PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
2765563-8	1989	A synthetic peptide Lys-Thr-Gly-deoxyhypusine-His-Gly-His-Ala-Lys, the amino acid sequence of which corresponds to that surrounding hypusine in eukaryotic initiation factor 4D, was found to display competitive-type inhibition (Ki, 0.44 +/- 0.02 mM) against deoxyhypusine hydroxylase from Chinese hamster ovary cells.	Histidine	46-49	deoxyhypusine hydroxylase	Cricetulus griseus	257-282
2633803-4	1989	A comparison of these results with earlier obtained data on the functional properties, of immobilized antibodies revealed that the decrease of antigen-binding characteristics of anti-CEA after IgG immobilization via NH2- and COOH-groups, carbohydrate moiety, tyrosine and histidine residues is due to the direct effect of antibody modification, whereas the changes in parameters of antibody interaction with antigen after IgG immobilization via SH-groups, methionine and histidine residues is due to steric hindrances.	Histidine	272-281	CEA cell adhesion molecule 3	Homo sapiens	183-186
2633803-4	1989	A comparison of these results with earlier obtained data on the functional properties, of immobilized antibodies revealed that the decrease of antigen-binding characteristics of anti-CEA after IgG immobilization via NH2- and COOH-groups, carbohydrate moiety, tyrosine and histidine residues is due to the direct effect of antibody modification, whereas the changes in parameters of antibody interaction with antigen after IgG immobilization via SH-groups, methionine and histidine residues is due to steric hindrances.	Histidine	471-480	CEA cell adhesion molecule 3	Homo sapiens	183-186
2636901-1	1989	Rabbit histidine-rich glycoprotein (HRG) binds low-spin heme and metals tightly at several sites that contain histidine.	Histidine	7-16	histidine-rich glycoprotein	Oryctolagus cuniculus	36-39
2636901-2	1989	As part of an on-going effort to define and locate the binding sites for these and the other ligands of HRG, the sequence: NH2-Gly-His-Phe-Pro-Phe-His-Trp-... was found in a 16 kDa heme-binding peptide isolated from HRG.	Histidine	131-134	histidine-rich glycoprotein	Oryctolagus cuniculus	104-107
2636901-2	1989	As part of an on-going effort to define and locate the binding sites for these and the other ligands of HRG, the sequence: NH2-Gly-His-Phe-Pro-Phe-His-Trp-... was found in a 16 kDa heme-binding peptide isolated from HRG.	Histidine	131-134	histidine-rich glycoprotein	Oryctolagus cuniculus	216-219
2812284-1	1989	The drug SK&F 110679 (His-D-Trp-Ala-Trp-D-Phe-LysNH2), is an enkephalin-derived hexapeptide, which specifically releases growth hormone in a wide variety of species in vivo and in vitro.	Histidine	26-29	growth hormone 1	Homo sapiens	125-139
2558710-0	1989	Identification by proton nuclear magnetic resonance of the histidines in cytochrome b5 modified by diethyl pyrocarbonate.	Histidine	59-69	cytochrome b5 type A	Bos taurus	73-86
2692616-1	1989	For hexamer formation of native insulin the repulsive potential of six B13 Glu carboxylate groups coming together in the centre is overcome by zinc binding to B10 His.	Histidine	163-166	insulin	Homo sapiens	32-39
2692616-5	1989	The structural transformation of insulin can thus be brought about in two ways: By inorganic ions with the zinc ions as their points of attack, which preexist in the nontransformed hexamer, and by phenol, for which the binding sites close to the B5 histidines come into existence only with the transformation.	Histidine	249-259	insulin	Homo sapiens	33-40
2554286-11	1989	The testis enzyme contains the second of the two putative metal-binding sites (His-Glu-Met-Gly-His) identified in endothelial ACE.	Histidine	79-82	angiotensin I converting enzyme	Homo sapiens	126-129
2554286-11	1989	The testis enzyme contains the second of the two putative metal-binding sites (His-Glu-Met-Gly-His) identified in endothelial ACE.	Histidine	95-98	angiotensin I converting enzyme	Homo sapiens	126-129
