models in which this motion is responsible for cooperativity. Histidine 259-268 spindlin 1 Homo sapiens 70-74 38849-0 1979 Affinity labeling of histidine and lysine residue in the adenosine deaminase substrate binding site. Histidine 21-30 adenosine deaminase Homo sapiens 57-76 36073-17 1979 We propose that the observed inhibition of pyruvate carboxylase by formiminoglutamate may account in part for the toxic effect of excess histidine. Histidine 137-146 pyruvate carboxylase Rattus norvegicus 43-63 430230-0 1979 Effect of induction of histidase on histidine metabolism in vivo. Histidine 36-45 histidine ammonia-lyase Homo sapiens 23-32 80232-1 1978 The carbethoxylation of prostatic acid phosphatase (orthophosphoric-monoester phosphohydrolase (acid optimum), EC 3.1.3.2) was accompanied by modification of histidine residues and the inactivation of the enzyme. Histidine 158-167 acid phosphatase 3 Homo sapiens 24-50 667106-4 1978 This observation was interpreted in terms of the stronger interaction between proximal histidine and ferric heme iron in methemoglobin than in metmyoglobin. Histidine 87-96 hemoglobin subunit gamma 2 Homo sapiens 121-134 23288-0 1977 Nuclear-magnetic-resonance study of the histidine residues of S-peptide and S-protein and kinetics of 1H-2H exchange of ribonuclease A. Histidine 40-49 vitronectin Homo sapiens 76-85 23288-10 1977 The reassignment of the three C-2 histidine resonances of S-protein is confirmed by partial deuteration studies. Histidine 34-43 vitronectin Homo sapiens 58-67 23288-12 1977 The S-protein is less stable to acid than RNase-A since the former, but not the latter, shows evidence of reversible denaturation at pH 3 and 26 degrees C. His-48 in S-protein titrates normally and has a lower pK than in RN-ase-A probably because of the absence of Asp-14, which in RN-ase-A forms a a hydrogen bond with His-48 and causes it to be inaccessible to solvent, at pH values below 9. Histidine 156-159 vitronectin Homo sapiens 4-13 23288-12 1977 The S-protein is less stable to acid than RNase-A since the former, but not the latter, shows evidence of reversible denaturation at pH 3 and 26 degrees C. His-48 in S-protein titrates normally and has a lower pK than in RN-ase-A probably because of the absence of Asp-14, which in RN-ase-A forms a a hydrogen bond with His-48 and causes it to be inaccessible to solvent, at pH values below 9. Histidine 156-159 vitronectin Homo sapiens 166-175 23288-12 1977 The S-protein is less stable to acid than RNase-A since the former, but not the latter, shows evidence of reversible denaturation at pH 3 and 26 degrees C. His-48 in S-protein titrates normally and has a lower pK than in RN-ase-A probably because of the absence of Asp-14, which in RN-ase-A forms a a hydrogen bond with His-48 and causes it to be inaccessible to solvent, at pH values below 9. Histidine 320-323 vitronectin Homo sapiens 4-13 23288-12 1977 The S-protein is less stable to acid than RNase-A since the former, but not the latter, shows evidence of reversible denaturation at pH 3 and 26 degrees C. His-48 in S-protein titrates normally and has a lower pK than in RN-ase-A probably because of the absence of Asp-14, which in RN-ase-A forms a a hydrogen bond with His-48 and causes it to be inaccessible to solvent, at pH values below 9. Histidine 320-323 vitronectin Homo sapiens 166-175 893419-2 1977 TnC was found to be a single polypeptide chain of 159 amino acid residues, including 2 residues of tyrosine and 1 each of cysteine, histidine, and proline. Histidine 132-141 tenascin Oryctolagus cuniculus 0-3 921767-1 1977 The C-2 proton of one histidine residue in bovine erythrocyte superoxide dismutase is shown to be particularly labile. Histidine 22-31 complement C2 Bos taurus 4-7 952947-9 1976 The amino acid compositions of the histidine and/or tyrosine containing peptides indicated a high degree of homology with bovine thrombin. Histidine 35-44 coagulation factor II, thrombin Bos taurus 129-137 4454-2 1976 One of the four titrating histidine ring C-2 proton resonances of bovine pancreatic ribonuclease has been assigned to histidine residue 12. Histidine 26-35 complement C2 Bos taurus 41-44 4454-2 1976 One of the four titrating histidine ring C-2 proton resonances of bovine pancreatic ribonuclease has been assigned to histidine residue 12. Histidine 118-127 complement C2 Bos taurus 41-44 4454-3 1976 This was accomplished by a direct comparison of the rate of tritium incorporation into position C-2 of histidine 12 of S-peptide (residues 1 to 20) derived from ribonuclease S, with the rates of deuterium exchange of the four histidine C-2 proton resonances of ribonuclease S under the same experimental conditions. Histidine 103-112 complement C2 Bos taurus 96-99 4455-3 1976 Although S-protein contains 3 histidine residues, four discrete resonances are observed to titrate. Histidine 30-39 vitronectin Homo sapiens 9-18 4455-4 1976 One of these arises from the equivalent histidine residues of unfolded S-protein. Histidine 40-49 vitronectin Homo sapiens 71-80 4455-6 1976 Two of the resonances of the folded S-protein can be assigned to 2 of the histidine residues, 48 and 105, from the close similarity of their titration curves to those in ribonuclease. Histidine 74-83 vitronectin Homo sapiens 36-45 4455-9 1976 The low pH inflection present in the titration curve assigned to histidine residue 48 in ribonuclease is absent from this curve in S-protein. Histidine 65-74 vitronectin Homo sapiens 131-140 4455-11 1976 The third titrating resonance of native S-protein is assigned to the remaining histidine residue at position 119. Histidine 79-88 vitronectin Homo sapiens 40-49 4455-13 1976 The resonance assigned to histidine 119 is the only one significantly affected on the addition of sodium phosphate to S-protein, indicating that some degree of phosphate binding occurs. Histidine 26-35 vitronectin Homo sapiens 118-127 1033-0 1975 LYSYL oxidase dependent synthesis of a collagen cross-link containing histidine. Histidine 70-79 lysyl oxidase Homo sapiens 0-13 1150653-2 1975 The alpha,beta eliminations of NH3 from L-histidine and 4-fluoro-L-histidine by histidine ammonia-lyase appear to occur by similar mechanisms, although a large difference in Vmax for the two reactions was observed. Histidine 40-51 histidine ammonia-lyase Homo sapiens 80-103 238843-6 1975 The correct continuities for the titration curves of the histidine H-2 proton resonances have been confirmed by selective deuteration of the H-2 protons. Histidine 57-66 relaxin 2 Homo sapiens 67-70 238843-6 1975 The correct continuities for the titration curves of the histidine H-2 proton resonances have been confirmed by selective deuteration of the H-2 protons. Histidine 57-66 relaxin 2 Homo sapiens 141-144 238843-7 1975 Titration curves for the H-2 proton resonances of histidine-12 and histidine-119 of methylated RNase-A show deviations from the titration curves for the native enzyme, indicating some alteration of the active-site conformation. Histidine 50-59 relaxin 2 Homo sapiens 25-28 238843-7 1975 Titration curves for the H-2 proton resonances of histidine-12 and histidine-119 of methylated RNase-A show deviations from the titration curves for the native enzyme, indicating some alteration of the active-site conformation. Histidine 67-76 relaxin 2 Homo sapiens 25-28 238843-8 1975 In the presence of phosphate, titration curves for the H-2 proton resonances of histidine-12 and histidine-119 of methylated RNase-A indicate binding of phosphate at the active site, but these curves continue to show deviations from the titration behaviour of native RNase-A. Histidine 80-89 relaxin 2 Homo sapiens 55-58 239193-2 1975 For neurophysin I alone, a normal titration curve for the C-2 proton resonance of the lone histidine residue was obtained with an apparent ionization constant of 6.9 addition of oxytocin to a solution of neurophysin I at pH 6.5 resulted in several changes in the spectrum. Histidine 91-100 complement C2 Bos taurus 58-61 234739-3 1975 The seven resonances observed in the histidine region of the proton magnetic resonance (pmr) spectrum of human carbonic anhydrase B and reported in the preceding paper are studied in the presence of sulfonamide, azide, cyanide, and chloride inhibitors and in metal-free, cadmium substituted, cobalt substituted, and carboxymethylated forms of the enzyme. Histidine 37-46 carbonic anhydrase 2 Homo sapiens 111-131 234740-3 1975 Resonances of the histidine region of human carbonic anhydrase B have been studied by proton magnetic resonance spectroscopy in the presence of seven sulfonamide inhibitors. Histidine 18-27 carbonic anhydrase 2 Homo sapiens 44-64 24203237-0 1996 Use of combined mass spectrometry methods for the characterization of a new variant of human hemoglobin: The double mutant hemoglobin villeparisis beta77(EF1) His Tyr, beta 80 (EF4) Asn Ser. Histidine 159-162 GTP binding elongation factor GUF1 Homo sapiens 179-182 4217387-0 1974 A study of the histidine residues of human carbonic anhydrase B using 270 MHz proton magnetic resonance. Histidine 15-24 carbonic anhydrase 2 Homo sapiens 43-63 5492291-0 1970 Amino acid substitution (histidine to tyrosine) in a glucose-6-phosphate dehydrogenase variant (G6PD Hektoen) associated with over-production. Histidine 25-34 glucose-6-phosphate dehydrogenase Homo sapiens 53-86 5492291-0 1970 Amino acid substitution (histidine to tyrosine) in a glucose-6-phosphate dehydrogenase variant (G6PD Hektoen) associated with over-production. Histidine 25-34 glucose-6-phosphate dehydrogenase Homo sapiens 96-100 5460202-0 1970 Two haemoglobins Q, alpha-74 (EF3) and alpha-75 (EF4) aspartic acid to histidine. Histidine 71-80 GTP binding elongation factor GUF1 Homo sapiens 49-52 34046594-2 2021 Histidine methylation has recently attracted attention through the discovery of the human histidine methyltransferase enzymes SETD3 and METTL9. Histidine 0-9 methyltransferase like 9 Homo sapiens 136-142 34046594-2 2021 Histidine methylation has recently attracted attention through the discovery of the human histidine methyltransferase enzymes SETD3 and METTL9. Histidine 90-99 methyltransferase like 9 Homo sapiens 136-142 34036185-4 2021 We demonstrate that the presence of the six-polyhistidine tag at the amino terminus of the proteins led to a decrease in their oxidoreductase enzymatic activity compared to their non-His-tagged counterparts, when assessed using 2-hydroxyethyl disulfide as a substrate. Histidine 183-186 thioredoxin reductase 1 Homo sapiens 127-141 33942499-0 2021 Self-Assembly or Coassembly of Multiresponsive Histidine-Containing Elastin-Like Polypeptide Block Copolymers. Histidine 47-56 elastin Homo sapiens 68-75 33890127-8 2021 H-MP1 is a synthetic analog of MP1 with lysines replaced by histidines. Histidine 60-70 pitrilysin metallopeptidase 1 Homo sapiens 2-5 33888855-6 2021 Moreover, we successfully synthesized films in vitro by crosslinking a 45% His-rich CP (BmorCPR152) with laccase2 using N-acetyl- dopamine or N-beta-alanyl-dopamine as the substrate. Histidine 75-78 laccase 2 Bombyx mori 105-113 33555507-8 2021 The results from Hi-MethylSeq showed that the hypermethylation of SGK1 in both blood and decidua samples in RPL patients, which was consistent to its lower expression in endometrium reported earlier. Histidine 17-19 serum/glucocorticoid regulated kinase 1 Homo sapiens 66-70 33903307-10 2021 Mutation analysis which was done 70 months after commencement of nilotinib showed the presence of BCRABL1 kinase domain mutation with nucleotide substitution at position 1187 from Histidine(H) to Proline(P) (H396P). Histidine 180-189 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 98-105 8547274-2 1996 First, a mutant of annexin V was constructed with an N-terminal extension of six amino acids (Met-Ala-Cys-Asp-His-Ser) and with Cys316 mutated to Ser; this molecule was expressed in Escherichia coli. Histidine 110-113 annexin A5 Rattus norvegicus 19-28 8573077-8 1996 Our results are consistent with Zn2+ chelation by the highly conserved histidine residues homologous to the histidines at the classical copper-binding sites in tyrosinase. Histidine 71-80 tyrosinase Homo sapiens 160-170 32656613-10 2020 Recombinant HO1 (rHO1) was successfully induced by 0.1 mmol/l IPTG and purified by Ni-NTA His Bind Resin purification system. Histidine 90-93 heme oxygenase 1 Rattus norvegicus 12-15 32656613-10 2020 Recombinant HO1 (rHO1) was successfully induced by 0.1 mmol/l IPTG and purified by Ni-NTA His Bind Resin purification system. Histidine 90-93 heme oxygenase 1 Rattus norvegicus 17-21 32592084-2 2020 Histidine recognition was effected by histidyl-tRNA synthetase (HisRS), and its detection was signaled colorimetrically based on the molybdenum blue reaction. Histidine 0-9 histidyl-tRNA synthetase 1 Homo sapiens 38-62 32592084-2 2020 Histidine recognition was effected by histidyl-tRNA synthetase (HisRS), and its detection was signaled colorimetrically based on the molybdenum blue reaction. Histidine 0-9 histidyl-tRNA synthetase 1 Homo sapiens 64-69 8573077-8 1996 Our results are consistent with Zn2+ chelation by the highly conserved histidine residues homologous to the histidines at the classical copper-binding sites in tyrosinase. Histidine 108-118 tyrosinase Homo sapiens 160-170 8631326-6 1996 Protein mass fingerprinting with tryptic fragments identified p57 as a protein related to protein disulfide-isomerase which belongs to the superfamily of Cys-Gly-His-Cys-containing sequences. Histidine 162-165 prolyl 4-hydroxylase subunit beta Rattus norvegicus 90-117 8532526-1 1995 The human DNA repair protein XRCC1 was overexpressed as a histidine-tagged polypeptide (denoted XRCC1-His) in Escherichia coli and purified in milligram quantities by affinity chromatography. Histidine 58-67 X-ray repair cross complementing 1 Homo sapiens 29-34 8532526-1 1995 The human DNA repair protein XRCC1 was overexpressed as a histidine-tagged polypeptide (denoted XRCC1-His) in Escherichia coli and purified in milligram quantities by affinity chromatography. Histidine 58-67 X-ray repair cross complementing 1 Homo sapiens 96-101 8532526-1 1995 The human DNA repair protein XRCC1 was overexpressed as a histidine-tagged polypeptide (denoted XRCC1-His) in Escherichia coli and purified in milligram quantities by affinity chromatography. Histidine 102-105 X-ray repair cross complementing 1 Homo sapiens 29-34 8532526-1 1995 The human DNA repair protein XRCC1 was overexpressed as a histidine-tagged polypeptide (denoted XRCC1-His) in Escherichia coli and purified in milligram quantities by affinity chromatography. Histidine 102-105 X-ray repair cross complementing 1 Homo sapiens 96-101 8530633-2 1995 Affected individuals have a single base substitution in exon 8 of CYP11B1 gene, codon 448, from CGC (arginine) to CAC (histidine) (R448H), a mutation that abolishes enzyme activity completely. Histidine 119-128 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 66-73 32199697-5 2020 RESULTS: The liver expression levels of APOA1bp were associated with lower cIMT and leukocyte counts, a better plasma lipid profile and higher circulating levels of metabolites associated with lower risk of atherosclerosis (glycine, histidine and asparagine). Histidine 233-242 NAD(P)HX epimerase Homo sapiens 40-47 32888909-8 2020 Noteworthy, most modifications were observed at Lys and His residues located at A-site (K73, K87, K88), L-site (H26, H33, and K27) membrane binding sites. Histidine 56-59 keratin 73 Homo sapiens 88-91 32879443-6 2020 Moreover, the mutation of histidine 200 of JMJD8 (JMJD8-H200Q) disrupted its binding with AKT1 and increased interaction of SETDB1 and PDK1 with AKT1. Histidine 26-35 pyruvate dehydrogenase kinase 1 Homo sapiens 135-139 32982370-5 2020 The catalytic mechanism of sPLA2 is initiated by a histidine/aspartic acid/calcium complex within the active site. Histidine 51-60 phospholipase A2 group IIA Homo sapiens 27-32 32973811-4 2020 We found that multiple immunizations of HIS-CD8/NKT mice with the nanovaccine resulted in the activation and/or expansion of human CD141+ DCs and iNKT cells and ultimately elicited a potent Melan-A-specific CD8+ T cell response, as determined by tetramer staining and ELISpot assay. Histidine 40-43 CD8a molecule Homo sapiens 44-47 7489704-3 1995 The amino-terminal domain binds in a substrate-like manner to the narrow active-site cleft of thrombin; the imidazole group of the P1 His residue extends into the S1 pocket to form favourable hydrogen/ionic bonds with Asp189 at its bottom, and additionally with Glu192 at its entrance. Histidine 134-137 coagulation factor II, thrombin Bos taurus 94-102 7479069-9 1995 Mutations at three sites, histidine 126, aspartic acid 128 and aspartic acid 130, that are conserved in a subfamily of the plasmid mobilization proteins, led to the loss of VirD2 activity. Histidine 26-35 type IV secretion system T-DNA border endonuclease VirD2 Agrobacterium tumefaciens 173-178 7577912-1 1995 The active site of pig heart citrate synthase contains a histidine residue (H320) which interacts with the carbonyl oxygen of oxaloacetate and is implicated in substrate activation through carbonyl bond polarization, a major catalytic strategy of the enzyme. Histidine 57-66 citrate synthase Sus scrofa 29-45 7561101-7 1995 Sequence analysis of wild-type CEM and CEM-NKR CD44 cDNA demonstrated a G to A point mutation at position 575 in the CD44 cDNA of CEM-NKR, resulting in an arginine to histidine mutation at aa position 154. Histidine 167-176 CD44 molecule (Indian blood group) Homo sapiens 47-51 7561101-7 1995 Sequence analysis of wild-type CEM and CEM-NKR CD44 cDNA demonstrated a G to A point mutation at position 575 in the CD44 cDNA of CEM-NKR, resulting in an arginine to histidine mutation at aa position 154. Histidine 167-176 CD44 molecule (Indian blood group) Homo sapiens 117-121 7592604-2 1995 Chemical modification data implicate histidine as a catalytic residue of PBGS from both plants and mammals. Histidine 37-46 aminolevulinate dehydratase Homo sapiens 73-77 7592604-4 1995 Only one histidine is species-invariant among 17 known sequences of PBGS which have high overall sequence similarity. Histidine 9-18 aminolevulinate dehydratase Homo sapiens 68-72 7592604-5 1995 In Escherichia coli PBGS, this histidine is His128. Histidine 31-40 aminolevulinate dehydratase Homo sapiens 20-24 7592604-15 1995 We observe a pKa of approximately 7.5 in the wild type PBGS kcat/Km pH profile as well as in those of H128A and H126/128A, suggesting that this pKa is not the result of protonation/deprotonation of one of these histidines. Histidine 211-221 aminolevulinate dehydratase Homo sapiens 55-59 7592604-17 1995 This is consistent with a role for one or both of these histidines as a ligand to the required Zn(II) of E. coli PBGS, which is known to participate in substrate binding. Histidine 56-66 aminolevulinate dehydratase Homo sapiens 113-117 8561858-1 1995 Results of the present investigation indicate that mouse gamma-nerve growth factor (gamma-NGF), which belongs to the kallikrein family of proteins, specifically cleaves the Phe-His bond of a synthetic renin substrate and exhibits rat-tonin-like activity. Histidine 177-180 kallikrein 1-related peptidase b3 Mus musculus 57-82 8561858-1 1995 Results of the present investigation indicate that mouse gamma-nerve growth factor (gamma-NGF), which belongs to the kallikrein family of proteins, specifically cleaves the Phe-His bond of a synthetic renin substrate and exhibits rat-tonin-like activity. Histidine 177-180 kallikrein 1-related peptidase b3 Mus musculus 84-93 7548163-2 1995 The PI-6 cDNA was modified to encode six histidine residues immediately after the initiation codon, and was placed under the control of the P. pastoris alcohol oxidase promoter in the vector pHIL-D2. Histidine 41-50 serpin family B member 6 Homo sapiens 4-8 7677750-4 1995 Substitution of His-117 with polar, charged, or hydrophobic amino acid resulted in complete abolishment of the tyrosinase activity but no effect on its secretion. Histidine 16-19 tyrosinase Homo sapiens 111-121 7677750-5 1995 When similar amino acid substitutions were introduced at His-102, both the secretion and the enzymatic activity of tyrosinase were blocked to different extents. Histidine 57-60 tyrosinase Homo sapiens 115-125 7677750-6 1995 Furthermore, the tyrosinase activity of the His-117 mutants but not the His-102 mutants could be partially reactivated by in vitro copper reconstitution. Histidine 44-47 tyrosinase Homo sapiens 17-27 8530107-1 1995 Histidase (EC 4.3.1.3) is a cytosolic enzyme that catalyzes the nonoxidative deamination of histidine to urocanic acid. Histidine 92-101 histidine ammonia-lyase Homo sapiens 0-9 32823853-8 2020 Postprandial AA histidine (p < 0.001), leucine (p < 0.001), and tyrosine (p < 0.001) were higher in CGMP-AA2 than CGMP-AA1, and leucine (p < 0.001), threonine (p < 0.001), and tyrosine (p = 0.003) higher in GCMP-AA2 than Phe-free AA. Histidine 16-25 AA2 Homo sapiens 105-108 32664726-0 2020 Detection of OG:A lesion mispairs by MutY relies on a single His residue and the 2-amino group of 8-oxoguanine. Histidine 61-64 mutY DNA glycosylase Homo sapiens 37-41 32664726-3 2020 Herein we use a combination of in vitro and bacterial cell repair assays with single molecule fluorescence microscopy to demonstrate that both a C-terminal domain histidine residue and the 2-amino group of OG base are critical for MutY detection of OG:A sites. Histidine 163-172 mutY DNA glycosylase Homo sapiens 231-235 7654686-2 1995 This approach facilitated the rapid purification of native-like, histidine-cleaved GroES (HC-GroES). Histidine 65-74 chaperonin GroES Escherichia coli 83-88 7656990-2 1995 Among them, NTR1 codes for a membrane protein with weak histidine transport activity. Histidine 56-65 peptide transporter 2 Arabidopsis thaliana 12-16 7643379-1 1995 The two zinc fingers of the yeast transcription factor Adr1p recognize the 6 bp sequence TTG GAG site in which the first finger, a His-X3-His finger, recognizes the G-rich triplet (GAG) and the second zinc finger, a His-X4-His finger, recognizes the T-rich sequence (TTG). Histidine 131-134 DNA-binding transcription factor ADR1 Saccharomyces cerevisiae S288C 55-60 32637952-4 2020 As a cysteine protease, PLpro is rich in cysteines and histidines and their protonation/deprotonation modulates catalysis and conformational plasticity. Histidine 55-65 cathepsin B Homo sapiens 5-22 32359429-4 2020 Analysis of the naked mole-rat genome revealed, uniquely among mammals, a histidine point variation in the neuronal potassium-chloride cotransporter 2 (KCC2). Histidine 74-83 solute carrier family 12 member 5 Homo sapiens 152-156 32359429-5 2020 A histidine missense substitution mutation at this locus in the human ortholog of KCC2, found previously in patients with febrile seizures and epilepsy, has been demonstrated to diminish neuronal Cl- extrusion capacity, and thus impairs GABAergic inhibition. Histidine 2-11 solute carrier family 12 member 5 Homo sapiens 82-86 32492011-7 2020 Nevertheless, Ngb contains both proximal and distal conserved heme-biding histidines. Histidine 74-84 neuroglobin Homo sapiens 14-17 7643379-1 1995 The two zinc fingers of the yeast transcription factor Adr1p recognize the 6 bp sequence TTG GAG site in which the first finger, a His-X3-His finger, recognizes the G-rich triplet (GAG) and the second zinc finger, a His-X4-His finger, recognizes the T-rich sequence (TTG). Histidine 138-141 DNA-binding transcription factor ADR1 Saccharomyces cerevisiae S288C 55-60 7643379-1 1995 The two zinc fingers of the yeast transcription factor Adr1p recognize the 6 bp sequence TTG GAG site in which the first finger, a His-X3-His finger, recognizes the G-rich triplet (GAG) and the second zinc finger, a His-X4-His finger, recognizes the T-rich sequence (TTG). Histidine 138-141 DNA-binding transcription factor ADR1 Saccharomyces cerevisiae S288C 55-60 7643379-1 1995 The two zinc fingers of the yeast transcription factor Adr1p recognize the 6 bp sequence TTG GAG site in which the first finger, a His-X3-His finger, recognizes the G-rich triplet (GAG) and the second zinc finger, a His-X4-His finger, recognizes the T-rich sequence (TTG). Histidine 138-141 DNA-binding transcription factor ADR1 Saccharomyces cerevisiae S288C 55-60 7623840-2 1995 Previous studies have shown that in response to histidine starvation, GCN2 phosphorylates eukaryotic initiation factor 2 (eIF-2), to induce the translational expression of GCN4, a transcriptional activator of genes subject to the general amino acid control. Histidine 48-57 eukaryotic translation initiation factor 2 alpha kinase 4 Homo sapiens 70-74 7623840-6 1995 We show that GCN2 phosphorylation of eIF-2, and the resulting general amino acid control pathway, is stimulated in response to starvation for each of several different amino acids, in addition to histidine limitation. Histidine 196-205 eukaryotic translation initiation factor 2 alpha kinase 4 Homo sapiens 13-17 7544128-2 1995 An anti-peptide antibody targeted to the C-terminus of CYP7 was produced by immunising rabbits with the synthetic peptide Tyr-Lys-Leu-Lys-His. Histidine 138-141 cytochrome P450 7A1 Oryctolagus cuniculus 55-59 7628475-2 1995 Thus, of the three His residues contained in adrenodoxin, His56 is closest to Tyr82, and hence to the highly acidic determinant region of adrenodoxin that is the interaction site for adrenodoxin reductase and P-450. Histidine 19-22 ferredoxin reductase Bos taurus 183-204 7607641-4 1995 DNA sequence analysis of polymerase chain reaction (PCR)-amplified DNA of all six LCAT exons revealed a new point mutation in exon IV of the LCAT gene, i.e., a G to A substitution in codon 140 converting Arg to His. Histidine 211-214 lecithin-cholesterol acyltransferase Homo sapiens 82-86 7607641-4 1995 DNA sequence analysis of polymerase chain reaction (PCR)-amplified DNA of all six LCAT exons revealed a new point mutation in exon IV of the LCAT gene, i.e., a G to A substitution in codon 140 converting Arg to His. Histidine 211-214 lecithin-cholesterol acyltransferase Homo sapiens 141-145 7754945-4 1995 Histidine at position 30 of the HLA-DQB1 gene was associated with disease (62% of patients compared to 36% of controls), whereas homozygosity for leucine at position 26 was more frequent in controls (36% vs 18% of patients). Histidine 0-9 major histocompatibility complex, class II, DQ beta 1 Homo sapiens 32-40 7637580-0 1995 Molecular cloning of cDNA encoding a bovine selenoprotein P-like protein containing 12 selenocysteines and a (His-Pro) rich domain insertion, and its regional expression. Histidine 110-113 selenoprotein P Bos taurus 44-72 32496146-10 2020 The hydrogen-bonding interaction of T3 with TRalpha at His-381 was also shared by majority of analogs. Histidine 55-58 T cell receptor alpha locus Homo sapiens 44-51 32483417-12 2020 Using a nude mouse xenograft model, we verified that inhibiting JMJD2B could decrease the levels of amino acids (Asn, Phe, His). Histidine 123-126 lysine (K)-specific demethylase 4B Mus musculus 64-70 32210794-7 2020 The molecular docking and further experiments demonstrated that HgCl2 bound to the amino residuals (His) in the catalytic center of tyrosinase. Histidine 100-103 tyrosinase Homo sapiens 132-142 32880207-12 2020 Arg39 is also predicted to alter the pK A of a key catalytic histidine residue at position 160, further attenuating ARG2"s enzymatic function. Histidine 61-70 arginase 2 Homo sapiens 116-120 31493373-5 2019 In this work, we characterized a highly conserved histidine (H208), present at TM5-ICL3 region of T2R14 and its role in agonist-induced T2R14 signaling. Histidine 50-59 tropomyosin 3 Homo sapiens 79-82 31145609-10 2019 Further electron-nuclear double resonance studies with globally 15N-labeled mCP provided hyperfine couplings from the coordinating epsilon-nitrogen atoms of the His ligands (aiso = 4.3 MHz) as well as the distal delta-nitrogen atoms (aiso = 0.25 MHz). Histidine 161-164 CD46 antigen, complement regulatory protein Mus musculus 76-79 31569521-2 2019 Its lipid inhibition effects indicated that the synthetic peptide PP1 exhibits a good inhibitory effect against porcine pancreatic lipase (PL) (47.95%) at 200 mug/mL, which could be attributed to its hydrogen binding into catalytic sites of PL (Ser153, Asp177, and His 264) by docking analysis. Histidine 265-268 pancreatic lipase Mus musculus 120-137 7757970-2 1995 We produced a recombinant MAGE-3 gene product by expression cloning of the entire reading frame in the context of a fusion protein characterized by a 10-histidine tail, allowing purification by metal chelation on a nickel Sepharose column. Histidine 153-162 MAGE family member A3 Homo sapiens 26-32 7590793-2 1995 The anti-TRH antibodies were raised by immunization with a TRH-bovine serum albumin conjugate obtained by coupling of the CO2H group of pGlu-His-Pro-OH to NH2 groups in the protein. Histidine 141-144 thyrotropin releasing hormone Mus musculus 9-12 7590793-2 1995 The anti-TRH antibodies were raised by immunization with a TRH-bovine serum albumin conjugate obtained by coupling of the CO2H group of pGlu-His-Pro-OH to NH2 groups in the protein. Histidine 141-144 thyrotropin releasing hormone Mus musculus 59-62 7590793-5 1995 Characterization of the anti-TRH antibodies showed that in general they are specific for the pGlu-His moiety. Histidine 98-101 thyrotropin releasing hormone Mus musculus 29-32 7590793-7 1995 The specificities of these antibodies are markedly different from those previously obtained using TRH coupled through the histidine residue to protein as the immunogen. Histidine 122-131 thyrotropin releasing hormone Mus musculus 98-101 7782943-4 1995 We have developed an efficient histidine-tagged bacterial expression system that allows the folding and assembly of E1 alpha and E1 beta subunits into the E1 heterotetramer (alpha 2 beta 2) in the presence of overexpressed chaperonins GroEL and GroES. Histidine 31-40 heat shock protein family D (Hsp60) member 1 Homo sapiens 235-240 7759520-8 1995 The ESR spectrum of high-spin cytochrome b558 was identical to that of methemoglobin, suggesting that the axial-ligand type in both hemoproteins may be the same, i.e. histidine is the fifth ligand. Histidine 167-176 cytochrome b Sus scrofa 30-42 7761440-4 1995 In contrast, the three-dimensional structure of threonine-199-->histidine (T199H) CAII, determined to 2.25-Angstrum resolution, indicates that the engineered imidazole side chain rotates away from the metal and does not coordinate to zinc; this results in a weaker zinc-binding site. Histidine 67-76 carbonic anhydrase 2 Homo sapiens 85-89 7755634-1 1995 The human histidyl-tRNA synthetase (HRS) gene encodes an enzyme that catalyzes the esterification of histidine to its cognate tRNA as an early step in protein biosynthesis. Histidine 101-110 histidyl-tRNA synthetase 1 Homo sapiens 10-34 7755634-1 1995 The human histidyl-tRNA synthetase (HRS) gene encodes an enzyme that catalyzes the esterification of histidine to its cognate tRNA as an early step in protein biosynthesis. Histidine 101-110 histidyl-tRNA synthetase 1 Homo sapiens 36-39 7737993-5 1995 In a recent study, we have shown that GroEL interacts preferentially with the side chains of hydrophobic amino acids (Ile, Phe, Val, Leu, and Trp) and more weakly with several polar or charged amino acids, including the strongest alpha-helix and beta-sheet formers (Glu, Gln, His, Thr, and Tyr). Histidine 276-279 heat shock protein family D (Hsp60) member 1 Homo sapiens 38-43 7588568-6 1995 Recombinant uPAR from E. coli (corresponding to amino acids 1-284 of human uPAR) was expressed with an N-terminal histidine-tag insertion and purified by nickel chelate affinity chromatography. Histidine 114-123 urokinase plasminogen activator surface receptor Cricetulus griseus 12-16 7733674-8 1995 This prokaryotic expression system yields moderate amounts of unmodified recombinant His-cPLA2 and is advantageous for rapid production of protein and mutational analyses. Histidine 85-88 phospholipase A2 group IVA Homo sapiens 89-94 7713895-0 1995 Molecular and biochemical evidence for the involvement of the Asp-333-His-523 pair in the catalytic mechanism of soluble epoxide hydrolase. Histidine 70-73 epoxide hydrolase 2, cytoplasmic Mus musculus 113-138 7723029-2 1995 Com contains six cysteine and five histidine residues that have the potential to form several alternative zinc-finger-like motifs. Histidine 35-44 Com family DNA-binding transcriptional regulator Escherichia phage Mu 0-3 31284551-4 2019 In this work, we have synthesized new histidine-rich lysine-based dendrimers (Lys-2His dendrimer) with two linear histidine (His) residues in every inner segment. Histidine 38-47 aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Homo sapiens 78-83 31284551-4 2019 In this work, we have synthesized new histidine-rich lysine-based dendrimers (Lys-2His dendrimer) with two linear histidine (His) residues in every inner segment. Histidine 114-123 aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Homo sapiens 78-83 31152065-4 2019 Ddi2 enzymatically hydrates cyanamide to urea and belongs to the family of HD-domain metalloenzymes (named after conserved active-site metal-binding His and Asp residues). Histidine 149-152 cyanamide hydratase Saccharomyces cerevisiae S288C 0-4 31209258-5 2019 Here, we developed pro-TGFbeta2 production systems based on human Expi293F cells, which yielded >2 mg of pure histidine- or Strep-tagged protein per liter of cell culture. Histidine 110-119 transforming growth factor beta 2 Homo sapiens 23-31 31197133-2 2019 Here, we report designed ankyrin repeat proteins (DARPins) macromolecules that specifically inhibit the KRAS isoform by binding to an allosteric site encompassing the region around KRAS-specific residue histidine 95 at the helix alpha3/loop 7/helix alpha4 interface. Histidine 203-212 KRAS proto-oncogene, GTPase Homo sapiens 104-108 31197133-2 2019 Here, we report designed ankyrin repeat proteins (DARPins) macromolecules that specifically inhibit the KRAS isoform by binding to an allosteric site encompassing the region around KRAS-specific residue histidine 95 at the helix alpha3/loop 7/helix alpha4 interface. Histidine 203-212 KRAS proto-oncogene, GTPase Homo sapiens 181-185 32477731-0 2019 Direct His-bundle Pacing in a Patient with a Persistent Left Superior Vena Cava. Histidine 7-10 carbonic anhydrase 5A Homo sapiens 75-79 30826412-6 2019 The results showed that the GST-VP28, His-tagged Rab7 (His-Rab7) and His-beta-actin formed a tripartite complex. Histidine 55-58 POTE ankyrin domain family member F Homo sapiens 73-83 30793391-2 2019 hZIP4 plasma membrane levels are regulated through post-translational modification of its large, disordered, histidine-rich cytosolic loop (ICL2) in response to intracellular zinc concentrations. Histidine 109-118 solute carrier family 39 member 4 Homo sapiens 0-5 31035643-9 2019 However, the amino acid substitution of histidine H38, which is not involved in PLA2 function, to alanine, also affects protease activity, suggesting that the active site/mechanism of the PLA2 and protease function are not identical. Histidine 40-49 phospholipase A2 group IIA Homo sapiens 188-192 30984480-10 2019 Indeed, truncated His-tagged HTU-LOX lacking the N-terminal hydrophobic signal peptide purified under denaturing conditions can be successfully refolded into an active enzyme, and a larger N-terminal truncation further increases the amine oxidase activity. Histidine 18-21 lysyl oxidase Homo sapiens 33-36 30944256-5 2019 Administration of histidine-tagged sPRR, sPRR-His, stimulated V2R expression and also reversed the inhibitory effect of PF-429242 on the expression induced by AVP. Histidine 18-27 arginine vasopressin receptor 2 Mus musculus 62-65 30944256-5 2019 Administration of histidine-tagged sPRR, sPRR-His, stimulated V2R expression and also reversed the inhibitory effect of PF-429242 on the expression induced by AVP. Histidine 46-49 arginine vasopressin receptor 2 Mus musculus 62-65 7781967-2 1995 The primary structure of VIP from both species was the same: His-Ser-Asp-Ala-Ile-Phe-Thr-Asp-Asn-Tyr10- Ser-Arg-Phe-Arg-Lys-Gln-Met-Ala-Val-Lys20-Lys-Tyr-Leu-Asn-Ser-Val- Leu-Thr. Histidine 61-64 vasoactive intestinal peptide Gallus gallus 25-28 30988643-9 2019 The effect of a PP13 variant with a histidine-tag (His-PP13) remained the same between 7 and 13 days. Histidine 36-45 galectin 13 Homo sapiens 16-20 30988643-9 2019 The effect of a PP13 variant with a histidine-tag (His-PP13) remained the same between 7 and 13 days. Histidine 36-45 galectin 13 Homo sapiens 55-59 30988643-9 2019 The effect of a PP13 variant with a histidine-tag (His-PP13) remained the same between 7 and 13 days. Histidine 51-54 galectin 13 Homo sapiens 16-20 30988643-9 2019 The effect of a PP13 variant with a histidine-tag (His-PP13) remained the same between 7 and 13 days. Histidine 51-54 galectin 13 Homo sapiens 55-59 30886237-2 2019 To explore the role of histidine protonation in the binding process, the pH-dependence of bile salt binding and internal dynamics in hI-BABP was investigated using NMR spectroscopy and biophysical tools. Histidine 23-32 fatty acid binding protein 6 Homo sapiens 133-140 32216237-5 2019 Yeast two-hybrid assay showed the growth of SPAG6 and SPINK2 in the selective culture medium SD/-Leu/-Trp/-His, and the transfection of the CHO cells revealed the co-localization of SPAG6 and SPINK2 around the nuclei. Histidine 107-110 sperm-associated antigen 6 Cricetulus griseus 44-49 30600941-6 2019 On the other hand, the system of [Eu(pda)2 ]- with histidine favors hetero-allosteric association over homo-association. Histidine 51-60 transcription factor AP-2 beta Homo sapiens 37-42 30463969-4 2019 We previously characterized the role of two highly conserved histidine residues, H348 and H352, located in an external, juxtamembrane region of the E2 protein termed the D-loop. Histidine 61-70 ubiquitin conjugating enzyme E2 B Homo sapiens 148-158 30554660-5 2019 GST-SSL5 was found to attenuate the inhibitory activity of recombinant histidine-tagged C1Inh (C1Inh-His) toward complement C1s. Histidine 71-80 serpin family G member 1 Homo sapiens 88-93 30554660-5 2019 GST-SSL5 was found to attenuate the inhibitory activity of recombinant histidine-tagged C1Inh (C1Inh-His) toward complement C1s. Histidine 71-80 serpin family G member 1 Homo sapiens 95-104 30697165-4 2018 Both necroptosis inhibitors of RIPK1 and RIPK3 and a necroptosis activator/apoptosis inhibitor z-VAD increased cell death caused by L-histidine, but not L-arginine or L-ornithine. Histidine 132-143 receptor-interacting serine-threonine kinase 3 Mus musculus 41-46 30012884-5 2018 Substitution of this histidine, and the consequent decreases in GAPDH heme binding, antagonized heme delivery to both cytosolic and nuclear hemeprotein targets, including inducible nitric-oxide synthase (iNOS) in murine macrophages and the nuclear transcription factor Hap1 in yeast, even though this GAPDH variant caused cellular levels of labile heme to rise dramatically. Histidine 21-30 glyceraldehyde-3-phosphate dehydrogenase Mus musculus 64-69 30173739-4 2018 Next, the amino acids including His-159 in nsp1beta, and His-129, His-144 and Lys-173 in nsp11 were determined to play crucial roles in the reduction of CH25H. Histidine 32-35 cholesterol 25-hydroxylase Homo sapiens 153-158 30173739-4 2018 Next, the amino acids including His-159 in nsp1beta, and His-129, His-144 and Lys-173 in nsp11 were determined to play crucial roles in the reduction of CH25H. Histidine 57-60 cholesterol 25-hydroxylase Homo sapiens 153-158 30173739-4 2018 Next, the amino acids including His-159 in nsp1beta, and His-129, His-144 and Lys-173 in nsp11 were determined to play crucial roles in the reduction of CH25H. Histidine 57-60 cholesterol 25-hydroxylase Homo sapiens 153-158 29936834-0 2018 Identification of the Histidine Residue in Vitamin D Receptor That Covalently Binds to Electrophilic Ligands. Histidine 22-31 vitamin D receptor Homo sapiens 43-61 7753050-4 1995 Although feline CD9 appears most homologous to human CD9, it has two important features in common with bovine and murine CD9: the presence of a histidine residue at position 192 which is absent from the corresponding position (194) in human CD9; and the absence of two asparagine residues which are found at positions 51 and 52 of human CD9. Histidine 144-153 CD9 molecule Homo sapiens 16-19 30029625-8 2018 RESULTS: A novel mutation in the FOXL2 gene (c.931C > T) was detected in all five BPES patients, which converts a histidine residue into a tyrosine (p.H311Y) in the FOXL2 protein. Histidine 117-126 forkhead box L2 Homo sapiens 33-38 30029625-8 2018 RESULTS: A novel mutation in the FOXL2 gene (c.931C > T) was detected in all five BPES patients, which converts a histidine residue into a tyrosine (p.H311Y) in the FOXL2 protein. Histidine 117-126 forkhead box L2 Homo sapiens 168-173 29872214-1 2018 Zinc modulates the biological function of histidine-rich glycoprotein (HRG) through binding to its His-rich region (HRR). Histidine 99-102 histidine rich glycoprotein Homo sapiens 71-74 29696512-7 2018 Expression of PI3K-Akt-mTOR/JNK (24 h after HI or OGD/R) proteins was detected by Western blotting after stimulation with HI, NGR1, LY294002 (PI3K inhibitor), 740Y-P (PI3K agonist), or ICI 182780(estrogen receptors inhibitor). Histidine 44-46 mechanistic target of rapamycin kinase Rattus norvegicus 23-27 29366964-5 2018 cDNA fragments of human DLL1, encoding truncated versions of DLL1 with regions required to activate Notch receptors, were cloned and expressed as histidine-fused proteins in bacterial and mammalian cells. Histidine 146-155 delta like canonical Notch ligand 1 Homo sapiens 24-28 7706275-0 1995 Exposure of hydrophobic surfaces on the chaperonin GroEL oligomer by protonation or modification of His-401. Histidine 100-103 heat shock protein family D (Hsp60) member 1 Homo sapiens 51-56 7706275-1 1995 Hydrophobic exposure on the chaperonin GroEL is increased 6-10-fold after the protein is treated with the His-reactive reagent diethyl pyrocarbonate (DEP), or the solution pH is lowered to 5.5. Histidine 106-109 heat shock protein family D (Hsp60) member 1 Homo sapiens 39-44 7706275-3 1995 The pKa for the pH-induced transition is 6.6, most likely attributable to the only histidine in GroEL, His-401, located in the intermediate domain. Histidine 83-92 heat shock protein family D (Hsp60) member 1 Homo sapiens 96-101 7706275-3 1995 The pKa for the pH-induced transition is 6.6, most likely attributable to the only histidine in GroEL, His-401, located in the intermediate domain. Histidine 103-106 heat shock protein family D (Hsp60) member 1 Homo sapiens 96-101 7896796-7 1995 The amino-terminal incompatibility site was identified as position 5 (Ile in PTH and His in PTHrP), because Ile5-hybrid-1 bound with high affinity (IC50 approximately equal to 20 nM). Histidine 85-88 parathyroid hormone-like hormone Rattus norvegicus 92-97 7880816-7 1995 ADR1 mutants with either His or Lys in the central +3 residue (146) of zinc finger two, which have Arg149 in the +6 alpha-helical position, bind with UAS1 mutant sequences having G5 very strongly, T5 strongly, A5 intermediately, and C5 weakly. Histidine 25-28 DNA-binding transcription factor ADR1 Saccharomyces cerevisiae S288C 0-4 7893699-7 1995 EPR and EXAFS studies of oxidized PHM indicate that the active site contains type 2 copper in a tetragonal environment; the copper is coordinated to two to three His and one to two additional O/N ligands, probably solvent, again supporting the structural homology of PHM and D beta M. Mutation of the Met residues common to PHM and D beta M to Ile identified Met314 as critical for catalytic activity. Histidine 162-165 peptidylglycine alpha-amidating monooxygenase Homo sapiens 34-37 7705335-4 1995 FIP-fve consists of 114 amino acid residues with an acetylated amino end, and lacks methionine, half-cystine and histidine residues. Histidine 113-122 upstream transcription factor 2, c-fos interacting Homo sapiens 0-3 7853501-3 1995 Using affinity-purified histidine-tagged NS1 preparations, we have shown that the specific protein-DNA interaction is of moderate affinity, being stable in 0.1 M salt but rapidly lost at higher salt concentrations. Histidine 24-33 influenza virus NS1A binding protein Homo sapiens 41-44 29489419-3 2018 This insert mutation introduces five additional amino acid residues YAVHY after histidine at the 95 site (p.H95_A96insYAVHY) within the second transmembrane (TM2) domain of Cx50 protein (Cx50-insert). Histidine 80-89 gap junction protein alpha 8 Homo sapiens 173-177 29330883-5 2018 A high percentage of RERE pathogenic variants affect a histidine-rich region in the Atrophin-1 domain. Histidine 55-64 arginine-glutamic acid dipeptide repeats Homo sapiens 21-25 29561549-5 2018 While palladium acetate was able to generate oscillations under the conditions already established in our previous research on PdI2-catalysed oscillators, the other two catalysts needed the addition of HI to induce oscillations. Histidine 202-204 peptidyl arginine deiminase 2 Homo sapiens 127-131 29566507-2 2018 Recently, a potential treatment for CO poisoning was introduced, based on binding of CO by neuroglobin (Ngb) with a mutated distal histidine (H64Q). Histidine 131-140 neuroglobin Homo sapiens 91-102 29566507-2 2018 Recently, a potential treatment for CO poisoning was introduced, based on binding of CO by neuroglobin (Ngb) with a mutated distal histidine (H64Q). Histidine 131-140 neuroglobin Homo sapiens 104-107 29220567-7 2018 Although KDM6A and KDM6B differ in primary sequence, particularly in the H3L20 binding pocket of the zinc binding domains, where two histidines in KDM6A have been replaced by a glutamate and a tyrosine, they bind H3(17-23) in a very similar fashion. Histidine 133-143 lysine demethylase 6B Homo sapiens 19-24 28460164-5 2018 As expected, our hybrid molecule 10 [SNIPER(CH6)] efficiently degraded His-tagged CRABP-II and Smad2 in cells. Histidine 71-74 cellular retinoic acid binding protein 2 Homo sapiens 82-90 7873529-7 1995 Conversely, modification of arginine or histidine residues of HPRG has no effect on complex formation. Histidine 40-49 histidine rich glycoprotein Homo sapiens 62-66 7875301-2 1995 TIMP-2, an inhibitory protein of 72 kDa gelatinase/type IV collagenase (MMP-2), was expressed in Escherichia coli as a fusion protein with a 34 amino acid NH2-linked tail containing six consecutive histidine residues. Histidine 198-207 TIMP metallopeptidase inhibitor 2 Homo sapiens 0-6 7849014-0 1995 Site-directed mutagenesis of conserved histidines in the helix VIII domain of PsaB impairs assembly of the photosystem I reaction center without altering spectroscopic characteristics of P700. Histidine 39-49 photosystem I P700 chlorophyll a apoprotein A2 Chlamydomonas reinhardtii 78-82 7849014-2 1995 Histidine residues in the most highly conserved region of the PsaB protein are predicted to coordinate the P700 reaction center chlorophyll(s) and the initial electron acceptor, A0. Histidine 0-9 photosystem I P700 chlorophyll a apoprotein A2 Chlamydomonas reinhardtii 62-66 7847389-4 1995 A genomic polymorphism of LMP7 was found strongly associated with IDDM, and the Arg/His-60 polymorphism in LMP2 was found associated with IDDM only in subjects containing an HLA DR4-DQB1*0302 haplotype. Histidine 84-87 major histocompatibility complex, class II, DR beta 4 Homo sapiens 178-181 7630888-4 1995 This fusion toxin has a deduced molecular weight of 67 440 and is formed by the fusion of the first 389 amino acids of diphtheria toxin to amino acids 15-200 of mature human CNTF (Cys17-->Ser), using a bridge of 34 additional amino acids including six consecutive histidine residues. Histidine 267-276 ciliary neurotrophic factor Homo sapiens 174-178 7851422-5 1995 Proline residues of helix 6, that are conserved in all human glucose-transporter isoforms except for the human GLUT2, were mutated either to alanine or to the corresponding residues of GLUT2, i.e. to histidine (P187H), arginine (P196R) or phenylalanine (P205F). Histidine 200-209 solute carrier family 2 member 2 Homo sapiens 185-190 8175672-1 1994 The metalloendopeptidase EC 3.4.24.15 is believed to degrade gonadotropin-releasing hormone (GnRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2) by cleavage at the Tyr5-Gly6 bond. Histidine 105-108 thimet oligopeptidase 1 Rattus norvegicus 4-24 8187056-2 1994 In DNA from one tumor we found that the histidine codon 193 (CAT) was somatically converted to arginine (CGT). Histidine 40-49 UDP glycosyltransferase 8 Homo sapiens 105-108 8132511-2 1994 Site-directed mutagenesis was used to replace His-163 in the Loop 1 region of the recA protein with a tryptophan residue. Histidine 46-49 RAD51 recombinase Homo sapiens 82-86 29370305-7 2018 Results show that three different mutations affecting histidine at position 12 affected Env incorporation into virions that correlated with reduction of virus infectivity and DC-SIGN-mediated virus capture and transmission. Histidine 54-63 endogenous retrovirus group K member 20 Homo sapiens 88-91 8300595-7 1994 Both mutant phenotypes are dominant over wild-type VirA, and both need the conserved histidine at the autophosphorylation site for strong inducer-independent vir transcription. Histidine 85-94 two-component VirA-like sensor kinase Agrobacterium tumefaciens 51-55 8307012-2 1994 A coagulation factor Xa (FXa)-sensitive cleavage site was introduced to remove the N-terminal histidine tag. Histidine 94-103 coagulation factor X Homo sapiens 14-23 29278328-3 2018 Here we map the spin density distribution onto the cysteine ligands for the three major classes of the protein-bound, reduced [2Fe-2S](His)n(Cys)4-n (n = 0, 1, 2) cluster by selective cysteine-13Cbeta isotope labeling. Histidine 135-138 spindlin 1 Homo sapiens 16-20 8307012-2 1994 A coagulation factor Xa (FXa)-sensitive cleavage site was introduced to remove the N-terminal histidine tag. Histidine 94-103 coagulation factor X Homo sapiens 25-28 8043649-9 1994 In the presence of cAMP, only one histidine participates in the binding process, indicating an asymmetric interaction between the two subunits of the CRP and the DNA. Histidine 34-43 catabolite gene activator protein Escherichia coli 150-153 8264637-4 1994 Affinity chromatography of extract from EM9 cells transfected with pcD2EHX resulted in the copurification of histidine-tagged XRCC1 and DNA ligase III activity. Histidine 109-118 X-ray repair cross complementing 1 Homo sapiens 126-131 8264637-6 1994 The copurification of DNA ligase III activity with histidine-tagged XRCC1 suggests that the two proteins are present in the cell as a complex. Histidine 51-60 X-ray repair cross complementing 1 Homo sapiens 68-73 8253208-0 1993 Characterisation of a novel cysteine/histidine-rich metal binding domain from Xenopus nuclear factor XNF7. Histidine 37-46 Nuclear factor 7 L homeolog Xenopus laevis 101-105 28811265-6 2017 Heterologous expression of Gm gamma-TMT in pET29a expression vector under the control of bacteriophage T7 promoter produced a 37.9 kDa recombinant Gm gamma-TMT protein with histidine hexamer tag at its C-terminus. Histidine 173-182 gamma-tocopherol methyltransferase Glycine max 30-39 28811265-6 2017 Heterologous expression of Gm gamma-TMT in pET29a expression vector under the control of bacteriophage T7 promoter produced a 37.9 kDa recombinant Gm gamma-TMT protein with histidine hexamer tag at its C-terminus. Histidine 173-182 gamma-tocopherol methyltransferase Glycine max 150-159 29032653-3 2017 Bacterial hormone-sensitive lipases (bHSLs), which are homologous to the C-terminal domain of HSL, have alpha/beta-hydrolase fold with a catalytic triad composed of His, Asp, and Ser. Histidine 165-168 lipase E, hormone sensitive type Homo sapiens 38-41 28923481-0 2017 ADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after Histidine 157. Histidine 147-156 ADAM metallopeptidase domain 17 Homo sapiens 0-6 8133211-13 1993 Thrombin resistance resulting from substitution of histidine at position 127 of rbGH did not affect blood GH pharmacokinetic parameters or milk response over other rbGH variants. Histidine 51-60 coagulation factor II, thrombin Bos taurus 0-8 8281191-4 1993 Thus, AAP2 is less selective as compared with AAP1 and transports basic amino acids such as histidine as shown by expression in a histidine transport-deficient yeast strain. Histidine 92-101 amino acid permease 2 Arabidopsis thaliana 6-10 8281191-4 1993 Thus, AAP2 is less selective as compared with AAP1 and transports basic amino acids such as histidine as shown by expression in a histidine transport-deficient yeast strain. Histidine 130-139 amino acid permease 2 Arabidopsis thaliana 6-10 8344434-1 1993 Mouse IgG1, IgG2a, and IgG2b proteins have been selectively labeled with 13C at the carbonyl carbon of His, Met, Trp or Tyr residue and used to prepare the corresponding Fc fragments by limited proteolysis. Histidine 103-106 immunoglobulin heavy constant gamma 2B Mus musculus 23-28 8228729-0 1993 Influence of endogenous cholinergic tone and alpha-adrenergic pathways on growth hormone responses to His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 in the dog. Histidine 102-105 somatotropin Canis lupus familiaris 74-88 7686870-4 1993 The secreted re-NS1 was tagged with six His residues at the C terminus and purified simply by native Ni(2+)-nitrilotriacetic acid (Ni(2+)-NTA) affinity column chromatography. Histidine 40-43 polyglutamine binding protein 1 Homo sapiens 13-19 8463315-5 1993 The role of this site in catalysis was examined by mutating one of the presumptive Zn(2+)-coordinating histidines (His108) in human insulin-degrading enzyme to leucine or glutamine, which were predicted to reduce or eliminate Zn2+ binding without substantially altering secondary structure. Histidine 103-113 insulin degrading enzyme Homo sapiens 132-156 8481357-5 1993 Affected individuals have a single base substitution in exon 8 of CYP11B1, codon 448, from CGC (arginine) to CAC (histidine). Histidine 114-123 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 66-73 28813605-4 2017 Substituting diaminopropionic acid (Dap), DDap, and His at the Asn position yielded potent MC4R ligands, while replacing Ala with Ser maintained MC4R potency. Histidine 52-55 melanocortin 4 receptor Homo sapiens 91-95 28913669-10 2017 These studies identified a copper-binding site involving histidines at positions 2 and 3 that confers a remarkable stabilization of PAI-1 beyond what is observed with vitronectin alone. Histidine 57-67 vitronectin Homo sapiens 167-178 28741928-2 2017 Iterative deconvolution in solution of synthesized modified pentapeptides yielded two potent HtrA3 activators acting in the micromolar range (HCOO-CH2O-C6H4-OCH2-CO-Tyr-Asn-Phe-His-Asn-OH and HCOO-CH2O-C6H4-OCH2-CO-Tyr-Asn-Phe-His-Glu-OH). Histidine 177-180 HtrA serine peptidase 3 Homo sapiens 93-98 28625912-4 2017 The specific activity of the freshly purified hGAPDH constitutes 117 +- 5 mumol NADH/min per mg protein (pH 9.0, 22 C), which is close to the specific activity of rabbit muscle glyceraldehyde-3-phosphate dehydrogenase determined under the same conditions and several times exceeds the specific activity of his-tagged GAPDH preparations. Histidine 307-310 glyceraldehyde-3-phosphate dehydrogenase Oryctolagus cuniculus 47-52 28774948-7 2017 We also found that DrHv1 is comparatively resistant to extracellular Zn2+, which is a potent inhibitor of mammalian Hv1, and this phenomenon appears to reflect variation in the Zn2+-coordinating residue (histidine) within the extracellular linker region in mammalian Hv1. Histidine 204-213 hydrogen voltage-gated channel 1 Danio rerio 19-24 28695845-3 2017 ACHT1 (atypical cysteine/histidine-rich Trx1) is a thylakoid-associated thioredoxin-type protein found in the Arabidopsis thaliana chloroplast. Histidine 25-34 atypical CYS HIS rich thioredoxin 1 Arabidopsis thaliana 0-5 28332148-3 2017 We previously demonstrated that regulation of HSPB5 is mediated by a single conserved histidine over a physiologically relevant pH range of 6.5-7.5. Histidine 86-95 crystallin alpha B Homo sapiens 46-51 8428989-0 1993 Inactivation of the recA protein by mutation of histidine 97 or lysine 248 at the subunit interface. Histidine 48-57 RAD51 recombinase Homo sapiens 20-24 8428989-5 1993 To account for these results, we propose that the mutation of either histidine 97 or lysine 248 alters subunit interactions between recA monomers and that this leads to the loss of cooperative single-stranded DNA binding and DNA pairing activities. Histidine 69-78 RAD51 recombinase Homo sapiens 132-136 8428989-6 1993 This proposal is consistent with the recently determined x-ray structure of the recA protein, which shows that although histidine 97 and lysine 248 are distant from one another in the monomer structure, these two residues are on the opposing complementary faces of the recA subunit and pack against each other at the interface between adjacent recA monomers in the helical filament (Story, R. M., Weber, I. T., and Steitz, T. A. Histidine 120-129 RAD51 recombinase Homo sapiens 80-84 8428624-7 1993 Substitution of Cys-397 of MAO-B, i.e. the residue covalently anchoring FAD, with an Ala or a His residue resulted in the total loss of enzymatic activity, suggesting that the covalent coupling of FAD to MAO occurs specifically at the-SH group of cysteine. Histidine 94-97 monoamine oxidase B Homo sapiens 27-32 27535568-10 2017 In the 0.75 g/kg L-histidine group, a significant increase in the number of Fos-ir cells was detected only in the NTS. Histidine 17-28 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 76-79 28202352-11 2017 We found that SLC38A3 decreased the cellular concentrations of glutamine and histidine, and the deficiency of glutamine or histidine activated PDK1/AKT signaling that in turn, triggered NSCLC metastasis. Histidine 123-132 pyruvate dehydrogenase kinase 1 Homo sapiens 143-147 28380621-13 2017 1 indicated that the SID of His, Lys, and Thr tended ( < 0.10) to be greater in SPC ground to 180 mum than in soybean meal, and the SID of Arg, Ile, Phe, and Trp was greater ( < 0.05) in SPC ground to 70 or 180 mum than in soybean meal. Histidine 28-31 surfactant protein C Sus scrofa 83-86 28088197-8 2017 The methanol inducible promoter AOX1 was used to drive expression of the native and histidine tagged forms of pro-relaxin H2 in dual phase fed-batch experiments on the 22 L scale. Histidine 84-93 relaxin 2 Homo sapiens 110-124 8364225-1 1993 The oncogene GLI is amplified and expressed in some cases of human malignant glioma and undifferentiated childhood sarcoma and is the prototype for a gene family characterized by a highly conserved set of five tandem zinc fingers and a consensus cysteine-histidine link. Histidine 255-264 GLI family zinc finger 1 Homo sapiens 4-16 27928027-3 2016 Ngb is a six-coordinate hemoprotein, with the heme iron coordinated by two histidine residues. Histidine 75-84 neuroglobin Homo sapiens 0-3 8419368-1 1993 Human liver alcohol dehydrogenase isoenzymes beta 1 beta 1 and beta 2 beta 2, in which position 47 in the coenzyme binding domain is an arginine or histidine, respectively, differ remarkably in steady-state kinetics. Histidine 148-157 aldo-keto reductase family 1 member A1 Homo sapiens 12-33 1361949-3 1992 Their mutual repulsion is unfavourable and zinc co-ordination to B10 histidine is necessary to stabilize the well known zinc-containing hexamers. Histidine 69-78 ectonucleotide pyrophosphatase/phosphodiesterase 3 Homo sapiens 65-68 1332958-2 1992 Thyrotropin-releasing hormone, TRH (< Glu-His-Proamide), and [N tau-Me-His]TRH (MeTRH) are present as neutral and positively charged forms at physiologic pH, and it was possible that they bind to the TRH receptor (TRH-R) as charged (protonated) species. Histidine 45-48 thyrotropin releasing hormone Mus musculus 31-34 1332958-2 1992 Thyrotropin-releasing hormone, TRH (< Glu-His-Proamide), and [N tau-Me-His]TRH (MeTRH) are present as neutral and positively charged forms at physiologic pH, and it was possible that they bind to the TRH receptor (TRH-R) as charged (protonated) species. Histidine 74-77 thyrotropin releasing hormone Mus musculus 78-81 1378869-8 1992 KE36-7 bound strongly to the 10-mer peptide-gp46 187-196, and weakly to peptides containing the gp46 amino acid sequence 191-196 (Leu-Pro-His-Ser-Asn-Leu). Histidine 138-141 serpin family H member 1 Homo sapiens 96-100 1535355-5 1992 The kallikrein cleavage points that provided 112 kd and 102 kd two-chain high molecular weight kininogen were after residues 437 (Arg-Lys) and 389 (Arg-Ser), whereas those for plasmin were after 438 (Lys-His) and 389 (Arg-Ser). Histidine 204-207 kallikrein related peptidase 4 Homo sapiens 4-14 27818108-2 2016 In this study the role of His 72 in TmPurL, a glutamine amidotransferase (GAT) enzyme, is investigated. Histidine 26-29 guanine monophosphate synthase Homo sapiens 46-72 27818108-2 2016 In this study the role of His 72 in TmPurL, a glutamine amidotransferase (GAT) enzyme, is investigated. Histidine 26-29 guanine monophosphate synthase Homo sapiens 74-77 27750195-13 2016 As well, it was shown that the extra cellular acidosis led to the protonation of the TRAIL residue histidine by flipping the His switch to the on position with a concomitant decrease in affinity for DR4 and DR5 receptors. Histidine 99-108 major histocompatibility complex, class II, DR beta 4 Homo sapiens 199-202 27543355-0 2016 Circumvention of P-gp and MRP2 mediated efflux of lopinavir by a histidine based dipeptide prodrug. Histidine 65-74 ATP binding cassette subfamily C member 2 Homo sapiens 26-30 1627604-4 1992 The intramolecular binding reaction of the N epsilon of the distal histidine E7 which is observed in methemoglobin in solution cannot be detected in single crystals. Histidine 67-76 hemoglobin subunit gamma 2 Homo sapiens 101-114 27493214-14 2016 Intriguingly, structural analysis showed that a potential His-binding domain was present in the general amino acid sensors GENERAL CONTROL NON-DEREPRESSIBLE2 and PII, suggesting that His may serve as a signal molecule. Histidine 58-61 nitrogen regulatory P-II-like protein Arabidopsis thaliana 131-165 27493214-14 2016 Intriguingly, structural analysis showed that a potential His-binding domain was present in the general amino acid sensors GENERAL CONTROL NON-DEREPRESSIBLE2 and PII, suggesting that His may serve as a signal molecule. Histidine 183-186 nitrogen regulatory P-II-like protein Arabidopsis thaliana 131-165 27546061-9 2016 Electron-nuclear double resonance spectroscopy data exclude histidine or water as axial ligands for ferric DGCR8 and favor bis-thiolate coordination in this form. Histidine 60-69 DGCR8 microprocessor complex subunit Homo sapiens 107-112 1639922-5 1992 The synthetic peptides represented 1-3 multiple repeat units of the 5-residue sequence (Gly-His-His-Pro-His) found in the C-terminal of HRG. Histidine 92-95 histidine rich glycoprotein Homo sapiens 136-139 1639922-5 1992 The synthetic peptides represented 1-3 multiple repeat units of the 5-residue sequence (Gly-His-His-Pro-His) found in the C-terminal of HRG. Histidine 96-99 histidine rich glycoprotein Homo sapiens 136-139 1639922-5 1992 The synthetic peptides represented 1-3 multiple repeat units of the 5-residue sequence (Gly-His-His-Pro-His) found in the C-terminal of HRG. Histidine 96-99 histidine rich glycoprotein Homo sapiens 136-139 1599941-1 1992 The reversible intramolecular binding of the distal histidine side chain to the heme iron in methemoglobin is of special interest due to the very large negative reaction entropy which overcompensates the large reaction enthalpy. Histidine 52-61 hemoglobin subunit gamma 2 Homo sapiens 93-106 1349545-3 1992 The deduced amino acid sequence of ap predicts a homeo domain and a cysteine/histidine-rich domain known as the LIM domain. Histidine 77-86 apterous Drosophila melanogaster 35-37 27431616-4 2016 The order of reactivity of nucleophiles was: Tu > l-Met > l-Cys > l-His > 5"-GMP. Histidine 75-80 5'-nucleotidase, cytosolic II Homo sapiens 89-92 27453504-3 2016 We identify an association between GMPS and xanthosine using single variant analysis and associations between HAL and histidine, PAH and phenylalanine, and UPB1 and ureidopropionate using gene-based tests (P<5 x 10(-8) in meta-analysis), highlighting novel coding variants that may underlie inborn errors of metabolism. Histidine 118-127 histidine ammonia-lyase Homo sapiens 110-113 1349545-3 1992 The deduced amino acid sequence of ap predicts a homeo domain and a cysteine/histidine-rich domain known as the LIM domain. Histidine 77-86 LIM homeobox 1 Drosophila melanogaster 112-115 1547771-1 1992 Human serum response factor (SRF) bearing a histidine tag was expressed using vaccinia virus. Histidine 44-53 serum response factor Homo sapiens 6-27 1547771-1 1992 Human serum response factor (SRF) bearing a histidine tag was expressed using vaccinia virus. Histidine 44-53 serum response factor Homo sapiens 29-32 1537807-8 1992 The cloned DNA restored the ability of a histidase structural gene mutant to grow on L-histidine as the sole nitrogen source. Histidine 85-96 histidine ammonia-lyase Homo sapiens 41-50 1350267-5 1992 These findings suggest that the DR4-specific sequence (Val 11 and His 13 at amino acid positions 11 and 13, respectively), but not particular Dw-associated DR4 sequence, in the first domain of the DRB1 chain contributes to susceptibility to autoimmune hepatitis among Japanese. Histidine 66-69 major histocompatibility complex, class II, DR beta 4 Homo sapiens 32-35 1350267-7 1992 Taken together, these results imply that the basic amino acids at position 13, which is present only on the DR2 and DR4 B1 molecules (Arg on DR2 and His on DR4), are most important for determining the predisposition to autoimmune hepatitis. Histidine 149-152 major histocompatibility complex, class II, DR beta 4 Homo sapiens 116-119 1350267-7 1992 Taken together, these results imply that the basic amino acids at position 13, which is present only on the DR2 and DR4 B1 molecules (Arg on DR2 and His on DR4), are most important for determining the predisposition to autoimmune hepatitis. Histidine 149-152 major histocompatibility complex, class II, DR beta 4 Homo sapiens 156-159 1839890-0 1991 Branched saccharides formed by the action of His-modified cyclodextrin glycosyltransferase from Klebsiella pneumoniae M 5 al on starch. Histidine 45-48 hydroquinone glucosyltransferase-like Solanum tuberosum 71-90 1831223-12 1991 When a histidine residue is present at this amino acid position, hIgG2 dimers do bind efficiently to Fc gamma RII, whereas mIgG1-sensitized E and mAb 41H16 exhibit a strongly diminished binding. Histidine 7-16 LOC105243590 Mus musculus 123-128 1677358-6 1991 In one out of the five subjects with the apoA-IV-1/0 phenotype we identified two point mutations: 1) replacing the positively charged lysine (AAG), amino acid 167, with a negatively charged glutamic acid (GAG), and 2) converting the neutral residue 360, glutamine (CAG), to a positively charged histidine (CAT). Histidine 295-304 N-methylpurine DNA glycosylase Homo sapiens 142-145 1711024-11 1991 This protein is highly homologous with the AroP (general aromatic transport) system of E. coli (59.6% identity) and to a lesser extent with the yeast permeases CAN1 (arginine), PUT4 (proline), and HIP1 (histidine) of Saccharomyces cerevisiae. Histidine 203-212 arginine permease CAN1 Saccharomyces cerevisiae S288C 160-164 1901689-5 1991 We now report the results of sequencing of the entire coding region and exon-intron junctions of TBG-Quebec, which revealed two nucleotide substitutions; one, located in exon 3, changes the normal codon 283 of TTG (leucine) to that of TTT (phenylalanine), and the other, in exon 4, results in the replacement of the normal histidine-331 (CAT) by tyrosine (TAT). Histidine 323-332 serpin family A member 7 Homo sapiens 97-100 1826736-7 1991 Similarly, substitution of residue histidine 51 of the NS3 polyprotein segment, which is predicted to be part of the protease catalytic centre, with an alanine residue, blocks the processing of the polyprotein in vitro. Histidine 35-44 KRAS proto-oncogene, GTPase Homo sapiens 55-58 2005112-2 1991 E2 and E3 are synthesized as a precursor, p62, which is cleaved post-translationally after an Arg-His-Arg-Arg sequence. Histidine 98-101 nucleoporin 62 Homo sapiens 42-45 26931411-7 2016 Cav3.2 channels are modulated by low concentrations of metal ions (nickel, zinc) and redox agents, which involves the histidine 191 (H191) in the channel"s extracellular IS3-IS4 loop. Histidine 118-127 calcium channel, voltage-dependent, T type, alpha 1H subunit Mus musculus 0-6 27013146-5 2016 Three sulfate anions bound to RNase 6 were found, interacting with residues at the main active site (His(15), His(122) and Gln(14)) and cationic surface-exposed residues (His(36), His(39), Arg(66) and His(67)). Histidine 101-104 ribonuclease A family member k6 Homo sapiens 30-37 27013146-5 2016 Three sulfate anions bound to RNase 6 were found, interacting with residues at the main active site (His(15), His(122) and Gln(14)) and cationic surface-exposed residues (His(36), His(39), Arg(66) and His(67)). Histidine 110-113 ribonuclease A family member k6 Homo sapiens 30-37 27013146-5 2016 Three sulfate anions bound to RNase 6 were found, interacting with residues at the main active site (His(15), His(122) and Gln(14)) and cationic surface-exposed residues (His(36), His(39), Arg(66) and His(67)). Histidine 110-113 ribonuclease A family member k6 Homo sapiens 30-37 27013146-5 2016 Three sulfate anions bound to RNase 6 were found, interacting with residues at the main active site (His(15), His(122) and Gln(14)) and cationic surface-exposed residues (His(36), His(39), Arg(66) and His(67)). Histidine 110-113 ribonuclease A family member k6 Homo sapiens 30-37 27013146-5 2016 Three sulfate anions bound to RNase 6 were found, interacting with residues at the main active site (His(15), His(122) and Gln(14)) and cationic surface-exposed residues (His(36), His(39), Arg(66) and His(67)). Histidine 110-113 ribonuclease A family member k6 Homo sapiens 30-37 27013146-9 2016 Interestingly, the RNase 6 crystal structure revealed a novel secondary active site conformed by the His(36)-His(39) dyad that facilitates the polynucleotide substrate catalysis. Histidine 101-104 ribonuclease A family member k6 Homo sapiens 19-26 27013146-9 2016 Interestingly, the RNase 6 crystal structure revealed a novel secondary active site conformed by the His(36)-His(39) dyad that facilitates the polynucleotide substrate catalysis. Histidine 109-112 ribonuclease A family member k6 Homo sapiens 19-26 26928127-3 2016 YPQ1 and AVT1, which are involved in the vacuolar uptake of lysine/arginine and histidine, respectively, were deleted in addition to ypq2Delta and ypq3Delta. Histidine 80-89 cationic amino acid transporter Saccharomyces cerevisiae S288C 0-4 1999399-0 1991 Site-specific mutagenesis of an essential histidine residue in pancreatic cholesterol esterase. Histidine 42-51 carboxyl ester lipase Rattus norvegicus 63-94 1999399-1 1991 The histidine residue essential for the catalytic activity of pancreatic cholesterol esterase (carboxylester lipase) has been identified in this study using sequence comparison and site-specific mutagenesis techniques. Histidine 4-13 carboxyl ester lipase Rattus norvegicus 62-93 1999399-1 1991 The histidine residue essential for the catalytic activity of pancreatic cholesterol esterase (carboxylester lipase) has been identified in this study using sequence comparison and site-specific mutagenesis techniques. Histidine 4-13 carboxyl ester lipase Rattus norvegicus 95-115 1999399-2 1991 In the first approach, comparison of the primary structure of rat pancreatic cholesterol esterase with that of acetylcholinesterase and cholinesterase revealed two conserved histidine residues located at positions 420 and 435. Histidine 174-183 carboxyl ester lipase Rattus norvegicus 66-97 1999399-2 1991 In the first approach, comparison of the primary structure of rat pancreatic cholesterol esterase with that of acetylcholinesterase and cholinesterase revealed two conserved histidine residues located at positions 420 and 435. Histidine 174-183 butyrylcholinesterase Rattus norvegicus 117-131 1999399-5 1991 Based on this sequence homology, it was hypothesized that histidine 435 is the histidine residue essential for catalytic activity of cholesterol esterase. Histidine 58-67 carboxyl ester lipase Rattus norvegicus 133-153 1999399-5 1991 Based on this sequence homology, it was hypothesized that histidine 435 is the histidine residue essential for catalytic activity of cholesterol esterase. Histidine 79-88 carboxyl ester lipase Rattus norvegicus 133-153 1999399-9 1991 The results of this study strongly suggested that histidine 435 may be a component of the catalytic triad of pancreatic cholesterol esterase. Histidine 50-59 carboxyl ester lipase Rattus norvegicus 109-140 27206388-8 2016 hPLSCR1 has five histidine residues and point mutations of histidine residues to alanine in hPLSCR1 resulted in 60 % loss in nuclease activity. Histidine 17-26 phospholipid scramblase 1 Homo sapiens 0-7 27206388-8 2016 hPLSCR1 has five histidine residues and point mutations of histidine residues to alanine in hPLSCR1 resulted in 60 % loss in nuclease activity. Histidine 59-68 phospholipid scramblase 1 Homo sapiens 92-99 27206388-9 2016 Thus histidine residues could play a critical role in the nuclease activity of hPLSCR1. Histidine 5-14 phospholipid scramblase 1 Homo sapiens 79-86 26930370-10 2016 Lactate level was reduced in serum of LGMD-2B patients and histidine was reduced in serum of patients with FSHD as compared to normal subjects. Histidine 59-68 FSHMD1A Homo sapiens 107-111 27018871-1 2016 Human FAM76B (hFAM76B) is a 39 kDa protein that contains homopolymeric histidine tracts, a targeting signal for nuclear speckles. Histidine 71-80 family with sequence similarity 76 member B Homo sapiens 6-12 27018871-1 2016 Human FAM76B (hFAM76B) is a 39 kDa protein that contains homopolymeric histidine tracts, a targeting signal for nuclear speckles. Histidine 71-80 family with sequence similarity 76 member B Homo sapiens 14-21 26694607-4 2016 TgLCAT contains a motif characteristic of serine lipases "AHSLG" and the catalytic triad consisting of serine, aspartate, and histidine (SDH) from LCAT enzymes. Histidine 126-135 lecithin-cholesterol acyltransferase Homo sapiens 2-6 26657319-1 2016 Transition metal-nitrogen/carbon (M-N/C, M = Fe, Co) catalysts are synthesized using environmentally friendly histidine-tag-rich elastin protein beads, metal sulfate and water soluble carbon nanotubes followed by post-annealing and acid leaching processes. Histidine 110-119 elastin Homo sapiens 129-136 26812651-2 2016 Symmetric heteroduplex arises from Holliday junction migration, and we suggest this mechanism explains the high frequency of His+ spores in heteroallelic crosses in which recombination is initiated cis to the his-3 allele further from the initiator, cog+. Histidine 125-128 imidazoleglycerol-phosphate dehydratase HIS3 Saccharomyces cerevisiae S288C 209-214 26812651-3 2016 In contrast, when recombination is initiated cis to the his-3 allele closer to cog+, His+ spores are mainly a result of synthesis-dependent strand annealing, yielding asymmetric heteroduplex. Histidine 85-88 imidazoleglycerol-phosphate dehydratase HIS3 Saccharomyces cerevisiae S288C 56-61 2001710-1 1991 The histidine at position 55 of the amino acid sequence of the Escherichia coli single-stranded DNA binding protein was replaced by tyrosine, glutamic acid, lysine, phenylalanine, and isoleucine. Histidine 4-13 single-stranded DNA-binding protein Escherichia coli 80-115 1943682-2 1991 Histidase (histidine ammonia-lyase, EC 4.3.1.3) catalyzes the deamination of L-histidine to trans-urocanic acid in the liver and skin of mammals. Histidine 77-88 histidine ammonia-lyase Homo sapiens 0-9 1943682-2 1991 Histidase (histidine ammonia-lyase, EC 4.3.1.3) catalyzes the deamination of L-histidine to trans-urocanic acid in the liver and skin of mammals. Histidine 77-88 histidine ammonia-lyase Homo sapiens 11-34 1943682-3 1991 Histidase deficiency results in increased histidine and histamine in blood, and decreased urocanic acid in blood and skin. Histidine 42-51 histidine ammonia-lyase Homo sapiens 0-9 1988934-4 1991 Within this region 58%, 65%, and 50% of the amino acids of PC3 are identical to those of the aligned PC2, furin, and kex2 sequences, respectively, and the catalytically important Asp, His, and Ser residues are all conserved. Histidine 184-187 proprotein convertase subtilisin/kexin type 1 Mus musculus 59-62 2226832-6 1990 Despite these similarities, CAP37 is not a serine proteinase because the active site residues serine and histidine are replaced. Histidine 105-114 azurocidin 1 Homo sapiens 28-33 2249254-4 1990 The amino acid sequences deduced from the ndhH genes show conserved histidine and cysteine residues which are likely to form a metal-binding domain. Histidine 68-77 NADH dehydrogenase 49 kDa subunit Nicotiana tabacum 42-46 24892632-2 2016 The multifunctional oHA conjugates, oHA-histidine-MGK (oHM) carried the pH-sensitive MGK as hydrophobic moieties and oHA as the target of CD44 receptor. Histidine 40-49 CD44 molecule (Indian blood group) Homo sapiens 138-142 26657863-6 2016 Progesterone receptor membrane component-1 (PGRMC1) was required for HIS-dependent increases in hepcidin biosynthesis, as PGRMC1 depletion in cultured hepatoma cells and zebrafish blocked the ability of HISs to increase hepcidin mRNA levels. Histidine 69-72 hepcidin antimicrobial peptide Mus musculus 96-104 26468287-9 2015 The specificity for binding to LC3A/B is due to the interaction between Asp(1285) in FYCO1 and His(57) in LC3B. Histidine 95-98 microtubule associated protein 1 light chain 3 alpha Homo sapiens 31-37 26478267-8 2015 An immunoelectron microscopy assay revealed that MGT5-His is localized to the plasma membrane of the tapetum. Histidine 54-57 magnesium transport 5 Arabidopsis thaliana 49-53 26388194-6 2015 This mutation causes an amino exchange Gln>His at Position 806 located in the calf-2 domain of GPIIb. Histidine 46-49 integrin subunit alpha 2b Homo sapiens 98-103 2176836-9 1990 It confirms that an important feature of the cytochrome c peroxidase structure is at least partial, and probably full, imidazolate character for the proximal histidine (His-175). Histidine 158-167 cytochrome-c peroxidase Saccharomyces cerevisiae S288C 45-68 26081982-11 2015 Thus, reactive metabolites of diabetes upregulate CN1 activity by post-translational modifications, and thus decrease the availability of reactive metabolite-scavenging histidine dipeptides in the kidney in a positive feedback loop. Histidine 169-178 carnosine dipeptidase 1 (metallopeptidase M20 family) Mus musculus 50-53 26409900-2 2015 The multidomain arrangement of HPRG comprises two modules at the N-terminus that are homologous to cystatin but void of cysteine proteinase inhibitor function, and a second half consisting of a histidine-proline-rich region (HPRR) located between two proline-rich regions (PRR1 and PRR2), and a C-terminus domain. Histidine 194-203 histidine rich glycoprotein Homo sapiens 31-35 26593415-3 2015 We synthesized an N-palmitoylated peptide Palm-Val-[Lys-Asn-Lys-Asn-Leu-His-Ser-Pro-(Nle)-Tyr-Phe-Phe71-82]-amide-Palm-Val-(71-82) structurally corresponding to cytoplasmic loop 1 of melanocortin 4 receptor (M4R). Histidine 72-75 melanocortin 4 receptor Rattus norvegicus 183-206 26593415-3 2015 We synthesized an N-palmitoylated peptide Palm-Val-[Lys-Asn-Lys-Asn-Leu-His-Ser-Pro-(Nle)-Tyr-Phe-Phe71-82]-amide-Palm-Val-(71-82) structurally corresponding to cytoplasmic loop 1 of melanocortin 4 receptor (M4R). Histidine 72-75 melanocortin 4 receptor Rattus norvegicus 208-211 26216015-1 2015 Thyrotropin-releasing hormone (TRH)-like peptides were synthesized by replacing critical histidine and pGlu residues in the native peptide. Histidine 89-98 thyrotropin releasing hormone Mus musculus 31-34 26175473-6 2015 Our data raise major concerns about the usage of recombinant His-tagged GM2AP compared with untagged protein. Histidine 61-64 ganglioside GM2 activator Homo sapiens 72-77 26263392-3 2015 We previously demonstrated that NCL changes its action on the human sweet receptor hT1R2-hT1R3 from antagonism to agonism as the pH changes from neutral to acidic values, and that the histidine residues of NCL molecule play critical roles in this pH-dependent functional change. Histidine 184-193 taste 1 receptor member 2 Homo sapiens 83-88 25781680-3 2015 This is exemplified with recombinant his-tagged rhodopsin, which is rapidly extracted from its host membrane and directly assembled into membrane scaffold protein (MSP) nanodiscs. Histidine 1-4 microseminoprotein beta Homo sapiens 137-162 25781680-3 2015 This is exemplified with recombinant his-tagged rhodopsin, which is rapidly extracted from its host membrane and directly assembled into membrane scaffold protein (MSP) nanodiscs. Histidine 1-4 microseminoprotein beta Homo sapiens 164-167 25980622-9 2015 In a protein transduction study, green fluorescence protein fused to the H16 peptide (GFP-H16) was purified by Ni-NTA chromatography, detected using an anti-His-tag antibody and internalized into cells. Histidine 157-160 H1.6 linker histone, cluster member Homo sapiens 73-76 25980622-9 2015 In a protein transduction study, green fluorescence protein fused to the H16 peptide (GFP-H16) was purified by Ni-NTA chromatography, detected using an anti-His-tag antibody and internalized into cells. Histidine 157-160 H1.6 linker histone, cluster member Homo sapiens 90-93 25980622-10 2015 This serial process reveals that H16 functions as a His-tag and protein transduction domain. Histidine 52-55 H1.6 linker histone, cluster member Homo sapiens 33-36 25573590-9 2015 Compared with subjects having ALDH-2 Lys+ with ADH-1B His/His, ORs and 95%CIs for those with ALDH-2 Glu/Glu and ADH-1B His/His was 3.42(0.57-20.38). Histidine 54-57 alcohol dehydrogenase 1B (class I), beta polypeptide Homo sapiens 47-53 25573590-9 2015 Compared with subjects having ALDH-2 Lys+ with ADH-1B His/His, ORs and 95%CIs for those with ALDH-2 Glu/Glu and ADH-1B His/His was 3.42(0.57-20.38). Histidine 54-57 alcohol dehydrogenase 1B (class I), beta polypeptide Homo sapiens 112-118 25573590-9 2015 Compared with subjects having ALDH-2 Lys+ with ADH-1B His/His, ORs and 95%CIs for those with ALDH-2 Glu/Glu and ADH-1B His/His was 3.42(0.57-20.38). Histidine 58-61 alcohol dehydrogenase 1B (class I), beta polypeptide Homo sapiens 47-53 25573590-9 2015 Compared with subjects having ALDH-2 Lys+ with ADH-1B His/His, ORs and 95%CIs for those with ALDH-2 Glu/Glu and ADH-1B His/His was 3.42(0.57-20.38). Histidine 58-61 alcohol dehydrogenase 1B (class I), beta polypeptide Homo sapiens 112-118 25573590-9 2015 Compared with subjects having ALDH-2 Lys+ with ADH-1B His/His, ORs and 95%CIs for those with ALDH-2 Glu/Glu and ADH-1B His/His was 3.42(0.57-20.38). Histidine 58-61 alcohol dehydrogenase 1B (class I), beta polypeptide Homo sapiens 47-53 25573590-9 2015 Compared with subjects having ALDH-2 Lys+ with ADH-1B His/His, ORs and 95%CIs for those with ALDH-2 Glu/Glu and ADH-1B His/His was 3.42(0.57-20.38). Histidine 58-61 alcohol dehydrogenase 1B (class I), beta polypeptide Homo sapiens 112-118 25573590-9 2015 Compared with subjects having ALDH-2 Lys+ with ADH-1B His/His, ORs and 95%CIs for those with ALDH-2 Glu/Glu and ADH-1B His/His was 3.42(0.57-20.38). Histidine 58-61 alcohol dehydrogenase 1B (class I), beta polypeptide Homo sapiens 47-53 25573590-9 2015 Compared with subjects having ALDH-2 Lys+ with ADH-1B His/His, ORs and 95%CIs for those with ALDH-2 Glu/Glu and ADH-1B His/His was 3.42(0.57-20.38). Histidine 58-61 alcohol dehydrogenase 1B (class I), beta polypeptide Homo sapiens 112-118 2176836-9 1990 It confirms that an important feature of the cytochrome c peroxidase structure is at least partial, and probably full, imidazolate character for the proximal histidine (His-175). Histidine 169-172 cytochrome-c peroxidase Saccharomyces cerevisiae S288C 45-68 1696877-4 1990 His-151 and Met-170 were placed in epitopes NA71 and AC8, respectively, whereas His-18 and Met-14 would be involved in the hGH antigenic domain formed by overlapping epitopes 3C11, 10C1, and HG3. Histidine 0-3 adenylate cyclase 8 Homo sapiens 53-56 2118103-0 1990 The molecular characterization of PRP6 and PRP9 yeast genes reveals a new cysteine/histidine motif common to several splicing factors. Histidine 83-92 SF3a splicing factor complex subunit PRP9 Saccharomyces cerevisiae S288C 43-47 2118103-6 1990 Both PRP6 and PRP9 proteins have cysteine/histidine motifs loosely related to those found in zinc finger proteins. Histidine 42-51 SF3a splicing factor complex subunit PRP9 Saccharomyces cerevisiae S288C 14-18 2350181-10 1990 These results suggest that with NEP, binding interactions at the active site involve one or more histidine residues while with thermolysin binding involves an active site glutamic acid residue. Histidine 97-106 membrane metallo-endopeptidase Rattus norvegicus 32-35 1691825-4 1990 In addition, Isl-1, like the lin-11 and mec-3 gene products, contains a novel Cys-His domain which is reminiscent of known metal-binding regions. Histidine 82-85 Protein lin-11 Caenorhabditis elegans 29-35 2404940-8 1990 When this histidine was changed to glutamine, which cannot be phosphorylated, the resulting VirA protein lost both its ability to autophosphorylate and its biological function as a vir gene regulator. Histidine 10-19 two-component VirA-like sensor kinase Agrobacterium tumefaciens 92-96 2321910-6 1990 G6PD Montalbano is a new variant, with nearly normal properties, due to a G----A transition which causes an Arg----His amino acid replacement at position 285. Histidine 115-118 glucose-6-phosphate dehydrogenase Homo sapiens 0-4 33973800-11 2021 Moreover, ClpP and its subunits may act downstream of the histidine utilization pathway, which could be inhibited by bismerthiazol in Xoo. Histidine 58-67 clpP Oryza sativa 10-14 33796530-12 2021 LHPP-mediated histidine dephosphorylation lowered the expression levels of beta-catenin and the cell cycle-related genes CDK4 and CyclinD1, while it up-regulated the cell cycle suppressor genes P21 and P27. Histidine 14-23 catenin (cadherin associated protein), beta 1 Mus musculus 75-87 33796530-12 2021 LHPP-mediated histidine dephosphorylation lowered the expression levels of beta-catenin and the cell cycle-related genes CDK4 and CyclinD1, while it up-regulated the cell cycle suppressor genes P21 and P27. Histidine 14-23 cyclin D1 Mus musculus 130-138 33796530-14 2021 LHPP-mediated histidine dephosphorylation inhibited the self-renewal of ESCs by negatively regulating the Wnt/beta-catenin pathway and downstream cell cycle-related genes, providing a new perspective and regulatory target for ESCs self-renewal. Histidine 14-23 catenin (cadherin associated protein), beta 1 Mus musculus 110-122 34958277-6 2021 We first established an anti-His-tag mAb, HisMab-1 (mouse IgG2b, kappa), by immunizing mice with recombinant proteins containing an N-terminal His-tag. Histidine 29-32 immunoglobulin heavy constant gamma 2B Mus musculus 58-63 34958277-6 2021 We first established an anti-His-tag mAb, HisMab-1 (mouse IgG2b, kappa), by immunizing mice with recombinant proteins containing an N-terminal His-tag. Histidine 143-146 immunoglobulin heavy constant gamma 2B Mus musculus 58-63 34218407-0 2021 METTL9 mediated N1-histidine methylation of zinc transporters is required for tumor growth. Histidine 19-28 methyltransferase like 9 Homo sapiens 0-6 34562450-4 2021 Here we identified mammalian seven-beta-strand methyltransferase METTL9 as a histidine Npi-methyltransferase by siRNA screening coupled with methylhistidine analysis using liquid chromatography-tandem mass spectrometry. Histidine 77-86 methyltransferase like 9 Homo sapiens 65-71 34562450-6 2021 METTL9 does not affect the heterodimer formation of S100A9 and S100A8, although Npi-methylation of S100A9 at His-107 overlaps with a zinc-binding site, attenuating its affinity for zinc. Histidine 109-112 S100 calcium binding protein A9 Homo sapiens 99-105 34627325-17 2021 Molecular docking study further supported that p-hydroxybenzoic acid, cedar acid, shikimic acid, salicylic acid, nicotinic acid, linalool, and histidine can be well binding with NOS3, SRC, PI3K, and AKT. Histidine 143-152 nitric oxide synthase 3 Rattus norvegicus 178-182 34627325-17 2021 Molecular docking study further supported that p-hydroxybenzoic acid, cedar acid, shikimic acid, salicylic acid, nicotinic acid, linalool, and histidine can be well binding with NOS3, SRC, PI3K, and AKT. Histidine 143-152 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 184-187 34544605-5 2022 O2 enters mammalian Mb and the alpha and beta subunits of human HbA through a channel created by upward and outward rotation of the distal His at the E7 helical position, is non-covalently captured in the interior of the distal cavity, and then internally forms a bond with the heme Fe(II) atom. Histidine 139-142 keratin 90, pseudogene Homo sapiens 64-67 25935222-5 2015 For the recognition of each amino acid (here, serine, proline, glycine, asparagine, leucine, and histidine), the corresponding aminoacyl-tRNA synthetase (aaRS) was employed, and multiple enzymatic reactions were combined with a luminol chemiluminescence reaction. Histidine 97-106 alanyl-tRNA synthetase 1 Homo sapiens 127-152 25935222-5 2015 For the recognition of each amino acid (here, serine, proline, glycine, asparagine, leucine, and histidine), the corresponding aminoacyl-tRNA synthetase (aaRS) was employed, and multiple enzymatic reactions were combined with a luminol chemiluminescence reaction. Histidine 97-106 alanyl-tRNA synthetase 1 Homo sapiens 154-158 25701820-0 2015 Two conserved histidines (His490 and His621) on the E2 glycoprotein of hepatitis C virus are critical for CD81-mediated cell entry. Histidine 14-24 CD81 molecule Homo sapiens 106-110 25962097-4 2015 Destabilization by pH or His-104 mutation shifts the ACD from dimer to monomer but also results in a large expansion of HSPB5 oligomer states. Histidine 25-28 crystallin alpha B Homo sapiens 120-125 25597447-6 2015 Results from electron spin-echo envelope modulation and electron-nuclear double resonance experiments reveal that the six Mn(II)-coordinating histidine residues of Ca(II)- and Mn(II)-bound CP are spectroscopically equivalent. Histidine 142-151 carbonic anhydrase 2 Homo sapiens 164-170 25344885-2 2015 In order to determine the host membrane proteins that interact with MSG1, recombinant His-tagged MSG1 (rMSG1) was used to screen for interacting proteins in the protein extracts of porcine erythrocyte membrane. Histidine 86-89 Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1 Rattus norvegicus 68-72 25344885-2 2015 In order to determine the host membrane proteins that interact with MSG1, recombinant His-tagged MSG1 (rMSG1) was used to screen for interacting proteins in the protein extracts of porcine erythrocyte membrane. Histidine 86-89 Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1 Rattus norvegicus 97-101 25344885-2 2015 In order to determine the host membrane proteins that interact with MSG1, recombinant His-tagged MSG1 (rMSG1) was used to screen for interacting proteins in the protein extracts of porcine erythrocyte membrane. Histidine 86-89 Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1 Rattus norvegicus 103-108 25267303-6 2015 In examples of the SUOX-fold and DMSOR-fold enzymes, we observe three types of histidine-containing charge-transfer relays that can: (1) connect the piperazine ring of the pyranopterin to the substrate-binding site (SUOX-fold enzymes); (2) provide inter-pyranopterin communication (DMSOR-fold enzymes); and (3) connect a pyran ring oxygen to deeply buried water molecules (the DMSOR-fold NarGHI-type nitrate reductases). Histidine 79-88 sulfite oxidase Homo sapiens 19-23 25267303-6 2015 In examples of the SUOX-fold and DMSOR-fold enzymes, we observe three types of histidine-containing charge-transfer relays that can: (1) connect the piperazine ring of the pyranopterin to the substrate-binding site (SUOX-fold enzymes); (2) provide inter-pyranopterin communication (DMSOR-fold enzymes); and (3) connect a pyran ring oxygen to deeply buried water molecules (the DMSOR-fold NarGHI-type nitrate reductases). Histidine 79-88 sulfite oxidase Homo sapiens 216-220 25742191-15 2015 In the example presented, the His3 enzyme, which is required for histidine biosynthesis, was fused to Deg1-Sec62. Histidine 65-74 imidazoleglycerol-phosphate dehydratase HIS3 Saccharomyces cerevisiae S288C 30-34 25561737-8 2015 In CAII, binding to MCT1 and MCT4 is mediated by a histidine residue at position 64. Histidine 51-60 carbonic anhydrase 2 S homeolog Xenopus laevis 3-7 25561737-9 2015 Taken together, our results suggest that facilitation of MCT transport activity by CAII requires direct binding between histidine 64 in CAII and a cluster of glutamic acid residues in the C terminus of the transporter that has to be positioned in surroundings that allow access to CAII. Histidine 120-129 carbonic anhydrase 2 S homeolog Xenopus laevis 83-87 25561737-9 2015 Taken together, our results suggest that facilitation of MCT transport activity by CAII requires direct binding between histidine 64 in CAII and a cluster of glutamic acid residues in the C terminus of the transporter that has to be positioned in surroundings that allow access to CAII. Histidine 120-129 carbonic anhydrase 2 S homeolog Xenopus laevis 136-140 25561737-9 2015 Taken together, our results suggest that facilitation of MCT transport activity by CAII requires direct binding between histidine 64 in CAII and a cluster of glutamic acid residues in the C terminus of the transporter that has to be positioned in surroundings that allow access to CAII. Histidine 120-129 carbonic anhydrase 2 S homeolog Xenopus laevis 136-140 34082042-7 2021 Western blot using anti-His tag antibody confirmed the presence of rHC-CS. Histidine 24-27 holocytochrome c synthase Rattus norvegicus 67-73 34312718-9 2021 We observed that B12 and berberine could induce a disparate conformational change in regions Gly250-Asp258 located on the His-RXRalpha/LBD domain. Histidine 122-125 retinoid X receptor alpha Homo sapiens 126-134 35144046-8 2022 In stability studies, (186Re)Re-2 remained intact through 7 d in l-cysteine and l-histidine. Histidine 80-91 G protein-coupled receptor 161 Homo sapiens 29-33 35503584-5 2022 His-BRCC3 plasmid was constructed by cloning the BRCC3 gene into pGEX-6P-1 vector, and then His-BRCC3 fusion protein was induced with isopropyl beta-d-1-thiogalactopyranoside and purified using His-Tag affinity chromatography purification agarose. Histidine 194-197 BRCA1/BRCA2-containing complex subunit 3 Homo sapiens 4-9 35503584-5 2022 His-BRCC3 plasmid was constructed by cloning the BRCC3 gene into pGEX-6P-1 vector, and then His-BRCC3 fusion protein was induced with isopropyl beta-d-1-thiogalactopyranoside and purified using His-Tag affinity chromatography purification agarose. Histidine 194-197 BRCA1/BRCA2-containing complex subunit 3 Homo sapiens 49-54 35503584-5 2022 His-BRCC3 plasmid was constructed by cloning the BRCC3 gene into pGEX-6P-1 vector, and then His-BRCC3 fusion protein was induced with isopropyl beta-d-1-thiogalactopyranoside and purified using His-Tag affinity chromatography purification agarose. Histidine 194-197 BRCA1/BRCA2-containing complex subunit 3 Homo sapiens 96-101 35142326-0 2022 Importance of Ile71 in beta-actin on histidine methyltransferase SETD3 catalysis. Histidine 37-46 POTE ankyrin domain family member F Homo sapiens 23-33 35222471-4 2022 Here, we report that recombinant histidine (His)-AtPTP1 protein activity is directly inhibited by H2O2 and nitric oxide (NO) exogenous treatments. Histidine 33-42 protein tyrosine phosphatase 1 Arabidopsis thaliana 49-55 25652851-6 2015 RESULTS: SDS-PAGE and Western blotting confirmed that a soluble recombinant His-SpiC protein of 19.2 ku was expressed in BL21(DE3) cells. Histidine 76-79 Spi-C transcription factor Homo sapiens 80-84 25652851-7 2015 SPF chicken antibodies against GST-SpiC could recognize His-SpiC, indicating that His-SpiC had a good immunogenicity. Histidine 56-59 Spi-C transcription factor Homo sapiens 35-39 25652851-7 2015 SPF chicken antibodies against GST-SpiC could recognize His-SpiC, indicating that His-SpiC had a good immunogenicity. Histidine 56-59 Spi-C transcription factor Homo sapiens 60-64 25652851-7 2015 SPF chicken antibodies against GST-SpiC could recognize His-SpiC, indicating that His-SpiC had a good immunogenicity. Histidine 56-59 Spi-C transcription factor Homo sapiens 60-64 25652851-7 2015 SPF chicken antibodies against GST-SpiC could recognize His-SpiC, indicating that His-SpiC had a good immunogenicity. Histidine 82-85 Spi-C transcription factor Homo sapiens 35-39 25652851-7 2015 SPF chicken antibodies against GST-SpiC could recognize His-SpiC, indicating that His-SpiC had a good immunogenicity. Histidine 82-85 Spi-C transcription factor Homo sapiens 60-64 25652851-7 2015 SPF chicken antibodies against GST-SpiC could recognize His-SpiC, indicating that His-SpiC had a good immunogenicity. Histidine 82-85 Spi-C transcription factor Homo sapiens 60-64 25652851-9 2015 CONCLUSION: The recombinant His-SpiC was successfully expressed and the indirect ELISA with it as coating antigen could be used as DIVA method for the related vaccine of pullorum disease. Histidine 28-31 Spi-C transcription factor Homo sapiens 32-36 25445692-4 2015 The histidines in the sequence of [D]-H6L9 allowed the peptide to get protonated under pH5.0 (mimicking the lysosome/endosome environment), and strong membrane lytic effect could thus be activated, leading to the escape of liposomes from the lysosomes and the decrease of of mir-10b expression. Histidine 4-14 microRNA 10b Mus musculus 275-282 35222471-4 2022 Here, we report that recombinant histidine (His)-AtPTP1 protein activity is directly inhibited by H2O2 and nitric oxide (NO) exogenous treatments. Histidine 44-47 protein tyrosine phosphatase 1 Arabidopsis thaliana 49-55 35174171-6 2021 Our docking results also revealed that ARG-120, TRP-126, and HIS-187 were critical sites responsible for interaction of SIRT7 with small molecules. Histidine 61-64 sirtuin 7 Homo sapiens 120-125 2558710-3 1989 By use of 500-MHz proton NMR spectroscopy, it has been possible to identify the C-H resonances of the nonaxial histidines of trypsin-solubilized bovine, rabbit, and porcine cytochrome b5 and therefore observe the interaction of DEP with specific histidine residues of cytochrome b5. Histidine 111-121 cytochrome b5 Oryctolagus cuniculus 173-186 2558710-3 1989 By use of 500-MHz proton NMR spectroscopy, it has been possible to identify the C-H resonances of the nonaxial histidines of trypsin-solubilized bovine, rabbit, and porcine cytochrome b5 and therefore observe the interaction of DEP with specific histidine residues of cytochrome b5. Histidine 111-121 cytochrome b5 Oryctolagus cuniculus 268-281 2558710-3 1989 By use of 500-MHz proton NMR spectroscopy, it has been possible to identify the C-H resonances of the nonaxial histidines of trypsin-solubilized bovine, rabbit, and porcine cytochrome b5 and therefore observe the interaction of DEP with specific histidine residues of cytochrome b5. Histidine 111-120 cytochrome b5 Oryctolagus cuniculus 173-186 2558710-3 1989 By use of 500-MHz proton NMR spectroscopy, it has been possible to identify the C-H resonances of the nonaxial histidines of trypsin-solubilized bovine, rabbit, and porcine cytochrome b5 and therefore observe the interaction of DEP with specific histidine residues of cytochrome b5. Histidine 111-120 cytochrome b5 Oryctolagus cuniculus 268-281 2558710-4 1989 In addition, the pKa of the peripheral histidines of bovine and rabbit cytochrome b5 have been measured in D2O. Histidine 39-49 cytochrome b5 Oryctolagus cuniculus 71-84 2614645-1 1989 A novel inhibitor of angiotensin-converting enzyme (ACE) derived from tuna muscle, Pro-Thr-His-Ile-Lys-Trp-Gly-Asp (tuna AI), was chemically synthesized, and its biological properties were investigated. Histidine 91-94 angiotensin-converting enzyme Oryctolagus cuniculus 52-55 2811897-3 1989 The catalytic His and Asp residues tentatively identified in p14 together with the Ser residue of the GDSGG sequence, presumably, constitute the "catalytic triad" characteristic of chymotrypsin-like proteases. Histidine 14-17 ribonuclease P/MRP subunit p14 Homo sapiens 61-64 25550928-7 2014 Overall, a significant association was found between the XPG Asp1104His polymorphism and the risk of gastrointestinal cancers (dominant model: OR = 1.15, 95% CI: 1.05-1.26; His/His vs. Asp/Asp: OR = 1.15, 95% CI: 1.01-1.32). Histidine 68-71 ERCC excision repair 5, endonuclease Homo sapiens 57-60 25160622-4 2014 AtCM1 is activated by tryptophan with phenylalanine and tyrosine acting as negative effectors; however, tryptophan, cysteine, and histidine activate AtCM3. Histidine 130-139 chorismate mutase 3 Arabidopsis thaliana 149-154 25100752-2 2014 In this study, we investigated the pharmacological properties of HIS-388 (N-[(1R,2s,3S,5s,7s)-5-hydroxyadamantan-2-yl]-3-(pyridin-2-yl) isoxazole-4-carboxamide), a newly synthesized 11beta-HSD1 inhibitor, using several mouse models. Histidine 65-68 hydroxysteroid 11-beta dehydrogenase 1 Mus musculus 182-193 24833547-0 2014 Histidine supplementation alleviates inflammation in the adipose tissue of high-fat diet-induced obese rats via the NF-kappaB- and PPARgamma-involved pathways. Histidine 0-9 peroxisome proliferator-activated receptor gamma Rattus norvegicus 131-140 24833547-10 2014 The results also revealed that the expression of adiponectin was markedly increased both in the serum and in the adipose tissue after histidine supplementation, accompanied by the activation of PPARgamma (P= 0 021). Histidine 134-143 adiponectin, C1Q and collagen domain containing Rattus norvegicus 49-60 24833547-10 2014 The results also revealed that the expression of adiponectin was markedly increased both in the serum and in the adipose tissue after histidine supplementation, accompanied by the activation of PPARgamma (P= 0 021). Histidine 134-143 peroxisome proliferator-activated receptor gamma Rattus norvegicus 194-203 24833547-11 2014 These findings indicate that histidine is an effective candidate for ameliorating inflammation and oxidative stress in obese individuals via the NF-kappaB- and PPARgamma-involved pathways. Histidine 29-38 peroxisome proliferator-activated receptor gamma Rattus norvegicus 160-169 25221773-0 2014 In silico study of fragile histidine triad interaction domains with MDM2 and p53. Histidine 27-36 MDM2 proto-oncogene Homo sapiens 68-72 25221773-1 2014 BACKGROUND: Fragile histidine triad (FHIT) is considered as a member of the histidine triad (HIT) nucleotide-binding protein superfamily regarded as a putative tumor suppressor executing crucial role in inhibiting p53 degradation by MDM2. Histidine 20-29 MDM2 proto-oncogene Homo sapiens 233-237 25221773-1 2014 BACKGROUND: Fragile histidine triad (FHIT) is considered as a member of the histidine triad (HIT) nucleotide-binding protein superfamily regarded as a putative tumor suppressor executing crucial role in inhibiting p53 degradation by MDM2. Histidine 76-85 MDM2 proto-oncogene Homo sapiens 233-237 24865971-0 2014 Histidine methylation of yeast ribosomal protein Rpl3p is required for proper 60S subunit assembly. Histidine 0-9 ribosomal 60S subunit protein L3 Saccharomyces cerevisiae S288C 49-54 2542963-12 1989 Comparison of the N2O reductase sequence, determined by translating the structural NosZ gene, with cytochrome c oxidase subunit II sequences from several sources indicates that a Gly-Xaa-Xaa-Xaa-Xaa-Xaa-Cys-Ser-Xaa-Xaa-Cys-Xaa-Xaa-Xaa-His stretch is highly conserved. Histidine 235-238 cytochrome c oxidase subunit II Pseudomonas stutzeri 99-130 2650908-3 1989 Using oligonucleotide probes we have shown that the N-ras gene is activated by a point mutation at the third base of codon 61 resulting in the substitution of histidine for glutamine in the p21 ras gene product. Histidine 159-168 NRAS proto-oncogene, GTPase Homo sapiens 52-57 2539809-7 1989 By analogy with O2-carrying proteins and haem model compounds, the pH-dependent spectral changes of HRP and CCP were interpreted as indicative of the protonation of the N(epsilon) atom of the proximal histidine residue and of the cleavage of the Fe-N(epsilon) bond. Histidine 201-210 cytochrome-c peroxidase Saccharomyces cerevisiae S288C 108-111 2540809-7 1989 Characterization by EPR spectroscopy of the oxochlorin-substituted cytochrome b5 yielded g values of 2.566, 2.375, and 1.756 and respective axial delta/lambda and rhombic V/lambda components of 2.857 and 3.287, indicating significant electronic distortion in the chlorin ring and an increase in electron donation from the axial histidine ligands. Histidine 328-337 cytochrome b5 type A Rattus norvegicus 67-80 2909523-11 1989 In a less active variant of human GH, hGH-V, only 1 residue (His-21) of the 37 residues is replaced by Tyr. Histidine 61-64 growth hormone 2 Homo sapiens 38-43 2849988-8 1988 Sequence comparisons of RSKG-7, RSKG-3, and other kallikrein-related enzymes reveal the key amino acid residues needed for both serine protease activity (His/Asp/Ser) and kallikrein-like cleavage specificity at basic amino acids. Histidine 154-157 kallikrein 1 Rattus norvegicus 24-30 2849988-8 1988 Sequence comparisons of RSKG-7, RSKG-3, and other kallikrein-related enzymes reveal the key amino acid residues needed for both serine protease activity (His/Asp/Ser) and kallikrein-like cleavage specificity at basic amino acids. Histidine 154-157 kallikrein 1-related peptidase C12 Rattus norvegicus 32-38 3233287-1 1988 Possible interactions of the His-12 ring with other side chain and backbone groups of C-peptide lactone (CPL) are discussed. Histidine 29-32 hephaestin Homo sapiens 86-103 24865971-2 2014 In the yeast Saccharomyces cerevisiae, the large ribosomal subunit protein Rpl3p is methylated at histidine 243, a residue that contacts the 25S rRNA near the P site. Histidine 98-107 ribosomal 60S subunit protein L3 Saccharomyces cerevisiae S288C 75-80 25034608-8 2014 The Asp-Phe-Gly (DFG) and His-Arg-Asp (HRD) conserved kinase motif analysis showed the importance of these motifs in IRAK4 kinase activation. Histidine 26-29 interleukin 1 receptor associated kinase 4 Homo sapiens 117-122 3233287-1 1988 Possible interactions of the His-12 ring with other side chain and backbone groups of C-peptide lactone (CPL) are discussed. Histidine 29-32 hephaestin Homo sapiens 105-108 3233287-3 1988 The main new conclusion is that in the helical conformation of CPL, the Phe-8 and His-12 rings are clustered together. Histidine 82-85 hephaestin Homo sapiens 63-66 3233287-4 1988 Studies of Phe-8----Ala analogs of CPL and calculations of ring current effects satisfactorily explain the observed environmental shifts of Phe-8 and His-12 protons in NMR spectra of CPL. Histidine 150-153 hephaestin Homo sapiens 35-38 3233287-4 1988 Studies of Phe-8----Ala analogs of CPL and calculations of ring current effects satisfactorily explain the observed environmental shifts of Phe-8 and His-12 protons in NMR spectra of CPL. Histidine 150-153 hephaestin Homo sapiens 183-186 3065335-11 1988 Key amino acid residues, His(41), Asp(96), and Ser(190), required for catalytic activity and Asp (184) required for kallikrein-type specificity are completely conserved. Histidine 25-28 kallikrein related peptidase 4 Homo sapiens 116-126 2962936-4 1988 Protein sequence studies on peptides generated by trypsin digestion of factor H, purified from pooled plasma from 12 donors, confirmed the presence of both tyrosine and histidine at this position. Histidine 169-178 complement factor H Homo sapiens 71-79 2962936-5 1988 Tyrosine and histidine were observed in a ratio of 2:1, respectively, and therefore this polymorphism is likely to represent a sequence difference between the two most abundant charge variants, FH1 and FH2, of factor H. Histidine 13-22 complement factor H Homo sapiens 210-218 2827651-1 1987 We synthesized a hexapeptide, Gly-His-His-Pro-His-Gly, previously identified as a tandem motif in the histidine-rich glycoprotein (HRG) which has multiple heme-binding sites. Histidine 34-37 histidine rich glycoprotein Homo sapiens 102-129 2827651-1 1987 We synthesized a hexapeptide, Gly-His-His-Pro-His-Gly, previously identified as a tandem motif in the histidine-rich glycoprotein (HRG) which has multiple heme-binding sites. Histidine 34-37 histidine rich glycoprotein Homo sapiens 131-134 3122823-2 1987 The active enzyme contains 227 residues, including three corresponding to the catalytic triad characteristic of serine protease (His-57, Asp-102, and Ser-195 in chymotrypsin). Histidine 129-132 cell division cycle 34, ubiqiutin conjugating enzyme Rattus norvegicus 112-127 3435555-6 1987 It was revealed that polypeptides (Ala-Tyr-Glu)n and (His-Ser-Glu)n possess, in hydrolysis of Z-L-Ala-ONp- and Z-D-Ala-ONp some enantioselectivity with the value of KD/KL 1.3 and 1.17, resp. Histidine 54-57 KIT ligand Homo sapiens 168-172 3302105-7 1987 The N-terminal amino acid sequence of CSF gamma-Aogen was Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-Leu-Leu-Val-Tyr-Ser-Lys-Ser-Ser-(X)-Glu- . Histidine 78-81 colony stimulating factor 2 Canis lupus familiaris 38-41 3478091-0 1987 Evidence for an essential histidine in neutral endopeptidase 24.11. Histidine 26-35 membrane metallo-endopeptidase Rattus norvegicus 39-66 24728193-5 2014 We show that C. glabrata instead initializes histidine degradation via the aromatic amino acid aminotransferase Aro8. Histidine 45-54 bifunctional 2-aminoadipate transaminase/aromatic-amino-acid:2-oxoglutarate transaminase Saccharomyces cerevisiae S288C 112-116 24728193-6 2014 Although ARO8 is also present in S. cerevisiae and is induced by extracellular histidine, the yeast cannot use histidine as its sole nitrogen source, possibly due to growth inhibition by a downstream degradation product. Histidine 79-88 bifunctional 2-aminoadipate transaminase/aromatic-amino-acid:2-oxoglutarate transaminase Saccharomyces cerevisiae S288C 9-13 24728193-6 2014 Although ARO8 is also present in S. cerevisiae and is induced by extracellular histidine, the yeast cannot use histidine as its sole nitrogen source, possibly due to growth inhibition by a downstream degradation product. Histidine 111-120 bifunctional 2-aminoadipate transaminase/aromatic-amino-acid:2-oxoglutarate transaminase Saccharomyces cerevisiae S288C 9-13 24821782-2 2014 Here, we report the identification of a unique cytosolic nucleic acid cosensor in human airway epithelial cells and fibroblasts: DEAH (Asp-Glu-Ala-His) box polypeptide 29 (DHX29), a member of the DExD/H (Asp-Glu-x-Asp/His)-box helicase family. Histidine 147-150 DExH-box helicase 29 Homo sapiens 172-177 24821782-2 2014 Here, we report the identification of a unique cytosolic nucleic acid cosensor in human airway epithelial cells and fibroblasts: DEAH (Asp-Glu-Ala-His) box polypeptide 29 (DHX29), a member of the DExD/H (Asp-Glu-x-Asp/His)-box helicase family. Histidine 218-221 DExH-box helicase 29 Homo sapiens 172-177 24970226-7 2014 XAS on HPRG isolated from the AMPD complex showed that zinc is bound to the protein in a dinuclear cluster where each Zn2+ ion is coordinated by three histidine and one heavier ligand, likely sulfur from cysteine. Histidine 151-160 histidine rich glycoprotein Homo sapiens 7-11 2877746-4 1986 In addition to the prd-specific his-pro repeat, some of the 12 genes contain M-repeats and two new types of homeo boxes not detectable by hybridization with the two known classes of homeo boxes. Histidine 32-35 paired Drosophila melanogaster 19-22 24782176-6 2014 RESULTS: Among the 87 identified studies examining genetic associations with MTX efficacy and toxicity, the reduced folate carrier 1 gene (RFC1) variant 80G>A (Arg(27) His, rs1051266) was selected for random-effects meta-analysis. Histidine 171-174 replication factor C subunit 1 Homo sapiens 139-143 24736652-6 2014 LCAT presents a Ser/Asp/His catalytic triad with a peculiar geometry, which is shared with such other enzyme classes as lipases, proteases and esterases. Histidine 24-27 lecithin-cholesterol acyltransferase Homo sapiens 0-4 23793398-4 2014 Thanks to the versatile affinity interactions between the (NTA)Cu(2+) complex and histidine- or biotin-tagged proteins, both tyrosinase and glucose oxidase were immobilized on the modified electrode. Histidine 82-91 tyrosinase Homo sapiens 125-135 3791584-9 1986 Adenosine deaminase also reduced (by 95%) the atria-to-His-bundle interval prolongation in normoxic recipient hearts caused by the effluent of hypoxic donor hearts. Histidine 55-58 adenosine deaminase Homo sapiens 0-19 3016144-5 1986 However, the tonin activity in hypertensive rats was significantly higher (p less than 0.001) than that in the normotensive rats (His-Leu, 168.7 +/- 10.1 vs. 131.5 +/- 17.3 nmol/min X mg protein). Histidine 130-133 kallikrein 1-related peptidase C2 Rattus norvegicus 13-18 24917394-6 2014 Then, the in silico-based experiments established through molecular docking calculations and scoring, docking search algorithm, and data plotting indicated that ascorbic acid is strong inhibitor of tyrosinase by interacting with four amino acid units (histidine 263, serine 282, phenylalanine 264, and valin 283) in the active site of the enzyme. Histidine 252-261 tyrosinase Homo sapiens 198-208 24492416-4 2014 Remarkably, in full-length STIM1, replacement of Phe-394 with the dimensionally similar but polar histidine head group prevents both Orai1 binding and gating, creating an Orai1 non-agonist. Histidine 98-107 ORAI calcium release-activated calcium modulator 1 Homo sapiens 133-138 24492416-4 2014 Remarkably, in full-length STIM1, replacement of Phe-394 with the dimensionally similar but polar histidine head group prevents both Orai1 binding and gating, creating an Orai1 non-agonist. Histidine 98-107 ORAI calcium release-activated calcium modulator 1 Homo sapiens 171-176 24330471-9 2013 In this study, Rv2135c and Rv0489 from M. tuberculosis were cloned and expressed in Escherichia coli with 6 histidine residues tagged at the C terminal. Histidine 108-117 hypothetical protein Mycobacterium tuberculosis H37Rv 15-22 24129577-7 2013 Second, two glutamic acid residues located on the distal side of the loop collaborate with an invariably conserved histidine on the proximal side of the loop to suppress the pKa of an ionizing species on ubiquitin or Cdc34 which greatly contributes to Cdc34 catalysis. Histidine 115-124 cell division cycle 34, ubiqiutin conjugating enzyme Homo sapiens 217-222 24129577-7 2013 Second, two glutamic acid residues located on the distal side of the loop collaborate with an invariably conserved histidine on the proximal side of the loop to suppress the pKa of an ionizing species on ubiquitin or Cdc34 which greatly contributes to Cdc34 catalysis. Histidine 115-124 cell division cycle 34, ubiqiutin conjugating enzyme Homo sapiens 252-257 23842845-3 2013 One of such substitutions, c.2201G>A in STK10 cDNA, replaces an arginine residue to a histidine (R634H) in the encoded protein. Histidine 89-98 serine/threonine kinase 10 Homo sapiens 43-48 3707967-4 1986 Radioiodination of wheat germ calmodulin, which contains a single tyrosine residue (Tyr-139), showed that only TM2 was labeled by 125I on the Tyr-139 residue and also on the His-108 residue (radiolabeled monoiodotyrosine, diiodotyrosine and monoiodohistidine being present). Histidine 174-177 CaM5 Triticum aestivum 30-40 2945762-3 1986 The homologous sequences are for the most part composed of repeated aa, the most remarkable of which is a Gly-X-His-Y-His motif where X and Y are small, uncharged aa, found six times in the T4 protein and seven times in the lambda ORF314 sequence. Histidine 112-115 tail fiber protein Escherichia virus Lambda 231-237 3911093-4 1985 Cathepsin B hydrolyzed angiotensin I via a dipeptidyl carboxypeptidase mechanism removing His-Leu to form angiotensin II, and it degraded angiotensin II as an endopeptidase at the Val3-Tyr4 bond. Histidine 90-93 cathepsin B Homo sapiens 0-11 4086472-3 1985 Wheat germ calmodulin lacked tryptophan and contained 1 mol each of histidine, tyrosine, cysteine, and N epsilon-trimethyllysine residues per mol of the protein. Histidine 68-77 CaM5 Triticum aestivum 11-21 3018536-2 1985 A strain containing his3-delta 13, an allele which deletes the upstream promoter element but contains the TATA box and intact structural gene, fails to express the gene and consequently is unable to grow in medium lacking histidine. Histidine 222-231 imidazoleglycerol-phosphate dehydratase HIS3 Saccharomyces cerevisiae S288C 20-24 4041423-6 1985 Indirect evidence is adduced that the imidazole pK1 of histidine-57 is greater than or equal to 8.1. Histidine 55-64 prokineticin 1 Homo sapiens 48-51 24005034-3 2013 The immobilization of His6-RAGE domains consists of: (i) formation of a mixed layer of N-acetylcysteamine (NAC) and the thiol derivative of pentetic acid (DPTA); (ii) complexation of Cu(II) by DPTA; (iii) oriented immobilization of His6-RAGE domains via coordination bonds between Cu(II) sites from DPTA-Cu(II) complex and imidazole nitrogen atoms of a histidine tag. Histidine 353-362 advanced glycosylation end-product specific receptor Homo sapiens 27-31 23965744-5 2013 Blocking N-cadherin function using specific peptides that interfere with the histidine-alanine-valine extracellular homophilic interaction domain caused early pathologic changes characterized by disruption of zonula adherens and abnormal intracellular accumulation of N-cadherin. Histidine 77-86 cadherin 2 Homo sapiens 9-19 23965744-5 2013 Blocking N-cadherin function using specific peptides that interfere with the histidine-alanine-valine extracellular homophilic interaction domain caused early pathologic changes characterized by disruption of zonula adherens and abnormal intracellular accumulation of N-cadherin. Histidine 77-86 cadherin 2 Homo sapiens 268-278 3158613-4 1985 This result is the first description of a histidine replacing glutamine in the 61st position and provides further evidence that the 61st amino acid is one of the preferential sites for N-ras activation. Histidine 42-51 NRAS proto-oncogene, GTPase Homo sapiens 185-190 23628156-0 2013 Structures of yeast Apa2 reveal catalytic insights into a canonical AP4A phosphorylase of the histidine triad superfamily. Histidine 94-103 bifunctional AP-4-A phosphorylase/ADP sulfurylase Saccharomyces cerevisiae S288C 20-24 23628156-4 2013 Apa2 is an alpha/beta protein with a core domain of a twisted eight-stranded antiparallel beta-sheet flanked by several alpha-helices, similar to the galactose-1-phosphate uridylyltransferase (GalT) members of the histidine triad (HIT) superfamily. Histidine 214-223 bifunctional AP-4-A phosphorylase/ADP sulfurylase Saccharomyces cerevisiae S288C 0-4 23648837-4 2013 Extensive equilibrium MD simulations with a combined length of over 8 mus demonstrate that histidine protonation, while not accompanied by the loss of structural compactness of the T-domain, nevertheless results in substantial molecular rearrangements characterized by the partial loss of secondary structure due to unfolding of helices TH1 and TH2 and the loss of close contact between the C- and N-terminal segments. Histidine 91-100 negative elongation factor complex member C/D Homo sapiens 337-340 6096811-4 1984 An A----T transversion at codon 61 results in the incorporation of histidine instead of glutamine in the c-K-ras gene product. Histidine 67-76 KRAS proto-oncogene, GTPase Homo sapiens 105-112 6431907-0 1984 A carbon-13 NMR comparative study of metal ion substitutions in human carbonic anhydrase I carboxymethylated at active-site histidine-200. Histidine 124-133 carbonic anhydrase 1 Homo sapiens 70-90 16663647-3 1984 Comparison of trichloroacetic acid (TCA)-soluble products derived from the hydrolysis of hemoglobin showed that carboxyterminal amino acids (histidine, arginine, and tyrosine), are released when extracts from wheat and barley endosperms are used. Histidine 141-150 non-symbiotic hemoglobin Zea mays 89-99 6373642-2 1984 Human [10-asparagine-B] insulin ([ Asn10 -B] insulin), an analogue which differs from the parent molecule in that the histidine residue at position 10 of the B chain (B10) is replaced by asparagine, has been synthesized and isolated in purified form. Histidine 118-127 ectonucleotide pyrophosphatase/phosphodiesterase 3 Homo sapiens 167-170 6373642-5 1984 We have previously shown that the replacement of histidine at position B10 by lysine resulted in an analogue displaying ca. Histidine 49-58 ectonucleotide pyrophosphatase/phosphodiesterase 3 Homo sapiens 71-74 6864333-11 1983 The presence of an intact protein (bovine serum albumin) sharply decreased the ileal absorption of the L-histidine:zinc complex. Histidine 103-114 albumin Rattus norvegicus 42-55 7334672-0 1981 [Measurement of histidase activity in the oral mucous membrane with radioactivity labelled L-histidine (author"s transl)]. Histidine 91-102 histidine ammonia-lyase Homo sapiens 16-25 23785305-3 2013 A heterozygous Arg-to-His missense mutation (p.R930H) in the ribosomal GTPase BMS1 is identified in ACC that is associated with a delay in 18S rRNA maturation, consistent with a role of BMS1 in processing of pre-rRNAs of the small ribosomal subunit. Histidine 22-25 BMS1, ribosome biogenesis factor Mus musculus 78-82 23785305-3 2013 A heterozygous Arg-to-His missense mutation (p.R930H) in the ribosomal GTPase BMS1 is identified in ACC that is associated with a delay in 18S rRNA maturation, consistent with a role of BMS1 in processing of pre-rRNAs of the small ribosomal subunit. Histidine 22-25 BMS1, ribosome biogenesis factor Mus musculus 186-190 23443656-3 2013 Herein, we produced recombinant histidine-tagged Toxoplasma gondii MIF (TgMIF), a 12-kDa protein that lacks oxidoreductase activity but exhibits tautomerase activity with a specific activity of 19.3 mumol/min/mg that cannot be inhibited by the human MIF inhibitor ISO-1. Histidine 32-41 eukaryotic translation initiation factor 1 Homo sapiens 264-269 23525108-5 2013 Stabilizing the C-helix of intact CNGA1 channels by metal binding to a pair of histidines promoted channel opening. Histidine 79-89 cyclic nucleotide gated channel subunit alpha 1 Homo sapiens 34-39 23289972-7 2013 In these binding models, compound 1 may bind into the active site of both isoforms showing important short contacts with the peroxisome proliferator-activated receptor gamma residues: Tyr 473, His 449, Ser 289, His 323; and peroxisome proliferator-activated receptor alpha residues: Tyr 464, His 440, Ser 280 and Tyr 314. Histidine 193-196 peroxisome proliferator-activated receptor gamma Rattus norvegicus 125-173 23355523-5 2013 Disease-causing mutations were identified in three of the probands: a novel single-nucleotide deletion in both KLK4 alleles (g.6930delG; c.245delG; p.Gly82Alafs*87) that shifted the reading frame, a novel missense transition mutation in both MMP20 alleles (g.15390A>G; c.611A>G; p.His204Arg) that substituted arginine for an invariant histidine known to coordinate a structural zinc ion, and a previously described nonsense transition mutation in a single allele of FAM83H (c.1379G>A; g.5663G>A; p.W460*). Histidine 341-350 kallikrein related-peptidase 4 (prostase, enamel matrix, prostate) Mus musculus 111-115 23318883-4 2013 Activation of GCN2 in primary or immortalized human hepatic stellate cells by incubation with medium lacking the essential amino acid histidine correlated with decreased levels of collagen type I protein and mRNA, suggesting an antifibrogenic effect of GCN2. Histidine 134-143 eukaryotic translation initiation factor 2 alpha kinase 4 Homo sapiens 14-18 7282485-13 1981 (3) HDC activity in chick stomach decreased sharply as a function of dietary histidine. Histidine 77-86 histidine decarboxylase Gallus gallus 4-7 7260037-0 1981 Resonance Raman and absorption spectroscopic detection of distal histidine--fluoride interactions in human methemoglobin fluoride and sperm whale metmyoglobin fluoride: measurements of distal histidine ionization constants. Histidine 65-74 hemoglobin subunit gamma 2 Homo sapiens 107-120 23795473-1 2013 Strain MG 1655+hisGr hisL"-Delta, purR, which produces histidine with a weight yield of approximately 12% from glucose, was constructed through directed chromosomal modifications of the laboratory Escherichia coli strain MG 1655+, which has a known genome sequence. Histidine 55-64 DNA-binding transcriptional repressor PurR Escherichia coli str. K-12 substr. MG1655 34-38 23390665-3 2004 It shares an identical C-terminal region (-Trp-Ala-Val-Gly-His-Leu-Met-NH2) with gastrin-releasing peptide (GRP), which is responsible for receptor binding and signal transduction (4, 5). Histidine 59-62 gastrin releasing peptide Homo sapiens 81-106 23390665-3 2004 It shares an identical C-terminal region (-Trp-Ala-Val-Gly-His-Leu-Met-NH2) with gastrin-releasing peptide (GRP), which is responsible for receptor binding and signal transduction (4, 5). Histidine 59-62 gastrin releasing peptide Homo sapiens 108-111 23249163-1 2013 We report the functional analysis of an artificial hexacoordinate oxygen transport protein, HP7, which operates via a mechanism similar to that of human neuroglobin and cytoglobin: the destabilization of one of two heme-ligating histidine residues. Histidine 229-238 neuroglobin Homo sapiens 153-164 23276281-4 2013 We demonstrate that the unusual His(4) motif (site 2) formed at the S100A8/S100A9 dimer interface is the site of high-affinity Mn(II) coordination. Histidine 32-35 S100 calcium binding protein A9 Homo sapiens 75-81 23022039-2 2013 More than one third of the mammalian PLA(2) enzymes belong to the secreted PLA(2) (sPLA(2)) family, which consists of low molecular mass, Ca(2+)-requiring enzymes with a His-Asp catalytic dyad. Histidine 170-173 phospholipase A2 group IIA Homo sapiens 83-90 23469063-8 2013 Chimeras between NL4-3 and LAI Vif identify the amino acid responsible for the differential degradation activity: A histidine at position 48 in Vif confers activity against A3H-hapII, while an asparagine abolishes its anti-A3H activity. Histidine 116-125 Vif Human immunodeficiency virus 1 31-34 23469063-8 2013 Chimeras between NL4-3 and LAI Vif identify the amino acid responsible for the differential degradation activity: A histidine at position 48 in Vif confers activity against A3H-hapII, while an asparagine abolishes its anti-A3H activity. Histidine 116-125 Vif Human immunodeficiency virus 1 144-147 6790399-5 1981 In a case of 5 year-old boy with clinical histidinemia, in whom serum histidine level was 12.1 mg/kl, histidase activity of stratum corneum was not detectable, FIGLU and urocanic acid in urine and urocanic acid in sweat were not detected, the half life of histidine at intravenous histidine loading test was too long to measure. Histidine 42-51 histidine ammonia-lyase Homo sapiens 102-111 23044417-3 2012 Previously, we discovered through a screen of ethylnitrosourea- (ENU-) mutagenized mice that substitution of the latter of these tyrosines with histidine (Y344H) of the murine Sec61alpha protein results in diabetes and hepatic steatosis in mice that is a result of ER stress. Histidine 144-153 Sec61 alpha 1 subunit (S. cerevisiae) Mus musculus 176-186 22766396-0 2012 The histidine-loop is essential for transport activity of human MDR3. Histidine 4-13 ATP binding cassette subfamily B member 4 Homo sapiens 64-68 22766396-3 2012 Here we report the first patient with a mutation of the putative histidine-loop of a human ABC transporter, the multi drug resistance protein 3 (MDR3). Histidine 65-74 ATP binding cassette subfamily B member 4 Homo sapiens 112-143 22766396-3 2012 Here we report the first patient with a mutation of the putative histidine-loop of a human ABC transporter, the multi drug resistance protein 3 (MDR3). Histidine 65-74 ATP binding cassette subfamily B member 4 Homo sapiens 145-149 22766396-7 2012 As shown by sequence alignment, this amino acid corresponds to the highly conserved histidine of the "H-loop", which is critical for ATP-hydrolysis, suggesting an essential role of histidine 1231 of human MDR3. Histidine 84-93 ATP binding cassette subfamily B member 4 Homo sapiens 205-209 22766396-7 2012 As shown by sequence alignment, this amino acid corresponds to the highly conserved histidine of the "H-loop", which is critical for ATP-hydrolysis, suggesting an essential role of histidine 1231 of human MDR3. Histidine 181-190 ATP binding cassette subfamily B member 4 Homo sapiens 205-209 22577880-2 2012 Copper-ATPase ATP7A is unique in having a sequence rich in histidine and methionine residues located on the lumenal side of the membrane. Histidine 59-68 ATPase copper transporting alpha Homo sapiens 14-19 22561016-3 2012 The over-expressed protein was identified with mOCTN3 by anti-His antibody and reconstitution in liposomes. Histidine 62-65 solute carrier family 22 (organic cation transporter), member 21 Mus musculus 47-53 22612077-8 2012 In our calculation on the special pair radical cation, we show that the coordinating histidine residues reduce the spin-density asymmetry between the two halves of this system, while inclusion of a larger binding pocket model increases this asymmetry. Histidine 85-94 spindlin 1 Homo sapiens 115-119 22486179-1 2012 We use a host-guest approach to evaluate the effect of Trp guest residues relative to Ala on the kinetics and thermodynamics of formation of His-heme loops in the denatured state of iso-1-cytochrome c at 1.5, 3.0, and 6.0 M guanidine hydrochloride (GdnHCl). Histidine 141-144 eukaryotic translation initiation factor 1 Homo sapiens 182-187 22486179-2 2012 Trp guest residues are inserted into an alanine-rich segment placed after a unique His near the N-terminus of iso-1-cytochrome c. Histidine 83-86 eukaryotic translation initiation factor 1 Homo sapiens 110-115 6968751-3 1980 The porcine C3a octapeptide is 3 times more active than the common pentapeptide, but the human octapeptide (Ala(70)-Ser-His-Leu(73)-Gly-Leu(75)-Ala-Arg(77) is 12 times more active than the pentapeptide. Histidine 120-123 complement C3 Homo sapiens 12-15 6968751-5 1980 Thus, the increased activity of the human C3a octapeptide over the pentapeptide appears to be related to the backbone of residues 70 to 72 and is not due to the presence of the hydroxyl group of serine-71, the imidazole ring of histidine-72, or a positive charge at or near the NH2 terminus. Histidine 228-237 complement C3 Homo sapiens 42-45 6900508-0 1980 Proton nuclear magnetic resonance study on the roles of histidine residues in the binding of polypeptide chain elongation factor Tu from Thermus thermophilus with aminoacyl transfer ribonucleic acid and guanine nucleotides. Histidine 56-65 elongation factor Tu Thermus thermophilus HB8 111-131 22222112-3 2012 The deduced GhAGP31 protein contains the conserved features of non-classical AGPs: a putative signal peptide, N-terminal histidine-rich stretch, middle repetitive proline-rich domain and a cysteine-containing "PAC" domain. Histidine 121-130 non-classical arabinogalactan protein 31-like Gossypium hirsutum 12-19 22419824-10 2012 The absorption spectrum of the reconstituted BoWSCP-His was identical to that of the native BoWSCP. Histidine 52-55 kunitz-type trypsin inhibitor-like 1 protein Brassica oleracea 45-51 22419824-10 2012 The absorption spectrum of the reconstituted BoWSCP-His was identical to that of the native BoWSCP. Histidine 52-55 kunitz-type trypsin inhibitor-like 1 protein Brassica oleracea 92-98 22419824-11 2012 Chl binding analyses of BoWSCP-His revealed that the BoWSCP-His bound both Chl a and Chl b with almost the same affinity in 40% methanol solution, although the native BoWSCP had a higher content of Chl a. Histidine 31-34 kunitz-type trypsin inhibitor-like 1 protein Brassica oleracea 24-30 22419824-11 2012 Chl binding analyses of BoWSCP-His revealed that the BoWSCP-His bound both Chl a and Chl b with almost the same affinity in 40% methanol solution, although the native BoWSCP had a higher content of Chl a. Histidine 31-34 kunitz-type trypsin inhibitor-like 1 protein Brassica oleracea 53-59 22419824-11 2012 Chl binding analyses of BoWSCP-His revealed that the BoWSCP-His bound both Chl a and Chl b with almost the same affinity in 40% methanol solution, although the native BoWSCP had a higher content of Chl a. Histidine 31-34 kunitz-type trypsin inhibitor-like 1 protein Brassica oleracea 53-59 22417133-2 2012 This histidine-rich elastin-like polypeptide block copolymer self-assembles at 37 C into spherical micelles that are stabilized by Zn(2+) and are disrupted as the pH drops from 7.4 to 6.4. Histidine 5-14 elastin Homo sapiens 20-27 6900508-7 1980 A hydrogen-deuterium exchange experiment was carried out on the histidine C2 protons of free EF-Tu, and the previous assignments of C2 proton signals were revised in part. Histidine 64-73 elongation factor Tu Thermus thermophilus HB8 93-98 6900508-8 1980 An analysis of the 1H NMR spectra of EF-Tu photooxidized under various conditions indicates that a histidine residue is located in the aminoacyl-tRNA binding site and is probably essential for the binding with aminoacyl-tRNA. Histidine 99-108 elongation factor Tu Thermus thermophilus HB8 37-42 6900508-10 1980 Furthermore, the effect of paramagnetic hexacyanochromate(III) ion on the 1H NMR spectra of free EF-Tu suggests that another histidine residue lies near the guanine nucleotide binding site. Histidine 125-134 elongation factor Tu Thermus thermophilus HB8 97-102 7352984-5 1980 A model study of the azide-methemoglobin complex suggested that the increase of the high-spin character of the beta heme iron is due to a conformational change of the proximal histidine which weakens the interaction between the heme iron and the proximal base. Histidine 176-185 hemoglobin subunit gamma 2 Homo sapiens 27-40 476954-1 1979 A new sensitive method was developed for assay of histidase in the stratum corneum of human skin with [14C] histidine as substrate. Histidine 108-117 histidine ammonia-lyase Homo sapiens 50-59 207308-2 1978 3-SLHis-105-RNase A is an active derivative of ribonuclease A (RNase A) spin-labeled at the 3 position of the imidazole ring of histidine-105. Histidine 128-137 spindlin 1 Homo sapiens 72-76 207308-4 1978 The results of these experiments indicate that the spin-label attached to histidine-105 of RNase A is sensitive to modifications affecting the conformational integrity of the molecule and to the reconstituting effects of various active-center ligands. Histidine 74-83 spindlin 1 Homo sapiens 51-55 656435-0 1978 An essential active-site histidine residue in human prostatic acid phosphatase. Histidine 25-34 acid phosphatase 3 Homo sapiens 52-78 22278351-0 2012 In vivo imaging of radiation-induced tissue apoptosis by (99m)Tc(I)-his (6)-annexin A5. Histidine 68-71 annexin A5 Mus musculus 85-95 22278351-1 2012 OBJECTIVE: A recombinant annexin A5 with the N-terminal extension of six histidine residues was labeled with (99m)Tc(I)-tricarbonyl ion to produce the (99m)Tc-labeled annexin A5, referred to (99m)Tc(I)-his(6)-annexin A5. Histidine 73-82 annexin A5 Mus musculus 25-35 22469241-0 2012 Single-photon emission computed tomographic imaging of the early time course of therapy-induced cell death using technetium 99m tricarbonyl His-annexin A5 in a colorectal cancer xenograft model. Histidine 140-143 annexin A5 Mus musculus 144-154 22469241-1 2012 As apoptosis occurs over an interval of time after administration of apoptosis-inducing therapy in tumors, the changes in technetium 99m ((99m)Tc)-tricarbonyl (CO)3 His-annexin A5 (His-ann A5) accumulation over time were examined. Histidine 165-168 annexin A5 Mus musculus 169-179 22469241-1 2012 As apoptosis occurs over an interval of time after administration of apoptosis-inducing therapy in tumors, the changes in technetium 99m ((99m)Tc)-tricarbonyl (CO)3 His-annexin A5 (His-ann A5) accumulation over time were examined. Histidine 181-184 annexin A5 Mus musculus 169-179 22306030-9 2012 Taken together, these observations are consistent with an important role that neuronal HIS may play in mediating the potent effects of AMN+LEP on food intake and body weight. Histidine 87-90 amnion associated transmembrane protein Rattus norvegicus 135-142 22437718-1 2012 The enzyme tyrosinase contains two Cu(I) centres, trigonally coordinated by imidazole nitrogens of six conserved histidine residues. Histidine 113-122 tyrosinase Homo sapiens 11-21 22242765-11 2012 Finally, labeling of hZIP4 with maleimide or diethylpyrocarbonate indicates that extracellularly accessible histidine, but not cysteine, residues are required, either directly or indirectly, for cation uptake. Histidine 108-117 solute carrier family 39 member 4 Homo sapiens 21-26 22242893-0 2012 Role of individual histidines in the pH-dependent global stability of human chloride intracellular channel 1. Histidine 19-29 chloride intracellular channel 1 Homo sapiens 76-108 22242893-3 2012 We systematically mutated each of the three histidine residues in CLIC1 to an alanine at position 74 and a phenylalanine at positions 185 and 207. Histidine 44-53 chloride intracellular channel 1 Homo sapiens 66-71 22242893-4 2012 We examined the effect of the histidine-mediated pH dependence on the structure and global stability of CLIC1. Histidine 30-39 chloride intracellular channel 1 Homo sapiens 104-109 22919744-5 2012 RESULTS: The recombinant protein 6 x His-VP2 was produced in a larger quantity at 25 degrees C induced by IPTG (1 mmol/L) over night and purified by Ni-NTA column. Histidine 37-40 VP2 Primate bocaparvovirus 1 41-44 22155078-1 2012 Tyrosyl-DNA phosphodiesterase I (Tdp1) is a member of the phospholipase D superfamily that hydrolyzes 3"-phospho-DNA adducts via two conserved catalytic histidines-one acting as the lead nucleophile and the second acting as a general acid/base. Histidine 153-163 phospholipase D Saccharomyces cerevisiae S288C 58-73 22904671-6 2012 Each monomer of the Aqy1 tetramers forms a channel whose walls consist mostly of hydrophilic residues, transporting through the selectivity filter containing Arg-227, His-212, Phe-92, and Ala-221, and the two conserved Asn-Pro-Ala (NPA) motifs containing asparagines 224 and 112. Histidine 167-170 Aqy1p Saccharomyces cerevisiae S288C 20-24 22408443-11 2012 The RPL23A gene can be really expressed in E. coli and the RPL23A protein, fusioned with the N-terminally His-tagged protein, gave rise to the accumulation of an expected 22 KDa polypeptide. Histidine 106-109 60S ribosomal protein L23a Ailuropoda melanoleuca 4-10 22408443-11 2012 The RPL23A gene can be really expressed in E. coli and the RPL23A protein, fusioned with the N-terminally His-tagged protein, gave rise to the accumulation of an expected 22 KDa polypeptide. Histidine 106-109 60S ribosomal protein L23a Ailuropoda melanoleuca 59-65 22837806-5 2012 We then used recombinant His-tagged 14-3-3zeta to pull-down interacting proteins from the mouse hippocampus followed by identification by liquid chromatography-mass spectrometry. Histidine 25-28 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide Mus musculus 36-46 22350878-3 2012 The protocols include purification of the SUMO E1 enzyme His-Aos1/Uba2, untagged E2 enzyme Ubc9, untagged SUMO, and the RanBP2 E3 ligase fragment IR1 + M. Using these components, we provide step-by-step instructions to set up sumoylation reactions. Histidine 57-60 SUMO1 activating enzyme subunit 1 Homo sapiens 61-65 21965683-2 2011 Most of the neuroglobin is present in a hexacoordinate state with proximal and distal histidines in the heme pocket directly bound to the heme iron. Histidine 86-96 neuroglobin Homo sapiens 12-23 21956104-1 2011 In the Saccharomyces cerevisiae actin-profilin interface, Ala(167) of the actin barbed end W-loop and His(372) near the C terminus form a clamp around a profilin segment containing residue Arg(81) and Tyr(79). Histidine 102-105 profilin Saccharomyces cerevisiae S288C 38-46 21956104-1 2011 In the Saccharomyces cerevisiae actin-profilin interface, Ala(167) of the actin barbed end W-loop and His(372) near the C terminus form a clamp around a profilin segment containing residue Arg(81) and Tyr(79). Histidine 102-105 profilin Saccharomyces cerevisiae S288C 153-161 21864500-2 2011 To complement structural information available, we produced the FAD-containing monooxygenase-like domain of human MICAL-1 (MICAL-MO) in forms differing for the presence and location of a His-tag, which only influences the protein yields. Histidine 187-190 microtubule associated monooxygenase, calponin and LIM domain containing 1 Homo sapiens 114-121 21864500-2 2011 To complement structural information available, we produced the FAD-containing monooxygenase-like domain of human MICAL-1 (MICAL-MO) in forms differing for the presence and location of a His-tag, which only influences the protein yields. Histidine 187-190 microtubule associated monooxygenase, calponin and LIM domain containing 1 Homo sapiens 114-119 22045708-0 2011 (99)mTc-(CO)(3) His-annexin A5 micro-SPECT demonstrates increased cell death by irinotecan during the vascular normalization window caused by bevacizumab. Histidine 16-19 annexin A5 Mus musculus 20-30 22045708-6 2011 The apoptosis-detecting radiotracer (99m)Tc-(CO)(3) His-annexin A5 was injected (18.5 MBq) in mice 12, 24, and 48 h after the start of the irinotecan or NaCl treatment, and micro-SPECT was subsequently performed 3.5 h after injection of the radiotracer. Histidine 52-55 annexin A5 Mus musculus 56-66 21866897-10 2011 Surprisingly, mutant NP2(V24E) turned out to be particularly similar in behavior to sGC; i.e., the Fe(II)-His bond is sensitive to breakage upon NO binding, whereas the unliganded form binds the proximal His at neutral pH. Histidine 106-109 neuropilin 2 Homo sapiens 21-25 21866897-10 2011 Surprisingly, mutant NP2(V24E) turned out to be particularly similar in behavior to sGC; i.e., the Fe(II)-His bond is sensitive to breakage upon NO binding, whereas the unliganded form binds the proximal His at neutral pH. Histidine 204-207 neuropilin 2 Homo sapiens 21-25 21866897-11 2011 To the best of our knowledge, NP2(V24E) is the first example in which the ability to use the His-on His-off switch was engineered into a heme protein by site-directed mutagenesis other than the proximal His itself. Histidine 93-96 neuropilin 2 Homo sapiens 30-34 21866897-11 2011 To the best of our knowledge, NP2(V24E) is the first example in which the ability to use the His-on His-off switch was engineered into a heme protein by site-directed mutagenesis other than the proximal His itself. Histidine 102-105 neuropilin 2 Homo sapiens 30-34 21866897-11 2011 To the best of our knowledge, NP2(V24E) is the first example in which the ability to use the His-on His-off switch was engineered into a heme protein by site-directed mutagenesis other than the proximal His itself. Histidine 102-105 neuropilin 2 Homo sapiens 30-34 21765407-1 2011 We obtained unanticipated synthetic byproducts from alkylation of the delta(1) nitrogen (N3) of the histidine imidazole ring of the polo-like kinase-1 (Plk1) polo-box domain (PBD)-binding peptide PLHSpT. Histidine 100-109 polo like kinase 1 Homo sapiens 132-150 21765407-1 2011 We obtained unanticipated synthetic byproducts from alkylation of the delta(1) nitrogen (N3) of the histidine imidazole ring of the polo-like kinase-1 (Plk1) polo-box domain (PBD)-binding peptide PLHSpT. Histidine 100-109 polo like kinase 1 Homo sapiens 152-156 24250389-10 2011 The yield of hepcidin in BES was 20 mug/mL and anti-histidine (anti-His) tag antibody was used for the confirmation of hepcidin on western blot nitrocellulose paper. Histidine 52-61 hepcidin antimicrobial peptide Mus musculus 119-127 24250389-10 2011 The yield of hepcidin in BES was 20 mug/mL and anti-histidine (anti-His) tag antibody was used for the confirmation of hepcidin on western blot nitrocellulose paper. Histidine 68-71 hepcidin antimicrobial peptide Mus musculus 119-127 21398639-7 2011 Placing the SAE3 and PCH2 introns within a HIS3 reporter confers Tgs1-dependent histidine prototrophy, signifying that the respective introns are portable determinants of TMG-dependent gene expression. Histidine 80-89 Sae3p Saccharomyces cerevisiae S288C 12-16 21398639-7 2011 Placing the SAE3 and PCH2 introns within a HIS3 reporter confers Tgs1-dependent histidine prototrophy, signifying that the respective introns are portable determinants of TMG-dependent gene expression. Histidine 80-89 imidazoleglycerol-phosphate dehydratase HIS3 Saccharomyces cerevisiae S288C 43-47 680433-4 1978 The His-Purkinje (HV interval) and intraventicular (QRS interval) conduction times are prolonged (P less than 0.001), as well as the RRF of His-Purkinje system. Histidine 140-143 mitochondrial ribosome recycling factor Homo sapiens 133-136 16641-1 1977 Human carbonic anhydrase B (HCAB), prepared by a new affinity chromatography procedure, was carboxymethylated exclusively at NT of its active-site histidine-200 using 90% [1-13C]bromoacetate. Histidine 147-156 carbonic anhydrase 2 Homo sapiens 6-26 21289295-0 2011 A histidine-rich motif mediates mitochondrial localization of ZnT2 to modulate mitochondrial function. Histidine 2-11 solute carrier family 30 member 2 Homo sapiens 62-66 21289295-7 2011 Confocal microscopy of truncated and point mutants of ZnT2-green fluorescent protein (GFP) fusion proteins revealed a histidine-rich motif ((51)HHXH(54)) in the NH(2) terminus that is important for mitochondrial targeting of ZnT2. Histidine 118-127 solute carrier family 30 member 2 Homo sapiens 54-58 21289295-7 2011 Confocal microscopy of truncated and point mutants of ZnT2-green fluorescent protein (GFP) fusion proteins revealed a histidine-rich motif ((51)HHXH(54)) in the NH(2) terminus that is important for mitochondrial targeting of ZnT2. Histidine 118-127 solute carrier family 30 member 2 Homo sapiens 225-229 21390047-4 2011 Indeed, the univariate hazard ratio (HR) was 2.8 times higher for patients with ERCC5 1104 His/His (P<0.001) compared with ERCC5 1104 Asp/Asp. Histidine 91-94 ERCC excision repair 5, endonuclease Homo sapiens 80-85 21390047-4 2011 Indeed, the univariate hazard ratio (HR) was 2.8 times higher for patients with ERCC5 1104 His/His (P<0.001) compared with ERCC5 1104 Asp/Asp. Histidine 95-98 ERCC excision repair 5, endonuclease Homo sapiens 80-85 21390047-5 2011 Accordingly, the 5-year survival rate was 55% (95% confidence interval 43-71) for patients with ERCC5 1104 His/His, whereas 82% (95% confidence interval 78-86) of patients with ERCC5 1104 Asp/Asp were still alive at this time. Histidine 107-110 ERCC excision repair 5, endonuclease Homo sapiens 96-101 21277849-8 2011 Increased lysosomal histidine, in the absence of SLC15A4, appears to negatively regulate Toll-like receptor 9 function by inhibiting the proteolytic activities of cathepsins B and L. SLC15A4(-/-) mice also had a severe defect in NOD1-dependent cytokine production, indicating that SLC15A4 functions as a transporter of the NOD1 ligand. Histidine 20-29 toll-like receptor 9 Mus musculus 89-109 20960216-9 2011 Moreover, the partial rescue of the impl2 phenotype by histidine application implies that IMPL2 is also involved in histidine biosynthesis during embryo development. Histidine 55-64 inositol monophosphatase family protein Arabidopsis thaliana 36-41 20960216-9 2011 Moreover, the partial rescue of the impl2 phenotype by histidine application implies that IMPL2 is also involved in histidine biosynthesis during embryo development. Histidine 55-64 inositol monophosphatase family protein Arabidopsis thaliana 90-95 20960216-9 2011 Moreover, the partial rescue of the impl2 phenotype by histidine application implies that IMPL2 is also involved in histidine biosynthesis during embryo development. Histidine 116-125 inositol monophosphatase family protein Arabidopsis thaliana 36-41 20960216-9 2011 Moreover, the partial rescue of the impl2 phenotype by histidine application implies that IMPL2 is also involved in histidine biosynthesis during embryo development. Histidine 116-125 inositol monophosphatase family protein Arabidopsis thaliana 90-95 21332165-2 2011 With respect to other globins similar to myoglobin, Ngb displays some peculiarities as the topological reorganization of the internal cavities coupled to the sliding of the heme, or the binding of the endogenous distal histidine to the heme in the absence of an exogenous ligand. Histidine 219-228 neuroglobin Homo sapiens 52-55 849244-5 1977 This can be explained by the alkylation of the epsilon-amino of lysine residue beta76, but some evidence for the alkylation of histidine in the minor band of Hbb-p is also presented. Histidine 127-136 hemoglobin beta chain complex Mus musculus 158-161 14120-10 1976 3"-GMP and guanosine showed some protective effect against loss of activity and of histidine residues. Histidine 83-92 5'-nucleotidase, cytosolic II Homo sapiens 3-6 21455490-5 2011 C. elegans haly-1 encodes a protein that is homologous to vertebrate HAL, an enzyme that converts histidine to urocanic acid. Histidine 98-107 Histidine ammonia-lyase Caenorhabditis elegans 11-17 21455490-6 2011 haly-1 mutant animals displayed elevated levels of histidine, indicating that C. elegans HALY-1 protein is an enzyme involved in histidine catabolism. Histidine 51-60 Histidine ammonia-lyase Caenorhabditis elegans 0-6 21455490-6 2011 haly-1 mutant animals displayed elevated levels of histidine, indicating that C. elegans HALY-1 protein is an enzyme involved in histidine catabolism. Histidine 51-60 Histidine ammonia-lyase Caenorhabditis elegans 89-95 21455490-6 2011 haly-1 mutant animals displayed elevated levels of histidine, indicating that C. elegans HALY-1 protein is an enzyme involved in histidine catabolism. Histidine 129-138 Histidine ammonia-lyase Caenorhabditis elegans 0-6 21455490-6 2011 haly-1 mutant animals displayed elevated levels of histidine, indicating that C. elegans HALY-1 protein is an enzyme involved in histidine catabolism. Histidine 129-138 Histidine ammonia-lyase Caenorhabditis elegans 89-95 20083497-2 2011 The histidine (position 41) in the conserved sequence TAAHC is mutated to serine and this sequence (TAASC) plays a crucial role when HBP binds to monocytes. Histidine 4-13 azurocidin 1 Homo sapiens 133-136 21290626-0 2004 3-Cyano-4-[(18)F]fluoro-benzoyl-Arg-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2 3-Cyano-4-[(18)F]fluoro-benzoyl-Arg-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2, abbreviated as [(18)F]6b, is a bombesin (BN)-based (18)F-labeled peptide synthesized by Mu et al. Histidine 63-66 gastrin releasing peptide Homo sapiens 190-198 21290626-0 2004 3-Cyano-4-[(18)F]fluoro-benzoyl-Arg-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2 3-Cyano-4-[(18)F]fluoro-benzoyl-Arg-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2, abbreviated as [(18)F]6b, is a bombesin (BN)-based (18)F-labeled peptide synthesized by Mu et al. Histidine 142-145 gastrin releasing peptide Homo sapiens 190-198 21290627-0 2004 3-Cyano-4-[(18)F]fluoro-benzoyl-Ala(SO3H)-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2 3-Cyano-4-[(18)F]fluoro-benzoyl-Ala(SO3H)-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2, abbreviated as [(18)F]7b, is a bombesin (BN)-based (18)F-labeled peptide synthesized by Mu et al. Histidine 69-72 gastrin releasing peptide Homo sapiens 202-210 14120-15 1976 On the other hand, alkylation of histidine-40 was slowed down most in the presence of 3"-GMP. Histidine 33-42 5'-nucleotidase, cytosolic II Homo sapiens 89-92 511-0 1975 A study of the histidine residues of human carbonic anhydrase C using 270 MHz proton magnetic resonance. Histidine 15-24 carbonic anhydrase 2 Homo sapiens 43-63 1014-0 1975 Evidence for histidine as another functional group of delta-aminolevulinic acid dehydratase from beef liver. Histidine 13-22 aminolevulinate dehydratase Homo sapiens 54-91 238843-8 1975 In the presence of phosphate, titration curves for the H-2 proton resonances of histidine-12 and histidine-119 of methylated RNase-A indicate binding of phosphate at the active site, but these curves continue to show deviations from the titration behaviour of native RNase-A. Histidine 97-106 relaxin 2 Homo sapiens 55-58 1140885-3 1975 These peptides prepared by the stepwise procedure, are: Boc-Phe-Lys(Z)-Gln-Thr(Bzl)-Ser(Bzl)-Lys(Z)-Phe-OMe and Boc-Asp(OBzl)-Asn-Ser(Bzl)-His(Dnp)-Asn(OBzl)-Asp(OBzl)-Ala-Leu-OBzl. Histidine 139-142 BOC cell adhesion associated, oncogene regulated Homo sapiens 56-59 1140885-3 1975 These peptides prepared by the stepwise procedure, are: Boc-Phe-Lys(Z)-Gln-Thr(Bzl)-Ser(Bzl)-Lys(Z)-Phe-OMe and Boc-Asp(OBzl)-Asn-Ser(Bzl)-His(Dnp)-Asn(OBzl)-Asp(OBzl)-Ala-Leu-OBzl. Histidine 139-142 BOC cell adhesion associated, oncogene regulated Homo sapiens 112-115 5097573-9 1971 In elastin from plaque intima, the following polar amino acids were increased significantly: aspartic acid, threonine, serine, glutamic acid, lysine, histidine, and arginine; whereas, cross-linking amino acids: desmosine, isodesmosine, and lysinonorleucine were decreased significantly. Histidine 150-159 elastin Homo sapiens 3-10 5562834-0 1971 On the probable involvement of a histidine residue in the active site of pancreatic lipase. Histidine 33-42 pancreatic lipase Homo sapiens 73-90 4928005-6 1971 (iv) The pathway by which exogenous adenine is converted to guanine nucleotides in the presence of histidine requires a functional purine nucleoside phosphorylase. Histidine 99-108 purine-nucleoside phosphorylase Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 131-162 5778664-0 1969 Evidence for a specific function for histidine residues in transaldolase. Histidine 37-46 transaldolase 1 Homo sapiens 59-72 33682303-2 2021 The product of THG1L is the tRNA-histidine guanylyltransferase 1-like enzyme that catalyzes the 3"-5"addition of guanine to the 5"-end of tRNA-histidine in the mitochondrion. Histidine 33-42 tRNA-histidine guanylyltransferase 1 like Homo sapiens 15-20 33682303-2 2021 The product of THG1L is the tRNA-histidine guanylyltransferase 1-like enzyme that catalyzes the 3"-5"addition of guanine to the 5"-end of tRNA-histidine in the mitochondrion. Histidine 143-152 tRNA-histidine guanylyltransferase 1 like Homo sapiens 15-20 33922150-2 2021 Here, we investigate the effects of the pH solution on MP1 (IDWKKLLDAAKQIL-NH2) adsorption to anionic (7POPC:3POPG) lipid vesicles in comparison to its analog H-MP1, with histidines substituting lysines. Histidine 171-181 pitrilysin metallopeptidase 1 Homo sapiens 55-58 33529484-4 2021 Molecular docking and molecular dynamics simulations suggest that interactions with Glu 39, Glu 78, Arg 111, Pro 137, Asp 251 and His 252 are an important factor for inhibitors affinity toward the DNase I. Histidine 130-133 deoxyribonuclease 1 Homo sapiens 197-204 21709760-0 2011 Locostatin Disrupts Association of Raf Kinase Inhibitor Protein With Binding Proteins by Modifying a Conserved Histidine Residue in the Ligand-Binding Pocket. Histidine 111-120 phosphatidylethanolamine binding protein 1 Homo sapiens 35-63 21673902-2 2011 More than one third of the PLA(2) enzymes belong to the secreted PLA(2) (sPLA(2)) family, which consists of low-molecular-weight, Ca(2+)-requiring extracellular enzymes, with a His-Asp catalytic dyad. Histidine 177-180 phospholipase A2, group IIA (platelets, synovial fluid) Mus musculus 27-32 21673902-2 2011 More than one third of the PLA(2) enzymes belong to the secreted PLA(2) (sPLA(2)) family, which consists of low-molecular-weight, Ca(2+)-requiring extracellular enzymes, with a His-Asp catalytic dyad. Histidine 177-180 phospholipase A2, group IIA (platelets, synovial fluid) Mus musculus 27-33 21673902-2 2011 More than one third of the PLA(2) enzymes belong to the secreted PLA(2) (sPLA(2)) family, which consists of low-molecular-weight, Ca(2+)-requiring extracellular enzymes, with a His-Asp catalytic dyad. Histidine 177-180 phospholipase A2, group IIA (platelets, synovial fluid) Mus musculus 73-80 21059758-3 2011 Using site-directed mutagenesis and metal chelators such as diethylenetriamine pentaacetic acid and deferoxamine, we reveal that a unique histidine at position 191 of CaV3.2 participates in a critical metal binding site, which may in turn interact with N2O to produce reactive oxygen species (ROS). Histidine 138-147 calcium channel, voltage-dependent, T type, alpha 1H subunit Mus musculus 167-173 21138690-7 2010 The enzymatic activity of purified His-tag ALT2 is over 10 000 U/L. Histidine 35-38 glutamic--pyruvic transaminase 2 Homo sapiens 43-47 21081096-3 2010 However, subtle residue motions can be distinguished, specifically of His(329) and Asp(330) to assemble in pol mu"s active site, and of Gln(440) and Glu(443) to help accommodate the incoming nucleotide. Histidine 70-73 DNA polymerase mu Homo sapiens 107-113 20835484-1 2010 Pb-binding TAR-1 peptides (Ile-Ser-Leu-Leu-His-Ser-Thr) were covalently conjugated on a bolaamphiphile peptide nanotube substrate and the precursors of PbSe were incubated at room temperature. Histidine 43-46 trace amine associated receptor 1 Homo sapiens 11-16 21055628-13 2010 CONCLUSION: [(99m)Tc]-(CO)(3) His-annexin A5 may be a useful novel radioligand for the in vivo detection of cell death associated with PS expression. Histidine 30-33 annexin A5 Mus musculus 34-44 21048924-8 2010 RESULTS: The ADH1B*47Arg allele was found to be associated to increased risk of ESCC, with the odds ratios (OR) being 1.62 (95% CI: 1.49-1.76) and 3.86 (2.96-5.03) for the His/Arg and the Arg/Arg genotypes, respectively. Histidine 172-175 alcohol dehydrogenase 1B (class I), beta polypeptide Homo sapiens 13-18 20837014-3 2010 The phospholipase active site possesses a structurally conserved Cys-His-His catalytic triad as found in NlpC/P60 peptidases, indicating H-REV107 should adopt a similar catalytic mechanism towards phospholipid substrates to that of NlpC/P60 peptidases towards peptides. Histidine 69-72 phospholipase A and acyltransferase 3 Homo sapiens 137-145 20837014-3 2010 The phospholipase active site possesses a structurally conserved Cys-His-His catalytic triad as found in NlpC/P60 peptidases, indicating H-REV107 should adopt a similar catalytic mechanism towards phospholipid substrates to that of NlpC/P60 peptidases towards peptides. Histidine 73-76 phospholipase A and acyltransferase 3 Homo sapiens 137-145 20682345-5 2010 The addition of GST, Trx or GB1 to the N-terminal His(6) tag significantly improved both the expression and solubility of target proteins as compared to His(6) tag alone. Histidine 50-53 gamma-aminobutyric acid type B receptor subunit 1 Homo sapiens 28-31 20682345-5 2010 The addition of GST, Trx or GB1 to the N-terminal His(6) tag significantly improved both the expression and solubility of target proteins as compared to His(6) tag alone. Histidine 153-156 gamma-aminobutyric acid type B receptor subunit 1 Homo sapiens 28-31 20660596-5 2010 We have shown previously that this coding change (Y402H; from a tyrosine to histidine residue) alters the binding of the CFH protein to sulfated polysaccharides. Histidine 76-85 complement factor H Homo sapiens 121-124 20690616-3 2010 We have found that a small four-histidine peptide, NAHis04, potently inhibits the Abeta-induced calcium channel currents in artificial lipid membranes. Histidine 32-41 amyloid beta precursor protein Rattus norvegicus 82-87 20690616-9 2010 We have modeled how up to four NAHis04 peptides may block these types of pores by binding to side chains of Abeta residues Glu 11, His 13, and His 14. Histidine 33-36 amyloid beta precursor protein Rattus norvegicus 108-113 20690616-9 2010 We have modeled how up to four NAHis04 peptides may block these types of pores by binding to side chains of Abeta residues Glu 11, His 13, and His 14. Histidine 131-134 amyloid beta precursor protein Rattus norvegicus 108-113 33449614-9 2021 The function of the histidine dyad in the HDAC10 mechanism appears to be similar to that in HDAC6, but not HDAC8 in which both functions are served by the second histidine of the tandem pair. Histidine 20-29 histone deacetylase 10 Homo sapiens 42-48 33449614-9 2021 The function of the histidine dyad in the HDAC10 mechanism appears to be similar to that in HDAC6, but not HDAC8 in which both functions are served by the second histidine of the tandem pair. Histidine 162-171 histone deacetylase 10 Homo sapiens 42-48 33601878-3 2021 In each module, genes with the most connectivity were selected as hub genes, including G antigen 12J (GAGE12J) in blue, proline, histidine and glycine rich 1 (PHGR1) in dark orange, DNA polymerase gamma 2, accessory subunit (POLG2) in dark red and collagen type XXI alpha 1 chain (COL21A1) in dark violet. Histidine 129-138 ELAV like RNA binding protein 2 Homo sapiens 66-69 33197826-0 2021 The N-terminal domain of Helicobacter pylori"s Hpn protein: The role of multiple histidine residues. Histidine 81-90 hepsin Homo sapiens 47-50 33197826-3 2021 Hpn is a protein of 60 amino acids, 47% of which are histidines, expressed by H. pylori and avid for nickel, characterized by the presence of an ATCUN (Amino Terminal Cu(II)- and Ni(II)-binding) motif and by two further histidine residues which can act as additional metal anchoring sites. Histidine 53-63 hepsin Homo sapiens 0-3 33197826-3 2021 Hpn is a protein of 60 amino acids, 47% of which are histidines, expressed by H. pylori and avid for nickel, characterized by the presence of an ATCUN (Amino Terminal Cu(II)- and Ni(II)-binding) motif and by two further histidine residues which can act as additional metal anchoring sites. Histidine 53-62 hepsin Homo sapiens 0-3 33226214-3 2020 Previously, we found that the Sec-devoid His-rich motif of selenoprotein P (Selenop-H) suppressed metal-induced aggregation and neurotoxicities of both Abeta and tau in vitro. Histidine 41-44 selenoprotein P Mus musculus 59-74 32180482-0 2020 Histidine residues at the copper-binding site in human tyrosinase are essential for its catalytic activities. Histidine 0-9 tyrosinase Homo sapiens 55-65 20664961-2 2010 It has also been linked with the change of leucine (L) to histidine (H) or arginine (R) at amino acid position 48 (FcgammaRIIIa-48L/R/H) in the CD16a receptor. Histidine 58-67 Fc gamma receptor IIIa Homo sapiens 115-127 20664961-2 2010 It has also been linked with the change of leucine (L) to histidine (H) or arginine (R) at amino acid position 48 (FcgammaRIIIa-48L/R/H) in the CD16a receptor. Histidine 58-67 Fc gamma receptor IIIa Homo sapiens 144-149 20538074-4 2010 On the other hand, recent whole-heart epicardial and endocardial optical mapping data demonstrate that ventricular arrhythmias in the RyR2(R4496C) mouse model of catecholaminergic polymorphic ventricular tachycardia (CPVT) originate in the His-Purkinje system, suggesting that Purkinje cells, and not ventricular myocytes, may be the cellular source of arrhythmogenic activity. Histidine 240-243 ryanodine receptor 2, cardiac Mus musculus 134-138 20538074-11 2010 CONCLUSION: These results demonstrate that focally activated arrhythmias originate in the specialized electrical conducting cells of the His-Purkinje system in the RyR2(R4496C) mouse model of CPVT. Histidine 137-140 ryanodine receptor 2, cardiac Mus musculus 164-168 20484158-9 2010 In addition, we find that His(132), Val(134), and Asn(141) in human ssTnI, previously identified as enabling contractile function during cellular acidosis, are present in all vertebrate cTnI isoforms except those from monotremes, marsupials, and eutherian mammals. Histidine 26-29 troponin I3, cardiac type Homo sapiens 186-190 20568807-10 2010 On the other hand, quantum mechanical calculations at the DFT/B3LYP/6-31++G* allowed us to analyze the energetic, geometrical, and vibrational features of histidine. Histidine 155-164 protein tyrosine phosphatase non-receptor type 22 Homo sapiens 64-67 20423961-6 2010 This study provides evidence that a His to Ala substitution within mammalian cardiac TnI (cTnI) reduced the thermodynamic potential at the interface between cTnI and cardiac TnC (cTnC) in the calcium-saturated state by disrupting a strong intermolecular electrostatic interaction. Histidine 36-39 troponin I3, cardiac type Homo sapiens 77-88 20423961-6 2010 This study provides evidence that a His to Ala substitution within mammalian cardiac TnI (cTnI) reduced the thermodynamic potential at the interface between cTnI and cardiac TnC (cTnC) in the calcium-saturated state by disrupting a strong intermolecular electrostatic interaction. Histidine 36-39 troponin I3, cardiac type Homo sapiens 90-94 20423961-6 2010 This study provides evidence that a His to Ala substitution within mammalian cardiac TnI (cTnI) reduced the thermodynamic potential at the interface between cTnI and cardiac TnC (cTnC) in the calcium-saturated state by disrupting a strong intermolecular electrostatic interaction. Histidine 36-39 troponin I3, cardiac type Homo sapiens 157-161 20423961-6 2010 This study provides evidence that a His to Ala substitution within mammalian cardiac TnI (cTnI) reduced the thermodynamic potential at the interface between cTnI and cardiac TnC (cTnC) in the calcium-saturated state by disrupting a strong intermolecular electrostatic interaction. Histidine 36-39 tenascin C Homo sapiens 174-177 20332014-10 2010 GENERAL SIGNIFICANCE: These results indicate that an Escherichiacoli-derived full-length His(8)-tagged human MUC17 CRD1-L-CRD2 recombinant protein is a biologically active candidate for further development as a therapeutic agent. Histidine 89-92 mucin 17, cell surface associated Homo sapiens 109-114 33090265-11 2020 Furthermore, positive correlations were observed when comparing plasma DAO activity with histidine, proline, cystine, arginine, and glutamine concentrations. Histidine 89-98 D-amino acid oxidase Bos taurus 71-74 20692404-11 2010 CONCLUSION: Three new enzymes (MTF, NB1, and CI) may enable us to obtain higher islet yields than with HI. Histidine 103-105 metallothionein 1L, pseudogene Homo sapiens 31-34 20451500-7 2010 Each conserved zinc-finger motif of ZAP coordinates a zinc ion using three cysteines and one histidine. Histidine 93-102 zinc finger CCCH-type containing, antiviral 1 Homo sapiens 36-39 20436286-4 2010 Mutation of conserved motif C cysteines and histidines disrupted the association of Dbf4 with ARS1 origin DNA and Mcm2, but not other known ligands including Cdc7, Rad53 or the origin recognition complex subunit Orc2. Histidine 44-54 protein serine/threonine kinase activating protein DBF4 Saccharomyces cerevisiae S288C 84-88 20353168-9 2010 YC-1 binding also strains the Fe-histidine bond, leading to a population of the five-coordinate sGC-CO complex in addition to a conformationally distinct population of the six-coordinate sGC-CO complex. Histidine 33-42 RNA binding motif single stranded interacting protein 1 Homo sapiens 0-4 19697087-6 2010 Treatment of undeveloped ovarian explant cultures with recombinant histidine (His)-RPL10a stimulated the expression of translationally controlled tumor protein (TCTP), heat shock protein 70 (HSP70), and shrimp ovarian peritrophin (SOP) genes, previously shown to be involved in ovarian maturation. Histidine 67-76 heat shock protein family A (Hsp70) member 4 Homo sapiens 168-189 19697087-6 2010 Treatment of undeveloped ovarian explant cultures with recombinant histidine (His)-RPL10a stimulated the expression of translationally controlled tumor protein (TCTP), heat shock protein 70 (HSP70), and shrimp ovarian peritrophin (SOP) genes, previously shown to be involved in ovarian maturation. Histidine 67-76 heat shock protein family A (Hsp70) member 4 Homo sapiens 191-196 19697087-6 2010 Treatment of undeveloped ovarian explant cultures with recombinant histidine (His)-RPL10a stimulated the expression of translationally controlled tumor protein (TCTP), heat shock protein 70 (HSP70), and shrimp ovarian peritrophin (SOP) genes, previously shown to be involved in ovarian maturation. Histidine 78-81 heat shock protein family A (Hsp70) member 4 Homo sapiens 168-189 19697087-6 2010 Treatment of undeveloped ovarian explant cultures with recombinant histidine (His)-RPL10a stimulated the expression of translationally controlled tumor protein (TCTP), heat shock protein 70 (HSP70), and shrimp ovarian peritrophin (SOP) genes, previously shown to be involved in ovarian maturation. Histidine 78-81 heat shock protein family A (Hsp70) member 4 Homo sapiens 191-196 20023146-0 2010 The missing link in plant histidine biosynthesis: Arabidopsis myoinositol monophosphatase-like2 encodes a functional histidinol-phosphate phosphatase. Histidine 26-35 inositol monophosphatase family protein Arabidopsis thaliana 62-95 20023146-8 2010 Our data demonstrate that IMPL2 is the HISN7 gene product, and suggest a lack of genetic redundancy at this metabolic step in Arabidopsis, which is characteristic of the His biosynthetic pathway. Histidine 