2520246-1	1989	Fast-atom bombardment mass spectrometry of a synthetic renin substrate decapeptide (Pro-His-Pro-Phe-His-Leu-Val-Ile-His-D-Lys) indicated the presence of several side-products, including a component 12 Da higher in mass.	Histidine	88-91	renin	Homo sapiens	55-60
2520246-1	1989	Fast-atom bombardment mass spectrometry of a synthetic renin substrate decapeptide (Pro-His-Pro-Phe-His-Leu-Val-Ile-His-D-Lys) indicated the presence of several side-products, including a component 12 Da higher in mass.	Histidine	100-103	renin	Homo sapiens	55-60
2765563-8	1989	A synthetic peptide Lys-Thr-Gly-deoxyhypusine-His-Gly-His-Ala-Lys, the amino acid sequence of which corresponds to that surrounding hypusine in eukaryotic initiation factor 4D, was found to display competitive-type inhibition (Ki, 0.44 +/- 0.02 mM) against deoxyhypusine hydroxylase from Chinese hamster ovary cells.	Histidine	54-57	deoxyhypusine hydroxylase	Cricetulus griseus	257-282
2788281-6	1989	Comparison of these sequences suggests that two Abeta residues, His-47 and Trp-197, are important to the transmission of differentiative signals to B cells.	Histidine	64-67	histocompatibility 2, class II antigen A, beta 1	Mus musculus	48-53
2778547-1	1989	Acute histidinemia was provoked in 30-d-old male Wistar rats by injecting intraperitoneally either histidine alone (0.5 mg/g body wt) or histidine (0.25 mg/g body wt) plus the histidase inhibitor nitromethane (0.73 mg/g body wt).	Histidine	6-15	histidine ammonia lyase	Rattus norvegicus	176-185
2777088-5	1989	However, the predicted amino acid sequences of the encoded LOX enzymes show certain conserved regions that are presumably involved in their catalytic activity, in particular a cluster of five conserved histidines that we predict chelate the iron moiety involved in the active site.	Histidine	202-212	seed linoleate 9S-lipoxygenase-3	Glycine max	59-62
2775751-9	1989	The active site histidine, His-186, is hydrogen bonded from nitrogen ND1 to the carboxylate of Asp-158 and from its nitrogen NE2 to the sulfate ion bound in the putative substrate binding site.	Histidine	16-25	NADH dehydrogenase subunit 1	Sus scrofa	69-72
2775751-9	1989	The active site histidine, His-186, is hydrogen bonded from nitrogen ND1 to the carboxylate of Asp-158 and from its nitrogen NE2 to the sulfate ion bound in the putative substrate binding site.	Histidine	27-30	NADH dehydrogenase subunit 1	Sus scrofa	69-72
2471521-1	1989	(-)mRNA complementary to human angiotensin II (+)mRNA encodes the "antipeptide" Glu-Gly-Val-Tyr-Val-His-Pro-Val which is structurally related to angiotensin II.	Histidine	100-103	angiotensinogen	Homo sapiens	31-45
2499045-1	1989	The hydrogen-bonding status of His57 in the catalytic triad (Asp-His-Ser) of serine protease has important mechanistic implications for this class of enzymes.	Histidine	31-34	coagulation factor II, thrombin	Homo sapiens	77-92
2471521-1	1989	(-)mRNA complementary to human angiotensin II (+)mRNA encodes the "antipeptide" Glu-Gly-Val-Tyr-Val-His-Pro-Val which is structurally related to angiotensin II.	Histidine	100-103	angiotensinogen	Homo sapiens	145-159
2659073-0	1989	Role of the histidine 176 residue in glyceraldehyde-3-phosphate dehydrogenase as probed by site-directed mutagenesis.	Histidine	12-21	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	37-77
2546145-2	1989	TNF contains three histidine residues, located at positions 15, 73 and 78.	Histidine	19-28	tumor necrosis factor	Homo sapiens	0-3
2546145-3	1989	The histidine-specific reagent diethylpyrocarbonate (DEP) was used to chemically modify TNF.	Histidine	4-13	tumor necrosis factor	Homo sapiens	88-91
2546145-10	1989	The data show that the histidine residue at position 15 is an amino acid that is required for the cytotoxic activity of TNF.	Histidine	23-32	tumor necrosis factor	Homo sapiens	120-123