170-173 inositol monophosphatase family protein Arabidopsis thaliana 26-31 19793597-8 2010 The other was a novel missense mutation resulting in a substitution of Asn (AAC) for His (CAC) at codon 373 in exon 6 (H373N) on a paternal allele. Histidine 85-88 glycine-N-acyltransferase Homo sapiens 76-79 20118557-7 2010 AutoDocking results showed that timolol binds at the entrance of the active site cavity in a region where the proton shuttle residue, His 64, of HCA I or II, is placed. Histidine 134-137 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 145-156 32576658-5 2020 The catalytic domain displayed a polypeptide fold similar overall to those of other members in the DNA cross-link repair gene SNM1 family and in mRNA 3"-end-processing endonuclease CPSF-73, containing metallo-beta-lactamase and beta-CASP domains and a cluster of conserved histidine and aspartate residues capable of binding two metal atoms in the catalytic site. Histidine 273-282 cleavage and polyadenylation specificity factor 3 Mus musculus 145-188 32664451-1 2020 Carnosinase 1 (CN1) is encoded by the Cndp1 gene and degrades carnosine and anserine, two natural histidine-containing dipeptides. Histidine 98-107 carnosine dipeptidase 1 (metallopeptidase M20 family) Mus musculus 0-13 32664451-1 2020 Carnosinase 1 (CN1) is encoded by the Cndp1 gene and degrades carnosine and anserine, two natural histidine-containing dipeptides. Histidine 98-107 carnosine dipeptidase 1 (metallopeptidase M20 family) Mus musculus 15-18 32664451-1 2020 Carnosinase 1 (CN1) is encoded by the Cndp1 gene and degrades carnosine and anserine, two natural histidine-containing dipeptides. Histidine 98-107 carnosine dipeptidase 1 (metallopeptidase M20 family) Mus musculus 38-43 32432920-6 2020 Trachealis smooth muscle tissues were stimulated with recombinant His-S100A4 and the effects on inflammatory responses were evaluated. Histidine 66-69 S100 calcium binding protein A4 Homo sapiens 70-76 19801650-4 2009 The MK structure-function results demonstrate that the His-305, Leu-404, Leu-414, and Val-418 mutations, which increase the free volume of the hVDR ligand binding pocket, significantly enhance MK antagonist potency. Histidine 55-58 vitamin D receptor Homo sapiens 143-147 19954242-2 2009 Among them, the nonsymbiotic hemoglobin AHb1 from Arabidopsis thaliana deserves particular attention, as it combines an extremely high oxygen affinity with an internal hexacoordination of the distal histidine HisE7 to the heme iron in the absence of exogenous ligands. Histidine 199-208 hemoglobin 1 Arabidopsis thaliana 40-44 19946898-8 2009 Furthermore, using a combined approach based on SDS-PAGE, MALDI-TOF and HPLC-ESI-IT mass spectrometry, we were able to identify one main MMP-9 cleavage site that is localized between the amino acids His-715 and Leu-716 of beta-DG, and we analysed the proteolytic fragments of beta-DG(654-750) produced by MMP-9 enzymatic activity. Histidine 199-202 matrix metallopeptidase 9 Homo sapiens 137-142 19778897-5 2009 We found that N-terminal His tags directly influence the interaction between EB1 and MTs, significantly increasing both affinity and activity, and that small amounts of His-tagged proteins act synergistically with larger amounts of untagged proteins. Histidine 25-28 microtubule associated protein RP/EB family member 1 Homo sapiens 77-80 19912621-1 2009 BACKGROUND: Protein kinase C interacting protein (PKCI/HINT1) is a small protein belonging to the histidine triad (HIT) family proteins. Histidine 98-107 protein kinase C, iota Mus musculus 50-54 19912621-1 2009 BACKGROUND: Protein kinase C interacting protein (PKCI/HINT1) is a small protein belonging to the histidine triad (HIT) family proteins. Histidine 98-107 histidine triad nucleotide binding protein 1 Mus musculus 55-60 19661212-6 2009 UGT2B7.1 (His(268)) and UGT2B7.2 (Tyr(268)) enzyme activity was similar, whereas UGT1A3.2 (R(11)A(47)), UGT1A3.3 (Trp(11)), and UGT1A9.3 (Thr(33)) showed 61 to 96% reduced V(max)/K(m) values compared with the respective (1) reference proteins. Histidine 10-13 UDP glucuronosyltransferase family 2 member B7 Homo sapiens 0-6 19735445-0 2009 Cyclo(His-Pro) up-regulates heme oxygenase 1 via activation of Nrf2-ARE signalling. Histidine 6-9 heme oxygenase 1 Rattus norvegicus 28-44 19903770-2 2009 The antiangiogenic properties of HRG are mediated via its proteolytically released histidine- and proline-rich (His/Pro-rich) domain. Histidine 83-92 histidine rich glycoprotein Homo sapiens 33-36 19726676-2 2009 To identify functional partners of ATF4, we applied ROS17/2.8 osteoblast nuclear extracts and purified recombinant His-ATF4 onto a Ni(+) affinity matrix chromatography column. Histidine 115-118 activating transcription factor 4 Homo sapiens 119-123 20641306-4 2004 GRP and BN share an identical C-terminal region (-Trp-Ala-Val-Gly-His-Leu-Met-NH2), which is necessary for receptor binding and signal transduction (5, 6). Histidine 66-69 gastrin releasing peptide Homo sapiens 0-3 19826048-8 2009 The histidine allele at codon 48 of ADH1B gene was associated with a significantly decreased risk of ESCC in the joint data set (primary and validation set) under a recessive model (odds ratio, 0.41; 95% confidence interval, 0.29-0.76; P = 4 x 10(-4)). Histidine 4-13 alcohol dehydrogenase 1B (class I), beta polypeptide Homo sapiens 36-41 19666115-2 2009 As a strategy to identify TIMP-3 binding proteins, we used tandem affinity purification, employing recombinant adenoviruses constructed to deliver TIMP-3 fused to C-terminal S and His tags (TIMP-3-S-His) or TIMP-1-S-His control to endothelial cells prior to extraction. Histidine 199-202 TIMP metallopeptidase inhibitor 3 Homo sapiens 26-32 19666115-2 2009 As a strategy to identify TIMP-3 binding proteins, we used tandem affinity purification, employing recombinant adenoviruses constructed to deliver TIMP-3 fused to C-terminal S and His tags (TIMP-3-S-His) or TIMP-1-S-His control to endothelial cells prior to extraction. Histidine 199-202 TIMP metallopeptidase inhibitor 3 Homo sapiens 26-32 19666192-1 2009 The tripeptide thyrotropin-releasing hormone (TRH, pGlu-His-Pro-NH2) has been shown to possess neuroprotective activity in in vitro and in vivo models. Histidine 56-59 thyrotropin releasing hormone Mus musculus 15-44 19666192-1 2009 The tripeptide thyrotropin-releasing hormone (TRH, pGlu-His-Pro-NH2) has been shown to possess neuroprotective activity in in vitro and in vivo models. Histidine 56-59 thyrotropin releasing hormone Mus musculus 46-49 19735146-6 2009 We show that the peptide charge, and more precisely the protonation state of histidines 13 and/or 14, is important for the interaction with lipids. Histidine 77-87 olfactory receptor family 10 subfamily K member 2 Homo sapiens 95-100 32333447-1 2020 Mutations in histidyl-tRNA synthetase (HARS1), an enzyme that charges tRNA with the amino acid histidine in the cytoplasm, have only been associated to date with autosomal recessive Usher syndrome type III and autosomal dominant Charcot-Marie-Tooth disease type 2W. Histidine 95-104 histidyl-tRNA synthetase 1 Homo sapiens 13-37 19500832-2 2009 Alpha-elastin was chemically crosslinked with hexamethylene diisocyanate that can react with various functional groups in elastin such as lysine, cysteine, and histidine. Histidine 160-169 elastin Homo sapiens 6-13 19500832-2 2009 Alpha-elastin was chemically crosslinked with hexamethylene diisocyanate that can react with various functional groups in elastin such as lysine, cysteine, and histidine. Histidine 160-169 elastin Homo sapiens 122-129 19809679-5 2009 Coordination of Asp 1 to Zn drives the complex towards the expulsion of one of initially bonded His side-chains. Histidine 96-99 beta-secretase 2 Homo sapiens 16-21 19406162-5 2009 In this study, one recombinant baculovirus BacSC-NS3 expressing histidine-tagged NS3 with the transmembrane domain (TM) and cytoplasmic domain (CTD) derived from baculovirus envelope protein gp64 of baculovirus was constructed. Histidine 64-73 KRAS proto-oncogene, GTPase Homo sapiens 49-52 19406162-5 2009 In this study, one recombinant baculovirus BacSC-NS3 expressing histidine-tagged NS3 with the transmembrane domain (TM) and cytoplasmic domain (CTD) derived from baculovirus envelope protein gp64 of baculovirus was constructed. Histidine 64-73 KRAS proto-oncogene, GTPase Homo sapiens 81-84 19515935-5 2009 Although the histidine-tagged CTD (hCTD) was monomeric in solution, hCTD bound cooperatively to three of the recombination substrates (attB, attL and attR). Histidine 13-22 transthyretin Homo sapiens 150-154 19396588-0 2009 One-step column purification of herpes simplex virus 1 helicase-primase subcomplex using C-terminally his-tagged UL5 subunit. Histidine 102-105 helicase-primase helicase subunit Human alphaherpesvirus 1 113-116 19396588-2 2009 In order to bind the enzyme complex consisting of UL5 and UL52 gene functions to the affinity column, the C-terminus of the UL5 gene of HSV-1 strain ANG was fused in-frame with a sequence encoding six histidines, resulting in a His6-tagged DNA helicase (UL5his) when expressed via recombinant baculovirus. Histidine 201-211 helicase-primase helicase subunit Human alphaherpesvirus 1 50-53 19396588-2 2009 In order to bind the enzyme complex consisting of UL5 and UL52 gene functions to the affinity column, the C-terminus of the UL5 gene of HSV-1 strain ANG was fused in-frame with a sequence encoding six histidines, resulting in a His6-tagged DNA helicase (UL5his) when expressed via recombinant baculovirus. Histidine 201-211 helicase-primase helicase subunit Human alphaherpesvirus 1 58-61 18817875-10 2009 The result of mass spectrometry confirmed that the purified His-tagged DmUCH can recognize the ubiquitin-magainin fusion protein and cleave it at the carboxyl terminus of ubiquitin precisely. Histidine 60-63 Ribosomal protein L40 Drosophila melanogaster 95-104 18817875-10 2009 The result of mass spectrometry confirmed that the purified His-tagged DmUCH can recognize the ubiquitin-magainin fusion protein and cleave it at the carboxyl terminus of ubiquitin precisely. Histidine 60-63 Ribosomal protein L40 Drosophila melanogaster 171-180 32145391-7 2020 We compared cAMP response induced by histidine tagged CCL7 and native CCL7 and found that modification of the N-terminus of CCL7 compromises its functionality. Histidine 37-46 C-C motif chemokine ligand 7 Homo sapiens 54-58 32265297-10 2020 Interestingly, in OTUB2, the catalytic residues His-224 and Asn-226 formed a stable hydrogen bond. Histidine 48-51 OTU deubiquitinase, ubiquitin aldehyde binding 2 Homo sapiens 18-23 31827252-1 2020 HARS2 encodes mitochondrial histidyl-tRNA synthetase (HARS2), which links histidine to its cognate tRNA in the mitochondrial matrix. Histidine 74-83 histidyl-tRNA synthetase 2, mitochondrial Homo sapiens 0-5 31827252-1 2020 HARS2 encodes mitochondrial histidyl-tRNA synthetase (HARS2), which links histidine to its cognate tRNA in the mitochondrial matrix. Histidine 74-83 histidyl-tRNA synthetase 1 Homo sapiens 28-52 31827252-1 2020 HARS2 encodes mitochondrial histidyl-tRNA synthetase (HARS2), which links histidine to its cognate tRNA in the mitochondrial matrix. Histidine 74-83 histidyl-tRNA synthetase 2, mitochondrial Homo sapiens 54-59 31957446-0 2020 Expression and Purification of Protease-Activated Receptor 4 (PAR4) and Analysis with Histidine Hydrogen-Deuterium Exchange. Histidine 86-95 F2R like thrombin or trypsin receptor 3 Homo sapiens 31-60 31957446-7 2020 PAR4 has nine histidines that are spaced throughout the protein, allowing a global view of solvent accessible and nonaccessible regions. Histidine 14-24 F2R like thrombin or trypsin receptor 3 Homo sapiens 0-4 31957446-9 2020 The thrombin-cleaved PAR4 exhibited a 2-fold increase (p > 0.01) in t1/2 values observed for four histidine residues (His180, His229, His240, and His380), demonstrating that these regions have decreased solvent accessibility upon thrombin treatment. Histidine 98-107 F2R like thrombin or trypsin receptor 3 Homo sapiens 21-25 31722196-6 2019 Metabolic profiling of fly heads revealed that loss of dMyc and its overexpression alter steady-state metabolite levels and have opposing effects on histidine, the histamine precursor, which is rescued in dMyc mutants by ablation of dMnt and could contribute to effects of dMyc on locomotor behavior. Histidine 149-158 Myc Drosophila melanogaster 55-59 31722196-6 2019 Metabolic profiling of fly heads revealed that loss of dMyc and its overexpression alter steady-state metabolite levels and have opposing effects on histidine, the histamine precursor, which is rescued in dMyc mutants by ablation of dMnt and could contribute to effects of dMyc on locomotor behavior. Histidine 149-158 Myc Drosophila melanogaster 205-209 31722196-6 2019 Metabolic profiling of fly heads revealed that loss of dMyc and its overexpression alter steady-state metabolite levels and have opposing effects on histidine, the histamine precursor, which is rescued in dMyc mutants by ablation of dMnt and could contribute to effects of dMyc on locomotor behavior. Histidine 149-158 Myc Drosophila melanogaster 205-209 31502464-5 2019 Modified forms of SUMO1 or SUMO2, with a histidine tag and a Thr to Lys mutation preceding the carboxyl-terminal di-gly motif, were expressed in mpkCCD14 cells, allowing SUMO-conjugated proteins to be purified and identified. Histidine 41-50 small ubiquitin like modifier 2 Homo sapiens 27-32 31220406-3 2019 Histidine-rich nona-arginine (HR9) and primary amphipathic peptide (MPG) showed the ability to transfer DNA into the cells. Histidine 0-9 N-methylpurine DNA glycosylase Homo sapiens 68-71 19504439-5 2009 RESULTS: Alignment of the GATA-4 amino acid sequence indicated that the histidine residue at position 436 was conserved, and H436Y mutation in the GATA-4 gene is expected to affect its protein function. Histidine 72-81 GATA binding protein 4 Homo sapiens 26-32 19246456-5 2009 Substitution of the three polar amino acid residues (His(46), Gln(50), and Gln(53)) within this motif with alanine abolishes the inhibitory effect of Angptl4 on LPL in vitro and also abrogates the ability of Angptl4 to elevate plasma triglyceride levels in mice. Histidine 53-56 lipoprotein lipase Mus musculus 161-164 31315927-5 2019 Purified recombinant GST-TIMAP interacted directly with purified recombinant His-MLC2. Histidine 77-80 protein phosphatase 1, regulatory subunit 16B Mus musculus 25-30 31327794-3 2019 We evaluated the success rate of LBP/peri-LBP in patients whose treatment with His-bundle pacing failed. Histidine 79-82 lipopolysaccharide binding protein Homo sapiens 33-36 31327794-3 2019 We evaluated the success rate of LBP/peri-LBP in patients whose treatment with His-bundle pacing failed. Histidine 79-82 perilipin 1 Homo sapiens 37-41 31327794-5 2019 CONCLUSIONS: LBP/peri-LBP is an alternative ventricular pacing method in atrioventricular block in patients with failure of His-bundle pacing. Histidine 124-127 lipopolysaccharide binding protein Homo sapiens 13-16 31327794-5 2019 CONCLUSIONS: LBP/peri-LBP is an alternative ventricular pacing method in atrioventricular block in patients with failure of His-bundle pacing. Histidine 124-127 perilipin 1 Homo sapiens 17-21 31327794-5 2019 CONCLUSIONS: LBP/peri-LBP is an alternative ventricular pacing method in atrioventricular block in patients with failure of His-bundle pacing. Histidine 124-127 lipopolysaccharide binding protein Homo sapiens 22-25 31273433-2 2019 Very low islet zinc levels in Guinea pigs were thought to be driven by evolution of the INS gene that resulted in the generation of an isoform lacking a histidine at amino acid 10 in the B chain of insulin that is unable to bind zinc. Histidine 153-162 insulin Cavia porcellus 198-205 19191736-7 2009 Those residues responsible for anchoring the hexose moieties of the dTDP-sugars to the protein include Glu 141, Asn 159, and Asp 160 from one subunit and His 134 from another subunit. Histidine 154-157 TAR DNA-binding protein-43 homolog Drosophila melanogaster 68-72 19199251-5 2009 RESULTS: A missense mutation of GAT>CAT was identified at codon 1441 of the COL1A1 gene from the family, which resulted in the replacement of aspartic acid by histidine (D1441H). Histidine 159-168 collagen type I alpha 1 chain Homo sapiens 76-82 31164399-8 2019 This work helps to establish the structure/function relationship of ZIP4 and also sheds light on other metal transporters and metalloproteins with clustered histidine residues. Histidine 157-166 solute carrier family 39 member 4 Homo sapiens 68-72 30317586-0 2019 A pH-sensitive luminal His-cluster promotes interaction of PAM with V-ATPase along the secretory and endocytic pathways of peptidergic cells. Histidine 23-26 peptidylglycine alpha-amidating monooxygenase Homo sapiens 59-62 19107418-3 2009 Two alternative procedures are described for the E1 enzyme, one depending on co-expression of His-Aos1 and untagged Uba2, and a second protocol for separate expression of His-Aos1 and Uba2-His and subsequent reconstitution of the active dimer. Histidine 94-97 SUMO1 activating enzyme subunit 1 Homo sapiens 98-102 19107418-3 2009 Two alternative procedures are described for the E1 enzyme, one depending on co-expression of His-Aos1 and untagged Uba2, and a second protocol for separate expression of His-Aos1 and Uba2-His and subsequent reconstitution of the active dimer. Histidine 171-174 SUMO1 activating enzyme subunit 1 Homo sapiens 175-179 19107418-3 2009 Two alternative procedures are described for the E1 enzyme, one depending on co-expression of His-Aos1 and untagged Uba2, and a second protocol for separate expression of His-Aos1 and Uba2-His and subsequent reconstitution of the active dimer. Histidine 171-174 SUMO1 activating enzyme subunit 1 Homo sapiens 175-179 30826412-8 2019 Furthermore, based on the in vivo neutralization assay, recombinant His-beta-actin accelerated the infection of WSSV, conversely, recombinant His-Rab7 delayed WSSV infection in shrimp. Histidine 68-71 POTE ankyrin domain family member F Homo sapiens 72-82 30819802-4 2019 The dehydrin Lti30 (Arabidopsis thaliana) is up-regulated during cold and drought stress conditions and comprises six K-segments, each with two adjacent histidines. Histidine 153-163 dehydrin family protein Arabidopsis thaliana 13-18 30819802-5 2019 Lti30 interacts with the membrane electrostatically via pH-dependent protonation of the histidines. Histidine 88-98 dehydrin family protein Arabidopsis thaliana 0-5 30804004-0 2019 Histidine is selectively required for the growth of Myc-dependent dedifferentiation tumours in the Drosophila CNS. Histidine 0-9 Myc Drosophila melanogaster 52-55 30804004-4 2019 The reliance of tumours on dietary histidine and also on histidine decarboxylase (Hdc) depends upon their growth requirement for Myc. Histidine 35-44 Myc Drosophila melanogaster 129-132 30804004-5 2019 We demonstrate that Myc overexpression in nerfin-1 tumours is sufficient to switch their mode of growth from histidine/Hdc sensitive to resistant. Histidine 109-118 Myc Drosophila melanogaster 20-23 30701963-6 2019 Ab-MB served as a sensing probe for the competitive immunorecognitions between known concentrations of His-tag RGS11 and unknown concentrations of target RGS11 in serum. Histidine 103-106 regulator of G protein signaling 11 Homo sapiens 111-116 30593504-0 2019 An extracellular histidine-containing motif in the zinc transporter ZIP4 plays a role in zinc sensing and zinc-induced endocytosis in mammalian cells. Histidine 17-26 solute carrier family 39 member 4 Homo sapiens 68-72 30593504-5 2019 In this study, we used mutational analysis, immunoblotting, HEK293 cells, and immunofluorescence microscopy to identify a histidine-containing motif (398HTH) in the first extracellular loop that is required for high sensitivity to low zinc concentrations in a zinc-induced endocytic response of mouse ZIP4 (mZIP4). Histidine 122-131 solute carrier family 39 (zinc transporter), member 4 Mus musculus 301-305 30593504-5 2019 In this study, we used mutational analysis, immunoblotting, HEK293 cells, and immunofluorescence microscopy to identify a histidine-containing motif (398HTH) in the first extracellular loop that is required for high sensitivity to low zinc concentrations in a zinc-induced endocytic response of mouse ZIP4 (mZIP4). Histidine 122-131 solute carrier family 39 (zinc transporter), member 4 Mus musculus 307-312 30593504-6 2019 Moreover, using synthetic peptides with selective substitutions and truncated mZIP4 variants, we provide evidence that histidine residues in this motif coordinate a zinc ion in mZIP4 homodimers at the plasma membrane. Histidine 119-128 solute carrier family 39 (zinc transporter), member 4 Mus musculus 78-83 30593504-6 2019 Moreover, using synthetic peptides with selective substitutions and truncated mZIP4 variants, we provide evidence that histidine residues in this motif coordinate a zinc ion in mZIP4 homodimers at the plasma membrane. Histidine 119-128 solute carrier family 39 (zinc transporter), member 4 Mus musculus 177-182 30785395-5 2019 In conclusion, this study is the first to show a catalytic mechanism of SETD3-mediated histidine methylation on beta-actin, which not only throws light on the protein histidine methylation phenomenon but also facilitates the design of small molecule inhibitors of SETD3. Histidine 87-96 POTE ankyrin domain family member F Homo sapiens 112-122 30785395-5 2019 In conclusion, this study is the first to show a catalytic mechanism of SETD3-mediated histidine methylation on beta-actin, which not only throws light on the protein histidine methylation phenomenon but also facilitates the design of small molecule inhibitors of SETD3. Histidine 167-176 POTE ankyrin domain family member F Homo sapiens 112-122 30455352-1 2019 Hsp70 chaperones are central hubs of the protein quality control network and collaborate with co-chaperones having a J-domain (an ~70-residue-long helical hairpin with a flexible loop and a conserved His-Pro-Asp motif required for ATP hydrolysis by Hsp70s) and also with nucleotide exchange factors to facilitate many protein-folding processes that (re)establish protein homeostasis. Histidine 200-203 heat shock protein family A (Hsp70) member 4 Homo sapiens 0-5 30535142-4 2019 Using CRISPR knockout, we show that CRHR1 is necessary for acid-induced POMC expression, and this induction is mediated by CRHR1 histidine residues and calmodulin-dependent protein kinase II in both pituitary corticotroph cells and in nonpituitary cell lines expressing ectopic ACTH. Histidine 129-138 corticotropin releasing hormone receptor 1 Mus musculus 123-128 30728809-4 2019 Using molecular dynamics simulations, we demonstrate that ABBA binds to the "central cavity" in the elbow of vWbp by interacting with Arg-70, His-71, Ala-72, Gly-73, Tyr-74, Glu-75, Tyr-83, and Gln-87 in vWbp, thus interfering with the binding of vWbp to prothrombin. Histidine 142-145 MTSS I-BAR domain containing 2 Mus musculus 58-62 31172469-2 2019 Referred to as cytochrome b558, because of its signature spectral absorbance at 558 nm in reduced-minus-oxidized difference spectroscopy, or cytochrome b(-245), because of its very low midpoint potential of -245 mV at pH 7.0, the protein possesses two stacked inequivalent hemes ligated by pairs of histidine residues in membrane helices h3 and h5. Histidine 299-308 mitochondrially encoded cytochrome b Homo sapiens 15-27 29936386-4 2018 Compared with Taxol solution and HA-DOCA micelles, the cytotoxicity of PTX loaded in HA-DOCA-His micelles against drug-resistant tumor cells was improved significantly and possessed superior MDR-overcoming performance; this phenomenon is due to the increased intracellular PTX delivery by CD44 receptor-mediated endocytosis pathway and endosome-pH sensitivity-mediated PTX triggering release. Histidine 93-96 CD44 antigen Mus musculus 289-293 30069489-3 2018 SLC15A3, a proton-coupled histidine and di-tripeptide transporter that was previously found in lysosomes, has been reported to inhibit chikungunya viral replication in host cells. Histidine 26-35 solute carrier family 15 member 3 Homo sapiens 0-7 18852012-15 2008 The first NAT crystallographic structure from Salmonella typhimurium identified the mechanism of acetyl transfer via a catalytic triad of Cys, His and Asp residues each essential for activity in all NATs. Histidine 143-146 bromodomain containing 2 Homo sapiens 10-13 18952607-5 2008 A direct interaction was indicated by in vitro pull-down assay, in which S-His-RASA3 preferentially bound guanosine 5"-O-(gamma-thio)triphosphate-activated Galphai3 and Galphai2 compared with guanosine 5"-O-(beta-thio)diphosphate-inactivated proteins. Histidine 75-78 RAS p21 protein activator 3 Rattus norvegicus 79-84 18848840-8 2008 In the smoking group, there was a 0.15-fold (OR(adj), 0.15; 95% CI, 0.03-0.68; P=0.01) decreased risk of CBP for subjects carrying genotypes of hMYH 324His/Gln+Gln/Gln compared with those of genotype of hMYH 324His/His. Histidine 152-155 mutY DNA glycosylase Homo sapiens 144-148 20641678-1 2004 Both GRP and BBN share an amidated C-terminus sequence homology of 7 amino acids, -Trp-Ala-Val-Gly-His-Leu-Met-NH2. Histidine 99-102 gastrin releasing peptide Homo sapiens 5-8 18829452-7 2008 Here we report on the interactions of RhoA, Rac1, and Cdc42 with mDia1 and an mDia1 mutant (mDia(N)-Thr-Ser-His (TSH)), which based on structural information should mimic mDia2 and -3. Histidine 108-111 Rac family small GTPase 1 Homo sapiens 44-48 18836178-2 2008 APTX is a member of the histidine triad superfamily of nucleotide hydrolases and transferases but is distinct from other family members in that it acts upon DNA. Histidine 24-33 aprataxin Homo sapiens 0-4 18836178-7 2008 These results pinpoint APTX as the first protein to adopt canonical histidine triad-type reaction chemistry for the repair of DNA. Histidine 68-77 aprataxin Homo sapiens 23-27 18808205-0 2008 The effect of histidine residue modification on tyrosinase activity and conformation: inhibition kinetics and computational prediction. Histidine 14-23 tyrosinase Homo sapiens 48-58 18808205-1 2008 We found that the histidine chemical modification of tyrosinase conspicuously inactivated enzyme activity. Histidine 18-27 tyrosinase Homo sapiens 53-63 18808205-7 2008 The computational prediction was informative to elucidate the role of free histidine residues at the active site, which are related to substrate accessibility during tyrosinase catalysis. Histidine 75-84 tyrosinase Homo sapiens 166-176 18761348-8 2008 However, the replacement of histidine at position 294 (H294) and phenylalanine at 129 (F129) affected the ATP-induced conformational change of the DNA-HsRad51 filament, although it did not prevent DNA binding. Histidine 28-37 RAD51 recombinase Homo sapiens 151-158 18790006-3 2008 CN2 (CNDP2) is a cytosolic enzyme that can hydrolyze carnosine to yield l-histidine and beta-alanine. Histidine 72-83 carnosine dipeptidase 2 Homo sapiens 0-3 18790006-3 2008 CN2 (CNDP2) is a cytosolic enzyme that can hydrolyze carnosine to yield l-histidine and beta-alanine. Histidine 72-83 carnosine dipeptidase 2 Homo sapiens 5-10 18790006-8 2008 These results suggest that CN2 is highly expressed in the histaminergic neurons in the tuberomammillary nucleus, implying that it may supply histidine to histaminergic neurons for histamine synthesis. Histidine 141-150 carnosine dipeptidase 2 Homo sapiens 27-30 18656488-1 2008 We have analyzed the role of individual heme-ligating histidine residues for assembly of holo-cytochrome b(6), and we show that the two hemes b(L) and b(H) bind in two subsequent steps to the apo-protein. Histidine 54-63 mitochondrially encoded cytochrome b Homo sapiens 94-106 18664522-12 2008 PCaP1 lacks cysteine and histidine residues. Histidine 25-34 plasma-membrane associated cation-binding protein 1 Arabidopsis thaliana 0-5 18767815-3 2008 In Ngb, the imidazole of a histidine residue (His-64) in the distal position, above the heme plane, provides the sixth coordination bond. Histidine 27-36 neuroglobin Homo sapiens 3-6 18767815-3 2008 In Ngb, the imidazole of a histidine residue (His-64) in the distal position, above the heme plane, provides the sixth coordination bond. Histidine 46-49 neuroglobin Homo sapiens 3-6 18767815-11 2008 Together, the data support the argument that wild-type Ngb is protected from attack by H 2O 2 by the coordinated distal His. Histidine 120-123 neuroglobin Homo sapiens 55-58 18707164-3 2008 The specific residues of MDM2 that have dominant binding interactions with p53 are specifically identified to be (51)Lys, (54)Leu, (62)Met, (67)Tyr, (72)Gln, (94)Lys, (96)His, and (100)Tyr. Histidine 171-174 MDM2 proto-oncogene Homo sapiens 25-29 18480028-3 2008 Because ACAT enzymes have an intrinsic thioesterase activity, we hypothesized that by analogy with the thioesterase domain of fatty acid synthase, the active site of ACAT enzymes may comprise a catalytic triad of ser-his-asp (S-H-D) amino acid residues. Histidine 217-220 fatty acid synthase Homo sapiens 126-145 29659163-2 2018 In this study, the alpha-MSH-derived peptide NAP-NS1 (Nle-Asp-His-d-Phe-Arg-Trp-Gly-NH2 ) with and without linkers was conjugated with 5-(bis(pyridin-2-ylmethyl)amino)pentanoic acid (DPA-COOH) and labeled with [99m Tc]Tc-tricarbonyl by two methods. Histidine 62-65 influenza virus NS1A binding protein Homo sapiens 49-52 29844495-6 2018 Structure comparisons identify a TIRR histidine (H106) that is absent from the TIRR homolog Nudt16, but essential for 53BP1 Tudor binding. Histidine 38-47 nudix hydrolase 16 Homo sapiens 92-98 29744598-8 2018 In contrast, the overall size of interferon-tau was determined by AF4 to decrease in the presence of histidine, which is known to bind to the native state, thereby providing conformational stabilization. Histidine 101-110 AF4/FMR2 family member 1 Homo sapiens 66-69 29744598-9 2018 Addition of histidine as the buffer resulted in formation of fewer subvisible particles over time at 50 C. Finally, the thermal aggregation was monitored using AF4 and the rate constants were found to be comparable to those determined previously by SEC and DLS. Histidine 12-21 AF4/FMR2 family member 1 Homo sapiens 160-163 29463709-4 2018 Biochemical studies showed that the GAS41 YEATS domain presents significant binding affinity toward H3K122suc upon a protonated histidine residue. Histidine 128-137 YEATS domain containing 4 Homo sapiens 36-41 18381743-4 2008 For SF2 chemical ligation made use of the histidine and the cysteine residues located in positions 41 and 42 of the native sequence, respectively, to afford a highly efficient synthesis of SF2 compared to the standard SPPS elongation method. Histidine 42-51 serine and arginine rich splicing factor 1 Homo sapiens 4-7 18381743-4 2008 For SF2 chemical ligation made use of the histidine and the cysteine residues located in positions 41 and 42 of the native sequence, respectively, to afford a highly efficient synthesis of SF2 compared to the standard SPPS elongation method. Histidine 42-51 serine and arginine rich splicing factor 1 Homo sapiens 189-192 18582542-1 2008 Modification of catalytic residue His-47 with p-bromophenacyl bromide (BPB) abolished the enzymatic activity of Naja naja atra phospholipase A2 (PLA2). Histidine 34-37 phospholipase A2 group IIA Homo sapiens 145-149 18627314-1 2008 Azurocidin belongs to the serprocidin family, but it is devoid of proteolytic activity due to a substitution of His and Ser residues in the catalytic triad. Histidine 112-115 azurocidin 1 Homo sapiens 0-10 18627314-6 2008 The first isoleucine present in mature azurocidin can be replaced by similar amino acids, such as leucine or valine, but its substitution by histidine or arginine decreases proteolytic activity. Histidine 141-150 azurocidin 1 Homo sapiens 39-49 18430729-4 2008 The results indicate that binding of the ShB peptide to KcsA involves the ortho and meta protons of Tyr(8), which exhibit the strongest STD effects; the C4H in the imidazole ring of His(16); the methyl protons of Val(4), Leu(7), and Leu(10) and the side chain amine protons of one, if not both, the Lys(18) and Lys(19) residues. Histidine 182-185 SH2 domain containing adaptor protein B Homo sapiens 41-44 18523251-6 2008 The lysine-free HIV-1 Nef mutant (Delta10K) generated by replacing all 10 lysines with arginines was not ubiquitinated and the major ubiquitin-His attachment sites in HIV-1 Nef were determined to be lysine 144 (di-ubiquitinated) and lysine 204 (mono-ubiquitinated). Histidine 143-146 Nef Human immunodeficiency virus 1 22-25 29463709-6 2018 To investigate the binding mechanism, we solved the crystal structure of the YEATS domain of Yaf9, the GAS41 homolog, in complex with an H3K122suc peptide that demonstrated the presence of a salt bridge formed when a protonated histidine residue (His39) recognizes the carboxyl terminal of the succinyl group. Histidine 228-237 YEATS domain containing 4 Homo sapiens 93-97 29463709-6 2018 To investigate the binding mechanism, we solved the crystal structure of the YEATS domain of Yaf9, the GAS41 homolog, in complex with an H3K122suc peptide that demonstrated the presence of a salt bridge formed when a protonated histidine residue (His39) recognizes the carboxyl terminal of the succinyl group. Histidine 228-237 YEATS domain containing 4 Homo sapiens 103-108 29513344-0 2018 Antioxidant activity and inhibitory effects of 2-hydroxy-3-methylcyclopent-2-enone isolated from ribose-histidine Maillard reaction products on aldose reductase and tyrosinase. Histidine 104-113 tyrosinase Homo sapiens 165-175 29513344-3 2018 Among the MRPs, ribose-histidine MRPs (RH-MRPs) showed the highest inhibitory activities on the ABTS+ radical scavenging ability, aldose reductase (AR), and tyrosinase compared to other MRPs. Histidine 23-32 tyrosinase Homo sapiens 157-167 29350903-1 2018 In this work, a typical cylinder-shaped tobacco mosaic virus coat protein (TMVCP) is employed as an anisotropic building block to assemble into triclinic and hexagonal close-packed (HCP) protein crystals by introducing cysteine residues at the 1 and 3 sites and four histidine residues at the C-terminal, respectively. Histidine 267-276 Coat protein Tobacco mosaic virus 61-73 29578158-3 2018 Materials and Methods: In this study, we constructed a eukaryotic expression vector pcDNA3.1D/V5-His-TOPO/Syk and transfected it into human nonsmall cell lung cancer cells A549. Histidine 97-100 spleen associated tyrosine kinase Homo sapiens 106-109 18386080-3 2008 The protein shows unprecedented properties within the cytochrome c (4) family, including (1) an almost nonpolar surface charge distribution, (2) the absence of high-spin heme Fe(III) states, indicative of a thermodynamically stable and kinetically inert axial heme His,Met coordination, and (3) identical E degrees " values for the two heme centers (+0.322 V vs the standard hydrogen elecrode). Histidine 265-268 PSHA_RS13535 Pseudoalteromonas haloplanktis TAC125 54-66 29078150-2 2018 In the human protein (hNgb), Cys46 and Cys55 form an intramolecular disulfide bond under oxidizing conditions, whose cleavage induces a helix-to-strand rearrangement of the CD loop that strengthens the bond between the heme iron and the distal histidine. Histidine 244-253 neuroglobin Homo sapiens 22-26 18280705-1 2008 BACKGROUND: Histidase (histidine ammonia lyase) converts histidine into urocanic acid, the main ultraviolet (UV) light absorption factor of the stratum corneum. Histidine 23-32 histidine ammonia-lyase Homo sapiens 12-21 18263814-1 2008 PURPOSE: A Tyr-to-His (Y402H) sequence variant in the factor H (FH) and factor H-like protein (FHL-1) gene is strongly associated with an increased susceptibility for age-related macular degeneration (AMD). Histidine 18-21 complement factor H Homo sapiens 54-62 18263814-1 2008 PURPOSE: A Tyr-to-His (Y402H) sequence variant in the factor H (FH) and factor H-like protein (FHL-1) gene is strongly associated with an increased susceptibility for age-related macular degeneration (AMD). Histidine 18-21 complement factor H Homo sapiens 72-80 18260012-6 2008 In the selected DNA binding peptides, aromatic amino acids such as histidine for CORE and glutamine/aspartic acid for AP2 were found to be abundant amino acids. Histidine 67-76 transcription factor AP-2 alpha Homo sapiens 118-121 17997327-3 2008 We have been able to isolate milligram quantities of highly purified His(6)-NS1 and NS1-His(6) by nickel affinity chromatography. Histidine 69-72 influenza virus NS1A binding protein Homo sapiens 76-79 17997327-3 2008 We have been able to isolate milligram quantities of highly purified His(6)-NS1 and NS1-His(6) by nickel affinity chromatography. Histidine 88-91 influenza virus NS1A binding protein Homo sapiens 84-87 20641773-2 2004 Both GRP and BN share an amidated C-terminus sequence homology of 7 amino acids, -Trp-Ala-Val-Gly-His-Leu-Met-NH2. Histidine 98-101 gastrin releasing peptide Homo sapiens 5-8 17868038-10 2008 The present study represents the first report on recombinant His-tagged GMPS from parasitic protozoa. Histidine 61-64 guanine monophosphate synthase Homo sapiens 72-76 17523919-2 2008 DRR1 from Homo sapiens was cloned into the pQE30 vector for fusion-protein expression with six histidine residues in Escherichia coli BL21(DE3). Histidine 95-104 family with sequence similarity 107 member A Homo sapiens 0-4 18239414-4 2008 The periplasmic domain of CnrX (residues 29- 148) was cloned as a N-terminal His-tagged protein, expressed in Escherichia coli, and purified using affinity chromatography and gel filtration. Histidine 77-80 periplasmic nickel sensor Cupriavidus metallidurans CH34 26-30 18073526-9 2007 The cytostatic and cytotoxic effects of Amph required its ribonuclease activity: the enzymatically inactive Amph-2 having histidine at the active site alkylated was ineffective. Histidine 122-131 bridging integrator 1 Homo sapiens 108-114 17956868-8 2007 Replacing Pro-40 of UGT1A4 by histidine expanded the glucuronidation activity of the enzyme to phenolic and carboxylic compounds, therefore, leading to UGT1A3-type isoform in terms of substrate specificity. Histidine 30-39 UDP glucuronosyltransferase family 1 member A3 Homo sapiens 152-158 17956868-9 2007 Conversely, when His-40 residue of UGT1A3 was replaced with proline, the substrate specificity shifted toward that of UGT1A4 with loss of glucuronidation of phenolic substrates. Histidine 17-20 UDP glucuronosyltransferase family 1 member A3 Homo sapiens 35-41 17956868-10 2007 Furthermore, mutation of His-39 residue of UGT1A1 (His-40 in UGT1A4) to proline led to loss of glucuronidation of phenols but not of estrogens. Histidine 25-28 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 43-49 17956868-10 2007 Furthermore, mutation of His-39 residue of UGT1A1 (His-40 in UGT1A4) to proline led to loss of glucuronidation of phenols but not of estrogens. Histidine 51-54 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 43-49 17953656-3 2007 Here, we show that replacing histidine in position 105 in the alpha(5) subunit by cysteine strongly stimulates the effect of zolpidem in receptors containing the alpha(5) subunit. Histidine 29-38 immunoglobulin binding protein 1 Homo sapiens 62-67 17953656-3 2007 Here, we show that replacing histidine in position 105 in the alpha(5) subunit by cysteine strongly stimulates the effect of zolpidem in receptors containing the alpha(5) subunit. Histidine 29-38 immunoglobulin binding protein 1 Homo sapiens 162-167 17953656-7 2007 Other studies have shown that replacement of these histidines alpha(1) H101, alpha(2) H101, and alpha(3) H126 by arginine, as naturally present in alpha(4) and alpha(6) , leads to benzodiazepine insensitivity of these receptors. Histidine 51-61 immunoglobulin binding protein 1 Homo sapiens 62-67 17953656-7 2007 Other studies have shown that replacement of these histidines alpha(1) H101, alpha(2) H101, and alpha(3) H126 by arginine, as naturally present in alpha(4) and alpha(6) , leads to benzodiazepine insensitivity of these receptors. Histidine 51-61 immunoglobulin binding protein 1 Homo sapiens 147-154 17928348-5 2007 We identify an invariant series of six cysteine and histidine residues in the CTD of G2 that is essential for incorporation of SSP in the GP-C complex. Histidine 52-61 glycophorin C (Gerbich blood group) Homo sapiens 138-142 29187844-9 2017 speG also affects the expression of genes that have been rarely reported to correlate with polyamine metabolism in Salmonella, including those associated with the periplasmic nitrate reductase system, glucarate metabolism, the phosphotransferase system, cytochromes, and the succinate reductase complex in S. Typhimurium in the mid-log growth phase, as well as those in the ilv-leu and histidine biosynthesis operons of intracellular S. Typhimurium after invasion in Caco-2 cells. Histidine 386-395 striated muscle enriched protein kinase Homo sapiens 0-4 29085768-7 2017 Due to these interactions, the large polycyclic moiety of the ligand would also block further interactions with Hsd6 (prototropic tautomer of His), Asp7, Ser8 and Gly9 that are integral to His6-His13-His14, Arg5-Asp7and Leu34-Gly38 beta-sheets, salt bridges in Glu22-Lys28 and turn conformation Phe19-Gly25. Histidine 142-145 RNA, U1 small nuclear 4 Homo sapiens 112-116 17878162-7 2007 Matrix-assisted laser desorption and ionization time-of-flight mass spectrometry analysis and mutation experiments revealed that PTP1B inactivation was primarily due to covalent attachment of the quinone to Cys-121 of the enzyme, with binding to His-25 and Cys-215 as well. Histidine 246-249 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 129-134 20641605-3 2004 Both GRP and BN share an amidated C-terminus sequence homology of seven amino acids, -Trp-Ala-Val-Gly-His-Leu-Met-NH2. Histidine 102-105 gastrin releasing peptide Homo sapiens 5-8 28455790-5 2017 The pull-down assay was performed using recombinant His-tagged TWEAK and AGEs. Histidine 52-55 TNF superfamily member 12 Homo sapiens 63-68 28807436-3 2017 The designed hybrid molecules, BS-Tat-Ni-NTA, MV1-Tat-Ni-NTA, BS-R9-Ni-NTA, and MV1-R9-Ni-NTA, efficiently degraded His-tagged cellular retinoic acid binding protein 2 via the ubiquitin-proteasome system (UPS). Histidine 116-119 cellular retinoic acid binding protein 2 Homo sapiens 127-167 28613440-2 2017 H3 O+ forms hydrogen bonds (H-bonds) with two histidine side-chains and a backbone carbonyl group in PcyA, whereas H3 O+ forms H-bonds with three acidic residues in XI. Histidine 46-55 H3 clustered histone 15 Homo sapiens 0-4 17767915-6 2007 We further generated histidine-substituted Tca HDAC mutants and investigated their role in biochemical and cellular activity of the enzyme. Histidine 21-30 histone deacetylase 9 Homo sapiens 47-51 17888579-5 2007 This inhibition did not pose any problem in kinetic analysis, for within the relevant Mn2+ concentration range the His-tagged human PEPCK behaved almost identically to the tag-free enzyme. Histidine 115-118 phosphoenolpyruvate carboxykinase 2, mitochondrial Homo sapiens 132-137 17686524-2 2007 To gain insight into the importance of the heme hexacoordination and the coordinated distal histidine in general for the possible physiological functions of these proteins, the distal His(E7) of Arabidopsis thaliana hemoglobin (AHb1) was substituted by a leucine residue. Histidine 184-187 hemoglobin 1 Arabidopsis thaliana 216-226 27915022-0 2017 Concentration dependent survival and neural differentiation of murine embryonic stem cells cultured on polyethylene glycol dimethacrylate hydrogels possessing a continuous concentration gradient of n-cadherin derived peptide His-Ala-Val-Asp-Lle. Histidine 225-228 cadherin 2 Mus musculus 198-208 30108874-4 2017 In particular, the 3,4-dichlorobenzyl derivative 5b showed a comparable or superior activity against all the tested fungal strains to standard drugs, and formed a supramolecular complex with CYP51 via the hydrogen bond between the 4-nitrogen of the triazole nucleus and the histidine residue. Histidine 274-283 lanosterol 14-alpha demethylase Bos taurus 191-196 17924626-12 2007 In another dendrimer, HG3 ((AcIlePro)(8)(DapIleThr)(4)(DapHisAla)(2)DapHisLeuNH2) by contrast, catalysis by a core of three histidine residues is unaffected by the outer dendritic layers. Histidine 124-133 polycystin 1, transient receptor potential channel interacting pseudogene 3 Homo sapiens 22-25 17924654-6 2007 Here, using ThrRS as an example, rapid single-turnover kinetics, mutagenesis, and solvent isotope analysis show that a strictly conserved histidine (between ThrRS and AlaRS) extracts a proton in the chemical step of the editing reaction. Histidine 138-147 threonyl-tRNA synthetase 3 Homo sapiens 12-17 17924654-6 2007 Here, using ThrRS as an example, rapid single-turnover kinetics, mutagenesis, and solvent isotope analysis show that a strictly conserved histidine (between ThrRS and AlaRS) extracts a proton in the chemical step of the editing reaction. Histidine 138-147 threonyl-tRNA synthetase 3 Homo sapiens 157-162 17924654-6 2007 Here, using ThrRS as an example, rapid single-turnover kinetics, mutagenesis, and solvent isotope analysis show that a strictly conserved histidine (between ThrRS and AlaRS) extracts a proton in the chemical step of the editing reaction. Histidine 138-147 alanyl-tRNA synthetase 1 Homo sapiens 167-172 17916624-4 2007 The CO adduct of Ngb displays two CO absorption bands in the IR spectrum, referred to as N(3) (distal histidine in the pocket) and N(0) (distal histidine swung out of the pocket), which have absorption spectra that are almost identical with the Mb mutants L29F and H64V, respectively. Histidine 102-111 neuroglobin Homo sapiens 17-20 17916624-4 2007 The CO adduct of Ngb displays two CO absorption bands in the IR spectrum, referred to as N(3) (distal histidine in the pocket) and N(0) (distal histidine swung out of the pocket), which have absorption spectra that are almost identical with the Mb mutants L29F and H64V, respectively. Histidine 144-153 neuroglobin Homo sapiens 17-20 28566767-6 2017 The "His carrier" (His/His or His/Arg) of rs1229984 (His48Arg) of ADH1B significantly increased gout risk (P = 4.3 x 10-4, odds ratio = 1.76), as did the "non-Lys carrier (Glu/Glu)" of rs671 (Glu504Lys) of ALDH2. Histidine 5-8 alcohol dehydrogenase 1B (class I), beta polypeptide Homo sapiens 66-71 28566767-6 2017 The "His carrier" (His/His or His/Arg) of rs1229984 (His48Arg) of ADH1B significantly increased gout risk (P = 4.3 x 10-4, odds ratio = 1.76), as did the "non-Lys carrier (Glu/Glu)" of rs671 (Glu504Lys) of ALDH2. Histidine 19-22 alcohol dehydrogenase 1B (class I), beta polypeptide Homo sapiens 66-71 28566767-6 2017 The "His carrier" (His/His or His/Arg) of rs1229984 (His48Arg) of ADH1B significantly increased gout risk (P = 4.3 x 10-4, odds ratio = 1.76), as did the "non-Lys carrier (Glu/Glu)" of rs671 (Glu504Lys) of ALDH2. Histidine 19-22 alcohol dehydrogenase 1B (class I), beta polypeptide Homo sapiens 66-71 28270603-3 2017 In Arabidopsis thaliana accession Cvi-0, one of the two copies of a duplicated histidine biosynthesis gene, HISN6A, is mutated, making HISN6B essential. Histidine 79-88 HISTIDINE BIOSYNTHESIS 6B Arabidopsis thaliana 135-141 28323994-5 2017 We have further discovered that the histidine ammonia-lyase (HAL; also known as histidase or histidinase)-2 gene is strongly and specifically activated by T3 in the proliferating adult stem cells of the intestine during metamorphosis, implicating a role of histidine catabolism in the development of adult intestinal stem cells. Histidine 36-45 histidine ammonia-lyase, gene 1 L homeolog Xenopus laevis 61-64 27241012-4 2017 Three Vssc mutations are known: kdr (L1014F), kdr-his (L1014H) and super-kdr (M918T + L1014F). Histidine 50-53 sodium channel protein para-like Musca domestica 6-10 17573342-1 2007 A mutagenic analysis of the amino acid residues His-104 and Cys-166, which are involved in the bi-covalent attachment of FAD to berberine bridge enzyme, was performed. Histidine 48-51 FA complementation group D2 Homo sapiens 121-124 17573342-7 2007 Removal of the cysteine linkage to FAD in the C166A mutein leads to a redox potential of +53 mV, which is in the expected range for flavoproteins with a single covalent attachment of FAD to a His residue via its 8-alpha position. Histidine 192-195 FA complementation group D2 Homo sapiens 35-38 17573342-7 2007 Removal of the cysteine linkage to FAD in the C166A mutein leads to a redox potential of +53 mV, which is in the expected range for flavoproteins with a single covalent attachment of FAD to a His residue via its 8-alpha position. Histidine 192-195 FA complementation group D2 Homo sapiens 183-186 17560742-8 2007 The distal ligand-binding histidine at E7, the proximal heme-binding histidine at F8, and the phenylalanine residue at CD1 were conserved in Mb and Cygb. Histidine 26-35 cytoglobin S homeolog Xenopus laevis 148-152 17560742-8 2007 The distal ligand-binding histidine at E7, the proximal heme-binding histidine at F8, and the phenylalanine residue at CD1 were conserved in Mb and Cygb. Histidine 69-78 cytoglobin S homeolog Xenopus laevis 148-152 28030949-3 2017 Compared to that in the NCS-1 protein of Caenorhabditis elegans, evolution has avoided the placement of histidine residues at positions 102 and 83 in the NCS-1 protein of humans and Xenopus laevis, possibly to decrease the conformational sensitivity to pH gradients in synaptic processes. Histidine 104-113 Neuronal calcium sensor 1 Caenorhabditis elegans 24-29 28030949-3 2017 Compared to that in the NCS-1 protein of Caenorhabditis elegans, evolution has avoided the placement of histidine residues at positions 102 and 83 in the NCS-1 protein of humans and Xenopus laevis, possibly to decrease the conformational sensitivity to pH gradients in synaptic processes. Histidine 104-113 Neuronal calcium sensor 1 Caenorhabditis elegans 154-159 27895119-8 2017 We also showed that replacing the phenylalanine 3.33 in CCR5 TM3 by the corresponding histidine of CCR2 converts J113863 from an antagonist for cell migration and a partial agonist in other assays to a full agonist in all assays. Histidine 86-95 C-C motif chemokine receptor 5 Homo sapiens 56-60 28250719-1 2017 Two new somatostatin analogs with a characteristic part of the sequence -c(Cys-Phe-Trp-Lys-Thr-Cys)- and with two histidine and two aspartic acid moieties in their structures were synthesized and analyzed in terms of their coordination abilities with copper (II) ions. Histidine 114-123 somatostatin Homo sapiens 8-20 27966610-0 2016 Molecular mechanism: the human dopamine transporter histidine 547 regulates basal and HIV-1 Tat protein-inhibited dopamine transport. Histidine 52-61 solute carrier family 6 member 3 Homo sapiens 31-51 27966610-0 2016 Molecular mechanism: the human dopamine transporter histidine 547 regulates basal and HIV-1 Tat protein-inhibited dopamine transport. Histidine 52-61 Tat Human immunodeficiency virus 1 92-95 27934216-5 2016 Here, we combine various biophysical methods to explore the interaction between this Ctr1 segment and metallochaperone Atox1 and clearly demonstrate that the Ctr1 intracellular loop (1) can coordinate Cu(I) via interactions with the side chains of one histidine and two methionine residues and (2) closely interacts with the Atox1 metallochaperone. Histidine 252-261 antioxidant 1 copper chaperone Homo sapiens 119-124 27934216-5 2016 Here, we combine various biophysical methods to explore the interaction between this Ctr1 segment and metallochaperone Atox1 and clearly demonstrate that the Ctr1 intracellular loop (1) can coordinate Cu(I) via interactions with the side chains of one histidine and two methionine residues and (2) closely interacts with the Atox1 metallochaperone. Histidine 252-261 antioxidant 1 copper chaperone Homo sapiens 325-330 27613409-4 2016 Using wild-type as well as Gcn2 knockout and unphosphorylatable eIF2alpha mutant MEFs, we characterized a novel GCN2/eIF2alpha phosphorylation-independent, but ATF4-dependent, pathway that upregulates the expression of CARE-containing genes in MEFs lacking GCN2 or phosphorylatable eIF2alpha when these cells are exposed to methionine-deficient, and to a lesser extent arginine- or histidine-deficient, medium. Histidine 382-391 eukaryotic translation initiation factor 2 alpha kinase 4 Homo sapiens 112-116 27613409-4 2016 Using wild-type as well as Gcn2 knockout and unphosphorylatable eIF2alpha mutant MEFs, we characterized a novel GCN2/eIF2alpha phosphorylation-independent, but ATF4-dependent, pathway that upregulates the expression of CARE-containing genes in MEFs lacking GCN2 or phosphorylatable eIF2alpha when these cells are exposed to methionine-deficient, and to a lesser extent arginine- or histidine-deficient, medium. Histidine 382-391 eukaryotic translation initiation factor 2A Homo sapiens 117-126 27613409-4 2016 Using wild-type as well as Gcn2 knockout and unphosphorylatable eIF2alpha mutant MEFs, we characterized a novel GCN2/eIF2alpha phosphorylation-independent, but ATF4-dependent, pathway that upregulates the expression of CARE-containing genes in MEFs lacking GCN2 or phosphorylatable eIF2alpha when these cells are exposed to methionine-deficient, and to a lesser extent arginine- or histidine-deficient, medium. Histidine 382-391 eukaryotic translation initiation factor 2A Homo sapiens 117-126 27766492-4 2016 Fe(II) DGCR8 RNA-binding heme domain (Rhed) undergoes a pH-dependent transition from 6-coordinate to 5-coordinate, due to protonation and loss of a lysine ligand; the ligand bound throughout the pH change is a histidine. Histidine 210-219 DGCR8 microprocessor complex subunit Homo sapiens 7-12 17602574-2 2007 The active site coordination of CDO comprises a mononuclear iron ligated by the Nepsilon atoms of three protein-derived histidines, thus representing a new variant on the 2-histidine-1-carboxylate (2H1C) facial triad motif. Histidine 120-130 cysteine dioxygenase 1, cytosolic Mus musculus 32-35 17567043-0 2007 Probing the role of the histidine 759 ligand in cobalamin-dependent methionine synthase. Histidine 24-33 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 48-87 17391984-7 2007 An amino acid substitution from Glu 57 to Gly located at one of the four conserved His-Glu (HE) pairs, the potential metal coordination sites, resulted in severe reduction of deoxyhypusine hydroxylase activity. Histidine 83-86 deoxyhypusine hydroxylase Bos taurus 175-200 17515815-11 2007 In the polymorphism of alcohol dehydrogenase (ADH2), prevalence of osteophyte formation without disc height narrowing was less in His/Arg (odds ratio = 0.57, P = 0.041) and Arg/Arg (odds ratio = 0.41, P = 0.18) than His/His. Histidine 130-133 aldo-keto reductase family 1 member A1 Homo sapiens 23-44 17515815-11 2007 In the polymorphism of alcohol dehydrogenase (ADH2), prevalence of osteophyte formation without disc height narrowing was less in His/Arg (odds ratio = 0.57, P = 0.041) and Arg/Arg (odds ratio = 0.41, P = 0.18) than His/His. Histidine 130-133 alcohol dehydrogenase 1B (class I), beta polypeptide Homo sapiens 46-50 17515815-11 2007 In the polymorphism of alcohol dehydrogenase (ADH2), prevalence of osteophyte formation without disc height narrowing was less in His/Arg (odds ratio = 0.57, P = 0.041) and Arg/Arg (odds ratio = 0.41, P = 0.18) than His/His. Histidine 216-219 aldo-keto reductase family 1 member A1 Homo sapiens 23-44 17515815-11 2007 In the polymorphism of alcohol dehydrogenase (ADH2), prevalence of osteophyte formation without disc height narrowing was less in His/Arg (odds ratio = 0.57, P = 0.041) and Arg/Arg (odds ratio = 0.41, P = 0.18) than His/His. Histidine 216-219 alcohol dehydrogenase 1B (class I), beta polypeptide Homo sapiens 46-50 17515815-11 2007 In the polymorphism of alcohol dehydrogenase (ADH2), prevalence of osteophyte formation without disc height narrowing was less in His/Arg (odds ratio = 0.57, P = 0.041) and Arg/Arg (odds ratio = 0.41, P = 0.18) than His/His. Histidine 216-219 aldo-keto reductase family 1 member A1 Homo sapiens 23-44 17515815-11 2007 In the polymorphism of alcohol dehydrogenase (ADH2), prevalence of osteophyte formation without disc height narrowing was less in His/Arg (odds ratio = 0.57, P = 0.041) and Arg/Arg (odds ratio = 0.41, P = 0.18) than His/His. Histidine 216-219 alcohol dehydrogenase 1B (class I), beta polypeptide Homo sapiens 46-50 27825818-3 2016 Therefore, ligand binding to the Ngb metal center is limited from the dissociation of the distal His(E7)64-Fe bond. Histidine 97-100 neuroglobin Homo sapiens 33-36 27346274-11 2016 Additional mutants in EC1/TM3 explored the molecular basis for these changes demonstrated in EC1, particularly important is the presence of aromatic-interactions by His(107), rather than hydrogen-bonding or charge-charge interactions, for determining Bantag-1 high affinity/selectivity. Histidine 165-168 tropomyosin 3 Homo sapiens 26-29 27387499-4 2016 We have focused our attention on active-site residues of PRMT7 from the protozoan Trypanosoma brucei We have designed 26 single and double mutations in the active site, including residues in the Glu-Xaa8-Glu (double E) loop and the Met-Gln-Trp sequence of the canonical Thr-His-Trp (THW) loop known to interact with the methyl-accepting substrate arginine. Histidine 274-277 protein arginine methyltransferase 7 Homo sapiens 57-62 27284165-12 2016 A corresponding histidine insertion into the Gld2 active site alters substrate specificity from ATP to UTP. Histidine 16-25 terminal nucleotidyltransferase 2 Homo sapiens 45-49 27250920-3 2016 This combined computational-experimental study demonstrates that histidine-547 (H547) of hDAT plays a crucial role in the hDAT-Tat binding and dopamine uptake by hDAT, and that the H547A mutation can not only considerably attenuate Tat-induced inhibition of dopamine uptake, but also significantly increase the Vmax of hDAT for dopamine uptake. Histidine 65-74 solute carrier family 6 member 3 Homo sapiens 89-93 27250920-3 2016 This combined computational-experimental study demonstrates that histidine-547 (H547) of hDAT plays a crucial role in the hDAT-Tat binding and dopamine uptake by hDAT, and that the H547A mutation can not only considerably attenuate Tat-induced inhibition of dopamine uptake, but also significantly increase the Vmax of hDAT for dopamine uptake. Histidine 65-74 solute carrier family 6 member 3 Homo sapiens 122-126 27250920-3 2016 This combined computational-experimental study demonstrates that histidine-547 (H547) of hDAT plays a crucial role in the hDAT-Tat binding and dopamine uptake by hDAT, and that the H547A mutation can not only considerably attenuate Tat-induced inhibition of dopamine uptake, but also significantly increase the Vmax of hDAT for dopamine uptake. Histidine 65-74 solute carrier family 6 member 3 Homo sapiens 122-126 27250920-3 2016 This combined computational-experimental study demonstrates that histidine-547 (H547) of hDAT plays a crucial role in the hDAT-Tat binding and dopamine uptake by hDAT, and that the H547A mutation can not only considerably attenuate Tat-induced inhibition of dopamine uptake, but also significantly increase the Vmax of hDAT for dopamine uptake. Histidine 65-74 solute carrier family 6 member 3 Homo sapiens 122-126 26992901-9 2016 ADH1B His/Arg had an OR of 1.98 (1.20-3.24, P = 0.007) compared with His/His. Histidine 6-9 alcohol dehydrogenase 1B (class I), beta polypeptide Homo sapiens 0-5 26756542-0 2016 Identification of putative unfolding intermediates of the mutant His-107-tyr of human carbonic anhydrase II in a multidimensional property space. Histidine 65-68 carbonic anhydrase 2 Homo sapiens 86-107 17419840-8 2007 The growth and uptake studies identified glutamate, histidine and neutral amino acids, including phenylalanine, as physiological substrates for AAP1, whereas aspartate, lysine and arginine are not. Histidine 52-61 amino acid permease 1 Arabidopsis thaliana 144-148 17319695-1 2007 Histidine at position 64 (His64) in human carbonic anhydrase II (HCA II) is believed to be the proton acceptor in the hydration direction and the proton donor in the dehydration direction for the rate-limiting proton transfer (PT) event. Histidine 0-9 carbonic anhydrase 2 Homo sapiens 42-63 17227754-9 2007 The catalytic function of HS-2OST appears to involve two histidine residues (His140 and His142), whereas only one histidine (His168) of CS 2-OST is likely to be critical. Histidine 114-123 Chitin synthase 2 Drosophila melanogaster 136-140 26756542-9 2016 We have focused on the application of this method to partition a wide array of conformations of wild type human carbonic anhydrase II (HCA II) and its unstable mutant His-107-Tyr along dmean by sampling a 35-dimensional property space. Histidine 167-170 carbonic anhydrase 2 Homo sapiens 112-133 26918510-2 2016 Histidine-tagged (His6) VC1-RAGE domain was covalently bonded to Cu(II) or Ni(II) complexes with dipyrromethene (DPM) self-assembled on gold surface. Histidine 0-9 advanced glycosylation end-product specific receptor Homo sapiens 28-32 27136534-4 2016 Absorption spectra of AHbs distal histidine mutants showed that AHb1 mutant (H69L) is a stable pentacoordinate high-spin species in both ferrous and ferric states, whereas heme iron in AHb2 mutant (H66L) is hexacoordinated low-spin with Lys69 as the sixth ligand. Histidine 34-43 hemoglobin 1 Arabidopsis thaliana 64-68 26621552-6 2016 Taking advantage of its N-terminal His-tag, rLF was then purified with Ni-affinity chromatography. Histidine 35-38 RLF zinc finger Rattus norvegicus 44-47 17352366-6 2007 RESULTS: Seventy patients (14%) were homozygous for the histidine variant (HH) of CFH, 237 (48%) were heterozygous for the histidine variant (HY), and 186 (38%) were homozygous for the tyrosine variant (YY). Histidine 56-65 complement factor H Homo sapiens 82-85 17079265-8 2006 HAP2 is predicted to encode a protein with an N-terminal secretion signal, a single transmembrane domain and a C-terminal histidine-rich domain. Histidine 122-131 hapless 2 Arabidopsis thaliana 0-4 16985102-12 2006 The increase in catalytic efficiency observed for Pro360 in human FMO3 was also observed when the His of FMO1 was replaced by Pro at loci 360. Histidine 98-101 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 66-70 17078101-5 2006 We found that among GSTT1(+) individuals the DEB-induced SCE level was significantly lower when the EPHX 139 codon was His/Arg rather than His/His. Histidine 119-122 glutathione S-transferase theta 1 Homo sapiens 20-25 17078101-5 2006 We found that among GSTT1(+) individuals the DEB-induced SCE level was significantly lower when the EPHX 139 codon was His/Arg rather than His/His. Histidine 139-142 glutathione S-transferase theta 1 Homo sapiens 20-25 17078101-5 2006 We found that among GSTT1(+) individuals the DEB-induced SCE level was significantly lower when the EPHX 139 codon was His/Arg rather than His/His. Histidine 139-142 glutathione S-transferase theta 1 Homo sapiens 20-25 26657863-6 2016 Progesterone receptor membrane component-1 (PGRMC1) was required for HIS-dependent increases in hepcidin biosynthesis, as PGRMC1 depletion in cultured hepatoma cells and zebrafish blocked the ability of HISs to increase hepcidin mRNA levels. Histidine 69-72 hepcidin antimicrobial peptide Mus musculus 220-228 26641249-3 2015 We found that two small paralogous nickel-binding proteins with high content in Histidine (Hpn and Hpn-2) play a central role in maintaining non-toxic intracellular nickel content and in controlling its intracellular trafficking. Histidine 80-89 hepsin Mus musculus 91-94 26641249-3 2015 We found that two small paralogous nickel-binding proteins with high content in Histidine (Hpn and Hpn-2) play a central role in maintaining non-toxic intracellular nickel content and in controlling its intracellular trafficking. Histidine 80-89 hepsin Mus musculus 99-102 26311893-4 2015 In contrast, uncleaved, histidine-tagged Foldon (Fd) domain-containing gp140 proteins (gp140UNC-Fd-His), based on the same env genes, very rarely form native-like trimers, a finding that is consistent with their antigenic and biophysical properties and glycan composition. Histidine 24-33 endogenous retrovirus group K member 20 Homo sapiens 123-126 26585511-5 2015 With molecular dynamics simulations, this effect was traced to a histidine residue (H95) located in the cytoplasmic lumen of AQP4. Histidine 65-74 aquaporin 4 Homo sapiens 125-129 26409900-3 2015 HPRG has been reported to bind various ligands and to modulate angiogenesis via the histidine residues of the HPRR. Histidine 84-93 histidine rich glycoprotein Homo sapiens 0-4 26397724-4 2015 Molecular docking of 1 to an X-ray structure of CXCR4 showed that the l-Arg guanidino group of 1 forms polar interactions with His(113) and Asp(171) and the (pyridin-2-ylmethyl)amino moiety is anchored by Asp(262) and His(281), whereas the naphthalene ring is tightly packed in a hydrophobic subpocket formed by the aromatic side chains of Trp(94), Tyr(45), and Tyr(116). Histidine 127-130 C-X-C motif chemokine receptor 4 Homo sapiens 48-53 26397724-4 2015 Molecular docking of 1 to an X-ray structure of CXCR4 showed that the l-Arg guanidino group of 1 forms polar interactions with His(113) and Asp(171) and the (pyridin-2-ylmethyl)amino moiety is anchored by Asp(262) and His(281), whereas the naphthalene ring is tightly packed in a hydrophobic subpocket formed by the aromatic side chains of Trp(94), Tyr(45), and Tyr(116). Histidine 218-221 C-X-C motif chemokine receptor 4 Homo sapiens 48-53 26481857-7 2015 Moreover, histamine upregulated the GTP-bound small GTPase Rac1, while a Rac1 inhibitor, NSC23766, abrogated the neuroprotection of histidine and its promotion of astrocyte migration. Histidine 132-141 Rac family small GTPase 1 Homo sapiens 59-63 17081196-4 2006 In this study, recombinant prolidase was produced as a fusion protein with an N-terminal histidine tag in eukaryotic and prokaryotic hosts and purified in a single step using immobilized metal affinity chromatography. Histidine 89-98 peptidase D Homo sapiens 27-36 17107012-3 2006 Indeed, we show here that histidine-tagged phosducin-like protein (His-PhLP) binds with high selectivity to both Ni2+-treated surface DNA and DNA-templated nickel metal to create linear protein assemblies on surfaces. Histidine 26-35 phosducin Homo sapiens 71-75 17107012-3 2006 Indeed, we show here that histidine-tagged phosducin-like protein (His-PhLP) binds with high selectivity to both Ni2+-treated surface DNA and DNA-templated nickel metal to create linear protein assemblies on surfaces. Histidine 67-70 phosducin Homo sapiens 71-75 17107012-4 2006 The association of His-PhLP with DNA-templated nickel ions or metal is reversible under appropriate rinsing conditions. Histidine 19-22 phosducin Homo sapiens 23-27 16787919-0 2006 His-384 allotypic variant of factor H associated with age-related macular degeneration has different heparin binding properties from the non-disease-associated form. Histidine 0-3 complement factor H Homo sapiens 29-37 16817320-0 2006 Histidine 89 is an essential residue for Hsp70 in the phosphate transfer reaction. Histidine 0-9 heat shock protein family A (Hsp70) member 4 Homo sapiens 41-46 16817320-3 2006 In this study we determined the site of histidine phosphorylation of Hsp70 as an intermediate in the process of phosphate transfer reaction by site-directed mutagenesis. Histidine 40-49 heat shock protein family A (Hsp70) member 4 Homo sapiens 69-74 16547001-0 2006 Aprataxin forms a discrete branch in the HIT (histidine triad) superfamily of proteins with both DNA/RNA binding and nucleotide hydrolase activities. Histidine 46-55 aprataxin Homo sapiens 0-9 16547001-8 2006 Finally, comparison of sequence relationships between the histidine triad superfamily members shows that Aprataxin forms a distinct branch in this superfamily. Histidine 58-67 aprataxin Homo sapiens 105-114 16647063-0 2006 A critical role for the histidine residues in the catalytic function of acyl-CoA:cholesterol acyltransferase catalysis: evidence for catalytic difference between ACAT1 and ACAT2. Histidine 24-33 acetyl-CoA acetyltransferase 2 Homo sapiens 172-177 16647063-7 2006 These results demonstrate that the histidine residues located at the active site are very crucial both for the catalytic activity of the enzyme and for distinguishing ACAT1 from ACAT2 with respect to enzyme catalysis and substrate specificity. Histidine 35-44 acetyl-CoA acetyltransferase 2 Homo sapiens 178-183 16332725-6 2006 Individuals having ALDH2 Glu/Glu with ADH2 Arg+, ALDH2 Lys+ with ADH2 His/His and ALDH2 Lys+ with ADH2 Arg+ showed ORs of 0.10(0.04-0.21), 0.10 (0.06-0.19) and 1.36 (0.94-1.97), respectively, compared with ALDH2 Glu/Glu with ADH2 His/His. Histidine 70-73 alcohol dehydrogenase 1B (class I), beta polypeptide Homo sapiens 65-69 16332725-6 2006 Individuals having ALDH2 Glu/Glu with ADH2 Arg+, ALDH2 Lys+ with ADH2 His/His and ALDH2 Lys+ with ADH2 Arg+ showed ORs of 0.10(0.04-0.21), 0.10 (0.06-0.19) and 1.36 (0.94-1.97), respectively, compared with ALDH2 Glu/Glu with ADH2 His/His. Histidine 70-73 alcohol dehydrogenase 1B (class I), beta polypeptide Homo sapiens 65-69 16332725-6 2006 Individuals having ALDH2 Glu/Glu with ADH2 Arg+, ALDH2 Lys+ with ADH2 His/His and ALDH2 Lys+ with ADH2 Arg+ showed ORs of 0.10(0.04-0.21), 0.10 (0.06-0.19) and 1.36 (0.94-1.97), respectively, compared with ALDH2 Glu/Glu with ADH2 His/His. Histidine 70-73 alcohol dehydrogenase 1B (class I), beta polypeptide Homo sapiens 65-69 16510783-4 2006 The gene HIS3 from the histidine synthesis pathway was recruited to the GAL system, responsible for galactose utilization in the yeast S. cerevisiae. Histidine 23-32 imidazoleglycerol-phosphate dehydratase HIS3 Saccharomyces cerevisiae S288C 9-13 16510783-5 2006 Following a switch from galactose to glucose--from induced to repressed conditions of the GAL system--in histidine-lacking chemostats (where the recruited HIS3 is essential), the regulatory system reprogrammed to adaptively tune HIS3 expression, allowing the cells to grow competitively in pure glucose. Histidine 105-114 imidazoleglycerol-phosphate dehydratase HIS3 Saccharomyces cerevisiae S288C 155-159 16510783-5 2006 Following a switch from galactose to glucose--from induced to repressed conditions of the GAL system--in histidine-lacking chemostats (where the recruited HIS3 is essential), the regulatory system reprogrammed to adaptively tune HIS3 expression, allowing the cells to grow competitively in pure glucose. Histidine 105-114 imidazoleglycerol-phosphate dehydratase HIS3 Saccharomyces cerevisiae S288C 229-233 26481857-7 2015 Moreover, histamine upregulated the GTP-bound small GTPase Rac1, while a Rac1 inhibitor, NSC23766, abrogated the neuroprotection of histidine and its promotion of astrocyte migration. Histidine 132-141 Rac family small GTPase 1 Homo sapiens 73-77 26088577-8 2015 The NDPKB-induced increase in ISK4 was prevented by protein histidine phosphatase 1, but not an inactive protein histidine phosphatase 1 mutant indicating that ISK4 is regulated via histidine phosphorylation in proliferating VSMC; moreover, genetic NDPKB ablation reduced ISK4 by 50% suggesting a constitutive activation of ISK4 in proliferating VSMC. Histidine 60-69 NME/NM23 nucleoside diphosphate kinase 2 Mus musculus 4-9 26191403-1 2015 TRH-like peptides were synthesized in which the critical N-terminus residue L-pGlu was replaced with various heteroaromatic rings, and the central residue histidine with 1-alkyl-L-histidines. Histidine 155-164 thyrotropin releasing hormone Mus musculus 0-3 25888615-8 2015 Ubiquitination on both HIS(6x)-HA(3x)-IAA1 and Lys-less HIS(6x)-HA(3x)-IAA1 proteins was sensitive to sodium hydroxide treatment, indicative of ubiquitin oxyester formation on serine or threonine residues. Histidine 23-26 indole-3-acetic acid inducible Arabidopsis thaliana 38-42 25542299-9 2015 RESULTS: Significantly superior activities were found in 34 of the approximately 2000 mutants analyzed, and the majority of the superior GSTs featured His and Gly residues in one of the three active-site positions subjected to mutagenesis. Histidine 151-154 glutathione S-transferase alpha 2 Homo sapiens 137-141 16761408-14 2006 The results of SDS-PAGE and Western blot showed the rE4 was expressed mainly to form the inclusion body, and to fuse with his-tag (rE4/His), that was soluble and had a molecular weight as about 34 KDa. Histidine 122-125 WAP four-disulfide core domain 2 Rattus norvegicus 52-55 16761408-14 2006 The results of SDS-PAGE and Western blot showed the rE4 was expressed mainly to form the inclusion body, and to fuse with his-tag (rE4/His), that was soluble and had a molecular weight as about 34 KDa. Histidine 122-125 WAP four-disulfide core domain 2 Rattus norvegicus 131-134 16490786-6 2006 A purified histidine-tagged Pte1p showed high activity toward short and medium chain length acyl-CoAs, including butyryl-CoA, decanoyl-CoA and 8-methyl-nonanoyl-CoA. Histidine 11-20 palmitoyl-CoA hydrolase Saccharomyces cerevisiae S288C 28-33 16297612-1 2006 An olfactory receptor protein of C. elegans, ODR-10, was expressed in Escherichia coli as a fusion protein, with GST and 6x His-tag. Histidine 124-127 Serpentine receptor class r-10 Caenorhabditis elegans 45-51 16584196-6 2006 This pK(H) is low for alkaline conformers involving lysine-heme ligation but is consistent with the pK(a) of the highest of three ionizable groups which modulate formation of the histidine-heme alkaline conformer of a His 73 variant of iso-1-cytochrome c [Martinez, R. E., and Bowler, B. E. (2004) J. Histidine 179-188 eukaryotic translation initiation factor 1 Homo sapiens 236-241 16584196-6 2006 This pK(H) is low for alkaline conformers involving lysine-heme ligation but is consistent with the pK(a) of the highest of three ionizable groups which modulate formation of the histidine-heme alkaline conformer of a His 73 variant of iso-1-cytochrome c [Martinez, R. E., and Bowler, B. E. (2004) J. Histidine 218-221 eukaryotic translation initiation factor 1 Homo sapiens 236-241 25225131-7 2015 This observation was due to the protonation of a histidine residue as an imidazolium cation, which was not accessible when TTR was in its tetrameric structure. Histidine 49-58 transthyretin Homo sapiens 123-126 25762074-3 2015 Docking analysis of MAD-28 to mNT/NAF-1 revealed that in contrast to CLV, which formed a hydrogen bond network that stabilized the 2Fe-2S clusters of these proteins, MAD-28 broke the coordinative bond between the His ligand and the cluster"s Fe of mNT/NAF-1. Histidine 213-216 CDGSH iron sulfur domain 2 Homo sapiens 34-39 25604895-2 2015 Kti11 was additionally shown to be implicated in the biosynthesis of diphthamide, a post-translationally modified histidine of translation elongation factor 2. Histidine 114-123 diphthamide biosynthesis 3 Homo sapiens 0-5 25521423-0 2015 NMR studies of active-site properties of human carbonic anhydrase II by using (15) N-labeled 4-methylimidazole as a local probe and histidine hydrogen-bond correlations. Histidine 132-141 carbonic anhydrase 2 Homo sapiens 47-68 25505265-5 2015 We show that HHAT is comprised of ten transmembrane domains and two reentrant loops with the critical His and Asp residues on opposite sides of the endoplasmic reticulum membrane. Histidine 102-105 hedgehog acyltransferase Homo sapiens 13-17 25658096-3 2015 We demonstrate that these two sites are readily phosphorylated by NDR and LATS kinases in vitro, and this requires the presence of an upstream -5 histidine residue. Histidine 146-155 serine/threonine kinase 38 Homo sapiens 66-69 25252293-3 2015 Particularly, the relation between 2827 A>G polymorphism of the SIRT1 positioned on exon 2, leading to conversion of histidine to arginine, and the formation of CVD is not known yet. Histidine 120-129 sirtuin 1 Homo sapiens 67-72 25554218-5 2015 ML-18 and EMY-98 inhibited specific (125)I-BA1 (DTyr-Gln-Trp-Ala-Val-betaAla-His-Phe-Nle-NH2)BB(6-14) binding to NCI-H1299 lung cancer cells stably transfected with BRS-3 with IC50 values of 4.8 and >100muM, respectively. Histidine 77-80 gastrin releasing peptide Homo sapiens 93-95 25323582-7 2015 The ADH1B*47Arg allele was found to be associated with increased risk of HNC in Asians, with the pooled odds ratios (ORs) (Arg/Arg vs. Arg/His + His/His: OR = 2.35, 95% CI = 1.56-3.55, P < 0.0001) in all eight studies. Histidine 139-142 alcohol dehydrogenase 1B (class I), beta polypeptide Homo sapiens 4-9 25323582-7 2015 The ADH1B*47Arg allele was found to be associated with increased risk of HNC in Asians, with the pooled odds ratios (ORs) (Arg/Arg vs. Arg/His + His/His: OR = 2.35, 95% CI = 1.56-3.55, P < 0.0001) in all eight studies. Histidine 145-148 alcohol dehydrogenase 1B (class I), beta polypeptide Homo sapiens 4-9 25323582-7 2015 The ADH1B*47Arg allele was found to be associated with increased risk of HNC in Asians, with the pooled odds ratios (ORs) (Arg/Arg vs. Arg/His + His/His: OR = 2.35, 95% CI = 1.56-3.55, P < 0.0001) in all eight studies. Histidine 145-148 alcohol dehydrogenase 1B (class I), beta polypeptide Homo sapiens 4-9 25554946-14 2015 Conversely, in Ngb, the reduction mechanism does not rely on the delivery of a proton from the histidine side chain, as His64 mutants show the fastest reduction rates. Histidine 95-104 neuroglobin Homo sapiens 15-18 16602729-7 2006 The polymers were used to purify residues 230-534 of the histidine-tagged breast cancer susceptibility protein his6-BRCA1. Histidine 57-66 BRCA1 DNA repair associated Homo sapiens 116-121 16567399-5 2006 On the other hand, a mutant chicken Src, in which the His-122 residue is replaced by Arg, showed decreased recognition by mAb327. Histidine 54-57 SRC proto-oncogene, non-receptor tyrosine kinase Gallus gallus 36-39 16210335-1 2006 In the present study, we examined the role in hematopoiesis of cationic amino acid transporter 1 (CAT1), which transports L-arginine, L-lysine, L-ornithine, and L-histidine. Histidine 161-172 solute carrier family 7 member 1 Homo sapiens 63-96 16210335-1 2006 In the present study, we examined the role in hematopoiesis of cationic amino acid transporter 1 (CAT1), which transports L-arginine, L-lysine, L-ornithine, and L-histidine. Histidine 161-172 solute carrier family 7 member 1 Homo sapiens 98-102 16363808-3 2005 Two cysteine residues (C45 and C49) in the sequence CXXXCP and a histidine (H135) approximately 90 residues toward the C-terminus are conserved in Sco from bacteria, yeast, and humans. Histidine 65-74 DELYQ11 Homo sapiens 147-150 25542361-1 2015 We report a turn-on phosphorescence probe for detection of histidine based on Co(2+)-adsorbed N-acetyl-L-cysteine (NAC) capped Mn: ZnS quantum dots (QDs) which is directly synthesized by the hydrothermal method. Histidine 59-68 X-linked Kx blood group Homo sapiens 115-118 25542361-3 2015 The phosphorescence of Co(2+)-adsorbed NAC-Mn: ZnS QDs can be recovered by binding of Co(2+) with histidine. Histidine 98-107 X-linked Kx blood group Homo sapiens 39-42 25542361-7 2015 Co(2+)-adsorbed NAC-Mn: ZnS QDs show high sensitivity and good selectivity to histidine over other amino acids, metal ions and co-existing substances. Histidine 78-87 X-linked Kx blood group Homo sapiens 16-19 25620968-3 2014 Two myo-inositol monophosphatase -like (IMPL) genes in Arabidopsis encode chloroplast proteins with homology to the prokaryotic IMPs and one of these, IMPL2, can complement a bacterial histidinol 1-phosphate phosphatase mutant defective in histidine synthesis, indicating an important role for IMPL2 in amino acid synthesis. Histidine 240-249 inositol monophosphatase family protein Arabidopsis thaliana 151-156 25620968-7 2014 Identification and characterization of impl1 and impl2 mutants revealed no viable mutants for IMPL1, while two different impl2 mutants were identified and shown to be severely compromised in growth, which can be rescued by histidine. Histidine 223-232 inositol monophosphatase family protein Arabidopsis thaliana 121-126 25620968-8 2014 Analyses of metabolite levels in impl2 and complemented mutants reveals impl2 mutant growth is impacted by alterations in the histidine biosynthesis pathway, but does not impact myo-inositol synthesis. Histidine 126-135 inositol monophosphatase family protein Arabidopsis thaliana 72-77 16215176-6 2005 Furthermore, the inactivation of C. albicans Gcn2 only partially attenuates growth under amino acid starvation conditions and resistance to the histidine analogue 3-aminotriazole. Histidine 144-153 serine/threonine-protein kinase GCN2 Saccharomyces cerevisiae S288C 45-49 16441176-6 2005 The polymers have lower critical solution temperatures which occur at sub-ambient temperatures and have proven useful in the affinity precipitation of proteins which are particularly temperature sensitive, e.g. the histidine-tagged protein fragment BRCA1. Histidine 215-224 BRCA1 DNA repair associated Homo sapiens 249-254 15993513-2 2005 A series of tetrapeptides, based on Tic-DPhe-Arg-Trp-NH2-a mimic of the putative message sequence "His-Phe-Arg-Trp" and modified at the DPhe position, were prepared and pharmacologically characterized for potency and selectivity. Histidine 99-102 aryl hydrocarbon receptor nuclear translocator-like Rattus norvegicus 36-39 16084396-4 2005 Isoelectric focusing (IEF) and Western analyses indicated that the apparent V(max)=192+/-13 U/mg and K(m) (PDK-Tide)=55+/-10 microM of purified His(6)-PDK1 results from a mixture of at least three different phospho-specific isoforms (pI values of 6.8, 6.5, and 6.4). Histidine 144-147 pyruvate dehydrogenase kinase 1 Homo sapiens 151-155 16000726-3 2005 An E. coli IroD protein with an N-terminal His-tag cleaved cyclic salmochelin S4 to the linear trimer salmochelin S2, the dimer salmochelin S1, and the monomers dihydroxybenzoylserine and C-glucosylated dihydroxybenzoylserine (salmochelin SX, pacifarinic acid). Histidine 43-46 IroD Escherichia coli 11-15 15876520-4 2005 Both of the siblings were compound heterozygotes with aprataxin gene mutations, 689 insT and G692A, in exon 5 that encodes the histidine triad domain of the aprataxin protein. Histidine 127-136 aprataxin Homo sapiens 54-63 15876520-4 2005 Both of the siblings were compound heterozygotes with aprataxin gene mutations, 689 insT and G692A, in exon 5 that encodes the histidine triad domain of the aprataxin protein. Histidine 127-136 aprataxin Homo sapiens 157-166 15870096-0 2005 ALBINO AND PALE GREEN 10 encodes BBMII isomerase involved in histidine biosynthesis in Arabidopsis thaliana. Histidine 61-70 Aldolase-type TIM barrel family protein Arabidopsis thaliana 33-48 15870096-3 2005 The morphological abnormality of apg10 was recovered by histidine supplementation. Histidine 56-65 Aldolase-type TIM barrel family protein Arabidopsis thaliana 33-38 15870096-4 2005 The histidine limitation induced by apg10 mutation causes dynamic changes of the free amino acid profile, suggesting the existence of a cross-pathway regulatory mechanism of amino acid biosynthesis in plants. Histidine 4-13 Aldolase-type TIM barrel family protein Arabidopsis thaliana 36-41 16029163-1 2005 Human brain serine racemase (hSR) was expressed in large amounts in E. coli with N-terminal His-tag (His-hSR). Histidine 92-95 HSR Homo sapiens 29-32 16029163-1 2005 Human brain serine racemase (hSR) was expressed in large amounts in E. coli with N-terminal His-tag (His-hSR). Histidine 101-104 HSR Homo sapiens 29-32 16029163-1 2005 Human brain serine racemase (hSR) was expressed in large amounts in E. coli with N-terminal His-tag (His-hSR). Histidine 101-104 HSR Homo sapiens 105-108 16029163-3 2005 Purified His-hSR was refolded in Tween 20/cycloamylose with approximately 50% efficiency, and refolded His-hSR was isolated by Q Sepharose column chromatography. Histidine 9-12 HSR Homo sapiens 13-16 16029163-3 2005 Purified His-hSR was refolded in Tween 20/cycloamylose with approximately 50% efficiency, and refolded His-hSR was isolated by Q Sepharose column chromatography. Histidine 9-12 HSR Homo sapiens 107-110 16029163-5 2005 His-hSR catalyzed the elimination of L-Ser as well as L-Ser-O-sulfate to form pyruvate. Histidine 0-3 HSR Homo sapiens 4-7 15790557-3 2005 Disease-associated mutations in Aprataxin target a histidine triad domain that is similar to Hint, a universally conserved AMP-lysine hydrolase, or truncate the protein NH2-terminal to a zinc finger. Histidine 51-60 aprataxin Homo sapiens 32-41 15749695-1 2005 The active site glutamate (Glu(111)) and the active site histidine (His(112)) of insulin-degrading enzyme (IDE) were mutated. Histidine 57-66 insulin degrading enzyme Homo sapiens 81-105 15749695-1 2005 The active site glutamate (Glu(111)) and the active site histidine (His(112)) of insulin-degrading enzyme (IDE) were mutated. Histidine 57-66 insulin degrading enzyme Homo sapiens 107-110 15749695-1 2005 The active site glutamate (Glu(111)) and the active site histidine (His(112)) of insulin-degrading enzyme (IDE) were mutated. Histidine 68-71 insulin degrading enzyme Homo sapiens 81-105 15749695-1 2005 The active site glutamate (Glu(111)) and the active site histidine (His(112)) of insulin-degrading enzyme (IDE) were mutated. Histidine 68-71 insulin degrading enzyme Homo sapiens 107-110 15761121-3 2005 Significant association (P = 4.95 x 10(-10)) was identified within the regulation of complement activation locus and was centered over a tyrosine-402 --> histidine-402 protein polymorphism in the gene encoding complement factor H. Histidine 157-166 complement factor H Homo sapiens 213-232 15574419-1 2005 To compare kinetic properties of homologous isozymes of NADP+-specific isocitrate dehydrogenase, histidine-tagged forms of yeast mitochondrial (IDP1) and cytosolic (IDP2) enzymes were expressed and purified. Histidine 97-106 isocitrate dehydrogenase (NADP(+)) IDP1 Saccharomyces cerevisiae S288C 144-148 15665078-7 2005 Sequence homology analysis indicated that, with one exception, the histidine residues that were previously shown to be important for pH sensing by OGR1, GPR4, and TDAG8 were not conserved in the G2A receptor. Histidine 67-76 G protein-coupled receptor 68 Mus musculus 147-151 15665078-7 2005 Sequence homology analysis indicated that, with one exception, the histidine residues that were previously shown to be important for pH sensing by OGR1, GPR4, and TDAG8 were not conserved in the G2A receptor. Histidine 67-76 G-protein coupled receptor 65 Mus musculus 163-168 15574461-3 2005 To clarify the molecular mechanisms of this low level of activity, we co-expressed human ferrochelatase carrying His- and HA-tags in a tandem fashion in Escherichia coli. Histidine 113-116 ferrochelatase Homo sapiens 89-103 15692735-3 2005 This report describes the optimisation of 6-fluorotryptophan incorporation in a His-tagged human serum retinol-binding protein (RBP), a disulphide bonded beta-barrel protein. Histidine 80-83 retinol binding protein 4 Homo sapiens 128-131 15610045-1 2004 The human DNA repair protein, hXRCC1, which is required for DNA single-strand break repair and genetic stability was produced as a histidine-tagged polypeptide in Escherichia coli, purified by affinity chromatography, and subjected to sedimentation and spectroscopic analyses. Histidine 131-140 X-ray repair cross complementing 1 Homo sapiens 30-36 25620968-9 2014 Together, these data indicate that IMPL2 functions in the histidine biosynthetic pathway, while IMP and IMPL1 catalyze the hydrolysis of inositol- and galactose-phosphates in the plant cell. Histidine 58-67 inositol monophosphatase family protein Arabidopsis thaliana 35-40 25699148-2 2015 Replacement of His(6) by an aminoindoloazepinone (Aia) or aminobenzazepinone (Aba) moiety led to hMC4R and hMC5R selective agonist and antagonist ligands, respectively (tetrapeptides 1 to 3 and 4, respectively). Histidine 15-18 melanocortin 4 receptor Homo sapiens 97-102 25699148-2 2015 Replacement of His(6) by an aminoindoloazepinone (Aia) or aminobenzazepinone (Aba) moiety led to hMC4R and hMC5R selective agonist and antagonist ligands, respectively (tetrapeptides 1 to 3 and 4, respectively). Histidine 15-18 melanocortin 5 receptor Homo sapiens 107-112 25230085-1 2014 Within the phospholipase A2 (PLA2) superfamily, secreted PLA2 (sPLA2) enzymes comprise the largest family that contains 11 to 12 mammalian isoforms with a conserved His-Asp catalytic dyad. Histidine 165-168 phospholipase A2 group IIA Homo sapiens 63-68 25058381-1 2014 Gaduscidin-1 and -2 (GAD-1 and GAD-2) are antimicrobial peptides (AMPs) that contain several histidine residues and are thus expected to exhibit pH-dependent activity. Histidine 93-102 glutamate decarboxylase 1 Homo sapiens 21-26 25185576-7 2014 DNA sequence analyses of FH domains 6 and 7 from macaques with high or low FH binding showed a polymorphism at residue 352 in domain 6, with Tyr being associated with high binding and His with low binding. Histidine 184-187 complement factor H Homo sapiens 25-27 25473735-10 2014 Furthermore, the increased prevalence of incomplete RBBB in the absence of cardiomyopathy suggests a selective involvement of the His-Purkinje system in FSHD. Histidine 130-133 FSHMD1A Homo sapiens 153-157 15561858-5 2004 PCR amplified a blaKPC allele encoding a novel variant, KPC-3, with a His(272)-->Tyr substitution not found in KPC-2; other carbapenemase genes were absent. Histidine 70-73 KPC-3 Klebsiella pneumoniae 56-61 15325515-4 2004 We cloned and expressed the ORF6 gene, which encodes the M/VP-2, as a fusion protein with a polyhistidine metal-binding tag (6 x His-tag) in Autographa californica nuclear polyhedrosis virus (baculovirus) under the control of the polyhedrin promoter. Histidine 129-132 dachsous cadherin-related 1 Homo sapiens 57-63 15450853-5 2004 Vibrio PGI contains motifs for the serine, histidine and aspartic acid active sites of the subtilase family of serine proteases which form a putative catalytic triad consisting of His534 and Ser159 on the 60.8-kDa subunit and Asp53 on the 23.4-kDa subunit. Histidine 43-52 glucose-6-phosphate isomerase Oryctolagus cuniculus 7-10 15479231-0 2004 Investigation of the contribution of histidine 119 to the conduction of protons through human Nox2. Histidine 37-46 cytochrome b-245 beta chain Homo sapiens 94-98 15479231-3 2004 To investigate the possible role that these histidine residues might play in the conduction of protons through Nox2, we have introduced both paired and single mutations into these histidine residues. Histidine 44-53 cytochrome b-245 beta chain Homo sapiens 111-115 15479231-3 2004 To investigate the possible role that these histidine residues might play in the conduction of protons through Nox2, we have introduced both paired and single mutations into these histidine residues. Histidine 180-189 cytochrome b-245 beta chain Homo sapiens 111-115 15475297-4 2004 The domains found in Graal proteins are: chitin-binding domains (CBD), scavenger receptor cysteine-rich (SRCR) domains, low density lipoprotein receptor cysteine-rich (LDLR-CR) domains, histidine and proline-rich domains, a NGGYQPP-repeat domain and a serine protease domain. Histidine 186-195 Tequila Drosophila melanogaster 21-26 15528859-5 2004 In addition, the feline CD7 protein fused with histidine tag was expressed in 293T cells. Histidine 47-56 CD7 molecule Homo sapiens 24-27 15226312-8 2004 In this way, the structural determinants of regioselectivity in FAT-1 and FAT-2 have been localized to two interdependent regions: a relatively hydrophobic region between the first two histidine boxes and the carboxyl-terminal region. Histidine 185-194 Omega-3 fatty acid desaturase fat-1 Caenorhabditis elegans 64-69 15226312-8 2004 In this way, the structural determinants of regioselectivity in FAT-1 and FAT-2 have been localized to two interdependent regions: a relatively hydrophobic region between the first two histidine boxes and the carboxyl-terminal region. Histidine 185-194 Delta(12) fatty acid desaturase fat-2 Caenorhabditis elegans 74-79 15325241-3 2004 The present study provides experimental evidence that the histidine triad (HIT) domain in aprataxin has enzymatic activity that is negatively regulated by the intramolecular interaction of the N-terminal domain. Histidine 58-67 aprataxin Homo sapiens 90-99 15366949-7 2004 Two such labeling reagents were designed, synthesized, and used to modify both N- and C-terminally His-tagged versions of the enzyme murine dihydrofolate reductase (mDHFR). Histidine 99-102 dihydrofolate reductase Mus musculus 165-170 15336487-7 2004 The 56 kDa MobA was expressed in E. coli as a (6x)His-Tag fusion protein. Histidine 50-53 plasmid mobilization protein Escherichia coli 11-15 15612468-5 2004 RESULTS: The proportion of XRCC1 c.194Arg/Trp + Trp/Trp genotypes in the case group was lower than that of the control group, while there was a higher proportion for XRCC1 C.280Arg/His + His/His in the case group. Histidine 181-184 X-ray repair cross complementing 1 Homo sapiens 27-32 15612468-5 2004 RESULTS: The proportion of XRCC1 c.194Arg/Trp + Trp/Trp genotypes in the case group was lower than that of the control group, while there was a higher proportion for XRCC1 C.280Arg/His + His/His in the case group. Histidine 187-190 X-ray repair cross complementing 1 Homo sapiens 27-32 15612468-5 2004 RESULTS: The proportion of XRCC1 c.194Arg/Trp + Trp/Trp genotypes in the case group was lower than that of the control group, while there was a higher proportion for XRCC1 C.280Arg/His + His/His in the case group. Histidine 187-190 X-ray repair cross complementing 1 Homo sapiens 27-32 15612468-7 2004 CONCLUSION: The risk of BP for subjects carrying XRCC1 c.194Arg/Trp + Trp/Trp genotypes may decrease while for individuals carrying XRCC1 c.280Arg/His + His/His genotypes may increase. Histidine 147-150 X-ray repair cross complementing 1 Homo sapiens 49-54 15612468-7 2004 CONCLUSION: The risk of BP for subjects carrying XRCC1 c.194Arg/Trp + Trp/Trp genotypes may decrease while for individuals carrying XRCC1 c.280Arg/His + His/His genotypes may increase. Histidine 153-156 X-ray repair cross complementing 1 Homo sapiens 49-54 15358233-5 2004 Furthermore, His-p53 and FLAG-XPG, but not PCNA, stimulated the Tg DNA glycosylase/AP lyase activity of GST-NTH1 or NTH1. Histidine 13-16 nth like DNA glycosylase 1 Homo sapiens 116-120 15258613-7 2004 Furthermore, the residues that orient and stabilize the active-site histidine of otubain 2 are different from other cysteine proteases. Histidine 68-77 OTU deubiquitinase, ubiquitin aldehyde binding 2 Homo sapiens 81-90 15273299-6 2004 The reaction PQQ-->PQQH- occurs with Glu 171-CO2- and His 144-Im as the base species in MDH and sGDH, respectively. Histidine 57-60 malate dehydrogenase 2 Homo sapiens 91-94 24815030-6 2014 We then describe single-particle fluorescence imaging experiments in which we follow the effect of these histidine mutations on susceptibility to Hsc70-dependent uncoating. Histidine 105-114 heat shock protein family A (Hsp70) member 8 Homo sapiens 146-151 24819655-5 2014 On the other hand, in the presence of L-histidine or L-arginine, [Eu(pda)2](-) exhibited intense CPL (glum ~ 0.08 for the (5)D0 (7)F1 transition at 0.10 mol dm(-3) of the amino acid), whereas quite weak CPL was observed for [Eu(bda)2](-) under the same conditions (glum < 0.01). Histidine 38-49 hephaestin Homo sapiens 205-208 24467436-9 2014 NAT enzymes act through a catalytic triad of Cys, His and Asp with the architecture of the active site-modulating specificity. Histidine 50-53 bromodomain containing 2 Homo sapiens 0-3 15196988-5 2004 In CYP2A6, the amino acid residues at position 117 and 372 are valine (Val) and arginine (Arg), respectively; whereas in CYP2A13, they are alanine (Ala) and histidine (His). Histidine 157-166 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 3-9 15196988-5 2004 In CYP2A6, the amino acid residues at position 117 and 372 are valine (Val) and arginine (Arg), respectively; whereas in CYP2A13, they are alanine (Ala) and histidine (His). Histidine 157-166 cytochrome P450 family 2 subfamily A member 13 Homo sapiens 121-128 15196988-5 2004 In CYP2A6, the amino acid residues at position 117 and 372 are valine (Val) and arginine (Arg), respectively; whereas in CYP2A13, they are alanine (Ala) and histidine (His). Histidine 168-171 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 3-9 15196988-5 2004 In CYP2A6, the amino acid residues at position 117 and 372 are valine (Val) and arginine (Arg), respectively; whereas in CYP2A13, they are alanine (Ala) and histidine (His). Histidine 168-171 cytochrome P450 family 2 subfamily A member 13 Homo sapiens 121-128 24817736-6 2014 The pathway is initiated by EgtD, a SAM-dependent methyltransferase that catalyzes a trimethylation reaction of histidine to give N(alpha),N(alpha),N(alpha)-trimethylhistidine. Histidine 112-121 THUMP domain containing 2 Homo sapiens 36-67 15189568-5 2004 swi encodes a predicted 68.5-kDa protein that contains N-terminal histidine-rich and threonine-rich domains, a cysteine-rich C-terminal region and two leucine-rich repeats. Histidine 66-75 halfway Drosophila melanogaster 0-3 15169884-5 2004 Mutations of the cysteine or histidine residues in the C2HR motif abolish the interaction of Nizp1 with NSD1 and compromise the ability of Nizp1 to repress transcription. Histidine 29-38 zinc finger protein 496 Homo sapiens 93-98 15169884-5 2004 Mutations of the cysteine or histidine residues in the C2HR motif abolish the interaction of Nizp1 with NSD1 and compromise the ability of Nizp1 to repress transcription. Histidine 29-38 zinc finger protein 496 Homo sapiens 139-144 24354269-5 2014 We found that trivalent conjugates that included both the targeting sequence and several histidine residues were substantially more effective than conjugates containing only the bombesin or histidine moieties. Histidine 89-98 gastrin releasing peptide Homo sapiens 178-186 24213606-5 2013 The co-existence of carnosine or His inhibited the expression of GADD34, p8, and Arc, although they did not influence the expression of the metal-related genes. Histidine 33-36 protein phosphatase 1, regulatory subunit 15A Mus musculus 65-71 24026233-3 2013 In this study, the full-length mouse alpha-CP2 gene was expressed in an insoluble form with an N-terminal histidine tag in Escherichia coli and purified for homogeneity using affinity column chromatography. Histidine 106-115 poly(rC) binding protein 2 Mus musculus 37-46 23706761-6 2013 An interesting coordination mode has been proposed for the IRT1-Zn(2+) complex, in which imidazoles from two histidines (His-96 and His-116), a cysteine thiolate (Cys-109) and one of a glutamic acid carboxyl group are involved. Histidine 109-119 iron-regulated transporter 1 Arabidopsis thaliana 59-63 23706761-6 2013 An interesting coordination mode has been proposed for the IRT1-Zn(2+) complex, in which imidazoles from two histidines (His-96 and His-116), a cysteine thiolate (Cys-109) and one of a glutamic acid carboxyl group are involved. Histidine 121-124 iron-regulated transporter 1 Arabidopsis thaliana 59-63 23706761-6 2013 An interesting coordination mode has been proposed for the IRT1-Zn(2+) complex, in which imidazoles from two histidines (His-96 and His-116), a cysteine thiolate (Cys-109) and one of a glutamic acid carboxyl group are involved. Histidine 132-135 iron-regulated transporter 1 Arabidopsis thaliana 59-63 23916489-2 2013 In this study, we successfully partially purified His-tagged tetherin with a glycophosphatidylinositol deletion (delGPI) and His-tagged full-length Vpu from transiently transfected 293T cells using affinity chromatography. Histidine 50-53 bone marrow stromal cell antigen 2 Homo sapiens 61-69 23733202-2 2013 XRCC1 codon 280 polymorphism is an Arg-His change in the XRCC1 gene. Histidine 39-42 X-ray repair cross complementing 1 Homo sapiens 57-62 15020597-1 2004 Neuroglobin, recently discovered in the brain and in the retina of vertebrates, belongs to the class of hexacoordinate globins, in which the distal histidine coordinates the iron center in both the Fe(II) and Fe(III) forms. Histidine 148-157 neuroglobin Homo sapiens 0-11 15113176-3 2004 pH values calculated from the (31)P NMR spectra using the chemical shifts of the C-6 line of histidine in the (1)H spectra and the chemical shifts of inorganic phosphate in the (31)P spectra confirmed the different muscle glycogen status in the tissues. Histidine 93-102 LOW QUALITY PROTEIN: complement component C6 Oryctolagus cuniculus 81-84 15604682-9 2004 Both (His)6-ACBP4 and (His)6-ACBP5 bind [14C]oleoyl-CoA with high affinity, [14C]palmitoyl-CoA with lower affinity and did not bind [14C]arachidonyl-CoA. Histidine 23-26 acyl-CoA binding protein 5 Arabidopsis thaliana 29-34 15066755-1 2004 GALA is a 30 amino acid synthetic peptide with a glutamic acid-alanine-leucine-alanine (EALA) repeat that also contains a histidine and tryptophan residue as spectroscopic probes. Histidine 122-131 galactosidase alpha Homo sapiens 0-4 23770703-6 2013 The overall fold of (BACCR)NAT3 and the geometry of its Cys-His-Glu catalytic triad are similar to those present in functional NATs. Histidine 60-63 N-alpha-acetyltransferase 20, NatB catalytic subunit Homo sapiens 27-31 23770703-9 2013 Computational analysis identified differences in residue packing and steric constraints in the active site of (BACCR)NAT3 that allow it to accommodate a Cys-His-Glu triad. Histidine 157-160 N-alpha-acetyltransferase 20, NatB catalytic subunit Homo sapiens 117-121 23831028-4 2013 The crystal structure of Dido3 PHD in complex with H3K4me3 reveals an atypical aromatic-cage-like binding site that contains a histidine residue. Histidine 127-136 death inducer-obliterator 1 Homo sapiens 25-30 23589456-6 2013 HIS3, an essential enzyme for histidine biosynthesis, was placed exclusively under a GAL promoter, which is induced by galactose and strongly repressed in glucose. Histidine 30-39 imidazoleglycerol-phosphate dehydratase HIS3 Saccharomyces cerevisiae S288C 0-4 15073296-6 2004 DevR-DevS was thus established as a typical two-component regulatory system based on His-to-Asp phosphoryl transfer. Histidine 85-88 two component transcriptional regulator DevR Mycobacterium tuberculosis H37Rv 0-4 14672929-12 2004 The simulation offers insight into why Sdh4p Cys-78 may be serving as the second axial ligand for the heme instead of a histidine residue. Histidine 120-129 succinate dehydrogenase membrane anchor subunit SDH4 Saccharomyces cerevisiae S288C 39-44 14672943-0 2004 Identification of crucial histidines for heme binding in the N-terminal domain of the heme-regulated eIF2alpha kinase. Histidine 26-36 eukaryotic translation initiation factor 2A Homo sapiens 101-110 14759599-11 2004 Protonation of His-64 in Mb enhances HN3 binding due to a gating mechanism while protonation of His-52 in CcP decreases the affinity for HN3 due to loss of base-assisted association of the ligand to the heme iron. Histidine 96-99 cytochrome-c peroxidase Saccharomyces cerevisiae S288C 106-109 17191848-1 2004 Although both the structures and the reactions of histidine and phenylalanine ammonia lyases (HAL and PAL) are very similar, the former shows a primary kinetic deuterium (D) isotope effect, while the latter does not. Histidine 50-59 histidine ammonia-lyase Homo sapiens 94-97 15000850-2 2004 Hybridomas were screened by indirect enzyme-linked immunosorbent assay (ELISA) using either purified 6 x His-ZNRD1fusion protein or purified 6 x His-OS-9 fusion protein as a control. Histidine 105-108 RNA polymerase I subunit H Homo sapiens 109-114 23589456-10 2013 The new regulation of HIS3 tuned its expression according to histidine requirements with or without these significant mutations, indicating that additional factors participated in this regulation and that the regulatory network could reorganize in multiple ways to accommodate different mutations. Histidine 61-70 imidazoleglycerol-phosphate dehydratase HIS3 Saccharomyces cerevisiae S288C 22-26 23514341-2 2013 Intensive catalytic activity in solvolysis of sterically hindered Z-Aib-Aib-ONp under ambient conditions was observed for structures bearing the catalytic triad as well as for structures with the peptide fragment shortened to a dipeptide or even a single Ser, Glu or His residue, but not for structures bearing alanine or phenylalanine residues. Histidine 267-270 ANIB1 Homo sapiens 68-71 22896902-0 2004 Evidence for the presence of a critical histidine residue at the active site in glyceraldehyde-3-phosphate dehydrogenase of Ehrlich ascites carcinoma cells. Histidine 40-49 glyceraldehyde-3-phosphate dehydrogenase Mus musculus 80-120 22896902-5 2004 Statistical analysis of the residual enzyme activity and the extent of modification indicated modification of one essential histidine residue to be responsible for loss of the catalytic activity of EAC cell GA3PD. Histidine 124-133 glyceraldehyde-3-phosphate dehydrogenase Mus musculus 207-212 14580238-1 2004 We have introduced a pseudoachondroplasia-associated mutation (His(587)-->Arg) into the C-terminal collagen-binding domain of COMP (cartilage oligomeric matrix protein) and recombinantly expressed the full-length protein as well as truncated fragments in HEK-293 cells. Histidine 63-66 cartilage oligomeric matrix protein Homo sapiens 129-133 14580238-1 2004 We have introduced a pseudoachondroplasia-associated mutation (His(587)-->Arg) into the C-terminal collagen-binding domain of COMP (cartilage oligomeric matrix protein) and recombinantly expressed the full-length protein as well as truncated fragments in HEK-293 cells. Histidine 63-66 cartilage oligomeric matrix protein Homo sapiens 135-170 14580238-6 2004 Also a COMP His(587)-->Arg fragment encompassing the calcium-binding repeats and the C-terminal collagen-binding domain bound collagens equally well as the corresponding wild-type protein. Histidine 12-15 cartilage oligomeric matrix protein Homo sapiens 7-11 14711628-6 2004 The OmpT variants with leucine and histidine at position 97 were useful in releasing human adrenocorticotropic hormone (1-24) (serine at the N terminus) and human calcitonin precursor (cysteine at the N terminus), respectively, from fusion proteins. Histidine 35-44 outer membrane protease Escherichia coli 4-8 23514341-2 2013 Intensive catalytic activity in solvolysis of sterically hindered Z-Aib-Aib-ONp under ambient conditions was observed for structures bearing the catalytic triad as well as for structures with the peptide fragment shortened to a dipeptide or even a single Ser, Glu or His residue, but not for structures bearing alanine or phenylalanine residues. Histidine 267-270 ANIB1 Homo sapiens 72-75 23652332-5 2013 Here, we reported that the His-rich domain of selenoprotein P (SelP-H) and the Sec-to-Cys mutant selenoprotein M (SelM") are capable of binding transition metal ions and modulating the Zn(2+)-mediated Abeta aggregation, ROS production and neurotoxicity. Histidine 27-30 selenoprotein M Homo sapiens 114-119 23717386-4 2013 The structure of the soluble domain of NAF-1 shows that it forms a homodimer with each protomer containing a [2Fe-2S] cluster bound by 3 Cys and one His. Histidine 149-152 CDGSH iron sulfur domain 2 Homo sapiens 39-44 15036292-1 2004 Neuroglobin displays a hexacoordination His-Fe-His in the absence of external ligands such as oxygen. Histidine 40-44 neuroglobin Homo sapiens 0-11 15036292-7 2004 Mutation of specific cysteines, or reduction to break the S-S bond, led to a large decrease in the observed oxygen affinity of human neuroglobin, mainly due to a decrease in the histidine dissociation rate. Histidine 178-187 neuroglobin Homo sapiens 133-144 23031341-11 2013 Four different AsaP1 mutants (AsaP1(E294A), AsaP1(E294Q), AsaP1(Y309A), and AsaP1(Y309F)) were successfully constructed by one step site directed mutagenesis, expressed in E. coli BL21 C43 as pre-pro-proteins and purified by His-tag affinity chromatography and gel filtration. Histidine 225-228 LOW QUALITY PROTEIN: arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1a Salmo salar 15-20 14686842-2 2003 The syn coordination of histidine residues at the active sites of several carboxylate-rich non-heme diiron enzymes has been difficult to reproduce with small molecule model compounds. Histidine 24-33 synemin Homo sapiens 4-7 14530264-1 2003 Neuroglobin and cytoglobin reversibly bind oxygen in competition with the distal histidine, and the observed oxygen affinity therefore depends on the properties of both ligands. Histidine 81-90 neuroglobin Homo sapiens 0-11 23795473-5 2013 Deletion of the transcriptional regulator gene purR increased the biomass produced and maintained the level of histidine production per cell under the fermentation conditions used. Histidine 111-120 DNA-binding transcriptional repressor PurR Escherichia coli str. K-12 substr. MG1655 47-51 22967951-6 2013 MsrA adsorbs on the hydrophobic carbon electrode surface preferentially through the three hydrophobic domains, C1, C2 and C3, which contain the tyrosine, tryptophan and histidine residues, and tryptophan exists only in these regions, and undergo electrochemical oxidation. Histidine 169-178 methionine sulfoxide reductase A Homo sapiens 0-4 23097400-11 2013 Arginine, His, and Leu are examples of AA that can promote insulin secretion, and in turn, insulin can increase fetal IGF-I concentrations. Histidine 10-13 LOC105613195 Ovis aries 59-66 14645567-3 2003 The ts138 mutant possessed a change of G4303 to C, predicting an Ala68-to-Gly alteration that altered a conserved His-Ala-Val tripeptide in the ancient (pre-eukaryotic), "X" or histone 2A phosphoesterase-like macrodomain that in SIN encompasses nsP3 residues 1 to 161 and whose role is unknown. Histidine 114-117 SH2 domain containing 3C Homo sapiens 245-249 14673502-6 2003 The results showed that the neural-inhibiting activity of xGATA-1b, but not hematopoiesis-inducing activity, was aborted because of deletion of Ser(168) and His(169) or point mutation of T(359)-->A. Histidine 157-160 GATA binding protein 1 S homeolog Xenopus laevis 58-66 14673502-7 2003 So it is demonstrated for the first time that Ser(168) and His(169) or Thr(359)in xGATA-1b may be one of the structural basis for explanting the different function between xGATA-1b and xGATA-1a. Histidine 59-62 GATA binding protein 1 S homeolog Xenopus laevis 82-90 14673502-7 2003 So it is demonstrated for the first time that Ser(168) and His(169) or Thr(359)in xGATA-1b may be one of the structural basis for explanting the different function between xGATA-1b and xGATA-1a. Histidine 59-62 GATA binding protein 1 S homeolog Xenopus laevis 172-180 14584947-3 2003 To probe the receptor active conformation of the pharmacophore His-Phe-Arg-Trp in gamma-MSH, two different series of gamma-MSH analogues have been designed and synthesized and their biological activities determined at hMC3R, hMC4R, and hMC5R. Histidine 63-66 melanocortin 4 receptor Homo sapiens 225-230 14584947-3 2003 To probe the receptor active conformation of the pharmacophore His-Phe-Arg-Trp in gamma-MSH, two different series of gamma-MSH analogues have been designed and synthesized and their biological activities determined at hMC3R, hMC4R, and hMC5R. Histidine 63-66 melanocortin 5 receptor Homo sapiens 236-241 12959987-10 2003 In conclusion, L-His can potentiate both GLP-1R- and CaSR-activated signaling pathways, and these effects may play a role in the potentiation of glucose-induced insulin secretion in response to meals containing protein in addition to carbohydrates and fat. Histidine 15-20 glucagon-like peptide 1 receptor Rattus norvegicus 41-48 12959987-10 2003 In conclusion, L-His can potentiate both GLP-1R- and CaSR-activated signaling pathways, and these effects may play a role in the potentiation of glucose-induced insulin secretion in response to meals containing protein in addition to carbohydrates and fat. Histidine 15-20 calcium-sensing receptor Rattus norvegicus 53-57 12837132-8 2003 Taken together, the selectivity of Abz-HPGGPQ-EDN2ph to cathepsin K primarily depends on the S2 and S2" subsite specificities of cathepsin K and the ionization state of histidine at P3. Histidine 169-178 endothelin 2 Homo sapiens 46-50 14516201-4 2003 Strikingly, the GXIIB sPLA(2) has a mutation in the active site, replacing the canonical histidine by a leucine, suggesting that this sPLA(2) is catalytically inactive. Histidine 89-98 phospholipase A2 group XIIB Homo sapiens 16-21 14578150-7 2003 For XRCC1 codon 280 genotypes of Arg/His and His/His compared with the Arg/Arg genotype, the OR was 0.64 (95% CI, 0.43-0.96). Histidine 45-48 X-ray repair cross complementing 1 Homo sapiens 4-9 14578150-7 2003 For XRCC1 codon 280 genotypes of Arg/His and His/His compared with the Arg/Arg genotype, the OR was 0.64 (95% CI, 0.43-0.96). Histidine 45-48 X-ray repair cross complementing 1 Homo sapiens 4-9 14550642-5 2003 For efficient expression and purification, we cloned the cDNAs corresponding to proteolytically processed forms of LOX (LOX-p) and LOXL (LOXL-p1 and LOXL-p2) into a bacterial expression vector pET21a with six continuous histidine codons attached to the 3" of the gene. Histidine 220-229 lysyl oxidase Homo sapiens 115-118 12963343-3 2003 The expression of N-terminal His(6)-tagged Pwo dUTPase was performed in E. coli BL21(DE3)pLysS and E. coli Rosetta(DE3)pLysS strain that contains plasmid encoding additional copies of rare E. coli tRNAs. Histidine 29-32 Deoxyuridine triphosphatase Drosophila melanogaster 47-54 12764157-1 2003 We mutated residues Met345 and Thr349 in the rat gamma-aminobutyric acid transporter-1 (GAT-1) to histidines (M345H and T349H). Histidine 98-108 solute carrier family 6 member 12 Rattus norvegicus 49-93 23220592-5 2013 The stabilities of ABH-am and BAH-am complexes are intermediate between those of strong His-3 peptides but these complexes are still able to saturate the coordination sphere of the Cu(II) ion at neutral pH. Histidine 88-91 alkB homolog 1, histone H2A dioxygenase Homo sapiens 19-22 23291761-2 2013 Here we identified common amino acid sequences predicted from coding exons of the FGF4 gene in five pigs of two breeds, and HispFGF4, a 6x histidine-tagged porcine FGF4, was produced in Escherichia coli. Histidine 139-148 fibroblast growth factor 4 Sus scrofa 128-132 23653868-6 2013 The most informative results were obtained with the exon 4 flanking primers and the Cac8I restriction enzyme, which generated a 253 bp product that carries the ACVR1 617G>A mutation, which causes an amino acid substitution of histidine for arginine at position 206 of the glycine-serine (GS) domain, and its mutation results in the dysregulation of bone morphogenetic protein (BMP) signalling that causes FOP. Histidine 229-238 activin A receptor type 1 Homo sapiens 160-165 23134726-2 2012 We used single histidine (H) substitutions of these charged residues in the Na(v)1.4 channel to probe the positions of the S4 segments at hyperpolarized potentials. Histidine 15-24 immunoglobulin lambda variable 2-14 Homo sapiens 76-84 22957700-11 2012 Magnetic circular dichroism, resonance Raman, and electron paramagnetic resonance spectroscopic data on the ferric, ferrous, and ferrous-CO complexes of GAPDH showed that the heme is bis-ligated with His as the proximal ligand. Histidine 200-203 glyceraldehyde-3-phosphate dehydrogenase Oryctolagus cuniculus 153-158 12874010-7 2003 Re(I)-BBN conjugates were prepared by the reaction of [Re(Br)(3)(CO)(3)](2-) and Dpr-Ser-Ser-Ser-Gln-Trp-Ala-Val-Gly-His-Leu-Met-(NH(2)) with gentle heating. Histidine 117-120 gastrin releasing peptide Homo sapiens 6-9 12836044-4 2003 The signal is then transferred via histidine-containing phosphotransfer factors, AHPs, to transcription-factor-type response regulators, such as ARR1, which execute the signal-dependent transactivation of primary cytokinin-responsive genes, including those for other types of response regulator. Histidine 35-44 response regulator 1 Arabidopsis thaliana 145-149 12733060-4 2003 In this work, we demonstrated that the NFO3 gene is identical to OLE1 and that the nfo3-1 mutation (renamed ole1-101) alters arginine-346, in the vicinity of the conserved histidine-rich motif essential for the catalytic function of the Ole1 protein, to lysine. Histidine 172-181 stearoyl-CoA 9-desaturase Saccharomyces cerevisiae S288C 108-112 12748294-0 2003 The histidine triad protein Hint is not required for murine development or Cdk7 function. Histidine 4-13 histidine triad nucleotide binding protein 1 Mus musculus 28-32 12748294-1 2003 The histidine triad (HIT) protein Hint has been found to associate with mammalian Cdk7, as well as to interact both physically and genetically with the budding yeast Cdk7 homologue Kin28. Histidine 4-13 histidine triad nucleotide binding protein 1 Mus musculus 34-38 12719214-6 2003 Certain residues (namely Glu-72, His-88, His-90, Glu-92, and Tyr-116), play an important role in the binding process, as seen by the considerable pK(1/2) change of these residues upon dimer formation. Histidine 33-36 prokineticin 1 Homo sapiens 146-152 12719214-6 2003 Certain residues (namely Glu-72, His-88, His-90, Glu-92, and Tyr-116), play an important role in the binding process, as seen by the considerable pK(1/2) change of these residues upon dimer formation. Histidine 41-44 prokineticin 1 Homo sapiens 146-152 12719228-5 2003 Treatment of the hSlo1 channel with the histidine modifying agent diethyl pyrocarbonate also enhanced the hSlo1 currents and greatly diminished the internal pH sensitivity, suggesting that diethyl pyrocarbonate and low pH may work on the same effector mechanism. Histidine 40-49 potassium calcium-activated channel subfamily M alpha 1 Homo sapiens 17-22 12719228-5 2003 Treatment of the hSlo1 channel with the histidine modifying agent diethyl pyrocarbonate also enhanced the hSlo1 currents and greatly diminished the internal pH sensitivity, suggesting that diethyl pyrocarbonate and low pH may work on the same effector mechanism. Histidine 40-49 potassium calcium-activated channel subfamily M alpha 1 Homo sapiens 106-111 22740564-11 2012 Rapid and complete disassembly of the T-cell surface-bound A02/CMV Histamer followed by the subsequent dissociation of the pMHC monomers from CD8(+) CTL receptors was achieved using 100 mM L-histidine. Histidine 189-200 CD8a molecule Homo sapiens 142-145 22657152-3 2012 Inactivation of ACL by treatment with diethylpyrocarbonate suggested the catalytic role of an active site histidine (i.e., His760), which was proposed to form a phosphohistidine species during catalysis. Histidine 106-115 ATP citrate lyase Homo sapiens 16-19 22657152-5 2012 Mutagenesis of His760 to an alanine results in inactivation of the biosynthetic reaction of ACL, in good agreement with the involvement of a catalytic histidine. Histidine 151-160 ATP citrate lyase Homo sapiens 92-95 22506810-1 2012 The Arabidopsis thaliana At1g68290 gene encoding an endonuclease was isolated and designated ENDO2, which was cloned into a binary vector to overexpress ENDO2 with a C-terminal 6 x His-tag in A. thaliana. Histidine 181-184 endonuclease 2 Arabidopsis thaliana 93-98 12814263-2 2003 A hexa-histidine tag was also added to the C-terminus of RBP for ease of purification. Histidine 7-16 retinol binding protein 4 Homo sapiens 57-60 12814271-3 2003 Cu(II)-IMAC was found to be highly selective for histidine containing peptides; moreover, a low degree of nonspecific selection was observed. Histidine 49-58 C-C motif chemokine ligand 26 Homo sapiens 0-11 12766799-3 2003 For example, histidine-168 and tyrosine-332 equivalent to positions 170 and 333 in other mammalian GHRs, which were considered to be necessary for the dimerization of GHR and the specific GH-stimulated functions respectively, were replaced by tyrosine and serine in gpGHR. Histidine 13-22 growth hormone receptor Homo sapiens 99-102 22506810-1 2012 The Arabidopsis thaliana At1g68290 gene encoding an endonuclease was isolated and designated ENDO2, which was cloned into a binary vector to overexpress ENDO2 with a C-terminal 6 x His-tag in A. thaliana. Histidine 181-184 endonuclease 2 Arabidopsis thaliana 153-158 22437839-8 2012 The glutamate-histidine substitution prevents a 3-ketosteroid from penetrating the active site so that hydride transfer is directed toward the C3 carbonyl group rather than the Delta(4)-double bond and confers 3beta-HSD activity on the 5beta-reductase. Histidine 14-23 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 210-219 22391343-3 2012 The mutation (CAT CGT), which has occurred at codon 151, at nucleotide position 524, implies an amino acidic change from Histidine to Arginine. Histidine 122-131 UDP glycosyltransferase 8 Homo sapiens 19-22 22318647-9 2012 l-His > 5"-GMP > 5"-IMP > Ino. Histidine 0-5 5'-nucleotidase, cytosolic II Homo sapiens 14-17 12684055-4 2003 By site-directed mutagenesis the second cysteine residue of the -CysGlyHisCys- motif in the thioredoxin domain of the enzyme protein was found to be the active site of the transamidation reaction and chemical modification of histidine in their motif blocked TGase activity. Histidine 225-234 Thioredoxin Caenorhabditis elegans 92-103 12686130-3 2003 Histidine and phenylalanine ammonia-lyases (HAL and PAL) possess a catalytically essential electrophilic group which has been believed to be dehydroalanine for 30 years. Histidine 0-9 histidine ammonia-lyase Homo sapiens 44-47 12654781-8 2003 Recombinant His-tagged Ecgp blocked E. coli invasion efficiently by binding directly to the bacteria. Histidine 12-15 heat shock protein 90 beta family member 1 Homo sapiens 23-27 12643901-3 2003 The SAR of the amino acid indicates that the carboxylic acid is required for inhibition and that L-histidine is the most favored amino acid. Histidine 97-108 sarcosine dehydrogenase Homo sapiens 4-7 12820376-1 2003 BACKGROUND: The intestinal mitosis-inhibiting peptide pyroglu-His-GlyOH (pEHG), inhibits normal intestinal epithelial cells and the human colon adenocarcinoma cell line HT-29 and increases the expression of c-fos (1). Histidine 62-65 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 207-212 12631327-4 2003 The more efficient putative carrier, AtmBAC1, was expressed in E. coli, purified, and reconstituted into phospholipid vesicles, where it transported the basic l-amino acids arginine, lysine, ornithine and histidine (in order of decreasing affinity). Histidine 205-214 Mitochondrial substrate carrier family protein Arabidopsis thaliana 37-44 12631327-5 2003 AtmBAC1 recognized l-histidine whereas both yeast Ort1p and the mammalian ortholog ORNT1p do not. Histidine 19-30 Mitochondrial substrate carrier family protein Arabidopsis thaliana 0-7 12486123-1 2003 Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta. Histidine 75-78 cytidine/uridine monophosphate kinase 1 Bos taurus 21-25 12486123-11 2003 We conclude that NDPK B forms complexes with Gbetagamma dimers and contributes to G protein activation by increasing the high energetic phosphate transfer onto GDP via intermediately phosphorylated His-266 in Gbeta(1) subunits. Histidine 198-201 cytidine/uridine monophosphate kinase 1 Bos taurus 17-21 12501240-9 2003 Individual mutation of His-64, His-228, or His-352 in GIRK4 abolished or greatly diminished the inhibition in homomeric GIRK4. Histidine 23-26 potassium inwardly rectifying channel subfamily J member 5 Homo sapiens 120-125 12501240-9 2003 Individual mutation of His-64, His-228, or His-352 in GIRK4 abolished or greatly diminished the inhibition in homomeric GIRK4. Histidine 31-34 potassium inwardly rectifying channel subfamily J member 5 Homo sapiens 54-59 12501240-9 2003 Individual mutation of His-64, His-228, or His-352 in GIRK4 abolished or greatly diminished the inhibition in homomeric GIRK4. Histidine 31-34 potassium inwardly rectifying channel subfamily J member 5 Homo sapiens 120-125 12501240-9 2003 Individual mutation of His-64, His-228, or His-352 in GIRK4 abolished or greatly diminished the inhibition in homomeric GIRK4. Histidine 31-34 potassium inwardly rectifying channel subfamily J member 5 Homo sapiens 54-59 12501240-9 2003 Individual mutation of His-64, His-228, or His-352 in GIRK4 abolished or greatly diminished the inhibition in homomeric GIRK4. Histidine 31-34 potassium inwardly rectifying channel subfamily J member 5 Homo sapiens 120-125 12501240-10 2003 Mutations of any of these histidine residues in GIRK4 or their counterparts in GIRK1 were sufficient to eliminate the pH(i) sensitivity of the heteromeric GIRK1/GIRK4 channels. Histidine 26-35 potassium inwardly rectifying channel subfamily J member 5 Homo sapiens 48-53 12501240-10 2003 Mutations of any of these histidine residues in GIRK4 or their counterparts in GIRK1 were sufficient to eliminate the pH(i) sensitivity of the heteromeric GIRK1/GIRK4 channels. Histidine 26-35 potassium inwardly rectifying channel subfamily J member 5 Homo sapiens 161-166 12471029-4 2003 Ribonuclease protection assays revealed that one of these splice variants, RyR3 (AS-8a), which lacks a 29-amino acid fragment (His(4406)-Lys(4434)) encompassing a predicted transmembrane helix, was highly expressed in smooth muscle tissues, but not in skeletal muscle, the heart, or the brain. Histidine 127-130 ryanodine receptor 3 Homo sapiens 75-79 12589497-6 2003 To obtain the methylmalonyl-CoA mutase which was required as a reagent for the assay, an Escherichia coli strain was constructed that expressed high levels of this enzyme as a fusion protein with an 8x histidine tag. Histidine 202-211 methylmalonyl-CoA mutase Homo sapiens 14-38 12561067-6 2003 39.5% (15/38) of point mutations were CGT (Arg) to CAT (His) mutation at codon-273 of exon-8. Histidine 56-59 UDP glycosyltransferase 8 Homo sapiens 38-41 12534280-8 2003 In the high-spin form of NP2, the proximal histidine plane is shown to be oriented 135 degrees clockwise from the heme N(II)-Fe-N(IV) axis, again for the B heme orientation. Histidine 43-52 neuropilin 2 Homo sapiens 25-28 12564680-5 2003 Cu(II)-IMAC selection of histidine-containing peptides from standard peptide mixtures and protein digests followed by reversed-phase chromatography of the selected peptides was demonstrated in the electrochromatography mode. Histidine 25-34 C-C motif chemokine ligand 26 Homo sapiens 0-11 12409304-6 2003 To identify the Zn(2+) binding site responsible for the enhancement of agonist affinity in the beta(2)AR, we mutated histidines located in hydrophilic sequences bridging the seven transmembrane domains. Histidine 117-127 adrenoceptor beta 2 Homo sapiens 95-104 12532276-0 2003 Two histidine residues in the juxta-membrane cytoplasmic domain of Na+/H+ exchanger isoform 3 (NHE3) determine the set point. Histidine 4-13 solute carrier family 9 member A3 Homo sapiens 67-93 12532276-0 2003 Two histidine residues in the juxta-membrane cytoplasmic domain of Na+/H+ exchanger isoform 3 (NHE3) determine the set point. Histidine 4-13 solute carrier family 9 member A3 Homo sapiens 95-99 12532276-2 2003 In the present study, the function of three highly conserved histidines in the juxtamembrane cytoplasmic domain of NHE3 was studied. Histidine 61-71 solute carrier family 9 member A3 Homo sapiens 115-119 12532276-5 2003 However, the mutation in His-475 and His-499 significantly lowered NHE3 transport activity, whereas the mutation in H485 showed no apparent effect. Histidine 25-28 solute carrier family 9 member A3 Homo sapiens 67-71 12532276-5 2003 However, the mutation in His-475 and His-499 significantly lowered NHE3 transport activity, whereas the mutation in H485 showed no apparent effect. Histidine 37-40 solute carrier family 9 member A3 Homo sapiens 67-71 12532276-7 2003 The changes in set point by the mutations were further shifted to more acidic values by ATP depletion, indicating that the mechanism by which the mutations on the histidine residues altered the NHE3 set point differs from that caused by ATP depletion. Histidine 163-172 solute carrier family 9 member A3 Homo sapiens 194-198 12432067-7 2002 In actin pull-down assays, the apparent K(d) of bacterially expressed his-tagged lasp-1 binding to F-actin was 2 micro M with a saturation stoichiometry of approximately 1:7. Histidine 70-73 LIM and SH3 protein 1 Homo sapiens 81-87 12444763-0 2002 Providing a chemical basis toward understanding the histidine base-on motif of methylcobalamin-dependent methionine synthase: an improved purification of methylcobinamide, plus thermodynamic studies of methylcobinamide binding exogenous imidazole and pyridine bases. Histidine 52-61 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 105-124 12553726-6 2002 The data give strong evidence that the unique C-tail of S100A9 containing the three consecutive histidine residues (His103-His105) represents the region to which the fatty acid carboxy-group is bound to the protein complex. Histidine 96-105 S100 calcium binding protein A9 Homo sapiens 56-62 12524347-2 2002 We show that SU(VAR)3-9 is a chromatin-associated protein and identify the large multicopy histone gene cluster (HIS-C) as one of its target loci. Histidine 113-116 Suppressor of variegation 3-9 Drosophila melanogaster 13-23 12524347-3 2002 The organization of nucleosomes over the entire HIS-C region is altered in Su(var)3-9 mutants and there is a concomitant increase in expression of the histone genes. Histidine 48-51 Suppressor of variegation 3-9 Drosophila melanogaster 75-85 12524347-4 2002 SU(VAR)3-9 is a histone H3 methyltransferase and, using chromatin immunoprecipitation, we show that SU(VAR)3-9 is present at the HIS-C locus and that the histone H3 at the HIS-C locus is methylated. Histidine 129-132 Suppressor of variegation 3-9 Drosophila melanogaster 0-10 12524347-4 2002 SU(VAR)3-9 is a histone H3 methyltransferase and, using chromatin immunoprecipitation, we show that SU(VAR)3-9 is present at the HIS-C locus and that the histone H3 at the HIS-C locus is methylated. Histidine 129-132 Suppressor of variegation 3-9 Drosophila melanogaster 100-110 12524347-4 2002 SU(VAR)3-9 is a histone H3 methyltransferase and, using chromatin immunoprecipitation, we show that SU(VAR)3-9 is present at the HIS-C locus and that the histone H3 at the HIS-C locus is methylated. Histidine 172-175 Suppressor of variegation 3-9 Drosophila melanogaster 0-10 12524347-4 2002 SU(VAR)3-9 is a histone H3 methyltransferase and, using chromatin immunoprecipitation, we show that SU(VAR)3-9 is present at the HIS-C locus and that the histone H3 at the HIS-C locus is methylated. Histidine 172-175 Suppressor of variegation 3-9 Drosophila melanogaster 100-110 12524347-5 2002 We propose that SU(VAR)3-9 is involved in packaging HIS-C into a distinct chromatin domain that has some of the characteristics of beta-heterochromatin. Histidine 52-55 Suppressor of variegation 3-9 Drosophila melanogaster 16-26 12589073-6 2002 The Arabidopsis CRE1 histidine kinase and its related proteins AHK2 and AHK3 perceive cytokinins in the environment and transduce a signal, presumably through the AHP bridge components that carry the histidine-containing phosphotransfer (HPt) domain, to the ARR1 response regulator that transcriptionally activates genes immediately responsive to cytokinins. Histidine 21-30 histidine kinase 2 Arabidopsis thaliana 63-67 12589073-6 2002 The Arabidopsis CRE1 histidine kinase and its related proteins AHK2 and AHK3 perceive cytokinins in the environment and transduce a signal, presumably through the AHP bridge components that carry the histidine-containing phosphotransfer (HPt) domain, to the ARR1 response regulator that transcriptionally activates genes immediately responsive to cytokinins. Histidine 21-30 response regulator 1 Arabidopsis thaliana 258-262 12457963-8 2002 A cluster of eight histidine residues was found in proximity to the last transmembrane domain of Cyno-EBV LMP1 and was exploited as a natural protein tag in expression studies. Histidine 19-28 PDZ and LIM domain 7 Homo sapiens 106-110 12213808-0 2002 N-terminal sequence and distal histidine residues are responsible for pH-regulated cytoplasmic membrane binding of human AMP deaminase isoform E. Mammalian AMP deaminase 3 (AMPD3) enzymes reportedly bind to intracellular membranes, plasma lipid vesicles, and artificial lipid bilayers with associated alterations in enzyme conformation and function. Histidine 31-40 adenosine monophosphate deaminase 3 Homo sapiens 156-171 12213808-0 2002 N-terminal sequence and distal histidine residues are responsible for pH-regulated cytoplasmic membrane binding of human AMP deaminase isoform E. Mammalian AMP deaminase 3 (AMPD3) enzymes reportedly bind to intracellular membranes, plasma lipid vesicles, and artificial lipid bilayers with associated alterations in enzyme conformation and function. Histidine 31-40 adenosine monophosphate deaminase 3 Homo sapiens 173-178 12213808-8 2002 Finally, AMPD1 and a series of N-truncated AMPD3 enzymes are used to show that these behaviors are specific to isoform E and require up to 48 N-terminal amino acids, even though this stretch of sequence contains no histidine residues. Histidine 215-224 adenosine monophosphate deaminase 3 Homo sapiens 43-48 12194980-7 2002 Studies with recombinant V5-His-tagged FLRG protein confirm a direct interaction between mature myostatin and FLRG. Histidine 28-31 follistatin-like 3 Mus musculus 39-43 12194980-7 2002 Studies with recombinant V5-His-tagged FLRG protein confirm a direct interaction between mature myostatin and FLRG. Histidine 28-31 follistatin-like 3 Mus musculus 110-114 12459266-5 2002 The presence of this motif, together with a conserved order and spacing of the Ser, Asp, and His residues that form the catalytic triad in DPP IV, places DPP9 in the "DPP IV gene family". Histidine 93-96 dipeptidyl peptidase 9 Homo sapiens 154-158 12145281-12 2002 In contrast, two conserved histidines were important for thioredoxin-dependent activity, but were not involved in zinc binding. Histidine 27-37 uncharacterized protein Drosophila melanogaster 57-68 12145299-3 2002 Pho2 + Swi5 activates HO, Pho2 + Pho4 activates PHO5, and Pho2 + Bas1 activates genes in the purine and histidine biosynthesis pathways. Histidine 104-113 DNA-binding transcription factor SWI5 Saccharomyces cerevisiae S288C 7-11 12145299-3 2002 Pho2 + Swi5 activates HO, Pho2 + Pho4 activates PHO5, and Pho2 + Bas1 activates genes in the purine and histidine biosynthesis pathways. Histidine 104-113 phosphate-sensing transcription factor PHO4 Saccharomyces cerevisiae S288C 33-37 22509914-3 2012 The present study describes the production of a human anti-GPA monoclonal antibody and its purification using a pseudo-bioaffinity L-histidine-convective interaction media (CIM) monolithic column. Histidine 131-142 glycophorin A Mus musculus 59-62 21720759-10 2012 Western blot analysis indicated that His-tagged yak OPN protein expressed in E. coli could be recognized not only by an anti-His-tag antibody but also by an anti-human OPN antibody. Histidine 37-40 secreted phosphoprotein 1 Bos taurus 52-55 21720759-10 2012 Western blot analysis indicated that His-tagged yak OPN protein expressed in E. coli could be recognized not only by an anti-His-tag antibody but also by an anti-human OPN antibody. Histidine 37-40 secreted phosphoprotein 1 Bos taurus 168-171 22590679-5 2012 However, when dialyzed together with Gst-gp3 or with Gst-gp4, His-gp2b and His-gp4 remain soluble and oligomers are obtained by affinity-chromatography. Histidine 62-65 integrin subunit alpha 2b Homo sapiens 66-70 21895720-7 2012 RESULTS: The ADH1B 47Arg allele was found to be associated with increased risk of UADT cancers, the pooled odds ratios (ORs) being 1.66 (95% CI: 1.54 to 1.79) and 3.47 (95% CI: 2.76 to 4.36) for the His/Arg and Arg/Arg genotypes compared with the His/His genotype, respectively. Histidine 199-202 alcohol dehydrogenase 1B (class I), beta polypeptide Homo sapiens 13-18 21895720-7 2012 RESULTS: The ADH1B 47Arg allele was found to be associated with increased risk of UADT cancers, the pooled odds ratios (ORs) being 1.66 (95% CI: 1.54 to 1.79) and 3.47 (95% CI: 2.76 to 4.36) for the His/Arg and Arg/Arg genotypes compared with the His/His genotype, respectively. Histidine 247-250 alcohol dehydrogenase 1B (class I), beta polypeptide Homo sapiens 13-18 21895720-7 2012 RESULTS: The ADH1B 47Arg allele was found to be associated with increased risk of UADT cancers, the pooled odds ratios (ORs) being 1.66 (95% CI: 1.54 to 1.79) and 3.47 (95% CI: 2.76 to 4.36) for the His/Arg and Arg/Arg genotypes compared with the His/His genotype, respectively. Histidine 247-250 alcohol dehydrogenase 1B (class I), beta polypeptide Homo sapiens 13-18 21890903-2 2012 This unusual G(-1) residue is the major tRNA(His) identity element, and essential for recognition by the cognate histidyl-tRNA synthetase to allow efficient His-tRNA(His) formation. Histidine 45-48 histidyl-tRNA synthetase 1 Homo sapiens 113-137 23028758-1 2012 In humans and mice, the Cys(2)His(2) zinc finger protein PRDM9 binds to a DNA sequence motif enriched in hotspots of recombination, possibly modifying nucleosomes, and recruiting recombination machinery to initiate Double Strand Breaks (DSBs). Histidine 30-33 PR domain containing 9 Mus musculus 57-62 12215545-6 2002 NIF-1 is a 1,342-amino-acid nuclear protein containing a number of conserved domains, including six Cys-2/His-2 zinc fingers, an N-terminal stretch of acidic amino acids, and a C-terminal leucine zipper-like motif. Histidine 106-109 zinc finger protein 335 Homo sapiens 0-5 12237460-7 2002 For ILBP, on the other hand, a more solvent-accessible protein cavity was deduced based on the pH titration behavior of its histidine residues. Histidine 124-133 fatty acid binding protein 6 Homo sapiens 4-8 12224952-8 2002 The most potent compound 1n with the pharmacophore motif "His-DPhe-Arg-Trp" was identified as having an EC(50) value of 165 nM at mMC1R, 7600 nM at mMC3R, 650 nM at mMC4R, and 335 nM at mMC5R. Histidine 58-61 melanocortin 3 receptor Mus musculus 148-153 12082110-2 2002 VN also interacts with two-chain high molecular weight kininogen (HKa), particularly its His-Gly-Lys-rich domain 5, and both HKa and PAI-1 are antiadhesive factors that have been shown to compete for binding to VN. Histidine 89-92 vitronectin Homo sapiens 0-2 12400683-1 2002 The maize response regulator genes ZmRR1 and ZmRR2 respond to cytokinin, and the translated products seem to be involved in nitrogen signal transduction mediated by cytokinin through the His-Asp phosphorelay. Histidine 187-190 cytokinin response regulator 2 Zea mays 45-50 12221648-2 2002 We found that divalent metal Zn2+ can improve the polyfection efficiency, especially with DNA/histidylated polylysine (His-pLK) complexes. Histidine 119-122 polo like kinase 1 Homo sapiens 123-126 12221648-4 2002 Zn2+ is more efficient on DNA/His-pLK complexes: the number of EGFP-positive cells increased from 1% to more than 40%. Histidine 30-33 polo like kinase 1 Homo sapiens 34-37 12221648-8 2002 Flow cytometry and confocal microscopy studies clearly indicate that with His-pLK, the plasmid is better delivered in the cytosol as well as in the cell nucleus in zinc-treated cells. Histidine 74-77 polo like kinase 1 Homo sapiens 78-81 12163583-4 2002 Large-plaque revertants were observed readily following growth of the nsP4 Ser183 mutant at 40 degrees C. Fifteen revertants were characterized, and all had a mutation in the Asn374 codon of nsP1 that changed it to either a His or an Ile codon. Histidine 224-227 SH2 domain containing 3A Homo sapiens 191-195 12198576-3 2002 The recombinant metalloproteinase has an additional sequence of N-terminal 22 amino acids and C-terminal 8 amino acids (housing 6 histidines), both of which derived from the vector. Histidine 130-140 metalloproteinase Escherichia coli 16-33 12149456-3 2002 Here we identify mutations of Tyr-253 in the nucleotide-binding (P) loop of the Abl kinase domain to Phe or His in patients with advanced CML and acquired STI-571 resistance. Histidine 108-111 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 80-83 12138266-6 2002 As a result, addition of protonated histidine at acidic pH(e) to Xenopus oocytes expressing rBAT creates an inward current which is paralleled by cytosolic acidification. Histidine 36-45 bile acid CoA:amino acid N-acyltransferase Rattus norvegicus 92-96 12145341-7 2002 Conversely, the substitution of Y614 of the rFSHR with the cognate hFSHR residue (histidine) fully suppresses the constitutive activity of the rFSHR (D580G) mutant. Histidine 82-91 follicle stimulating hormone receptor Homo sapiens 67-72 12135746-4 2002 Upon binding to this site, which involves a histidine inserted in position 310 (V310H) and the endogenous Cys306 within the same DAT molecule, Zn(2+) potently inhibits [(3)H]dopamine uptake. Histidine 44-53 solute carrier family 6 member 3 Homo sapiens 129-132 12121764-2 2002 KatGs, CCP and APXs contain identical amino acid triads in the heme pocket (distal Arg/Trp/His and proximal His/Trp/Asp), but differ dramatically in their reactivities towards hydrogen peroxide and various one-electron donors. Histidine 91-94 cytochrome-c peroxidase Saccharomyces cerevisiae S288C 7-10 12121764-2 2002 KatGs, CCP and APXs contain identical amino acid triads in the heme pocket (distal Arg/Trp/His and proximal His/Trp/Asp), but differ dramatically in their reactivities towards hydrogen peroxide and various one-electron donors. Histidine 108-111 cytochrome-c peroxidase Saccharomyces cerevisiae S288C 7-10 23028834-4 2012 To gain insight into these interfaces, we used the process of genome-rewiring in yeast by placing an essential metabolic gene HIS3 from the histidine biosynthesis pathway, under the exclusive regulation of different cell-cycle promoters. Histidine 140-149 imidazoleglycerol-phosphate dehydratase HIS3 Saccharomyces cerevisiae S288C 126-130 23028834-5 2012 In a medium lacking histidine and under partial inhibition of the HIS3p, the rewired cells encountered an unforeseen multitasking challenge; the cell-cycle regulatory genes were required to regulate the essential histidine-pathway gene in concert with the other metabolic demands, while simultaneously driving the cell cycle through its proper temporal phases. Histidine 213-222 imidazoleglycerol-phosphate dehydratase HIS3 Saccharomyces cerevisiae S288C 66-71 23028501-6 2012 We show that many translocation-prone pairs of regions genome-wide, including the cancer translocation partners BCR-ABL and MYC-IGH, display elevated Hi-C contact frequencies in normal human cells. Histidine 150-152 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 112-119 21990358-0 2011 Reversible major histocompatibility complex I-peptide multimers containing Ni(2+)-nitrilotriacetic acid peptides and histidine tags improve analysis and sorting of CD8(+) T cells. Histidine 117-126 CD8a molecule Homo sapiens 164-167 12167347-6 2002 In this study, full-length DEN2 NS3 was expressed with an N-terminal histidine tag in Escherichia coli and purified in a soluble form. Histidine 69-78 KRAS proto-oncogene, GTPase Homo sapiens 32-35 12102635-8 2002 However, the cDNA of platelet CKIIalpha has a different amino acid at position 236 (Arg --> His), which is not found in the intronless gene. Histidine 95-98 casein kinase 2 alpha 2 Homo sapiens 30-39 11970955-2 2002 HKa and particularly its His-Gly-Lys-rich domain 5 have been previously reported to exert anti-adhesive properties by binding to the extracellular matrix protein vitronectin (VN). Histidine 25-28 vitronectin Homo sapiens 162-173 11970955-2 2002 HKa and particularly its His-Gly-Lys-rich domain 5 have been previously reported to exert anti-adhesive properties by binding to the extracellular matrix protein vitronectin (VN). Histidine 25-28 vitronectin Homo sapiens 175-177 12056811-1 2002 Histidyl-tRNA synthetase catalyses the covalent ligation of histidine to its cognate tRNA as an early step in protein biosynthesis. Histidine 60-69 histidyl-tRNA synthetase 1 Homo sapiens 0-24 12065604-5 2002 Analysis of the K (i) of recombinant His-tagged rat cystatin E/M toward cathepsins B and H revealed that rat cystatin E/M has an inhibitor profile distinct from that of other members of the cystatin family. Histidine 37-40 cystatin E/M Homo sapiens 52-62 12065604-5 2002 Analysis of the K (i) of recombinant His-tagged rat cystatin E/M toward cathepsins B and H revealed that rat cystatin E/M has an inhibitor profile distinct from that of other members of the cystatin family. Histidine 37-40 cystatin E/M Homo sapiens 109-119 11988102-6 2002 We took advantage of the functionality of the purified material to (i) develop an efficient surface-plasmon resonance assay of the interaction between two calcium channel subunits and (ii) measure, for the first time, the affinity of the recombinant His-beta(4) subunit for the full-length Ca(v)2.1 channel. Histidine 250-253 calcium channel, voltage-dependent, P/Q type, alpha 1A subunit S homeolog Xenopus laevis 290-298 11993992-3 2002 In particular, homologous hydrogen-bonding networks involving a conserved basic residue (His 49 in Pdx, His 56 in Adx, Arg 49 in Tdx) are detailed. Histidine 89-92 ferredoxin 1 Homo sapiens 114-117 11993992-3 2002 In particular, homologous hydrogen-bonding networks involving a conserved basic residue (His 49 in Pdx, His 56 in Adx, Arg 49 in Tdx) are detailed. Histidine 104-107 ferredoxin 1 Homo sapiens 114-117 22131323-3 2011 Divalent cations Zn(2+), Cu(2+) and Ni(2+) inhibit Ca(V)3.2 channels more efficiently than Ca(V)3.1 and Ca(V)3.3 channels via second high-affinity binding site including histidine H191 specific for the Ca(V)3.2 channel. Histidine 170-179 immunoglobulin lambda variable 7-46 Homo sapiens 104-112 21856016-2 2011 Factor H protein is polymorphic at amino acid 402, in which the resulting histidine containing moiety has been established to impart significant risk of AMD. Histidine 74-83 complement factor H Homo sapiens 0-8 21950469-1 2011 We had previously reported that Mitsunobu-based introduction of alkyl substituents onto the imidazole N(pi)-position of a key histidine residue in phosphothreonine-containing peptides can impart high binding affinity against the polo-box domain of polo-like kinase 1. Histidine 126-135 polo like kinase 1 Homo sapiens 248-266 21950761-5 2011 We have developed a new approach to systematically identify the substrates of ubiquitin ligases by identifying proteins that display an enhanced incorporation of His-tagged ubiquitin upon ligase coexpression; using this method, we identified several candidate substrates for BRCA1. Histidine 162-165 BRCA1 DNA repair associated Homo sapiens 275-280 21740978-11 2011 (2) The distance between the SXXK-motif Lys-NZ atom and the Lys/His-nitrogen atom of the (K/H)T(S)G-motif was highly conserved, suggesting importance for PBP function, and a possibly conserved role in the catalytic mechanism of the PBPs. Histidine 64-67 phosphatidylethanolamine binding protein 1 Homo sapiens 154-157 21647637-6 2011 An intron in the 5"-untranslated region and three histidine boxes in the protein, which are characteristic of plant FAD2 genes, have been well-conserved. Histidine 50-59 omega-6 fatty acid desaturase, endoplasmic reticulum Brassica rapa 116-120 21824479-4 2011 We present here the structures of MPPED2 and two mutants, which show that the poor activity of MPPED2 is not only a consequence of the substitution of an active-site histidine residue by glycine but also due to binding of AMP or GMP to the active site. Histidine 166-175 metallophosphoesterase domain containing 2 Homo sapiens 34-40 21824479-4 2011 We present here the structures of MPPED2 and two mutants, which show that the poor activity of MPPED2 is not only a consequence of the substitution of an active-site histidine residue by glycine but also due to binding of AMP or GMP to the active site. Histidine 166-175 metallophosphoesterase domain containing 2 Homo sapiens 95-101 21505784-6 2011 Replacement of residue Gln(992) in the outer pore with the equivalent residue His(995) in the hTRPM2 channel resulted in a mutant mTRPM2 channel with the pH sensitivity and kinetics of inhibition of the wild-type hTRPM2 channel. Histidine 78-81 transient receptor potential cation channel subfamily M member 2 Homo sapiens 94-100 21505784-6 2011 Replacement of residue Gln(992) in the outer pore with the equivalent residue His(995) in the hTRPM2 channel resulted in a mutant mTRPM2 channel with the pH sensitivity and kinetics of inhibition of the wild-type hTRPM2 channel. Histidine 78-81 transient receptor potential cation channel, subfamily M, member 2 Mus musculus 130-136 21505784-6 2011 Replacement of residue Gln(992) in the outer pore with the equivalent residue His(995) in the hTRPM2 channel resulted in a mutant mTRPM2 channel with the pH sensitivity and kinetics of inhibition of the wild-type hTRPM2 channel. Histidine 78-81 transient receptor potential cation channel subfamily M member 2 Homo sapiens 213-219 21505784-9 2011 Taken together, our results suggest a crucial role of residue His(995)/Gln(992) in the outer pore of TRPM2 channels in determining species-dependent effects of extracellular acidic pH. Histidine 62-65 transient receptor potential cation channel subfamily M member 2 Homo sapiens 101-106 21646353-4 2011 We demonstrate that the characteristic His/Met-rich segment Met(672)-Pro(707) (HM-loop) that connects the first two transmembrane segments of ATP7A is important for copper release. Histidine 39-42 ATPase copper transporting alpha Homo sapiens 142-147 21602277-7 2011 Reciprocal mutation of His(995) in the hTRPM2 channel and the equivalent Gln(992) in the mTRPM2 channel completely swapped the kinetics, but no such opposing effects resulted from exchanging another pair of species-specific residues, Arg(961)/Ser(958). Histidine 23-26 transient receptor potential cation channel subfamily M member 2 Homo sapiens 39-45 21602277-7 2011 Reciprocal mutation of His(995) in the hTRPM2 channel and the equivalent Gln(992) in the mTRPM2 channel completely swapped the kinetics, but no such opposing effects resulted from exchanging another pair of species-specific residues, Arg(961)/Ser(958). Histidine 23-26 transient receptor potential cation channel, subfamily M, member 2 Mus musculus 89-95 21666675-2 2011 Most missense mutations in the OCRL ASH-RhoGAP domain that are found in affected individuals abolish interactions with the endocytic adaptors APPL1 and Ses (both Ses1 and Ses2), which bind OCRL through a short phenylalanine and histidine (F&H) motif. Histidine 228-237 Rho GTPase activating protein 1 Homo sapiens 40-46 21666675-2 2011 Most missense mutations in the OCRL ASH-RhoGAP domain that are found in affected individuals abolish interactions with the endocytic adaptors APPL1 and Ses (both Ses1 and Ses2), which bind OCRL through a short phenylalanine and histidine (F&H) motif. Histidine 228-237 secernin 2 Homo sapiens 171-175 21390047-6 2011 Importantly, adjusted Cox regression analysis not only confirmed ERCC5 1104 His/His as an independent prognostic factor (multivariate HR=4.5; P<0.001), but also revealed the significant impact of ERCC2 (XPD) 751 Gln/Gln on prognosis, with a 2.2-fold increased HR compared with ERCC2 751 Lys/Lys (P=0.009). Histidine 76-79 ERCC excision repair 5, endonuclease Homo sapiens 65-70 21390047-6 2011 Importantly, adjusted Cox regression analysis not only confirmed ERCC5 1104 His/His as an independent prognostic factor (multivariate HR=4.5; P<0.001), but also revealed the significant impact of ERCC2 (XPD) 751 Gln/Gln on prognosis, with a 2.2-fold increased HR compared with ERCC2 751 Lys/Lys (P=0.009). Histidine 80-83 ERCC excision repair 5, endonuclease Homo sapiens 65-70 21143365-9 2011 Proinsulin from tobacco leaves was purified up to 98% using metal affinity chromatography without any His-tag. Histidine 102-105 insulin II Mus musculus 0-10 11978727-3 2002 Based on sequence analysis, Png1p was classified as a member of the "transglutaminase-like superfamily" that contains a putative catalytic triad of amino acids (cysteine, histidine, and aspartic acid). Histidine 171-180 peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase Saccharomyces cerevisiae S288C 28-33 11966977-6 2002 For these peptides, the affinity and activity at all three human receptors (MC3R, MC4R and MC5R) decreased significantly, demonstrating that the His-Phe-Arg-Trp sequence in gamma-MSH is important for activity at these three melanocortin receptors. Histidine 145-148 melanocortin 5 receptor Homo sapiens 91-95 11812789-4 2002 Cys-191, His-218, and Asp-235 of Png1p are conserved in the sequence of factor XIIIa, where these amino acids constitute a catalytic triad. Histidine 9-12 peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase Saccharomyces cerevisiae S288C 33-38 11913972-0 2002 Heterologous expression of an endogenous rat cytochrome b(5)/cytochrome b(5) reductase fusion protein: identification of histidines 62 and 85 as the heme axial ligands. Histidine 121-131 cytochrome b5 type A Rattus norvegicus 45-60 11913972-0 2002 Heterologous expression of an endogenous rat cytochrome b(5)/cytochrome b(5) reductase fusion protein: identification of histidines 62 and 85 as the heme axial ligands. Histidine 121-131 cytochrome b5 type A Rattus norvegicus 61-76 11884629-0 2002 Involvement of conserved histidine, lysine and tyrosine residues in the mechanism of DNA cleavage by the caspase-3 activated DNase CAD. Histidine 25-34 caspase 3 Mus musculus 105-114 11876652-0 2002 Alcaligenes xylosoxidans dissimilatory nitrite reductase: alanine substitution of the surface-exposed histidine 139l ligand of the type 1 copper center prevents electron transfer to the catalytic center. Histidine 102-111 nitrite reductase large subunit Achromobacter xylosoxidans 39-56 11904683-3 2002 The deduced amino acid sequences of both Ciona C3-like proteins exhibit a canonical processing site for alpha and beta chains, a thioester site with an associated catalytic histidine and a convertase cleavage site, thus showing an overall similarity to the other C3 molecules already characterized. Histidine 173-182 complement component C3 Ciona intestinalis 47-49 11741896-6 2002 In GIRK4/GIRK1 heteromers the GIRK4 His-64 and Leu-268 residues showed greater contributions to G beta zeta sensitivity than did the corresponding GIRK1 His-57 and Leu-262 residues. Histidine 36-39 potassium inwardly rectifying channel subfamily J member 5 Homo sapiens 3-8 11741896-6 2002 In GIRK4/GIRK1 heteromers the GIRK4 His-64 and Leu-268 residues showed greater contributions to G beta zeta sensitivity than did the corresponding GIRK1 His-57 and Leu-262 residues. Histidine 36-39 potassium inwardly rectifying channel subfamily J member 5 Homo sapiens 30-35 11802791-1 2002 The ability of the lysosomal cysteine protease cathepsin B to function as a peptidyldipeptidase (removing C-terminal dipeptides) has been attributed to the presence of two histidine residues (His(110) and His(111)) present in the occluding loop, an extra peptide segment located in the primed side of the active-site cleft. Histidine 172-181 cathepsin B Homo sapiens 47-58 11802791-1 2002 The ability of the lysosomal cysteine protease cathepsin B to function as a peptidyldipeptidase (removing C-terminal dipeptides) has been attributed to the presence of two histidine residues (His(110) and His(111)) present in the occluding loop, an extra peptide segment located in the primed side of the active-site cleft. Histidine 192-195 cathepsin B Homo sapiens 47-58 11802791-1 2002 The ability of the lysosomal cysteine protease cathepsin B to function as a peptidyldipeptidase (removing C-terminal dipeptides) has been attributed to the presence of two histidine residues (His(110) and His(111)) present in the occluding loop, an extra peptide segment located in the primed side of the active-site cleft. Histidine 205-208 cathepsin B Homo sapiens 47-58 11895452-7 2002 Histidine at position 30 of the HLA-DQB1 gene was found in 22% of Group II but in none of Group I patients. Histidine 0-9 major histocompatibility complex, class II, DQ beta 1 Homo sapiens 32-40 11815678-6 2002 It is speculated that the site-specific inactivation of TPO might have occurred at the heme-linked histidine residue of the TPO molecule, a critical amino acid for enzyme activity because OH* (vicious free radicals) can be formed at the iron-linked amino acid. Histidine 99-108 thyroid peroxidase Homo sapiens 56-59 11815678-6 2002 It is speculated that the site-specific inactivation of TPO might have occurred at the heme-linked histidine residue of the TPO molecule, a critical amino acid for enzyme activity because OH* (vicious free radicals) can be formed at the iron-linked amino acid. Histidine 99-108 thyroid peroxidase Homo sapiens 124-127 11820929-4 2002 Among the six totally-conserved His residues of cytochrome b(561) in higher vertebrates, one is substituted with an Asn residue, indicating that His88 and His161 of bovine cytochrome b(561) play roles as heme b ligands at the extravesicular side. Histidine 32-35 cytochrome b Bos taurus 48-60 11820929-4 2002 Among the six totally-conserved His residues of cytochrome b(561) in higher vertebrates, one is substituted with an Asn residue, indicating that His88 and His161 of bovine cytochrome b(561) play roles as heme b ligands at the extravesicular side. Histidine 32-35 cytochrome b Bos taurus 172-184 11739191-2 2001 A 68.5-kd chimeric protein (His-M195FANCF) was expressed, consisting of a His tag, a single-chain antibody to the myeloid antigen CD33, and the FANCF protein, as well as a 43-kd His-FANCF fusion protein lacking the antibody motif, in Escherichia coli. Histidine 28-31 FA complementation group F Homo sapiens 36-41 11739191-2 2001 A 68.5-kd chimeric protein (His-M195FANCF) was expressed, consisting of a His tag, a single-chain antibody to the myeloid antigen CD33, and the FANCF protein, as well as a 43-kd His-FANCF fusion protein lacking the antibody motif, in Escherichia coli. Histidine 28-31 FA complementation group F Homo sapiens 144-149 11739191-3 2001 The nickel-agarose-purified His-M195FANCF protein bound specifically to the surface of HeLa cells transfected with CD33 and internalized through vesicular structures. Histidine 28-31 FA complementation group F Homo sapiens 36-41 11739191-7 2001 The intracellular half-life of His-M195FANCF was approximately 160 minutes. Histidine 31-34 FA complementation group F Homo sapiens 39-44 11739191-8 2001 Treatment of CD33-transfected FA group F lymphoblastoid cells with 0.1 mg/mL His-M195FANCF conferred resistance to mitomycin C. Histidine 77-80 FA complementation group F Homo sapiens 85-90 11731079-4 2001 The predicted protein sequence displayed extensive similarity to that of known MMP-9s and contained a putative signal sequence, a propeptide, an active site with three zinc-binding histidine residues, a calcium-binding domain, a hemopexin region, and three key cysteine residues. Histidine 181-190 matrix metallopeptidase 9 Canis lupus familiaris 79-84 11673563-9 2001 Furthermore, a point-mutated Dsg3 molecule containing Dsg1-specific amino acid substitutions (His(25), Cys(28), Ala(29)) reacted with anti-Dsg1 IgG, thus defining one of the epitopes of Dsg1. Histidine 94-97 desmoglein 3 Mus musculus 29-33 11673563-9 2001 Furthermore, a point-mutated Dsg3 molecule containing Dsg1-specific amino acid substitutions (His(25), Cys(28), Ala(29)) reacted with anti-Dsg1 IgG, thus defining one of the epitopes of Dsg1. Histidine 94-97 desmoglein 1 alpha Mus musculus 54-58 11673563-9 2001 Furthermore, a point-mutated Dsg3 molecule containing Dsg1-specific amino acid substitutions (His(25), Cys(28), Ala(29)) reacted with anti-Dsg1 IgG, thus defining one of the epitopes of Dsg1. Histidine 94-97 desmoglein 1 alpha Mus musculus 139-143 11673563-9 2001 Furthermore, a point-mutated Dsg3 molecule containing Dsg1-specific amino acid substitutions (His(25), Cys(28), Ala(29)) reacted with anti-Dsg1 IgG, thus defining one of the epitopes of Dsg1. Histidine 94-97 desmoglein 1 alpha Mus musculus 139-143 21296058-9 2011 Molecular modeling of BADH revealed that the oxidized methionine and histidine residues are near the NAD(+) binding site. Histidine 69-78 aldehyde dehydrogenase 7 family member A1 Homo sapiens 22-26 21563332-0 2004 (111)In-DOTA-4-amino-1-carboxymethyl-piperidine-D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2 The amphibian bombesin (BBN or BN, a peptide of 14 amino acids) is an analog of human gastrin-releasing peptide (GRP, a peptide of 27 amino acids) that binds to GRP receptor (GRPR) with high affinity and specificity (1). Histidine 74-77 gastrin releasing peptide Homo sapiens 104-112 21563332-0 2004 (111)In-DOTA-4-amino-1-carboxymethyl-piperidine-D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2 The amphibian bombesin (BBN or BN, a peptide of 14 amino acids) is an analog of human gastrin-releasing peptide (GRP, a peptide of 27 amino acids) that binds to GRP receptor (GRPR) with high affinity and specificity (1). Histidine 74-77 gastrin releasing peptide Homo sapiens 176-201 21563332-0 2004 (111)In-DOTA-4-amino-1-carboxymethyl-piperidine-D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2 The amphibian bombesin (BBN or BN, a peptide of 14 amino acids) is an analog of human gastrin-releasing peptide (GRP, a peptide of 27 amino acids) that binds to GRP receptor (GRPR) with high affinity and specificity (1). Histidine 74-77 gastrin releasing peptide Homo sapiens 203-206 21505254-3 2011 In this study, the N-terminal domain of human RPL7a was overexpressed in Escherichia coli using an engineered C-terminal His tag. Histidine 121-124 ribosomal protein L7a Homo sapiens 46-51 11669611-5 2001 (i) Mature PsaD of spinach and PsaD of the prokaryotic caynobacterium Mastigocladus laminosus, both bearing a six-histidine tag at their C-termini, were overexpressed in Escherichia coli and purified to homogeneity. Histidine 114-123 uncharacterized protein Chlamydomonas reinhardtii 11-15 11669611-5 2001 (i) Mature PsaD of spinach and PsaD of the prokaryotic caynobacterium Mastigocladus laminosus, both bearing a six-histidine tag at their C-termini, were overexpressed in Escherichia coli and purified to homogeneity. Histidine 114-123 uncharacterized protein Chlamydomonas reinhardtii 31-35 11514573-7 2001 Thus, proton has both stimulatory and inhibitory effects on the Kir6.2 channels, which attribute to two sets of histidine residues in the C terminus. Histidine 112-121 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 64-70 11600717-6 2001 A c-Fos/c-Jun complex was generated by co-renaturation and purified via a His-tag on the full-length human c-Fos. Histidine 74-77 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 2-7 11600717-6 2001 A c-Fos/c-Jun complex was generated by co-renaturation and purified via a His-tag on the full-length human c-Fos. Histidine 74-77 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 8-13 11600717-6 2001 A c-Fos/c-Jun complex was generated by co-renaturation and purified via a His-tag on the full-length human c-Fos. Histidine 74-77 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 107-112 11481322-4 2001 Direct physical interactions between the N- and C-zinc finger domains of GATA-4 and the cysteine/histidine-rich region 3 (C/H3) of p300 were identified in immunoprecipitation and glutathione S-transferase pull-down experiments. Histidine 97-106 E1A binding protein p300 Mus musculus 131-135 20888915-1 2011 When the 34 kDa kinase domain of human spleen tyrosine kinase (Syk-KD) was expressed as a C-terminally His-tagged protein in baculovirus-infected Sf-21 insect cells, the purified protein included two forms that migrated slightly differently in SDS-polyacrylamide gel electrophoresis. Histidine 103-106 spleen associated tyrosine kinase Homo sapiens 63-66 11564711-3 2001 To protect from DPP IV, we have studied the biological activity of a GLP-1 analog in which 6-aminohexanoic acid (Aha) is inserted between histidine and alanine at positions 7 and 8. Histidine 138-147 glucagon Rattus norvegicus 69-74 11562206-0 2001 A distal histidine mutant (H52Q) of yeast cytochrome c peroxidase catalyzes the oxidation of H(2)O(2) instead of its reduction. Histidine 9-18 cytochrome-c peroxidase Saccharomyces cerevisiae S288C 42-65 11562206-1 2001 A H52Q variant of yeast cytochrome c peroxidase (CcP), in which the distal histidine is replaced by glutamine, catalyzes oxidation of H(2)O(2) instead of reduction. Histidine 75-84 cytochrome-c peroxidase Saccharomyces cerevisiae S288C 24-47 11562206-1 2001 A H52Q variant of yeast cytochrome c peroxidase (CcP), in which the distal histidine is replaced by glutamine, catalyzes oxidation of H(2)O(2) instead of reduction. Histidine 75-84 cytochrome-c peroxidase Saccharomyces cerevisiae S288C 49-52 11551224-0 2001 Evidence for essential histidines in human pituitary glutaminyl cyclase. Histidine 23-33 glutaminyl-peptide cyclotransferase Homo sapiens 53-71 11527429-6 2001 S100A4 had a greater affinity for wild-type or mutant arg-175-his p53 than for non-muscle myosin. Histidine 62-65 S100 calcium binding protein A4 Homo sapiens 0-6 21604555-7 2011 RESULTS: Soluble expression of orf20 gene in E. coli was achieved, and the recombinant ORF20 protein was tagged by seven histidines at the carboxylic end. Histidine 121-131 hypothetical protein Escherichia coli 87-92 21167151-5 2011 The intake of histidine or carnosine significantly diminished the activity and mRNA expression of malic enzyme, FAS, HMG-CoA reductase, SREBP-1c and SREBP-2, which led to lower body weight, epididymal fat, and hepatic triglyceride and cholesterol levels (P<0.05). Histidine 14-23 sterol regulatory element binding factor 2 Mus musculus 149-156 21687413-6 2011 We confirmed the binding domains using a pull-down assay and showed that GST-CdsN(221-270), which encompasses these peptides, co-purified with His-CdsL. Histidine 143-146 corneodesmosin Homo sapiens 77-81 20978135-0 2011 Histidine 103 in Fra2 is an iron-sulfur cluster ligand in the [2Fe-2S] Fra2-Grx3 complex and is required for in vivo iron signaling in yeast. Histidine 0-9 Bol2p Saccharomyces cerevisiae S288C 17-21 20978135-0 2011 Histidine 103 in Fra2 is an iron-sulfur cluster ligand in the [2Fe-2S] Fra2-Grx3 complex and is required for in vivo iron signaling in yeast. Histidine 0-9 Bol2p Saccharomyces cerevisiae S288C 71-75 20978135-0 2011 Histidine 103 in Fra2 is an iron-sulfur cluster ligand in the [2Fe-2S] Fra2-Grx3 complex and is required for in vivo iron signaling in yeast. Histidine 0-9 monothiol glutaredoxin GRX3 Saccharomyces cerevisiae S288C 76-80 20980517-3 2011 We identified here three residues in the shared domain of the P and V proteins-tyrosine 110, valine 112, and histidine 115-that function to retain STAT1 in the cytoplasm and inhibit interferon transcription. Histidine 109-118 signal transducer and activator of transcription 1 Homo sapiens 147-152 11513747-0 2001 Regulation of SulA cleavage by Lon protease by the C-terminal amino acid of SulA, histidine. Histidine 82-91 putative ATP-dependent Lon protease Escherichia coli 31-34 11513747-4 2001 Substitution of the extreme C-terminal histidine residue with another amino acid led to marked accumulation and high stability of SulA in lon(+) cells. Histidine 39-48 putative ATP-dependent Lon protease Escherichia coli 138-141 11513747-7 2001 Histidine competitively inhibited the degradation of MBP-SulA by Lon, while other amino acids did not. Histidine 0-9 putative ATP-dependent Lon protease Escherichia coli 65-68 11513747-8 2001 These results suggest that the histidine residue at the extreme C-terminus of SulA is recognized specifically by Lon, leading to a high-affinity interaction between SulA and Lon. Histidine 31-40 putative ATP-dependent Lon protease Escherichia coli 113-116 11513747-8 2001 These results suggest that the histidine residue at the extreme C-terminus of SulA is recognized specifically by Lon, leading to a high-affinity interaction between SulA and Lon. Histidine 31-40 putative ATP-dependent Lon protease Escherichia coli 174-177 11683252-9 2001 This assay showed that histidine was pegylated preferentially at low pH levels with another protein, rh-Interleukin-10. Histidine 23-32 interleukin 10 Homo sapiens 104-118 11561725-4 2001 The sequences around the proposed active site Asp, His, and Ser residues of KpcA are similar to those of other Kex2p family members. Histidine 51-54 kexin KEX2 Saccharomyces cerevisiae S288C 111-116 11528481-5 2001 Here we report, using a histidine scan of the initial C-linker of the CNG1 channel, stripes of sites producing Ni2+ potentiation or Ni2+ inhibition, separated by 50 degrees on an alpha-helix. Histidine 24-33 cyclic nucleotide gated channel subunit alpha 1 Homo sapiens 70-74 11502179-1 2001 The amino-terminal ectodomain of the human TSH receptor has been expressed at the surface of CHO cells as a glycosylphosphatidylinositol-anchored molecule containing a 10-residue histidine tag close to its C terminus. Histidine 179-188 thyroid stimulating hormone receptor Homo sapiens 43-55 21157980-5 2010 RESULTS: Individuals with ADH1B arginine (Arg)/Arg genotype showed 3.95-fold increased ESCC risk in the recessive genetic model [Arg/Arg vs Arg/histidine (His) + His/His: odds ratio (OR) = 3.95, 95% confidence interval (CI): 2.76-5.67]. Histidine 144-153 alcohol dehydrogenase 1B (class I), beta polypeptide Homo sapiens 26-31 21157980-5 2010 RESULTS: Individuals with ADH1B arginine (Arg)/Arg genotype showed 3.95-fold increased ESCC risk in the recessive genetic