2784963-0	1989	Induction of histidine and ornithine decarboxylase activities in mouse tissues by recombinant interleukin-1 and tumor necrosis factor.	Histidine	13-22	tumor necrosis factor	Mus musculus	94-133
2659073-1	1989	The catalytically essential amino acid, histidine 176, in the active site of Escherichia coli glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has been replaced with an asparagine residue by site-directed mutagenesis.	Histidine	40-49	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	94-134
2659073-1	1989	The catalytically essential amino acid, histidine 176, in the active site of Escherichia coli glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has been replaced with an asparagine residue by site-directed mutagenesis.	Histidine	40-49	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	136-141
2537662-2	1989	The derivatization of catalase resulted in coupling the long-chain fatty acyl residues to lysine, histidine and arginine, while other amino acids remained essentially unaffected.	Histidine	98-107	catalase	Rattus norvegicus	22-30
2542448-0	1989	ESR studies of the interaction of copper(II)GHK, histidine, and Ehrlich cells.	Histidine	49-58	esterase 5 regulator	Mus musculus	0-3
2542448-3	1989	ESR spectra are used to characterize adduct formation between CuGHK and histidine.	Histidine	72-81	esterase 5 regulator	Mus musculus	0-3
2563380-11	1989	This conclusion is supported also by direct amino acid analysis of acid hydrolysates which shows that the oxidation of glutamine synthetase, enolase, and phosphoglycerate kinase is associated with the loss of at least 1 histidine residue per subunit.	Histidine	220-229	Enolase	Escherichia coli	141-148
2743502-2	1989	However, we observed a serious side reaction caused by the Ac2O capping procedure, when it was applied to a synthesis of a peptide containing His.	Histidine	142-145	adenylate cyclase 2	Homo sapiens	59-62
2719939-12	1989	The enhanced enzymatic properties of ARH-I parallel a 2-fold increase in chemical reactivity of active-site lysine and histidine residues based on rates of chemical modification.	Histidine	119-128	low density lipoprotein receptor adaptor protein 1	Homo sapiens	37-40
2469648-1	1989	Monoclonal antibodies (MAB) were developed which recognize a peptide, His-Glu-Ala-Pro-Ile (HEAPI), encoded by the RNA complementary to the mRNA specifying [Met]-enkephalin.	Histidine	70-73	proopiomelanocortin	Homo sapiens	156-171
2909523-11	1989	In a less active variant of human GH, hGH-V, only 1 residue (His-21) of the 37 residues is replaced by Tyr.	Histidine	61-64	growth hormone 1	Homo sapiens	34-36
2649638-5	1989	High molecular weights and the observed glutamic acid/histidine ratios in Cr(III) containing peptides have been rationalized in terms of Cr(III) being associated with insulin aggregates rather than the monomer of the protein.	Histidine	54-63	insulin	Homo sapiens	167-174
2535849-9	1989	We attribute the acid/alkaline transition in the ferrous forms of cytochrome c peroxidase to a rearrangement mainly of the proximal side of the heme, culminating in a change of steric interactions between the proximal histidine and the heme or of the hydrogen bonding network involving the proximal histidine.	Histidine	218-227	cytochrome c, somatic	Homo sapiens	66-78
2535849-9	1989	We attribute the acid/alkaline transition in the ferrous forms of cytochrome c peroxidase to a rearrangement mainly of the proximal side of the heme, culminating in a change of steric interactions between the proximal histidine and the heme or of the hydrogen bonding network involving the proximal histidine.	Histidine	299-308	cytochrome c, somatic	Homo sapiens	66-78
2619739-0	1989	Psychotropic activity of angiotensin II and its fragments Val-Tyr-Ile-NH2 and Val-Tyr-Ile-His-NH2.	Histidine	90-93	angiotensinogen	Rattus norvegicus	25-39
2552247-4	1989	Tryptic mapping of nexly synthetized alpha-MSH generated two fragments with the following amino acid composition: (T1) Trp, Pro, Lys, Gly, Val and (T2) Tyr, Arg, Phe, His, Ser, Glu.	Histidine	167-170	proopiomelanocortin	Homo sapiens	37-46
2561912-5	1989	VIP and VIP-related peptides competed for 125I-VIP binding in the following order of potency: human (h) VIP greater than human peptide with N-terminal histidine and C-terminal methionine (PHM) greater than chicken secretin much greater than porcine secretin.	Histidine	151-160	vasoactive intestinal peptide	Homo sapiens	0-3
2561912-5	1989	VIP and VIP-related peptides competed for 125I-VIP binding in the following order of potency: human (h) VIP greater than human peptide with N-terminal histidine and C-terminal methionine (PHM) greater than chicken secretin much greater than porcine secretin.	Histidine	151-160	vasoactive intestinal peptide	Homo sapiens	8-11
2561912-5	1989	VIP and VIP-related peptides competed for 125I-VIP binding in the following order of potency: human (h) VIP greater than human peptide with N-terminal histidine and C-terminal methionine (PHM) greater than chicken secretin much greater than porcine secretin.	Histidine	151-160	vasoactive intestinal peptide	Homo sapiens	8-11
2561912-5	1989	VIP and VIP-related peptides competed for 125I-VIP binding in the following order of potency: human (h) VIP greater than human peptide with N-terminal histidine and C-terminal methionine (PHM) greater than chicken secretin much greater than porcine secretin.	Histidine	151-160	vasoactive intestinal peptide	Homo sapiens	8-11
2461903-7	1989	Four other residues in the first or second external domains of HLA-A29.1 (thr-9, leu-62, gln-63, and his-102) were unique among the HLA-A alleles, but none of these was found in corresponding positions of HLA-B of -C alleles and thus failed to correlate with presence or absence of the 4E determinant.	Histidine	101-104	major histocompatibility complex, class I, A	Homo sapiens	63-68
2535874-1	1989	alpha-Melanocyte stimulating hormone (alpha-MSH) is a linear tridecapeptide (Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2) that has diverse physiological functions in addition to its reversible darkening of amphibian skins by stimulating melanosome dispersion within melanophores.	Histidine	100-103	alpha-msh	Anolis carolinensis	0-36
2535874-1	1989	alpha-Melanocyte stimulating hormone (alpha-MSH) is a linear tridecapeptide (Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2) that has diverse physiological functions in addition to its reversible darkening of amphibian skins by stimulating melanosome dispersion within melanophores.	Histidine	100-103	alpha-msh	Anolis carolinensis	38-47
2555283-15	1989	The mechanisms by which arginine- and histidine-rich polyelectrolytes activate the respiratory burst in neutrophils might involve interaction with G-proteins, the activation of arachidonic acid metabolism and phospholipase A2, or the interaction with myeloperoxidase.	Histidine	38-47	phospholipase A2 group IB	Homo sapiens	209-225
2555283-15	1989	The mechanisms by which arginine- and histidine-rich polyelectrolytes activate the respiratory burst in neutrophils might involve interaction with G-proteins, the activation of arachidonic acid metabolism and phospholipase A2, or the interaction with myeloperoxidase.	Histidine	38-47	myeloperoxidase	Homo sapiens	251-266
3252892-4	1988	The most strongly associated interaction is the chelation of iron by transferrin, with an association constant of approximately 10(21); tyrosines, histidines, and sometimes aspartate are involved.	Histidine	147-157	transferrin	Homo sapiens	69-80
2699758-3	1989	Vasoactive intestinal polypeptide (VIP) and peptide with N- and C-terminal histidine (PHI) are released together with acetylcholine from parasympathetic nerves.	Histidine	75-84	vasoactive intestinal peptide	Homo sapiens	0-33
2699758-3	1989	Vasoactive intestinal polypeptide (VIP) and peptide with N- and C-terminal histidine (PHI) are released together with acetylcholine from parasympathetic nerves.	Histidine	75-84	vasoactive intestinal peptide	Homo sapiens	35-38