model [Arg/Arg vs Arg/histidine (His) + His/His: odds ratio (OR) = 3.95, 95% confidence interval (CI): 2.76-5.67]. Histidine 155-158 alcohol dehydrogenase 1B (class I), beta polypeptide Homo sapiens 26-31 21157980-5 2010 RESULTS: Individuals with ADH1B arginine (Arg)/Arg genotype showed 3.95-fold increased ESCC risk in the recessive genetic model [Arg/Arg vs Arg/histidine (His) + His/His: odds ratio (OR) = 3.95, 95% confidence interval (CI): 2.76-5.67]. Histidine 162-165 alcohol dehydrogenase 1B (class I), beta polypeptide Homo sapiens 26-31 21157980-5 2010 RESULTS: Individuals with ADH1B arginine (Arg)/Arg genotype showed 3.95-fold increased ESCC risk in the recessive genetic model [Arg/Arg vs Arg/histidine (His) + His/His: odds ratio (OR) = 3.95, 95% confidence interval (CI): 2.76-5.67]. Histidine 162-165 alcohol dehydrogenase 1B (class I), beta polypeptide Homo sapiens 26-31 20934430-0 2010 Alternative oligomeric states of the yeast Rvb1/Rvb2 complex induced by histidine tags. Histidine 72-81 RuvB family ATP-dependent DNA helicase reptin Saccharomyces cerevisiae S288C 48-52 20934430-4 2010 We found that histidine-tagged constructs of yeast Rvb proteins employed in some of these studies induced the assembly of double hexameric ring Rvb1/Rvb2 complexes. Histidine 14-23 RuvB family ATP-dependent DNA helicase reptin Saccharomyces cerevisiae S288C 149-153 20801892-4 2010 TRV120027 (Sar-Arg-Val-Tyr-Ile-His-Pro-D-Ala-OH) competitively antagonizes angiotensin II-stimulated G protein signaling, but stimulates beta-arrestin recruitment and activates several kinase pathways, including p42/44 mitogen-activated protein kinase, Src, and endothelial nitric-oxide synthase phosphorylation via beta-arrestin coupling. Histidine 31-34 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 253-256 21028829-2 2010 The shortest PTH analogue displaying nanomolar potency is the undecapeptide H-Aib-Val-Aib-Glu-Ile-Gln-Leu-Nle-His-Gln-Har-NH(2) that contains two helix-stabilizing residues (Aib(1,3)). Histidine 110-113 ANIB1 Homo sapiens 78-81 21028829-2 2010 The shortest PTH analogue displaying nanomolar potency is the undecapeptide H-Aib-Val-Aib-Glu-Ile-Gln-Leu-Nle-His-Gln-Har-NH(2) that contains two helix-stabilizing residues (Aib(1,3)). Histidine 110-113 ANIB1 Homo sapiens 86-89 21028829-2 2010 The shortest PTH analogue displaying nanomolar potency is the undecapeptide H-Aib-Val-Aib-Glu-Ile-Gln-Leu-Nle-His-Gln-Har-NH(2) that contains two helix-stabilizing residues (Aib(1,3)). Histidine 110-113 ANIB1 Homo sapiens 86-89 20939030-0 2010 Detection and identification of protein-phosphorylation sites in histidines through HNP correlation patterns. Histidine 65-75 kallikrein related peptidase 8 Homo sapiens 84-87 11463578-13 2001 Determining the tertiary structure of 3beta-HSD/isomerase will clarify the mechanistic roles of potentially critical amino acids (His(261), Tyr(253)) that have been identified in the primary structure. Histidine 130-133 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 38-47 11278438-1 2001 We report a novel phospholipase A(2) (PLA(2)), group XII (GXII) PLA(2), distinct from other cysteine-rich groups with a catalytic histidine motif, by its 20-kDa size and distribution of the 14 cysteine residues within the protein. Histidine 130-139 phospholipase A2, group IB, pancreas Mus musculus 18-36 11278438-1 2001 We report a novel phospholipase A(2) (PLA(2)), group XII (GXII) PLA(2), distinct from other cysteine-rich groups with a catalytic histidine motif, by its 20-kDa size and distribution of the 14 cysteine residues within the protein. Histidine 130-139 phospholipase A2, group IB, pancreas Mus musculus 38-44 11278438-1 2001 We report a novel phospholipase A(2) (PLA(2)), group XII (GXII) PLA(2), distinct from other cysteine-rich groups with a catalytic histidine motif, by its 20-kDa size and distribution of the 14 cysteine residues within the protein. Histidine 130-139 phospholipase A2, group IB, pancreas Mus musculus 64-70 11278563-3 2001 Tankyrase 2 is a 130-kDa protein, which lacks the N-terminal histidine/proline/serine-rich region of tankyrase, but contains a corresponding ankyrin repeat region, sterile alpha motif module, and poly(ADP-ribose) polymerase homology domain. Histidine 61-70 tankyrase 2 Homo sapiens 0-11 11302935-17 2001 The reported tyrosine to histidine polymorphism in UGT2B7 does not alter the formation rate of epirubicin glucuronide, and undiscovered genetic polymorphisms in UGT2B7 might change the metabolic fate of this important anticancer agent. Histidine 25-34 UDP glucuronosyltransferase family 2 member B7 Homo sapiens 51-57 11300772-4 2001 Moreover, DEPC inactivates cytochrome b(561) more rapidly at alkaline pH, consistent with modification of a histidine residue. Histidine 108-117 mitochondrially encoded cytochrome b Homo sapiens 27-39 11274462-2 2001 In this paper we show that amino acid substitutions at the fully exposed Lys15 in bovine pancreatic trypsin inhibitor (BPTI) influenced the CD- and DSC-monitored stability: The T(den) difference between the least (P1 Trp) and the most stable (P1 His) mutant is 11.2 degrees C at pH 2.0. Histidine 246-249 spleen trypsin inhibitor I Bos taurus 119-123 11264014-4 2001 Heme dissociated from the reduced cyt b(5) protein at pH approximately 3.5, whereas its rate decreased under CO atmosphere compared with N(2) atmosphere, due to formation of a heme&bond;CO adduct with a histidine as an axial ligand. Histidine 207-216 mitochondrially encoded cytochrome b Homo sapiens 34-41 11038361-2 2001 The active site residue His(10), central in the catalytic mechanism of dPGM, is present as a phosphohistidine with occupancy of 0.28. Histidine 24-27 Phosphoglucose mutase 1 Drosophila melanogaster 71-75 11038361-4 2001 The C-terminal 10-residue tail, which is not observed in previous dPGM structures, is well ordered and interacts with residues implicated in substrate binding; the displacement of a loop adjacent to the active histidine brings previously overlooked residues into positions where they may directly influence catalysis. Histidine 210-219 Phosphoglucose mutase 1 Drosophila melanogaster 66-70 20428263-2 2001 Genetic analysis of the proband found evidence for two distinct mutations of the MYH7 gene (the gene coding for the beta-myosin heavy chain): 403Arg--> Trp in exon 13 and a novel mutation, 453Arg--> His, in exon 14. Histidine 205-208 myosin heavy chain 7 Homo sapiens 81-85 11123909-1 2000 Previously, we have identified three Zn(2+) binding residues in an endogenous Zn(2+) binding site in the human dopamine transporter (hDAT): (193)His in extracellular loop 2 (ECL 2), (375)His at the external end of transmembrane segment (TM) 7, and (396)Glu at the external end of TM 8. Histidine 145-148 solute carrier family 6 member 3 Homo sapiens 111-131 11123909-1 2000 Previously, we have identified three Zn(2+) binding residues in an endogenous Zn(2+) binding site in the human dopamine transporter (hDAT): (193)His in extracellular loop 2 (ECL 2), (375)His at the external end of transmembrane segment (TM) 7, and (396)Glu at the external end of TM 8. Histidine 145-148 tetraspanin 16 Homo sapiens 280-284 11123909-1 2000 Previously, we have identified three Zn(2+) binding residues in an endogenous Zn(2+) binding site in the human dopamine transporter (hDAT): (193)His in extracellular loop 2 (ECL 2), (375)His at the external end of transmembrane segment (TM) 7, and (396)Glu at the external end of TM 8. Histidine 187-190 solute carrier family 6 member 3 Homo sapiens 111-131 11137123-2 2000 The cDNA of equine IL2 or IL4 was cloned in a mammalian expression vector, containing c-terminal myc- and six histidines His(6)-epitopes for recognition and purification of equine cytokines. Histidine 110-120 interleukin 2 Equus caballus 19-22 11152303-0 2000 An internal histidine residue from the bacterial surface protein, PAM, mediates its binding to the kringle-2 domain of human plasminogen. Histidine 12-21 peptidylglycine alpha-amidating monooxygenase Homo sapiens 66-69 11152303-2 2000 Significant kringle-induced chemical shifts in a His side-chain of a1-PAM were revealed by two-dimensional NMR. Histidine 49-52 peptidylglycine alpha-amidating monooxygenase Homo sapiens 70-73 11082534-4 2000 In the present paper, the murine ADRP has been expressed as a recombinant histidine-tagged protein in Escherichia coli, and purified from expressing cultures in order to examine its biochemical properties. Histidine 74-83 perilipin 2 Mus musculus 33-37 11063570-6 2000 One major difference between the two CA isoforms, within the amino-terminal region, is a high content of histidine residues in CAII (His3, -4, -10, -15, -17) not found in CAI. Histidine 105-114 carbonic anhydrase 2 Homo sapiens 127-131 11063570-7 2000 Mutation of pairs of these histidines (and one lysine) in CAII to the analogous residues in CAI (H3P/H4D or K9D/H10K or H15Q/H17S), or combinations of these various double mutants, did not greatly affect binding between GST-Ct and the mutant CAII. Histidine 27-37 carbonic anhydrase 2 Homo sapiens 58-62 11063596-1 2000 The alkaline conformational transition of a lysine 73 --> histidine variant of iso-1-cytochrome c has been studied. Histidine 61-70 eukaryotic translation initiation factor 1 Homo sapiens 82-87 10934209-4 2000 The three-dimensional structure of the Bir3 domain of XIAP, determined by NMR spectroscopy, resembles a classical zinc finger and consists of five alpha-helices, a three-stranded beta-sheet, and a zinc atom chelated to three cysteines and one histidine. Histidine 243-252 X-linked inhibitor of apoptosis Homo sapiens 54-58 11005799-6 2000 The first three-dimensional structure of a member of the NAT family identifies a catalytic triad consisting of aspartate, histidine and cysteine proposed to form the activation mechanism. Histidine 122-131 bromodomain containing 2 Homo sapiens 57-60 10985787-2 2000 The binding of E12 was localized to the N-terminal, regulatory domain of VanR which contains Asp-55, the residue which accepts the phosphoryl group from His-164 in the activated VanS sensor kinase. Histidine 153-156 VanR Enterococcus faecium 73-77 10898935-5 2000 AtUBP5 was active without 311 amino acids N-terminal to the active site cysteine, or without 233 nonconserved amino acids between the Cys and His boxes, or without both, indicating the core region was sufficient. Histidine 142-145 ubiquitin-specific protease 5 Arabidopsis thaliana 0-6 20977193-3 2010 The active site of this superfamily of enzymes includes a Ser1/Ser2(Tyr)/Lys1(His)/Lys2 tetrad in which Ser1 is a nucleophilic catalyst that becomes acylated in the formation of an acyl-enzyme intermediate. Histidine 78-81 aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Homo sapiens 83-87 20084469-5 2010 DT-SCF gene coding for 1-387 amino acids of diphtheria toxin, His-Ala linker, 2-141 amino acids of SCF was cloned into expression vector with C terminal His tag. Histidine 62-65 KIT ligand Homo sapiens 3-6 20084469-5 2010 DT-SCF gene coding for 1-387 amino acids of diphtheria toxin, His-Ala linker, 2-141 amino acids of SCF was cloned into expression vector with C terminal His tag. Histidine 153-156 KIT ligand Homo sapiens 3-6 20880231-1 2010 The effect of 8-methoxypsoralen-UVA therapy on the catalysis of histidine to trans-urocanic acid by histidine ammonia lyase (HAL, EC 4.3.1.3) was examined using an enzymatic assay from Sigma-Aldrich where the growth of the trans-urocanic acid peak at 277 nm was monitored. Histidine 64-73 histidine ammonia-lyase Homo sapiens 100-123 20880231-1 2010 The effect of 8-methoxypsoralen-UVA therapy on the catalysis of histidine to trans-urocanic acid by histidine ammonia lyase (HAL, EC 4.3.1.3) was examined using an enzymatic assay from Sigma-Aldrich where the growth of the trans-urocanic acid peak at 277 nm was monitored. Histidine 64-73 histidine ammonia-lyase Homo sapiens 125-128 20660104-4 2010 We found the permeability of GlySar to be saturable (K(m) = 5.7 mM), pH-dependent (maximal value at pH 5.5), and specific for PEPT1; other peptide transporters, such as PHT1 and PHT2, were not involved, as judged by the lack of GlySar inhibition by excess concentrations of histidine. Histidine 274-283 solute carrier family 15 (oligopeptide transporter), member 1 Mus musculus 126-131 20629116-1 2010 A series of peptide-peptoid hybrids, containing N-substituted glycines, were synthesized based on the H-Aib-Val-Aib-Glu-Ile-Gln-Leu-Nle-His-Gln-Har-NH(2) (Har = Homoarginine) as the parent parathyroid hormone (1-11) analog. Histidine 136-139 ANIB1 Homo sapiens 104-107 10972423-4 2000 A mutation in her DHAPAT complementary DNA resulted in the substitution of an arginine residue in the protein at position 211 by a histidine (R211H). Histidine 131-140 glyceronephosphate O-acyltransferase Homo sapiens 18-24 20629116-1 2010 A series of peptide-peptoid hybrids, containing N-substituted glycines, were synthesized based on the H-Aib-Val-Aib-Glu-Ile-Gln-Leu-Nle-His-Gln-Har-NH(2) (Har = Homoarginine) as the parent parathyroid hormone (1-11) analog. Histidine 136-139 ANIB1 Homo sapiens 112-115 20600126-2 2010 Peptide agonists of the MC4R are characterized by the conserved sequence His(6)-Phe(7)-Arg(8)-Trp(9), which is crucial for their interaction with the receptor. Histidine 73-76 melanocortin 4 receptor Homo sapiens 24-28 20402667-2 2010 Here, we have characterized a novel USP44 (ubiquitin-specific protease 44), which has a ZnF-UBP (zinc-finger ubiquitin-specific protease) domain and conserved cysteine, histidine and asparagine/aspartic acid residues characteristic of deubiquitinating enzymes. Histidine 169-178 ubiquitin specific peptidase 44 Mus musculus 36-41 10727410-10 2000 The modifications at His(111) (H111A) and His(110) (H110A) of cathepsin B led to an increase in k(cat) values of one or two orders of magnitude. Histidine 21-24 cathepsin B Homo sapiens 62-73 10686340-4 2000 As a first step, the conserved cysteine (C) and histidine (H) residues were targeted for site-directed mutagenesis as potential amino acid residues involved in the N-acetylation reaction of AA-NAT. Histidine 48-57 aralkylamine N-acetyltransferase Homo sapiens 190-196 10686340-5 2000 Our studies concluded that among 6 histidine (H) to alanine (A) mutations, three residues (H110A, H118A, H120A) within the AA-NAT protein showed little or no enzymatic activity, whereas the others (H28A, H70A, H125A) retained enzymatic activity, compared to the unaltered AA-NAT protein. Histidine 35-44 aralkylamine N-acetyltransferase Homo sapiens 123-129 10686340-5 2000 Our studies concluded that among 6 histidine (H) to alanine (A) mutations, three residues (H110A, H118A, H120A) within the AA-NAT protein showed little or no enzymatic activity, whereas the others (H28A, H70A, H125A) retained enzymatic activity, compared to the unaltered AA-NAT protein. Histidine 35-44 aralkylamine N-acetyltransferase Homo sapiens 272-278 10617633-7 2000 Point mutations of conserved cysteine residues or a histidine in the RING finger domain, which are required for zinc binding, abrogated the ability of Cbl to negatively regulate Syk in COS-7 cells and Ramos B lymphocytic cells. Histidine 52-61 spleen associated tyrosine kinase Homo sapiens 178-181 11030070-6 2000 A novel point mutation located in codon 126 of the connexin32 gene, substituting a histidine for a tyrosine, was found in the index patient, in the mother, in two sisters and in a brother. Histidine 83-92 gap junction protein beta 1 Homo sapiens 51-61 10668803-1 2000 Rpb5-H147R is an AT-GC transition replacing CAC(His) by CGC(Arg) at a conserved and critical position of ABC27 (Rpb5p), one of the five common and essential subunits shared by all three eukaryotic RNA polymerases. Histidine 48-51 ATP binding cassette subfamily F member 1 Homo sapiens 105-110 10601246-2 1999 Recently, we have described a distance constraint in the unknown tertiary structure of the human dopamine transporter (hDAT) by identification of two histidines, His(193) in the second extracellular loop and His(375) at the top of transmembrane (TM) 7, that form two coordinates in an endogenous, high affinity Zn(2+)-binding site. Histidine 150-160 solute carrier family 6 member 3 Homo sapiens 97-117 10601246-2 1999 Recently, we have described a distance constraint in the unknown tertiary structure of the human dopamine transporter (hDAT) by identification of two histidines, His(193) in the second extracellular loop and His(375) at the top of transmembrane (TM) 7, that form two coordinates in an endogenous, high affinity Zn(2+)-binding site. Histidine 150-160 solute carrier family 6 member 3 Homo sapiens 119-123 10601246-2 1999 Recently, we have described a distance constraint in the unknown tertiary structure of the human dopamine transporter (hDAT) by identification of two histidines, His(193) in the second extracellular loop and His(375) at the top of transmembrane (TM) 7, that form two coordinates in an endogenous, high affinity Zn(2+)-binding site. Histidine 162-165 solute carrier family 6 member 3 Homo sapiens 97-117 10601246-2 1999 Recently, we have described a distance constraint in the unknown tertiary structure of the human dopamine transporter (hDAT) by identification of two histidines, His(193) in the second extracellular loop and His(375) at the top of transmembrane (TM) 7, that form two coordinates in an endogenous, high affinity Zn(2+)-binding site. Histidine 162-165 solute carrier family 6 member 3 Homo sapiens 119-123 10601246-2 1999 Recently, we have described a distance constraint in the unknown tertiary structure of the human dopamine transporter (hDAT) by identification of two histidines, His(193) in the second extracellular loop and His(375) at the top of transmembrane (TM) 7, that form two coordinates in an endogenous, high affinity Zn(2+)-binding site. Histidine 208-211 solute carrier family 6 member 3 Homo sapiens 97-117 10601246-2 1999 Recently, we have described a distance constraint in the unknown tertiary structure of the human dopamine transporter (hDAT) by identification of two histidines, His(193) in the second extracellular loop and His(375) at the top of transmembrane (TM) 7, that form two coordinates in an endogenous, high affinity Zn(2+)-binding site. Histidine 208-211 solute carrier family 6 member 3 Homo sapiens 119-123 10601246-8 1999 The common participation of Glu(396), His(193), and His(375) in binding the small Zn(2+) ion implies their proximity in the unknown tertiary structure of hDAT. Histidine 38-41 solute carrier family 6 member 3 Homo sapiens 154-158 10601246-8 1999 The common participation of Glu(396), His(193), and His(375) in binding the small Zn(2+) ion implies their proximity in the unknown tertiary structure of hDAT. Histidine 52-55 solute carrier family 6 member 3 Homo sapiens 154-158 10658591-5 1999 The amino acids found to be important for MDL103,392 binding to the NK-2 receptor are Gln-166, His-198, Tyr-266 and Tyr-289. Histidine 95-98 tachykinin receptor 2 Homo sapiens 68-81 10574744-3 1999 The peptide sequence for Drosophila leucokinin (DLK) was determined as Asn-Ser-Val-Val-Leu-Gly-Lys-Lys-Gln-Arg-Phe-His-Ser-Trp-Gly-amide, making it the longest member of the family characterized to date. Histidine 115-118 Leucokinin Drosophila melanogaster 36-46 10574744-3 1999 The peptide sequence for Drosophila leucokinin (DLK) was determined as Asn-Ser-Val-Val-Leu-Gly-Lys-Lys-Gln-Arg-Phe-His-Ser-Trp-Gly-amide, making it the longest member of the family characterized to date. Histidine 115-118 Leucokinin Drosophila melanogaster 48-51 10578014-25 1999 Mechanisms of H(+) permeation through gp91-phox include the possible protonation/deprotonation of His-115 as it is exposed alternatively to the interior and exterior faces of the cell membrane (see Starace, D.M., E. Stefani, and F. Bezanilla. Histidine 98-101 cytochrome b-245 beta chain Homo sapiens 38-47 10567440-4 1999 The antigen was recombinant hTS containing an N-terminal His(6)-tag. Histidine 57-60 APC down-regulated 1 Homo sapiens 28-31 10625445-4 1999 The displacement from an interface with cytochrome c(1) in native crystals to an interface with cytochrome b is induced by stigmatellin or 5-n-undecyl-6-hydroxy-4,7-dioxobenzothiazole (UHDBT) and involves ligand formation between His-161 of the [2Fe-2S] binding cluster and the inhibitor. Histidine 230-233 CYTB Gallus gallus 96-108 10551831-0 1999 Proton transfer from histidine 244 may facilitate the 1,2 rearrangement reaction in coenzyme B(12)-dependent methylmalonyl-CoA mutase. Histidine 21-30 methylmalonyl-CoA mutase Homo sapiens 109-133 10525531-6 1999 Recombinant GST-Kap122p formed a complex with recombinant His(6)-Toa1p/Toa2p. Histidine 58-61 Kap122p Saccharomyces cerevisiae S288C 16-23 10525531-6 1999 Recombinant GST-Kap122p formed a complex with recombinant His(6)-Toa1p/Toa2p. Histidine 58-61 transcription initiation factor IIA subunit gamma Saccharomyces cerevisiae S288C 71-76 20402667-2 2010 Here, we have characterized a novel USP44 (ubiquitin-specific protease 44), which has a ZnF-UBP (zinc-finger ubiquitin-specific protease) domain and conserved cysteine, histidine and asparagine/aspartic acid residues characteristic of deubiquitinating enzymes. Histidine 169-178 ubiquitin specific peptidase 44 Mus musculus 43-73 20361220-3 2010 Previous studies suggested that the first step of the dioxygenase reaction involves the deprotonation of the indoleamine group of the substrate by an evolutionarily conserved distal histidine residue in TDO and the heme-bound dioxygen in IDO. Histidine 182-191 tryptophan 2,3-dioxygenase Homo sapiens 203-206 20361220-5 2010 Our data suggest that the deprotonation of the indoleamine group of the substrate by either histidine in TDO or heme-bound dioxygen in IDO is not energetically favorable. Histidine 92-101 tryptophan 2,3-dioxygenase Homo sapiens 105-108 20645695-6 2010 The major action of PAP is to dephosphorylate macromolecules with the help of catalytic residues (His(12) and Asp(258)) that are located in the cleft between two domains. Histidine 98-101 acid phosphatase 3 Homo sapiens 20-23 10510299-8 1999 Competition experiments with positively charged poly(amino acids) furthermore suggested that histidine, arginine and lysine residues in LPL are important for the interaction between LDL and LPL. Histidine 93-102 lipoprotein lipase Mus musculus 136-139 10510299-8 1999 Competition experiments with positively charged poly(amino acids) furthermore suggested that histidine, arginine and lysine residues in LPL are important for the interaction between LDL and LPL. Histidine 93-102 lipoprotein lipase Mus musculus 190-193 10582345-1 1999 Basic Kruppel-like Factor (BKLF) is a recently recognized member of a small group of transcription factors that bind CACCC motifs in DNA, by means of three highly conserved C-terminal Kruppel-like (typically Cys-X2-4-Cys-X12-His-X3-4-His) zinc fingers. Histidine 234-237 Kruppel-like factor 3 (basic) Mus musculus 0-25 10582345-1 1999 Basic Kruppel-like Factor (BKLF) is a recently recognized member of a small group of transcription factors that bind CACCC motifs in DNA, by means of three highly conserved C-terminal Kruppel-like (typically Cys-X2-4-Cys-X12-His-X3-4-His) zinc fingers. Histidine 234-237 Kruppel-like factor 3 (basic) Mus musculus 27-31 21558190-17 2010 The unique features of STC2, including 14 instead of 11 cysteines and a cluster of histidines in the C-terminal region, appear to be found exclusively in vertebrates. Histidine 83-93 stanniocalcin 2 Homo sapiens 23-27 20463099-7 2010 RESULTS: DNA sequence analysis revealed an A to C transversion at codon 502 of GCMB, which altered the wild-type asparagine (Asn) to histidine (His). Histidine 133-142 glial cells missing transcription factor 2 Homo sapiens 79-83 20463099-7 2010 RESULTS: DNA sequence analysis revealed an A to C transversion at codon 502 of GCMB, which altered the wild-type asparagine (Asn) to histidine (His). Histidine 144-147 glial cells missing transcription factor 2 Homo sapiens 79-83 20811567-3 2010 The essential HIS3 gene from the histidine biosynthesis pathway was placed under the exclusive regulation of the galactose utilization system. Histidine 33-42 imidazoleglycerol-phosphate dehydratase HIS3 Saccharomyces cerevisiae S288C 14-18 20047315-8 2010 The electronic properties of the hemes in the reduced state of TDO change significantly upon L-Trp addition, which is attributed to a change in the protonation state of the proximal histidine to the hemes. Histidine 182-191 tryptophan 2,3-dioxygenase Homo sapiens 63-66 20047315-13 2010 This work presents a new description of the heme interactions with the protein, and with the proximal His, which must be considered during the general interpretation of physical data as it relates to kinetics, mechanism, and function of TDO. Histidine 102-105 tryptophan 2,3-dioxygenase Homo sapiens 237-240 20180985-4 2010 CNPase was expressed in E. coli with a TEV-cleavable His-tag. Histidine 53-56 2',3'-cyclic nucleotide 3' phosphodiesterase Mus musculus 0-6 10605835-9 1999 The crystal structure of a spectroscopically similar sample of CCP (MKT) (lambda CT = 637 nm) solved at 2.0 A resolution is consistent with His/hydroxide coordination. Histidine 140-143 cytochrome-c peroxidase Saccharomyces cerevisiae S288C 63-66 10605835-10 1999 Alkaline CCP (pH 9.7) is proposed to exist as a mixture of hexa-coordinate, predominantly low-spin complexes with distal His 52 and hydroxide acting as distal ligands based on MCD spectral comparisons. Histidine 121-124 cytochrome-c peroxidase Saccharomyces cerevisiae S288C 9-12 10493777-5 1999 RESULTS: Sorbinil binds to the active site of aldehyde reductase and is hydrogen-bonded to Trp 22, Tyr 50, His 113, and the non-conserved Arg 312. Histidine 107-110 aldo-keto reductase family 1 member A1 Homo sapiens 46-64 10610126-4 1999 In this study, we characterized, in vitro, the putative cytokinin-responsive CKI1 His-kinase, in terms of His-Asp phosphorelays. Histidine 82-85 casein kinase I Arabidopsis thaliana 77-81 10493588-1 1999 The extracellular portions of the chains that comprise the human type I interferon receptor, IFNAR1 and IFNAR2, have been expressed and purified as recombinant soluble His-tagged proteins, and their interactions with each other and with human interferon-beta-1a (IFN-beta-1a) were studied by gel filtration and by cross-linking. Histidine 168-171 interferon alpha and beta receptor subunit 2 Homo sapiens 104-110 10441372-4 1999 We identified a target molecule of SHP-1 by comparing the phosphorylation of major cellular substrates following in vitro phosphorylation of Jurkat cell lysates in the presence and absence of the His-CytKIR in this cell-free model system. Histidine 196-199 protein tyrosine phosphatase non-receptor type 6 Homo sapiens 35-40 10441372-5 1999 The His-CytKIR was tyrosine phosphorylated by Lck in vitro, and the phosphorylated His-CytKIR recruited SHP-1. Histidine 4-7 protein tyrosine phosphatase non-receptor type 6 Homo sapiens 104-109 10441372-7 1999 However, PLC-gamma exhibited no decrease in phosphorylation when SHP-1 or Lck was depleted or deficient in this reaction mixture, suggesting that the SHP-1 recruited by the phosphorylated His-CytKIR directly mediate the dephosphorylation of PLC-gamma. Histidine 188-191 protein tyrosine phosphatase non-receptor type 6 Homo sapiens 150-155 10409731-1 1999 Mutations in SSY1 and PTR3 were identified in a genetic selection for components required for the proper uptake and compartmentalization of histidine in Saccharomyces cerevisiae. Histidine 140-149 Ssy1p Saccharomyces cerevisiae S288C 13-17 10409731-1 1999 Mutations in SSY1 and PTR3 were identified in a genetic selection for components required for the proper uptake and compartmentalization of histidine in Saccharomyces cerevisiae. Histidine 140-149 Ptr3p Saccharomyces cerevisiae S288C 22-26 10409731-7 1999 ssy1 and ptr3 mutants have increased vacuolar pools of histidine and arginine and exhibit altered cell growth morphologies accompanied by exaggerated invasive growth. Histidine 55-64 Ssy1p Saccharomyces cerevisiae S288C 0-4 10409731-7 1999 ssy1 and ptr3 mutants have increased vacuolar pools of histidine and arginine and exhibit altered cell growth morphologies accompanied by exaggerated invasive growth. Histidine 55-64 Ptr3p Saccharomyces cerevisiae S288C 9-13 10383764-5 1999 VirB4 also dimerized in Agrobacterium tumefaciens, as demonstrated by the recovery of a detergent-resistant complex of native protein and a functional, histidine-tagged derivative by precipitation with anti-His6 antibodies and by Co2+ affinity chromatography. Histidine 152-161 type IV secretion system protein VirB4 Agrobacterium tumefaciens 0-5 19486361-7 2010 RESULTS: The frequencies of ADH2 Arg/His genotype and of ADH2 His allele were significantly lower in patients with migraine when compared with those of controls, and were unrelated with the age of onset of migraine attacks, family history of migraine or presence of aura. Histidine 37-40 alcohol dehydrogenase 1B (class I), beta polypeptide Homo sapiens 28-32 21077763-0 2010 Hb East Timor [beta80(EF4)Asn His, AAC>CAC (HBB c.241A>C)], a variant hemoglobin associated with normal hematology. Histidine 30-33 GTP binding elongation factor GUF1 Homo sapiens 22-25 21077763-3 2010 The variant is due to a missense mutation at amino acid codon 80 (AAC>CAC) which results in the substitution of histidine for asparagine. Histidine 115-124 carbonic anhydrase 2 Homo sapiens 73-76 19918057-6 2009 Despite the lack of a DFG motif, ATP binding to haspin is similar to that in classical kinases; however, the ATP gamma-phosphate forms hydrogen bonds with the conserved catalytic loop residues Asp-649 and His-651, and a His651Ala haspin mutant is inactive, suggesting a direct role for the catalytic loop in ATP recognition. Histidine 205-208 histone H3 associated protein kinase Homo sapiens 48-54 19567267-2 2009 The encoded recombinant hOCTN1 resulted in a 6-His tagged fusion protein with a 34 or 21 amino acid extra N-terminal sequence in the pET-28a(+)-hOCTN1 or in the pH6EX3-hOCTN1 constructs, respectively. Histidine 47-50 solute carrier family 22 member 4 Homo sapiens 24-30 20641508-4 2004 GRP and BN share an identical C-terminal region (-Trp-Ala-Val-Gly-His-Leu-Met-NH2) which is necessary for receptor binding and signal transduction (56). Histidine 66-69 gastrin releasing peptide Homo sapiens 0-3 19715344-8 2009 Taken together, our analytical, spectroscopic, and mutagenesis data indicate that Grx3/4 and Fra2 form a Fe-S-bridged heterodimeric complex with Fe ligands provided by the active site cysteine of Grx3/4, glutathione, and a histidine residue. Histidine 223-232 monothiol glutaredoxin GRX3 Saccharomyces cerevisiae S288C 82-88 19715344-8 2009 Taken together, our analytical, spectroscopic, and mutagenesis data indicate that Grx3/4 and Fra2 form a Fe-S-bridged heterodimeric complex with Fe ligands provided by the active site cysteine of Grx3/4, glutathione, and a histidine residue. Histidine 223-232 Bol2p Saccharomyces cerevisiae S288C 93-97 19715344-8 2009 Taken together, our analytical, spectroscopic, and mutagenesis data indicate that Grx3/4 and Fra2 form a Fe-S-bridged heterodimeric complex with Fe ligands provided by the active site cysteine of Grx3/4, glutathione, and a histidine residue. Histidine 223-232 monothiol glutaredoxin GRX3 Saccharomyces cerevisiae S288C 82-86 19851015-2 2009 An apo IL-3A dUTPase with an amino-terminal T7 epitope tag and a carboxy-terminal histidine tag yielded cubic P2(1)3 crystals with unit-cell parameter a = 106.65 A. Histidine 82-91 Deoxyuridine triphosphatase Drosophila melanogaster 13-20 19549924-0 2009 Heparan sulfate promotes the aggregation of HDL-associated serum amyloid A: evidence for a proamyloidogenic histidine molecular switch. Histidine 108-117 serum amyloid A1 cluster Homo sapiens 59-74 10386883-3 1999 A single-chain form of the NS3/NS4A complex (His-NS4A21-32-GSGS-NS3-631) was constructed in which the NS4A core peptide is fused to the N-terminus of the NS3 protease domain as previously described (Taremi et al., 1998). Histidine 45-48 KRAS proto-oncogene, GTPase Homo sapiens 27-30 10386883-3 1999 A single-chain form of the NS3/NS4A complex (His-NS4A21-32-GSGS-NS3-631) was constructed in which the NS4A core peptide is fused to the N-terminus of the NS3 protease domain as previously described (Taremi et al., 1998). Histidine 45-48 KRAS proto-oncogene, GTPase Homo sapiens 64-67 10386883-3 1999 A single-chain form of the NS3/NS4A complex (His-NS4A21-32-GSGS-NS3-631) was constructed in which the NS4A core peptide is fused to the N-terminus of the NS3 protease domain as previously described (Taremi et al., 1998). Histidine 45-48 KRAS proto-oncogene, GTPase Homo sapiens 64-67 10329662-7 1999 The transcriptional repression function of AEBP2 was completely abolished when one of the conserved histidine residues and a flanking serine residue in the middle zinc finger were replaced with an arginine residue. Histidine 100-109 AE binding protein 2 Mus musculus 43-48 10329662-9 1999 Moreover, both the wild-type and mutant derivative of either the histidine-tagged recombinant AEBP2 proteins or the in vitro translated Gal4-AEBP2 fusion proteins were equally able to bind to the target DNA. Histidine 65-74 AE binding protein 2 Mus musculus 94-99 10228174-2 1999 We have determined the solution structure of human eIF1 with an N-terminal His tag using NMR spectroscopy. Histidine 75-78 eukaryotic translation initiation factor 1 Homo sapiens 51-55 10322033-1 1999 The deduced product of the Bacillus subtilis ytvP gene is similar to that of ORF13, a gene of unknown function in the Lactococcus lactis histidine biosynthesis operon. Histidine 137-146 hypothetical protein Bacillus subtilis 77-82 10206982-1 1999 Currents through the human skeletal muscle chloride channel hClC-1 can be blocked by external application of 1 mM Zn2+ or the histidine-reactive compound diethyl pyrocarbonate (DEPC). Histidine 126-135 chloride voltage-gated channel 1 Homo sapiens 60-66 10096879-3 1999 Using a human methemoglobin alpha beta dimer, it has been shown that at 235 K after 61 ps, a rearrangement occurs in the alpha-chain corresponding to the formation of a bond with the distal histidine. Histidine 190-199 hemoglobin subunit gamma 2 Homo sapiens 14-27 10199784-1 1999 We produced substantial amount of the extracellular domain of the human TSH receptor (TSHRE) that has a tag of six histidines at C-terminus as a soluble form in the human cell line HeLa using a vaccinia virus system. Histidine 115-125 thyroid stimulating hormone receptor Homo sapiens 72-84 10199784-1 1999 We produced substantial amount of the extracellular domain of the human TSH receptor (TSHRE) that has a tag of six histidines at C-terminus as a soluble form in the human cell line HeLa using a vaccinia virus system. Histidine 115-125 thyroid stimulating hormone receptor Homo sapiens 86-91 19685901-0 2009 Transition path sampling study of the conformational fluctuation of His-64 in human carbonic anhydrase II. Histidine 68-71 carbonic anhydrase 2 Homo sapiens 84-105 19685901-1 2009 We report here a transition path sampling study of the conformational fluctuation of His-64 that is known to be important in the enzymatic catalysis of human carbonic anhydrase II. Histidine 85-88 carbonic anhydrase 2 Homo sapiens 158-179 19553567-2 2009 Homology models constructed on the basis of the experimental structures of Escherichia coli AmtB and Nitrosomonas europaea Rh50 indicated a channel structure for human RhA (RhAG), RhB (RhBG), and RhC (RhCG) glycoproteins in which external and internal vestibules are linked by a pore containing two strictly conserved histidines. Histidine 318-328 Rh family B glycoprotein Homo sapiens 180-183 19553567-2 2009 Homology models constructed on the basis of the experimental structures of Escherichia coli AmtB and Nitrosomonas europaea Rh50 indicated a channel structure for human RhA (RhAG), RhB (RhBG), and RhC (RhCG) glycoproteins in which external and internal vestibules are linked by a pore containing two strictly conserved histidines. Histidine 318-328 Rh family B glycoprotein Homo sapiens 185-189 19157633-8 2009 The polymorphism of XPG 46His/His was found to be associated with clinical response in NSCLC patients P=0.047, not detected between chemotherapy response and SNPs of XRCC1 399Arg/Gln or XPG 1104His/Asp (P=0.997 0.561, respectively). Histidine 26-29 ERCC excision repair 5, endonuclease Homo sapiens 20-23 19590015-3 2009 Mutation of an active site His-105 in PGAM5 abolished phosphatase activity with ASK1 and phospho-Thr peptides as substrates. Histidine 27-30 Serine/threonine-protein phosphatase Pgam5, mitochondrial Caenorhabditis elegans 38-43 19580749-4 2009 Histidine 328 in the S4 of Kv12.1 favors binding of Zn2+ and Cd2+, whereas the homologous residue Serine 321 in Kv10.2 contributes to effects of Mg2+ and Ni2+. Histidine 0-9 potassium voltage-gated channel subfamily H member 8 Homo sapiens 27-33 19662275-3 2009 Exchange of the Cys-S-S-Cys bridge by the His-Cu(II)-His motif is very promising, because the resulting complexes retain topological similarity to the native S-S bridged AVP and OXT at pH values corresponding to the physiological pH. Histidine 42-45 oxytocin/neurophysin I prepropeptide Homo sapiens 178-181 19662275-3 2009 Exchange of the Cys-S-S-Cys bridge by the His-Cu(II)-His motif is very promising, because the resulting complexes retain topological similarity to the native S-S bridged AVP and OXT at pH values corresponding to the physiological pH. Histidine 53-56 oxytocin/neurophysin I prepropeptide Homo sapiens 178-181 19332149-2 2009 Mutations in the phylogenetically conserved histidine 127 of the SDHC subunit have been shown to abrogate heme binding in yeast and bacteria without impairing complex II assembly or enzymatic activities. Histidine 44-53 succinate dehydrogenase complex subunit C Homo sapiens 65-69 19568421-7 2009 Site-directed mutagenesis demonstrated that His(127), Asp(156) and Ser(263) in Domain 1 form the catalytic triad of EspP. Histidine 44-47 extracellular serine protease (autotransporter) Escherichia coli 116-120 10201402-5 1999 The enzyme contains a lipase-like catalytic triad, Ser 202, Asp 308 and His 338, consistent with mutational studies that implicate the homologous Ser 424, Asp 693 and His 723 in the catalytic triad in human HSL. Histidine 72-75 lipase E, hormone sensitive type Homo sapiens 207-210 10201402-5 1999 The enzyme contains a lipase-like catalytic triad, Ser 202, Asp 308 and His 338, consistent with mutational studies that implicate the homologous Ser 424, Asp 693 and His 723 in the catalytic triad in human HSL. Histidine 167-170 lipase E, hormone sensitive type Homo sapiens 207-210 10392722-4 1999 A histidine (His6) tag was introduced close to the C-terminus of the proteinase to aid purification. Histidine 2-11 endogenous retrovirus group K member 19, envelope Homo sapiens 69-79 10233272-6 1999 Here, we report the first mutation in the 2B domain of KRT9, 1362ins3, leading to an insertion of histidine in the helix termination motif of the K9 polypeptide. Histidine 98-107 keratin 9 Homo sapiens 55-59 10233272-6 1999 Here, we report the first mutation in the 2B domain of KRT9, 1362ins3, leading to an insertion of histidine in the helix termination motif of the K9 polypeptide. Histidine 98-107 keratin 9 Homo sapiens 146-148 10029536-8 1999 This shift results in the loss of the hydrogen bond between His 162 and Glu 296 seen in the H91N and turkey delta I crystallin structures; this H-bond is believed to be crucial for the catalytic mechanism of ASL/delta II crystallin. Histidine 60-63 argininosuccinate lyase Meleagris gallopavo 208-211 10021468-7 1999 Our results demonstrate that the A-V node and the His-Purkinje regions of the conduction system are specifically compromised by DMPK loss. Histidine 50-53 dystrophia myotonica-protein kinase Mus musculus 128-132 9882312-2 1999 The F13L protein contains a variant of the HKD (His-Lys-Asp) motif, which is conserved in numerous enzymes of phospholipid metabolism. Histidine 48-51 palmytilated EEV membrane glycoprotein Vaccinia virus 4-8 10051705-2 1999 Histamine is synthesized by L-histidine, catalysed by L-histidine decarboxylase (HDC) and metabolized mainly by histamine N-methyltransferase (HMT). Histidine 28-39 histamine N-methyltransferase Homo sapiens 112-141 10051705-2 1999 Histamine is synthesized by L-histidine, catalysed by L-histidine decarboxylase (HDC) and metabolized mainly by histamine N-methyltransferase (HMT). Histidine 28-39 histamine N-methyltransferase Homo sapiens 143-146 10234805-8 1999 An N-cadherin peptidomimic containing the His-Ala-Val sequence to abrogate homotypic N-cadherin interactions inhibited chondrogenesis in a concentration-dependent manner. Histidine 42-45 cadherin 2 Mus musculus 3-13 9860943-10 1998 By using a fumagillin analog tagged with fluorescein, His-231 in MetAP2 was identified as the residue that is covalently modified by fumagillin. Histidine 54-57 methionyl aminopeptidase 2 Homo sapiens 65-71 9860943-11 1998 Site-directed mutagenesis of His-231 demonstrated its importance for the catalytic activity of MetAP2 and confirmed that the same residue is covalently modified by fumagillin. Histidine 29-32 methionyl aminopeptidase 2 Homo sapiens 95-101 9836590-12 1998 It was concluded from these studies that secretin may be stored in a hexameric form within its secretory tissues and that zinc may play a role in the storage of secretin through a specific interaction with the N-terminal histidine and aspartic acid residues. Histidine 221-230 secretin Homo sapiens 161-169 19473029-5 2009 Substitution of His in MTII also provided functional selectivity for the hMC3R or the hMC4R. Histidine 16-19 melanocortin 4 receptor Homo sapiens 86-91 19397338-8 2009 An N-terminal His-tagged version of human Mia40, a resident oxidoreductase of the IMS and a putative physiological reductant of lfALR, was subcloned and expressed in Escherichia coli BL21 DE3 cells. Histidine 14-17 coiled-coil-helix-coiled-coil-helix domain containing 4 Homo sapiens 42-47 19419181-1 2009 We report the selective, controlled binding of a model redox probe, 1,1"-bis(N-imidazolylmethyl)ferrocene (Fc-Im2), and a small redox hemoprotein, histidine-tagged recombinant human neuroglobin (hNb), at the surface of metal electrodes (gold and SER-active silver) modified by a self-assembled monolayer (SAM) of a nitrilotriacetic (NTA)-terminated thiol. Histidine 147-156 neuroglobin Homo sapiens 182-193 19248787-7 2009 Intracardiac evaluation of the atria-His (AH) and His-ventricle (HV) intervals representing supra and infra-Hisian conduction yielded significant acceleration of supra-Hisian conductivity in Cx30.2(LacZ/LacZ) (AH: 28.2+/-4.3 ms) and prolongation of infra-Hisian conduction in Cx40(-/-) mice (HV: 13.7+/-2.6 ms). Histidine 37-40 gap junction protein, delta 3 Mus musculus 191-197 19351145-2 2009 The gold nanorod-bombesin (GNR-BBN) conjugates showed extraordinary in vitro stabilities against various biomolecules including NaCl, cysteine, histidine, bovine serum albumin, human serum albumin, and dithiothreitol. Histidine 144-153 gastrin releasing peptide Homo sapiens 17-25 9880037-3 1998 This variant contains only three instead of the usual five copies of a short peptide repeat [Pro-Gln/His-Gly-Gly-Gly-(Gly)-TrpGly-Gln] characteristic of PrP, with an additional Trp to Gly substitution in codon 102. Histidine 101-104 major prion protein Capra hircus 153-156 9806833-5 1998 FKBP23 is a glycoprotein retained in the endoplasmic reticulum by its carboxyl-terminal tetrapeptide His-Asp-Glu-Leu, as demonstrated by immunostaining, retention, and deglycosylation assays. Histidine 101-104 FK506 binding protein 7 Mus musculus 0-6 9829702-5 1998 These include the conserved Theta class residues Arg 107, Trp 115, and the conserved GSTT1 subclass residue His 176. Histidine 108-111 glutathione S-transferase theta 1 Homo sapiens 85-90 9812898-3 1998 A 1.8 A resolution crystal structure of free and inhibited human MetAP-2 shows a covalent bond formed between a reactive epoxide of fumagillin and histidine-231 in the active site of MetAP-2. Histidine 147-156 methionyl aminopeptidase 2 Homo sapiens 65-72 9812898-3 1998 A 1.8 A resolution crystal structure of free and inhibited human MetAP-2 shows a covalent bond formed between a reactive epoxide of fumagillin and histidine-231 in the active site of MetAP-2. Histidine 147-156 methionyl aminopeptidase 2 Homo sapiens 183-190 9924333-7 1998 Each proband had a homozygous G-->A transition at codon 124, replacing Arg-->His, of the keratoepithelin gene. Histidine 83-86 transforming growth factor beta induced Homo sapiens 95-110 9822825-3 1998 Unexpectedly, most other naturally occurring L-amino acids found in proteins (with the exception of proline, lysine, arginine and histidine) have the same effect on the expression of BAP3. Histidine 130-139 amino acid transporter BAP3 Saccharomyces cerevisiae S288C 183-187 19351145-2 2009 The gold nanorod-bombesin (GNR-BBN) conjugates showed extraordinary in vitro stabilities against various biomolecules including NaCl, cysteine, histidine, bovine serum albumin, human serum albumin, and dithiothreitol. Histidine 144-153 gastrin releasing peptide Homo sapiens 31-34 19552893-9 2009 Moreover, our transgenic assays demonstrate that the N-terminus of the mosquito REL2, which includes the His/Gln-rich and serine-rich regions, plays a role in its transactivation properties. Histidine 105-108 nuclear factor NF-kappa-B p110 subunit Aedes aegypti 80-84 9831037-4 1998 We have introduced a histidine residue into antibody Jel 103 and converted it into an abzyme that cleaves poly(rI) with a kinetic efficiency of about 100 M(-1) sec(-1). Histidine 21-30 secretory blood group 1, pseudogene Homo sapiens 160-166 9786917-3 1998 We report here that CBP, which was originally identified as a co-activator of CREB, directly binds to the b-ZIP region of ATF-2 via a Cys/His-rich region termed C/H2, and potentiates trans-activation by ATF-2. Histidine 138-141 cAMP responsive element binding protein 1 Homo sapiens 78-82 9786917-3 1998 We report here that CBP, which was originally identified as a co-activator of CREB, directly binds to the b-ZIP region of ATF-2 via a Cys/His-rich region termed C/H2, and potentiates trans-activation by ATF-2. Histidine 138-141 death associated protein kinase 3 Homo sapiens 108-111 9786917-3 1998 We report here that CBP, which was originally identified as a co-activator of CREB, directly binds to the b-ZIP region of ATF-2 via a Cys/His-rich region termed C/H2, and potentiates trans-activation by ATF-2. Histidine 138-141 activating transcription factor 2 Homo sapiens 122-127 9756920-7 1998 In contrast to ACAT1 and similar to liver esterification, the activity of ARGP2 was relatively resistant to a histidine active site modifier. Histidine 110-119 sterol O-acyltransferase 2 Homo sapiens 74-79 9753294-3 1998 The DQB1 homolog in NOD mice, I-Ab(g7), encodes a histidine at codon 56 and a serine at codon 57, while all other known I-Ab alleles encode proline and aspartic acid, respectively, at these positions. Histidine 50-59 major histocompatibility complex, class II, DQ beta 1 Homo sapiens 4-8 18831041-10 2009 The amino acids at CD4 and E14 differ between bovine and the fish Hbs and have the potential to modulate oxidative degradation by altering the orientation of the distal histidine and the stability of the E-helix. Histidine 169-178 CD4 molecule Bos taurus 19-22 18926804-11 2009 Furthermore, RDH-E2 expressed in Sf9 insect cells as a fusion to the C-terminal His(6)-tag and purified using Ni(2+)-affinity chromatography recognizes all-trans-retinol and all-trans-retinaldehyde as substrates and exhibits a strong preference for NAD(+)/NADH as cofactors. Histidine 80-83 short chain dehydrogenase/reductase family 16C member 5 Homo sapiens 13-19 19129463-6 2009 OATP1C1 is lacking a highly conserved histidine in the third transmembrane domain, which was shown by site-directed mutagenesis to be critically involved in the pH dependency of OATPs/Oatps. Histidine 38-47 solute carrier organic anion transporter family member 1C1 Homo sapiens 0-7 19052917-9 2009 On the basis of the presence of the several endogenous His residues and glycosylation moieties in CXCR1 we fractionated the detergent-solubilized plasma membranes by employing Ni- and Concanavalin A-based chromatography. Histidine 55-58 C-X-C motif chemokine receptor 1 Homo sapiens 98-103 9856476-6 1998 Reverse transcription/polymerase chain reaction and sequence analysis revealed a C to T transition replacing histidine at amino acid position 101 (His101) by tyrosine in gp91-phox. Histidine 109-118 cytochrome b-245 beta chain Homo sapiens 170-179 9687495-6 1998 A single non-conserved histidine residue (His193) in the large second extracellular loop (ECL2) of hDAT was discovered to be responsible for this difference. Histidine 23-32 solute carrier family 6 member 3 Homo sapiens 99-103 19202543-5 2009 Zinc activates TRPA1 through a unique mechanism that requires zinc influx through TRPA1 channels and subsequent activation via specific intracellular cysteine and histidine residues. Histidine 163-172 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 15-20 9749675-7 1998 In addition, when His-90 in IIA(Glc) was replaced by glutamine, both phosphorylation of IIA(Glc) and the overproduction of cAMP in crp cells were eliminated. Histidine 18-21 catabolite gene activator protein Escherichia coli 131-134 19202543-5 2009 Zinc activates TRPA1 through a unique mechanism that requires zinc influx through TRPA1 channels and subsequent activation via specific intracellular cysteine and histidine residues. Histidine 163-172 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 82-87 19002498-5 2009 It was overexpressed as approximately 50 kDa His-tag fusion protein, and ATP hydrolysis assay of recombinant enzyme showed that either ATP or dATP was required for the unwinding activity, indicating BmL3-helicase as an ATP/dATP-dependent RNA helicase. Histidine 45-48 DEAD-box helicase 19A Homo sapiens 238-250 9677386-3 1998 Sequencing of the cDNA coding for this protein revealed that it is the chicken homologue of formiminotransferase cyclodeaminase (FTCD), a liver-specific enzyme involved in the histidine degradation pathway. Histidine 176-185 formimidoyltransferase cyclodeaminase Gallus gallus 92-127 9677386-3 1998 Sequencing of the cDNA coding for this protein revealed that it is the chicken homologue of formiminotransferase cyclodeaminase (FTCD), a liver-specific enzyme involved in the histidine degradation pathway. Histidine 176-185 formimidoyltransferase cyclodeaminase Gallus gallus 129-133 9655916-5 1998 When His-58 (non-conserved basic residue with DNA-binding potential in the same helical region) was changed to a Gln, the mutated protein was able to protect the ICR from DNase I digestion. Histidine 5-8 DNase I Xenopus laevis 171-178 9723890-4 1998 In contrast to STC-1, the predicted amino acid sequence of STC-2 contains a cluster of histidine residues in the C-terminal portion of the protein, which suggests that STC-2 may interact with metal ions. Histidine 87-96 stanniocalcin 2 Homo sapiens 59-64 9723890-4 1998 In contrast to STC-1, the predicted amino acid sequence of STC-2 contains a cluster of histidine residues in the C-terminal portion of the protein, which suggests that STC-2 may interact with metal ions. Histidine 87-96 stanniocalcin 2 Homo sapiens 168-173 19178182-7 2009 Those amino acid side chains involved in binding the dTDP-sugar into the active site include Tyr 183, His 309, and Tyr 310 from subunit 1 and Lys 219 from subunit 2. Histidine 102-105 TAR DNA-binding protein-43 homolog Drosophila melanogaster 53-57 19135030-2 2009 Amino-acid sequencing analysis reveals that meprin A and meprin alpha cleave pro-IL-1beta at the His(115)-Asp(116) bond, which is one amino acid N-terminal to the caspase-1 cleavage site and five amino acids C-terminal to the meprin beta site. Histidine 97-100 meprin 1 alpha Mus musculus 44-52 19135030-2 2009 Amino-acid sequencing analysis reveals that meprin A and meprin alpha cleave pro-IL-1beta at the His(115)-Asp(116) bond, which is one amino acid N-terminal to the caspase-1 cleavage site and five amino acids C-terminal to the meprin beta site. Histidine 97-100 meprin 1 alpha Mus musculus 57-69 18983266-4 2009 We show using purified His(6)-tagged Rab11 protein and beta2AR intracellular domains fused to GST (glutathione transferase) that Rab11 interacts directly with the C-terminal tail of beta2AR, but not with the other intracellular domains of the receptor. Histidine 23-26 adrenoceptor beta 2 Homo sapiens 182-189 19074135-0 2009 Mutation of histidine 105 in the T1 domain of the potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4. Histidine 12-21 potassium voltage-gated channel subfamily B member 1 Homo sapiens 68-73 19074135-3 2009 In Kv6.x channels the histidine residue of the zinc ion-coordinating C3H1 motif of Kv2.1 is replaced by arginine or valine. Histidine 22-31 potassium voltage-gated channel subfamily B member 1 Homo sapiens 83-88 19074135-4 2009 Using a yeast two-hybrid assay, we found that substitution of the corresponding histidine 105 in Kv2.1 by valine (H105V) or arginine (H105R) disrupted the interaction of the T1 domain of Kv2.1 with the T1 domains of both Kv6.3 and Kv6.4, whereas interaction of the T1 domain of Kv2.1 with itself was unaffected by this mutation. Histidine 80-89 potassium voltage-gated channel subfamily B member 1 Homo sapiens 97-102 19074135-4 2009 Using a yeast two-hybrid assay, we found that substitution of the corresponding histidine 105 in Kv2.1 by valine (H105V) or arginine (H105R) disrupted the interaction of the T1 domain of Kv2.1 with the T1 domains of both Kv6.3 and Kv6.4, whereas interaction of the T1 domain of Kv2.1 with itself was unaffected by this mutation. Histidine 80-89 potassium voltage-gated channel subfamily B member 1 Homo sapiens 187-192 19074135-4 2009 Using a yeast two-hybrid assay, we found that substitution of the corresponding histidine 105 in Kv2.1 by valine (H105V) or arginine (H105R) disrupted the interaction of the T1 domain of Kv2.1 with the T1 domains of both Kv6.3 and Kv6.4, whereas interaction of the T1 domain of Kv2.1 with itself was unaffected by this mutation. Histidine 80-89 potassium voltage-gated channel subfamily B member 1 Homo sapiens 187-192 19074135-10 2009 Our results suggest that His-105 in the T1 domain of Kv2.1 is required for functional heteromerization with members of the Kv6 subfamily. Histidine 25-28 potassium voltage-gated channel subfamily B member 1 Homo sapiens 53-58 19164517-9 2009 Mutating this residue to histidine induced 2-APB sensitivity of chicken TRPV3 to levels comparable for other TRPV3 orthologs. Histidine 25-34 transient receptor potential cation channel subfamily V member 3 Gallus gallus 72-77 9630626-6 1998 Comparison of isoacidic and isosteric inhibitors reveals that (i) the hydrogen bond of the amide proton to His-48 is crucial for strong PLA2 inhibition, (ii) regardless of the headgroup unsubstituted N-acyl groups result in optimal amide acidity for PLA2 inhibition and (iii) the exceptionally strong inhibition by acetamides and the isosteric fluoroacetamides is due to an additional steric effect. Histidine 107-110 phospholipase A2 group IIA Homo sapiens 136-140 9630626-6 1998 Comparison of isoacidic and isosteric inhibitors reveals that (i) the hydrogen bond of the amide proton to His-48 is crucial for strong PLA2 inhibition, (ii) regardless of the headgroup unsubstituted N-acyl groups result in optimal amide acidity for PLA2 inhibition and (iii) the exceptionally strong inhibition by acetamides and the isosteric fluoroacetamides is due to an additional steric effect. Histidine 107-110 phospholipase A2 group IIA Homo sapiens 250-254 9646941-0 1998 Synergistic activation of soluble guanylate cyclase by YC-1 and carbon monoxide: implications for the role of cleavage of the iron-histidine bond during activation by nitric oxide. Histidine 131-140 RNA binding motif single stranded interacting protein 1 Homo sapiens 55-59 9603385-8 1998 This was a substitution of G to A of the second nucleotide position of codon 124 in the betaig-h3 gene that led to a replacement of histidine for arginine (Arg124His, CGC-->CAC). Histidine 132-141 transforming growth factor beta induced Homo sapiens 88-97 9603385-8 1998 This was a substitution of G to A of the second nucleotide position of codon 124 in the betaig-h3 gene that led to a replacement of histidine for arginine (Arg124His, CGC-->CAC). Histidine 132-141 carbonic anhydrase 2 Homo sapiens 176-179 9535834-7 1998 These new findings lead us to conclude that the formation of the alpha1beta1 contact produces in the beta chain a conformational constraint whereby the distal histidine at position 63 is tilted away slightly from the bound dioxygen, preventing the proton-catalyzed displacement of O-2 by a solvent water molecule. Histidine 159-168 immunoglobulin kappa variable 1D-39 Homo sapiens 281-284 19164517-9 2009 Mutating this residue to histidine induced 2-APB sensitivity of chicken TRPV3 to levels comparable for other TRPV3 orthologs. Histidine 25-34 transient receptor potential cation channel subfamily V member 3 Gallus gallus 109-114 19120358-2 2009 An N-terminal-tat and C-terminal histidine-tagged version of hoxb4 (T-hoxb4-H) showed the highest activity in expanding colony forming cells (CFCs) and long-term culture-initiating cells (LTC-ICs) when used at 50 nmol/l concentration in cell culture. Histidine 33-42 homeobox B4 Homo sapiens 61-66 9592734-3 1998 The recombinant E2 protein contained an aminoterminal tag of six histidines that could be used for purification by the nickel chelate affinity chromatography. Histidine 65-75 ubiquitin conjugating enzyme E2 B Homo sapiens 16-26 9520398-10 1998 Disruption of histone deacetylase activity either by TPX or by direct mutation of a histidine presumed to be in the active site abrogates HDAC1-mediated transcriptional repression of a targeted reporter gene in vivo. Histidine 84-93 histone deacetylase 9 Homo sapiens 14-33 9521736-0 1998 Localization of histidine residues responsible for heme axial ligation in cytochrome b556 of complex II (succinate:ubiquinone oxidoreductase) in Escherichia coli. Histidine 16-25 oxidoreductase Escherichia coli 126-140 19120358-2 2009 An N-terminal-tat and C-terminal histidine-tagged version of hoxb4 (T-hoxb4-H) showed the highest activity in expanding colony forming cells (CFCs) and long-term culture-initiating cells (LTC-ICs) when used at 50 nmol/l concentration in cell culture. Histidine 33-42 homeobox B4 Homo sapiens 70-75 19061898-3 2009 The inhibitor stabilizes the N-terminal domain of NS3p and the substrate-binding site, and correctly aligns catalytic His-Asp residues. Histidine 118-121 KRAS proto-oncogene, GTPase Homo sapiens 50-54 9541395-4 1998 Mutations at any of the four catalytic amino acids His 134, His 252, Glu 78, and Asp 212 drastically reduced the hydrolytic activity of DNase I. Histidine 51-54 deoxyribonuclease 1 Homo sapiens 136-143 9541395-4 1998 Mutations at any of the four catalytic amino acids His 134, His 252, Glu 78, and Asp 212 drastically reduced the hydrolytic activity of DNase I. Histidine 60-63 deoxyribonuclease 1 Homo sapiens 136-143 9485405-5 1998 The side chains of S-peptide residues His-12 and Met-13 contribute a large fraction of the total interface with S-protein. Histidine 38-41 vitronectin Homo sapiens 112-121 20641947-0 2004 (99m)Tc Nitrido(diphosphine)-Cys-beta-Ala-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2 The amphibian bombesin (BBN or BN, a peptide of 14 amino acids) is an analog of human gastrin-releasing peptide (GRP, a peptide of 27 amino acids) that binds to GRP receptors (GRPR) with high affinity and specificity (1, 2). Histidine 62-65 gastrin releasing peptide Homo sapiens 92-100 19272175-3 2009 METHODS: To identify the critical amino acid residues of human EndoG, we replaced the conserved histidine, asparagine, and arginine residues with alanine. Histidine 96-105 endonuclease G Homo sapiens 63-68 19272175-5 2009 RESULTS: Diethyl pyrocarbonate modification assay revealed that histidine residues were involved in EndoG activity. Histidine 64-73 endonuclease G Homo sapiens 100-105 19272175-6 2009 His-141, Asn-163, and Asn-172 in the H-N-H motif of EndoG were critical for catalysis and substrate specificity. Histidine 0-3 endonuclease G Homo sapiens 52-57 19088994-4 2009 We study this situation in Human Carbonic Anhydrase II (HCA II) in which one of the three histidines bound to zinc (His119) interacts also with a glutamate residue (Glu117). Histidine 90-100 carbonic anhydrase 2 Homo sapiens 33-54 19139268-2 2009 Using a heterologous expression cloning approach, we isolated beta4GalNAcTB together with beta4GalNAcTB pilot (GABPI), a multimembrane-spanning protein related to Asp-His-His-Cys (DHHC) proteins but lacking the DHHC consensus sequence. Histidine 167-170 beta1,4-N-acetylgalactosaminyltransferase B Drosophila melanogaster 62-75 19139268-2 2009 Using a heterologous expression cloning approach, we isolated beta4GalNAcTB together with beta4GalNAcTB pilot (GABPI), a multimembrane-spanning protein related to Asp-His-His-Cys (DHHC) proteins but lacking the DHHC consensus sequence. Histidine 167-170 beta1,4-N-acetylgalactosaminyltransferase B Drosophila melanogaster 90-103 19117199-10 2009 Kinetic data of the present study supported our recently published findings [using single step-solid phase radioimmunoassay (SS-SPRIA)] that the core region of a conformation-specific epitope of hCGbeta consists of Arg (94, 95) and Asp (99) while a Lys (104) and a His (106) are in proximity to the core epitopic region. Histidine 265-268 chorionic gonadotropin subunit beta 3 Homo sapiens 195-202 18848840-7 2008 Compared with individuals carrying genotypes of hOGG1 326Cys/Cys and hMYH 324His/His at the same time, there was a 0.33-fold (OR(adj), 0.33; 95% CI: 0.15-0.72; P<0.05) decreased risk of CBP for those with genotypes of hOGG1 326Ser/Cys+Ser/Ser and hMYH 324His/Gln+Gln/Gln. Histidine 77-80 mutY DNA glycosylase Homo sapiens 69-73 18848840-7 2008 Compared with individuals carrying genotypes of hOGG1 326Cys/Cys and hMYH 324His/His at the same time, there was a 0.33-fold (OR(adj), 0.33; 95% CI: 0.15-0.72; P<0.05) decreased risk of CBP for those with genotypes of hOGG1 326Ser/Cys+Ser/Ser and hMYH 324His/Gln+Gln/Gln. Histidine 77-80 mutY DNA glycosylase Homo sapiens 250-254 18629440-7 2008 This is the first report on high level expression of hPLSCR1 with histidine tag in E. coli. Histidine 66-75 phospholipid scramblase 1 Homo sapiens 53-60 19012067-8 2008 Kinetic data of the present study supported our recently published findings [using single step-solid phase radioimmunoassay (SS-SPRIA)] that the core region of hCGbeta epitope consists of Arg (94,95) and Asp (99) while a Lys (104) and a His (106) are in proximity to the core epitopic region. Histidine 237-240 chorionic gonadotropin subunit beta 3 Homo sapiens 160-167 18937046-4 2008 We have expressed the mature form of human DMGDH and the H109R variant identified in a DMGDH-deficient patient as N-terminally His(6)-tagged proteins in E. coli. Histidine 127-130 dimethylglycine dehydrogenase Homo sapiens 43-48 9540798-6 1998 These assays showed that chymotrypsin and elastase cleave pNiXa at the P1-P1 (Thr-Lys) peptide bond near the C-terminus, while trypsin and cathepsin G cleave pNiXa at specific peptide bonds near the N-terminus, within an interesting 26-residue segment, rich in Lys and Gln, that separates the His-cluster of pNiXa from the rest of the molecule. Histidine 293-296 cathepsin G Bos taurus 139-150 9516042-5 1998 We submit that histidine clusters, residing both in the Alzheimer"s beta-amyloid peptide and in most of the APP/APLP superfamily of proteins, constitute high-affinity binding sites for immobilized metal chelates. Histidine 15-24 amyloid beta precursor like protein 1 Homo sapiens 112-116 9521129-2 1998 We report here the over-expression of KAP in Escherichia coli as an N-terminal His-tagged protein using a modified pET-28a T7-expression vector. Histidine 79-82 cyclin dependent kinase inhibitor 3 Homo sapiens 38-41 9510129-6 1998 A multiple sequence alignment prepared with five mammalian and five invertebrate peroxidases shows complete conservation of Arg 396, as well as residues corresponding to His 239, His 494, and Asn 579 in TPO. Histidine 170-173 thyroid peroxidase Homo sapiens 203-206 9510129-6 1998 A multiple sequence alignment prepared with five mammalian and five invertebrate peroxidases shows complete conservation of Arg 396, as well as residues corresponding to His 239, His 494, and Asn 579 in TPO. Histidine 179-182 thyroid peroxidase Homo sapiens 203-206 9442066-14 1998 273, 2241-2248) and similar data for wild-type and mutant peroxidases of plant and fungal origin suggests (i) a proton-induced conformational change from an inactive BP 1 at neutral pH to a low activity BP 1 form with a functional distal histidine and (ii) a Ca(2+)-induced slow conformational change (at least compared with compound I formation) of this low activity form to a high activity BP 1 with a typical peroxidase reactivity. Histidine 238-247 prx7 Hordeum vulgare 58-68 9442067-6 1998 The key differences between the structures of active horseradish peroxidase C and inactive BP 1 include the orientation of the catalytic distal histidine, disruption of a hydrogen bond between this histidine and a conserved asparagine, and apparent substitution of calcium at the distal cation binding site with sodium at pH 7.5. Histidine 144-153 prx7 Hordeum vulgare 65-75 9442067-6 1998 The key differences between the structures of active horseradish peroxidase C and inactive BP 1 include the orientation of the catalytic distal histidine, disruption of a hydrogen bond between this histidine and a conserved asparagine, and apparent substitution of calcium at the distal cation binding site with sodium at pH 7.5. Histidine 198-207 prx7 Hordeum vulgare 65-75 9427740-3 1998 We have performed a systematic survey of conserved histidines in the last six transmembrane segments of the related polytopic membrane proteins PsaA and PsaB in the green alga Chlamydomonas reinhardtii. Histidine 51-61 photosystem I P700 chlorophyll a apoprotein A2 Chlamydomonas reinhardtii 153-157 9427740-6 1998 Only mutations in the histidines of helix 10 (PsaA-His676 and PsaB-His656) resulted in changes in spectroscopic properties of P700, leading us to conclude that these histidines are most likely the axial ligands to the P700 chlorophylls. Histidine 22-32 photosystem I P700 chlorophyll a apoprotein A2 Chlamydomonas reinhardtii 62-66 9427740-6 1998 Only mutations in the histidines of helix 10 (PsaA-His676 and PsaB-His656) resulted in changes in spectroscopic properties of P700, leading us to conclude that these histidines are most likely the axial ligands to the P700 chlorophylls. Histidine 166-176 photosystem I P700 chlorophyll a apoprotein A2 Chlamydomonas reinhardtii 62-66 10726060-8 1998 Another important feature of the NS3 proteinase is the presence of a tetrahedral zinc-binding site formed by residues Cys-97, Cys-99, Cys-145 and His-149. Histidine 146-149 KRAS proto-oncogene, GTPase Homo sapiens 33-36 9460923-4 1998 This was due to the presence of a histidine tag on the recombinant ORF19 protein preventing immune recognition of the C-terminal amino acids during immunization. Histidine 34-43 succinyl-CoA:glutarate-CoA transferase Homo sapiens 67-72 10100329-5 1998 Variation is also found in the channel lining M2 regions, including the replacement in four subunits of the highly conserved leucine at the 9" position by valine and most notably, the replacement in all ACR-8-like subunits of the highly conserved glutamic acid at the -1" position by histidine. Histidine 284-293 AcetylCholine Receptor Caenorhabditis elegans 203-208 10100329-7 1998 The calculated electrostatic potential energy profile for the M2 region of ACR-8 differs strikingly from that of ACR-16[Ce21] largely due to the presence of histidine at the -1" position, suggesting a possible perturbation of nAChR channel action permeability in the presence of this subunit type. Histidine 157-166 AcetylCholine Receptor Caenorhabditis elegans 75-80 9395474-4 1997 Mutation of the histidine (H43Q) or aspartic acid (D45A) residues of this motif reduced the ability of Csp to stimulate the ATPase activity of mammalian Hsc70. Histidine 16-25 heat shock protein family A (Hsp70) member 8 Homo sapiens 153-158 9354703-0 1997 Functional expression and purification of histidine-tagged rat renal Na/Phosphate (NaPi-2) and Na/Sulfate (NaSi-1) cotransporters. Histidine 42-51 solute carrier family 13 member 1 Rattus norvegicus 107-113 9342405-7 1997 An outstanding feature of Mss11p is that the protein contains regions of 33 asparagine residues interrupted by only three serine residues, and 35 glutamine residues interrupted by a single histidine residue. Histidine 189-198 Mss11p Saccharomyces cerevisiae S288C 26-32 18629612-3 2008 Sod2 was expressed in Saccharomyces cerevisiae with a C-terminal histidine tag under control of the GAL1 promoter. Histidine 65-74 superoxide dismutase SOD2 Saccharomyces cerevisiae S288C 0-4 20641607-12 2004 (177)Lu-AMBA consists of two components: a peptide of eight amino acids that is composed of the seven common amino acids in the C-terminus of BBN/GRP (Trp-Ala-Val-Gly-His-Leu-Met) and a complex of (177)Lu-DOTA attached to the N-terminus of the peptide via a glycyl-4-aminobezoic acid linker. Histidine 167-170 gastrin releasing peptide Homo sapiens 142-149 18641072-2 2008 In the absence of exogenous ligands, the ferric and the ferrous forms of Ngb are both hexacoordinated to the distal and proximal histidines. Histidine 129-139 neuroglobin Homo sapiens 73-76 18815197-6 2008 The molecular modeling suggests that the replacement of the N41 with a histidine (N41H) drastically disturbs the structure of the first portion of GPIbalpha N-terminal, directly involved in von Willebrand factor binding. Histidine 71-80 glycoprotein Ib platelet subunit alpha Homo sapiens 147-156 18767117-4 2008 Surprisingly, Lys, His, and Thr inhibited S6K1 phosphorylation in both murine and bovine mammary cells. Histidine 19-22 ribosomal protein S6 kinase, polypeptide 1 Mus musculus 42-46 18694848-4 2008 Both SMS1 and SMS2 contain two histidines and one aspartic acid which are evolutionary conserved within the lipid phosphate phosphatase superfamily. Histidine 31-41 sphingomyelin synthase 1 Homo sapiens 5-9 19082310-11 2008 The genetic analysis of tumoral DNA revealed point mutations in two different genes: the wild type CAA at codon 61 of N-RAS mutated to CAT, replacing glycine by histidine (G61H) and the normal GCC sequence at codon 623 of the TSHR gene was replaced by TCC, changing the alanine by serine (A623S). Histidine 161-170 NRAS proto-oncogene, GTPase Homo sapiens 118-123 18690709-0 2008 Direct evidence that all three histidine residues coordinate to Cu(II) in amyloid-beta1-16. Histidine 31-40 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Homo sapiens 82-90 18690709-1 2008 We provide direct evidence that all three histidine residues in amyloid-beta 1-16 (Abeta 1-16) coordinate to Cu(II). Histidine 42-51 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Homo sapiens 72-81 18656261-4 2008 (1)H NMR and EPR studies demonstrate that the predominant oxidation state of Fe in ETHE1 is Fe(II), and NMR studies confirm that two histidines are bound to Fe(II). Histidine 133-143 glyoxalase II 3 Arabidopsis thaliana 83-88 18621979-10 2008 In vitro filter-binding assays indicating that histidine-tagged ACBP6 binds phosphatidylcholine, but not phosphatidic acid or lysophosphatidylcholine, further imply a role for ACBP6 in phospholipid metabolism in Arabidopsis, including the possibility of ACBP6 in the cytosolic trafficking of phosphatidylcholine. Histidine 47-56 acyl-CoA-binding protein 6 Arabidopsis thaliana 64-69 18621979-10 2008 In vitro filter-binding assays indicating that histidine-tagged ACBP6 binds phosphatidylcholine, but not phosphatidic acid or lysophosphatidylcholine, further imply a role for ACBP6 in phospholipid metabolism in Arabidopsis, including the possibility of ACBP6 in the cytosolic trafficking of phosphatidylcholine. Histidine 47-56 acyl-CoA-binding protein 6 Arabidopsis thaliana 176-181 18621979-10 2008 In vitro filter-binding assays indicating that histidine-tagged ACBP6 binds phosphatidylcholine, but not phosphatidic acid or lysophosphatidylcholine, further imply a role for ACBP6 in phospholipid metabolism in Arabidopsis, including the possibility of ACBP6 in the cytosolic trafficking of phosphatidylcholine. Histidine 47-56 acyl-CoA-binding protein 6 Arabidopsis thaliana 176-181 18515357-3 2008 Kinetic analysis revealed that substitution of His-110e, which anchors the loop in occluding position, results in 3-fold increased chagasin affinity (Ki for H110A cathepsin B, 0.35 nm) due to an improved association rate (kon, 5 x 10(5) m(-1)s(-1)). Histidine 47-50 cathepsin B Homo sapiens 163-174 20654366-4 1997 Amino acid analysis of the hydrolysed (HC1) protein showed that His and Tyr undergo a dramatic decrease (approx. Histidine 64-67 CYCS pseudogene 39 Homo sapiens 39-42 9278528-2 1997 Protein kinase C (PKC) and calcium and calmodulin-dependent protein kinase type II (CaM KII) phosphorylated a recombinant his-tagged synprint site polypeptide rapidly to a stoichiometry of 3-4 mol of phosphate/mol, whereas cAMP-dependent protein kinase (PKA) and cGMP-dependent protein kinase (PKG) phosphorylated the synprint peptide more slowly to a stoichiometry of <1 mol/mol. Histidine 122-125 protein kinase C, gamma Rattus norvegicus 0-16 9278528-2 1997 Protein kinase C (PKC) and calcium and calmodulin-dependent protein kinase type II (CaM KII) phosphorylated a recombinant his-tagged synprint site polypeptide rapidly to a stoichiometry of 3-4 mol of phosphate/mol, whereas cAMP-dependent protein kinase (PKA) and cGMP-dependent protein kinase (PKG) phosphorylated the synprint peptide more slowly to a stoichiometry of <1 mol/mol. Histidine 122-125 protein kinase C, gamma Rattus norvegicus 18-21 18593109-0 2008 Investigation of the copper binding site and the role of histidine as a ligand in riboflavin binding protein. Histidine 57-66 retinol binding protein 4 Homo sapiens 82-108 18497940-2 2008 Structural analysis showed that Nbla10993 is a novel splicing variant of the ER-associated protein of 140 kDa (ERAP140), which lacks the central acidic as well as the COOH-terminal Cys/His-rich domain. Histidine 185-188 nuclear receptor coactivator 7 Homo sapiens 32-41 18497940-2 2008 Structural analysis showed that Nbla10993 is a novel splicing variant of the ER-associated protein of 140 kDa (ERAP140), which lacks the central acidic as well as the COOH-terminal Cys/His-rich domain. Histidine 185-188 nuclear receptor coactivator 7 Homo sapiens 77-109 18497940-2 2008 Structural analysis showed that Nbla10993 is a novel splicing variant of the ER-associated protein of 140 kDa (ERAP140), which lacks the central acidic as well as the COOH-terminal Cys/His-rich domain. Histidine 185-188 nuclear receptor coactivator 7 Homo sapiens 111-118 18194442-1 2008 Two histidines are known to be essential for zinc potentiation of rat P2X2 receptors, but the chemistry of zinc coordination would suggest that other residues also participate in this zinc-binding site. Histidine 4-14 purinergic receptor P2X 2 Rattus norvegicus 70-74 9306693-3 1997 The HSF1 kinase forms a stable complex with AtHSF1, which can be detected by kinase pull-down assays using a histidine-tagged AtHSF1 substrate. Histidine 109-118 heat shock factor 1 Arabidopsis thaliana 4-8 9306693-3 1997 The HSF1 kinase forms a stable complex with AtHSF1, which can be detected by kinase pull-down assays using a histidine-tagged AtHSF1 substrate. Histidine 109-118 heat shock factor 1 Arabidopsis thaliana 44-50 9306693-3 1997 The HSF1 kinase forms a stable complex with AtHSF1, which can be detected by kinase pull-down assays using a histidine-tagged AtHSF1 substrate. Histidine 109-118 heat shock factor 1 Arabidopsis thaliana 126-132 9464573-6 1997 Histidine tagging of GFP-CNTF permitted ready purification by means of immobilized Ni(II) chromatography. Histidine 0-9 ciliary neurotrophic factor Homo sapiens 25-29 9256424-5 1997 Nm23-H1 also can transfer phosphate from its catalytic histidine to histidines on ATP-citrate lyase and succinic thiokinase. Histidine 55-64 ATP citrate lyase Homo sapiens 82-99 9256424-5 1997 Nm23-H1 also can transfer phosphate from its catalytic histidine to histidines on ATP-citrate lyase and succinic thiokinase. Histidine 68-78 ATP citrate lyase Homo sapiens 82-99 9218440-6 1997 Our previous studies have identified a mutation at position 332 within Drosophila TBP that changes a highly conserved arginine residue to a histidine residue, which renders it specifically defective in its ability to support RNA polymerase III transcription in S-2 cells (Trivedi, A., Vilalta, A., Gopalan, S., and Johnson, D. L. (1996) Mol. Histidine 140-149 df Drosophila melanogaster 189-198 18250167-3 2008 Here, we report a novel K(ATP) channel gating defect caused by CHI-associated Kir6.2 mutations at arginine 301 (to cysteine, glycine, histidine, or proline). Histidine 134-143 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 78-84 17964203-3 2008 Treatment of CAI-4 with UV light yielded histidine auxotrophs which could be complemented by HIS4, suggesting that strain CAI-4 is heterozygous for HIS4. Histidine 41-50 Phosphoribosyl-AMP cyclohydrolase Candida albicans SC5314 148-152 17964203-5 2008 As expected from a heterozygote, disruption of the functional allele of HIS4 resulted in a his4::hisG-URA3-hisG strain that is auxotrophic for histidine. Histidine 143-152 Phosphoribosyl-AMP cyclohydrolase Candida albicans SC5314 72-76 17964203-5 2008 As expected from a heterozygote, disruption of the functional allele of HIS4 resulted in a his4::hisG-URA3-hisG strain that is auxotrophic for histidine. Histidine 143-152 Phosphoribosyl-AMP cyclohydrolase Candida albicans SC5314 91-95 18345016-2 2008 Here we report that two histidine residues, His365 and His394, located in the intracellular regulator of conductance for K+ (RCK) 1 domain, serve as the H+ sensors of the SLO1 BK channel. Histidine 24-33 potassium calcium-activated channel subfamily M alpha 1 Homo sapiens 171-175 18178100-8 2008 FRET analysis showed that his-ACBP directly interacted with HNF-4alpha (intermolecular distance of 73 A) at high affinity (K(d)=64-111 nM) similar to native ACBP. Histidine 26-29 hepatic nuclear factor 4, alpha Mus musculus 60-70 18316727-5 2008 The stimulatory action of CO on the Slo1 BK channel requires an aspartic acid and two histidine residues located in the cytoplasmic RCK1 domain, and the effect persists under the conditions known to inhibit the conventional interaction between CO and heme in other proteins. Histidine 86-95 potassium calcium-activated channel subfamily M alpha 1 Homo sapiens 36-40 18008383-1 2008 Modification of His-47 and removal of the N-terminal octapeptide caused a different effect on the structure of Naja naja atra (Taiwan cobra) phospholipase A2 (PLA2). Histidine 16-19 phospholipase A2 group IIA Homo sapiens 159-163 9211916-9 1997 CobT phosphoribosylated alternative base substrates including benzimidazole, 4,5-dimethyl-1,2-phenylenediamine, imidazole, histidine, adenine, and guanine in vitro. Histidine 123-132 nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 0-4 11669966-1 1997 Copper(III) complexes of Gly(2)HisGly and Aib(2)HisGly are characterized, where Gly is glycine, His is L-histidine, and Aib is alpha-aminoisobutyric acid. Histidine 31-34 ANIB1 Homo sapiens 120-123 11669966-1 1997 Copper(III) complexes of Gly(2)HisGly and Aib(2)HisGly are characterized, where Gly is glycine, His is L-histidine, and Aib is alpha-aminoisobutyric acid. Histidine 103-114 ANIB1 Homo sapiens 42-45 9166854-7 1997 In a Northern blot analysis from homogeneous tissue biopsy from the intradermal injection sites, RANTES was more potent than MCP-1 in increasing histidine decarboxylase (HDC) mRNA, the sole enzyme responsible for the production of histamine from histidine. Histidine 145-154 C-C motif chemokine ligand 5 Rattus norvegicus 97-103 9192170-3 1997 In this study, we report histidine-like immunoreactivity in the rat retina with the use of antibodies raised against histidine coupled to bovine serum albumin (BSA) with glutaraldehyde. Histidine 25-34 albumin Rattus norvegicus 145-158 9266477-1 1997 The structure of neuromedin C, a 10-residue bombesin-like neuropeptide with the sequence Gly-Asn-His-Trp-Ala-Val-Gly-His-Leu-Met-NH2, has been investigated. Histidine 117-120 gastrin releasing peptide Homo sapiens 17-29 9148914-5 1997 A detailed kinetic analysis of AAP5 using lysine, alanine, glutamate, and histidine revealed H+-dependent differences in the apparent affinity constants for each substrate. Histidine 74-83 amino acid permease 5 Arabidopsis thaliana 31-35 9148914-6 1997 The differences were correlated to the effect of H+ concentration on the net charge of each amino acid and suggested that AAP5 transports only the neutral species of histidine and glutamate. Histidine 166-175 amino acid permease 5 Arabidopsis thaliana 122-126 9180275-1 1997 The Candida albicans CAN1 gene, encoding a high-affinity permease for arginine, lysine and histidine, was tagged at its C-terminus with a c-myc epitope and introduced into strains of Saccharomyces cerevisiae lacking basic amino acid permeases. Histidine 91-100 arginine permease CAN1 Saccharomyces cerevisiae S288C 21-25 9092499-5 1997 The isolated GFRP cDNA was expressed in Escherichia coli as a fusion protein with six consecutive histidine residues at its N terminus. Histidine 98-107 GTP cyclohydrolase I feedback regulator Rattus norvegicus 13-17 9119391-10 1997 The two polymorphic GPT isozymes are the results of a nucleotide substitution in codon 14, coding for a histidine in GPT-1 and an asparagine in GPT-2, which causes a gain or loss of an NlaIII restriction site. Histidine 104-113 glutamic--pyruvic transaminase 2 Homo sapiens 144-149 9147644-1 1997 We have generated polyclonal antibodies against the amino-terminal third of the Menkes protein (ATP7A; MNK) by immunizing rabbits with a histidine-tagged MNK fusion construct containing metal-binding domains 1-4. Histidine 137-146 ATPase copper transporting alpha Homo sapiens 103-106 9147644-1 1997 We have generated polyclonal antibodies against the amino-terminal third of the Menkes protein (ATP7A; MNK) by immunizing rabbits with a histidine-tagged MNK fusion construct containing metal-binding domains 1-4. Histidine 137-146 ATPase copper transporting alpha Homo sapiens 154-157 9062474-4 1997 An activating mutation of the TSH receptor gene in both the primary tumor and the lymph node metastasis was found, due to a base substitution at codon 633 (normal guanine at position 1896 replaced by cytosine CAC for GAC causing aspartic acid substitution by histidine). Histidine 259-268 thyroid stimulating hormone receptor Homo sapiens 30-42 9091313-0 1997 Identification of essential aspartic acid and histidine residues of hormone-sensitive lipase: apparent residues of the catalytic triad. Histidine 46-55 lipase E, hormone sensitive type Homo sapiens 68-92 9091313-1 1997 It is expected that hormone-sensitive lipase (HSL), like most other lipases and esterases, adopts an alpha/beta-hydrolase fold and has a catalytic triad of serine, aspartic or glutamic acid, and histidine. Histidine 195-204 lipase E, hormone sensitive type Homo sapiens 20-44 9091313-1 1997 It is expected that hormone-sensitive lipase (HSL), like most other lipases and esterases, adopts an alpha/beta-hydrolase fold and has a catalytic triad of serine, aspartic or glutamic acid, and histidine. Histidine 195-204 lipase E, hormone sensitive type Homo sapiens 46-49 9091313-2 1997 Recently, we have published a three-dimensional model for the C-terminal catalytic domain of HSL, having an alpha/beta-hydrolase fold and with Ser-423(1), Asp-703 and His-733 in the catalytic triad (Contreras et al. Histidine 167-170 lipase E, hormone sensitive type Homo sapiens 93-96 8980679-1 1996 A recA mutant (recA423; Arg169-->His), with properties that should help clarify the relationship between the biochemical properties of RecA protein and its two major functions, homologous genetic recombination and recombinational DNA repair, has been isolated. Histidine 36-39 RAD51 recombinase Homo sapiens 2-6 8980679-1 1996 A recA mutant (recA423; Arg169-->His), with properties that should help clarify the relationship between the biochemical properties of RecA protein and its two major functions, homologous genetic recombination and recombinational DNA repair, has been isolated. Histidine 36-39 RAD51 recombinase Homo sapiens 138-142 8962082-10 1996 In addition, a human FAS cDNA encoding domains II and III (enoyl and beta-ketoacyl reductases, acyl carrier protein, and thioesterase) was cloned in pET-32b(+) and expressed in E. coli as a fusion protein with thioredoxin and six in-frame histidine residues. Histidine 239-248 fatty acid synthase Homo sapiens 21-24 8986225-6 1996 Three different mutations were found in the exon 3 sequence of CCKBR: His (CAT) at aa207-->His (CAC) (5.4%), Arg (CGC) at aa215-->His (CAC) (4.5%), and Val (GTG) at aa138-->Met (ATG) (0.9%) in controls. Histidine 70-73 carbonic anhydrase 2 Homo sapiens 99-102 8972866-2 1996 The histidine-tagged HNF1/1-281 DNA binding domain and nuclear extract from rat liver were used. Histidine 4-13 HNF1 homeobox A Rattus norvegicus 21-25 8910277-3 1996 One mutant of activated human RAC protein, RACV12H40 (with valine and histidine substituted at position 12 and 40, respectively), was defective in binding to PAK3, a Ste20-related p21-activated kinase (PAK), but bound to POR1, a RAC-binding protein. Histidine 70-79 p21 (RAC1) activated kinase 3 Homo sapiens 158-162 18008383-3 2008 Moreover, the spatial positions of Trp residues in His-modified PLA2 were not properly rearranged toward lipid-water interface in the presence of Ca2+. Histidine 51-54 phospholipase A2 group IIA Homo sapiens 64-68 18008383-5 2008 Although a precipitous drop in the enzymatic activity was observed with modified PLA2, His-modified PLA2 and N-terminally truncated PLA2 retained cytotoxicity on inducing necrotic death of human neuroblastoma SK-N-SH cells. Histidine 87-90 phospholipase A2 group IIA Homo sapiens 100-104 18008383-5 2008 Although a precipitous drop in the enzymatic activity was observed with modified PLA2, His-modified PLA2 and N-terminally truncated PLA2 retained cytotoxicity on inducing necrotic death of human neuroblastoma SK-N-SH cells. Histidine 87-90 phospholipase A2 group IIA Homo sapiens 100-104 18220330-1 2008 The tetrapeptide sequence His-Phe-Arg-Trp, derived from melanocyte-stimulating hormone (alphaMSH) and its analogs, causes a decrease in food intake and elevates energy utilization upon binding to the melanocortin-4 receptor (MC4R). Histidine 26-29 melanocortin 4 receptor Rattus norvegicus 200-223 18220330-1 2008 The tetrapeptide sequence His-Phe-Arg-Trp, derived from melanocyte-stimulating hormone (alphaMSH) and its analogs, causes a decrease in food intake and elevates energy utilization upon binding to the melanocortin-4 receptor (MC4R). Histidine 26-29 melanocortin 4 receptor Rattus norvegicus 225-229 20641369-3 2004 Both GRP and BN share an amidated C-terminus sequence homology of seven amino acids, -Trp-Ala-Val-Gly-His-Leu-Met-NH2. Histidine 102-105 gastrin releasing peptide Homo sapiens 5-8 20641835-2 2004 Both GRP and BN share an amidated C-terminus sequence homology of seven amino acids, -Trp-Ala-Val-Gly-His-Leu-Met-NH2. Histidine 102-105 gastrin releasing peptide Homo sapiens 5-8 18574322-1 2008 We recently showed that arginine transport via cationic amino acid transporter 1 (CAT1), which transports arginine, lysine, ornithine, and histidine, is essential for erythropoiesis. Histidine 139-148 solute carrier family 7 member 1 Homo sapiens 47-80 18574322-1 2008 We recently showed that arginine transport via cationic amino acid transporter 1 (CAT1), which transports arginine, lysine, ornithine, and histidine, is essential for erythropoiesis. Histidine 139-148 solute carrier family 7 member 1 Homo sapiens 82-86 18081866-2 2008 Although mammalian Gup1 has a sequence conserved among the membrane-bound O-acyltransferase family, the histidine residue in the motif that is indispensable to the acyltransferase activity of the family has been replaced with leucine. Histidine 104-113 hedgehog acyltransferase like Homo sapiens 19-23 9007276-10 1996 This difference is discussed on basis of modeling, taking in view the difference at position 13, with Arg in pLT and His in hLT. Histidine 117-120 Leucine transport, high Homo sapiens 124-127 17936057-6 2008 Interestingly, the interaction of both isoforms with Shp2 in vivo was found using stable cell lines expressing eEF1A1-His or eEF1A2-His. Histidine 118-121 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 53-57 17936057-6 2008 Interestingly, the interaction of both isoforms with Shp2 in vivo was found using stable cell lines expressing eEF1A1-His or eEF1A2-His. Histidine 132-135 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 53-57 18177606-2 2008 METHODS: A CDS fragment of human syk was obtained by RT-PCR from human breast cancer cells MDA-MB-468 and then the fragment was cloned into the expression vector pcDNA3.1D/V5-His-TOPO. Histidine 175-178 spleen associated tyrosine kinase Homo sapiens 33-36 20641931-0 2004 (99m)Tc-pGlu-Gln-Trp-Ala-Val-Gly-His-Phe-Met-NH2 Bombesin (BBN or BN)-like peptide is an analog of human gastrin-releasing peptide (GRP) that binds to GRP receptors (GRP-R) (1). Histidine 33-36 gastrin releasing peptide Homo sapiens 49-57 20641931-0 2004 (99m)Tc-pGlu-Gln-Trp-Ala-Val-Gly-His-Phe-Met-NH2 Bombesin (BBN or BN)-like peptide is an analog of human gastrin-releasing peptide (GRP) that binds to GRP receptors (GRP-R) (1). Histidine 33-36 gastrin releasing peptide Homo sapiens 105-130 20641931-0 2004 (99m)Tc-pGlu-Gln-Trp-Ala-Val-Gly-His-Phe-Met-NH2 Bombesin (BBN or BN)-like peptide is an analog of human gastrin-releasing peptide (GRP) that binds to GRP receptors (GRP-R) (1). Histidine 33-36 gastrin releasing peptide Homo sapiens 132-135 17962323-4 2007 In the human protein, sequence substitution of tyrosine by histidine at this critical position generated a mutant that displays almost identical proton sensitivity compared with mouse TRESK. Histidine 59-68 potassium channel, subfamily K, member 18 Mus musculus 184-189 8936589-5 1996 To aid purification, the protein was expressed with an amino-terminal extension encoding an initiating methionine and 10 histidine residues followed by an enterokinase cleavage site; 0.3mg of HIS-SRP 54-kDa was purified to give a single band on SDS-PAGE in 20% yield from 500 ml of cultured E. coli. Histidine 192-195 signal recognition particle 54 Canis lupus familiaris 196-202 8885841-3 1996 We have generated mutants of cytochrome b562 in which the histidine ligand to the heme iron (His102) has been replaced by a methionine. Histidine 58-67 mitochondrially encoded cytochrome b Homo sapiens 29-41 8900174-9 1996 Three photo-labeled residues, His-244 (alpha3 helix), Met-308, and Arg-310 (alpha4/beta6 interface), were specifically identified as photoinsertion sites. Histidine 30-33 immunoglobulin binding protein 1 Homo sapiens 76-88 18039930-19 2007 Site-directed mutagenesis of these His residues results in the loss of RIDalpha-RILP interaction and RIDalpha activity in cells. Histidine 35-38 reactive intermediate imine deaminase A homolog Homo sapiens 71-79 18039930-19 2007 Site-directed mutagenesis of these His residues results in the loss of RIDalpha-RILP interaction and RIDalpha activity in cells. Histidine 35-38 reactive intermediate imine deaminase A homolog Homo sapiens 101-109 17924455-8 2007 By metabolome analysis of intracellular compounds, the amount of histidine and arginine is increased, and the amount of threonine, lysine and nicotinic acid is decreased in the Ami1p-overproducing strain as compared with the control, suggesting that Ami1p may hydrolyse some amides related to amino acid and niacin metabolism in the cell. Histidine 65-74 glutathione peroxidase GPX2 Saccharomyces cerevisiae S288C 177-182 17929833-10 2007 The X-ray structure of the human cytosolic MetAP1 showed three Co2+ ions at the active site, with the third Co2+ coordinated by the conserved residue His 212 [Addlagatta, A., Hu, X., Liu, J. O., and Matthews, B. W. (2005) Biochemistry 44, 14741-14749]. Histidine 150-153 methionyl aminopeptidase 1 Homo sapiens 43-49 20641503-3 2004 Both GRP and BN share an amidated C-terminus sequence homology of seven amino acids, -Trp-Ala-Val-Gly-His-Leu-Met-NH2. Histidine 102-105 gastrin releasing peptide Homo sapiens 5-8 8874200-6 1996 Sequence analysis of the Fc gamma RIIIA gene, encoding CD16 on NK cells and macrophages, showed a T to A nucleotide substitution at position 230 on both alleles, predicting a leucine (L) to histidine (H) amino acid change position 48 in the first extracellular lg-like domain of Fc gamma RIIIa, which contains the Leu11c/B73.1 epitope. Histidine 190-199 Fc gamma receptor IIIa Homo sapiens 25-39 8874200-6 1996 Sequence analysis of the Fc gamma RIIIA gene, encoding CD16 on NK cells and macrophages, showed a T to A nucleotide substitution at position 230 on both alleles, predicting a leucine (L) to histidine (H) amino acid change position 48 in the first extracellular lg-like domain of Fc gamma RIIIa, which contains the Leu11c/B73.1 epitope. Histidine 190-199 Fc gamma receptor IIIa Homo sapiens 55-59 8798701-1 1996 The role of the four histidine residues in receptor binding and activity of mouse nerve growth factor (NGF) was investigated using both site-directed mutagenesis and chemical modification with diethyl pyrocarbonate. Histidine 21-30 nerve growth factor Mus musculus 82-101 8798701-1 1996 The role of the four histidine residues in receptor binding and activity of mouse nerve growth factor (NGF) was investigated using both site-directed mutagenesis and chemical modification with diethyl pyrocarbonate. Histidine 21-30 nerve growth factor Mus musculus 103-106 8883261-0 1996 A mutant (Arg327-->His) GPIIb associated to thrombasthenia exerts a dominant negative effect in stably transfected CHO cells. Histidine 22-25 integrin subunit alpha 2b Homo sapiens 27-32 8702754-3 1996 Tris/Tricine/SDS-polyacrylamide gel electrophoresis and immunoblot analyses of histidine-tagged recombinant placentin indicate that it is composed of two peptide chains of apparent molecular masses of 4 and 13 kDa. Histidine 79-88 insulin like 4 Homo sapiens 108-117 8753810-4 1996 Substitution of Cys-16, Cys-31, or His-33 markedly decreased the transforming activity of Rfp/Ret. Histidine 35-38 tripartite motif-containing 27 Mus musculus 90-93 8753810-6 1996 In contrast, mutations of Cys-118 or His-124 in the second cysteine/histidine-rich motif (called B box) of Rfp/Ret did not affect its activity. Histidine 37-40 tripartite motif-containing 27 Mus musculus 107-110 8753810-6 1996 In contrast, mutations of Cys-118 or His-124 in the second cysteine/histidine-rich motif (called B box) of Rfp/Ret did not affect its activity. Histidine 68-77 tripartite motif-containing 27 Mus musculus 107-110 8807898-1 1996 BACKGROUND: The Zn(II)-binding site from the active center of human carbonic anhydrase II, formed by three His side chains, can be grafted onto the recombinant serum retinol-binding protein (RBP). Histidine 107-110 carbonic anhydrase 2 Homo sapiens 68-89 8807898-1 1996 BACKGROUND: The Zn(II)-binding site from the active center of human carbonic anhydrase II, formed by three His side chains, can be grafted onto the recombinant serum retinol-binding protein (RBP). Histidine 107-110 retinol binding protein 4 Homo sapiens 166-189 8807898-1 1996 BACKGROUND: The Zn(II)-binding site from the active center of human carbonic anhydrase II, formed by three His side chains, can be grafted onto the recombinant serum retinol-binding protein (RBP). Histidine 107-110 retinol binding protein 4 Homo sapiens 191-194 8844843-10 1996 The effects of the His 92 Gln and Phe 100 Ala mutations on GpC turnover are additive in the corresponding double mutant, indicating that the contribution of Phe 100 to catalysis is independent of the catalytic acid His 92. Histidine 19-22 glycophorin C (Gerbich blood group) Homo sapiens 59-62 17890311-4 2007 In order to understand the details of the inhibitory mechanism of CIII, we cloned and expressed the protein with an N-terminal six-histidine tag. Histidine 131-140 cIII Escherichia virus Lambda 66-70 8675572-2 1996 We expressed in Chinese hamster ovary cells the human TSHR ectodomain (ECD) with a carboxyl-terminus six-histidine tag. Histidine 105-114 thyroid stimulating hormone receptor Homo sapiens 54-58 17905810-3 2007 We propose that cytochrome b(561) has a specific mechanism to facilitate the concerted proton/electron transfer from ascorbate by exploiting a cycle of deprotonated and protonated states of the N(delta1) atom of the axial His residue at the extravesicular haem center, as an initial step of the transmembrane electron transfer. Histidine 222-225 mitochondrially encoded cytochrome b Homo sapiens 16-28 19517008-3 2007 Several green fluorescent protein (GFP)-fused and histidine (His)-tagged chimeras of ALMT1 were prepared based on a computer-predicted secondary structure and transiently expressed in cultured mammalian cells. Histidine 50-59 aluminum-activated malate transporter 1 Triticum aestivum 85-90 19517008-3 2007 Several green fluorescent protein (GFP)-fused and histidine (His)-tagged chimeras of ALMT1 were prepared based on a computer-predicted secondary structure and transiently expressed in cultured mammalian cells. Histidine 61-64 aluminum-activated malate transporter 1 Triticum aestivum 85-90 17869271-4 2007 Our data demonstrate that exchanging Cys for His and vice versa in the highly conserved Zn-coordinating HCCH motif disrupted Vif function and interaction with Cul5. Histidine 45-48 Vif Human immunodeficiency virus 1 125-128 18071584-7 2007 The RPLP1 gene was overexpressed in E. coli and the result indicated that RPLP1 fusion with the N-terminally His-tagged form gave rise to the accumulation of an expected 18kDa polypeptide, which was in accordance with the predicted protein and could also be used to purify the protein and study its function. Histidine 109-112 60S acidic ribosomal protein P1 Ailuropoda melanoleuca 4-9 17706472-2 2007 An amino-terminal histidine fusion tag was added to hSlo, the human BK channel, and expressed in Sf9 insect cells. Histidine 18-27 potassium calcium-activated channel subfamily M alpha 1 Homo sapiens 52-56 18035827-9 2007 A structural model of FALDH has been constructed, and catalytically important residues have been proposed to be involved in alcohol and aldehyde oxidation: Gln-120, Glu-207, Cys-241, Phe-333, Tyr-410 and His-411. Histidine 204-207 aldehyde dehydrogenase 3 family member A2 Homo sapiens 22-27 17850513-10 2007 Therefore, our model explains the mechanistic necessity for conservation of not only active site histidines but also adjacent amino acids in tyrosinase. Histidine 97-107 tyrosinase Homo sapiens 141-151 17707404-7 2007 The presence of an N-terminal His-tag on PrxIII markedly enhances dodecamer stability, particularly apparent in its oxidised state. Histidine 30-33 peroxiredoxin 3 Homo sapiens 41-47 20641296-2 2004 Both GRP and BN share an amidated C-terminus sequence homology of seven amino acids, -Trp-Ala-Val-Gly-His-Leu-Met-NH2. Histidine 102-105 gastrin releasing peptide Homo sapiens 5-8 17713929-1 2007 To probe the mechanism of the alkaline conformational transition and its effect on the dynamics of gated electron transfer (ET) reactions, a Lys 79 --> His (K79H) variant of iso-1-cytochrome c has been prepared. Histidine 155-158 eukaryotic translation initiation factor 1 Homo sapiens 177-182 17604919-5 2007 frRunx1 had an extra stretch of eight histidine residues, while frRunx2 lacked the poly-glutamine/-alanine stretch that is a hallmark of the mammalian Runx2 genes. Histidine 38-47 runt-related transcription factor 1 Takifugu rubripes 0-7 17691838-1 2007 We investigate the probable proton-transfer pathways from the surface of human carbonic anhydrase II into the active site cavity through His-64 that has been widely implicated as a key residue along the proton-transfer path. Histidine 137-140 carbonic anhydrase 2 Homo sapiens 79-100 17785185-3 2007 N-cadherin antagonistic peptide containing the His-Ala-Val motif (HAV-N) transiently disrupted hippocampal N-cadherin dimerization and impaired the formation of long-term contextual fear memory while sparing short-term memory, retrieval, and extinction. Histidine 47-50 cadherin 2 Homo sapiens 0-10 17785185-3 2007 N-cadherin antagonistic peptide containing the His-Ala-Val motif (HAV-N) transiently disrupted hippocampal N-cadherin dimerization and impaired the formation of long-term contextual fear memory while sparing short-term memory, retrieval, and extinction. Histidine 47-50 cadherin 2 Homo sapiens 107-117 17496029-1 2007 In the cytochrome c-551 family, the heme 17-propionate caboxylate group is always hydrogen bonded to an invariant Trp-56 and conserved residues (His and Arg mainly, Lys occasionally) at position 47. Histidine 145-148 cytochrome c3 family protein Pseudomonas stutzeri 7-19 17572636-6 2007 Protein modeling predicts that substitution with histidine, and only histidine, creates a pH-sensitive switch within the activation domain of the receptor that leads to ligand-independent activation of ACVR1 in fibrodysplasia ossificans progressiva. Histidine 49-58 activin A receptor type 1 Homo sapiens 202-207 17572636-6 2007 Protein modeling predicts that substitution with histidine, and only histidine, creates a pH-sensitive switch within the activation domain of the receptor that leads to ligand-independent activation of ACVR1 in fibrodysplasia ossificans progressiva. Histidine 69-78 activin A receptor type 1 Homo sapiens 202-207 17896967-3 2007 Here we show that 20-200 nM of both N-terminally histidine-tagged recombinant Tat(1-72) and Tat(1-86) stimulated reverse transcription by HIV-1 reverse transcriptase (RT) in vitro by 2-3 fold. Histidine 49-58 Tat Human immunodeficiency virus 1 78-81 17576516-7 2007 Histidine 23 of the archaeal dPGM of T. acidophilum, which corresponds to active site histidine in dPGMs from bacteria and eukarya, was exchanged for alanine by site directed mutagenesis. Histidine 0-9 Phosphoglucose mutase 1 Drosophila melanogaster 29-33 17576516-7 2007 Histidine 23 of the archaeal dPGM of T. acidophilum, which corresponds to active site histidine in dPGMs from bacteria and eukarya, was exchanged for alanine by site directed mutagenesis. Histidine 86-95 Phosphoglucose mutase 1 Drosophila melanogaster 29-33 17710231-4 2007 Mapping of H193R mutation onto the crystal structure of myrosinase, a plant homolog of KL, revealed that this histidine residue was at the base of the deep catalytic cleft and mutation of this histidine to arginine should destabilize the putative glycosidase domain (KL1) of KL, thereby attenuating production of membrane-bound and secreted KL. Histidine 110-119 KIT ligand Homo sapiens 267-270 17710231-4 2007 Mapping of H193R mutation onto the crystal structure of myrosinase, a plant homolog of KL, revealed that this histidine residue was at the base of the deep catalytic cleft and mutation of this histidine to arginine should destabilize the putative glycosidase domain (KL1) of KL, thereby attenuating production of membrane-bound and secreted KL. Histidine 193-202 KIT ligand Homo sapiens 267-270 17768240-3 2007 spdB2 of the conjugative pSVH1 plasmid of Streptomyces venezuelae was heterologously expressed in Escherichia coli and Streptomyces lividans, with a C-terminal His-tag-encoding sequence. Histidine 160-163 SpdB2 protein Streptomyces venezuelae 0-5 20641271-3 2004 Both GRP and BN share an amidated C-terminus sequence homology of 7 amino acids, -Trp-Ala-Val-Gly-His-Leu-Met-NH2. Histidine 98-101 gastrin releasing peptide Homo sapiens 5-8 17306880-1 2007 PURPOSE: To determine the association between complement factor H (CFH) polymorphism T1277C (tyrosine-402 --> histidine-402) and phenotypic variations of age-related macular degeneration (AMD). Histidine 113-122 complement factor H Homo sapiens 46-65 17306880-1 2007 PURPOSE: To determine the association between complement factor H (CFH) polymorphism T1277C (tyrosine-402 --> histidine-402) and phenotypic variations of age-related macular degeneration (AMD). Histidine 113-122 complement factor H Homo sapiens 67-70 17306880-12 2007 CONCLUSIONS: Complement factor H polymorphism T1277C (tyrosine-402 --> histidine-402) is strongly associated with both dry and wet AMD and points to a possible role for inflammation in the pathogenesis of AMD. Histidine 74-83 complement factor H Homo sapiens 13-32 17629352-1 2007 beta-Lactotensin (His-Ile-Arg-Leu) is an ileum-contracting tetrapeptide isolated from bovine beta-lactoglobulin. Histidine 18-21 beta-lactoglobulin Bos taurus 93-111 17372332-2 2007 Recently, we characterized a mutant, G420H, which replaced glycine 420 in the extracellular domain of SR-BI with a histidine residue and had a profound effect on SR-BI function. Histidine 115-124 scavenger receptor class B member 1 Homo sapiens 102-107 16882456-1 2007 In a previous work, we identified a Cys(2)/His(2)-type zinc-finger transcription repressor, (ZFT1), that functions in a spermine-mediated signal transduction pathway in tobacco plants. Histidine 43-46 zinc finger protein ZAT10-like Nicotiana tabacum 93-97 17307731-4 2007 Analysis of single-site mutants of the TSG-6 Link module indicated that the loss in affinity above pH 6.0 is mediated by the change in ionization state of a histidine residue (His(4)) that is not within the HA-binding site. Histidine 157-166 TNF alpha induced protein 6 Homo sapiens 39-44 17307731-4 2007 Analysis of single-site mutants of the TSG-6 Link module indicated that the loss in affinity above pH 6.0 is mediated by the change in ionization state of a histidine residue (His(4)) that is not within the HA-binding site. Histidine 176-179 TNF alpha induced protein 6 Homo sapiens 39-44 17460754-5 2007 By assessing cell viability with the MTT reduction assay, we found that salsolinol exhibited a selective toxicity toward OCT2-expressing cells that was prevented by cyclo(his-pro). Histidine 171-174 POU class 2 homeobox 2 Homo sapiens 121-125 17460754-6 2007 A frequent genetic variant of OCT2 with the amino acid substitution R400C reduced the transport efficiency for the cytoprotective cyclo(his-pro) and thereby increased the susceptibility to salsolinol-induced cell death. Histidine 136-139 POU class 2 homeobox 2 Homo sapiens 30-34 17460754-7 2007 CONCLUSIONS/SIGNIFICANCE: Our findings indicate that the OCT2-regulated interplay between cyclo(his-pro) and salsolinol is crucial for nigral cell integrity and that a shift in transport efficiency may impact the risk of Parkinson"s disease. Histidine 96-99 POU class 2 homeobox 2 Homo sapiens 57-61 17293598-2 2007 When histidine instead of tyrosine is present at position 384 in the seventh complement control protein (CCP) domain of FH, the risk for age-related macular degeneration is increased. Histidine 5-14 complement factor H Homo sapiens 120-122 17267065-4 2007 Here, we synthesized a novel pH-sensitive histidine-modified galactosylated cholesterol derivative (Gal-His-C4-Chol), for a more efficient gene delivery to hepatocytes. Histidine 42-51 galanin and GMAP prepropeptide Homo sapiens 100-103 17398321-3 2007 Recently, a complement factor H (CFH) polymorphism, which is characterized by a tyrosine (Y)-to-histidine (H) exchange at position 402 of the CFH gene, has been suggested as a major risk factor for AMD in a North American population. Histidine 96-105 complement factor H Homo sapiens 12-31 17398321-3 2007 Recently, a complement factor H (CFH) polymorphism, which is characterized by a tyrosine (Y)-to-histidine (H) exchange at position 402 of the CFH gene, has been suggested as a major risk factor for AMD in a North American population. Histidine 96-105 complement factor H Homo sapiens 33-36 17398321-3 2007 Recently, a complement factor H (CFH) polymorphism, which is characterized by a tyrosine (Y)-to-histidine (H) exchange at position 402 of the CFH gene, has been suggested as a major risk factor for AMD in a North American population. Histidine 96-105 complement factor H Homo sapiens 142-145 17207559-4 2007 Histidine(4), tyrosine(5), tryptophan(6), histidine(7)-TIP39 binds the PTH2 receptor with high affinity, has over 30-fold selectivity for the rat PTH2 receptor over the rat PTH1 receptor and displays no detectable agonist activity. Histidine 0-9 parathyroid hormone 2 receptor Rattus norvegicus 71-84 17207559-4 2007 Histidine(4), tyrosine(5), tryptophan(6), histidine(7)-TIP39 binds the PTH2 receptor with high affinity, has over 30-fold selectivity for the rat PTH2 receptor over the rat PTH1 receptor and displays no detectable agonist activity. Histidine 0-9 parathyroid hormone 2 receptor Rattus norvegicus 146-159 17207559-4 2007 Histidine(4), tyrosine(5), tryptophan(6), histidine(7)-TIP39 binds the PTH2 receptor with high affinity, has over 30-fold selectivity for the rat PTH2 receptor over the rat PTH1 receptor and displays no detectable agonist activity. Histidine 0-9 parathyroid hormone 1 receptor Rattus norvegicus 173-186 17207559-4 2007 Histidine(4), tyrosine(5), tryptophan(6), histidine(7)-TIP39 binds the PTH2 receptor with high affinity, has over 30-fold selectivity for the rat PTH2 receptor over the rat PTH1 receptor and displays no detectable agonist activity. Histidine 42-51 parathyroid hormone 2 receptor Rattus norvegicus 71-84 17207559-4 2007 Histidine(4), tyrosine(5), tryptophan(6), histidine(7)-TIP39 binds the PTH2 receptor with high affinity, has over 30-fold selectivity for the rat PTH2 receptor over the rat PTH1 receptor and displays no detectable agonist activity. Histidine 42-51 parathyroid hormone 2 receptor Rattus norvegicus 146-159 17207559-4 2007 Histidine(4), tyrosine(5), tryptophan(6), histidine(7)-TIP39 binds the PTH2 receptor with high affinity, has over 30-fold selectivity for the rat PTH2 receptor over the rat PTH1 receptor and displays no detectable agonist activity. Histidine 42-51 parathyroid hormone 1 receptor Rattus norvegicus 173-186 17202139-1 2007 The imidazole (15)N signals of histidine 64 (His(64)), involved in the catalytic function of human carbonic anhydrase II (hCAII), were assigned unambiguously. Histidine 31-40 carbonic anhydrase 2 Homo sapiens 99-120 17202139-1 2007 The imidazole (15)N signals of histidine 64 (His(64)), involved in the catalytic function of human carbonic anhydrase II (hCAII), were assigned unambiguously. Histidine 31-40 carbonic anhydrase 2 Homo sapiens 122-127 17202139-1 2007 The imidazole (15)N signals of histidine 64 (His(64)), involved in the catalytic function of human carbonic anhydrase II (hCAII), were assigned unambiguously. Histidine 45-48 carbonic anhydrase 2 Homo sapiens 99-120 17202139-1 2007 The imidazole (15)N signals of histidine 64 (His(64)), involved in the catalytic function of human carbonic anhydrase II (hCAII), were assigned unambiguously. Histidine 45-48 carbonic anhydrase 2 Homo sapiens 122-127 17234634-4 2007 The purified native or N-terminal His-tagged recombinant rat RCL protein expressed in Escherichia coli exhibits the same enzyme activity, deoxynucleoside 5"-monophosphate N-glycosidase, never before described. Histidine 34-37 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 Rattus norvegicus 61-64 17290983-6 2007 The effective nodal plane of low-spin NP1, NP4, and NP2 complexes is in all cases of imidazole and histamine complexes quite similar to the average of the His-59 or -57 and the exogenous ligand angles seen in the X-ray crystal structures. Histidine 155-158 neuropilin 2 Homo sapiens 52-55 17202136-0 2007 A histidine-rich cluster mediates the ubiquitination and degradation of the human zinc transporter, hZIP4, and protects against zinc cytotoxicity. Histidine 2-11 solute carrier family 39 member 4 Homo sapiens 100-105 17239391-4 2007 In contrast cysteine 922 (within NS2) is only required for NS2/3 auto-cleavage activity and histidine 1175 is only required for NS3 activity. Histidine 92-101 KRAS proto-oncogene, GTPase Homo sapiens 128-131 17088264-9 2007 The inhibition profile of a tyrosine kinase, Abl (a histidine-tagged recombinant mouse Abl kinase), was determined using the substrate Abltide-GST (a fusion protein consisting of a specific substrate peptide for Abl and glutathione S-transferase) and the approved drug Glivec (an ATP competitor). Histidine 52-61 c-abl oncogene 1, non-receptor tyrosine kinase Mus musculus 45-48 17088264-9 2007 The inhibition profile of a tyrosine kinase, Abl (a histidine-tagged recombinant mouse Abl kinase), was determined using the substrate Abltide-GST (a fusion protein consisting of a specific substrate peptide for Abl and glutathione S-transferase) and the approved drug Glivec (an ATP competitor). Histidine 52-61 c-abl oncogene 1, non-receptor tyrosine kinase Mus musculus 87-90 17088264-9 2007 The inhibition profile of a tyrosine kinase, Abl (a histidine-tagged recombinant mouse Abl kinase), was determined using the substrate Abltide-GST (a fusion protein consisting of a specific substrate peptide for Abl and glutathione S-transferase) and the approved drug Glivec (an ATP competitor). Histidine 52-61 c-abl oncogene 1, non-receptor tyrosine kinase Mus musculus 87-90 17200862-4 2007 In this complex, NDPK B acts as a protein histidine kinase phosphorylating Gbeta at histidine residue 266 (His266). Histidine 42-51 cytidine/uridine monophosphate kinase 1 Rattus norvegicus 17-21 17217471-6 2007 Histidine-tagged Arabidopsis PMM (AtPMM) purified from Escherichia coli converted mannose-1-phosphate into mannose-6-phosphate and glucose-1-phosphate into glucose-6-phosphate, with the former reaction being more efficient than the latter one. Histidine 0-9 phosphomannomutase Arabidopsis thaliana 29-32 17244493-0 2007 Protective effects of histidine dipeptides on the modification of neurofilament-L by the cytochrome c/hydrogen peroxide system. Histidine 22-31 neurofilament light chain Homo sapiens 66-81 17244493-4 2007 In the present study, we investigated whether histidine dipeptides, carnosine, homocarnosine, or anserine protect NF-L against oxidative modification during reaction between cytochrome c and H(2)O(2). Histidine 46-55 neurofilament light chain Homo sapiens 114-118 17469229-3 2007 The protein was expressed in Escherichia coli with or without an N-terminal His-tag and had functional DASPO activity that was highly specific for D-aspartate and N-methyl-D-aspartate. Histidine 76-79 D-aspartate oxidase Mus musculus 103-108 17469229-4 2007 To investigate the roles of the Arg-216 and Arg-237 residues of the mouse DASPO (mDASPO), we generated clones with several single amino acid substitutions of these residues in an N-terminally His-tagged mDASPO. Histidine 192-195 D-aspartate oxidase Mus musculus 74-79 17066390-1 2007 In the present study the importance of the active site histidine residue (His) for the activity of epoxide- or aziridine-based cysteine protease inhibitors is examined theoretically. Histidine 55-64 cathepsin B Homo sapiens 127-144 17066390-1 2007 In the present study the importance of the active site histidine residue (His) for the activity of epoxide- or aziridine-based cysteine protease inhibitors is examined theoretically. Histidine 74-77 cathepsin B Homo sapiens 127-144 17324336-6 2007 Importantly, we observed linkage among polymorphisms within and between FcgammaRIIa and FcgammaRIIIa, including the expression of histidine at FcgammaRIIa-131 and valine at FcgammaRIIIa, both of which are associated with enhanced responses to rituximab. Histidine 130-139 Fc gamma receptor IIIa Homo sapiens 88-100 18401441-3 2007 Specifically, we have expressed and purified the catalytic kinase domain of PDK1 with an N-terminal histidine tag [His(6)-PDK1(DeltaPH)]. Histidine 100-109 pyruvate dehydrogenase kinase 1 Homo sapiens 76-80 18401441-3 2007 Specifically, we have expressed and purified the catalytic kinase domain of PDK1 with an N-terminal histidine tag [His(6)-PDK1(DeltaPH)]. Histidine 100-109 pyruvate dehydrogenase kinase 1 Homo sapiens 122-126 18401441-3 2007 Specifically, we have expressed and purified the catalytic kinase domain of PDK1 with an N-terminal histidine tag [His(6)-PDK1(DeltaPH)]. Histidine 115-118 pyruvate dehydrogenase kinase 1 Homo sapiens 76-80 18401441-3 2007 Specifically, we have expressed and purified the catalytic kinase domain of PDK1 with an N-terminal histidine tag [His(6)-PDK1(DeltaPH)]. Histidine 115-118 pyruvate dehydrogenase kinase 1 Homo sapiens 122-126 18401441-5 2007 The supramolecular association of the BODIPY-ATP dyad with the His(6)-PDK1(DeltaPH)-QD assembly encourages the transfer of energy from the QDs to the BODIPY dyes upon excitation. Histidine 63-66 pyruvate dehydrogenase kinase 1 Homo sapiens 70-74 16981206-3 2006 Three L-arginine-metal coordination interactions are found in metalloenzyme structures deposited in the Protein Data Bank: biotin synthase from E. coli, His-67 --> Arg human carbonic anhydrase I, and inactivated B. caldovelox arginase complexed with L-arginine. Histidine 153-156 carbonic anhydrase 1 Homo sapiens 177-197 16989765-9 2006 Bioinformatic analyses indicate that histidine 158 is an evolutionarily conserved residue in most vertebrate TIMP homologs and predict that substitution by arginine disrupts TIMP3 function. Histidine 37-46 TIMP metallopeptidase inhibitor 3 Homo sapiens 174-179 17029360-0 2006 Metal-binding thermodynamics of the histidine-rich sequence from the metal-transport protein IRT1 of Arabidopsis thaliana. Histidine 36-45 iron-regulated transporter 1 Arabidopsis thaliana 93-97 17029360-6 2006 Although Fe2+ and other IRT1-transported metal ions do not bind very tightly, this His-rich sequence has a very high entropy-driven affinity for Fe3+, which may have biological significance. Histidine 83-86 iron-regulated transporter 1 Arabidopsis thaliana 24-28 16828555-7 2006 Accordingly, site-directed mutagenesis of Gln-148 of 15-PGDH to alanine, glutamic acid, histidine, and asparagine (Q148A, Q148E, Q148H, and Q148N) was carried out. Histidine 88-97 carbonyl reductase 1 Homo sapiens 53-60 16844077-1 2006 The proteins from the ZIP and the CDF families of zinc transporters contain a histidine-rich sequence in a loop domain located between transmembrane domains III and IV for the ZIP family and transmembrane domains IV and V for the CDF family. Histidine 78-87 death associated protein kinase 3 Homo sapiens 22-25 16844077-1 2006 The proteins from the ZIP and the CDF families of zinc transporters contain a histidine-rich sequence in a loop domain located between transmembrane domains III and IV for the ZIP family and transmembrane domains IV and V for the CDF family. Histidine 78-87 death associated protein kinase 3 Homo sapiens 176-179 16972175-21 2006 Analysis of the FH gene revealed the maternally derived c.1029_1031delAGT mutation, resulting in Val deletion and substitution of Gln by His, and paternally derived c.976C > T mutation, resulting in substitution of Pro by Ser. Histidine 137-140 fumarate hydratase Homo sapiens 16-18 17121011-4 2006 The recombinant protein NASP was purified from the supernatant with Ni2 -NTA His-bind resin under native conditions. Histidine 77-80 nuclear autoantigenic sperm protein Homo sapiens 24-28 16756512-10 2006 We also present evidence that histidine and aspartic acid residues in the Lag motif are essential for the function of Lag1p in vivo. Histidine 30-39 sphingosine N-acyltransferase LAG1 Saccharomyces cerevisiae S288C 118-123 16835243-1 2006 Hint1 is a member of the evolutionarily conserved family of histidine triad proteins that acts as a haplo-insufficient tumor suppressor inducing spontaneous tumor formation in Hint+/- and Hint-/- mouse models. Histidine 60-69 histidine triad nucleotide binding protein 1 Mus musculus 0-5 16835243-1 2006 Hint1 is a member of the evolutionarily conserved family of histidine triad proteins that acts as a haplo-insufficient tumor suppressor inducing spontaneous tumor formation in Hint+/- and Hint-/- mouse models. Histidine 60-69 histidine triad nucleotide binding protein 1 Mus musculus 0-4 16835243-1 2006 Hint1 is a member of the evolutionarily conserved family of histidine triad proteins that acts as a haplo-insufficient tumor suppressor inducing spontaneous tumor formation in Hint+/- and Hint-/- mouse models. Histidine 60-69 histidine triad nucleotide binding protein 1 Mus musculus 176-180 16893175-4 2006 Plant hxHbs contain a conserved Phe at position B10 (Phe(B10)), which is near the reversibly coordinated distal His(E7). Histidine 112-115 ectonucleotide pyrophosphatase/phosphodiesterase 3 Homo sapiens 48-51 16893175-4 2006 Plant hxHbs contain a conserved Phe at position B10 (Phe(B10)), which is near the reversibly coordinated distal His(E7). Histidine 112-115 ectonucleotide pyrophosphatase/phosphodiesterase 3 Homo sapiens 57-60 16878944-1 2006 Methods to fine-tune the rate of a fast conformational electron transfer (ET) gate involving a His-heme alkaline conformer of iso-1-cytochrome c (iso-1-Cytc) and to adjust the pH accessibility of a slow ET gate involving a Lys-heme alkaline conformer are described. Histidine 95-98 eukaryotic translation initiation factor 1 Homo sapiens 146-156 16644091-0 2006 A density functional theory study on the role of His-107 in arylamine N-acetyltransferase 2 acetylation. Histidine 49-52 N-acetyltransferase 2 Homo sapiens 60-91 17083198-7 2006 The recombinant plasmid pET28a/mIL-21 with a carboxyl terminal His-tag was subcloned from the pcDNA3.1/mIL-21 and expressed in E. coli. Histidine 63-66 interleukin 21 Mus musculus 31-37 16684569-1 2006 The normally hexa coordinate ferrous form of neuroglobin binds CO by replacement of the heme-linked distal histidine residue. Histidine 107-116 neuroglobin Homo sapiens 45-56 16629640-0 2006 Evidence for allosteric regulation of pH-sensitive System A (SNAT2) and System N (SNAT5) amino acid transporter activity involving a conserved histidine residue. Histidine 143-152 solute carrier family 38 member 2 Homo sapiens 61-66 16714405-7 2006 This shortfall in our basic understanding of AtPCS1 is addressed here by the results of systematic site-directed mutagenesis studies that demonstrate that not only Cys-56 but also His-162 and Asp-180 are indeed required for net PC synthesis. Histidine 180-183 Eukaryotic aspartyl protease family protein Arabidopsis thaliana 45-51 16749776-11 2006 The fastest catalyst was the threonine mutant A3C ((Ac-His-Thr)8(Dap-His-Thr)4(Dap-His-Thr)2Dap-His-Thr-NH2), with kcat = 1.3 min(-1), kcat/k(uncat) = 90"000, KM = 160 microM for 8-bytyryloxypyrene 1,3,6-trisulfonate, corresponding to a rate acceleration of 18"000 per catalytic site and a 5-fold improvement over the original sequence A3. Histidine 55-58 apolipoprotein B mRNA editing enzyme catalytic subunit 3C Homo sapiens 46-49 16332725-4 2006 The ADH2 Arg allele was found to be associated with increased risk, the odds ratios (ORs) being 1.35 (95% confidence interval: 1.00-1.84) and 1.93 (1.06-3.53) for the His/Arg and Arg/Arg genotypes, respectively. Histidine 167-170 alcohol dehydrogenase 1B (class I), beta polypeptide Homo sapiens 4-8 16702384-5 2006 ADH2 His/Arg and Arg/Arg genotypes showed higher risk for habitual drinking. Histidine 5-8 alcohol dehydrogenase 1B (class I), beta polypeptide Homo sapiens 0-4 16784457-2 2006 A variety of dicarboxylic acid linkers introduced between the alpha-amino group of His(6) and the epsilon-amino group of Lys(10) lead to high-affinity, selective human melanocortin receptor-1 and -5 (hMC1R and hMC5R) antagonists. Histidine 83-86 melanocortin 5 receptor Homo sapiens 210-215 16511838-5 2006 One novel missense variant in exon 4, derived from the nucleotide transition in codon 162 (CGT --> CAT:485G > A) resulting in an arginine-to-histidine (Arg --> His) change, was detected in these subjects. Histidine 141-150 UDP glycosyltransferase 8 Homo sapiens 91-94 16511838-5 2006 One novel missense variant in exon 4, derived from the nucleotide transition in codon 162 (CGT --> CAT:485G > A) resulting in an arginine-to-histidine (Arg --> His) change, was detected in these subjects. Histidine 160-163 UDP glycosyltransferase 8 Homo sapiens 91-94 17283967-19 2006 This indicates both that supportive cells are metabolically less active than feather-producing cells, and that putative histidine-rich proteins are only present in cells synthesizing feather keratin. Histidine 120-129 keratin Gallus gallus 191-198 16717448-6 2006 For ANXA9 one SNP was located in exon 5 (A-->G 951) resulting in an amino acid change from histidine to arginine. Histidine 94-103 annexin A9 Bos taurus 4-9 16918475-5 2006 The determination of the X-ray crystal structure of NAT from Salmonella typhimurium led to the identification of the catalytically essential triad of residues: Cys-His-Asp, which is present in all functional NAT enzymes. Histidine 164-167 bromodomain containing 2 Homo sapiens 52-55 16918475-5 2006 The determination of the X-ray crystal structure of NAT from Salmonella typhimurium led to the identification of the catalytically essential triad of residues: Cys-His-Asp, which is present in all functional NAT enzymes. Histidine 164-167 bromodomain containing 2 Homo sapiens 208-211 16121393-8 2006 In contrast to the wild-type and EC recombinant proteins, rSPARC(E268F)-His, a point substitution mutant at the Z position of EF-hand 2, failed to exhibit both Ca2+-dependent changes in alpha-helical secondary structure and anti-spreading activity. Histidine 72-75 secreted protein acidic and cysteine rich Rattus norvegicus 58-70 17046388-5 2006 Purification of different length ataxin-3 variants, including one of pathological length, is facilitated by an N-terminal hexa-histidine tag, which enables binding to a nickel-chelated agarose resin. Histidine 127-136 ataxin 3 Homo sapiens 33-41 16203134-2 2005 As a result of this study, His-modified pentapeptides with Trp were found to be more hMC4R potent than the corresponding 2-Nal analogs, novel N-caps and Gly surrogates were identified and 19 new peptides which are potent hMC4R agonists (EC(50) 1-15nM) and selective against hMC1R were discovered. Histidine 27-30 melanocortin 4 receptor Homo sapiens 85-90 16052286-3 2005 To identify the cleavage site of SaV ORF1, putative p70 (Pro-Pol) and p14-p70 (VPg-Pro-Pol) were expressed as N-terminal GST and C-terminal 6 x His-tag fusion proteins in Escherichia coli, and the expressed products were analyzed by SDS-PAGE and Western blotting. Histidine 144-147 ribonuclease P/MRP subunit p14 Homo sapiens 70-73 16080185-4 2005 Digestion of the hexahistidine tag of MBP-His(6) by Factor Xa and HT15-MBP by DAPase-1 was successful. Histidine 42-45 coagulation factor X Homo sapiens 52-61 16252006-6 2005 Thus, our findings indicate that WINAC associates with chromatin through a physical interaction between the WSTF bromodomain and acetylated his tones, which appears to be indispensable for VDR/promoter association for ligand-induced transrepression of 1alpha(OH)ase gene expression. Histidine 140-143 vitamin D receptor Homo sapiens 189-192 16106378-1 2005 Human carbonic anhydrase II (HCA II) has a histidine at position 64 (His64) that donates a proton to the zinc-bound hydroxide in catalysis of the dehydration of bicarbonate. Histidine 43-52 carbonic anhydrase 2 Homo sapiens 6-27 15943582-5 2005 Individual mutation of the ten histidine residues to asparagine in the catalytic domain of murine GPI-PLD resulted in three general phenotypes: not secreted or retained (His56 or His88), secreted with catalytic activity (His34, His81, His98 or His219) and secreted without catalytic activity (His29, His125, His133 or His158). Histidine 31-40 glycosylphosphatidylinositol specific phospholipase D1 Mus musculus 98-105 16109718-10 2005 In contrast, the interaction of AUF1 with the ATF3 mRNA is decreased in histidine-deprived cells relative to control cells. Histidine 72-81 heterogeneous nuclear ribonucleoprotein D Homo sapiens 32-36 16201751-0 2005 Structural characterization of the proximal and distal histidine environment of cytoglobin and neuroglobin. Histidine 55-64 neuroglobin Homo sapiens 95-106 16201751-1 2005 Cytoglobin (Cgb) and neuroglobin (Ngb) are the first examples of hexacoordinated globins from humans and other vertebrates in which a histidine (His) residue at the sixth position of the heme iron is an endogenous ligand in both the ferric and ferrous forms. Histidine 134-143 neuroglobin Homo sapiens 21-32 16201751-1 2005 Cytoglobin (Cgb) and neuroglobin (Ngb) are the first examples of hexacoordinated globins from humans and other vertebrates in which a histidine (His) residue at the sixth position of the heme iron is an endogenous ligand in both the ferric and ferrous forms. Histidine 134-143 neuroglobin Homo sapiens 34-37 16201751-1 2005 Cytoglobin (Cgb) and neuroglobin (Ngb) are the first examples of hexacoordinated globins from humans and other vertebrates in which a histidine (His) residue at the sixth position of the heme iron is an endogenous ligand in both the ferric and ferrous forms. Histidine 145-148 neuroglobin Homo sapiens 21-32 16201751-1 2005 Cytoglobin (Cgb) and neuroglobin (Ngb) are the first examples of hexacoordinated globins from humans and other vertebrates in which a histidine (His) residue at the sixth position of the heme iron is an endogenous ligand in both the ferric and ferrous forms. Histidine 145-148 neuroglobin Homo sapiens 34-37 16051603-6 2005 Additionally, mutational analysis identifies the histidine binding sites within a region highly conserved between HisZ and the functional HisRS. Histidine 49-58 histidyl-tRNA synthetase 2, mitochondrial Homo sapiens 138-143 16027123-11 2005 Chemical modification of the single histidine residue (His15) located in helix A of WT mGM-CSF with diethyl pyrocarbonate totally abolished binding to immobilized heparin. Histidine 36-45 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 87-94 16027123-13 2005 These results indicate a major role of histidine residues in the regulation of the binding of GM-CSF to GAGs, supporting the notion that an acidic microenvironment is required for GM-CSF-dependent regulation of target cells. Histidine 39-48 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 94-100 16027123-13 2005 These results indicate a major role of histidine residues in the regulation of the binding of GM-CSF to GAGs, supporting the notion that an acidic microenvironment is required for GM-CSF-dependent regulation of target cells. Histidine 39-48 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 180-186 15935379-5 2005 tRNase Z is a member of the beta-lactamase family of metal-dependent hydrolases, the signature sequence of which, the conserved histidine cluster (HxHxDH), is essential for activity. Histidine 128-137 Ribonuclease Z Drosophila melanogaster 0-8 15895369-1 2005 Zic genes comprise a family of transcription factors, characterized by the presence of a zinc-finger domain containing two cysteines and two histidines (C2-H2). Histidine 141-151 zinc finger protein of the cerebellum 1 Mus musculus 0-3 15767264-1 2005 In Arabidopsis thaliana, AUTHENTIC RESPONSE REGULATORS (ARRs) act as downstream components of the His-to-Asp phosphorelay (two-component) signaling pathway that is propagated primarily by the cytokinin receptor kinases, AUTHENTIC HIS-KINASES (AHK2, AHK3 and AHK4/CRE1). Histidine 98-101 histidine kinase 2 Arabidopsis thaliana 243-247 15771721-2 2005 Two other SNPs (CRH A145G and C240G) occur in the propeptide region at residue positions 45 and 77, respectively, that result in serine/asparagine and histidine/aspartic acid substitutions respectively. Histidine 151-160 corticotropin releasing hormone Bos taurus 16-19 15691328-6 2005 The deduced amino acid sequence showed full conservation of five His residues and one Met residue, which bind two Cu atoms that are essential for the activity of PHM. Histidine 65-68 peptidylglycine alpha-amidating monooxygenase Homo sapiens 162-165 15681171-9 2005 The results suggest that previously observed alterations in the activity of histidase, which were correlated to dietary protein intake, are mediated by rapid changes in the mRNA expression of this enzyme, and are not necessarily related to dietary histidine intake. Histidine 248-257 histidine ammonia-lyase Homo sapiens 76-85 15684398-5 2005 RC-68 contains the intact histidine motif, and hence it might be a functional counterpart of CPSF-73, whereas RC-74 lacks this motif, thus resembling CPSF-100. Histidine 26-35 integrator complex subunit 11 Homo sapiens 0-5 15659493-5 2005 Two were commonly observed (FcgammaRIIIA-48 and FcgammaRIIIA-158) and predicted for amino acid polymorphisms at FcgammaRIIIA-48: leucine/leucine (L/L), leucine/arginine (L/R), and leucine/histidine (L/H). Histidine 188-197 Fc gamma receptor IIIa Homo sapiens 28-40 15659493-5 2005 Two were commonly observed (FcgammaRIIIA-48 and FcgammaRIIIA-158) and predicted for amino acid polymorphisms at FcgammaRIIIA-48: leucine/leucine (L/L), leucine/arginine (L/R), and leucine/histidine (L/H). Histidine 188-197 Fc gamma receptor IIIa Homo sapiens 48-60 15659493-5 2005 Two were commonly observed (FcgammaRIIIA-48 and FcgammaRIIIA-158) and predicted for amino acid polymorphisms at FcgammaRIIIA-48: leucine/leucine (L/L), leucine/arginine (L/R), and leucine/histidine (L/H). Histidine 188-197 Fc gamma receptor IIIa Homo sapiens 48-60 15385420-4 2005 We discovered a polymorphism in exon 2 of the porcine TBG gene that results in an amino acid change of the consensus histidine to an asparagine. Histidine 117-126 serpin family A member 7 Homo sapiens 54-57 15385420-6 2005 Binding studies indicate altered binding characteristics of the allelic variants of TBG with the asparagine (White Composite) isoform having significantly greater affinity for thyroxine than the histidine (Meishan) isoform. Histidine 195-204 serpin family A member 7 Homo sapiens 84-87 15590984-7 2004 We cloned the complete CXCL10 cDNA in a mammalian expression vector with the CMV promoter, pcDNA3.1D/V5-His-TOPO, and confirmed its expression with rat CXCL10 antibody and V5 antibody. Histidine 104-107 C-X-C motif chemokine ligand 10 Homo sapiens 23-29 15501526-9 2004 The selective VPAC(1) receptor antagonist Ac His(1) [D-Phe(2), K(15), R(16), L(27)] VIP (3-7)/GRF (8-27) reduced by 60% the basal activity with an EC(50) value of 3 nM comparable to its IC(50) value for binding. Histidine 45-48 VIP peptides Cricetulus griseus 84-87 15322091-10 2004 Following mutation of a histidine (corresponding to the position 115 in human Nox2) to leucine, this interaction was abolished. Histidine 24-33 cytochrome b-245 beta chain Homo sapiens 78-82 15326175-5 2004 The pH effect was inhibited by copper ions and was reduced or lost in cells expressing mutated TDAG8 in which histidine residues were changed to phenylalanine. Histidine 110-119 G-protein coupled receptor 65 Mus musculus 95-100 15299006-2 2004 Two new globin proteins have recently been discovered in vertebrates, neuroglobin in neurons and cytoglobin in all tissues, both showing heme hexacoordination by the distal His(E7) in the absence of gaseous ligands. Histidine 173-176 neuroglobin Homo sapiens 70-81 15358370-3 2004 The highest expression level obtained with the C-terminally His-tagged MC4r corresponded to 0.25mg active receptor/litre culture volume. Histidine 60-63 melanocortin 4 receptor Homo sapiens 71-75 15358370-4 2004 Addition of a viral signal peptide at the N-terminus of the His-tagged MC4r did not improve the expression level. Histidine 60-63 melanocortin 4 receptor Homo sapiens 71-75 15226302-2 2004 The wbpA gene that encodes this enzyme was cloned into pET-28a, overexpressed as a histidine-tagged fusion protein, and purified by nickel chelation chromatography. Histidine 83-92 UDP-N-acetyl-d-glucosamine 6-dehydrogenase Pseudomonas aeruginosa PAO1 4-8 15388974-8 2004 Through transient expression assays with T87 protoplasts, it is shown that the intracellular localization profiles of the phosphorelay intermediate Arabidopsis histidine-containing phosphotransfer factor (AHPs; e.g., AHP1 and AHP4) were markedly affected in response to cytokinin, but those of type-A ARRs were not (e.g., ARR15 and ARR16). Histidine 160-169 response regulator 15 Arabidopsis thaliana 322-327 15388974-8 2004 Through transient expression assays with T87 protoplasts, it is shown that the intracellular localization profiles of the phosphorelay intermediate Arabidopsis histidine-containing phosphotransfer factor (AHPs; e.g., AHP1 and AHP4) were markedly affected in response to cytokinin, but those of type-A ARRs were not (e.g., ARR15 and ARR16). Histidine 160-169 response regulator 16 Arabidopsis thaliana 332-337 15358233-5 2004 Furthermore, His-p53 and FLAG-XPG, but not PCNA, stimulated the Tg DNA glycosylase/AP lyase activity of GST-NTH1 or NTH1. Histidine 13-16 nth like DNA glycosylase 1 Homo sapiens 108-112 15265919-5 2004 Molecular modeling of mouse mast cell protease 6 identified four His residues, H35, H106, H108, and H238, that are conserved among pH-dependent tryptases and are exposed on the molecular surface, and these four His residues were mutated to Ala. Histidine 65-68 tryptase beta 2 Mus musculus 28-48 15265919-5 2004 Molecular modeling of mouse mast cell protease 6 identified four His residues, H35, H106, H108, and H238, that are conserved among pH-dependent tryptases and are exposed on the molecular surface, and these four His residues were mutated to Ala. Histidine 211-214 tryptase beta 2 Mus musculus 28-48 15236321-5 2004 Both rat spetex-1 and the mouse homologue contained Ser-X (X = His, Arg, or Asn) repeats in the middle portion of the proteins. Histidine 63-66 spermatogenesis associated 18 Rattus norvegicus 9-17 15294184-3 2004 pDNA encoding the luciferase was complexed with histidylated polylysine (His-pLK), a polymer that requires acidic pH for pDNA endosomal release. Histidine 73-76 polo like kinase 1 Homo sapiens 77-80 15269838-1 2004 The anti-angiogenic properties of the histidine-proline-rich (H/P) domain of HPRG have recently been described (Juarez JC, et al. Histidine 38-47 histidine rich glycoprotein Homo sapiens 77-81 15161925-8 2004 Deletion of these adjacent sequences or mutation of the conserved cysteines or histidine in the zinc binding motif not only inhibits protein interaction but also eliminates DNA binding, demonstrating that DEAF-1 protein-protein interaction is required for DNA recognition. Histidine 79-88 DEAF1 transcription factor Homo sapiens 205-211 15138272-1 2004 Histidine-rich glycoprotein (HRG) is an alpha2-glycoprotein found in mammalian plasma at high concentrations (approximately 150 microg/ml) and is distinguished by its high content of histidine and proline. Histidine 183-192 histidine rich glycoprotein Homo sapiens 0-27 15138272-1 2004 Histidine-rich glycoprotein (HRG) is an alpha2-glycoprotein found in mammalian plasma at high concentrations (approximately 150 microg/ml) and is distinguished by its high content of histidine and proline. Histidine 183-192 histidine rich glycoprotein Homo sapiens 29-32 15138272-2 2004 Structurally, HRG is a modular protein consisting of an N-terminal cystatin-like domain (N1N2), a central histidine-rich region (HRR) flanked by proline-rich sequences, and a C-terminal domain. Histidine 106-115 histidine rich glycoprotein Homo sapiens 14-17 15196988-7 2004 In contrast, the catalytic efficiency of the CYP2A13 Ala(117) --> Val and His(372) --> Arg mutants was greatly increased (2.65 and 2.60 versus 0.31 for wild-type CYP2A13 protein). Histidine 77-80 cytochrome P450 family 2 subfamily A member 13 Homo sapiens 45-52 15196988-7 2004 In contrast, the catalytic efficiency of the CYP2A13 Ala(117) --> Val and His(372) --> Arg mutants was greatly increased (2.65 and 2.60 versus 0.31 for wild-type CYP2A13 protein). Histidine 77-80 cytochrome P450 family 2 subfamily A member 13 Homo sapiens 168-175 15326283-5 2004 In the wild-type insulin, binding of zinc ions by B10 His overcomes this problem, whereas in the B10 mutant this possibility is ruled out by the absence of the zinc binding site. Histidine 54-57 ectonucleotide pyrophosphatase/phosphodiesterase 3 Homo sapiens 50-53 15087452-3 2004 The deduced 371-amino-acid sequence shares 68% identity with human CtsW and includes the conserved catalytic triad cysteine, histidine, and asparagine found in all members of this family. Histidine 125-134 cathepsin W Homo sapiens 67-71 14996700-2 2004 PRCP cDNA was cloned in pMT/BIP/V5-HIS-C, transfected into Schneider insect (S2) cells, and purified from serum-free media. Histidine 35-38 prolylcarboxypeptidase Homo sapiens 0-4 15165844-1 2004 Caenorhabditis elegans PEB-1 is a novel protein containing a DNA-binding domain in its N terminus, which includes a Cys/His-rich FLYWCH motif also found in Drosophila Mod(mdg4) proteins, and a large C-terminal domain of unknown function. Histidine 120-123 FLYWCH-type domain-containing protein Caenorhabditis elegans 23-28 15165844-1 2004 Caenorhabditis elegans PEB-1 is a novel protein containing a DNA-binding domain in its N terminus, which includes a Cys/His-rich FLYWCH motif also found in Drosophila Mod(mdg4) proteins, and a large C-terminal domain of unknown function. Histidine 120-123 modifier of mdg4 Drosophila melanogaster 167-175 15138608-9 2004 JD2H domain with C2HC2HC2- and C5HC2-type Cys (His) clusters was identified as the region conserved among JMJD2A (1064 aa), JMJD2B (1096 aa), and JMJD2C (1056 aa) proteins. Histidine 47-50 lysine demethylase 4A Homo sapiens 106-112 15138608-9 2004 JD2H domain with C2HC2HC2- and C5HC2-type Cys (His) clusters was identified as the region conserved among JMJD2A (1064 aa), JMJD2B (1096 aa), and JMJD2C (1056 aa) proteins. Histidine 47-50 lysine demethylase 4C Homo sapiens 146-152 15165238-3 2004 Here, we show that mutations in two essential VirA residues, His-474 and Gly-657, can be complemented by the formation of mixed heterodimers, indicating that each subunit of a VirA dimer transphosphorylates the opposite subunit. Histidine 61-64 two-component VirA-like sensor kinase Agrobacterium tumefaciens 46-50 15165238-3 2004 Here, we show that mutations in two essential VirA residues, His-474 and Gly-657, can be complemented by the formation of mixed heterodimers, indicating that each subunit of a VirA dimer transphosphorylates the opposite subunit. Histidine 61-64 two-component VirA-like sensor kinase Agrobacterium tumefaciens 176-180 15136674-9 2004 Sequence analysis of the coding regions of MYH7 revealed an A-->T transversion at nucleotide position 25596 (M57965) resulting in a histidine-to-leucine amino acid change at residue 1904 (H1904L). Histidine 135-144 myosin heavy chain 7 Homo sapiens 43-47 15115518-4 2004 The mutation is predicted to result in an asparagine to histidine substitution (N160H) at the beginning of the alpha-helical 1A domain of keratin 9. Histidine 56-65 keratin 9 Homo sapiens 138-147 15128298-6 2004 The coding sequences were expressed in Escherichia coli as six-histidine tagged recombinant proteins and generated products with molecular masses of 86.1 kDa for HSP and 22.4 kDa for MnSOD. Histidine 63-72 heat shock protein 90 beta family member 2, pseudogene Homo sapiens 162-165 15084118-13 2004 Furthermore, when the His-DPhe-Arg-Trp sequence is used to replace the hAGRP Arg-Phe-Phe residues in the "mini"-AGRP (hAGRP87-120, C105A) template, a potent nanomolar agonist resulted at the mMC1R and MC3-5Rs. Histidine 22-25 agouti related neuropeptide Homo sapiens 71-76 15073296-4 2004 Chemical stability analysis and site-directed mutagenesis implicated the highly conserved residues His(395) and Asp(54) as the sites of phosphorylation in DevS and DevR, respectively. Histidine 99-102 two component transcriptional regulator DevR Mycobacterium tuberculosis H37Rv 164-168 15032831-10 2004 The results are discussed in terms of different binding properties of the heme iron to the protonated or unprotonated histidine ligand in the high-potential and low-potential forms of cytochrome b(559), respectively. Histidine 118-127 mitochondrially encoded cytochrome b Homo sapiens 184-196 15058570-6 2004 It was found that among the examined matrices, the TSK Chelate-5PW sorbent bound histidine-containing peptides the strongest, while Poros matrix was found to have a high degree of non-specific bindings. Histidine 81-90 tsukushi, small leucine rich proteoglycan Homo sapiens 51-54 14672930-3 2004 We systematically mutated all the histidine and cysteine residues in Sdh3p and Sdh4p to identify the residues involved in axial heme ligation. Histidine 34-43 succinate dehydrogenase membrane anchor subunit SDH4 Saccharomyces cerevisiae S288C 79-84 14762120-10 2004 The interaction was also confirmed by a "pull-down" assay in which histidine-tagged ACBP was used to pull down the GABA(A)alpha1. Histidine 67-76 acyl-CoA-binding protein Oryctolagus cuniculus 84-88 12905028-9 2004 PHT1 and PHT2 were shown to transport free histidine and certain di- and tripeptides, but it is not yet clear whether they are located on the plasma membrane or represent lysosomal transporters for the proton-dependent export of histidine and dipeptides from lysosomal protein degradation into the cytosol. Histidine 43-52 solute carrier family 15 member 3 Homo sapiens 9-13 12905028-9 2004 PHT1 and PHT2 were shown to transport free histidine and certain di- and tripeptides, but it is not yet clear whether they are located on the plasma membrane or represent lysosomal transporters for the proton-dependent export of histidine and dipeptides from lysosomal protein degradation into the cytosol. Histidine 229-238 solute carrier family 15 member 3 Homo sapiens 9-13 14583620-4 2004 Sequence analysis showed that Dub-1A encodes a 468-amino acid protein that has a molecular mass of approximately 51 kDa and that contains a putative catalytic domain (Cys, His, and Asp) conserved among DUB proteins. Histidine 172-175 ubiquitin specific peptidase 17-like B Mus musculus 30-36 14593094-5 2004 The first probe incorporated a photolabile p-benzoyl-l-phenylalanine into the position of His(1) of rat secretin ([Bpa(1),Tyr(10)]secretin-27). Histidine 90-93 secretin Rattus norvegicus 104-112 14593094-5 2004 The first probe incorporated a photolabile p-benzoyl-l-phenylalanine into the position of His(1) of rat secretin ([Bpa(1),Tyr(10)]secretin-27). Histidine 90-93 secretin Rattus norvegicus 130-138 14744774-6 2004 By using truncated versions of HRGP, we demonstrate that the isolated 150 amino acid-residue His/Pro-rich domain, which is also released by spontaneous proteolysis from purified HRGP, mediates the inhibitory effect on chemotaxis. Histidine 93-96 histidine rich glycoprotein Homo sapiens 31-35 14744774-6 2004 By using truncated versions of HRGP, we demonstrate that the isolated 150 amino acid-residue His/Pro-rich domain, which is also released by spontaneous proteolysis from purified HRGP, mediates the inhibitory effect on chemotaxis. Histidine 93-96 histidine rich glycoprotein Homo sapiens 178-182 14984209-0 2004 Activation of carbonic anhydrase II by active-site incorporation of histidine analogs. Histidine 68-77 carbonic anhydrase 2 Homo sapiens 14-35 14563830-5 2004 The typical HPGG motif of the cytochrome b5-like domain, and particularly histidine in this motif, is required for the activity of the enzyme, whatever the substrate. Histidine 74-83 cytochrome b5 type A Rattus norvegicus 30-43 14523020-1 2003 We created a molecular model of the human melanocortin 4 receptor (MC4R) and introduced a series of His residues into the receptor protein to form metal ion binding sites. Histidine 100-103 melanocortin 4 receptor Homo sapiens 42-65 15019487-3 2003 One of the main experimental strategies used for the study of myotoxic PLA2s is the traditional chemical modification of specific amino acid residues (His, Met, Lys, Tyr, Trp and others) and examination of the consequent effects upon the enzymatic, toxic and pharmacological activities. Histidine 151-154 phospholipase A2 group IIA Homo sapiens 71-76 14643929-7 2003 It is concluded that Sur2p is a membrane-bound hydroxylase that belongs to the diiron family of eight-histidine motif enzymes. Histidine 102-111 sphingosine hydroxylase Saccharomyces cerevisiae S288C 21-26 14638781-4 2003 Only one of the two conserved histidine residues required for cathepsin B exopeptidase activity is predicted to be present. Histidine 30-39 cathepsin B Ovis aries 62-73 14534363-9 2003 In contrast, an antagonist rhodamine-Ac-Cys-Glu-His-(d-Nal)-Arg-Trp-Gly-Cys-Pro-Pro-Lys-Asp-NH2 (HS014) bound to and colocalized with MC4R-GFP on the cell surface and did not stimulate receptor internalization. Histidine 48-51 melanocortin 4 receptor Homo sapiens 134-138 14965763-2 2003 Several CART peptides that contain multiple disulfide bonds were produced by overexpression in Escherichia coli bacteria as fusion products with a C-terminal histidine tag. Histidine 158-167 CART prepropeptide Rattus norvegicus 8-12 14719827-2 2003 A gene encoding for chicken ovalbumin (Gad dI) was isolated from chicken oviduct by PCR amplification and was cloned under the control of T5 promoter fused with a six-histidine tag at the N-terminal end. Histidine 167-176 ovalbumin (SERPINB14) Gallus gallus 28-37 12959987-0 2003 Regulation of glucagon-like peptide-1 receptor and calcium-sensing receptor signaling by L-histidine. Histidine 89-100 glucagon-like peptide 1 receptor Rattus norvegicus 14-46 12959987-0 2003 Regulation of glucagon-like peptide-1 receptor and calcium-sensing receptor signaling by L-histidine. Histidine 89-100 calcium-sensing receptor Rattus norvegicus 51-75 12959987-4 2003 L-Histidine (L-His) increases the sensitivity of the CaSR to extracellular Ca2+ and potentiates glucose-dependent insulin secretion from INS-1 cells. Histidine 0-11 calcium-sensing receptor Rattus norvegicus 53-57 12959987-4 2003 L-Histidine (L-His) increases the sensitivity of the CaSR to extracellular Ca2+ and potentiates glucose-dependent insulin secretion from INS-1 cells. Histidine 0-5 calcium-sensing receptor Rattus norvegicus 53-57 12869545-2 2003 We generated mice with a point mutation in the thyroid hormone receptor alpha (TRalpha) gene producing a dominant-negative TRalpha mutant receptor with a proline to histidine substitution (P398H). Histidine 165-174 guanine nucleotide binding protein, alpha transducing 1 Mus musculus 79-86 14555798-3 2003 Because of the competition of Pr(III) for ligands with Ca(II), the percentages of free Ca2+, [Ca(Lac)], and [Ca(His)(Thr)H3] increase gradually and the percentages of CaHPO4(aq) and [Ca(Cit)(His)H2] decrease gradually with the increase in the total concentration of Pr(III). Histidine 112-115 carbonic anhydrase 2 Homo sapiens 55-61 14555798-3 2003 Because of the competition of Pr(III) for ligands with Ca(II), the percentages of free Ca2+, [Ca(Lac)], and [Ca(His)(Thr)H3] increase gradually and the percentages of CaHPO4(aq) and [Ca(Cit)(His)H2] decrease gradually with the increase in the total concentration of Pr(III). Histidine 191-194 carbonic anhydrase 2 Homo sapiens 55-61 14578150-7 2003 For XRCC1 codon 280 genotypes of Arg/His and His/His compared with the Arg/Arg genotype, the OR was 0.64 (95% CI, 0.43-0.96). Histidine 37-40 X-ray repair cross complementing 1 Homo sapiens 4-9 14519125-6 2003 Affinity purification of histidine-tagged eIF3k from transiently transfected COS cells copurifies other eIF3 subunits. Histidine 25-34 eukaryotic translation initiation factor 3 subunit A Homo sapiens 42-46 12750065-7 2003 Hi+ mobility is therefore low in cardiac cells, a feature that may predispose them to the generation of pHi gradients in response to sarcolemmal acid/base transport or local cytoplasmic acid production. Histidine 0-3 glucose-6-phosphate isomerase Oryctolagus cuniculus 104-107 14506148-7 2003 Four cases (25%) of SRCCC demonstrated the same A:T transversion at the third base position of K-ras codon 61 (CAA to CAT; Gln to His). Histidine 130-133 KRAS proto-oncogene, GTPase Homo sapiens 95-100 12796496-4 2003 Wild type CDH is only the second example of a b-type heme with Met-His ligation, and it is the first example of a Met-His ligation of heme b where the ligands are arranged in a nearly perpendicular orientation. Histidine 67-70 choline dehydrogenase Homo sapiens 10-13 12794073-7 2003 A molecular model of DmPBGS suggests that the inhibitory zinc is located at a subunit interface using Cys-219 and His-10 as ligands. Histidine 114-117 Porphobilinogen synthase Drosophila melanogaster 21-27 12941880-6 2003 These results support the view that ARR15 acts as a repressor that mediates a negative feedback loop in the cytokinin and AHK4-mediated His-->Asp phosphorelay. Histidine 136-139 response regulator 15 Arabidopsis thaliana 36-41 12736264-7 2003 Consistent with this result, we showed that mutation of the final histidine had only a modest effect on DNA binding in the context of the full three-finger DNA-binding domain of basic Kruppel-like factor. Histidine 66-75 Kruppel like factor 3 Homo sapiens 178-203 12716883-3 2003 Following intracellular overexpression in fusion with a histidine affinity tag in Escherichia coli, purification under denaturing conditions, and removal of denaturant through dialysis, retro-HSP12.6 was found to fold to a soluble state. Histidine 56-65 SHSP domain-containing protein Caenorhabditis elegans 192-199 12837291-6 2003 However, the responses of the two templates differ mechanistically in that the CREB-binding protein p300 potentiates activation from the transient template in a manner dependent on its Cys/His-rich region 3, but does not appear to affect the repression of the replicating chromatin template. Histidine 189-192 cAMP responsive element binding protein 1 Homo sapiens 79-83 12810953-1 2003 PKC-interacting protein (PKCI), also designated histidine triad nucleotide-binding protein 1, belongs to the histidine triad (HIT) family of proteins. Histidine 48-57 protein kinase C, iota Mus musculus 0-23 12810953-1 2003 PKC-interacting protein (PKCI), also designated histidine triad nucleotide-binding protein 1, belongs to the histidine triad (HIT) family of proteins. Histidine 48-57 protein kinase C, iota Mus musculus 25-29 12771253-12 2003 This resulted in heterozygosity for normal tyrosine and variant histidine (ATTR Tyr69His) in affected family members. Histidine 64-73 transthyretin Homo sapiens 75-79 12595535-10 2003 We show that a completely inactive tyrosinase point mutant lacking a critical histidine residue involved in copper binding is nevertheless able to exit from the ER and undergo further processing. Histidine 78-87 tyrosinase Homo sapiens 35-45 12817480-6 2003 In the present study we have overexpressed the human meprin alpha subunit and a His-tagged soluble tail-switch-mutant of meprin beta in Baculovirus-infected insect cells. Histidine 80-83 meprin A subunit beta Homo sapiens 121-132 12833571-9 2003 It was also revealed that the TS1 binding to cytokeratin 8 and alphaTS1 respectively are partly overlapping; a histidine identified in TS1 is probably involved only in the interaction with alphaTS1. Histidine 111-120 keratin 8 Homo sapiens 45-58 12551905-0 2003 The role of the invariant His-1069 in folding and function of the Wilson"s disease protein, the human copper-transporting ATPase ATP7B. Histidine 26-29 ATPase copper transporting beta Homo sapiens 129-134 12540839-0 2003 YC-1 facilitates release of the proximal His residue in the NO and CO complexes of soluble guanylate cyclase. Histidine 41-44 RNA binding motif single stranded interacting protein 1 Homo sapiens 0-4 12540839-6 2003 These results revealed that YC-1 facilitated cleavage of the proximal His-iron bond and caused geometrical distortion of the five-coordinate NO-heme. Histidine 70-73 RNA binding motif single stranded interacting protein 1 Homo sapiens 28-32 12540839-9 2003 These results indicate that YC-1 stimulates enzyme activity by weakening or cleaving the proximal His-iron bond in the CO complex as well as the NO complex. Histidine 98-101 RNA binding motif single stranded interacting protein 1 Homo sapiens 28-32 12501240-9 2003 Individual mutation of His-64, His-228, or His-352 in GIRK4 abolished or greatly diminished the inhibition in homomeric GIRK4. Histidine 23-26 potassium inwardly rectifying channel subfamily J member 5 Homo sapiens 54-59 12581208-10 2003 EPR of the nitrosyl heme complex has established the nitrogenous proximal ligand, presumably histidine 17 and the obtained EPR parameters are discriminated from those of the rat heme oxygenase-1 complex. Histidine 93-102 heme oxygenase 1 Rattus norvegicus 178-194 12534281-9 2003 The catalytic triad of DP8 was shown to be Ser(739)-Asp (817)-His(849). Histidine 62-65 dipeptidyl peptidase 8 Homo sapiens 23-26 12361957-9 2002 Such activation was eliminated when a histidine residue in the M1-H5 linker was mutated to a non-titratable glutamine, i.e. H116Q in GIRK1 and H120Q in GIRK4. Histidine 38-47 potassium inwardly rectifying channel subfamily J member 3 S homeolog Xenopus laevis 133-138 12193598-6 2002 The Erf2p/Erf4p complex is required for Ras PAT activity, and mutations within conserved residues (Cys(189), His(201), and Cys(203)) of the Erf2p DHHC-CRD domain abolish Ras PAT activity. Histidine 109-112 Shr5p Saccharomyces cerevisiae S288C 10-15 12163504-3 2002 Two-dimensional crystals of Pgp in a lipid bilayer were generated by reconstituting pure, detergent-solubilized protein containing a C-terminal six-histidine tag using the lipid monolayer technique. Histidine 148-157 phosphoglycolate phosphatase Mus musculus 28-31 12217858-1 2002 We purified His-tagged ROMK1 and carried out in vitro phosphorylation assays with (32)P-radiolabeled ATP to determine whether ROMK1 protein is a substrate for PTK. Histidine 12-15 potassium inwardly-rectifying channel, subfamily J, member 1 Rattus norvegicus 23-28 12356468-3 2002 PCR methodologies were used to subclone the gene encoding the functional Delta(3)-Delta(2)-enoyl-CoA isomerase from pAG847 with primers that were designed to add six continuous histidine codon to the 5(") primer. Histidine 177-186 enoyl-CoA delta isomerase 1 Rattus norvegicus 73-110 12204228-4 2002 Recombinant six-histidine tagged schistosome thioredoxin had insulin reduction activity and supported the enzymatic function of thioredoxin reductase and thioredoxin peroxidase. Histidine 16-25 thioredoxin 1 Mus musculus 45-56 12204228-4 2002 Recombinant six-histidine tagged schistosome thioredoxin had insulin reduction activity and supported the enzymatic function of thioredoxin reductase and thioredoxin peroxidase. Histidine 16-25 thioredoxin 1 Mus musculus 128-139 12204228-4 2002 Recombinant six-histidine tagged schistosome thioredoxin had insulin reduction activity and supported the enzymatic function of thioredoxin reductase and thioredoxin peroxidase. Histidine 16-25 thioredoxin 1 Mus musculus 128-139 12213855-8 2002 However, a missense point mutation was detected in the SDHB gene: c.725G-->A in exon 7, which alters a conserved arginine at amino acid position 242 to a histidine (R242H). Histidine 157-166 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 55-59 12077146-3 2002 We introduced histidines into sites located in the second and third putative extracellular loops of CXCR1, creating single, double, and triple mutant receptors: R199H, R203H, D265H, R199H/R203H, R199H/D265H, R203H/D265H, R203H/H207Q, and R199H/R203H/D265H. Histidine 14-24 C-X-C motif chemokine receptor 1 Homo sapiens 100-105 12077146-6 2002 On the other hand, cells expressing all single, double, or triple histidine-substituted CXCR1 demonstrated high affinity binding to interleukin 8 in the presence and absence of metal ions. Histidine 66-75 C-X-C motif chemokine receptor 1 Homo sapiens 88-93 12146983-3 2002 Here, we investigate topological effects on loop formation probabilities in denatured iso-1-cytochrome c by comparing histidine-heme binding affinities for histidines on the N- versus the C-terminal side of the heme. Histidine 118-127 eukaryotic translation initiation factor 1 Homo sapiens 86-91 12146983-3 2002 Here, we investigate topological effects on loop formation probabilities in denatured iso-1-cytochrome c by comparing histidine-heme binding affinities for histidines on the N- versus the C-terminal side of the heme. Histidine 156-166 eukaryotic translation initiation factor 1 Homo sapiens 86-91 12205739-4 2002 alphaMSH analogues [(6)His]alphaMSH-ND and [(6)Asn]alphaMSH-ND were synthesized and the radio-ligand receptor binding- and cyclic AMP generating activity were analyzed in China Hamster Ovary cell line over- expressing melanocortin receptors. Histidine 23-26 proopiomelanocortin Rattus norvegicus 0-8 12205739-5 2002 The EC(50) of [(6)His]alphaMSH-ND measured from melanocortin-1, 3, 4 and 5 receptors were 0.008 +/- 0.0045, 1.523 +/- 0.707, 0.780 +/- 0.405, and 250.320 +/- 42.234 nM, respectively, and the EC(50) of [(6)Asn]alphaMSH-ND were 16.8 +/- 6.94, 271.8 +/- 21.95, 8.0 +/- 1.21, and 1132.5 +/- 635.46 nM, respectively. Histidine 18-21 proopiomelanocortin Rattus norvegicus 22-30 12139236-2 2002 There are at least two known alleles of MIC-1 that are due to a G-->C point substitution at position 6 of the mature protein, which alters a histidine to an aspartic acid (MIC-1 H and MIC-1 D). Histidine 144-153 growth differentiation factor 15 Homo sapiens 40-45 12139236-2 2002 There are at least two known alleles of MIC-1 that are due to a G-->C point substitution at position 6 of the mature protein, which alters a histidine to an aspartic acid (MIC-1 H and MIC-1 D). Histidine 144-153 growth differentiation factor 15 Homo sapiens 175-180 12139236-2 2002 There are at least two known alleles of MIC-1 that are due to a G-->C point substitution at position 6 of the mature protein, which alters a histidine to an aspartic acid (MIC-1 H and MIC-1 D). Histidine 144-153 growth differentiation factor 15 Homo sapiens 175-180 12082127-4 2002 It has been proposed that this species specificity of the hGHR is largely caused by the Leu --> Arg change at position 43 after a prior His --> Asp change at position 171 of the GH. Histidine 139-142 growth hormone receptor Homo sapiens 58-62 12055292-2 2002 The predicted protein of 512 aa shared 53% sequence identity with the two fatty acid Delta9-desaturases, ole1p and ole2p, already described in this organism and contained three histidine boxes, four putative transmembrane domains and a C-terminal cytochrome b(5) fusion that are typical of most fungal membrane-bound fatty acid desaturases. Histidine 177-186 stearoyl-CoA 9-desaturase Saccharomyces cerevisiae S288C 105-110 12028580-0 2002 Molecular anatomy of tyrosinase and its related proteins: beyond the histidine-bound metal catalytic center. Histidine 69-78 tyrosinase Homo sapiens 21-31 12071694-1 2002 BfpA, the structural repeating protein subunit A of the bundle-forming pilus and EspB, a type-III-secreted pore-forming protein of enteropathogenic Escherichia coli (EPEC), both virulence factors central for EPEC pathogenesis, were overexpressed in E. coli DH5alpha and M15 laboratory strains, respectively, using the pQE-30 cloning expression system, as chimeric fusions to a NH(2)-terminal histidine hexapeptide (His(6)-tag) sequence. Histidine 392-401 Major pilin structural unit bundlin Escherichia coli 0-4 11893736-0 2002 Importance of the histidine ligand to coenzyme B12 in the reaction catalyzed by methylmalonyl-CoA mutase. Histidine 18-27 methylmalonyl-CoA mutase Homo sapiens 80-104 11896050-5 2002 rMCP-4 was expressed with an N-terminal His tag followed by an enterokinase site substituting for the native activation peptide. Histidine 40-43 mast cell protease 4 Rattus norvegicus 0-6 11884405-3 2002 In this study, we probed the functional properties of two histidines (His-120 and His-122) and a tyrosine (Tyr-168) postulated to be important in the mechanism of AANAT based on prior x-ray structural and biochemical studies. Histidine 58-68 aralkylamine N-acetyltransferase Homo sapiens 163-168 11884405-3 2002 In this study, we probed the functional properties of two histidines (His-120 and His-122) and a tyrosine (Tyr-168) postulated to be important in the mechanism of AANAT based on prior x-ray structural and biochemical studies. Histidine 70-73 aralkylamine N-acetyltransferase Homo sapiens 163-168 11884405-4 2002 Using a combination of steady-state kinetic measurements of microviscosity effects and pH dependence on the H122Q, H120Q, and H120Q/H122Q AANAT mutants, we show that His-122 (with an apparent pK(a) of 7.3) contributes approximately 6-fold to the acetyltransferase chemical step as either a remote catalytic base or hydrogen bond donor. Histidine 166-169 aralkylamine N-acetyltransferase Homo sapiens 138-143 11867614-3 2002 Nmp4 isoforms contain from 5 to 8 Cys(2)His(2) zinc fingers, an SH3-binding domain that overlaps with a putative AT-hook and a polyglutamine-alanine repeat (poly(QA)). Histidine 40-43 zinc finger protein 384 Homo sapiens 0-4 11867614-4 2002 To determine the mechanistic significance of Cys(2)His(2) zinc finger association with this unusual consensus DNA binding element, we identified the Nmp4 DNA-binding and transcriptional activation domains. Histidine 51-54 zinc finger protein 384 Homo sapiens 149-153 11939775-8 2002 Like Co(2+), Fe(2+) bound to yeast ferrochelatase was coordinated by approximately six oxygen or nitrogen ligands, again with evidence of two histidine ligands. Histidine 142-151 ferrochelatase Mus musculus 35-49 11799105-3 2002 The three-dimensional structure of NAT from Salmonella typhimurium has been resolved and shown to have three distinct domains and an active site catalytic triad composed of "Cys(69)-His(107)-Asp(122)," which is typical of hydrolytic enzymes such as the cysteine proteases. Histidine 182-185 bromodomain containing 2 Homo sapiens 35-38 11916859-6 2002 The histidine-modifying reagent, diethyl pyrocarbonate, reversibly blocks cx50 hemichannel currents but not cx46 hemichannel currents. Histidine 4-13 gap junction protein alpha 8 Homo sapiens 74-78 11916859-7 2002 Because cx46 and cx50 have very similar amino acid sequences, one might expect that replacing the two histidines unique to the third transmembrane region of cx50 with the corresponding cx46 residues would produce mutants more closely resembling cx46. Histidine 102-112 gap junction protein alpha 8 Homo sapiens 17-21 11916859-7 2002 Because cx46 and cx50 have very similar amino acid sequences, one might expect that replacing the two histidines unique to the third transmembrane region of cx50 with the corresponding cx46 residues would produce mutants more closely resembling cx46. Histidine 102-112 gap junction protein alpha 8 Homo sapiens 157-161 11948105-10 2002 The most active immunotoxin contained amino acid residues Thr-His-Trp (THW) in place of Ser-Ser-Tyr (SSY) at positions 100, 100A, and 100B of the Fv and had an affinity improved from 85 nM to 6 nM. Histidine 62-65 p53 apoptosis effector related to PMP22 Homo sapiens 71-74 11835157-6 2002 We used the Hoffman degradation reaction to convert the amide groups of acrylamide to amine groups, and then we used ethylene glycol diglycidyl ether to attach biomolecules of interest inside the holes: secreted protein acidic and rich in cysteine (SPARC) peptide Lys-Gly-His-Lys (KGHK; angiogenic), thrombospondin-2 (TSP; antiangiogenic), or albumin (rat; neutral). Histidine 272-275 secreted protein acidic and cysteine rich Rattus norvegicus 203-247 11922758-2 2002 The hH4 cDNA was subcloned into the pQE30 expression vector, in frame with a sequence encoding an N-terminal stretch of six histidine residues. Histidine 124-133 prokineticin 2 Homo sapiens 4-7 11741991-4 2002 Its five tandem Cys(2)-His(2) zinc finger motifs exhibit the highest homology to those of members of the Gli and Zic subfamilies of Kruppel-like proteins. Histidine 23-26 zinc finger protein of the cerebellum 1 Mus musculus 113-116 11781309-8 2002 Furthermore, mutations in this lysine and in a histidine residue that is also predicted to be important for pyridoxal 5"-phosphate binding to Lcb2p also dominantly inactivate SPT similar to the hereditary sensory neuropathy type 1-like mutations in Lcb1p. Histidine 47-56 serine C-palmitoyltransferase LCB2 Saccharomyces cerevisiae S288C 142-147 11895450-1 2002 Histidine ammonia-lyase (EC 4.3.1.3) catalyzes the nonoxidative elimination of the alpha-amino group of histidine using a 4-methylidene-imidazole-5-one (MIO), which is formed autocatalytically from the internal peptide segment 142Ala-Ser-Gly. Histidine 104-113 histidine ammonia-lyase Homo sapiens 0-23 11741986-7 2002 The sequence of the protease domain carried the essential triad His, Asp, and Ser and showed some similarity to that of TMPRSS2, hepsin, HAT, MT-SP1, TMPRSS3, and corin, sharing 45.5, 41.9, 41.3, 40.3, 39.1, and 38.5% identity, respectively. Histidine 64-67 