3076850-2	1988	It is related to several other peptides including PHI (peptide with N-terminal histidine and C-terminal isoleucine amide), secretin, glucagon, and has some sequences similar to those of growth hormone releasing hormone (Fig.	Histidine	79-88	growth hormone releasing hormone	Homo sapiens	186-218
3076850-5	1988	It has been shown that human VIP is cosynthesized with PHM (peptide with N-terminal histidine and C-terminal methionine amide, the human analogue of PHI) from the same large precursor protein (Itoh et al., 1983).	Histidine	84-93	vasoactive intestinal peptide	Homo sapiens	29-32
2562482-1	1989	Novel D-amino acid modified, hexapeptide inhibitors of alpha-melanocyte-stimulating hormone (Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2, alpha-MSH) are described.	Histidine	116-119	alpha-msh	Anolis carolinensis	153-162
3233203-4	1988	Group-specific modification of either arginine, lysine, or histidine residues of bindin results in a substantial inactivation of fucan binding activity.	Histidine	59-68	bindin	Strongylocentrotus purpuratus	81-87
2850465-3	1988	Under conditions in which his4-912 delta confers a His- phenotype.	Histidine	51-54	trifunctional histidinol dehydrogenase/phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase	Saccharomyces cerevisiae S288C	26-30
2850465-11	1988	The two strongest His+ mutants of this class synthesize the wild-type HIS4 transcript at levels consistent with their His+ phenotype.	Histidine	18-21	trifunctional histidinol dehydrogenase/phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase	Saccharomyces cerevisiae S288C	70-74
2850465-11	1988	The two strongest His+ mutants of this class synthesize the wild-type HIS4 transcript at levels consistent with their His+ phenotype.	Histidine	18-22	trifunctional histidinol dehydrogenase/phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase	Saccharomyces cerevisiae S288C	70-74
2844821-7	1988	It is concluded that Ser-Lys-Thr-Ala-Ser-Pro-Trp-Lys-Ser-Ala-Arg-Leu-Met-Val-His-Thr-Val-Ala- Thr- Phe-Asn-Ser-Ile-Lys, a 24-residue peptide which bridges repeats 11 and 12 of brain alpha spectrin contains the high affinity calmodulin binding domain.	Histidine	77-80	calmodulin 1	Homo sapiens	224-234
3233203-5	1988	Preincubation of bindin with fucan can almost completely protect bindin from inactivation by arginine-specific reagents, butanedione and phenylglyoxal, but only moderately slowed the inactivation by the histidine reagent diethyl pyrocarbonate.	Histidine	203-212	bindin	Strongylocentrotus purpuratus	17-23
3177653-4	1988	Furthermore, histidine was additive to naproxen in increasing the hydrosmotic effect of vasopressin, without causing a further decrease in PGE2 production.	Histidine	13-22	arginine vasopressin	Homo sapiens	88-99
3210228-4	1988	When the proximity of the altered amino acid residues to the histidines involved in heme ligation is considered, the results support a model for cytochrome b folding in which there are eight transmembrane domains rather than the nine of the Widger-Saraste model.	Histidine	61-71	cytochrome b, mitochondrial	Mus musculus	145-157
3177653-0	1988	Effects of histidine on vasopressin action: role of decreased prostaglandin production.	Histidine	11-20	arginine vasopressin	Homo sapiens	24-35
3177653-1	1988	Addition of histidine to the serosal bath of the toad bladder increases the hydrosmotic response of vasopressin in this tissue.	Histidine	12-21	arginine vasopressin	Homo sapiens	100-111
3177653-7	1988	We propose that histidine increases the hydrosmotic response to vasopressin through at least two distinct mechanisms: 1) it decreases prostaglandin synthesis and thus increases luminal permeability; 2) it decreases the resistance to water movement of the tissues beneath the luminal membrane.	Histidine	16-25	arginine vasopressin	Homo sapiens	64-75
3177653-2	1988	Because this represents primarily the effect of the imidazole ring of histidine, which is a known inhibitor of the production of prostaglandins, we evaluated whether histidine increases the response to vasopressin through decreased prostaglandin production.	Histidine	166-175	arginine vasopressin	Homo sapiens	202-213
3177653-3	1988	Histidine increases the response to vasopressin much more than 10(-5) M naproxen, even though the latter was equipotent to histidine in reducing prostaglandin E2 (PGE2) production.	Histidine	0-9	arginine vasopressin	Homo sapiens	36-47
3233312-4	1988	The results obtained from spectrofluorometric pH titration of alpha-lactalbumin in the acidic pH region show the possible involvement of histidine residues in the coordination of Cu2+.	Histidine	137-146	lactalbumin alpha	Homo sapiens	62-79
2459697-2	1988	Replacement of Asp-116 in angiogenin by either asparagine (D116N), alanine (D116A), or histidine (D116H) markedly enhances both its ribonucleolytic activity and angiogenic potency.	Histidine	87-96	ribonuclease A family member k6	Gallus gallus	26-36
2459697-5	1988	Thus, cleavage of 18S and 28S rRNA by the most active His-116 mutant yields the same pattern of polynucleotide products as from angiogenin, whereas there are only minor alterations in activity with cytidylyl(3",5")adenosine and uridylyl(3",5")-adenosine.	Histidine	54-57	ribonuclease A family member k6	Gallus gallus	128-138
2842044-3	1988	The neuropeptide and its natural analogues inhibited the binding of 125I-VIP and stimulated cyclic AMP (cAMP) generation in T-47D cells 96-fold (EC50 = 7 X 10(-10) M VIP), in the following order of potency: VIP greater than helodermin greater than human peptide with N-terminal histidine and C-terminal methionine greater than human pancreatic growth hormone-releasing factor greater than human secretin.	Histidine	278-287	vasoactive intestinal peptide	Homo sapiens	73-76
2847349-3	1988	Modification of thrombin at the catalytic site serine and histidine residues, with Diisopropylfluorophosphate and Tosyl-L-lysine chloromethyl ketone, resulted in loss of clotting and amidolytic activity.	Histidine	58-67	coagulation factor II, thrombin	Homo sapiens	16-24
2841485-0	1988	Mutations in Rous sarcoma virus nucleocapsid protein p12 (NC): deletions of Cys-His boxes.	Histidine	80-83	DNA polymerase epsilon 4, accessory subunit	Homo sapiens	53-56
2841485-1	1988	Rous sarcoma virus nucleocapsid protein p12 (NC) contains two conserved amino acid motifs, the Cys-His boxes, which constitute potential metal-binding domains.	Histidine	99-102	DNA polymerase epsilon 4, accessory subunit	Homo sapiens	40-43
3146347-2	1988	Since thrombin has a primary specificity for basic amino acids, each of the three basic residues and the histidine in hirudin were mutated to glutamine.	Histidine	105-114	coagulation factor II, thrombin	Homo sapiens	6-14
2466783-2	1988	This homology is one of six amino acids corresponding to interleukin-2 (IL-2) residues 14-19 (Leu-Glu-His-Leu-Leu-Leu) and to the carboxy terminal six amino acids of HIV envelope protein gp41 (Leu-Glu-Arg-Ile-Leu-Leu).	Histidine	102-105	interleukin 2	Homo sapiens	57-70
2466783-2	1988	This homology is one of six amino acids corresponding to interleukin-2 (IL-2) residues 14-19 (Leu-Glu-His-Leu-Leu-Leu) and to the carboxy terminal six amino acids of HIV envelope protein gp41 (Leu-Glu-Arg-Ile-Leu-Leu).	Histidine	102-105	interleukin 2	Homo sapiens	72-76
3167031-7	1988	The fluorescence increase of papain at alkaline pH, arising from Trp-177 and due to deprotonization of the adjacent His-159, was abolished on binding of cystatin to the enzyme, further supporting the proposal that this region of papain participates in the interaction with the inhibitor.	Histidine	116-119	cystatin C	Gallus gallus	153-161
3421939-3	1988	When filaggrin was labelled in vivo with [3H]histidine and then incubated with rat epidermal preparations, the label was rendered SDS/thiol-insoluble.	Histidine	41-54	filaggrin	Rattus norvegicus	5-14