hepsin Homo sapiens 129-135 22896886-1 2002 Wheat germ lipase (WGL) was inactivated by chemical modification of histidine, serine and carboxyl groups of Asp/Glu residues with diethyl pyrocarbonate (DEPC), phenyl methyl sulfonyl fluoride (PMSF) and 1-ethyl-3-(3-dimethylaminopropyl) carbodi-imide (EDC), respectively. Histidine 68-77 probable feruloyl esterase A Triticum aestivum 11-17 11841570-5 2002 Their rank order of potency in P2X4 and P2X7 receptors was carnosine = PA = His > BPh > Glycine (Gly) and carnosine = BPh = His > PA > Gly, respectively. Histidine 76-79 purinergic receptor P2X 4 Rattus norvegicus 31-35 11841570-6 2002 The potency to prevent the zinc-induced potentiation in the P2X4 receptor was BPh > PA > His; carnosine, Gly and beta-alanine were inactive. Histidine 95-98 purinergic receptor P2X 4 Rattus norvegicus 60-64 11799199-8 2002 The enzyme activity of the VP1 unique region showed typical Ca(2+) dependency and could be inhibited by manoalide and 4-bromophenacylbromide, which bind covalently to lysine and histidine residues, respectively, as part of the active center of the enzyme. Histidine 178-187 capsid protein 1 Human parvovirus B19 27-30 11850543-5 2002 All MRT samples had missense mutations in the human KRT 8 gene, i.e., Arg89 --> Cys (5/7); Arg --> Cys251 (3/7); Glu267 --> Lys (6/7); Ser290 --> Ile, Met; (7/7) and Arg301 --> His(4/7), none of which was detected in any control samples. Histidine 192-195 keratin 8 Homo sapiens 52-57 11785967-0 2002 Modification of histidine (B10) is the causative agent for a superactive form of insulin. Histidine 16-25 ectonucleotide pyrophosphatase/phosphodiesterase 3 Homo sapiens 27-30 11785967-3 2002 It was found that the insulin was bound to the resin through histidine B10, His (B10), and its ammonium bicarbonate-mediated release resulted in an insulin analog in which His (B10) was modified on the imidazole ring. Histidine 61-70 ectonucleotide pyrophosphatase/phosphodiesterase 3 Homo sapiens 71-74 11785967-3 2002 It was found that the insulin was bound to the resin through histidine B10, His (B10), and its ammonium bicarbonate-mediated release resulted in an insulin analog in which His (B10) was modified on the imidazole ring. Histidine 76-79 ectonucleotide pyrophosphatase/phosphodiesterase 3 Homo sapiens 81-84 11785967-3 2002 It was found that the insulin was bound to the resin through histidine B10, His (B10), and its ammonium bicarbonate-mediated release resulted in an insulin analog in which His (B10) was modified on the imidazole ring. Histidine 76-79 ectonucleotide pyrophosphatase/phosphodiesterase 3 Homo sapiens 81-84 11785967-6 2002 Since Asp (B10) insulin is also superactive, the observed superactivity may thus stem from either modification of the histidine or its conversion to aspartic acid. Histidine 118-127 ectonucleotide pyrophosphatase/phosphodiesterase 3 Homo sapiens 11-14 11784781-6 2002 Cu toxicity induced by human APP, Xenopus APP, and APLP2 CuBDs is dependent on conservation of histidine residues at positions corresponding to 147 and 151 of human APP. Histidine 95-104 amyloid beta (A4) precursor-like protein 2 L homeolog Xenopus laevis 51-56 11782367-7 2002 Transient expression of dominant-negative p53 ((175)Arg-->His) counteracted the detrimental effects of BPDE on BRCA-1 promoter activity and protein levels. Histidine 61-64 BRCA1 DNA repair associated Homo sapiens 114-120 11571292-6 2001 The histidine-alanine-valine region of the FGFR has previously been implicated in the N-cadherin response, and a candidate interaction site has been identified in extracellular domain 4 of N-cadherin. Histidine 4-13 cadherin 2 Homo sapiens 86-96 11571292-6 2001 The histidine-alanine-valine region of the FGFR has previously been implicated in the N-cadherin response, and a candidate interaction site has been identified in extracellular domain 4 of N-cadherin. Histidine 4-13 cadherin 2 Homo sapiens 189-199 11489879-2 2001 In an effort to identify amino acid residues near the phylloquinone binding sites, all tryptophans and histidines that are conserved between PsaA and PsaB in the region of the 10th and 11th transmembrane alpha-helices were mutated in Chlamydomonas reinhardtii. Histidine 103-113 photosystem I P700 chlorophyll a apoprotein A2 Chlamydomonas reinhardtii 150-154 11570891-2 2001 Diethyl pyrocarbonate inhibits the reaction of cytochrome b(561) with ascorbate by modifying a histidine residue in the ascorbate-binding site. Histidine 95-104 mitochondrially encoded cytochrome b Homo sapiens 47-59 11570891-10 2001 (1) The ascorbate monoanion binds to an unprotonated site (histidine) on cytochrome b(561). Histidine 59-68 mitochondrially encoded cytochrome b Homo sapiens 73-85 11579202-0 2001 Cloning and characterization of gonadotropin-inducible ovarian transcription factors (GIOT1 and -2) that are novel members of the (Cys)(2)-(His)(2)-type zinc finger protein family. Histidine 140-143 gonadotropin inducible ovarian transcription factor 1 Rattus norvegicus 86-98 11415439-2 2001 They contain two and three thioredoxin boxes (Cys-Gly-His-Cys) respectively and, like PDI, may be involved in the folding of nascent proteins. Histidine 54-57 prolyl 4-hydroxylase subunit beta Rattus norvegicus 86-89 11371465-1 2001 The gene encoding for bacterial cytochrome c-551 from Pseudomonas stutzeri substrain ZoBell has been mutated to convert the invariant sixth ligand methionine residue into histidine, creating the site-specific mutant M61H. Histidine 171-180 cytochrome c3 family protein Pseudomonas stutzeri 32-44 11279129-6 2001 Exchange of His-90 of AtHAL3a for Asn led to complete inactivation of the enzyme. Histidine 12-15 HAL3-like protein A Arabidopsis thaliana 22-29 11336800-9 2001 Rather, the data suggest that the enhancement in cAMP potency arises from the formation of a ternary complex between [His(10)]-PTH(1-14), a zinc atom, and the extracellular loop/transmembrane domain region of the PTH-1 receptor. Histidine 118-121 parathyroid hormone 1 receptor Rattus norvegicus 213-227 11250654-4 2001 Our data revealed that full-length IGFBP-4 peptides lacking the residues Leu(72)-Ser(91) or Leu(72)-His(74) or Gly(75)-Ser(91) failed to bind to IGF-I or IGF-II, whereas deletion of the residue Leu(72) or residues Met(80)-Ser(91) led to a 2- to 3-fold reduction in IGF-I and IGF-II binding activity. Histidine 100-103 insulin like growth factor binding protein 4 Homo sapiens 35-42 11327835-1 2001 Histidine 64 in human carbonic anhydrase II (HCA II) functions in the catalytic pathway of CO(2) hydration as a shuttle to transfer protons between the zinc-bound water and bulk water. Histidine 0-9 carbonic anhydrase 2 Homo sapiens 22-43 11067847-11 2001 The data collectively indicate that His-12 and Asp-258, but not Cys-183 or Cys-281, are required for the PTP activity of PAcP. Histidine 36-39 protein tyrosine phosphatase non-receptor type 22 Homo sapiens 105-108 11067847-11 2001 The data collectively indicate that His-12 and Asp-258, but not Cys-183 or Cys-281, are required for the PTP activity of PAcP. Histidine 36-39 acid phosphatase 3 Homo sapiens 121-125 11319928-5 2001 The large putative Rep protein encoded by pME2001 was overexpressed in Escherichia coli as an N-terminal His-tagged version using pET28a and a compatible helper plasmid that coexpresses minor tRNAs, argU and ileX to compensate for codon usage difference. Histidine 105-108 replication protein Escherichia coli 19-22 11162372-6 2000 Upon introduction of parasite CpMBF1 into S. cerevisiae, 3-amino triazole resistance of the MBF1-deficient strain was restored to wild-type levels, and Northern blot analysis revealed that CpMBF1 was able to activate HIS3 transcription in response to histidine starvation. Histidine 251-260 imidazoleglycerol-phosphate dehydratase HIS3 Saccharomyces cerevisiae S288C 217-221 11120754-3 2000 Here, we demonstrate that PV IgGs eluted from rDsg1-Ig-His and rDsg3-Ig-His show similar antigenic profiles, including the 38-, 43-, 115-, and 190-kDa keratinocyte proteins and a non-Dsg 3 130-kDa polypeptide present in keratinocytes from Dsg 3 knockout mouse. Histidine 55-58 desmoglein 1 Rattus norvegicus 46-51 11120754-3 2000 Here, we demonstrate that PV IgGs eluted from rDsg1-Ig-His and rDsg3-Ig-His show similar antigenic profiles, including the 38-, 43-, 115-, and 190-kDa keratinocyte proteins and a non-Dsg 3 130-kDa polypeptide present in keratinocytes from Dsg 3 knockout mouse. Histidine 55-58 desmoglein 1 Homo sapiens 47-50 11120754-3 2000 Here, we demonstrate that PV IgGs eluted from rDsg1-Ig-His and rDsg3-Ig-His show similar antigenic profiles, including the 38-, 43-, 115-, and 190-kDa keratinocyte proteins and a non-Dsg 3 130-kDa polypeptide present in keratinocytes from Dsg 3 knockout mouse. Histidine 72-75 desmoglein 1 Homo sapiens 64-67 10992296-7 2000 The hBUB1 gene of one adenocarcinoma tumor contained a somatic missense mutation, a cytosine-to-guanine substitution in codon 51 of exon 5 that resulted in a histidine-to-aspartic acid amino acid substitution. Histidine 158-167 BUB1 mitotic checkpoint serine/threonine kinase Homo sapiens 4-9 11186130-3 2000 Two variant UGT2B7 cDNAs encoding enzymes with either His or Tyr at residue 268 have been isolated. Histidine 54-57 UDP glucuronosyltransferase family 2 member B7 Homo sapiens 12-18 10998050-1 2000 A single mutation, involving the replacement of an arginine residue with histidine to reconstruct a zinc-binding site, suffices to change a catalytically inactive murine carbonic anhydrase-related protein (CARP) to an active carbonic anhydrase with a CO2-hydration turnover number of 1.2 x 104 s-1. Histidine 73-82 carbonic anhydrase 8 Mus musculus 170-204 11054275-4 2000 Bacterially expressed ChIL-18 in which the N-terminal 29 amino acids of the putative precursor molecule were replaced by a histidine tag induced the synthesis of interferon-gamma (IFN-gamma) in cultured primary chicken spleen cells, indicating that the recombinant protein is biologically active. Histidine 123-132 interferon gamma Gallus gallus 162-178 11054275-4 2000 Bacterially expressed ChIL-18 in which the N-terminal 29 amino acids of the putative precursor molecule were replaced by a histidine tag induced the synthesis of interferon-gamma (IFN-gamma) in cultured primary chicken spleen cells, indicating that the recombinant protein is biologically active. Histidine 123-132 interferon gamma Gallus gallus 180-189 10986467-6 2000 The proximal and distal histidine sidechains coordinate directly to the heme iron, forming a hemichrome with spectral properties similar to those of cytochrome b(5). Histidine 24-33 mitochondrially encoded cytochrome b Homo sapiens 149-161 10945855-4 2000 Using site-directed mutagenesis, we investigated whether mutating residues Trp-318 and His-319 to their corresponding residues in kappa- and delta-opioid receptors provides the molecular basis for mu/delta selectivity and mu/kappa selectivity. Histidine 87-90 opioid receptor kappa 1 Homo sapiens 130-163 10913314-1 2000 The gene nirM, coding for cytochrome c-551 in Pseudomonas stutzeri substrain ZoBell, was engineered to mutate Met61, the sixth ligand to the heme c, into His61, thereby converting the typical Met-His coordination of a c-type cytochrome into His-His, typical of b-type cytochromes. Histidine 154-157 cytochrome c3 family protein Pseudomonas stutzeri 26-38 10913314-1 2000 The gene nirM, coding for cytochrome c-551 in Pseudomonas stutzeri substrain ZoBell, was engineered to mutate Met61, the sixth ligand to the heme c, into His61, thereby converting the typical Met-His coordination of a c-type cytochrome into His-His, typical of b-type cytochromes. Histidine 196-199 cytochrome c3 family protein Pseudomonas stutzeri 26-38 10913314-1 2000 The gene nirM, coding for cytochrome c-551 in Pseudomonas stutzeri substrain ZoBell, was engineered to mutate Met61, the sixth ligand to the heme c, into His61, thereby converting the typical Met-His coordination of a c-type cytochrome into His-His, typical of b-type cytochromes. Histidine 196-199 cytochrome c3 family protein Pseudomonas stutzeri 26-38 10862049-5 2000 Two mutations in the CDKN2A (p16) gene were detected, including a novel base change AAC-->ATC (Asn to Ile) at codon 71, that also changes the codon 85 of the alternative reading frame gene p14(ARF) from CAA to CAT (Gln to His). Histidine 225-228 glycine-N-acyltransferase Homo sapiens 84-87 10894741-4 2000 The fre gene was cloned, and the overexpressed protein, with a histidine tag at its N terminus, was purified to homogeneity by nickel affinity chromatography. Histidine 63-72 NAD(P)H-flavin reductase Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 4-7 10908293-2 2000 In the beta(2)-adrenergic receptor the agonist binding site has previously been structurally and functionally exchanged with an activating metal-ion site located between AspIII:08-or a His residue introduced at this position in transmembrane domain (TM)-III-and a Cys residue substituted for AsnVII:06 in TM-VII. Histidine 185-188 adrenoceptor beta 2 Homo sapiens 7-34 10873770-6 2000 SPI-3 protein lacking the N-terminal signal peptide was purified by means of an N-terminal His(10)-tag and gave complete inhibition in vitro of plasmin, uPA, and tPA and partial inhibition of factor Xa. Histidine 91-94 serpin family B member 6 Homo sapiens 0-5 10872755-0 2000 Metal-catalyzed oxidation of brain-derived neurotrophic factor (BDNF): selectivity and conformational consequences of histidine modification. Histidine 118-127 brain derived neurotrophic factor Homo sapiens 29-62 10872755-0 2000 Metal-catalyzed oxidation of brain-derived neurotrophic factor (BDNF): selectivity and conformational consequences of histidine modification. Histidine 118-127 brain derived neurotrophic factor Homo sapiens 64-68 10704983-0 2000 Enthalpy and enzyme activity of modified histidine residues of adenosine deaminase and diethyl pyrocarbonate complexes. Histidine 41-50 adenosine deaminase Homo sapiens 63-82 10704983-1 2000 Kinetic and thermodynamic studies have been made on the effect of diethyl pyrocarbonate as a histidine modifier on the active site of adenosine deaminase in 50 mM sodium phosphate buffer pH 6.8, at 27 degrees C using UV spectrophotometry and isothermal titration calorimetry (ITC). Histidine 93-102 adenosine deaminase Homo sapiens 134-153 10704983-3 2000 The number of modified histidine residues complexed to active site of adenosine deaminase are equivalent to 4. Histidine 23-32 adenosine deaminase Homo sapiens 70-89 10704201-3 2000 The recombinant variants (i.e., H207N and E287Q) are enzymes in which the conserved amino acids histidine-207 and glutamate-287 of murine ferrochelatase were substituted with asparagine and glutamine, respectively. Histidine 96-105 ferrochelatase Mus musculus 138-152 10699485-1 2000 Glucagon-like peptide-1(7-36)amide (tGLP-1) is inactivated by dipeptidyl peptidase (DPP) IV by removal of the NH(2)-terminal dipeptide His(7)-Ala(8). Histidine 135-138 glucagon Rattus norvegicus 0-23 10719389-2 2000 A pancreatic hydrolysate of casein (trypticase peptone, 0.1 mg/ml) and some amino acids (cysteine, tryptophan and methionine, 50 microM each) also inhibited the TPO iodide oxidation reaction completely, whereas casamino acids (0.1 mg/ml), and tyrosine, phenylalanine and histidine (50 microM each) inhibited the TPO reaction by 54% or less. Histidine 271-280 thyroid peroxidase Homo sapiens 161-164 10686340-0 2000 Identification of specific histidine residues and the carboxyl terminus are essential for serotonin N-acetyltransferase enzymatic activity. Histidine 27-36 aralkylamine N-acetyltransferase Homo sapiens 90-119 10672909-4 2000 DPP IV requires an intact alpha-amino-group of the N-terminal histidine of GLP-1 in order to perform its enzymatic activity. Histidine 62-71 glucagon Rattus norvegicus 75-80 10786622-4 2000 Mammalian SC5D was presumed as an integral membrane protein containing histidine residues conserved also in yeasts and plant. Histidine 71-80 sterol-C5-desaturase Homo sapiens 10-14 8827453-0 1996 Effects of substitutions of the conserved histidine residues in human gamma-glutamyl transpeptidase. Histidine 42-51 inactive glutathione hydrolase 2 Homo sapiens 70-99 8827453-1 1996 gamma-Glutamyl transpeptidase possesses two histidine residues at positions 383 and 505 which are conserved in all mammalian and bacterial species. Histidine 44-53 inactive glutathione hydrolase 2 Homo sapiens 0-29 8822581-7 1996 The triplet GAT, coding for the amino acid residue gamma 364, was replaced by CAT, resulting in the substitution of Asp-->His. Histidine 122-125 glycine-N-acyltransferase Homo sapiens 12-15 8639599-3 1996 Holocytochrome b5, the protein with iron protoporphyrin-IX liganded to His-39 and His-63, contains in sequence the following elements of secondary structure: beta 1-alpha 1-beta 4-beta 3-alpha 2-alpha 3-beta 5-alpha 4-alpha 5-beta 2-alpha 6 [Mathews, F.S., Czerwinski, E. W., & Argos, P. (1979) The Porphyrins, Vol. Histidine 71-74 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Homo sapiens 158-240 8639599-3 1996 Holocytochrome b5, the protein with iron protoporphyrin-IX liganded to His-39 and His-63, contains in sequence the following elements of secondary structure: beta 1-alpha 1-beta 4-beta 3-alpha 2-alpha 3-beta 5-alpha 4-alpha 5-beta 2-alpha 6 [Mathews, F.S., Czerwinski, E. W., & Argos, P. (1979) The Porphyrins, Vol. Histidine 82-85 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Homo sapiens 158-240 8664285-16 1996 These findings indicate that the sulfated tyrosine/anionic GP Ibalpha residues Tyr-276-Glu-282 are important for the binding of thrombin and botrocetin-dependent binding of thrombin and the botrocetin-dependent binding of vWF, but that vWF also interacts with residues within His-1-Leu-275. Histidine 276-279 glycoprotein Ib platelet subunit alpha Homo sapiens 59-69 8605175-0 1996 The designed protein M(II)-Gly-Lys-His-Fos(138-211) specifically cleaves the AP-1 binding site containing DNA. Histidine 35-38 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 39-42 8605175-1 1996 A new specific DNA cleavage protein, Gly-Lys-His-Fos(138-211), was designed, expressed, and characterized. Histidine 45-48 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 49-52 8967341-2 1996 We performed in-gel kinase assays with His-c-jun-(1-79), which contains the amino-terminal activation domain of c-jun and a mutant His-c-jun in which Ser-63 and Ser-73 of His-c-jun were mutated to Ala as the substrates. Histidine 39-42 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 43-48 8967341-3 1996 JNK1 (p45) and JNK2 (p54) isoforms phosphorylated His-c-jun in mesangial cells. Histidine 50-53 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 54-59 8639494-0 1996 Reversal of the hydrogen bond to zinc ligand histidine-119 dramatically diminishes catalysis and enhances metal equilibration kinetics in carbonic anhydrase II. Histidine 45-54 carbonic anhydrase 2 Homo sapiens 138-159 8639500-4 1996 In the present investigation, we explore the role of all remaining charged residues by producing and characterizing mutants of ApB at Asp-7, Asp-9, Lys-37, His-39, and His-34. Histidine 156-159 arginyl aminopeptidase Homo sapiens 127-130 8639500-4 1996 In the present investigation, we explore the role of all remaining charged residues by producing and characterizing mutants of ApB at Asp-7, Asp-9, Lys-37, His-39, and His-34. Histidine 168-171 arginyl aminopeptidase Homo sapiens 127-130 8621424-5 1996 Here we show that the binding site of NT-3 to its non-preferred receptors TrkA and TrkB is dominated by two positively charged residues, Arg-31 and His-33, previously shown to constitute a main determinant of binding to p75LNGFR. Histidine 148-151 neurotrophin 3 Homo sapiens 38-42 8652624-0 1996 Proton NMR study of peptides from myelin basic protein: evidence for Lys74-His77 interaction revealed from histidine line broadening. Histidine 107-116 myelin basic protein Rattus norvegicus 34-54 8652624-3 1996 Synthetic peptides analogous to this region of MBP containing glycine and histidine are encephalitogenic if they lack the N-terminal half, residues 69-74. Histidine 74-83 myelin basic protein Rattus norvegicus 47-50 8652624-5 1996 This was investigated by measuring the 1H-NMR spectra of synthetic peptides analogous to this region of MBP, both containing histidine but with and without the N-terminal half. Histidine 125-134 myelin basic protein Rattus norvegicus 104-107 8638712-8 1996 We concluded that gastrin, acting through "gastrin/CCK-B type" receptors coupled to PTX-sensitive G protein, exerts a short-term regulation of histamine synthesis in gastric ECL cells by increasing both the affinity of HDC for L-histidine and the number of active enzyme molecules. Histidine 227-238 gastrin/cholecystokinin type B receptor Oryctolagus cuniculus 51-56 8785285-1 1996 We have previously proposed that acidification-induced regulation of the cardiac gap junction protein connexin43 (Cx43) may be modeled as a particle-receptor interaction between two separate domains of Cx43: the carboxyl terminal (acting as a particle), and a region including histidine 95 (acting as a receptor). Histidine 277-286 gap junction protein alpha 1 S homeolog Xenopus laevis 102-112 8785285-1 1996 We have previously proposed that acidification-induced regulation of the cardiac gap junction protein connexin43 (Cx43) may be modeled as a particle-receptor interaction between two separate domains of Cx43: the carboxyl terminal (acting as a particle), and a region including histidine 95 (acting as a receptor). Histidine 277-286 gap junction protein alpha 1 S homeolog Xenopus laevis 114-118 8785285-1 1996 We have previously proposed that acidification-induced regulation of the cardiac gap junction protein connexin43 (Cx43) may be modeled as a particle-receptor interaction between two separate domains of Cx43: the carboxyl terminal (acting as a particle), and a region including histidine 95 (acting as a receptor). Histidine 277-286 gap junction protein alpha 1 S homeolog Xenopus laevis 202-206 8920637-2 1996 The aim of the present study was to define the time course of changes in peptide-chain initiation, albumin synthesis, and albumin mRNA following histidine deprivation and the reversal of these changes in response to readdition of the deprived amino acid. Histidine 145-154 albumin Rattus norvegicus 122-129 8596021-8 1996 Definitive evidence for the relationship between the 55-kDa peptide and the TCR alpha-chain was obtained by transfection of the cDNA of the TCR alpha-chain with histidine tag into the 231F1 cells. Histidine 161-170 T cell receptor alpha locus Homo sapiens 76-85 8596021-8 1996 Definitive evidence for the relationship between the 55-kDa peptide and the TCR alpha-chain was obtained by transfection of the cDNA of the TCR alpha-chain with histidine tag into the 231F1 cells. Histidine 161-170 T cell receptor alpha locus Homo sapiens 140-149 1919003-2 1991 Comparison of amino acid sequences of the alpha-chain fragment of C4, C4d, has shown C4A- and C4B-specific sequences at residues 1101-1106 are the only consistent structural difference between isotype, i.e., Pro, Cys, Pro, Val, Leu, Asp in C4A and Leu, Ser, Pro, Val Ile, His in C4B. Histidine 272-275 complement C4B (Chido blood group) Homo sapiens 94-97 1918039-0 1991 Modification of histidine 56 in adrenodoxin with diethyl pyrocarbonate inhibited the interaction with cytochrome P-450scc and adrenodoxin reductase. Histidine 16-25 cholesterol side-chain cleavage enzyme, mitochondrial Bos taurus 102-121 1680393-0 1991 Involvement of the carboxy-terminal residue in the active site of the histidine-containing protein, HPr, of the phosphoenolpyruvate:sugar phosphotransferase system of Escherichia coli. Histidine 70-79 haptoglobin-related protein Homo sapiens 100-103 1680393-1 1991 Histidine-containing protein, HPr, of the Escherichia coli phosphoenolpyruvate:sugar phosphotransferase system has an active site that involves His-15, which is phosphorylated to form a N delta 1-P-histidine, Arg-17, and the carboxy-terminal residue Glu-85. Histidine 0-9 haptoglobin-related protein Homo sapiens 30-33 1680393-1 1991 Histidine-containing protein, HPr, of the Escherichia coli phosphoenolpyruvate:sugar phosphotransferase system has an active site that involves His-15, which is phosphorylated to form a N delta 1-P-histidine, Arg-17, and the carboxy-terminal residue Glu-85. Histidine 0-3 haptoglobin-related protein Homo sapiens 30-33 1889406-3 1991 Protamine HP4 contains high amounts of arginine, cysteine and histidine. Histidine 62-71 defensin alpha 4 Homo sapiens 10-13 1859409-2 1991 By considering the structure of the protease"s cDNA, we concluded that His-238 is the C-terminal residue of medullasin. Histidine 71-74 elastase, neutrophil expressed Homo sapiens 108-118 1859409-3 1991 Therefore, medullasin is composed of 238 amino acid residues with Ile as the amino terminal and His as the carboxyl terminal. Histidine 96-99 elastase, neutrophil expressed Homo sapiens 11-21 1712588-1 1991 Since the growth hormone-releasing peptide (GHRP), His-D-Trp-Ala-Trp-D-Phe-Lys-NH2, was found to specifically release growth hormone by a complementary but yet not clearly defined action on the pituitary as well as the hypothalamus, in vitro studies have been performed to demonstrate and characterized GHRP binding sites on peripheral membranes of both the rat anterior pituitary and hypothalamus. Histidine 51-54 ghrelin and obestatin prepropeptide Rattus norvegicus 10-42 1712588-1 1991 Since the growth hormone-releasing peptide (GHRP), His-D-Trp-Ala-Trp-D-Phe-Lys-NH2, was found to specifically release growth hormone by a complementary but yet not clearly defined action on the pituitary as well as the hypothalamus, in vitro studies have been performed to demonstrate and characterized GHRP binding sites on peripheral membranes of both the rat anterior pituitary and hypothalamus. Histidine 51-54 ghrelin and obestatin prepropeptide Rattus norvegicus 44-48 1712588-1 1991 Since the growth hormone-releasing peptide (GHRP), His-D-Trp-Ala-Trp-D-Phe-Lys-NH2, was found to specifically release growth hormone by a complementary but yet not clearly defined action on the pituitary as well as the hypothalamus, in vitro studies have been performed to demonstrate and characterized GHRP binding sites on peripheral membranes of both the rat anterior pituitary and hypothalamus. Histidine 51-54 ghrelin and obestatin prepropeptide Rattus norvegicus 303-307 1680656-6 1991 The pseudo-first order rate constants for inactivation of low-KM ALDH depends on both effects, suggesting that electrostatic forces are involved in the process and that a group with pK approximately 6.8, presumably a histidine residue, at the active site of ALDH could be involved. Histidine 217-226 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 65-69 1680656-6 1991 The pseudo-first order rate constants for inactivation of low-KM ALDH depends on both effects, suggesting that electrostatic forces are involved in the process and that a group with pK approximately 6.8, presumably a histidine residue, at the active site of ALDH could be involved. Histidine 217-226 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 258-262 2064618-7 1991 This residue (His-680) probably represents the active-site histidine of prolyl endopeptidase. Histidine 14-17 prolyl endopeptidase Homo sapiens 72-92 2064618-7 1991 This residue (His-680) probably represents the active-site histidine of prolyl endopeptidase. Histidine 59-68 prolyl endopeptidase Homo sapiens 72-92 1828889-7 1991 Placing the Ca2+ ATP of actin on the ATPase fragment structure suggests Asp-206 (corresponding to His-161 of actin) as a candidate proton acceptor for the ATPase reaction. Histidine 98-101 actin epsilon 1 Bos taurus 24-29 1828889-7 1991 Placing the Ca2+ ATP of actin on the ATPase fragment structure suggests Asp-206 (corresponding to His-161 of actin) as a candidate proton acceptor for the ATPase reaction. Histidine 98-101 actin epsilon 1 Bos taurus 109-114 2037047-4 1991 Alternative mechanisms of ligand stabilization may therefore be operative in Mb"s lacking the distal histidine. Histidine 101-110 myoglobin Physeter catodon 77-79 2069873-9 1991 Replacement of some of these cysteine and histidine residues completely abolished the transforming activity of vav genes. Histidine 42-51 vav guanine nucleotide exchange factor 1 Homo sapiens 111-114 1671047-5 1991 The inhibition of protein synthesis caused by histidine deprivation alone was accompanied by a 2-fold increase in the number of free ribosomal particles, a 29% decrease in Met-tRNA(i) binding to 43 S preinitiation complexes, and a 31% reduction in activity of eukaryotic initiation factor 2B (eIF-2B). Histidine 46-55 eukaryotic translation initiation factor 2B subunit delta Rattus norvegicus 260-291 1671047-5 1991 The inhibition of protein synthesis caused by histidine deprivation alone was accompanied by a 2-fold increase in the number of free ribosomal particles, a 29% decrease in Met-tRNA(i) binding to 43 S preinitiation complexes, and a 31% reduction in activity of eukaryotic initiation factor 2B (eIF-2B). Histidine 46-55 eukaryotic translation initiation factor 2B subunit delta Rattus norvegicus 293-299 1671047-6 1991 By comparison, histidine deprivation combined with histidinol addition resulted in a 3-fold increase in free ribosomal particles, a 66% decrease in Met-tRNAi binding, and a 78% reduction in eIF-2B activity. Histidine 15-24 eukaryotic translation initiation factor 2B subunit delta Rattus norvegicus 190-196 1825304-5 1991 The entire procedure of kinasing the primer, amplification by PCR, Exo lambda digestion and second step of PCR can be performed in less than 6 h. We have used this approach to generate a number of mutations in the Salmonella typhimurium hisP gene of the histidine transport operon. Histidine 254-263 exo Escherichia virus Lambda 67-70 1812710-10 1991 The positively charged histidine residues (98, 100, and 102) of kappa-casein, which are located prior to the cleavage site, appear to be able to interact with negatively charged residues of chymosin which are quite distant from the active site. Histidine 23-32 chymosin Bos taurus 190-198 1989490-9 1991 Histidinol dehydrogenase is the first histidine enzyme that has been purified to homogeneity and characterized from plants. Histidine 38-47 histidinol dehydrogenase, chloroplastic Brassica oleracea 0-24 2121465-1 1990 TRH (pGlu-His-Pro-NH2) arises from the post-translational processing of a larger precursor peptide containing multiple copies of the TRH progenitor sequence, Gln-His-Pro-Gly. Histidine 10-13 thyrotropin releasing hormone Rattus norvegicus 0-3 2121465-1 1990 TRH (pGlu-His-Pro-NH2) arises from the post-translational processing of a larger precursor peptide containing multiple copies of the TRH progenitor sequence, Gln-His-Pro-Gly. Histidine 10-13 thyrotropin releasing hormone Rattus norvegicus 133-136 2121465-1 1990 TRH (pGlu-His-Pro-NH2) arises from the post-translational processing of a larger precursor peptide containing multiple copies of the TRH progenitor sequence, Gln-His-Pro-Gly. Histidine 162-165 thyrotropin releasing hormone Rattus norvegicus 0-3 2121465-1 1990 TRH (pGlu-His-Pro-NH2) arises from the post-translational processing of a larger precursor peptide containing multiple copies of the TRH progenitor sequence, Gln-His-Pro-Gly. Histidine 162-165 thyrotropin releasing hormone Rattus norvegicus 133-136 2122435-3 1990 Bioreversible derivatization of TRH (pGlu-His-Pro-NH2) to protect the tripeptide against rapid enzymatic inactivation in the systemic circulation and to improve the lipophilicity of this highly hydrophilic peptide was performed by N-acylation of the imidazole group of the histidine residue with various chloroformates. Histidine 273-282 thyrotropin releasing hormone Homo sapiens 32-35 2122435-4 1990 Whereas TRH was rapidly hydrolyzed at its pGlu-His bond in human plasma by a TRH-specific pyroglutamyl aminopeptidase serum enzyme, the N-alkoxycarbonyl derivatives were resistant to cleavage by the enzyme. Histidine 47-50 thyrotropin releasing hormone Homo sapiens 8-11 2395880-0 1990 Substitution of a single amino acid (aspartic acid for histidine) converts the functional activity of human complement C4B to C4A. Histidine 55-64 complement C4B (Chido blood group) Homo sapiens 108-122 2198287-7 1990 The residue His-391 in the recombinant inner-core domain (E2b delta 167) was changed to Asn or Gln by site-directed mutagenesis. Histidine 12-15 dihydrolipoamide branched chain transacylase E2 Bos taurus 58-61 2118634-1 1990 The kinetics and mechanism of degradation of the tripeptide TRH (pGlu-His-Pro-NH2) and its various primary and secondary degradation products (TRH-OH, His-Pro-NH2, and His-Pro) have been determined in human plasma at 37 degrees C. The rates of degradation of both TRH and TRH-OH (pGlu-His-Pro) showed mixed zero-order and first-order kinetics. Histidine 151-154 thyrotropin releasing hormone Homo sapiens 60-63 2118634-1 1990 The kinetics and mechanism of degradation of the tripeptide TRH (pGlu-His-Pro-NH2) and its various primary and secondary degradation products (TRH-OH, His-Pro-NH2, and His-Pro) have been determined in human plasma at 37 degrees C. The rates of degradation of both TRH and TRH-OH (pGlu-His-Pro) showed mixed zero-order and first-order kinetics. Histidine 151-154 thyrotropin releasing hormone Homo sapiens 60-63 2118634-1 1990 The kinetics and mechanism of degradation of the tripeptide TRH (pGlu-His-Pro-NH2) and its various primary and secondary degradation products (TRH-OH, His-Pro-NH2, and His-Pro) have been determined in human plasma at 37 degrees C. The rates of degradation of both TRH and TRH-OH (pGlu-His-Pro) showed mixed zero-order and first-order kinetics. Histidine 151-154 thyrotropin releasing hormone Homo sapiens 60-63 2118634-3 1990 The initial step in the plasma-catalyzed degradation of TRH is due to hydrolysis of the pGlu-His bond by the TRH-specific pyroglutamyl aminopeptidase serum enzyme, resulting in the exclusive formation of histidyl-proline amide (His-Pro-NH2). Histidine 93-96 thyrotropin releasing hormone Homo sapiens 56-59 2118634-3 1990 The initial step in the plasma-catalyzed degradation of TRH is due to hydrolysis of the pGlu-His bond by the TRH-specific pyroglutamyl aminopeptidase serum enzyme, resulting in the exclusive formation of histidyl-proline amide (His-Pro-NH2). Histidine 93-96 thyrotropin releasing hormone Homo sapiens 109-112 2108187-1 1990 The acute GH release stimulated by the synthetic hexapeptide, His-DTrp-Ala-Trp-DPhe-Lys-NH2 [GH releasing peptide (GHRP)], was determined in 18 normal men and compared with the effects of GH-releasing hormone, GHRH-(1-44)-NH2. Histidine 62-65 growth hormone secretagogue receptor Homo sapiens 93-113 2108187-1 1990 The acute GH release stimulated by the synthetic hexapeptide, His-DTrp-Ala-Trp-DPhe-Lys-NH2 [GH releasing peptide (GHRP)], was determined in 18 normal men and compared with the effects of GH-releasing hormone, GHRH-(1-44)-NH2. Histidine 62-65 growth hormone secretagogue receptor Homo sapiens 115-119 2318937-5 1990 Polymorphisms in the nucleotide sequences for codons 523 (Ala), 1058 (His), and 1062 (Leu) provided useful markers to differentiate the patient"s two alleles of the insulin receptor gene. Histidine 70-73 insulin receptor Homo sapiens 165-181 2300558-2 1990 In biological systems the formation of histamine from its precursor histidine is catalyzed by the enzyme L-histidine decarboxylase (HDC; L-histidine carboxy-lyase, EC 4.1.1.22). Histidine 68-77 histidine decarboxylase Rattus norvegicus 105-130 2300558-2 1990 In biological systems the formation of histamine from its precursor histidine is catalyzed by the enzyme L-histidine decarboxylase (HDC; L-histidine carboxy-lyase, EC 4.1.1.22). Histidine 68-77 histidine decarboxylase Rattus norvegicus 132-135 33815739-3 2021 Based on docking studies and molecular dynamics simulations of the protein structure and a chondroitin substrate, we suggest a novel mechanism of DS-epi1, involving a His/double-Tyr motif. Histidine 167-170 dermatan sulfate epimerase Homo sapiens 146-153 7601289-4 1995 Magnetic/electronic asymmetry of heme induced by two axial His makes spread the hyperfine shifted heme carbon resonances over the range of 280 ppm at 25 degrees C, which would be the more sensitive probe than those of proton resonances in characterizing the nature of heme electronic structure of ferricytochrome b5. Histidine 59-62 HEME Bos taurus 33-37 7601289-4 1995 Magnetic/electronic asymmetry of heme induced by two axial His makes spread the hyperfine shifted heme carbon resonances over the range of 280 ppm at 25 degrees C, which would be the more sensitive probe than those of proton resonances in characterizing the nature of heme electronic structure of ferricytochrome b5. Histidine 59-62 HEME Bos taurus 98-102 7601289-4 1995 Magnetic/electronic asymmetry of heme induced by two axial His makes spread the hyperfine shifted heme carbon resonances over the range of 280 ppm at 25 degrees C, which would be the more sensitive probe than those of proton resonances in characterizing the nature of heme electronic structure of ferricytochrome b5. Histidine 59-62 HEME Bos taurus 98-102 34699768-3 2022 Control of hAQP10-mediated glycerol flux has been linked to the cytoplasmic end of the channel, where a unique loop is regulated by the protonation status of histidine 80 (H80). Histidine 158-167 aquaporin 10 Homo sapiens 11-17 34901149-1 2021 The fragile histidine triad (FHIT) protein is a member of the large and ubiquitous histidine triad (HIT) family of proteins. Histidine 12-21 fragile histidine triad diadenosine triphosphatase Homo sapiens 29-33 34901149-1 2021 The fragile histidine triad (FHIT) protein is a member of the large and ubiquitous histidine triad (HIT) family of proteins. Histidine 83-92 fragile histidine triad diadenosine triphosphatase Homo sapiens 29-33 34563592-4 2021 This carrier, known as the Hex carrier, is comprised of a self-assembling coiled coil hexamer at the core, with each alpha helix fused to a linker, an antibody binding domain, and a six Histidine-tag (His-tag). Histidine 186-195 hematopoietically expressed homeobox Homo sapiens 27-30 34563592-4 2021 This carrier, known as the Hex carrier, is comprised of a self-assembling coiled coil hexamer at the core, with each alpha helix fused to a linker, an antibody binding domain, and a six Histidine-tag (His-tag). Histidine 201-204 hematopoietically expressed homeobox Homo sapiens 27-30 34734351-2 2021 Histidine decarboxylase (HDC), the unique enzyme that converts L-histidine to histamine, is highly expressed in CD11b+ immature myeloid cells. Histidine 63-74 histidine decarboxylase Homo sapiens 0-23 34734351-2 2021 Histidine decarboxylase (HDC), the unique enzyme that converts L-histidine to histamine, is highly expressed in CD11b+ immature myeloid cells. Histidine 63-74 histidine decarboxylase Homo sapiens 25-28 34327612-2 2021 The obtained recombinant Mb without His-tag showed non-cooperative thermal denaturation profile. Histidine 36-39 myoglobin Oncorhynchus mykiss 25-27 34471328-0 2021 Rapid identification of histamine-producing bacteria isolated from fish using MALDI-TOF MS. Histamine-producing bacteria (HPB) produce histamine from histidine contained in food through the action of histidine decarboxylase. Histidine 150-159 histidine decarboxylase Homo sapiens 200-223 34630499-3 2021 Perception of cytokinin signaling involves (i) a hormone molecule binding to the CHASE domain, (ii) CRE1 autophosphorylation at a conserved His residue in the HK domain, followed by a phosphorelay to (iii) a conserved Asp residue in the REC domain, (iv) a histidine-containing phosphotransfer protein (HPt), and (v) a response regulator (RR). Histidine 140-143 CHASE domain containing histidine kinase protein Arabidopsis thaliana 100-104 34572578-4 2021 The genuine 4-HNE-Enzyme-Linked Immunosorbent Assay (HNE-ELISA), based on monoclonal antibody specific for HNE-histidine (HNE-His) adducts, was used to determine plasma HNE-protein conjugates. Histidine 111-120 elastase, neutrophil expressed Homo sapiens 107-110 34572578-4 2021 The genuine 4-HNE-Enzyme-Linked Immunosorbent Assay (HNE-ELISA), based on monoclonal antibody specific for HNE-histidine (HNE-His) adducts, was used to determine plasma HNE-protein conjugates. Histidine 126-129 elastase, neutrophil expressed Homo sapiens 122-125 34575967-7 2021 The functionality of His-tagged Caf1R was demonstrated in vivo, but insolubility was a problem with overproduction. Histidine 21-24 F1 capsule positive regulator Yersinia pestis 32-37 34231327-4 2021 Due to the unique properties and significant role of histidine in protein sequences, here for the first time, the tautomeric effect of histidine at the early stages of amylin misfolding was investigated via molecular dynamics simulations. Histidine 53-62 islet amyloid polypeptide Homo sapiens 168-174 34231327-4 2021 Due to the unique properties and significant role of histidine in protein sequences, here for the first time, the tautomeric effect of histidine at the early stages of amylin misfolding was investigated via molecular dynamics simulations. Histidine 135-144 islet amyloid polypeptide Homo sapiens 168-174 34350692-3 2022 Structural analyses of 1-Pro-His suggested that the peptide backbone of (SeH,SeH) is rigidly bent to form a gamma-turn, possibly including an NH Se hydrogen bond between the imidazole ring of His and selenol group, thus stabilizing the (SeH,SeH) form thermodynamically, and dramatically enhancing the catalytic activity. Histidine 194-197 epoxide hydrolase 2 Homo sapiens 73-76 34350692-3 2022 Structural analyses of 1-Pro-His suggested that the peptide backbone of (SeH,SeH) is rigidly bent to form a gamma-turn, possibly including an NH Se hydrogen bond between the imidazole ring of His and selenol group, thus stabilizing the (SeH,SeH) form thermodynamically, and dramatically enhancing the catalytic activity. Histidine 194-197 epoxide hydrolase 2 Homo sapiens 77-80 34350692-3 2022 Structural analyses of 1-Pro-His suggested that the peptide backbone of (SeH,SeH) is rigidly bent to form a gamma-turn, possibly including an NH Se hydrogen bond between the imidazole ring of His and selenol group, thus stabilizing the (SeH,SeH) form thermodynamically, and dramatically enhancing the catalytic activity. Histidine 194-197 epoxide hydrolase 2 Homo sapiens 239-242 34350692-3 2022 Structural analyses of 1-Pro-His suggested that the peptide backbone of (SeH,SeH) is rigidly bent to form a gamma-turn, possibly including an NH Se hydrogen bond between the imidazole ring of His and selenol group, thus stabilizing the (SeH,SeH) form thermodynamically, and dramatically enhancing the catalytic activity. Histidine 194-197 epoxide hydrolase 2 Homo sapiens 243-246 35254116-1 2022 BACKGROUND: Fragile histidine triad (FHIT) is a strong tumor suppressor gene, and cells deficient in FHIT are prone to acquiring cancer-promoting mutations. Histidine 20-29 fragile histidine triad diadenosine triphosphatase Homo sapiens 37-41 35254116-1 2022 BACKGROUND: Fragile histidine triad (FHIT) is a strong tumor suppressor gene, and cells deficient in FHIT are prone to acquiring cancer-promoting mutations. Histidine 20-29 fragile histidine triad diadenosine triphosphatase Homo sapiens 101-105 35578055-6 2022 The strong and stable binding of these safe and cheap vitamins at the important residues (R403, K417, Y449, Y453, N501, and Y505) in the S-protein-ACE2 interface and 3CLpro binding site residues especially active site residues (His 41 and Cys 145), indicating that they could be valuable repurpose drugs for inhibiting SARS-CoV-2 entry into the host and replication. Histidine 228-231 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 137-138 35578055-6 2022 The strong and stable binding of these safe and cheap vitamins at the important residues (R403, K417, Y449, Y453, N501, and Y505) in the S-protein-ACE2 interface and 3CLpro binding site residues especially active site residues (His 41 and Cys 145), indicating that they could be valuable repurpose drugs for inhibiting SARS-CoV-2 entry into the host and replication. Histidine 228-231 angiotensin converting enzyme 2 Homo sapiens 147-151 35151127-2 2022 The obtained Ni-NTA@SiO2 nanoflowers were used to specifically adsorb and purify His-tagged old yellow enzyme (OYE1) and glucose dehydrogenase (GDH), which allows access to optically pure (3 S)- 3-methyl-cyclohexanone through asymmetric hydrogenation reaction, and forms a cofactor regeneration system. Histidine 81-84 hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase Homo sapiens 121-142 35151127-2 2022 The obtained Ni-NTA@SiO2 nanoflowers were used to specifically adsorb and purify His-tagged old yellow enzyme (OYE1) and glucose dehydrogenase (GDH), which allows access to optically pure (3 S)- 3-methyl-cyclohexanone through asymmetric hydrogenation reaction, and forms a cofactor regeneration system. Histidine 81-84 hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase Homo sapiens 144-147 35437514-5 2022 The first approach demonstrates single-color fluorescent imaging of ACE2-GFPSpark binding to His-tagged S1-Receptor Binding Domain (RBD-His) immobilized beads. Histidine 93-96 angiotensin converting enzyme 2 Homo sapiens 68-72 35216047-0 2022 Mechanistic Insights into the Polymorphic Associations and Cross-Seeding of Abeta and hIAPP in the Presence of Histidine Tautomerism: An All-Atom Molecular Dynamic Study. Histidine 111-120 islet amyloid polypeptide Homo sapiens 86-91 35038117-6 2022 Using mutant PrP (H95A, H110A), we also investigated whether histidine residues outside the octarepeat region in PrP, which is known to bind tPA and Plg, are also involved in their binding. Histidine 61-70 plasminogen Mus musculus 149-152 35038117-9 2022 The mutant form of PrP did not stimulate Plg activation to the same degree as apo-PrP indicating that the histidine residues outside the octarepeat region are also involved in binding to tPA and Plg. Histidine 106-115 plasminogen Mus musculus 195-198 2556391-2 1989 Variant forms of mammalian gonadotropin-releasing hormone (GnRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly.NH2) are present in chicken ([Gln8] GnRH and [His5, Trp7, Tyr8]GnRH), salmon ([Trp7, Leu8]GnRH), and lamprey ([Tyr3, Leu5, Glu6, Trp7, Lys8] GnRH). Histidine 71-74 gonadotropin releasing hormone 1 Homo sapiens 27-57 2556391-2 1989 Variant forms of mammalian gonadotropin-releasing hormone (GnRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly.NH2) are present in chicken ([Gln8] GnRH and [His5, Trp7, Tyr8]GnRH), salmon ([Trp7, Leu8]GnRH), and lamprey ([Tyr3, Leu5, Glu6, Trp7, Lys8] GnRH). Histidine 71-74 gonadotropin releasing hormone 1 Homo sapiens 59-63 2556391-2 1989 Variant forms of mammalian gonadotropin-releasing hormone (GnRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly.NH2) are present in chicken ([Gln8] GnRH and [His5, Trp7, Tyr8]GnRH), salmon ([Trp7, Leu8]GnRH), and lamprey ([Tyr3, Leu5, Glu6, Trp7, Lys8] GnRH). Histidine 71-74 gonadotropin releasing hormone 1 Homo sapiens 143-147 2556391-2 1989 Variant forms of mammalian gonadotropin-releasing hormone (GnRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly.NH2) are present in chicken ([Gln8] GnRH and [His5, Trp7, Tyr8]GnRH), salmon ([Trp7, Leu8]GnRH), and lamprey ([Tyr3, Leu5, Glu6, Trp7, Lys8] GnRH). Histidine 71-74 gonadotropin releasing hormone 1 Homo sapiens 143-147 2556391-2 1989 Variant forms of mammalian gonadotropin-releasing hormone (GnRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly.NH2) are present in chicken ([Gln8] GnRH and [His5, Trp7, Tyr8]GnRH), salmon ([Trp7, Leu8]GnRH), and lamprey ([Tyr3, Leu5, Glu6, Trp7, Lys8] GnRH). Histidine 71-74 gonadotropin releasing hormone 1 Homo sapiens 143-147 2556391-2 1989 Variant forms of mammalian gonadotropin-releasing hormone (GnRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly.NH2) are present in chicken ([Gln8] GnRH and [His5, Trp7, Tyr8]GnRH), salmon ([Trp7, Leu8]GnRH), and lamprey ([Tyr3, Leu5, Glu6, Trp7, Lys8] GnRH). Histidine 71-74 gonadotropin releasing hormone 1 Homo sapiens 143-147 2512185-6 1989 These results indicate that (1) TRH accelerates metabolic rate of catecholamine in the central nervous system as well as peripheral tissues, and (2) TRH acts on both noradrenergic and dopaminergic neurons in cerebral hemisphere, diencephalon and midbrain, whereas cyclo(His-Pro) acts mainly on dopaminergic neurons in cerebellum, pons and medulla oblongata. Histidine 270-273 thyrotropin releasing hormone Rattus norvegicus 149-152 2681686-1 1989 Endopeptidase (EP) 24.15 cleaves the Tyr5-Gly6 bond of luteinizing hormone-releasing hormone (LHRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2), and is the primary LHRH degrading enzyme in pituitary and hypothalamic membrane preparations. Histidine 106-109 gonadotropin releasing hormone 1 Homo sapiens 55-92 2681686-1 1989 Endopeptidase (EP) 24.15 cleaves the Tyr5-Gly6 bond of luteinizing hormone-releasing hormone (LHRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2), and is the primary LHRH degrading enzyme in pituitary and hypothalamic membrane preparations. Histidine 106-109 gonadotropin releasing hormone 1 Homo sapiens 94-98 2681686-1 1989 Endopeptidase (EP) 24.15 cleaves the Tyr5-Gly6 bond of luteinizing hormone-releasing hormone (LHRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2), and is the primary LHRH degrading enzyme in pituitary and hypothalamic membrane preparations. Histidine 106-109 gonadotropin releasing hormone 1 Homo sapiens 167-171 2697466-4 1989 Since this DNA fragment could complement histidine auxotrophy of both C. maltosa CH1 and S. cerevisiae (his5-), we termed the gene contained in this DNA fragment C-HIS5. Histidine 41-50 histidinol-phosphate transaminase Saccharomyces cerevisiae S288C 104-108 2697466-4 1989 Since this DNA fragment could complement histidine auxotrophy of both C. maltosa CH1 and S. cerevisiae (his5-), we termed the gene contained in this DNA fragment C-HIS5. Histidine 41-50 histidinol-phosphate transaminase Saccharomyces cerevisiae S288C 164-168 2479414-0 1989 Site-directed mutagenesis of histidine-13 and histidine-114 of human angiogenin. Histidine 29-38 angiogenin Homo sapiens 69-79 2479414-0 1989 Site-directed mutagenesis of histidine-13 and histidine-114 of human angiogenin. Histidine 46-55 angiogenin Homo sapiens 69-79 2479414-2 1989 The roles of His-13 and His-114 in the ribonucleolytic and angiogenic activities of human angiogenin have been investigated by site-directed mutagenesis. Histidine 13-16 angiogenin Homo sapiens 90-100 2479414-2 1989 The roles of His-13 and His-114 in the ribonucleolytic and angiogenic activities of human angiogenin have been investigated by site-directed mutagenesis. Histidine 24-27 angiogenin Homo sapiens 90-100 2752047-2 1989 The proton NMR spectrum of the deoxy myoglobin exhibits an NH signal from the proximal histidine at 78.6 ppm, indicating heme incorporation into the heme pocket to form the Fe-N(His-F8) bond. Histidine 87-96 myoglobin Physeter catodon 37-46 2752047-2 1989 The proton NMR spectrum of the deoxy myoglobin exhibits an NH signal from the proximal histidine at 78.6 ppm, indicating heme incorporation into the heme pocket to form the Fe-N(His-F8) bond. Histidine 178-181 myoglobin Physeter catodon 37-46 2493964-2 1989 In the present study, microinjection of 10 ng to 5 micrograms of TRH into the anterior hypothalamus (AHy) dose-dependently suppressed heat production in interscapular brown adipose tissue (BAT) in chloral hydrate-anaesthetized rats tested at a room temperature of 23 +/- 2 degrees C. This effect of TRH was mimicked by the structurally related peptides acid-TRH and luteinizing hormone releasing hormone (LH-RH), and by the TRH analog CG 3509, but not by the TRH fragments pGlu-His and His-Pro. Histidine 478-481 thyrotropin releasing hormone Rattus norvegicus 65-68 15493255-5 1989 These results suggest a similar binding site on human IgG for SPA and the HSV-1 Fc receptor with involvement of the amino acid residues Tyr and His but not Lys. Histidine 144-147 surfactant protein A1 Homo sapiens 62-65 3197838-4 1988 Like human angiogenin, the bovine protein is also homologous to bovine pancreatic RNase A (34% identity) and the three major active site residues known to be involved in the catalytic process, His-14, Lys-41 and His-115, are conserved. Histidine 193-196 angiogenin Homo sapiens 11-21 3197838-4 1988 Like human angiogenin, the bovine protein is also homologous to bovine pancreatic RNase A (34% identity) and the three major active site residues known to be involved in the catalytic process, His-14, Lys-41 and His-115, are conserved. Histidine 212-215 angiogenin Homo sapiens 11-21 3076850-2 1988 It is related to several other peptides including PHI (peptide with N-terminal histidine and C-terminal isoleucine amide), secretin, glucagon, and has some sequences similar to those of growth hormone releasing hormone (Fig. Histidine 79-88 glucose-6-phosphate isomerase Homo sapiens 50-53 3141237-1 1988 Brain and spinal sites of action of the stable thyrotropin-releasing hormone (TRH) analogue, RX 77368 [pGlu-His-(3,3"-dimethyl)-Pro-NH2], for stimulation of gastric acid secretion have been investigated in urethane-anesthetized rats with gastric fistula. Histidine 108-111 thyrotropin releasing hormone Rattus norvegicus 78-81 2854108-1 1988 Histamine (HA) is synthesized from L-histidine by histidine decarboxylase (HDC), and HA released from neurons is predominantly methylated to tele-methylhistamine (t-MH), which is further metabolized by MAO. Histidine 35-46 histidine decarboxylase Rattus norvegicus 75-78 3186740-0 1988 Ligand binding to synthetic mutant myoglobin (His-E7----Gly): role of the distal histidine. Histidine 81-90 myoglobin Physeter catodon 35-44 3186740-2 1988 The synthesis and high-level expression of a sperm-whale myoglobin gene in Escherichia coli permits the efficient substitution of the distal histidine through site-directed mutagenesis. Histidine 141-150 myoglobin Physeter catodon 57-66 3346227-1 1988 The amino acid diphthamide is a complex post-translational derivative of histidine that exists in eukaryotic and Archaebacterial elongation factor 2 (EF-2). Histidine 73-82 elongation factor 2 Cricetulus griseus 129-148 3346227-1 1988 The amino acid diphthamide is a complex post-translational derivative of histidine that exists in eukaryotic and Archaebacterial elongation factor 2 (EF-2). Histidine 73-82 elongation factor 2 Cricetulus griseus 150-154 3349027-8 1988 Both His-13 and His-114 in the angiogenin peptides are required for activity since their substitution by alanine yields inactive complexes. Histidine 5-8 angiogenin Homo sapiens 31-41 3349027-8 1988 Both His-13 and His-114 in the angiogenin peptides are required for activity since their substitution by alanine yields inactive complexes. Histidine 16-19 angiogenin Homo sapiens 31-41 3126807-10 1987 We propose a revised reaction mechanism in which two histidine residues play a major role, as they do in the case of RNase A. Histidine 53-62 ribonuclease A family member 1, pancreatic Homo sapiens 117-124 3427072-3 1987 Residue His-56 in the valyl-tRNA synthetase begins a HIGH sequence, and there is a threonine at position 52, one position closer to the histidine than in the tyrosyl-tRNA synthetase. Histidine 8-11 valyl-tRNA synthetase 1 Homo sapiens 22-43 3427072-3 1987 Residue His-56 in the valyl-tRNA synthetase begins a HIGH sequence, and there is a threonine at position 52, one position closer to the histidine than in the tyrosyl-tRNA synthetase. Histidine 136-145 valyl-tRNA synthetase 1 Homo sapiens 22-43 3427072-7 1987 Thr-52 and His-56 of the valyl-tRNA synthetase contribute little binding energy to valine, ATP, and Val-AMP. Histidine 11-14 valyl-tRNA synthetase 1 Homo sapiens 25-46 3118225-6 1987 It is proposed that 29,247 molecular weight TRH prohormone, prepro TRH, which contains 5 copies of TRH sequence, can be processed to yield cyclo(His-Pro). Histidine 145-148 thyrotropin releasing hormone Homo sapiens 44-47 3118225-6 1987 It is proposed that 29,247 molecular weight TRH prohormone, prepro TRH, which contains 5 copies of TRH sequence, can be processed to yield cyclo(His-Pro). Histidine 145-148 thyrotropin releasing hormone Homo sapiens 67-70 3118225-6 1987 It is proposed that 29,247 molecular weight TRH prohormone, prepro TRH, which contains 5 copies of TRH sequence, can be processed to yield cyclo(His-Pro). Histidine 145-148 thyrotropin releasing hormone Homo sapiens 67-70 3118225-7 1987 Thus, both TRH and cyclo(His-Pro) share a common precursor, prepro[TRH/Cyclo(His-Pro)]. Histidine 25-28 thyrotropin releasing hormone Homo sapiens 67-70 3555624-2 1987 Its amino acid composition was determined and found to be very similar to that of the nonspecific lipid transfer protein from bovine and rat liver with, as main feature, the absence of arginine, histidine and tyrosine. Histidine 195-204 sterol carrier protein 2 Homo sapiens 86-120 3473473-2 1987 The TRH precursor fragment H-Lys-Arg-Gln-His-Pro-Gly-Lys-Arg-OH and the D-glutaminyl stereoisomer of H-Gln-Tyr-Ala-OH did not react under the same conditions. Histidine 41-44 thyrotropin releasing hormone Homo sapiens 4-7 3099113-4 1986 Because this last step in the biosynthesis of TRH is rate limiting for pGlu-His-Pro-Gly, we have combined several chromatographic and radioimmunoassay techniques to identify this TRH precursor in rat prostate. Histidine 76-79 thyrotropin releasing hormone Rattus norvegicus 46-49 3099113-4 1986 Because this last step in the biosynthesis of TRH is rate limiting for pGlu-His-Pro-Gly, we have combined several chromatographic and radioimmunoassay techniques to identify this TRH precursor in rat prostate. Histidine 76-79 thyrotropin releasing hormone Rattus norvegicus 179-182 3814749-3 1986 A salt bridge of this type (Glu- 9-His+ 12) was postulated previously to stabilize, to a great extent, the alpha-helical conformation of isolated N-terminal fragments of RNase A: C-peptide and S-peptide (A. Bierzynski, P.S. Histidine 35-38 ribonuclease A family member 1, pancreatic Homo sapiens 170-177 3015573-2 1986 We have previously shown that a short preincubation of explants of the median eminence area with copper(II) [Cu(II)] complexed to histidine (CuHis) markedly amplifies PGE2 stimulation of LHRH release. Histidine 130-139 gonadotropin releasing hormone 1 Homo sapiens 187-191 3527256-1 1986 A photochemically induced dynamic nuclear polarization (photo-CIDNP) study of yeast and horse muscle phosphoglycerate kinase with flavin dyes was undertaken to identify the histidine, tryptophan, and tyrosine resonances in the aromatic region of the simplified 1H NMR spectra of these enzymes and to investigate the effect of substrates on the resonances observable by CIDNP. Histidine 173-182 phosphoglycerate kinase Saccharomyces cerevisiae S288C 101-124 3718921-6 1986 This may result from extensive ion-pair interactions involving positively charged histidines and negatively charged phosphoserines, which are prevalent in the phosvitin sequence. Histidine 82-92 casein kinase 2 beta Homo sapiens 159-168 3530729-5 1986 Chicken LHRH-II, where tyrosine is replaced for histidine, has a lower affinity (0.3X) than that of mammalian LHRH. Histidine 48-57 gonadotropin releasing hormone 1 Homo sapiens 8-12 3530729-5 1986 Chicken LHRH-II, where tyrosine is replaced for histidine, has a lower affinity (0.3X) than that of mammalian LHRH. Histidine 48-57 gonadotropin releasing hormone 1 Homo sapiens 110-114 2420333-12 1986 Both release of endogenous histamine and formation of radiolabeled histamine from labeled histidine were inhibited by the histidine decarboxylase inhibitor alpha-fluoromethylhistidine (10 microM). Histidine 90-99 histidine decarboxylase Rattus norvegicus 122-145 4074786-0 1985 [Structural role of histidine residues in NAD(P)-glutamate dehydrogenase from the bovine liver]. Histidine 20-29 glutamate dehydrogenase 1, mitochondrial Bos taurus 49-72 4074786-5 1985 These data testify to the structural role of histidine residues in the GDH molecule. Histidine 45-54 glutamate dehydrogenase 1, mitochondrial Bos taurus 71-74 2933077-5 1985 Between pH 5.5 and 8, the pH profiles of kcat and kcat/Km for the Lys77-plasmin-catalyzed hydrolysis of ZLysONp and ZArgONp reflect the ionization of a single group (probably His-602 involved in the active site) with pKa values ranging between 6.4 and 6.6; at variance, values of Km are pH-independent. Histidine 175-178 plasminogen Homo sapiens 72-79 3907706-1 1985 The histidine-containing phosphocarrier protein (HPr) of the phosphoenolpyruvate:sugar phosphotransferase system, when phosphorylated, contains a 1-phosphohistidinyl (1-P-histidinyl) residue (His-15). Histidine 192-195 haptoglobin-related protein Homo sapiens 4-47 3907706-1 1985 The histidine-containing phosphocarrier protein (HPr) of the phosphoenolpyruvate:sugar phosphotransferase system, when phosphorylated, contains a 1-phosphohistidinyl (1-P-histidinyl) residue (His-15). Histidine 192-195 haptoglobin-related protein Homo sapiens 49-52 2865955-3 1985 The participation of "thyroliberinase", a metalloenzyme which cleaves TRH at the pyroglutamyl-His bond was implied. Histidine 94-97 thyrotropin releasing hormone Homo sapiens 70-73 2862917-1 1985 Kinetic studies of pig kidney dipeptidyl peptidase IV (dipeptidyl-peptide hydrolase, EC 3.4.14.5) were carried out using substrates possessing a side-chain of different length at the P2 position (or amino-terminal position in this case) such as Lys-, Arg-, Phe-, Met-, Ser-, His-, Glu- and Gly-Pro-pNA. Histidine 275-278 dipeptidyl peptidase 4 Sus scrofa 30-53 2991197-3 1985 Tox+ recombinants showed the same linkage properties to the his locus as to the previously mapped tox locus of 569B. Histidine 60-63 thymocyte selection associated high mobility group box Homo sapiens 0-3 4008494-0 1985 Resonance Raman studies of CO and O2 binding to elephant myoglobin (distal His(E7)----Gln). Histidine 75-78 myoglobin Physeter catodon 57-66 4008494-1 1985 Carbon monoxide and dioxygen were employed as resonance Raman-visible ligands for probing the nature of the heme-binding site in elephant myoglobin, which has glutamine in the distal position (E7) instead of the usual histidine. Histidine 218-227 myoglobin Physeter catodon 138-147 2861789-5 1985 We have proposed that the mixed-function oxidation system (the cytochrome P-450 system) produces Fe(II) and H2O2 which react at the metal binding site on the glutamine synthetase to generate an activated oxygen species which oxidizes a nearby susceptible histidine. Histidine 255-264 cytochrome P-450 Oryctolagus cuniculus 63-79 3927185-3 1985 On the other hand, p-Glu-His-Pro-OH (TRH-free acid), another metabolite of TRH caused significant inhibition (21%) at 10(-4) M concentration. Histidine 25-28 thyrotropin releasing hormone Rattus norvegicus 37-40 3928667-3 1985 These results suggest that hemopexin is composed of two domains that are connected by an exposed histidine-rich hinge-like region in apohemopexin which becomes inaccessible to trypsin in heme-saturated hemopexin. Histidine 97-106 hemopexin Homo sapiens 27-36 3928667-3 1985 These results suggest that hemopexin is composed of two domains that are connected by an exposed histidine-rich hinge-like region in apohemopexin which becomes inaccessible to trypsin in heme-saturated hemopexin. Histidine 97-106 hemopexin Homo sapiens 136-145 3926449-1 1985 We studied the in vitro synthesis of thyrotropin releasing hormone (TRH) by pancreatic cells, using [14C]histidine incorporation and radioimmunoassay. Histidine 105-114 thyrotropin releasing hormone Rattus norvegicus 37-66 3926449-1 1985 We studied the in vitro synthesis of thyrotropin releasing hormone (TRH) by pancreatic cells, using [14C]histidine incorporation and radioimmunoassay. Histidine 105-114 thyrotropin releasing hormone Rattus norvegicus 68-71 4050131-8 1985 Pretreatment with alpha-fluoromethylhistidine (alpha FMH), a potent and specific inhibitor of histidine decarboxylase, produced a reduction in the effects of histidine. Histidine 36-45 histidine decarboxylase Rattus norvegicus 94-117 3920663-0 1985 Intraventricular administration of cyclo(His-Pro), a metabolite of thyrotropin-releasing hormone (TRH), decreases water intake in the rat. Histidine 41-44 thyrotropin releasing hormone Rattus norvegicus 67-96 3920663-0 1985 Intraventricular administration of cyclo(His-Pro), a metabolite of thyrotropin-releasing hormone (TRH), decreases water intake in the rat. Histidine 41-44 thyrotropin releasing hormone Rattus norvegicus 98-101 3853779-1 1985 Study by chemical modification of Ser, Arg, His residues and sulfhydryl groups on bovine seryl-tRNA synthetase showed that Ser residues appeared to be unnecessary for the recognition mechanism, but Arg and His residues were essential. Histidine 44-47 seryl-tRNA synthetase 1 Bos taurus 89-110 3853779-1 1985 Study by chemical modification of Ser, Arg, His residues and sulfhydryl groups on bovine seryl-tRNA synthetase showed that Ser residues appeared to be unnecessary for the recognition mechanism, but Arg and His residues were essential. Histidine 206-209 seryl-tRNA synthetase 1 Bos taurus 89-110 6480697-1 1984 A major event in the keratinization of epidermis is the production of the histidine-rich protein filaggrin (26,000 mol wt) from its high molecular weight (greater than 350,000) phosphorylated precursor (profilaggrin). Histidine 74-83 filaggrin Mus musculus 97-106 6480697-1 1984 A major event in the keratinization of epidermis is the production of the histidine-rich protein filaggrin (26,000 mol wt) from its high molecular weight (greater than 350,000) phosphorylated precursor (profilaggrin). Histidine 74-83 filaggrin Mus musculus 203-215 6093073-5 1984 In the amygdala, binding was inhibited in the presence of TRH and Me-TRH but not in the presence of up to 1 microM concentrations of cyclo (His-Pro), TRH-OH, pGlu-His or peptides unrelated to TRH. Histidine 163-166 thyrotropin releasing hormone Homo sapiens 58-61 6472496-2 1984 This method involved conversion of [3H]histidine into [3H]histamine by the enzyme sample, with methylation of this product in situ, catalysed by the enzyme histamine N-methyltransferase, to yield [3H]N-tele-methylhistamine. Histidine 35-48 histamine N-methyltransferase Mus musculus 156-185 6374651-3 1984 Here, the beta 2 form has a histidine residue, while, in common with other characterized mammalian liver alcohol dehydrogenases, the beta 1 form has an arginine residue. Histidine 28-37 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 10-16 6374651-5 1984 The histidine/arginine-47 mutational replacement corresponds to a position that binds the pyrophosphate group of the coenzyme NAD(H); this explains the functional differences between the beta 1 beta 1 and beta 2 beta 2 isozymes, including both a lower pH optimum and higher turnover number of beta 2 beta 2, which is likely to be the mutant form. Histidine 4-13 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 205-211 6374651-5 1984 The histidine/arginine-47 mutational replacement corresponds to a position that binds the pyrophosphate group of the coenzyme NAD(H); this explains the functional differences between the beta 1 beta 1 and beta 2 beta 2 isozymes, including both a lower pH optimum and higher turnover number of beta 2 beta 2, which is likely to be the mutant form. Histidine 4-13 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 212-218 6374651-5 1984 The histidine/arginine-47 mutational replacement corresponds to a position that binds the pyrophosphate group of the coenzyme NAD(H); this explains the functional differences between the beta 1 beta 1 and beta 2 beta 2 isozymes, including both a lower pH optimum and higher turnover number of beta 2 beta 2, which is likely to be the mutant form. Histidine 4-13 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 212-218 6374651-5 1984 The histidine/arginine-47 mutational replacement corresponds to a position that binds the pyrophosphate group of the coenzyme NAD(H); this explains the functional differences between the beta 1 beta 1 and beta 2 beta 2 isozymes, including both a lower pH optimum and higher turnover number of beta 2 beta 2, which is likely to be the mutant form. Histidine 4-13 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 212-218 6427768-0 1984 Glycine-directed peptide amidation: presence in rat brain of two enzymes that convert p-Glu-His-Pro-Gly-OH into p-Glu-His-Pro-NH2 (thyrotropin-releasing hormone). Histidine 92-95 thyrotropin releasing hormone Rattus norvegicus 131-160 6717439-1 1984 Diphthamide, a unique amino acid, is a post-translational derivative of histidine that exists in protein synthesis elongation factor 2 at the site of diphtheria toxin-catalyzed ADP-ribosylation of elongation factor 2. Histidine 72-81 elongation factor 2 Cricetulus griseus 115-134 6717439-1 1984 Diphthamide, a unique amino acid, is a post-translational derivative of histidine that exists in protein synthesis elongation factor 2 at the site of diphtheria toxin-catalyzed ADP-ribosylation of elongation factor 2. Histidine 72-81 elongation factor 2 Cricetulus griseus 197-216 6371807-6 1984 Two of the five glucosamine oligosaccharides are present in a histidine-rich sequence of the middle region of the protein, in which the histidines flank beta-turns presumably at the surface of hemopexin. Histidine 62-71 hemopexin Homo sapiens 193-202 6371807-6 1984 Two of the five glucosamine oligosaccharides are present in a histidine-rich sequence of the middle region of the protein, in which the histidines flank beta-turns presumably at the surface of hemopexin. Histidine 136-146 hemopexin Homo sapiens 193-202 6712945-2 1984 Using a combination of immunologic and in vivo pulse-chase studies with radiolabeled histidine and phosphate, we show that the phosphorylated precursor of both rat and mouse filaggrin has an apparent molecular weight much higher than previously realized (6 X 10(5) and 3.9 X 10(5), respectively). Histidine 85-94 filaggrin Mus musculus 174-183 6425995-0 1984 Potent central nervous system action of p-Glu-His-(3,3"-dimethyl)-Pro NH2, a stabilized analog of TRH, to stimulate gastric secretion in rats. Histidine 46-49 thyrotropin releasing hormone Rattus norvegicus 98-101 6414519-0 1983 Proton nuclear magnetic resonance studies of histidines in horse carbonic anhydrase I. Histidine 45-55 carbonic anhydrase 1 Equus caballus 65-85 6315008-10 1983 On further fragmentation with cathepsin D, a dodecapeptide containing ADP-ribose moiety was isolated whose structure was determined as: Asp-Glu-Glu-Leu-His-Arg-Gly-Tyr-Arg*-Asp-Arg-Tyr. Histidine 152-155 cathepsin D Homo sapiens 30-41 16229164-5 1983 The "stability in vitro" toward enzymes of serum and brain homogenate of a new type of drug based on the combination of peptidic fragment of TRH-(Thyrotropin-Releasing Hormone:pGlu-His-Pro-NH2) with a non peptide moiety (dopamine) is considered and discussed. Histidine 181-184 thyrotropin releasing hormone Homo sapiens 141-175 6813375-1 1982 To generate anti-thyrotropin-releasing hormone (TRH) antibodies TRH was rendered antigenic presumably by reaction of its histidine residue with bis-diazotized benzidine (BDB) coupled to bovine serum albumin (BSA). Histidine 121-130 thyrotropin releasing hormone Oryctolagus cuniculus 12-46 6813375-1 1982 To generate anti-thyrotropin-releasing hormone (TRH) antibodies TRH was rendered antigenic presumably by reaction of its histidine residue with bis-diazotized benzidine (BDB) coupled to bovine serum albumin (BSA). Histidine 121-130 thyrotropin releasing hormone Oryctolagus cuniculus 48-51 6813375-1 1982 To generate anti-thyrotropin-releasing hormone (TRH) antibodies TRH was rendered antigenic presumably by reaction of its histidine residue with bis-diazotized benzidine (BDB) coupled to bovine serum albumin (BSA). Histidine 121-130 thyrotropin releasing hormone Oryctolagus cuniculus 64-67 6281785-1 1982 alpha-Melanocyte-stimulating hormone (alpha-melanotropin; alpha-MSH) is a linear tridecapeptide (Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2) that reversibly darkens amphibian skins by stimulating melanomsome (pigment granule) dispersion within melanophores. Histidine 120-123 pro-opiomelanocortin-alpha Mus musculus 0-36 7236849-6 1981 The observation that filling the hydrophobic vacancy on the proximal side of the heme near the proximal histidine in Met-cyano myoglobin wih cyclopropane increases the proton lability argues against the role for this hole in facilitating the flexibility of the F helix in the native protein. Histidine 104-113 myoglobin Physeter catodon 127-136 7357028-3 1980 N-Acetylhistidine accumulated preferentially in the kidney and was converted to histidine effectively by acylase I. Histidine 8-17 aminoacylase 1 Homo sapiens 105-112 7383973-6 1980 Other differences in the amino acid sequence of the rat ceruloplasmin included an increase in methionine and cystine/cysteine, and a decrease in histidine, tyrosine and tryptophan. Histidine 145-154 ceruloplasmin Rattus norvegicus 56-69 488354-0 1979 The C-terminal fragment of human glutathione reductase contains the postulated catalytic histidine. Histidine 89-98 glutathione-disulfide reductase Homo sapiens 33-54 385447-1 1979 The his1 gene in Saccharomyces cerevisiae codes for phosphoribosyl transferase, an allosteric enzyme that catalyzes the initial step in histidine biosynthesis. Histidine 136-145 ATP phosphoribosyltransferase Saccharomyces cerevisiae S288C 4-8 385447-2 1979 Mutants that specifically alter the feedback regulatory function were isolated by selecting his1 prototrophic revertants that overproduce and excrete histidine. Histidine 150-159 ATP phosphoribosyltransferase Saccharomyces cerevisiae S288C 92-96 106925-3 1979 Chromatography of TRH-like immunoreactivity obtained from Rana pipiens skin eluted in two solvent systems produced elution profiles identical with that of synthetic Pyroglu-His-Pro-NH2 consistent with reports that frog skin contains large quantities of TRH. Histidine 173-176 thyrotropin releasing hormone Homo sapiens 18-21 478976-0 1979 Hemoglobin Sunshine Seth - alpha 2 (94 (G1) Asp replaced by His) beta 2. Histidine 60-63 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 65-71 43839-0 1979 Hydrogen-tritium exchange titration of the histidine residues in bovine heart cytochrome c and analysis of their microenvironment. Histidine 43-52 LOC104968582 Bos taurus 78-90 43839-1 1979 Microenvironments of the three histidine residues located at the positions 18, 26, and 33 from the amino terminus in bovine heart cytochrome c were analysed in solution by the hydrogen-tritium exchange titration method, which has been developed in this laboratory. Histidine 31-40 LOC104968582 Bos taurus 130-142 894608-4 1977 Kinetic analysis of enzyme-catalysed histidine decarboxylation in extracts from untreated vagotomized and from histamine-treated vagotomized rats showed that the histamine-induced suppression of histidine decarboxylase activity probably reflects a reduced enzyme concentration. Histidine 37-46 histidine decarboxylase Rattus norvegicus 195-218 1220546-0 1975 Proceedings: The kinetics of complex formation between histidine and pyridoxal-5-phosphate in the presence of bacterial histidine decarboxylase. Histidine 55-64 histidine decarboxylase Homo sapiens 120-143 821746-4 1975 Of the TRH analogues tested, only two (Ser-His-Pro-NH2, Thr-His-Pro-NH2) had potent reactivity to anti-TRH serum in large dose of 100 ng/tube. Histidine 43-46 thyrotropin releasing hormone Homo sapiens 103-106 238843-8 1975 In the presence of phosphate, titration curves for the H-2 proton resonances of histidine-12 and histidine-119 of methylated RNase-A indicate binding of phosphate at the active site, but these curves continue to show deviations from the titration behaviour of native RNase-A. Histidine 80-89 ribonuclease A family member 1, pancreatic Homo sapiens 267-274 1122293-8 1975 Of the basic amino acids platelet factor 4 (molecular weight 27 100) contained 5.97% arginine, 3.18% histidine, and 12.31% lysine compared to protamine sulphate with 64.2% arginine, 0.6% lysine and no histidine. Histidine 101-110 platelet factor 4 Homo sapiens 25-42 4621760-0 1972 On the role of the histidine moiety in the structure of the thyrotropin-releasing hormone. Histidine 19-28 thyrotropin releasing hormone Homo sapiens 60-89 4989588-0 1970 Metabolism of histidine in x-irradiated rats in relation to histamine and diamine oxidase. Histidine 14-23 amine oxidase, copper containing 1 Rattus norvegicus 74-89 34032009-0 2021 beta-Actin Peptide-Based Inhibitors of Histidine Methyltransferase SETD3. Histidine 39-48 SET domain containing 3, actin histidine methyltransferase Homo sapiens 67-72 34032009-1 2021 SETD3 was recently identified as the histidine methyltransferase responsible for N 3 -methylation of His73 of beta-actin in humans. Histidine 37-46 SET domain containing 3, actin histidine methyltransferase Homo sapiens 0-5 34021366-1 2021 We have generated a mutant of C. elegans manganese superoxide dismutase at histidine 30 by site-directed mutagenesis. Histidine 75-84 superoxide dismutase 2 Homo sapiens 41-71 34022193-10 2021 Preincubation of chicken albumin with 1 mM the histidine modifying agents, 100 muM N-bromosuccinimide (NBS) and Zn(II), inhibited its Cu(II)-dependent R(+)-HDCPase activity, where as other mM aminoacids modifiers had no inhibitory effects. Histidine 47-56 albumin Gallus gallus 25-32 33625485-3 2021 Primary human umbilical vein endothelial cells (HUVECs) treated with a recombinant histidine-tagged sPRR (sPRR-His) exhibited IkappaBalpha degradation concurrent with NF-kappaB p65 activation. Histidine 83-92 RELA proto-oncogene, NF-kB subunit Homo sapiens 167-180 33576020-6 2021 In cultured HSCs, extracellular His-CYGB was endocytosed and accumulated in endosomes via clathrin-mediated pathway. Histidine 32-35 cytoglobin Mus musculus 36-40 33576020-14 2021 His-CYGB exhibited no toxicity in humanised liver chimeric PXB mice. Histidine 0-3 cytoglobin Mus musculus 4-8 33167279-6 2021 The immobilized peptide would be cleavaged by proteinase K, then the His-tag residue part will leave the surface of Au film, resulting less His-tag could bind to Ni2+ and a small SPR signal would be record. Histidine 69-72 sepiapterin reductase Homo sapiens 179-182 32603918-6 2020 Myosin light chain (MYL1 and MYL3) showed high oxidative susceptibility owing to peptidyl methionine and proline oxidation as well as acetaldehyde adduct formation on lysine or histidine residues. Histidine 177-186 myosin light chain 3 Homo sapiens 29-33 32720396-1 2020 INTRODUCTION: Permanent His bundle pacing (p-HBP) could be an alternative for traditional cardiac resynchronization therapy (CRT), but an important limitation is that p-HBP cannot always correct the left bundle branch block (LBBB). Histidine 24-27 heme binding protein 1 Homo sapiens 45-48 33046741-6 2020 Our results demonstrated that shorter and stricter reaction time was critical to approach the initial rate of NAD+-dependent desuccinylation activity in crude cell lysate systems, as compared to the desuccinylation reaction of purified His-SIRT5. Histidine 236-239 sirtuin 5 Homo sapiens 240-245 33000155-11 2020 Histidine can be decarboxylated to histamine by histidine decarboxylase. Histidine 0-9 histidine decarboxylase Homo sapiens 48-71 32805585-5 2020 Moreover, the MT-nucleation centers significantly increased in numbers, and gamma-tubulin was pulled-down in a binding assay when co-expressed with histidine-tagged-mu2 and muNS. Histidine 148-157 adaptor related protein complex 1 subunit mu 2 Homo sapiens 165-168 32350111-7 2020 We demonstrate that unique BMP15 finger residues at this site (Arg-301, Gly-304, His-307, and Met-369) enable potent activation of the SMAD2/3 pathway. Histidine 81-84 SMAD family member 2 Homo sapiens 135-142 32350116-5 2020 In this study, using truncated FUT8 constructs, immunofluorescence staining, FACS analysis, cell-surface biotinylation, proteomics, and LC-electrospray ionization MS analyses, we reveal that the SH3 domain is essential for FUT8 activity both in cells and in vitro and identified His-535 in the SH3 domain as the critical residue for enzymatic activity of FUT8. Histidine 279-282 fucosyltransferase 8 Homo sapiens 31-35 32448098-8 2021 The major hot spot amino acids involved in the binding identified by interaction analysis after simulations includes Glu 35, Tyr 83, Asp 38, Lys 31, Glu 37, His 34 amino acid residues of ACE2 receptor and Gln 493, Gln 498, Asn 487, Tyr 505 and Lys 417 residues in nCoV S-protein RBD. Histidine 157-160 angiotensin converting enzyme 2 Homo sapiens 187-191 32661472-1 2020 Endometrial carcinoma is the most common malignant tumors of the reproductive system, and fragile histidine triad (FHIT) plays an important role in multiple tumors. Histidine 98-107 fragile histidine triad diadenosine triphosphatase Homo sapiens 115-119 32237123-2 2020 With the aim of refining the target population for anti-HER2 therapies in NSCLC, we investigated the relationships between HER2 and the tumour suppressor fragile histidine triad (FHIT) in lung tumour cells. Histidine 162-171 fragile histidine triad diadenosine triphosphatase Homo sapiens 179-183 32184263-0 2020 SNAP29 mediates the assembly of histidine-induced CTP synthase filaments in proximity to the cytokeratin network. Histidine 32-41 synaptosome associated protein 29 Homo sapiens 0-6 32184263-3 2020 We have previously demonstrated that histidine (His)-mediated methylation regulates the formation of CTPS filaments to suppress enzymatic activity and preserve the CTPS protein under Gln deprivation, which promotes cancer cell growth after stress alleviation. Histidine 37-46 CTP synthase 1 Homo sapiens 101-105 32184263-3 2020 We have previously demonstrated that histidine (His)-mediated methylation regulates the formation of CTPS filaments to suppress enzymatic activity and preserve the CTPS protein under Gln deprivation, which promotes cancer cell growth after stress alleviation. Histidine 37-46 CTP synthase 1 Homo sapiens 164-168 32184263-3 2020 We have previously demonstrated that histidine (His)-mediated methylation regulates the formation of CTPS filaments to suppress enzymatic activity and preserve the CTPS protein under Gln deprivation, which promotes cancer cell growth after stress alleviation. Histidine 48-51 CTP synthase 1 Homo sapiens 101-105 32184263-3 2020 We have previously demonstrated that histidine (His)-mediated methylation regulates the formation of CTPS filaments to suppress enzymatic activity and preserve the CTPS protein under Gln deprivation, which promotes cancer cell growth after stress alleviation. Histidine 48-51 CTP synthase 1 Homo sapiens 164-168 32127621-0 2020 Author Correction: MIG1 as a positive regulator for the histidine biosynthesis pathway and as a global regulator in thermotolerant yeast Kluyveromyces marxianus. Histidine 56-65 transcription factor MIG1 Saccharomyces cerevisiae S288C 19-23 31730800-1 2020 Bile acid (BA) imbalance may be directly associated with gastric cancer and indirectly influence stomach carcinogenesis via overexpression of histidine decarboxylase (HDC), which converts histidine (His) into histamine (HIST). Histidine 142-151 histidine decarboxylase Homo sapiens 167-170 31730800-1 2020 Bile acid (BA) imbalance may be directly associated with gastric cancer and indirectly influence stomach carcinogenesis via overexpression of histidine decarboxylase (HDC), which converts histidine (His) into histamine (HIST). Histidine 199-202 histidine decarboxylase Homo sapiens 142-165 31730800-1 2020 Bile acid (BA) imbalance may be directly associated with gastric cancer and indirectly influence stomach carcinogenesis via overexpression of histidine decarboxylase (HDC), which converts histidine (His) into histamine (HIST). Histidine 199-202 histidine decarboxylase Homo sapiens 167-170 31911441-0 2020 An engineered variant of SETD3 methyltransferase alters target specificity from histidine to lysine methylation. Histidine 80-89 SET domain containing 3, actin histidine methyltransferase Homo sapiens 25-30 31911441-3 2020 In the SETD3 active site, Asn255 engages in a unique hydrogen-bonding interaction with the target histidine of actin that likely contributes to its >1300-fold greater catalytic efficiency (k cat/Km ) on histidine than on lysine. Histidine 98-107 SET domain containing 3, actin histidine methyltransferase Homo sapiens 7-12 31911441-3 2020 In the SETD3 active site, Asn255 engages in a unique hydrogen-bonding interaction with the target histidine of actin that likely contributes to its >1300-fold greater catalytic efficiency (k cat/Km ) on histidine than on lysine. Histidine 203-212 SET domain containing 3, actin histidine methyltransferase Homo sapiens 7-12 31911441-4 2020 Here, we engineered active-site variants to switch the SETD3 target specificity from histidine to lysine. Histidine 85-94 SET domain containing 3, actin histidine methyltransferase Homo sapiens 55-60 31911441-6 2020 The doubly substituted SETD3 variant exhibited a 13-fold preference for lysine over histidine. Histidine 84-93 SET domain containing 3, actin histidine methyltransferase Homo sapiens 23-28 31538680-1 2020 Genetic analysis has strongly implicated human FHIT (Fragile Histidine Triad) as a tumor suppressor gene, being mutated in a large proportion of early-stage cancers. Histidine 61-70 fragile histidine triad diadenosine triphosphatase Homo sapiens 47-51 31348608-3 2020 The lysine-arginine-ornithine binding protein (LAO) is a PBP of 238 residues that binds the basic amino acids l-arginine and l-histidine with nm and mum affinity, respectively. Histidine 125-136 interleukin 4 induced 1 Homo sapiens 4-45 31348608-3 2020 The lysine-arginine-ornithine binding protein (LAO) is a PBP of 238 residues that binds the basic amino acids l-arginine and l-histidine with nm and mum affinity, respectively. Histidine 125-136 interleukin 4 induced 1 Homo sapiens 47-50 31687022-7 2019 We also performed bioinformatic analysis to evaluate the impact of variants on MKRN3 protein structures, which showed that Ile357Met locates at the zinc-binding region (C3HC4 RING finger motif), while Glu380Lys is spatially extremely close to the C3HC4 RING finger, MKRN-specific Cys-His domain, and the third C3H1 zinc-finger motif region. Histidine 284-287 makorin ring finger protein 3 Homo sapiens 79-84 31351182-6 2019 Furthermore, one residue located at 10 A distance from the catalytic site is different between the sub-families but highly conserved within each sub-family (Asp in AOC1, His in AOC2, Thr in AOC3 and Asn in AOC4) and likely contributes to substrate selectivity. Histidine 170-173 amine oxidase copper containing 3 Homo sapiens 190-194 31351182-6 2019 Furthermore, one residue located at 10 A distance from the catalytic site is different between the sub-families but highly conserved within each sub-family (Asp in AOC1, His in AOC2, Thr in AOC3 and Asn in AOC4) and likely contributes to substrate selectivity. Histidine 170-173 amine oxidase copper containing 4, pseudogene Homo sapiens 206-210 31510033-3 2019 Moreover, the expression of tyrosine (tdc) and histidine (hdc) decarboxylases genes was evaluated by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). Histidine 47-56 histidine decarboxylase Sus scrofa 58-61 31231904-9 2019 The vertical line drawn down from the proximal His in the LAO view was a good indicator of JR1 appearance (sensitivity and specificity 84.6% and 81.6%, respectively). Histidine 47-50 interleukin 4 induced 1 Homo sapiens 58-61 31231904-10 2019 CONCLUSION: The vertical line drawn down from the proximal His in the LAO view can be employed as a boundary to avoid fast JR during ablation in AVNRT. Histidine 59-62 interleukin 4 induced 1 Homo sapiens 70-73 31150776-1 2019 Human mitochondrial matrix protein Miner2 hosts two [2Fe-2S] clusters via two CDGSH (Cys-Asp-Gly-Ser-His) motifs. Histidine 101-104 CDGSH iron sulfur domain 3 Homo sapiens 35-41 31289320-0 2019 MIG1 as a positive regulator for the histidine biosynthesis pathway and as a global regulator in thermotolerant yeast Kluyveromyces marxianus. Histidine 37-46 transcription factor MIG1 Saccharomyces cerevisiae S288C 0-4 31289320-1 2019 Kmmig1 as a disrupted mutant of MIG1 encoding a regulator for glucose repression in Kluyveromyces marxianus exhibits a histidine-auxotrophic phenotype. Histidine 119-128 transcription factor MIG1 Saccharomyces cerevisiae S288C 32-36 31289320-4 2019 Considering the fact that His4 catalyzes four of ten steps in histidine biosynthesis, K. marxianus has evolved a novel and effective regulation mechanism via Mig1 for the control of histidine biosynthesis. Histidine 62-71 transcription factor MIG1 Saccharomyces cerevisiae S288C 158-162 31289320-4 2019 Considering the fact that His4 catalyzes four of ten steps in histidine biosynthesis, K. marxianus has evolved a novel and effective regulation mechanism via Mig1 for the control of histidine biosynthesis. Histidine 182-191 transcription factor MIG1 Saccharomyces cerevisiae S288C 158-162 31144503-6 2019 First, we show that the permeabilization ability of p3, but not p1, is strongly inhibited at pH 6.0 when the conserved histidines are partially charged and H17 is predominantly neutral. Histidine 119-129 phenylalanine hydroxylase Homo sapiens 93-95 31144503-11 2019 Overall, these results provide mechanistic insights into how differences in the histidine content and amphipathicity of peptides can elicit different directionality of membrane insertion and pH-dependent permeabilization. Histidine 80-89 phenylalanine hydroxylase Homo sapiens 191-193 30744784-6 2019 Pyrroloquinoline quinone (PQQ)-dependent glucose dehydrogenase (GDH) was immobilized on the CNT surface through a genetically introduced His-tag. Histidine 137-140 hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase Homo sapiens 41-62 30744784-6 2019 Pyrroloquinoline quinone (PQQ)-dependent glucose dehydrogenase (GDH) was immobilized on the CNT surface through a genetically introduced His-tag. Histidine 137-140 hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase Homo sapiens 64-67 30826286-13 2019 Furthermore, a specific residue difference between CRFR1 subtypes (glutamate) and CRFR2beta (histidine) in this interface region may impair CRFR2beta:RAMP2 interaction by electrostatic repulsion. Histidine 93-102 corticotropin releasing hormone receptor 1 Homo sapiens 51-56 31069201-3 2019 We show that the identified IKZF1 variant (p.His195Arg) alters a completely conserved histidine residue required for the folding of the third zinc-finger of IKAROS protein, leading to a loss of characteristic immunofluorescence nuclear staining pattern. Histidine 86-95 IKAROS family zinc finger 1 Homo sapiens 28-33 31069201-3 2019 We show that the identified IKZF1 variant (p.His195Arg) alters a completely conserved histidine residue required for the folding of the third zinc-finger of IKAROS protein, leading to a loss of characteristic immunofluorescence nuclear staining pattern. Histidine 86-95 IKAROS family zinc finger 1 Homo sapiens 157-163 31010094-9 2019 Moreover, site directed mutations identified that the conserved catalytic triad of CesH might consist of Serine 86, Glutamate 199, and Histidine 227. Histidine 135-144 cesH Bacillus cereus 83-87 30586560-0 2019 Development of a novel l-histidine assay method using histamine dehydrogenase and a stable mutant of histidine decarboxylase. Histidine 23-34 histidine decarboxylase Homo sapiens 101-124 30586560-3 2019 Here, we describe a novel l-histidine quantitation assay using a combination of histidine decarboxylase (HDC) and histamine dehydrogenase (HDH) enzymes. Histidine 26-37 histidine decarboxylase Homo sapiens 80-103 30586560-3 2019 Here, we describe a novel l-histidine quantitation assay using a combination of histidine decarboxylase (HDC) and histamine dehydrogenase (HDH) enzymes. Histidine 26-37 histidine decarboxylase Homo sapiens 105-108 29989442-5 2019 DISCUSSION: This c.1056G>T mutation is located in the exostosin domain of the EXT1 protein and leads to an amino acid change of Glutamine (Gln) to Histidine (His) at position 352. Histidine 150-159 exostosin glycosyltransferase 1 Homo sapiens 81-85 29989442-5 2019 DISCUSSION: This c.1056G>T mutation is located in the exostosin domain of the EXT1 protein and leads to an amino acid change of Glutamine (Gln) to Histidine (His) at position 352. Histidine 150-153 exostosin glycosyltransferase 1 Homo sapiens 81-85 30390369-5 2019 We have previously demonstrated the unique conjugation between the dihydrolipoamide dehydrogenase (DLDH) protein and TiO2 surfaces, based on specific coordinative bonding via Cys-His-Glu-Asp motif residues. Histidine 179-182 dihydrolipoamide dehydrogenase Homo sapiens 67-97 30390369-5 2019 We have previously demonstrated the unique conjugation between the dihydrolipoamide dehydrogenase (DLDH) protein and TiO2 surfaces, based on specific coordinative bonding via Cys-His-Glu-Asp motif residues. Histidine 179-182 dihydrolipoamide dehydrogenase Homo sapiens 99-103 30785395-0 2019 Structural insights into SETD3-mediated histidine methylation on beta-actin. Histidine 40-49 SET domain containing 3, actin histidine methyltransferase Homo sapiens 25-30 30941950-1 2019 PURPOSE: The study aimed to investigate the expression level of fragile histidine triad (FHIT) in breast cancer and analyze its prognostic value. Histidine 72-81 fragile histidine triad diadenosine triphosphatase Homo sapiens 89-93 30380295-6 2018 Introduction of a solubility partner, i.e., maltose binding protein (MBP), at the N-terminus of the ATR kinase domain generated a soluble form of the protein, i.e., MBP-tagged hATR kinase domain (MBP-ATR-6X His), which was found to be catalytically active, as assessed by substrate p53 Ser-15 phosphorylation (EPPLSQEAFADLWKK). Histidine 207-210 myelin basic protein Homo sapiens 44-67 30380295-6 2018 Introduction of a solubility partner, i.e., maltose binding protein (MBP), at the N-terminus of the ATR kinase domain generated a soluble form of the protein, i.e., MBP-tagged hATR kinase domain (MBP-ATR-6X His), which was found to be catalytically active, as assessed by substrate p53 Ser-15 phosphorylation (EPPLSQEAFADLWKK). Histidine 207-210 myelin basic protein Homo sapiens 69-72 30380295-6 2018 Introduction of a solubility partner, i.e., maltose binding protein (MBP), at the N-terminus of the ATR kinase domain generated a soluble form of the protein, i.e., MBP-tagged hATR kinase domain (MBP-ATR-6X His), which was found to be catalytically active, as assessed by substrate p53 Ser-15 phosphorylation (EPPLSQEAFADLWKK). Histidine 207-210 myelin basic protein Homo sapiens 165-168 30380295-6 2018 Introduction of a solubility partner, i.e., maltose binding protein (MBP), at the N-terminus of the ATR kinase domain generated a soluble form of the protein, i.e., MBP-tagged hATR kinase domain (MBP-ATR-6X His), which was found to be catalytically active, as assessed by substrate p53 Ser-15 phosphorylation (EPPLSQEAFADLWKK). Histidine 207-210 myelin basic protein Homo sapiens 165-168 30362736-6 2018 Among the nine methylation sites, we found that the extents of methylation were significantly higher in elderly subjects at the N-terminal and His-20 of alpha-globin, and at the N-terminal and Glu-26 of beta-globin. Histidine 143-146 hemoglobin subunit alpha 2 Homo sapiens 153-165 30230320-3 2018 Here, we characterized the structural features of histidines in the chemokines CXCL8 and CXCL1 in the free, GAG heparin-bound, and CXCR2 receptor N-terminal domain-bound states using solution NMR spectroscopy. Histidine 50-60 C-X-C motif chemokine receptor 2 Homo sapiens 131-136 30109310-3 2018 Herein, MMP-2-responsive nanoprobes were prepared by immobilizing fluorescent fusion proteins on nickel ferrite nanoparticles via the His-tag nickel chelation mechanism. Histidine 134-137 matrix metallopeptidase 2 Homo sapiens 8-13 30132476-2 2018 Using model peptides, we elucidated both qualitative and quantitative aspects of the Ag+-induced alpha-helical structuring role of His- and Met-rich sequences of SilE, improving our understanding of its function within the Sil system. Histidine 131-134 STIL centriolar assembly protein Homo sapiens 162-165 29888867-3 2018 We recently identified a disulfide-bridged nonapeptide, named PTPRJ-19 (H-[Cys-His-His-Asn-Leu-Thr-His-Ala-Cys]-OH), which activates PTPRJ, thereby causing cell growth inhibition and apoptosis of both cancer and endothelial cells. Histidine 79-82 protein tyrosine phosphatase receptor type J Homo sapiens 62-67 29888867-3 2018 We recently identified a disulfide-bridged nonapeptide, named PTPRJ-19 (H-[Cys-His-His-Asn-Leu-Thr-His-Ala-Cys]-OH), which activates PTPRJ, thereby causing cell growth inhibition and apoptosis of both cancer and endothelial cells. Histidine 79-82 protein tyrosine phosphatase receptor type J Homo sapiens 133-138 29888867-3 2018 We recently identified a disulfide-bridged nonapeptide, named PTPRJ-19 (H-[Cys-His-His-Asn-Leu-Thr-His-Ala-Cys]-OH), which activates PTPRJ, thereby causing cell growth inhibition and apoptosis of both cancer and endothelial cells. Histidine 83-86 protein tyrosine phosphatase receptor type J Homo sapiens 62-67 29888867-3 2018 We recently identified a disulfide-bridged nonapeptide, named PTPRJ-19 (H-[Cys-His-His-Asn-Leu-Thr-His-Ala-Cys]-OH), which activates PTPRJ, thereby causing cell growth inhibition and apoptosis of both cancer and endothelial cells. Histidine 83-86 protein tyrosine phosphatase receptor type J Homo sapiens 133-138 29691140-4 2018 By using amine reactive fluorescent N-hydroxysuccinimidyl (NHS)-ester dyes and by direct detection with primary fluorescently conjugated anti-histidine (His-tag) antibodies against detect N-terminal His6, we show Eap subdomain Eap D3D4 specifically interacts and rapidly activates human platelets. Histidine 142-151 glutamyl aminopeptidase Homo sapiens 213-216 29991810-1 2018 The peptide/histidine transporter SLC15A3 is responsible for transporting histidine, certain dipeptide and peptidomimetics from inside the lysosome to cytosol. Histidine 12-21 solute carrier family 15, member 3 Mus musculus 34-41 29953543-4 2018 Unique to KCa3.1, activation also requires phosphorylation of a single histidine residue, His358, in the cytoplasmic region, which relieves copper-mediated inhibition of the channel. Histidine 71-80 potassium calcium-activated channel subfamily N member 4 Homo sapiens 10-16 29953543-8 2018 These results suggest that His358, the inhibitory histidine in KCa3.1, might coordinate a copper ion through a similar binding mode. Histidine 50-59 potassium calcium-activated channel subfamily N member 4 Homo sapiens 63-69 29973935-2 2018 Histamine is a monoamine synthesized from the amino acid histidine through a reaction catalyzed by the enzyme histidine decarboxylase (HDC), which removes carboxyl group from histidine. Histidine 57-66 histidine decarboxylase Homo sapiens 110-133 29973935-2 2018 Histamine is a monoamine synthesized from the amino acid histidine through a reaction catalyzed by the enzyme histidine decarboxylase (HDC), which removes carboxyl group from histidine. Histidine 57-66 histidine decarboxylase Homo sapiens 135-138 29176272-8 2018 This inverse correlation was more evident among the ADH1B His/His + ALDH2 Glu/Lys or Lys/Lys groups (-3.24 mg/dL, 95% CI, -5.03 to -1.45). Histidine 58-61 aldehyde dehydrogenase 2 family member Homo sapiens 68-73 29675012-8 2018 Interestingly, we found a sharply down-regulated enzyme [A0A068E9J3 imidazoleglycerol-phosphate dehydratase (IGPD)] involved in histidine metabolism pathway in cefquinome-treated cells. Histidine 128-137 imidazoleglycerol-phosphate dehydratase HisB Staphylococcus xylosus 68-107 29675012-8 2018 Interestingly, we found a sharply down-regulated enzyme [A0A068E9J3 imidazoleglycerol-phosphate dehydratase (IGPD)] involved in histidine metabolism pathway in cefquinome-treated cells. Histidine 128-137 imidazoleglycerol-phosphate dehydratase HisB Staphylococcus xylosus 109-113 29675012-9 2018 We demonstrated the important role of IGPD in sub-MICs cefquinome inhibiting biofilm formation of S. xylosus by gene (hisB) knockout, IGPD enzyme activity and histidine content assays. Histidine 159-168 imidazoleglycerol-phosphate dehydratase HisB Staphylococcus xylosus 38-42 29675012-10 2018 Thus, our data sheds light on important role of histidine metabolism in S. xylosus biofilm formation; especially, IGPD involved in histidine metabolism might play a crucial role in sub-MICs cefquinome inhibition of biofilm formation of S. xylosus, and we propose IGPD as an attractive protein target of cefquinome. Histidine 48-57 imidazoleglycerol-phosphate dehydratase HisB Staphylococcus xylosus 114-118 29675012-10 2018 Thus, our data sheds light on important role of histidine metabolism in S. xylosus biofilm formation; especially, IGPD involved in histidine metabolism might play a crucial role in sub-MICs cefquinome inhibition of biofilm formation of S. xylosus, and we propose IGPD as an attractive protein target of cefquinome. Histidine 131-140 imidazoleglycerol-phosphate dehydratase HisB Staphylococcus xylosus 114-118 29675012-10 2018 Thus, our data sheds light on important role of histidine metabolism in S. xylosus biofilm formation; especially, IGPD involved in histidine metabolism might play a crucial role in sub-MICs cefquinome inhibition of biofilm formation of S. xylosus, and we propose IGPD as an attractive protein target of cefquinome. Histidine 131-140 imidazoleglycerol-phosphate dehydratase HisB Staphylococcus xylosus 263-267 29414441-7 2018 Analysis of a PKCdelta structural model revealed a potential His-Cys3 zinc-binding domain adjacent to residue Thr505 and suggests that interaction with a Zn2+ ion may preclude phosphorylation at this site. Histidine 61-64 protein kinase C delta Homo sapiens 14-22 29164305-0 2018 Nuclear transport of the human aryl hydrocarbon receptor and subsequent gene induction relies on its residue histidine 291. Histidine 109-118 aryl hydrocarbon receptor Homo sapiens 31-56 29164305-4 2018 To better illuminate the ligand-mediated responses of the human AHR, we applied site-directed mutagenesis and identified histidine 291 as key residue for AHR functionality, essential for both nuclear import and target gene induction. Histidine 121-130 aryl hydrocarbon receptor Homo sapiens 64-67 29164305-4 2018 To better illuminate the ligand-mediated responses of the human AHR, we applied site-directed mutagenesis and identified histidine 291 as key residue for AHR functionality, essential for both nuclear import and target gene induction. Histidine 121-130 aryl hydrocarbon receptor Homo sapiens 154-157 29164305-6 2018 Combining these observations with our structural investigations using a homology model of the AHR-PAS B domain, we suggest a dual role of histidine 291: (1) a major role for shaping the ligand binding site including direct interactions with ligands and, (2) an essential role for the conformational dynamics of a PAS B loop, which most likely influences the association of the AHR with the AHR nuclear translocator through interference with their protein-protein interface. Histidine 138-147 aryl hydrocarbon receptor Homo sapiens 94-97 29164305-6 2018 Combining these observations with our structural investigations using a homology model of the AHR-PAS B domain, we suggest a dual role of histidine 291: (1) a major role for shaping the ligand binding site including direct interactions with ligands and, (2) an essential role for the conformational dynamics of a PAS B loop, which most likely influences the association of the AHR with the AHR nuclear translocator through interference with their protein-protein interface. Histidine 138-147 aryl hydrocarbon receptor Homo sapiens 377-380 29164305-6 2018 Combining these observations with our structural investigations using a homology model of the AHR-PAS B domain, we suggest a dual role of histidine 291: (1) a major role for shaping the ligand binding site including direct interactions with ligands and, (2) an essential role for the conformational dynamics of a PAS B loop, which most likely influences the association of the AHR with the AHR nuclear translocator through interference with their protein-protein interface. Histidine 138-147 aryl hydrocarbon receptor Homo sapiens 377-380 29220360-8 2017 We conclude that OR and site 5 histidine substitutions have divergent phenotypic impacts and that cis interactions between the OR region and the site 5 region modulate pathogenic outcomes by affecting the PrP globular domain. Histidine 31-40 prion protein Mus musculus 205-208 28969870-1 2017 SAMHD1 (sterile alpha motif and histidine (H) aspartate (D) domain-containing protein 1) is known for its antiviral activity of hydrolysing deoxynucleotides required for virus replication. Histidine 32-41 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 Homo sapiens 0-6 29058417-6 2017 The His-tagged fluorescent protein chimera consisted of a red fluorescent protein mCherry that acted as the fluorophore, the low-molecular-weight protamine peptide as the CPP, and the MMP-2 cleavage sequence fused with the hexahistidine tag, whereas the nickel ferrite nanoparticles functioned as the His-tagged protein binder and also the fluorescent quencher. Histidine 4-7 matrix metallopeptidase 2 Homo sapiens 184-189 28988621-4 2017 Although the unfractionated mixture demonstrated weaker interaction/activation of the receptor, differently oxidized isolated subspecies can lead both to stronger as well as weaker binding and activation of the histidine variant of FcgammaRIIa. Histidine 211-220 Fc gamma receptor IIa Homo sapiens 232-243 28523428-2 2017 Examination of the DNA-binding domain of Glis3 reveals that this domain contains a repeated cysteine 2/histidine 2 (Cys2/His2) zinc-finger motif in the central region where the recognized DNA sequence binds. Histidine 103-112 GLIS family zinc finger 3 Mus musculus 41-46 28874603-2 2017 We found that increased pHi enabled the tumorigenic behaviors caused by somatic arginine-to-histidine mutations, which are frequent in cancer and confer pH sensing not seen with wild-type proteins. Histidine 92-101 glucose-6-phosphate isomerase Homo sapiens 24-27 28274434-0 2017 Effect of 4-hydroxy-2-nonenal on myoglobin-mediated lipid oxidation when varying histidine content and hemin affinity. Histidine 81-90 myoglobin Physeter catodon 33-42 28400162-3 2017 Here we expressed the ALOX15 orthologs of eight different mammalian species as well as human ALOX12 and ALOX15B as recombinant his-tag fusion proteins and characterized their reaction specificity with the most abundantly occurring polyunsaturated fatty acids (PUFAs) including 5,8,11,14,17-eicosapentaenoic acid (EPA) and 4,7,10,13,16,19-docosahexaenoic acid (DHA). Histidine 127-130 arachidonate 12-lipoxygenase, 12S type Homo sapiens 93-99 28612701-6 2017 An analysis of publicly available neuraminidase gene sequences showed that viruses with histidine at position 150 were rapidly replaced by viruses with arginine at this position between 2005 and 2008, in agreement with the phenotypic data. Histidine 88-97 neuraminidase 1 Homo sapiens 34-47 28404875-1 2017 Inactivation of the fragile histidine triad (Fhit) gene has been reported in the majority of human cancers, particularly in lung cancer. Histidine 28-37 fragile histidine triad diadenosine triphosphatase Homo sapiens 45-49 28414724-2 2017 In this study, sequence alignment revealed that the His-Asp-Ser catalytic triad is embedded in the TAAHC-DIAL-GDSGGP sequence motif, establishing Bm-SP142 as a serine protease. Histidine 52-55 serine protease Bombyx mori 160-175 28414756-0 2017 Reduction in the copy number and expression level of the recurrent human papillomavirus integration gene fragile histidine triad (FHIT) predicts the transition of cervical lesions. Histidine 113-122 fragile histidine triad diadenosine triphosphatase Homo sapiens 130-134 28232482-4 2017 This network, which involves residues Asp-222, His-143, Thr-139, His-189, and structural waters, is located at the edge of PLP opposite the reactive Schiff base. Histidine 47-50 pyridoxal phosphatase Homo sapiens 123-126 28232482-4 2017 This network, which involves residues Asp-222, His-143, Thr-139, His-189, and structural waters, is located at the edge of PLP opposite the reactive Schiff base. Histidine 65-68 pyridoxal phosphatase Homo sapiens 123-126 28202392-2 2017 It is usually composed of three proteins or protein complexes, enzyme I, HPr, and enzyme II, which are phosphorylated at histidine or cysteine residues. Histidine 121-130 haptoglobin-related protein Homo sapiens 73-76 28228363-1 2017 Histidine decarboxylase (HDC) is an enzyme that converts histidine to histamine. Histidine 57-66 histidine decarboxylase Homo sapiens 0-23 28228363-1 2017 Histidine decarboxylase (HDC) is an enzyme that converts histidine to histamine. Histidine 57-66 histidine decarboxylase Homo sapiens 25-28 28228363-2 2017 Inhibition of HDC has several medical applications, and HDC inhibitors are of considerable interest for the study of histidine metabolism. Histidine 117-126 histidine decarboxylase Homo sapiens 56-59 28082676-5 2017 Miner2 contains two CDGSH motifs, and each CDGSH motif hosts a [2Fe-2S] cluster via three cysteine and one histidine residues. Histidine 107-116 CDGSH iron sulfur domain 3 Homo sapiens 0-6 28165386-5 2017 Markedly, oxidative modifications of MNSOD were identified at histidine (H54 and H55), tyrosine (Y58), tryptophan (W147, W149, W205 and W210) and asparagine (N206 and N209) residues additional to methionine. Histidine 62-71 superoxide dismutase 2 Homo sapiens 37-42 27865700-8 2017 A shift in pH, altering the protonation state of the central histidine residue impairs the adhesion of Ang II. Histidine 61-70 angiogenin Homo sapiens 103-106 28035416-5 2017 During pull-down experiments GST-pallidin was able to bind His-Ndn (an HDAC3 binding protein) in vitro. Histidine 59-62 necdin, MAGE family member Homo sapiens 63-66 28035416-5 2017 During pull-down experiments GST-pallidin was able to bind His-Ndn (an HDAC3 binding protein) in vitro. Histidine 59-62 histone deacetylase 3 Homo sapiens 71-76 27917477-6 2017 Putative Zn2+ -binding motifs within SV31 comprise aspartic acid and histidine residues. Histidine 69-78 transmembrane protein 163 Homo sapiens 37-41 27469131-7 2017 RESULTS: WES demonstrated a homozygous novel missense ASNS mutation, c.1019G > A, resulting in substitution of the highly conserved arginine residue by histidine (R340H). Histidine 155-164 asparagine synthetase (glutamine-hydrolyzing) Homo sapiens 54-58 27893431-2 2016 TDP1-mediated hydrolysis uses a nucleophilic histidine (Hisnuc) and a general acid/base histidine (Hisgab). Histidine 45-54 tyrosyl-DNA phosphodiesterase 1 Homo sapiens 0-4 27819327-8 2016 Site-directed mutagenesis experiments have implicated a basic surface including the side chains of Arg 6, His 11 and Lys 32 as potentially important in the FS50 NaV1.5 interaction. Histidine 106-109 sodium voltage-gated channel alpha subunit 5 Rattus norvegicus 161-167 27693831-2 2016 The human amylin is shown to interact with zinc ions with major contribution from the single histidine residue, which is absent in amylin from other species such as cat, rhesus and rodents. Histidine 93-102 islet amyloid polypeptide Homo sapiens 10-16 27693831-2 2016 The human amylin is shown to interact with zinc ions with major contribution from the single histidine residue, which is absent in amylin from other species such as cat, rhesus and rodents. Histidine 93-102 islet amyloid polypeptide Homo sapiens 131-137 27807034-4 2016 CNOT3 interacts with EBF1, and we identified histidine 240 in EBF1 as a critical residue for this interaction. Histidine 45-54 CCR4-NOT transcription complex, subunit 3 Mus musculus 0-5 27716783-2 2016 In this study, we first expressed mouse mature Chit1 fused with V5 and (His)6 tags at the C-terminus (Chit1-V5-His) in the cytoplasm of Escherichia coli and found that most of the expressed protein was insoluble. Histidine 72-75 chitinase 1 (chitotriosidase) Mus musculus 47-52 27716783-3 2016 In contrast, Chit1 tagged with Protein A at the N-terminus and V5-His at the C-terminus, was expressed in the periplasmic space of E. coli as a soluble protein and successfully purified. Histidine 66-69 chitinase 1 (chitotriosidase) Mus musculus 13-18 27541598-3 2016 CP has two distinct transition-metal-binding sites formed at the S100A8/S100A9 dimer interface, including a histidine-rich site composed of S100A8 residues His17 and His27 and S100A9 residues His91 and His95. Histidine 108-117 S100 calcium binding protein A8 Homo sapiens 140-146 27346274-9 2016 Mutagenesis of each amino acid difference in EC1 between BB3 receptor/BB2 receptor showed replacement of His(107) in BB3 receptor by Lys(107) (H107K-BB3 receptor-mutant) from BB2 receptor, decreased affinity 60-fold, and three replacements [H107K, E11D, G112R] decreased affinity 500-fold. Histidine 105-108 bombesin receptor subtype 3 Homo sapiens 57-60 27346274-9 2016 Mutagenesis of each amino acid difference in EC1 between BB3 receptor/BB2 receptor showed replacement of His(107) in BB3 receptor by Lys(107) (H107K-BB3 receptor-mutant) from BB2 receptor, decreased affinity 60-fold, and three replacements [H107K, E11D, G112R] decreased affinity 500-fold. Histidine 105-108 bombesin receptor subtype 3 Homo sapiens 117-120 27346274-9 2016 Mutagenesis of each amino acid difference in EC1 between BB3 receptor/BB2 receptor showed replacement of His(107) in BB3 receptor by Lys(107) (H107K-BB3 receptor-mutant) from BB2 receptor, decreased affinity 60-fold, and three replacements [H107K, E11D, G112R] decreased affinity 500-fold. Histidine 105-108 bombesin receptor subtype 3 Homo sapiens 117-120 27624082-1 2016 We present a case of a novel pathogenic variant, Hb Kalavasos [alpha91(FG3)Leu His (alpha2); HBA2: c.275T > A; p.Leu92His (NM_000517.4)]; this codon was previously numbered 91 on the alpha2-globin gene that was discovered following routine Hb A1c testing on a 65-year-old female of Cypriot origin. Histidine 79-82 hemoglobin subunit alpha 2 Homo sapiens 93-97 27624082-1 2016 We present a case of a novel pathogenic variant, Hb Kalavasos [alpha91(FG3)Leu His (alpha2); HBA2: c.275T > A; p.Leu92His (NM_000517.4)]; this codon was previously numbered 91 on the alpha2-globin gene that was discovered following routine Hb A1c testing on a 65-year-old female of Cypriot origin. Histidine 79-82 hemoglobin subunit alpha 2 Homo sapiens 186-199 26876430-3 2016 Next, we summarize the post-transcriptional mechanisms that regulate the expression of IF1 and emphasize, in addition to the regulation afforded by the protonation state of histidine residues, that the activity of IF1 as an inhibitor of the ATP synthase is also regulated by phosphorylation of a serine residue. Histidine 173-182 ATP synthase inhibitory factor subunit 1 Homo sapiens 214-217 27225845-0 2016 Hb Grifton [alpha87(F8)His Pro; HBA1: C.263A > C (or HBA2)] Causes Abnormal Pulse Oximetry Measurements. Histidine 23-26 hemoglobin subunit alpha 1 Homo sapiens 32-36 28164627-1 2016 BACKGROUND: Fragile histidine triad (FHIT), fibronectin (FN), and phosphatase and tensin homology deleted on chromosome ten (PTEN) are widely reported as having abnormal expression in malignant tumors. Histidine 20-29 fragile histidine triad diadenosine triphosphatase Homo sapiens 37-41 27328714-8 2016 Indirect ELISA revealed the ability of the sfGFP-AhR, but not the sfGFP, to bind to the immobilized dioxin with the possibility to detect such interaction by both its 6 x His and GFP tags,Competitive ELISA showed that anti-dioxin antibody was more sensitive to low dioxin concentrations than sfGFP-AhR. Histidine 171-174 aryl hydrocarbon receptor Homo sapiens 49-52 27239044-4 2016 Histamine reduction is most likely caused by increased catabolism of the histamine precursor histidine, triggered by rerouting of alanine flux from AGT to the glutamic-pyruvate transaminase (GPT, also known as the alanine-transaminase ALT). Histidine 93-102 glutamic--pyruvic transaminase Homo sapiens 159-189 27239044-4 2016 Histamine reduction is most likely caused by increased catabolism of the histamine precursor histidine, triggered by rerouting of alanine flux from AGT to the glutamic-pyruvate transaminase (GPT, also known as the alanine-transaminase ALT). Histidine 93-102 glutamic--pyruvic transaminase Homo sapiens 191-194 26854536-4 2016 One inhibitor pole locates in the phospholipid headgroup binding site and the second solvent-exposed ring binds to the His-Tag of another INPP5B molecule, while a molecule of inorganic phosphate is also present in the active site. Histidine 119-122 inositol polyphosphate-5-phosphatase B Homo sapiens 138-144 26077029-6 2016 Amino acid analysis post the exposure of hCP to SAL revealed that aspartate, histidine, lysine, threonine and tyrosine residues were particularly sensitive. Histidine 77-86 coproporphyrinogen oxidase Homo sapiens 41-44 27096786-4 2016 Expression of histidine-tagged pK205R with a molecular mass of 44 kDa was determined by 12% sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and Western blot analysis. Histidine 14-23 pK205R African swine fever virus 31-37 26164497-1 2015 Histidine decarboxylase (HDC) catalyzes the biosynthesis of histamine from L-histidine and is expressed throughout the mammalian nervous system by histaminergic neurons. Histidine 75-86 histidine decarboxylase Homo sapiens 0-23 26164497-1 2015 Histidine decarboxylase (HDC) catalyzes the biosynthesis of histamine from L-histidine and is expressed throughout the mammalian nervous system by histaminergic neurons. Histidine 75-86 histidine decarboxylase Homo sapiens 25-28 26195630-7 2015 Furthermore, when C-terminally fused to an ACE2 transmembrane anchor, the secretory N-terminal catalytic or hinge-cysteine-histidine-rich domain domains of PCSK9 were able to reduce CD81 and LDLR levels. Histidine 123-132 angiotensin converting enzyme 2 Homo sapiens 43-47 26323297-3 2015 In this study, the short form of the coiled-coil domain of SYCP1 was overexpressed in Escherichia coli with an engineered C-terminal His tag. Histidine 133-136 synaptonemal complex protein 1 Homo sapiens 59-64 26226559-0 2015 Allosteric Breakage of the Hydrogen Bond within the Dual-Histidine Motif in the Active Site of Human Pin1 PPIase. Histidine 57-66 peptidylprolyl isomerase like 3 Homo sapiens 106-112 25888783-4 2015 The results showed that the pET-BLG-LFN and pET-BLG-RFN prokaryotic expression plasmids can be constructed correctly and expressed efficiently in Escherichia coli BL21 (DE3) cells to produce the 6x His-tagged ZFN proteins that can be purified by Ni-IDA-Sefinose Column. Histidine 198-201 beta-lactoglobulin Capra hircus 48-51 26200004-3 2015 (2015) show that a histidine residue in the RNA binding pocket of RIG-I sterically excludes the cap1 structure of self RNA, thereby preventing downstream activation. Histidine 19-28 cyclase associated actin cytoskeleton regulatory protein 1 Homo sapiens 96-100 25937317-3 2015 Proteins enriched in lysine and other positively charged residues (histidine and arginine) as well as glycosaminoglycans and gangliosides bind Plg. Histidine 67-76 plasminogen Homo sapiens 143-146 25952097-5 2015 A high-level expression of the histidine-tagged thioredoxin fusion protein was obtained after 8 h of incubation. Histidine 31-40 thioredoxin Bos taurus 48-59 26055918-0 2015 Leucine and histidine independently regulate milk protein synthesis in bovine mammary epithelial cells via mTOR signaling pathway. Histidine 12-21 mechanistic target of rapamycin kinase Bos taurus 107-111 26055918-7 2015 In conclusion, the milk protein synthesis was up-regulated through activation of the mTOR pathway with the addition of Leu and His in CMEC-H. Histidine 127-130 mechanistic target of rapamycin kinase Bos taurus 85-89 25936509-4 2015 HMT activity after reserpine, pargyline and L-histidine treatment showed no differences compared to the control values. Histidine 44-55 histamine N-methyltransferase Rattus norvegicus 0-3 26137124-1 2015 The fragile histidine triad (FHIT) gene is known to be a tumor suppressor gene and the abnormal methylation of FHIT has been identified in leukemia and several solid tumors. Histidine 12-21 fragile histidine triad diadenosine triphosphatase Homo sapiens 29-33 26137124-1 2015 The fragile histidine triad (FHIT) gene is known to be a tumor suppressor gene and the abnormal methylation of FHIT has been identified in leukemia and several solid tumors. Histidine 12-21 fragile histidine triad diadenosine triphosphatase Homo sapiens 111-115 24998847-1 2015 Fragile histidine triad (FHIT) loss by the two-hit mechanism of loss of heterozygosity and promoter hypermethylation commonly occurrs in non-small cell lung cancer (NSCLC) and may confer cisplatin resistance in NSCLC cells. Histidine 8-17 fragile histidine triad diadenosine triphosphatase Homo sapiens 25-29 25811613-2 2015 Here, a micellar system employing TfR-specific 7peptide (histidine-alanine-isoleucine-tyrosine- proline-arginine-histidine, HAIYPRH, 7pep) as the targeting moiety was constructed; and its endocytosis, intracellular trafficking as well as influence on TfR expression and in vivo tumor targeting were explored in the MCF-7 tumor model. Histidine 57-66 transferrin receptor Homo sapiens 34-37 25596185-5 2015 hETHE1 contains an alphabetabetaalpha MBL-fold, which supports metal-binding by the side chains of an aspartate and two histidine residues; three water molecules complete octahedral coordination of the iron. Histidine 120-129 ETHE1 persulfide dioxygenase Homo sapiens 0-6 25596185-7 2015 The histidine and aspartate residues involved in iron-binding in ETHE1, occupy similar positions to those observed across both the zinc 1 and zinc 2 binding sites in classical MBLs. Histidine 4-13 ETHE1 persulfide dioxygenase Homo sapiens 65-70 25975556-1 2015 OBJECTIVE: To explore the interaction between folate deficiency and aberrant expression related to fragile histidine triad (FHIT) gene in the progression of cervical cancerization. Histidine 107-116 fragile histidine triad diadenosine triphosphatase Homo sapiens 124-128 25586178-9 2015 Although we identified Duox1 A-loop residues (His(1071), His(1072), and Gly(1074)) important for reducing O2 (-) release, mutations of these residues to those of Duox2 failed to convert Duox1 to an O2 (-)-releasing enzyme. Histidine 46-49 dual oxidase 1 Homo sapiens 23-28 25416551-5 2015 At acidic pH, the major contribution to the destabilization of PrP comes from the protonation of histidine 187 because its replacement by tyrosine led to more stable protein (by 4.2 kJ/mol at pH 4) with slower fibrillization. Histidine 97-106 prion protein Mus musculus 63-66 25561730-5 2015 The molecular modeling study showed that Ile(196) at transmembrane helix 2, Met(233) at ECL1, and Asn(302) at ECL2 of GLP1R have contacts with His(1) and Thr(7) of GLP-1. Histidine 143-146 glucagon like peptide 1 receptor Homo sapiens 118-123 25583361-0 2015 Histidine(7.36(305)) in the conserved peptide receptor activation domain of the gonadotropin releasing hormone receptor couples peptide binding and receptor activation. Histidine 0-9 gonadotropin releasing hormone receptor Homo sapiens 80-119 25583361-3 2015 We investigated GnRH interactions with the His(7.36(305)) residue of the GnRH receptor, using functional and computational analysis of modified GnRH receptors and peptides. Histidine 43-46 gonadotropin releasing hormone 1 Homo sapiens 16-20 25583361-3 2015 We investigated GnRH interactions with the His(7.36(305)) residue of the GnRH receptor, using functional and computational analysis of modified GnRH receptors and peptides. Histidine 43-46 gonadotropin releasing hormone 1 Homo sapiens 73-77 25583361-3 2015 We investigated GnRH interactions with the His(7.36(305)) residue of the GnRH receptor, using functional and computational analysis of modified GnRH receptors and peptides. Histidine 43-46 gonadotropin releasing hormone 1 Homo sapiens 73-77 25583361-4 2015 Non-polar His(7.36(305)) substitutions decreased receptor affinity for GnRH four- to forty-fold, whereas GnRH signaling potency was more decreased (~150-fold). Histidine 10-13 gonadotropin releasing hormone 1 Homo sapiens 71-75 25583361-5 2015 Uncharged polar His(7.36(305)) substitutions decreased GnRH potency, but not affinity. Histidine 16-19 gonadotropin releasing hormone 1 Homo sapiens 55-59 25583361-6 2015 [2-Nal(3)]-GnRH retained high affinity at receptors with non-polar His(7.36(305)) substitutions, supporting a role for His(7.36(305)) in recognizing Trp(3) of GnRH. Histidine 67-70 gonadotropin releasing hormone 1 Homo sapiens 11-15 25583361-6 2015 [2-Nal(3)]-GnRH retained high affinity at receptors with non-polar His(7.36(305)) substitutions, supporting a role for His(7.36(305)) in recognizing Trp(3) of GnRH. Histidine 119-122 gonadotropin releasing hormone 1 Homo sapiens 11-15 25373728-6 2015 Using the described method for detecting histidine and aspartic acid phosphorylations and our prostate cancer progression cell system, the potential function of NM23-H1 in suppressing metastasis with a two-component regulation system is discussed. Histidine 41-50 NME/NM23 nucleoside diphosphate kinase 1 Homo sapiens 161-168 25531836-9 2015 Mutation of His to Gln or Leu weakens the ability of resveratrol to inhibit amyloid formation by IAPP, as do mutations of Arg-11, Phe-15, or Tyr-37 to Leu, and truncation to form the variant Ac 8-37-IAPP, which removes the first seven residues to eliminate Lys-1 and the N-terminal amino group. Histidine 12-15 islet amyloid polypeptide Homo sapiens 97-101 25531836-9 2015 Mutation of His to Gln or Leu weakens the ability of resveratrol to inhibit amyloid formation by IAPP, as do mutations of Arg-11, Phe-15, or Tyr-37 to Leu, and truncation to form the variant Ac 8-37-IAPP, which removes the first seven residues to eliminate Lys-1 and the N-terminal amino group. Histidine 12-15 islet amyloid polypeptide Homo sapiens 199-203 25371203-1 2015 Thyrotropin-releasing hormone is a tripeptide that consists of 5-oxoproline, histidine, and proline. Histidine 77-86 thyrotropin releasing hormone Homo sapiens 0-29 25261590-9 2015 The specific and stable BPDE-adducts to His in SA are potential biomarkers of in vivo dose of BPDE, though this requires a considerable improved analytical sensitivity of the LC/MS-MS method. Histidine 40-43 albumin Mus musculus 47-49 25735361-1 2015 BACKGROUND: Fragile histidine triad (FHIT) gene is a tumor suppressor gene which involved in breast cancer pathogenesis. Histidine 20-29 fragile histidine triad diadenosine triphosphatase Homo sapiens 37-41 25492567-8 2015 Histamine is synthesized from l-histidine by histidine decarboxylase (HDC) in a single enzymatic step. Histidine 30-41 histidine decarboxylase Mus musculus 45-68 25492567-8 2015 Histamine is synthesized from l-histidine by histidine decarboxylase (HDC) in a single enzymatic step. Histidine 30-41 histidine decarboxylase Mus musculus 70-73 25262410-8 2014 Controlled exposure to UV light was used to produce stable linear gradients of His-tagged recombinant SDF-1alpha co-immobilized with ICAM-1 following our surface chemistry approach. Histidine 79-82 intercellular adhesion molecule 1 Mus musculus 133-139 25190478-6 2014 Comparisons of the sequences of the Lox1 and Lox2 genes in H70 with those in a line with normal lipoxygenase (HG) showed that the mutations in these genes affected a highly conserved group of six histidine residues necessary for enzymatic activity. Histidine 196-205 seed linoleate 9S-lipoxygenase-2 Glycine max 45-49 25190478-8 2014 A single point mutation (T-A) in exon 8 of Lox2 changed histidine (H532, one of the iron-binding ligands essential for Lox2 activity) to glutamine. Histidine 56-65 seed linoleate 9S-lipoxygenase-2 Glycine max 43-47 25190478-8 2014 A single point mutation (T-A) in exon 8 of Lox2 changed histidine (H532, one of the iron-binding ligands essential for Lox2 activity) to glutamine. Histidine 56-65 seed linoleate 9S-lipoxygenase-2 Glycine max 119-123 25190478-9 2014 The mutation in the Lox3 gene in H70 was a single-point mutation in exon 6 (A-G), which changed the amino acid from histidine to arginine. Histidine 116-125 seed linoleate 9S-lipoxygenase-3 Glycine max 20-24 25577831-8 2014 Some of the recombinant hZP3 with His-tag could bind affinity matrix and got purified but most of the solubilized hZP3 passed through and the reasons remained unknown. Histidine 34-37 zona pellucida glycoprotein 3 Homo sapiens 24-28 25169977-1 2014 Histidine is converted to histamine by histidine decarboxylase (HDC). Histidine 0-9 histidine decarboxylase Mus musculus 39-62 25169977-1 2014 Histidine is converted to histamine by histidine decarboxylase (HDC). Histidine 0-9 histidine decarboxylase Mus musculus 64-67 25490830-3 2014 Afterward, CS, which exhibited five different molecular weights and deacetylation degrees, was complexed with pIRES2-EGFP-hBMP2-His to form CS/pIRES2-EGFP-hBMP2-His nanoparticles; in this procedure, a desolvent method was used at different N/P ratios (amino in CS to phospho in plasmid DNA). Histidine 128-131 bone morphogenetic protein 2 Homo sapiens 122-127 25490830-3 2014 Afterward, CS, which exhibited five different molecular weights and deacetylation degrees, was complexed with pIRES2-EGFP-hBMP2-His to form CS/pIRES2-EGFP-hBMP2-His nanoparticles; in this procedure, a desolvent method was used at different N/P ratios (amino in CS to phospho in plasmid DNA). Histidine 128-131 bone morphogenetic protein 2 Homo sapiens 155-160 25490830-3 2014 Afterward, CS, which exhibited five different molecular weights and deacetylation degrees, was complexed with pIRES2-EGFP-hBMP2-His to form CS/pIRES2-EGFP-hBMP2-His nanoparticles; in this procedure, a desolvent method was used at different N/P ratios (amino in CS to phospho in plasmid DNA). Histidine 161-164 bone morphogenetic protein 2 Homo sapiens 122-127 25490830-3 2014 Afterward, CS, which exhibited five different molecular weights and deacetylation degrees, was complexed with pIRES2-EGFP-hBMP2-His to form CS/pIRES2-EGFP-hBMP2-His nanoparticles; in this procedure, a desolvent method was used at different N/P ratios (amino in CS to phospho in plasmid DNA). Histidine 161-164 bone morphogenetic protein 2 Homo sapiens 155-160 25490830-7 2014 2) CS/pIRES2-EGFP-hBMP2-His nanoparticles were synthesized and pIRES2-EGFP-hBMP2-His was packaged by CS. Histidine 24-27 bone morphogenetic protein 2 Homo sapiens 18-23 25490830-7 2014 2) CS/pIRES2-EGFP-hBMP2-His nanoparticles were synthesized and pIRES2-EGFP-hBMP2-His was packaged by CS. Histidine 81-84 bone morphogenetic protein 2 Homo sapiens 18-23 25490830-7 2014 2) CS/pIRES2-EGFP-hBMP2-His nanoparticles were synthesized and pIRES2-EGFP-hBMP2-His was packaged by CS. Histidine 81-84 bone morphogenetic protein 2 Homo sapiens 75-80 25056690-3 2014 Brain histamine is synthesized from L-histidine in the presence of histidine decarboxylase, which is expressed in histamine neurons. Histidine 36-47 histidine decarboxylase Mus musculus 67-90 24805197-1 2014 The Ser96Ala (S96A) mutation within the histidine rich Ca(2+) binding protein (HRC) has recently been linked to cardiac arrhythmias in idiopathic dilated cardiomyopathy patients, potentially attributable to an increase in spontaneous Ca(2+) release events. Histidine 40-49 histidine rich calcium binding protein Homo sapiens 79-82 25042711-7 2014 His-tag-containing recombinant human glucose-6-phosphate isomerase in combination with an anti-His-tag monoclonal antibody was instrumental to develop the method. Histidine 0-3 glucose-6-phosphate isomerase Homo sapiens 37-66 25010646-8 2014 Histidine-tagged TTP proteins were purified with Ni-NTA affinity beads and digested with trypsin and lysyl endopeptidase. Histidine 0-9 ZFP36 ring finger protein Homo sapiens 17-20 25114673-7 2014 RESULTS: The C/T polymorphism at His 1058 in exon 17 of INSR was associated with PCOS (obese and non-obese). Histidine 33-36 insulin receptor Homo sapiens 56-60 24754256-1 2014 Membrane transporter PhT2 (SLC15A3), which belongs to the proton-coupled oligopeptide transporter family, mediates the transport of di/tripeptides and histidine utilizing an inwardly directed proton gradient and negative membrane potential. Histidine 151-160 solute carrier family 15, member 3 Mus musculus 27-34 24799395-6 2014 Bond Critical Points (BCP) information between the minor groove of the DNA and the metallopeptides shows an increase in electronic density between Gly(1) , the His residues, and the oxygen atoms of the thymine nucleotide. Histidine 160-163 threonine aldolase 1, pseudogene Homo sapiens 147-153 24692542-9 2014 These results indicate that the side chains of His(281) and Ser(524) are in close proximity and contribute to a bonding interaction in FVIII that is retained in FVIIIa. Histidine 47-50 coagulation factor VIII Homo sapiens 135-140 24627494-0 2014 A histidine-rich linker region in peptidylglycine alpha-amidating monooxygenase has the properties of a pH sensor. Histidine 2-11 peptidylglycine alpha-amidating monooxygenase Mus musculus 34-79 24627494-3 2014 We explored the hypothesis that a conserved His-rich cluster (His-Gly-His-His) in the linker region connecting its two catalytic domains senses pH and affects PAM trafficking by mutating these His residues to Ala (Ala-Gly-Ala-Ala; H3A). Histidine 44-47 peptidylglycine alpha-amidating monooxygenase Mus musculus 159-162 24627494-3 2014 We explored the hypothesis that a conserved His-rich cluster (His-Gly-His-His) in the linker region connecting its two catalytic domains senses pH and affects PAM trafficking by mutating these His residues to Ala (Ala-Gly-Ala-Ala; H3A). Histidine 62-65 peptidylglycine alpha-amidating monooxygenase Mus musculus 159-162 24627494-3 2014 We explored the hypothesis that a conserved His-rich cluster (His-Gly-His-His) in the linker region connecting its two catalytic domains senses pH and affects PAM trafficking by mutating these His residues to Ala (Ala-Gly-Ala-Ala; H3A). Histidine 62-65 peptidylglycine alpha-amidating monooxygenase Mus musculus 159-162 24627494-3 2014 We explored the hypothesis that a conserved His-rich cluster (His-Gly-His-His) in the linker region connecting its two catalytic domains senses pH and affects PAM trafficking by mutating these His residues to Ala (Ala-Gly-Ala-Ala; H3A). Histidine 62-65 peptidylglycine alpha-amidating monooxygenase Mus musculus 159-162 24627494-3 2014 We explored the hypothesis that a conserved His-rich cluster (His-Gly-His-His) in the linker region connecting its two catalytic domains senses pH and affects PAM trafficking by mutating these His residues to Ala (Ala-Gly-Ala-Ala; H3A). Histidine 62-65 peptidylglycine alpha-amidating monooxygenase Mus musculus 159-162 25059370-1 2014 OBJECTIVE: To explore the effect of folate on cell proliferation and apoptosis as well as on DNA methylation, expression of mRNA and protein of fragile histidine triad (FHIT)gene in cervical cancer cells. Histidine 152-161 fragile histidine triad diadenosine triphosphatase Homo sapiens 169-173 24771692-5 2014 Nkx2-5(+/-) hearts had a prolonged atrio-His interval compared to the wild type, consistent with previous in vivo observations. Histidine 41-44 NK2 homeobox 5 Mus musculus 0-6 24523290-6 2014 Thus these findings identify a novel mechanism by which TRPV5 and Ca(2+) reabsorption is regulated by the kidney and support the idea that histidine phosphorylation plays other, yet-uncovered roles in mammalian biology. Histidine 139-148 transient receptor potential cation channel subfamily V member 5 Homo sapiens 56-61 24129980-2 2014 In mammals, histamine is formed by decarboxylation of L-histidine, which is catalyzed by pyridoxal-5"-phosphate (PLP) dependent histidine decarboxylase (HDC, EC 4.1.1.22). Histidine 54-65 histidine decarboxylase Homo sapiens 128-151 24129980-2 2014 In mammals, histamine is formed by decarboxylation of L-histidine, which is catalyzed by pyridoxal-5"-phosphate (PLP) dependent histidine decarboxylase (HDC, EC 4.1.1.22). Histidine 54-65 histidine decarboxylase Homo sapiens 153-156 24384130-1 2014 Histamine is formed by the conversion of l-histidine into histamine by histidine decarboxylase (HDC). Histidine 41-52 histidine decarboxylase Mus musculus 71-94 24384130-1 2014 Histamine is formed by the conversion of l-histidine into histamine by histidine decarboxylase (HDC). Histidine 41-52 histidine decarboxylase Mus musculus 96-99 24374040-4 2014 Two polymorphisms of LMP2-60 (Arg His) and LMP7-145 (Gln Lys) were identified by PCR-RFLP (RFLP, restriction fragment length polymorphism) method. Histidine 34-37 proteasome 20S subunit beta 9 Homo sapiens 21-25 24396396-1 2014 The aim of this study was to investigate the methylation status of fragile histidine triad (FHIT) and the effects of FHIT on cell growth and cyclin D1 expression in hepatoma cells. Histidine 75-84 fragile histidine triad diadenosine triphosphatase Homo sapiens 92-96 24338687-6 2014 X-ray crystallographic studies of chronophin(A194K,A195K) revealed that dimer formation is essential for an intermolecular arginine-arginine-tryptophan stacking interaction that positions a critical histidine residue in the substrate specificity loop of chronophin for PLP coordination. Histidine 199-208 pyridoxal phosphatase Homo sapiens 34-44 24282278-8 2014 Moreover, His-MDA-7, after binding to its cognate receptors (IL-20R1/IL-20R2 or IL-22R/IL-20R2), induces intracellular signaling by phosphorylation of p38 MAPK, leading to transcription of a family of growth arrest and DNA damage inducible (GADD) genes, culminating in apoptosis. Histidine 10-13 interleukin 20 receptor subunit beta Homo sapiens 69-76 24282278-8 2014 Moreover, His-MDA-7, after binding to its cognate receptors (IL-20R1/IL-20R2 or IL-22R/IL-20R2), induces intracellular signaling by phosphorylation of p38 MAPK, leading to transcription of a family of growth arrest and DNA damage inducible (GADD) genes, culminating in apoptosis. Histidine 10-13 interleukin 22 receptor subunit alpha 1 Homo sapiens 80-86 24282278-8 2014 Moreover, His-MDA-7, after binding to its cognate receptors (IL-20R1/IL-20R2 or IL-22R/IL-20R2), induces intracellular signaling by phosphorylation of p38 MAPK, leading to transcription of a family of growth arrest and DNA damage inducible (GADD) genes, culminating in apoptosis. Histidine 10-13 interleukin 20 receptor subunit beta Homo sapiens 87-94 25430456-2 2014 Molecular modeling of PPDKs from divergent organisms demonstrates that the orientation of the phosphorylatable histidine residue within the central domain of PPDK determines whether this enzyme promotes catabolism or gluconeogenesis. Histidine 111-120 pyruvate, phosphate dikinase 1, chloroplastic Zea mays 22-26 24140098-6 2014 Wild-type and mutant CYP17A1 cDNAs were inserted into the pcDNA3.1/V5-His-P450c17 vector, and transiently expressed in COS-7 cells. Histidine 70-73 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 74-81 24349317-5 2013 Interestingly, Gln(40) and His(64) on ECP formed a clamp-like structure to stabilize Hep6 in our model, which was not observed in the corresponding residues on EDN. Histidine 27-30 ribonuclease A family member 2 Homo sapiens 160-163 24579380-5 2013 A histidine residue, which is conserved across all functional sucrose transporter proteins in higher plants, is located at position 66 of the BnSUT1C. Histidine 2-11 sucrose transport protein SUC1 Brassica napus 62-81 24579380-5 2013 A histidine residue, which is conserved across all functional sucrose transporter proteins in higher plants, is located at position 66 of the BnSUT1C. Histidine 2-11 sucrose transport protein SUC1 Brassica napus 142-149 24056255-4 2013 The gene encoding the ESAT-6 of M. tuberculosis was inserted into a bacterial expression vector pET23a (+) resulting in a 6 x His-esat-6 fusion gene construction with histidine tag at its C-terminus. Histidine 126-129 ESAT-6 protein EsxA Mycobacterium tuberculosis H37Rv 22-28 24056255-4 2013 The gene encoding the ESAT-6 of M. tuberculosis was inserted into a bacterial expression vector pET23a (+) resulting in a 6 x His-esat-6 fusion gene construction with histidine tag at its C-terminus. Histidine 167-176 ESAT-6 protein EsxA Mycobacterium tuberculosis H37Rv 22-28 24121506-5 2013 Within L1C domains, five amino acid residues (Leu-135, Gly-188, Arg-244, and vicinal His-318 and Lys-319) were identified as IRR-specific by species conservation analysis of the IR family. Histidine 85-88 insulin receptor Homo sapiens 125-127 23995934-10 2013 The two major clades within the MAR4 lineage displayed distinct patterns in the structural classes and the number and amount of HIs produced, suggesting a relationship between taxonomy and secondary metabolite production. Histidine 128-131 retrotransposon Gag like 4 Homo sapiens 32-36 21962529-6 2013 Simultaneously, the allelic deletion status of fragile histidine triad (FHIT) gene was studied by FISH in cRCC and major epithelial carcinoma (MEC) tumors. Histidine 55-64 fragile histidine triad diadenosine triphosphatase Homo sapiens 72-76 24086630-10 2013 T cells from hi-dose sensitized mice showed a robust increase in TGF-b production, and Treg from these mice were able to efficiently suppress effector T cell proliferation in vitro. Histidine 13-15 transforming growth factor, beta 1 Mus musculus 65-70 24043698-6 2013 http://dx.doi.org/10.1083/jcb.201308034) show that pHi increase activates FAK by causing deprotonation of histidine 58 in its FERM (band 4.1, ezrin, radixin, moesin) homology domain, which exposes a region important for FAK autophosphorylation. Histidine 106-115 glucose-6-phosphate isomerase Homo sapiens 51-54 24043698-6 2013 http://dx.doi.org/10.1083/jcb.201308034) show that pHi increase activates FAK by causing deprotonation of histidine 58 in its FERM (band 4.1, ezrin, radixin, moesin) homology domain, which exposes a region important for FAK autophosphorylation. Histidine 106-115 protein tyrosine kinase 2 Homo sapiens 74-77 24043698-6 2013 http://dx.doi.org/10.1083/jcb.201308034) show that pHi increase activates FAK by causing deprotonation of histidine 58 in its FERM (band 4.1, ezrin, radixin, moesin) homology domain, which exposes a region important for FAK autophosphorylation. Histidine 106-115 protein tyrosine kinase 2 Homo sapiens 220-223 23989155-3 2013 In this study, the human TRAF4 TRAF domain, corresponding to amino acids 290-470, was overexpressed in Escherichia coli using engineered C-terminal His tags. Histidine 148-151 TNF receptor associated factor 4 Homo sapiens 25-30 23797051-3 2013 Here, we attempt to corroborate and provide further insight pertinent to the fragile histidine triad (FHIT) gene in microsatellite instable (MSI), microsatellite stable (MSS), and CpG island methylator phenotype (CIMP) CRC subtypes. Histidine 85-94 fragile histidine triad diadenosine triphosphatase Homo sapiens 102-106 24200155-1 2013 Histamine is synthesized as a low-molecular-weight amine from L-histidine by histidine decarboxylase (HDC). Histidine 62-73 histidine decarboxylase Mus musculus 77-100 24200155-1 2013 Histamine is synthesized as a low-molecular-weight amine from L-histidine by histidine decarboxylase (HDC). Histidine 62-73 histidine decarboxylase Mus musculus 102-105 23818523-8 2013 However, PEDF-R polypeptides without the His(203)-Leu(232) region lost the PEDF affinity that stimulated their enzymatic activity. Histidine 41-44 serpin family F member 1 Homo sapiens 9-13 23947369-2 2013 The Fhit protein is a member of the ubiquitous histidine triad proteins which hydrolyze dinucleoside polyphosphates such as Ap3A. Histidine 47-56 fragile histidine triad diadenosine triphosphatase Homo sapiens 4-8 23720381-4 2013 The method is applied to histidine where it is able to predict atomic multipole moments (up to hexadecapole) for unseen configurations, after training on 600 geometries distorted using normal modes of each of its 24 local energy minima at B3LYP/apc-1 level. Histidine 25-34 solute carrier family 25 member 24 Homo sapiens 245-250 23773890-7 2013 The inhibition profile suggested that L-type amino acid transporter (LAT1/SLC7A5) is responsible for the influx transport of l-histidine across the inner BRB. Histidine 125-136 solute carrier family 7 member 5 Rattus norvegicus 74-80 23754285-10 2013 Interestingly, the proteolytic activity of mature ADAMDEC1 can be significantly enhanced when a canonical ADAM active site with three zinc-coordinating histidine residues is introduced. Histidine 152-161 ADAM like decysin 1 Homo sapiens 50-58 23592749-0 2013 Histidines in potential substrate recognition sites affect thyroid hormone transport by monocarboxylate transporter 8 (MCT8). Histidine 0-10 solute carrier family 16 member 2 Canis lupus familiaris 88-117 23592749-0 2013 Histidines in potential substrate recognition sites affect thyroid hormone transport by monocarboxylate transporter 8 (MCT8). Histidine 0-10 solute carrier family 16 member 2 Canis lupus familiaris 119-123 23664973-6 2013 Domain-swapping and site-directed mutagenesis of GCY-14 reveal that GCY-14 functions as a homodimer, in which histidine of the extracellular domains plays a crucial role in alkalinity detection. Histidine 110-119 Receptor-type guanylate cyclase gcy-14 Caenorhabditis elegans 49-55 23664973-6 2013 Domain-swapping and site-directed mutagenesis of GCY-14 reveal that GCY-14 functions as a homodimer, in which histidine of the extracellular domains plays a crucial role in alkalinity detection. Histidine 110-119 Receptor-type guanylate cyclase gcy-14 Caenorhabditis elegans 68-74 23280549-4 2013 Biochemical pull down assays using secreted GDF-15 and His-tagged CCN2 produced in PC-3 prostate cancer cells confirmed a direct interaction between these proteins. Histidine 55-58 cellular communication network factor 2 Homo sapiens 66-70 23560482-6 2013 Substantial production of NH2Cl from l-arginine and l-histidine was observed at Cl/P = 1.0 and 2.0 when post-chlorination was applied to UV254-irradiated samples. Histidine 52-63 cleavage factor polyribonucleotide kinase subunit 1 Homo sapiens 80-88 23671581-4 2013 Here, we document, for the first time, that the aminocoumarin antibiotic, novobiocin, directly blocks the protein-protein interaction between the HIF1alpha C-terminal activation domain (CTAD) and the cysteine-histidine rich (CH1) region of p300/CBP. Histidine 209-218 E1A binding protein p300 Homo sapiens 240-244 23592920-17 2013 Sequencing of the 12 coding exons and splice sites of CRB1 disclosed a homozygous missense mutation in exon 7 at nucleotide c. 2291G>A, resulting in an arginine to histidine substitution (p.R764H). Histidine 167-176 crumbs cell polarity complex component 1 Homo sapiens 54-58 22760783-4 2013 CaCDPK1 expressed as histidine-tag fusion protein was purified using Ni-NTA affinity chromatography till homogeneity. Histidine 21-30 calcium-dependent protein kinase 21-like Cicer arietinum 0-7 23407638-6 2013 The inhibited complex was recovered with residues 1-60 of bovine IF1 with a C-terminal green fluorescent protein followed by a His-tag, and the active enzyme with the same inhibitor with a C-terminal glutathione-S-transferase domain. Histidine 127-130 ATP synthase inhibitory factor subunit 1 Bos taurus 65-68 23385758-1 2013 Histidine-containing phosphotransfer proteins from Arabidopsis thaliana (AHP1-5) act as intermediates between sensor histidine kinases and response regulators in a signalling system called multi-step phosphorelay (MSP). Histidine 0-9 histidine-containing phosphotransmitter 1 Arabidopsis thaliana 73-77 23617075-10 2013 The LOX-2 showed conserved six Histidine residues within a span of 520 to 590 amino acid position, a signature element for the enzyme activity. Histidine 31-40 seed linoleate 9S-lipoxygenase-2 Glycine max 4-9 23249748-3 2013 We previously demonstrated that yeast strains depleted of tRNA(His) guanylyltransferase accumulate uncharged tRNA(His) lacking the G(-1) residue and subsequently accumulate additional 5-methylcytidine (m(5)C) at residues C(48) and C(50) of tRNA(His), due to the activity of the m(5)C-methyltransferase Trm4. Histidine 63-66 tRNA (cytosine-C5-)-methyltransferase Saccharomyces cerevisiae S288C 302-306 23282202-4 2013 The longer CYC-2.2 has a lower thermodynamic stability than CYC-2.1 and lacks His residues to misligate to the heme in the protein"s denatured state. Histidine 78-81 putative cytochrome c 2.2 Caenorhabditis elegans 11-18 23256819-5 2013 Thus, while the modification of proteins or peptides in solution takes several days to lead to a significant amount of modification, in RHE the modifications of nucleophilic amino acids were observable already at 24 h. The chemioselectivity also appeared to be different with major modifications taking place on histidine, methionine, and cysteine residues in RHE, while on HSA, significant modifications were observed on lysine residues with the formation of methylated and dimethylated amino groups. Histidine 312-321 factor interacting with PAPOLA and CPSF1 Homo sapiens 136-139 23195954-2 2013 We demonstrate unknown facets of calnuc, which is a serine protease in which Ser-378 of GXSXG motif, Asp-328 of DTG motif, and His-339 form the "catalytic triad," locating the enzyme active site in the C-terminal region. Histidine 127-130 nucleobindin 1 Homo sapiens 33-39 23102829-1 2013 The fragile histidine triad protein, Fhit, has a number of reported tumor suppressive functions which include signaling of apoptosis in cancer cells in vitro and in vivo, modulation of the DNA damage response, down-regulation of target oncogene expression, suppression of tumor growth in vivo, and suppression of cancer cell invasion and metastasis. Histidine 12-21 fragile histidine triad diadenosine triphosphatase Homo sapiens 37-41 23163895-6 2013 The introduction of point mutations at the "active site" of MK-STYX that convert serine and phenylalanine to histidine and cysteine, respectively, is sufficient to generate an active enzyme. Histidine 109-118 serine/threonine/tyrosine interacting like 1 Homo sapiens 60-67 22847929-7 2012 RESULTS: We detected a total of five variants in the ZIC2 gene: a common histidine tract expansion c.716_718dup (p.His239dup), a rare c.1377_1391del_homozygous (p.Ala466_470del, or Ala 15 to 10 contraction), a novel intronic c.1239+18G>A variant, a novel frameshift c.1215dupC (p.Ser406Glnfs*11), and a c.1401_1406dup (p.Ala469_470dup, or alanine tract expansion to 17 residues). Histidine 73-82 Zic family member 2 Homo sapiens 53-57 22822061-8 2012 Prediction of whole hTLR9 ECD-CpG ODN interactions revealed that Arg-337 and Lys-338 directly contact CpG ODN through hydrogen bonding, whereas Lys-347, Arg-348, and His-353 contribute to stabilizing the shape of the ligand binding region. Histidine 166-169 toll like receptor 9 Homo sapiens 20-25 22767596-2 2012 L-histidine decarboxylase (HDC) is the primary enzyme responsible for histamine synthesis and produces histamine from histidine in a one-step reaction. Histidine 2-11 histidine decarboxylase Homo sapiens 27-30 22805477-5 2012 METHODS: Recombinant HMW-glutenin was expressed as histidine-tag protein in E. coli and purified by histidine-tag affinity column. Histidine 51-60 cilia and flagella associated protein 97 Homo sapiens 21-24 22315171-1 2012 BACKGROUND: The relationship between the expression of CD133 and fragile histidine triad (FHIT) or prognosis in Chinese colorectal adenocarcinoma is unknown and needs to be explored. Histidine 73-82 prominin 1 Homo sapiens 55-60 22315171-1 2012 BACKGROUND: The relationship between the expression of CD133 and fragile histidine triad (FHIT) or prognosis in Chinese colorectal adenocarcinoma is unknown and needs to be explored. Histidine 73-82 fragile histidine triad diadenosine triphosphatase Homo sapiens 90-94 22665377-4 2012 An approximately 100-kDa protein was recovered by using recombinant His-tagged SSL3-conjugated Sepharose from the lysate of porcine spleen, and the protein was identified as porcine TLR2 by peptide mass fingerprinting analysis. Histidine 68-71 toll-like receptor 2 Mus musculus 182-186 22621930-7 2012 An analysis of homology models docked with UDP-sugar donors indicates that Asn-391 in UGT3A1 is able to accommodate the N-acetyl group on C2 of UDP-GlcNAc so that the anomeric carbon atom (C1) is optimally situated for catalysis involving His-35. Histidine 239-242 UDP glycosyltransferase family 3 member A1 Homo sapiens 86-92 22240897-3 2012 Here, we repot that golgi-specific Asp-His-His-Cys (DHHC) zinc finger protein (GODZ) regulates TRAIL/DR4-mediated apoptosis. Histidine 39-42 TNF receptor superfamily member 10a Homo sapiens 101-104 21679157-1 2012 Accumulating evidence has demonstrated that FHIT (fragile histidine triad) is a bona fide tumour suppressor gene in a large fraction of human tumours, including hepatocellular cancer. Histidine 58-67 fragile histidine triad diadenosine triphosphatase Homo sapiens 44-48 22389474-7 2012 Purified His(6)-GS and His(6)-GPI proteins bound to type I collagen, and His(6)-GS also bound to laminin, and their level of binding was higher at pH 5.5 than at pH 6.5. Histidine 23-26 glucose-6-phosphate isomerase Lactobacillus crispatus ST1 30-33 22212708-7 2012 The ATP6V1F gene was overexpressed in Escherichia coli indicating that ATP6V1F fusion with the N-terminally His-tagged form gave rise to the accumulation of an expected 17 kDa polypeptide, which was according with the predicted protein and also could be used to purify the protein and study its function. Histidine 108-111 V-type proton ATPase subunit F Ailuropoda melanoleuca 4-11 22077443-8 2012 Furthermore, we found the interaction of LOX-1 with the HNE-histidine adduct to have a dissociation constant of 1.22x10(-8) M using a surface plasmon resonance assay. Histidine 60-69 oxidized low density lipoprotein receptor 1 Homo sapiens 41-46 22020791-6 2012 Moreover, in order to improve production of functional LPI/PEP-19, we modified the protocol normally adopted for preparing histidine tagged-proteins from bacteria, by adding an additional purification step. Histidine 135-144 Purkinje cell protein 4 Rattus norvegicus 71-77 22479576-4 2012 Muscleblind-proteins bind to RNAs via N-terminal zinc fingers of the Cys(3)-His type. Histidine 76-79 muscleblind Drosophila melanogaster 0-11 22139181-2 2011 In this work, two types of recombinant HP0902 protein were crystallized: one with an N-terminal His(6) tag ((H6)HP0902) and the other with a C-terminal His(6) tag (HP0902(H6)). Histidine 96-99 cupin domain-containing protein Helicobacter pylori 26695 39-45 22139181-2 2011 In this work, two types of recombinant HP0902 protein were crystallized: one with an N-terminal His(6) tag ((H6)HP0902) and the other with a C-terminal His(6) tag (HP0902(H6)). Histidine 152-155 cupin domain-containing protein Helicobacter pylori 26695 39-45 22977637-6 2011 The risk of prostate cancer in individuals carrying the SULT1A1(*)2 allele (His(213) allele) was determined by combining the SULT1A1(*)1/SULT1A1(*)2 (Arg/His(213)) and SULT1A1(*)2/SULT1A1(*)2 (His/His(213)) genotypes. Histidine 76-79 sulfotransferase family 1A member 1 Homo sapiens 56-63 22977637-6 2011 The risk of prostate cancer in individuals carrying the SULT1A1(*)2 allele (His(213) allele) was determined by combining the SULT1A1(*)1/SULT1A1(*)2 (Arg/His(213)) and SULT1A1(*)2/SULT1A1(*)2 (His/His(213)) genotypes. Histidine 76-79 sulfotransferase family 1A member 1 Homo sapiens 125-132 22977637-6 2011 The risk of prostate cancer in individuals carrying the SULT1A1(*)2 allele (His(213) allele) was determined by combining the SULT1A1(*)1/SULT1A1(*)2 (Arg/His(213)) and SULT1A1(*)2/SULT1A1(*)2 (His/His(213)) genotypes. Histidine 76-79 sulfotransferase family 1A member 1 Homo sapiens 125-132 22977637-6 2011 The risk of prostate cancer in individuals carrying the SULT1A1(*)2 allele (His(213) allele) was determined by combining the SULT1A1(*)1/SULT1A1(*)2 (Arg/His(213)) and SULT1A1(*)2/SULT1A1(*)2 (His/His(213)) genotypes. Histidine 76-79 sulfotransferase family 1A member 1 Homo sapiens 125-132 22977637-6 2011 The risk of prostate cancer in individuals carrying the SULT1A1(*)2 allele (His(213) allele) was determined by combining the SULT1A1(*)1/SULT1A1(*)2 (Arg/His(213)) and SULT1A1(*)2/SULT1A1(*)2 (His/His(213)) genotypes. Histidine 76-79 sulfotransferase family 1A member 1 Homo sapiens 125-132 22977637-6 2011 The risk of prostate cancer in individuals carrying the SULT1A1(*)2 allele (His(213) allele) was determined by combining the SULT1A1(*)1/SULT1A1(*)2 (Arg/His(213)) and SULT1A1(*)2/SULT1A1(*)2 (His/His(213)) genotypes. Histidine 154-157 sulfotransferase family 1A member 1 Homo sapiens 56-63 21856937-8 2011 Finally, crystal structures of LR (histidine, H134) allele of FcgammaRIIa and FcgammaRIIa-HR reveal two distinct receptor dimers that may represent quaternary states on the cell surface. Histidine 35-44 Fc gamma receptor IIa Homo sapiens 62-73 21856937-8 2011 Finally, crystal structures of LR (histidine, H134) allele of FcgammaRIIa and FcgammaRIIa-HR reveal two distinct receptor dimers that may represent quaternary states on the cell surface. Histidine 35-44 Fc gamma receptor IIa Homo sapiens 78-89 21628446-4 2011 Chromatographic purification and structural analysis by matrix-assisted laser desorption/ionization time-of-flight/time-of-flight (MALDI-TOF/TOF) revealed an Ang II-like octapeptide, angioprotectin, with the sequence Pro-Glu-Val-Tyr-Ile-His-Pro-Phe, which differs from Ang II in Pro1 and Glu2 instead of Asp1 and Arg2. Histidine 237-240 angiogenin Homo sapiens 158-161 21709160-5 2011 We expressed a C-terminally His-tagged form of human HEBP1 in yeast and purified it to homogeneity. Histidine 28-31 heme binding protein 1 Homo sapiens 53-58 21866627-3 2011 pDEST26-His-Cdc42 was transfected by lipofectamine 2000 into SW480 and Colo320 cells with low expression of Cdc42. Histidine 8-11 cell division cycle 42 Homo sapiens 12-17 21866627-3 2011 pDEST26-His-Cdc42 was transfected by lipofectamine 2000 into SW480 and Colo320 cells with low expression of Cdc42. Histidine 8-11 cell division cycle 42 Homo sapiens 108-113 24048792-9 2011 Patients who were heterozygous for the CD32a (Fcgamma receptor IIa) 131 histidine (H) to arginine (R) polymorphism had a significantly decreased PFS (P = .009) after R-bortezomib compared with HH and RR homozygotes. Histidine 72-81 Fc gamma receptor IIa Homo sapiens 39-44 24048792-9 2011 Patients who were heterozygous for the CD32a (Fcgamma receptor IIa) 131 histidine (H) to arginine (R) polymorphism had a significantly decreased PFS (P = .009) after R-bortezomib compared with HH and RR homozygotes. Histidine 72-81 Fc gamma receptor IIa Homo sapiens 46-66 21530495-0 2011 A conserved histidine in human DNLZ/HEP is required for stimulation of HSPA9 ATPase activity. Histidine 12-21 dynein axonemal heavy chain 8 Homo sapiens 77-83 21486062-4 2011 Vibrational bands are assigned by comparison to histidine, phenylalanine, tyrosine, tryptophan, and 3-methylindole model compound data and by isotopic labeling of histidine in the beta2 subunit. Histidine 163-172 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 180-185 21830375-1 2011 BACKGROUND/AIMS: The fragile histidine triad (FHIT) gene is a candidate tumor suppressor gene. Histidine 29-38 fragile histidine triad diadenosine triphosphatase Homo sapiens 46-50 20957682-0 2011 Effect of histidine on autotaxin activity in experimentally induced liver fibrosis. Histidine 10-19 ectonucleotide pyrophosphatase/phosphodiesterase 2 Rattus norvegicus 23-32 20957682-5 2011 Upon treatment with histidine, a significant decrease in liver enzymes, ATX activities, and liver hydroxyproline was observed with a significant increase in plasma TAC in Group IV and a significant decrease in Group V. Histidine as an antioxidant has a protective effect on TAA-induced liver fibrosis; it is beneficial in rats not only by inhibition of collagen synthesis and increasing TAC but also by inhibition of ATX activities thus reducing its capacity to produce lysophosphatidic acid, which has a role in liver fibrosis. Histidine 20-29 ectonucleotide pyrophosphatase/phosphodiesterase 2 Rattus norvegicus 72-75 20957682-5 2011 Upon treatment with histidine, a significant decrease in liver enzymes, ATX activities, and liver hydroxyproline was observed with a significant increase in plasma TAC in Group IV and a significant decrease in Group V. Histidine as an antioxidant has a protective effect on TAA-induced liver fibrosis; it is beneficial in rats not only by inhibition of collagen synthesis and increasing TAC but also by inhibition of ATX activities thus reducing its capacity to produce lysophosphatidic acid, which has a role in liver fibrosis. Histidine 20-29 ectonucleotide pyrophosphatase/phosphodiesterase 2 Rattus norvegicus 417-420 21243331-4 2011 Comparisons of the sequences for lipoxygenase 1 (Lx1) and lipoxygenase 2 (Lx2) genes in the mutant (OX948) with those in a line with normal lipoxygenase levels (RG10) showed that the mutations in these genes affected a highly conserved group of six histidines necessary for enzymatic activity. Histidine 249-259 seed linoleate 9S-lipoxygenase-2 Glycine max 58-72 21243331-6 2011 A single T-A substitution in Lx2 changes histidine H532 (one of the iron-binding ligands essential for L-2 activity) to glutamine. Histidine 41-50 seed linoleate 9S-lipoxygenase-2 Glycine max 29-32 21243331-6 2011 A single T-A substitution in Lx2 changes histidine H532 (one of the iron-binding ligands essential for L-2 activity) to glutamine. Histidine 41-50 seed linoleate 9S-lipoxygenase-2 Glycine max 103-106 21343298-8 2011 The E-loop of Nox4 but not Nox1 and Nox2 contains a highly conserved histidine that could serve as a source for protons to accelerate spontaneous dismutation of superoxide to form H(2)O(2). Histidine 69-78 NADPH oxidase 4 Homo sapiens 14-18 21343298-9 2011 Mutation of this but not of four other conserved histidines also switched Nox4 from H(2)O(2) to O(2)( -) formation. Histidine 49-59 NADPH oxidase 4 Homo sapiens 74-78 21250662-0 2011 Alteration of hydrogen bonding in the vicinity of histidine 48 disrupts millisecond motions in RNase A. Histidine 50-59 ribonuclease A family member 1, pancreatic Homo sapiens 95-102 21268659-0 2011 Histidines in the octapeptide repeat of PrPC react with PrPSc at an acidic pH. Histidine 0-10 prion protein Mus musculus 40-44 21268659-0 2011 Histidines in the octapeptide repeat of PrPC react with PrPSc at an acidic pH. Histidine 0-10 prion protein Mus musculus 56-61 21268659-8 2011 However, modified PrP containing histidine to alanine substitutions within the octapeptide repeats was still converted to PrP(Sc) in N2a cells. Histidine 33-42 prion protein Mus musculus 18-21 21268659-8 2011 However, modified PrP containing histidine to alanine substitutions within the octapeptide repeats was still converted to PrP(Sc) in N2a cells. Histidine 33-42 prion protein Mus musculus 122-125 21168482-9 2011 Co-expression of secretory forms of TNSALP (W) and TNSALP (A116T), which are engineered to replace the C-terminal GPI anchor with a tag sequence (his-tag or flag-tag), resulted in the release of heteromeric complexes consisting of TNSALP (W)-his and TNSALP (A116T)-flag. Histidine 146-149 alkaline phosphatase, biomineralization associated Homo sapiens 36-42 21168482-9 2011 Co-expression of secretory forms of TNSALP (W) and TNSALP (A116T), which are engineered to replace the C-terminal GPI anchor with a tag sequence (his-tag or flag-tag), resulted in the release of heteromeric complexes consisting of TNSALP (W)-his and TNSALP (A116T)-flag. Histidine 146-149 alkaline phosphatase, biomineralization associated Homo sapiens 51-57 21168482-9 2011 Co-expression of secretory forms of TNSALP (W) and TNSALP (A116T), which are engineered to replace the C-terminal GPI anchor with a tag sequence (his-tag or flag-tag), resulted in the release of heteromeric complexes consisting of TNSALP (W)-his and TNSALP (A116T)-flag. Histidine 146-149 alkaline phosphatase, biomineralization associated Homo sapiens 51-57 21168482-9 2011 Co-expression of secretory forms of TNSALP (W) and TNSALP (A116T), which are engineered to replace the C-terminal GPI anchor with a tag sequence (his-tag or flag-tag), resulted in the release of heteromeric complexes consisting of TNSALP (W)-his and TNSALP (A116T)-flag. Histidine 146-149 alkaline phosphatase, biomineralization associated Homo sapiens 51-57 21168482-9 2011 Co-expression of secretory forms of TNSALP (W) and TNSALP (A116T), which are engineered to replace the C-terminal GPI anchor with a tag sequence (his-tag or flag-tag), resulted in the release of heteromeric complexes consisting of TNSALP (W)-his and TNSALP (A116T)-flag. Histidine 242-245 alkaline phosphatase, biomineralization associated Homo sapiens 36-42 21168482-9 2011 Co-expression of secretory forms of TNSALP (W) and TNSALP (A116T), which are engineered to replace the C-terminal GPI anchor with a tag sequence (his-tag or flag-tag), resulted in the release of heteromeric complexes consisting of TNSALP (W)-his and TNSALP (A116T)-flag. Histidine 242-245 alkaline phosphatase, biomineralization associated Homo sapiens 51-57 21168482-9 2011 Co-expression of secretory forms of TNSALP (W) and TNSALP (A116T), which are engineered to replace the C-terminal GPI anchor with a tag sequence (his-tag or flag-tag), resulted in the release of heteromeric complexes consisting of TNSALP (W)-his and TNSALP (A116T)-flag. Histidine 242-245 alkaline phosphatase, biomineralization associated Homo sapiens 51-57 21168482-9 2011 Co-expression of secretory forms of TNSALP (W) and TNSALP (A116T), which are engineered to replace the C-terminal GPI anchor with a tag sequence (his-tag or flag-tag), resulted in the release of heteromeric complexes consisting of TNSALP (W)-his and TNSALP (A116T)-flag. Histidine 242-245 alkaline phosphatase, biomineralization associated Homo sapiens 51-57 21121676-0 2011 Mass spectrometry detection of histidine phosphorylation on NM23-H1. Histidine 31-40 NME/NM23 nucleoside diphosphate kinase 1 Homo sapiens 60-67 21121676-3 2011 Here, we present a novel buffer system to show histidine phosphorylation of NM23-H1, the product of the first identified putative human metastasis suppressor gene (NME1), which catalyzes the transfer of the gamma-phosphate from nucleoside triphosphates to nucleoside diphosphates. Histidine 47-56 NME/NM23 nucleoside diphosphate kinase 1 Homo sapiens 76-83 21121676-3 2011 Here, we present a novel buffer system to show histidine phosphorylation of NM23-H1, the product of the first identified putative human metastasis suppressor gene (NME1), which catalyzes the transfer of the gamma-phosphate from nucleoside triphosphates to nucleoside diphosphates. Histidine 47-56 NME/NM23 nucleoside diphosphate kinase 1 Homo sapiens 164-168 21870644-2 2011 The present study aimed to identify and analyze the role of homozygous deletion (HZD) and transcriptional alterations of fragile histidine triad (FHIT) gene in the development and progression of bilharzial bladder cancer in Egyptian patients. Histidine 129-138 fragile histidine triad diadenosine triphosphatase Homo sapiens 146-150 21743838-1 2011 The Fragile Histidine Triad gene or FHIT functions as tumor suppressor in many epithelial cell types. Histidine 12-21 fragile histidine triad diadenosine triphosphatase Homo sapiens 36-40 22146730-2 2011 The putative processing enzyme, dipeptidyl peptidase IV, was expressed as a glycosylated His-tag fusion protein (rDPP-IV) via the baculovirus expression system. Histidine 89-92 dipeptidylpeptidase 4 Rattus norvegicus 113-120 21941573-8 2011 Binding of a D5-derived peptide, HKH20 (His(479)-His(498)), to the fungal cell membrane was visualized by fluorescence microscopy. Histidine 40-43 defensin alpha 24 Rattus norvegicus 13-15 21941573-8 2011 Binding of a D5-derived peptide, HKH20 (His(479)-His(498)), to the fungal cell membrane was visualized by fluorescence microscopy. Histidine 49-52 defensin alpha 24 Rattus norvegicus 13-15 21058400-2 2011 Ngb can reversibly bind small ligands such as O2 and CO to the heme iron by replacing the distal histidine which is bound to the iron as the endogenous ligand. Histidine 97-106 neuroglobin Mus musculus 0-3 21208569-3 2011 The BALB/c mice were immuned with purified protein His-PCGF1-128/189 as antigen. Histidine 51-54 polycomb group ring finger 1 Mus musculus 55-60 21090702-9 2010 The protonation state of two histidines (His559 and His516) at the catalytic site of this flavoprotein is found to have a remarkable influence on the isotropic hyperfine coupling of one of the methyl groups on the neutral FAD radical, which is consistent with experimental findings in other flavoproteins (J. Biol. Histidine 29-39 Suppressor of variegation 3-3 Drosophila melanogaster 90-102 20884616-3 2010 We previously showed that NDPK-B activates the K(+) channel KCa3.1 via histidine phosphorylation of the C terminus of KCa3.1, which is required for T cell receptor-stimulated Ca(2+) flux and proliferation of activated naive human CD4 T cells. Histidine 71-80 potassium calcium-activated channel subfamily N member 4 Homo