3390186-5	1988	For the proposed His:Phe interaction in angiotensin II, the attraction will be three times greater when the imidazole ring carries a negative charge.	Histidine	17-20	angiotensinogen	Homo sapiens	40-54
3391168-6	1988	In the presence of Chaps micelles, bovine intact cytochrome b5 was in monomeric form and the histidine signals disappeared from its photo-CIDNP spectrum.	Histidine	93-102	cytochrome b5 type A	Bos taurus	49-62
3410637-3	1988	The changes in the chemical shift and pKs of the C-2 proton resonances of His-12, -48, -119 in the complexes RNase A--dNpdN were smaller than those previously found when the enzyme interacted with mononucleotides.	Histidine	74-77	ribonuclease pancreatic	Bos taurus	109-116
3351849-0	1988	The importance of residues 2 (arginine) and 6 (histidine) in high-affinity angiotensin II antagonists.	Histidine	47-56	angiotensinogen	Homo sapiens	75-89
3351849-1	1988	The structure-antagonist activity relationship is described for analogues of [Sar1,Ile8]angiotensin II substituted in position 2 (arginine) and position 6 (histidine).	Histidine	156-165	angiotensinogen	Homo sapiens	88-102
3351849-3	1988	Evidence is presented suggesting that the position 6 histidine side chain in angiotensin II (AII) is not involved in receptor stimulation.	Histidine	53-62	angiotensinogen	Homo sapiens	77-91
3341778-1	1988	The interactions of diethylpyrocarbonate (DEP) with the various forms of cytochrome b5 were studied to gain a better understanding of the factors that influence the extent of modification of the axial histidines of cytochrome b5.	Histidine	201-211	cytochrome b5 type A	Bos taurus	215-228
3126296-10	1988	We further suggest that the high selectivity of potent renin inhibitors known to be only weak pepsin and cathepsin D inhibitors is due in part to the extent of histidine protonation at P2 arising from pH differences in the inhibition kinetics assay of renin (neutral conditions) compared to other aspartic proteinases (acid pH 2-4).	Histidine	160-169	renin	Homo sapiens	55-60
3126296-10	1988	We further suggest that the high selectivity of potent renin inhibitors known to be only weak pepsin and cathepsin D inhibitors is due in part to the extent of histidine protonation at P2 arising from pH differences in the inhibition kinetics assay of renin (neutral conditions) compared to other aspartic proteinases (acid pH 2-4).	Histidine	160-169	renin	Homo sapiens	252-257
3341778-3	1988	Moreover, it was shown that two additional histidines, presumed to be the axial ligands (His 39 and 63), were modified in the apo but not the holo form of a given preparation of cytochrome b5.	Histidine	43-53	cytochrome b5 type A	Bos taurus	178-191
3341778-9	1988	Examination of the cytochrome b5 molecule by computer graphics indicates that a tunnel leads from the surface of the molecule to axial histidine 63 and that axial histidine 39 is buried.	Histidine	135-144	cytochrome b5 type A	Bos taurus	19-32
3341778-9	1988	Examination of the cytochrome b5 molecule by computer graphics indicates that a tunnel leads from the surface of the molecule to axial histidine 63 and that axial histidine 39 is buried.	Histidine	163-172	cytochrome b5 type A	Bos taurus	19-32
3338452-5	1988	Cationic amino acid residues of hFABP (1 His, 15 Lys, 2 Arg) were screened for ionic fatty acid/protein interactions.	Histidine	41-44	fatty acid binding protein 3	Homo sapiens	32-37
2452461-4	1988	A second peptide His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2 isolated from the extracts is identical to human neurokinin A.	Histidine	17-20	tachykinin precursor 1	Homo sapiens	110-122
2826464-14	1988	However, a 100-residue segment of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (residues 250-349), including the active site histidine residue of the bisphosphatase domain, was found to be homologous to the active site regions of yeast phosphoglycerate mutase and human bisphosphoglycerate mutase.	Histidine	133-142	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	Rattus norvegicus	34-86