sapiens 60-66 20884616-3 2010 We previously showed that NDPK-B activates the K(+) channel KCa3.1 via histidine phosphorylation of the C terminus of KCa3.1, which is required for T cell receptor-stimulated Ca(2+) flux and proliferation of activated naive human CD4 T cells. Histidine 71-80 potassium calcium-activated channel subfamily N member 4 Homo sapiens 118-124 21041096-4 2010 The preferential hydrogen bonding network formation between His-12 and His-119 of RNase A with the polar carboxylic and amino groups of these compounds has been evidenced from the docking studies. Histidine 60-63 ribonuclease A family member 1, pancreatic Homo sapiens 82-89 21041096-4 2010 The preferential hydrogen bonding network formation between His-12 and His-119 of RNase A with the polar carboxylic and amino groups of these compounds has been evidenced from the docking studies. Histidine 71-74 ribonuclease A family member 1, pancreatic Homo sapiens 82-89 20718765-9 2010 RESULTS: PAX8 gene sequencing revealed a heterozygous mutation that consists of the substitution of a histidine residue with a glutamine at position 55 of the PAX8 protein (H55Q). Histidine 102-111 paired box 8 Homo sapiens 9-13 20718765-9 2010 RESULTS: PAX8 gene sequencing revealed a heterozygous mutation that consists of the substitution of a histidine residue with a glutamine at position 55 of the PAX8 protein (H55Q). Histidine 102-111 paired box 8 Homo sapiens 159-163 20952122-3 2010 Recently, the ferrous derivative of Alcaligenes xylosoxidans cytochrome c" (Axcyt c") and of cardiolipin-bound horse heart cytochrome c (CL-hhcyt c) have been reported to bind NO to the "dark side" of the heme (i.e., as the proximal axial ligand) replacing the endogenous ligand His. Histidine 279-282 D-alanyl-D-alanine carboxypeptidase Achromobacter xylosoxidans 61-73 20952122-3 2010 Recently, the ferrous derivative of Alcaligenes xylosoxidans cytochrome c" (Axcyt c") and of cardiolipin-bound horse heart cytochrome c (CL-hhcyt c) have been reported to bind NO to the "dark side" of the heme (i.e., as the proximal axial ligand) replacing the endogenous ligand His. Histidine 279-282 D-alanyl-D-alanine carboxypeptidase Achromobacter xylosoxidans 123-135 20812745-5 2010 We report that when a single amino acid within the MoFe protein (beta-98(Tyr)) is substituted by His, the resulting MoFe protein supports catalytic reduction of the nitrogenous substrate hydrazine (N(2)H(4)) to two ammonia molecules when provided with a low potential reductant, polyaminocarboxylate ligated Eu(II) (E(m) -1.1 V vs NHE). Histidine 97-100 solute carrier family 9 member C1 Homo sapiens 331-334 20628046-0 2010 The identification of Histidine 712 as a critical residue for constitutive TRPV5 internalization. Histidine 22-31 transient receptor potential cation channel, subfamily V, member 5 Mus musculus 75-80 20628046-5 2010 Removal of amino acid His(712) elevated the [Ca(2+)](i), indicating enlarged TRPV5 activity. Histidine 22-25 transient receptor potential cation channel, subfamily V, member 5 Mus musculus 77-82 20628046-6 2010 In addition, substitution of the positively charged His(712) for a negative (H712D) or neutral (H712N) amino acid also stimulated TRPV5 activity. Histidine 52-55 transient receptor potential cation channel, subfamily V, member 5 Mus musculus 130-135 20628046-7 2010 This critical role of His(712) was confirmed by patch clamp analysis, which demonstrates increased Na(+) and Ca(2+) currents for TRPV5-H712D. Histidine 22-25 transient receptor potential cation channel, subfamily V, member 5 Mus musculus 129-134 20628046-11 2010 Together, these results demonstrate that His(712) plays an essential role in plasma membrane regulation of TRPV5 via a constitutive endocytotic mechanism. Histidine 41-44 transient receptor potential cation channel, subfamily V, member 5 Mus musculus 107-112 20674369-5 2010 The pentagalactosylated dendrimer J4 betaGal(4)(Lys-Arg-His-Leu)(2)Dap-Thr-Tyr-His-Lys(betaGal)-Cys) selectively labels Jurkat cell as the fluorescein derivative J4F, but its colchicine conjugate J4C lacks cytotoxicity. Histidine 56-59 death associated protein Homo sapiens 67-70 20799012-8 2010 These results suggest that Tyr/His(1) and Ile/Thr(7) of GIP/GLP-1 peptides confer differential ligand selectivity toward GIPR and GLP1R. Histidine 31-34 glucagon like peptide 1 receptor Homo sapiens 130-135 20689140-0 2010 Homozygous deletion but not mutation of exons 5 and 8 of the fragile histidine triad (FHIT) gene is associated with features of differentiated thyroid carcinoma. Histidine 69-78 fragile histidine triad diadenosine triphosphatase Homo sapiens 86-90 20689140-1 2010 The fragile histidine triad (FHIT) gene encompasses the most common human fragile site, FRA3B at 3p14.2, a region that is involved in homozygous deletions in a variety of human tumors. Histidine 12-21 fragile histidine triad diadenosine triphosphatase Homo sapiens 29-33 20689140-1 2010 The fragile histidine triad (FHIT) gene encompasses the most common human fragile site, FRA3B at 3p14.2, a region that is involved in homozygous deletions in a variety of human tumors. Histidine 12-21 fragile histidine triad diadenosine triphosphatase Homo sapiens 88-93 19965803-5 2010 The presence of an arginine instead of a histidine residue at amino acid position 131 (H131R) in the extracellular domain of FcgammaRIIa reduces the affinity of the receptor for IgG(2) and IgG(3) isotypes but increases the binding activity for C reactive protein (CRP). Histidine 41-50 Fc gamma receptor IIa Homo sapiens 125-136 20411530-4 2010 Dpl is able to bind at least one copper ion, and the specific metal-binding site has been identified as the histidine residue at the beginning of the third helical region. Histidine 108-117 prion like protein doppel Homo sapiens 0-3 19768521-4 2010 Thus we analyzed the D-amino acid contents of His-tag-purified beta-galactosidase and human urocortin, which were synthesized by Escherichia coli grown in controlled synthetic media. Histidine 46-49 galactosidase beta 1 Homo sapiens 63-81 20164530-4 2010 X-ray diffraction (1.9 A) revealed a GLTP fold with all key sugar headgroup recognition residues (Asp(66), Asn(70), Lys(73), Trp(109), and His(147)) conserved and properly oriented for glycolipid binding. Histidine 139-142 glycolipid transfer protein Homo sapiens 37-41 20180778-3 2010 The nucleophilic cysteine residue and the adjacent histidine residue, which are conserved in all active dual-specificity phosphatases, are replaced by serine and phenylalanine residues respectively in MK-STYX. Histidine 51-60 serine/threonine/tyrosine interacting like 1 Homo sapiens 201-208 20180778-4 2010 Mutations to introduce histidine and cysteine residues into the active site of MK-STYX generated an active phosphatase. Histidine 23-32 serine/threonine/tyrosine interacting like 1 Homo sapiens 79-86 20226173-6 2010 Results showed that TOP His(600) residue makes important interactions with the substrate, supporting the prediction that His(600) moves toward the substrate due to a hinge movement similar to the Dcp and ACE-2. Histidine 24-27 angiotensin converting enzyme 2 Homo sapiens 204-209 20226173-6 2010 Results showed that TOP His(600) residue makes important interactions with the substrate, supporting the prediction that His(600) moves toward the substrate due to a hinge movement similar to the Dcp and ACE-2. Histidine 121-124 angiotensin converting enzyme 2 Homo sapiens 204-209 20167204-6 2010 These results collectively suggest that the third C(3)H zinc finger, Cys-His motif and C(3)HC(4) RING zinc finger are indispensable for the anti-neurogenic activity of mkrn2. Histidine 73-76 E3 ubiquitin-protein ligase makorin-2 Xenopus laevis 168-173 20158486-4 2010 D-Lys6-GnRH and [Asn1-Val5]-angiotensin II were modified at their histidine side chain within the peptide, whilst IGF-1 (1-3) was modified at the C-terminal glutamic acid residue. Histidine 66-75 gonadotropin releasing hormone 1 Homo sapiens 7-11 19730990-3 2010 Fragile Histidine Triad (FHIT) has been shown to play a pivotal role in carcinogenesis. Histidine 8-17 fragile histidine triad diadenosine triphosphatase Homo sapiens 25-29 19876776-4 2010 Recombinant histidine-tagged S. xylosus lipase was purified by affinity chromatography in an HPLC system. Histidine 12-21 YSIRK-type signal peptide-containing protein Staphylococcus xylosus 40-46 21222265-3 2010 alpha-Melanocyte stimulating hormone is a tridecapeptide, with the core sequence His(6)-Phe(7)-Arg(8)-Trp(9) shared with beta- and gamma-MSH and identified as essential for receptor activation and stimulation of pigmentation. Histidine 81-84 pro-opiomelanocortin-alpha Mus musculus 0-36 20108989-5 2010 Peginterferon-alpha-2b has a linear 12 kDa PEG chain covalently attached primarily to histidine-34 of interferon-alpha-2b via an unstable urethane bond that is subject to hydrolysis once injected, releasing native interferon-alpha-2b. Histidine 86-95 interferon alpha 2 Homo sapiens 3-22 20108989-5 2010 Peginterferon-alpha-2b has a linear 12 kDa PEG chain covalently attached primarily to histidine-34 of interferon-alpha-2b via an unstable urethane bond that is subject to hydrolysis once injected, releasing native interferon-alpha-2b. Histidine 86-95 interferon alpha 2 Homo sapiens 102-121 20946858-5 2010 In addition, experimental protocols for studying the consequences of heterotrimeric G protein activation via NDPK/Gbetagamma mediated phosphorelay, the regulation of ACL activity and of KCa3.1 conductivity by histidine phosphorylation will be presented. Histidine 209-218 potassium calcium-activated channel subfamily N member 4 Homo sapiens 186-192 20061554-4 2010 The interactions between DDB1 and COP1, SPA1, and SPA3 were disrupted by mutations in the WDXR motifs of MBP-COP1, His-SPA1, and His-SPA3. Histidine 115-118 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 34-38 20061554-4 2010 The interactions between DDB1 and COP1, SPA1, and SPA3 were disrupted by mutations in the WDXR motifs of MBP-COP1, His-SPA1, and His-SPA3. Histidine 115-118 SPA (suppressor of phyA-105) protein family Arabidopsis thaliana 40-44 20061554-4 2010 The interactions between DDB1 and COP1, SPA1, and SPA3 were disrupted by mutations in the WDXR motifs of MBP-COP1, His-SPA1, and His-SPA3. Histidine 115-118 SPA (suppressor of phyA-105) protein family Arabidopsis thaliana 119-123 20061554-4 2010 The interactions between DDB1 and COP1, SPA1, and SPA3 were disrupted by mutations in the WDXR motifs of MBP-COP1, His-SPA1, and His-SPA3. Histidine 129-132 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 34-38 20061554-4 2010 The interactions between DDB1 and COP1, SPA1, and SPA3 were disrupted by mutations in the WDXR motifs of MBP-COP1, His-SPA1, and His-SPA3. Histidine 129-132 SPA (suppressor of phyA-105) protein family Arabidopsis thaliana 40-44 19834685-4 2009 [Arg(A0)]-HI induced a marked increase in the phosphotyrosine content of endosomal insulin receptor, coinciding with a more sustained endosomal association of growth factor receptor-bound protein 14 (GRB14), and a higher and prolonged activation of mitogen-activated protein kinase pathways. Histidine 9-12 insulin receptor Homo sapiens 83-99 19834685-9 2009 The endosomal conversion of [Arg(A0)]-HI into human insulin might extend the insulin receptor signalling at this locus. Histidine 37-40 insulin receptor Homo sapiens 77-93 19771477-3 2009 Squirrel RNase 1 genes encode typical RNase A ribonucleases, each with eight cysteines, a conserved CKXXNTF signature motif, and a canonical His(12)-Lys(41)-His(119) catalytic triad. Histidine 141-144 ribonuclease A family member 1, pancreatic Homo sapiens 9-16 19771477-3 2009 Squirrel RNase 1 genes encode typical RNase A ribonucleases, each with eight cysteines, a conserved CKXXNTF signature motif, and a canonical His(12)-Lys(41)-His(119) catalytic triad. Histidine 157-160 ribonuclease A family member 1, pancreatic Homo sapiens 9-16 19751438-1 2009 BACKGROUND: The expression of a fragile histidine triad (FHIT) protein is lost in stomach tumors. Histidine 40-49 fragile histidine triad diadenosine triphosphatase Homo sapiens 57-61 19487247-1 2009 An N-terminal domain histidine [corresponding to position 39 of UDP-glucuronosyltransferase (UGT) 1A1] is conserved in all UGT1A and UGT2B subfamily proteins except UGT1A4 (Pro-40) and UGT2B10 (Leu-34). Histidine 21-30 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 123-128 19487247-5 2009 The conserved N-terminal domain histidine of UGT1A1, UGT1A6, UGT1A9, and UGT2B7 was mutated to proline and leucine 34 of UGT2B10 was substituted with histidine, and the capacity of the wild-type and mutant proteins to glucuronidate 4MU, 1NP, LTG, TFP, and naproxen was characterized. Histidine 32-41 UDP glucuronosyltransferase family 1 member A6 Homo sapiens 53-59 19487247-5 2009 The conserved N-terminal domain histidine of UGT1A1, UGT1A6, UGT1A9, and UGT2B7 was mutated to proline and leucine 34 of UGT2B10 was substituted with histidine, and the capacity of the wild-type and mutant proteins to glucuronidate 4MU, 1NP, LTG, TFP, and naproxen was characterized. Histidine 32-41 UDP glucuronosyltransferase family 1 member A9 Homo sapiens 61-67 19487247-5 2009 The conserved N-terminal domain histidine of UGT1A1, UGT1A6, UGT1A9, and UGT2B7 was mutated to proline and leucine 34 of UGT2B10 was substituted with histidine, and the capacity of the wild-type and mutant proteins to glucuronidate 4MU, 1NP, LTG, TFP, and naproxen was characterized. Histidine 150-159 UDP glucuronosyltransferase family 1 member A6 Homo sapiens 53-59 19487247-5 2009 The conserved N-terminal domain histidine of UGT1A1, UGT1A6, UGT1A9, and UGT2B7 was mutated to proline and leucine 34 of UGT2B10 was substituted with histidine, and the capacity of the wild-type and mutant proteins to glucuronidate 4MU, 1NP, LTG, TFP, and naproxen was characterized. Histidine 150-159 UDP glucuronosyltransferase family 1 member A9 Homo sapiens 61-67 19479888-1 2009 The fragile histidine triad gene (human FHIT, mouse Fhit) has been shown to act as a tumor suppressor gene. Histidine 12-21 fragile histidine triad diadenosine triphosphatase Homo sapiens 40-44 19728931-6 2009 In this study, mouse FADD (80-205) containing DD domain and C-terminal region, designated as C-FADD, was expressed in E. coli with His-tag at the N-terminus and purified by Ni2+ affinity chromatography. Histidine 131-134 steroid sulfatase Mus musculus 90-94 19418484-1 2009 Fragile histidine triad (FHIT) is a tumor suppressor gene whose allelic loss is associated to a number of human cancers. Histidine 8-17 fragile histidine triad diadenosine triphosphatase Homo sapiens 25-29 18756395-3 2008 In most histamine-containing foods the majority of the histamine is generated by decarboxylation of the histidine through histidine decarboxylase enzymes derived from the bacteria present in food. Histidine 104-113 histidine decarboxylase Homo sapiens 122-145 18460012-1 2008 Diphthamide is a post-translational derivative of histidine in protein synthesis elongation factor-2 (eEF-2) that is present in all eukaryotes with no known normal physiological role. Histidine 50-59 elongation factor 2 Cricetulus griseus 102-107 18482847-4 2008 The assembled fragment was introduced into P. pastoris expression vector pPIC9K and the resultant plasmid pPIC9K-zbtb7a-his(6) was transformed into the P. pastoris strain GS115 by electroporation. Histidine 120-123 zinc finger and BTB domain containing 7A Homo sapiens 113-119 18474604-7 2008 A single amino acid substitution of Asp at residue position 218 of TRAIL to His or Tyr was predicted to have a favorable effect on DR4 binding specificity. Histidine 76-79 TNF receptor superfamily member 10a Homo sapiens 131-134 18445588-4 2008 His --> Glu/Asp mutations of the active site histidines designed to mimic the phosphorylated states reveal binding equilibria that favor phosphoryl transfer from EIN to HPr. Histidine 0-3 haptoglobin-related protein Homo sapiens 172-175 18445588-4 2008 His --> Glu/Asp mutations of the active site histidines designed to mimic the phosphorylated states reveal binding equilibria that favor phosphoryl transfer from EIN to HPr. Histidine 48-58 haptoglobin-related protein Homo sapiens 172-175 18450746-5 2008 In the present study we demonstrate that His-119/His-120 and Cys-409 are the axial ligands for the Fe(III)-protoporphyrin IX complex (hemin) in HRI, based on spectral data on site-directed mutant proteins. Histidine 41-44 eukaryotic translation initiation factor 2 alpha kinase 1 Homo sapiens 144-147 18450746-5 2008 In the present study we demonstrate that His-119/His-120 and Cys-409 are the axial ligands for the Fe(III)-protoporphyrin IX complex (hemin) in HRI, based on spectral data on site-directed mutant proteins. Histidine 49-52 eukaryotic translation initiation factor 2 alpha kinase 1 Homo sapiens 144-147 18467526-7 2008 The different residues in GnRH II (His(5), Trp(7), Tyr(8)) were introduced singly or in pairs into GnRH I. Tyr(5) replacement by His(5) produced the highest increase in the antiproliferative potency of GnRH I. Tyr(8) substitution of Arg(8) produced the most selective analog, with very poor inositol phosphate generation but high antiproliferative potency. Histidine 35-38 gonadotropin releasing hormone 2 Homo sapiens 26-33 18491920-6 2008 The tail histidine residues, along with two previously identified lysine residues, account for a major part of the polyelectrolyte contribution to binding and for the nonspecific affinity of Mbp1 for DNA. Histidine 9-18 transcription factor MBP1 Saccharomyces cerevisiae S288C 191-195 18384742-2 2008 Fluorescence polarization studies presented here demonstrate a specific interaction of ETR1 with the histidine-containing transfer protein AHP1, supporting the idea that a phosphorelay module is involved in ethylene signaling. Histidine 101-110 CUGBP Elav-like family member 3 Homo sapiens 87-91 17912498-8 2008 Our results revealed that urinary 8-OHdG level was higher in chewers with SULT1A1 Arg-His genotype than in chewers with SULT1A1 Arg-Arg genotype. Histidine 86-89 sulfotransferase family 1A member 1 Homo sapiens 74-81 18561331-10 2008 Among the radical scavengers, histidine significantly inhibited the cytotoxic activity of H2-a, suggesting the involvement of singlet oxygen in the cytotoxicity. Histidine 30-39 H2A clustered histone 18 Homo sapiens 90-94 18221322-1 2008 BACKGROUND: The purpose of this study was to determine fragile histidine triad (FHIT) and p53 protein expression, and to analyze FHIT and p53 gene status in keratocystic odontogenic tumor (KOT), dentigerous cysts (DC) and radicular cysts (RC). Histidine 63-72 fragile histidine triad diadenosine triphosphatase Homo sapiens 80-84 21479430-3 2008 We investigated whether this 10-residue histidine tract polymorphism of the ZIC2 gene (c.718_720dupCAC) was associated with the risk of NTDs in a sample of 138 patients and their parents from the Latin American Collaborative Study of Congenital Malformations (ECLAMC) hospital network. Histidine 40-49 Zic family member 2 Homo sapiens 76-80 18227067-4 2008 Mutation of the S4 arginine closest to the cytosolic side of KCa3.1 to histidine resulted in expression at the cell surface. Histidine 71-80 potassium calcium-activated channel subfamily N member 4 Homo sapiens 61-67 18021260-5 2008 Replacement of a single residue (His-->Ala) in the catalytic center reduced the activity of HDACs 1 and 2 by 80%, and abolished HDAC3 activity; the mutant HDACs were expressed at similar levels and in the same multiprotein complexes as wild-type HDACs. Histidine 33-36 histone deacetylase 3 Homo sapiens 131-136 18357366-1 2008 The fragile histidine triad (FHIT), frequently lost in many cancers, was identified as a candidate tumor suppressor gene at chromosome 3p locus 14.2. Histidine 12-21 fragile histidine triad diadenosine triphosphatase Homo sapiens 29-33 18178100-2 2008 In this study, a new mouse recombinant ACBP was produced by insertion of a histidine (his) tag at the C-terminus to allow efficient purification by Ni-affinity chromatography. Histidine 75-84 diazepam binding inhibitor Mus musculus 39-43 18178100-2 2008 In this study, a new mouse recombinant ACBP was produced by insertion of a histidine (his) tag at the C-terminus to allow efficient purification by Ni-affinity chromatography. Histidine 4-7 diazepam binding inhibitor Mus musculus 39-43 18178100-5 2008 His-ACBP bound the naturally occurring fluorescent cis-parinaroyl-CoA with very high affinity (K(d)=2.15 nM), but exhibited no affinity for non-esterified cis-parinaric acid. Histidine 0-3 diazepam binding inhibitor Mus musculus 4-8 18178100-6 2008 To determine if the presence of the C-terminal his-tag altered ACBP interactions with other proteins, direct binding to hepatocyte nuclear factor-4alpha (HNF-4alpha), a nuclear receptor regulating transcription of genes involved in lipid metabolism, was examined. Histidine 47-50 diazepam binding inhibitor Mus musculus 63-67 18243046-5 2008 Furthermore, the status of the fragile histidine triad gene (FHIT) in chromosome band 3p14.2 was studied by fluorescence in situ hybridization (FISH) in epithelial cells that had been cultured after removal of bleomycin. Histidine 39-48 fragile histidine triad diadenosine triphosphatase Homo sapiens 61-65 17965005-3 2008 PCC6803 in which the axial ligand, D1-His198, of special pair chlorophyll PD1 was replaced with Gln and where D1-Thr179, which overlies monomeric chlorophyll ChlD1, was replaced with His. Histidine 38-41 programmed cell death 1 Homo sapiens 74-77 18052938-3 2008 The present results show that in HepG2 human hepatoma cells, the total amount of C/EBPbeta protein, both the activating [LAP* and LAP (liver-enriched activating protein)] and inhibitory [LIP (liver-enriched inhibitory)] isoforms, was increased in histidine-deprived cells. Histidine 247-256 CCAAT enhancer binding protein beta Homo sapiens 81-90 18646716-1 2008 OBJECTIVE: To investigate the expression of nuclear factor-kappa-B (NF-KB)/P65 and fragile histidine triad (FHIT) in colorectal carcinoma and clinical significance thereof. Histidine 91-100 fragile histidine triad diadenosine triphosphatase Homo sapiens 108-112 18179643-2 2008 Two allelic dimorphisms of these receptors, valine/phenylalanine-158 of CD16A and histidine/arginine-131 of CD32A, modulate their affinity for certain human IgG subclasses. Histidine 82-91 Fc gamma receptor IIa Homo sapiens 108-113 18197705-5 2008 In this study the two T3 Cu coordinating His residues which lie in this pathway in Fet3 have been mutated, H483Q, H483C, H485Q, and H485C, to study how perturbation at the TNC impacts the T1 Cu site. Histidine 41-44 ferroxidase FET3 Saccharomyces cerevisiae S288C 83-87 17990982-8 2008 TRAC-1 and its relatives were found to contain, apart from the RING domain, a C2HC (Cys(2)-His-Cys)- and two C2H2 (Cys(2)-His(2))-type zinc fingers, as well as a UIM (ubiquitin-interacting motif). Histidine 91-94 ring finger protein 125 Homo sapiens 0-6 18202004-3 2008 CCM1 has two putative zinc-binding domains with several conserved cysteine and histidine residues in its N-terminal region. Histidine 79-88 uncharacterized protein Chlamydomonas reinhardtii 0-4 18069127-5 2008 Competition experiments showed [3-Me-His(2)]TRH potently displaced [(3)H][3-Me-His(2)]TRH binding from all tissues/cells investigated. Histidine 37-40 thyrotropin releasing hormone Rattus norvegicus 44-47 18069127-5 2008 Competition experiments showed [3-Me-His(2)]TRH potently displaced [(3)H][3-Me-His(2)]TRH binding from all tissues/cells investigated. Histidine 37-40 thyrotropin releasing hormone Rattus norvegicus 86-89 18069127-5 2008 Competition experiments showed [3-Me-His(2)]TRH potently displaced [(3)H][3-Me-His(2)]TRH binding from all tissues/cells investigated. Histidine 79-82 thyrotropin releasing hormone Rattus norvegicus 44-47 18069127-5 2008 Competition experiments showed [3-Me-His(2)]TRH potently displaced [(3)H][3-Me-His(2)]TRH binding from all tissues/cells investigated. Histidine 79-82 thyrotropin releasing hormone Rattus norvegicus 86-89 17468165-5 2007 Oxygen, nitric oxide, or carbon monoxide can displace the distal histidine which, in ferrous Ngb as well as in ferric Ngb, is bound to the iron, yielding a reversible adduct. Histidine 65-74 neuroglobin Mus musculus 93-96 17468165-5 2007 Oxygen, nitric oxide, or carbon monoxide can displace the distal histidine which, in ferrous Ngb as well as in ferric Ngb, is bound to the iron, yielding a reversible adduct. Histidine 65-74 neuroglobin Mus musculus 118-121 17468165-7 2007 We report the results of extended (90 ns) molecular dynamics simulations in water of ferrous deoxy and carboxy murine neuroglobin, which are both coordinated on the distal site, in the latter case by CO and in the former one by the distal His(64)(E7). Histidine 239-242 neuroglobin Mus musculus 118-129 17438030-3 2007 To investigate the LcrV-TLR2 interaction in vitro, His-tagged recombinant LcrV (rLcrV) from Yersinia pestis was cloned and expressed in Escherichia coli and purified through Ni-nitrilotriacetic acid column chromatography. Histidine 51-54 toll-like receptor 2 Mus musculus 24-28 17660358-2 2007 Through expression of profluorescent, photoinsensitive Tyr-to-His mutant alleles of Arabidopsis thaliana phytochrome B (PHYB(Y276H)) and Arabidopsis phytochrome A (PHYA(Y242H)) in transgenic Arabidopsis plants, we demonstrate that photoconversion is not a prerequisite for phytochrome signaling. Histidine 62-65 phytochrome B Arabidopsis thaliana 120-124 17548701-1 2007 Many studies have established that loss of heterozygosity and/or altered expression of the fragile histidine triad (FHIT) gene is a common event in a number of tumor types including prostate carcinoma. Histidine 99-108 fragile histidine triad diadenosine triphosphatase Homo sapiens 116-120 17482720-1 2007 Recently we have demonstrated that replacing His(6) by constrained amino acids(2) in the well-known antagonist SHU-9119 resulted in potent and selective antagonist ligands especially at the hMC3R and hMC5 receptors. Histidine 45-48 melanocortin 3 receptor Homo sapiens 190-195 17470807-7 2007 The model identifies key ionic and hydrophobic interactions at the binding interface, including hydrogen-bonding between His-87 of actin to Ser-89 of cofilin that may control the charge dependence of cofilin binding. Histidine 121-124 cofilin 1 Homo sapiens 150-157 17470807-7 2007 The model identifies key ionic and hydrophobic interactions at the binding interface, including hydrogen-bonding between His-87 of actin to Ser-89 of cofilin that may control the charge dependence of cofilin binding. Histidine 121-124 cofilin 1 Homo sapiens 200-207 17470809-0 2007 A histidine residue acting as a controlling site for dioxygen reduction and proton pumping by cytochrome c oxidase. Histidine 2-11 cytochrome c oxidase subunit 6A1, mitochondrial Bos taurus 94-114 17470809-3 2007 Here, we report a coupling mechanism by a histidine (His-503) at the entrance of a proton transfer pathway to the dioxygen reduction site (D-pathway) of bovine heart cytochrome c oxidase. Histidine 42-51 cytochrome c oxidase subunit 6A1, mitochondrial Bos taurus 166-186 17470809-3 2007 Here, we report a coupling mechanism by a histidine (His-503) at the entrance of a proton transfer pathway to the dioxygen reduction site (D-pathway) of bovine heart cytochrome c oxidase. Histidine 53-56 cytochrome c oxidase subunit 6A1, mitochondrial Bos taurus 166-186 17475008-8 2007 Molecular docking experiments identified key residues in donor and acceptor recognition and provided insight into the catalytic mechanism of UGT glucuronidation, suggesting the human UGT1A1 residue histidine 39 (H39) as a general base and the residue aspartic acid 151 (D151) as an important electron-transfer helper. Histidine 198-207 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 141-144 17382284-3 2007 Pnc1p displays a cluster of surface histidine residues likely responsible for its co-fractionation with IDH from Ni(2+)-coupled chromatography resins. Histidine 36-45 nicotinamidase Saccharomyces cerevisiae S288C 0-5 17382284-4 2007 Researchers expressing histidine-tagged proteins in yeast should be aware of the propensity of Pnc1p to crystallize, even when overwhelmed in concentration by the protein of interest. Histidine 23-32 nicotinamidase Saccharomyces cerevisiae S288C 95-100 17485849-5 2007 Then we found that among AS2/LOB family members, ASL9 is distinct from the others in that it is exclusively regulated by the plant hormone cytokinin in a manner dependent on His-Asp phosphorelay signal transduction. Histidine 174-177 Lateral organ boundaries (LOB) domain family protein Arabidopsis thaliana 25-28 17485849-5 2007 Then we found that among AS2/LOB family members, ASL9 is distinct from the others in that it is exclusively regulated by the plant hormone cytokinin in a manner dependent on His-Asp phosphorelay signal transduction. Histidine 174-177 Lateral organ boundaries (LOB) domain family protein Arabidopsis thaliana 29-32 17485849-5 2007 Then we found that among AS2/LOB family members, ASL9 is distinct from the others in that it is exclusively regulated by the plant hormone cytokinin in a manner dependent on His-Asp phosphorelay signal transduction. Histidine 174-177 ASYMMETRIC LEAVES 2-like 9 Arabidopsis thaliana 49-53 24557667-1 2007 The fragile histidine triad (FHIT) gene, a candidate tumor suppressor gene located at 3p14.2, has been shown to be involved in the carcinogenesis of many human tissues, including digestive tract tissues. Histidine 12-21 fragile histidine triad diadenosine triphosphatase Homo sapiens 29-33 17166829-7 2007 In contrast, we found that CBP intrinsic activity was increased by Akt through threonine 1872, a consensus site for Akt in the cysteine- and histidine-rich 3 domain of CBP, indicating that such enhanced transcriptional potential of CBP did not serve to activate ERbeta. Histidine 141-150 estrogen receptor 2 Homo sapiens 262-268 17306029-5 2007 Unexpectedly, we find that His-950 in human MR, which is conserved in the MR in chimpanzee, orangutan and macaque, is glutamine in all teleost and land vertebrate MRs, including New World monkeys and prosimians. Histidine 27-30 nuclear receptor subfamily 3 group C member 2 Homo sapiens 44-46 17306029-5 2007 Unexpectedly, we find that His-950 in human MR, which is conserved in the MR in chimpanzee, orangutan and macaque, is glutamine in all teleost and land vertebrate MRs, including New World monkeys and prosimians. Histidine 27-30 nuclear receptor subfamily 3 group C member 2 Homo sapiens 74-76 17306029-7 2007 A mutation corresponding to His-950 in human MR may have been important in physiological changes associated with emergence of Old World monkeys from prosimians. Histidine 28-31 nuclear receptor subfamily 3 group C member 2 Homo sapiens 45-47 17005605-0 2007 Transmembrane domain histidines contribute to regulation of AE2-mediated anion exchange by pH. Histidine 21-31 solute carrier family 4 (anion exchanger), member 2 Mus musculus 60-63 17005605-3 2007 We have investigated the importance to pH sensitivity of the eight histidine (His) residues within the AE2 COOH-terminal transmembrane domain (TMD). Histidine 67-76 solute carrier family 4 (anion exchanger), member 2 Mus musculus 103-106 17005605-3 2007 We have investigated the importance to pH sensitivity of the eight histidine (His) residues within the AE2 COOH-terminal transmembrane domain (TMD). Histidine 78-81 solute carrier family 4 (anion exchanger), member 2 Mus musculus 103-106 17005605-10 2007 The simultaneous mutation of five or more His residues, however, greatly decreased basal AE2 activity, consistent with the inhibitory effects of DEPC modification. Histidine 42-45 solute carrier family 4 (anion exchanger), member 2 Mus musculus 89-92 17005605-11 2007 The results show that multiple TMD His residues contribute to basal AE2 activity and its sensitivity to pH(i) and pH(o). Histidine 35-38 solute carrier family 4 (anion exchanger), member 2 Mus musculus 68-71 24557626-1 2007 We detected loss of heterozygosity (LOH) and microsatellite instabilities (MSI), as well as extron expression of the fragile histidine triad (FHIT) gene in gastric carcinoma (GC), in order to evaluate their association with clinicopathological processes in gastric carcinogenesis. Histidine 125-134 fragile histidine triad diadenosine triphosphatase Homo sapiens 142-146 17137614-0 2007 Abnormal fragile histidine triad (Fhit) expression in invasive cervical adenocarcinoma: association with tumor aggressiveness. Histidine 17-26 fragile histidine triad diadenosine triphosphatase Homo sapiens 34-38 17137614-1 2007 The fragile histidine triad (FHIT) gene is a candidate tumor suppressor gene. Histidine 12-21 fragile histidine triad diadenosine triphosphatase Homo sapiens 29-33 17609851-1 2007 The fragile histidine triad (FHIT), which was located on chromosome 3p14.2, was currently considered a promising candidate for a tumor suppressor gene. Histidine 12-21 fragile histidine triad diadenosine triphosphatase Homo sapiens 29-33 17726229-1 2007 Lipopolysaccharide (LPS) is a proinflammatory and depressogenic agent whereas thyrotropin-releasing hormone (TRH; pGlu-His-Pro-NH2) is an endogenous antidepressant and neuroprotective peptide. Histidine 119-122 thyrotropin releasing hormone Rattus norvegicus 78-107 17726229-1 2007 Lipopolysaccharide (LPS) is a proinflammatory and depressogenic agent whereas thyrotropin-releasing hormone (TRH; pGlu-His-Pro-NH2) is an endogenous antidepressant and neuroprotective peptide. Histidine 119-122 thyrotropin releasing hormone Rattus norvegicus 109-112 17179900-0 2007 Investigation of the catalytic and structural roles of conserved histidines of human coproporphyrinogen oxidase using site-directed mutagenesis. Histidine 65-75 coproporphyrinogen oxidase Homo sapiens 85-111 17179900-1 2007 BACKGROUND: The catalytic contribution of four conserved histidines of human coproporphyrinogen oxidase (CPO) has been investigated using site-directed mutagenesis to change histidine (H) into alanine (A). Histidine 57-67 coproporphyrinogen oxidase Homo sapiens 77-103 17179900-1 2007 BACKGROUND: The catalytic contribution of four conserved histidines of human coproporphyrinogen oxidase (CPO) has been investigated using site-directed mutagenesis to change histidine (H) into alanine (A). Histidine 57-66 coproporphyrinogen oxidase Homo sapiens 77-103 17609151-8 2007 This chapter provides a brief overview of such techniques, describes their use in confirming histidine phosphorylation of a known PTS protein (HPr), and suggests how this approach might be adapted for large-scale identification of histidine-phosphorylated proteins in two-component systems. Histidine 93-102 haptoglobin-related protein Homo sapiens 143-146 17913635-6 2007 The cDNA for bovine IF2(mt) was expressed in Escherichia coli under the control of the T7 polymerase promoter in a vector that provides a His(6)-tag at the C-terminus of the expressed protein. Histidine 138-141 eukaryotic translation initiation factor 5B Homo sapiens 20-23 17713357-6 2007 We also found increased histidine decarboxylase (HDC) expression in activated HUCMC after 6 h of incubation, a rate-limiting enzyme responsible for the generation of histamine from histidine. Histidine 24-33 histidine decarboxylase Homo sapiens 49-52 18029758-6 2007 To clarify the pH-dependent binding mechanism of TLR3 at the structural level, we focused on some highly conserved histidine residues clustered at the N-terminal region of the TLR3 ECD. Histidine 115-124 toll like receptor 3 Homo sapiens 49-53 18029758-6 2007 To clarify the pH-dependent binding mechanism of TLR3 at the structural level, we focused on some highly conserved histidine residues clustered at the N-terminal region of the TLR3 ECD. Histidine 115-124 toll like receptor 3 Homo sapiens 176-180 17140699-3 2007 Very few modifications of [Arg(7)]-corazonin, originally isolated from cockroaches, are known, namely [His(7)]-corazonin which is expressed in certain locusts and the stick insect Carausius morosus, and [Thr(4), His(7)]-corazonin recently described from the honey bee Apis mellifera. Histidine 103-106 pro-corazonin Apis mellifera 35-44 17140699-3 2007 Very few modifications of [Arg(7)]-corazonin, originally isolated from cockroaches, are known, namely [His(7)]-corazonin which is expressed in certain locusts and the stick insect Carausius morosus, and [Thr(4), His(7)]-corazonin recently described from the honey bee Apis mellifera. Histidine 103-106 pro-corazonin Apis mellifera 111-120 17140699-3 2007 Very few modifications of [Arg(7)]-corazonin, originally isolated from cockroaches, are known, namely [His(7)]-corazonin which is expressed in certain locusts and the stick insect Carausius morosus, and [Thr(4), His(7)]-corazonin recently described from the honey bee Apis mellifera. Histidine 103-106 pro-corazonin Apis mellifera 111-120 17140699-8 2007 The third isoform, [Thr(4), His(7)]-corazonin, seems to be restricted to bees (Apidae); whereas wasps (Vespidae) and a bumble bee (Apidae) express other corazonins, specifically [His(7)]-corazonin and [Tyr(3), Gln(7), Gln(10)]-corazonin, respectively. Histidine 28-31 pro-corazonin Apis mellifera 36-45 17140699-9 2007 A novel corazonin form, [His(4), Gln(7)]-corazonin, was also detected in all South African members of the newly described insect order Mantophasmatodea. Histidine 25-28 pro-corazonin Apis mellifera 8-17 17140699-9 2007 A novel corazonin form, [His(4), Gln(7)]-corazonin, was also detected in all South African members of the newly described insect order Mantophasmatodea. Histidine 25-28 pro-corazonin Apis mellifera 41-50 17140699-10 2007 The [His(4), Gln(7)]-corazonin separates these species from the Namibian Mantophasmatodea which express [Arg(7)]-corazonin and can be used as a distinct character to distinguish these morphologically similar insects. Histidine 5-8 pro-corazonin Apis mellifera 21-30 17068338-5 2006 At the second nucleotide binding site, a glutamic acid (TAP2 Glu(632)) follows the Walker B motif, and the switch region contains a histidine (TAP2 His(661)). Histidine 132-141 transporter 2, ATP binding cassette subfamily B member Homo sapiens 143-147 17068338-5 2006 At the second nucleotide binding site, a glutamic acid (TAP2 Glu(632)) follows the Walker B motif, and the switch region contains a histidine (TAP2 His(661)). Histidine 148-151 transporter 2, ATP binding cassette subfamily B member Homo sapiens 143-147 17068338-6 2006 We found that alterations at Glu(632) and His(661) of TAP2 significantly reduced peptide translocation and/or TAP-induced major histocompatibility complex class I surface expression. Histidine 42-45 transporter 2, ATP binding cassette subfamily B member Homo sapiens 54-58 17046815-6 2006 VGLUT2s with mutations in the transmembrane-located residues Arg(184), His(128), and Glu(191) showed a dramatic loss in l-glutamate transport activity, whereas Na(+)-dependent inorganic phosphate (P(i)) uptake remained comparable to that of the wild type. Histidine 71-74 solute carrier family 17 member 6 Homo sapiens 0-6 17023418-6 2006 The differential binding of AhR by Arnt and Arnt2 can be ascribed to a single His/Pro amino acid difference in the PASB region of Arnt and Arnt2, suggesting that the PASB/PASB interaction between bHLH-PAS transcription factors plays a selective role for their specific partner molecule. Histidine 78-81 aryl hydrocarbon receptor Homo sapiens 28-31 16735073-4 2006 In order to obtain human LOX-1 and identify its mimic ligand for facilitating the study of LOX-1 function, a recombinant plasmid pPIC9K-His-hLOX-1 was structured and expressed human LOX-1 in Pichia pastoris GS115. Histidine 136-139 oxidized low density lipoprotein receptor 1 Homo sapiens 25-30 16967187-8 2006 All these findings suggested that the fused expressed His-DR inhibited the activity of natural DDR2, and relevant MMP-1 and MMP-2 expression in synoviocytes and NIH3T3 cells provoked by collagen II. Histidine 54-57 matrix metallopeptidase 13 Mus musculus 114-119 16934294-0 2006 Histidine triad-like motif of the rotavirus NSP2 octamer mediates both RTPase and NTPase activities. Histidine 0-9 reticulon 2 Homo sapiens 44-48 16978018-8 2006 KIAA1363 reactivates faster than AChE presumably due to differences in the uncoupling of the catalytic triad His upon phosphorylation. Histidine 109-112 acetylcholinesterase Mus musculus 33-37 17009983-2 2006 However, no report existed regarding the methylation status of the fragile histidine triad (FHIT) and E-cadherin genes in plasma samples of cervical cancer patients. Histidine 75-84 fragile histidine triad diadenosine triphosphatase Homo sapiens 92-96 16518858-5 2006 TAA90K-His bound to fibronectin, collagen IV, laminins-1, -5, and -10 and galectin-3 (Mac-2) but poorly to collagen I and galectin-1. Histidine 7-10 galectin 3 Homo sapiens 74-84 16518858-5 2006 TAA90K-His bound to fibronectin, collagen IV, laminins-1, -5, and -10 and galectin-3 (Mac-2) but poorly to collagen I and galectin-1. Histidine 7-10 galectin 3 Homo sapiens 86-91 16518858-8 2006 However, at low concentrations, TAA90K-His enhanced galectin-3-mediated HT-29 cell adhesion while at high concentrations, it inhibited cell adhesion. Histidine 39-42 galectin 3 Homo sapiens 52-62 16717093-2 2006 An important feature of the nucleotide exchange is the structural rearrangement of EF-Tu in the EF-Tu.EF-Ts complex caused by insertion of Phe-81 of EF-Ts between His-84 and His-118 of EF-Tu. Histidine 163-166 eukaryotic translation elongation factor 1 alpha 1 Homo sapiens 83-88 16717093-2 2006 An important feature of the nucleotide exchange is the structural rearrangement of EF-Tu in the EF-Tu.EF-Ts complex caused by insertion of Phe-81 of EF-Ts between His-84 and His-118 of EF-Tu. Histidine 163-166 eukaryotic translation elongation factor 1 alpha 1 Homo sapiens 96-101 16717093-2 2006 An important feature of the nucleotide exchange is the structural rearrangement of EF-Tu in the EF-Tu.EF-Ts complex caused by insertion of Phe-81 of EF-Ts between His-84 and His-118 of EF-Tu. Histidine 163-166 eukaryotic translation elongation factor 1 alpha 1 Homo sapiens 96-101 16717093-2 2006 An important feature of the nucleotide exchange is the structural rearrangement of EF-Tu in the EF-Tu.EF-Ts complex caused by insertion of Phe-81 of EF-Ts between His-84 and His-118 of EF-Tu. Histidine 174-177 eukaryotic translation elongation factor 1 alpha 1 Homo sapiens 83-88 16717093-2 2006 An important feature of the nucleotide exchange is the structural rearrangement of EF-Tu in the EF-Tu.EF-Ts complex caused by insertion of Phe-81 of EF-Ts between His-84 and His-118 of EF-Tu. Histidine 174-177 eukaryotic translation elongation factor 1 alpha 1 Homo sapiens 96-101 16717093-2 2006 An important feature of the nucleotide exchange is the structural rearrangement of EF-Tu in the EF-Tu.EF-Ts complex caused by insertion of Phe-81 of EF-Ts between His-84 and His-118 of EF-Tu. Histidine 174-177 eukaryotic translation elongation factor 1 alpha 1 Homo sapiens 96-101 16717093-3 2006 In this study, the contribution of His-118 to nucleotide release was studied by pre-steady state kinetic analysis of nucleotide exchange in EF-Tu mutants in which His-118 was replaced by Ala or Glu. Histidine 35-38 eukaryotic translation elongation factor 1 alpha 1 Homo sapiens 140-145 16717093-6 2006 The K(d) for GTP is increased by more than 40 times when His-118 is replaced with Glu, which may explain the inhibition by His-118 mutations of aminoacyl-tRNA binding to EF-Tu. Histidine 57-60 eukaryotic translation elongation factor 1 alpha 1 Homo sapiens 170-175 16698048-2 2006 Human FHIT (fragile histidine triad) gene is highly conserved gene whose loss of function may be important in the development and/or progression of various types of cancer. Histidine 20-29 fragile histidine triad diadenosine triphosphatase Homo sapiens 6-10 16611635-2 2006 Pyroglutamyl peptidase II (PPII), a highly specific membrane-bound omegapeptidase, removes N-terminal pyroglutamyl from thyrotropin-releasing hormone (<Glu-His-Pro-NH(2)), inactivating the peptide in the extracellular space. Histidine 159-162 thyrotropin releasing hormone Homo sapiens 120-149 16563127-11 2006 To further examine the requirement of C/EBPbeta in OM-stimulated LDLR expression, we developed a His-tagged dominant-negative mutant of C/EBPbeta (His-C/EBPbeta-P4; where P4 is plasmid 4 in our mutation series), consisting of the DNA-binding and leucine zipper domains of C/EBPbeta (amino acids 246-345). Histidine 147-150 CCAAT enhancer binding protein beta Homo sapiens 136-145 16563127-11 2006 To further examine the requirement of C/EBPbeta in OM-stimulated LDLR expression, we developed a His-tagged dominant-negative mutant of C/EBPbeta (His-C/EBPbeta-P4; where P4 is plasmid 4 in our mutation series), consisting of the DNA-binding and leucine zipper domains of C/EBPbeta (amino acids 246-345). Histidine 147-150 CCAAT enhancer binding protein beta Homo sapiens 136-145 16563127-11 2006 To further examine the requirement of C/EBPbeta in OM-stimulated LDLR expression, we developed a His-tagged dominant-negative mutant of C/EBPbeta (His-C/EBPbeta-P4; where P4 is plasmid 4 in our mutation series), consisting of the DNA-binding and leucine zipper domains of C/EBPbeta (amino acids 246-345). Histidine 147-150 CCAAT enhancer binding protein beta Homo sapiens 136-145 16749776-1 2006 Peptide dendrimers built by iteration of the diamino acid dendron Dap-His-Ser (His = histidine, Ser = Serine, Dap = diamino propionic acid) display a strong positive dendritic effect for the catalytic hydrolysis of 8-acyloxypyrene 1,3,6-trisulfonates, which proceeds with enzyme-like kinetics in aqueous medium (Delort, E.; Darbre, T.; Reymond, J.-L. J. Histidine 70-73 death associated protein Homo sapiens 66-69 16749776-1 2006 Peptide dendrimers built by iteration of the diamino acid dendron Dap-His-Ser (His = histidine, Ser = Serine, Dap = diamino propionic acid) display a strong positive dendritic effect for the catalytic hydrolysis of 8-acyloxypyrene 1,3,6-trisulfonates, which proceeds with enzyme-like kinetics in aqueous medium (Delort, E.; Darbre, T.; Reymond, J.-L. J. Histidine 70-73 death associated protein Homo sapiens 110-113 16749776-1 2006 Peptide dendrimers built by iteration of the diamino acid dendron Dap-His-Ser (His = histidine, Ser = Serine, Dap = diamino propionic acid) display a strong positive dendritic effect for the catalytic hydrolysis of 8-acyloxypyrene 1,3,6-trisulfonates, which proceeds with enzyme-like kinetics in aqueous medium (Delort, E.; Darbre, T.; Reymond, J.-L. J. Histidine 85-94 death associated protein Homo sapiens 66-69 16749776-1 2006 Peptide dendrimers built by iteration of the diamino acid dendron Dap-His-Ser (His = histidine, Ser = Serine, Dap = diamino propionic acid) display a strong positive dendritic effect for the catalytic hydrolysis of 8-acyloxypyrene 1,3,6-trisulfonates, which proceeds with enzyme-like kinetics in aqueous medium (Delort, E.; Darbre, T.; Reymond, J.-L. J. Histidine 85-94 death associated protein Homo sapiens 110-113 16513785-5 2006 When D1-His(190) is protonated, corresponding to a thermally activated state, the calculated E(m)(Y(Z)) was +1216 mV, which is as high as the E(m) for P(D1/D2). Histidine 8-11 programmed cell death 1 Homo sapiens 151-158 16380267-2 2006 The sequence corresponding to the mature lipase was subcloned in the pET-14b expression vector, with a strong T7 promoter, to construct a recombinant lipase protein containing six histidine residues at the N-terminal. Histidine 180-189 YSIRK-type signal peptide-containing protein Staphylococcus xylosus 41-47 16380267-2 2006 The sequence corresponding to the mature lipase was subcloned in the pET-14b expression vector, with a strong T7 promoter, to construct a recombinant lipase protein containing six histidine residues at the N-terminal. Histidine 180-189 YSIRK-type signal peptide-containing protein Staphylococcus xylosus 150-156 16637701-6 2006 LC-MS-MS identified four histidine residues (His 36, 81, 88, and 152) of bovine Mb that were readily adducted by HNE, whereas in porcine Mb only two histidine residues (His 24 and 36) were adducted. Histidine 25-34 myoglobin Bos taurus 80-82 16696901-3 2006 In present study, the extracellular domain of human PD-1 with a carboxyl terminal His-tag (designated as sPD-1) was expressed as inclusion bodies in Escherichia coli. Histidine 82-85 programmed cell death 1 Homo sapiens 52-56 16755491-3 2006 The origin of this variant is a mutation in codon 47 (GAC --> CAC) of the alpha2-globin gene, resulting in the replacement of asparagine by histidine during the translation process. Histidine 143-152 hemoglobin subunit alpha 2 Homo sapiens 77-90 16607940-2 2006 In this paper, hBNP was expressed as a fusion protein with a histidine tag and Ssp dnaB mini-intein which was capable of self-cleavage. Histidine 61-70 natriuretic peptide B Homo sapiens 15-19 16475789-2 2006 Myc-tagged BAFF starting at residue Gln136 was previously reported to crystallize as trimers at pH 4.5, whereas a histidine-tagged construct of BAFF, starting at residue Ala134, formed a virus-like cluster containing 60 monomers when crystallized at pH 9.0. Histidine 114-123 TNF superfamily member 13b Homo sapiens 144-148 16282320-4 2006 Yeast expression experiments demonstrated that HMA1 is involved in copper homeostasis and that deletion of its N-terminal His-domain partially affects the metal transport. Histidine 122-125 heavy metal atpase 1 Arabidopsis thaliana 47-51 16828466-5 2006 Moving in vivo, we demonstrated that subcutaneously administered his(6)CTLA-4.FasL modulates the in vivo response of infused allogeneic splenocytes. Histidine 65-68 Fas ligand (TNF superfamily, member 6) Mus musculus 78-82 16391790-4 2006 The recombinant TK1-2 prepared through E. coli expression, His-tag affinity chromatography and in vitro refolding was injected intraperitoneally once daily into nude mice 7 days after subcutaneous implantation with PC14 lung cancer cells (n=10). Histidine 59-62 thymidine kinase 2, mitochondrial Mus musculus 16-21 16429145-0 2006 Histidine button engineered into cardiac troponin I protects the ischemic and failing heart. Histidine 0-9 troponin I, cardiac 3 Mus musculus 33-51 16862454-2 2006 The changes in the distance between N(epsilon2) of His(12) and N(delta1) of His(119) at the catalytic center of RNase A upon the addition of sodium sulfate, sodium hydrogen sulfate and sodium thiocyanate were evaluated by molecular dynamic methods. Histidine 51-54 ribonuclease A family member 1, pancreatic Homo sapiens 112-119 16862454-2 2006 The changes in the distance between N(epsilon2) of His(12) and N(delta1) of His(119) at the catalytic center of RNase A upon the addition of sodium sulfate, sodium hydrogen sulfate and sodium thiocyanate were evaluated by molecular dynamic methods. Histidine 76-79 ribonuclease A family member 1, pancreatic Homo sapiens 112-119 16584607-5 2006 While there is a translation-enhancing sequence T7-g10 in the PRSETA-B7-2-PE40KDEL expression vector, so it adds 6 histidines to the N terminus of the protein of interest, this allows to purify the protein of interest by metal chelating chromatography. Histidine 115-125 CD86 molecule Homo sapiens 69-73 16884532-6 2006 The UGT1A424Thr/48Leu and UGT1A424Pro/48Val variants were generated by site-directed mutagenesis of the pcDNA3.1/V5-His-TOPO plasmid expressing wild-type UGT1A424Pro/48Leu. Histidine 116-119 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 4-9 16884532-6 2006 The UGT1A424Thr/48Leu and UGT1A424Pro/48Val variants were generated by site-directed mutagenesis of the pcDNA3.1/V5-His-TOPO plasmid expressing wild-type UGT1A424Pro/48Leu. Histidine 116-119 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 26-31 16884532-6 2006 The UGT1A424Thr/48Leu and UGT1A424Pro/48Val variants were generated by site-directed mutagenesis of the pcDNA3.1/V5-His-TOPO plasmid expressing wild-type UGT1A424Pro/48Leu. Histidine 116-119 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 26-31 16314460-6 2005 Thus, in U4 atac snRNA we identified His 270 in the spliceosomal U4/U6 snRNP-specific protein 61 K (hPrp31p) cross-linked to U 44; in the U1 snRNP we show that Leu175 of the U1 snRNP-specific 70K protein is cross-linked to U 30 of U1 snRNA. Histidine 37-40 RNA, U1 small nuclear 1 Homo sapiens 138-146 16168961-3 2005 HOXA1 contains a string of 10 histidine repeats. Histidine 30-39 homeobox A1 Homo sapiens 0-5 16175316-7 2005 Similarly, the risk associated with a long duration (>or=30 years) of menstruation also substantially differed by the SULT1A1 genotype (p for interaction = 0.05), with an OR of 4.0 (95% CI = 1.3-12.8) for women with the Arg/His genotype and 1.4 (0.8-2.5) for women with the Arg/Arg genotype. Histidine 227-230 sulfotransferase family 1A member 1 Homo sapiens 121-128 16141202-3 2005 We confirm here that the Tdp1 catalytic cycle involves a covalent reaction intermediate in which a histidine residue is connected to a DNA 3"-phosphate through a phosphoamide linkage. Histidine 99-108 tyrosyl-DNA phosphodiesterase 1 Homo sapiens 25-29 16102717-3 2005 It also allowed us to accurately determine the kinetic rate constants for the interaction between His-CypA and CsA. Histidine 98-101 ERCC excision repair 8, CSA ubiquitin ligase complex subunit Homo sapiens 111-114 15951563-8 2005 The bromo domain and cysteine- and histidine-rich domains of p300 were required for repression by cyclin D1. Histidine 35-44 E1A binding protein p300 Homo sapiens 61-65 15951563-8 2005 The bromo domain and cysteine- and histidine-rich domains of p300 were required for repression by cyclin D1. Histidine 35-44 cyclin D1 Homo sapiens 98-107 15967801-1 2005 The human gonadotropin-releasing hormone (GnRH) receptor is evolutionarily configured for high affinity binding of GnRH I ([Tyr(5),Leu(7),Arg(8)]GnRH) but at lower affinity for GnRH II ([His(5),Trp(7),Tyr(8)]GnRH). Histidine 187-190 gonadotropin releasing hormone receptor Homo sapiens 10-56 15967801-1 2005 The human gonadotropin-releasing hormone (GnRH) receptor is evolutionarily configured for high affinity binding of GnRH I ([Tyr(5),Leu(7),Arg(8)]GnRH) but at lower affinity for GnRH II ([His(5),Trp(7),Tyr(8)]GnRH). Histidine 187-190 gonadotropin releasing hormone 1 Homo sapiens 42-46 15967801-1 2005 The human gonadotropin-releasing hormone (GnRH) receptor is evolutionarily configured for high affinity binding of GnRH I ([Tyr(5),Leu(7),Arg(8)]GnRH) but at lower affinity for GnRH II ([His(5),Trp(7),Tyr(8)]GnRH). Histidine 187-190 gonadotropin releasing hormone 1 Homo sapiens 115-119 15967801-1 2005 The human gonadotropin-releasing hormone (GnRH) receptor is evolutionarily configured for high affinity binding of GnRH I ([Tyr(5),Leu(7),Arg(8)]GnRH) but at lower affinity for GnRH II ([His(5),Trp(7),Tyr(8)]GnRH). Histidine 187-190 gonadotropin releasing hormone 1 Homo sapiens 115-119 15907824-3 2005 Disruptions to gap junctional connexin40 (Cx40) have been reported in distal (i.e., apically located), but not proximal His-Purkinje conduction tissues of the HF-1b knockout mouse. Histidine 120-123 gap junction protein, alpha 5 Mus musculus 30-40 15907824-3 2005 Disruptions to gap junctional connexin40 (Cx40) have been reported in distal (i.e., apically located), but not proximal His-Purkinje conduction tissues of the HF-1b knockout mouse. Histidine 120-123 gap junction protein, alpha 5 Mus musculus 42-46 15902282-1 2005 To clarify the role of fragile histidine triad (FHIT) in hematological malignancies, we examined the methylation status and the expression level of the FHIT gene in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) cells in comparison with the methylation of the p15(INK4B) gene. Histidine 31-40 fragile histidine triad diadenosine triphosphatase Homo sapiens 48-52 15908697-7 2005 Molecular modeling of the Rad51-G103E mutant protein shows that the negatively charged glutamate residue lies on the surface of the N-terminal domain facing a positively charged patch composed of Arg-260, His-302, and Lys-305 on the ATPase core domain. Histidine 205-208 recombinase RAD51 Saccharomyces cerevisiae S288C 26-31 15963506-2 2005 To purify and study the function of the ATPase, the enzyme was truncated by five of the six metal binding domains and endowed with an N-terminal histidine-tag for affinity purification. Histidine 145-154 dynein axonemal heavy chain 8 Homo sapiens 40-46 15849248-4 2005 In wild-type deoxy myoglobin, the passage between the distal pocket and the solvent is strictly correlated to the presence/absence of a water molecule that simultaneously interacts with the distal histidine side chain and the heme iron; conversely, in the photodissociated myoglobin, the connection with the bulk solvent is always open when CO is in the vicinity of the A pyrrole ring. Histidine 197-206 myoglobin Physeter catodon 19-28 16013617-4 2005 In this paper, we present the isolation of a his-tagged lac repressor, its non-covalent immobilisation to different matrices and binding of DNA, thus enabling us to screen for combinations of ligands and stationary phases by using a building block principle. Histidine 4-7 lactase Homo sapiens 56-59 15788390-7 2005 The active site histidines, His-10 of IIA(Man) and His-15 (italics indicate HPr residues) of HPr, are in close proximity. Histidine 28-31 haptoglobin-related protein Homo sapiens 93-96 15788390-7 2005 The active site histidines, His-10 of IIA(Man) and His-15 (italics indicate HPr residues) of HPr, are in close proximity. Histidine 51-54 haptoglobin-related protein Homo sapiens 76-79 15788390-7 2005 The active site histidines, His-10 of IIA(Man) and His-15 (italics indicate HPr residues) of HPr, are in close proximity. Histidine 51-54 haptoglobin-related protein Homo sapiens 93-96 15769590-2 2005 A histidine-containing phosphotransfer protein, YPD1, represents a bifurcation point between the SLN1-YPD1-SSK1 pathway responsible for osmotic stress responses and the SLN1-YPD1-SKN7 pathway involved in cell wall biosynthesis and cell cycle control. Histidine 2-11 Ypd1p Saccharomyces cerevisiae S288C 48-52 15769590-2 2005 A histidine-containing phosphotransfer protein, YPD1, represents a bifurcation point between the SLN1-YPD1-SSK1 pathway responsible for osmotic stress responses and the SLN1-YPD1-SKN7 pathway involved in cell wall biosynthesis and cell cycle control. Histidine 2-11 histidine kinase Saccharomyces cerevisiae S288C 97-101 15769590-2 2005 A histidine-containing phosphotransfer protein, YPD1, represents a bifurcation point between the SLN1-YPD1-SSK1 pathway responsible for osmotic stress responses and the SLN1-YPD1-SKN7 pathway involved in cell wall biosynthesis and cell cycle control. Histidine 2-11 Ypd1p Saccharomyces cerevisiae S288C 102-106 15769590-2 2005 A histidine-containing phosphotransfer protein, YPD1, represents a bifurcation point between the SLN1-YPD1-SSK1 pathway responsible for osmotic stress responses and the SLN1-YPD1-SKN7 pathway involved in cell wall biosynthesis and cell cycle control. Histidine 2-11 histidine kinase Saccharomyces cerevisiae S288C 169-173 15769590-2 2005 A histidine-containing phosphotransfer protein, YPD1, represents a bifurcation point between the SLN1-YPD1-SSK1 pathway responsible for osmotic stress responses and the SLN1-YPD1-SKN7 pathway involved in cell wall biosynthesis and cell cycle control. Histidine 2-11 Ypd1p Saccharomyces cerevisiae S288C 102-106 15949315-1 2005 OBJECTIVE: To investigate the inhibition effects of fragile histidine triad (FHIT) gene on the malignant growth of A549 cell line. Histidine 60-69 fragile histidine triad diadenosine triphosphatase Homo sapiens 77-81 15741341-8 2005 This pH-sensitive aggregation behavior is explained by a dense cluster of positively charged residues at the SDF1 dimer interface that includes a histidine side chain at its center. Histidine 146-155 C-X-C motif chemokine ligand 12 Homo sapiens 109-113 15837191-5 2005 These two domains, as well as the structurally unrelated ubiquitin binding motif UIM, provide a common, crucial recognition site for ubiquitin, comprising a hydrogen-bonding acceptor for the amide group of Gly-47, and a methyl group that packs against the hydrophobic pocket of ubiquitin formed by Leu-8, Ile-44, His-68, and Val-70. Histidine 313-316 ubiquitin Saccharomyces cerevisiae S288C 57-66 15837191-5 2005 These two domains, as well as the structurally unrelated ubiquitin binding motif UIM, provide a common, crucial recognition site for ubiquitin, comprising a hydrogen-bonding acceptor for the amide group of Gly-47, and a methyl group that packs against the hydrophobic pocket of ubiquitin formed by Leu-8, Ile-44, His-68, and Val-70. Histidine 313-316 ubiquitin Saccharomyces cerevisiae S288C 133-142 15837191-5 2005 These two domains, as well as the structurally unrelated ubiquitin binding motif UIM, provide a common, crucial recognition site for ubiquitin, comprising a hydrogen-bonding acceptor for the amide group of Gly-47, and a methyl group that packs against the hydrophobic pocket of ubiquitin formed by Leu-8, Ile-44, His-68, and Val-70. Histidine 313-316 ubiquitin Saccharomyces cerevisiae S288C 133-142 15747135-3 2005 We have studied the Co(II)- and Zn(II)-binding of a series of derivatives of L36, a small zinc ribbon protein containing a (Cys)(3)His metal coordination site. Histidine 131-134 ribosomal protein L36 Homo sapiens 77-80 15674328-1 2005 This study aimed to (a) determine if DNA methylation is a mechanism of WWOX (WW domain containing oxidoreductase) and FHIT (fragile histidine triad) inactivation in lung, breast and bladder cancers; (b) examine distinct methylation patterns in neoplastic and adjacent tissues and (c) seek correlation of methylation patterns with disease status. Histidine 132-141 fragile histidine triad diadenosine triphosphatase Homo sapiens 118-122 15735016-1 2005 We used gene targeting in mice to insert a His(6)-tagged mouse c-Myc cDNA, Myc(His), head to head into the mouse immunoglobulin heavy-chain locus, Igh, just 5" of the intronic enhancer, Emu. Histidine 43-46 myelocytomatosis oncogene Mus musculus 75-78 15569679-3 2005 A recombinant toxin, His-Css4, was obtained when fused to a His tag and a thrombin cleavage site and had similar binding affinity for and effect on Na currents of rat brain sodium channels as those of the native toxin isolated from the scorpion venom. Histidine 21-24 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 Homo sapiens 25-29 15572352-4 2005 A defect in the uptake of histidine, lysine, or arginine was also observed in the vacuolar membrane vesicles of mutants YBR293w (VBA2) and YCL069w (VBA3). Histidine 26-35 Vba2p Saccharomyces cerevisiae S288C 129-133 15572352-4 2005 A defect in the uptake of histidine, lysine, or arginine was also observed in the vacuolar membrane vesicles of mutants YBR293w (VBA2) and YCL069w (VBA3). Histidine 26-35 basic amino acid transporter Saccharomyces cerevisiae S288C 148-152 15686464-6 2005 The dissociation constants of ristocetin-induced (125)I-labelled VWF binding to two forms of soluble recombinant GPIb alpha [(1)His-(302)Ala, either (145)Thr (145T) or (145)Met (145M)] were not different. Histidine 128-131 von Willebrand factor Cricetulus griseus 65-68 15650878-7 2005 Indeed, the mutation spectrums of purified His-hAID and GST-hAID matched the trinucleotide mutability indexes in Ramos cells and in msh2(-/-)ung(-/-) mice. Histidine 43-46 mutS homolog 2 Homo sapiens 132-136 15567179-1 2005 The three human SEC14-like proteins TAP1, TAP2, and TAP3 were expressed in Escherichia coli and purified by means of an amino-terminal His-tag. Histidine 135-138 SEC14 like lipid binding 4 Homo sapiens 52-56 15567419-1 2005 pH-Dependent studies of the folding kinetics and stability of a set of His to Gln point mutants were used to characterize the denatured state and transition state ensembles for the C-terminal domain of the ribosomal protein L9 (CTL9). Histidine 71-74 ribosomal protein L9 Homo sapiens 206-226 15576555-0 2005 Crystal structure of the histidine-containing phosphotransfer protein ZmHP2 from maize. Histidine 25-34 histidine-containing phosphotransfer protein 2 Zea mays 70-75 15576555-5 2005 In ZmHP2, almost all of the conserved residues among plant HPt proteins surround this histidine, probably forming the docking interface for the receiver domain of histidine kinase or the response regulator. Histidine 86-95 histidine-containing phosphotransfer protein 2 Zea mays 3-8 15609997-5 2004 On the contrary, finger 1 can use only two residues for DNA recognition, Lys550 and His553 at positions -1 and 3 of the helix, and has more relaxed sequence and site specificity than other Cys(2)His(2) zinc fingers. Histidine 84-87 Yip1 domain family member 1 Homo sapiens 17-25 15344908-9 2004 A unique zinc-finger motif composed of two contiguous Cys(2)His(2)-type fingers is common to both forms of ZFF29. Histidine 60-63 zinc finger protein 367 Homo sapiens 107-112 15569992-1 2004 The fragile histidine triad (FHIT) gene located on chromosome 3p14.2 is frequently deleted in human tumors. Histidine 12-21 fragile histidine triad diadenosine triphosphatase Homo sapiens 29-33 15355958-3 2004 It was recently reported, however, that when Myc-MAP1LC3B-His is expressed in HEK293 cells, its carboxyl terminus is not cleaved. Histidine 58-61 microtubule associated protein 1 light chain 3 beta Homo sapiens 49-57 15355958-8 2004 When MAP1LC3B-3xFLAG and Myc-MAP1LC3B-His were expressed in HEK293 cells, their carboxyl termini were cleaved, whereas there was little cleavage of mutant proteins MAP1LC3B(G120A)-3xFLAG and Myc-MAP1LC3B(G120A)-His, containing Ala in place of Gly(120). Histidine 38-41 microtubule associated protein 1 light chain 3 beta Homo sapiens 29-37 15355958-8 2004 When MAP1LC3B-3xFLAG and Myc-MAP1LC3B-His were expressed in HEK293 cells, their carboxyl termini were cleaved, whereas there was little cleavage of mutant proteins MAP1LC3B(G120A)-3xFLAG and Myc-MAP1LC3B(G120A)-His, containing Ala in place of Gly(120). Histidine 38-41 microtubule associated protein 1 light chain 3 beta Homo sapiens 29-37 15355958-8 2004 When MAP1LC3B-3xFLAG and Myc-MAP1LC3B-His were expressed in HEK293 cells, their carboxyl termini were cleaved, whereas there was little cleavage of mutant proteins MAP1LC3B(G120A)-3xFLAG and Myc-MAP1LC3B(G120A)-His, containing Ala in place of Gly(120). Histidine 38-41 microtubule associated protein 1 light chain 3 beta Homo sapiens 29-37 15474520-2 2004 Through the use of positional scanning combinatorial substrate libraries, prostasin was shown to have a preference for poly-basic substrates: in position P4 preference was for arginine or lysine; in P3 preference was for histidine, lysine or arginine; in P2 preference was for basic or large hydrophobic amino acids; and in P1 preference was for arginine and lysine. Histidine 221-230 serine protease 8 Homo sapiens 74-83 15474520-7 2004 In the presence of sub-inhibitory concentrations of zinc, the activity of prostasin increased several-fold and its substrate specificity was significantly altered in favor of a strong preference for histidine in positions P3 or P4 of the substrate. Histidine 199-208 serine protease 8 Homo sapiens 74-83 15504035-9 2004 The purified TTP was shown to be intact by N-terminal His-tag purification, C-terminal peptide sequencing, and mass spectrometry analysis. Histidine 54-57 ZFP36 ring finger protein Homo sapiens 13-16 15231689-1 2004 Fragile histidine triad (FHIT) gene plays an important role in the pathogenesis of lung cancer. Histidine 8-17 fragile histidine triad diadenosine triphosphatase Homo sapiens 25-29 15604023-1 2004 A guanine to adenine point mutation results in an arginine (R) to histidine (H) substitution in FcgammaRIIa at residue 131 that strongly impacts receptor function. Histidine 66-75 Fc gamma receptor IIa Homo sapiens 96-107 15304516-8 2004 Classical pathway regulation, both through decay acceleration and factor I cleavage of C4b, required a cluster of positively charged amino acids in CCP1 stretching into CCP2 (Arg-20, Arg-33, Arg-35, Lys-64, Lys-65, and Lys-88) as well as positively (Lys-131, Lys-133, and His-135) and negatively (Glu-99, Glu-152, and Asp-155) charged areas at opposing faces of the border region between CCPs 2 and 3. Histidine 272-275 complement C4B (Chido blood group) Homo sapiens 87-90 11451959-0 2001 Glutamate 170 of human l-3-hydroxyacyl-CoA dehydrogenase is required for proper orientation of the catalytic histidine and structural integrity of the enzyme. Histidine 109-118 enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase Homo sapiens 23-56 11451959-2 2001 Similar to other dehydrogenases, HAD contains a general acid/base, His(158), which is within hydrogen bond distance of a carboxylate, Glu(170). Histidine 67-70 enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase Homo sapiens 33-36 11566179-1 2001 We investigated the localization of histidine decarboxylase (HDC), which is the rate-limiting enzyme that generates histamine from histidine, in human aorta/coronary artery. Histidine 36-45 histidine decarboxylase Homo sapiens 61-64 11561721-0 2001 An essential histidine residue in GTP binding domain of bovine brain glutamate dehydrogenase isoproteins. Histidine 13-22 glutamate dehydrogenase 1, mitochondrial Bos taurus 69-92 11561721-1 2001 Greater than 90% of the original activity of the enzymes remained after modification of histidine residues of glutamate dehydrogenase (GDH) isoproteins from bovine brains with diethyl pyrocarbonate (DEPC). Histidine 88-97 glutamate dehydrogenase 1, mitochondrial Bos taurus 110-133 11561721-1 2001 Greater than 90% of the original activity of the enzymes remained after modification of histidine residues of glutamate dehydrogenase (GDH) isoproteins from bovine brains with diethyl pyrocarbonate (DEPC). Histidine 88-97 glutamate dehydrogenase 1, mitochondrial Bos taurus 135-138 11561721-3 2001 The influence of DEPC modified histidine residue(s) on binding of GTP to GDH isoproteins was investigated by protection studies. Histidine 31-40 glutamate dehydrogenase 1, mitochondrial Bos taurus 73-76 11561721-7 2001 These results indicate that the histidine residues may play an important role in the GTP binding on GDH isoproteins. Histidine 32-41 glutamate dehydrogenase 1, mitochondrial Bos taurus 100-103 11561721-9 2001 These results indicate that one of the histidine residues is involved in the GTP binding domain of GDH isoproteins. Histidine 39-48 glutamate dehydrogenase 1, mitochondrial Bos taurus 99-102 11493674-3 2001 One of these, designated type II GnRH (GnRH II: pGlu-His-Ser-His-Gly-Trp-Tyr-Pro-Gly-NH2), is conserved from fish to man and is widely distributed in the brain, suggesting important neuromodulatory functions such as regulating K+ channels and stimulating sexual arousal. Histidine 53-56 gonadotropin releasing hormone 2 Homo sapiens 39-46 11493674-3 2001 One of these, designated type II GnRH (GnRH II: pGlu-His-Ser-His-Gly-Trp-Tyr-Pro-Gly-NH2), is conserved from fish to man and is widely distributed in the brain, suggesting important neuromodulatory functions such as regulating K+ channels and stimulating sexual arousal. Histidine 61-64 gonadotropin releasing hormone 2 Homo sapiens 39-46 11468363-5 2001 Phosphate binds to the catalytic site of both Ang and Q117G in essentially the same manner observed in the RNase A-phosphate complex, forming hydrogen bonds with the side chains of His 13, His 114, and Gln 12, and the main chain of Leu 115; it makes an additional interaction with the Lys 40 ammonium group in the Ang complex. Histidine 181-184 angiogenin Homo sapiens 46-49 11468363-5 2001 Phosphate binds to the catalytic site of both Ang and Q117G in essentially the same manner observed in the RNase A-phosphate complex, forming hydrogen bonds with the side chains of His 13, His 114, and Gln 12, and the main chain of Leu 115; it makes an additional interaction with the Lys 40 ammonium group in the Ang complex. Histidine 189-192 angiogenin Homo sapiens 46-49 11352900-6 2001 Two histidine residues in the extracellular loop between transmembrane domains three and four of EAAT4 appear to confer Zn(2+) inhibition of the anion conductance. Histidine 4-13 solute carrier family 1 member 6 Homo sapiens 97-102 11415452-13 2001 Our results reveal that Cys-396 and His-480 of CopB are key residues for ATPase function, and similar roles are suggested for Cys-1000 and His-1069 of Menkes and Wilson ATPases respectively. Histidine 36-39 dynein axonemal heavy chain 8 Homo sapiens 73-79 11423433-3 2001 Previous studies revealed that Cu(2+) binds to the unstructured N-terminal PrP(C) segment (residues 23-120) through conserved histidine residues. Histidine 126-135 prion protein Mus musculus 75-81 11453994-8 2001 The enzymatic activity of purified His-tagged GST T1-1 variants expressed in Escherichia coli was markedly reduced with both dichloromethane and the alternative substrate 1,2-epoxy-3-(4"-nitrophenoxy)propane. Histidine 35-38 glutathione S-transferase theta 1 Rattus norvegicus 46-52 11390663-11 2001 Finally, profiling of a gcn4Delta mutant uncovered an alternative induction pathway operating at many Gcn4p target genes in histidine-starved cells. Histidine 124-133 amino acid starvation-responsive transcription factor GCN4 Saccharomyces cerevisiae S288C 102-107 11702710-4 2001 The recombinant 6 x His-GDF-8 fusion protein expressed in the Top10 cells was purified by Ni(+)-Affinity Chromatography for future study. Histidine 20-23 myostatin Gallus gallus 24-29 11389064-0 2001 Abnormal fragile histidine triad (FHIT) expression in advanced cervical carcinoma: a poor prognostic factor. Histidine 17-26 fragile histidine triad diadenosine triphosphatase Homo sapiens 34-38 11145957-8 2001 At pH 5.5, the affinity of the wild-type peptide for heparin/heparan sulfate was increased, implying a role for histidine residues at positions 6 and 28 of pro-IAPP. Histidine 112-121 islet amyloid polypeptide Homo sapiens 160-164 11339812-2 2001 Utilizing an efficient heterologous expression system that produces a histidine-tagged form of the hydrophilic, diaphorase domain of the enzyme, site-directed mutagenesis has been used to generate cb5r mutants with substitutions at position 91 in the primary sequence. Histidine 70-79 dihydrolipoamide dehydrogenase Homo sapiens 112-122 11278664-6 2001 His(348) in ST8Sia II and His(331) in ST8Sia IV, respectively) within the sialyl motif VS in all sialyltransferase genes cloned to date. Histidine 0-3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 Homo sapiens 38-47 11278664-6 2001 His(348) in ST8Sia II and His(331) in ST8Sia IV, respectively) within the sialyl motif VS in all sialyltransferase genes cloned to date. Histidine 26-29 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 Homo sapiens 38-47 11278664-7 2001 Mutant ST8Sia II and IV enzymes in which this His residue was changed to Lys showed no detectable enzyme activity, even though they were folded correctly and could bind to CDP-hexanolamine, suggesting the importance of the His residue for their catalytic activity. Histidine 46-49 cut like homeobox 1 Homo sapiens 172-175 11278668-0 2001 Heparin-binding histidine and lysine residues of rat selenoprotein P. Histidine 16-25 selenoprotein P Rattus norvegicus 53-68 11278668-11 2001 The present results indicate that histidine is a constituent of the heparin-binding site of selenoprotein P. Histidine 34-43 selenoprotein P Rattus norvegicus 92-107 11278668-12 2001 The presence of histidine, the pK(a) of which is 7.0, explains the release of selenoprotein P from heparin binding as pH rises above 7.0. Histidine 16-25 selenoprotein P Rattus norvegicus 78-93 11325823-1 2001 Allele loss and loss of expression of fragile histidine triad (FHIT), a putative tumor suppressor gene located in chromosome region 3p14.2, are frequent in several types of cancers. Histidine 46-55 fragile histidine triad diadenosine triphosphatase Homo sapiens 63-67 11382545-0 2001 Dietary supplements of mixtures of indispensable amino acids lacking threonine, phenylalanine or histidine increase the activity of hepatic threonine dehydrogenase, phenylalanine hydroxylase or histidase, respectively, and prevent growth depressions in chicks caused by dietary excesses of threonine, phenylalanine, or histidine* Experiments were carried out to determine whether the addition of a mixture of indispensable amino acids (IAA) lacking in threonine, phenylalanine or histidine, respectively, to a nutritionally complete diet would increase the hepatic activities of the rate-limiting enzymes for catabolism of threonine, phenylalanine or histidine and prevent the adverse effects of the amino acid on growth when the dietary level of the amino acid is excessive. Histidine 97-106 phenylalanine hydroxylase Homo sapiens 165-190 11327770-5 2001 Here, we present the solution structure of a C-terminal fragment of IF(1) (44-84) containing all five of the histidine residues present in the sequence. Histidine 109-118 ATP synthase inhibitory factor subunit 1 Bos taurus 68-73 11287669-8 2001 In addition, complementation assay and identification of the mutation site of another pleiotropic mutant, cia5, revealed that His-54 within the putative zinc-finger motif of the CCM1 is crucial to its regulatory function. Histidine 126-129 uncharacterized protein Chlamydomonas reinhardtii 178-182 11261897-1 2001 The purpose of this investigation was to study the effectiveness of two nickel-binding amino acids, histidine (His) and cysteine (Cys), to prevent the inhibitory action of Ni2+ on testosterone (T) production by mouse primary Leydig cell culture. Histidine 100-109 vacuole membrane protein 1 Mus musculus 172-175 11261897-1 2001 The purpose of this investigation was to study the effectiveness of two nickel-binding amino acids, histidine (His) and cysteine (Cys), to prevent the inhibitory action of Ni2+ on testosterone (T) production by mouse primary Leydig cell culture. Histidine 111-114 vacuole membrane protein 1 Mus musculus 172-175 11261897-12 2001 Our results show that both His and Cys are able to moderate the effects of Ni2+ on Leydig cell T production, depending on the concentration of this metal ion, as well as on amino acid. Histidine 27-30 vacuole membrane protein 1 Mus musculus 75-78 11261897-13 2001 However, at higher Ni2+ concentrations the complete protection by His or Cys is only temporary. Histidine 66-69 vacuole membrane protein 1 Mus musculus 19-22 11237699-1 2001 A histidine-tagged, carboxy-terminal fragment of the murine double minute 2 gene product, p90(MDM2), was purified by Ni--NTA chromatography and preparative gel electrophoresis. Histidine 2-11 transferrin receptor Mus musculus 90-93 11230563-3 2001 By employing the well-known His-->Asp phosphorelay systems in both the fission yeast and Escherichia coli, evidence is presented showing that the AHK4 His-kinase has an ability to serve as a cytokinin-responsive environmental sensor. Histidine 28-31 CHASE domain containing histidine kinase protein Arabidopsis thaliana 149-153 11341960-2 2001 Alignment of the amino acid sequences of FAE1 KCS, KCS1, and five other putative elongase condensing enzymes (KCSs) revealed the presence of six conserved cysteine and four conserved histidine residues. Histidine 183-192 3-ketoacyl-CoA synthase 18 Arabidopsis thaliana 41-45 11341914-0 2001 Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity. Histidine 88-97 homoserine dehydrogenase Saccharomyces cerevisiae S288C 26-50 11341914-6 2001 UV difference spectra revealed an increase in absorbance at 240 nm for DEPC-modified HSD consistent with the modification of two histidines (His) per subunit. Histidine 129-139 homoserine dehydrogenase Saccharomyces cerevisiae S288C 85-88 11341914-6 2001 UV difference spectra revealed an increase in absorbance at 240 nm for DEPC-modified HSD consistent with the modification of two histidines (His) per subunit. Histidine 141-144 homoserine dehydrogenase Saccharomyces cerevisiae S288C 85-88 11341914-7 2001 Amino acid sequence alignment of HSD illustrated the conservation of two His residues among HSDs. Histidine 73-76 homoserine dehydrogenase Saccharomyces cerevisiae S288C 33-36 11133756-2 2001 This interaction involves the A1 domain of vWF and the N-terminal extracellular region of GP Ibalpha (His-1-Glu-282), and it can also be induced under static conditions by the modulators ristocetin and botrocetin. Histidine 102-105 von Willebrand factor Cricetulus griseus 43-46 11115560-2 2001 The majority (4/5) of the patients had LOH at or close to the fragile histidine triad (FHIT) gene (3p14.2; D3S1300), which is a candidate tumor suppressor gene for many cancer types. Histidine 70-79 fragile histidine triad diadenosine triphosphatase Homo sapiens 87-91 12120225-1 2001 BACKGROUND/AIMS: This study attempts to identify the biochemical alterations in human cationic trypsinogen and trypsin caused by the hereditary pancreatitis-associated mutations Arg117-->His and Asn21-->Ile. Histidine 190-193 serine protease 1 Homo sapiens 86-106 11199158-8 2001 In addition, normal and neoplastic cells expressed fragile histidine triad (FHIT) protein; surprisingly, some pagetoid cells did not. Histidine 59-68 fragile histidine triad diadenosine triphosphatase Bos taurus 76-80 11085938-0 2000 Association of FHIT (fragile histidine triad), a candidate tumour suppressor gene, with the ubiquitin-conjugating enzyme hUBC9. Histidine 29-38 fragile histidine triad diadenosine triphosphatase Homo sapiens 15-19 11085938-0 2000 Association of FHIT (fragile histidine triad), a candidate tumour suppressor gene, with the ubiquitin-conjugating enzyme hUBC9. Histidine 29-38 ubiquitin conjugating enzyme E2 I Homo sapiens 121-126 11085938-1 2000 FHIT (fragile histidine triad), a candidate tumour suppressor gene, has recently been identified at chromosomal region 3p14.2, and deletions of the gene have been reported in many types of human cancer. Histidine 14-23 fragile histidine triad diadenosine triphosphatase Homo sapiens 0-4 11093802-0 2000 Importance of histidine residues for the function of the human liver UDP-glucuronosyltransferase UGT1A6: evidence for the catalytic role of histidine 370. Histidine 14-23 UDP glucuronosyltransferase family 1 member A6 Homo sapiens 97-103 11093802-0 2000 Importance of histidine residues for the function of the human liver UDP-glucuronosyltransferase UGT1A6: evidence for the catalytic role of histidine 370. Histidine 140-149 UDP glucuronosyltransferase family 1 member A6 Homo sapiens 97-103 11095676-3 2000 Bas1p is a Myb-related transcription factor that acts together with the homeodomain-related Bas2p (Pho2p) to regulate purine and histidine biosynthesis genes in response to extracellular purine limitation. Histidine 129-138 Bas1p Saccharomyces cerevisiae S288C 0-5 11169249-2 2000 Both alleles differ from DPB1*0402 by a single nucleotide: DPB1*8201 has a difference at position 359 (codon 91) leading to an amino acid change from arg to his, making this position a new polymorphic site; DPB1*8301 has a difference at position 280 (codon 65) changing the amino acid from ile to phe. Histidine 157-160 major histocompatibility complex, class II, DP beta 1 Homo sapiens 25-29 11169249-2 2000 Both alleles differ from DPB1*0402 by a single nucleotide: DPB1*8201 has a difference at position 359 (codon 91) leading to an amino acid change from arg to his, making this position a new polymorphic site; DPB1*8301 has a difference at position 280 (codon 65) changing the amino acid from ile to phe. Histidine 157-160 major histocompatibility complex, class II, DP beta 1 Homo sapiens 59-63 11169249-2 2000 Both alleles differ from DPB1*0402 by a single nucleotide: DPB1*8201 has a difference at position 359 (codon 91) leading to an amino acid change from arg to his, making this position a new polymorphic site; DPB1*8301 has a difference at position 280 (codon 65) changing the amino acid from ile to phe. Histidine 157-160 major histocompatibility complex, class II, DP beta 1 Homo sapiens 59-63 11018721-2 2000 The murine Unp oncoprotein and its human homologue, Unph, both contain regions similar to the conserved Cys and His boxes common to all the Ubps. Histidine 112-115 ubiquitin specific peptidase 4 (proto-oncogene) Mus musculus 11-14 11018721-4 2000 Mutation of the conserved Unp Cys and His residues abolishes this activity, and identifies the likely His residue in the catalytic triad. Histidine 102-105 ubiquitin specific peptidase 4 (proto-oncogene) Mus musculus 26-29 10951267-2 2000 Histidine decarboxylase, the only enzyme that catalyzes the formation of histamine from L-histidine, is an essential regulator of histamine levels. Histidine 88-99 histidine decarboxylase Homo sapiens 0-23 11007995-9 2000 Interestingly, the human fragile histidine triad (Fhit) tumor suppressor protein appears to be a typical Np(3)N" hydrolase. Histidine 33-42 fragile histidine triad diadenosine triphosphatase Homo sapiens 50-54 11007995-16 2000 In contrast, the Schizosaccharomyces pombe Ap(4)A/Ap(3)A hydrolase, the human Fhit protein, and the yeast Np(n)N" phosphorylases belong to a superfamily GAFH, which includes the histidine triad proteins. Histidine 178-187 fragile histidine triad diadenosine triphosphatase Homo sapiens 78-82 10951567-5 2000 Mutating W342 to aspartate (D), lysine (K) or histidine (H) also inactivated c-Raf whether assayed as a purified immunoprecipitate or when recruited to the plasma membrane. Histidine 46-55 Raf-1 proto-oncogene, serine/threonine kinase Homo sapiens 77-82 10889019-4 2000 61(98))Glu mutation markedly decreased the affinity for a series of GnRH analogues containing the native His(2) residue. Histidine 105-108 gonadotropin releasing hormone 1 Homo sapiens 68-72 10931311-0 2000 Functional roles of conserved amino acid residues surrounding the phosphorylatable histidine of the yeast phosphorelay protein YPD1. Histidine 83-92 Ypd1p Saccharomyces cerevisiae S288C 127-131 10931311-1 2000 The histidine-containing phosphotransfer (HPt) protein YPD1 is an osmoregulatory protein in yeast that facilitates phosphoryl transfer between the two response regulator domains associated with SLN1 and SSK1. Histidine 4-13 Ypd1p Saccharomyces cerevisiae S288C 55-59 10931311-1 2000 The histidine-containing phosphotransfer (HPt) protein YPD1 is an osmoregulatory protein in yeast that facilitates phosphoryl transfer between the two response regulator domains associated with SLN1 and SSK1. Histidine 4-13 histidine kinase Saccharomyces cerevisiae S288C 194-198 10860499-0 2000 Histidine-tagged ubiquitin substitutes for wild-type ubiquitin in Saccharomyces cerevisiae and facilitates isolation and identification of in vivo substrates of the ubiquitin pathway. Histidine 0-9 ubiquitin Saccharomyces cerevisiae S288C 17-26 10860499-0 2000 Histidine-tagged ubiquitin substitutes for wild-type ubiquitin in Saccharomyces cerevisiae and facilitates isolation and identification of in vivo substrates of the ubiquitin pathway. Histidine 0-9 ubiquitin Saccharomyces cerevisiae S288C 53-62 10860499-0 2000 Histidine-tagged ubiquitin substitutes for wild-type ubiquitin in Saccharomyces cerevisiae and facilitates isolation and identification of in vivo substrates of the ubiquitin pathway. Histidine 0-9 ubiquitin Saccharomyces cerevisiae S288C 53-62 10860499-2 2000 The utility of a N-terminal histidine-tagged ubiquitin (HisUb) for in vivo conjugation and isolation of ubiquitinated proteins by metal chelation chromatography is conditioned by the requirement that HisUb conjugate to the same set of proteins as wild-type ubiquitin. Histidine 28-37 ubiquitin Saccharomyces cerevisiae S288C 45-54 10860499-2 2000 The utility of a N-terminal histidine-tagged ubiquitin (HisUb) for in vivo conjugation and isolation of ubiquitinated proteins by metal chelation chromatography is conditioned by the requirement that HisUb conjugate to the same set of proteins as wild-type ubiquitin. Histidine 28-37 ubiquitin Saccharomyces cerevisiae S288C 104-113 10850413-1 2000 Hemizygous deletions of the fragile histidine triad (FHIT) gene at human chromosome band 3p14.2 and down-regulation of its gene product are found in the majority of renal cell carcinomas (RCCs). Histidine 36-45 fragile histidine triad diadenosine triphosphatase Homo sapiens 53-57 10856480-7 2000 RESULT(S): Two different mutations were detected on CYP17: One was a deletion of the phenylalanine codon (TTC) at either amino acid 53 or 54 in exon 1, and the other was a missense mutation with the substitution of histidine (CAC) by leucine (CTC) at position 373 in exon 6. Histidine 215-224 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 52-57 10747932-6 2000 These analyses identified a subset of cysteine and histidine residues required for stimulation of late gene expression, physical interaction with E1b 55k, and p53 destabilization. Histidine 51-60 branched chain keto acid dehydrogenase E1 subunit beta Homo sapiens 146-149 10893046-10 2000 CONCLUSIONS: L-Histidine uptaken by rat BMEC was shown to be converted to histamine, suggesting that HDC plays an important role in BBB. Histidine 13-24 histidine decarboxylase Rattus norvegicus 101-104 10832607-11 2000 These results indicate that histidine increases interstitial adenosine concentration via NA release-mediated activation of ecto-5"-nucleotidase. Histidine 28-37 5' nucleotidase, ecto Rattus norvegicus 123-143 10779594-10 2000 The mutant His-485-->Gln had a normal K(m) for glutathione disulphide reduction but only 0.8% residual catalytic activity when compared with wild-type GR, which confirms its function as an acid/base catalyst. Histidine 11-14 glutathione reductase Plasmodium falciparum 3D7 154-156 10985924-7 2000 If DA was not removed, [3-Me-His(2)]-TRH was ineffective. Histidine 29-32 thyrotropin releasing hormone Homo sapiens 37-40 10718748-0 2000 Mutation of histidine 286 of the human P2X4 purinoceptor removes extracellular pH sensitivity. Histidine 12-21 purinergic receptor P2X 4 Homo sapiens 39-43 10718748-8 2000 Site-directed mutagenesis of histidine 286 (H286) to alanine completely abolished the pH sensitivity of the P2X4 receptor at all agonist concentrations. Histidine 29-38 purinergic receptor P2X 4 Homo sapiens 108-112 10718748-10 2000 Mutagenesis of the other three histidines present in the P2X4 sequence had no effect on pH sensitivity. Histidine 31-41 purinergic receptor P2X 4 Homo sapiens 57-61 10691967-3 2000 The cDNA sequences of C. elegans predict two catalases very similar to each other throughout the molecule, except for the short C-terminal sequence; catalase-2 (500 residues long) carries a peroxisomal targeting signal 1-like sequence (Ser-His-Ile), whereas catalase-1 does not. Histidine 240-243 Catalase-2 Caenorhabditis elegans 149-159 10745170-1 2000 The FHIT (fragile histidine triad) gene at chromosome 3p14.2 spans the FRA3B fragile site and encodes for a diadenosine triphosphate hydrolase-type protein. Histidine 18-27 fragile histidine triad diadenosine triphosphatase Homo sapiens 4-8 10745170-1 2000 The FHIT (fragile histidine triad) gene at chromosome 3p14.2 spans the FRA3B fragile site and encodes for a diadenosine triphosphate hydrolase-type protein. Histidine 18-27 fragile histidine triad diadenosine triphosphatase Homo sapiens 71-76 10745171-1 2000 Genetic alterations at the FHIT (fragile histidine triad) tumor suppressor gene have been found in various human cancers. Histidine 41-50 fragile histidine triad diadenosine triphosphatase Homo sapiens 27-31 10762004-12 2000 The same was observed for the haplotype SULT1A1*His/SULT1A2*Thr, whose frequency was 0.35. Histidine 48-51 sulfotransferase family 1A member 1 Homo sapiens 40-47 10762004-12 2000 The same was observed for the haplotype SULT1A1*His/SULT1A2*Thr, whose frequency was 0.35. Histidine 48-51 sulfotransferase family 1A member 2 Homo sapiens 52-59 10671479-1 2000 Fhit, a member of the histidine triad superfamily of nucleotide-binding proteins, binds and cleaves diadenosine polyphosphates and functions as a tumor suppressor in human epithelial cancers. Histidine 22-31 fragile histidine triad diadenosine triphosphatase Homo sapiens 0-4 10671535-3 2000 Amino acid sequence alignment of the 2-enoyl-CoA hydratase 2 domain in human MFE-2 with other MFE-2s reveals conserved protic residues: Tyr-347, Glu-366, Asp-370, His-406, Glu-408, Tyr-410, Asp-490, Tyr-505, Asp-510, His-515, Asp-517, and His-532. Histidine 163-166 hydroxysteroid 17-beta dehydrogenase 4 Homo sapiens 77-82 10671535-3 2000 Amino acid sequence alignment of the 2-enoyl-CoA hydratase 2 domain in human MFE-2 with other MFE-2s reveals conserved protic residues: Tyr-347, Glu-366, Asp-370, His-406, Glu-408, Tyr-410, Asp-490, Tyr-505, Asp-510, His-515, Asp-517, and His-532. Histidine 163-166 hydroxysteroid 17-beta dehydrogenase 4 Homo sapiens 94-99 10671535-3 2000 Amino acid sequence alignment of the 2-enoyl-CoA hydratase 2 domain in human MFE-2 with other MFE-2s reveals conserved protic residues: Tyr-347, Glu-366, Asp-370, His-406, Glu-408, Tyr-410, Asp-490, Tyr-505, Asp-510, His-515, Asp-517, and His-532. Histidine 217-220 hydroxysteroid 17-beta dehydrogenase 4 Homo sapiens 77-82 10671535-3 2000 Amino acid sequence alignment of the 2-enoyl-CoA hydratase 2 domain in human MFE-2 with other MFE-2s reveals conserved protic residues: Tyr-347, Glu-366, Asp-370, His-406, Glu-408, Tyr-410, Asp-490, Tyr-505, Asp-510, His-515, Asp-517, and His-532. Histidine 217-220 hydroxysteroid 17-beta dehydrogenase 4 Homo sapiens 94-99 10671535-3 2000 Amino acid sequence alignment of the 2-enoyl-CoA hydratase 2 domain in human MFE-2 with other MFE-2s reveals conserved protic residues: Tyr-347, Glu-366, Asp-370, His-406, Glu-408, Tyr-410, Asp-490, Tyr-505, Asp-510, His-515, Asp-517, and His-532. Histidine 217-220 hydroxysteroid 17-beta dehydrogenase 4 Homo sapiens 77-82 10671535-3 2000 Amino acid sequence alignment of the 2-enoyl-CoA hydratase 2 domain in human MFE-2 with other MFE-2s reveals conserved protic residues: Tyr-347, Glu-366, Asp-370, His-406, Glu-408, Tyr-410, Asp-490, Tyr-505, Asp-510, His-515, Asp-517, and His-532. Histidine 217-220 hydroxysteroid 17-beta dehydrogenase 4 Homo sapiens 94-99 10652256-7 2000 The HNE-mediated activation of caspases, cleavage of PARP and DNA fragmentation were blocked by antioxidants cysteine, N-acety-L-cysteine and dithiothreitol, but not by two other HNE-reactive amino acids lysine and histidine, or by cystine, the oxidized form of cysteine. Histidine 215-224 caspase 8 Homo sapiens 31-39 10675363-4 2000 Because the single nucleotide polymorphism in FcgammaRIIA - which encodes histidine or arginine at position 131 - strongly influences IgG2 binding, we determined this polymorphism"s effect on CRP binding. Histidine 74-83 Fc gamma receptor IIa Homo sapiens 46-57 10888270-1 2000 Histamine is produced from histidine by histidine decarboxylase (HDC) in many cells including normal and malignant lymphocytes. Histidine 27-36 histidine decarboxylase Homo sapiens 40-63 10888270-1 2000 Histamine is produced from histidine by histidine decarboxylase (HDC) in many cells including normal and malignant lymphocytes. Histidine 27-36 histidine decarboxylase Homo sapiens 65-68 10631090-0 2000 Histidine modifying agents abolish pyruvate dehydrogenase kinase activity. Histidine 0-9 pyruvate dehydrogenase kinase Arabidopsis thaliana 35-64 10648838-0 2000 Identification of the two histidine residues responsible for the inhibition by malonyl-CoA in peroxisomal carnitine octanoyltransferase from rat liver. Histidine 26-35 carnitine O-octanoyltransferase Rattus norvegicus 106-135 10620501-6 2000 A 12-residue spacer, Thr-Arg-His-Arg-Gln-Pro-Arg-Gly-Trp-Glu-Gln-Leu, containing the recognition site for the protease furin, was incorporated between the toxin and the ligand to generate restrictocin-spacer-anti-TFR(scFv) and anti-TFR(scFv)-spacer-restrictocin. Histidine 29-32 furin, paired basic amino acid cleaving enzyme Homo sapiens 119-124 10681067-5 2000 The cDNA of Cpr6 was cloned into a pRSET A-plasmid with an N-terminal 6 x histidine-tag (his-tag) and transformed into the BL21[DE3]pLysS strain. Histidine 74-83 peptidylprolyl isomerase CPR6 Saccharomyces cerevisiae S288C 12-16 10681067-5 2000 The cDNA of Cpr6 was cloned into a pRSET A-plasmid with an N-terminal 6 x histidine-tag (his-tag) and transformed into the BL21[DE3]pLysS strain. Histidine 74-77 peptidylprolyl isomerase CPR6 Saccharomyces cerevisiae S288C 12-16 11255560-1 2000 Gonadotropin-releasing hormone (GnRH) is a decapeptide (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly.NH2) which is produced from a precursor polypeptide in hypothalamic neurons and secreted in a pulsatile fashion to stimulate the secretion of LH and FSH via its interaction with a cognate receptor on gonadotropes. Histidine 61-64 gonadotropin releasing hormone 1 Homo sapiens 0-30 11255560-1 2000 Gonadotropin-releasing hormone (GnRH) is a decapeptide (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly.NH2) which is produced from a precursor polypeptide in hypothalamic neurons and secreted in a pulsatile fashion to stimulate the secretion of LH and FSH via its interaction with a cognate receptor on gonadotropes. Histidine 61-64 gonadotropin releasing hormone 1 Homo sapiens 32-36 10701841-6 2000 Therefore, both GST-SStp and His-S-SStp can be used as affinity-tagged substrates to study prokaryotic chaperone/transit peptide interactions as well as to provide a novel functional probe to study the dynamics of DnaK/DnaJ/GrpE interactions in vivo. Histidine 29-32 GrpE like 1, mitochondrial Homo sapiens 224-228 11025357-2 2000 AIMS: This study was designed to investigate how water extracts (WE) of Hp applied on rat gastric mucosa affect gastric secretion and mucosal histamine concentration as well as the gene expression for histamine decarboxylase (HDC), the key enzyme converting histidine to histamine and for interleukin-1beta (IL-1beta), the important proinflammatory cytokine. Histidine 258-267 histidine decarboxylase Rattus norvegicus 201-224 11025357-2 2000 AIMS: This study was designed to investigate how water extracts (WE) of Hp applied on rat gastric mucosa affect gastric secretion and mucosal histamine concentration as well as the gene expression for histamine decarboxylase (HDC), the key enzyme converting histidine to histamine and for interleukin-1beta (IL-1beta), the important proinflammatory cytokine. Histidine 258-267 histidine decarboxylase Rattus norvegicus 226-229 10585575-1 2000 We have reported a significant frequency of an alteration of the fragile histidine triad (fhit) gene in squamous-cell carcinoma of the uterine cervix (series 1). Histidine 73-82 fragile histidine triad diadenosine triphosphatase Homo sapiens 90-94 10984068-2 2000 The hypothalamic thyrotropin-releasing hormone (TRH) was the first chemically defined hypophyseotropic hormone with the primary structure pGLU-HIS-PRO.NH2. Histidine 143-146 thyrotropin releasing hormone Homo sapiens 17-46 10984068-2 2000 The hypothalamic thyrotropin-releasing hormone (TRH) was the first chemically defined hypophyseotropic hormone with the primary structure pGLU-HIS-PRO.NH2. Histidine 143-146 thyrotropin releasing hormone Homo sapiens 48-51 10608884-5 1999 N-SMase activity in cells overexpressing the protein with hexa-histidine tag was immunoprecipitated with anti-hexa-histidine antibody. Histidine 63-72 sphingomyelin phosphodiesterase 2 Homo sapiens 0-7 10608884-5 1999 N-SMase activity in cells overexpressing the protein with hexa-histidine tag was immunoprecipitated with anti-hexa-histidine antibody. Histidine 115-124 sphingomyelin phosphodiesterase 2 Homo sapiens 0-7 10606511-4 1999 It reveals that residues Gln-14, His-15, Lys-38, Thr-42, and His-128 at the active site are conserved as in all other RNase A homologues. Histidine 33-36 ribonuclease A family member 1, pancreatic Homo sapiens 118-125 10606511-4 1999 It reveals that residues Gln-14, His-15, Lys-38, Thr-42, and His-128 at the active site are conserved as in all other RNase A homologues. Histidine 61-64 ribonuclease A family member 1, pancreatic Homo sapiens 118-125 10585483-4 1999 ArcB is a tripartite kinase, possessing a primary transmitter, a receiver, and a secondary transmitter domain that catalyzes the phosphorylation of ArcA via a His --> Asp --> His --> Asp phosphorelay, as well as the dephosphorylation of ArcA-P by a reverse phosphorelay. Histidine 181-184 arginine deiminase Escherichia coli 148-152 10585483-4 1999 ArcB is a tripartite kinase, possessing a primary transmitter, a receiver, and a secondary transmitter domain that catalyzes the phosphorylation of ArcA via a His --> Asp --> His --> Asp phosphorelay, as well as the dephosphorylation of ArcA-P by a reverse phosphorelay. Histidine 181-184 arginine deiminase Escherichia coli 246-250 10570056-1 1999 A vasoactive intestinal polypeptide (VIP) analog, acylated on the amino-terminal histidine by hexanoic acid (C(6)-VIP), behaved as a VPAC(2) preferring agonist in binding and functional studies on human VIP receptors, and radioiodinated C(6)-VIP was a suitable ligand for binding studies on wild-type and chimeric receptors. Histidine 81-90 vasoactive intestinal peptide receptor 2 Homo sapiens 133-140 10551739-1 1999 The expression of Fhit (fragile histidine triad) protein in oral squamous cell carcinoma (OSCC) and adjacent oral epithelium was evaluated by immunohistochemistry on formalin-fixed paraffin-embedded blocks of 32 cases of OSCC. Histidine 32-41 fragile histidine triad diadenosine triphosphatase Homo sapiens 18-22 10669907-3 1999 Intraperitoneal injection of L-histidine also resulted in an increase in rCBF in the hippocampus, in parallel with elevation of histamine content in the brain. Histidine 29-40 CCAAT/enhancer binding protein zeta Rattus norvegicus 73-77 10669907-4 1999 The increase in rCBF in the hippocampus induced by L-histidine was antagonized by both H1 and H2 antagonists (diphenhydramine, pyrilamine and zolantidine). Histidine 51-62 CCAAT/enhancer binding protein zeta Rattus norvegicus 16-20 10669907-5 1999 In addition, when both antagonists were injected simultaneously, an additive effect was observed in antagonism of the L-histidine-induced increase in rCBF. Histidine 118-129 CCAAT/enhancer binding protein zeta Rattus norvegicus 150-154 10669907-6 1999 L-Histidine caused no marked changes in blood pressure even at a dose of 1,500 mg/kg, which showed an increase in rCBF in the hippocampus. Histidine 0-11 CCAAT/enhancer binding protein zeta Rattus norvegicus 114-118 10608665-6 1999 In vitro experiments demonstrated that the putative signaling factors can transfer the phosphoryl group from His-80 of ZmHP2 to Asp-90 of ZmRRs. Histidine 109-112 histidine-containing phosphotransfer protein 2 Zea mays 119-124 10527871-4 1999 UCH-6 belonged to members of the UCH family containing highly conserved Cys, His, and Asp domains and showed 86% amino acid identity to human UCH-L3. Histidine 77-80 ubiquitin C-terminal hydrolase L3 Gallus gallus 0-5 10512701-0 1999 Conservation of structure and function among histidine-containing phosphotransfer (HPt) domains as revealed by the crystal structure of YPD1. Histidine 45-54 Ypd1p Saccharomyces cerevisiae S288C 136-140 10512701-7 1999 Structure-based comparisons of YPD1 to other proteins having a similar function, such as the Escherichia coli ArcB histidine-containing phosphotransfer (HPt) domain and the P1 domain of the CheA kinase, revealed that the helical bundle and several structural features around the active-site histidine residue are conserved between the prokaryotic and eukaryotic kingdoms. Histidine 115-124 Ypd1p Saccharomyces cerevisiae S288C 31-35 10512701-7 1999 Structure-based comparisons of YPD1 to other proteins having a similar function, such as the Escherichia coli ArcB histidine-containing phosphotransfer (HPt) domain and the P1 domain of the CheA kinase, revealed that the helical bundle and several structural features around the active-site histidine residue are conserved between the prokaryotic and eukaryotic kingdoms. Histidine 291-300 Ypd1p Saccharomyces cerevisiae S288C 31-35 10512701-8 1999 Despite limited amino acid sequence homology among HPt domains, our analysis of YPD1 as a prototypical family member, indicates that these phosphotransfer domains are likely to share a similar fold and common features with regard to response regulator binding and mechanism for histidine-aspartate phosphoryl transfer. Histidine 278-287 Ypd1p Saccharomyces cerevisiae S288C 80-84 10508853-2 1999 SPP contains a signature zinc-binding motif, His-X-X-Glu-His, that places it in a metallopeptidase family which includes the mitochondrial processing peptidase. Histidine 45-48 histocompatibility minor 13 Homo sapiens 0-3 10508853-2 1999 SPP contains a signature zinc-binding motif, His-X-X-Glu-His, that places it in a metallopeptidase family which includes the mitochondrial processing peptidase. Histidine 57-60 histocompatibility minor 13 Homo sapiens 0-3 10504263-1 1999 MRE-binding transcription factor-1 (MTF-1) contains six Cys(2)-His(2) zinc finger sequences, and it has been suggested that the zinc finger domain itself may function as a zinc sensor in zinc-activated expression of metallothioneins (MTs). Histidine 63-66 metal regulatory transcription factor 1 Homo sapiens 0-34 10504263-1 1999 MRE-binding transcription factor-1 (MTF-1) contains six Cys(2)-His(2) zinc finger sequences, and it has been suggested that the zinc finger domain itself may function as a zinc sensor in zinc-activated expression of metallothioneins (MTs). Histidine 63-66 metal regulatory transcription factor 1 Homo sapiens 36-41 10473550-1 1999 Zinc increases the affinity of human growth hormone (hGH) for the human prolactin receptor (hPRLR) due to the coordination of one zinc ion involving Glu-174(hGH) and His-18(hGH). Histidine 166-169 prolactin receptor Homo sapiens 72-90 10473550-1 1999 Zinc increases the affinity of human growth hormone (hGH) for the human prolactin receptor (hPRLR) due to the coordination of one zinc ion involving Glu-174(hGH) and His-18(hGH). Histidine 166-169 prolactin receptor Homo sapiens 92-97 10455016-2 1999 Single amino acid mutations in human CYP17, Arg(347)-->His and Arg(358)-->Gln, have been reported to result in the loss of the lyase activity and to cause sexual phenotypic changes in 46XY male patients. Histidine 58-61 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 37-42 10610126-5 1999 It was demonstrated for the first time that the receiver domain in this sensor exhibits a strong phosphohistidine phosphatase activity toward some Arabidopsis HPt phosphotransmitters (AHP1 and AHP2), suggesting the functional importance of the receiver domain for a resumed interaction of the sensor His-kinase with other His-Asp phosphorelay components. Histidine 300-303 histidine-containing phosphotransmitter 1 Arabidopsis thaliana 184-188 10446255-7 1999 Bacterially expressed, purified His-C/EBPalpha is able to disrupt E2F/p107 complexes that are observed at earlier stages of 3T3-L1 differentiation. Histidine 32-35 CCAAT/enhancer binding protein (C/EBP), alpha Mus musculus 36-46 10446255-7 1999 Bacterially expressed, purified His-C/EBPalpha is able to disrupt E2F/p107 complexes that are observed at earlier stages of 3T3-L1 differentiation. Histidine 32-35 RB transcriptional corepressor like 1 Mus musculus 70-74 10417309-9 1999 A histidine residue at position 140 in rat liver CPT I has been indicated to be important for inhibition by malonyl-CoA. Histidine 2-11 carnitine palmitoyltransferase 1B Rattus norvegicus 49-54 10411902-1 1999 Alteration of the FHIT (fragile histidine triad) gene occurs as an early and frequent event in lung carcinogenesis. Histidine 32-41 fragile histidine triad diadenosine triphosphatase Homo sapiens 18-22 10410979-3 1999 Employing this method, a recombinant C3a (rC3a) anaphylatoxin with a His-tag at its N-terminus could be shown to bind to C3a receptor (C3aR)-expressing RBL-2H3 transfectants with a half-maximal effective concentration (EC50) of about 3 nM which is well within the range of published affinity constants. Histidine 69-72 complement C3a receptor 1 Homo sapiens 121-133 10410979-3 1999 Employing this method, a recombinant C3a (rC3a) anaphylatoxin with a His-tag at its N-terminus could be shown to bind to C3a receptor (C3aR)-expressing RBL-2H3 transfectants with a half-maximal effective concentration (EC50) of about 3 nM which is well within the range of published affinity constants. Histidine 69-72 complement C3a receptor 1 Homo sapiens 135-139 10364171-2 1999 Increases of external pH decrease the single-channel conductance in mutant R148H of the Kir2.1 channel (arginine is mutated into histidine) but not in the wild type channel. Histidine 129-138 potassium inwardly rectifying channel subfamily J member 2 Homo sapiens 88-94 10358012-0 1999 Histidine 179 mutants of GTP cyclohydrolase I catalyze the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone triphosphate. Histidine 0-9 GTP cyclohydrolase 1 Homo sapiens 25-45 10224104-5 1999 Mutation of Gln356 (Gln233 in E. coli MetAP) to alanine results in a catalytic efficiency about one-third that of native with normal substrates but which can cleave methionine from substrates with penultimate histidine, asparagine, glutamine, leucine, methionine, phenylalanine, and tryptophan. Histidine 209-218 methionine aminopeptidase Saccharomyces cerevisiae S288C 38-43 10223242-3 1999 Recently, the fragile histidine triad (FHIT) gene, which is frequently lost in many cancers, was identified as a candidate tumor suppressor gene at chromosome 3p locus 14.2. Histidine 22-31 fragile histidine triad diadenosine triphosphatase Homo sapiens 39-43 10220559-8 1999 A histidine residue in the third extracellular loop of Kv1.5 (H452) accounts for the difference in pH sensitivity between the Kv1.5 and Kv1.2 channels. Histidine 2-11 potassium voltage-gated channel subfamily A member 4 L homeolog Xenopus laevis 55-60 10220559-8 1999 A histidine residue in the third extracellular loop of Kv1.5 (H452) accounts for the difference in pH sensitivity between the Kv1.5 and Kv1.2 channels. Histidine 2-11 potassium voltage-gated channel subfamily A member 4 L homeolog Xenopus laevis 126-131 10220559-9 1999 Mutation of histidine H452 to a glutamine residue in Kv1.5 yields a channel that no longer shows enhanced inactivation with acidification. Histidine 12-21 potassium voltage-gated channel subfamily A member 4 L homeolog Xenopus laevis 53-58 10206968-2 1999 Our previous studies identified a pore histidine as a major component of the acid activation mechanism of the potato guard cell K+ channel KST1 (1). Histidine 39-48 solute carrier family 5 member 11 Homo sapiens 139-143 10206968-4 1999 In both channels, KST1 and KAT1, aspartate mutants in the K+ channel consensus sequence GYGD adjacent to the histidine (KST1-D269N and KAT1-D265N) were inhibited by a rise in the extracellular proton concentration. Histidine 109-118 solute carrier family 5 member 11 Homo sapiens 18-22 10206968-4 1999 In both channels, KST1 and KAT1, aspartate mutants in the K+ channel consensus sequence GYGD adjacent to the histidine (KST1-D269N and KAT1-D265N) were inhibited by a rise in the extracellular proton concentration. Histidine 109-118 solute carrier family 5 member 11 Homo sapiens 120-124 10206968-7 1999 From our electrophysiological studies on channel mutants with respect to the pore histidine as well as the aspartate, we conclude that the common proton-supported shift in the voltage dependence of KST1 and KAT1 is based on distinct molecular elements. Histidine 82-91 solute carrier family 5 member 11 Homo sapiens 198-202 11776848-1 1999 OBJECTIVE: To investigate alterations of fragile histidine triad (FHIT) gene and p16 gene in lung cancer. Histidine 49-58 fragile histidine triad diadenosine triphosphatase Homo sapiens 66-70 10050767-6 1999 The parathyroid hormone-related protein(1-34) structure and the structure of human parathyroid hormone(1-37) as well as human parathyroid hormone(1-34) are highly similar, except for the well defined turn, His-14-Ser-17, present in parathyroid hormone. Histidine 206-209 parathyroid hormone like hormone Homo sapiens 4-39 10022949-1 1999 Histidine auxotrophs of wild-type strain I-182 of Candida oleophila, produced using ethyl methanesulfonate, were transformed with plasmids containing the HIS3, HIS4 and HIS5 genes of Saccharomyces cerevisiae. Histidine 0-9 histidinol-phosphate transaminase Saccharomyces cerevisiae S288C 169-173 10022949-2 1999 Histidine auxotrophy was complemented by the HIS5 gene of S. cerevisiae. Histidine 0-9 histidinol-phosphate transaminase Saccharomyces cerevisiae S288C 45-49 9926922-1 1999 Aberrant FHIT mRNA transcripts are present in malignant and normal haematopoiesis, but absence of FHIT protein is restricted to leukaemia Alterations of the recently cloned fragile histidine triad (FHIT) gene at chromosome 3p14.2 are frequent in a variety of solid tumours and cancer cell lines. Histidine 181-190 fragile histidine triad diadenosine triphosphatase Homo sapiens 9-13 10619374-5 1999 The aim of this study was to elucidate whether central injection of substituted GLP-1 in which N-terminal histidine of mammalian GLP-1 (7-36) amide was replaced with tyrosine, inhibits food intake in the chick. Histidine 106-115 glucagon like peptide 1 receptor Homo sapiens 80-85 10619374-5 1999 The aim of this study was to elucidate whether central injection of substituted GLP-1 in which N-terminal histidine of mammalian GLP-1 (7-36) amide was replaced with tyrosine, inhibits food intake in the chick. Histidine 106-115 glucagon like peptide 1 receptor Homo sapiens 129-134 10619374-7 1999 These results indicate that N-terminal histidine of GLP-1 (7-36) amide is important for efficacy, but not essential for its bioactivity. Histidine 39-48 glucagon Gallus gallus 52-57 10447101-2 1999 Replacement of His with Ala resulted in [Ala6]-MT-II with affinity and agonist potency at human MC3, MC4, and MC5 receptors similar to MT-II. Histidine 15-18 melanocortin 3 receptor Homo sapiens 96-99 10604277-2 1999 Biochemical characterization of MMPs, a family of neutral proteolytic enzymes involved in extracellular matrix modeling, included determination of substrate specificity and Ca+2 dependency, as well as the effects of protease inactivators, carboxylic and His (histidine) residue modifiers, and antibiotics. Histidine 259-268 matrix metallopeptidase 2 Homo sapiens 32-36 9857030-7 1998 A chimeric tetramer composed of three ubiquitins and one histidine-tagged NEDD8 binds to the 26 S proteasome with an affinity similar to that of tetraubiquitin. Histidine 57-66 NEDD8 ubiquitin like modifier Homo sapiens 74-79 9830034-2 1998 Under those conditions, the tripartite sensor kinase ArcB undergoes autophosphorylation at the expense of ATP and subsequently transphosphorylates its cognate response regulator ArcA through a His --> Asp --> His --> Asp phosphorelay pathway. Histidine 193-196 arginine deiminase Escherichia coli 178-182 9830034-2 1998 Under those conditions, the tripartite sensor kinase ArcB undergoes autophosphorylation at the expense of ATP and subsequently transphosphorylates its cognate response regulator ArcA through a His --> Asp --> His --> Asp phosphorelay pathway. Histidine 215-218 arginine deiminase Escherichia coli 178-182 9990655-2 1998 To inhibit AT2 receptors we used their selective antagonist CGP 42112A (nicotinic acid-Tyr-N-benzoxyl-carbonyl-Arg-Lys-His-Pro-Ile-OH). Histidine 119-122 angiotensin II receptor, type 2 Rattus norvegicus 11-14 9794789-0 1998 Roles of the N- and C-terminal domains of carnitine palmitoyltransferase I isoforms in malonyl-CoA sensitivity of the enzymes: insights from expression of chimaeric proteins and mutation of conserved histidine residues. Histidine 200-209 carnitine palmitoyltransferase 1B Rattus norvegicus 42-74 9794789-8 1998 Additionally, further weight is added to the notion that one or more histidine residues may be involved in the CPT I-malonyl-CoA interaction. Histidine 69-78 carnitine palmitoyltransferase 1B Rattus norvegicus 111-116 9822821-4 1998 The same combined approach, used to study histidine biosynthesis gene expression, showed that HIS1 and HIS4 expression is co-regulated with purine biosynthesis genes whereas HIS2, HIS3, HIS5 and HIS6 expression is not. Histidine 42-51 ATP phosphoribosyltransferase Saccharomyces cerevisiae S288C 94-98 9751525-4 1998 We used immunocytochemical methods to visualize histamine, histidine decarboxylase (HDC, the enzyme that converts histidine to histamine), and the type 1 vesicular monoamine transporter (VMAT1, the protein responsible for moving histamine into vesicles for storage and release). Histidine 59-68 histidine decarboxylase Rattus norvegicus 84-87 9827668-2 1998 The limited proteolysis of thyrotropin-releasing hormone (TRH) by Pyroglutamate aminopeptidase yields cyclo(His-Pro) or CHP, a new biopeptide associated with a variety of pharmacological activities, including regulation of body temperature, inhibition of prolactin secretion, and modulation of motor functions. Histidine 108-111 thyrotropin releasing hormone Homo sapiens 27-56 9827668-2 1998 The limited proteolysis of thyrotropin-releasing hormone (TRH) by Pyroglutamate aminopeptidase yields cyclo(His-Pro) or CHP, a new biopeptide associated with a variety of pharmacological activities, including regulation of body temperature, inhibition of prolactin secretion, and modulation of motor functions. Histidine 108-111 thyrotropin releasing hormone Homo sapiens 58-61 9733991-3 1998 RcAAP1-mediated histidine uptake was pH dependent with highest transport rates at acidic pH; it was sensitive to protonophores and uncouplers and the Km for histidine uptake was 96 microM. Histidine 16-25 amino acid permease 3 Ricinus communis 0-6 9733991-3 1998 RcAAP1-mediated histidine uptake was pH dependent with highest transport rates at acidic pH; it was sensitive to protonophores and uncouplers and the Km for histidine uptake was 96 microM. Histidine 157-166 amino acid permease 3 Ricinus communis 0-6 9724051-4 1998 Histamine is formed from L-histidine by histidine decarboxylase (HDC). Histidine 25-36 histidine decarboxylase Mus musculus 40-63 9724051-4 1998 Histamine is formed from L-histidine by histidine decarboxylase (HDC). Histidine 25-36 histidine decarboxylase Mus musculus 65-68 9705508-1 1998 Bas1p is a yeast transcription factor that activates expression of purine and histidine biosynthesis genes in response to extracellular purine limitation. Histidine 78-87 Bas1p Saccharomyces cerevisiae S288C 0-5 9718294-5 1998 The mutant with the fewest residues deleted, apo Delta(88-98)A-I(+his), has the least secondary structure (only 34% helix) and is also the least stable (DeltaG = 2.9 kcal/mol). Histidine 66-69 serine peptidase inhibitor, Kunitz type 1 Homo sapiens 61-64 9718294-7 1998 Apo Delta(1-65)A-I(+his) exhibited a discrete species which was less asymmetric (dimensions equal to 9 x 2.9 nm). Histidine 20-23 serine peptidase inhibitor, Kunitz type 1 Homo sapiens 15-18 9718294-11 1998 Apo Delta(1-43)A-I, apo Delta(1-65)A-I(+his), and apo Delta(88-98)A-I(+his) show lipid affinities statistically similar to apo wtA-I(+his), but significantly defective DMPC clearance kinetics. Histidine 40-43 serine peptidase inhibitor, Kunitz type 1 Homo sapiens 35-38 9718294-11 1998 Apo Delta(1-43)A-I, apo Delta(1-65)A-I(+his), and apo Delta(88-98)A-I(+his) show lipid affinities statistically similar to apo wtA-I(+his), but significantly defective DMPC clearance kinetics. Histidine 40-43 serine peptidase inhibitor, Kunitz type 1 Homo sapiens 35-38 9718294-14 1998 Importantly, studies on apo Delta(88-98)A-I(+his) provide the first experimental evidence that a native-like structure is not necessary for native-like lipid affinity, but apparently is necessary for both DMPC solubilization and LCAT activation. Histidine 45-48 serine peptidase inhibitor, Kunitz type 1 Homo sapiens 40-43 9744812-4 1998 The present report may be related to the recent finding that human Fhit (fragile histidine triad) protein, encoded by the FHIT putative tumor suppressor gene, is a typical dinucleoside 5",5""-P1,P3-triphosphate (Ap3A) hydrolase (EC 3.6.1.29). Histidine 81-90 fragile histidine triad diadenosine triphosphatase Homo sapiens 67-71 9744812-4 1998 The present report may be related to the recent finding that human Fhit (fragile histidine triad) protein, encoded by the FHIT putative tumor suppressor gene, is a typical dinucleoside 5",5""-P1,P3-triphosphate (Ap3A) hydrolase (EC 3.6.1.29). Histidine 81-90 fragile histidine triad diadenosine triphosphatase Homo sapiens 122-126 9744812-4 1998 The present report may be related to the recent finding that human Fhit (fragile histidine triad) protein, encoded by the FHIT putative tumor suppressor gene, is a typical dinucleoside 5",5""-P1,P3-triphosphate (Ap3A) hydrolase (EC 3.6.1.29). Histidine 81-90 fragile histidine triad diadenosine triphosphatase Homo sapiens 212-227 9681494-3 1998 Bufo insulin was, however, more potent (4-fold) than human insulin in inhibiting the binding of [125I-Tyr-A14] insulin to the soluble full-length recombinant human insulin receptor, which is probably a consequence of the substitution (Thr --> His) at position A-8. Histidine 246-249 insulin receptor Homo sapiens 164-180 9671501-2 1998 We purified a polyhistidine-tagged form of Prt1p (His-Prt1p) by Ni2+ affinity and gel filtration chromatography and obtained a complex of approximately 600 kDa composed of six polypeptides whose copurification was completely dependent on the polyhistidine tag on His-Prt1p. Histidine 263-266 translation initiation factor eIF3 core subunit b Saccharomyces cerevisiae S288C 43-48 9671501-3 1998 All five polypeptides associated with His-Prt1p were identified by mass spectrometry, and four were found to be the other putative homologs of human eIF3 subunits encoded in S. cerevisiae: YBR079c/Tif32p, Nip1p, Tif34p, and YDR429c/Tif35p. Histidine 38-41 eukaryotic translation initiation factor 3 subunit B Homo sapiens 42-47 9632755-4 1998 Affinity isolation of histidine-tagged Sba1p (Sba1(His6)) after expression in yeast led to coisolation of Hsp90 and the cyclophilin homolog Cpr6. Histidine 22-31 Hsp90 cochaperone SBA1 Saccharomyces cerevisiae S288C 39-44 9632755-4 1998 Affinity isolation of histidine-tagged Sba1p (Sba1(His6)) after expression in yeast led to coisolation of Hsp90 and the cyclophilin homolog Cpr6. Histidine 22-31 Hsp90 cochaperone SBA1 Saccharomyces cerevisiae S288C 39-43 9632755-4 1998 Affinity isolation of histidine-tagged Sba1p (Sba1(His6)) after expression in yeast led to coisolation of Hsp90 and the cyclophilin homolog Cpr6. Histidine 22-31 1-(5-phosphoribosyl)-5- ((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase HIS6 Saccharomyces cerevisiae S288C 51-55 9632755-4 1998 Affinity isolation of histidine-tagged Sba1p (Sba1(His6)) after expression in yeast led to coisolation of Hsp90 and the cyclophilin homolog Cpr6. Histidine 22-31 peptidylprolyl isomerase CPR6 Saccharomyces cerevisiae S288C 140-144 9660202-5 1998 The IC50 of the best peptides is 30 microM which is close to the K(M) (6 microM) of EI for its natural substrate HPr (histidine containing phosphoryl carrier protein of the PTS). Histidine 118-127 haptoglobin-related protein Homo sapiens 113-116 9621287-5 1998 The fragile histidine triad (FHIT) gene is localized at the most common fragile site at chromosome 3p14.2. Histidine 12-21 fragile histidine triad diadenosine triphosphatase Homo sapiens 29-33 9600911-6 1998 Kinetic analysis indicates that a DNA-histidine complex may perform a reaction that is analogous to the first step of the proposed catalytic mechanism of RNase A, in which the imidazole group of histidine serves as a general base catalyst. Histidine 38-47 ribonuclease A family member 1, pancreatic Homo sapiens 154-161 9600911-6 1998 Kinetic analysis indicates that a DNA-histidine complex may perform a reaction that is analogous to the first step of the proposed catalytic mechanism of RNase A, in which the imidazole group of histidine serves as a general base catalyst. Histidine 195-204 ribonuclease A family member 1, pancreatic Homo sapiens 154-161 9636708-7 1998 Cross-linking, co-immunoprecipitation, and histidine tagging experiments showed that YccA11 as well as YccA can associate with both the FtsH and the HflKC proteins. Histidine 43-52 YccA Escherichia coli 85-89 9582326-10 1998 In contrast, complex p38.p37.p36-his displayed no ATPase, suggesting that p40 is essential for ATPase activity. Histidine 33-36 nucleoporin 37 Homo sapiens 25-28 9582326-10 1998 In contrast, complex p38.p37.p36-his displayed no ATPase, suggesting that p40 is essential for ATPase activity. Histidine 33-36 interleukin 9 Homo sapiens 74-77 9582326-11 1998 Although p38 was not required for ATPase activity, the activity of the p40-his.p38.p37. Histidine 75-78 interleukin 9 Homo sapiens 71-74 9582326-11 1998 Although p38 was not required for ATPase activity, the activity of the p40-his.p38.p37. Histidine 75-78 nucleoporin 37 Homo sapiens 83-86 9582326-12 1998 p36 complex was more salt-resistant than that of the p40-his.p37.p36 complex. Histidine 57-60 interleukin 9 Homo sapiens 53-56 9582326-12 1998 p36 complex was more salt-resistant than that of the p40-his.p37.p36 complex. Histidine 57-60 nucleoporin 37 Homo sapiens 61-64 9576908-3 1998 Fhit protein is a diadenosine P1,P3-triphosphate (ApppA) hydrolase whose fungal and animal homologs form a branch of the histidine triad (HIT) superfamily of nucleotide-binding proteins. Histidine 121-130 fragile histidine triad diadenosine triphosphatase Homo sapiens 0-4 9576908-7 1998 The form of Fhit bound to two ApppA substrates would present to the cell a dramatically phosphorylated surface, prominently displaying six phosphate groups and two adenosine moieties in place of a deep cavity lined with histidines, arginines, and glutamines. Histidine 220-230 fragile histidine triad diadenosine triphosphatase Homo sapiens 12-16 9553063-13 1998 SBCRK and histidine-tagged CRK3 activities were inhibited by the purine analogue olomoucine with an IC50 of 28 and 42 microM, respectively, 5-6-fold higher than human p34(cdc2)/cyclinB. Histidine 10-19 cyclin H Homo sapiens 167-170 9600253-8 1998 The invariant PrP residues Tyr-128 and His-177 align with the two presumed active-site residues of signal peptidases and are in close spatial proximity in the three-dimensional structure of PrP(121-231). Histidine 39-42 prion protein Mus musculus 190-193 9537583-2 1998 Recent studies have localized the FHIT (fragile histidine triad) gene in this region and also demonstrated a high frequency of abnormalities of this gene in various cancers. Histidine 48-57 fragile histidine triad diadenosine triphosphatase Homo sapiens 34-38 9546397-3 1998 The 2.6 A crystal structure of HFE reveals the locations of hemochromatosis mutations and a patch of histidines that could be involved in pH-dependent interactions. Histidine 101-111 homeostatic iron regulator Homo sapiens 31-34 9713284-0 1998 Expression of abnormal transcripts of the FHIT (fragile histidine triad) gene in ovarian carcinoma. Histidine 56-65 fragile histidine triad diadenosine triphosphatase Homo sapiens 42-46 9713284-1 1998 To elucidate the role of the FHIT (fragile histidine triad) gene in ovarian carcinogenesis, the expression of the gene was analysed by reverse transcription-polymerase chain reaction (RT-PCR) in 51 cases of ovarian carcinoma, 6 cases of borderline tumour and 4 cases of benign ovarian tumour. Histidine 43-52 fragile histidine triad diadenosine triphosphatase Homo sapiens 29-33 9546316-2 1998 Basophils and mast cells are the main sources of histamine, which is formed from L-histidine by histidine decarboxylase (HDC). Histidine 81-92 histidine decarboxylase Homo sapiens 96-119 9546316-2 1998 Basophils and mast cells are the main sources of histamine, which is formed from L-histidine by histidine decarboxylase (HDC). Histidine 81-92 histidine decarboxylase Homo sapiens 121-124 9546649-8 1998 To compare the general biochemical properties of AATP2 with the known transport properties of AATP1 we cloned the entire AATP2 cDNA into plasmid pJT118, leading to the presence of an additional N-terminal histidine tag of 10 amino acids. Histidine 205-214 AAA-ATPase 1 Arabidopsis thaliana 94-99 9499091-7 1998 In the case of Cys-, Leu-, Asn-, Gln-, or Arg-nsP4, revertants that were indistinguishable in plaque phenotype from the wild-type virus arose by same-site reversion to Tyr, Trp, Phe, or His by a single nucleotide substitution in the original mutant codon. Histidine 186-189 serine protease 57 Homo sapiens 46-50 9461622-8 1998 Moreover, recombinant M1Pase is subject to active site-directed, hydroxylamine-reversible inhibition by the histidine-selective acylating reagent diethyl pyrocarbonate. Histidine 108-117 ETH_00027300 Eimeria tenella 22-28 9461622-9 1998 These results indicate the presence of an essential histidine residue(s) at the M1Pase active site, as predicted for a histidine phosphatase. Histidine 52-61 ETH_00027300 Eimeria tenella 80-86 9425070-0 1998 Conformational fluctuations in deoxy hemoglobin revealed as a major contributor to anionic modulation of function through studies of the oxygenation and oxidation of hemoglobins A0 and Deer Lodge beta2(NA2)His --> Arg. Histidine 206-209 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 196-201 9426066-5 1998 Only two alterations, both at codon 24, have been identified in CDK4: an activating arginine-to-cysteine transition and a germ-line arginine-to-histidine substitution in one French kindred. Histidine 144-153 cyclin dependent kinase 4 Homo sapiens 64-68 10063967-1 1998 In early 1996, the Fragile Histidine Triad or FHIT gene (pronounced FIT) was cloned and shown to straddle the most fragile human chromosome site at chromosome band 3p14.2. Histidine 27-36 fragile histidine triad diadenosine triphosphatase Homo sapiens 46-50 9407045-0 1997 On the formation and reactivity of compound I of the His-64 myoglobin mutants. Histidine 53-56 myoglobin Physeter catodon 60-69 9407045-5 1997 The results unambiguously indicate that His-64 plays a key role in destabilizing wild type Mb-I. Histidine 40-43 myoglobin Physeter catodon 91-95 9398335-3 1997 Sequence comparisons of ACC oxidases with isopenicillin N synthase (IPNS) and members of the 2-oxoglutarate Fe(II) dependent dioxygenases show an aspartate and two of six ACC oxidase conserved histidine residues are completely conserved throughout this subfamily of Fe(II) dependent oxygenases/oxidases. Histidine 193-202 1-aminocyclopropane-1-carboxylate oxidase Solanum lycopersicum 24-35 9461294-0 1997 Three-dimensional solution structure of human angiogenin determined by 1H,15N-NMR spectroscopy--characterization of histidine protonation states and pKa values. Histidine 116-125 angiogenin Homo sapiens 46-56 9435528-4 1997 Enzymatic degradation of TRH in vivo produces other bioactive peptides such as cyclo(His-Pro). Histidine 85-88 thyrotropin releasing hormone Rattus norvegicus 25-28 9435528-5 1997 Because of the short half-life of TRH and the stability of cyclo(His-Pro) in vivo, we postulated that at least part of the peripheral TRH effects on the exocrine pancreatic secretion may be attributed to cyclo(His-Pro), which has been shown to have other biological activities. Histidine 65-68 thyrotropin releasing hormone Rattus norvegicus 134-137 9435528-5 1997 Because of the short half-life of TRH and the stability of cyclo(His-Pro) in vivo, we postulated that at least part of the peripheral TRH effects on the exocrine pancreatic secretion may be attributed to cyclo(His-Pro), which has been shown to have other biological activities. Histidine 210-213 thyrotropin releasing hormone Rattus norvegicus 134-137 9435528-7 1997 TRH and its metabolite cyclo(His-Pro) dose dependently inhibited 2-deoxy-D-glucose (2-DG)-stimulated pancreatic secretion. Histidine 29-32 thyrotropin releasing hormone Rattus norvegicus 0-3 9414234-0 1997 The tautomeric state of histidines in myoglobin. Histidine 24-34 myoglobin Physeter catodon 38-47 9414234-3 1997 Of the nine histidines not interacting with the heme in sperm whale myoglobin, it was found that seven (His-12, His-48, His-81, His-82, His-113, His-116, and His-119) are predominantly in the N epsilon2H form with varying degrees of contribution from the Ndelta1 H form. Histidine 12-22 myoglobin Physeter catodon 68-77 9414234-10 1997 With the experimentally determined tautomeric state composition in solution, it will be possible to broaden the scope of other studies focused on the electrostatic contribution of histidines to the thermodynamic properties of myoglobin. Histidine 180-190 myoglobin Physeter catodon 226-235 9442929-4 1997 The plausible role of histidine residues at the active site of brain adenosine deaminase was proved by chemical modification with (DEP). Histidine 22-31 adenosine deaminase Bos taurus 69-88 9448095-13 1997 Human liver HMW-ZnAP is sensitive to temperatures higher than 40 degrees C. The pH-dependence of the steady-state kinetic parameters indicates the existence of an essential ionizable group with a pKa of 7.25-7.50, similar to that of histidine. Histidine 233-242 cilia and flagella associated protein 97 Homo sapiens 12-15 9401074-1 1997 Recently the FHIT gene (fragile histidine triad gene) has been identified at chromosome 3p14.2 and a high frequency of abnormalities in this gene has been demonstrated in various cancers. Histidine 32-41 fragile histidine triad diadenosine triphosphatase Homo sapiens 13-17 9382895-2 1997 We have mutated Arg148, which is perfectly conserved in all inward rectifiers, to His in the H5 of IRK1 (Kir2. Histidine 82-85 potassium inwardly rectifying channel subfamily J member 2 Homo sapiens 99-103 9367815-4 1997 The ratio of recovery of the pure active recombinant protein was better when the purification of the protein was made easier by addition of a short His-Tag at the C-terminal moiety of AADC, as achieved in the case of pET-20b+ vector expression. Histidine 148-151 dopa decarboxylase Rattus norvegicus 184-188 9367166-0 1997 Effect of chemical glycosylation of RNase A on the protein stability and surface histidines accessibility in immobilized metal ion affinity electrophoresis (IMAGE) system. Histidine 81-91 ribonuclease A family member 1, pancreatic Homo sapiens 36-43 9367166-1 1997 Immobilized metal ion affinity gel electrophoresis (IMAGE) has been applied to study the change of the surface histidines topography of RNase A when chemically glycosylated on exposed carboxylic groups with glucosamine using carbodiimide as cross-linker, under mild conditions. Histidine 111-121 ribonuclease A family member 1, pancreatic Homo sapiens 136-143 9332345-0 1997 Paralogous histidine biosynthetic genes: evolutionary analysis of the Saccharomyces cerevisiae HIS6 and HIS7 genes. Histidine 11-20 1-(5-phosphoribosyl)-5- ((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase HIS6 Saccharomyces cerevisiae S288C 95-99 9332345-0 1997 Paralogous histidine biosynthetic genes: evolutionary analysis of the Saccharomyces cerevisiae HIS6 and HIS7 genes. Histidine 11-20 imidazoleglycerol-phosphate synthase Saccharomyces cerevisiae S288C 104-108 9290961-1 1997 The FHIT (fragile histidine triad) gene has been isolated from the chromosome region 3p14.2, which includes the fragile site locus FRA3B and the breakpoint of the t(3;8) of familial renal carcinoma. Histidine 18-27 fragile histidine triad diadenosine triphosphatase Homo sapiens 4-8 9290961-1 1997 The FHIT (fragile histidine triad) gene has been isolated from the chromosome region 3p14.2, which includes the fragile site locus FRA3B and the breakpoint of the t(3;8) of familial renal carcinoma. Histidine 18-27 fragile histidine triad diadenosine triphosphatase Homo sapiens 131-136 9273895-6 1997 Peptides Boc-His-Pro-Phe-His-Ads-Val-Ile-His-NH2 (VII) having Ads at position 10 had an IC50 of 12 nM against rat renin. Histidine 13-16 renin Rattus norvegicus 114-119 9273895-6 1997 Peptides Boc-His-Pro-Phe-His-Ads-Val-Ile-His-NH2 (VII) having Ads at position 10 had an IC50 of 12 nM against rat renin. Histidine 25-28 renin Rattus norvegicus 114-119 9273895-6 1997 Peptides Boc-His-Pro-Phe-His-Ads-Val-Ile-His-NH2 (VII) having Ads at position 10 had an IC50 of 12 nM against rat renin. Histidine 25-28 renin Rattus norvegicus 114-119 9218460-5 1997 The carboxyl-terminal tetrapeptide His-Asp-Glu-Phe was shown to be responsible for retention of calumenin in ER by the retention assay, immunostaining with a confocal laser microscope, and the deglycosylation assay. Histidine 35-38 calumenin Mus musculus 96-105 9211872-8 1997 PDI/beta polypeptide containing a histidine tag in its N terminus was found to form prolyl 4-hydroxylase tetramers as readily as the wild-type PDI/beta polypeptide, and histidine-tagged forms of prolyl 4-hydroxylase appear to offer an excellent source for a simple large scale purification of the recombinant enzyme. Histidine 34-43 prolyl 4-hydroxylase subunit beta Homo sapiens 0-3 9261067-1 1997 BACKGROUND: The fragile histidine triad (FHIT) protein is a member of the large and ubiquitous histidine triad (HIT) family of proteins. Histidine 24-33 fragile histidine triad diadenosine triphosphatase Homo sapiens 41-45 9261067-1 1997 BACKGROUND: The fragile histidine triad (FHIT) protein is a member of the large and ubiquitous histidine triad (HIT) family of proteins. Histidine 95-104 fragile histidine triad diadenosine triphosphatase Homo sapiens 41-45 9289426-7 1997 This mechanism involves GCN4-independent activation of expression of genes of purine and histidine metabolism. Histidine 89-98 amino acid starvation-responsive transcription factor GCN4 Saccharomyces cerevisiae S288C 24-28 9225464-5 1997 A repeated domain was identified within the predicted 3AF1 amino acid sequence, which includes a series of histidines and cysteines, suggestive of zinc binding, and this repeat is conserved in E4/E8BP-1. Histidine 107-117 peptide methionine sulfoxide reductase Solanum lycopersicum 193-200 9194196-2 1997 Recombinant human URO-D has been expressed in Escherichia coli with a histidine tag and has been purified to homogeneity. Histidine 70-79 uroporphyrinogen decarboxylase Homo sapiens 18-23 9194196-5 1997 URO-D containing an amino-terminal histidine tag was crystallized in space group P3(1)21 or its enantiomer P3(2)21 with unit cell dimensions a = b = 103.6 A, c = 75.2 A. Histidine 35-44 uroporphyrinogen decarboxylase Homo sapiens 0-5 9148890-8 1997 A mutant JEM1p carrying a mutation in the highly conserved His-Pro-Asp sequence in the J-domain could not complement either temperature-sensitive growth of the Deltajem1 Deltascj1 double mutant or defects in karyogamy of the Deltajem1 mutant. Histidine 59-62 Jem1p Saccharomyces cerevisiae S288C 9-14 9115288-3 1997 Site-directed mutagenesis indicated that a number of residues including arginine 19, cysteine 122, histidine 126, glutamic acid 152, arginine 155, and methionine 167 were needed for protection of SSAT by BE-3-4-3. Histidine 99-108 spermidine/spermine N1-acetyltransferase 1 Homo sapiens 196-200 9169852-3 1997 Sequencing of the three pag-3 alleles showed that two apparent null alleles encode a nonsense mutation before the zinc fingers and a missense mutation in the fourth zinc finger that changes a coordinating histidine to a tyrosine. Histidine 205-214 Uncharacterized protein Caenorhabditis elegans 24-29 9125392-2 1997 The (human) MBP epitope for MS anti-MBP is: Pro85-Val-Val-His-Phe-Phe-Lys-Asn-Ile-Val-Thr-Pro96. Histidine 58-61 myelin basic protein Homo sapiens 12-15 9125392-2 1997 The (human) MBP epitope for MS anti-MBP is: Pro85-Val-Val-His-Phe-Phe-Lys-Asn-Ile-Val-Thr-Pro96. Histidine 58-61 myelin basic protein Homo sapiens 36-39 9175718-5 1997 Inactivation of glutathione reductase by alpha,beta-unsaturated aldehydes was followed by slower NADPH-independent reactions that led to formation of nonfluorescent cross-linked products, accompanied by loss of lysine and histidine residues. Histidine 222-231 glutathione-disulfide reductase Homo sapiens 16-37 9045649-4 1997 Functional recombinant RF-C containing p40-his, p37-his, or p36-his was isolated using affinity resin. Histidine 43-46 interleukin 9 Homo sapiens 39-42 9137418-9 1997 The hMSH2 human mismatch repair protein linked to the hereditary nonpolyposis colon cancer gene, has a weak nuclear signal containing two histidines. Histidine 138-148 mutS homolog 2 Homo sapiens 4-9 18475765-1 1997 The interaction of the dinucleotides d(ApG) and d(ApA) with [Pd(aa)Cl(2)], where aa = L- or D-histidine or the methyl ester of L-histidine, and with [Pt(Met)Cl(2)], where Met = L-methionine was studied by (1)H and (13)C NMR and CD measurements. Histidine 127-138 glutamyl aminopeptidase Homo sapiens 50-53 18475765-3 1997 The reaction of L-histidine with d(ApA) seemed to form the bimetallic adduct (L-His)PdN7(1)N7(2)Pd(L-His). Histidine 16-27 glutamyl aminopeptidase Homo sapiens 35-38 18475765-3 1997 The reaction of L-histidine with d(ApA) seemed to form the bimetallic adduct (L-His)PdN7(1)N7(2)Pd(L-His). Histidine 78-83 glutamyl aminopeptidase Homo sapiens 35-38 18475765-3 1997 The reaction of L-histidine with d(ApA) seemed to form the bimetallic adduct (L-His)PdN7(1)N7(2)Pd(L-His). Histidine 99-104 glutamyl aminopeptidase Homo sapiens 35-38 8972223-5 1997 In the C terminus of the IGF-I receptor, two mutations, one at tyrosine 1251 and one which replaced residues histidine 1293 and lysine 1294, abolished the antiapoptotic function, whereas mutation of the four serines at 1280 to 1283 did not. Histidine 109-118 insulin-like growth factor 1 receptor Rattus norvegicus 25-39 9238644-3 1997 The histidine-epsilon-amino caproic acid-beta-alanine-histidine (His-epsilon Ahx-beta Ala-His) sequence was found to yield optimal inhibition of both MMP-2 and MMP-9. Histidine 65-68 matrix metallopeptidase 2 Homo sapiens 150-155 9170214-1 1997 The FHIT (fragile histidine triad) gene on chromosome 3p14 is a candidate tumor suppressor gene, and its transcripts are shown to be abnormal in several human cancers. Histidine 18-27 fragile histidine triad diadenosine triphosphatase Homo sapiens 4-8 9016654-3 1996 TIF1 beta, TIF1 alpha, PML and efp belong to a characteristic subgroup of RING finger proteins that contain one or two other Cys/His-rich clusters (B boxes) and a putative coiled-coil in addition to the classical C3HC4 RING finger motif (RBCC configuration). Histidine 129-132 tripartite motif containing 25 Homo sapiens 31-34 8816462-14 1996 Mutations in the cysteine- and histidine-rich region of Upf1p abolish Upf1p-Upf2p interaction. Histidine 31-40 Nmd2p Saccharomyces cerevisiae S288C 76-81 8841182-2 1996 We now report that an Arg-His substitution at residue 117 of the cationic trypsinogen gene is associated with the HP phenotype. Histidine 26-29 serine protease 1 Homo sapiens 65-85 8863827-6 1996 Induction of a pheromone-responsive FUS1-HIS3 reporter gene in far1 his3 cells permits cell growth in medium lacking histidine. Histidine 117-126 Fus1p Saccharomyces cerevisiae S288C 36-40 8848048-5 1996 Binding occurs between the first cysteine-histidine-rich region of p300/CBP and the carboxy-terminal segment of Stat2, a domain essential for ISGF3 function. Histidine 42-51 E1A binding protein p300 Homo sapiens 67-75 8816823-5 1996 Tunicate GnRH-I (pGlu-His-Trp-Ser-Asp-Tyr-Phe-Lys-Pro-Gly-NH2) has 60% of its residues conserved, compared with mammalian GnRH, whereas tunicate GnRH-II (pGlu-His-Trp-Ser-Leu-Cys-His-Ala-Pro-Gly-NH2) is unusual in that it was isolated as a disulfide-linked dimer. Histidine 22-25 gonadotropin releasing hormone 1 Homo sapiens 9-13 8816823-5 1996 Tunicate GnRH-I (pGlu-His-Trp-Ser-Asp-Tyr-Phe-Lys-Pro-Gly-NH2) has 60% of its residues conserved, compared with mammalian GnRH, whereas tunicate GnRH-II (pGlu-His-Trp-Ser-Leu-Cys-His-Ala-Pro-Gly-NH2) is unusual in that it was isolated as a disulfide-linked dimer. Histidine 22-25 gonadotropin releasing hormone 2 Homo sapiens 145-152 8816823-5 1996 Tunicate GnRH-I (pGlu-His-Trp-Ser-Asp-Tyr-Phe-Lys-Pro-Gly-NH2) has 60% of its residues conserved, compared with mammalian GnRH, whereas tunicate GnRH-II (pGlu-His-Trp-Ser-Leu-Cys-His-Ala-Pro-Gly-NH2) is unusual in that it was isolated as a disulfide-linked dimer. Histidine 159-162 gonadotropin releasing hormone 1 Homo sapiens 9-13 8816823-5 1996 Tunicate GnRH-I (pGlu-His-Trp-Ser-Asp-Tyr-Phe-Lys-Pro-Gly-NH2) has 60% of its residues conserved, compared with mammalian GnRH, whereas tunicate GnRH-II (pGlu-His-Trp-Ser-Leu-Cys-His-Ala-Pro-Gly-NH2) is unusual in that it was isolated as a disulfide-linked dimer. Histidine 159-162 gonadotropin releasing hormone 1 Homo sapiens 9-13 8798433-4 1996 The murine Cux-2 homeobox was similar to Drosophila cut and encoded a homeodomain that contained a characteristic histidine residue at position 50. Histidine 114-123 cut Drosophila melanogaster 52-55 8794732-6 1996 Site-directed mutagenesis of FHIT demonstrated that all four conserved histidines are required for full activity, and the central histidine of the triad is absolutely essential for Ap3A hydrolase activity. Histidine 71-81 fragile histidine triad diadenosine triphosphatase Homo sapiens 29-33 8794732-6 1996 Site-directed mutagenesis of FHIT demonstrated that all four conserved histidines are required for full activity, and the central histidine of the triad is absolutely essential for Ap3A hydrolase activity. Histidine 71-80 fragile histidine triad diadenosine triphosphatase Homo sapiens 29-33 8794732-8 1996 Also, Fhit is the first HIT protein in which the histidine residues have been demonstrated by mutagenesis to be critical for function. Histidine 49-58 fragile histidine triad diadenosine triphosphatase Homo sapiens 6-10 8809067-11 1996 G beta phosphorylation was confirmed by immunoprecipitation with G beta-specific antibodies, and the target amino acid was identified as histidine. Histidine 137-146 succinate-CoA ligase GDP-forming subunit beta Homo sapiens 0-6 8872162-9 1996 Another point mutation in the CDR2 region of BV17S1, which results in the amino acid replacement of Gln by His, originally identified form a cDNA clone, has now been confirmed as an allele by ARMS analysis using genomic DNA preparations and designated to as BV17S1*3. Histidine 107-110 cerebellar degeneration related protein 2 Homo sapiens 30-34 8663175-5 1996 Furthermore, the AT2 receptor agonist N-alpha-nicotinoyl-Tyr-Lys-(N-alphaCBZ-Arg)-His-Pro-Ile-OH (CGP42112A) (10-50 nM) caused significant decreases in neuronal Erk1 and Erk2 activities, which were abolished by PD 123319 (1 microM) and by the PP2A inhibitor okadaic acid (3 nM). Histidine 82-85 angiotensin II receptor, type 2 Rattus norvegicus 17-20 8663175-5 1996 Furthermore, the AT2 receptor agonist N-alpha-nicotinoyl-Tyr-Lys-(N-alphaCBZ-Arg)-His-Pro-Ile-OH (CGP42112A) (10-50 nM) caused significant decreases in neuronal Erk1 and Erk2 activities, which were abolished by PD 123319 (1 microM) and by the PP2A inhibitor okadaic acid (3 nM). Histidine 82-85 mitogen activated protein kinase 3 Rattus norvegicus 161-165 8663175-5 1996 Furthermore, the AT2 receptor agonist N-alpha-nicotinoyl-Tyr-Lys-(N-alphaCBZ-Arg)-His-Pro-Ile-OH (CGP42112A) (10-50 nM) caused significant decreases in neuronal Erk1 and Erk2 activities, which were abolished by PD 123319 (1 microM) and by the PP2A inhibitor okadaic acid (3 nM). Histidine 82-85 mitogen activated protein kinase 1 Rattus norvegicus 170-174 8672465-8 1996 One interaction is between the aromatic ring of Tyr 282 of TM-6 and His of TRH. Histidine 68-71 thyrotropin releasing hormone Homo sapiens 75-78 8538770-5 1996 The histidine at position 1,106(aspartic acid in C4A) first attacks the thioester to form an acyl-imidazole intermediate. Histidine 4-13 complement C4A (Rodgers blood group) Homo sapiens 49-52 7838710-6 1994 The results of the experiments using bacterially expressed MSSP-2, and its deletion mutants, as histidine fusion proteins suggested that the binding specificity of MSSP-2 to double- and single-stranded DNA is the same as that of MSSP-1, and that the RNP consensus sequences are required for the DNA binding of the protein. Histidine 96-105 RNA binding motif single stranded interacting protein 1 pseudogene 1 Homo sapiens 229-235 7947682-10 1994 A similar experiment using the His-specific reagent diethyl pyrocarbonate indicates that one of the six Fbp-encoded His residues is protected by iron. Histidine 31-34 folate receptor beta Homo sapiens 104-107 7947682-10 1994 A similar experiment using the His-specific reagent diethyl pyrocarbonate indicates that one of the six Fbp-encoded His residues is protected by iron. Histidine 116-119 folate receptor beta Homo sapiens 104-107 7957084-5 1994 This newly identified histidine in ArcB and BarA was demonstrated to play a crucial role in the observed multicopy suppression. Histidine 22-31 hypothetical protein Escherichia coli 35-39 7957084-6 1994 Furthermore, it was demonstrated in vivo and in vitro for ArcB that the C-terminal domain containing the histidine can function as an alternative phosphodonor (or transmitter). Histidine 105-114 hypothetical protein Escherichia coli 58-62 7535613-6 1994 In the resulting PSA structure, the catalytic triad, involving residues His 57, Asp 102, and Ser 195, and hydrophobic and electrostatic interactions typical of serine proteases were extremely well conserved. Histidine 72-75 kallikrein related peptidase 3 Homo sapiens 17-20 7925571-7 1994 The pH dependence of IgG1 or Fc fragment binding to FcRn is consistent with the localization of the FcRn interaction site to a region of the Fc that encompasses two histidine residues (His 310 and His 433). Histidine 165-174 Fc fragment of IgG receptor and transporter Mus musculus 52-56 7925571-7 1994 The pH dependence of IgG1 or Fc fragment binding to FcRn is consistent with the localization of the FcRn interaction site to a region of the Fc that encompasses two histidine residues (His 310 and His 433). Histidine 165-174 Fc fragment of IgG receptor and transporter Mus musculus 100-104 7925571-7 1994 The pH dependence of IgG1 or Fc fragment binding to FcRn is consistent with the localization of the FcRn interaction site to a region of the Fc that encompasses two histidine residues (His 310 and His 433). Histidine 185-188 Fc fragment of IgG receptor and transporter Mus musculus 52-56 7925571-7 1994 The pH dependence of IgG1 or Fc fragment binding to FcRn is consistent with the localization of the FcRn interaction site to a region of the Fc that encompasses two histidine residues (His 310 and His 433). Histidine 185-188 Fc fragment of IgG receptor and transporter Mus musculus 100-104 7925571-7 1994 The pH dependence of IgG1 or Fc fragment binding to FcRn is consistent with the localization of the FcRn interaction site to a region of the Fc that encompasses two histidine residues (His 310 and His 433). Histidine 197-200 Fc fragment of IgG receptor and transporter Mus musculus 52-56 7925571-7 1994 The pH dependence of IgG1 or Fc fragment binding to FcRn is consistent with the localization of the FcRn interaction site to a region of the Fc that encompasses two histidine residues (His 310 and His 433). Histidine 197-200 Fc fragment of IgG receptor and transporter Mus musculus 100-104 7522258-3 1994 The analysis indicated that residues 144 (tryptophan) and 147 (histidine) were the TCR binding sites and that residues 145 (leucine) and 148 (proline) were important for MHC class II (IAs) binding. Histidine 63-72 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 83-86 8091132-2 1994 An exchange of phe195 with a tyrosine residue does not affect Tcr/CD3 membrane expression; however, exchange with aspartic acid, histidine or valine prohibit completely Tcr/CD3 membrane expression. Histidine 129-138 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 169-172 7520873-4 1994 It has been assessed by comparison with 1H NMR data on the ionization behaviour of the six histidine residues in LIF, the imidazolium pKa values of which range from 3.6 to 7.4. Histidine 91-100 LIF interleukin 6 family cytokine Homo sapiens 113-116 7515969-0 1994 The Cys-His motif of Ty3 NC can be contributed by Gag3 or Gag3-Pol3 polyproteins. Histidine 8-11 Mdv1p Saccharomyces cerevisiae S288C 50-54 7515969-0 1994 The Cys-His motif of Ty3 NC can be contributed by Gag3 or Gag3-Pol3 polyproteins. Histidine 8-11 Mdv1p Saccharomyces cerevisiae S288C 58-62 7920705-8 1994 A modified SUC1-His6 cDNA encoding a histidine tag at the SUC1 C-terminus was also expressed in S. cerevisiae. Histidine 37-46 sucrose-proton symporter 1 Arabidopsis thaliana 11-15 7920705-8 1994 A modified SUC1-His6 cDNA encoding a histidine tag at the SUC1 C-terminus was also expressed in S. cerevisiae. Histidine 37-46 sucrose-proton symporter 1 Arabidopsis thaliana 58-62 8011627-0 1994 Electron-nuclear coupling to the proximal histidine in oxy cobalt-substituted distal histidine mutants of human myoglobin. Histidine 42-51 myoglobin Homo sapiens 112-121 8011627-0 1994 Electron-nuclear coupling to the proximal histidine in oxy cobalt-substituted distal histidine mutants of human myoglobin. Histidine 85-94 myoglobin Homo sapiens 112-121 8204626-2 1994 Under typical denaturing conditions (concentrated guanidine hydrochloride or urea near pH 7), one of the axial ligands, His 18, remains bound to the oxidized heme iron, but the second ligand, Met 80, is replaced by a non-native histidine ligand (His 26 or His 33 in horse cytochrome c). Histidine 120-123 cytochrome c, somatic Equus caballus 272-284 8204626-5 1994 Heme absorbance changes induced by rapid acidification of oxidized cytochrome c in 4.5 M guanidine hydrochloride from pH 7.8 to 4.6 or below exhibit two kinetic phases with rates of 110 and 25 s-1, attributed to the dissociation of non-native histidine ligands from the heme in the unfolded state. Histidine 243-252 cytochrome c, somatic Equus caballus 67-79 8074930-3 1994 GST fusion proteins can be purified on immobilized glutathione and proteins coupled to the His tag selectively bind to Ni(2+)-NTA columns. Histidine 91-94 hematopoietic prostaglandin D synthase Mus musculus 0-3 8074930-9 1994 Multivalent SMAA complexes were made that contained His-p17-Pk, His-p27-Pk, His-rt-Pk, His-vpx-Pk, and His-vpr-Pk. Histidine 64-67 dynactin 6 Mus musculus 68-71 8074930-9 1994 Multivalent SMAA complexes were made that contained His-p17-Pk, His-p27-Pk, His-rt-Pk, His-vpx-Pk, and His-vpr-Pk. Histidine 64-67 dynactin 6 Mus musculus 68-71 8074930-9 1994 Multivalent SMAA complexes were made that contained His-p17-Pk, His-p27-Pk, His-rt-Pk, His-vpx-Pk, and His-vpr-Pk. Histidine 64-67 dynactin 6 Mus musculus 68-71 8074930-9 1994 Multivalent SMAA complexes were made that contained His-p17-Pk, His-p27-Pk, His-rt-Pk, His-vpx-Pk, and His-vpr-Pk. Histidine 64-67 dynactin 6 Mus musculus 68-71 8208612-5 1994 HEPR does not contain the carboxyl-terminus leucine zipper motif identified in REPR but contains consensus phosphorylation sites as well as the conserved histidine and both cysteine residues identified as a Zn2+ binding motif in other cytidine deaminases. Histidine 154-163 apolipoprotein B mRNA editing enzyme catalytic subunit 1 Homo sapiens 0-4 8087556-11 1994 CONCLUSION: The structure of Candida antarctica lipase B shows that the enzyme has a Ser-His-Asp catalytic triad in its active site. Histidine 89-92 PAN0_003d1715 Moesziomyces antarcticus 48-54 8155728-4 1994 The fact that butyrate ester has the optimum acyl-chain length to be a substrate of LPL can be attributed to its chain length being long enough for optimum interaction with the active site His-Ser-Asp triad in forming the transition state complex; yet it is short enough to provide freedom for optimum positioning of the ester bond for transition state complex formation. Histidine 189-192 lipoprotein lipase Homo sapiens 84-87 8198697-3 1994 Based on the histidine-hexapeptide moiety, the recombinant CENP-B was purified to homogeneity by single-step affinity chromatography using metal chelating matrix. Histidine 13-22 centromere protein B Homo sapiens 59-65 8169525-2 1994 A single base pair substitution of a guanine for cytosine in codon 183 of exon 5 of the LPL gene results in a change of histidine to glutamine in the mature enzyme protein. Histidine 120-129 lipoprotein lipase Homo sapiens 88-91 8278375-0 1994 Histidine-367 of the human common beta chain of the receptor is critical for high-affinity binding of human granulocyte-macrophage colony-stimulating factor. Histidine 0-9 colony stimulating factor 2 Homo sapiens 108-156 8298023-1 1993 The causes of the strong coupling of the iron-histidine vibration to the Soret resonance in the resonance Raman spectra of deoxyhemoglobin, myoglobin, and peroxidase are explored, using the vibronic theory. Histidine 46-55 myoglobin Homo sapiens 140-149 8400292-1 1993 Heterozygosity for a G-->C mutation converting the highly conserved Gln184 (CAG) to His (CAC) was identified at the last nucleotide of exon 7 of the protein C gene in two family members with deep vein thrombosis. Histidine 84-87 protein C, inactivator of coagulation factors Va and VIIIa Homo sapiens 149-158 7804366-4 1993 The data showed that a single amino acid substitution of tyrosine by phenylalanine and a number of amino acids including serine, asparagine, histidine and arginine at position 97 in the VH CDR3 region all resulted in approximate 18-fold lower binding affinity, whereas the substitution of tyrosine by phenylalanine at position 96 in the VH CDR3 region did not affect the binding affinity of the cB72.3m4 antibody. Histidine 141-150 cerebellar degeneration-related 3 Mus musculus 189-193 8397193-2 1993 Tetrazole-myoglobin (Tet-Mb), a site selectively modified myoglobin with tetrazole anion (-CN4-) covalently attached to the imidazole N epsilon of the distal histidine 64(E7) (see Fig. Histidine 158-167 myoglobin Homo sapiens 10-19 8234904-9 1993 Hedgehog PP exhibits only 2 unique amino acid substitutions, at positions 1 (Val) and 19 (His), when compared with other mammalian analogues. Histidine 90-93 pancreatic prohormone Erinaceus europaeus 9-11 8373184-0 1993 Role of the highly conserved histidine residues in rat liver mitochondrial aldehyde dehydrogenase as studied by site-directed mutagenesis. Histidine 29-38 aldehyde dehydrogenase 2 family member Rattus norvegicus 61-97 8373184-1 1993 One histidine residue (H235) is conserved in all known aldehyde dehydrogenases (ALDH), from Escherichia coli to human, except for those from P. oleovorans and rat hepatoma. Histidine 4-13 aldehyde dehydrogenase 2 family member Rattus norvegicus 80-84 8373184-3 1993 Using site-directed mutagenesis, the four conserved histidine residues of the six histidines in rat liver mitochondrial ALDH were converted to alanines. Histidine 52-61 aldehyde dehydrogenase 2 family member Rattus norvegicus 120-124 8373184-3 1993 Using site-directed mutagenesis, the four conserved histidine residues of the six histidines in rat liver mitochondrial ALDH were converted to alanines. Histidine 82-92 aldehyde dehydrogenase 2 family member Rattus norvegicus 120-124 8373184-13 1993 Instead, both H29 and H235 may be of structural importance and the presence of a histidine residue at position 235 may be required for the newly synthesized peptide to fold and/or assemble into the native conformation of ALDH. Histidine 81-90 aldehyde dehydrogenase 2 family member Rattus norvegicus 221-225 8102366-0 1993 Identification of serine 624, aspartic acid 702, and histidine 734 as the catalytic triad residues of mouse dipeptidyl-peptidase IV (CD26). Histidine 53-62 dipeptidylpeptidase 4 Mus musculus 108-131 8102366-0 1993 Identification of serine 624, aspartic acid 702, and histidine 734 as the catalytic triad residues of mouse dipeptidyl-peptidase IV (CD26). Histidine 53-62 dipeptidylpeptidase 4 Mus musculus 133-137 8343114-1 1993 Reaction of human GSH transferase P1-1 (GSTP1-1) with diethylpyrocarbonate (DEPC) at pH 7.0 and 4 degrees C resulted in covalent modification of an equivalent of one histidine and one tyrosine residue per subunit, with loss of activity. Histidine 166-175 glutathione S-transferase pi 1 Homo sapiens 40-47 8332461-8 1993 EF-Gmt differs from its cytoplasmic homolog, EF-2, in that it contains an aspartic acid residue at amino acid position 621 which corresponds to the EF-2 histidine residue at position 715. Histidine 153-162 G elongation factor, mitochondrial 1 Rattus norvegicus 0-6 8332461-9 1993 Since this histidine residue, following posttranslational modification into diphthamide, appears to be the sole cellular target of diphtheria toxin and Pseudomonas aeruginosa endotoxin A, we conclude that EF-Gmt will not be inactivated by these toxins. Histidine 11-20 G elongation factor, mitochondrial 1 Rattus norvegicus 205-211 8385134-4 1993 Putative iron-binding sites of phenylalanine hydroxylase were studied by mutating either histidine 284 or 289 to serine and expressing these mutant enzymes (PAH-H284S and PAH-H289S) in Sf9 cells. Histidine 89-98 phenylalanine hydroxylase Rattus norvegicus 31-56 7682215-4 1993 The association constant of 15-carboxymethylated histidine lysozyme (15CM lysozyme) with the immobilized Fab fragment was smaller by one-seventh than that of 15-carboxamidated histidine lysozyme, though the side chains introduced were almost identical in size. Histidine 49-58 FA complementation group B Homo sapiens 105-108 7682215-4 1993 The association constant of 15-carboxymethylated histidine lysozyme (15CM lysozyme) with the immobilized Fab fragment was smaller by one-seventh than that of 15-carboxamidated histidine lysozyme, though the side chains introduced were almost identical in size. Histidine 176-185 FA complementation group B Homo sapiens 105-108 8432848-4 1993 The mAb had nearly identical VH gene sequences; H8 differed from H238 and H161 by a single nucleotide in FR1 that resulted in a histidine for glutamine substitution. Histidine 128-137 aldo-keto reductase family 1, member B8 Mus musculus 105-108 7916704-5 1993 Specifically, the aa sequence surrounding the proximal His residue, probably essential for TPO activity, is well conserved among these four organisms. Histidine 55-58 thyroid peroxidase Mus musculus 91-94 8380334-0 1993 Roles of proximal ligand in heme proteins: replacement of proximal histidine of human myoglobin with cysteine and tyrosine by site-directed mutagenesis as models for P-450, chloroperoxidase, and catalase. Histidine 67-76 myoglobin Homo sapiens 86-95 8380334-1 1993 Histidine-93(F8) in human myoglobin (Mb), which is the proximal ligand of the heme iron, has been replaced with cysteine or tyrosine by site-directed mutagenesis. Histidine 0-9 myoglobin Homo sapiens 26-35 8433973-1 1993 Dihydrofolate reductase mutants with amino acid replacements in the active center (Thr35-->Asp mutant, Arg57-->His mutant and the mutant with triple replacement Thr35-->Asp, Asn37-->Ser, Arg57-->His) were obtained by site-directed mutagenesis. Histidine 210-213 dihydrofolate reductase Homo sapiens 0-23 1295893-0 1992 Modification of pig liver dimeric dihydrodiol dehydrogenase with diethylpyrocarbonate and by rose bengal-sensitized photooxidation: evidence for an active-site histidine residue. Histidine 160-169 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Sus scrofa 26-59 1400571-3 1992 Deletion of the carboxyl-terminal Leu-Leu-His-Val residues of the 163 amino acid cytoplasmic tail of the bovine Man-6-P/IGF-II receptor partially impaired this function, resulting in the diversion of a portion of the receptor-ligand complexes to the cell surface, where they were endocytosed. Histidine 42-45 insulin like growth factor 2 receptor Homo sapiens 120-135 1517238-0 1992 Identification of essential histidine residues in rat type I iodothyronine deiodinase. Histidine 28-37 iodothyronine deiodinase 1 Rattus norvegicus 54-85 1512262-5 1992 In the R-state, His-97 beta 2 is positioned between Thr-38 alpha 1 and Thr-41 alpha 1, whereas in transition to the T-state His 97 beta 2 must "jump" a turn in the alpha 1 C helix to form nonpolar contacts with Thr-41 alpha 1 and Pro-44 alpha 1. Histidine 16-19 adrenoceptor alpha 1D Homo sapiens 59-66 1512262-5 1992 In the R-state, His-97 beta 2 is positioned between Thr-38 alpha 1 and Thr-41 alpha 1, whereas in transition to the T-state His 97 beta 2 must "jump" a turn in the alpha 1 C helix to form nonpolar contacts with Thr-41 alpha 1 and Pro-44 alpha 1. Histidine 16-19 adrenoceptor alpha 1D Homo sapiens 78-85 1512262-5 1992 In the R-state, His-97 beta 2 is positioned between Thr-38 alpha 1 and Thr-41 alpha 1, whereas in transition to the T-state His 97 beta 2 must "jump" a turn in the alpha 1 C helix to form nonpolar contacts with Thr-41 alpha 1 and Pro-44 alpha 1. Histidine 16-19 adrenoceptor alpha 1D Homo sapiens 78-85 1512262-5 1992 In the R-state, His-97 beta 2 is positioned between Thr-38 alpha 1 and Thr-41 alpha 1, whereas in transition to the T-state His 97 beta 2 must "jump" a turn in the alpha 1 C helix to form nonpolar contacts with Thr-41 alpha 1 and Pro-44 alpha 1. Histidine 16-19 adrenoceptor alpha 1D Homo sapiens 78-85 1512262-5 1992 In the R-state, His-97 beta 2 is positioned between Thr-38 alpha 1 and Thr-41 alpha 1, whereas in transition to the T-state His 97 beta 2 must "jump" a turn in the alpha 1 C helix to form nonpolar contacts with Thr-41 alpha 1 and Pro-44 alpha 1. Histidine 16-19 adrenoceptor alpha 1D Homo sapiens 78-85 1512262-7 1992 In the R2-state, His-97 beta 2 simply rotates away from threonines 38 alpha 1 and 41 alpha 1, breaking contact with these residues and allowing water access to the center of the alpha 1 beta 2 interface. Histidine 17-20 adrenoceptor alpha 1D Homo sapiens 70-92 1512262-7 1992 In the R2-state, His-97 beta 2 simply rotates away from threonines 38 alpha 1 and 41 alpha 1, breaking contact with these residues and allowing water access to the center of the alpha 1 beta 2 interface. Histidine 17-20 adrenoceptor alpha 1D Homo sapiens 70-77 1584790-8 1992 Although other possibilities are not excluded, it is suggested that the modification of histidine residues in proteins by HNE involves a Michael-type addition of the imidazole nitrogen atom of histidine to the alpha, beta-unsaturated bond of HNE, followed by secondary reaction involving the aldehyde group with the C-4 hydroxyl group of HNE. Histidine 88-97 complement C4A (Rodgers blood group) Homo sapiens 316-319 1584790-8 1992 Although other possibilities are not excluded, it is suggested that the modification of histidine residues in proteins by HNE involves a Michael-type addition of the imidazole nitrogen atom of histidine to the alpha, beta-unsaturated bond of HNE, followed by secondary reaction involving the aldehyde group with the C-4 hydroxyl group of HNE. Histidine 193-202 complement C4A (Rodgers blood group) Homo sapiens 316-319 1577716-2 1992 Recent studies have shown that a protein-bound heme adduct formed from the reaction of BrCCl3 with myoglobin was due to bonding of the proximal histidine residue through the ring I vinyl of a heme-CCl2 moiety. Histidine 144-153 C-C motif chemokine ligand 2 Homo sapiens 197-201 1353910-1 1992 The histidine residue at position 715 of elongation factor 2 (EF-2) is posttranslationally modified in a series of enzymatic reactions to 2-[3-carboxyamido-3-(trimethylammonio)-propyl]histidine, which has been given the trivial name diphthamide. Histidine 4-13 eukaryotic translation elongation factor 2 Homo sapiens 41-60 1543499-0 1992 Multi-functional roles of a histidine residue in human pancreatic alpha-amylase. Histidine 28-37 amylase alpha 2A Homo sapiens 55-79 1543499-1 1992 Functional roles of histidine residues at the active site in human pancreatic alpha-amylase were examined by protein engineering. Histidine 20-29 amylase alpha 2A Homo sapiens 67-91 1370813-9 1992 Structural comparison of serine proteases (i.e. acyl-amino acid hydrolase or prolyl endopeptidase) with the most conserved domain of THAM identified a stretch of 200 amino acids containing a putative catalytic triad arranged in a novel topological order (Ser-624, Asp-702, and His-734) thereby defining a subfamily of nonclassical serine proteases. Histidine 277-280 dipeptidylpeptidase 4 Mus musculus 133-137 1616501-4 1992 The pKEA = 6.5 suggests that histidine is in active site of DAO. Histidine 29-38 D-amino acid oxidase Homo sapiens 60-63 1346133-7 1992 Furthermore, we identify a single histidine residue in the alpha 1 variant, replaced by an arginine in alpha 6, as a major determinant for high affinity binding of BZ agonists. Histidine 34-43 adrenoceptor alpha 1D Homo sapiens 59-66 1346133-9 1992 Hence, this histidine present in the alpha 1, alpha 2, alpha 3, and alpha 5 subunits appears to be a key residue for the action of clinically used BZ ligands. Histidine 12-21 adrenoceptor alpha 1D Homo sapiens 37-44 1552831-1 1992 The synthetic hexapeptide, His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 (GHRP, Growth Hormone-Releasing Peptide), has no structural similarities with any of the GH-releasing peptides known and its action in releasing GH is by a complementary but yet not clearly defined action on the pituitary as well as hypothalamus. Histidine 27-30 ghrelin and obestatin prepropeptide Homo sapiens 60-64 1552831-1 1992 The synthetic hexapeptide, His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 (GHRP, Growth Hormone-Releasing Peptide), has no structural similarities with any of the GH-releasing peptides known and its action in releasing GH is by a complementary but yet not clearly defined action on the pituitary as well as hypothalamus. Histidine 27-30 ghrelin and obestatin prepropeptide Homo sapiens 66-98 1778982-0 1991 Substrate-selective activation of histidine-modified porcine pancreatic alpha-amylase by chloride ion. Histidine 34-43 amylase alpha 2A Homo sapiens 61-85 1778982-2 1991 By the modification of histidine residues of porcine pancreatic alpha-amylase with diethylpyrocarbonate (DEP), both amylase and maltosidase activities were decreased in the absence of chloride ion. Histidine 23-32 amylase alpha 2A Homo sapiens 53-77 1665895-3 1991 Furthermore actinomycin D was able to displace [125I]-His-NKA from NK2 receptor sites of the rat small intestine smooth muscle membranes. Histidine 54-57 Natural killer alloreactivity QTL 1 Rattus norvegicus 58-61 1655536-1 1991 Horse heart cytochrome c with either histidine or cysteine replacing the endogenous axial methionine ligand at position 80 has been characterized with magnetic circular dichroism (MCD) spectroscopy in the UV-visible region. Histidine 37-46 cytochrome c, somatic Equus caballus 12-24 2037591-11 1991 The cadherin cell adhesion recognition sequence (His-Ala-Val) is replaced by Phe-Ala-Thr, suggesting that DGII/III may be adhesive molecules using a different mechanism. Histidine 49-52 desmocollin 2 Homo sapiens 106-114 1837452-1 1991 Histidine-containing peptides SHLRKV and DHTLIR, corresponding to placental anticoagulant protein-I (PAP-I) residues 204-209 and 266-271, respectively, are included in the functional site of PAP-I and exhibit anticoagulant activity, but the peptides in which alanine is substituted for histidine do not. Histidine 0-9 annexin A5 Homo sapiens 66-99 1837452-1 1991 Histidine-containing peptides SHLRKV and DHTLIR, corresponding to placental anticoagulant protein-I (PAP-I) residues 204-209 and 266-271, respectively, are included in the functional site of PAP-I and exhibit anticoagulant activity, but the peptides in which alanine is substituted for histidine do not. Histidine 0-9 annexin A5 Homo sapiens 101-106 1837452-1 1991 Histidine-containing peptides SHLRKV and DHTLIR, corresponding to placental anticoagulant protein-I (PAP-I) residues 204-209 and 266-271, respectively, are included in the functional site of PAP-I and exhibit anticoagulant activity, but the peptides in which alanine is substituted for histidine do not. Histidine 0-9 annexin A5 Homo sapiens 191-196 1837452-1 1991 Histidine-containing peptides SHLRKV and DHTLIR, corresponding to placental anticoagulant protein-I (PAP-I) residues 204-209 and 266-271, respectively, are included in the functional site of PAP-I and exhibit anticoagulant activity, but the peptides in which alanine is substituted for histidine do not. Histidine 286-295 annexin A5 Homo sapiens 66-99 1837452-1 1991 Histidine-containing peptides SHLRKV and DHTLIR, corresponding to placental anticoagulant protein-I (PAP-I) residues 204-209 and 266-271, respectively, are included in the functional site of PAP-I and exhibit anticoagulant activity, but the peptides in which alanine is substituted for histidine do not. Histidine 286-295 annexin A5 Homo sapiens 101-106 1837452-1 1991 Histidine-containing peptides SHLRKV and DHTLIR, corresponding to placental anticoagulant protein-I (PAP-I) residues 204-209 and 266-271, respectively, are included in the functional site of PAP-I and exhibit anticoagulant activity, but the peptides in which alanine is substituted for histidine do not. Histidine 286-295 annexin A5 Homo sapiens 191-196 1837452-3 1991 These findings thus suggest that His-205 and His-267 are involved in the Ca(2+)- or the phospholipid-binding site of PAP-I but that His-98 is not. Histidine 33-36 annexin A5 Homo sapiens 117-122 1837452-3 1991 These findings thus suggest that His-205 and His-267 are involved in the Ca(2+)- or the phospholipid-binding site of PAP-I but that His-98 is not. Histidine 45-48 annexin A5 Homo sapiens 117-122 1837452-3 1991 These findings thus suggest that His-205 and His-267 are involved in the Ca(2+)- or the phospholipid-binding site of PAP-I but that His-98 is not. Histidine 45-48 annexin A5 Homo sapiens 117-122 2012805-1 1991 Mouse nerve growth factor (NGF) is cleaved at a histidine-methionine bond to release an NH2-terminal octapeptide (NGF1-8). Histidine 48-57 neurotrophin 3 Mus musculus 114-120 1847138-2 1991 The chemical modification of histidine and arginine residues results in a loss of binding of the Mr 46,000 mannose 6-phosphate receptor (MPR 46) to a phosphomannan affinity matrix (Stein, M., Meyer, J. E., Hasilik, A., and von Figura, K. (1987) Biol. Histidine 29-38 mannose-6-phosphate receptor, cation dependent Homo sapiens 137-143 1847138-6 1991 The 5 histidine and 8 arginine residues within the luminal domain of MPR 46, which contains the ligand binding site, were exchanged by site-directed mutagenesis. Histidine 6-15 mannose-6-phosphate receptor, cation dependent Homo sapiens 69-75 1847138-10 1991 We conclude from these results that His-131 and Arg-137 are essential for binding of ligands by MPR 46. Histidine 36-39 mannose-6-phosphate receptor, cation dependent Homo sapiens 96-102 2069873-8 1991 vav proteins also possess a cysteine-rich domain whose sequence predicts the formation of two putative metal binding-like domains, Cys-X2-Cys-X13-Cys-X2-Cys and His-X2-Cys-X6-Cys-X2-His. Histidine 161-164 vav 1 oncogene Mus musculus 0-3 2069873-8 1991 vav proteins also possess a cysteine-rich domain whose sequence predicts the formation of two putative metal binding-like domains, Cys-X2-Cys-X13-Cys-X2-Cys and His-X2-Cys-X6-Cys-X2-His. Histidine 182-185 vav 1 oncogene Mus musculus 0-3 22358956-3 1991 Preliminary sequence analysis of the zinc finger motifs in these cDNAs indicate that they belong to a subclass of the Cys-Cys/His-His motif, showing the highest homology to the Wilm"s tumor and EGR1, EGR2 cDNAs. Histidine 126-129 early growth response 1 Homo sapiens 194-198 22358956-3 1991 Preliminary sequence analysis of the zinc finger motifs in these cDNAs indicate that they belong to a subclass of the Cys-Cys/His-His motif, showing the highest homology to the Wilm"s tumor and EGR1, EGR2 cDNAs. Histidine 126-129 early growth response 2 Homo sapiens 200-204 22358956-3 1991 Preliminary sequence analysis of the zinc finger motifs in these cDNAs indicate that they belong to a subclass of the Cys-Cys/His-His motif, showing the highest homology to the Wilm"s tumor and EGR1, EGR2 cDNAs. Histidine 130-133 early growth response 1 Homo sapiens 194-198 22358956-3 1991 Preliminary sequence analysis of the zinc finger motifs in these cDNAs indicate that they belong to a subclass of the Cys-Cys/His-His motif, showing the highest homology to the Wilm"s tumor and EGR1, EGR2 cDNAs. Histidine 130-133 early growth response 2 Homo sapiens 200-204 1713327-0 1991 Characterization of His-X3-His sites in alpha-helices of synthetic metal-binding bovine somatotropin. Histidine 20-23 somatotropin Bos taurus 88-100 1713327-0 1991 Characterization of His-X3-His sites in alpha-helices of synthetic metal-binding bovine somatotropin. Histidine 27-30 somatotropin Bos taurus 88-100 1713327-1 1991 Variants of bovine somatotropin have been engineered to contain synthetic metal-binding sites consisting of two solvent-exposed histidines separated by a single turn of an alpha-helix (His-X3-His variants). Histidine 128-138 somatotropin Bos taurus 19-31 1367123-3 1991 Preliminary sequence analysis of the zinc finger motifs in these cDNAs indicate that they belong to a subclass of the Cys-Cys/His-His motif, showing the highest homology to the Wilm"s tumor and EGR1, EGR2 cDNAs. Histidine 126-129 early growth response 1 Homo sapiens 194-198 1367123-3 1991 Preliminary sequence analysis of the zinc finger motifs in these cDNAs indicate that they belong to a subclass of the Cys-Cys/His-His motif, showing the highest homology to the Wilm"s tumor and EGR1, EGR2 cDNAs. Histidine 126-129 early growth response 2 Homo sapiens 200-204 1367123-3 1991 Preliminary sequence analysis of the zinc finger motifs in these cDNAs indicate that they belong to a subclass of the Cys-Cys/His-His motif, showing the highest homology to the Wilm"s tumor and EGR1, EGR2 cDNAs. Histidine 130-133 early growth response 1 Homo sapiens 194-198 1367123-3 1991 Preliminary sequence analysis of the zinc finger motifs in these cDNAs indicate that they belong to a subclass of the Cys-Cys/His-His motif, showing the highest homology to the Wilm"s tumor and EGR1, EGR2 cDNAs. Histidine 130-133 early growth response 2 Homo sapiens 200-204 2079039-2 1990 A crude product of GHRP, a hexapeptide with the sequence His-D-Trp-Ala-Trp-D-Phe-Lys-NH2, synthesized by the solid phase methodology, was desalted and analyzed by CZE. Histidine 57-60 ghrelin and obestatin prepropeptide Homo sapiens 19-23 2170418-6 1990 These regions are located between amino acids Asn-230 and Ile-285 on the IR and between His-223 and Met-274 on the IGFIR. Histidine 88-91 insulin-like growth factor 1 receptor Cricetulus griseus 115-120 2172006-3 1990 Both a conservative change to phenylalanine and a semi-conservative change to histidine at position 37 yield proteins with receptor affinity similar to wild-type hEGF. Histidine 78-87 epidermal growth factor Homo sapiens 162-166 2395880-0 1990 Substitution of a single amino acid (aspartic acid for histidine) converts the functional activity of human complement C4B to C4A. Histidine 55-64 complement C4A (Rodgers blood group) Homo sapiens 126-129 2167456-9 1990 They are bis-histidine, as in mammalian cytochrome b5, methionine-histidine, typified by cytochrome c and lysine-histidine, recently recognized by spectroscopic methods in cytochrome f. Here we report the electron paramagnetic resonance and near infrared magnetic circular dichroism spectra of the oxidized state of Ps. Histidine 13-22 cytochrome b5 type A Homo sapiens 40-53 2167456-9 1990 They are bis-histidine, as in mammalian cytochrome b5, methionine-histidine, typified by cytochrome c and lysine-histidine, recently recognized by spectroscopic methods in cytochrome f. Here we report the electron paramagnetic resonance and near infrared magnetic circular dichroism spectra of the oxidized state of Ps. Histidine 66-75 cytochrome b5 type A Homo sapiens 40-53 2201868-6 1990 ArcB conserved a histidine residue for autophosphorylation of the sensor proteins, and aspartic residues important for the regulator proteins. Histidine 17-26 hypothetical protein Escherichia coli 0-4 2334429-3 1990 This mutation results in an amino-acid replacement of a conserved arginine by histidine at the residue "173," which is involved in an anion-binding site at the P-axis of LDH subunits. Histidine 78-87 lactate dehydrogenase B Homo sapiens 170-173 2179417-8 1990 The mutation at codon 61 of the H-ras gene is consistent with a replacement of glutamine by histidine. Histidine 92-101 HRas proto-oncogene, GTPase Homo sapiens 32-37 2183181-4 1990 By use of a series of deletion mutants of Ski synthesized in an in vitro translation system, two portions in Ski were found to be necessary for the DNA binding of the Ski complex: the N-proximal portion containing a cystein/histidine-rich domain and the C-terminal portion including a region rich in basic amino acids. Histidine 224-233 SKI proto-oncogene Homo sapiens 109-112 33821889-8 2021 Based on spectroscopic, kinetic, and electrochemical studies, we deduce that DOPA residue, when present within the distal pocket of mutant Mb, alone serves the role of His/Arg-pair of peroxidases. Histidine 168-171 myoglobin Homo sapiens 139-141 33588277-8 2021 The copper(II) binding affinity of the native fragment of tau protein is comparable to that of a similar 2-histidine fragment of amyloid-beta mutant, Ac-SGAEGHHQK-NH2 but the comparison with an independent histidyl residue (H32) from the N-terminal region of the protein reveals the predominance of H32 over the histidines in the R3 domain. Histidine 312-322 microtubule associated protein tau Homo sapiens 58-61 11939778-0 2002 Structural dynamics of distal histidine replaced mutants of myoglobin accompanied with the photodissociation reaction of the ligand. Histidine 30-39 myoglobin Homo sapiens 60-69 11939778-1 2002 Protein dynamics observed by the transient grating (TG) method are studied for some site-directed mutants at the distal histidine of myoglobin (H64L, H64Q, H64V). Histidine 120-129 myoglobin Homo sapiens 133-142 34962759-3 2022 Upon measuring the tautomer ratios of several histidine residues in myoglobin, we find good agreement with previous 2D NMR data on this protein. Histidine 46-55 myoglobin Homo sapiens 68-77 34383999-1 2021 HLA-B*46:64 has one nucleotide change from HLA-B*46:01:01:01 where Histidine (113) is changed to Arginine. Histidine 67-76 major histocompatibility complex, class I, B Homo sapiens 43-48 34425475-1 2021 Reactions of the anticancer active dirhodium tetraacetate (1), Rh2(AcO)4 (AcO- = CH3COO-), with the amino acid histidine (HHis) and human serum albumin (HSA) were monitored over time and different metal: ligand ratios using UV-vis spectroscopy and/or electro-spray ionization mass spectrometry. Histidine 111-120 Rh associated glycoprotein Homo sapiens 63-72 34606713-4 2021 We use histidine-heme loop formation methods, employing eight single histidine variants, to probe for denatured state conformational bias of a UBA(1) domain fused to the N-terminus of iso-1-cytochrome c (iso-1-Cytc). Histidine 7-16 ubiquitin like modifier activating enzyme 1 Homo sapiens 143-149 34231327-5 2021 Considering Tau and Pi tautomeric forms of histidine (Tau and Pi tautomers are denoted as epsilon and delta, respectively), simulations were performed on two possible isomers of amylin. Histidine 43-52 microtubule associated protein tau Homo sapiens 12-15 34125142-0 2021 Histidine ameliorates elastase- and lipopolysaccharide-induced lung inflammation by inhibiting the activation of the NLRP3 inflammasome. Histidine 0-9 NLR family, pyrin domain containing 3 Mus musculus 117-122 34125142-7 2021 In addition, histidine treatment ameliorated lung inflammation by inhibiting the nucleotide-binding oligomerization domain-like receptor (NLR) family pyrin domain-containing 3 inflammasome activation both in vivo and in vitro. Histidine 13-22 NLR family, pyrin domain containing 3 Mus musculus 81-175 34361714-6 2021 In addition, hydrogen bonding occurred between hypericin and alpha-glucosidase amino acid residues Lys-156, Ser-157, Gly-160, Ser-240, His-280, Asp-242, and Asp-307. Histidine 135-138 sucrase-isomaltase Homo sapiens 61-78 34233759-6 2021 RESULTS: Thirteen metabolites were identified as common biomarkers discriminating ob/ob mice and lepb-/- zebrafish larvae from their respective wild type controls: alanine, citrulline, ethanolamine, glutamine, glycine, histidine, isoleucine, leucine, methionine, phenylalanine, putrescine, serine and threonine. Histidine 219-228 leptin Mus musculus 82-84 35429859-3 2022 A water-soluble histidine-modified perylene diimide fluorescent probe was synthesized by a one-step method, and the probe can form supramolecular aggregates in the presence of Cd2+. Histidine 16-25 CD2 molecule Homo sapiens 176-179 35587229-1 2022 A convergent synthesis provided nearly perfect tau-ADP-ribosylated histidine isosteres (His*-tau-ADPr) via a copper(I)-catalyzed cycloaddition between an azido-ADP-ribosyl analogue and an oligopeptide carrying a propargyl glycine. Histidine 88-91 microtubule associated protein tau Homo sapiens 47-50 35587229-1 2022 A convergent synthesis provided nearly perfect tau-ADP-ribosylated histidine isosteres (His*-tau-ADPr) via a copper(I)-catalyzed cycloaddition between an azido-ADP-ribosyl analogue and an oligopeptide carrying a propargyl glycine. Histidine 88-91 microtubule associated protein tau Homo sapiens 93-96 35460908-4 2022 In brief, Met and glucose oxidase (GOx) was encapsulated into histidine/zeolitic imidazolate framework-8 (His/ZIF-8), which was followed by coating with Arg-Gly-Asp (RGD) peptides to obtain the desired nanomedicine (Met/GOx@His/ZIF-8~RGD). Histidine 62-71 SAFB like transcription modulator Homo sapiens 10-13 35460908-4 2022 In brief, Met and glucose oxidase (GOx) was encapsulated into histidine/zeolitic imidazolate framework-8 (His/ZIF-8), which was followed by coating with Arg-Gly-Asp (RGD) peptides to obtain the desired nanomedicine (Met/GOx@His/ZIF-8~RGD). Histidine 62-71 SAFB like transcription modulator Homo sapiens 216-219 35158417-4 2022 After targeting and permeating BBB, the histidine units in the DPH chelate excess metal ions at the extracellular microenvironment, restraining the formation of Abeta aggregates, and induce the first-stage separation. Histidine 40-49 amyloid beta (A4) precursor protein Mus musculus 161-166 35194938-1 2022 Prune exopolyphosphatase-1 (PRUNE1) encodes a member of the aspartic acid-histidine-histidine (DHH) phosphodiesterase superfamily that regulates cell migration and proliferation during brain development. Histidine 74-83 prune exopolyphosphatase 1 Homo sapiens 0-26 35194938-1 2022 Prune exopolyphosphatase-1 (PRUNE1) encodes a member of the aspartic acid-histidine-histidine (DHH) phosphodiesterase superfamily that regulates cell migration and proliferation during brain development. Histidine 74-83 prune exopolyphosphatase 1 Homo sapiens 28-34 35194938-1 2022 Prune exopolyphosphatase-1 (PRUNE1) encodes a member of the aspartic acid-histidine-histidine (DHH) phosphodiesterase superfamily that regulates cell migration and proliferation during brain development. Histidine 84-93 prune exopolyphosphatase 1 Homo sapiens 0-26 35194938-1 2022 Prune exopolyphosphatase-1 (PRUNE1) encodes a member of the aspartic acid-histidine-histidine (DHH) phosphodiesterase superfamily that regulates cell migration and proliferation during brain development. Histidine 84-93 prune exopolyphosphatase 1 Homo sapiens 28-34 35609862-4 2022 The C-terminal cytosolic domain of mitoNEET binds a (2Fe-2S) cluster via three cysteine and one histidine residues. Histidine 96-105 CDGSH iron sulfur domain 1 Homo sapiens 35-43 35557955-1 2022 Human NEET proteins, such as NAF-1 and mitoNEET, are homodimeric, redox iron-sulfur proteins characterized by triple cysteine and one histidine-coordinated (2Fe-2S) cluster. Histidine 134-143 nuclear assembly factor 1 ribonucleoprotein Homo sapiens 29-34 35557955-1 2022 Human NEET proteins, such as NAF-1 and mitoNEET, are homodimeric, redox iron-sulfur proteins characterized by triple cysteine and one histidine-coordinated (2Fe-2S) cluster. Histidine 134-143 CDGSH iron sulfur domain 1 Homo sapiens 39-47 35216507-5 2022 The inhibitors successfully engaged the catalytic dyad histidine residue (H41) of 3CLPro as designed, and they exhibited nanomolar inhibitory capacity as well as mitigated the viral loads of SARS-CoV-2 in cellular assays. Histidine 55-64 CDV3 homolog Homo sapiens 74-77 35129437-5 2022 A glutamine-rich low complexity domain (QLC) in the SNF5 subunit of this complex, and histidines within this sequence, were required for efficient transcriptional reprogramming. Histidine 86-96 Snf5p Saccharomyces cerevisiae S288C 52-56 35129437-7 2022 Simulations showed that protonation of histidines within the SNF5 QLC lead to conformational expansion, providing a potential biophysical mechanism for regulation of these interactions. Histidine 39-49 Snf5p Saccharomyces cerevisiae S288C 61-65 35225667-9 2022 In this study, we tried to determine the binding epitope of rituximab for CD20 using histidine-tag insertion for epitope mapping (HisMAP) method. Histidine 85-94 membrane-spanning 4-domains, subfamily A, member 1 Mus musculus 74-78 2691018-5 1989 A point mutation at this location corresponds to a substitution of histidine for glutamine in the N-ras gene product, p21. Histidine 67-76 H3 histone pseudogene 16 Homo sapiens 118-121 2692849-2 1989 The ADE3 locus encodes the trifunctional enzyme C1-tetrahydrofolate synthase, which is required for the biosynthesis of purines, thymidylate, methionine, histidine, pantothenic acid and formylmethionyl-tRNA(fMet. Histidine 154-163 trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase ADE3 Saccharomyces cerevisiae S288C 4-8 2526198-8 1989 The results demonstrate that CpAse H catalyses the release of C-terminal histidine with great difficulty. Histidine 73-82 carboxypeptidase E Homo sapiens 29-36 2567165-4 1989 The tyrosinase gene in the Himalayan mouse contains an A----G change at nucleotide 1259 that alters a histidine residue to an arginine residue at amino acid 420. Histidine 102-111 tyrosinase Mus musculus 4-14 2566116-4 1989 This mutation converts the 340th amino acid of NADH dehydrogenase subunit 4 from an arginine to a histidine and eliminates an SfaNI endonuclease restriction site. Histidine 98-107 mitochondrially encoded NADH dehydrogenase 4 Homo sapiens 47-75 2765496-9 1989 The LPL hydrolysis reaction is base catalyzed, exhibiting two pKa values; the more acidic of these is 6.5, consistent with base catalysis by histidine. Histidine 141-150 lipoprotein lipase Homo sapiens 4-7 2707256-0 1989 The histidine residue of codon 715 is essential for function of elongation factor 2. Histidine 4-13 eukaryotic translation elongation factor 2 Mus musculus 64-83 2707256-2 1989 Amino acid substitution for the histidine residue of codon 715, which is modified post-translationally to diphthamide, resulted in non-functional EF-2 and this substitution did not render EF-2 resistant to Pseudomonas aeruginosa exotoxin A, which inactivates EF-2 transferring ADP-ribose to the diphthamide residue. Histidine 32-41 eukaryotic translation elongation factor 2 Mus musculus 146-150 2764952-1 1989 Changes in the circular dichroic and absorption spectra were studied on solutions of myoglobin whose histidine residues had been modified by carboxymethylation under denaturing conditions. Histidine 101-110 myoglobin Homo sapiens 85-94 2764952-3 1989 This was accompanied by a remarkable change in the secondary structure of the protein involving helix-to-random coil transition, indicating that extensive histidine modification prevented unfolded myoglobin from refolding to its native conformation. Histidine 155-164 myoglobin Homo sapiens 197-206 2839508-2 1988 While each isozyme is encoded by the same structural gene, they differ by the amino acid sequence at the COOH-terminal end, with GPDH-3 having the sequence Asn-His-Pro-Glu-His-Met-COOH and with GPDH-1 extended by the three amino acid sequence Glu-Asn-Leu-COOH. Histidine 160-163 uncharacterized protein Drosophila melanogaster 129-135 2839508-2 1988 While each isozyme is encoded by the same structural gene, they differ by the amino acid sequence at the COOH-terminal end, with GPDH-3 having the sequence Asn-His-Pro-Glu-His-Met-COOH and with GPDH-1 extended by the three amino acid sequence Glu-Asn-Leu-COOH. Histidine 172-175 uncharacterized protein Drosophila melanogaster 129-135 3131338-4 1988 Diethyl pyrocarbonate measurements indicate that the old enzyme has 1 histidine residue less than the young enzyme. Histidine 70-79 hyaluronan synthase 1 Rattus norvegicus 64-69 2835106-4 1988 The studies reported in this paper were undertaken to determine whether histidine modification was involved in the decrease in effectiveness of cytochrome b5, or whether the inactivation could be attributed to modification of another amino acid. Histidine 72-81 cytochrome b5 type A Homo sapiens 144-157 2835106-5 1988 Our experiments demonstrate that diethylpyrocarbonate inactivates detergent-solubilized cytochrome b5 by modifying the axial histidines and displacing the heme. Histidine 125-135 cytochrome b5 type A Homo sapiens 88-101 3427072-2 1987 The first histidine in this sequence in the tyrosyl-tRNA synthetase, His-45, has been shown to form part of a binding site for the gamma-phosphate of ATP in the transition state for the reaction as does Thr-40. Histidine 10-19 tyrosyl-tRNA synthetase 1 Homo sapiens 44-67 3427072-2 1987 The first histidine in this sequence in the tyrosyl-tRNA synthetase, His-45, has been shown to form part of a binding site for the gamma-phosphate of ATP in the transition state for the reaction as does Thr-40. Histidine 69-72 tyrosyl-tRNA synthetase 1 Homo sapiens 44-67 3663595-5 1987 258, 14048-14053] at low denaturant concentration was detected here by discontinuous changes in the chemical shifts of the C(2) protons of two of the five histidines in human antithrombin III and of three of the six histidines in bovine antithrombin III. Histidine 155-165 serpin family C member 1 Homo sapiens 175-191 3663595-5 1987 258, 14048-14053] at low denaturant concentration was detected here by discontinuous changes in the chemical shifts of the C(2) protons of two of the five histidines in human antithrombin III and of three of the six histidines in bovine antithrombin III. Histidine 155-165 serpin family C member 1 Homo sapiens 237-253 3663595-5 1987 258, 14048-14053] at low denaturant concentration was detected here by discontinuous changes in the chemical shifts of the C(2) protons of two of the five histidines in human antithrombin III and of three of the six histidines in bovine antithrombin III. Histidine 216-226 serpin family C member 1 Homo sapiens 175-191 3663595-5 1987 258, 14048-14053] at low denaturant concentration was detected here by discontinuous changes in the chemical shifts of the C(2) protons of two of the five histidines in human antithrombin III and of three of the six histidines in bovine antithrombin III. Histidine 216-226 serpin family C member 1 Homo sapiens 237-253 3663595-6 1987 These two histidines in human antithrombin III are assigned to residue 1 and, more tentatively, to residue 65. Histidine 10-20 serpin family C member 1 Homo sapiens 30-46 3663595-10 1987 From the tentative assignment of one of these resonances to histidine-1, it is proposed that the heparin binding site of antithrombin III is located in the N-terminal region and that this region forms a separate domain from the rest of the protein. Histidine 60-69 serpin family C member 1 Homo sapiens 121-137 3663595-12 1987 Thermal denaturation also leads to major perturbation of these two histidine resonances in human antithrombin III, though stable intermediates in the unfolding were not detected. Histidine 67-76 serpin family C member 1 Homo sapiens 97-113 3036144-3 1987 The NO-ferrous cytochrome c" would be a mixture of NO complexes with six- and five-coordinate nitrosylheme, suggesting that the heme-iron to histidine bond in the ferrous cytochrome c" is more stable than that from chemoheterotrophic bacteria. Histidine 141-150 cytochrome c, somatic Equus caballus 15-27 3036144-3 1987 The NO-ferrous cytochrome c" would be a mixture of NO complexes with six- and five-coordinate nitrosylheme, suggesting that the heme-iron to histidine bond in the ferrous cytochrome c" is more stable than that from chemoheterotrophic bacteria. Histidine 141-150 cytochrome c, somatic Equus caballus 171-183 2821278-1 1987 A re-examination of the C-2 histidine proton resonances of haemoglobins A and Cowtown (His HC3(146) beta----Leu) in chloride-free Hepes buffer has shown that all the resonances present in haemoglobin A are present in haemoglobin Cowtown, so that the pKa of His HC3(146) beta cannot be determined by nuclear magnetic resonance in this buffer. Histidine 28-37 complement C2 Homo sapiens 24-27 3030432-5 1987 The function of the heme c moieties in the catalytic cycle of the enzyme is discussed on the basis of their homology with the proximal histidine region of peroxidase (horseradish peroxidase and yeast cytochrome-c peroxidase) and cytochromes (horse cytochrome c and Pseudomonas cytochrome c-551). Histidine 135-144 cytochrome c, somatic Equus caballus 248-260 3030432-5 1987 The function of the heme c moieties in the catalytic cycle of the enzyme is discussed on the basis of their homology with the proximal histidine region of peroxidase (horseradish peroxidase and yeast cytochrome-c peroxidase) and cytochromes (horse cytochrome c and Pseudomonas cytochrome c-551). Histidine 135-144 cytochrome c, somatic Equus caballus 277-289 3548429-1 1987 Less than Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2, the luteinizing hormone-releasing hormone, LHRH, is degraded in renal proximal tubules (PT) in vivo (rat) and in vitro (rabbit) to less than Glu-His (2), less than Glu-His-Trp (3), and less than Glu-His-Trp-Ser (4). Histidine 14-17 gonadotropin releasing hormone 1 Rattus norvegicus 98-102 3548429-1 1987 Less than Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2, the luteinizing hormone-releasing hormone, LHRH, is degraded in renal proximal tubules (PT) in vivo (rat) and in vitro (rabbit) to less than Glu-His (2), less than Glu-His-Trp (3), and less than Glu-His-Trp-Ser (4). Histidine 200-203 gonadotropin releasing hormone 1 Rattus norvegicus 59-96 3548429-1 1987 Less than Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2, the luteinizing hormone-releasing hormone, LHRH, is degraded in renal proximal tubules (PT) in vivo (rat) and in vitro (rabbit) to less than Glu-His (2), less than Glu-His-Trp (3), and less than Glu-His-Trp-Ser (4). Histidine 200-203 gonadotropin releasing hormone 1 Rattus norvegicus 98-102 3548429-1 1987 Less than Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2, the luteinizing hormone-releasing hormone, LHRH, is degraded in renal proximal tubules (PT) in vivo (rat) and in vitro (rabbit) to less than Glu-His (2), less than Glu-His-Trp (3), and less than Glu-His-Trp-Ser (4). Histidine 200-203 gonadotropin releasing hormone 1 Rattus norvegicus 59-96 3548429-1 1987 Less than Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2, the luteinizing hormone-releasing hormone, LHRH, is degraded in renal proximal tubules (PT) in vivo (rat) and in vitro (rabbit) to less than Glu-His (2), less than Glu-His-Trp (3), and less than Glu-His-Trp-Ser (4). Histidine 200-203 gonadotropin releasing hormone 1 Rattus norvegicus 98-102 3548429-1 1987 Less than Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2, the luteinizing hormone-releasing hormone, LHRH, is degraded in renal proximal tubules (PT) in vivo (rat) and in vitro (rabbit) to less than Glu-His (2), less than Glu-His-Trp (3), and less than Glu-His-Trp-Ser (4). Histidine 200-203 gonadotropin releasing hormone 1 Rattus norvegicus 59-96 3548429-1 1987 Less than Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2, the luteinizing hormone-releasing hormone, LHRH, is degraded in renal proximal tubules (PT) in vivo (rat) and in vitro (rabbit) to less than Glu-His (2), less than Glu-His-Trp (3), and less than Glu-His-Trp-Ser (4). Histidine 200-203 gonadotropin releasing hormone 1 Rattus norvegicus 98-102 3548429-4 1987 [D-Ser4]LHRH was not cleaved at D Ser4-Tyr5 but yielded less than Glu-His-Trp-D-Ser-Tyr-Gly as the major metabolite plus 2 and 3. Histidine 70-73 gonadotropin releasing hormone 1 Rattus norvegicus 8-12 3548429-8 1987 [3H]LHRH was cleaved by BBM or by endopeptidase-24.11 from porcine PT to metabolites 2, 4, small amounts of 3, and less than Glu-His-Trp-Ser-Tyr-Gly, but cleavage was strongly inhibited by the specific inhibitor phosphoramidon. Histidine 129-132 gonadotropin releasing hormone 1 Rattus norvegicus 4-8 3026342-14 1986 Reaction of diethyl pyrocarbonate-treated alpha 2M with hydroxylamine reversed derivatization of 43 of the 53 histidine residues. Histidine 110-119 alpha-2-macroglobulin Homo sapiens 42-50 3720741-1 1986 Active-site histidine residues of bovine seminal RNase have been found to react with bromoacetic acid and with 2"(3")-O-bromoacetyluridine (BrAcUrd) at a much faster rate than free histidine. Histidine 12-21 seminal ribonuclease Bos taurus 41-54 3720741-1 1986 Active-site histidine residues of bovine seminal RNase have been found to react with bromoacetic acid and with 2"(3")-O-bromoacetyluridine (BrAcUrd) at a much faster rate than free histidine. Histidine 181-190 seminal ribonuclease Bos taurus 41-54 3736769-5 1986 His was reduced by about 90% in the CSF, in the plasma and in the urine. Histidine 0-3 colony stimulating factor 2 Homo sapiens 36-39 3537709-6 1986 The effect of gcd5 is a posttranscriptional increase in histidine biosynthetic enzyme activity. Histidine 56-65 lysine--tRNA ligase KRS1 Saccharomyces cerevisiae S288C 14-18 3905974-6 1985 Both [32P] phosphate and [3H]histidine were incorporated into the high-Mr band after pulse labeling for 3 h. After a 15-h chase, [3H]histidine, but not [32P]phosphate appeared in filaggrin. Histidine 133-142 filaggrin Homo sapiens 179-188 3905974-11 1985 These studies suggest that human skin filaggrin, like rodent filaggrin, is synthesized as a high-Mr, phosphorylated, histidine-rich precursor (profilaggrin) that is processed via posttranslational modification to filaggrin. Histidine 117-126 filaggrin Homo sapiens 38-47 2864083-6 1985 In contrast, the observed inactivation of the enzyme by p-hydroxymercuribenzoate or p-hydroxymercuriphenylsulfonate is probably due to a modification of a histidine residue, consistent with previous reports that histidine is near the active site of arylsulfatase A. Histidine 155-164 arylsulfatase A Oryctolagus cuniculus 249-264 2864083-6 1985 In contrast, the observed inactivation of the enzyme by p-hydroxymercuribenzoate or p-hydroxymercuriphenylsulfonate is probably due to a modification of a histidine residue, consistent with previous reports that histidine is near the active site of arylsulfatase A. Histidine 212-221 arylsulfatase A Oryctolagus cuniculus 249-264 2860921-2 1985 The Cd2+ binding loci consist of the two His(B10) sites and a new site involving the Glu(B13) residues located at the center of the hexamer [Sudmeier, J. L., Bell, S. J., Storm, M. C., & Dunn, M. F. (1981) Science (Washington, D.C.) 212, 560-562]. Histidine 41-44 CD2 molecule Homo sapiens 4-7 3871336-3 1985 The pH dependence of the chemical shift of the C-2 carbon in the histidine ring of carnosine was used for estimation of the intracellular pH in the intact muscle. Histidine 65-74 complement C2 Homo sapiens 47-50 3905514-9 1985 The hip1 deletion mutant can grow when it is supplemented with 30 mM histidine, 50 times the amount required for the growth of HIP1 cells. Histidine 69-78 histidine permease Saccharomyces cerevisiae S288C 4-8 3905514-9 1985 The hip1 deletion mutant can grow when it is supplemented with 30 mM histidine, 50 times the amount required for the growth of HIP1 cells. Histidine 69-78 histidine permease Saccharomyces cerevisiae S288C 127-131 3904081-4 1985 The sites of cleavage in the oxidized B chain of insulin were identified as Ser(9)-His(10), His(10)-Leu(11), Ala(14)-Leu(15), Leu(15)-Tyr(16) and Tyr(16)-Leu(17). Histidine 83-86 insulin Protobothrops mucrosquamatus 49-56 3904081-4 1985 The sites of cleavage in the oxidized B chain of insulin were identified as Ser(9)-His(10), His(10)-Leu(11), Ala(14)-Leu(15), Leu(15)-Tyr(16) and Tyr(16)-Leu(17). Histidine 92-95 insulin Protobothrops mucrosquamatus 49-56 6096143-2 1984 The results show that the replacement of the distal histidine of the hemoglobin beta chains by an arginine greatly enhances the susceptibility of the heme-iron to oxidative challenge. Histidine 52-61 hemoglobin subunit beta Homo sapiens 69-84 6203787-1 1984 The identification of PHI (the 27-amino acid peptide (P) having an N-terminal histidine (H) and a C-terminal isoleucine amide (I] in median eminence suggested that PHI influences the secretory function of the anterior pituitary. Histidine 78-87 glucose-6-phosphate isomerase Rattus norvegicus 22-25 6203787-1 1984 The identification of PHI (the 27-amino acid peptide (P) having an N-terminal histidine (H) and a C-terminal isoleucine amide (I] in median eminence suggested that PHI influences the secretory function of the anterior pituitary. Histidine 78-87 glucose-6-phosphate isomerase Rattus norvegicus 164-167 6712945-3 1984 These high-molecular-weight filaggrin precursors can be rapidly labeled with histidine and extracted from the epidermis under denaturing conditions. Histidine 77-86 filaggrin Homo sapiens 28-37 6319392-14 1984 The 6-phosphofructo-2-kinase, fructose 2,6-bisphosphatase, and ATP/ADP exchange were all inhibited by diethylpyrocarbonate, suggesting the involvement of histidine residues in all three reactions. Histidine 154-163 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 Homo sapiens 4-57 6360218-0 1983 Direct tritium-labelling into histidine of luteinizing hormone-releasing hormone agonists and use of the tracers in studies on proteolytic breakdown. Histidine 30-39 gonadotropin releasing hormone 1 Rattus norvegicus 43-80 6360218-2 1983 In the present study, conditions for the direct 3H-labelling at the histidine residue of analogs of LHRH were worked out, circumventing the synthesis of precursor peptides for labelling. Histidine 68-77 gonadotropin releasing hormone 1 Rattus norvegicus 100-104 6311172-5 1983 Spectroscopic measurements of pKa values for Lys-55 (horse and tuna cytochromes c) and His-33 and His-39 (C. krusei and S. cerevisiae cytochromes c) are in excellent agreement with expectations based on chemical-modification studies of horse cytochrome c. Histidine 87-90 cytochrome c, somatic Equus caballus 242-254 6871162-5 1983 Guaiacol, o-toluidine, and histidine brought about a frequency shift of the v4 mode for LPO but not for HRP. Histidine 27-36 lactoperoxidase Bos taurus 88-91 6135456-3 1983 Data from protein photooxidation in the presence of methylene blue and the type of pH-dependence of pKm suggest that glutamate binding takes place on the imidazole ring of the histidine molecule. Histidine 176-185 pyruvate kinase M1/2 Homo sapiens 100-103 6633518-6 1983 Two of the peptides of the 11K complex appear to be derived from the 19K fragment of the ceruloplasmin molecule (18); one peptide in the complex appears to correspond to the aspartic acid-rich portion, residues 7-30, and the other to the histidine-rich portion, residues 103-157. Histidine 238-247 ceruloplasmin Homo sapiens 89-102 6216475-6 1982 The Thr at position 55 in plasminogen (plasmin) Tochigi may perturb His-57 such that the proton transfers associated with the normal catalytic process cannot occur in the abnormal plasmin. Histidine 68-71 plasminogen Bos taurus 26-33 6216475-6 1982 The Thr at position 55 in plasminogen (plasmin) Tochigi may perturb His-57 such that the proton transfers associated with the normal catalytic process cannot occur in the abnormal plasmin. Histidine 68-71 plasminogen Bos taurus 39-46 6294750-2 1982 The presence of receptors, recognized by vasoactive intestinal peptide (VIP) as well as by PHI (a peptide with N-terminal histidine and C-terminal isoleucine amide), was documented in lung membranes from rat, mouse, guinea pig and man by the ability of these receptors, once occupied, to stimulate adenylate cyclase. Histidine 122-131 glucose-6-phosphate isomerase Rattus norvegicus 91-94 7118436-2 1982 This rate is independent of pH throughout the pH range 5.5-8.5 as determined by pH jump from low pH with potentiometric recording of the slow approach to equilibrium pH, and by integration of the histidine C-2 and C-4 proton n.m.r. Histidine 196-205 complement C2 Rattus norvegicus 206-209 6297137-1 1982 Chemical modification of a histidine and lysine residue inactivates pea seed nucleoside diphosphate kinase (NDP kinase). Histidine 27-36 cytidine/uridine monophosphate kinase 2 Homo sapiens 77-106 6297137-1 1982 Chemical modification of a histidine and lysine residue inactivates pea seed nucleoside diphosphate kinase (NDP kinase). Histidine 27-36 cytidine/uridine monophosphate kinase 2 Homo sapiens 108-118 6297137-2 1982 Thus there seems to be a reactive lysine residue, at the active site of pea seed NDP kinase, in addition to the histidine residue phosphorylated by the substrate ATP as a consequence of the enzyme reaction. Histidine 112-121 cytidine/uridine monophosphate kinase 2 Homo sapiens 81-91 7299136-8 1981 These results suggest that the positively charged residues His-285, Lys-288, Lys-290, and Arg-292, which are located on the outer surface of the C gamma 2 domain, may be involved in the C1q-binding site of human IgG. Histidine 59-62 complement C1q A chain Homo sapiens 186-189 6167582-4 1981 The C4a anaphylatoxin is a cationic polypeptide of Mr = 9000 composed of 77 residues and devoid of histidine, tryptophan, and carbohydrate. Histidine 99-108 complement C4A (Rodgers blood group) Homo sapiens 4-7 7019446-1 1981 Metabolic breakdown of the luteinizing hormone-releasing hormone (LH-RH) could lead to the following fragments containing pyroglutamic acid: pyroglutamic acid (1), pGlu-His (2), pGLu-His-Trp (3), pGlu-His-Trp-Ser (4), etc., and finally pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly (10). Histidine 183-186 gonadotropin releasing hormone 1 Rattus norvegicus 27-64 7019446-1 1981 Metabolic breakdown of the luteinizing hormone-releasing hormone (LH-RH) could lead to the following fragments containing pyroglutamic acid: pyroglutamic acid (1), pGlu-His (2), pGLu-His-Trp (3), pGlu-His-Trp-Ser (4), etc., and finally pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly (10). Histidine 183-186 gonadotropin releasing hormone 1 Rattus norvegicus 66-71 6970745-4 1981 C4a is devoid of tryptophan, histidine, and carbohydrate. Histidine 29-38 complement C4A (Rodgers blood group) Homo sapiens 0-3 6987229-0 1980 Primary structure of a histidine-rich proteolytic fragment of human ceruloplasmin. Histidine 23-32 ceruloplasmin Homo sapiens 68-81 6987229-2 1980 A histidine-rich fragment, Cp F5, with a molecular weight of 18,650 was isolated from human ceruloplasmin. Histidine 2-11 ceruloplasmin Homo sapiens 92-105 6987230-0 1980 Primary structure of a histidine-rich proteolytic fragment of human ceruloplasmin. Histidine 23-32 ceruloplasmin Homo sapiens 68-81 6987230-3 1980 Amino acid sequence studies of tryptic peptides isolated from a histidine-rich fragment (Cp F5) of human ceruloplasmin are described. Histidine 64-73 ceruloplasmin Homo sapiens 105-118 7014359-1 1980 The frequency of UV-induced arg+ and his+ reversions is found to be enhanced by the presence of colicinogenic plasmids Ib-P9 and Ia-CA53 and reduced by the presence of plasmid V-K30. Histidine 37-40 cellular communication network factor 3 Homo sapiens 119-124 115864-2 1979 An enzyme which catalyzes the deamidation of thyroliberin (TRF; less than Glu-His-Pro-NH2) has been purified 110-fold from extracts of bovine anterior pituitary by ammonium sulfate fractionation, ion exchange chromatography on DEAE-cellulose, and gel filtration. Histidine 78-81 interleukin 5 Bos taurus 59-62 655262-4 1978 This acyl hydrolase activity can be simply and efficiently removed on a large scale by treatment of CoF with p-bromophenacyl bromide (BPB), an irreversible modifier of the histidine residue in the active site of phospholipase A2. Histidine 172-181 phospholipase A2 Oryctolagus cuniculus 212-228 83954-0 1978 The effect of L-thyroxine, antithyroid substances and L-histidine on either form of catalase in guinea pig liver and brain. Histidine 54-65 catalase Cavia porcellus 84-92 16883-0 1977 Magnetic resonance studies of concanavalin A: assignment of histidine resonances in 220 MHz proton spectrum of complexes with Co2+ and Zn2+. Histidine 60-69 complement C2 Homo sapiens 126-129 16883-3 1977 The magnitude of these shifts can be used to determine the orientation of axis of anisotropy of the Co2+ ligand field since the distances from the C2 protons of the histidines to S1 can be computed from the crystal structure coordinates. Histidine 165-175 complement C2 Homo sapiens 100-103 892988-3 1977 A description is given of the synthesis by fragment condensation of the peptides Glu-Ser-Ser-Ala-Asp-Lys-Phe-Lys-Arg-Gln-His-Met-Asp and Gly-Glu-Ser-Arg-Glu-Ser-Ser-Ala-Asp-Lys-Phe-Lys-Arg-Gln-His-Met-Asp respectively corresponding to the 5-17 and 1-17 amino acid sequences of rat pancreatic ribonuclease. Histidine 121-124 ribonuclease A family member 1, pancreatic Rattus norvegicus 281-304 12155-0 1976 Hydrogen-deuterium exchange in the histidine residues of bovine alpha-lactalbumin. Histidine 35-44 lactalbumin alpha Bos taurus 64-81 781528-4 1976 The right arm is marked with ade3 (simultaneous requirement for adenine and histidine). Histidine 76-85 trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase ADE3 Saccharomyces cerevisiae S288C 29-33 4590450-0 1973 The role of histidine residues in yeast hexokinase. Histidine 12-21 hexokinase Saccharomyces cerevisiae S288C 40-50 5780195-0 1969 Hemoglobin Hasharon (alpha-2-47 his(CD5)beta-2): a hemoglobin found in low concentration. Histidine 32-35 CD5 molecule Homo sapiens 36-39 5922545-16 1966 They differed, however, in that the Qbeta-protein lacked tryptophan and histidine, whereas the MS-2 protein lacked only histidine. Histidine 120-129 MS2 Homo sapiens 95-99 34032179-8 2021 We propose that His-190 may play a role in the hydrolysis of pyrophosphate from GTP and in releasing the product, DARP. Histidine 16-19 ankyrin repeat domain 23 Homo sapiens 114-118 33360738-0 2021 The interaction of half-sandwich (eta5-Cp*)Rh(III) cation with histidine containing peptides and their ternary species with (N,N) bidentate ligands. Histidine 63-72 ceruloplasmin Homo sapiens 39-42 33360738-1 2021 Our goal was to explore the possible interactions of the potential metallodrug (eta5-Cp*)Rh(III) complexes with histidine containing biomolecules (peptides/proteins) in order to understand the most important thermodynamic factors influencing the biospeciation and biotransformation of (eta5-Cp*)Rh(III) complexes. Histidine 112-121 ceruloplasmin Homo sapiens 85-88 33360738-1 2021 Our goal was to explore the possible interactions of the potential metallodrug (eta5-Cp*)Rh(III) complexes with histidine containing biomolecules (peptides/proteins) in order to understand the most important thermodynamic factors influencing the biospeciation and biotransformation of (eta5-Cp*)Rh(III) complexes. Histidine 112-121 ceruloplasmin Homo sapiens 291-294 33360738-2 2021 To this end, here we report systematic solution thermodynamic and solution structural study on the interaction of (eta5-Cp*)Rh(III) cation with histidine containing peptides and their constituents ((N-methyl)imidazole, GGA-OH, GGH-OH, histidine-amide, HGG-OH, GHG-NH2), based on extensive 1H NMR, ESI-MS and potentiometric investigations. Histidine 144-153 ceruloplasmin Homo sapiens 120-123 33360738-2 2021 To this end, here we report systematic solution thermodynamic and solution structural study on the interaction of (eta5-Cp*)Rh(III) cation with histidine containing peptides and their constituents ((N-methyl)imidazole, GGA-OH, GGH-OH, histidine-amide, HGG-OH, GHG-NH2), based on extensive 1H NMR, ESI-MS and potentiometric investigations. Histidine 144-153 gamma-glutamyl hydrolase Homo sapiens 227-230 33360738-5 2021 At pH 7.4 the (eta5-Cp*)Rh(III) binding affinity of peptides follow the order GGA-OH < < GGH-OH < < histidine-amide < HGG-OH < GHG-NH2, i.e. the observed binding strength essentially depends on the presence and position of histidine within the peptide sequence. Histidine 100-109 ceruloplasmin Homo sapiens 20-23 33360738-5 2021 At pH 7.4 the (eta5-Cp*)Rh(III) binding affinity of peptides follow the order GGA-OH < < GGH-OH < < histidine-amide < HGG-OH < GHG-NH2, i.e. the observed binding strength essentially depends on the presence and position of histidine within the peptide sequence. Histidine 223-232 ceruloplasmin Homo sapiens 20-23 33718276-4 2021 Our recent study has shown that ZIKV capsid protein interacted with Dicer and antagonized its endoribonuclease activity, which requires its histidine residue at the 41st amino acid. Histidine 140-149 dicer 1, ribonuclease III Homo sapiens 68-73 32603918-6 2020 Myosin light chain (MYL1 and MYL3) showed high oxidative susceptibility owing to peptidyl methionine and proline oxidation as well as acetaldehyde adduct formation on lysine or histidine residues. Histidine 177-186 myosin light chain 1 Homo sapiens 20-24 33147004-7 2020 The present research will aid in obtaining insight into the organizational and accumulation properties of tau protein in the presence of histidine tautomerism to control AD. Histidine 137-146 microtubule associated protein tau Homo sapiens 106-109 33057331-1 2020 Diphthamide is a unique post-translationally modified histidine residue (His715 in all mammals) found only in eukaryotic elongation factor-2 (eEF-2). Histidine 54-63 eukaryotic translation elongation factor 2 Homo sapiens 110-140 33057331-1 2020 Diphthamide is a unique post-translationally modified histidine residue (His715 in all mammals) found only in eukaryotic elongation factor-2 (eEF-2). Histidine 54-63 eukaryotic translation elongation factor 2 Homo sapiens 142-147 33101590-10 2020 Rh-CSF1 treatment significantly attenuated neurological deficits, infarct volume, OS, neuronal apoptosis, and degeneration at 48 h after HI. Histidine 137-139 colony stimulating factor 1 Homo sapiens 3-7 33101590-13 2020 These results suggested that rh-CSF1 treatment attenuated OS-induced neuronal degeneration and apoptosis after HI, at least in part, through the CSF1R/PLCG2/PKA/UCP2 signaling pathway. Histidine 111-113 colony stimulating factor 1 Homo sapiens 32-36 33000160-4 2020 In mammals, l-histidine is rapidly incorporated into epidermal FLG and subsequent FLG proteolysis releases l-histidine as an important natural moisturizing factor (NMF). Histidine 12-23 filaggrin Homo sapiens 63-66 33000160-4 2020 In mammals, l-histidine is rapidly incorporated into epidermal FLG and subsequent FLG proteolysis releases l-histidine as an important natural moisturizing factor (NMF). Histidine 12-23 filaggrin Homo sapiens 82-85 33000160-4 2020 In mammals, l-histidine is rapidly incorporated into epidermal FLG and subsequent FLG proteolysis releases l-histidine as an important natural moisturizing factor (NMF). Histidine 107-118 filaggrin Homo sapiens 82-85 33000160-5 2020 It has therefore been hypothesized that l-histidine supplementation would be a safe approach to augment both FLG and the NMF, enhance skin barrier function, and reduce AD severity. Histidine 40-51 filaggrin Homo sapiens 109-112 32808171-4 2020 To accomplish this, the codon-optimized 1507 bp coding sequence of the human ETS2 gene in fusion with a His-tag, a cell-penetrating peptide, and a nuclear localization sequence was cloned in the protein expression vector and transformed into E. coli strain BL21(DE3) for expression. Histidine 104-107 ETS proto-oncogene 2, transcription factor Homo sapiens 77-81 32877466-6 2020 Here we produced His-tagged domain 11 (D11), an IGF2-binding element of IGF2R; we immobilized it on the solid support through a well-defined sandwich, consisting of neutravidin, biotin and synthetic anti-His-tag antibodies. Histidine 17-20 insulin like growth factor 2 receptor Homo sapiens 48-52 32877466-6 2020 Here we produced His-tagged domain 11 (D11), an IGF2-binding element of IGF2R; we immobilized it on the solid support through a well-defined sandwich, consisting of neutravidin, biotin and synthetic anti-His-tag antibodies. Histidine 17-20 insulin like growth factor 2 receptor Homo sapiens 72-77 32579975-5 2020 Only when PD-1 interacts with PD-L1 did the FSY react with a proximal histidine of PD-L1 selectively, enabling irreversible binding of PD-1 to only PD-L1 in vitro and in vivo. Histidine 70-79 CD274 molecule Homo sapiens 83-88 32029268-4 2020 The oriented immobilization of PNGase F on magnetic particles utilizes the affinity of its co-expressed His-tag towards iminodiacetic acid-Nickel modified magnetic particles. Histidine 104-107 N-glycanase 1 Homo sapiens 31-37 32392205-5 2020 The differential specificity of ligands to BLT1 and BLT2 is explained by the replacement of histidine with tyrosine. Histidine 92-101 leukotriene B4 receptor 2 Homo sapiens 52-56 31820933-4 2020 The histidine residues contained in these fragments are potential binding sites for metal ions and are located close to the regions that drive the formation of amyloid aggregates of tau. Histidine 4-13 microtubule associated protein tau Homo sapiens 182-185 31639017-2 2019 The common features of MCPIP proteins are the zinc finger domain, consisting of three cysteines and one histidine (CCCH), and the N-terminal domain of the PilT protein (PilT-N-terminal domain (PIN domain)). Histidine 104-113 zinc finger CCCH-type containing 12A Homo sapiens 23-28 31351182-6 2019 Furthermore, one residue located at 10 A distance from the catalytic site is different between the sub-families but highly conserved within each sub-family (Asp in AOC1, His in AOC2, Thr in AOC3 and Asn in AOC4) and likely contributes to substrate selectivity. Histidine 170-173 amine oxidase copper containing 2 Homo sapiens 177-181 31384872-3 2019 Here, we report that the presence of a composite non-ELP sequence that includes both His and T7 tags or a short Ser-Lys-Gly-Pro-Gly (SKGPG) sequence can dramatically change the LCST behavior of a positively-charged ELP domain. Histidine 85-88 nuclear receptor subfamily 5 group A member 1 Homo sapiens 53-56 31384872-3 2019 Here, we report that the presence of a composite non-ELP sequence that includes both His and T7 tags or a short Ser-Lys-Gly-Pro-Gly (SKGPG) sequence can dramatically change the LCST behavior of a positively-charged ELP domain. Histidine 85-88 nuclear receptor subfamily 5 group A member 1 Homo sapiens 215-218 31463593-1 2019 Diphthamide, the target of diphtheria toxin, is a post-translationally modified histidine residue found in archaeal and eukaryotic translation elongation factor 2 (EF2). Histidine 80-89 eukaryotic translation elongation factor 2 Homo sapiens 120-162 31463593-1 2019 Diphthamide, the target of diphtheria toxin, is a post-translationally modified histidine residue found in archaeal and eukaryotic translation elongation factor 2 (EF2). Histidine 80-89 eukaryotic translation elongation factor 2 Homo sapiens 164-167 31032878-8 2019 Low sensitivity of Kv 12.1 and characteristics of quinine-dependent inhibition were determined by histidine 462, as site-directed mutagenesis of this residue into the homologous tyrosine of Kv 11.1 conferred Kv 11.1-like quinine block to Kv 12.1(H462Y). Histidine 98-107 potassium voltage-gated channel subfamily H member 2 Homo sapiens 190-197 31032878-8 2019 Low sensitivity of Kv 12.1 and characteristics of quinine-dependent inhibition were determined by histidine 462, as site-directed mutagenesis of this residue into the homologous tyrosine of Kv 11.1 conferred Kv 11.1-like quinine block to Kv 12.1(H462Y). Histidine 98-107 potassium voltage-gated channel subfamily H member 2 Homo sapiens 208-215 31150637-3 2019 Positively charged arginine (R) and histidine (H) of mouse AQP0 ELA and ELC were substituted individually with glutamine (Q) to create R33Q, H40Q, R113Q and H122Q by mutagenesis. Histidine 36-45 apelin receptor early endogenous ligand Mus musculus 64-67 31167910-11 2019 Collectively, our data indicate that the essential HBx cysteine and histidine residues form a zinc-binding motif that is required for HBx function.IMPORTANCE The structural maintenance of chromosomes 5/6 complex (Smc5/6) is a host restriction factor that suppresses HBV transcription. Histidine 68-77 X protein Hepatitis B virus 134-137 31220181-3 2019 Crystal structure of A26 protein revealed that His48 and His53 are in close contact with Lys47, Arg57, His314 and Arg312, suggesting that at low pH these His-cation pairs could initiate conformational changes through protonation of His48 and His53 and subsequent electrostatic repulsion. Histidine 47-50 immunoglobulin kappa variable 6-21 (non-functional) Homo sapiens 21-24 31223255-5 2019 Filaggrin is a multifunctional, histidine-rich, insoluble protein. Histidine 32-41 filaggrin Homo sapiens 0-9 30826286-13 2019 Furthermore, a specific residue difference between CRFR1 subtypes (glutamate) and CRFR2beta (histidine) in this interface region may impair CRFR2beta:RAMP2 interaction by electrostatic repulsion. Histidine 93-102 receptor activity modifying protein 2 Homo sapiens 150-155 31149044-8 2019 Though BAP2 contains a weak Michael acceptor, interaction with PDI relies on Histidine 256 in the b" domain of PDI, suggesting allosteric binding. Histidine 77-86 prolyl 4-hydroxylase, beta polypeptide Mus musculus 63-66 31149044-8 2019 Though BAP2 contains a weak Michael acceptor, interaction with PDI relies on Histidine 256 in the b" domain of PDI, suggesting allosteric binding. Histidine 77-86 prolyl 4-hydroxylase, beta polypeptide Mus musculus 111-114 30931977-0 2019 The protonation state of an evolutionarily conserved histidine modulates domainswapping stability of FoxP1. Histidine 53-62 forkhead box P1 Homo sapiens 101-106 30931977-5 2019 Here, we explore the consequences of the protonation state of another histidine (H59), only conserved within FoxM/O/P subfamilies, on folding and dimerization of the forkhead domain of human FoxP1. Histidine 70-79 forkhead box P1 Homo sapiens 191-196 30842276-3 2019 We demonstrate that mda-7/IL-24, administered through a replication incompetent type 5 adenovirus (Ad.mda-7) or with His-MDA-7/IL-24 protein, down-regulates DICER, a critical regulator in miRNA processing. Histidine 117-120 interleukin 24 Homo sapiens 20-25 30842276-3 2019 We demonstrate that mda-7/IL-24, administered through a replication incompetent type 5 adenovirus (Ad.mda-7) or with His-MDA-7/IL-24 protein, down-regulates DICER, a critical regulator in miRNA processing. Histidine 117-120 interleukin 24 Homo sapiens 26-31 30842276-3 2019 We demonstrate that mda-7/IL-24, administered through a replication incompetent type 5 adenovirus (Ad.mda-7) or with His-MDA-7/IL-24 protein, down-regulates DICER, a critical regulator in miRNA processing. Histidine 117-120 interleukin 24 Homo sapiens 121-126 30842276-3 2019 We demonstrate that mda-7/IL-24, administered through a replication incompetent type 5 adenovirus (Ad.mda-7) or with His-MDA-7/IL-24 protein, down-regulates DICER, a critical regulator in miRNA processing. Histidine 117-120 interleukin 24 Homo sapiens 127-132 30842276-3 2019 We demonstrate that mda-7/IL-24, administered through a replication incompetent type 5 adenovirus (Ad.mda-7) or with His-MDA-7/IL-24 protein, down-regulates DICER, a critical regulator in miRNA processing. Histidine 117-120 dicer 1, ribonuclease III Homo sapiens 157-162 30598506-3 2019 Here, using immunoprecipitation, subcellular fractionation, His-ubiquitin pulldown, and immunofluorescence microscopy assays, along with siRNA-based knockdown approaches, we demonstrate that ribosomal protein L6 (RPL6) directly interacts with histone H2A and is involved in the DNA damage response (DDR). Histidine 60-63 ribosomal protein L6 Homo sapiens 191-211 30396406-2 2019 Therefore, the cost-effective production of Saccharomyces cerevisiae Ulp1 protease catalytic domain (402-621 aa) was targeted via its cloning under strong T7 promoter with and without histidine tag. Histidine 184-193 SUMO protease ULP1 Saccharomyces cerevisiae S288C 69-73 30422655-0 2018 Copper Induced Radical Dimerization of alpha-Synuclein Requires Histidine. Histidine 64-73 synuclein alpha Homo sapiens 39-54 30251657-7 2018 NMR data demonstrate that the recombinant domains of THB2 and THB4 coordinate the ferrous heme iron with the proximal histidine and a lysine from the distal helix. Histidine 118-127 uncharacterized protein Chlamydomonas reinhardtii 53-57 29923593-3 2018 In the present study, the histopathological effect of 200 and 1000 mg/kg of HI methanolic stem bark extract (HlMeOHe) was evaluated in the small bowel, liver, pancreas, kidneys and brain of CD-1 male mice after oral sub-acute treatment for 28 days. Histidine 76-78 CD1 antigen complex Mus musculus 190-194 29148316-0 2018 Recognition dynamics of trinuclear copper cluster and associated histidine residues through conserved or semi-conserved water molecules in human Ceruloplasmin: The involvement of aspartic and glutamic acid gates. Histidine 65-74 ceruloplasmin Homo sapiens 145-158 30054272-4 2018 The mutation causes a substitution of a glutamine residue that is highly conserved in the extracellular S1-S2 loop of domain II in all Cav channels with a histidine and was identified by whole-exome sequencing of an individual with moderate hearing impairment, developmental delay, and epilepsy. Histidine 155-164 caveolin 2 Homo sapiens 135-138 30048132-3 2018 To better understand ligand-transporter interactions that could improve potency, we developed structural LAT1 models to guide the design of substituted analogues of phenylalanine and histidine. Histidine 183-192 solute carrier family 7 member 5 Homo sapiens 105-109 29635803-11 2018 In contrast, HI decreased AMPK activation in both cell lines, whereas it increased ERK1/2 levels in PNT1A and decreased them in PC3 (reflecting greater cell proliferation only in non-tumor cells). Histidine 13-15 chromobox 8 Homo sapiens 128-131 29718430-14 2018 Plasma Ile, Leu, and Val were lower, and plasma His was greater in +LPS than -LPS steers (LPS, P < 0.05). Histidine 48-51 interferon regulatory factor 6 Homo sapiens 78-81 29718430-14 2018 Plasma Ile, Leu, and Val were lower, and plasma His was greater in +LPS than -LPS steers (LPS, P < 0.05). Histidine 48-51 interferon regulatory factor 6 Homo sapiens 78-81 29914368-3 2018 The ribosomal oxygenases RIOX1 (NO66) and RIOX2 (MINA53) modify ribosomal proteins by histidine hydroxylation. Histidine 86-95 ribosomal oxygenase 2 Homo sapiens 49-55 29849110-3 2018 In this research we report a FRalpha binding peptide C7(Met-His-Thr-Ala-Pro-Gly-Trp-Gly-Tyr-Arg-Leu-Ser) discovered by phage display and this peptide showed specific binding to FRalpha expressing cells by cell ELISA and flow cytometry. Histidine 60-63 FOS like 1, AP-1 transcription factor subunit Homo sapiens 177-184 29402466-3 2018 Most of vertebrate CTR1 proteins contain the His residue in position three from N-terminus, creating a well-known Amino Terminal Cu(II)- and Ni(II)-Binding (ATCUN) site. Histidine 45-48 solute carrier family 31 member 1 Homo sapiens 19-23 29402466-4 2018 CTR1 from humans, primates and many other species contains the Met-Asp-His (MDH) sequence, while some rodents including mouse have the Met-Asn-His (MNH) N-terminal sequence. Histidine 71-74 solute carrier family 31 member 1 Homo sapiens 0-4 29896284-5 2018 Gene set enrichment analysis showed that the high-risk group with lower expression levels of the three genes was enriched in bladder cancer and cell cycle pathway, whereas the low-risk group with higher expression levels of the three genes was enriched in drug metabolism-cytochrome P450, PPAR signaling pathway, fatty acid and histidine metabolisms. Histidine 328-337 peroxisome proliferator activated receptor alpha Homo sapiens 289-293 29287303-6 2018 Recombinant His-tagged full-length DEK protein (1-375 amino acids [aa]) and the 187-375-aa and 1-350-aa His-tagged DEK fragments made in a baculovirus system were used for enzyme-linked immunosorbent assay (ELISA) and immunoblotting. Histidine 12-15 DEK proto-oncogene Homo sapiens 35-38 29590114-6 2018 The c.2510G>A transition variant is predicted to substitute a highly invariant arginine residue with histidine (p.Arg837His) in the phosphatase domain of PPIP5K2. Histidine 104-113 diphosphoinositol pentakisphosphate kinase 2 Mus musculus 157-164 29480716-4 2018 We have engineered histidine into highly solvent accessible positions of UBA(2), creating six single histidine variants. Histidine 19-28 ubiquitin like modifier activating enzyme 2 Homo sapiens 73-78 29480716-4 2018 We have engineered histidine into highly solvent accessible positions of UBA(2), creating six single histidine variants. Histidine 101-110 ubiquitin like modifier activating enzyme 2 Homo sapiens 73-78 29480716-6 2018 Furthermore, engineered histidine residues in UBA(2) strongly destabilize the iso-1-cytochrome c domain. Histidine 24-33 ubiquitin like modifier activating enzyme 2 Homo sapiens 46-51 29237553-8 2018 However, IL-11 R112H fails to support the survival of osteoclast progenitor cells and is less thermally stable, which is caused by the loss of the positive charge on the protein surface since protonation of the histidine side chain recovers stability. Histidine 211-220 interleukin 11 Homo sapiens 9-14 29224352-1 2018 The proton-coupled oligopeptide transporter PHT1 (SLC15A4), which facilitates cross-membrane transport of histidine and small peptides from inside the endosomes or lysosomes to cytosol, plays an important role in intracellular peptides homeostasis and innate immune responses. Histidine 106-115 solute carrier family 15 member 4 Homo sapiens 44-48 29224352-1 2018 The proton-coupled oligopeptide transporter PHT1 (SLC15A4), which facilitates cross-membrane transport of histidine and small peptides from inside the endosomes or lysosomes to cytosol, plays an important role in intracellular peptides homeostasis and innate immune responses. Histidine 106-115 solute carrier family 15 member 4 Homo sapiens 50-57 29387685-3 2017 The Hsp90-mediated activation of NLR receptors (Nucleotide-binding domain and Leucine-rich Repeat) in the innate immunity of both plants and animals is dependent on the co-chaperone Sgt1 and in plants on Rar1, a cysteine- and histidine-rich domain (CHORD)-containing protein. Histidine 226-235 heat shock protein 90 alpha family class A member 1 Homo sapiens 4-9 29218639-3 2018 In this work, we examine two of such His-rich regions from forkhead box and MAFA proteins-MB3 (contains 18 His) and MB6 (with 21 His residues), focusing on the affinity and binding modes of Cu2+ and Zn2+ towards the two His-rich regions. Histidine 37-40 MAF bZIP transcription factor A Homo sapiens 76-80 29218639-3 2018 In this work, we examine two of such His-rich regions from forkhead box and MAFA proteins-MB3 (contains 18 His) and MB6 (with 21 His residues), focusing on the affinity and binding modes of Cu2+ and Zn2+ towards the two His-rich regions. Histidine 107-110 MAF bZIP transcription factor A Homo sapiens 76-80 29218639-3 2018 In this work, we examine two of such His-rich regions from forkhead box and MAFA proteins-MB3 (contains 18 His) and MB6 (with 21 His residues), focusing on the affinity and binding modes of Cu2+ and Zn2+ towards the two His-rich regions. Histidine 107-110 MAF bZIP transcription factor A Homo sapiens 76-80 29218639-3 2018 In this work, we examine two of such His-rich regions from forkhead box and MAFA proteins-MB3 (contains 18 His) and MB6 (with 21 His residues), focusing on the affinity and binding modes of Cu2+ and Zn2+ towards the two His-rich regions. Histidine 107-110 MAF bZIP transcription factor A Homo sapiens 76-80 29027595-1 2018 Carnosinase (CN1) is a dipeptidase, encoded by the CNDP1 gene, that degrades histidine-containing dipeptides, such as carnosine, anserine and homocarnosine. Histidine 77-86 carnosine dipeptidase 1 Homo sapiens 13-16 29027595-1 2018 Carnosinase (CN1) is a dipeptidase, encoded by the CNDP1 gene, that degrades histidine-containing dipeptides, such as carnosine, anserine and homocarnosine. Histidine 77-86 carnosine dipeptidase 1 Homo sapiens 51-56 28942838-2 2017 In addition to its fundamental role in nucleotide metabolism, Ndk has roles in protein histidine phosphorylation, DNA cleavage/repair, and gene regulation. Histidine 87-96 cytidine/uridine monophosphate kinase 2 Homo sapiens 62-65 29162828-7 2017 Epitope mapping reveals that AE2 recognizes a region of human SeP adjacent to the first histidine-rich region (FHR). Histidine 88-97 solute carrier family 4 member 2 Homo sapiens 29-32 29226085-0 2017 Cysteine and histidine residues are involved in Escherichia coli Tn21 MerE methylmercury transport. Histidine 13-22 MerE Escherichia coli 70-74 28709952-4 2017 Inhibition was tested on the antiport catalysed by hLAT1 as transport of extraliposomal [3H]histidine in exchange with intraliposomal histidine. Histidine 92-101 solute carrier family 7 member 5 Homo sapiens 51-56 28709952-4 2017 Inhibition was tested on the antiport catalysed by hLAT1 as transport of extraliposomal [3H]histidine in exchange with intraliposomal histidine. Histidine 134-143 solute carrier family 7 member 5 Homo sapiens 51-56 28991911-7 2017 Some haplotypes of IgG3 have histidine at position 435. Histidine 29-38 immunoglobulin heavy constant gamma 3 (G3m marker) Homo sapiens 19-23 29042806-4 2017 In mammalian skin, l-histidine is rapidly incorporated into filaggrin. Histidine 19-30 filaggrin Homo sapiens 60-69 29042806-5 2017 Subsequent filaggrin proteolysis releases l-histidine as an important natural moisturizing factor (NMF). Histidine 42-53 filaggrin Homo sapiens 11-20 29042806-6 2017 In vitro studies were conducted to investigate the influence of l-histidine on filaggrin processing and barrier function in human skin-equivalent models. Histidine 64-75 filaggrin Homo sapiens 79-88 29042806-9 2017 In vitro studies demonstrated that l-histidine significantly increased both filaggrin formation and skin barrier function (P<0.01, respectively). Histidine 35-46 filaggrin Homo sapiens 76-85 29042806-12 2017 The clinical effect of oral l-histidine in AD was similar to that of mid-potency topical corticosteroids and combined with its safety profile suggests that it may be a safe, nonsteroidal approach suitable for long-term use in skin conditions that are associated with filaggrin deficits such as AD. Histidine 28-39 filaggrin Homo sapiens 267-276 28952923-0 2017 A Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1. Histidine 2-11 RAS guanyl releasing protein 1 Homo sapiens 98-105 28724772-2 2017 Two-hybrid and pulldown assays demonstrated that UL20, but no other HSV-1 gene-encoded proteins, binds specifically to GODZ (also known as DHHC3), a cellular Golgi apparatus-specific Asp-His-His-Cys (DHHC) zinc finger protein. Histidine 187-190 zinc finger DHHC-type palmitoyltransferase 3 Homo sapiens 119-123 28425671-6 2017 Importantly, the endogenous proteasomal E3 ligase UBE3C was also successfully labelled by Ub-PA and His-UBE2D2-Ub-ABP in lysate of cells grown under basal conditions. Histidine 100-103 ubiquitin conjugating enzyme E2 D2 Homo sapiens 104-110 28532685-3 2017 The purpose of this paper is to address the inhibition of protein disulfide isomerase (PDI), an essential redox chaperone whose active sites contain the Cys-Gly-His-Cys (CXXC) motif, by the nitroxide Tempol. Histidine 161-164 prolyl 4-hydroxylase, beta polypeptide Mus musculus 58-85 28532685-3 2017 The purpose of this paper is to address the inhibition of protein disulfide isomerase (PDI), an essential redox chaperone whose active sites contain the Cys-Gly-His-Cys (CXXC) motif, by the nitroxide Tempol. Histidine 161-164 prolyl 4-hydroxylase, beta polypeptide Mus musculus 87-90 28644885-10 2017 In addition, we also detected OATP1B3-FLAG co-localization with OATP1B1-His or NTCP-His, suggesting that OATP1B3 also hetero-oligomerizes with other transport proteins. Histidine 72-75 solute carrier organic anion transporter family member 1B1 Homo sapiens 64-71 28387856-0 2017 Involvement of C-Terminal Histidines in Soybean PM1 Protein Oligomerization and Cu2+ Binding. Histidine 26-36 late embryogenesis abundant group 4 protein PM1 Glycine max 48-51 28387856-7 2017 When the histidine residues in PM1 and PM1-C were chemically modified, oligomerization was abolished, suggesting that histidines play a key role in this process. Histidine 9-18 late embryogenesis abundant group 4 protein PM1 Glycine max 31-34 28387856-7 2017 When the histidine residues in PM1 and PM1-C were chemically modified, oligomerization was abolished, suggesting that histidines play a key role in this process. Histidine 9-18 late embryogenesis abundant group 4 protein PM1 Glycine max 39-42 28387856-7 2017 When the histidine residues in PM1 and PM1-C were chemically modified, oligomerization was abolished, suggesting that histidines play a key role in this process. Histidine 118-128 late embryogenesis abundant group 4 protein PM1 Glycine max 31-34 28387856-7 2017 When the histidine residues in PM1 and PM1-C were chemically modified, oligomerization was abolished, suggesting that histidines play a key role in this process. Histidine 118-128 late embryogenesis abundant group 4 protein PM1 Glycine max 39-42 28277678-0 2017 Unravelling the Non-Native Low-Spin State of the Cytochrome c-Cardiolipin Complex: Evidence of the Formation of a His-Ligated Species Only. Histidine 114-117 cytochrome c, somatic Equus caballus 49-61 28328125-1 2017 De novo heterozygous mutations changing R179 to histidine, leucine, or cysteine in the ACTA2 gene are associated with Multisystemic Smooth Muscle Dysfunction Syndrome (MSMDS). Histidine 48-57 actin alpha 2, smooth muscle Homo sapiens 87-92 28349924-5 2017 To understand how this gelsolin fragment is activated for F-actin severing by lowering pH, we solved its NMR structures at both pH 7.3 and 5 in the absence of Ca2+ and measured the pKa values of acidic amino acid residues and histidine residues. Histidine 226-235 gelsolin Homo sapiens 23-31 27940575-3 2017 Either ectopic expression of mda-7/IL-24 or treatment with recombinant His-MDA-7 protein resulted in downregulation of miR-221 and upregulation of p27 and PUMA in a panel of cancer cells, culminating in cell death. Histidine 71-74 interleukin 24 Homo sapiens 75-80 27940575-3 2017 Either ectopic expression of mda-7/IL-24 or treatment with recombinant His-MDA-7 protein resulted in downregulation of miR-221 and upregulation of p27 and PUMA in a panel of cancer cells, culminating in cell death. Histidine 71-74 microRNA 221 Homo sapiens 119-126 27665193-4 2017 The SERS results for BN and its fragment demonstrated that (1) three amino acids from these peptides sequence; i.e., l-histidine, l-methionine, and l-tryptophan, are involved in the interaction with gold coated silicon wafer and (2) the strength of these interactions depends upon the aforementioned amino acids position in the peptide sequence. Histidine 117-128 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 4-8 28125045-3 2017 Here we show the binding of a soluble histidine tagged l-selectin to a recently described shortened variant of an l-selectin specific DNA aptamer with surface plasmon resonance. Histidine 38-47 selectin L Homo sapiens 55-65 28125045-3 2017 Here we show the binding of a soluble histidine tagged l-selectin to a recently described shortened variant of an l-selectin specific DNA aptamer with surface plasmon resonance. Histidine 38-47 selectin L Homo sapiens 114-124 27865840-5 2017 The N-terminal fragment of SSH1 bound to and co-localized with F-actin, but mutation at Arg-96 or a Leu-His-Lys (LHK) motif in the PH-like domain reduced this activity. Histidine 104-107 slingshot protein phosphatase 1 Homo sapiens 27-31 27860283-3 2017 In the present study, we tested whether creation of an endogenous proton antenna by introduction of a cluster of histidine residues into the C-terminal tail of MCT4 (MCT4-6xHis) could facilitate MCT4 transport activity when heterologously expressed in Xenopus oocytes. Histidine 113-122 solute carrier family 16 member 3 S homeolog Xenopus laevis 160-164 27860283-3 2017 In the present study, we tested whether creation of an endogenous proton antenna by introduction of a cluster of histidine residues into the C-terminal tail of MCT4 (MCT4-6xHis) could facilitate MCT4 transport activity when heterologously expressed in Xenopus oocytes. Histidine 113-122 solute carrier family 16 member 3 S homeolog Xenopus laevis 166-176 27860283-3 2017 In the present study, we tested whether creation of an endogenous proton antenna by introduction of a cluster of histidine residues into the C-terminal tail of MCT4 (MCT4-6xHis) could facilitate MCT4 transport activity when heterologously expressed in Xenopus oocytes. Histidine 113-122 solute carrier family 16 member 3 S homeolog Xenopus laevis 166-170 27860283-4 2017 Our results show that integration of six histidines into the C-terminal tail does indeed increase transport activity of MCT4 to the same extent as did coexpression of MCT4-WT with CAII. Histidine 41-51 solute carrier family 16 member 3 Homo sapiens 120-124 27860283-6 2017 Injection of an antibody against the histidine cluster into MCT4-expressing oocytes decreased transport activity of MCT4-6xHis, while leaving activity of MCT4-WT unaltered. Histidine 37-46 solute carrier family 16 member 3 Homo sapiens 60-64 27860283-6 2017 Injection of an antibody against the histidine cluster into MCT4-expressing oocytes decreased transport activity of MCT4-6xHis, while leaving activity of MCT4-WT unaltered. Histidine 37-46 solute carrier family 16 member 3 Homo sapiens 116-126 27860283-6 2017 Injection of an antibody against the histidine cluster into MCT4-expressing oocytes decreased transport activity of MCT4-6xHis, while leaving activity of MCT4-WT unaltered. Histidine 37-46 solute carrier family 16 member 3 Homo sapiens 116-120 27872244-8 2017 The most prominent network-guided GWAS signal was for a histidine (His)-related trait in a region containing two genes: a cationic amino acid transporter (CAT4) and a polynucleotide phosphorylase resistant to inhibition with fosmidomycin. Histidine 56-65 cationic amino acid transporter 4 Arabidopsis thaliana 155-159 27872244-8 2017 The most prominent network-guided GWAS signal was for a histidine (His)-related trait in a region containing two genes: a cationic amino acid transporter (CAT4) and a polynucleotide phosphorylase resistant to inhibition with fosmidomycin. Histidine 67-70 cationic amino acid transporter 4 Arabidopsis thaliana 155-159 27580602-11 2016 In addition, a fused histidine-tagged cecropin b-human epidermal growth factor (CB-EGF) from Escherichia coli crude extract was purified by the Ni(II)-chelated stationary phase, and the purity of the CB-EGF was determined to be at least 90 %. Histidine 21-30 epidermal growth factor Homo sapiens 55-78 27807034-4 2016 CNOT3 interacts with EBF1, and we identified histidine 240 in EBF1 as a critical residue for this interaction. Histidine 45-54 early B cell factor 1 Mus musculus 21-25 27807034-4 2016 CNOT3 interacts with EBF1, and we identified histidine 240 in EBF1 as a critical residue for this interaction. Histidine 45-54 early B cell factor 1 Mus musculus 62-66 29741343-0 2016 [Ubiquitination regulation of histidine transporter Hip1p on histidine utilization in Saccharomyces cerevisiae]. Histidine 30-39 histidine permease Saccharomyces cerevisiae S288C 52-57 27374989-8 2016 We suggest that Dm eIF4E-3 and Dm eIF4E-5 bind the second nucleoside of the cap in an unusual manner via stacking interactions with a histidine or a phenylalanine residue, respectively. Histidine 134-143 eukaryotic translation initiation factor 4E3 Drosophila melanogaster 19-26 27470567-14 2016 Finally, tilianin docking studies with PPARalpha showed polar interactions with Glu269, Tyr314, His 440 and Tyr464 residues. Histidine 96-99 peroxisome proliferator activated receptor alpha Rattus norvegicus 39-48 26510381-3 2016 In this study, we have selected hydroxamic acid derivatives as HDACi and performed fragment-based G-QSAR, molecular docking studies and molecular dynamics simulations for elucidating the dynamic mode of action of HDACi with His-Asp catalytic dyad of HDAC4. Histidine 224-227 histone deacetylase 4 Homo sapiens 250-255 26510381-9 2016 The interaction of the compounds with His-Asp dyad in terms of H-bond interactions with His802, Asp840, Pro942, and Gly975 residues of HDAC4 was evaluated by docking and 20 ns long molecular dynamics simulations. Histidine 38-41 histone deacetylase 4 Homo sapiens 135-140 27553280-8 2016 The peptide/histidine transporter 1 (PHT1) was highly expressed in both myoblasts and myotubes, and co-administration of histidine inhibited Hyp-Gly-induced phosphorylation of p70S6K in myoblasts and myotubes. Histidine 12-21 solute carrier family 15 member 4 Homo sapiens 37-41 27553280-8 2016 The peptide/histidine transporter 1 (PHT1) was highly expressed in both myoblasts and myotubes, and co-administration of histidine inhibited Hyp-Gly-induced phosphorylation of p70S6K in myoblasts and myotubes. Histidine 12-21 ribosomal protein S6 kinase B1 Homo sapiens 176-182 27346274-9 2016 Mutagenesis of each amino acid difference in EC1 between BB3 receptor/BB2 receptor showed replacement of His(107) in BB3 receptor by Lys(107) (H107K-BB3 receptor-mutant) from BB2 receptor, decreased affinity 60-fold, and three replacements [H107K, E11D, G112R] decreased affinity 500-fold. Histidine 105-108 Susceptibility to lysis by alloreactive natural killer cells Homo sapiens 45-48 27453048-2 2016 Here we show that phosphoglycerate mutase family 5 (PGAM5) functions as a phosphohistidine phosphatase that specifically associates with and dephosphorylates the catalytic histidine on nucleoside diphosphate kinase B (NDPK-B). Histidine 81-90 PGAM family member 5, mitochondrial serine/threonine protein phosphatase Homo sapiens 18-50 27453048-2 2016 Here we show that phosphoglycerate mutase family 5 (PGAM5) functions as a phosphohistidine phosphatase that specifically associates with and dephosphorylates the catalytic histidine on nucleoside diphosphate kinase B (NDPK-B). Histidine 81-90 PGAM family member 5, mitochondrial serine/threonine protein phosphatase Homo sapiens 52-57 27453048-2 2016 Here we show that phosphoglycerate mutase family 5 (PGAM5) functions as a phosphohistidine phosphatase that specifically associates with and dephosphorylates the catalytic histidine on nucleoside diphosphate kinase B (NDPK-B). Histidine 81-90 NME/NM23 nucleoside diphosphate kinase 2 Homo sapiens 185-216 27453048-2 2016 Here we show that phosphoglycerate mutase family 5 (PGAM5) functions as a phosphohistidine phosphatase that specifically associates with and dephosphorylates the catalytic histidine on nucleoside diphosphate kinase B (NDPK-B). Histidine 81-90 NME/NM23 nucleoside diphosphate kinase 2 Homo sapiens 218-224 27453048-3 2016 By dephosphorylating NDPK-B, PGAM5 negatively regulates CD4(+) T cells by inhibiting NDPK-B-mediated histidine phosphorylation and activation of the K(+) channel KCa3.1, which is required for TCR-stimulated Ca(2+) influx and cytokine production. Histidine 101-110 NME/NM23 nucleoside diphosphate kinase 2 Homo sapiens 21-27 27453048-3 2016 By dephosphorylating NDPK-B, PGAM5 negatively regulates CD4(+) T cells by inhibiting NDPK-B-mediated histidine phosphorylation and activation of the K(+) channel KCa3.1, which is required for TCR-stimulated Ca(2+) influx and cytokine production. Histidine 101-110 PGAM family member 5, mitochondrial serine/threonine protein phosphatase Homo sapiens 29-34 27453048-3 2016 By dephosphorylating NDPK-B, PGAM5 negatively regulates CD4(+) T cells by inhibiting NDPK-B-mediated histidine phosphorylation and activation of the K(+) channel KCa3.1, which is required for TCR-stimulated Ca(2+) influx and cytokine production. Histidine 101-110 NME/NM23 nucleoside diphosphate kinase 2 Homo sapiens 85-91 27380437-3 2016 Histidine and citrate buffers with/without sodium chloride were employed to modulate the mAb"s conformational stability, solubility (in the presence of polyethylene glycol, PEG), and protein-protein interactions as measured by differential scanning calorimetry, PEG precipitation, and static light scattering, respectively. Histidine 0-9 progestagen associated endometrial protein Homo sapiens 173-176 27380437-3 2016 Histidine and citrate buffers with/without sodium chloride were employed to modulate the mAb"s conformational stability, solubility (in the presence of polyethylene glycol, PEG), and protein-protein interactions as measured by differential scanning calorimetry, PEG precipitation, and static light scattering, respectively. Histidine 0-9 progestagen associated endometrial protein Homo sapiens 262-265 27467577-3 2016 Recently, specific non-conserved histidines on human TLR4 have been shown activated by cobalt and nickel ions in solution. Histidine 33-43 toll like receptor 4 Homo sapiens 53-57 27414641-0 2016 A Cytolethal Distending Toxin Variant from Aggregatibacter actinomycetemcomitans with an Aberrant CdtB That Lacks the Conserved Catalytic Histidine 160. Histidine 138-147 corneal dystrophy of Bowman's layer type II (Thiel-Behnke) Homo sapiens 98-102 28164627-1 2016 BACKGROUND: Fragile histidine triad (FHIT), fibronectin (FN), and phosphatase and tensin homology deleted on chromosome ten (PTEN) are widely reported as having abnormal expression in malignant tumors. Histidine 20-29 phosphatase and tensin homolog Homo sapiens 125-129 27239044-4 2016 Histamine reduction is most likely caused by increased catabolism of the histamine precursor histidine, triggered by rerouting of alanine flux from AGT to the glutamic-pyruvate transaminase (GPT, also known as the alanine-transaminase ALT). Histidine 93-102 alanine--glyoxylate and serine--pyruvate aminotransferase Homo sapiens 148-151 27239044-5 2016 Alanine administration reduces histamine levels in wild-type mice, while overexpression of GPT in PH1 mice increases plasma histidine, normalizes histamine levels, restores vascular permeability, and decreases urinary oxalate levels. Histidine 124-133 glutamic pyruvic transaminase, soluble Mus musculus 91-94 27239044-5 2016 Alanine administration reduces histamine levels in wild-type mice, while overexpression of GPT in PH1 mice increases plasma histidine, normalizes histamine levels, restores vascular permeability, and decreases urinary oxalate levels. Histidine 124-133 alanine--glyoxylate and serine--pyruvate aminotransferase Homo sapiens 98-101 27082999-7 2016 We constructed two express vector pET28a-His-Hsp65-6P277 and pET28a-His-Hsp65-6IA2P2. Histidine 41-44 heat shock protein 1 (chaperonin) Mus musculus 45-50 27082999-7 2016 We constructed two express vector pET28a-His-Hsp65-6P277 and pET28a-His-Hsp65-6IA2P2. Histidine 68-71 heat shock protein 1 (chaperonin) Mus musculus 72-77 27082999-10 2016 In conclusion, we suggested that fusion protein His-Hsp65-6IA2P2 could be reconstructed and purified successively. Histidine 48-51 heat shock protein 1 (chaperonin) Mus musculus 52-57 26476866-8 2016 In addition to these we have also observed a significant binding site for l-histidine and histidyl moieties at Fab region of IgG. Histidine 74-85 FA complementation group B Homo sapiens 111-114 26826131-1 2016 Rpl3, a highly conserved ribosomal protein, is methylated at histidine 243 by the Hpm1 methyltransferase in Saccharomyces cerevisiae. Histidine 61-70 protein-histidine N-methyltransferase Saccharomyces cerevisiae S288C 82-86 26927547-3 2016 The fragment containing Oct4 gene, amplified by reverse transcription PCR (RT-PCR) from human HeLa cell cDNA as the template, was subcloned into pET-22b(+) and pcDNA3.1(+) vectors to construct the gene recombinant prokaryotic expression vector pET-22b(+)-Oct4 and eukaryotic expression vector pcDNA3.1(+)-his-Oct4, respectively. Histidine 305-308 POU class 5 homeobox 1 Homo sapiens 24-28 26927547-5 2016 The prokaryotic expression vector pET-22b(+)-Oct4 and eukaryotic expression vector pcDNA3.1(+)- his-Oct4 from the positive clones were respectively transformed into E.coli BL21 (DE3) and the embryo HEK293T cells for protein expression. Histidine 96-99 POU class 5 homeobox 1 Homo sapiens 100-104 26778000-0 2016 His-87 ligand in mitoNEET is crucial for the transfer of iron sulfur clusters from mitochondria to cytosolic aconitase. Histidine 0-3 CDGSH iron sulfur domain 1 Homo sapiens 17-25 26778000-4 2016 Our results confirm the observation that mitoNEET is important in transferring the iron sulfur clusters to the cytosolic aconitase in living cells and the His-87 ligand in mitoNEET plays important role in this process. Histidine 155-158 CDGSH iron sulfur domain 1 Homo sapiens 41-49 26778000-4 2016 Our results confirm the observation that mitoNEET is important in transferring the iron sulfur clusters to the cytosolic aconitase in living cells and the His-87 ligand in mitoNEET plays important role in this process. Histidine 155-158 CDGSH iron sulfur domain 1 Homo sapiens 172-180 27524954-6 2016 Our findings suggest that insertion of a His-tag at the N-terminal or C-terminal end of ZNF191(243-368) has different effects on the protein. Histidine 41-44 zinc finger protein 24 Homo sapiens 88-94 26881185-2 2016 Due to the presence of the recognition unit GGH (Gly-Gly-His), the probe C-GGH can coordinate with Cu(2+) and consequently display ON-OFF type fluorescence response. Histidine 57-60 gamma-glutamyl hydrolase Homo sapiens 44-47 26881185-2 2016 Due to the presence of the recognition unit GGH (Gly-Gly-His), the probe C-GGH can coordinate with Cu(2+) and consequently display ON-OFF type fluorescence response. Histidine 57-60 gamma-glutamyl hydrolase Homo sapiens 75-78 27631796-5 2016 We describe the bacterial expression and purification of all complex components, namely an 86 kDa His-tagged RanBP2 fragment, the SUMO E2-conjugating enzyme Ubc9, RanGAP1, and SUMO1, and we provide a protocol for quantitative SUMOylation of RanGAP1. Histidine 98-101 RAN binding protein 2 Homo sapiens 109-115 25923177-12 2015 A shampoo and conditioner containing chelants (EDDS in shampoo and histidine in conditioner) is shown to reduce copper uptake from tap water and reduce protein loss and formation of S100A3 protein fragment. Histidine 67-76 S100 calcium binding protein A3 Homo sapiens 182-188 26282237-5 2015 Current amplitudes were voltage dependent, strongly potentiated in oocytes preinjected with ascorbate (the canonical electron donor for cytochrome b561), and abolished by mutating a highly conserved His residue (H292L) predicted to coordinate the cytoplasmic heme b group. Histidine 199-202 cytochrome b561 Homo sapiens 136-151 26195630-6 2015 In contrast, mutations in the C-terminal hinge-cysteine-histidine-rich domain segment primarily affected the PCSK9-induced CD81 degradation. Histidine 56-65 proprotein convertase subtilisin/kexin type 9 Homo sapiens 109-114 26195630-7 2015 Furthermore, when C-terminally fused to an ACE2 transmembrane anchor, the secretory N-terminal catalytic or hinge-cysteine-histidine-rich domain domains of PCSK9 were able to reduce CD81 and LDLR levels. Histidine 123-132 proprotein convertase subtilisin/kexin type 9 Homo sapiens 156-161 26195630-7 2015 Furthermore, when C-terminally fused to an ACE2 transmembrane anchor, the secretory N-terminal catalytic or hinge-cysteine-histidine-rich domain domains of PCSK9 were able to reduce CD81 and LDLR levels. Histidine 123-132 low density lipoprotein receptor Homo sapiens 191-195 26337119-6 2015 The imidazole ring of L-Histidine captures the Cd ions from the solution, and prevents the growth of the CdS nanoparticles. Histidine 22-33 CDP-diacylglycerol synthase 1 Homo sapiens 105-108 26337119-7 2015 Furthermore, the photocatalytic contrast experiments illustrate that the as-synthesized flower-like CdS with L-Histidine is more stable than CdS without L-Histidine in the hydrogen generation. Histidine 109-120 CDP-diacylglycerol synthase 1 Homo sapiens 100-103 26337119-7 2015 Furthermore, the photocatalytic contrast experiments illustrate that the as-synthesized flower-like CdS with L-Histidine is more stable than CdS without L-Histidine in the hydrogen generation. Histidine 153-164 CDP-diacylglycerol synthase 1 Homo sapiens 100-103 26232532-4 2015 ZDHHC17 is a member of the DHHC (Asp-His-His-Cys)-containing family, a family of highly homologous proteins. Histidine 37-40 zinc finger DHHC-type palmitoyltransferase 17 Rattus norvegicus 0-7 26226559-0 2015 Allosteric Breakage of the Hydrogen Bond within the Dual-Histidine Motif in the Active Site of Human Pin1 PPIase. Histidine 57-66 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 Homo sapiens 101-105 26226559-6 2015 Here, C113A and C113S Pin1 mutants were found to alter the protonation states of H59 according to the respective residue type replaced at C113, and the mutations resulted in disruption of the hydrogen bond within the dual-histidine motif. Histidine 222-231 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 Homo sapiens 22-26 26095028-1 2015 Imidazoleglycerol-phosphate dehydratase (IGPD) catalyzes the Mn(II)-dependent dehydration of imidazoleglycerol phosphate (IGP) to 3-(1H-imidazol-4-yl)-2-oxopropyl dihydrogen phosphate during biosynthesis of histidine. Histidine 207-216 imidazoleglycerol-phosphate dehydratase Arabidopsis thaliana 0-39 26273845-1 2015 This work outlines the synthesis of a non-emissive, cyclometalated Ir(III) complex, Ir(ppy)2(H2O)2(+) (Ir1), which elicits a rapid, long-lived phosphorescent signal when coordinated to a histidine-containing protein immobilized on the surface of a magnetic particle. Histidine 187-196 nischarin Homo sapiens 103-106 26035384-3 2015 The interaction with iron is likely to be important in the dimerisation of Abeta and is mediated by three N-terminal histidines. Histidine 117-127 beta amyloid protein precursor-like Drosophila melanogaster 75-80 25977460-14 2015 (111)In-JVZ007-c-myc-his and (111)In-JVZ007-cys internalized in LNCaP cells and bound to PSMA-expressing PDXs and, importantly, not to PSMA-negative PDXs and human kidneys. Histidine 21-24 MYC proto-oncogene, bHLH transcription factor Homo sapiens 15-20 25977460-17 2015 The replacement of the c-myc-his tag by the cysteine contributed to a further reduction of renal uptake without loss of targeting. Histidine 29-32 MYC proto-oncogene, bHLH transcription factor Homo sapiens 23-28 25863146-6 2015 Domain 5 of CI-MPR was expressed in Escherichia coli BL21 (DE3) cells as a fusion protein containing an N-terminal histidine tag and the small ubiquitin-like modifier (SUMO) protein. Histidine 115-124 insulin like growth factor 2 receptor Homo sapiens 12-18 25766873-0 2015 The role of His-83 of yeast apurinic/apyrimidinic endonuclease Apn1 in catalytic incision of abasic sites in DNA. Histidine 12-15 DNA-(apurinic or apyrimidinic site) lyase APN1 Saccharomyces cerevisiae S288C 63-67 25766873-3 2015 Based on its high amino acid homology to Escherichia coli Endo IV, His-83 is believed to coordinate one of three Zn2+ ions in Apn1"s active site similar to His-69 in Endo IV. Histidine 67-70 DNA-(apurinic or apyrimidinic site) lyase APN1 Saccharomyces cerevisiae S288C 126-130 25766873-3 2015 Based on its high amino acid homology to Escherichia coli Endo IV, His-83 is believed to coordinate one of three Zn2+ ions in Apn1"s active site similar to His-69 in Endo IV. Histidine 156-159 DNA-(apurinic or apyrimidinic site) lyase APN1 Saccharomyces cerevisiae S288C 126-130 25980580-2 2015 To test the hypothesis that IDH1 mutations could generate metabolic vulnerabilities for therapeutic intervention, we utilized an MCF10A cell line engineered with an arginine-to-histidine conversion at position 132 (R132H) in the catalytic site of IDH1, which equips the enzyme with a neomorphic alpha-ketoglutarate to 2HG reducing activity in an otherwise isogenic background. Histidine 177-186 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 28-32 25923690-5 2015 Overall, the pooled results indicated that the EPHX1 Tyr113His polymorphism was significantly associated with increased HNC risk (Tyr/His vs. Tyr/Tyr, OR = 1.26, 95%1.02-1.57;His/His+ Tyr/His vs. Tyr/Tyr, OR = 1.29, 95% I = 1.03-1.61). Histidine 59-62 epoxide hydrolase 1 Homo sapiens 47-52 25923690-5 2015 Overall, the pooled results indicated that the EPHX1 Tyr113His polymorphism was significantly associated with increased HNC risk (Tyr/His vs. Tyr/Tyr, OR = 1.26, 95%1.02-1.57;His/His+ Tyr/His vs. Tyr/Tyr, OR = 1.29, 95% I = 1.03-1.61). Histidine 134-137 epoxide hydrolase 1 Homo sapiens 47-52 25923690-5 2015 Overall, the pooled results indicated that the EPHX1 Tyr113His polymorphism was significantly associated with increased HNC risk (Tyr/His vs. Tyr/Tyr, OR = 1.26, 95%1.02-1.57;His/His+ Tyr/His vs. Tyr/Tyr, OR = 1.29, 95% I = 1.03-1.61). Histidine 134-137 epoxide hydrolase 1 Homo sapiens 47-52 25923690-5 2015 Overall, the pooled results indicated that the EPHX1 Tyr113His polymorphism was significantly associated with increased HNC risk (Tyr/His vs. Tyr/Tyr, OR = 1.26, 95%1.02-1.57;His/His+ Tyr/His vs. Tyr/Tyr, OR = 1.29, 95% I = 1.03-1.61). Histidine 134-137 epoxide hydrolase 1 Homo sapiens 47-52 25689174-0 2015 A novel synthetic derivative of melatonin, 5-hydroxy-2"-isobutyl-streptochlorin (HIS), inhibits inflammatory responses via regulation of TRIF-dependent signaling and inflammasome activation. Histidine 81-84 toll-like receptor adaptor molecule 1 Mus musculus 137-141 25689174-9 2015 Mechanistic studies revealed that the inhibitory effects of HIS were mediated through the regulation of the TIR domain-containing, adaptor-inducing, interferon-beta (TRIF)-dependent signaling pathway from toll-like receptors. Histidine 60-63 toll-like receptor adaptor molecule 1 Mus musculus 108-164 25689174-9 2015 Mechanistic studies revealed that the inhibitory effects of HIS were mediated through the regulation of the TIR domain-containing, adaptor-inducing, interferon-beta (TRIF)-dependent signaling pathway from toll-like receptors. Histidine 60-63 toll-like receptor adaptor molecule 1 Mus musculus 166-170 25760390-2 2015 C-terminal His extension of dap (L = 2GH) instead of Gly (L = 3G) lowers the pKa for Cu(III)H-2L (9.36 vs. 9.98) and improves the TOF at pH 11 (53 vs. 24 s(-1)). Histidine 11-14 FEZ family zinc finger 2 Homo sapiens 130-133 25803856-2 2015 This activation is due to the coordination of nickel by a cluster of histidine residues on the ectodomain of human TLR4, which is absent in most other species. Histidine 69-78 toll like receptor 4 Homo sapiens 115-119 25803856-6 2015 Activation of TLR4 by cobalt required MD-2 and was abolished by human TLR4 mutations of histidine residues at positions 456 and 458. Histidine 88-97 toll like receptor 4 Homo sapiens 14-18 25803856-6 2015 Activation of TLR4 by cobalt required MD-2 and was abolished by human TLR4 mutations of histidine residues at positions 456 and 458. Histidine 88-97 toll like receptor 4 Homo sapiens 70-74 25886189-0 2015 Posttranslational modification and mutation of histidine 50 trigger alpha synuclein aggregation and toxicity. Histidine 47-56 synuclein alpha Homo sapiens 68-83 25060725-3 2015 The CMD-layer was found to be advantageous in terms of not only immobilization of histidine-tagged recombinant protein A-mediated an antibody against myoglobin (anti-Myo) but also prevention of non-specific binding of myoglobin. Histidine 82-91 myoglobin Homo sapiens 150-159 25060725-3 2015 The CMD-layer was found to be advantageous in terms of not only immobilization of histidine-tagged recombinant protein A-mediated an antibody against myoglobin (anti-Myo) but also prevention of non-specific binding of myoglobin. Histidine 82-91 myoglobin Homo sapiens 218-227 25608886-4 2015 In this study, we dissected the molecular mechanisms by which CCL2 neutralization inhibits HIV-1 replication in monocyte-derived macrophages (MDM), and the potential involvement of the innate restriction factors protein sterile alpha motif (SAM) histidine/aspartic acid (HD) domain containing 1 (SAMHD1) and apolipoprotein B mRNA-editing, enzyme-catalytic, polypeptide-like 3 (APOBEC3) family members. Histidine 246-255 C-C motif chemokine ligand 2 Homo sapiens 62-66 25421803-1 2014 BACKGROUND: The histidine ammonia-lyse gene (HAL) encodes the histidine ammonia-lyase, which catalyzes the first reaction of histidine catabolism. Histidine 16-25 histidine ammonia-lyase Bos taurus 45-48 25421803-1 2014 BACKGROUND: The histidine ammonia-lyse gene (HAL) encodes the histidine ammonia-lyase, which catalyzes the first reaction of histidine catabolism. Histidine 16-25 histidine ammonia-lyase Bos taurus 62-85 25295538-2 2014 Here, through transcriptional profiling of genetically labeled cardiomyocytes, we identified expression of Purkinje cell protein-4 (Pcp4), a putative regulator of calmodulin and Ca2+/calmodulin-dependent kinase II (CaMKII) signaling, exclusively within the His-Purkinje network. Histidine 257-260 Purkinje cell protein 4 Mus musculus 107-130 25295538-2 2014 Here, through transcriptional profiling of genetically labeled cardiomyocytes, we identified expression of Purkinje cell protein-4 (Pcp4), a putative regulator of calmodulin and Ca2+/calmodulin-dependent kinase II (CaMKII) signaling, exclusively within the His-Purkinje network. Histidine 257-260 Purkinje cell protein 4 Mus musculus 132-136 25049081-4 2014 Here, we constructed and characterized three catalytic triad mutants of TSP50 and found that all the mutants could significantly depress TSP50-induced cell proliferation and colony formation in vitro and tumor formation in vivo, and the aspartic acid at position 206 in the catalytic triad played a more crucial role than threonine and histidine in this process. Histidine 336-345 serine protease 50 Homo sapiens 72-77 25049081-4 2014 Here, we constructed and characterized three catalytic triad mutants of TSP50 and found that all the mutants could significantly depress TSP50-induced cell proliferation and colony formation in vitro and tumor formation in vivo, and the aspartic acid at position 206 in the catalytic triad played a more crucial role than threonine and histidine in this process. Histidine 336-345 serine protease 50 Homo sapiens 137-142 25229620-6 2014 In the present study, we expressed and purified recombinant human endostatin (rhEndostatin) that contained 3 additional amino acid residues (arginine, glycine, and serine) at the amino-terminus and 6 histidine residues in its carboxyl terminus. Histidine 200-209 collagen type XVIII alpha 1 chain Homo sapiens 66-76 25100325-0 2014 The C113D mutation in human Pin1 causes allosteric structural changes in the phosphate binding pocket of the PPIase domain through the tug of war in the dual-histidine motif. Histidine 158-167 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 Homo sapiens 28-32 24816719-7 2014 FAD2 proteins include highly conserved histidine-rich motifs (HECGHH, HRRHH and HV[A/C/T]HH) that are located by three to five transmembrane anchors. Histidine 39-48 omega-6 fatty acid desaturase, endoplasmic reticulum isozyme 2 Sesamum indicum 0-4 25027712-2 2014 Here we report structural results illuminating how LIMP-2 binds and releases beta-GCase according to changes in pH, via a histidine trigger, and suggesting that LIMP-2 localizes the ceramide portion of the substrate adjacent to the beta-GCase catalytic site. Histidine 122-131 scavenger receptor class B member 2 Homo sapiens 51-57 25027712-2 2014 Here we report structural results illuminating how LIMP-2 binds and releases beta-GCase according to changes in pH, via a histidine trigger, and suggesting that LIMP-2 localizes the ceramide portion of the substrate adjacent to the beta-GCase catalytic site. Histidine 122-131 glucosylceramidase beta Homo sapiens 77-87 24370479-6 2014 As for the C-terminal His-tagged rDlP5betaR the catalytic efficiency for progesterone was highest for the full-length rDlP5betaRc whereas the N-terminal truncated forms preferred 2-cyclohexen-1-one as the substrate. Histidine 22-25 dynein, axonemal, heavy chain 5 Rattus norvegicus 33-38 24626950-4 2014 The present study, showed that forced expression of an IDH1 mutant, of which the 132th amino acid residue arginine is substituted by histidine (IDH1R132H), promoted cell proliferation in cultured cells, while wild-type IDH1 overexpression had no effect on cell proliferation. Histidine 133-142 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 55-59 24626950-4 2014 The present study, showed that forced expression of an IDH1 mutant, of which the 132th amino acid residue arginine is substituted by histidine (IDH1R132H), promoted cell proliferation in cultured cells, while wild-type IDH1 overexpression had no effect on cell proliferation. Histidine 133-142 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 144-148 24733123-9 2014 Using specific beta-adrenoceptor antagonists, HIS-induced visceral hypersensitivity was alleviated by beta2 adrenoceptor antagonist but not by beta1- or beta3-adrenoceptor antagonist. Histidine 46-49 adrenoceptor beta 2 Rattus norvegicus 102-120 24509845-7 2014 We show that, contrary to the previously reported structures, Sgf73 ZnF adopts a C2H2 coordination with unusual tautomeric forms for the coordinating histidines. Histidine 150-160 deubiquitination module subunit SGF73 Saccharomyces cerevisiae S288C 62-67 24403080-2 2014 The C-terminal cytosolic domain of mitoNEET hosts a redox-active [2Fe-2S] cluster via an unusual ligand arrangement of three cysteine residues and one histidine residue. Histidine 151-160 CDGSH iron sulfur domain 1 Homo sapiens 35-43 24140707-2 2014 A single histidine residue in eEF2 (H715) is modified to form diphthamide. Histidine 9-18 eukaryotic translation elongation factor 2 Homo sapiens 30-34 24282278-7 2014 Recombinant MDA-7/IL-24 (His-MDA-7) induces SARI expression, supporting the involvement of SARI in the MDA-7/IL-24-driven autocrine loop, culminating in antitumor effects. Histidine 25-28 interleukin 24 Homo sapiens 12-17 24282278-7 2014 Recombinant MDA-7/IL-24 (His-MDA-7) induces SARI expression, supporting the involvement of SARI in the MDA-7/IL-24-driven autocrine loop, culminating in antitumor effects. Histidine 25-28 interleukin 24 Homo sapiens 18-23 24282278-7 2014 Recombinant MDA-7/IL-24 (His-MDA-7) induces SARI expression, supporting the involvement of SARI in the MDA-7/IL-24-driven autocrine loop, culminating in antitumor effects. Histidine 25-28 interleukin 24 Homo sapiens 29-34 24282278-7 2014 Recombinant MDA-7/IL-24 (His-MDA-7) induces SARI expression, supporting the involvement of SARI in the MDA-7/IL-24-driven autocrine loop, culminating in antitumor effects. Histidine 25-28 interleukin 24 Homo sapiens 29-34 24282278-7 2014 Recombinant MDA-7/IL-24 (His-MDA-7) induces SARI expression, supporting the involvement of SARI in the MDA-7/IL-24-driven autocrine loop, culminating in antitumor effects. Histidine 25-28 interleukin 24 Homo sapiens 109-114 24282278-8 2014 Moreover, His-MDA-7, after binding to its cognate receptors (IL-20R1/IL-20R2 or IL-22R/IL-20R2), induces intracellular signaling by phosphorylation of p38 MAPK, leading to transcription of a family of growth arrest and DNA damage inducible (GADD) genes, culminating in apoptosis. Histidine 10-13 interleukin 24 Homo sapiens 14-19 24449363-4 2014 We detected an association between HNC and CYP1A1 6310C>T (TT) and CYP2D6 Arg365His (His/His) variant carriers (OR 1.75, P = 0.008 and OR 1.66, P = 0.016, respectively). Histidine 83-86 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 43-49 24449363-4 2014 We detected an association between HNC and CYP1A1 6310C>T (TT) and CYP2D6 Arg365His (His/His) variant carriers (OR 1.75, P = 0.008 and OR 1.66, P = 0.016, respectively). Histidine 88-91 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 43-49 24000822-5 2014 The inhibitor was stabilized by hydrogen bonding interactions with residues Arg 145, Asn 566, Pro 731 and His 732 of hECE-1. Histidine 106-109 endothelin converting enzyme 1 Homo sapiens 117-123 24056075-2 2013 To establish an ultrasensitive receptor-binding assay for INSL3-RXFP2 interaction studies, in the present work we labeled a recombinant INSL3 peptide with a newly developed nanoluciferase (NanoLuc) reporter through a convenient chemical conjugation approach, including the introduction of an active disulfide bond to INSL3 by chemical modification and engineering of a 6x His-Cys-NanoLuc carrying a unique exposed cysteine at the N-terminus. Histidine 372-375 insulin like 3 Homo sapiens 136-141 24056075-2 2013 To establish an ultrasensitive receptor-binding assay for INSL3-RXFP2 interaction studies, in the present work we labeled a recombinant INSL3 peptide with a newly developed nanoluciferase (NanoLuc) reporter through a convenient chemical conjugation approach, including the introduction of an active disulfide bond to INSL3 by chemical modification and engineering of a 6x His-Cys-NanoLuc carrying a unique exposed cysteine at the N-terminus. Histidine 372-375 insulin like 3 Homo sapiens 136-141 24100012-3 2013 Combining the yeast two-hybrid system with genetic analysis, we show here that the cysteine- and histidine-rich (CH) domain and the RNA helicase domain of yeast Upf1 can engage in two new types of molecular interactions: an intramolecular interaction between these two domains and self-association of each of these domains. Histidine 97-106 ATP-dependent RNA helicase NAM7 Saccharomyces cerevisiae S288C 161-165 23971743-1 2013 Eukaryotic and archaeal elongation factor 2 contains a unique post-translationally modified histidine residue, named diphthamide. Histidine 92-101 eukaryotic translation elongation factor 2 Homo sapiens 24-43 24224020-7 2013 ZNF24 containing histidine to leucine mutations that disrupt the structure of ZF1 or/and ZF2 retains appropriate nuclear localization, indicating that neither the tertiary structure of the zinc fingers nor specific DNA binding are necessary for nuclear localization. Histidine 17-26 zinc finger protein 24 Homo sapiens 0-5 24082096-4 2013 Functional studies on channel mutants and structural investigations on recombinant inactivation ball domain peptides encompassing the first 61 residues of Kv1.4 revealed a heme-responsive binding motif involving Cys13:His16 and a secondary histidine at position 35. Histidine 240-249 potassium voltage-gated channel subfamily A member 4 Homo sapiens 155-160 24098330-4 2013 The purified His-tag fusion proteins of W69 and W106 reduced H2O2 and t-butyl hydroperoxide (t-BHP) using glutathione (GSH) or thioredoxin (Trx) as an electron donor in vitro, showing their peroxidase activity toward H2O2 and toxic organic hydroperoxide. Histidine 13-16 thioredoxin Homo sapiens 127-138 24098330-4 2013 The purified His-tag fusion proteins of W69 and W106 reduced H2O2 and t-butyl hydroperoxide (t-BHP) using glutathione (GSH) or thioredoxin (Trx) as an electron donor in vitro, showing their peroxidase activity toward H2O2 and toxic organic hydroperoxide. Histidine 13-16 thioredoxin Homo sapiens 140-143 24037091-2 2013 Here, we show that after acute myocardial infarction in mice, mature B lymphocytes selectively produce Ccl7 and induce Ly6C(hi) monocyte mobilization and recruitment to the heart, leading to enhanced tissue injury and deterioration of myocardial function. Histidine 124-126 lymphocyte antigen 6 complex, locus C1 Mus musculus 119-123 24137022-8 2013 Also the pathophysiological relevance of serum carnosinase, the enzyme actively degrading carnosine into l-histidine and beta-alanine, is discussed. Histidine 105-116 carnosine dipeptidase 1 Homo sapiens 41-58 24001608-6 2013 Analyses of oastlABC pollen demonstrated that the presence of at least one functional OAS-TL isoform is essential for the proper function of the male gametophyte, although the synthesis of histidine, lysine, and tryptophan is dispensable in pollen. Histidine 189-198 O-acetylserine (thiol) lyase (OAS-TL) Arabidopsis thaliana 86-92 23873822-8 2013 Amino acid residues of histidine at position 171 and phenylalanine at position 67, both of which are located in antigen binding grooves of the HLA-B protein, were associated with TAK susceptibility (P <= 3.8 x 10(-5)) with a significant difference from other amino acid variations (DeltaAIC >= 9.65). Histidine 23-32 major histocompatibility complex, class I, B Homo sapiens 143-148 24043698-6 2013 http://dx.doi.org/10.1083/jcb.201308034) show that pHi increase activates FAK by causing deprotonation of histidine 58 in its FERM (band 4.1, ezrin, radixin, moesin) homology domain, which exposes a region important for FAK autophosphorylation. Histidine 106-115 ezrin Homo sapiens 142-148 23818523-8 2013 However, PEDF-R polypeptides without the His(203)-Leu(232) region lost the PEDF affinity that stimulated their enzymatic activity. Histidine 41-44 patatin like phospholipase domain containing 2 Homo sapiens 9-15 23718776-6 2013 Remarkably, His382 is mainly conserved across other members of the EGR family, implying that histidine protonation-deprotonation may serve as a molecular switch for modulating the protein-DNA interactions that are central to this family of transcription factors. Histidine 93-102 early growth response 1 Homo sapiens 67-70 23541716-8 2013 Additionally, three novel PTMs in ITIH3 were identified and include hexose-N-acetyl-hexosamine at asparagine-(41), trimethylation at aspartic acid-(290), and flavin adenine dinucleotide at histidine-(335). Histidine 189-198 inter-alpha-trypsin inhibitor heavy chain 3 Homo sapiens 34-39 23678519-20 2004 A cyclic heptapeptide, cyclo(Cys-Asn-Asn-Ser-Lys-Ser-His-Thr-Cys) (R832), was identified with phage screening against VCAM-1 (12). Histidine 53-56 vascular cell adhesion molecule 1 Mus musculus 118-124 22867050-5 2013 RESULTS: Incubation with HNE promoted the oligomerization of recombinant human alpha-synuclein via adduct formation at the lysine and histidine residues. Histidine 134-143 synuclein alpha Homo sapiens 79-94 23297402-1 2013 Since the elucidation of the myoglobin (Mb) structure, a histidine residue on the E helix (His-E7) has been proposed to act as a gate with an open or closed conformation controlling access to the active site. Histidine 57-66 myoglobin Homo sapiens 29-38 23297402-1 2013 Since the elucidation of the myoglobin (Mb) structure, a histidine residue on the E helix (His-E7) has been proposed to act as a gate with an open or closed conformation controlling access to the active site. Histidine 57-66 myoglobin Homo sapiens 40-42 23297402-1 2013 Since the elucidation of the myoglobin (Mb) structure, a histidine residue on the E helix (His-E7) has been proposed to act as a gate with an open or closed conformation controlling access to the active site. Histidine 91-94 myoglobin Homo sapiens 29-38 23297402-1 2013 Since the elucidation of the myoglobin (Mb) structure, a histidine residue on the E helix (His-E7) has been proposed to act as a gate with an open or closed conformation controlling access to the active site. Histidine 91-94 myoglobin Homo sapiens 40-42 23297402-2 2013 Although it is believed that at low pH, the His-E7 gate is in its open conformation, the full relationship between the His-E7 protonation state, its conformation, and ligand migration in Mb is hotly debated. Histidine 44-47 myoglobin Homo sapiens 187-189 23297402-2 2013 Although it is believed that at low pH, the His-E7 gate is in its open conformation, the full relationship between the His-E7 protonation state, its conformation, and ligand migration in Mb is hotly debated. Histidine 119-122 myoglobin Homo sapiens 187-189 23283979-7 2013 These data suggest that Cys-373 and His-880 in Na(V)1.5 are proton sensors for use-dependent and slow inactivation and have implications in isoform-specific modulation of Na(V) channels. Histidine 36-39 immunoglobulin lambda variable 2-18 Homo sapiens 47-55 23154171-5 2013 NMR pH titration of histidine residues of beta2m has also indicated that His84 has an abnormally low pK(a) value in the native state. Histidine 20-29 beta-2-microglobulin Homo sapiens 42-48 23685414-2 2013 Since this mutation is expected to change amino acid coding from histidine to tyrosine and cause an altered insulin receptor substrate-4 protein, and the insulin receptor substrate-4 protein may be involved in neuronal growth and function in the brain, it is possible that it is this insulin receptor substrate-4 gene mutation that underlies this patient"s schizophrenia development. Histidine 65-74 insulin receptor substrate 4 Homo sapiens 108-136 22974464-5 2013 Our data indicate that the cysteine-histidine-rich (CH) and helicase domains of UPF1 are only essential for the early steps of NMD, whereas the heavily phosphorylated N- and C-terminal regions play a redundant but essential role in the target transcript degradation steps of NMD. Histidine 36-45 UPF1 RNA helicase and ATPase Homo sapiens 80-84 23153210-10 2012 Notably, two NPC1 haplotypes were also associated with T2D in men (rs1805081-rs1788799, His-Met: P = 0.0012, OR = 1.54; His-Ile: P = 0.0004, OR = 0.63). Histidine 88-91 NPC intracellular cholesterol transporter 1 Homo sapiens 13-17 23153210-10 2012 Notably, two NPC1 haplotypes were also associated with T2D in men (rs1805081-rs1788799, His-Met: P = 0.0012, OR = 1.54; His-Ile: P = 0.0004, OR = 0.63). Histidine 120-123 NPC intracellular cholesterol transporter 1 Homo sapiens 13-17 22490985-6 2012 Sequence analysis of the coding region of the SCN5A gene, identified a G to A heterozygous missense mutation at nucleotide site 2066 that resulted in a amino-acid substitution of arginine to histidine at amino-acid site 689 (R689H). Histidine 191-200 sodium voltage-gated channel alpha subunit 5 Homo sapiens 46-51 22560897-7 2012 AtMRS2-10, which contains an N-terminal His-tag, was expressed in Escherichia coli and solubilized with sarcosyl. Histidine 40-43 magnesium transporter 1 Arabidopsis thaliana 0-9 22187146-5 2012 First, the N-terminal 6 x His-tag of the single-chain relaxin-3 precursor was removed by Aeromonas aminopeptidase and all of the primary amines of the resultant peptide were reversibly blocked by citroconic anhydride. Histidine 26-29 relaxin 3 Homo sapiens 54-63 22863590-5 2012 RESULTS: Recombinant His-AKR7A5 was successfully purified as confirmed by SDS-PAGE and Western blotting. Histidine 21-24 aldo-keto reductase family 7, member A5 (aflatoxin aldehyde reductase) Mus musculus 25-31 22240897-3 2012 Here, we repot that golgi-specific Asp-His-His-Cys (DHHC) zinc finger protein (GODZ) regulates TRAIL/DR4-mediated apoptosis. Histidine 39-42 zinc finger DHHC-type palmitoyltransferase 3 Homo sapiens 79-83 22773562-4 2012 Chloramines of taurine and histidine caused slight damage to PCNA in cells. Histidine 27-36 proliferating cell nuclear antigen Homo sapiens 61-65 22552365-4 2012 Our results demonstrated that the cells expressing the hCTR1 mutants of histidine-rich motifs in the N-terminus (H22-24A, NHA) resulted in a higher basal copper level in the steady state compared to those expressing wild-type protein. Histidine 72-81 solute carrier family 31 member 1 Homo sapiens 55-60 22556417-6 2012 Simultaneous mutation of these three histidines to alanines decreased the zinc potency of hP2X2 nearly 100-fold. Histidine 37-47 purinergic receptor P2X 2 Homo sapiens 90-95 22415292-3 2012 In the presence of Cu(2+), remarkable myoglobin binding to the binary monolayers resulted from the formation of ternary complexes of iminodiacetate (IDA)-Cu(2+)-surface histidine. Histidine 169-178 myoglobin Homo sapiens 38-47 22181833-4 2012 We found that not only lysine but also arginine and histidine bound well, and when present with an additional proximal positive charge, accounted for about half of the total binding energy of a protein ligand such as PAI-1 (plasminogen activator inhibitor-1). Histidine 52-61 serpin family E member 1 Homo sapiens 217-222 22181833-4 2012 We found that not only lysine but also arginine and histidine bound well, and when present with an additional proximal positive charge, accounted for about half of the total binding energy of a protein ligand such as PAI-1 (plasminogen activator inhibitor-1). Histidine 52-61 serpin family E member 1 Homo sapiens 224-257 26593369-5 2012 Since the EPR results seemingly cannot be used to unequivocally assign the protonation states, the pKa values of the two histidines were calculated using the popular PROPKA, H++, and APBS approaches, in various environments and for several lesions. Histidine 121-131 Protein kinase, cAMP-dependent, catalytic subunit 2 Drosophila melanogaster 99-102 22590679-5 2012 However, when dialyzed together with Gst-gp3 or with Gst-gp4, His-gp2b and His-gp4 remain soluble and oligomers are obtained by affinity-chromatography. Histidine 75-78 CD36 molecule Homo sapiens 57-60 22590679-5 2012 However, when dialyzed together with Gst-gp3 or with Gst-gp4, His-gp2b and His-gp4 remain soluble and oligomers are obtained by affinity-chromatography. Histidine 75-78 CD36 molecule Homo sapiens 79-82 22236003-8 2012 Our results show that glycine, histidine and cysteine can inhibit NF-kappaB activation, IkappaBalpha degradation, CD62E expression and IL-6 production in HCAECs, suggesting that these amino acids may exhibit anti-inflammatory effects during endothelial inflammation. Histidine 31-40 selectin E Homo sapiens 114-119 22139846-6 2012 Expression of HvMTP1/AtMTP1 chimeras in yeast revealed a five-residue sequence within the AtMTP1 N-segment of the His-rich intracytoplasmic loop that confines specificity to Zn(2+). Histidine 114-117 zinc transporter Arabidopsis thaliana 21-27 22139846-6 2012 Expression of HvMTP1/AtMTP1 chimeras in yeast revealed a five-residue sequence within the AtMTP1 N-segment of the His-rich intracytoplasmic loop that confines specificity to Zn(2+). Histidine 114-117 zinc transporter Arabidopsis thaliana 90-96 22553750-4 2012 RESULTS: Mutational analysis of mtDNA in these two Chinese pedigrees revealed one common LHON-associated mutation, G11778A (Arg His), in the MT-ND4 gene. Histidine 128-131 mitochondrially encoded NADH dehydrogenase 4 Homo sapiens 141-147 22056627-3 2012 The substitution of arginine to histidine (R279H), due to a c.836G>A mutation in exon 7 of the p63 gene, represents 55% of the identified mutations and is considered a mutational hot spot. Histidine 32-41 tumor protein p63 Homo sapiens 98-101 21719207-0 2012 Heat-induced gelation of myosin in a low ionic strength solution containing L-histidine. Histidine 76-87 myosin heavy chain 14 Homo sapiens 25-31 21719207-2 2012 We have shown that myosin is solubilized in a low ionic strength solution containing L-histidine. Histidine 85-96 myosin heavy chain 14 Homo sapiens 19-25 21719207-4 2012 Myosin in a low ionic strength solution formed transparent gels at 40-50 C, while myosin in a high ionic strength solution formed opaque gels at 60-70 C. The gel of myosin in a low ionic strength solution with L-histidine showed a fine network consisting of thin strands and its viscosity was lower than that of myosin in a high ionic strength solution at 40-50 C. The rheological properties of heat-induced gels of myosin at low ionic strength are different from those at high ionic strength. Histidine 210-221 myosin heavy chain 14 Homo sapiens 82-88 21719207-4 2012 Myosin in a low ionic strength solution formed transparent gels at 40-50 C, while myosin in a high ionic strength solution formed opaque gels at 60-70 C. The gel of myosin in a low ionic strength solution with L-histidine showed a fine network consisting of thin strands and its viscosity was lower than that of myosin in a high ionic strength solution at 40-50 C. The rheological properties of heat-induced gels of myosin at low ionic strength are different from those at high ionic strength. Histidine 210-221 myosin heavy chain 14 Homo sapiens 165-171 21719207-4 2012 Myosin in a low ionic strength solution formed transparent gels at 40-50 C, while myosin in a high ionic strength solution formed opaque gels at 60-70 C. The gel of myosin in a low ionic strength solution with L-histidine showed a fine network consisting of thin strands and its viscosity was lower than that of myosin in a high ionic strength solution at 40-50 C. The rheological properties of heat-induced gels of myosin at low ionic strength are different from those at high ionic strength. Histidine 210-221 myosin heavy chain 14 Homo sapiens 165-171 21719207-4 2012 Myosin in a low ionic strength solution formed transparent gels at 40-50 C, while myosin in a high ionic strength solution formed opaque gels at 60-70 C. The gel of myosin in a low ionic strength solution with L-histidine showed a fine network consisting of thin strands and its viscosity was lower than that of myosin in a high ionic strength solution at 40-50 C. The rheological properties of heat-induced gels of myosin at low ionic strength are different from those at high ionic strength. Histidine 210-221 myosin heavy chain 14 Homo sapiens 165-171 21719207-5 2012 This difference might be caused by structural changes in the rod region of myosin in a low ionic strength solution containing L-histidine. Histidine 126-137 myosin heavy chain 14 Homo sapiens 75-81 22118311-8 2011 RESULTS: Subjects with EPHX1 113 (His(113)/His(113)) homozygote mutation had a strong correlation with COPD (odds ratio: 2.7, 95% confidence interval: 1.5-5.2). Histidine 34-37 epoxide hydrolase 1 Homo sapiens 23-28 22118311-8 2011 RESULTS: Subjects with EPHX1 113 (His(113)/His(113)) homozygote mutation had a strong correlation with COPD (odds ratio: 2.7, 95% confidence interval: 1.5-5.2). Histidine 43-46 epoxide hydrolase 1 Homo sapiens 23-28 21849510-5 2011 C-terminal topology reporters added to truncated versions of Gup1p yield a topology predicting a lumenal location of its uniquely conserved histidine 447 residue. Histidine 140-149 O-acyltransferase Saccharomyces cerevisiae S288C 61-66 21849510-6 2011 The same approach shows that Ale1p and Are2p also have the uniquely conserved histidine residing in the ER lumen. Histidine 78-87 sterol acyltransferase Saccharomyces cerevisiae S288C 39-44 23888104-2 2011 These studies were conducted to determine hPHT1-mediated, H+-dependent uptake kinetics of histidine, carnosine, Gly-Sar and valacyclovir in stably transfected hPHT1-COS-7 cells comparative to kinetics determined in an empty vector (Mock) stably transfected cell line. Histidine 90-99 solute carrier family 15 member 4 Homo sapiens 42-47 21757694-2 2011 Carboxyl-terminally His-FLAG-tagged human P2X1 receptors were stably expressed in HEK293 cells and co-purified with cytoskeletal proteins including actin. Histidine 20-23 purinergic receptor P2X 1 Homo sapiens 42-46 21882401-0 2004 3-Cyano-4-[(18)F]fluoro-benzoyl-Ala(SO3H)-Ala(SO3H)-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2 The amphibian bombesin (BBN or BN, a peptide of 14 amino acids) is an analog of human gastrin-releasing peptide (GRP, a peptide of 27 amino acids), which binds to the GRP receptor (GRPR) with high affinity and specificity (1). Histidine 79-82 GCY Homo sapiens 83-86 21680741-7 2011 These data indicated that His-396 is important for the formation of the C4a-hydroperoxy-FMN intermediate but is not involved in H(2)O(2) elimination. Histidine 26-29 formin 1 Homo sapiens 88-91 21680741-11 2011 The double mutant S171A/H396V reacted with oxygen to directly form the oxidized flavin without stabilizing the C4a-hydroperoxy-FMN intermediate, which confirmed the findings based on the single mutation that His-396 was important for formation and Ser-171 for stabilization of the C4a-hydroperoxy-FMN intermediate in C(2). Histidine 208-211 complement C4A (Rodgers blood group) Homo sapiens 281-284 21680741-11 2011 The double mutant S171A/H396V reacted with oxygen to directly form the oxidized flavin without stabilizing the C4a-hydroperoxy-FMN intermediate, which confirmed the findings based on the single mutation that His-396 was important for formation and Ser-171 for stabilization of the C4a-hydroperoxy-FMN intermediate in C(2). Histidine 208-211 formin 1 Homo sapiens 297-300 21543521-7 2011 The results suggest that HCC1 is the protein involved in COX biogenesis and that HCC2, that lacks the cysteines and histidine putatively involved in copper binding, functions in copper sensing and redox homeostasis. Histidine 116-125 Thioredoxin superfamily protein Arabidopsis thaliana 81-85 21811984-5 2011 RESULTS: A heterozygous 467G>A mutation was found in the patient, resulting in the substitution of arginine (R) by histidine (H) in codon 156 (R156H) in the 1A domain of the KRT10 protein but not in the healthy individuals from the family and the 50 unrelated individuals. Histidine 118-127 keratin 10 Homo sapiens 177-182 21549153-5 2011 There was a significant difference in HI antibody levels (P<0.05) elicited by either rFPV-HA or rFPV-HA/IL18. Histidine 38-40 interleukin 18 Gallus gallus 107-111 21488608-3 2011 This detection is based on the Mb-induced aggregation of IDA-functionalized AuNPs resulting from the structures of Mb sandwiched between the functionalized AuNPs via Cu(2+) bridges in the coordination interactions of IDA-Cu(2+)-histidine residues available on the Mb surface, which was confirmed by UV-vis spectroscopy, transmission electron microscopy, dynamic light scattering, and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Histidine 228-237 myoglobin Homo sapiens 31-33 21488608-3 2011 This detection is based on the Mb-induced aggregation of IDA-functionalized AuNPs resulting from the structures of Mb sandwiched between the functionalized AuNPs via Cu(2+) bridges in the coordination interactions of IDA-Cu(2+)-histidine residues available on the Mb surface, which was confirmed by UV-vis spectroscopy, transmission electron microscopy, dynamic light scattering, and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Histidine 228-237 myoglobin Homo sapiens 115-117 21488608-3 2011 This detection is based on the Mb-induced aggregation of IDA-functionalized AuNPs resulting from the structures of Mb sandwiched between the functionalized AuNPs via Cu(2+) bridges in the coordination interactions of IDA-Cu(2+)-histidine residues available on the Mb surface, which was confirmed by UV-vis spectroscopy, transmission electron microscopy, dynamic light scattering, and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Histidine 228-237 myoglobin Homo sapiens 115-117 21449573-3 2011 It has been confirmed that FXYD1 spontaneously associates in vitro with the alpha(1)/His(10)-beta(1) complex and stabilizes it in an active mode. Histidine 85-88 adrenoceptor alpha 1D Homo sapiens 76-84 21449573-4 2011 The functional properties of the alpha(1)/His(10)-beta(1) and alpha(1)/His(10)-beta(1)/FXYD1 complexes have been investigated by fluorescence methods. Histidine 42-45 adrenoceptor alpha 1D Homo sapiens 33-41 21449573-4 2011 The functional properties of the alpha(1)/His(10)-beta(1) and alpha(1)/His(10)-beta(1)/FXYD1 complexes have been investigated by fluorescence methods. Histidine 71-74 adrenoceptor alpha 1D Homo sapiens 62-70 21377473-8 2011 We propose a model of the tetrahedral coordination of a Zn(2+) by (Cys)(3)His residues that is compatible with SS2 formation in S100A3. Histidine 74-77 S100 calcium binding protein A3 Homo sapiens 128-134 21490302-8 2011 Resequencing analysis pinpointed the association to a histidine (basic amino acid) for aspartic acid (acidic amino acid) substitution in the encoded protein domain that defines GST substrate specificity and biochemical activity. Histidine 54-63 glutathione S-transferase Zea mays 177-180 21563331-0 2004 (68)Ga-DOTA-4-amino-1-carboxymethyl-piperidine-D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2 The amphibian bombesin (BBN or BN, a peptide of 14 amino acids) is an analog of human gastrin-releasing peptide (GRP, a peptide of 27 amino acids) that binds to GRP receptor (GRPR) with high affinity and specificity (1). Histidine 73-76 GCY Homo sapiens 77-80 21563331-12 2004 A DOTA-Gly-benzoyl group was added to the C-terminus to form DOTA-Gly-benzoyl-d-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2 (RM1). Histidine 104-107 GCY Homo sapiens 108-111 21531294-14 2011 In the untreated group, intense uptake of His(10)-annexin V was visualized in the defect which was shown in MPI, whereas in the adenosine group a mild uptake of (99m)Tc-His(10)-annexin was found in the risk area which showed no defects in the (99m)Tc-MIBI image. Histidine 42-45 annexin A5 Homo sapiens 50-59 21531294-17 2011 Uptake of His(10)-annexin V in RI correlated with TUNEL-positive nuclei. Histidine 10-13 annexin A5 Homo sapiens 18-27 21183608-6 2011 RESULTS: Children with the EPHX1 Arg/His or Arg/Arg genotypes at codon 139 were significantly associated with increased risks of lifetime asthma (adjusted OR [aOR] = 1.3; 95% CI, 1.1-1.7; and aOR = 1.5; 95% CI, 1.1-2.1, respectively). Histidine 37-40 epoxide hydrolase 1 Homo sapiens 27-32 21279630-3 2011 Among these, it was found that insertion of oxygen atoms occurred at histidine for HG and HGG, and both histidine and glycine for GH, GHG, and GGH. Histidine 104-113 gamma-glutamyl hydrolase Homo sapiens 143-146 20641535-0 2004 (111)In-DOTA-Gly-benzoyl-D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2 The amphibian bombesin (BBN or BN, a peptide of 14 amino acids) is an analog of human gastrin-releasing peptide (GRP, a peptide of 27 amino acids) that binds to GRP receptors (GRPR) with high affinity and specificity (1). Histidine 51-54 GCY Homo sapiens 55-58 20641535-12 2004 DOTA-Gly-benzoyl group was added to the C-terminus to form DOTA-Gly-benzoyl-D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2 (RM1). Histidine 102-105 GCY Homo sapiens 106-109 21290627-0 2004 3-Cyano-4-[(18)F]fluoro-benzoyl-Ala(SO3H)-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2 3-Cyano-4-[(18)F]fluoro-benzoyl-Ala(SO3H)-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2, abbreviated as [(18)F]7b, is a bombesin (BN)-based (18)F-labeled peptide synthesized by Mu et al. Histidine 154-157 GCY Homo sapiens 73-76 21290627-0 2004 3-Cyano-4-[(18)F]fluoro-benzoyl-Ala(SO3H)-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2 3-Cyano-4-[(18)F]fluoro-benzoyl-Ala(SO3H)-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2, abbreviated as [(18)F]7b, is a bombesin (BN)-based (18)F-labeled peptide synthesized by Mu et al. Histidine 154-157 GCY Homo sapiens 158-161 20962270-0 2011 Structure-function activity of the human sodium-dependent multivitamin transporter: role of His&#185;&#185;&#8309; and His254. Histidine 92-95 solute carrier family 5 member 6 Homo sapiens 41-82 20962270-4 2011 Using site-directed mutagenesis approach, we examined the role of the positively charged histidine (His) residues of the human SMVT (hSMVT) in transporting the negatively charged biotin. Histidine 89-98 solute carrier family 5 member 6 Homo sapiens 127-131 20962270-4 2011 Using site-directed mutagenesis approach, we examined the role of the positively charged histidine (His) residues of the human SMVT (hSMVT) in transporting the negatively charged biotin. Histidine 89-98 solute carrier family 5 member 6 Homo sapiens 133-138 20962270-4 2011 Using site-directed mutagenesis approach, we examined the role of the positively charged histidine (His) residues of the human SMVT (hSMVT) in transporting the negatively charged biotin. Histidine 100-103 solute carrier family 5 member 6 Homo sapiens 127-131 20962270-4 2011 Using site-directed mutagenesis approach, we examined the role of the positively charged histidine (His) residues of the human SMVT (hSMVT) in transporting the negatively charged biotin. Histidine 100-103 solute carrier family 5 member 6 Homo sapiens 133-138 20962270-5 2011 Of the seven conserved (across species) His residues in the hSMVT polypeptide, only His115 and His254 were found to be important for the function of hSMVT as their mutation led to a significant reduction in carrier-mediated biotin uptake. Histidine 40-43 solute carrier family 5 member 6 Homo sapiens 60-65 20962270-5 2011 Of the seven conserved (across species) His residues in the hSMVT polypeptide, only His115 and His254 were found to be important for the function of hSMVT as their mutation led to a significant reduction in carrier-mediated biotin uptake. Histidine 40-43 solute carrier family 5 member 6 Homo sapiens 149-154 21966400-0 2011 Fibrillization of human tau is accelerated by exposure to lead via interaction with His-330 and His-362. Histidine 84-87 microtubule associated protein tau Homo sapiens 24-27 21208569-2 2011 METHODS: The recombinant expression plasmid pET32a-His-PCGF1-128/189 was made and transformed into E.coli (BL21), and then the recombinant fusion protein His-PCGF1-128/189 was expressed and purified. Histidine 51-54 polycomb group ring finger 1 Homo sapiens 55-60 21208569-2 2011 METHODS: The recombinant expression plasmid pET32a-His-PCGF1-128/189 was made and transformed into E.coli (BL21), and then the recombinant fusion protein His-PCGF1-128/189 was expressed and purified. Histidine 51-54 polycomb group ring finger 1 Homo sapiens 158-163 21208569-2 2011 METHODS: The recombinant expression plasmid pET32a-His-PCGF1-128/189 was made and transformed into E.coli (BL21), and then the recombinant fusion protein His-PCGF1-128/189 was expressed and purified. Histidine 154-157 polycomb group ring finger 1 Homo sapiens 55-60 21208569-8 2011 RESULTS: The recombinant protein His-PCGF1-128/189 was expressed and purified. Histidine 33-36 polycomb group ring finger 1 Homo sapiens 37-42 20884616-3 2010 We previously showed that NDPK-B activates the K(+) channel KCa3.1 via histidine phosphorylation of the C terminus of KCa3.1, which is required for T cell receptor-stimulated Ca(2+) flux and proliferation of activated naive human CD4 T cells. Histidine 71-80 NME/NM23 nucleoside diphosphate kinase 2 Homo sapiens 26-32 20828147-8 2010 For this purpose, we produced and purified His-WT alpha-syn, a recombinant alpha-syn with a polyhistidine tag (six His residues) and a linker, and a number of Pro-to-Ala mutants. Histidine 43-46 synuclein alpha Homo sapiens 50-59 20818390-3 2010 Like the bacterial enzyme, Mesh1 proteins contain an active site for ppGpp hydrolysis and a conserved His-Asp-box motif for Mn(2+) binding. Histidine 102-105 Metazoan SpoT homolog-1 Drosophila melanogaster 27-32 20567816-4 2010 Immunoblotting using anti-6x His and anti-FLAG antibodies revealed that, in addition to full-length protein, Dga1p lacking the N-terminus was produced only in the Deltasnf2 disruptant. Histidine 29-32 diacylglycerol O-acyltransferase Saccharomyces cerevisiae S288C 109-114 20711192-5 2010 Studies with mutant TLR4 proteins revealed that the non-conserved histidines 456 and 458 of human TLR4 are required for activation by Ni(2+) but not by the natural ligand lipopolysaccharide. Histidine 66-76 toll like receptor 4 Homo sapiens 20-24 20711192-5 2010 Studies with mutant TLR4 proteins revealed that the non-conserved histidines 456 and 458 of human TLR4 are required for activation by Ni(2+) but not by the natural ligand lipopolysaccharide. Histidine 66-76 toll like receptor 4 Homo sapiens 98-102 20599753-12 2010 The active site of the catalytic domain of GBBH is similar to that of other 2KG oxygenases, and Fe(II)-binding residues form a conserved His-X-Asp-X(n)-His triad, which is found in all related enzymes. Histidine 152-155 gamma-butyrobetaine hydroxylase 1 Homo sapiens 43-47 20599753-12 2010 The active site of the catalytic domain of GBBH is similar to that of other 2KG oxygenases, and Fe(II)-binding residues form a conserved His-X-Asp-X(n)-His triad, which is found in all related enzymes. Histidine 137-140 gamma-butyrobetaine hydroxylase 1 Homo sapiens 43-47 20388494-2 2010 A pair of mutation-sensitive and highly conserved histidines in the sixth transmembrane domain (TM6) of DMT1 was found to be important for proton-metal ion cotransport. Histidine 50-60 solute carrier family 11 member 2 Homo sapiens 104-108 20388494-13 2010 The specific "alpha-helix-extended segment-alpha-helix" structure of TM6 may have an important implication for the binding of the transporter to H(+) and metal ions and the conformation change induced by the mutations of two highly conserved histidines may be correlated to the deficiency of the transport activity of DMT1. Histidine 242-252 solute carrier family 11 member 2 Homo sapiens 318-322 20715989-2 2010 USP17 has highly conserved Cys, His, and Asp domains responsible for the deubiquitinating activity, and two hyaluronan binding motifs in its sequence. Histidine 32-35 ubiquitin specific peptidase 17 like family member 9, pseudogene Homo sapiens 0-5 20382256-0 2010 The conserved histidine in epidermal growth factor-like domains of stabilin-2 modulates pH-dependent recognition of phosphatidylserine in apoptotic cells. Histidine 14-23 stabilin 2 Homo sapiens 67-77 20382256-6 2010 The PS binding activity of stabilin-2 is enhanced in low pH, and a conserved histidine(1403) in close proximity to the PS binding loop is critical for pH-dependent activity. Histidine 77-86 stabilin 2 Homo sapiens 27-37 20382256-7 2010 We propose that protonation of His(1403) may rearrange the PS binding loop to enhance binding affinity in low pH, indicating that acidic pH might act as a danger signal to stimulate stabilin-2-mediated phagocytosis to resolve inflammation. Histidine 31-34 stabilin 2 Homo sapiens 182-192 20347988-4 2010 A new protocol has been developed for expression and purification of S. cerevisiae Hop1 protein, based on the presence of hexa-histidine tag and double-stranded DNA-Cellulose chromatography. Histidine 127-136 Hop1p Saccharomyces cerevisiae S288C 83-87 20598110-2 2010 Comparison of the substrate-binding site of PRCP with that of its family partner, dipeptidyl dipeptidase 7 (DPP7), helps to explain the different enzymatic activities of these structurally similar proteins, and also reveals a novel apparent charge-relay system in PRCP involving the active-site catalytic histidine. Histidine 305-314 dipeptidyl peptidase 7 Homo sapiens 93-106 20598110-2 2010 Comparison of the substrate-binding site of PRCP with that of its family partner, dipeptidyl dipeptidase 7 (DPP7), helps to explain the different enzymatic activities of these structurally similar proteins, and also reveals a novel apparent charge-relay system in PRCP involving the active-site catalytic histidine. Histidine 305-314 dipeptidyl peptidase 7 Homo sapiens 108-112 20534569-6 2010 Comparison with previously reported data for denatured state His-heme loop formation for iso-1-cytochrome c and Rhodopseudomonas palustris cytochrome c", shows that foldable sequences deviate significantly from random coil behavior and that the deviation is fold-dependent. Histidine 61-64 threonine ammonia-lyase ILV1 Saccharomyces cerevisiae S288C 89-94 20304780-5 2010 The activated DJ-1 functions as a cysteine protease with Cys-106 and His-126 as the catalytic diad. Histidine 69-72 Parkinsonism associated deglycase Homo sapiens 14-18 20130963-5 2010 After purification with Ni-NTA His-Bind resin, the yield of recombinant lactoferrin was 17 mg l(-1) with purity of 92.1%, and that of lactoferrin N-lobe was 20 mg l(-1) with purity of 98.5%. Histidine 31-34 lactotransferrin Mus musculus 72-83 20194481-8 2010 The rs540825 polymorphism is a nonsynonymous SNP in the final exon of the mu-opioid receptor-1X isoform of the OPRM1 gene, resulting in a histidine to glutamine change in the intracellular domain of the receptor. Histidine 138-147 opioid receptor mu 1 Homo sapiens 111-116 20044482-3 2010 Hexahistidine-tagged rat TRPV4 (His-rTRPV4) was solubilized with detergent and purified through affinity chromatography and size-exclusion chromatography. Histidine 32-35 transient receptor potential cation channel, subfamily V, member 4 Rattus norvegicus 25-30 20044482-3 2010 Hexahistidine-tagged rat TRPV4 (His-rTRPV4) was solubilized with detergent and purified through affinity chromatography and size-exclusion chromatography. Histidine 32-35 transient receptor potential cation channel, subfamily V, member 4 Rattus norvegicus 36-42 20044482-4 2010 Chemical cross-linking analysis revealed that detergent-solubilized His-rTRPV4 was a tetramer. Histidine 68-71 transient receptor potential cation channel, subfamily V, member 4 Rattus norvegicus 72-78 20374851-2 2010 We have shown that myosin is soluble in a low ionic strength solution containing L-histidine. Histidine 81-92 myosin heavy chain 14 Homo sapiens 19-25 20374851-0 2010 Myosin filament depolymerizes in a low ionic strength solution containing L-histidine. Histidine 74-85 myosin heavy chain 14 Homo sapiens 0-6 20374851-3 2010 In this study, to clarify the role of L-histidine in the solubilization of myosin, we investigated effects of L-histidine on the filament formation and the morphology of myosin at a low ionic strength. Histidine 38-49 myosin heavy chain 14 Homo sapiens 75-81 20374851-4 2010 In the presence of L-histidine, myosin formed a filamentous polymer in a physiological ionic strength solution and dispersed in a low ionic strength solution. Histidine 19-30 myosin heavy chain 14 Homo sapiens 32-38 20374851-5 2010 Transmission electron microscopy showed that light meromyosin (LMM), the rod region of myosin, in a low ionic strength solution containing L-histidine was longer than that in a high ionic strength solution without L-histidine. Histidine 139-150 myosin heavy chain 14 Homo sapiens 55-61 20374851-6 2010 L-histidine causes the elongation of LMM region of myosin contributing to the weakening of the myosin filament and the dissociation of myosin in a low ionic strength solution. Histidine 0-11 myosin heavy chain 14 Homo sapiens 51-57 20374851-6 2010 L-histidine causes the elongation of LMM region of myosin contributing to the weakening of the myosin filament and the dissociation of myosin in a low ionic strength solution. Histidine 0-11 myosin heavy chain 14 Homo sapiens 95-101 20113314-8 2010 Substituting the histidine residue at position 3 in human hepcidin-25 and comparably the asparagine residue at position 3 in murine hepcidin-25 with an alanine residue markedly diminished the affinity for copper. Histidine 17-26 hepcidin antimicrobial peptide Homo sapiens 58-66 19828673-2 2010 In adult ventricular cell pairs, localized cellular pHi disturbances are removed by sarcolemmal acid/base transporters, but can also be dissipated (diluted) across gap junctions, aboard mobile buffers such as CO2/HCO3- and histidine-containing dipeptides (HCDPs). Histidine 223-232 glucose-6-phosphate isomerase Rattus norvegicus 52-55 19319663-2 2010 Using this system, we recently reported the overproduction of histidine-tagged mouse estrogen receptor (ER) alpha-ligand binding domain as an intact 30 kD protein and its inhibitory effect on the growth of bacteria. Histidine 62-71 estrogen receptor 1 (alpha) Mus musculus 85-102 19319663-2 2010 Using this system, we recently reported the overproduction of histidine-tagged mouse estrogen receptor (ER) alpha-ligand binding domain as an intact 30 kD protein and its inhibitory effect on the growth of bacteria. Histidine 62-71 estrogen receptor 1 (alpha) Mus musculus 104-106 20025906-5 2010 Conserved residues in the predicted transmembrane domains II, IV, V and VII of LIT1 are essential for iron transport in yeast, including histidines that were proposed to function as metal ligands in ZIP transporters. Histidine 137-147 phosphatidylinositol 4,5-bisphosphate-binding protein Saccharomyces cerevisiae S288C 79-83 20586183-11 2010 The results indicated that the fusion of GAPDH with the N-terminally His-tagged form gave rise to the accumulation of an expected 43 kDa polypeptide. Histidine 69-72 glyceraldehyde-3-phosphate dehydrogenase Ailuropoda melanoleuca 41-46 19953505-0 2010 pH-dependent stability of neuroserpin is mediated by histidines 119 and 138; implications for the control of beta-sheet A and polymerization. Histidine 53-63 serpin family I member 1 Homo sapiens 26-37 20058234-3 2010 The small thiol-group-specific reagent N-ethylmaleimide (NEM) was used to modify the cysteine residues in GalP(His)(6) both alone and in the presence of D-glucose, a known substrate. Histidine 111-114 galanin like peptide Homo sapiens 106-110 19566844-6 2010 Intracerebroventricular injection of L-histidine (0.01 microg / 5 microL) also caused a decrease in MAP, which was reversed by cotreatment with the histamine H3 receptor antagonist thioperamide (20.4 microg / 5 microL, i.c.v.). Histidine 37-48 histamine receptor H3 Rattus norvegicus 148-169 19566844-16 2010 These results suggest that L-histidine decreases blood pressure by attenuating sympathetic output via the central histamine H3 receptor in SHR. Histidine 27-38 histamine receptor H3 Rattus norvegicus 114-135 20946858-0 2010 Reversible histidine phosphorylation in mammalian cells: a teeter-totter formed by nucleoside diphosphate kinase and protein histidine phosphatase 1. Histidine 11-20 cytidine/uridine monophosphate kinase 2 Homo sapiens 83-112 20946858-4 2010 Herein, we describe the analysis of the phosphorylation and dephosphorylation of histidine residues by NDPK and PHPT-1. Histidine 81-90 cytidine/uridine monophosphate kinase 2 Homo sapiens 103-107 20061554-4 2010 The interactions between DDB1 and COP1, SPA1, and SPA3 were disrupted by mutations in the WDXR motifs of MBP-COP1, His-SPA1, and His-SPA3. Histidine 115-118 SPA1-related 3 Arabidopsis thaliana 50-54 20061554-4 2010 The interactions between DDB1 and COP1, SPA1, and SPA3 were disrupted by mutations in the WDXR motifs of MBP-COP1, His-SPA1, and His-SPA3. Histidine 129-132 SPA1-related 3 Arabidopsis thaliana 50-54 20061554-4 2010 The interactions between DDB1 and COP1, SPA1, and SPA3 were disrupted by mutations in the WDXR motifs of MBP-COP1, His-SPA1, and His-SPA3. Histidine 129-132 SPA1-related 3 Arabidopsis thaliana 133-137 19682287-8 2009 However, the FAD4 protein contains two histidine motifs resembling those of metalloproteins such as fatty acid desaturases. Histidine 39-48 fatty acid desaturase A Arabidopsis thaliana 13-17 19669174-0 2009 Reactivity of platinum-based antitumor drugs towards a Met- and His-rich 20mer peptide corresponding to the N-terminal domain of human copper transporter 1. Histidine 64-67 solute carrier family 31 member 1 Homo sapiens 135-155 19669174-3 2009 In the work reported here, we constructed a Met- and His-rich 20mer peptide (hCtr1-N20) corresponding to the N-terminal domain of hCtr1, which is the essential domain of hCtr1 for transporting platinum drugs. Histidine 53-56 solute carrier family 31 member 1 Homo sapiens 77-82 19669174-3 2009 In the work reported here, we constructed a Met- and His-rich 20mer peptide (hCtr1-N20) corresponding to the N-terminal domain of hCtr1, which is the essential domain of hCtr1 for transporting platinum drugs. Histidine 53-56 solute carrier family 31 member 1 Homo sapiens 130-135 19669174-3 2009 In the work reported here, we constructed a Met- and His-rich 20mer peptide (hCtr1-N20) corresponding to the N-terminal domain of hCtr1, which is the essential domain of hCtr1 for transporting platinum drugs. Histidine 53-56 solute carrier family 31 member 1 Homo sapiens 130-135 19559727-7 2009 The soluble Fab fragments, expressed in Escherichia coli were purified by a single step Nickel-NTA affinity chromatography via a hexa-histidine tag and their binding specificities to rabies virus were confirmed. Histidine 134-143 FA complementation group B Homo sapiens 12-15 19101821-11 2009 The results indicated that the RPS25 gene can be really expressed in E. coli and the RPS25 protein fusioned with the N-terminally his-tagged form gave rise to the accumulation of an expected 17.4 kDa polypeptide. Histidine 130-133 40S ribosomal protein S25 Ailuropoda melanoleuca 31-36 19101821-11 2009 The results indicated that the RPS25 gene can be really expressed in E. coli and the RPS25 protein fusioned with the N-terminally his-tagged form gave rise to the accumulation of an expected 17.4 kDa polypeptide. Histidine 130-133 40S ribosomal protein S25 Ailuropoda melanoleuca 85-90 19764800-8 2009 Protein-electrode orientation and efficient intraheme ET enable the His,OH(-)-ligated heme A of the immobilized Met64Ala variant to carry out the reductive electrocatalysis of molecular oxygen. Histidine 68-71 hemE Pseudoalteromonas haloplanktis TAC125 49-53 19684018-6 2009 Using a series of hCTR1 mutants, we show that cleavage occurs preferentially between residues Ala(29)-Ser(30)-His(31). Histidine 110-113 solute carrier family 31 member 1 Homo sapiens 18-23 19422058-5 2009 The molecular function and structural features of SPINK2 were also investigated by employing the recombinant active and mutant inactive SPINK2 proteins to determine its key P2-P2" (Pro(23)-Arg(24)-His(25)-Phe(26)) active site. Histidine 197-200 serine peptidase inhibitor Kazal type 2 Homo sapiens 50-56 19422058-7 2009 Although His(25) at the P1" and Phe(26) at the P2" residues are also involved in trypsin-SPINK2 interaction, Pro(23) at the P2 site may not be directly participated in interacting with trypsin. Histidine 9-12 serine peptidase inhibitor Kazal type 2 Homo sapiens 89-95 19736979-1 2009 CW EPR spectra of reduced [2Fe-2S](Cys)(3)(His)(1) clusters of mammalian mitoNEET soluble domain appear to produce features resulting from the interaction of the electron spins of the two adjacent clusters, which can be explained by employing the local spin model. Histidine 43-46 CDGSH iron sulfur domain 1 Homo sapiens 73-81 19487247-1 2009 An N-terminal domain histidine [corresponding to position 39 of UDP-glucuronosyltransferase (UGT) 1A1] is conserved in all UGT1A and UGT2B subfamily proteins except UGT1A4 (Pro-40) and UGT2B10 (Leu-34). Histidine 21-30 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 165-171 19487247-1 2009 An N-terminal domain histidine [corresponding to position 39 of UDP-glucuronosyltransferase (UGT) 1A1] is conserved in all UGT1A and UGT2B subfamily proteins except UGT1A4 (Pro-40) and UGT2B10 (Leu-34). Histidine 21-30 UDP glucuronosyltransferase family 2 member B10 Homo sapiens 185-192 19487247-5 2009 The conserved N-terminal domain histidine of UGT1A1, UGT1A6, UGT1A9, and UGT2B7 was mutated to proline and leucine 34 of UGT2B10 was substituted with histidine, and the capacity of the wild-type and mutant proteins to glucuronidate 4MU, 1NP, LTG, TFP, and naproxen was characterized. Histidine 32-41 UDP glucuronosyltransferase family 2 member B10 Homo sapiens 121-128 19487247-5 2009 The conserved N-terminal domain histidine of UGT1A1, UGT1A6, UGT1A9, and UGT2B7 was mutated to proline and leucine 34 of UGT2B10 was substituted with histidine, and the capacity of the wild-type and mutant proteins to glucuronidate 4MU, 1NP, LTG, TFP, and naproxen was characterized. Histidine 150-159 UDP glucuronosyltransferase family 2 member B10 Homo sapiens 121-128 19399589-3 2009 Here, we show in human, mouse and sheep airway membranes, that the phosphorylation state of membrane-bound NDPK on histidine and serine residues differs dependent on many regulatory factors. Histidine 115-124 cytidine/uridine monophosphate kinase 2 Homo sapiens 107-111 19706422-3 2009 EPR, Mossbauer, and XAS spectroscopic results presented herein provide direct spectroscopic evidence that hDOHH has an antiferromagnetically coupled diiron center with histidines and carboxylates as likely ligands, as suggested by mutagenesis experiments. Histidine 168-178 deoxyhypusine hydroxylase Homo sapiens 106-111 19716620-4 2009 Furthermore, we find that cox1 expression involves U-to-C editing, reconstituting an otherwise invariant, essential histidine involved in copper binding. Histidine 116-125 mitochondrially encoded cytochrome c oxidase I Homo sapiens 26-30 19501583-5 2009 A point mutation resulting in a leucine-to-histidine change was detected in the thrombospondin domain of the col9alpha1 gene in prp. Histidine 43-52 collagen, type XXII, alpha 1 Danio rerio 128-131 19728931-6 2009 In this study, mouse FADD (80-205) containing DD domain and C-terminal region, designated as C-FADD, was expressed in E. coli with His-tag at the N-terminus and purified by Ni2+ affinity chromatography. Histidine 131-134 Fas (TNFRSF6)-associated via death domain Mus musculus 21-25 19728931-6 2009 In this study, mouse FADD (80-205) containing DD domain and C-terminal region, designated as C-FADD, was expressed in E. coli with His-tag at the N-terminus and purified by Ni2+ affinity chromatography. Histidine 131-134 Fas (TNFRSF6)-associated via death domain Mus musculus 95-99 19728931-8 2009 In vitro His-tag pull-down assay demonstrated that the purified C-FADD possessed the CK Ialpha-binding activity which was important for its non-apoptotic function. Histidine 9-12 Fas (TNFRSF6)-associated via death domain Mus musculus 66-70 18694828-7 2008 A conserved loop and histidine residue in the sequences of OMCI, TSGP2 and TSGP3 are implicated in the interaction with complement C5. Histidine 21-30 complement C5 Homo sapiens 120-133 18571500-1 2008 A histidine-tagged recombinant N-terminal fragment of type-1 mouse liver diacylglycerol acyltransferase (DGAT; EC 2.3.1.20), MmDGAT1(1-95)His6, was expressed in Escherichia coli, and used to investigate possible acyl-CoA-binding properties. Histidine 2-11 diacylglycerol O-acyltransferase 1 Mus musculus 73-103 18571500-1 2008 A histidine-tagged recombinant N-terminal fragment of type-1 mouse liver diacylglycerol acyltransferase (DGAT; EC 2.3.1.20), MmDGAT1(1-95)His6, was expressed in Escherichia coli, and used to investigate possible acyl-CoA-binding properties. Histidine 2-11 diacylglycerol O-acyltransferase 1 Mus musculus 105-109 18600814-4 2008 The reactivity achieved with the HJ1 polypeptide, rationally designed to catalyze the hydrolysis of phosphodiesters, is based on two histidine residues flanked by four arginines and two adjacent tyrosine residues, all located on the surface of a helix-loop-helix motif. Histidine 133-142 jagged canonical Notch ligand 1 Homo sapiens 33-36 18460012-1 2008 Diphthamide is a post-translational derivative of histidine in protein synthesis elongation factor-2 (eEF-2) that is present in all eukaryotes with no known normal physiological role. Histidine 50-59 eukaryotic translation elongation factor 2 Homo sapiens 81-100 18680512-2 2008 The isotypic residues at position 1101-1106 of the C4A gene contain the Pro-Cys-Pro-Val-Leu-Asp sequence which has a higher affinity for binding amino group-containing antigens, while C4B contains the Leu-Ser-Pro-Val-Ileu-His sequence which has a higher affinity for hydroxyl group-containing antigens. Histidine 222-225 complement C4A (Rodgers blood group) Homo sapiens 51-54 18463094-7 2008 Using liquid chromatography-mass spectroscopy and a VTC2-H238N mutant, we provide evidence that the reaction proceeds through a covalent guanylylated histidine residue within the histidine triad motif. Histidine 150-159 GDP-L-galactose phosphorylase 1 Arabidopsis thaliana 52-56 18463094-7 2008 Using liquid chromatography-mass spectroscopy and a VTC2-H238N mutant, we provide evidence that the reaction proceeds through a covalent guanylylated histidine residue within the histidine triad motif. Histidine 179-188 GDP-L-galactose phosphorylase 1 Arabidopsis thaliana 52-56 18318660-10 2008 Exchanging His(99) of human uPA by a tyrosine residue, the corresponding residue in murine uPA, conferred mupain-1 susceptibility on to the latter. Histidine 11-14 plasminogen activator, urokinase Mus musculus 91-94 18465874-8 2008 The presence in PfFKBD of Cys-106 and Ser-109 (substituting for His-87 and Ile-90, respectively, in human FKBP12), which are 4-5 A from the nearest atom of the FK506 compound, suggests possible routes for the rational design of analogues of FK506 with specific antiparasitic activity. Histidine 64-67 FKBP prolyl isomerase 1A pseudogene 4 Homo sapiens 106-112 18561273-5 2008 Injection of His(6)-tagged very low density lipoprotein receptor (VLDLR-His(6)) constructs resulted in specific, oriented binding to the Ni(2+)-loaded bis-(nitrolotriacetic acid) (bis-NTA) groups to the re-exposed SAM areas. Histidine 13-16 very low density lipoprotein receptor Homo sapiens 27-64 18561273-5 2008 Injection of His(6)-tagged very low density lipoprotein receptor (VLDLR-His(6)) constructs resulted in specific, oriented binding to the Ni(2+)-loaded bis-(nitrolotriacetic acid) (bis-NTA) groups to the re-exposed SAM areas. Histidine 13-16 very low density lipoprotein receptor Homo sapiens 66-71 18437283-7 2008 The constructed model showed a typical alpha/beta-hydrolase fold, and confirmed the presence of a canonical catalytic triad consisting of Ser, Asp and His. Histidine 151-154 PSHA_RS05245 Pseudoalteromonas haloplanktis TAC125 39-59 18370410-2 2008 Here, we address the role of the conserved active site Ser167 residue in human IDO (S167A and S167H variants), which is replaced with a histidine in other mammalian and bacterial TDO enzymes. Histidine 136-145 indoleamine 2,3-dioxygenase 1 Homo sapiens 79-82 18302339-6 2008 We found that the work of adhesion between PIP 2-bound ezrin and F-actin is substantially larger than that measured between F-actin and ezrin bound to the membrane via the His tag. Histidine 172-175 ezrin Homo sapiens 55-60 18302339-6 2008 We found that the work of adhesion between PIP 2-bound ezrin and F-actin is substantially larger than that measured between F-actin and ezrin bound to the membrane via the His tag. Histidine 172-175 ezrin Homo sapiens 136-141 18247577-4 2008 Mutating any of the four conserved histidine residues (His51, 147, 210, or 354) in hSVCT1 to alanine did not affect the apical membrane localization in polarized MDCK cells. Histidine 35-44 solute carrier family 23 member 1 Homo sapiens 83-89 18042043-7 2008 Final proof that the ORF encoded UROS came from the fact that the recombinant protein expressed with an N-terminal histidine-tag was found to have UROS activity. Histidine 115-124 uroporphyrinogen-III synthase family protein Arabidopsis thaliana 33-37 18042043-7 2008 Final proof that the ORF encoded UROS came from the fact that the recombinant protein expressed with an N-terminal histidine-tag was found to have UROS activity. Histidine 115-124 uroporphyrinogen-III synthase family protein Arabidopsis thaliana 147-151 18194362-2 2008 This allele is identical to the HLA-B*570101 allele except for two point mutations in exon 3 at codon 138 (ACG-->ACC) with no amino acid change [persisting threonine (T)] and at codon 171 (TAC-->CAC), resulting in an amino acid change from tyrosine (Y) to histidine (H). Histidine 262-271 major histocompatibility complex, class I, B Homo sapiens 32-37 20641593-0 2004 (99m)Tc-Anti-ED-B fibronectin single-chain antibody fragment L19-His (99m)Tc-Anti-ED-B fibronectin single-chain antibody fragment L19-His ((99m)Tc-L19-His) is a radiolabeled molecular imaging agent developed for single-photon emission computed tomography (SPECT) imaging of tumor angiogenesis and guidance for antiangiogenic treatment (1). Histidine 65-68 skull development traits QTL 11 Mus musculus 61-64 20641593-0 2004 (99m)Tc-Anti-ED-B fibronectin single-chain antibody fragment L19-His (99m)Tc-Anti-ED-B fibronectin single-chain antibody fragment L19-His ((99m)Tc-L19-His) is a radiolabeled molecular imaging agent developed for single-photon emission computed tomography (SPECT) imaging of tumor angiogenesis and guidance for antiangiogenic treatment (1). Histidine 65-68 skull development traits QTL 11 Mus musculus 130-133 20641593-0 2004 (99m)Tc-Anti-ED-B fibronectin single-chain antibody fragment L19-His (99m)Tc-Anti-ED-B fibronectin single-chain antibody fragment L19-His ((99m)Tc-L19-His) is a radiolabeled molecular imaging agent developed for single-photon emission computed tomography (SPECT) imaging of tumor angiogenesis and guidance for antiangiogenic treatment (1). Histidine 65-68 skull development traits QTL 11 Mus musculus 130-133 20641593-20 2004 (1) genetically introduced a (His)6 peptide sequence at the C-terminus of L19 to produce L19-His molecules. Histidine 30-33 skull development traits QTL 11 Mus musculus 74-77 20641593-20 2004 (1) genetically introduced a (His)6 peptide sequence at the C-terminus of L19 to produce L19-His molecules. Histidine 30-33 skull development traits QTL 11 Mus musculus 89-92 17526865-4 2007 In the passive smoking group, there was a remarkable decrease in birth weight with the C/C6235 genotype (156.3 g, 95% confidence interval (CI): -283.6, -29.0) for CYP1A1 MspI and with Tyr/His113 (93.8 g, 95% CI: -188.6, -1.1) as compared with His/His113 (244.6 g, 95% CI: -491.0, -1.9) for EPHX1. Histidine 188-191 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 163-169 17526865-5 2007 When results were stratified by maternal genotype, passive smoking conferred a significantly negative effect in the EPHX1 Tyr/His113 group (103.5 g, 95% CI: -205.8, -9.2) and in the His/His113 group (687.3 g, 95% CI: -748.3, -178.3). Histidine 126-129 epoxide hydrolase 1 Homo sapiens 116-121 17670971-3 2007 Here, we demonstrate that reducing agents as well as endogenous metal chelators sensitize C-type dorsal root ganglion nociceptors by chelating Zn2+ ions off specific extracellular histidine residues on Ca(v)3.2 T-channels, thus relieving tonic channel inhibition, enhancing Ca(v)3.2 currents, and lowering the threshold for nociceptor excitability in vitro and in vivo. Histidine 180-189 immunoglobulin lambda variable 7-43 Homo sapiens 202-210 17670971-3 2007 Here, we demonstrate that reducing agents as well as endogenous metal chelators sensitize C-type dorsal root ganglion nociceptors by chelating Zn2+ ions off specific extracellular histidine residues on Ca(v)3.2 T-channels, thus relieving tonic channel inhibition, enhancing Ca(v)3.2 currents, and lowering the threshold for nociceptor excitability in vitro and in vivo. Histidine 180-189 immunoglobulin lambda variable 7-43 Homo sapiens 274-282 17493829-5 2007 Here we report successful tri-cistronic cloning, overexpression and purification of this three-protein complex using a single hexa-histidine tag. Histidine 131-140 tRNA-Ile (anticodon AAT) 9-1 Homo sapiens 26-29 17567089-1 2007 A series of myoglobin mutants, in which distal sites are modified by site-directed mutagenesis, are able to catalyze peroxidase, catalase, and P450 reactions even though their proximal histidine ligands are intact. Histidine 185-194 myoglobin Homo sapiens 12-21 17479226-6 2007 The results demonstrated that 4 x Ala, 4 x His, 4 x Gln, and 4 x Cys produced over 200% of the yield of wild-type GST. Histidine 43-46 glutathione S-transferase kappa 1 Homo sapiens 114-117 17473281-10 2007 From these two defined interactions, we predicted the complete INSL3/LGR8 primary binding site, including interactions between INSL3 His-B12 and LGR8 Trp-177, INSL3 Val-B19 and LGR8 Ile-179, and INSL3 Arg-B20 with LGR8 Asp-181 and Glu-229. Histidine 133-136 insulin like 3 Homo sapiens 63-68 17473281-10 2007 From these two defined interactions, we predicted the complete INSL3/LGR8 primary binding site, including interactions between INSL3 His-B12 and LGR8 Trp-177, INSL3 Val-B19 and LGR8 Ile-179, and INSL3 Arg-B20 with LGR8 Asp-181 and Glu-229. Histidine 133-136 relaxin family peptide receptor 2 Homo sapiens 69-73 17473281-10 2007 From these two defined interactions, we predicted the complete INSL3/LGR8 primary binding site, including interactions between INSL3 His-B12 and LGR8 Trp-177, INSL3 Val-B19 and LGR8 Ile-179, and INSL3 Arg-B20 with LGR8 Asp-181 and Glu-229. Histidine 133-136 insulin like 3 Homo sapiens 127-132 17473281-10 2007 From these two defined interactions, we predicted the complete INSL3/LGR8 primary binding site, including interactions between INSL3 His-B12 and LGR8 Trp-177, INSL3 Val-B19 and LGR8 Ile-179, and INSL3 Arg-B20 with LGR8 Asp-181 and Glu-229. Histidine 133-136 relaxin family peptide receptor 2 Homo sapiens 145-149 17473281-10 2007 From these two defined interactions, we predicted the complete INSL3/LGR8 primary binding site, including interactions between INSL3 His-B12 and LGR8 Trp-177, INSL3 Val-B19 and LGR8 Ile-179, and INSL3 Arg-B20 with LGR8 Asp-181 and Glu-229. Histidine 133-136 insulin like 3 Homo sapiens 127-132 17473281-10 2007 From these two defined interactions, we predicted the complete INSL3/LGR8 primary binding site, including interactions between INSL3 His-B12 and LGR8 Trp-177, INSL3 Val-B19 and LGR8 Ile-179, and INSL3 Arg-B20 with LGR8 Asp-181 and Glu-229. Histidine 133-136 relaxin family peptide receptor 2 Homo sapiens 145-149 17473281-10 2007 From these two defined interactions, we predicted the complete INSL3/LGR8 primary binding site, including interactions between INSL3 His-B12 and LGR8 Trp-177, INSL3 Val-B19 and LGR8 Ile-179, and INSL3 Arg-B20 with LGR8 Asp-181 and Glu-229. Histidine 133-136 insulin like 3 Homo sapiens 127-132 17473281-10 2007 From these two defined interactions, we predicted the complete INSL3/LGR8 primary binding site, including interactions between INSL3 His-B12 and LGR8 Trp-177, INSL3 Val-B19 and LGR8 Ile-179, and INSL3 Arg-B20 with LGR8 Asp-181 and Glu-229. Histidine 133-136 relaxin family peptide receptor 2 Homo sapiens 145-149 17559587-2 2007 This allele is identical to the HLA-B*3503 allele except for one point mutation in exon 4 at codon 188 (CAC-->CGC), resulting in an amino acid change from histidine to arginine. Histidine 158-167 major histocompatibility complex, class I, B Homo sapiens 32-37 17454001-4 2007 Analysis of amino acid sequence revealed conserved residues of cysteine, histidine, asparagine, occluding loop pattern, hemoglobinase motif and glutamine of the oxyanion hole characteristic of cathepsin B like proteases (CBL). Histidine 73-82 Cbl proto-oncogene Homo sapiens 193-219 17339136-0 2007 Effect of surface histidine mutations and their number on the partitioning and refolding of recombinant human granulocyte-colony stimulating factor (Cys17Ser) in aqueous two-phase systems containing chelated metal ions. Histidine 18-27 colony stimulating factor 3 Homo sapiens 110-147 17339136-4 2007 In this work, the effect of surface histidine mutations and their number on the partitioning and refolding of recombinant human granulocyte-colony stimulating factor Cys17Ser variant (rhG-CSF (C17S)) from solubilized inclusion bodies in aqueous two-phase systems polyethylene glycol (PEG)-dextran, containing metal ions, chelated by dye Light Resistant Yellow 2KT (LR Yellow 2KT)-PEG derivative, was investigated. Histidine 36-45 colony stimulating factor 3 Homo sapiens 128-165 17542813-4 2007 When expressed in X-ALD fibroblasts lacking ALDP, the expression level of mutant His-ALDPs (S606L, R617H, and H667D) was lower than that of wild type and other mutant ALDPs. Histidine 81-84 ATP binding cassette subfamily D member 1 Homo sapiens 44-48 17542813-9 2007 In addition, mutant His-ALDP (Y174C), which has a mutation between transmembrane domain 2 and 3, did not exhibit peroxisomal localization by immunofluorescense study. Histidine 20-23 ATP binding cassette subfamily D member 1 Homo sapiens 24-28 17455907-9 2007 A full-length DGKepsilon with a C-terminal His tag exhibited substrate specificity similar to that of the other two forms of the enzyme, indicating that the nature and position of the epitope tag did not strongly affect this property. Histidine 43-46 diacylglycerol kinase epsilon Homo sapiens 14-24 17510397-1 2007 There is accumulating evidence that histidine triad (HIT) nucleotide-binding protein 1 (HINT1), a member of the evolutionary highly conserved HIT protein super family, is a novel tumor suppressor. Histidine 36-45 NUBP iron-sulfur cluster assembly factor 1, cytosolic Homo sapiens 58-86 17477873-8 2007 RESULTS: Bioinformatic analysis of the Heterosigma akashiwo chloroplast genome sequence revealed the presence of a single two-component His-to-Asp (designated Tsg1/Trg1) pair in this stramenopile (golden-brown alga). Histidine 136-139 ycf26 Heterosigma akashiwo 159-163 17213471-8 2007 We conclude that SMS completely prevented HG/HI-induced TF activation in normal volunteers and may be of use to reduce the procoagulant state and acute vascular events in hyperinsulinemic insulin-resistant patients with type 2 diabetes. Histidine 45-47 coagulation factor III, tissue factor Homo sapiens 56-58 17439156-8 2007 This is attributed to the fact that that low pH results in the protonation of the side chains of Asp, Glu, and His residues, which further disrupts the following four salt-bridge interactions stabilizing the alpha-beta interface of the native structure: Asp15-Arg53 (beta1-beta2), Glu21/20-Lys54 (helix-beta2), Asp40-Arg70 (helix-AS), and His43-Asp81 (beta2-AS). Histidine 111-114 neuronal differentiation 1 Homo sapiens 273-278 17439156-8 2007 This is attributed to the fact that that low pH results in the protonation of the side chains of Asp, Glu, and His residues, which further disrupts the following four salt-bridge interactions stabilizing the alpha-beta interface of the native structure: Asp15-Arg53 (beta1-beta2), Glu21/20-Lys54 (helix-beta2), Asp40-Arg70 (helix-AS), and His43-Asp81 (beta2-AS). Histidine 111-114 neuronal differentiation 1 Homo sapiens 303-308 17439156-8 2007 This is attributed to the fact that that low pH results in the protonation of the side chains of Asp, Glu, and His residues, which further disrupts the following four salt-bridge interactions stabilizing the alpha-beta interface of the native structure: Asp15-Arg53 (beta1-beta2), Glu21/20-Lys54 (helix-beta2), Asp40-Arg70 (helix-AS), and His43-Asp81 (beta2-AS). Histidine 111-114 neuronal differentiation 1 Homo sapiens 303-308 17164245-0 2007 Electron nuclear double resonance differentiates complementary roles for active site histidines in (6-4) photolyase. Histidine 85-95 6-4 photolyase Xenopus laevis 100-115 17164245-5 2007 Shifts in the hyperfine couplings as a function of structural modifications induced by point mutations and pH changes distinguish the protonation states of two highly conserved histidines, His(354) and His(358), in Xenopus laevis (6-4) photolyase. Histidine 177-187 6-4 photolyase Xenopus laevis 231-246 17164245-5 2007 Shifts in the hyperfine couplings as a function of structural modifications induced by point mutations and pH changes distinguish the protonation states of two highly conserved histidines, His(354) and His(358), in Xenopus laevis (6-4) photolyase. Histidine 189-192 6-4 photolyase Xenopus laevis 231-246 17164245-5 2007 Shifts in the hyperfine couplings as a function of structural modifications induced by point mutations and pH changes distinguish the protonation states of two highly conserved histidines, His(354) and His(358), in Xenopus laevis (6-4) photolyase. Histidine 202-205 6-4 photolyase Xenopus laevis 231-246 17593742-3 2007 Studies on protein sequences and on synthesized peptides revealed that a histidine-containing sequence had specific interactions with precious metal ions (Au3+ and Pd2+). Histidine 73-82 PAF1 homolog, Paf1/RNA polymerase II complex component Homo sapiens 164-167 17260955-9 2007 This interaction was confirmed with pulldown analyses in which the GST-PerCter protein selectively pulled down His-MREG and His-MREG selectively pulled down PerCter. Histidine 111-114 melanoregulin Homo sapiens 115-119 17260955-9 2007 This interaction was confirmed with pulldown analyses in which the GST-PerCter protein selectively pulled down His-MREG and His-MREG selectively pulled down PerCter. Histidine 124-127 melanoregulin Homo sapiens 128-132 17108049-6 2007 Similar to the case for the Escherichia coli and human UNG enzymes, His-BKRF3 excised uracil from single-stranded DNA more efficiently than from double-stranded DNA and was inhibited by the purified bacteriophage PBS1 inhibitor Ugi. Histidine 68-71 uracil-DNA glycosylase Human gammaherpesvirus 4 72-77 17143275-0 2007 HLA-DM targets the hydrogen bond between the histidine at position beta81 and peptide to dissociate HLA-DR-peptide complexes. Histidine 45-54 major histocompatibility complex, class II, DM alpha Homo sapiens 0-6 16908189-6 2007 Addition of both the long and short N-terminal his-tags slows the refolding kinetics of FKBP-12. Histidine 47-50 FKBP prolyl isomerase 1A pseudogene 4 Homo sapiens 88-95 17068338-6 2006 We found that alterations at Glu(632) and His(661) of TAP2 significantly reduced peptide translocation and/or TAP-induced major histocompatibility complex class I surface expression. Histidine 42-45 filamin B Homo sapiens 54-57 17052986-0 2006 Seeing the process of histidine phosphorylation in human bisphosphoglycerate mutase. Histidine 22-31 bisphosphoglycerate mutase Homo sapiens 57-83 17040910-4 2006 Four conserved residues in the C-terminal loop of DPP8 (Phe(822), Val(833), Tyr(844), and His(859)), corresponding to those located at the dimer interface of DPP-IV, were individually mutated to Ala. Histidine 90-93 dipeptidyl peptidase 4 Homo sapiens 158-164 17023418-6 2006 The differential binding of AhR by Arnt and Arnt2 can be ascribed to a single His/Pro amino acid difference in the PASB region of Arnt and Arnt2, suggesting that the PASB/PASB interaction between bHLH-PAS transcription factors plays a selective role for their specific partner molecule. Histidine 78-81 aryl hydrocarbon receptor nuclear translocator Homo sapiens 35-39 17023418-6 2006 The differential binding of AhR by Arnt and Arnt2 can be ascribed to a single His/Pro amino acid difference in the PASB region of Arnt and Arnt2, suggesting that the PASB/PASB interaction between bHLH-PAS transcription factors plays a selective role for their specific partner molecule. Histidine 78-81 aryl hydrocarbon receptor nuclear translocator 2 Homo sapiens 44-49 17023418-6 2006 The differential binding of AhR by Arnt and Arnt2 can be ascribed to a single His/Pro amino acid difference in the PASB region of Arnt and Arnt2, suggesting that the PASB/PASB interaction between bHLH-PAS transcription factors plays a selective role for their specific partner molecule. Histidine 78-81 aryl hydrocarbon receptor nuclear translocator Homo sapiens 44-48 17023418-6 2006 The differential binding of AhR by Arnt and Arnt2 can be ascribed to a single His/Pro amino acid difference in the PASB region of Arnt and Arnt2, suggesting that the PASB/PASB interaction between bHLH-PAS transcription factors plays a selective role for their specific partner molecule. Histidine 78-81 aryl hydrocarbon receptor nuclear translocator 2 Homo sapiens 139-144 16963788-2 2006 Analyses with various spectroscopic methods including MALDI-TOF-MS indicated that two axial His residues (His44 and His68) of cytochrome b(5) were protected from the modification by several factors, i.e., limited steric exposure of the axial imidazole to the solvent, the Fe-N(epsilon2) coordination bond, and protonation of the N(delta1) position by forming a hydrogen bond with its immediate surroundings. Histidine 92-95 cytochrome b5 type A Homo sapiens 126-141 17021082-2 2006 In order to facilitate armored RNA purification, a His6 tag was introduced into the loop region of the MS2 coat protein, which allows the exposure of multiple His tags on the surface during armored RNA assembly. Histidine 51-54 MS2 Homo sapiens 103-106 16967187-8 2006 All these findings suggested that the fused expressed His-DR inhibited the activity of natural DDR2, and relevant MMP-1 and MMP-2 expression in synoviocytes and NIH3T3 cells provoked by collagen II. Histidine 54-57 discoidin domain receptor family, member 2 Mus musculus 95-99 16931876-3 2006 We describe the 3 A resolution crystal structure of the highly conserved cysteine-histidine-rich domain of human UPF1 and show that it is a unique combination of three zinc-binding motifs arranged into two tandem modules related to the RING-box and U-box domains of ubiquitin ligases. Histidine 82-91 UPF1 RNA helicase and ATPase Homo sapiens 113-117 16310386-5 2006 Primary (Val(87), Phe(90)) and secondary (Asn(92), Ile(93), Thr(95)) MHC anchors occupy the same region in space, whereas T-cell receptor (TCR) contacts (His(88), Phe(89)) have different orientation between the two structures. Histidine 154-157 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 122-137 16310386-5 2006 Primary (Val(87), Phe(90)) and secondary (Asn(92), Ile(93), Thr(95)) MHC anchors occupy the same region in space, whereas T-cell receptor (TCR) contacts (His(88), Phe(89)) have different orientation between the two structures. Histidine 154-157 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 139-142 16518858-5 2006 TAA90K-His bound to fibronectin, collagen IV, laminins-1, -5, and -10 and galectin-3 (Mac-2) but poorly to collagen I and galectin-1. Histidine 7-10 galectin 3 binding protein Homo sapiens 0-6 16518858-8 2006 However, at low concentrations, TAA90K-His enhanced galectin-3-mediated HT-29 cell adhesion while at high concentrations, it inhibited cell adhesion. Histidine 39-42 galectin 3 binding protein Homo sapiens 32-38 16717093-2 2006 An important feature of the nucleotide exchange is the structural rearrangement of EF-Tu in the EF-Tu.EF-Ts complex caused by insertion of Phe-81 of EF-Ts between His-84 and His-118 of EF-Tu. Histidine 163-166 Ts translation elongation factor, mitochondrial Homo sapiens 102-107 16717093-2 2006 An important feature of the nucleotide exchange is the structural rearrangement of EF-Tu in the EF-Tu.EF-Ts complex caused by insertion of Phe-81 of EF-Ts between His-84 and His-118 of EF-Tu. Histidine 163-166 Ts translation elongation factor, mitochondrial Homo sapiens 149-154 16717093-2 2006 An important feature of the nucleotide exchange is the structural rearrangement of EF-Tu in the EF-Tu.EF-Ts complex caused by insertion of Phe-81 of EF-Ts between His-84 and His-118 of EF-Tu. Histidine 174-177 Ts translation elongation factor, mitochondrial Homo sapiens 102-107 16717093-2 2006 An important feature of the nucleotide exchange is the structural rearrangement of EF-Tu in the EF-Tu.EF-Ts complex caused by insertion of Phe-81 of EF-Ts between His-84 and His-118 of EF-Tu. Histidine 174-177 Ts translation elongation factor, mitochondrial Homo sapiens 149-154 19661578-2 2006 An elastin-like-polypeptide (ELP)-based biopolymer consisting of a hexahistine cluster at each end (His(6)-ELP-His(6)) was generated and purified by taking advantage of the reversible phase transition property of ELP. Histidine 100-103 nuclear receptor subfamily 5 group A member 1 Homo sapiens 3-27 19661578-2 2006 An elastin-like-polypeptide (ELP)-based biopolymer consisting of a hexahistine cluster at each end (His(6)-ELP-His(6)) was generated and purified by taking advantage of the reversible phase transition property of ELP. Histidine 100-103 nuclear receptor subfamily 5 group A member 1 Homo sapiens 29-32 19661578-2 2006 An elastin-like-polypeptide (ELP)-based biopolymer consisting of a hexahistine cluster at each end (His(6)-ELP-His(6)) was generated and purified by taking advantage of the reversible phase transition property of ELP. Histidine 111-114 nuclear receptor subfamily 5 group A member 1 Homo sapiens 3-27 19661578-2 2006 An elastin-like-polypeptide (ELP)-based biopolymer consisting of a hexahistine cluster at each end (His(6)-ELP-His(6)) was generated and purified by taking advantage of the reversible phase transition property of ELP. Histidine 111-114 nuclear receptor subfamily 5 group A member 1 Homo sapiens 29-32 19661578-2 2006 An elastin-like-polypeptide (ELP)-based biopolymer consisting of a hexahistine cluster at each end (His(6)-ELP-His(6)) was generated and purified by taking advantage of the reversible phase transition property of ELP. Histidine 111-114 nuclear receptor subfamily 5 group A member 1 Homo sapiens 107-110 19661578-2 2006 An elastin-like-polypeptide (ELP)-based biopolymer consisting of a hexahistine cluster at each end (His(6)-ELP-His(6)) was generated and purified by taking advantage of the reversible phase transition property of ELP. Histidine 111-114 nuclear receptor subfamily 5 group A member 1 Homo sapiens 107-110 16563127-12 2006 Expression of His-C/EBPbeta-P4 in HepG2 cells significantly diminishes the OM-induced increase in LDLR promoter activity and the elevation of endogenous LDLR mRNA expression. Histidine 14-17 low density lipoprotein receptor Homo sapiens 98-102 16563127-12 2006 Expression of His-C/EBPbeta-P4 in HepG2 cells significantly diminishes the OM-induced increase in LDLR promoter activity and the elevation of endogenous LDLR mRNA expression. Histidine 14-17 low density lipoprotein receptor Homo sapiens 153-157 16595170-4 2006 Unexpectedly, the naturally occurring mutation of Arg(3.50) to His in mouse GPR33 showed no difference from the wild-type receptor in several functional tests. Histidine 63-66 G protein-coupled receptor 33 Mus musculus 76-81 16603126-5 2006 ZmPUMP was also used to investigate the importance of a histidine pair present in the second matrix loop of mammalian UCP1 and absent in plant UCPs. Histidine 56-65 uncoupling protein 1 Homo sapiens 118-122 16533814-12 2006 Our results provide strong evidence that Fe(II) is the active-site-bound metal critical for DOHH catalysis and that the strictly conserved His-Glu motifs are essential for iron binding and catalysis. Histidine 139-142 deoxyhypusine hydroxylase Homo sapiens 92-96 16533814-13 2006 Furthermore, the iron to DOHH stoichiometry and dependence of iron binding on each of the four conserved His-Glu motifs suggest a binuclear iron mediated reaction mechanism, distinct from that of other Fe(II)-dependent protein hydroxylases, such as prolyl 4-hydroxylase or lysyl hydroxylases. Histidine 105-108 deoxyhypusine hydroxylase Homo sapiens 25-29 16399879-6 2006 RESULTS: Sequence analysis of the Cct5 gene revealed a missense A492G mutation in exon 4 that results in the substitution of a highly conserved histidine for arginine amino acid 147. Histidine 144-153 chaperonin containing TCP1 subunit 5 Homo sapiens 34-38 16648478-1 2006 The translation elongation factor 2 in eukaryotes (eEF-2) contains a unique posttranslationally modified histidine residue, termed diphthamide, which serves as the only target for diphtheria toxin and Pseudomonas aeruginosa exotoxin A. Histidine 105-114 eukaryotic translation elongation factor 2 Mus musculus 51-56 16595957-1 2006 A two-step binding assay for globotriaosylceramide (Gb3) content was developed by histidine-tagging strategy, which is a well-established method for the purification of recombinant proteins. Histidine 82-91 alpha 1,4-galactosyltransferase (P blood group) Homo sapiens 52-55 16595957-2 2006 The complete binding of the recombinant His-tagged Shiga toxin 1B subunit (1B-His) (1 microg/ml) to the standard Gb3 adsorbed on a multi-well H type plate was observed within 30 min at 37 degrees C; and its binding could be visualized by the following applications of HisProbe-HRP (8 microg/ml) and tetramethylbenzidine (TMB) peroxidase substrate. Histidine 40-43 alpha 1,4-galactosyltransferase (P blood group) Homo sapiens 113-116 16755491-3 2006 The origin of this variant is a mutation in codon 47 (GAC --> CAC) of the alpha2-globin gene, resulting in the replacement of asparagine by histidine during the translation process. Histidine 143-152 glutaminase Homo sapiens 54-57 16533060-7 2006 Furthermore, when such bilayers were immobilized onto solid supports, they efficiently captured histidine-tagged soluble tissue factor directly from crude culture supernatants, with full biological activity, obviating the need for purification or laborious membrane reconstitution procedures. Histidine 96-105 coagulation factor III, tissue factor Homo sapiens 121-134 16415340-2 2006 Here, we demonstrate that the DNA-binding domain of Spt10p is located between residues 283 and 396 and includes a His(2)-Cys(2) zinc finger. Histidine 114-117 Spt10p Saccharomyces cerevisiae S288C 52-58 16371355-10 2006 Within a highly conserved motif known to be important for catalysis, human ACSBG2 contains a histidine residue where all other known acyl-CoA synthetases, including mouse and rat ACSBG2, contain an arginine. Histidine 93-102 acyl-CoA synthetase bubblegum family member 2 Homo sapiens 75-81 16371355-10 2006 Within a highly conserved motif known to be important for catalysis, human ACSBG2 contains a histidine residue where all other known acyl-CoA synthetases, including mouse and rat ACSBG2, contain an arginine. Histidine 93-102 acyl-CoA synthetase bubblegum family member 2 Rattus norvegicus 179-185 16278015-2 2006 In this study, an oligohistidine (His(6)) epitope tag was incorporated at the N-terminus of an ELP using recombinant DNA techniques to permit tracking without compromising on material biocompatibility. Histidine 34-37 nuclear receptor subfamily 5 group A member 1 Homo sapiens 95-98 16475832-5 2006 In this study, we have developed a two-step purification protocol using stably overexpressed His-tagged Cdr1p in Saccharomyces cerevisiae. Histidine 93-96 cerebellar degeneration related protein 1 Homo sapiens 104-109 16475834-10 2006 In contrast, isotope effects for association of UCH-L1 with transition-state analogue ubiquitin aldehyde suggest that an alternative mechanistic pathway can sometimes be available to UCH-L1 involving general base-catalyzed attack of Cys-SH by His-Im. Histidine 243-246 ubiquitin C-terminal hydrolase L1 Homo sapiens 48-54 16475834-10 2006 In contrast, isotope effects for association of UCH-L1 with transition-state analogue ubiquitin aldehyde suggest that an alternative mechanistic pathway can sometimes be available to UCH-L1 involving general base-catalyzed attack of Cys-SH by His-Im. Histidine 243-246 ubiquitin C-terminal hydrolase L1 Homo sapiens 183-189 16489009-2 2006 We have shown that the antiangiogenic effect of HRGP is dependent on its histidine/proline-rich domain, which needs to be released from the mother protein to exert its effects. Histidine 73-82 histidine-rich glycoprotein Mus musculus 48-52 16293613-11 2006 His-216 occupies a position similar to that of Tyr-136 in bovine rhodopsin, part of the DRY motif of the latter receptor. Histidine 0-3 rhodopsin Bos taurus 65-74 16388603-5 2006 This conserved histidine (His-135 in HST2) activates the ribose 2"-hydroxyl for attack on the alpha-1"-O-alkylamidate. Histidine 15-24 fibroblast growth factor 6 Homo sapiens 37-41 16388603-5 2006 This conserved histidine (His-135 in HST2) activates the ribose 2"-hydroxyl for attack on the alpha-1"-O-alkylamidate. Histidine 26-29 fibroblast growth factor 6 Homo sapiens 37-41 16320010-0 2006 Insights into the role of the histidines in the structure and stability of cytochrome c. Histidine 30-40 cytochrome c, somatic Equus caballus 75-87 16320010-1 2006 In this paper we investigate the role played by each histidine in the amino acid sequence of yeast iso-1-cytochrome c (with the exception of H18, the residue axially coordinated to the heme iron) in determining the protein structure and stability. Histidine 53-62 cytochrome c, somatic Equus caballus 105-117 16091957-10 2006 Our data indicate (i) that H(+) coupling in DMT1 serves to increase affinity for Fe(2+) and provide a thermodynamic driving force for Fe(2+) transport and (ii) that His-272 is critical in transducing the effects of H(+) coupling. Histidine 165-168 solute carrier family 11 member 2 Homo sapiens 44-48 16511245-2 2005 However, the products of the two alleles differ by only two amino acids, at heavy-chain residues 114 (His in HLA-B*2704; Asp in HLA-B*2706) and 116 (Asp in HLA-B*2704; Tyr in HLA-B*2706). Histidine 102-105 major histocompatibility complex, class I, B Homo sapiens 109-114 16314460-6 2005 Thus, in U4 atac snRNA we identified His 270 in the spliceosomal U4/U6 snRNP-specific protein 61 K (hPrp31p) cross-linked to U 44; in the U1 snRNP we show that Leu175 of the U1 snRNP-specific 70K protein is cross-linked to U 30 of U1 snRNA. Histidine 37-40 RNA binding region (RNP1, RRM) containing 3 Homo sapiens 174-182 16154994-9 2005 In the current study, we show that the conserved His-460 is a key active site residue for hACAT1. Histidine 49-52 acetyl-CoA acetyltransferase 1 Homo sapiens 90-96 16292933-4 2005 The role of the proximal histidine is, in particular, clearly demonstrated in the first step of the myoglobin relaxation from its liganded to it deliganded form. Histidine 25-34 myoglobin Homo sapiens 100-109 16102717-3 2005 It also allowed us to accurately determine the kinetic rate constants for the interaction between His-CypA and CsA. Histidine 98-101 peptidylprolyl isomerase A Homo sapiens 102-106 16102717-4 2005 His-CypA was first captured on a Ni2+-nitrilotriacetic acid (NTA) sensor chip and was then briefly covalently stabilized, coupling via primary amines. Histidine 0-3 peptidylprolyl isomerase A Homo sapiens 4-8 16183033-7 2005 The IC50 for proton effects was close to the pKa for histidine, suggesting conserved histidine residues present in SLC39A1 play a critical role in Zn2+ influx and are involved in the pH effect. Histidine 53-62 solute carrier family 39 member 1 Homo sapiens 115-122 16183033-7 2005 The IC50 for proton effects was close to the pKa for histidine, suggesting conserved histidine residues present in SLC39A1 play a critical role in Zn2+ influx and are involved in the pH effect. Histidine 85-94 solute carrier family 39 member 1 Homo sapiens 115-122 16195551-1 2005 Human peripheral-type cannabinoid receptor (CB2) was expressed in Escherichia coli as a fusion with the maltose-binding protein, thioredoxin, and a deca-histidine tag. Histidine 153-162 cannabinoid receptor 2 Homo sapiens 44-47 16853158-1 2005 Ultrafast protein dynamics of the CO adduct of a myoglobin mutant with the polar distal histidine replaced by a nonpolar valine (H64V) have been investigated by spectrally resolved infrared stimulated vibrational echo experiments and molecular dynamics (MD) simulations. Histidine 88-97 myoglobin Homo sapiens 49-58 15843493-2 2005 SLC38A3 is a sodium-coupled neutral amino acid transporter having substrate preference for l-glutamate, l-histidine, and l-alanine. Histidine 104-115 solute carrier family 38, member 3 Mus musculus 0-7 15919716-2 2005 We have investigated whether Hi+ mobility varies with pHi. Histidine 29-32 glucose-6-phosphate isomerase Rattus norvegicus 54-57 15919716-14 2005 One consequence of a decline in Hi+ mobility at low pHi is that it will predispose the myocardium to pHi nonuniformity. Histidine 32-35 glucose-6-phosphate isomerase Rattus norvegicus 52-55 15919716-14 2005 One consequence of a decline in Hi+ mobility at low pHi is that it will predispose the myocardium to pHi nonuniformity. Histidine 32-35 glucose-6-phosphate isomerase Rattus norvegicus 101-104 15817478-2 2005 Dopamine inhibition of alpha-syn fibrillization generated exclusively spherical oligomers that depended on dopamine autoxidation but not alpha-syn oxidation, because mutagenesis of Met, His, and Tyr residues in alpha-syn did not abrogate this inhibition. Histidine 186-189 synuclein alpha Homo sapiens 23-32 15889294-8 2005 The AtPTR3 gene was induced by the amino acids histidine, leucine and phenylalanine in cotyledons and lower leaves, whereas a strong induction was obtained in the whole plant upon exposure to salt. Histidine 47-56 peptide transporter 3 Arabidopsis thaliana 4-10 15892892-5 2005 Trz1p has two putative nucleotide triphosphate-binding motifs (P-loop) and a conserved histidine motif. Histidine 87-96 tRNase Z Saccharomyces cerevisiae S288C 0-5 15892892-6 2005 The histidine motif and the putative nucleotide binding motif at the C-domain are important for Trz1p function because mutant proteins bearing changes to the critical residues in these motifs are unable to rescue deletion of TRZ1. Histidine 4-13 tRNase Z Saccharomyces cerevisiae S288C 96-101 15977068-4 2005 As a result, DEAD (Asp-Glu-Ala-Asp/His) box polypeptide 47 (DDX 47), recently identified as RNA helicase, is identified as a binding partner of GABARAP. Histidine 35-38 DEAD-box helicase 47 Homo sapiens 60-66 15977068-4 2005 As a result, DEAD (Asp-Glu-Ala-Asp/His) box polypeptide 47 (DDX 47), recently identified as RNA helicase, is identified as a binding partner of GABARAP. Histidine 35-38 GABA type A receptor-associated protein Homo sapiens 144-151 15864132-4 2005 HuH7 human hepatoma cells were transfected with vectors encoding for the human Ala- or Val-MnSOD variants fused to a Myc-His-tag. Histidine 121-124 MYC proto-oncogene, bHLH transcription factor Homo sapiens 117-120 15802216-10 2005 To overcome the proteolysis by thrombin, C-terminal His-tagged LMP2A NTD and intein-fused LMP2A NTD were prepared. Histidine 52-55 LMP2A Human gammaherpesvirus 4 63-68 15900706-8 2005 A recombinant, C-terminally His-tagged synaptobrevin fragment bound to nickel beads specifically bound synaptophysin, syntaxin and SNAP25 from vesicular detergent extracts. Histidine 28-31 synaptosome associated protein 25 Homo sapiens 131-137 15766882-5 2005 In this study, we produced a 6 x His-tagged GST-CD38 fusion protein using a recombinant baculovirus/insect cell expression technique that was purified as a soluble protein. Histidine 33-36 CD38 molecule Homo sapiens 48-52 15741231-5 2005 Additionally, the triadic His562 residue of LDLR, which is putatively involved in ligand uncoupling, was mutated to Asn, corresponding to Asn643 in LpR, to analyse the role of the His triad in receptor functioning. Histidine 26-29 low density lipoprotein receptor Homo sapiens 44-48 15710513-2 2005 Previous research has shown that biodegradable, multiblock copolymers (MBC), PEG-PLL-g-16% His, are efficient gene carriers with negligible cellular toxicities. Histidine 91-94 progestagen associated endometrial protein Homo sapiens 77-80 15611058-4 2005 Here, we have detergent-solubilized, purified, and reconstituted enzymatically active His-tagged Ste14p from S. cerevisiae, thus providing conclusive proof that Ste14p is the sole component necessary for the carboxylmethylation of isoprenylated substrates. Histidine 86-89 protein-S-isoprenylcysteine carboxyl O-methyltransferase Saccharomyces cerevisiae S288C 97-103 15611058-4 2005 Here, we have detergent-solubilized, purified, and reconstituted enzymatically active His-tagged Ste14p from S. cerevisiae, thus providing conclusive proof that Ste14p is the sole component necessary for the carboxylmethylation of isoprenylated substrates. Histidine 86-89 protein-S-isoprenylcysteine carboxyl O-methyltransferase Saccharomyces cerevisiae S288C 161-167 15713471-8 2005 Addition of an 11 amino acid residue extension to the C terminus of P(6) also produced a dimer, whereas the P(6) labelled with a His-tag at the N terminus displayed a monomer structure. Histidine 129-132 exosome component 9 Homo sapiens 108-112 15735016-1 2005 We used gene targeting in mice to insert a His(6)-tagged mouse c-Myc cDNA, Myc(His), head to head into the mouse immunoglobulin heavy-chain locus, Igh, just 5" of the intronic enhancer, Emu. Histidine 43-46 MYC proto-oncogene, bHLH transcription factor Homo sapiens 65-68 15697300-6 2005 The thioredoxin is a recombinant form of the natural globular protein with a histidine patch (His-patch-thioredoxin) and is zwitterionic. Histidine 77-86 thioredoxin Homo sapiens 4-15 15697300-6 2005 The thioredoxin is a recombinant form of the natural globular protein with a histidine patch (His-patch-thioredoxin) and is zwitterionic. Histidine 77-86 thioredoxin Homo sapiens 104-115 15697300-6 2005 The thioredoxin is a recombinant form of the natural globular protein with a histidine patch (His-patch-thioredoxin) and is zwitterionic. Histidine 94-97 thioredoxin Homo sapiens 4-15 15697300-6 2005 The thioredoxin is a recombinant form of the natural globular protein with a histidine patch (His-patch-thioredoxin) and is zwitterionic. Histidine 94-97 thioredoxin Homo sapiens 104-115 15667209-10 2005 The nonaged hBChE structure shows one water molecule interacting with Glu197 and the catalytic triad histidine (His438). Histidine 101-110 butyrylcholinesterase Homo sapiens 12-17 15651042-6 2005 By means of DFT (B3LYP, lacv3p**) calculations, we could show that the formation of such a triad is essential to support the proton transfer from selenol to a histidine to stabilise a selenolate anion, which is able to interact with the disulfide of thioredoxin and catalyses the reductive disulfide opening. Histidine 159-168 thioredoxin Homo sapiens 250-261 15661533-4 2005 OVCA1 appears to be the homolog of yeast DPH2, which participates in the first biosynthetic step of diphthamide, by modification of histidine on translation elongation factor 2 (EF-2). Histidine 132-141 2-(3-amino-3-carboxypropyl)histidine synthase Saccharomyces cerevisiae S288C 41-45 15724202-1 2005 The electron transfer reaction of wild-type myoglobin at an electrode was significantly facilitated in a D2O buffer as compared with that in an H2O buffer, with k(0)"(H2O)/k(0)"(D2O)= 0.13, while a minimal deuterium kinetic isotope effect on the myoglobin with modification at distal histidine (His-64) was observed. Histidine 295-298 myoglobin Homo sapiens 44-53 15701055-8 2005 The 14-3-3-binding motif Lys-Lys-Glu-Ser-His-Pro (371-376) was detected in the HvNHX2 amino acid sequence, which is suggestive of possible involvement of the 14-3-3 proteins in the regulation of HvNHX2 function. Histidine 41-44 sodium/proton exchanger Hordeum vulgare 79-85 15701055-8 2005 The 14-3-3-binding motif Lys-Lys-Glu-Ser-His-Pro (371-376) was detected in the HvNHX2 amino acid sequence, which is suggestive of possible involvement of the 14-3-3 proteins in the regulation of HvNHX2 function. Histidine 41-44 sodium/proton exchanger Hordeum vulgare 195-201 15671563-1 2005 PURPOSE: The novel fusion protein, DAB389EGF, composed of the catalytic and translocation domains of diphtheria toxin (DAB389) fused with a His-Ala linker to human epidermal growth factor (EGF) was tested for antiglioma efficacy in an in vivo model of human glioma. Histidine 140-143 epidermal growth factor Homo sapiens 164-187 15671563-1 2005 PURPOSE: The novel fusion protein, DAB389EGF, composed of the catalytic and translocation domains of diphtheria toxin (DAB389) fused with a His-Ala linker to human epidermal growth factor (EGF) was tested for antiglioma efficacy in an in vivo model of human glioma. Histidine 140-143 epidermal growth factor Homo sapiens 41-44 15508143-12 2005 Further sequence analysis revealed total conservation of ATCUN histidines in four proteins including the transcription factor TBX3, implicated in Ulnar-Mammary Syndrome. Histidine 63-73 T-box transcription factor 3 Homo sapiens 126-130 15613086-5 2004 Expressed protein encoded by a carboxy (C)-terminal His-tagged CB2 construct displayed a B(max) value of 9.3 pmol/mg with a K(D) of 7.30 nM using [3(H)]CP-55(940), a standard cannabinoid radioligand, and was selected for subsequent purification experiments. Histidine 52-55 cannabinoid receptor 2 Homo sapiens 63-66 15550245-6 2004 Remarkably, the Fe(II)-heme group in AHSP bound alphaHb is coordinated by the distal but not the proximal histidine. Histidine 106-115 alpha hemoglobin stabilizing protein Homo sapiens 37-41 15476823-2 2004 The site of interaction of the tumor suppressor p53 and the oncoprotein E1A with CBP/p300 has been identified with the third cysteine-histidine-rich (CH3) domain, which incorporates two zinc-binding motifs, ZZ and TAZ2. Histidine 134-143 transformation related protein 53, pseudogene Mus musculus 48-51 15304516-8 2004 Classical pathway regulation, both through decay acceleration and factor I cleavage of C4b, required a cluster of positively charged amino acids in CCP1 stretching into CCP2 (Arg-20, Arg-33, Arg-35, Lys-64, Lys-65, and Lys-88) as well as positively (Lys-131, Lys-133, and His-135) and negatively (Glu-99, Glu-152, and Asp-155) charged areas at opposing faces of the border region between CCPs 2 and 3. Histidine 272-275 coiled-coil domain containing 115 Homo sapiens 148-152 11532454-3 2001 To obtain sufficient amounts of AQP2 for structural analyses, we have expressed recombinant his-tagged human AQP2 (HT-AQP2) in the baculovirus/insect cell system. Histidine 92-95 aquaporin 2 Homo sapiens 32-36 11532454-3 2001 To obtain sufficient amounts of AQP2 for structural analyses, we have expressed recombinant his-tagged human AQP2 (HT-AQP2) in the baculovirus/insect cell system. Histidine 92-95 aquaporin 2 Homo sapiens 109-113 11532454-3 2001 To obtain sufficient amounts of AQP2 for structural analyses, we have expressed recombinant his-tagged human AQP2 (HT-AQP2) in the baculovirus/insect cell system. Histidine 92-95 aquaporin 2 Homo sapiens 115-122 11569620-0 2001 Effects of histidine on working memory deficits induced by the 5-HT1A-receptor agonist 8-OH-DPAT. Histidine 11-20 5-hydroxytryptamine receptor 1A Homo sapiens 63-78 11337504-4 2001 We previously identified His-193 of rat GCS as an important residue in UDP-Glc and GCS inhibitor binding; however, little else is known about the GCS active site. Histidine 25-28 UDP-glucose ceramide glucosyltransferase Rattus norvegicus 40-43 11337504-4 2001 We previously identified His-193 of rat GCS as an important residue in UDP-Glc and GCS inhibitor binding; however, little else is known about the GCS active site. Histidine 25-28 UDP-glucose ceramide glucosyltransferase Rattus norvegicus 83-86 11337504-4 2001 We previously identified His-193 of rat GCS as an important residue in UDP-Glc and GCS inhibitor binding; however, little else is known about the GCS active site. Histidine 25-28 UDP-glucose ceramide glucosyltransferase Rattus norvegicus 83-86 11337504-7 2001 Next, we showed by multiple alignment that the region of GCS flanking His-193 and Cys-207 (amino acids 89-278) contains a D1,D2,D3,(Q/R)XXRW motif found in the putative active site of processive beta-glycosyltransferases (e.g. cellulose, chitin, and hyaluronan synthases). Histidine 70-73 UDP-glucose ceramide glucosyltransferase Rattus norvegicus 57-60 11313341-5 2001 Ascidian acrosin has paired basic residues (Lys(56)-His(57)) in the N-terminal region, which is one of the most characteristic features of mammalian acrosin. Histidine 52-55 acrosin Homo sapiens 9-16 11313341-5 2001 Ascidian acrosin has paired basic residues (Lys(56)-His(57)) in the N-terminal region, which is one of the most characteristic features of mammalian acrosin. Histidine 52-55 acrosin Homo sapiens 149-156 11415453-4 2001 Mutation of the active-site residues Asp(88) or His(118) within the human PP2A catalytic subunit (PP2Ac)alpha impaired catalytic activity in vitro; the D88N and H118N substitutions caused a 9- and 23-fold reduction in specific activity respectively, when compared with wild-type recombinant PP2Ac, indicating an important role for these residues in catalysis. Histidine 48-51 protein phosphatase 2 phosphatase activator Homo sapiens 74-78 11415453-4 2001 Mutation of the active-site residues Asp(88) or His(118) within the human PP2A catalytic subunit (PP2Ac)alpha impaired catalytic activity in vitro; the D88N and H118N substitutions caused a 9- and 23-fold reduction in specific activity respectively, when compared with wild-type recombinant PP2Ac, indicating an important role for these residues in catalysis. Histidine 48-51 protein phosphatase 2 catalytic subunit alpha Homo sapiens 98-103 11396977-3 2001 The soluble cytosolic His(6)-hAR demonstrated similar association and dissociation half-times for mibolerone, similar binding affinity for mibolerone, and similar steroid specificity as bona fide AR. Histidine 22-25 lymphatic vessel endothelial hyaluronan receptor 1 Homo sapiens 29-32 11396977-3 2001 The soluble cytosolic His(6)-hAR demonstrated similar association and dissociation half-times for mibolerone, similar binding affinity for mibolerone, and similar steroid specificity as bona fide AR. Histidine 22-25 lymphatic vessel endothelial hyaluronan receptor 1 Homo sapiens 30-32 11380262-4 2001 As expected, mutation of the P1 arginine to tryptophan, histidine, leucine, and methionine converted the specificity of antithrombin from a trypsin inhibitor (k(assoc) = 2 x 10(5) M(-1) s(-1)) to a chymotrypsin inhibitor (k(assoc) = 10(3)-10(5) M(-1) s(-1)). Histidine 56-65 serpin family C member 1 Homo sapiens 120-132 11278664-7 2001 Mutant ST8Sia II and IV enzymes in which this His residue was changed to Lys showed no detectable enzyme activity, even though they were folded correctly and could bind to CDP-hexanolamine, suggesting the importance of the His residue for their catalytic activity. Histidine 46-49 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 Homo sapiens 7-16 11278664-7 2001 Mutant ST8Sia II and IV enzymes in which this His residue was changed to Lys showed no detectable enzyme activity, even though they were folded correctly and could bind to CDP-hexanolamine, suggesting the importance of the His residue for their catalytic activity. Histidine 223-226 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 Homo sapiens 7-16 11343793-0 2001 The importance of histidine residues in human ecto-nucleoside triphosphate diphosphohydrolase-3 as determined by site-directed mutagenesis. Histidine 18-27 ectonucleoside triphosphate diphosphohydrolase 3 Homo sapiens 46-95 11154690-3 2001 An enzymatic mechanism involving a catalytic metal ion, a Glu/His catalytic dyad, and a charged oxyanion hole was previously proposed based on recently determined FAH crystal structures. Histidine 62-65 fumarylacetoacetate hydrolase Homo sapiens 163-166 11278504-9 2001 All four histidine mutants had k(cat) values 1000-fold lower than wild-type CNP-CF, but K(m) values were similar. Histidine 9-18 2',3'-cyclic nucleotide 3' phosphodiesterase Rattus norvegicus 76-79 11124949-0 2001 Role of two histidines in the (6-4) photolyase reaction. Histidine 12-22 6-4 photolyase Xenopus laevis 31-46 11124949-2 2001 In the active site, which is homologous between the cis,syn-cyclobutane pyrimidine dimer and (6-4) photolyases, four amino acid residues that are specific to (6-4) photolyase, Gln(288), His(354), Leu(355), and His(358), and two conserved tryptophans, Trp(291) and Trp(398), were substituted with alanine. Histidine 186-189 6-4 photolyase Xenopus laevis 94-109 11124949-2 2001 In the active site, which is homologous between the cis,syn-cyclobutane pyrimidine dimer and (6-4) photolyases, four amino acid residues that are specific to (6-4) photolyase, Gln(288), His(354), Leu(355), and His(358), and two conserved tryptophans, Trp(291) and Trp(398), were substituted with alanine. Histidine 210-213 6-4 photolyase Xenopus laevis 94-109 11124949-5 2001 Taking the pH profile of the (6-4) photolyase reaction into consideration with this observation, we propose a mechanism in which these histidines catalyze the formation of the four-membered ring intermediate in the repair process of this enzyme. Histidine 135-145 6-4 photolyase Xenopus laevis 30-45 11238646-7 2001 Mutational analysis of residues participating in the formation of this pocket demonstrates that Asp(112) and Tyr(175) are important contact residues for C1q binding, that Glu(88) influences the conformational change in C1q necessary for complement activation, and that Asn(158) and His(38) probably contribute to the correct geometry of the binding site. Histidine 282-285 complement C1q A chain Homo sapiens 153-156 11238646-7 2001 Mutational analysis of residues participating in the formation of this pocket demonstrates that Asp(112) and Tyr(175) are important contact residues for C1q binding, that Glu(88) influences the conformational change in C1q necessary for complement activation, and that Asn(158) and His(38) probably contribute to the correct geometry of the binding site. Histidine 282-285 complement C1q A chain Homo sapiens 219-222 11080498-10 2001 The reverse substitution of Ser by His in PMA2 resulted in the failure of this enzyme to complement the absence of yeast H(+)-ATPases. Histidine 35-38 H(+)-exporting P2-type ATPase PMA2 Saccharomyces cerevisiae S288C 42-46 11237694-1 2001 We succeeded in the expression, purification, and refolding of the immunoglobulin-like (Ig) domain of human granulocyte-colony-stimulating factor (G-CSF) receptor with amino-terminal His-tag in Escherichia coli. Histidine 183-186 colony stimulating factor 3 receptor Homo sapiens 108-162 11237694-3 2001 The eluted His-Ig/G-CSF complex could be separated from excess G-CSF by Ni-NTA column chromatography. Histidine 11-14 colony stimulating factor 3 Homo sapiens 18-23 11237694-3 2001 The eluted His-Ig/G-CSF complex could be separated from excess G-CSF by Ni-NTA column chromatography. Histidine 11-14 colony stimulating factor 3 Homo sapiens 63-68 11237699-1 2001 A histidine-tagged, carboxy-terminal fragment of the murine double minute 2 gene product, p90(MDM2), was purified by Ni--NTA chromatography and preparative gel electrophoresis. Histidine 2-11 transformed mouse 3T3 cell double minute 2 Mus musculus 94-98 11115608-4 2001 NS1 bound to the two related cysteine-histidine-rich regions of CBP, referred to as C/H1 and C/H3, the former of which has an antagonistic function to CBP upon the NS1-transactivation. Histidine 38-47 SUN domain containing ossification factor Homo sapiens 84-97 11095676-3 2000 Bas1p is a Myb-related transcription factor that acts together with the homeodomain-related Bas2p (Pho2p) to regulate purine and histidine biosynthesis genes in response to extracellular purine limitation. Histidine 129-138 Pho2p Saccharomyces cerevisiae S288C 92-97 11095676-3 2000 Bas1p is a Myb-related transcription factor that acts together with the homeodomain-related Bas2p (Pho2p) to regulate purine and histidine biosynthesis genes in response to extracellular purine limitation. Histidine 129-138 Pho2p Saccharomyces cerevisiae S288C 99-104 11060015-1 2000 The solution structure of the second protein-protein complex of the Escherichia coli phosphoenolpyruvate: sugar phosphotransferase system, that between histidine-containing phosphocarrier protein (HPr) and glucose-specific enzyme IIA(Glucose) (IIA(Glc)), has been determined by NMR spectroscopy, including the use of dipolar couplings to provide long-range orientational information and newly developed rigid body minimization and constrained/restrained simulated annealing methods. Histidine 152-161 colicin Ia immunity protein Escherichia coli 230-252 11089639-11 2000 The model predicted a pattern of interactions between amino acids and DNA bases which reflect for ARNT what is experimentally observed among different X-ray structures of other bHLH transcription factors possessing the H (His), E (Glu), R (Arg) triad, as ARNT does. Histidine 222-225 aryl hydrocarbon receptor nuclear translocator Homo sapiens 98-102 11089639-11 2000 The model predicted a pattern of interactions between amino acids and DNA bases which reflect for ARNT what is experimentally observed among different X-ray structures of other bHLH transcription factors possessing the H (His), E (Glu), R (Arg) triad, as ARNT does. Histidine 222-225 aryl hydrocarbon receptor nuclear translocator Homo sapiens 255-259 10972987-3 2000 NP/NMP4 are nuclear matrix proteins that contain from five to eight Cys(2)His(2) zinc fingers. Histidine 74-77 zinc finger protein 384 Rattus norvegicus 3-7 10823841-5 2000 Interestingly the mutation in STAT5A-N642H resulted in restoration of the conserved critical histidine which is involved in the binding of phosphotyrosine in the majority of SH2-containing proteins. Histidine 93-102 signal transducer and activator of transcription 5A Mus musculus 30-36 10964987-14 2000 In contrast, the N-terminal histidine-tagged fusion protein bound IL3 receptor with a 10-fold lower affinity and was 10-fold less cytotoxic to IL3 receptor positive blasts. Histidine 28-37 interleukin 3 Homo sapiens 66-69 10964987-14 2000 In contrast, the N-terminal histidine-tagged fusion protein bound IL3 receptor with a 10-fold lower affinity and was 10-fold less cytotoxic to IL3 receptor positive blasts. Histidine 28-37 interleukin 3 Homo sapiens 143-146 10821667-1 2000 Cytochrome b(5) (cyt b(5)) holds heme using two axial histidines, His63 and His39, that are located in the centers of the two heme-binding loops. Histidine 54-64 cytochrome b5 type A Homo sapiens 0-15 10821667-1 2000 Cytochrome b(5) (cyt b(5)) holds heme using two axial histidines, His63 and His39, that are located in the centers of the two heme-binding loops. Histidine 54-64 cytochrome b5 type A Homo sapiens 17-25 10700443-3 2000 We prospectively studied the association of the histidine (H)(72)-->tyrosine (Y) mutation in p22(phox) with the severity and progression/regression of coronary artery disease (CAD), plasma lipid levels, clinical events, and response to treatment with fluvastatin in a well-characterized population. Histidine 48-57 calcineurin like EF-hand protein 1 Homo sapiens 96-99 10803111-4 2000 A widespread histidine/tyrosine polymorphism was detected in codon 17 of S100A4. Histidine 13-22 S100 calcium binding protein A4 Canis lupus familiaris 73-79 10684599-13 2000 In particular, CDR1 provides a strong interaction to the hapten through two histidine residues bound to its copper atoms. Histidine 76-85 cerebellar degeneration related protein 1 Homo sapiens 15-19 10672011-8 2000 Analysis of CD spectra suggests an overall fold similar to that of the CCHH fingers, and indeed a point mutant of FOG-F1 in which the final cysteine residue is replaced by histidine remains capable of folding. Histidine 172-181 folded gastrulation Drosophila melanogaster 114-117 10703921-6 2000 Treatment with a synthetic peptide containing the His-Ala-Val (HAV) adhesion motif of N-cadherin significantly decreased bone nodule formation in primary cultures of fetal rat calvaria and inhibited cell-to-cell contact in rat osteoblastic TRAB-11 cells. Histidine 50-53 cadherin 2 Rattus norvegicus 86-96 10627551-9 2000 In addition, PrP(Sc) with the codon 171 (Gln-to-His) polymorphism is the first variant reported to induce higher conversion efficiencies with heterologous rather than homologous PrP variants. Histidine 48-51 major prion protein Ovis aries 13-16 10627551-9 2000 In addition, PrP(Sc) with the codon 171 (Gln-to-His) polymorphism is the first variant reported to induce higher conversion efficiencies with heterologous rather than homologous PrP variants. Histidine 48-51 major prion protein Ovis aries 178-181 10676874-0 2000 A critical histidine in the vesicular acetylcholine transporter. Histidine 11-20 solute carrier family 18 member A3 Homo sapiens 28-63 10667598-6 2000 However, we also discovered that a subset of TTD cells, in which arg112 in the NH2-terminal region of the XPD protein is mutated to histidine, had an ICAM-1 response similar to that of XP-D cells. Histidine 132-141 ERCC excision repair 2, TFIIH core complex helicase subunit Homo sapiens 106-109 11087097-1 2000 We developed a rabbit polyclonal antiserum reactive against a recombinant 6x His-UL46 fusion protein expressed in Escherichia coli, and using this antiserum identified the UL46 gene product of herpes simplex virus type 2 (HSV-2) to be phosphoproteins with apparent molecular masses of 82-, 84-, and 86-kDa in infected Vero cells. Histidine 77-80 modulates transactivating tegument protein VP16 Human alphaherpesvirus 2 81-85 11087097-1 2000 We developed a rabbit polyclonal antiserum reactive against a recombinant 6x His-UL46 fusion protein expressed in Escherichia coli, and using this antiserum identified the UL46 gene product of herpes simplex virus type 2 (HSV-2) to be phosphoproteins with apparent molecular masses of 82-, 84-, and 86-kDa in infected Vero cells. Histidine 77-80 modulates transactivating tegument protein VP16 Human alphaherpesvirus 2 172-176 10601301-5 1999 The Delta-5 desaturase contains two membrane-spanning domains, three histidine-rich regions, and a cytochrome b(5) domain that all align perfectly with the same domains located in the Delta-6 desaturase. Histidine 69-78 fatty acid desaturase 1 Homo sapiens 4-22 10585483-4 1999 ArcB is a tripartite kinase, possessing a primary transmitter, a receiver, and a secondary transmitter domain that catalyzes the phosphorylation of ArcA via a His --> Asp --> His --> Asp phosphorelay, as well as the dephosphorylation of ArcA-P by a reverse phosphorelay. Histidine 181-184 hypothetical protein Escherichia coli 0-4 10648963-8 1999 The cloned Ra-eRF1 gene complemented a temperature-sensitive allele in the eRF1 gene, sup45 (ts), of S. cerevisiae, though the complementation activity was significantly impaired by the histidine tag, whereas Tt-eRF1 failed to complement the sup45 (ts) allele. Histidine 186-195 translation termination factor eRF1 Saccharomyces cerevisiae S288C 86-91 10531481-0 1999 Refined structure of the histidine-containing phosphotransfer (HPt) domain of the anaerobic sensor kinase ArcB from Escherichia coli at 1.57 A resolution. Histidine 25-34 hypothetical protein Escherichia coli 106-110 10531481-1 1999 The crystal structure of the histidine-containing phosphotransfer (HPt) domain of the anaerobic sensor kinase ArcB from Escherichia coli has been refined to 1.57 A resolution, using the coordinates of the earlier 2.06 A structure as a starting model. Histidine 29-38 hypothetical protein Escherichia coli 110-114 10531349-7 1999 These interactions probably involve sulfate groups in the glycosaminoglycans and positively charged histidine residues in GM-CSF. Histidine 100-109 colony stimulating factor 2 Homo sapiens 122-128 10510301-12 1999 The pH-dependence of the midpoint transition temperature of endotherms indicated that the high difference in stabilization energy between aged and native BuChE (DeltaDeltaG=23.7 kJ/mol at pH 8.0) is mainly due to the salt bridge between protonated His-438 and PO(-), with pK(His-438)=8.3. Histidine 248-251 butyrylcholinesterase Homo sapiens 154-159 10510301-12 1999 The pH-dependence of the midpoint transition temperature of endotherms indicated that the high difference in stabilization energy between aged and native BuChE (DeltaDeltaG=23.7 kJ/mol at pH 8.0) is mainly due to the salt bridge between protonated His-438 and PO(-), with pK(His-438)=8.3. Histidine 275-278 butyrylcholinesterase Homo sapiens 154-159 10504448-7 1999 In addition two novel mutations within the helix initiation motif of hHb6 were found in Scottish and Portuguese cases, in whom the same highly conserved asparagine residue N114 was mutated to histidine (N114H) or aspartic acid (N114D) residues, respectively. Histidine 192-201 keratin 86 Homo sapiens 69-73 10517800-14 1999 Systematic mutation of extracellular histidine residues in the GlyR alpha1 subunit revealed that mutations H107A or H109A completely abolished inhibition of glycine-gated currents by Zn2+. Histidine 37-46 glycine receptor alpha 1 Homo sapiens 63-74 10517800-18 1999 An examination of Zn2+ co-ordination in metalloenzymes revealed that the histidine- hydrophobic residue-histidine motif found to be responsible for binding Zn2+ in the human GlyR alpha1 subunit is also shared by some of these enzymes. Histidine 73-82 glycine receptor alpha 1 Homo sapiens 174-185 10517800-18 1999 An examination of Zn2+ co-ordination in metalloenzymes revealed that the histidine- hydrophobic residue-histidine motif found to be responsible for binding Zn2+ in the human GlyR alpha1 subunit is also shared by some of these enzymes. Histidine 104-113 glycine receptor alpha 1 Homo sapiens 174-185 10490616-4 1999 ERF2 encodes a 41-kDa protein with four predicted transmembrane (TM) segments and a motif consisting of the amino acids Asp-His-His-Cys (DHHC) within a cysteine-rich domain (CRD), called DHHC-CRD. Histidine 124-127 palmitoyltransferase ERF2 Saccharomyces cerevisiae S288C 0-4 10570924-4 1999 This observation suggests a novel role in proteolysis for residues of DPP IV distant from the Ser-Asp-His catalytic triad. Histidine 102-105 dipeptidyl peptidase 4 Homo sapiens 70-76 10493588-1 1999 The extracellular portions of the chains that comprise the human type I interferon receptor, IFNAR1 and IFNAR2, have been expressed and purified as recombinant soluble His-tagged proteins, and their interactions with each other and with human interferon-beta-1a (IFN-beta-1a) were studied by gel filtration and by cross-linking. Histidine 168-171 interferon alpha and beta receptor subunit 1 Homo sapiens 93-99 10446221-2 1999 Several missense IGF2R mutations have been identified in human cancers, including the following amino acid substitutions occurring in the extracytoplasmic domain of the receptor: Cys-1262 --> Ser, Gln-1445 --> His, Gly-1449 --> Val, Gly-1464 --> Glu, and Ile-1572 --> Thr. Histidine 216-219 insulin like growth factor 2 receptor Homo sapiens 17-22 10446428-4 1999 GPAT was expressed in Sf21 insect cells, and specific inhibitors strongly suggest that, like the Escherichia coli GPAT, the recombinant mitochondrial GPAT and the mitochondrial GPAT isoform in rat liver contain critical serine, histidine, and arginine residues. Histidine 228-237 glycerol-3-phosphate acyltransferase, mitochondrial Mus musculus 0-4 10446428-4 1999 GPAT was expressed in Sf21 insect cells, and specific inhibitors strongly suggest that, like the Escherichia coli GPAT, the recombinant mitochondrial GPAT and the mitochondrial GPAT isoform in rat liver contain critical serine, histidine, and arginine residues. Histidine 228-237 glycerol-3-phosphate acyltransferase, mitochondrial Mus musculus 114-118 10446428-4 1999 GPAT was expressed in Sf21 insect cells, and specific inhibitors strongly suggest that, like the Escherichia coli GPAT, the recombinant mitochondrial GPAT and the mitochondrial GPAT isoform in rat liver contain critical serine, histidine, and arginine residues. Histidine 228-237 glycerol-3-phosphate acyltransferase, mitochondrial Mus musculus 114-118 10446428-4 1999 GPAT was expressed in Sf21 insect cells, and specific inhibitors strongly suggest that, like the Escherichia coli GPAT, the recombinant mitochondrial GPAT and the mitochondrial GPAT isoform in rat liver contain critical serine, histidine, and arginine residues. Histidine 228-237 glycerol-3-phosphate acyltransferase, mitochondrial Mus musculus 114-118 10438744-5 1999 Deletion of the high-affinity histidine permease Hip1p in His(-) strains resulted in even greater sensitivity to Cu, Co, and Ni and the requirement of an even higher level of histidine to reverse the inhibition. Histidine 30-39 histidine permease Saccharomyces cerevisiae S288C 49-54 10391916-12 1999 LAT-2 exhibits higher affinity (Km = 30-50 microM) to Tyr, Phe, Trp, Thr, Asn, Ile, Cys, Ser, Leu, Val, and Gln and relatively lower affinity (Km = 180-300 microM) to His, Ala, Met, and Gly. Histidine 167-170 solute carrier family 7 member 8 Rattus norvegicus 0-5 10381378-9 1999 When a conserved histidine within the human SIRT2 sirtuin was converted to a tyrosine, the mutant recombinant protein was unable to transfer radioactivity from [32P]NAD to BSA. Histidine 17-26 sirtuin 2 Homo sapiens 44-49 10329785-5 1999 Ferrochelatase from Drosophila melanogaster has been expressed in Escherichia coli with an amino-terminal six-histidine tag and purified to homogeneity. Histidine 110-119 Ferrochelatase Drosophila melanogaster 0-14 10347122-7 1999 Western Blot with an HNE-Histidine antibody showed enhanced formation of HNE adducts with COX from ethanol-exposed rats, which was more pronounced in fetal than in adult livers. Histidine 25-34 coproporphyrinogen oxidase Rattus norvegicus 90-93 10397171-5 1999 The entire coding region of p40phox was shown to interact with TRX both in assays of histidine prototrophy and beta-galactosidase activity; in contrast, no interaction was observed with substituted mutant TRX (C32S/C35S), which lacks reducing activity. Histidine 85-94 neutrophil cytosolic factor 4 Homo sapiens 28-35 10397171-5 1999 The entire coding region of p40phox was shown to interact with TRX both in assays of histidine prototrophy and beta-galactosidase activity; in contrast, no interaction was observed with substituted mutant TRX (C32S/C35S), which lacks reducing activity. Histidine 85-94 thioredoxin Homo sapiens 63-66 10350163-0 1999 Histamine H3 receptor binding sites in rat cortex following L-histidine loading. Histidine 60-71 histamine receptor H3 Rattus norvegicus 0-21 10085111-12 1999 Histidine residues at positions 46 and 60 are responsible for heme ligation because the H46N- or H60N-substituted QPs3 fail to restore cytochrome b560 upon addition of hemin chloride. Histidine 0-9 succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial Bos taurus 114-118 10051442-6 1999 MET8 was further cloned into pET14b to allow expression of the protein with an N-terminal His-tag. Histidine 90-93 bifunctional precorrin-2 dehydrogenase/sirohydrochlorin ferrochelatase MET8 Saccharomyces cerevisiae S288C 0-4 10087200-6 1999 When the presumptive active site histidine was altered to alanine by site-directed mutagenesis, enzyme activity was abolished, confirming the classification of (MMU)Minpp1 as a histidine phosphatase. Histidine 33-42 multiple inositol-polyphosphate phosphatase 1 Homo sapiens 165-171 10037691-4 1999 IIABMan transfers phosphoryl groups from the phospho-histidine-containing phospho-carrier protein of the PTS to His-10 on IIA, hence to His-175 on IIB, and finally to the 6"-OH of the transported hexose. Histidine 53-62 colicin Ia immunity protein Escherichia coli 0-3 10037691-4 1999 IIABMan transfers phosphoryl groups from the phospho-histidine-containing phospho-carrier protein of the PTS to His-10 on IIA, hence to His-175 on IIB, and finally to the 6"-OH of the transported hexose. Histidine 112-115 colicin Ia immunity protein Escherichia coli 0-3 10037691-4 1999 IIABMan transfers phosphoryl groups from the phospho-histidine-containing phospho-carrier protein of the PTS to His-10 on IIA, hence to His-175 on IIB, and finally to the 6"-OH of the transported hexose. Histidine 136-139 colicin Ia immunity protein Escherichia coli 0-3 10205296-3 1999 The bond between Fe and proximal His-F8 allows additional integration of the structures of the heme cavity and the myoglobin molecule as a whole, providing its functional activity and highly cooperative conformational transitions. Histidine 34-37 myoglobin Homo sapiens 116-125 10081961-3 1999 While a hydrophobic residue is found at position 21 in most of the KH modules, a buried His is conserved in all the 15 KH repeats of vigilin. Histidine 88-91 high density lipoprotein binding protein Homo sapiens 133-140 10081961-6 1999 ii) can we define the interactions that allow a conserved buried position to be occupied by a histidine both in vig-KH6 and in the whole vigilin KH sub-family? Histidine 94-103 high density lipoprotein binding protein Homo sapiens 137-144 10499107-5 1999 The Fe-C and C-O vibrational frequencies of CO-myoglobin have also been studied and the results indicate that CO forms hydrogen bonds to either the distal histidine residue or a water molecule during normal conditions. Histidine 155-164 myoglobin Homo sapiens 47-56 9973256-3 1999 We show that CREB binding protein (CBP), through two cysteine-histidine rich domains (C/H1 and C/H3), specifically and constitutively interacts with Pit-1 in pituitary cells. Histidine 62-71 SUN domain containing ossification factor Homo sapiens 86-99 9890932-0 1999 Effect of pH on formation of a nativelike intermediate on the unfolding pathway of a Lys 73 --> His variant of yeast iso-1-cytochrome c. Previous work on a Lys 73 --> His (H73) variant of iso-1-cytochrome c at pH 7.5 [Godbole et al. Histidine 99-102 threonine ammonia-lyase ILV1 Saccharomyces cerevisiae S288C 120-125 10027556-4 1999 As a result of screening, we identified two proteins (192 and 180 kDa), which specifically bound to His-dPER/PAS in rat brain extracts. Histidine 100-103 period Drosophila melanogaster 104-108 10089421-2 1999 Recent biochemical studies have shown that SixA is involved in the signal transduction of the His-Asp phosphorelay through the dephosphorylation of the histidine-containing phosphotransfer (HPt) domain of the anaerobic sensor kinase ArcB. Histidine 94-97 hypothetical protein Escherichia coli 233-237 10089421-2 1999 Recent biochemical studies have shown that SixA is involved in the signal transduction of the His-Asp phosphorelay through the dephosphorylation of the histidine-containing phosphotransfer (HPt) domain of the anaerobic sensor kinase ArcB. Histidine 152-161 hypothetical protein Escherichia coli 233-237 10025663-0 1999 Receptor recognition by histidine 16 of human epidermal growth factor via hydrogen-bond donor/acceptor interactions. Histidine 24-33 epidermal growth factor Homo sapiens 46-69 10780478-3 1999 Here, we found that other mature tRNAs of Drosophila were also hyperprocessed by M1 RNA in vitro and that some of such tRNAs were probably alanine and histidine tRNAs. Histidine 151-160 transfer RNA:Serine-AGA 3-1 Drosophila melanogaster 33-38 10780478-3 1999 Here, we found that other mature tRNAs of Drosophila were also hyperprocessed by M1 RNA in vitro and that some of such tRNAs were probably alanine and histidine tRNAs. Histidine 151-160 transfer RNA:Serine-AGA 3-1 Drosophila melanogaster 119-124 10780478-3 1999 Here, we found that other mature tRNAs of Drosophila were also hyperprocessed by M1 RNA in vitro and that some of such tRNAs were probably alanine and histidine tRNAs. Histidine 151-160 transfer RNA:Serine-AGA 3-1 Drosophila melanogaster 119-124 10447101-2 1999 Replacement of His with Ala resulted in [Ala6]-MT-II with affinity and agonist potency at human MC3, MC4, and MC5 receptors similar to MT-II. Histidine 15-18 metallothionein 2A Homo sapiens 47-52 9830034-2 1998 Under those conditions, the tripartite sensor kinase ArcB undergoes autophosphorylation at the expense of ATP and subsequently transphosphorylates its cognate response regulator ArcA through a His --> Asp --> His --> Asp phosphorelay pathway. Histidine 193-196 hypothetical protein Escherichia coli 53-57 9830034-2 1998 Under those conditions, the tripartite sensor kinase ArcB undergoes autophosphorylation at the expense of ATP and subsequently transphosphorylates its cognate response regulator ArcA through a His --> Asp --> His --> Asp phosphorelay pathway. Histidine 215-218 hypothetical protein Escherichia coli 53-57 9830034-5 1998 This reverse phosphorelay involves both the conserved His-717 of the secondary transmitter domain and the conserved Asp-576 of the receiver domain of ArcB but not the conserved His-292 of its primary transmitter domain. Histidine 54-57 hypothetical protein Escherichia coli 150-154 9832609-5 1998 However, if the cDNA was fused with the histidine-tag sequence at the N-terminus, MTFmt could be expressed in Escherichia coli. Histidine 40-49 mitochondrial methionyl-tRNA formyltransferase Homo sapiens 82-87 9832609-9 1998 The purified recombinant MTFmt with the histidine-tag showed almost identical kinetic parameters to those of native MTFmt. Histidine 40-49 mitochondrial methionyl-tRNA formyltransferase Homo sapiens 25-30 9806842-2 1998 The product, which consists of 785 amino acids with a deduced molecular mass of 88.2 kDa, possesses His and Cys domains that are highly conserved in all members of the ubiquitin-specific processing (UBP) family of proteases. Histidine 100-103 ubiquitin specific peptidase 1 Homo sapiens 168-197 9806842-2 1998 The product, which consists of 785 amino acids with a deduced molecular mass of 88.2 kDa, possesses His and Cys domains that are highly conserved in all members of the ubiquitin-specific processing (UBP) family of proteases. Histidine 100-103 ubiquitin specific peptidase 1 Homo sapiens 199-202 9972245-0 1998 Mutational analysis of the histidine-containing phosphotransfer (HPt) signaling domain of the ArcB sensor in Escherichia coli. Histidine 27-36 hypothetical protein Escherichia coli 94-98 9730818-8 1998 These results show that NO binding to sGC not only leads to the cleavage of the Fe-His bond but also induces a conformational change which opens the heme proximal pocket large enough to accommodate an exogenous imidazole molecule. Histidine 83-86 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 38-41 9741684-4 1998 Recombinant, purified histidine-tagged protein exhibited the enzymatic properties associated with GGPP synthase, namely the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. Histidine 22-31 geranylgeranyl diphosphate synthase 1 Homo sapiens 98-111 9768847-4 1998 The bound Cd2+ ions form a bridge between the introduced cysteine in one channel subunit and a native histidine in another subunit, and the bridge traps the gate in the open state. Histidine 102-111 CD2 molecule Homo sapiens 10-13 9724720-6 1998 The inverse combination (C-1/G73) leads to the worst histidine acceptors with charging efficiencies reduced by 2-3 orders of magnitude. Histidine 53-62 heterogeneous nuclear ribonucleoprotein C Homo sapiens 25-32 9724722-3 1998 The human endostatin zinc site is formed by three histidines at the N terminus, residues 1, 3, and, 11, and an aspartic acid at residue 76. Histidine 50-60 collagen type XVIII alpha 1 chain Homo sapiens 10-20 9807817-5 1998 The interaction between AtFKBP12 and AtFIP37 in the 2-hybrid system, as assessed by histidine auxotrophy and beta-galactosidase activity, was disrupted by FK506, but not by cyclosporin A, a drug that binds to cyclophilin A. Histidine 84-93 FK506-binding protein 12 Arabidopsis thaliana 24-32 9685739-0 1998 The structure and function of the histidine-containing phosphotransfer (HPt) signaling domain of the Escherichia coli ArcB sensor. Histidine 34-43 hypothetical protein Escherichia coli 118-122 9685739-2 1998 ArcB is an unorthodox His-kinase, in that it contains three types of phosphotransfer signaling domains in its primary amino acid sequence, namely, transmitter (or His-kinase), receiver, and histidine-containing phosphotransfer (HPt) domains. Histidine 190-199 hypothetical protein Escherichia coli 0-4 9765616-6 1998 Only one Fe-NTA-induced RCC of grade 1 revealed missense mutations with loss of heterozygosity in exon 10 of the Tsc2 gene (codons 334, GTG (Val) to GCG (Ala), and 336, TAT (Tyr) to CAT (His). Histidine 187-190 TSC complex subunit 2 Rattus norvegicus 113-117 9749675-7 1998 In addition, when His-90 in IIA(Glc) was replaced by glutamine, both phosphorylation of IIA(Glc) and the overproduction of cAMP in crp cells were eliminated. Histidine 18-21 colicin Ia immunity protein Escherichia coli 28-31 9749675-7 1998 In addition, when His-90 in IIA(Glc) was replaced by glutamine, both phosphorylation of IIA(Glc) and the overproduction of cAMP in crp cells were eliminated. Histidine 18-21 colicin Ia immunity protein Escherichia coli 88-91 9742571-4 1998 Molecular analysis of the affected son revealed a G to A mutation in codon 156 of keratin 10, resulting in an arginine to histidine substitution within the highly conserved 1A region. Histidine 122-131 keratin 10 Homo sapiens 82-92 9632755-4 1998 Affinity isolation of histidine-tagged Sba1p (Sba1(His6)) after expression in yeast led to coisolation of Hsp90 and the cyclophilin homolog Cpr6. Histidine 22-31 Hsp90 family chaperone HSP82 Saccharomyces cerevisiae S288C 106-111 9671411-6 1998 The PML aminoterminal portion retained within the PML/RARalpha protein contains the RING finger, two newly defined cystein/histidine-rich motifs called B-boxes (B1 and B2) and a coiled-coil region. Histidine 123-132 PML nuclear body scaffold Homo sapiens 4-7 9671411-6 1998 The PML aminoterminal portion retained within the PML/RARalpha protein contains the RING finger, two newly defined cystein/histidine-rich motifs called B-boxes (B1 and B2) and a coiled-coil region. Histidine 123-132 PML nuclear body scaffold Homo sapiens 50-53 9671411-6 1998 The PML aminoterminal portion retained within the PML/RARalpha protein contains the RING finger, two newly defined cystein/histidine-rich motifs called B-boxes (B1 and B2) and a coiled-coil region. Histidine 123-132 retinoic acid receptor alpha Homo sapiens 54-62 9601054-6 1998 It was found that the mutation of Lys83, Arg347 and Arg358 produced proteins that were deficient in their responsiveness to cytochrome b5, and the effect was most pronounced for the two arginine mutants (Arg347-->His and Arg358-->Gln) which have been found in male patients suffering from genital ambiguity. Histidine 216-219 cytochrome b5 type A Homo sapiens 124-137 9582326-10 1998 In contrast, complex p38.p37.p36-his displayed no ATPase, suggesting that p40 is essential for ATPase activity. Histidine 33-36 annexin A2 Homo sapiens 29-32 9582326-12 1998 p36 complex was more salt-resistant than that of the p40-his.p37.p36 complex. Histidine 57-60 annexin A2 Homo sapiens 65-68 9553063-11 1998 Depletion of histidine-tagged CRK3 from L. mexicana cell extracts, by Ni-nitrilotriacetic acid agarose selection, reduced histone H1 kinase activity binding to p13(suc1). Histidine 13-22 H3 histone pseudogene 6 Homo sapiens 160-163 9553063-13 1998 SBCRK and histidine-tagged CRK3 activities were inhibited by the purine analogue olomoucine with an IC50 of 28 and 42 microM, respectively, 5-6-fold higher than human p34(cdc2)/cyclinB. Histidine 10-19 cyclin dependent kinase 1 Homo sapiens 171-175 9512488-0 1998 Mutational analysis of histidine residues in the rabbit Na+/dicarboxylate co-transporter NaDC-1. Histidine 23-32 solute carrier family 13 member 2 Oryctolagus cuniculus 89-95 9512488-2 1998 Therefore the role of histidine residues in the function of NaDC-1 was examined by site-directed mutagenesis. Histidine 22-31 solute carrier family 13 member 2 Oryctolagus cuniculus 60-66 9512488-3 1998 All 11 histidine residues in NaDC-1 were converted to alanine, but only mutant H106A exhibited a decrease in succinate transport. Histidine 7-16 solute carrier family 13 member 2 Oryctolagus cuniculus 29-35 9512488-4 1998 Additional mutations of NaDC-1 at position 106 showed that aspartic acid and asparagine, but not arginine, can substitute for histidine. Histidine 126-135 solute carrier family 13 member 2 Oryctolagus cuniculus 24-30 9528793-5 1998 The transactivation function of Ets-1 correlated with its ability to bind an N-terminal cysteine- and histidine-rich region spanning CBP residues 313 to 452. Histidine 102-111 ETS proto-oncogene 1, transcription factor Homo sapiens 32-37 9528793-6 1998 Ets-1 also bound a second cysteine- and histidine-rich region of CBP, between residues 1449 and 1892. Histidine 40-49 ETS proto-oncogene 1, transcription factor Homo sapiens 0-5 9521770-3 1998 There are four conserved histidine residues in the heme binding region of sGC. Histidine 25-34 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 74-77 9521770-5 1998 Site-directed mutagenesis was used to individually change each of the conserved histidines in sGC beta1(1-385) to alanine or glycine, and the resulting mutants were expressed in E. coli. Histidine 80-90 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 94-97 9482873-4 1998 Comparison of the GliPR model with the P14a structure lead to the identification of a common partially solvent-exposed spatial cluster of four amino acid residues, His-69, Glu-88, Glu-110, and His-127 in the GliPR numeration. Histidine 164-167 pathogenesis-related leaf protein 6 Solanum lycopersicum 39-43 9482873-4 1998 Comparison of the GliPR model with the P14a structure lead to the identification of a common partially solvent-exposed spatial cluster of four amino acid residues, His-69, Glu-88, Glu-110, and His-127 in the GliPR numeration. Histidine 193-196 pathogenesis-related leaf protein 6 Solanum lycopersicum 39-43 9502416-8 1998 Amino-terminal sequence analysis of the protein revealed a Gly-Pro-Ala-Lys-Ser-Pro-Tyr-Gln-Leu-Val-Leu-Gln-His-Ser-Arg sequence indistinguishable from an amino-terminal protein sequence deduced from a cDNA clone designated beta ig-h3, and it as well as the abnormal accumulations in GCD cross-reacted with beta ig-h3 antiserum. Histidine 107-110 guanylate cyclase 2E, pseudogene Homo sapiens 283-286 9473505-4 1998 A mutant strain of S. cerevisiae that is both a histidine auxotroph and a hip1 deletion mutant is unable to grow on low histidine media. Histidine 120-129 histidine permease Saccharomyces cerevisiae S288C 74-78 9473505-9 1998 In a hip1 tat1 double mutant, the level of histidine required for growth increased eight-fold in comparison to the hip1 single mutant. Histidine 43-52 histidine permease Saccharomyces cerevisiae S288C 5-9 9473505-9 1998 In a hip1 tat1 double mutant, the level of histidine required for growth increased eight-fold in comparison to the hip1 single mutant. Histidine 43-52 histidine permease Saccharomyces cerevisiae S288C 115-119 9457881-2 1998 To elucidate the specific role of IIA(Glc) phosphorylation in the regulation of adenylyl cyclase activity, both the phosphorylatable histidine (H90) and the interactive histidine (H75) of IIA(Glc) were mutated by site-directed mutagenesis to glutamine and glutamate. Histidine 133-142 colicin Ia immunity protein Escherichia coli 34-37 9447964-2 1998 CPEB, which is conserved from mammals to invertebrates, is composed of three regions: an amino-terminal portion with no obvious functional motif, two RNA recognition motifs (RRMs), and a cysteine-histidine region that is reminiscent of a zinc finger. Histidine 196-205 cytoplasmic polyadenylation element binding protein 1 L homeolog Xenopus laevis 0-4 9425044-2 1998 By placing a His near the oxyanion hole of human butyrylcholinesterase (BChE), we made an esterase (G117H) that catalyzed the hydrolysis of several OP, including sarin and VX [Millard et al. Histidine 13-16 butyrylcholinesterase Homo sapiens 49-70 9425044-2 1998 By placing a His near the oxyanion hole of human butyrylcholinesterase (BChE), we made an esterase (G117H) that catalyzed the hydrolysis of several OP, including sarin and VX [Millard et al. Histidine 13-16 butyrylcholinesterase Homo sapiens 72-76 9782258-5 1998 We used a baculovirus expression system to produce soluble recombinant murine Bgp receptors in which the transmembrane and cytoplasmic domains have been replaced with a six-histidine tag. Histidine 173-182 carcinoembryonic antigen-related cell adhesion molecule 1 Mus musculus 78-81 9438388-4 1998 A soluble VEGF receptor was constructed by fusing the entire extracellular domain of murine flk-1 to a six-histidine tag at the COOH terminus (ExFlk.6His). Histidine 107-116 vascular endothelial growth factor A Rattus norvegicus 10-14 9450689-0 1997 An active-site histidine of NR1/2C mediates voltage-independent inhibition by zinc. Histidine 15-24 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 28-31 9450689-6 1997 Reduction of zinc inhibition of NR1/2C heteromers was seen after labeling with the histidine-modifying reagent diethylpyrocarbonate. Histidine 83-92 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 32-35 9450689-7 1997 This finding suggests that the NR1/2C heteromeric ion channel contains an active-site histidine responsible for zinc inhibition. Histidine 86-95 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 31-34 9436819-4 1997 Two weeks after angioplasty, vascular ACE activity of the angioplasty subgroup was significantly higher than that of the nonangioplasty subgroup (from 0.44 to 1.19 nmol His-Leu/mg/min; p < 0.01). Histidine 169-172 angiotensin-converting enzyme Oryctolagus cuniculus 38-41 9414554-5 1997 Analysis of the tryptic digestion products of the iodoacetate-modified S-RNase by reversed-phase high-performance liquid chromatography and electrospray-ionization mass spectrometry showed that histidine-32 was preferentially modified in the absence of 3"-GMP. Histidine 194-203 GDP-mannose pyrophosphorylase Solanum lycopersicum 256-259 9359858-1 1997 Met-157 in the active site of human glyoxalase I was changed by site-directed mutagenesis into alanine, glutamine or histidine in order to evaluate its possible role in catalysis. Histidine 117-126 glyoxalase I Homo sapiens 36-48 9376358-0 1997 Identification of the predominant non-native histidine ligand in unfolded cytochrome c. Histidine 45-54 cytochrome c, somatic Equus caballus 74-86 9379177-4 1997 Binding investigations on the natural substrates SCN- and I-, at varying pH and temperature, showed that their interaction with lactoperoxidase involves the protonation of a common site in proximity of the iron (possibly distal histidine). Histidine 228-237 lactoperoxidase Bos taurus 128-143 9272156-3 1997 We observed a novel germline mutation in the hMLH1 gene (His-->Pro at codon 329) in an HNPCC family. Histidine 57-60 mutL homolog 1 Homo sapiens 45-50 9268342-5 1997 In the present study, we show that LysoPLA I represents a new member of the serine hydrolase family with Ser-119, Asp-174, and His-208 composing the catalytic triad. Histidine 127-130 lysophospholipase 1 Mus musculus 35-44 9268342-6 1997 The Asp-174 and His-208 are conserved among several esterases and are demonstrated herein to be essential for LysoPLA I activity as the mutation of either residue to Ala abolished LysoPLA I activity, whereas the global conformation of the mutants remained unchanged. Histidine 16-19 lysophospholipase 1 Mus musculus 110-119 9268342-6 1997 The Asp-174 and His-208 are conserved among several esterases and are demonstrated herein to be essential for LysoPLA I activity as the mutation of either residue to Ala abolished LysoPLA I activity, whereas the global conformation of the mutants remained unchanged. Histidine 16-19 lysophospholipase 1 Mus musculus 180-189 9256252-2 1997 Here we describe the high-level synthesis in Escherichia coli, and purification in the monomeric form, of a histidine-tagged full-length mature PrP (25-249) of bovine brain, termed His-PrP. Histidine 108-117 PRP@ Bos taurus 144-147 9256252-2 1997 Here we describe the high-level synthesis in Escherichia coli, and purification in the monomeric form, of a histidine-tagged full-length mature PrP (25-249) of bovine brain, termed His-PrP. Histidine 108-117 PRP@ Bos taurus 185-188 9256252-2 1997 Here we describe the high-level synthesis in Escherichia coli, and purification in the monomeric form, of a histidine-tagged full-length mature PrP (25-249) of bovine brain, termed His-PrP. Histidine 181-184 PRP@ Bos taurus 144-147 9256252-2 1997 Here we describe the high-level synthesis in Escherichia coli, and purification in the monomeric form, of a histidine-tagged full-length mature PrP (25-249) of bovine brain, termed His-PrP. Histidine 181-184 PRP@ Bos taurus 185-188 9256252-3 1997 Based on biochemical and spectroscopic data, His-PrP displays characteristics expected for the PrP(C) isoform. Histidine 45-48 PRP@ Bos taurus 49-52 9150409-6 1997 In addition, a dramatic change in the catalytic activity was observed when the histidine residue (27d) in the CDR1 light chain was replaced with alanine. Histidine 79-88 cerebellar degeneration related protein 1 Homo sapiens 110-114 9092568-4 1997 When expressed in Xenopus laevis oocytes, PHT1 cRNA induced high affinity proton-dependent histidine transport activity. Histidine 91-100 solute carrier family 15 member 4 S homeolog Xenopus laevis 42-46 9173902-2 1997 In the present study we performed site-directed mutagenesis of the seven residues (Thr-38, Arg-47, Leu-54, Cys-87, Val-151, Arg-170 and Gln-172) of DD1 to the corresponding residues (Val, His, Val, Ser, Met, His and Leu respectively) of DD2. Histidine 188-191 aldo-keto reductase family 1 member C1 Homo sapiens 148-151 9173902-2 1997 In the present study we performed site-directed mutagenesis of the seven residues (Thr-38, Arg-47, Leu-54, Cys-87, Val-151, Arg-170 and Gln-172) of DD1 to the corresponding residues (Val, His, Val, Ser, Met, His and Leu respectively) of DD2. Histidine 208-211 aldo-keto reductase family 1 member C1 Homo sapiens 148-151 9116048-5 1997 Recombinant rat C5a with a 6 histidine tag at the N-terminus was expressed in bacteria, purified and renatured. Histidine 29-38 complement C5 Rattus norvegicus 16-19 9048595-2 1997 Somatostatin inhibited basal and gastrin-stimulated histamine synthesis through a dual mechanism involving a decrease in the affinity of histidine decarboxylase (HDC) for its substrate (L-histidine) and a reduction in the number of functional HDC molecules. Histidine 186-197 histidine decarboxylase Oryctolagus cuniculus 137-160 9048595-4 1997 Furthermore, forskolin was shown to reverse the inhibitory effect of H-89 and to prevent the somatostatin-induced reduction in HDC affinity for L-histidine. Histidine 144-155 histidine decarboxylase Oryctolagus cuniculus 127-130 8993325-0 1997 A lysine 73-->histidine variant of yeast iso-1-cytochrome c: evidence for a native-like intermediate in the unfolding pathway and implications for m value effects. Histidine 17-26 threonine ammonia-lyase ILV1 Saccharomyces cerevisiae S288C 44-49 8993325-1 1997 In this paper we report thermodynamic studies on a variant of yeast iso-1-cytochrome c in which a surface lysine residue at position 73 has been replaced with a histidine (H73). Histidine 161-170 threonine ammonia-lyase ILV1 Saccharomyces cerevisiae S288C 68-73 9016654-3 1996 TIF1 beta, TIF1 alpha, PML and efp belong to a characteristic subgroup of RING finger proteins that contain one or two other Cys/His-rich clusters (B boxes) and a putative coiled-coil in addition to the classical C3HC4 RING finger motif (RBCC configuration). Histidine 129-132 PML nuclear body scaffold Homo sapiens 23-26 8954946-2 1996 Using histidine-tagged TBP as a ligand for affinity-purification of proteins bound to TBP, we purified a 120-kD protein, termed TBP-interacting protein 120 (TIP120), from rat liver nuclear extracts. Histidine 6-15 TATA box binding protein Rattus norvegicus 23-26 8954946-2 1996 Using histidine-tagged TBP as a ligand for affinity-purification of proteins bound to TBP, we purified a 120-kD protein, termed TBP-interacting protein 120 (TIP120), from rat liver nuclear extracts. Histidine 6-15 TATA box binding protein Rattus norvegicus 86-89 8947475-3 1996 The C-terminus (His-Lys-Met) of trihydroxycoprostanoyl-CoA oxidase did not seem to interact with the C-terminal peroxisomal targeting signal 1 (PTS1) import receptor, although the tripeptide fits the rule of conserved PTS1 variants for targeting of proteins to glycosomes of Trypanosomatidae. Histidine 16-19 acyl-CoA oxidase 2 Rattus norvegicus 32-66 8931940-2 1996 A novel artificial peptide named HPH-Pep, comprising a pyridine and two histidine units, was synthesized. Histidine 72-81 progestagen associated endometrial protein Homo sapiens 37-40 8816461-3 1996 For the yeast Saccharomyces cerevisiae, the Upf1 protein (Upf1p), which contains a cysteine- and histidine-rich region and nucleoside triphosphate hydrolysis and helicase motifs, was shown to be a trans-acting factor in this decay pathway. Histidine 97-106 ATP-dependent RNA helicase NAM7 Saccharomyces cerevisiae S288C 44-48 8816461-3 1996 For the yeast Saccharomyces cerevisiae, the Upf1 protein (Upf1p), which contains a cysteine- and histidine-rich region and nucleoside triphosphate hydrolysis and helicase motifs, was shown to be a trans-acting factor in this decay pathway. Histidine 97-106 ATP-dependent RNA helicase NAM7 Saccharomyces cerevisiae S288C 58-63 8816462-2 1996 In the yeast Saccharomyces cerevisiae, the Upf1 protein (Upf1p), which contains a cysteine- and histidine-rich region and nucleoside triphosphate hydrolysis and helicase motifs, was shown to be a trans-acting factor in this decay pathway. Histidine 96-105 ATP-dependent RNA helicase NAM7 Saccharomyces cerevisiae S288C 43-47 8816462-2 1996 In the yeast Saccharomyces cerevisiae, the Upf1 protein (Upf1p), which contains a cysteine- and histidine-rich region and nucleoside triphosphate hydrolysis and helicase motifs, was shown to be a trans-acting factor in this decay pathway. Histidine 96-105 ATP-dependent RNA helicase NAM7 Saccharomyces cerevisiae S288C 57-62 8816462-11 1996 In this report, we describe the identification and biochemical characterization of mutations in the amino-terminal cysteine- and histidine-rich region of Upf1p that have normal nonsense-mediated mRNA decay activities but are able to suppress leu2-2 and tyr7-1 nonsense alleles. Histidine 129-138 ATP-dependent RNA helicase NAM7 Saccharomyces cerevisiae S288C 154-159 8816462-14 1996 Mutations in the cysteine- and histidine-rich region of Upf1p abolish Upf1p-Upf2p interaction. Histidine 31-40 ATP-dependent RNA helicase NAM7 Saccharomyces cerevisiae S288C 56-61 8816462-14 1996 Mutations in the cysteine- and histidine-rich region of Upf1p abolish Upf1p-Upf2p interaction. Histidine 31-40 ATP-dependent RNA helicase NAM7 Saccharomyces cerevisiae S288C 70-75 8843163-0 1996 Identification of the histidine residues involved in substrate recognition by a rat H+/peptide cotransporter, PEPT1. Histidine 22-31 solute carrier family 15 member 1 Rattus norvegicus 110-115 8843163-4 1996 When expressed in Xenopus oocytes, replacement of either histidine 57 or histidine 121 of the rat PEPT1 with glutamine by site-directed mutagenesis eliminated ceftibuten and [14C]glycylsarcosine transport activities. Histidine 57-66 solute carrier family 15 member 1 Rattus norvegicus 98-103 8843163-4 1996 When expressed in Xenopus oocytes, replacement of either histidine 57 or histidine 121 of the rat PEPT1 with glutamine by site-directed mutagenesis eliminated ceftibuten and [14C]glycylsarcosine transport activities. Histidine 73-82 solute carrier family 15 member 1 Rattus norvegicus 98-103 8808628-0 1996 A cluster of cytoplasmic histidine residues specifies pH dependence of the AE2 plasma membrane anion exchanger. Histidine 25-34 solute carrier family 4 member 2 Homo sapiens 75-78 8808628-3 1996 The data in this paper identify a histidine-rich sequence within the cytoplasmic domain of the nonerythroid anion exchanger, AE2, that serves as an intracellular pH "sensor" that modulates anion exchange activity within the physiological range of cytoplasmic pH. Histidine 34-43 solute carrier family 4 member 2 Homo sapiens 125-128 8836129-0 1996 Histidine residues in rabbit liver microsomal cytochrome P-450 2B4 control electron transfer from NADPH-cytochrome P-450 reductase and cytochrome b5. Histidine 0-9 cytochrome P450 2B4 Oryctolagus cuniculus 46-66 8836129-1 1996 Treatment of cytochrome P-450 2B4 (P-450 2B4) with diethylpyrocarbonate to introduce 10-11 equivalents of acylating agent per polypeptide chain resulted in the selective derivatization of histidine residues characterized by differential susceptibility toward the modifier. Histidine 188-197 cytochrome P450 2B4 Oryctolagus cuniculus 13-33 8798433-4 1996 The murine Cux-2 homeobox was similar to Drosophila cut and encoded a homeodomain that contained a characteristic histidine residue at position 50. Histidine 114-123 cut-like homeobox 2 Mus musculus 11-16 8877818-2 1996 The amplification was achieved using two primers which correspond to TRH progenitor sequence (Lys/Arg-Arg-Gln-His-Pro-Gly-Lys/Arg-Arg). Histidine 110-113 thyrotropin-releasing hormone L homeolog Xenopus laevis 69-72 8661426-6 1996 When the catalytically inactive, histidine-tagged mutant PKR protein [His-PKR(K296R)] was examined as a substrate for purified wild-type PKR, the intermolecular phosphorylation of His-PKR(K296R) was efficiently catalyzed by dsRNA-activated PKR but not by heparin-activated PKR. Histidine 33-42 eukaryotic translation initiation factor 2 alpha kinase 2 Homo sapiens 57-60 8661426-6 1996 When the catalytically inactive, histidine-tagged mutant PKR protein [His-PKR(K296R)] was examined as a substrate for purified wild-type PKR, the intermolecular phosphorylation of His-PKR(K296R) was efficiently catalyzed by dsRNA-activated PKR but not by heparin-activated PKR. Histidine 33-42 eukaryotic translation initiation factor 2 alpha kinase 2 Homo sapiens 74-77 8661426-6 1996 When the catalytically inactive, histidine-tagged mutant PKR protein [His-PKR(K296R)] was examined as a substrate for purified wild-type PKR, the intermolecular phosphorylation of His-PKR(K296R) was efficiently catalyzed by dsRNA-activated PKR but not by heparin-activated PKR. Histidine 33-42 eukaryotic translation initiation factor 2 alpha kinase 2 Homo sapiens 74-77 8661426-6 1996 When the catalytically inactive, histidine-tagged mutant PKR protein [His-PKR(K296R)] was examined as a substrate for purified wild-type PKR, the intermolecular phosphorylation of His-PKR(K296R) was efficiently catalyzed by dsRNA-activated PKR but not by heparin-activated PKR. Histidine 33-42 eukaryotic translation initiation factor 2 alpha kinase 2 Homo sapiens 74-77 8661426-6 1996 When the catalytically inactive, histidine-tagged mutant PKR protein [His-PKR(K296R)] was examined as a substrate for purified wild-type PKR, the intermolecular phosphorylation of His-PKR(K296R) was efficiently catalyzed by dsRNA-activated PKR but not by heparin-activated PKR. Histidine 33-42 eukaryotic translation initiation factor 2 alpha kinase 2 Homo sapiens 74-77 8661426-6 1996 When the catalytically inactive, histidine-tagged mutant PKR protein [His-PKR(K296R)] was examined as a substrate for purified wild-type PKR, the intermolecular phosphorylation of His-PKR(K296R) was efficiently catalyzed by dsRNA-activated PKR but not by heparin-activated PKR. Histidine 33-42 eukaryotic translation initiation factor 2 alpha kinase 2 Homo sapiens 74-77 8661426-6 1996 When the catalytically inactive, histidine-tagged mutant PKR protein [His-PKR(K296R)] was examined as a substrate for purified wild-type PKR, the intermolecular phosphorylation of His-PKR(K296R) was efficiently catalyzed by dsRNA-activated PKR but not by heparin-activated PKR. Histidine 70-73 eukaryotic translation initiation factor 2 alpha kinase 2 Homo sapiens 57-60 8661426-6 1996 When the catalytically inactive, histidine-tagged mutant PKR protein [His-PKR(K296R)] was examined as a substrate for purified wild-type PKR, the intermolecular phosphorylation of His-PKR(K296R) was efficiently catalyzed by dsRNA-activated PKR but not by heparin-activated PKR. Histidine 70-73 eukaryotic translation initiation factor 2 alpha kinase 2 Homo sapiens 74-77 8661426-6 1996 When the catalytically inactive, histidine-tagged mutant PKR protein [His-PKR(K296R)] was examined as a substrate for purified wild-type PKR, the intermolecular phosphorylation of His-PKR(K296R) was efficiently catalyzed by dsRNA-activated PKR but not by heparin-activated PKR. Histidine 70-73 eukaryotic translation initiation factor 2 alpha kinase 2 Homo sapiens 74-77 8661426-6 1996 When the catalytically inactive, histidine-tagged mutant PKR protein [His-PKR(K296R)] was examined as a substrate for purified wild-type PKR, the intermolecular phosphorylation of His-PKR(K296R) was efficiently catalyzed by dsRNA-activated PKR but not by heparin-activated PKR. Histidine 70-73 eukaryotic translation initiation factor 2 alpha kinase 2 Homo sapiens 74-77 8661426-6 1996 When the catalytically inactive, histidine-tagged mutant PKR protein [His-PKR(K296R)] was examined as a substrate for purified wild-type PKR, the intermolecular phosphorylation of His-PKR(K296R) was efficiently catalyzed by dsRNA-activated PKR but not by heparin-activated PKR. Histidine 70-73 eukaryotic translation initiation factor 2 alpha kinase 2 Homo sapiens 74-77 8661426-6 1996 When the catalytically inactive, histidine-tagged mutant PKR protein [His-PKR(K296R)] was examined as a substrate for purified wild-type PKR, the intermolecular phosphorylation of His-PKR(K296R) was efficiently catalyzed by dsRNA-activated PKR but not by heparin-activated PKR. Histidine 70-73 eukaryotic translation initiation factor 2 alpha kinase 2 Homo sapiens 74-77 8661426-6 1996 When the catalytically inactive, histidine-tagged mutant PKR protein [His-PKR(K296R)] was examined as a substrate for purified wild-type PKR, the intermolecular phosphorylation of His-PKR(K296R) was efficiently catalyzed by dsRNA-activated PKR but not by heparin-activated PKR. Histidine 180-183 eukaryotic translation initiation factor 2 alpha kinase 2 Homo sapiens 57-60 8661426-6 1996 When the catalytically inactive, histidine-tagged mutant PKR protein [His-PKR(K296R)] was examined as a substrate for purified wild-type PKR, the intermolecular phosphorylation of His-PKR(K296R) was efficiently catalyzed by dsRNA-activated PKR but not by heparin-activated PKR. Histidine 180-183 eukaryotic translation initiation factor 2 alpha kinase 2 Homo sapiens 74-77 8661426-6 1996 When the catalytically inactive, histidine-tagged mutant PKR protein [His-PKR(K296R)] was examined as a substrate for purified wild-type PKR, the intermolecular phosphorylation of His-PKR(K296R) was efficiently catalyzed by dsRNA-activated PKR but not by heparin-activated PKR. Histidine 180-183 eukaryotic translation initiation factor 2 alpha kinase 2 Homo sapiens 74-77 8661426-6 1996 When the catalytically inactive, histidine-tagged mutant PKR protein [His-PKR(K296R)] was examined as a substrate for purified wild-type PKR, the intermolecular phosphorylation of His-PKR(K296R) was efficiently catalyzed by dsRNA-activated PKR but not by heparin-activated PKR. Histidine 180-183 eukaryotic translation initiation factor 2 alpha kinase 2 Homo sapiens 74-77 8661426-6 1996 When the catalytically inactive, histidine-tagged mutant PKR protein [His-PKR(K296R)] was examined as a substrate for purified wild-type PKR, the intermolecular phosphorylation of His-PKR(K296R) was efficiently catalyzed by dsRNA-activated PKR but not by heparin-activated PKR. Histidine 180-183 eukaryotic translation initiation factor 2 alpha kinase 2 Homo sapiens 74-77 8661426-6 1996 When the catalytically inactive, histidine-tagged mutant PKR protein [His-PKR(K296R)] was examined as a substrate for purified wild-type PKR, the intermolecular phosphorylation of His-PKR(K296R) was efficiently catalyzed by dsRNA-activated PKR but not by heparin-activated PKR. Histidine 180-183 eukaryotic translation initiation factor 2 alpha kinase 2 Homo sapiens 74-77 8766941-1 1996 A clinical, prospective experiment was carried out to determine whether long-term intranasal administration of the growth hormone-releasing peptide hexarelin (His-D-2-methyl-Trp-Ala-Trp-D-Phe -Lys-NH2) affects pituitary growth hormone secretion. Histidine 159-162 ghrelin and obestatin prepropeptide Homo sapiens 115-147 8919915-7 1996 Three histidine-rich motifs (HX3H, HX2HH and HX2HH) were found in the A. thaliana ORF which are also present in the yeast ERG 3 gene. Histidine 6-15 C-5 sterol desaturase Saccharomyces cerevisiae S288C 122-127 8814878-5 1996 Importantly, the effective substitution of the oxazole O-1 for the histidine N-1 further illustrates that this group does not require deprotonation upon metal complexation, oxygen activation, or the ensuing oxidation reactions, that the functional bleomycin A2 tautomer is the imidazole N"-H tautomer, and that the imidazole N"-H functionality is not contributing to the polynucleotide recognition through H-bonding to the phosphate backbone or nucleotide bases. Histidine 67-76 immunoglobulin kappa variable 2D-40 Homo sapiens 55-58 8593783-6 1996 Mutations in the human IGF-I receptor were either replacement of tyrosines 1250 and 1251 with phenylalanine and histidine (yyFH), respectively, or replacement of the conserved distal tyrosine (position 1316) with phenylalanine (yCF). Histidine 112-121 insulin like growth factor 1 receptor Homo sapiens 23-37 7599635-0 1995 Four new adenosine deaminase mutations, altering a zinc-binding histidine, two conserved alanines, and a 5" splice site. Histidine 64-73 adenosine deaminase Homo sapiens 9-28 7838710-6 1994 The results of the experiments using bacterially expressed MSSP-2, and its deletion mutants, as histidine fusion proteins suggested that the binding specificity of MSSP-2 to double- and single-stranded DNA is the same as that of MSSP-1, and that the RNP consensus sequences are required for the DNA binding of the protein. Histidine 96-105 RNA binding motif single stranded interacting protein 1 Homo sapiens 164-170 7998988-7 1994 Alignment with subtilisin-like serine peptidases identified Asp44, His264 and Ser449 as the catalytic triad, thus defining an extra domain of approximately 200 amino acids between the catalytic Asp and His in TPP II as compared with other subtilases. Histidine 67-70 tripeptidyl peptidase II Mus musculus 209-215 7947824-3 1994 One mutant, RBP/H3(A), with His residues introduced at the positions 46, 54, and 56 in the polypeptide sequence was shown to bind Zn(II) specifically with a stoichiometry of 1 and a corresponding dissociation constant equal to 36 +/- 10 nM. Histidine 28-31 retinol binding protein 4 Homo sapiens 12-15 7947988-0 1994 Site-directed mutagenesis of human ferrochelatase: identification of histidine-263 as a binding site for metal ions. Histidine 69-78 ferrochelatase Homo sapiens 35-49 7947988-3 1994 To attempt to clarify the binding site of ferrous ion, we converted four highly conserved histidine residues in human ferrochelatase to alanine, using site-directed mutagenesis. Histidine 90-99 ferrochelatase Homo sapiens 118-132 7947988-10 1994 These results indicate that the binding site for metal ions in ferrochelatase is distinct from that for the porphyrin, and suggest that histidine-263 contributes significantly to the binding of metal ions. Histidine 136-145 ferrochelatase Homo sapiens 63-77 7947684-0 1994 Eight histidine residues are catalytically essential in a membrane-associated iron enzyme, stearoyl-CoA desaturase, and are conserved in alkane hydroxylase and xylene monooxygenase. Histidine 6-15 stearoyl-CoA desaturase Rattus norvegicus 91-114 7947684-7 1994 In order to examine the functional role of these conserved His residues, we have made use of the ability of the rat delta 9 desaturase gene to complement a yeast strain deficient in the delta 9 desaturase gene function (ole1). Histidine 59-62 stearoyl-CoA 9-desaturase Saccharomyces cerevisiae S288C 220-224 7947684-10 1994 In contrast, mutation of three nonconserved flanking His residues or a partially conserved Arg residue within the conserved motif to Ala allowed for complementation of the ole1 phenotype. Histidine 53-56 stearoyl-CoA 9-desaturase Saccharomyces cerevisiae S288C 172-176 7925571-7 1994 The pH dependence of IgG1 or Fc fragment binding to FcRn is consistent with the localization of the FcRn interaction site to a region of the Fc that encompasses two histidine residues (His 310 and His 433). Histidine 165-174 LOC105243590 Mus musculus 21-25 7925571-7 1994 The pH dependence of IgG1 or Fc fragment binding to FcRn is consistent with the localization of the FcRn interaction site to a region of the Fc that encompasses two histidine residues (His 310 and His 433). Histidine 185-188 LOC105243590 Mus musculus 21-25 7925571-7 1994 The pH dependence of IgG1 or Fc fragment binding to FcRn is consistent with the localization of the FcRn interaction site to a region of the Fc that encompasses two histidine residues (His 310 and His 433). Histidine 197-200 LOC105243590 Mus musculus 21-25 8076694-3 1994 Chemical modification of cysteine by iodoacetic acid, and histidine by diethylpyrocarbonate, resulted in a near complete inhibition of 65Zn-binding to TP2. Histidine 58-67 transition protein 2 Rattus norvegicus 151-154 8035800-4 1994 The iap genes encode a C3HC4 (or RING) finger motif found in a number of transcriptional regulatory proteins, as well as two additional Cys/His motifs (baculovirus iap repeats). Histidine 140-143 magnesium transporter 1 Homo sapiens 4-7 8022819-4 1994 PLC-gamma 1 with defective enzymatic activity was synthesized by substituting phenylalanine for histidine within the PLC-gamma 1 catalytic domain at amino acids 335 and 380, and mutant enzymes were expressed using a vaccinia expression system. Histidine 96-105 phospholipase C, gamma 1 Mus musculus 0-11 8027057-1 1994 The catalysis of the hydration of CO2 by human carbonic anhydrase II (HCA II) includes the transfer of a proton from zinc-bound water to histidine 64 utilizing a network of intervening hydrogen-bonded water molecules, then the proton is transferred to buffer in solution. Histidine 137-146 carbonic anhydrase 2 Homo sapiens 47-68 8037675-3 1994 Ni2+ binds to a site in the N-terminal region of the protein which is partially blocked by the presence of a propeptide as in proalbumin (proAlb) Varese (Arg-2-->His), proAlb Christchurch (Arg-1-->Gln) and proAlb Blenheim (Asp1-->Val) and by the presence of only an extra Arg residue (Arg-1) as in Arg-Alb and albumin (Alb) Redhill. Histidine 165-168 arginase 2 Homo sapiens 154-159 8010958-0 1994 The effect of replacing the conserved active-site residues His-264, Asp-312 and Arg-314 on the binding and catalytic properties of Escherichia coli citrate synthase. Histidine 59-62 citrate synthase Sus scrofa 148-164 8010958-2 1994 Active-site residues Arg-314, Asp-312 and His-264 in Escherichia coli citrate synthase, which are involved in oxaloacetate binding, were converted by site-directed mutagenesis to Gln-314, Asn-312 and Asn-264 respectively. Histidine 42-45 citrate synthase Sus scrofa 70-86 8204623-7 1994 Evidence reported here, gathered from 31 replacement analogs, supports the idea that in the absence of the requisite carboxyl group at position 9, histidine utilizes Asp21 or Asp15 as a compensatory site. Histidine 147-156 beta-secretase 2 Homo sapiens 166-171 8120011-5 1994 Comparison of subtilisin peptide maps of active and inactivated enzymes showed a difference in one histidine-containing peptide, the sequence of which is YNTPH277GVAN for propanediol oxidoreductase and YNLPH277GV for alcohol dehydrogenase II. Histidine 99-108 oxidoreductase Escherichia coli 183-197 7866410-0 1994 Marked zinc activation of ester hydrolysis by a mutation, 67-His (CAT) to Arg (CGT), in the active site of human carbonic anhydrase I. Histidine 61-64 UDP glycosyltransferase 8 Homo sapiens 79-82 7866410-0 1994 Marked zinc activation of ester hydrolysis by a mutation, 67-His (CAT) to Arg (CGT), in the active site of human carbonic anhydrase I. Histidine 61-64 carbonic anhydrase 1 Homo sapiens 113-133 8142888-0 1994 Positions of His-64 and a bound water in human carbonic anhydrase II upon binding three structurally related inhibitors. Histidine 13-16 carbonic anhydrase 2 Homo sapiens 47-68 8136024-3 1993 The further substitution of Asp for B10 His in [B16 Phe, B26 Phe]insulin raises its activity to approximately twofold greater than natural insulin, an increase of approximately fivefold over the parent compound. Histidine 40-43 ectonucleotide pyrophosphatase/phosphodiesterase 3 Homo sapiens 36-39 8378358-3 1993 When various preparations of glyceraldehyde-3-phosphate dehydrogenase containing 0-7.0 equivalent of HNE-histidine residues per subunit were obtained by incubating samples of glyceraldehyde-3-phosphate dehydrogenase with increased amounts of HNE and subjected to immunoblotting with the HNE-specific antibody, the intensities of the blots were directly proportional to the number of HNE-histidine adducts as measured directly by amino acid analysis. Histidine 105-114 glyceraldehyde-3-phosphate dehydrogenase Rattus norvegicus 29-69 8378358-3 1993 When various preparations of glyceraldehyde-3-phosphate dehydrogenase containing 0-7.0 equivalent of HNE-histidine residues per subunit were obtained by incubating samples of glyceraldehyde-3-phosphate dehydrogenase with increased amounts of HNE and subjected to immunoblotting with the HNE-specific antibody, the intensities of the blots were directly proportional to the number of HNE-histidine adducts as measured directly by amino acid analysis. Histidine 387-396 glyceraldehyde-3-phosphate dehydrogenase Rattus norvegicus 29-69 8221927-5 1993 At the same time we observed a high rate of reversion in the meth, his and trp loci of the cdc2-1 mutant under restrictive conditions. Histidine 67-70 thymidylate synthase Saccharomyces cerevisiae S288C 91-97 8318003-7 1993 Peak 1, a zinc-dependent enzyme with serine and histidine in the active site, exhibited an M(r) of 75,000 on Superose 12 and was poorly inhibited by V3 loop peptides. Histidine 48-57 pseudopodium enriched atypical kinase 1 Homo sapiens 0-6 8496014-1 1993 Bombesin (Bn, pGlu-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2) is one of the most potent peptides, possessing a variety of physiological and pharmacological functions. Histidine 59-62 gastrin releasing peptide Homo sapiens 0-8 8384830-6 1993 Comparison with sequences of other cytochromes c indicated the closest similarity to cytochrome c from snapping turtle (Chelydra serpentina) with substitutions at five positions corresponding to residues 32 (His-->Asn), 44 (Glu-->Pro), 89 (Ala-->Pro), 100 (Asp-->Glu), and 104 (Lys-->Asn), respectively. Histidine 208-211 cytochrome c Alligator mississippiensis 85-97 8486232-7 1993 These findings suggest that the basic amino acid at position 13, which is present only on the DR2 and DR4 B1 molecules (Arg on DR2 and His on DR4), may contribute to the susceptibility to autoimmune hepatitis of Japanese. Histidine 135-138 major histocompatibility complex, class II, DR beta 4 Homo sapiens 102-105 8486232-7 1993 These findings suggest that the basic amino acid at position 13, which is present only on the DR2 and DR4 B1 molecules (Arg on DR2 and His on DR4), may contribute to the susceptibility to autoimmune hepatitis of Japanese. Histidine 135-138 major histocompatibility complex, class II, DR beta 4 Homo sapiens 142-145 7510795-4 1993 On increasing the pH from 4.5 to 9.5 (at 25.0 degrees C), the affinity of BPTI, as well as bovine and porcine PSTI for cathepsin G increases thus reflecting the acidic-pK shift of the His-57 catalytic residue from approximately 6.9 in the free enzyme to approximately 5.0 in the serine proteinase:inhibitor complexes. Histidine 184-187 spleen trypsin inhibitor I Bos taurus 74-78 7510795-4 1993 On increasing the pH from 4.5 to 9.5 (at 25.0 degrees C), the affinity of BPTI, as well as bovine and porcine PSTI for cathepsin G increases thus reflecting the acidic-pK shift of the His-57 catalytic residue from approximately 6.9 in the free enzyme to approximately 5.0 in the serine proteinase:inhibitor complexes. Histidine 184-187 cathepsin G Bos taurus 119-130 1334481-0 1992 Conversion of the proximal histidine ligand to glutamine restores activity to an inactive mutant of cytochrome c peroxidase. Histidine 27-36 cytochrome-c peroxidase Saccharomyces cerevisiae S288C 100-123 1492975-4 1992 In this report a comparison of CH3O-Suc-Ala-Ala-Pro-Val-CH2Cl-inhibited elastase with HBP, its naturally occurring homologue selectively mutated in active serine and histidine, reveals that homotypic aggregation of monocytes and contraction of fibroblasts is specific for HBP. Histidine 166-175 azurocidin 1 Homo sapiens 86-89 1332761-10 1992 The excellent agreement between model compounds and isolated Cyt b559 reinforces the validity of the model of a heme iron coordinated to two histidine residues for Cyt b559. Histidine 141-150 mitochondrially encoded cytochrome b Homo sapiens 61-66 1292009-8 1992 These mutations may affect tyrosinase activity by either altering the position of the alpha helical domains and thus preventing proper copper binding to the histidine ligands, or affecting a catalytic or substrate binding site located between the two alpha helical domains. Histidine 157-166 tyrosinase Homo sapiens 27-37 1359165-4 1992 The increased HLA-DQB1 alleles have a histidine residue in common at the 30th codon for the HLA-DQ beta chain. Histidine 38-47 major histocompatibility complex, class II, DQ beta 1 Homo sapiens 14-22 1359165-4 1992 The increased HLA-DQB1 alleles have a histidine residue in common at the 30th codon for the HLA-DQ beta chain. Histidine 38-47 major histocompatibility complex, class II, DQ beta 1 Homo sapiens 14-17 1354193-9 1992 These findings suggest that the basic amino acid at position 13, which is present only on the DR2 and DR4 B1 molecules (Arg on DR2 and His on DR4), contributes to the susceptibility to autoimmune hepatitis among the Japanese. Histidine 135-138 major histocompatibility complex, class II, DR beta 4 Homo sapiens 102-105 1354193-9 1992 These findings suggest that the basic amino acid at position 13, which is present only on the DR2 and DR4 B1 molecules (Arg on DR2 and His on DR4), contributes to the susceptibility to autoimmune hepatitis among the Japanese. Histidine 135-138 major histocompatibility complex, class II, DR beta 4 Homo sapiens 142-145 16668921-6 1992 The smaller extensin monomer reported here (Superose-6 peak 2 [SP2]) was compositionally similar to typical dicot extensins such as tomato P1, mainly consisting of Hyp, Thr, Ser, Pro, Val, Tyr, Lys, His, abundant arabinose, and a small but significant galactose content. Histidine 199-202 extensin-3-like Solanum lycopersicum 12-20 1577733-2 1992 These studies establish that the proton resonances of His(B5) and His(B10) are useful signatures of aggregation and conformation. Histidine 54-57 ectonucleotide pyrophosphatase/phosphodiesterase 3 Homo sapiens 70-73 1577733-2 1992 These studies establish that the proton resonances of His(B5) and His(B10) are useful signatures of aggregation and conformation. Histidine 66-69 ectonucleotide pyrophosphatase/phosphodiesterase 3 Homo sapiens 70-73 1544468-7 1992 The results obtained for human pancreatic lipase corroborate the inhibition mechanism of THL found on the porcine enzyme, and are in full agreement with the identification of the Ser-152 ... His-263 ... Asp-176 catalytic triad in the X-ray structure of human pancreatic lipase. Histidine 191-194 pancreatic lipase Homo sapiens 31-48 1544468-7 1992 The results obtained for human pancreatic lipase corroborate the inhibition mechanism of THL found on the porcine enzyme, and are in full agreement with the identification of the Ser-152 ... His-263 ... Asp-176 catalytic triad in the X-ray structure of human pancreatic lipase. Histidine 191-194 pancreatic lipase Homo sapiens 259-276 1545235-2 1992 The deduced protein is structurally similar to the yeast KEX2 prohormone endoprotease including the conserved Asp, His, and Ser catalytic triad residues characteristic of the subtilisin family. Histidine 115-118 kexin KEX2 Saccharomyces cerevisiae S288C 57-61 1370297-2 1992 The ovarian autoimmune disease is induced in B6AF1 mice by a 15-amino acid peptide (Cys-Ser-Asn-Ser-Ser-Ser-Ser-Gln-Phe-Gln-Ile-His-Gly-Pro-Arg) from mouse ZP3, the sperm-binding component of the zona pellucida that surrounds growing and mature oocytes. Histidine 128-131 zona pellucida glycoprotein 3 Mus musculus 156-159 1918039-0 1991 Modification of histidine 56 in adrenodoxin with diethyl pyrocarbonate inhibited the interaction with cytochrome P-450scc and adrenodoxin reductase. Histidine 16-25 ferredoxin reductase Bos taurus 126-147 1665895-3 1991 Furthermore actinomycin D was able to displace [125I]-His-NKA from NK2 receptor sites of the rat small intestine smooth muscle membranes. Histidine 54-57 tachykinin receptor 2 Rattus norvegicus 67-79 1911719-6 1991 Nominally, DMEM contains 270 microM histidine but no copper, whereas F12 contains 135 microM histidine and 10 nM copper; addition of copper (as much as 5 microM) to DMEM or of histidine (as much as 2.16 mM) to F12 did not overcome the differences between the media in supporting LDL oxidation by endothelial cells. Histidine 93-102 coagulation factor XII Homo sapiens 69-72 1911719-6 1991 Nominally, DMEM contains 270 microM histidine but no copper, whereas F12 contains 135 microM histidine and 10 nM copper; addition of copper (as much as 5 microM) to DMEM or of histidine (as much as 2.16 mM) to F12 did not overcome the differences between the media in supporting LDL oxidation by endothelial cells. Histidine 93-102 coagulation factor XII Homo sapiens 69-72 1799700-6 1991 The phenotype of the virA112 mutant resulted from a glycine to glutamic acid change near His-474, the site of VirA autophosphorylation. Histidine 89-92 two-component VirA-like sensor kinase Agrobacterium tumefaciens 110-114 2049091-6 1991 However, azurocidin has Gly for Ser and Ser for His substitutions in the catalytic triad. Histidine 48-51 azurocidin 1 Homo sapiens 9-19 2043465-8 1991 Following polymerase chain reaction (PCR) amplification, cloning and sequencing of exon 2 of spectrin alpha-gene in the father, we found the G----A substitution at position 2 of codon 22 (CGT----CAT; Arg----His). Histidine 207-210 UDP glycosyltransferase 8 Homo sapiens 188-191 1996120-0 1991 The TIS11 primary response gene is a member of a gene family that encodes proteins with a highly conserved sequence containing an unusual Cys-His repeat. Histidine 142-145 zinc finger protein 36 Rattus norvegicus 4-9 1998686-8 1991 Potential catalytic roles are assigned to the conserved His 214, Cys 262, Asp 295, and Asp 296 residues of mammalian adenosine deaminases and the corresponding conserved amino acid residues in bacterial adenosine deaminase and the eukaryotic AMP deaminases. Histidine 56-59 adenosine deaminase Homo sapiens 117-136 1901988-7 1991 In addition, we show that a conserved histidine residue, located 7 amino acids (i.e., two alpha-helical turns) C-terminally to the 5th leucine in Fos and Jun, is also important for complex formation. Histidine 38-47 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 146-149 1988069-4 1991 The amino-terminal domain of rat hemopexin contains two histidine residues that are conserved in the human and rat sequences and are the most likely heme axial ligands. Histidine 56-65 hemopexin Rattus norvegicus 33-42 2046459-0 1991 Intranasal activity of the growth hormone releasing peptide His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 in conscious dogs. Histidine 60-63 somatotropin Canis lupus familiaris 27-41 2046459-1 1991 This series of experiments was conducted to evaluate the growth hormone (GH) releasing activity of intranasally administered His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 (GHRP-6, SK&F 110679) in conscious dogs. Histidine 125-128 somatotropin Canis lupus familiaris 57-71 1979919-7 1990 Modification of brush border membrane vesicles with the histidine-modifying reagent diethyl pyrocarbonate led to a strong irreversible inhibition of cephalexin uptake whereas the activity of aminopeptidase N remained unchanged. Histidine 56-65 alanyl aminopeptidase, membrane Sus scrofa 191-207 2147282-4 1990 Site-directed mutagenesis of the His-53, Asp-77, and Ser-138 residues of NS3 that compose the proposed catalytic triad implicates this domain as a serine protease. Histidine 33-36 KRAS proto-oncogene, GTPase Homo sapiens 73-76 2174256-0 1990 Multiple heme pocket subconformations of methemoglobin associated with distal histidine interactions. Histidine 78-87 hemoglobin subunit gamma 2 Homo sapiens 41-54 2174256-1 1990 Electron paramagnetic resonance spectra of methemoglobin reveal that, in addition to the major tetragonal high-spin aqueous complex and the low-spin hydroxide complex, three other complexes associated with the interaction of the distal histidine are resolved. Histidine 236-245 hemoglobin subunit gamma 2 Homo sapiens 43-56 2078626-5 1990 The pK value (7.1 +/- 0.1) calculated from this model corresponds to pKn of essential His-195. Histidine 86-89 protein kinase N1 Homo sapiens 69-72 2328319-10 1990 We found a G to A base substitution in the 22nd codon (CAT for CGT), which changes the normal arginine to a histidine. Histidine 108-117 UDP glycosyltransferase 8 Homo sapiens 63-66 1688433-2 1990 Analysis of a 953-base pair cDNA that encodes MMCP-2 revealed that this serine protease is a basically charged protein, possessing the histidine-aspartic acid-serine charge relay system that is characteristic of other serine proteases. Histidine 135-144 mast cell protease 2 Mus musculus 46-52 1688433-2 1990 Analysis of a 953-base pair cDNA that encodes MMCP-2 revealed that this serine protease is a basically charged protein, possessing the histidine-aspartic acid-serine charge relay system that is characteristic of other serine proteases. Histidine 135-144 complement component 1, s subcomponent 1 Mus musculus 72-87 25575548-9 2015 CONCLUSIONS: Three LoF mutations in HAL were associated with increased histidine levels, which in turn were shown to be inversely related to the risk of CHD among both African Americans and European Americans. Histidine 71-80 histidine ammonia-lyase Homo sapiens 36-39 25575548-3 2015 METHODS AND RESULTS: By conducting whole exome sequencing on 1152 African Americans in the Atherosclerosis Risk in Communities (ARIC) study and focusing on loss-of-function (LoF) variants, we identified 3 novel rare LoF variants in HAL, a gene that encodes histidine ammonia-lyase in the first step of histidine catabolism. Histidine 257-266 histidine ammonia-lyase Homo sapiens 232-235 8771178-1 1995 The structure of histidine 94-->aspartate (H94D) carbonic anhydrase II (CAII) crystallized in an orthorhombic space group has been determined to 2.5 A resolution. Histidine 17-26 carbonic anhydrase 2 Homo sapiens 52-73 8771178-1 1995 The structure of histidine 94-->aspartate (H94D) carbonic anhydrase II (CAII) crystallized in an orthorhombic space group has been determined to 2.5 A resolution. Histidine 17-26 carbonic anhydrase 2 Homo sapiens 75-79 34979251-2 2022 We found an OBP sequence from the stable fly, Stomoxys calcitrans, ScalOBP60, that has a 25 amino acid N-terminal extension with a high content of histidine and acidic amino acids, suggesting a possible metal binding activity. Histidine 147-156 Optix-binding protein Drosophila melanogaster 12-15 34948007-1 2021 Combined potentiometric titration and isothermal titration calorimetry (ITC) methods were used to study the interactions of nickel(II) ions with the N-terminal fragments and histidine-rich fragments of Hpn-like protein from two Helicobacter pylori strains (11637 and 26695). Histidine 174-183 hepsin Homo sapiens 202-205 33620265-2 2021 Taking advantage of the overexpressed CD44 receptor and mild acidic microenvironment of tumour cells, CD44-targeted pH-responsive micelles based on the self-assembly of histidine-hyaluronic acid-dodecylamine (His-HA-DA) were prepared for the delivery of doxorubicin (DOX). Histidine 169-178 CD44 molecule (Indian blood group) Homo sapiens 38-42 33620265-2 2021 Taking advantage of the overexpressed CD44 receptor and mild acidic microenvironment of tumour cells, CD44-targeted pH-responsive micelles based on the self-assembly of histidine-hyaluronic acid-dodecylamine (His-HA-DA) were prepared for the delivery of doxorubicin (DOX). Histidine 169-178 CD44 molecule (Indian blood group) Homo sapiens 102-106 34982449-5 2021 The replacement of Histidine (His) with Asparagine (Asn) at position 1568 in the topological domain of SCN9A channel protein provides new insights into the impaired excitation and inactivation patterns of sodium channels. Histidine 19-28 sodium voltage-gated channel alpha subunit 9 Homo sapiens 103-108 34982449-5 2021 The replacement of Histidine (His) with Asparagine (Asn) at position 1568 in the topological domain of SCN9A channel protein provides new insights into the impaired excitation and inactivation patterns of sodium channels. Histidine 30-33 sodium voltage-gated channel alpha subunit 9 Homo sapiens 103-108 34734351-2 2021 Histidine decarboxylase (HDC), the unique enzyme that converts L-histidine to histamine, is highly expressed in CD11b+ immature myeloid cells. Histidine 63-74 integrin subunit alpha M Homo sapiens 112-117 34606713-4 2021 We use histidine-heme loop formation methods, employing eight single histidine variants, to probe for denatured state conformational bias of a UBA(1) domain fused to the N-terminus of iso-1-cytochrome c (iso-1-Cytc). Histidine 7-16 eukaryotic translation initiation factor 1 Homo sapiens 204-214 34625786-10 2021 Moreover, the 6 x His tag provides a convenient tool for detecting the interactions of mouse CRP with ligands. Histidine 18-21 C-reactive protein, pentraxin-related Mus musculus 93-96 34436882-5 2021 Herein, we report the discovery and hit-to-lead optimization of first-in-class Nln activators based on histidine-containing dipeptide hits identified from a virtual screen. Histidine 103-112 neurolysin (metallopeptidase M3 family) Mus musculus 79-82 34209660-2 2021 One of the strongest genetic risk factors for AMD is a complement factor H (CFH) gene polymorphism characterized by a tyrosine-histidine change at amino acid position 402 (Y402H). Histidine 127-136 complement factor H Homo sapiens 55-74 34209660-2 2021 One of the strongest genetic risk factors for AMD is a complement factor H (CFH) gene polymorphism characterized by a tyrosine-histidine change at amino acid position 402 (Y402H). Histidine 127-136 complement factor H Homo sapiens 76-79 34122448-6 2021 The immunodominance of B-cell epitopes, total IgG titers and the levels of IFN-gamma and IL-17A from mice immunized with HI plus different adjuvants were different from each other, which may explain the difference in protective immunity observed in each immunized group. Histidine 121-123 interleukin 17A Mus musculus 89-95 35460908-4 2022 In brief, Met and glucose oxidase (GOx) was encapsulated into histidine/zeolitic imidazolate framework-8 (His/ZIF-8), which was followed by coating with Arg-Gly-Asp (RGD) peptides to obtain the desired nanomedicine (Met/GOx@His/ZIF-8~RGD). Histidine 62-71 hydroxyacid oxidase 1 Homo sapiens 18-33 35460908-4 2022 In brief, Met and glucose oxidase (GOx) was encapsulated into histidine/zeolitic imidazolate framework-8 (His/ZIF-8), which was followed by coating with Arg-Gly-Asp (RGD) peptides to obtain the desired nanomedicine (Met/GOx@His/ZIF-8~RGD). Histidine 62-71 hydroxyacid oxidase 1 Homo sapiens 35-38 35460908-4 2022 In brief, Met and glucose oxidase (GOx) was encapsulated into histidine/zeolitic imidazolate framework-8 (His/ZIF-8), which was followed by coating with Arg-Gly-Asp (RGD) peptides to obtain the desired nanomedicine (Met/GOx@His/ZIF-8~RGD). Histidine 62-71 hydroxyacid oxidase 1 Homo sapiens 220-223 35346814-2 2022 This biogenic amine is fermented by microorganisms from histidine through the activity of histidine decarboxylase. Histidine 56-65 Histidine decarboxylase Drosophila melanogaster 90-113 35427157-4 2022 Mutational analysis revealed that the predicted catalytic residues histidine-166 and cysteine-280 are critical for Cln5 thioesterase activity, uncovering a new cysteine-based catalytic mechanism for S-depalmitoylation enzymes. Histidine 67-76 CLN5 intracellular trafficking protein Homo sapiens 115-119 35229720-3 2022 However, little is known about how histidine is presented to Hdc as a precursor. Histidine 35-44 Histidine decarboxylase Drosophila melanogaster 61-64 35224154-3 2022 In many conditions, the histidine-rich region of HRGP strengthens ligand binding following interaction with Zn2+ or exposure to low pH, such as sites of tissue injury or tumor growth. Histidine 24-33 histidine rich glycoprotein Homo sapiens 49-53 2691018-5 1989 A point mutation at this location corresponds to a substitution of histidine for glutamine in the N-ras gene product, p21. Histidine 67-76 NRAS proto-oncogene, GTPase Homo sapiens 98-103 2613237-2 1989 A mutation of thymine to adenine in the prealbumin (transthyretin) gene at the position corresponding to the second base of codon 58 in the prealbumin mRNA gives a histidine for leucine substitution in the plasma protein. Histidine 164-173 transthyretin Homo sapiens 52-65 2501305-1 1989 We have reacted acrolein with human carbonic anhydrase II using conditions reported to result in maximal formylethylation of exposed histidine and lysine residues (Pocker, Y., and Janjic, N. (1988) J. Biol. Histidine 133-142 carbonic anhydrase 2 Homo sapiens 36-57 2501305-9 1989 These results support the proposal of Pocker and Janjic and the suggested role of histidine 64 in carbonic anhydrase II as a proton shuttle residue that transfers a proton from zinc-bound water to buffer in solution. Histidine 82-91 carbonic anhydrase 2 Homo sapiens 98-119 2476788-1 1989 Recent studies show that substitutions for the His in position 12 of bombesin (Bn) are important in determining antagonist activity. Histidine 47-50 gastrin releasing peptide Homo sapiens 69-77 2476788-1 1989 Recent studies show that substitutions for the His in position 12 of bombesin (Bn) are important in determining antagonist activity. Histidine 47-50 gastrin releasing peptide Homo sapiens 79-81 2645047-6 1989 Both tumors were found to be mutated in the 61st N-ras codon from gln to his. Histidine 73-76 NRAS proto-oncogene, GTPase Homo sapiens 49-54 2488733-4 1989 NMR spectra also indicate a protonation of the histidine moiety by Ara-C. Histidine 47-56 p21 (RAC1) activated kinase 3 Homo sapiens 67-70 2853973-0 1988 Site-directed mutagenesis of yeast cytochrome c peroxidase shows histidine 181 is not required for oxidation of ferrocytochrome c. The long-distance electron transfer observed in the complex formed between ferrocytochrome c and compound I, the peroxide-oxidized form of cytochrome c peroxidase (CCP), has been proposed to occur through the participation of His 181 of CCP and Phe 87 of yeast iso-1 cytochrome c [Poulos, T. L., & Kraut, J. Histidine 65-74 cytochrome-c peroxidase Saccharomyces cerevisiae S288C 35-58 2853973-0 1988 Site-directed mutagenesis of yeast cytochrome c peroxidase shows histidine 181 is not required for oxidation of ferrocytochrome c. The long-distance electron transfer observed in the complex formed between ferrocytochrome c and compound I, the peroxide-oxidized form of cytochrome c peroxidase (CCP), has been proposed to occur through the participation of His 181 of CCP and Phe 87 of yeast iso-1 cytochrome c [Poulos, T. L., & Kraut, J. Histidine 65-74 cytochrome-c peroxidase Saccharomyces cerevisiae S288C 270-293 2853973-0 1988 Site-directed mutagenesis of yeast cytochrome c peroxidase shows histidine 181 is not required for oxidation of ferrocytochrome c. The long-distance electron transfer observed in the complex formed between ferrocytochrome c and compound I, the peroxide-oxidized form of cytochrome c peroxidase (CCP), has been proposed to occur through the participation of His 181 of CCP and Phe 87 of yeast iso-1 cytochrome c [Poulos, T. L., & Kraut, J. Histidine 65-74 cytochrome-c peroxidase Saccharomyces cerevisiae S288C 295-298 2853973-0 1988 Site-directed mutagenesis of yeast cytochrome c peroxidase shows histidine 181 is not required for oxidation of ferrocytochrome c. The long-distance electron transfer observed in the complex formed between ferrocytochrome c and compound I, the peroxide-oxidized form of cytochrome c peroxidase (CCP), has been proposed to occur through the participation of His 181 of CCP and Phe 87 of yeast iso-1 cytochrome c [Poulos, T. L., & Kraut, J. Histidine 65-74 cytochrome-c peroxidase Saccharomyces cerevisiae S288C 368-371 3076850-5 1988 It has been shown that human VIP is cosynthesized with PHM (peptide with N-terminal histidine and C-terminal methionine amide, the human analogue of PHI) from the same large precursor protein (Itoh et al., 1983). Histidine 84-93 peptidylglycine alpha-amidating monooxygenase Homo sapiens 55-58 2851333-0 1988 Hydration of CO2 by carbonic anhydrase: intramolecular proton transfer between Zn2+-bound H2O and histidine 64 in human carbonic anhydrase II. Histidine 98-107 carbonic anhydrase 2 Homo sapiens 120-141 2851333-1 1988 The energy barrier for the intramolecular proton transfer between zinc-bound water and His 64 in the active site of human carbonic anhydrase II (HCA II) has been studied at the partial retention of diatomic differential overlap (PRDDO) level. Histidine 87-90 carbonic anhydrase 2 Homo sapiens 122-143 2900138-6 1988 T1 is related to TC1, and has the structure: Ser-Ser(P)-Met-Ser-Gly-Leu-His-Leu-Val-Lys. Histidine 72-75 Serum cholesterol level QTL 22 Rattus norvegicus 17-20 3391168-4 1988 It was demonstrated, on the basis of the photo-CIDNP spectrum, that one of seven histidines, all three tyrosines and a single tryptophan of the rabbit soluble cytochrome b5 are exposed on the surface of the protein. Histidine 81-91 cytochrome b5 Oryctolagus cuniculus 159-172 3276685-3 1988 Using oligonucleotide-directed mutagenesis of the cloned E. coli citrate synthase gene, we prepared missense mutants, designated CS226H----Q and CS229H----Q, in which histidine residues at positions 226 and 229, respectively, were replaced by glutamine. Histidine 167-176 citrate synthase Sus scrofa 65-81 3289296-9 1988 The difference in the minimal active fragment between NMB and GRP-10 suggests that the amino acid of position 3 - NMB (Leu) and GRP-10 (His) - may play an important role in their biological activity. Histidine 136-139 neuromedin B Canis lupus familiaris 54-57 2963625-5 1988 A tyrosine/histidine polymorphism was observed within the seventh homologous repeat unit of factor H. Histidine 11-20 complement factor H Homo sapiens 92-100 2827651-1 1987 We synthesized a hexapeptide, Gly-His-His-Pro-His-Gly, previously identified as a tandem motif in the histidine-rich glycoprotein (HRG) which has multiple heme-binding sites. Histidine 38-41 histidine rich glycoprotein Homo sapiens 102-129 2827651-1 1987 We synthesized a hexapeptide, Gly-His-His-Pro-His-Gly, previously identified as a tandem motif in the histidine-rich glycoprotein (HRG) which has multiple heme-binding sites. Histidine 38-41 histidine rich glycoprotein Homo sapiens 131-134 2826144-5 1987 In unliganded methemoglobin pK1, which is associated with carboxylic acid groups, ranges between 4.0 and 5.5 for the three methemoglobins; pK2, which is associated with histidines and terminal amino groups, ranges from 6.2 to 6.7. Histidine 169-179 prokineticin 2 Homo sapiens 139-142 3478091-9 1987 It is proposed that the residue having a kinetic pKa of 5.9 is the histidine modified by diethyl pyrocarbonate and that this residue participates in general acid/base catalysis during substrate hydrolysis by neutral endopeptidase 24.11. Histidine 67-76 membrane metallo-endopeptidase Rattus norvegicus 208-235 2437111-2 1987 Bovine NRP was identified as H-Ile-Ala-Arg-Arg-His-Pro-Tyr-Phe-Leu-OH, which is similar in structure to both neurotensin and angiotensin I. Canine and human NRP also had the above amino acid composition, whereas that obtained from rat plasma had valine substituted for isoleucine. Histidine 47-50 neurotensin Bos taurus 109-120 3030432-5 1987 The function of the heme c moieties in the catalytic cycle of the enzyme is discussed on the basis of their homology with the proximal histidine region of peroxidase (horseradish peroxidase and yeast cytochrome-c peroxidase) and cytochromes (horse cytochrome c and Pseudomonas cytochrome c-551). Histidine 135-144 cytochrome-c peroxidase Saccharomyces cerevisiae S288C 200-223 3813569-2 1987 One of the histidine C-2 peaks titrated normally, with a pKa value of 6.8, but the other two histidines in this peptide had pKa values of 6.3. Histidine 11-20 complement C2 Bos taurus 21-24 3813569-3 1987 Denatured PTH showed only one histidine C-2 peak with a pKa of 6.7. Histidine 30-39 parathyroid hormone Bos taurus 10-13 3095115-7 1986 Like human apo A-I, rabbit apo A-I contains very little histidine (2) and methionine (1); it does however have two residues of isoleucine. Histidine 56-65 apolipoprotein A-I Oryctolagus cuniculus 27-34 3098281-1 1986 Two model peptides Boc-Asp-Pro-Aib-X-NHMe [X = His (1) and X = Lys (2)] were synthesized to simulate intramolecular electrostatic interactions between ionizable side chains. Histidine 47-50 ANIB1 Homo sapiens 31-34 2421767-2 1986 Anti-fibrin antibody 59D8 which had been elicited by immunization with human beta(1-7) peptide, Gly-His-Arg-Pro-Leu-Asp-Lys, binds to human and canine fibrins but not to bovine, ovine, or porcine fibrins. Histidine 100-103 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Homo sapiens 77-85 3877728-10 1985 The unique N-terminal amino acid sequences of both forms of CSF were the same: (Lys-Glu-Val-Ser-Glu-His-X-Ser-His-Met-Ile-Gly-Asn). Histidine 100-103 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 60-63 3877728-10 1985 The unique N-terminal amino acid sequences of both forms of CSF were the same: (Lys-Glu-Val-Ser-Glu-His-X-Ser-His-Met-Ile-Gly-Asn). Histidine 110-113 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 60-63 2415656-8 1985 This binding site involves some of the same amino acid side chains, His 435, Tyr 436, and one or both His 433 and 310, and is in the same location as the site that binds SPA. Histidine 68-71 surfactant protein A2 Homo sapiens 170-173 2415656-8 1985 This binding site involves some of the same amino acid side chains, His 435, Tyr 436, and one or both His 433 and 310, and is in the same location as the site that binds SPA. Histidine 102-105 surfactant protein A2 Homo sapiens 170-173 3878728-10 1985 The resonances for the C2-H protons of His-67 and His-72, which exist in the C3a part of the human C3 molecule, were assigned. Histidine 39-42 complement C3 Homo sapiens 77-80 3878728-10 1985 The resonances for the C2-H protons of His-67 and His-72, which exist in the C3a part of the human C3 molecule, were assigned. Histidine 50-53 complement C3 Homo sapiens 77-80 3840230-9 1985 Each of these regions contains the presumed active site sequence Trp-Cys-Gly-His-Cys-Lys, suggesting that PDI, similar in action to thioredoxin, catalyses disulphide bond interchange via an internal disulphide-sulphydryl interchange. Histidine 77-80 prolyl 4-hydroxylase subunit beta Rattus norvegicus 106-109 3841693-4 1985 The data support the following prerequisites for the maximal neuromodulatory role of bombesin-like peptides on gastric secretion: Trp is required at position 8; Gln and His are important at positions 7 and 12, respectively; Leu replacement by Phe, which occurs in the litorin subfamily, modifies the response; and unspecified amino acids or sequences are also involved in the N-terminal region of bombesin-like peptides. Histidine 169-172 gastrin releasing peptide Homo sapiens 85-93 3920737-5 1985 Cyclo(His-Pro) concentrations in the whole brain were significantly greater in the LPD group than in the pair-fed and ad libitum groups, whereas its concentrations were similar in the pair-fed and ad libitum groups. Histidine 6-9 acyl-CoA synthetase bubblegum family member 1 Rattus norvegicus 83-86 6525172-1 1984 Chemical modification of amino acid residues with phenylglyoxal, N-ethylmaleimide and diethyl pyrocarbonate indicated that at least one residue each of arginine, cysteine and histidine were essential for the activity of sheep liver serine hydroxymethyltransferase. Histidine 175-184 serine hydroxymethyltransferase, cytosolic Ovis aries 232-263 6470009-1 1984 Two different methods were used to determine the number of Bohr protons released upon oxygenation of human hemoglobin (Hb A) and Hb A lacking beta 146 His (des-His Hb A) at the pH ranging from pH 5.0 to 9.0 in the presence of 0.1 M Cl- at 25 degrees C. One is the direct differential titration method, the other is based on the measurement of oxygen affinity as a function of pH. Histidine 151-154 sodium voltage-gated channel alpha subunit 2 Homo sapiens 129-133 6470009-1 1984 Two different methods were used to determine the number of Bohr protons released upon oxygenation of human hemoglobin (Hb A) and Hb A lacking beta 146 His (des-His Hb A) at the pH ranging from pH 5.0 to 9.0 in the presence of 0.1 M Cl- at 25 degrees C. One is the direct differential titration method, the other is based on the measurement of oxygen affinity as a function of pH. Histidine 151-154 sodium voltage-gated channel alpha subunit 2 Homo sapiens 129-133 6470009-8 1984 105, 353-360), it became evident that almost all (about 92%) of the alkaline Bohr protons released upon oxygenation of Hb A in the presence of 0.1 M Cl- could be accounted for by the protons from these 2 residues, although the involvement of other histidine residues could not be denied. Histidine 248-257 sodium voltage-gated channel alpha subunit 2 Homo sapiens 119-123 6470009-9 1984 About half the acid Bohr protons from Hb A, which corresponds to the higher pH part (above pH 5.0) of the acid Bohr effect, could be explained by the involvement of beta 143 His residue. Histidine 174-177 sodium voltage-gated channel alpha subunit 2 Homo sapiens 38-42 6202883-2 1984 DNA sequence analysis of the glycoprotein D gene of the isolate revealed a single nucleotide alteration which changed the codon for asparagine to one encoding histidine at amino acid 97 in the protein. Histidine 159-168 atypical chemokine receptor 1 (Duffy blood group) Homo sapiens 29-43 6725279-9 1984 beta-Thrombin was observed to undergo modification at the active site histidine at a slower rate than that of alpha-thrombin when reacted with either tosyllysyl chloromethyl ketone or diethyl pyrocarbonate. Histidine 70-79 coagulation factor II, thrombin Bos taurus 5-13 6725279-10 1984 It is suggested that the difference in the fibrinogen-clotting activity of these two forms of thrombin can result from changes in the reactivity of the active site histidine residue. Histidine 164-173 coagulation factor II, thrombin Bos taurus 94-102 6320014-3 1984 Tonin can produce directly the vasoactive peptide angiotensin II, from angiotensin I, angiotensinogen and the synthetic tetradecapeptide substrate of renin by cleavage of a Phe-His bond. Histidine 177-180 kallikrein 1-related peptidase C2 Rattus norvegicus 0-5 6626566-10 1983 Preincubation with p-bromophenacyl bromide inhibited phospholipase A2, suggesting the presence of histidine at the active site. Histidine 98-107 phospholipase A2, group IB, pancreas Mus musculus 53-69 6194822-2 1983 Residues 67 to 75 in myelin basic protein from several species comprise the sequence Thr-His-Tyr-Gly-Ser-Leu-Pro-Gln-Lys that acts as an encephalitogenic determinant in the rabbit. Histidine 89-92 myelin basic protein Oryctolagus cuniculus 21-41 6574481-4 1983 In the presence of Leu-tRNA or His-tRNA, the tripeptides fMet-Val-Leu and fMet-Val-His are synthesized, corresponding to the NH2-terminal sequence of alpha- and beta-globin, respectively. Histidine 31-34 hemoglobin subunit beta-1/2 Oryctolagus cuniculus 150-172 6574481-4 1983 In the presence of Leu-tRNA or His-tRNA, the tripeptides fMet-Val-Leu and fMet-Val-His are synthesized, corresponding to the NH2-terminal sequence of alpha- and beta-globin, respectively. Histidine 83-86 hemoglobin subunit beta-1/2 Oryctolagus cuniculus 150-172 6136484-7 1983 These findings point to the severe impairment of histidase and urocanase, two enzymes regulating the histidine catabolic pathway. Histidine 101-110 histidine ammonia-lyase Homo sapiens 49-58 6281785-1 1982 alpha-Melanocyte-stimulating hormone (alpha-melanotropin; alpha-MSH) is a linear tridecapeptide (Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2) that reversibly darkens amphibian skins by stimulating melanomsome (pigment granule) dispersion within melanophores. Histidine 120-123 msh homeobox 1 Mus musculus 64-67 6913406-7 1981 The modified amino acid was identified as pi - (carboxymethyl)histidine, which establishes that His-66 is at or near the AA-tRNA binding site on EF-Tu.GTP. Histidine 96-99 eukaryotic translation elongation factor, selenocysteine-specific Drosophila melanogaster 145-150 7211776-1 1981 A highly specific and sensitive procedure for determining histidase activity, with labeled histidine as the substrate, that requires only 1 to 2 mg of stratum corneum epidermidis has been developed. Histidine 91-100 histidine ammonia-lyase Homo sapiens 58-67 7213621-7 1981 the catalytic role of glyoxalase II appears to involve direct nucleophilic attack of the thiol ester by an active-site histidine residue, based upon inactivation experiments using diethyl pyrocarbonate and photoinactivation with methylene blue. Histidine 119-128 hydroxyacyl glutathione hydrolase Rattus norvegicus 22-35 6260763-9 1981 The pKa for His-91 was shifted to the alkaline side in the presence of 3"-GMP, a competitive inhibitor, in the titration plots observed by both hydrogen-tritium exchange and 1H NMR spectroscopy. Histidine 12-15 5'-nucleotidase, cytosolic II Homo sapiens 74-77 6260763-10 1981 The 31P NMR titration data suggest that in the 3"-GMP-RNase St complex the dianion form of the nucleotide participates in the interaction with the protonated form of His-91. Histidine 166-169 5'-nucleotidase, cytosolic II Homo sapiens 50-53 7356971-7 1980 The pH profile suggests the participation of a protonated enzyme group(s) (pK = 7.2-7.5) in NADPH binding, probably a histidine residue. Histidine 118-127 2,4-dienoyl-CoA reductase 1 Homo sapiens 92-97 6164144-1 1980 The histidine metabolism in homogenates of human tissues of nontreated benign prostatic hyperplasia has been examined by means of the determination of L-histidine ammonia lyase activity (EC 4.3.1.3;histidine alpha-deaminase, histidase) and the histidine imidazole metabolites which were separated by means of ion exchange chromatography. Histidine 4-13 histidine ammonia-lyase Homo sapiens 153-176 393248-0 1979 The exchange of histidine C-2 protons in superoxide dismutases. Histidine 16-25 complement C2 Bos taurus 26-29 393248-2 1979 The rates of exchange of the C-2 protons of histidine residues in copper-zinc superoxide dismutase are substantially decreased by metal ion binding. Histidine 44-53 complement C2 Bos taurus 29-32 31898-1 1978 Proton magnetic resonance pH titration studies of the two histidines of bovine chymotrypsinogen A and chymotrypsin Aalpha. Histidine 58-68 chymotrypsinogen A Bos taurus 79-121 360048-6 1978 The use of diethyl pyrocarbonate indicates the participation also of histidine in fibrinogen-thrombin interactions and that, whereas the histidine residues of the Bbeta chain are involved to a great extent, it appears that those of the Aalpha chain are not. Histidine 69-78 coagulation factor II, thrombin Bos taurus 93-101 886385-0 1977 Effect of histidine intake and hepatic histidase activity on the metabolism of histidine in vivo. Histidine 79-88 histidine ammonia-lyase Homo sapiens 39-48 405036-0 1977 Histidine-200 alters inhibitor binding in human carbonic anhydrase B. Histidine 0-9 carbonic anhydrase 2 Homo sapiens 48-68 870089-4 1977 However, the rat muscle glyceraldehyde-3-phosphate dehydrogenase is characterised by a markedly lower histidine content. Histidine 102-111 glyceraldehyde-3-phosphate dehydrogenase Rattus norvegicus 24-64 265581-3 1977 The amino acid sequence analysis of tryptic peptide 17" of protein A24: (see text) showed it contains tryptic peptide 17 of histone 2A, Lys-Thr-Glu-Ser-His-His-Lys. Histidine 152-155 immunoglobulin kappa variable 2-23 (pseudogene) Homo sapiens 67-70 265581-3 1977 The amino acid sequence analysis of tryptic peptide 17" of protein A24: (see text) showed it contains tryptic peptide 17 of histone 2A, Lys-Thr-Glu-Ser-His-His-Lys. Histidine 156-159 immunoglobulin kappa variable 2-23 (pseudogene) Homo sapiens 67-70 833672-11 1977 Offspring from gilts fed the histidine-free diet had lower blood hemoglobin concentrations than their counterparts from gilts receiving histidine. Histidine 29-38 HGB Sus scrofa 65-75 993333-3 1976 Glutamine B10 and histidine E7 (the distal histidine) swing towards each other and, between them, stabilize a water molecule in the normally hydrophobic heme pocket. Histidine 43-52 ectonucleotide pyrophosphatase/phosphodiesterase 3 Homo sapiens 10-13 976263-3 1976 The alkylation of a histidine residue which is fast and extensive when the alkylation side chain is on the C-3 carbon atom, is dramatically decreased when alkylating side chain is shifted towards rings B and D. These results allow the location of this histidine in the vicinity of ring A and probably on the beta face of the steroid nucleus. Histidine 20-29 complement C3 Homo sapiens 107-110 976263-3 1976 The alkylation of a histidine residue which is fast and extensive when the alkylation side chain is on the C-3 carbon atom, is dramatically decreased when alkylating side chain is shifted towards rings B and D. These results allow the location of this histidine in the vicinity of ring A and probably on the beta face of the steroid nucleus. Histidine 252-261 complement C3 Homo sapiens 107-110 8090-0 1976 pH dependence of tritium exchange with the C-2 protons of the histidines in bovine trypsin. Histidine 62-72 complement C2 Bos taurus 43-46 8090-1 1976 At pH 8.9 and 37 degrees C the half-times for tritium exchange with the C-2 protons of the histidines of trypsin are 73 days for His-57, and greater than 1000 days for His-40 and His-91. Histidine 91-101 complement C2 Bos taurus 72-75 8090-1 1976 At pH 8.9 and 37 degrees C the half-times for tritium exchange with the C-2 protons of the histidines of trypsin are 73 days for His-57, and greater than 1000 days for His-40 and His-91. Histidine 129-132 complement C2 Bos taurus 72-75 8090-1 1976 At pH 8.9 and 37 degrees C the half-times for tritium exchange with the C-2 protons of the histidines of trypsin are 73 days for His-57, and greater than 1000 days for His-40 and His-91. Histidine 168-171 complement C2 Bos taurus 72-75 8090-1 1976 At pH 8.9 and 37 degrees C the half-times for tritium exchange with the C-2 protons of the histidines of trypsin are 73 days for His-57, and greater than 1000 days for His-40 and His-91. Histidine 168-171 complement C2 Bos taurus 72-75 8090-2 1976 These half-times are much longer than the half-life of exchange for the C-2 proton of free histidine (2.8 days at pD 8.2), and longer than any previously reported half-time of exchange at pH greater than 8. Histidine 91-100 complement C2 Bos taurus 72-75 944591-14 1976 Inhibition by the active-site-histidine-modifying inhibitor, N-alpha-p-tosyl-L-arginine chloromethyl ketone, was enhanced by the addition of prothrombin fragment 2. Histidine 30-39 coagulation factor II, thrombin Bos taurus 141-152 1201380-4 1975 3 Both the tryptophan and histidine residues seemed to be essential for bombesin-like activity. Histidine 26-35 gastrin releasing peptide Homo sapiens 72-80 1168484-8 1975 It is suggested that, in addition to reaction with tyrosine, there is a reaction of N-butyrylimidazole with either the histidine and/or serine residue at the active site of thrombin resulting in a derivative unstable under esterase assay conditions such as that described for the reaciton of N-acetylimidazole with trypsin (L. L. Houston and K. A. Walsh (1970), Biochemistry 9, 156). Histidine 119-128 coagulation factor II, thrombin Bos taurus 173-181 788422-0 1975 [Histidine tolerance in low skin histidase activity]. Histidine 1-10 histidine ammonia-lyase Homo sapiens 33-42 24419545-5 1974 As well as lysine, the content of other amino acids, such as aspartic acid, arginine, glycine, threonine, valine and histidine are also, in general, increased by the presence of the o 2 gene in recessive homozygous condition.The results obtained have shown that a number of correlation coefficients between the protein quality traits and yield components related to kernel characteristics are negative and significant, especially in the presence of the o 2 gene in recessive homozygous condition. Histidine 117-126 regulatory protein opaque-2 Zea mays 182-185 4343380-0 1972 The histidines in liver alcohol dehydrogenase. Histidine 4-14 aldo-keto reductase family 1 member A1 Homo sapiens 24-45 13863215-1 1962 A deficiency in histidase resulting in the urinary excretion of histidine and of imidazolepyruvic acid. Histidine 64-73 histidine ammonia-lyase Homo sapiens 16-25 13845398-0 1959 Effect of sarcoma RD3 on intestinal active absorption of glucose and L-histidine. Histidine 69-80 RD3 regulator of GUCY2D Homo sapiens 18-21 33965786-4 2021 A C-terminal histidine-tagged version of zebrafish Prss 59.1 was constructed. Histidine 13-22 serine protease 59, tandem duplicate 1 Danio rerio 51-60 33686575-7 2021 In particular primitive fish TTR has an extremely high zinc content, with an increased number of histidine residues which are involved in TH binding. Histidine 97-106 transthyretin Homo sapiens 29-32 34032009-0 2021 beta-Actin Peptide-Based Inhibitors of Histidine Methyltransferase SETD3. Histidine 39-48 POTE ankyrin domain family member F Homo sapiens 0-10 34032009-1 2021 SETD3 was recently identified as the histidine methyltransferase responsible for N 3 -methylation of His73 of beta-actin in humans. Histidine 37-46 POTE ankyrin domain family member F Homo sapiens 110-120 33563959-6 2021 Our results establish METTL9-mediated 1MH as a pervasive protein modification, thus setting the stage for further functional studies on protein histidine methylation. Histidine 144-153 methyltransferase like 9 Homo sapiens 22-28 32671530-8 2021 ICA reversed the HI-induced reduction in phosphorylated Akt and activation of cleaved caspase-3. Histidine 17-19 caspase 3 Mus musculus 86-95 33398979-8 2020 After purification by nickel affinity column, the fusion protein His-TIMP-2 was identified by Western blotting method and its biological activity was detected by gelatin zymography. Histidine 65-68 TIMP metallopeptidase inhibitor 2 Homo sapiens 69-75 32780163-7 2020 We show that TAT1 suppression occurs through replenishment of the GTP pool in a process requiring the histidine biosynthesis pathway. Histidine 102-111 amino acid transporter TAT1 Saccharomyces cerevisiae S288C 13-17 33096938-7 2020 The CXCR4 protein used in this assay was produced with a C-terminal 10x-histidine tag and was immobilized on a nitrilotriacetic acid chip. Histidine 72-81 C-X-C motif chemokine receptor 4 Homo sapiens 4-9 33025907-0 2020 Feedback control of Wnt signaling based on ultrastable histidine cluster co-aggregation between Naked/NKD and Axin. Histidine 55-64 axin 1 Homo sapiens 110-114 33025907-6 2020 Naked/NKD HisC cores co-aggregate with a conserved histidine cluster within Axin, to destabilize it along with Dishevelled, possibly via the autophagy receptor p62 which binds to HisC aggregates. Histidine 51-60 axin 1 Homo sapiens 76-80 33025907-6 2020 Naked/NKD HisC cores co-aggregate with a conserved histidine cluster within Axin, to destabilize it along with Dishevelled, possibly via the autophagy receptor p62 which binds to HisC aggregates. Histidine 51-60 nucleoporin 62 Homo sapiens 160-163 33000155-5 2020 Excess histidine may be converted to trans-urocanate by histidine ammonia lyase (histidase) in liver and skin. Histidine 7-16 histidine ammonia-lyase Homo sapiens 56-79 33000155-5 2020 Excess histidine may be converted to trans-urocanate by histidine ammonia lyase (histidase) in liver and skin. Histidine 7-16 histidine ammonia-lyase Homo sapiens 81-90 32962355-4 2020 As a cysteine protease, PLpro is rich in cysteines and histidines, and their protonation/deprotonation modulates catalysis and conformational plasticity. Histidine 55-65 cathepsin B Homo sapiens 5-22 32046993-3 2020 OBJECTIVE: We report the clinical experience and physician evaluation of this new detector system with Hi-Def mode for the treatment of intracranial aneurysms using a Pipeline embolization device (PED). Histidine 103-105 UTP25 small subunit processome component Homo sapiens 106-109 32787066-1 2020 The histidine-rich antimicrobial peptides (AMPs) Gad-1 and Gad-2, from paralogous genes in cod, provide an opportunity to examine the effect of charge and non-electrostatic factors on peptide-vesicle interaction and on peptide antimicrobial activity. Histidine 4-13 glutamate decarboxylase 1 Homo sapiens 49-54 32448098-8 2021 The major hot spot amino acids involved in the binding identified by interaction analysis after simulations includes Glu 35, Tyr 83, Asp 38, Lys 31, Glu 37, His 34 amino acid residues of ACE2 receptor and Gln 493, Gln 498, Asn 487, Tyr 505 and Lys 417 residues in nCoV S-protein RBD. Histidine 157-160 vitronectin Homo sapiens 269-278 32181671-0 2020 Molecular Dynamics Simulations Based on Newly Developed Force Field Parameters for Cu2+ Spin Labels Provide Insights Into Double Histidine-Based Double Electron-Electron Resonance. Histidine 129-138 spindlin 1 Homo sapiens 88-92 32181671-1 2020 Electron paramagnetic resonance (EPR) in combination with the recently developed double Histidine (dHis) based Cu(II) spin labeling has provided valuable insights into protein structure and conformational dynamics. Histidine 88-97 spindlin 1 Homo sapiens 118-122 32392205-5 2020 The differential specificity of ligands to BLT1 and BLT2 is explained by the replacement of histidine with tyrosine. Histidine 92-101 leukotriene B4 receptor Homo sapiens 43-47 32392205-6 2020 In BLT1, the histidine residue binds the 5-OH group of the ligand, while the tyrosine residue in BLT2 repels it. Histidine 13-22 leukotriene B4 receptor Homo sapiens 3-7 31348608-3 2020 The lysine-arginine-ornithine binding protein (LAO) is a PBP of 238 residues that binds the basic amino acids l-arginine and l-histidine with nm and mum affinity, respectively. Histidine 125-136 phosphatidylethanolamine binding protein 1 Homo sapiens 57-60 33390398-8 2020 The mRNA levels of PPARgamma, LXRalpha, and AMPKalpha in the liver were also reduced by excess histidine intake. Histidine 95-104 peroxisome proliferator-activated receptor gamma Rattus norvegicus 19-28 31644276-6 2019 Also, the role of a histidine residue in the AQP4 channel was identified by alchemical transformation and umbrella sampling methods. Histidine 20-29 aquaporin 4 Mus musculus 45-49 31757046-0 2019 Probing the Interactions of Sulfur-Containing Histidine Compounds with Human Gamma-Glutamyl Transpeptidase. Histidine 46-55 inactive glutathione hydrolase 2 Homo sapiens 77-106 31273981-9 2019 Analysis of a peptide maquette derived from the N-terminus of HypA revealed that nickel is predominately coordinated by atoms from the N-terminal Met-His motif. Histidine 150-153 hypA Escherichia coli 62-66 31375562-0 2019 Sulfur-containing histidine compounds inhibit gamma-glutamyl transpeptidase activity in human cancer cells. Histidine 18-27 inactive glutathione hydrolase 2 Homo sapiens 46-75 31254495-1 2019 PHT2, a member of the proton-coupled oligopeptide transporter family, participates in the transportation of small peptides and histidine from lysosomes to the cytosol. Histidine 127-136 solute carrier family 15 member 3 Homo sapiens 0-4 30937958-3 2019 We found that an HSL protein with a His-tag at the N-terminus preserved the normal hydrolase activity of cholesteryl ester (CE) but the triglyceride lipase (TG) activity significantly decreased in vitro. Histidine 36-39 lipase, hormone sensitive Mus musculus 17-20 30937958-6 2019 To compare His-HSL and wild-type HSL in vitro and in vivo, we confirmed that the His-tag significantly suppressed HSL TG activity. Histidine 11-14 lipase, hormone sensitive Mus musculus 15-18 31366154-4 2019 Genetically programming sGFP and RFP with Cys-tag and His-tag, respectively, allowed tuning the protein spatial organization either across the porous structure of two microbeads with different functional groups (agarose-based materials activated with metal chelates and epoxy-methacrylate materials) or across the surface of a single microbead functionalized with both metal-chelates and disulfide groups. Histidine 54-57 tripartite motif containing 27 Homo sapiens 33-36 31344907-7 2019 Spectroscopic data confirmed that AtLRB3 contains a histidine-ligated heme cofactor and importantly, the addition of NO to AtLRB3 yielded absorption characteristics reminiscent of canonical H-NOX proteins. Histidine 52-61 BTB/POZ/Kelch-associated protein Arabidopsis thaliana 34-40 31537250-7 2019 The purified recombinant His-RBP was used to immunize New Zealand white rabbits. Histidine 25-28 retinol binding protein 4 Homo sapiens 29-32 31164399-0 2019 The histidine-rich loop in the extracellular domain of ZIP4 binds zinc and plays a role in zinc transport. Histidine 4-13 solute carrier family 39 member 4 Homo sapiens 55-59 31164399-4 2019 In this work, we examined zinc binding to the isolated ZIP4-ECD from Pteropus Alecto (black fruit bat) and located zinc-binding sites with a low micromolar affinity within a histidine-rich loop ubiquitously present in ZIP4 proteins. Histidine 174-183 solute carrier family 39 member 4 Homo sapiens 55-59 31164399-4 2019 In this work, we examined zinc binding to the isolated ZIP4-ECD from Pteropus Alecto (black fruit bat) and located zinc-binding sites with a low micromolar affinity within a histidine-rich loop ubiquitously present in ZIP4 proteins. Histidine 174-183 solute carrier family 39 member 4 Homo sapiens 218-222 31164399-6 2019 Mutagenesis and functional study on human ZIP4 by using an improved cell-based zinc uptake assay indicated that the histidine residues within this loop are not involved in preselection of metal substrate but play a role in promoting zinc transport. Histidine 116-125 solute carrier family 39 member 4 Homo sapiens 42-46 31000629-6 2019 Here we used RNA chemical footprinting and binding assays to test this model and further probe the molecular basis for the requirement for two critical tRNA-interacting residues, His-152 and Lys-187, in the context of human Thg1 (hThg1). Histidine 179-182 tRNA-histidine guanylyltransferase 1 like Homo sapiens 224-228 31000629-6 2019 Here we used RNA chemical footprinting and binding assays to test this model and further probe the molecular basis for the requirement for two critical tRNA-interacting residues, His-152 and Lys-187, in the context of human Thg1 (hThg1). Histidine 179-182 tRNA-histidine guanylyltransferase 1 like Homo sapiens 230-235 31142756-5 2019 SK-N-SH neuronal cells were exposed to active recombinant histidine-tagged cathepsin B (His-CATB). Histidine 58-67 cathepsin B Homo sapiens 75-86 31142756-5 2019 SK-N-SH neuronal cells were exposed to active recombinant histidine-tagged cathepsin B (His-CATB). Histidine 58-67 cathepsin B Homo sapiens 92-96 31142756-10 2019 Neurons exposed to macrophage-conditioned media differentially internalized His-CATB, dependent on the HIV replication levels. Histidine 76-79 cathepsin B Homo sapiens 80-84 30626284-6 2019 These data, together with molecular dynamics studies, indicate that the histidine is highly flexible, even when complexed with BECN1 BH3. Histidine 72-81 beclin 1 Homo sapiens 127-132 30879301-3 2019 Our chemogenetic experiments demonstrate that the highly conserved cysteine and histidine residues within the C-X8-C-X24-75-H-X-G-G-H motif of the TLF domain of Apd1 and Aim32 proteins are essential for viability of yeast cells upon treatment with the redox mediators gallobenzophenone or pyrogallol, respectively. Histidine 80-89 Apd1p Saccharomyces cerevisiae S288C 161-165 30879301-3 2019 Our chemogenetic experiments demonstrate that the highly conserved cysteine and histidine residues within the C-X8-C-X24-75-H-X-G-G-H motif of the TLF domain of Apd1 and Aim32 proteins are essential for viability of yeast cells upon treatment with the redox mediators gallobenzophenone or pyrogallol, respectively. Histidine 80-89 Aim32p Saccharomyces cerevisiae S288C 170-175 30879301-6 2019 Apd1 and its engineered variants represent an unprecedented flexible system for which a stable [2Fe-2S] cluster with two histidine ligands, (two different) single histidine ligands, or only cysteinyl ligands is possible in the same protein fold. Histidine 121-130 Apd1p Saccharomyces cerevisiae S288C 0-4 30879301-6 2019 Apd1 and its engineered variants represent an unprecedented flexible system for which a stable [2Fe-2S] cluster with two histidine ligands, (two different) single histidine ligands, or only cysteinyl ligands is possible in the same protein fold. Histidine 163-172 Apd1p Saccharomyces cerevisiae S288C 0-4 30969963-2 2019 Here we determined the evolutionarily-relevant segment of the fitness landscape of His3, a gene coding for an enzyme in the histidine synthesis pathway, focusing on combinations of amino acid states found at orthologous sites of extant species. Histidine 124-133 imidazoleglycerol-phosphate dehydratase HIS3 Saccharomyces cerevisiae S288C 83-87 30804004-6 2019 This study suggests that perturbations in histidine metabolism selectively target neural tumours that grow via a dedifferentiation process involving large cell size increases driven by Myc. Histidine 42-51 Myc Drosophila melanogaster 185-188 30902068-8 2019 The resulting Dr-dUTPase had the leading peptide Gly-Ser-His- originating from the vector at the amino terminus, and a mutation, Arg66Lys, to remove the internal thrombin site. Histidine 57-60 Deoxyuridine triphosphatase Drosophila melanogaster 17-24 30785395-0 2019 Structural insights into SETD3-mediated histidine methylation on beta-actin. Histidine 40-49 POTE ankyrin domain family member F Homo sapiens 65-75 30278216-0 2019 Ligand chirality can affect histidine protonation of vitamin-D receptor: ab initio molecular orbital calculations in water. Histidine 28-37 vitamin D receptor Homo sapiens 53-71 30278216-6 2019 The FMO results reveal that two histidine residues of VDR contribute significantly to the binding between VDR and ligand and that their protonation states can affect the specific interactions between VDR and ligand. Histidine 32-41 vitamin D receptor Homo sapiens 54-57 30278216-6 2019 The FMO results reveal that two histidine residues of VDR contribute significantly to the binding between VDR and ligand and that their protonation states can affect the specific interactions between VDR and ligand. Histidine 32-41 vitamin D receptor Homo sapiens 106-109 30278216-6 2019 The FMO results reveal that two histidine residues of VDR contribute significantly to the binding between VDR and ligand and that their protonation states can affect the specific interactions between VDR and ligand. Histidine 32-41 vitamin D receptor Homo sapiens 106-109 30278216-8 2019 The results illustrate the possibility that the difference in the chirality of a ligand can induce the change in protonation states of the histidine residues of VDR existing near the ligand. Histidine 139-148 vitamin D receptor Homo sapiens 161-164 30287244-3 2019 All members share a common catalytic mechanism, which involves a conserved catalytic triad, constituted by two histidines and a lysine (His15/His122/Lys38 in RNase6 corresponding to His12/His119/Lys41 in RNaseA). Histidine 111-121 ribonuclease A family member k6 Homo sapiens 158-164 30287244-4 2019 Recently, our first crystal structure of human RNase6 identified an additional His pair (His36/His39) and suggested the presence of a secondary active site. Histidine 79-82 ribonuclease A family member k6 Homo sapiens 47-53 30171712-5 2019 Site Finder and molecular docking defined the thiazolidinones interactions with the most important catalytic residues of DNase I, including the H-acceptor interaction with residues His 134 and His 252 and/or H-donor interaction with residues Glu 39 and Asp 168. Histidine 181-184 deoxyribonuclease 1 Rattus norvegicus 121-128 30171712-5 2019 Site Finder and molecular docking defined the thiazolidinones interactions with the most important catalytic residues of DNase I, including the H-acceptor interaction with residues His 134 and His 252 and/or H-donor interaction with residues Glu 39 and Asp 168. Histidine 193-196 deoxyribonuclease 1 Rattus norvegicus 121-128 30604175-6 2019 Of those AtELOs, AtELO1 and AtELO2 had a characteristic histidine motif and were bound to AtCb5-B. Histidine 56-65 Paxneb protein-like protein Arabidopsis thaliana 17-23 30408622-6 2018 Meanwhile, mannitol, a ROS scavenger, could not protect against dissociation, which implied that local ROS from accessible histidine residues may be crucially beneficial to the formation of mCRP in a redox-balanced microenvironment. Histidine 123-132 C-reactive protein, pentraxin-related Mus musculus 190-194 30474742-0 2018 Expression, purification, and evaluation of in vivo anti-fibrotic activity for soluble truncated TGF-beta receptor II as a cleavable His-SUMO fusion protein. Histidine 133-136 transforming growth factor, beta receptor II Mus musculus 97-117 30345437-5 2018 Indeed, in addition to the three-coordinated species containing one His ligand, a N-terminal amine group and the carboxylate side chain of the Asp1 residue of Abeta already proposed, we found two other Cu-Abeta coordination modes involving two histidines. Histidine 244-254 beta-secretase 2 Homo sapiens 143-147 30335580-1 2018 Carnosine and anserine are dipeptides synthesized from histidine and beta-alanine by carnosine synthase (ATPGD1). Histidine 55-64 carnosine synthase 1 Homo sapiens 105-111 30337625-3 2018 The results showed that, compared with six commercial plasmids, pHH-GM1 significantly enhanced His-HA-ALPK1 expression in a western blot analysis of transfected HEK293T cells. Histidine 95-98 alpha kinase 1 Homo sapiens 102-107 30230320-3 2018 Here, we characterized the structural features of histidines in the chemokines CXCL8 and CXCL1 in the free, GAG heparin-bound, and CXCR2 receptor N-terminal domain-bound states using solution NMR spectroscopy. Histidine 50-60 C-X-C motif chemokine ligand 1 Homo sapiens 89-94 30230320-4 2018 CXCL8 and CXCL1 share two conserved histidines, one in the N-loop and the other in the 30s loop. Histidine 36-46 C-X-C motif chemokine ligand 1 Homo sapiens 10-15 30230320-6 2018 On the other hand, in unliganded CXCL1, each of the two histidines exists in two states, as the neutral Nepsilon2 tautomer and charged imidazolium. Histidine 56-66 C-X-C motif chemokine ligand 1 Homo sapiens 33-38 29499210-9 2018 The N-terminal histidine-rich segment may be essential for neo-functionalization (i.e., high-affinity T3 binding activity) of an ancient TTR after gene duplication. Histidine 15-24 transthyretin Homo sapiens 137-140 29773582-6 2018 In isolated endothelial cells, apelin caused an increase in 4,5-diaminofluorescein fluorescence that was abolished by nitro-l-arginine (NLA) and F13A (H-Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Ala-OH), an APJ receptor antagonist, consistent with increased nitric oxide (NO) production. Histidine 177-180 apelin Rattus norvegicus 31-37 29653252-1 2018 The replacement of two consecutive histidine residues by alanine residues in the catalytic center of ceramide synthase 2 in a new transgenic mouse mutant (CerS2 H/A) leads to inactivation of catalytic activity and reduces protein level to 60% of the WT level. Histidine 35-44 ceramide synthase 2 Mus musculus 101-120 29653252-1 2018 The replacement of two consecutive histidine residues by alanine residues in the catalytic center of ceramide synthase 2 in a new transgenic mouse mutant (CerS2 H/A) leads to inactivation of catalytic activity and reduces protein level to 60% of the WT level. Histidine 35-44 ceramide synthase 2 Mus musculus 155-160 29764940-10 2018 The revised two-base catalytic mechanism may involve His-125 (Glu-134 in GNE), as suggested by mutant activity analysis. Histidine 53-56 glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase Homo sapiens 73-76 29661936-8 2018 Substitutions in the Cat domain affecting substrate specificity revealed that residues Phe-634, His-661, and Gly-671 in the S1-binding pocket of this domain are important for Ssy5 catalytic function. Histidine 96-99 Ssy5p Saccharomyces cerevisiae S288C 175-179 29795045-6 2018 The residue that plays a major role in determining the diverse pKa values of the proton shuttle is the one in position four, namely His for hCA II and Gly for hCA VII. Histidine 132-135 carbonic anhydrase 2 Homo sapiens 140-146 29795045-8 2018 These findings are in agreement with our previous studies that highlighted the importance of histidines on the protein surface of hCA II (among which His4) as crucial residues for the high catalytic efficiency of this isoform. Histidine 93-103 carbonic anhydrase 2 Homo sapiens 130-136 30277418-0 2018 Hb Hubei [alpha114(GH2)Pro His, HBA1: c.344C>A]: A Novel Hemoglobin Variant of the alpha1-Globin Chain. Histidine 27-30 growth hormone 2 Homo sapiens 19-22 30277418-1 2018 We report here a novel alpha1-globin chain variant, Hb Hubei [alpha114(GH2)Pro His, HBA1: c.344C>A], in a Chinese individual. Histidine 79-82 growth hormone 2 Homo sapiens 71-74 29584404-5 2018 These advantages are demonstrated with the measurements of binding of acetazolamide (222.2 Da) to histidine-tagged human carbonic anhydrase II (his-tagged HCA). Histidine 98-107 carbonic anhydrase 2 Homo sapiens 121-142 29176272-8 2018 This inverse correlation was more evident among the ADH1B His/His + ALDH2 Glu/Lys or Lys/Lys groups (-3.24 mg/dL, 95% CI, -5.03 to -1.45). Histidine 58-61 alcohol dehydrogenase 1B (class I), beta polypeptide Homo sapiens 52-57 29176272-8 2018 This inverse correlation was more evident among the ADH1B His/His + ALDH2 Glu/Lys or Lys/Lys groups (-3.24 mg/dL, 95% CI, -5.03 to -1.45). Histidine 62-65 alcohol dehydrogenase 1B (class I), beta polypeptide Homo sapiens 52-57 29565811-5 2018 Biochemical analyses demonstrated that UK114 hydrolyzes alpha-imino acids generated by l- or d-amino acid oxidases with a preference for those deriving from Ala > Leu = l-Met > l-Gln, whereas it was poorly active on l-Phe and l-His. Histidine 232-237 reactive intermediate imine deaminase A homolog Homo sapiens 39-44 29480716-6 2018 Furthermore, engineered histidine residues in UBA(2) strongly destabilize the iso-1-cytochrome c domain. Histidine 24-33 eukaryotic translation initiation factor 1 Homo sapiens 78-83 29300896-5 2018 The acceptor bead is modified with Ni(II), and is used to bind a specific recombinant HA-binding protein (such as HABP; aggrecan G1-IGD-G2) with a His-tag. Histidine 147-150 hyaluronan binding protein 2 Homo sapiens 114-118 29217657-0 2018 The unique histidine in OSCP subunit of F-ATP synthase mediates inhibition of the permeability transition pore by acidic pH. Histidine 11-20 ATP synthase peripheral stalk subunit OSCP Homo sapiens 24-28 29127553-0 2018 Identification of Histidine 303 as the Catalytic Base of Lysyl Oxidase via Site-Directed Mutagenesis. Histidine 18-27 lysyl oxidase Homo sapiens 57-70 29129814-1 2018 Cav3.2 T-type Ca2+ channel activity is suppressed by zinc that binds to the extracellular histidine-191 of Cav3.2, and enhanced by H2S that interacts with zinc. Histidine 90-99 calcium channel, voltage-dependent, T type, alpha 1H subunit Mus musculus 0-6 29129814-1 2018 Cav3.2 T-type Ca2+ channel activity is suppressed by zinc that binds to the extracellular histidine-191 of Cav3.2, and enhanced by H2S that interacts with zinc. Histidine 90-99 calcium channel, voltage-dependent, T type, alpha 1H subunit Mus musculus 107-113 29342843-6 2018 For the protonated noncovalent complexes of His enantiomers with tripeptides (AAA, SAA, ASA, and AAS), protonated His was observed in the spectra, except for those of heterochiral H+(d-His)SAA and H+(d-His)AAS, indicating that d-His did not accept protons from the SAA and AAS in the noncovalent complexes. Histidine 44-47 serum amyloid A1 cluster Homo sapiens 83-86 29342843-6 2018 For the protonated noncovalent complexes of His enantiomers with tripeptides (AAA, SAA, ASA, and AAS), protonated His was observed in the spectra, except for those of heterochiral H+(d-His)SAA and H+(d-His)AAS, indicating that d-His did not accept protons from the SAA and AAS in the noncovalent complexes. Histidine 44-47 serum amyloid A1 cluster Homo sapiens 189-192 29342843-6 2018 For the protonated noncovalent complexes of His enantiomers with tripeptides (AAA, SAA, ASA, and AAS), protonated His was observed in the spectra, except for those of heterochiral H+(d-His)SAA and H+(d-His)AAS, indicating that d-His did not accept protons from the SAA and AAS in the noncovalent complexes. Histidine 44-47 serum amyloid A1 cluster Homo sapiens 189-192 28833276-11 2017 Otherwise, Arg/His genotype (rs1229984) in ADH1B gene showed a protective effect against HD (aOR = 0.36; 95% CI: 0.14 to 0.90) and BD (aOR = 0.49; 95% CI: 0.21 to 0.95). Histidine 15-18 alcohol dehydrogenase 1B (class I), beta polypeptide Homo sapiens 43-48 28724772-2 2017 Two-hybrid and pulldown assays demonstrated that UL20, but no other HSV-1 gene-encoded proteins, binds specifically to GODZ (also known as DHHC3), a cellular Golgi apparatus-specific Asp-His-His-Cys (DHHC) zinc finger protein. Histidine 187-190 envelope protein UL20 Human alphaherpesvirus 1 49-53 28771333-1 2017 The reactions of picolinyl and 4-chloropicolinyl chlorides with methyl esters of S-methyl-l-cysteine, l- and d-methionine, and l-histidine afforded a series of functionalized carboxamides, which readily formed pincer-type complexes upon interaction with PdCl2(NCPh)2 in solution under mild conditions. Histidine 127-138 phosducin like 2 Homo sapiens 254-266 28483671-9 2017 Conversely, MMP-9 activity in the presence of 50muM acrolein was enhanced by 100muM histidine. Histidine 84-93 matrix metallopeptidase 9 Homo sapiens 12-17 28483671-11 2017 These results suggest that activation of 92kDa MMP-9 by acrolein is involved in tissue damage in pSS patients and is regulated by cysteine and histidine, and slightly by lysine. Histidine 143-152 matrix metallopeptidase 9 Homo sapiens 47-52 28488337-6 2017 Porous laminin (LN)-rich sponge (LN-sponge), on which histidine-tagged VEGF (VEGF-Histag) is immobilized via affinity interaction is developed. Histidine 54-63 vascular endothelial growth factor A Mus musculus 71-75 28488337-6 2017 Porous laminin (LN)-rich sponge (LN-sponge), on which histidine-tagged VEGF (VEGF-Histag) is immobilized via affinity interaction is developed. Histidine 54-63 vascular endothelial growth factor A Mus musculus 77-88 28160314-8 2017 Unexpectedly, we also find that mutating the supposed catalytic histidine (H191) within the conserved HXXXDG active site motif only moderately reduces the thioesterase activity of Atf1p. Histidine 64-73 alcohol O-acetyltransferase Saccharomyces cerevisiae S288C 180-185 28615107-3 2017 Following transformation into E.coli BL21, the soluble fusion protein His-FOXO3 was induced by IPTG and purified by Ni-NTA affinity chromatography. Histidine 70-73 forkhead box O3 Mus musculus 74-79 28471462-6 2017 Copper is bound at the active site of MOR244-3 by cysteine and histidine, while cysteine, histidine and methionine are involved with OR2T11. Histidine 90-99 olfactory receptor family 2 subfamily T member 11 Homo sapiens 133-139 28246171-6 2017 To resolve this discrepancy, we explored the role of the distal histidine residue in muting the reactivity of human neuroglobin toward H2S. Histidine 64-73 neuroglobin Homo sapiens 116-127 28469631-7 2017 All of the PtZIP proteins contained the highly conserved ZIP signature sequences in TM-IV, and nine of them showed a variable region rich in histidine residues between TM-III and TM-IV. Histidine 141-150 Argonaute family protein Arabidopsis thaliana 13-16 27665193-4 2017 The SERS results for BN and its fragment demonstrated that (1) three amino acids from these peptides sequence; i.e., l-histidine, l-methionine, and l-tryptophan, are involved in the interaction with gold coated silicon wafer and (2) the strength of these interactions depends upon the aforementioned amino acids position in the peptide sequence. Histidine 117-128 gastrin releasing peptide Homo sapiens 21-23 28039637-5 2017 Molecular docking studies of compound 3g with CAII showed this compound fits nicely in the active site of CAII and it interacts with the zinc ion ([Formula: see text]) along with three histidine residues in the active site. Histidine 185-194 carbonic anhydrase 2 Homo sapiens 46-50 27775717-7 2016 We used directed mutagenesis to characterize SCAF1 regions that interact with CIII and CIV and discovered that this interaction requires the correct orientation of a histidine residue at position 73 that is altered in the short isoform of SCAF1, explaining its inability to interact with CIV. Histidine 166-175 SR-related CTD-associated factor 1 Mus musculus 45-50 27775717-7 2016 We used directed mutagenesis to characterize SCAF1 regions that interact with CIII and CIV and discovered that this interaction requires the correct orientation of a histidine residue at position 73 that is altered in the short isoform of SCAF1, explaining its inability to interact with CIV. Histidine 166-175 SR-related CTD-associated factor 1 Mus musculus 239-244 27801576-2 2016 The high-spin Fe(II) complexes feature the facially coordinating tris(4,5-diphenyl-1-methylimidazol-2-yl)phosphine (Ph2TIP) ligand that replicates the three histidine (3His) triad of the TDO active sites. Histidine 157-166 tryptophan 2,3-dioxygenase Homo sapiens 187-190 27648609-6 2016 Furthermore, peptide CT-2 (Leu-Gln-Pro-Ser-His-Tyr) potently inhibited melanogenesis in mouse B16 melanoma cells without causing cytotoxicity, suggesting the potential of CT-2 as an agent for melanin-related skin disorder treatment. Histidine 43-46 cardiotrophin 2 Mus musculus 21-25 27648609-6 2016 Furthermore, peptide CT-2 (Leu-Gln-Pro-Ser-His-Tyr) potently inhibited melanogenesis in mouse B16 melanoma cells without causing cytotoxicity, suggesting the potential of CT-2 as an agent for melanin-related skin disorder treatment. Histidine 43-46 cardiotrophin 2 Mus musculus 171-175 27822212-5 2016 A separate cohort of animals was used to detect His-tagged HMGB1 in the brain. Histidine 48-51 high mobility group box 1 Rattus norvegicus 59-64 27661977-7 2016 Hexacoordinate hemoglobins such as neuroglobin are limited by tighter histidine coordination that blocks hydroxylamine binding, and pentacoordinate hemoglobins have intrinsically lower hydroxylamine affinities. Histidine 70-79 neuroglobin Homo sapiens 35-46 27722449-6 2016 The order of reactivity of the studied small biomolecules is: 5"-GMP > GSH > l-Met > l-His. Histidine 94-99 5'-nucleotidase, cytosolic II Homo sapiens 65-68 27374989-8 2016 We suggest that Dm eIF4E-3 and Dm eIF4E-5 bind the second nucleoside of the cap in an unusual manner via stacking interactions with a histidine or a phenylalanine residue, respectively. Histidine 134-143 eukaryotic translation initiation factor 4E5 Drosophila melanogaster 34-41 27382069-7 2016 We also identify an 11 Histidine repeat and the homeodomain of HOXA1 to be required both for RBCK1 and TRAF2 interaction and NF-kappaB stimulation. Histidine 23-32 TNF receptor associated factor 2 Homo sapiens 103-108 27590064-3 2016 Based on the sequence homology, Exo70A1 is divided into four subdomains: leucine zipper (Leu(128)-Leu(149)), hypervariable region (Ser(172)-Leu(197)), SUMO modification motif (Glu(260)-Ile(275)), and pfamExo70 domain (His(271)-Phe(627)). Histidine 218-221 exocyst complex component EXO70A1 Brassica oleracea 32-39 27334921-4 2016 The LECT2 structure adopts a conserved Zn(II) coordination configuration but lacks a proposed catalytic histidine residue, and its potential substrate-binding groove is blocked in the vicinity of the Zn(II)-binding site by an additional intrachain loop at the N terminus. Histidine 104-113 leukocyte cell derived chemotaxin 2 Homo sapiens 4-9 27273166-5 2016 The target enzyme was immobilised on the silica capillary via Schiff base formation (to give LmNDKb-ICER-Schiff) or affinity attachment (to give LmNDKb-ICER-His). Histidine 157-160 cAMP responsive element modulator Homo sapiens 152-156 27323149-5 2016 There was a significant association between the XPG gene Asp1104His polymorphism and lung cancer (His/His vs Asp/Asp: OR = 1.24, 95%CI = 1.04-1.48; Asp/His vs Asp/Asp: OR = 1.17, 95%CI = 1.03-1.34; the dominant model: OR = 1.18, 95%CI = 1.04-1.33; the recessive model: OR = 1.10, 95%CI = 0.94-1.28). Histidine 64-67 ERCC excision repair 5, endonuclease Homo sapiens 48-51 27323149-5 2016 There was a significant association between the XPG gene Asp1104His polymorphism and lung cancer (His/His vs Asp/Asp: OR = 1.24, 95%CI = 1.04-1.48; Asp/His vs Asp/Asp: OR = 1.17, 95%CI = 1.03-1.34; the dominant model: OR = 1.18, 95%CI = 1.04-1.33; the recessive model: OR = 1.10, 95%CI = 0.94-1.28). Histidine 98-101 ERCC excision repair 5, endonuclease Homo sapiens 48-51 27250920-0 2016 Role of Histidine 547 of Human Dopamine Transporter in Molecular Interaction with HIV-1 Tat and Dopamine Uptake. Histidine 8-17 solute carrier family 6 member 3 Homo sapiens 31-51 26476866-7 2016 In case of Fc region of IgG, l-histidine and histidyl moieties closely resemble the binding modes of Protein A, biomimetic ligand 22/8 and B domain of SpA to IgG. Histidine 29-40 surfactant protein A2 Homo sapiens 151-154 26969165-2 2016 We have previously shown that potentiation of CNGA1 channels by transition metals requires a histidine in the A" helix following the S6 transmembrane segment. Histidine 93-102 cyclic nucleotide gated channel subunit alpha 1 Homo sapiens 46-51 27088325-4 2016 Relative to the open bacterial ammonium transporters, non-phosphorylated Mep2 exhibits shifts in cytoplasmic loops and the C-terminal region (CTR) to occlude the cytoplasmic exit of the channel and to interact with His2 of the twin-His motif. Histidine 215-218 ammonium permease MEP2 Saccharomyces cerevisiae S288C 73-77 26691197-2 2016 There are three known Vssc alleles that confer resistance to pyrethroids in the house fly: knock down resistance (kdr; L1014F), super-kdr (M918T + L1014F) and kdr-his (L1014H), but there has been no side-by-side comparison of the resistance levels that they confer. Histidine 163-166 sodium channel protein para-like Musca domestica 22-26 26826131-1 2016 Rpl3, a highly conserved ribosomal protein, is methylated at histidine 243 by the Hpm1 methyltransferase in Saccharomyces cerevisiae. Histidine 61-70 ribosomal 60S subunit protein L3 Saccharomyces cerevisiae S288C 0-4 26826131-2 2016 Histidine 243 lies close to the peptidyl transferase center in a functionally important region of Rpl3 designated as the basic thumb that coordinates the decoding, peptidyl transfer, and translocation steps of translation elongation. Histidine 0-9 ribosomal 60S subunit protein L3 Saccharomyces cerevisiae S288C 98-102 26960429-6 2016 When histidine residues in both the intracellular and extracellular region of hTAS1R2 were exchanged for alanine, taste-modifying effect of MCL was reduced or abolished. Histidine 5-14 taste 1 receptor member 2 Homo sapiens 78-85 27094155-1 2016 The present study was undertaken to investigate the possible protective effect of L-carnosine (CAR), an endogenous dipeptide of alanine and histidine, on carbon tetrachloride (CCl4)-induced hepatic injury. Histidine 140-149 nuclear receptor subfamily 1, group I, member 3 Rattus norvegicus 82-99 26692147-6 2016 Moreover, the presence of the Gln/Gln, Arg/His, and His/His genotypes of XRCC1 was significantly more likely to have bone erosion and extra-articular features in RA patients. Histidine 43-46 X-ray repair cross complementing 1 Homo sapiens 73-78 26472619-3 2016 Ferret recombinant IL-2 incorporating a C-terminal histidine tag was expressed and purified and the three-dimensional structure solved and refined at 1.89 A by X-ray crystallography, which represents the highest resolution and first non-human IL-2 structure. Histidine 51-60 interleukin 2 Mustela putorius furo 19-23 26253506-6 2015 CONCLUSIONS: Through whole exome sequencing and expanded cohort screening, we identified a novel genetic substrate p.Arg518Cys/His-CACNA1C, in patients with a complex phenotype including LQTS, HCM, and congenital heart defects annotated as cardiac-only Timothy syndrome. Histidine 127-130 calcium voltage-gated channel subunit alpha1 C Homo sapiens 131-138 26195630-6 2015 In contrast, mutations in the C-terminal hinge-cysteine-histidine-rich domain segment primarily affected the PCSK9-induced CD81 degradation. Histidine 56-65 CD81 molecule Homo sapiens 123-127 26195630-7 2015 Furthermore, when C-terminally fused to an ACE2 transmembrane anchor, the secretory N-terminal catalytic or hinge-cysteine-histidine-rich domain domains of PCSK9 were able to reduce CD81 and LDLR levels. Histidine 123-132 CD81 molecule Homo sapiens 182-186 26216015-1 2015 Thyrotropin-releasing hormone (TRH)-like peptides were synthesized by replacing critical histidine and pGlu residues in the native peptide. Histidine 89-98 thyrotropin releasing hormone Mus musculus 0-29 26249842-5 2015 Our simulations have also identified crucial aromatic-aromatic interactions which stabilize the orientation of the catalytic histidine for inline nucleophilic attack during AMPylation, thus providing a structural basis for the evolutionary conservation of these aromatic residue pairs in Fic domains. Histidine 125-134 C-C motif chemokine ligand 7 Homo sapiens 288-291 26305187-3 2015 To further study RTVP-1 effects we performed a pull-down assay using His-tagged RTVP-1 followed by mass spectrometry and found that RTVP-1 was associated with the actin polymerization regulator, N-WASP. Histidine 69-72 GLI pathogenesis related 1 Homo sapiens 17-23 26305187-3 2015 To further study RTVP-1 effects we performed a pull-down assay using His-tagged RTVP-1 followed by mass spectrometry and found that RTVP-1 was associated with the actin polymerization regulator, N-WASP. Histidine 69-72 GLI pathogenesis related 1 Homo sapiens 80-86 26305187-3 2015 To further study RTVP-1 effects we performed a pull-down assay using His-tagged RTVP-1 followed by mass spectrometry and found that RTVP-1 was associated with the actin polymerization regulator, N-WASP. Histidine 69-72 GLI pathogenesis related 1 Homo sapiens 80-86 25900360-2 2015 The three CcP variants have Arg-48, Trp-51, and His-52 mutated to either all alanine, CcP(triAla), all valine, CcP(triVal), or all leucine residues, CcP(triLeu). Histidine 48-51 cytochrome-c peroxidase Saccharomyces cerevisiae S288C 10-13 26041283-8 2015 The covalent linking between nsP1 and m(7)GMP involves a phosphamide bond between the nucleotide and a histidine residue. Histidine 103-112 SH2 domain containing 3A Homo sapiens 29-33 26041283-8 2015 The covalent linking between nsP1 and m(7)GMP involves a phosphamide bond between the nucleotide and a histidine residue. Histidine 103-112 5'-nucleotidase, cytosolic II Homo sapiens 42-45 26144885-1 2015 5-Aminoimidazole-4-carboxamide ribonucleotide (known as ZMP) is a metabolite produced in de novo purine biosynthesis and histidine biosynthesis, but only utilized in the cell by a homodimeric bifunctional enzyme (called ATIC) that catalyzes the last two steps of de novo purine biosynthesis. Histidine 121-130 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase Mus musculus 220-224 26200004-3 2015 (2015) show that a histidine residue in the RNA binding pocket of RIG-I sterically excludes the cap1 structure of self RNA, thereby preventing downstream activation. Histidine 19-28 DExD/H-box helicase 58 Homo sapiens 66-71 25805806-1 2015 Among more than 30 members of the phospholipase A2 (PLA2) superfamily, secreted PLA2 (sPLA2) enzymes represent the largest family, being Ca(2+)-dependent low-molecular-weight enzymes with a His-Asp catalytic dyad. Histidine 190-193 phospholipase A2, group IB, pancreas Mus musculus 34-50 25805806-1 2015 Among more than 30 members of the phospholipase A2 (PLA2) superfamily, secreted PLA2 (sPLA2) enzymes represent the largest family, being Ca(2+)-dependent low-molecular-weight enzymes with a His-Asp catalytic dyad. Histidine 190-193 phospholipase A2, group IB, pancreas Mus musculus 52-56 25805806-1 2015 Among more than 30 members of the phospholipase A2 (PLA2) superfamily, secreted PLA2 (sPLA2) enzymes represent the largest family, being Ca(2+)-dependent low-molecular-weight enzymes with a His-Asp catalytic dyad. Histidine 190-193 phospholipase A2, group IB, pancreas Mus musculus 80-84 25805806-1 2015 Among more than 30 members of the phospholipase A2 (PLA2) superfamily, secreted PLA2 (sPLA2) enzymes represent the largest family, being Ca(2+)-dependent low-molecular-weight enzymes with a His-Asp catalytic dyad. Histidine 190-193 phospholipase A2, group IIA (platelets, synovial fluid) Mus musculus 86-91 25497832-2 2015 The protein sequence of yellow catfish SCD1 and Fads2 (Delta6) possessed all the characteristics of microsomal fatty acid Fads2 (Delta6), including three histidine boxes, two transmembrane regions and one N-terminal cytochrome b5 domain containing heme-binding motif. Histidine 154-163 stearoyl-CoA desaturase Homo sapiens 39-43 25962097-0 2015 A conserved histidine modulates HSPB5 structure to trigger chaperone activity in response to stress-related acidosis. Histidine 12-21 crystallin alpha B Homo sapiens 32-37 25572019-5 2015 We used homo-FRET measurements between fluorescein-E-G-R-chloromethylketone (CK)-Xa [fXa irreversibly inactivated by alkylation of the active site histidine residue with FEGR (FEGR-fXa)] and prothrombinase activity measurements to reveal the balance between fXa dimer formation and fXa-fVa complex formation. Histidine 147-156 coagulation factor X Homo sapiens 85-88 25615976-1 2015 Structures of the catalytic N-acetyltransferase (NAT) domain of the bifunctional N-acetyl-L-glutamate synthase/kinase (NAGS/K) from Xylella fastidiosa bound to N-acetyl-L-glutamate (NAG) with and without an N-terminal His tag have been solved and refined at 1.7 and 1.4 A resolution, respectively. Histidine 218-221 N-acetylglutamate synthase Homo sapiens 119-123 25572553-2 2015 Among the PLA2 superfamily, secreted PLA2 (sPLA2) enzymes comprise the largest subfamily that includes 11 isoforms with a conserved His-Asp catalytic dyad. Histidine 132-135 phospholipase A2, group IIA (platelets, synovial fluid) Mus musculus 10-14 25572553-2 2015 Among the PLA2 superfamily, secreted PLA2 (sPLA2) enzymes comprise the largest subfamily that includes 11 isoforms with a conserved His-Asp catalytic dyad. Histidine 132-135 phospholipase A2, group IIA (platelets, synovial fluid) Mus musculus 37-41 25572553-2 2015 Among the PLA2 superfamily, secreted PLA2 (sPLA2) enzymes comprise the largest subfamily that includes 11 isoforms with a conserved His-Asp catalytic dyad. Histidine 132-135 phospholipase A2, group IIA (platelets, synovial fluid) Mus musculus 43-48 25151410-5 2014 The histidine forms eight hydrogen bonds with HisRS of which six engage the amino and carboxylate groups of this amino acid. Histidine 4-13 histidyl-tRNA synthetase 2, mitochondrial Homo sapiens 46-51 25283071-0 2014 Mono-anionic phosphopeptides produced by unexpected histidine alkylation exhibit high Plk1 polo-box domain-binding affinities and enhanced antiproliferative effects in HeLa cells. Histidine 52-61 polo like kinase 1 Homo sapiens 86-90 25295538-2 2014 Here, through transcriptional profiling of genetically labeled cardiomyocytes, we identified expression of Purkinje cell protein-4 (Pcp4), a putative regulator of calmodulin and Ca2+/calmodulin-dependent kinase II (CaMKII) signaling, exclusively within the His-Purkinje network. Histidine 257-260 calcium/calmodulin-dependent protein kinase II, beta Mus musculus 215-221 25332048-3 2014 We found that XPG Asp1104His polymorphism was associated with a significantly increased CRC risk (dominant model: His/His + Asp/His vs. Asp/Asp, adjusted OR = 1.39, 95% CI = 1.14-1.69). Histidine 25-28 ERCC excision repair 5, endonuclease Homo sapiens 14-17 25332048-3 2014 We found that XPG Asp1104His polymorphism was associated with a significantly increased CRC risk (dominant model: His/His + Asp/His vs. Asp/Asp, adjusted OR = 1.39, 95% CI = 1.14-1.69). Histidine 114-117 ERCC excision repair 5, endonuclease Homo sapiens 14-17 25332048-3 2014 We found that XPG Asp1104His polymorphism was associated with a significantly increased CRC risk (dominant model: His/His + Asp/His vs. Asp/Asp, adjusted OR = 1.39, 95% CI = 1.14-1.69). Histidine 114-117 ERCC excision repair 5, endonuclease Homo sapiens 14-17 25100325-0 2014 The C113D mutation in human Pin1 causes allosteric structural changes in the phosphate binding pocket of the PPIase domain through the tug of war in the dual-histidine motif. Histidine 158-167 peptidylprolyl isomerase like 1 Homo sapiens 109-115 25082511-0 2014 Mono- and di-halogenated histamine, histidine and carnosine derivatives are potent carbonic anhydrase I, II, VII, XII and XIV activators. Histidine 36-45 carbonic anhydrase 1 Homo sapiens 83-112 25401070-1 2014 In this study (S)-3-hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase (H16_A0461/FadB", gene ID: 4247876) from one of two active fatty acid degradation operons of Ralstonia eutropha H16 has been heterologously expressed in Escherichia coli, purified as protein possessing a His-Tag and initially characterized. Histidine 274-277 H16_RS08555 Ralstonia eutropha H16 50-69 24962580-6 2014 However, addition of two PAM residues (Arg(126)-His(127)) to the COOH terminus of VEK30 (VEK32) maintained a monomeric peptidic structure, but exhibited similar K2hPg binding affinity as full-length dimeric PAM. Histidine 48-51 peptidylglycine alpha-amidating monooxygenase Homo sapiens 25-28 24962580-7 2014 We identified five residues in a1a2 (Arg(113), His(114), Glu(116), Arg(126), His(127)), mutation of which reduced PAM binding affinity for K2hPg by ~ 1000-fold. Histidine 47-50 peptidylglycine alpha-amidating monooxygenase Homo sapiens 114-117 24962580-7 2014 We identified five residues in a1a2 (Arg(113), His(114), Glu(116), Arg(126), His(127)), mutation of which reduced PAM binding affinity for K2hPg by ~ 1000-fold. Histidine 77-80 peptidylglycine alpha-amidating monooxygenase Homo sapiens 114-117 24858299-11 2014 At acidic pH (pH<6.5), ionic and hydrophobic interactions, created by histidine protonation and hydrophobic amino acids, appeared in the Abeta/HSPG binding. Histidine 73-82 syndecan 2 Homo sapiens 146-150 25606432-4 2014 L23a is highly basic, containing a combined 45 Arg, Lys, and His residues and only 14 Asp and Glu residues. Histidine 61-64 ribosomal protein L23a Homo sapiens 0-4 24706759-8 2014 Substitution of Thr-30 and His-160 in GLUT1 to the corresponding positions in GLUT4 is sufficient to completely transform GLUT1 into GLUT4 with respect to indinavir inhibition of 2-DOG uptake and ATB-BMPA binding. Histidine 27-30 solute carrier family 2 member 1 Homo sapiens 38-43 24706759-8 2014 Substitution of Thr-30 and His-160 in GLUT1 to the corresponding positions in GLUT4 is sufficient to completely transform GLUT1 into GLUT4 with respect to indinavir inhibition of 2-DOG uptake and ATB-BMPA binding. Histidine 27-30 solute carrier family 2 member 4 Canis lupus familiaris 78-83 24706759-8 2014 Substitution of Thr-30 and His-160 in GLUT1 to the corresponding positions in GLUT4 is sufficient to completely transform GLUT1 into GLUT4 with respect to indinavir inhibition of 2-DOG uptake and ATB-BMPA binding. Histidine 27-30 solute carrier family 2 member 1 Homo sapiens 122-127 24706759-8 2014 Substitution of Thr-30 and His-160 in GLUT1 to the corresponding positions in GLUT4 is sufficient to completely transform GLUT1 into GLUT4 with respect to indinavir inhibition of 2-DOG uptake and ATB-BMPA binding. Histidine 27-30 solute carrier family 2 member 4 Canis lupus familiaris 133-138 24905281-4 2014 Using an assay that mimics Rac1 membrane anchoring by using Rac1-His and liposomes containing Ni(2+)-NTA modified lipids, we demonstrate that intrinsic Tiam1 DH-PH activity increases when Rac1 is anchored in a PtdIns5P-enriched environment. Histidine 65-68 Rac family small GTPase 1 Homo sapiens 60-64 24905281-4 2014 Using an assay that mimics Rac1 membrane anchoring by using Rac1-His and liposomes containing Ni(2+)-NTA modified lipids, we demonstrate that intrinsic Tiam1 DH-PH activity increases when Rac1 is anchored in a PtdIns5P-enriched environment. Histidine 65-68 TIAM Rac1 associated GEF 1 Homo sapiens 152-157 24905281-4 2014 Using an assay that mimics Rac1 membrane anchoring by using Rac1-His and liposomes containing Ni(2+)-NTA modified lipids, we demonstrate that intrinsic Tiam1 DH-PH activity increases when Rac1 is anchored in a PtdIns5P-enriched environment. Histidine 65-68 Rac family small GTPase 1 Homo sapiens 60-64 24819655-5 2014 On the other hand, in the presence of L-histidine or L-arginine, [Eu(pda)2](-) exhibited intense CPL (glum ~ 0.08 for the (5)D0 (7)F1 transition at 0.10 mol dm(-3) of the amino acid), whereas quite weak CPL was observed for [Eu(bda)2](-) under the same conditions (glum < 0.01). Histidine 38-49 hephaestin Homo sapiens 97-100 24754256-1 2014 Membrane transporter PhT2 (SLC15A3), which belongs to the proton-coupled oligopeptide transporter family, mediates the transport of di/tripeptides and histidine utilizing an inwardly directed proton gradient and negative membrane potential. Histidine 151-160 solute carrier family 15 member 3 Homo sapiens 21-25 24571269-0 2014 Conserved histidine of metal transporter AtNRAMP1 is crucial for optimal plant growth under manganese deficiency at chilling temperatures. Histidine 10-19 natural resistance-associated macrophage protein 1 Arabidopsis thaliana 41-49 24571269-9 2014 Chlorotic phenotype was associated with a histidine to tyrosine (H239Y) substitution in the allele of Hog NRAMP1. Histidine 42-51 natural resistance-associated macrophage protein 1 Arabidopsis thaliana 106-112 24506189-3 2014 Substitution of His66 in the blue fluorescent protein (BFP) with these histidine analogues created mutant proteins with distinct spectral properties. Histidine 71-80 ring finger protein 112 Homo sapiens 55-58 24802942-5 2014 Overall, significantly elevated cancer risk was found when all studies were pooled into the meta-analysis of XPG Asp1104His (dominant model: OR = 1.05, 95% CI = 1.00-1.10; Asp/His vs. Asp/Asp: OR = 1.06, 95% CI = 1.01-1.11). Histidine 120-123 ERCC excision repair 5, endonuclease Homo sapiens 109-112 24627494-3 2014 We explored the hypothesis that a conserved His-rich cluster (His-Gly-His-His) in the linker region connecting its two catalytic domains senses pH and affects PAM trafficking by mutating these His residues to Ala (Ala-Gly-Ala-Ala; H3A). Histidine 44-47 zinc finger protein 106 Mus musculus 231-234 24627494-3 2014 We explored the hypothesis that a conserved His-rich cluster (His-Gly-His-His) in the linker region connecting its two catalytic domains senses pH and affects PAM trafficking by mutating these His residues to Ala (Ala-Gly-Ala-Ala; H3A). Histidine 62-65 zinc finger protein 106 Mus musculus 231-234 24627494-3 2014 We explored the hypothesis that a conserved His-rich cluster (His-Gly-His-His) in the linker region connecting its two catalytic domains senses pH and affects PAM trafficking by mutating these His residues to Ala (Ala-Gly-Ala-Ala; H3A). Histidine 62-65 zinc finger protein 106 Mus musculus 231-234 24627494-3 2014 We explored the hypothesis that a conserved His-rich cluster (His-Gly-His-His) in the linker region connecting its two catalytic domains senses pH and affects PAM trafficking by mutating these His residues to Ala (Ala-Gly-Ala-Ala; H3A). Histidine 62-65 zinc finger protein 106 Mus musculus 231-234 24627494-3 2014 We explored the hypothesis that a conserved His-rich cluster (His-Gly-His-His) in the linker region connecting its two catalytic domains senses pH and affects PAM trafficking by mutating these His residues to Ala (Ala-Gly-Ala-Ala; H3A). Histidine 62-65 zinc finger protein 106 Mus musculus 231-234 24747442-0 2014 Immobilised histidine tagged beta2-adrenoceptor oriented by a diazonium salt reaction and its application in exploring drug-protein interaction using ephedrine and pseudoephedrine as probes. Histidine 12-21 adrenoceptor beta 2 Homo sapiens 29-47 24342540-4 2014 Molecular simulation analysis suggest that the presence of Tyr or Glu may contribute to the formation of the breakwater network, the stabilization of distal histidine, the changes in the size of heme pocket, and eventually result in the inhibition of metHb formation. Histidine 157-166 hemoglobin subunit gamma 2 Homo sapiens 251-256 24637767-4 2014 Here, full-length human RIG-I (hRIG-I) was cloned in Escherichia coli and expressed in a recombinant form with a His-SUMO tag. Histidine 113-116 DExD/H-box helicase 58 Homo sapiens 24-29 24637767-4 2014 Here, full-length human RIG-I (hRIG-I) was cloned in Escherichia coli and expressed in a recombinant form with a His-SUMO tag. Histidine 113-116 DExD/H-box helicase 58 Homo sapiens 31-37 24441828-5 2014 The introduction of metal-binding histidines at this site converts RyR2 into a luminal Ni(2+)-gated channel. Histidine 34-44 ryanodine receptor 2, cardiac Mus musculus 67-71 24282278-8 2014 Moreover, His-MDA-7, after binding to its cognate receptors (IL-20R1/IL-20R2 or IL-22R/IL-20R2), induces intracellular signaling by phosphorylation of p38 MAPK, leading to transcription of a family of growth arrest and DNA damage inducible (GADD) genes, culminating in apoptosis. Histidine 10-13 interleukin 20 receptor subunit alpha Homo sapiens 61-68 25009988-8 2014 Results showed that the protein BANF1 fusion with the N-terminally His-tagged form gave rise to the accumulation of an expected 14 kD polypeptide that formed inclusion bodies. Histidine 67-70 barrier-to-autointegration factor Ailuropoda melanoleuca 32-37 24349317-4 2013 We predicted a novel molecular model for ECP binding of heparin hexasaccharide (Hep6), [GlcNS(6S)-IdoA(2S)]3, and residues Gln(40), His(64) and Arg(105) were indicated as major contributions for the interaction. Histidine 132-135 ribonuclease A family member 3 Homo sapiens 41-44 24349317-5 2013 Interestingly, Gln(40) and His(64) on ECP formed a clamp-like structure to stabilize Hep6 in our model, which was not observed in the corresponding residues on EDN. Histidine 27-30 ribonuclease A family member 3 Homo sapiens 38-41 24349317-7 2013 Weaker binding of ECP Q40A/H64A of all heparin variants suggested that Gln(40)-His(64) clamp contributed to ECP-heparin interaction significantly. Histidine 79-82 ribonuclease A family member 3 Homo sapiens 18-21 24349317-7 2013 Weaker binding of ECP Q40A/H64A of all heparin variants suggested that Gln(40)-His(64) clamp contributed to ECP-heparin interaction significantly. Histidine 79-82 ribonuclease A family member 3 Homo sapiens 108-111 23973428-4 2013 Pyrophosphate released by the amino acid-aaRS binding reaction was detected by luminol chemiluminescence; the method provided selective quantitation of 1.0-30 muM histidine and 1.0-60 muM lysine. Histidine 163-172 alanyl-tRNA synthetase 1 Homo sapiens 41-45 24121506-5 2013 Within L1C domains, five amino acid residues (Leu-135, Gly-188, Arg-244, and vicinal His-318 and Lys-319) were identified as IRR-specific by species conservation analysis of the IR family. Histidine 85-88 insulin receptor related receptor Homo sapiens 125-128 24260525-5 2013 In addition, detailed analysis demonstrated that USP25 cleaved lysine 48- and lysine 63-linked polyubiquitin chains in vitro and in vivo, and its deubiquitinating enzyme (DUB) activity, were dependent on a cysteine residue (Cys178) and a histidine residue (His607). Histidine 238-247 ubiquitin specific peptidase 25 Homo sapiens 49-54 23733202-2 2013 XRCC1 codon 280 polymorphism is an Arg-His change in the XRCC1 gene. Histidine 39-42 X-ray repair cross complementing 1 Homo sapiens 0-5 24086538-1 2013 Mutated mouse lipoprotein lipase (LPL) containing a leucine (L) to histidine (H) substitution at position 452 was transferred into mouse liver by hydrodynamics-based gene delivery (HD). Histidine 67-76 lipoprotein lipase Mus musculus 14-32 24086538-1 2013 Mutated mouse lipoprotein lipase (LPL) containing a leucine (L) to histidine (H) substitution at position 452 was transferred into mouse liver by hydrodynamics-based gene delivery (HD). Histidine 67-76 lipoprotein lipase Mus musculus 34-37 24043698-6 2013 http://dx.doi.org/10.1083/jcb.201308034) show that pHi increase activates FAK by causing deprotonation of histidine 58 in its FERM (band 4.1, ezrin, radixin, moesin) homology domain, which exposes a region important for FAK autophosphorylation. Histidine 106-115 erythrocyte membrane protein band 4.1 Homo sapiens 132-140 24579556-9 2013 Direct sequencing detected a recurrent heterozygous missense c.1877A > G mutation in exon 14 of the TGFBI gene, resulting in substitution of histidine with arginine (p.H626R). Histidine 144-153 transforming growth factor beta induced Homo sapiens 103-108 23844178-4 2013 Hypomorphic mutations in histidine decarboxylase (HDC), an enzyme catalyzing the conversion from histidine to histamine, caused an increase in sleep duration. Histidine 25-34 Histidine decarboxylase Drosophila melanogaster 50-53 23564659-4 2013 On the basis of a peptide reported in the literature, referred to here as the Parent Peptide (H-Aib-Val-Aib-Glu-Ile-Gln-Leu-Nle-His-Gln-Har-NH2), we conducted systematic SAR analyses to investigate the effects of altering peptide hydrophobicity on PTH receptor functional potency as measured by the cAMP (cyclic adenosine monophosphate) accumulation and beta-arrestin recruitment assays. Histidine 128-131 ANIB1 Homo sapiens 96-99 23564659-4 2013 On the basis of a peptide reported in the literature, referred to here as the Parent Peptide (H-Aib-Val-Aib-Glu-Ile-Gln-Leu-Nle-His-Gln-Har-NH2), we conducted systematic SAR analyses to investigate the effects of altering peptide hydrophobicity on PTH receptor functional potency as measured by the cAMP (cyclic adenosine monophosphate) accumulation and beta-arrestin recruitment assays. Histidine 128-131 ANIB1 Homo sapiens 104-107 23500601-0 2013 Appraisal of sildenafil binding on the structure and promiscuous esterase activity of native and histidine-modified forms of carbonic anhydrase II. Histidine 97-106 carbonic anhydrase 2 Homo sapiens 125-146 23330737-9 2013 Melatonin docked into the active site cleft of MMP-9 and interacted with key catalytic site residues including the three histidines that form the coordination complex with the catalytic zinc as well as proline 421 and alanine 191. Histidine 121-131 matrix metallopeptidase 9 Homo sapiens 47-52 23592913-6 2013 Sequencing of the candidate genes revealed a heterozygous c. 139G>C change in the coding sequence of the connexin 50 gene (gap junction protein, alpha 8 [GJA8]), which results in the substitution of a wild-type aspartic acid with a histidine (D47H). Histidine 235-244 gap junction protein alpha 8 Homo sapiens 108-119 23592913-6 2013 Sequencing of the candidate genes revealed a heterozygous c. 139G>C change in the coding sequence of the connexin 50 gene (gap junction protein, alpha 8 [GJA8]), which results in the substitution of a wild-type aspartic acid with a histidine (D47H). Histidine 235-244 gap junction protein alpha 8 Homo sapiens 126-155 23592913-6 2013 Sequencing of the candidate genes revealed a heterozygous c. 139G>C change in the coding sequence of the connexin 50 gene (gap junction protein, alpha 8 [GJA8]), which results in the substitution of a wild-type aspartic acid with a histidine (D47H). Histidine 235-244 gap junction protein alpha 8 Homo sapiens 157-161 23517193-3 2013 In addition to simplifying the purification procedure, introduction of a His tag at either protein terminus dramatically increases its solubility, allowing preparation of concentrated, stable CcP samples required for multidimensional NMR spectroscopy. Histidine 73-76 cytochrome-c peroxidase Saccharomyces cerevisiae S288C 192-195 23517193-5 2013 The His-tagged CcP constructs remain catalytically active yet exhibit differences in the interaction with cytochrome c, the physiological binding partner, most likely because of steric occlusion of the high-affinity binding site by the C-terminal His tag. Histidine 4-7 cytochrome-c peroxidase Saccharomyces cerevisiae S288C 15-18 23425027-3 2013 The XRCC1 codon 280 His carriers (Arg/His+His/His) held a significantly lower risk of distant metastasis in the dominant model (Pearson chi-square test P=0.019). Histidine 20-23 X-ray repair cross complementing 1 Homo sapiens 4-9 23425027-3 2013 The XRCC1 codon 280 His carriers (Arg/His+His/His) held a significantly lower risk of distant metastasis in the dominant model (Pearson chi-square test P=0.019). Histidine 38-41 X-ray repair cross complementing 1 Homo sapiens 4-9 23425027-3 2013 The XRCC1 codon 280 His carriers (Arg/His+His/His) held a significantly lower risk of distant metastasis in the dominant model (Pearson chi-square test P=0.019). Histidine 38-41 X-ray repair cross complementing 1 Homo sapiens 4-9 23425027-3 2013 The XRCC1 codon 280 His carriers (Arg/His+His/His) held a significantly lower risk of distant metastasis in the dominant model (Pearson chi-square test P=0.019). Histidine 38-41 X-ray repair cross complementing 1 Homo sapiens 4-9 23142425-9 2013 Subjects carrying the UGT2B7 268 His/Tyr or Tyr/Tyr genotype had significantly lower total NNAL than those carrying His/His genotype. Histidine 33-36 UDP glucuronosyltransferase family 2 member B7 Homo sapiens 22-28 23135388-0 2013 Heme orientation modulates histidine dissociation and ligand binding kinetics in the hexacoordinated human neuroglobin. Histidine 27-36 neuroglobin Homo sapiens 107-118 22959971-0 2012 Mechanistic studies of the role of a conserved histidine in a mammalian polyamine oxidase. Histidine 47-56 polyamine oxidase Homo sapiens 72-89 22959971-2 2012 While no structure has been reported for a mammalian polyamine oxidase, sequence alignments of polyamine oxidizing flavoproteins identify a conserved histidine residue. Histidine 150-159 polyamine oxidase Homo sapiens 53-70 22959971-4 2012 The corresponding histidine in mouse polyamine oxidase, His64, has been mutated to glutamine, asparagine, and alanine to determine if this residue plays a similar role in the mammalian enzymes. Histidine 18-27 polyamine oxidase Saccharomyces cerevisiae S288C 37-54 23012369-9 2012 In this study, we explored the development of appetite-reducing peptides by synthesizing MC4R agonists based on the insertion of the His-Phe-Arg-Trp sequence into the cyclotide kalata B1. Histidine 133-136 melanocortin 4 receptor Homo sapiens 89-93 23677194-9 2012 The genetic study identified a homozygous mutation of the MUTYH gene, called c.340T > C, that produces an amino acid change of tyrosine for histidine called p.Y114H. Histidine 143-152 mutY DNA glycosylase Homo sapiens 58-63 22705350-4 2012 Pull-down assays using GST-beta-catenin and His-Rad6B deletion mutants identified amino acids 131-181 and 50-116, respectively, as necessary for their interaction. Histidine 44-47 ubiquitin conjugating enzyme E2 B Homo sapiens 48-53 22919255-8 2012 For XRCC1 Arg280His polymorphism, the overall analysis revealed the significant association between the His/His genotype and the increased risk of HCC (His/His vs Arg/Arg model, OR: 1.96, 95% CI: 1.03-3.75, P = 0.04). Histidine 16-19 X-ray repair cross complementing 1 Homo sapiens 4-9 22367578-7 2012 The resulting L-histidine may subsequently be converted into histamine, which could be responsible for the effects of CAR on neurotransmission and physiological function. Histidine 14-25 nuclear receptor subfamily 1, group I, member 3 Rattus norvegicus 118-121 22773744-9 2012 Site-directed mutagenesis showed that CER1 His clusters are essential for alkane synthesis, whereas those of CER3 are not, suggesting that CYTB5s are specific CER1 cofactors. Histidine 43-46 Hsp70 family chaperone LHS1 Saccharomyces cerevisiae S288C 38-42 22556417-7 2012 In rP2X2, one of these histidines is replaced by a lysine, and in a background in which zinc potentiation was eliminated, mutation of Lys-197 to histidine converted rP2X2 from low potency to high potency inhibition. Histidine 23-33 purinergic receptor P2X 2 Rattus norvegicus 165-170 22458729-3 2012 Spectroscopic characterization of CymA from Shewanella oneidensis strain MR-1 identifies three low-spin His/His co-ordinated c-haems and a single high-spin c-haem with His/H(2)O co-ordination lying adjacent to the quinol-binding site. Histidine 104-107 cytochrome c Shewanella oneidensis MR-1 34-38 22458729-3 2012 Spectroscopic characterization of CymA from Shewanella oneidensis strain MR-1 identifies three low-spin His/His co-ordinated c-haems and a single high-spin c-haem with His/H(2)O co-ordination lying adjacent to the quinol-binding site. Histidine 108-111 cytochrome c Shewanella oneidensis MR-1 34-38 22458729-3 2012 Spectroscopic characterization of CymA from Shewanella oneidensis strain MR-1 identifies three low-spin His/His co-ordinated c-haems and a single high-spin c-haem with His/H(2)O co-ordination lying adjacent to the quinol-binding site. Histidine 108-111 cytochrome c Shewanella oneidensis MR-1 34-38 22880226-0 2012 [Functional analysis for dysfibrinogenemias, Toyama and Adachi, which have a mutation of Aalpha16Arg-->His (CGT-->CAT) with aberrant fibrinopeptide A release]. Histidine 106-109 UDP glycosyltransferase 8 Homo sapiens 111-114 22450164-4 2012 Western blot analysis using an anti-His antibody showed that the His-AtCaN2 fusion protein was not degraded. Histidine 36-39 Ca(2+)-dependent nuclease family protein Arabidopsis thaliana 69-75 22500757-0 2012 pH-responsive titratable inotropic performance of histidine-modified cardiac troponin I. Histidine 50-59 troponin I3, cardiac type Homo sapiens 69-87 22500757-2 2012 Studies have shown that a histidine button engineered into cTnI (cTnI A164H) specifically enhances inotropic function in the context of numerous pathophysiological challenges. Histidine 26-35 troponin I3, cardiac type Homo sapiens 59-63 22500757-2 2012 Studies have shown that a histidine button engineered into cTnI (cTnI A164H) specifically enhances inotropic function in the context of numerous pathophysiological challenges. Histidine 26-35 troponin I3, cardiac type Homo sapiens 65-69 22500757-4 2012 We also assessed the role of histidine-modified cTnI in silico by means of molecular dynamics simulations. Histidine 29-38 troponin I3, cardiac type Homo sapiens 48-52 22500757-8 2012 In contrast, simulations of protonated cTnI A164H showed various potential structural configurations, one of which included a salt bridge between His-164 of cTnI and Glu-19 of cTnC. Histidine 146-149 troponin I3, cardiac type Homo sapiens 39-43 22500757-8 2012 In contrast, simulations of protonated cTnI A164H showed various potential structural configurations, one of which included a salt bridge between His-164 of cTnI and Glu-19 of cTnC. Histidine 146-149 troponin I3, cardiac type Homo sapiens 157-161 22500757-10 2012 These data suggest that differential histidine ionization may be necessary for cTnI A164H to act as a molecular sensor capable of modulating sarcomere performance in response to changes in the cytosolic milieu. Histidine 37-46 troponin I3, cardiac type Homo sapiens 79-83 22278351-3 2012 METHODS: [(99m)Tc(CO)(3)(OH(2))(3)](+) was prepared and taken to directly label his(6)-annexin A5. Histidine 80-83 annexin A5 Mus musculus 87-97 22278351-7 2012 RESULTS: The radiochemical purity of (99m)Tc(I)-his(6)-annexin A5 could attain >=95%. Histidine 48-51 annexin A5 Mus musculus 55-65 22240035-0 2012 Distinct roles in folding, CD81 receptor binding and viral entry for conserved histidine residues of hepatitis C virus glycoprotein E1 and E2. Histidine 79-88 CD81 molecule Homo sapiens 27-31 26593369-0 2012 The Protonation States of the Active-Site Histidines in (6-4) Photolyase. Histidine 42-52 (6-4)-photolyase Drosophila melanogaster 57-72 22185821-2 2012 Given the existence of a tight interplay of the Nrf2/NF-kappaB systems and that the pro-inflammatory response is governed by transcription factor NF-kappaB, here we sought to investigate whether and how cyclo(His-Pro) interferes with the cross-talk between the antioxidant Nrf2/heme oxygenase-1 and the pro-inflammatory NF-kappaB pathways. Histidine 209-212 heme oxygenase 1 Rattus norvegicus 278-294 22185821-3 2012 By knocking down the Nrf2 gene, we confirmed that cyclo(His-Pro) inhibits NF-kappaB nuclear accumulation induced by paraquat in rat pheochromocytoma PC12 cells via the Nrf2/heme oxygenase-1 pathway. Histidine 56-59 heme oxygenase 1 Rattus norvegicus 173-189 22139846-6 2012 Expression of HvMTP1/AtMTP1 chimeras in yeast revealed a five-residue sequence within the AtMTP1 N-segment of the His-rich intracytoplasmic loop that confines specificity to Zn(2+). Histidine 114-117 putative Zn transporter Hordeum vulgare 14-20 22730687-5 2012 The frequency (6.7%) of XRCC1-280 His/His in case group was significantly higher than that (4.3%) in control group (P < 0.05), OR for lung cancer was 2.46 (95% CI: 1.141-5.304). Histidine 34-37 X-ray repair cross complementing 1 Homo sapiens 24-29 22730687-5 2012 The frequency (6.7%) of XRCC1-280 His/His in case group was significantly higher than that (4.3%) in control group (P < 0.05), OR for lung cancer was 2.46 (95% CI: 1.141-5.304). Histidine 38-41 X-ray repair cross complementing 1 Homo sapiens 24-29 22730687-8 2012 The risks of lung cancer in smokers with XRCC1-194 Arg/Trp+Trp/Trp and XRCC1-280 His/His+Arg/His were 4.889 (95% CI: 2.828-8.452) and 6.281(95% CI: 3.572-11.046), respectively. Histidine 81-84 X-ray repair cross complementing 1 Homo sapiens 71-76 22199132-4 2011 The k(cat)/K(m) values of Nma-Phe-His-Lys(Dnp), Nma-His-Pro-Phe-Lys(Dnp)-Pro, and Hip-His-Leu were 5.12, 1.90, and 0.80 microM(-1) s(-1) for rabbit lung ACE, and 16.0, 7.36, and 0.30 microM(-1) s(-1) for recombinant human (rh)-ACE, respectively. Histidine 34-37 angiotensin-converting enzyme Oryctolagus cuniculus 153-156 21892195-5 2011 We constructed plasmid pET28a (+)-His(6)-tobacco etch virus (TEV)-eppin for expression in Escherichia coli. Histidine 34-37 epididymal peptidase inhibitor Mus musculus 66-71 21785859-6 2011 In addition, cysteine and histidine significantly inhibited the expression of ICAM-1 and production of IL-8 in THP-1 cells and PBMCs. Histidine 26-35 intercellular adhesion molecule 1 Homo sapiens 78-84 21895659-1 2011 beta-Lactotensin (His-Ile-Arg-Leu) is a bioactive peptide derived from bovine milk beta-lactoglobulin, acting as a natural agonist for neurotensin receptors. Histidine 18-21 beta-lactoglobulin Bos taurus 83-101 22045708-10 2011 SPECT analyses demonstrated a significant increase in tumoral (99m)Tc-(CO)(3) His-annexin A5 uptake 4 d after bevacizumab treatment and 24 h after irinotecan administration (232.78 +- 24.82 percentage injected dose/tumor weight [g]/body weight [kg], P < 0.05), compared with each monotherapy, indicating a synergistic effect of both therapies. Histidine 78-81 annexin A5 Mus musculus 82-92 22045708-11 2011 CONCLUSION: (99m)Tc-(CO)(3) His-annexin A5 micro-SPECT demonstrates increased antitumor activity of irinotecan during the transient vascular normalization period caused by bevacizumab. Histidine 28-31 annexin A5 Mus musculus 32-42 21693190-3 2011 In this study, full length SINV nsP1 was expressed in a soluble form with an N-terminal histidine tag in Escherichia coli and purified to homogeneity. Histidine 88-97 SH2 domain containing 3A Homo sapiens 32-36 21746768-3 2011 About one third of these enzymes belong to the secreted PLA(2) (sPLA(2)) family, which comprises low molecular weight, Ca(2+) requiring, secreted enzymes with a His/Asp catalytic dyad. Histidine 161-164 phospholipase A2, group IB, pancreas Mus musculus 56-62 21746768-3 2011 About one third of these enzymes belong to the secreted PLA(2) (sPLA(2)) family, which comprises low molecular weight, Ca(2+) requiring, secreted enzymes with a His/Asp catalytic dyad. Histidine 161-164 phospholipase A2, group IIA (platelets, synovial fluid) Mus musculus 64-71 21882401-0 2004 3-Cyano-4-[(18)F]fluoro-benzoyl-Ala(SO3H)-Ala(SO3H)-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2 The amphibian bombesin (BBN or BN, a peptide of 14 amino acids) is an analog of human gastrin-releasing peptide (GRP, a peptide of 27 amino acids), which binds to the GRP receptor (GRPR) with high affinity and specificity (1). Histidine 79-82 gastrin releasing peptide Homo sapiens 109-117 21882401-0 2004 3-Cyano-4-[(18)F]fluoro-benzoyl-Ala(SO3H)-Ala(SO3H)-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2 The amphibian bombesin (BBN or BN, a peptide of 14 amino acids) is an analog of human gastrin-releasing peptide (GRP, a peptide of 27 amino acids), which binds to the GRP receptor (GRPR) with high affinity and specificity (1). Histidine 79-82 gastrin releasing peptide Homo sapiens 181-206 21882401-0 2004 3-Cyano-4-[(18)F]fluoro-benzoyl-Ala(SO3H)-Ala(SO3H)-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2 The amphibian bombesin (BBN or BN, a peptide of 14 amino acids) is an analog of human gastrin-releasing peptide (GRP, a peptide of 27 amino acids), which binds to the GRP receptor (GRPR) with high affinity and specificity (1). Histidine 79-82 gastrin releasing peptide Homo sapiens 208-211 21882401-0 2004 3-Cyano-4-[(18)F]fluoro-benzoyl-Ala(SO3H)-Ala(SO3H)-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2 The amphibian bombesin (BBN or BN, a peptide of 14 amino acids) is an analog of human gastrin-releasing peptide (GRP, a peptide of 27 amino acids), which binds to the GRP receptor (GRPR) with high affinity and specificity (1). Histidine 79-82 gastrin releasing peptide Homo sapiens 262-265 21536417-2 2011 Turbidity, zeta potential and 1H NMR measurements were used to study the aggregation behaviors of His-PAsp/PAsp under different pH values. Histidine 98-101 carboxypeptidase B1 Homo sapiens 102-106 21536417-2 2011 Turbidity, zeta potential and 1H NMR measurements were used to study the aggregation behaviors of His-PAsp/PAsp under different pH values. Histidine 98-101 carboxypeptidase B1 Homo sapiens 107-111 21682270-3 2011 More importantly, in contrast to the reported nuclear stains that are based on luminescence enhancement through interaction with nucleic acids, complex LIr1 as a nuclear stain has a reaction-based mode of action, which relies on its rapid reaction with histidine/histidine-containing proteins. Histidine 253-262 leukocyte immunoglobulin like receptor B1 Homo sapiens 152-156 21682270-3 2011 More importantly, in contrast to the reported nuclear stains that are based on luminescence enhancement through interaction with nucleic acids, complex LIr1 as a nuclear stain has a reaction-based mode of action, which relies on its rapid reaction with histidine/histidine-containing proteins. Histidine 263-272 leukocyte immunoglobulin like receptor B1 Homo sapiens 152-156 21718950-2 2011 PROCEDURE: N(epsilon)-functionalized histidine derivative was coupled to the N-terminus of core peptide (CP) and HAP-1 to allow coupling of (99m)Tc-tricarbonyl linker (Isolink). Histidine 37-46 huntingtin-associated protein 1 Rattus norvegicus 113-118 21296891-5 2011 Replacement of the distal histidine by leucine or glutamine leads to a stable five-coordinated geometry; these neuroglobin mutants reduce nitrite to NO ~2000 times faster than the wild type, whereas mutation of either Cys-55 or Cys-46 to alanine stabilizes the six-coordinate structure and slows the reaction. Histidine 26-35 neuroglobin Homo sapiens 111-122 21530495-0 2011 A conserved histidine in human DNLZ/HEP is required for stimulation of HSPA9 ATPase activity. Histidine 12-21 DNL-type zinc finger Homo sapiens 31-35 21530495-6 2011 These findings implicate a conserved histidine as critical for DNLZ regulation of mitochondrial HSPA9 catalytic activity. Histidine 37-46 DNL-type zinc finger Homo sapiens 63-67 21377473-8 2011 We propose a model of the tetrahedral coordination of a Zn(2+) by (Cys)(3)His residues that is compatible with SS2 formation in S100A3. Histidine 74-77 butyrophilin like 2 Homo sapiens 111-114 21502511-2 2011 Aprataxin exhibits homology to the histidine triad superfamily of nucleotide hydrolases and transferases and removes 5"-adenylate groups from DNA that arise from aborted ligation reactions. Histidine 35-44 aprataxin Homo sapiens 0-9 21563331-0 2004 (68)Ga-DOTA-4-amino-1-carboxymethyl-piperidine-D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2 The amphibian bombesin (BBN or BN, a peptide of 14 amino acids) is an analog of human gastrin-releasing peptide (GRP, a peptide of 27 amino acids) that binds to GRP receptor (GRPR) with high affinity and specificity (1). Histidine 73-76 gastrin releasing peptide Homo sapiens 103-111 21563331-0 2004 (68)Ga-DOTA-4-amino-1-carboxymethyl-piperidine-D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2 The amphibian bombesin (BBN or BN, a peptide of 14 amino acids) is an analog of human gastrin-releasing peptide (GRP, a peptide of 27 amino acids) that binds to GRP receptor (GRPR) with high affinity and specificity (1). Histidine 73-76 gastrin releasing peptide Homo sapiens 175-200 21563331-0 2004 (68)Ga-DOTA-4-amino-1-carboxymethyl-piperidine-D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2 The amphibian bombesin (BBN or BN, a peptide of 14 amino acids) is an analog of human gastrin-releasing peptide (GRP, a peptide of 27 amino acids) that binds to GRP receptor (GRPR) with high affinity and specificity (1). Histidine 73-76 gastrin releasing peptide Homo sapiens 202-205 21343298-8 2011 The E-loop of Nox4 but not Nox1 and Nox2 contains a highly conserved histidine that could serve as a source for protons to accelerate spontaneous dismutation of superoxide to form H(2)O(2). Histidine 69-78 cytochrome b-245 beta chain Homo sapiens 36-40 21428382-0 2011 Histidine E7 dynamics modulates ligand exchange between distal pocket and solvent in AHb1 from Arabidopsis thaliana. Histidine 0-9 hemoglobin 1 Arabidopsis thaliana 85-89 21428382-6 2011 Overall, these findings provide evidence supporting the functional implications of the conformational rearrangement found for the distal His in AHb1, which mimics the gating role proposed for the same residue in myoglobin. Histidine 137-140 hemoglobin 1 Arabidopsis thaliana 144-148 21228277-3 2011 The C-terminal catalytic domain is similar to UfSP1 with Cys(294), Asp(418), His(420), Tyr(282), and a regulatory loop participating in catalysis. Histidine 77-80 UFM1-specific peptidase 1 Mus musculus 46-51 21156191-2 2011 The new allele was identical to HLA-G*01:06 at exons 2, 3, and 4 with the exception of a base pair substitution at codon 169 (CAC CGC) resulting in a coding change from histidine to arginine and codon 171 (TAC CAC), resulting in turn in a coding change from tyrosine to histidine. Histidine 171-180 major histocompatibility complex, class I, G Homo sapiens 32-37 21156191-2 2011 The new allele was identical to HLA-G*01:06 at exons 2, 3, and 4 with the exception of a base pair substitution at codon 169 (CAC CGC) resulting in a coding change from histidine to arginine and codon 171 (TAC CAC), resulting in turn in a coding change from tyrosine to histidine. Histidine 274-283 major histocompatibility complex, class I, G Homo sapiens 32-37 20641535-0 2004 (111)In-DOTA-Gly-benzoyl-D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2 The amphibian bombesin (BBN or BN, a peptide of 14 amino acids) is an analog of human gastrin-releasing peptide (GRP, a peptide of 27 amino acids) that binds to GRP receptors (GRPR) with high affinity and specificity (1). Histidine 51-54 gastrin releasing peptide Homo sapiens 81-89 20937357-2 2011 Previously we have found that a C-terminal His(6)-tag destroys the bioactivity of growth differentiation-9 (GDF9, a homolog of BMP15). Histidine 43-46 growth differentiation factor 9 Homo sapiens 82-106 20937357-2 2011 Previously we have found that a C-terminal His(6)-tag destroys the bioactivity of growth differentiation-9 (GDF9, a homolog of BMP15). Histidine 43-46 growth differentiation factor 9 Homo sapiens 108-112 21290627-0 2004 3-Cyano-4-[(18)F]fluoro-benzoyl-Ala(SO3H)-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2 3-Cyano-4-[(18)F]fluoro-benzoyl-Ala(SO3H)-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2, abbreviated as [(18)F]7b, is a bombesin (BN)-based (18)F-labeled peptide synthesized by Mu et al. Histidine 154-157 gastrin releasing peptide Homo sapiens 202-210 20978135-3 2011 We have previously shown that Fra2 and Grx3/4 form a [2Fe-2S](2+)-bridged heterodimeric complex with iron ligands provided by the active site cysteine of Grx3/4, glutathione, and a histidine residue. Histidine 181-190 Bol2p Saccharomyces cerevisiae S288C 30-34 20978135-3 2011 We have previously shown that Fra2 and Grx3/4 form a [2Fe-2S](2+)-bridged heterodimeric complex with iron ligands provided by the active site cysteine of Grx3/4, glutathione, and a histidine residue. Histidine 181-190 monothiol glutaredoxin GRX3 Saccharomyces cerevisiae S288C 39-43 20978135-3 2011 We have previously shown that Fra2 and Grx3/4 form a [2Fe-2S](2+)-bridged heterodimeric complex with iron ligands provided by the active site cysteine of Grx3/4, glutathione, and a histidine residue. Histidine 181-190 monothiol glutaredoxin GRX3 Saccharomyces cerevisiae S288C 154-158 20978135-5 2011 Here, we present spectroscopic evidence that His-103 in Fra2 is an Fe-S cluster ligand in the Fra2-Grx3 complex. Histidine 45-48 Bol2p Saccharomyces cerevisiae S288C 56-60 20978135-5 2011 Here, we present spectroscopic evidence that His-103 in Fra2 is an Fe-S cluster ligand in the Fra2-Grx3 complex. Histidine 45-48 Bol2p Saccharomyces cerevisiae S288C 94-98 20978135-5 2011 Here, we present spectroscopic evidence that His-103 in Fra2 is an Fe-S cluster ligand in the Fra2-Grx3 complex. Histidine 45-48 monothiol glutaredoxin GRX3 Saccharomyces cerevisiae S288C 99-103 20978135-7 2011 In vivo genetic studies further confirm that Fra2 His-103 is critical for control of Aft1 activity in response to the cellular iron status. Histidine 50-53 Bol2p Saccharomyces cerevisiae S288C 45-49 20978135-7 2011 In vivo genetic studies further confirm that Fra2 His-103 is critical for control of Aft1 activity in response to the cellular iron status. Histidine 50-53 DNA-binding transcription factor AFT1 Saccharomyces cerevisiae S288C 85-89 20978135-9 2011 Taken together, these results demonstrate that the histidine coordination and stability of the [2Fe-2S] cluster in the Fra2-Grx3 complex are essential for iron regulation in yeast. Histidine 51-60 Bol2p Saccharomyces cerevisiae S288C 119-123 20978135-9 2011 Taken together, these results demonstrate that the histidine coordination and stability of the [2Fe-2S] cluster in the Fra2-Grx3 complex are essential for iron regulation in yeast. Histidine 51-60 monothiol glutaredoxin GRX3 Saccharomyces cerevisiae S288C 124-128 21170982-7 2011 To deplete the antigen from the eluted sample, IMAC spin columns were utilized to bind the N-terminal His-tag of the antigens. Histidine 102-105 C-C motif chemokine ligand 26 Homo sapiens 47-51 21325825-1 2011 The glutamine transporter SNAT3 (SLC38A3), which also transports asparagine and histidine, exchanges sodium for protons, and displays a non-stoichiometrical conductance, which is suppressed by the catalytic activity of carbonic anhydrase II (CAII). Histidine 80-89 solute carrier family 38, member 3 Rattus norvegicus 26-31 21325825-1 2011 The glutamine transporter SNAT3 (SLC38A3), which also transports asparagine and histidine, exchanges sodium for protons, and displays a non-stoichiometrical conductance, which is suppressed by the catalytic activity of carbonic anhydrase II (CAII). Histidine 80-89 solute carrier family 38, member 3 Rattus norvegicus 33-40 20666624-3 2011 We observed that patients with the ITGAM His/His and Arg/His genotypes displayed a 1.811-fold increased risk of SLE incidence (95% confidence intervals [95% CI] = 1.171-2.802, p = 0.0089). Histidine 41-44 integrin subunit alpha M Homo sapiens 35-40 20666624-3 2011 We observed that patients with the ITGAM His/His and Arg/His genotypes displayed a 1.811-fold increased risk of SLE incidence (95% confidence intervals [95% CI] = 1.171-2.802, p = 0.0089). Histidine 45-48 integrin subunit alpha M Homo sapiens 35-40 20666624-3 2011 We observed that patients with the ITGAM His/His and Arg/His genotypes displayed a 1.811-fold increased risk of SLE incidence (95% confidence intervals [95% CI] = 1.171-2.802, p = 0.0089). Histidine 45-48 integrin subunit alpha M Homo sapiens 35-40 20666624-4 2011 Odds ratio (OR) for the homozygous ITGAM His/His genotype was 7.333 (95% CI = 0.8119-66.241, p = 0.0576). Histidine 41-44 integrin subunit alpha M Homo sapiens 35-40 20666624-4 2011 Odds ratio (OR) for the homozygous ITGAM His/His genotype was 7.333 (95% CI = 0.8119-66.241, p = 0.0576). Histidine 45-48 integrin subunit alpha M Homo sapiens 35-40 20666624-6 2011 There was an association of the ITGAM His/His and Arg/His genotypes with the occurrence of arthritis OR = 3.486 (95% CI = 1.619-7.508, p = 0.0015). Histidine 38-41 integrin subunit alpha M Homo sapiens 32-37 20666624-6 2011 There was an association of the ITGAM His/His and Arg/His genotypes with the occurrence of arthritis OR = 3.486 (95% CI = 1.619-7.508, p = 0.0015). Histidine 42-45 integrin subunit alpha M Homo sapiens 32-37 20666624-6 2011 There was an association of the ITGAM His/His and Arg/His genotypes with the occurrence of arthritis OR = 3.486 (95% CI = 1.619-7.508, p = 0.0015). Histidine 42-45 integrin subunit alpha M Homo sapiens 32-37 20666624-7 2011 We also observed an association between the ITGAM His/His and Arg/His genotypes and renal symptoms in the course of SLE OR = 2.975 (95% CI = 1.478-5.988; p = 0.0023). Histidine 50-53 integrin subunit alpha M Homo sapiens 44-49 20666624-7 2011 We also observed an association between the ITGAM His/His and Arg/His genotypes and renal symptoms in the course of SLE OR = 2.975 (95% CI = 1.478-5.988; p = 0.0023). Histidine 54-57 integrin subunit alpha M Homo sapiens 44-49 20666624-7 2011 We also observed an association between the ITGAM His/His and Arg/His genotypes and renal symptoms in the course of SLE OR = 2.975 (95% CI = 1.478-5.988; p = 0.0023). Histidine 54-57 integrin subunit alpha M Homo sapiens 44-49 22191059-4 2011 Asp1 does not bind to Cu(II) if three His residues are attached nor to any Cu(I) species to which one or more His residues are bound. Histidine 38-41 beta-secretase 2 Homo sapiens 0-4 22191059-4 2011 Asp1 does not bind to Cu(II) if three His residues are attached nor to any Cu(I) species to which one or more His residues are bound. Histidine 110-113 beta-secretase 2 Homo sapiens 0-4 21980421-3 2011 Currently, Glu314, Ser346, Lys347 and Lys362 in human c-NADP-ME were changed to the corresponding residues of human m-NAD(P)-ME (Glu, Lys, Tyr and Gln, respectively) or Ascaris suum m-NAD-ME (Ala, Ile, Asp and His, respectively). Histidine 210-213 malic enzyme 1 Homo sapiens 56-63 21446168-3 2011 Plasmid pFastBacHTb-Hsp70 containing sequence coding HSP70 gene with insertion of 6 histidine residues in protein reading frame was constructed. Histidine 84-93 heat shock protein family A (Hsp70) member 4 Homo sapiens 20-25 20966079-2 2010 The severe metal ion substrate inhibition observed during in vitro studies of the purified enzyme is almost completely eliminated by mutation of an active site histidine residue (His-287, murine ferrochelatase numbering) to leucine and reduced over 2 orders of magnitude by mutation of a nearby conserved phenylalanine residue (Phe-283) to leucine. Histidine 160-169 ferrochelatase Mus musculus 195-209 20966079-2 2010 The severe metal ion substrate inhibition observed during in vitro studies of the purified enzyme is almost completely eliminated by mutation of an active site histidine residue (His-287, murine ferrochelatase numbering) to leucine and reduced over 2 orders of magnitude by mutation of a nearby conserved phenylalanine residue (Phe-283) to leucine. Histidine 179-182 ferrochelatase Mus musculus 195-209 20667476-7 2010 To this end, we developed procedures for higher level expression in insect cells of active recombinant CHK with a hexa-histidine tag attached to its C-terminus (referred to as CHK-His(6)) and its rapid purification by a two-step method. Histidine 180-183 megakaryocyte-associated tyrosine kinase Homo sapiens 103-106 20667476-7 2010 To this end, we developed procedures for higher level expression in insect cells of active recombinant CHK with a hexa-histidine tag attached to its C-terminus (referred to as CHK-His(6)) and its rapid purification by a two-step method. Histidine 180-183 megakaryocyte-associated tyrosine kinase Homo sapiens 176-179 20667476-8 2010 Analyses by size-exclusion column chromatography and analytical ultracentrifugation revealed that the purified CHK-His(6) exists as a monomeric species in solution. Histidine 115-118 megakaryocyte-associated tyrosine kinase Homo sapiens 111-114 20667476-9 2010 Biochemical analyses demonstrated that CHK-His(6) exhibits efficiencies comparable to those of CSK in phosphorylating artificial protein and peptide substrates as well as an intact SFK protein. Histidine 43-46 megakaryocyte-associated tyrosine kinase Homo sapiens 39-42 20667476-10 2010 Our results indicate that the recombinant CHK-His(6) can be used for future studies to decipher the three-dimensional structure, and regulatory and catalytic properties of CHK. Histidine 46-49 megakaryocyte-associated tyrosine kinase Homo sapiens 42-45 20667476-10 2010 Our results indicate that the recombinant CHK-His(6) can be used for future studies to decipher the three-dimensional structure, and regulatory and catalytic properties of CHK. Histidine 46-49 megakaryocyte-associated tyrosine kinase Homo sapiens 172-175 21139689-9 2010 SDS-PAGE analysis exhibited autodegradation products with Mr of 22, 27 and 30 kDa, which on partial NH2-terminal sequencing showed cleavage of Lys17-Met18, Gln4-Ala5 and Thr-Gly (in the NH2-terminal His-tag region) bonds, respectively. Histidine 199-202 MMS19 homolog, cytosolic iron-sulfur assembly component Homo sapiens 149-154 21055628-6 2010 [(99m)Tc]-(CO)(3) His-annexin A5 was also evaluated for in vivo imaging of spontaneous apoptosis in Colo205-bearing mice (n=12). Histidine 18-21 annexin A5 Mus musculus 22-32 21055628-9 2010 [(99m)Tc]-(CO)(3) His-annexin A5 rapidly cleared from the blood and predominantly accumulated in the kidneys. Histidine 18-21 annexin A5 Mus musculus 22-32 21055628-12 2010 Spontaneous apoptosis in Colo205-bearing mice was visualised by [(99m)Tc]-(CO)(3) His-annexin A5 SPECT and correlated well with caspase-3 immunostaining (R=0.867, P<.01). Histidine 82-85 annexin A5 Mus musculus 86-96 21085509-3 2010 Previously, in our group, amino acid based amphiphiles i.e. Gly-Gly-His-EO2-Alk, a trimodular amphiphile (containing three domains: H-bond donor and acceptor/hydrophilic/hydrophobic domain, respectively) were reported to act as hydrogelators and that the gelation properties were related to hydrogen bonding, hydrophobic interactions and pi-pi stacking. Histidine 68-71 ALK receptor tyrosine kinase Homo sapiens 76-79 20811687-4 2010 In this study, human NKG2F recombinant expression in E. coli was carried out by using pET-28a with a hexahistidine (6x His) tag and a thrombin digestion sequence to the N-terminus of the recombinant protein NKG2F. Histidine 119-122 killer cell lectin like receptor C4 Homo sapiens 21-26 21567851-5 2010 A fusion protein, malate dehydrogenase-green fluorescent protein with a histidine affinity tag (MGH), is used throughout the semester. Histidine 72-81 malic enzyme 1 Homo sapiens 18-38 20806985-4 2010 The hypothesis is based on published in vitro observations that the human dopamine transporter contains a high-affinity zinc binding site (His-193, His-375, Glu-396) on its extracellular face that modulates transporter function, and in vivo studies suggesting that response to stimulants is reduced in zinc-deficient ADHD patients. Histidine 139-142 solute carrier family 6 member 3 Homo sapiens 74-94 20806985-4 2010 The hypothesis is based on published in vitro observations that the human dopamine transporter contains a high-affinity zinc binding site (His-193, His-375, Glu-396) on its extracellular face that modulates transporter function, and in vivo studies suggesting that response to stimulants is reduced in zinc-deficient ADHD patients. Histidine 148-151 solute carrier family 6 member 3 Homo sapiens 74-94 20541267-4 2010 L-His reacts faster than the other N-donor nucleophiles in the reaction with [AuCl(2)(en)](+), but in the reaction with [AuCl(2)(SMC)] 5"-GMP is the best nucleophile. Histidine 0-5 5'-nucleotidase, cytosolic II Homo sapiens 138-141 20530481-8 2010 To analyze linkage to hydrolytic activity, we introduced several point mutations and show that residues His(114) and His(133) are essential for PON2 activity. Histidine 104-107 paraoxonase 2 Homo sapiens 144-148 20530481-8 2010 To analyze linkage to hydrolytic activity, we introduced several point mutations and show that residues His(114) and His(133) are essential for PON2 activity. Histidine 117-120 paraoxonase 2 Homo sapiens 144-148 20693691-0 2010 Structural basis of the histidine-mediated vitamin D receptor agonistic and antagonistic mechanisms of (23S)-25-dehydro-1alpha-hydroxyvitamin D3-26,23-lactone. Histidine 24-33 vitamin D receptor Homo sapiens 43-61 20544958-1 2010 The C-terminal three-Cys(2)His(2) zinc-finger domain (TZD) of mouse testis zinc-finger protein binds to the 5"-TGTACAGTGT-3" at the Aie1 (aurora-C) promoter with high specificity. Histidine 27-30 aurora kinase C Mus musculus 132-136 19432810-4 2010 Immunochemical staining with anti-His revealed that TAT-aFGF-His proteins were readily found in the retina (mainly in the ganglion cell layer) at 30 min. Histidine 34-37 fibroblast growth factor 1 Rattus norvegicus 56-60 19432810-8 2010 After IR injury, retina from TAT-aFGF-His-treated rats showed better-maintained inner retinal layer structure, reduced apoptosis of retinal ganglion cells and improved retinal function compared to those treated with aFGF-His or PBS. Histidine 38-41 fibroblast growth factor 1 Rattus norvegicus 33-37 19432810-8 2010 After IR injury, retina from TAT-aFGF-His-treated rats showed better-maintained inner retinal layer structure, reduced apoptosis of retinal ganglion cells and improved retinal function compared to those treated with aFGF-His or PBS. Histidine 38-41 fibroblast growth factor 1 Rattus norvegicus 216-220 19432810-8 2010 After IR injury, retina from TAT-aFGF-His-treated rats showed better-maintained inner retinal layer structure, reduced apoptosis of retinal ganglion cells and improved retinal function compared to those treated with aFGF-His or PBS. Histidine 221-224 fibroblast growth factor 1 Rattus norvegicus 33-37 19432810-9 2010 These results indicate that conjugation of TAT to aFGF-His can markedly improve the ability of aFGF-His to penetrate the ocular barrier without impairing its biological function. Histidine 55-58 fibroblast growth factor 1 Rattus norvegicus 50-54 19432810-9 2010 These results indicate that conjugation of TAT to aFGF-His can markedly improve the ability of aFGF-His to penetrate the ocular barrier without impairing its biological function. Histidine 55-58 fibroblast growth factor 1 Rattus norvegicus 95-99 20403435-1 2010 In the nuclear receptor of vitamin D (VDR) histidine 305 participates to the anchoring of the ligand. Histidine 43-52 vitamin D receptor Homo sapiens 38-41 20598110-2 2010 Comparison of the substrate-binding site of PRCP with that of its family partner, dipeptidyl dipeptidase 7 (DPP7), helps to explain the different enzymatic activities of these structurally similar proteins, and also reveals a novel apparent charge-relay system in PRCP involving the active-site catalytic histidine. Histidine 305-314 prolylcarboxypeptidase Homo sapiens 44-48 20598110-2 2010 Comparison of the substrate-binding site of PRCP with that of its family partner, dipeptidyl dipeptidase 7 (DPP7), helps to explain the different enzymatic activities of these structurally similar proteins, and also reveals a novel apparent charge-relay system in PRCP involving the active-site catalytic histidine. Histidine 305-314 prolylcarboxypeptidase Homo sapiens 264-268 20540760-4 2010 PRCP contains an alpha/beta hydrolase domain harboring the catalytic Asp-His-Ser triad and a novel helical structural domain that caps the active site. Histidine 73-76 prolylcarboxypeptidase Homo sapiens 0-4 20347923-1 2010 Among the emerging phospholipase A(2) (PLA(2)) superfamily, the secreted PLA(2) (sPLA(2)) family consists of low-molecular-mass, Ca(2+)-requiring extracellular enzymes with a His-Asp catalytic dyad. Histidine 175-178 phospholipase A2, group IB, pancreas Mus musculus 19-37 20347923-1 2010 Among the emerging phospholipase A(2) (PLA(2)) superfamily, the secreted PLA(2) (sPLA(2)) family consists of low-molecular-mass, Ca(2+)-requiring extracellular enzymes with a His-Asp catalytic dyad. Histidine 175-178 phospholipase A2, group IB, pancreas Mus musculus 39-45 20347923-1 2010 Among the emerging phospholipase A(2) (PLA(2)) superfamily, the secreted PLA(2) (sPLA(2)) family consists of low-molecular-mass, Ca(2+)-requiring extracellular enzymes with a His-Asp catalytic dyad. Histidine 175-178 phospholipase A2, group IB, pancreas Mus musculus 73-79 20347923-1 2010 Among the emerging phospholipase A(2) (PLA(2)) superfamily, the secreted PLA(2) (sPLA(2)) family consists of low-molecular-mass, Ca(2+)-requiring extracellular enzymes with a His-Asp catalytic dyad. Histidine 175-178 phospholipase A2, group IIA (platelets, synovial fluid) Mus musculus 81-88 20404097-2 2010 We show that Snf1 promotes the formation of phosphorylated alpha subunit of eukaryotic translation initiation factor 2 (eIF2alpha-P), a regulator of general and gene-specific translation, by stimulating the function of eIF2alpha kinase Gcn2 during histidine starvation of glucose-grown cells. Histidine 248-257 eukaryotic translation initiation factor 2A Homo sapiens 120-129 20404097-2 2010 We show that Snf1 promotes the formation of phosphorylated alpha subunit of eukaryotic translation initiation factor 2 (eIF2alpha-P), a regulator of general and gene-specific translation, by stimulating the function of eIF2alpha kinase Gcn2 during histidine starvation of glucose-grown cells. Histidine 248-257 eukaryotic translation initiation factor 2A Homo sapiens 219-228 20684318-4 2010 The expression of the fusion protein HIS-annexin 5 was induced by isopropyl-beta-D-thiogalactoside (IPTG) under the control of the T7 promoter, and the products were purified by affinity chromatography. Histidine 37-40 annexin A5 Rattus norvegicus 41-50 20188155-1 2010 Thyrotropin-releasing hormone (TRH, pGlu-His-Pro-NH(2)) and the structurally related [Glu(2)]TRH (pGlu-Glu-Pro-NH(2)) are endogenous peptides with a plethora of actions in the central nervous system. Histidine 41-44 thyrotropin releasing hormone Mus musculus 0-29 20421979-4 2010 METHODOLOGY/PRINCIPAL FINDINGS: We produced a transgenic mouse line which expresses His-tagged IZUMO1 in the Izumo1(-/-) genetic background. Histidine 84-87 izumo sperm-egg fusion 1 Mus musculus 95-101 20421979-4 2010 METHODOLOGY/PRINCIPAL FINDINGS: We produced a transgenic mouse line which expresses His-tagged IZUMO1 in the Izumo1(-/-) genetic background. Histidine 84-87 izumo sperm-egg fusion 1 Mus musculus 109-115 20421979-5 2010 After solubilization of sperm membranes, we purified His-tagged IZUMO1 using anti-His affinity chromatography and found a protein that interacts with IZUMO1. Histidine 53-56 izumo sperm-egg fusion 1 Mus musculus 64-70 20421979-5 2010 After solubilization of sperm membranes, we purified His-tagged IZUMO1 using anti-His affinity chromatography and found a protein that interacts with IZUMO1. Histidine 53-56 izumo sperm-egg fusion 1 Mus musculus 150-156 20421979-5 2010 After solubilization of sperm membranes, we purified His-tagged IZUMO1 using anti-His affinity chromatography and found a protein that interacts with IZUMO1. Histidine 82-85 izumo sperm-egg fusion 1 Mus musculus 64-70 20421979-5 2010 After solubilization of sperm membranes, we purified His-tagged IZUMO1 using anti-His affinity chromatography and found a protein that interacts with IZUMO1. Histidine 82-85 izumo sperm-egg fusion 1 Mus musculus 150-156 19800635-7 2010 The interaction of SES x 5HIAA was a significant predictor of levels of CD11b and CD11c expression (p=.02, and p=.05, respectively); the mean CD11b difference between Hi and Lo SES subjects was significant (p=.003) only in those with Lo levels of 5HIAA, while SES differences in CD11b among those with Mid and Hi levels of 5HIAA did not vary statistically. Histidine 167-169 integrin subunit alpha M Homo sapiens 142-147 19800635-7 2010 The interaction of SES x 5HIAA was a significant predictor of levels of CD11b and CD11c expression (p=.02, and p=.05, respectively); the mean CD11b difference between Hi and Lo SES subjects was significant (p=.003) only in those with Lo levels of 5HIAA, while SES differences in CD11b among those with Mid and Hi levels of 5HIAA did not vary statistically. Histidine 167-169 integrin subunit alpha M Homo sapiens 142-147 20050619-0 2010 Nonadiabatic histidine dissociation of hexacoordinate heme in neuroglobin protein. Histidine 13-22 neuroglobin Homo sapiens 62-73 20050619-1 2010 In the present work, density functional theory and canonical nonadiabatic Monte Carlo transition state theory have been used to investigate the histidine dissociation process from hexacoordinate heme in Ngb protein. Histidine 144-153 neuroglobin Homo sapiens 203-206 19723023-8 2010 With detraining in the HI group, CD34+ cells declined 44 %, and the percentage change in CD34+/VEGFR2+ cells was positively correlated with the change in FBF response to reactive hyperaemia. Histidine 23-25 kinase insert domain receptor Homo sapiens 95-101 20798512-4 2010 Phosphorylation of GCN2 kinase and its substrate eIF2alpha was induced by histidine deprivation. Histidine 74-83 eukaryotic translation initiation factor 2 alpha kinase 4 Homo sapiens 19-23 20798512-4 2010 Phosphorylation of GCN2 kinase and its substrate eIF2alpha was induced by histidine deprivation. Histidine 74-83 eukaryotic translation initiation factor 2A Homo sapiens 49-58 20798512-8 2010 Histidine deprivation as well as activation of GCN2 by treatment with tRNA, caused an increase in LX-2 cell viability, suggesting amino acid restriction to present a protective effect in HSC which is mediated by GCN2 activation. Histidine 0-9 eukaryotic translation initiation factor 2 alpha kinase 4 Homo sapiens 212-216 19801650-3 2009 The 1,25D-hVDR structure-function studies demonstrate that 1) van der Waals contacts between helix-12 residues Leu-414 and Val-418 and 1,25D enhance the stability of the closed helix-12 conformer and 2) removal of the side-chain H-bonds to His-305(F) and/or His-397(F) have no effect on 1,25D transactivation, even though they reduce the binding affinity of 1,25D. Histidine 240-243 vitamin D receptor Homo sapiens 10-14 19801650-3 2009 The 1,25D-hVDR structure-function studies demonstrate that 1) van der Waals contacts between helix-12 residues Leu-414 and Val-418 and 1,25D enhance the stability of the closed helix-12 conformer and 2) removal of the side-chain H-bonds to His-305(F) and/or His-397(F) have no effect on 1,25D transactivation, even though they reduce the binding affinity of 1,25D. Histidine 258-261 vitamin D receptor Homo sapiens 10-14 19786305-5 2009 Both peptides show a synchrotron radiation (SR) CD-pattern resembling to that of the polyproline II structure, similarly to that of the His-Pro-rich domain of the HRG protein. Histidine 136-139 histidine rich glycoprotein Homo sapiens 163-166 19720102-1 2009 We found that beta-lactotensin (His-Ile-Arg-Leu), which has been isolated as an ileum-contracting peptide from chymotrypsin digest of bovine beta-lactoglobulin, dose-dependently suppresses food intake after intracerebroventricular (i.c.v.) Histidine 32-35 beta-lactoglobulin Bos taurus 141-159 19754350-8 2009 Arg-His-Arg haplotype of XRCC1 significantly enhanced the risk for hepatitis by 2.8-folds (p = 0.001), but not for HCC (odds ratio = 1.5; p = 0.28). Histidine 4-7 X-ray repair cross complementing 1 Homo sapiens 25-30 19843177-7 2009 In addition, the structure of a new class of lipid with a histidine head group, found in all of the strains of flies, but lower in Maroon Like, was elucidated. Histidine 58-67 maroon-like Drosophila melanogaster 131-142 19757795-2 2009 In order to model the syn disposition of histidine residues in carboxylate-bridged non-heme diiron enzymes, we prepared a new dinucleating ligand, H(2)BPG(2)DEV, that provides this geometric feature. Histidine 41-50 synemin Homo sapiens 22-25 20641903-4 2004 GRP and BN share an identical C-terminal region (-Trp-Ala-Val-Gly-His-Leu-Met-NH2), which is necessary for receptor binding and signal transduction (5, 6). Histidine 66-69 gastrin releasing peptide Homo sapiens 0-3 20641937-2 2004 Bombesin (BN) is an amphibian neuropeptide consisting of 14 amino acids (pGlu-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2) (2, 3), first isolated from frog skin in 1970 (4). Histidine 118-121 gastrin releasing peptide Homo sapiens 0-8 20641937-4 2004 GRP and BN share an identical C-terminal region (-Trp-Ala-Val-Gly-His-Leu-Met-NH2), which is necessary for receptor binding and signal transduction (5, 6). Histidine 66-69 gastrin releasing peptide Homo sapiens 0-3 19546227-5 2009 Strains were starved for histidine, leucine, or tryptophan and shown to rapidly induce Gcn2p phosphorylation of eIF2. Histidine 25-34 serine/threonine-protein kinase GCN2 Saccharomyces cerevisiae S288C 87-92 19487247-0 2009 Influence of N-terminal domain histidine and proline residues on the substrate selectivities of human UDP-glucuronosyltransferase 1A1, 1A6, 1A9, 2B7, and 2B10. Histidine 31-40 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 102-133 19487247-1 2009 An N-terminal domain histidine [corresponding to position 39 of UDP-glucuronosyltransferase (UGT) 1A1] is conserved in all UGT1A and UGT2B subfamily proteins except UGT1A4 (Pro-40) and UGT2B10 (Leu-34). Histidine 21-30 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 64-101 19487247-5 2009 The conserved N-terminal domain histidine of UGT1A1, UGT1A6, UGT1A9, and UGT2B7 was mutated to proline and leucine 34 of UGT2B10 was substituted with histidine, and the capacity of the wild-type and mutant proteins to glucuronidate 4MU, 1NP, LTG, TFP, and naproxen was characterized. Histidine 32-41 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 45-51 19487247-5 2009 The conserved N-terminal domain histidine of UGT1A1, UGT1A6, UGT1A9, and UGT2B7 was mutated to proline and leucine 34 of UGT2B10 was substituted with histidine, and the capacity of the wild-type and mutant proteins to glucuronidate 4MU, 1NP, LTG, TFP, and naproxen was characterized. Histidine 32-41 UDP glucuronosyltransferase family 2 member B7 Homo sapiens 73-79 19487247-5 2009 The conserved N-terminal domain histidine of UGT1A1, UGT1A6, UGT1A9, and UGT2B7 was mutated to proline and leucine 34 of UGT2B10 was substituted with histidine, and the capacity of the wild-type and mutant proteins to glucuronidate 4MU, 1NP, LTG, TFP, and naproxen was characterized. Histidine 150-159 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 45-51 19487247-5 2009 The conserved N-terminal domain histidine of UGT1A1, UGT1A6, UGT1A9, and UGT2B7 was mutated to proline and leucine 34 of UGT2B10 was substituted with histidine, and the capacity of the wild-type and mutant proteins to glucuronidate 4MU, 1NP, LTG, TFP, and naproxen was characterized. Histidine 150-159 UDP glucuronosyltransferase family 2 member B7 Homo sapiens 73-79 19505476-5 2009 FH became more elongated at pH 9.4, showing the involvement of histidine residue(s) in its folded-back structure. Histidine 63-72 complement factor H Homo sapiens 0-2 19272353-1 2009 The mitochondrial carnitine/acylcarnitine carrier (CAC) of Rattus norvegicus contains two His, His-29 and His-205. Histidine 90-93 solute carrier family 25 member 20 Rattus norvegicus 4-55 19272353-1 2009 The mitochondrial carnitine/acylcarnitine carrier (CAC) of Rattus norvegicus contains two His, His-29 and His-205. Histidine 95-98 solute carrier family 25 member 20 Rattus norvegicus 4-55 19272353-1 2009 The mitochondrial carnitine/acylcarnitine carrier (CAC) of Rattus norvegicus contains two His, His-29 and His-205. Histidine 95-98 solute carrier family 25 member 20 Rattus norvegicus 4-55 19272353-3 2009 In the homology model of CAC, His-29 is located in H1 close to the bottom of the central cavity. Histidine 30-33 solute carrier family 25 member 20 Rattus norvegicus 25-28 19272353-10 2009 The substitution of His-205 led to a change of response of the CAC to the pH. Histidine 20-23 solute carrier family 25 member 20 Rattus norvegicus 63-66 19272353-11 2009 The results are discussed in terms of relationships of His-29 with the molecular mechanism of translocation of the CAC. Histidine 55-58 solute carrier family 25 member 20 Rattus norvegicus 115-118 18597497-7 2008 Recombinant CBR underwent irreversible inhibition during QM exposure, and mass spectrometry was utilized to identify alkylation sites at Cys 51, Lys 17, Lys 189, Lys 201, His 28, and His 204. Histidine 183-186 carbonyl reductase 1 Mus musculus 12-15 18485777-3 2008 Sequencing of the PNPO gene revealed a novel homozygous c.284G>A transition in exon 3, resulting in arginine to histidine substitution and reduced activity of the PNPO mutant to 18% relative to the wild type. Histidine 112-121 pyridoxamine 5'-phosphate oxidase Homo sapiens 18-22 18582542-7 2008 Moreover, the reduced cytotoxicity noted with BPB-PLA2 may be partly attributed to conformational distortion after modification of His-47. Histidine 131-134 phospholipase A2 group IIA Homo sapiens 50-54 18467498-6 2008 This vector produces a fusion protein (denoted as His(6)-Smt3-X) in which the protein of interest (X) is fused to a hexahistidine (His(6))-tagged Smt3. Histidine 50-53 SUMO family protein SMT3 Saccharomyces cerevisiae S288C 57-61 18467498-6 2008 This vector produces a fusion protein (denoted as His(6)-Smt3-X) in which the protein of interest (X) is fused to a hexahistidine (His(6))-tagged Smt3. Histidine 50-53 SUMO family protein SMT3 Saccharomyces cerevisiae S288C 146-150 18276838-4 2008 Expressed and purified from bacteria using affinity chromatography, the AKR1A1 protein with a single histidine (6x-His) tag exhibited the greatest activity using two test substrates: p-nitrobenzaldehyde (5.09 +/- 0.16 micromol/min/mg of purified protein) and DL-glyceraldehyde (1.24 +/- 0.17 micromol/min/mg). Histidine 101-110 aldo-keto reductase family 1 member A1 Homo sapiens 72-78 18276838-6 2008 The 6x-His-tagged AKR1A1 wild type and allelic variants, E55D and N52S, were subsequently examined for metabolic activity using DAUN and DOX. Histidine 7-10 aldo-keto reductase family 1 member A1 Homo sapiens 18-24 18370410-2 2008 Here, we address the role of the conserved active site Ser167 residue in human IDO (S167A and S167H variants), which is replaced with a histidine in other mammalian and bacterial TDO enzymes. Histidine 136-145 tryptophan 2,3-dioxygenase Homo sapiens 179-182 18275838-0 2008 Role of Histidine-152 in cofactor orientation in the PLP-dependent O-acetylserine sulfhydrylase reaction. Histidine 8-17 proteolipid protein 1 Homo sapiens 53-56 18178100-6 2008 To determine if the presence of the C-terminal his-tag altered ACBP interactions with other proteins, direct binding to hepatocyte nuclear factor-4alpha (HNF-4alpha), a nuclear receptor regulating transcription of genes involved in lipid metabolism, was examined. Histidine 47-50 hepatic nuclear factor 4, alpha Mus musculus 154-164 18194661-7 2008 Site-directed mutagenesis of any of the four conserved histidine residues (His 50, 86, 120 and 159) to alanine resulted in much diminished levels of heme in the purified Dcytb, while mutation of the non-conserved histidine 33 had no effect on the heme content. Histidine 55-64 cytochrome b reductase 1 Homo sapiens 170-175 18194661-7 2008 Site-directed mutagenesis of any of the four conserved histidine residues (His 50, 86, 120 and 159) to alanine resulted in much diminished levels of heme in the purified Dcytb, while mutation of the non-conserved histidine 33 had no effect on the heme content. Histidine 75-78 cytochrome b reductase 1 Homo sapiens 170-175 18094146-6 2008 Replacement of histidine 26 (H26) in the NH(2) terminus with alanine eliminated the requirement of protons for channel activity and increased sensitivity to proton-induced inhibition, resulting in maximal channel activity at alkaline pH(i) and smaller whole cell currents at resting pH(i) compared with wild-type Kir7.1. Histidine 15-24 potassium inwardly rectifying channel subfamily J member 13 Homo sapiens 313-319 17583729-3 2007 We have investigated this conformational factor in the denatured state of iso-1-cytchrome c using a five alanine insert in front of a unique histidine in the N-terminal region of the protein. Histidine 141-150 eukaryotic translation initiation factor 1 Homo sapiens 74-79 17697822-6 2007 The CFH Tyr402His (rs1061170) polymorphism was determined (His(402) allele 37%), and using 3 tagging polymorphisms (rs1130864, rs1205, and rs3093068), CRP haplotypes were inferred (1 = CTC, 2 = TCC, 3 = CCC, 4 = CCG; frequencies of 33%, 32%, 30%, and 6%, respectively). Histidine 14-17 complement factor H Homo sapiens 4-7 17636946-4 2007 The deleterious effects on inhibitor potency by methylation of the anilino-triazole nitrogens, as well as the X-ray crystal structure of triazole 102 bound in the active site of MetAP2, confirm the key interactions between the triazole nitrogens, the active site cobalt atoms, and the His-231 side-chain. Histidine 285-288 methionyl aminopeptidase 2 Homo sapiens 178-184 17659281-2 2007 The structure of OTR revealed that the active site contains an unusual lysine-ligated heme, despite the presence of a CXXCH motif in the sequence that would predict histidine ligation. Histidine 165-174 tetrathionate reductase family octaheme c-type cytochrome Shewanella oneidensis MR-1 17-20 17550235-5 2007 By contrast, the BARD1 BRCT selectivity pocket P2 exhibits distinct structural features, including two prominent histidine residues, His685 and His686, which may be important for ligand binding. Histidine 113-122 BRCA1 associated RING domain 1 Homo sapiens 17-22 17438030-3 2007 To investigate the LcrV-TLR2 interaction in vitro, His-tagged recombinant LcrV (rLcrV) from Yersinia pestis was cloned and expressed in Escherichia coli and purified through Ni-nitrilotriacetic acid column chromatography. Histidine 51-54 Yop secretion and targeting control protein Yersinia pestis 19-23 17438030-3 2007 To investigate the LcrV-TLR2 interaction in vitro, His-tagged recombinant LcrV (rLcrV) from Yersinia pestis was cloned and expressed in Escherichia coli and purified through Ni-nitrilotriacetic acid column chromatography. Histidine 51-54 Yop secretion and targeting control protein Yersinia pestis 74-78 17360715-7 2007 The side chains of His/Tyr(402) have similar, solvent-exposed orientations far from interfaces with CCP6 and -8. Histidine 19-22 AGBL carboxypeptidase 4 Homo sapiens 100-104 17468887-4 2007 As described in other SCD proteins, the predicted amino acid sequence of bovine SCD5 includes four transmembrane domains and three conserved histidine motifs. Histidine 141-150 stearoyl-CoA desaturase 5 Bos taurus 80-84 17444659-1 2007 The variant of Aequorea green fluorescent protein (GFP) known as blue fluorescent protein (BFP) was originally engineered by substituting histidine for tyrosine in the chromophore precursor sequence. Histidine 138-147 ring finger protein 112 Homo sapiens 65-89 17444659-1 2007 The variant of Aequorea green fluorescent protein (GFP) known as blue fluorescent protein (BFP) was originally engineered by substituting histidine for tyrosine in the chromophore precursor sequence. Histidine 138-147 ring finger protein 112 Homo sapiens 91-94 17475008-8 2007 Molecular docking experiments identified key residues in donor and acceptor recognition and provided insight into the catalytic mechanism of UGT glucuronidation, suggesting the human UGT1A1 residue histidine 39 (H39) as a general base and the residue aspartic acid 151 (D151) as an important electron-transfer helper. Histidine 198-207 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 183-189 18690027-4 2007 We demonstrate here that the mouse RIM1 arginine-to-histidine substitution (R655H), which corresponds to the human CORD7 mutation, modifies RIM1 function in regulating VDCC currents elicited by the P/Q-type Ca(v)2.1 and L-type Ca(v)1.4 channels. Histidine 52-61 regulating synaptic membrane exocytosis 1 Homo sapiens 115-120 18690027-4 2007 We demonstrate here that the mouse RIM1 arginine-to-histidine substitution (R655H), which corresponds to the human CORD7 mutation, modifies RIM1 function in regulating VDCC currents elicited by the P/Q-type Ca(v)2.1 and L-type Ca(v)1.4 channels. Histidine 52-61 regulating synaptic membrane exocytosis 1 Homo sapiens 140-144 17287358-5 2007 Detection of a pHis containing peptide from the yeast protein, Cdc10, suggests an unexpected role for histidine phosphorylation in septin biology. Histidine 102-111 septin CDC10 Saccharomyces cerevisiae S288C 63-68 17316554-4 2007 (2004a) Biochemistry 43:1369-1375] have shown that the replacement of either methionine with histidine in the PSI of the unicellular green alga Chlamydomonas reinhardtii resulted in accumulation of A(0)(-) (in 300-ps time scale), suggesting that both the PsaA and PsaB branches are active. Histidine 93-102 photosystem I P700 chlorophyll a apoprotein A2 Chlamydomonas reinhardtii 264-268 17251580-3 2007 Mutational analysis of cysteine and histidine residues within the conserved N-terminal zinc-binding domain in NSP1 of bovine rotavirus strain B641 abolished IRF3 degradation in transfected cells. Histidine 36-45 interferon regulatory factor 3 Bos taurus 157-161 17453047-4 2007 We rewired the genome by recruiting an essential gene, HIS3, from the histidine biosynthesis pathway to a foreign regulatory system, the GAL network responsible for galactose utilization. Histidine 70-79 imidazoleglycerol-phosphate dehydratase HIS3 Saccharomyces cerevisiae S288C 55-59 17176064-1 2006 An essential histidine ligand to the electron transfer copper (CuH) of peptidylglycine alpha-hydroxylating monooxygenase (PHMcc) was mutated to an alanine and found to retain copper binding and hydroxylase activity [Jaron, S., et al. Histidine 13-22 peptidylglycine alpha-amidating monooxygenase Homo sapiens 71-120 17027633-2 2006 We modeled one mutation in human cTnI C-terminus, arginine192-->histidine (R192H) by cardiac specific expression of the mutated protein (cTnI(193His) in mouse sequence) in transgenic mice. Histidine 67-76 troponin I3, cardiac type Homo sapiens 33-37 17027633-2 2006 We modeled one mutation in human cTnI C-terminus, arginine192-->histidine (R192H) by cardiac specific expression of the mutated protein (cTnI(193His) in mouse sequence) in transgenic mice. Histidine 67-76 troponin I3, cardiac type Homo sapiens 140-144 17081490-9 2006 While the successful incorporation of the His-tag into our constructs was confirmed by Epo binding to Ni(2+)- nitrilotriacetic acid resin and by microcapillary reverse-phase high-performance liquid chromatography nano-electrospray tandem mass spectrometery amino acid sequencing, the levels of immunodetection of His-tagged protein varied markedly depending on the particular anti-His-tag antibody used. Histidine 42-45 erythropoietin Cricetulus griseus 87-90 17040910-4 2006 Four conserved residues in the C-terminal loop of DPP8 (Phe(822), Val(833), Tyr(844), and His(859)), corresponding to those located at the dimer interface of DPP-IV, were individually mutated to Ala. Histidine 90-93 dipeptidyl peptidase 8 Homo sapiens 50-54 17035525-11 2006 In HEK-293 cells, coexpressed hemagglutinin-tagged KCC2 assembled with histidine-tagged KCC2, demonstrating formation of homomers. Histidine 71-80 solute carrier family 12 member 5 Homo sapiens 51-55 17035525-11 2006 In HEK-293 cells, coexpressed hemagglutinin-tagged KCC2 assembled with histidine-tagged KCC2, demonstrating formation of homomers. Histidine 71-80 solute carrier family 12 member 5 Homo sapiens 88-92 16487754-1 2006 Insulinoma associated-1 (INSM1, formerly IA-1) is a Cys(2)-His(2) zinc finger transcription factor sharing conserved regions with Caenorhabditis elegans EGL-46 and Drosophila Nerfin-1. Histidine 59-62 insulinoma-associated 1b Danio rerio 25-30 16967187-8 2006 All these findings suggested that the fused expressed His-DR inhibited the activity of natural DDR2, and relevant MMP-1 and MMP-2 expression in synoviocytes and NIH3T3 cells provoked by collagen II. Histidine 54-57 matrix metallopeptidase 2 Mus musculus 124-129 16934294-0 2006 Histidine triad-like motif of the rotavirus NSP2 octamer mediates both RTPase and NTPase activities. Histidine 0-9 inosine triphosphatase Homo sapiens 82-88 16807956-3 2006 l-His was a potent activator of isozymes I, VA, VII, and XIV, and a weaker activator of hCA II and IV. Histidine 0-5 carbonic anhydrase 2 Homo sapiens 88-101 16807956-5 2006 The structures as determined by X-ray crystallography of the hCA II-l-His/d-His adducts showed the activators to be anchored at the entrance of the active site, contributing to extended networks of hydrogen bonds with amino acid residues/water molecules present in the cavity, explaining their different potency and interaction patterns with various isozymes. Histidine 70-73 carbonic anhydrase 2 Homo sapiens 61-67 16807956-5 2006 The structures as determined by X-ray crystallography of the hCA II-l-His/d-His adducts showed the activators to be anchored at the entrance of the active site, contributing to extended networks of hydrogen bonds with amino acid residues/water molecules present in the cavity, explaining their different potency and interaction patterns with various isozymes. Histidine 76-79 carbonic anhydrase 2 Homo sapiens 61-67 16822869-9 2006 These data suggest that highly conserved arginine and histidine residues may compensate for variation elsewhere in the a1 and a2 plasminogen binding repeats, and may explain the maintenance of high affinity plasminogen binding by naturally occurring variants of PAM. Histidine 54-63 peptidylglycine alpha-amidating monooxygenase Homo sapiens 262-265 17087066-1 2006 Recombinant antigen ORF2 from porcine circovirus type 2 (PCV-2) was produced, by using the baculovirus expression system, with histidine tags to allow purification by metal-chelate affinity chromatography. Histidine 127-136 capsid protein Porcine circovirus 2 20-24 16702225-4 2006 These studies reveal that binding of a pY peptide to the N-SH2 domain of SHP-2 is greatly enhanced by a large hydrophobic residue (Trp, Tyr, Met, or Phe) at the pY+4 and/or pY+5 positions, whereas binding to SHP-1 N-SH2 domain is enhanced by either hydrophobic or positively charged residues (Arg, Lys, or His) at these positions. Histidine 306-309 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 73-78 16714405-3 2006 A purified N-terminally hexahistidinyl-tagged AtPCS1 truncate containing only the first 221 N-terminal amino acid residues of the enzyme (HIS-AtPCS1_221tr) is competent in the synthesis of PCs from GSH in media containing Cd2+ or the synthesis of S-methyl-PCs from S-methylglutathione in media devoid of heavy metal ions. Histidine 138-141 Eukaryotic aspartyl protease family protein Arabidopsis thaliana 46-52 16714405-3 2006 A purified N-terminally hexahistidinyl-tagged AtPCS1 truncate containing only the first 221 N-terminal amino acid residues of the enzyme (HIS-AtPCS1_221tr) is competent in the synthesis of PCs from GSH in media containing Cd2+ or the synthesis of S-methyl-PCs from S-methylglutathione in media devoid of heavy metal ions. Histidine 138-141 Eukaryotic aspartyl protease family protein Arabidopsis thaliana 142-148 16685272-6 2006 Immunocytochemistry of HuH7 cells transiently transfected with V5-His-tagged dermcidin confirmed targeting to the secretory pathway. Histidine 66-69 dermcidin Homo sapiens 77-86 16641296-6 2006 The native structure of the protease reveals strong hydrogen bond interactions between His 30 and Glu 54, in the favorable syn configuration, indicating a role of Glu 54 during proteolysis. Histidine 87-90 synemin Homo sapiens 123-126 16762846-4 2006 The phosphorylation of ATF2 was detected to assay the effect of His-TAT-p38 on endogeneious p38 activity after the cells were stimulated by sorbitol. Histidine 64-67 activating transcription factor 2 Homo sapiens 23-27 16289913-5 2006 The expression of all subunits increased with increase in infection time up to 72 h. We have also over expressed three mutant forms of eIF2alpha viz, S51A, S51D, and S48A in which the serine at 51 or 48 position is replaced by an alanine or aspartic acid with 6x histidine tag at the N-terminus. Histidine 263-272 eukaryotic translation initiation factor 2A Homo sapiens 135-144 16696901-3 2006 In present study, the extracellular domain of human PD-1 with a carboxyl terminal His-tag (designated as sPD-1) was expressed as inclusion bodies in Escherichia coli. Histidine 82-85 homeobox D13 Homo sapiens 105-110 16407305-7 2006 The results indicate that the lactonase activity of PON1 and PON3 and the esterase activity of PON1 are mediated by the His(115)-His(134) dyad. Histidine 120-123 paraoxonase 3 Homo sapiens 61-65 16407305-7 2006 The results indicate that the lactonase activity of PON1 and PON3 and the esterase activity of PON1 are mediated by the His(115)-His(134) dyad. Histidine 129-132 paraoxonase 3 Homo sapiens 61-65 16510609-6 2006 In the CBCS, positive associations were observed between breast cancer and smoking dose for participants with XRCC1 codon 194 Arg/Arg (P(trend) = 0.046), 399 Arg/Arg (P(trend) = 0.012), and 280 His/His or His/Arg (P(trend) = 0.047) genotypes. Histidine 194-197 X-ray repair cross complementing 1 Homo sapiens 110-115 16510609-6 2006 In the CBCS, positive associations were observed between breast cancer and smoking dose for participants with XRCC1 codon 194 Arg/Arg (P(trend) = 0.046), 399 Arg/Arg (P(trend) = 0.012), and 280 His/His or His/Arg (P(trend) = 0.047) genotypes. Histidine 198-201 X-ray repair cross complementing 1 Homo sapiens 110-115 16510609-6 2006 In the CBCS, positive associations were observed between breast cancer and smoking dose for participants with XRCC1 codon 194 Arg/Arg (P(trend) = 0.046), 399 Arg/Arg (P(trend) = 0.012), and 280 His/His or His/Arg (P(trend) = 0.047) genotypes. Histidine 198-201 X-ray repair cross complementing 1 Homo sapiens 110-115 16442528-11 2006 Moreover, the NTHK1 functional kinase domain phosphorylated the HIS and ATP subdomains, and five putative phosphorylation sites were identified in these two subdomains. Histidine 64-67 histidine kinase1 Nicotiana tabacum 14-19 16828466-5 2006 Moving in vivo, we demonstrated that subcutaneously administered his(6)CTLA-4.FasL modulates the in vivo response of infused allogeneic splenocytes. Histidine 65-68 cytotoxic T-lymphocyte-associated protein 4 Mus musculus 71-77 16441489-4 2006 The HLA-DQB1*0627 alleles contain a nucleotide substitution at position 184 (T to C) resulting in an amino acid exchange from tyrosine to histidine. Histidine 138-147 major histocompatibility complex, class II, DQ beta 1 Homo sapiens 4-12 16388603-0 2006 Sir2 protein deacetylases: evidence for chemical intermediates and functions of a conserved histidine. Histidine 92-101 sirtuin 1 Homo sapiens 0-4 16388603-4 2006 In this study, Sir2-catalyzed reactions are shown to transfer an 18O label from the peptide acetyl group to the ribose 1"-position of OAADPr, providing direct evidence for the formation of a covalent alpha-1"-O-alkylamidate, whose existence is further supported by the observed methanolysis of the alpha-1"-O-alkylamidate intermediate to yield beta-1"-O-methyl-ADP-ribose in a Sir2 histidine-to-alanine mutant. Histidine 382-391 sirtuin 1 Homo sapiens 15-19 16388603-4 2006 In this study, Sir2-catalyzed reactions are shown to transfer an 18O label from the peptide acetyl group to the ribose 1"-position of OAADPr, providing direct evidence for the formation of a covalent alpha-1"-O-alkylamidate, whose existence is further supported by the observed methanolysis of the alpha-1"-O-alkylamidate intermediate to yield beta-1"-O-methyl-ADP-ribose in a Sir2 histidine-to-alanine mutant. Histidine 382-391 sirtuin 1 Homo sapiens 377-381 16651828-8 2006 The present study indicates that histidine-rich material rapidly associates with newly synthesized filaments of keratin. Histidine 33-42 keratin Gallus gallus 112-119 16651828-9 2006 This observation suggests that histidine-labeled material contributes to the formation of long keratin filaments with axial orientation that are utilized for the elongation of barb and barbule cells. Histidine 31-40 keratin Gallus gallus 95-102 16214338-1 2005 Activation of the carbonic anhydrase (CA, EC 4.2.1.1) isoforms hCA I, II, and IV with l-histidine and some of its derivatives has been investigated by kinetic and X-ray crystallographic methods. Histidine 86-97 carbonic anhydrase 1 Homo sapiens 63-68 16214338-4 2005 The X-ray crystallographic structure of the hCA II-l-His adduct showed the activator to be anchored at the entrance of the active site cavity, participating in an extended network of hydrogen bonds with the amino acid residues His64, Asn67, and Gln92 and, with three water molecules connecting it to the zinc-bound water. Histidine 53-56 carbonic anhydrase 2 Homo sapiens 44-50 16314460-6 2005 Thus, in U4 atac snRNA we identified His 270 in the spliceosomal U4/U6 snRNP-specific protein 61 K (hPrp31p) cross-linked to U 44; in the U1 snRNP we show that Leu175 of the U1 snRNP-specific 70K protein is cross-linked to U 30 of U1 snRNA. Histidine 37-40 pre-mRNA processing factor 31 Homo sapiens 100-107 16274242-1 2005 The alkaline transition kinetics of a Lys 73-->His (H73) variant of iso-1-cytochrome c are triggered by three ionizable groups [Martinez, R. E., and Bowler, B. E. (2004) J. Histidine 50-53 eukaryotic translation initiation factor 1 Homo sapiens 71-76 16142924-1 2005 The rat organic cation transporter rOCT1 with six histidine residues added to the C-terminus was expressed in Sf9 insect cells, and expression of organic cation transport was demonstrated. Histidine 50-59 solute carrier family 22 member 1 Rattus norvegicus 35-40 16014379-2 2005 In this study, Hint1/PKCI, a member of the evolutionary conserved family of histidine triad proteins, was characterised as a new interaction partner of Pontin and Reptin. Histidine 76-85 protein kinase C iota Homo sapiens 21-25 15761875-3 2005 Besides this side reaction, the failure of N(alpha)-Boc deprotection from the His(pi-Bom) residue occurs during TFA treatment for the standard solid-phase peptide synthesis (SPPS) even in the case of a non "difficult sequence". Histidine 78-81 BOC cell adhesion associated, oncogene regulated Homo sapiens 52-55 15761875-5 2005 Reviewing the removability of the Boc group on amino acid derivatives showed that the group on the His(pi-Bom) residue was much more resistant under the deprotecting conditions than expected. Histidine 99-102 BOC cell adhesion associated, oncogene regulated Homo sapiens 34-37 15840587-4 2005 Biochemical analysis showed that bacterial His-tagged p12 could be converted into a dimeric p25 in a reducing agent-dependent manner, and mutating the only cysteine residue of p12 (Cys(105) --> Ala(105)) abolished the dimerization. Histidine 43-46 tubulin polymerization promoting protein Homo sapiens 92-95 15621250-9 2005 By N-terminal analysis using aminopeptidase and RP-HPLC, it was confirmed that the lowered bioactivity of VAPG stemmed from the polymer conjugation to N-terminal histidine moieties, which actively participate in binding to GLP-1 receptors, resulting in only 16% of N-terminal histidine remaining intact after the conjugation reaction. Histidine 162-171 glucagon Rattus norvegicus 223-228 15896208-3 2005 The new allele differs from Cw*020202 by one nucleotide substitution at nucleotide 61 (G-->A) of exon 2, which translates to a difference of one amino acid at residue 21 (His-->Arg) of the HLA-C heavy chain. Histidine 174-177 major histocompatibility complex, class I, C Homo sapiens 195-200 15900495-6 2005 Most of the protein sequence features involved in binding ATP are conserved, with two exceptions: chicken TAP1 has a glycine in the switch region where other TAPs have glutamine or histidine, and both chicken TAP genes have serines in the C motif where mammalian TAP2 has an alanine. Histidine 181-190 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) Gallus gallus 106-110 15900495-6 2005 Most of the protein sequence features involved in binding ATP are conserved, with two exceptions: chicken TAP1 has a glycine in the switch region where other TAPs have glutamine or histidine, and both chicken TAP genes have serines in the C motif where mammalian TAP2 has an alanine. Histidine 181-190 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) Gallus gallus 106-109 16511042-3 2005 Although ZmHP1 with an N-terminal His tag could be crystallized using sodium chloride as a precipitant, the crystals diffracted poorly to only 3.2 A resolution. Histidine 34-37 histidine-containing phosphotransfer protein Zea mays 9-14 15900706-8 2005 A recombinant, C-terminally His-tagged synaptobrevin fragment bound to nickel beads specifically bound synaptophysin, syntaxin and SNAP25 from vesicular detergent extracts. Histidine 28-31 synaptophysin Homo sapiens 103-116 15819897-3 2005 Moreover, flash photolysis experiments at high temperatures reveal that Ngb remains functional at 90 degrees C. Human Ngb may have a disulfide bond in the CD loop region; reduction of the disulfide bond increases the affinity of the iron atom for the distal (E7) histidine, and leads to a 3 degrees C increase in the T(m) for ferrous Ngb. Histidine 263-272 neuroglobin Homo sapiens 72-75 15819897-3 2005 Moreover, flash photolysis experiments at high temperatures reveal that Ngb remains functional at 90 degrees C. Human Ngb may have a disulfide bond in the CD loop region; reduction of the disulfide bond increases the affinity of the iron atom for the distal (E7) histidine, and leads to a 3 degrees C increase in the T(m) for ferrous Ngb. Histidine 263-272 neuroglobin Homo sapiens 118-121 15819897-3 2005 Moreover, flash photolysis experiments at high temperatures reveal that Ngb remains functional at 90 degrees C. Human Ngb may have a disulfide bond in the CD loop region; reduction of the disulfide bond increases the affinity of the iron atom for the distal (E7) histidine, and leads to a 3 degrees C increase in the T(m) for ferrous Ngb. Histidine 263-272 neuroglobin Homo sapiens 118-121 15819897-7 2005 Only globins with a high affinity of the distal histidine show the very high thermal stability, indicating that stable hexa-coordination is necessary for the enhanced thermal stability; the CD loop which contains the cysteines appears as a critical region in the neuroglobin thermal stability, because it may influence the affinity of the distal histidine. Histidine 48-57 neuroglobin Homo sapiens 263-274 15572352-2 2005 ATP-dependent uptake of histidine and lysine by isolated vacuolar membrane vesicles was impaired in YMR088c, a vacuolar basic amino acid transporter 1 (VBA1)-deleted strain, whereas uptake of tyrosine or calcium was little affected. Histidine 24-33 Vba1p Saccharomyces cerevisiae S288C 152-156 15572352-3 2005 This defect in histidine and lysine uptake was complemented fully by introducing the VBA1 gene and partially by a gene encoding Vba1p fused with green fluorescent protein, which was determined to localize exclusively to the vacuolar membrane. Histidine 15-24 Vba1p Saccharomyces cerevisiae S288C 85-89 15572352-3 2005 This defect in histidine and lysine uptake was complemented fully by introducing the VBA1 gene and partially by a gene encoding Vba1p fused with green fluorescent protein, which was determined to localize exclusively to the vacuolar membrane. Histidine 15-24 Vba1p Saccharomyces cerevisiae S288C 128-133 15804708-2 2005 This antibody is directed against the histidyl-tRNA synthetase which catalyses the binding of the histidine to its cognate tRNA during protein synthesis. Histidine 98-107 histidyl-tRNA synthetase 1 Homo sapiens 38-62 15667203-0 2005 Structural and kinetic characterization of active-site histidine as a proton shuttle in catalysis by human carbonic anhydrase II. Histidine 55-64 carbonic anhydrase 2 Homo sapiens 107-128 15667203-1 2005 In the catalysis of the hydration of carbon dioxide and dehydration of bicarbonate by human carbonic anhydrase II (HCA II), a histidine residue (His64) shuttles protons between the zinc-bound solvent molecule and the bulk solution. Histidine 126-135 carbonic anhydrase 2 Homo sapiens 92-113 15661533-4 2005 OVCA1 appears to be the homolog of yeast DPH2, which participates in the first biosynthetic step of diphthamide, by modification of histidine on translation elongation factor 2 (EF-2). Histidine 132-141 diphthamide biosynthesis 1 Mus musculus 0-5 15668381-4 2005 The structures confirm that SABP2 is a member of the alpha/beta hydrolase superfamily of enzymes, with Ser-81, His-238, and Asp-210 as the catalytic triad. Histidine 111-114 salicylic acid-binding protein 2 Nicotiana tabacum 28-33 15358768-3 2004 It has been previously shown that a subfamily 1 Arabidopsis thaliana ethylene receptor, ETR1, autophosphorylates in vitro on a conserved histidine residue (1). Histidine 137-146 Signal transduction histidine kinase, hybrid-type, ethylene sensor Arabidopsis thaliana 88-92 15358768-8 2004 ERS1, the only other subfamily 1 receptor, is able to phosphorylate on both histidine and serine residues in the presence of Mn2+. Histidine 76-85 ethylene response sensor 1 Arabidopsis thaliana 0-4 15358768-9 2004 However, histidine autophosphorylation is lost when ERS1 is assayed in the presence of both Mg2+ and Mn2+, suggesting that this activity may not occur in vivo. Histidine 9-18 ethylene response sensor 1 Arabidopsis thaliana 52-56 15488767-1 2004 Both the ferrous and ferric forms of wild-type neuroglobin are found to be hexacoordinated with axial ligation of the F8-His and E7-His. Histidine 121-124 neuroglobin Homo sapiens 47-58 15488767-1 2004 Both the ferrous and ferric forms of wild-type neuroglobin are found to be hexacoordinated with axial ligation of the F8-His and E7-His. Histidine 132-135 neuroglobin Homo sapiens 47-58 15804833-4 2004 As with some plant and bacterial globins, neuroglobin and cytoglobin hemes are hexacoordinate in the absence of external ligands, in that the heme iron atom coordinates both a proximal and a distal His residue. Histidine 198-201 neuroglobin Homo sapiens 42-53 15476823-2 2004 The site of interaction of the tumor suppressor p53 and the oncoprotein E1A with CBP/p300 has been identified with the third cysteine-histidine-rich (CH3) domain, which incorporates two zinc-binding motifs, ZZ and TAZ2. Histidine 134-143 CREB binding protein Mus musculus 81-84 15476823-2 2004 The site of interaction of the tumor suppressor p53 and the oncoprotein E1A with CBP/p300 has been identified with the third cysteine-histidine-rich (CH3) domain, which incorporates two zinc-binding motifs, ZZ and TAZ2. Histidine 134-143 E1A binding protein p300 Mus musculus 85-89 11545602-12 2001 If the protonation state of a histidine, aspartate or glutamate protein side-chain is known, specific CSD-based maps for that protonation state are preferred over PDB-based maps which represent an ensemble of protonation states. Histidine 30-39 cysteine sulfinic acid decarboxylase Homo sapiens 102-105 11488596-0 2001 Disruption of histidine catabolism in NEUT2 mice. Histidine 14-23 aldehyde dehydrogenase 1 family, member L1 Mus musculus 38-43 11393758-2 2001 It describes the simple mixing of a 99mTc(I)-carbonyl compound [99mTc(OH2)3(CO)3]+ with a histidine-tagged somatostatin-dextran (SMS-Dx-His) conjugate. Histidine 90-99 somatostatin Homo sapiens 107-119 11488913-5 2001 Bacterially expressed chicken IL-6 (ChIL-6) carrying a histidine tag in place of the signal peptide was biologically active: it induced proliferation of the IL-6-dependent murine hybridoma cell line 7TD1. Histidine 55-64 interleukin 6 Gallus gallus 30-34 11488913-5 2001 Bacterially expressed chicken IL-6 (ChIL-6) carrying a histidine tag in place of the signal peptide was biologically active: it induced proliferation of the IL-6-dependent murine hybridoma cell line 7TD1. Histidine 55-64 interleukin 6 Gallus gallus 36-42 11488913-5 2001 Bacterially expressed chicken IL-6 (ChIL-6) carrying a histidine tag in place of the signal peptide was biologically active: it induced proliferation of the IL-6-dependent murine hybridoma cell line 7TD1. Histidine 55-64 interleukin 6 Gallus gallus 38-42 11489458-0 2001 Slowing of ERG current deactivation in NG108-15 cells by the histidine-specific reagent diethylpyrocarbonate. Histidine 61-70 ETS transcription factor Mus musculus 11-14 11489458-1 2001 The aim of this study was to explore and characterize the effect of the histidine-specific reagent diethylpyrocarbonate (DEPC) on the ERG (ether-a-go-go related gene) channels of whole-cell voltage-clamped NG108-15 neuroblastoma x glioma hybrid cells. Histidine 72-81 ETS transcription factor Mus musculus 134-137 11489458-1 2001 The aim of this study was to explore and characterize the effect of the histidine-specific reagent diethylpyrocarbonate (DEPC) on the ERG (ether-a-go-go related gene) channels of whole-cell voltage-clamped NG108-15 neuroblastoma x glioma hybrid cells. Histidine 72-81 ETS transcription factor Mus musculus 139-165 11371582-5 2001 Also, human growth hormone receptor (GHR) displays species specificity; i.e., it can interact only with human (or rhesus monkey) GH, not with nonprimate GHS: The species specificity of human GHR is largely due to the Leu-->Arg change at position 43, and it has been hypothesized that this change must have been preceded by the His-->Asp change at position 171 of GH. Histidine 330-333 growth hormone receptor Homo sapiens 12-35 11371582-5 2001 Also, human growth hormone receptor (GHR) displays species specificity; i.e., it can interact only with human (or rhesus monkey) GH, not with nonprimate GHS: The species specificity of human GHR is largely due to the Leu-->Arg change at position 43, and it has been hypothesized that this change must have been preceded by the His-->Asp change at position 171 of GH. Histidine 330-333 growth hormone receptor Homo sapiens 37-40 11371582-5 2001 Also, human growth hormone receptor (GHR) displays species specificity; i.e., it can interact only with human (or rhesus monkey) GH, not with nonprimate GHS: The species specificity of human GHR is largely due to the Leu-->Arg change at position 43, and it has been hypothesized that this change must have been preceded by the His-->Asp change at position 171 of GH. Histidine 330-333 growth hormone receptor Homo sapiens 191-194 11278524-3 2001 We genetically modified the C terminus of hIL-18BP by appending a 15-amino acid biotinylation recognition site and a six-histidine tag and then performed site-directed mutagenesis to determine the functional epitopes that mediate efficient binding to IL-18. Histidine 121-130 interleukin 18 Homo sapiens 43-48 11336635-9 2001 Recombinant rPHT2 protein reconstituted into liposomes showed proton-dependent transport activity with histidine and histidyl-leucine. Histidine 103-112 solute carrier family 15 member 3 Rattus norvegicus 12-17 11320329-0 2001 Post-translational modification of the N-terminal His tag interferes with the crystallization of the wild-type and mutant SH3 domains from chicken src tyrosine kinase. Histidine 50-53 SRC proto-oncogene, non-receptor tyrosine kinase Gallus gallus 147-150 11289130-3 2001 Resistance to this peptide and another toxic peptide derivative, which is based on a Thr-His-Thr-Nle-Glu-Gly backbone conjugated to butyl and benzyl groups (4A6), could be reversed by MRP1 inhibitors. Histidine 89-92 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Mus musculus 184-188 11255023-1 2001 Queuosine (Q) is a 7-deazaguanosine found in the first position of the anticodon of tRNAs that recognize NAU and NAC codons (Tyr, Asn, Asp and His). Histidine 143-146 X-linked Kx blood group Homo sapiens 113-116 11239577-4 2001 The first three-dimensional structure of the unique NAT family shows the active-site cysteine to be aligned with conserved histidine and aspartate residues to form a catalytic triad, thus providing an activation mechanism for transfer of the acetyl group from acetyl CoA to cysteine. Histidine 123-132 bromodomain containing 2 Homo sapiens 52-55 11031263-7 2001 These surprising results are in marked contrast to the effects ascribed to the corresponding lower axial histidine ligands in the cobalamin-dependent enzymes glutamate mutase and methionine synthase. Histidine 105-114 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 179-198 11115608-4 2001 NS1 bound to the two related cysteine-histidine-rich regions of CBP, referred to as C/H1 and C/H3, the former of which has an antagonistic function to CBP upon the NS1-transactivation. Histidine 38-47 influenza virus NS1A binding protein Homo sapiens 0-3 11115608-4 2001 NS1 bound to the two related cysteine-histidine-rich regions of CBP, referred to as C/H1 and C/H3, the former of which has an antagonistic function to CBP upon the NS1-transactivation. Histidine 38-47 influenza virus NS1A binding protein Homo sapiens 164-167 11104674-3 2000 This tyrosine residue is conserved in most AKR family members including AKR1C1-1C3, but is replaced with histidine in AKR1C4 and phenylalanine in some AKR members. Histidine 105-114 aldo-keto reductase family 1 member C4 Homo sapiens 118-124 11104674-9 2000 These results indicate the importance of this histidine residue in creating the cavity of the substrate-binding site of AKR1C4 through the orientation of the nicotinamide ring of the coenzyme, as well as its involvement in the conformational change by binding non-essential activators. Histidine 46-55 aldo-keto reductase family 1 member C4 Homo sapiens 120-126 11185565-6 2000 In the case of CPR, the inhibitory effect is probably due to Cd2+ binding to the histidine residue of the apoenzyme, which, at physiological pH, acts as a nucleophilic group. Histidine 81-90 cytochrome p450 oxidoreductase Rattus norvegicus 15-18 11041873-5 2000 The mMCP-6 fusion protein contained an N-terminal 6 x His tag followed by an enterokinase (EK) site replacing the native activation peptide (6xHis-EK-mMCP-6). Histidine 54-57 tryptase beta 2 Mus musculus 4-10 10978164-4 2000 The results suggest that, in addition to stabilizing the reactive intermediate compound I, the distal arginine plays an important role as a gatekeeper in the active site of CCP, controlling the access to the ferryl oxygen and the distal histidine. Histidine 237-246 cytochrome-c peroxidase Saccharomyces cerevisiae S288C 173-176 10969139-1 2000 alpha-amidation of a peptide (which takes place from a glycine-extended precursor) is required to produce biologically active amidated hormones, such as gastrin-releasing peptide (GRP)/Pyr-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH(2) (bombesin). Histidine 229-232 gastrin releasing peptide Rattus norvegicus 153-178 10969139-1 2000 alpha-amidation of a peptide (which takes place from a glycine-extended precursor) is required to produce biologically active amidated hormones, such as gastrin-releasing peptide (GRP)/Pyr-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH(2) (bombesin). Histidine 229-232 gastrin releasing peptide Rattus norvegicus 180-183 10915606-3 2000 Our study provides experimental evidence that histidine at position 1658 and aspartic acid at position 1686 constitute together with the previously identified serine at position 1752 (S1752) the catalytic triad of the pestiviral NS3 serine protease. Histidine 46-55 KRAS proto-oncogene, GTPase Homo sapiens 229-232 10787436-8 2000 These data suggest that residues T123 and F382, located N-terminal of helices alpha 3-4 and alpha His, contribute specifically to the interaction of LCAT with HDL and possibly with its co-factor apoA-I. Histidine 98-101 lecithin-cholesterol acyltransferase Homo sapiens 149-153 10773212-4 2000 The radioactivity of the aqueduct was also higher in the 65Zn-His group, indicating that CSF clearance of the 65Zn-His group may be lower than that of the 65ZnCl(2) group. Histidine 62-65 colony stimulating factor 2 Rattus norvegicus 89-92 10773212-5 2000 These results suggest an enhancement by histidine on zinc uptake in the brain parenchyma via the CSF. Histidine 40-49 colony stimulating factor 2 Rattus norvegicus 97-100 10788626-3 2000 In non-primate GHs, His(170) replaces the homologous Asp(171), producing a repulsive interaction with Arg(43) of the primate receptor which was believed to reduce the attraction of non-primate GH for the human GH receptor, thus providing species specificity. Histidine 20-23 growth hormone receptor Homo sapiens 210-221 10766853-9 2000 The caspase inhibitors carbobenzoxy-Leu-Glu-His-Asp-CH(2)F and carbobenzoxy-Asp-Glu-Val-Asp-CH(2)F, but not carbobenzoxy-Ile-Glu-Thr-Asp-CH(2)F, differentially blocked post-mitochondrial events. Histidine 44-47 caspase 8 Rattus norvegicus 4-11 10692590-0 2000 Identification of active site serine and histidine residues in Escherichia coli outer membrane protease OmpT. Histidine 41-50 outer membrane protease Escherichia coli 104-108 10692590-7 2000 We propose that OmpT is a novel serine protease with Ser(99) as the active site nucleophile and His(212) as general base. Histidine 96-99 outer membrane protease Escherichia coli 16-20 10648402-2 2000 The vWf-binding site on GP Ib-IX-V is within the N-terminal 282 residues of GP Ibalpha, which consist of an N-terminal flanking sequence (His-1-Ile-35), 7 leucine-rich repeats (Leu-36-Ala-200), a C-terminal flank (Phe-201-Gly-268), and a sulfated tyrosine sequence (Asp-269-Glu-282). Histidine 138-141 glycoprotein Ib platelet subunit alpha Homo sapiens 76-86 10692054-2 2000 We report the expression in Chinese hamster ovary (CHO) cells of a modified mouse CD59 cDNA that had been truncated at D-74, resulting in the loss of the glycosylphosphatidyl inositol (GPI) anchor, and containing six additional C-terminal histidines. Histidine 239-249 CD59a antigen Mus musculus 82-86 10627484-5 2000 Substitution of His for Arg at this site resulted in the blockage of Factor Xa cleavage, forming a dysfunctional molecule. Histidine 16-19 coagulation factor X Homo sapiens 69-78 10631324-2 2000 The N-half of the deduced amino acid sequence of 432 amino acids of CROP contains cysteine/histidine motifs and leucine zipper-like repeats. Histidine 91-100 LUC7 like 3 pre-mRNA splicing factor Homo sapiens 68-72 15693279-10 2000 In agreement with this possibility, the A beta peptide reduces less copper in the presence of exogenous histidine. Histidine 104-113 amyloid beta precursor protein Rattus norvegicus 40-46 10701841-6 2000 Therefore, both GST-SStp and His-S-SStp can be used as affinity-tagged substrates to study prokaryotic chaperone/transit peptide interactions as well as to provide a novel functional probe to study the dynamics of DnaK/DnaJ/GrpE interactions in vivo. Histidine 29-32 DnaJ heat shock protein family (Hsp40) member B6 Homo sapiens 219-223 10663563-9 2000 Mature pig IL-5 was expressed in Escherichia coli with a His-tag for purification. Histidine 57-60 interleukin 5 Sus scrofa 11-15 11030087-8 2000 Best activity was shown against hCA I and bCA IV, for which some of the new compounds (such as the Lys, Arg, His or the dipeptide derivatives) showed affinities in the 2-12 nm range (h = human; b = bovine isozymes). Histidine 109-112 carbonic anhydrase 1 Homo sapiens 32-37 10715790-2 1999 METHODS: E2/NS1 gene derived from HCV was inserted into expression vector containing six His tag. Histidine 89-92 influenza virus NS1A binding protein Homo sapiens 12-15 10549857-1 1999 The variable regions of heavy- and light-chains of mouse monoclonal antibody 196-14 toward ovarian cancer-associated antigen CA125 were linked with a peptide linker (GSTSGSGKSSEGKG) and a histidine tag was attached at the carboxyl terminal. Histidine 188-197 mucin 16, cell surface associated Homo sapiens 125-130 10504417-6 1999 Both the unmodified and the partially purified His-tagged p94 bound calcium with high affinity, and their autolytic activity required Ca2+. Histidine 47-50 calpain 3 Homo sapiens 58-61 10582332-4 1999 Namely, a [2Fe-2S] cluster is a prosthetic group in mammalian ferrochelatase, a conserved and essential histidine residue appears to be involved in the binding of the metal substrate and a conserved glutamate residue has been proposed to have a catalytic role. Histidine 104-113 ferrochelatase Homo sapiens 62-76 10582345-1 1999 Basic Kruppel-like Factor (BKLF) is a recently recognized member of a small group of transcription factors that bind CACCC motifs in DNA, by means of three highly conserved C-terminal Kruppel-like (typically Cys-X2-4-Cys-X12-His-X3-4-His) zinc fingers. Histidine 225-228 Kruppel-like factor 3 (basic) Mus musculus 0-25 10582345-1 1999 Basic Kruppel-like Factor (BKLF) is a recently recognized member of a small group of transcription factors that bind CACCC motifs in DNA, by means of three highly conserved C-terminal Kruppel-like (typically Cys-X2-4-Cys-X12-His-X3-4-His) zinc fingers. Histidine 225-228 Kruppel-like factor 3 (basic) Mus musculus 27-31 10537216-4 1999 These proteins also showed 40-60% identity to the delta9-desaturases (Ole1p) of other fungi and contained the three conserved histidine boxes, C-terminal cytochrome b5 fusion and transmembrane domains characteristic of endoplasmic reticulum membrane-bound delta9-desaturases. Histidine 126-135 stearoyl-CoA 9-desaturase Saccharomyces cerevisiae S288C 70-75 10556554-3 1999 A mutant of carbonic anhydrase II containing the replacement His-64-->Ala, which removes the prominent histidine proton shuttle (with pK(a) near 7), allows better observation of these basic groups. Histidine 61-64 carbonic anhydrase 2 Homo sapiens 12-33 10556554-3 1999 A mutant of carbonic anhydrase II containing the replacement His-64-->Ala, which removes the prominent histidine proton shuttle (with pK(a) near 7), allows better observation of these basic groups. Histidine 106-115 carbonic anhydrase 2 Homo sapiens 12-33 10467162-6 1999 A (His)(6)-tagged protein comprising residues 455-511 of PKN (designated His-Ialpha) inhibited the kinase activity of the catalytic fragment of PKN in a concentration-dependent manner in competition with substrate (K(i) = 0.6+/-0.2 microM). Histidine 3-6 protein kinase N1 Homo sapiens 57-60 10467162-6 1999 A (His)(6)-tagged protein comprising residues 455-511 of PKN (designated His-Ialpha) inhibited the kinase activity of the catalytic fragment of PKN in a concentration-dependent manner in competition with substrate (K(i) = 0.6+/-0.2 microM). Histidine 3-6 protein kinase N1 Homo sapiens 144-147 10428989-0 1999 Characterization of C-terminal histidine-tagged human recombinant lecithin:cholesterol acyltransferase. Histidine 31-40 lecithin-cholesterol acyltransferase Homo sapiens 66-102 10428989-8 1999 We conclude that carboxy-terminal histidine-tagged LCAT is a suitable replacement for both plasma LCAT and CHO-hLCAT. Histidine 34-43 lecithin-cholesterol acyltransferase Homo sapiens 51-55 10428989-8 1999 We conclude that carboxy-terminal histidine-tagged LCAT is a suitable replacement for both plasma LCAT and CHO-hLCAT. Histidine 34-43 lecithin-cholesterol acyltransferase Homo sapiens 98-102 10423244-11 1999 It is likely that the behaviors of Tyr residues are controlled by the ligation of beta heme through His-beta 92(F8)-->Val-beta 98(FG5)-->Asp-beta 99(G1 )-->Tyr-alpha 42(C7) or Tyr-beta 145(HC2). Histidine 100-103 proline rich protein BstNI subfamily 3 Homo sapiens 147-157 10413479-11 1999 These data suggest that the hydrophobic cluster in CAII is important for orienting the histidine residues to stabilize metals bound with a distorted tetrahedral geometry and to destabilize the trigonal bipyramidal geometry of bound copper. Histidine 87-96 carbonic anhydrase 2 Homo sapiens 51-55 10450831-4 1999 The second homologue (STC2) is 30-38% identical to the fish stanniocalcins, and is characterized by unique cysteine and histidine motifs that are not found in the other stanniocalcins. Histidine 120-129 stanniocalcin 2 Homo sapiens 22-26 10410979-3 1999 Employing this method, a recombinant C3a (rC3a) anaphylatoxin with a His-tag at its N-terminus could be shown to bind to C3a receptor (C3aR)-expressing RBL-2H3 transfectants with a half-maximal effective concentration (EC50) of about 3 nM which is well within the range of published affinity constants. Histidine 69-72 complement C3 Homo sapiens 37-40 10386625-3 1999 After purification by Ni2+ affinity chromatography, His-tagged Ras-binding domain of c-Raf-1 could be isolated in sufficient amounts for biochemical and biophysical investigations. Histidine 52-55 TNF receptor associated factor 3 Homo sapiens 85-92 10085111-12 1999 Histidine residues at positions 46 and 60 are responsible for heme ligation because the H46N- or H60N-substituted QPs3 fail to restore cytochrome b560 upon addition of hemin chloride. Histidine 0-9 cytochrome b Bos taurus 135-147 10051312-5 1999 Comparison of mouse PR3 genomic structure with that of its human counterpart indicates that: 1) the mPR3 gene spans 7 kb organized in 5 exons and 4 introns, 2) the codons of His-Asp-Ser of the catalytic site are conserved and spread out over different exons, similar to the human gene, and 3) the gene product encodes a pre-proform of the protein. Histidine 174-177 proteinase 3 Mus musculus 100-104 10209751-10 1999 Incubation of extracts from Escherichia coli overexpressing His-VirE1 with the extracts of E. coli overexpressing His-VirE2 increased the yield of His-VirE2 in the soluble fraction. Histidine 60-63 type IV secretion system chaperone VirE1 Agrobacterium tumefaciens 64-69 10209751-10 1999 Incubation of extracts from Escherichia coli overexpressing His-VirE1 with the extracts of E. coli overexpressing His-VirE2 increased the yield of His-VirE2 in the soluble fraction. Histidine 60-63 type IV secretion system single-stranded DNA binding protein VirE2 Agrobacterium tumefaciens 118-123 10209751-10 1999 Incubation of extracts from Escherichia coli overexpressing His-VirE1 with the extracts of E. coli overexpressing His-VirE2 increased the yield of His-VirE2 in the soluble fraction. Histidine 60-63 type IV secretion system single-stranded DNA binding protein VirE2 Agrobacterium tumefaciens 151-156 10209751-10 1999 Incubation of extracts from Escherichia coli overexpressing His-VirE1 with the extracts of E. coli overexpressing His-VirE2 increased the yield of His-VirE2 in the soluble fraction. Histidine 114-117 type IV secretion system chaperone VirE1 Agrobacterium tumefaciens 64-69 10209751-10 1999 Incubation of extracts from Escherichia coli overexpressing His-VirE1 with the extracts of E. coli overexpressing His-VirE2 increased the yield of His-VirE2 in the soluble fraction. Histidine 114-117 type IV secretion system single-stranded DNA binding protein VirE2 Agrobacterium tumefaciens 118-123 10209751-10 1999 Incubation of extracts from Escherichia coli overexpressing His-VirE1 with the extracts of E. coli overexpressing His-VirE2 increased the yield of His-VirE2 in the soluble fraction. Histidine 114-117 type IV secretion system single-stranded DNA binding protein VirE2 Agrobacterium tumefaciens 151-156 10209751-10 1999 Incubation of extracts from Escherichia coli overexpressing His-VirE1 with the extracts of E. coli overexpressing His-VirE2 increased the yield of His-VirE2 in the soluble fraction. Histidine 114-117 type IV secretion system chaperone VirE1 Agrobacterium tumefaciens 64-69 10209751-10 1999 Incubation of extracts from Escherichia coli overexpressing His-VirE1 with the extracts of E. coli overexpressing His-VirE2 increased the yield of His-VirE2 in the soluble fraction. Histidine 114-117 type IV secretion system single-stranded DNA binding protein VirE2 Agrobacterium tumefaciens 118-123 10209751-10 1999 Incubation of extracts from Escherichia coli overexpressing His-VirE1 with the extracts of E. coli overexpressing His-VirE2 increased the yield of His-VirE2 in the soluble fraction. Histidine 114-117 type IV secretion system single-stranded DNA binding protein VirE2 Agrobacterium tumefaciens 151-156 10209751-11 1999 In a similar purified protein solubility assay, His-VirE1 increased the amount of His-VirE2 partitioning into the soluble fraction. Histidine 48-51 type IV secretion system chaperone VirE1 Agrobacterium tumefaciens 52-57 10209751-11 1999 In a similar purified protein solubility assay, His-VirE1 increased the amount of His-VirE2 partitioning into the soluble fraction. Histidine 48-51 type IV secretion system single-stranded DNA binding protein VirE2 Agrobacterium tumefaciens 86-91 10209751-11 1999 In a similar purified protein solubility assay, His-VirE1 increased the amount of His-VirE2 partitioning into the soluble fraction. Histidine 82-85 type IV secretion system chaperone VirE1 Agrobacterium tumefaciens 52-57 10209751-11 1999 In a similar purified protein solubility assay, His-VirE1 increased the amount of His-VirE2 partitioning into the soluble fraction. Histidine 82-85 type IV secretion system single-stranded DNA binding protein VirE2 Agrobacterium tumefaciens 86-91 10022827-6 1999 Systematic mutagenesis revealed a titratable C-terminal histidine residue (H216) in Kir6.2 to be the structural determinant, and electrostatic interaction between this residue and polyamines was shown to be the molecular mechanism underlying pH-dependent rectification. Histidine 56-65 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 84-90 10193578-9 1999 The effect of the MPO/H2O2/NaNO2 system was prevented by MPO inhibitors (sodium azide, isoniazid, salicylhydroxamic acid) and also by L-cysteine, L-methionine, L-tryptophan, L-tyrosine, L-histidine and reduced glutathione. Histidine 186-197 myeloperoxidase Equus caballus 18-21 9922258-1 1999 The nitrogen assimilation control protein (NAC) from Klebsiella aerogenes or Escherichia coli (NACK or NACE, respectively) is a transcriptional regulator that is both necessary and sufficient to activate transcription of the histidine utilization (hut) operon and to repress transcription of the glutamate dehydrogenase (gdh) operon in K. aerogenes. Histidine 225-234 glutamate dehydrogenase Escherichia coli 296-319 9922258-1 1999 The nitrogen assimilation control protein (NAC) from Klebsiella aerogenes or Escherichia coli (NACK or NACE, respectively) is a transcriptional regulator that is both necessary and sufficient to activate transcription of the histidine utilization (hut) operon and to repress transcription of the glutamate dehydrogenase (gdh) operon in K. aerogenes. Histidine 225-234 glutamate dehydrogenase Escherichia coli 321-324 9895333-0 1999 Posttranslational deamidation of proteins: the case of hemoglobin J Sardegna [alpha50(CD8)His-->Asn-->Asp]. Histidine 90-93 CD8a molecule Homo sapiens 86-89 9895333-1 1999 Hemoglobin J Sardegna [alpha50(CD8)His-->Asn -->Asp] is a human Hb variant in which a posttranslational deamidation process takes place, transforming an Asn to an Asp residue. Histidine 35-38 CD8a molecule Homo sapiens 31-34 10234805-8 1999 An N-cadherin peptidomimic containing the His-Ala-Val sequence to abrogate homotypic N-cadherin interactions inhibited chondrogenesis in a concentration-dependent manner. Histidine 42-45 cadherin 2 Mus musculus 85-95 10780438-2 1999 As a result, peptides with Thr/Glu/His and Gln/Asp were obtained in binding of DNA core and AP2, respectively. Histidine 35-38 transcription factor AP-2 alpha Homo sapiens 92-95 10030688-5 1998 Three of these proteins (HI-1: 36 kDa/pI 4.5, HI-10: 40 kDa/pI 5.5 and HI-19: 62 kDa/pI 5.0) exhibit a "progression-like" pattern, being induced by estradiol in MCF-7 cells and constitutively present/upregulated in the MCF-7/LCC1 growing without estradiol. Histidine 25-27 C-C motif chemokine ligand 16 Homo sapiens 225-229 9822691-4 1998 hIIa-PLA2 contains 13 lysines, 2 histidines, and 10 arginines that fall into 10 clusters. Histidine 33-43 phospholipase A2 group IIA Homo sapiens 5-9 9812990-8 1998 However, the leucine- and histidine-induced alterations in global protein synthesis and eIF2B activity were maintained in the presence of the hormone. Histidine 26-35 eukaryotic translation initiation factor 2B subunit delta Homo sapiens 88-93 9812990-9 1998 Overall, the results suggest that both leucine and histidine regulate global protein synthesis through modulation of eIF2B activity. Histidine 51-60 eukaryotic translation initiation factor 2B subunit delta Homo sapiens 117-122 9831246-8 1998 Amino acid residues Phe-1264 and His-1265 of IR are in a region comparable to Tyr-1250 and Tyr-1251 within human IGF-IR. Histidine 33-36 insulin like growth factor 1 receptor Homo sapiens 113-119 9774399-0 1998 Mutation at histidine 338 of gp91(phox) depletes FAD and affects expression of cytochrome b558 of the human NADPH oxidase. Histidine 12-21 BRCA2 DNA repair associated Homo sapiens 49-52 9774399-0 1998 Mutation at histidine 338 of gp91(phox) depletes FAD and affects expression of cytochrome b558 of the human NADPH oxidase. Histidine 12-21 mitochondrially encoded cytochrome b Homo sapiens 79-91 9774399-9 1998 These results indicate that His-338 is a very critical residue for FAD incorporation into the NADPH oxidase system. Histidine 28-31 BRCA2 DNA repair associated Homo sapiens 67-70 9722655-3 1998 Monoclonal antibodies against the histidine-rich D5 domain in the light chain of 2-chain HK abolished the inhibitory effect of 2-chain HK on spreading of MG-63 osteosarcoma cells on vitronectin-coated tissue-culture plastic. Histidine 34-43 vitronectin Homo sapiens 182-193 9722655-10 1998 The histidine-rich D5 domain of light chain of HK was identified as one of the binding sites of vitronectin, suggesting that the masking of the RGD cell-binding site of immobilized vitronectin is the molecular mechanism of anti-cell-spreading effect of HKa. Histidine 4-13 vitronectin Homo sapiens 96-107 9722655-10 1998 The histidine-rich D5 domain of light chain of HK was identified as one of the binding sites of vitronectin, suggesting that the masking of the RGD cell-binding site of immobilized vitronectin is the molecular mechanism of anti-cell-spreading effect of HKa. Histidine 4-13 vitronectin Homo sapiens 181-192 9724720-3 1998 Prediction of the histidylation function of the new family of minimalist tRNA-like structures relates to the geometry of resected pseudoknots that allows proper presentation to histidyl-tRNA synthetase of analogues of the histidine identity determinants N-1 and N73 present in tRNAs. Histidine 222-231 histidyl-tRNA synthetase 1 Homo sapiens 177-201 9807817-5 1998 The interaction between AtFKBP12 and AtFIP37 in the 2-hybrid system, as assessed by histidine auxotrophy and beta-galactosidase activity, was disrupted by FK506, but not by cyclosporin A, a drug that binds to cyclophilin A. Histidine 84-93 FKBP12 interacting protein 37 Arabidopsis thaliana 37-44 9718294-12 1998 Interestingly, lecithin:cholesterol acyltransferase (LCAT) activation results correlate qualitatively with the lipid-binding affinity for all mutants but apo Delta(88-98)A-I(+his), suggesting that this mutant has an altered and possibly noncooperative lipid-bound structure as well as an altered lipid-free structure. Histidine 175-178 lecithin-cholesterol acyltransferase Homo sapiens 15-51 9718294-12 1998 Interestingly, lecithin:cholesterol acyltransferase (LCAT) activation results correlate qualitatively with the lipid-binding affinity for all mutants but apo Delta(88-98)A-I(+his), suggesting that this mutant has an altered and possibly noncooperative lipid-bound structure as well as an altered lipid-free structure. Histidine 175-178 lecithin-cholesterol acyltransferase Homo sapiens 53-57 9688537-1 1998 Mutating the histidine at position 55 present at the subunit interface of the tetrameric E. coli single stranded DNA binding (SSB) protein to tyrosine or lysine leads to cells which are UV- and temperature-sensitive. Histidine 13-22 single-stranded DNA-binding protein Escherichia coli 126-129 9633600-3 1998 The amino acid residues participating in the two transitions were ascribed to His 48 and the N-terminal alpha-amino group for the active enzyme and to His 48 and Arg -1 for the proenzyme. Histidine 78-81 arginase 1 Bos taurus 162-168 9633600-3 1998 The amino acid residues participating in the two transitions were ascribed to His 48 and the N-terminal alpha-amino group for the active enzyme and to His 48 and Arg -1 for the proenzyme. Histidine 151-154 arginase 1 Bos taurus 162-168 9647635-4 1998 Each gene encodes a complete ORF with no less than 86% amino acid sequence identity to human RNase k6 with the eight cysteines and catalytic histidines (H15 and H123) and lysine (K38) typically observed among members of the RNase A superfamily. Histidine 141-151 ribonuclease A family member k6 Homo sapiens 93-101 9622597-4 1998 The protein was purified with its SAT activity, which was inhibited by cysteine, using the high affinity of the histidine tag in an Ni-NTA column. Histidine 112-121 streptothricin acetyltransferase Escherichia coli 34-37 9541544-0 1998 Modeling based on the structure of vicilins predicts a histidine cluster in the active site of oxalate oxidase. Histidine 55-64 germin-like protein 8-4 Triticum aestivum 95-110 9488672-3 1998 Unlike other proteins that interact with heparin via lysine or arginine residues, HPRG relies exclusively on histidine residues for this interaction. Histidine 109-118 histidine rich glycoprotein Homo sapiens 82-86 9488672-11 1998 This provides a mechanism to regulate the function of HPRG (the local pH) and rationalizes the role of its unique, conserved histidine-proline-rich domain. Histidine 125-134 histidine rich glycoprotein Homo sapiens 54-58 9482873-4 1998 Comparison of the GliPR model with the P14a structure lead to the identification of a common partially solvent-exposed spatial cluster of four amino acid residues, His-69, Glu-88, Glu-110, and His-127 in the GliPR numeration. Histidine 164-167 GLI pathogenesis related 1 Homo sapiens 18-23 9482873-4 1998 Comparison of the GliPR model with the P14a structure lead to the identification of a common partially solvent-exposed spatial cluster of four amino acid residues, His-69, Glu-88, Glu-110, and His-127 in the GliPR numeration. Histidine 164-167 GLI pathogenesis related 1 Homo sapiens 208-213 9482873-4 1998 Comparison of the GliPR model with the P14a structure lead to the identification of a common partially solvent-exposed spatial cluster of four amino acid residues, His-69, Glu-88, Glu-110, and His-127 in the GliPR numeration. Histidine 193-196 GLI pathogenesis related 1 Homo sapiens 18-23 9482873-4 1998 Comparison of the GliPR model with the P14a structure lead to the identification of a common partially solvent-exposed spatial cluster of four amino acid residues, His-69, Glu-88, Glu-110, and His-127 in the GliPR numeration. Histidine 193-196 GLI pathogenesis related 1 Homo sapiens 208-213 9502416-8 1998 Amino-terminal sequence analysis of the protein revealed a Gly-Pro-Ala-Lys-Ser-Pro-Tyr-Gln-Leu-Val-Leu-Gln-His-Ser-Arg sequence indistinguishable from an amino-terminal protein sequence deduced from a cDNA clone designated beta ig-h3, and it as well as the abnormal accumulations in GCD cross-reacted with beta ig-h3 antiserum. Histidine 107-110 transforming growth factor beta induced Homo sapiens 223-233 9502416-8 1998 Amino-terminal sequence analysis of the protein revealed a Gly-Pro-Ala-Lys-Ser-Pro-Tyr-Gln-Leu-Val-Leu-Gln-His-Ser-Arg sequence indistinguishable from an amino-terminal protein sequence deduced from a cDNA clone designated beta ig-h3, and it as well as the abnormal accumulations in GCD cross-reacted with beta ig-h3 antiserum. Histidine 107-110 transforming growth factor beta induced Homo sapiens 306-316 9525272-0 1998 Induction and localization of cytochrome P450 1B1 (CYP1B1) protein in the livers of TCDD-treated rats: detection using polyclonal antibodies raised to histidine-tagged fusion proteins produced and purified from bacteria. Histidine 151-160 cytochrome P450, family 1, subfamily b, polypeptide 1 Rattus norvegicus 30-49 9525272-0 1998 Induction and localization of cytochrome P450 1B1 (CYP1B1) protein in the livers of TCDD-treated rats: detection using polyclonal antibodies raised to histidine-tagged fusion proteins produced and purified from bacteria. Histidine 151-160 cytochrome P450, family 1, subfamily b, polypeptide 1 Rattus norvegicus 51-57 9480810-2 1998 It is generally accepted that the catalytic mechanism of LCAT is similar to that of serine proteases and lipases involving a Ser, a His, and an acidic amino acid residue. Histidine 132-135 lecithin-cholesterol acyltransferase Homo sapiens 57-61 9480810-5 1998 Alignments of LCAT sequences across various species indicate that the four histidines at positions 180, 263, 368, and 377 are conserved and could be involved in catalysis. Histidine 75-85 lecithin-cholesterol acyltransferase Homo sapiens 14-18 9473505-9 1998 In a hip1 tat1 double mutant, the level of histidine required for growth increased eight-fold in comparison to the hip1 single mutant. Histidine 43-52 amino acid transporter TAT1 Saccharomyces cerevisiae S288C 10-14 9510129-0 1998 Proximal and distal histidines in thyroid peroxidase: relation to the alternatively spliced form, TPO-2. Histidine 20-30 thyroid peroxidase Homo sapiens 98-101 9510129-1 1998 The distal and proximal histidines in thyroid peroxidase (TPO), located by amino acid sequence alignment with their known counterparts in myeloperoxidase, are His 239 and His 494, respectively. Histidine 24-34 thyroid peroxidase Homo sapiens 58-61 9510129-1 1998 The distal and proximal histidines in thyroid peroxidase (TPO), located by amino acid sequence alignment with their known counterparts in myeloperoxidase, are His 239 and His 494, respectively. Histidine 159-162 thyroid peroxidase Homo sapiens 58-61 9510129-1 1998 The distal and proximal histidines in thyroid peroxidase (TPO), located by amino acid sequence alignment with their known counterparts in myeloperoxidase, are His 239 and His 494, respectively. Histidine 171-174 thyroid peroxidase Homo sapiens 58-61 9510129-2 1998 These histidines lie outside the 57 amino acid peptide (residues 533-589) that is absent in the alternatively spliced form, TPO-2. Histidine 6-16 thyroid peroxidase Homo sapiens 124-127 9510129-3 1998 However, asparagine 579, which very likely forms a stabilizing hydrogen bond with the proximal histidine in TPO, lies within the missing peptide region. Histidine 95-104 thyroid peroxidase Homo sapiens 108-111 9398308-0 1997 Histidine --> carboxamide ligand substitutions in the zinc binding site of carbonic anhydrase II alter metal coordination geometry but retain catalytic activity. Histidine 0-9 carbonic anhydrase 2 Homo sapiens 78-99 9398308-1 1997 The catalytic zinc ion of human carbonic anhydrase II (CAII) is coordinated by three histidine ligands (H94, H96, and H119) and a hydroxide ion with tetrahedral geometry. Histidine 85-94 carbonic anhydrase 2 Homo sapiens 32-53 9398308-1 1997 The catalytic zinc ion of human carbonic anhydrase II (CAII) is coordinated by three histidine ligands (H94, H96, and H119) and a hydroxide ion with tetrahedral geometry. Histidine 85-94 carbonic anhydrase 2 Homo sapiens 55-59 9353323-5 1997 The Tyr-701 mutant (followed by the His-713 mutant) were most effective in disabling Stat1 function and in overcoming the activating effect of cotransfected wild-type Stat1 in this cell system thereby highlighting the effectiveness of blocking Stat1 homo- and hetero-dimerization. Histidine 36-39 signal transducer and activator of transcription 1 Homo sapiens 85-90 9353323-5 1997 The Tyr-701 mutant (followed by the His-713 mutant) were most effective in disabling Stat1 function and in overcoming the activating effect of cotransfected wild-type Stat1 in this cell system thereby highlighting the effectiveness of blocking Stat1 homo- and hetero-dimerization. Histidine 36-39 signal transducer and activator of transcription 1 Homo sapiens 167-172 9353323-5 1997 The Tyr-701 mutant (followed by the His-713 mutant) were most effective in disabling Stat1 function and in overcoming the activating effect of cotransfected wild-type Stat1 in this cell system thereby highlighting the effectiveness of blocking Stat1 homo- and hetero-dimerization. Histidine 36-39 signal transducer and activator of transcription 1 Homo sapiens 167-172 9353323-7 1997 Then by transfecting hTBECs with wild-type or mutant Stat1 tagged with a Flag reporter sequence, we used dual immunofluorescence to show that hTBECs expressing the Tyr-701 or His-713 mutants were prevented from expressing endogenous ICAM-1 in response to IFN-gamma treatment. Histidine 175-178 signal transducer and activator of transcription 1 Homo sapiens 53-58 9389442-5 1997 A single amino acid difference, either arginine (R) or histidine (H) at amino acid position 131, underlies differential interaction with mIgG1. Histidine 55-64 LOC105243590 Mus musculus 137-142 22358898-0 1997 Preparation of recombinant six-histidine-tagged human LECT2, a chemotactic protein to neutrophils, in Escherichia coli. Histidine 31-40 leukocyte cell derived chemotaxin 2 Homo sapiens 54-59 22358898-2 1997 A recombinant six-histidine-tagged human LECT2, (His)(6)-LECT2, was expressed in E. coli using a pET21a(+) vector. Histidine 18-27 leukocyte cell derived chemotaxin 2 Homo sapiens 41-46 22358898-2 1997 A recombinant six-histidine-tagged human LECT2, (His)(6)-LECT2, was expressed in E. coli using a pET21a(+) vector. Histidine 18-27 leukocyte cell derived chemotaxin 2 Homo sapiens 57-62 9359580-2 1997 The gene product is a 271 amino acid protein that contains the conserved serine, histidine and aspartic acid residues found in serine proteases, and has the highest identity to a serine protease of unknown function from Drosophila melanogaster. Histidine 81-90 Jonah 99Ci Drosophila melanogaster 127-142 9305893-13 1997 These results suggest that His-150 may be the base that abstracts the alpha-proton of the substrate, leading to formation of the quinonoid intermediate in the reaction catalyzed by SHMT. Histidine 27-30 serine hydroxymethyltransferase, cytosolic Ovis aries 181-185 9342227-3 1997 In this study, we have expressed and affinity purified recombinant dCK, using the pET 9d vector system with a histidine tag-sequence and a thrombin cleavage site fused to the N-terminus of the dCK coding sequence. Histidine 110-119 Calcium/calmodulin-dependent protein kinase II Drosophila melanogaster 67-70 9220017-3 1997 The PTHrP encoded sequences were thereby fused at their NH2-termini to six histidine residues within the fusion protein. Histidine 75-84 parathyroid hormone-like hormone Rattus norvegicus 4-9 9220017-4 1997 The recombinant plasmids were transfected into E. coli cells and PTHrP synthesis was induced by addition of 1 mM isopropyl-beta-D-thiogalactopyranoside (IPTG) at 37 degrees C. The recombinant fusion proteins were purified by binding of the histidine residues to a nickel column followed by gradient elusion and dialysis. Histidine 240-249 parathyroid hormone-like hormone Rattus norvegicus 65-70 9189046-3 1997 A point mutation was identified in all of them at position 101 of the gene for alpha-TTP, where histidine (CAT) was replaced with glutamine (CAG). Histidine 96-105 alpha tocopherol transfer protein Homo sapiens 79-88 9266477-1 1997 The structure of neuromedin C, a 10-residue bombesin-like neuropeptide with the sequence Gly-Asn-His-Trp-Ala-Val-Gly-His-Leu-Met-NH2, has been investigated. Histidine 97-100 gastrin releasing peptide Homo sapiens 17-29 9215578-3 1997 Cloning and expression of the TIMP-3 were performed in Escherichia coli as a fusion protein with a 36 amino acid N-tail containing a His cluster. Histidine 133-136 TIMP metallopeptidase inhibitor 3 Homo sapiens 30-36 9108299-7 1997 In contrast to cathepsins L, S, K, B, H and O, cathepsin W contains a 21-amino acid peptide insertion between the putative active site histidine and asparagine residues and an 8-amino acid C-terminal extension. Histidine 135-144 cathepsin W Homo sapiens 47-58 9060645-6 1997 Based on data from site-directed mutagenesis combined with zinc content determination, we propose that Cys-97, Cys-99, Cys-145, and His-149 coordinate the structural zinc in the HCV NS3 proteinase. Histidine 132-135 KRAS proto-oncogene, GTPase Homo sapiens 182-185 9126358-2 1997 Histidine-tagged full-length hVDR was overexpressed in E.coli and purified to near homogeneity using Ni-NTA and gel filtration columns without denature/renature procedures. Histidine 0-9 vitamin D receptor Homo sapiens 29-33 9045649-4 1997 Functional recombinant RF-C containing p40-his, p37-his, or p36-his was isolated using affinity resin. Histidine 43-46 replication factor C subunit 1 Homo sapiens 23-27 9045649-4 1997 Functional recombinant RF-C containing p40-his, p37-his, or p36-his was isolated using affinity resin. Histidine 52-55 replication factor C subunit 1 Homo sapiens 23-27 9045649-4 1997 Functional recombinant RF-C containing p40-his, p37-his, or p36-his was isolated using affinity resin. Histidine 52-55 replication factor C subunit 1 Homo sapiens 23-27 9360711-4 1997 The K(app) for PIP2 was 142 +/- 11 and 156 +/- 12 microM for His.PLC delta 3 and PLC delta 3, respectively. Histidine 61-64 phospholipase C delta 3 Homo sapiens 65-76 9242908-2 1997 These structures reveal that the B12 cofactor undergoes a major conformational change on binding to the apoenzymes of methionine synthase and methylmalonyl-coenzyme A mutase: The dimethylbenzimidazole ligand to the cobalt is displaced by a histidine residue from the protein. Histidine 240-249 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 118-137 9242908-2 1997 These structures reveal that the B12 cofactor undergoes a major conformational change on binding to the apoenzymes of methionine synthase and methylmalonyl-coenzyme A mutase: The dimethylbenzimidazole ligand to the cobalt is displaced by a histidine residue from the protein. Histidine 240-249 methylmalonyl-CoA mutase Homo sapiens 142-173 9242908-6 1997 In methionine synthase, the best studied of the methyltransferases, the histidine ligand appears to be required for competent methyl transfer between methyl-tetrahydrofolate and homocysteine but dissociates for reductive reactivation of the inactive oxidized enzyme. Histidine 72-81 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 3-22 9242908-8 1997 The best-characterized B12-dependent mutases that catalyze carbon skeleton rearrangement, for which methylmalonyl-coenzyme A mutase is the prototype, also bind cobalamin cofactors with histidine as the cobalt ligand, although other cobalamin-dependent mutases do not appear to utilize histidine ligation. Histidine 185-194 methylmalonyl-CoA mutase Homo sapiens 100-131 9242908-8 1997 The best-characterized B12-dependent mutases that catalyze carbon skeleton rearrangement, for which methylmalonyl-coenzyme A mutase is the prototype, also bind cobalamin cofactors with histidine as the cobalt ligand, although other cobalamin-dependent mutases do not appear to utilize histidine ligation. Histidine 285-294 methylmalonyl-CoA mutase Homo sapiens 100-131 9533030-5 1997 Histidine residues, which are possible heme axial ligands in cytochrome b of complex II, were found in the second transmembrane segment of each subunit. Histidine 0-9 mitochondrially encoded cytochrome b Homo sapiens 61-73 9238644-3 1997 The histidine-epsilon-amino caproic acid-beta-alanine-histidine (His-epsilon Ahx-beta Ala-His) sequence was found to yield optimal inhibition of both MMP-2 and MMP-9. Histidine 65-68 matrix metallopeptidase 9 Homo sapiens 160-165 9392828-4 1997 We report that intact rat pro CCK was produced with an amino-terminal His-Tag in e. coli, and it was secreted from sf9 and other insect cells infected with a recombinant baculovirus vector. Histidine 70-73 cholecystokinin Rattus norvegicus 30-33 9606726-5 1997 A histidine at position 260 in the melanocortin-4 receptor is important for normal receptor function. Histidine 2-11 melanocortin 4 receptor Rattus norvegicus 35-58 8973195-1 1996 The five cysteines closest to the carboxyl terminus of human ferrochelatase have been individually mutated to serine, histidine, or aspartate residues in an attempt to identify the protein ligands to the [2Fe-2S] cluster. Histidine 118-127 ferrochelatase Homo sapiens 61-75 8975710-4 1996 The predicted human DYRK and murine Dyrk proteins both contain a nuclear targeting signal sequence, a protein kinase domain, a putative leucine zipper motif, and a highly conserved 13-consecutive-histidine repeat. Histidine 196-205 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a Mus musculus 36-40 9016654-3 1996 TIF1 beta, TIF1 alpha, PML and efp belong to a characteristic subgroup of RING finger proteins that contain one or two other Cys/His-rich clusters (B boxes) and a putative coiled-coil in addition to the classical C3HC4 RING finger motif (RBCC configuration). Histidine 129-132 tripartite motif containing 24 Homo sapiens 11-21 8863827-6 1996 Induction of a pheromone-responsive FUS1-HIS3 reporter gene in far1 his3 cells permits cell growth in medium lacking histidine. Histidine 117-126 imidazoleglycerol-phosphate dehydratase HIS3 Saccharomyces cerevisiae S288C 41-45 8863827-6 1996 Induction of a pheromone-responsive FUS1-HIS3 reporter gene in far1 his3 cells permits cell growth in medium lacking histidine. Histidine 117-126 cyclin-dependent protein serine/threonine kinase inhibiting protein FAR1 Saccharomyces cerevisiae S288C 63-67 8863827-6 1996 Induction of a pheromone-responsive FUS1-HIS3 reporter gene in far1 his3 cells permits cell growth in medium lacking histidine. Histidine 117-126 imidazoleglycerol-phosphate dehydratase HIS3 Saccharomyces cerevisiae S288C 68-72 8831696-4 1996 We show that two histidines and a glutamic acid in the H-E-X-G-H motif and a glutamic acid 25 residues from the second histidine are essential for MIP function in vivo. Histidine 17-27 mitochondrial intermediate peptidase Homo sapiens 147-150 8831696-4 1996 We show that two histidines and a glutamic acid in the H-E-X-G-H motif and a glutamic acid 25 residues from the second histidine are essential for MIP function in vivo. Histidine 17-26 mitochondrial intermediate peptidase Homo sapiens 147-150 8848048-5 1996 Binding occurs between the first cysteine-histidine-rich region of p300/CBP and the carboxy-terminal segment of Stat2, a domain essential for ISGF3 function. Histidine 42-51 signal transducer and activator of transcription 2 Homo sapiens 112-117 8848048-5 1996 Binding occurs between the first cysteine-histidine-rich region of p300/CBP and the carboxy-terminal segment of Stat2, a domain essential for ISGF3 function. Histidine 42-51 signal transducer and activator of transcription 2 Homo sapiens 142-147 8836129-0 1996 Histidine residues in rabbit liver microsomal cytochrome P-450 2B4 control electron transfer from NADPH-cytochrome P-450 reductase and cytochrome b5. Histidine 0-9 NADPH--cytochrome P450 reductase Oryctolagus cuniculus 98-130 8836129-0 1996 Histidine residues in rabbit liver microsomal cytochrome P-450 2B4 control electron transfer from NADPH-cytochrome P-450 reductase and cytochrome b5. Histidine 0-9 cytochrome b5 Oryctolagus cuniculus 135-148 8836175-2 1996 The open reading frame of RNase k6, amplified from human genomic DNA, encodes a 150 amino acid polypeptide with eight cysteines and histidine and lysine residues corresponding to those found in the active site of the prototype, ribonuclease A. Histidine 132-141 ribonuclease A family member k6 Homo sapiens 26-34 8886274-2 1996 An intrinsic fluorescence study showed that the tryptophan residues at position 13 and 85 within CRP were located in an internal, nonpolar environment, and the conformational change induced by the binding of cAMP occurred around the tryptophan residue NMR experiment has manifested that the comformational change around the tryptophan residue at position 85 and histidine residue at position 159 of CRP is induced by the binding of cAMP. Histidine 362-371 catabolite gene activator protein Escherichia coli 97-100 8886274-2 1996 An intrinsic fluorescence study showed that the tryptophan residues at position 13 and 85 within CRP were located in an internal, nonpolar environment, and the conformational change induced by the binding of cAMP occurred around the tryptophan residue NMR experiment has manifested that the comformational change around the tryptophan residue at position 85 and histidine residue at position 159 of CRP is induced by the binding of cAMP. Histidine 362-371 catabolite gene activator protein Escherichia coli 399-402 8781408-9 1996 However, the binding of BCR/abl to p85 SH2 domains was abolished in cells expressing mutant, temperature-sensitive (ts) p210 BCR/abl in which the tyrosine in the YXXM motif of p210 BCR/abl was replaced by histidine. Histidine 205-214 c-abl oncogene 1, non-receptor tyrosine kinase Mus musculus 28-31 8781408-9 1996 However, the binding of BCR/abl to p85 SH2 domains was abolished in cells expressing mutant, temperature-sensitive (ts) p210 BCR/abl in which the tyrosine in the YXXM motif of p210 BCR/abl was replaced by histidine. Histidine 205-214 envoplakin Mus musculus 120-124 8781408-9 1996 However, the binding of BCR/abl to p85 SH2 domains was abolished in cells expressing mutant, temperature-sensitive (ts) p210 BCR/abl in which the tyrosine in the YXXM motif of p210 BCR/abl was replaced by histidine. Histidine 205-214 envoplakin Mus musculus 176-180 8703082-5 1996 The mammalian Scip gene had alanine, glycine, proline, and histidine repeats, but the nonmammalian homologue completely lacked these repeats. Histidine 59-68 POU class 3 homeobox 1 Homo sapiens 14-18