3356296-2	1988	Tyrosine and two structural isomers of histidine residues in human haptoglobin were modified with diazotized sulfanilic acid.	Histidine	39-48	haptoglobin	Homo sapiens	67-78
3356297-2	1988	Human haptoglobin (Hp) type 2-1 was subjected to the sulfanilazo-modification of tyrosine and histidine residues, the removal of sialic acid, and the reduction of disulfide bonds (isolation of alpha 2, alpha 1, beta subunits), respectively.	Histidine	94-103	haptoglobin	Homo sapiens	6-17
3275777-7	1988	10-fold) in renin inhibitory activity as exemplified by the pentapeptide Ac-Ftr-Pro-Phe-His-Sta-NH2 (12; IC50 = 3.8 X 10(-9) M).	Histidine	88-91	renin	Homo sapiens	12-17
2832322-2	1987	It was observed that vasoactive intestinal peptide (VIP) and peptide having NH2-terminal histidine and COOH-terminal Isoleucine (PHI) inhibited the incorporation of 3H-methyl-thymidine by cells stimulated with Con A (55% inhibition) or alloantigen-bearing cells (40% inhibition).	Histidine	89-98	vasoactive intestinal polypeptide	Mus musculus	52-55
3426593-4	1987	The pyridoxal 5"-phosphate-binding site has the His-Lys(PLP)-X structure characteristic of known pyridoxal 5"-phosphate-dependent amino acid decarboxylases, tryptophan synthase, and serine hydroxymethyltransferase.	Histidine	48-51	proteolipid protein 1	Gallus gallus	56-59
2840655-5	1988	The residues at 416 in myeloperoxidase and 407 in thyroid peroxidase were estimated as possible candidates for the proximal histidine residues that link to the iron centers of the enzymes.	Histidine	124-133	myeloperoxidase	Homo sapiens	23-38
2840655-8	1988	The possible location of the distal histidine residues in myeloperoxidase and thyroid peroxidase amino acid sequences are also discussed.	Histidine	36-45	myeloperoxidase	Homo sapiens	58-73
2826144-5	1987	In unliganded methemoglobin pK1, which is associated with carboxylic acid groups, ranges between 4.0 and 5.5 for the three methemoglobins; pK2, which is associated with histidines and terminal amino groups, ranges from 6.2 to 6.7.	Histidine	169-179	pyruvate kinase L/R	Homo sapiens	28-31
3427089-0	1987	Further characterization of the interaction of histidine-rich glycoprotein with heparin: evidence for the binding of two molecules of histidine-rich glycoprotein by high molecular weight heparin and for the involvement of histidine residues in heparin binding.	Histidine	47-56	histidine-rich glycoprotein	Oryctolagus cuniculus	134-161
3427089-10	1987	The heparin-HRG interaction is progressively decreased by modification of the histidine residues of HRG, whereas modification of 22 of the 33 lysine residues of HRG has little effect.	Histidine	78-87	histidine-rich glycoprotein	Oryctolagus cuniculus	12-15
3427089-10	1987	The heparin-HRG interaction is progressively decreased by modification of the histidine residues of HRG, whereas modification of 22 of the 33 lysine residues of HRG has little effect.	Histidine	78-87	histidine-rich glycoprotein	Oryctolagus cuniculus	100-103
3427089-10	1987	The heparin-HRG interaction is progressively decreased by modification of the histidine residues of HRG, whereas modification of 22 of the 33 lysine residues of HRG has little effect.	Histidine	78-87	histidine-rich glycoprotein	Oryctolagus cuniculus	100-103
3305946-8	1987	Of these, the inhibitors that contain histidine show marked selectivity toward renin over a related aspartic proteinase, pepsin.	Histidine	38-47	renin	Homo sapiens	79-84
3622513-8	1987	Residue 47 is His in beta 2 and Arg in the beta 1, gamma 1, and gamma 2 subunits, and in horse liver alcohol dehydrogenase.	Histidine	14-17	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	43-49
3622513-8	1987	Residue 47 is His in beta 2 and Arg in the beta 1, gamma 1, and gamma 2 subunits, and in horse liver alcohol dehydrogenase.	Histidine	14-17	tryptophanyl-tRNA synthetase 1	Homo sapiens	64-71
3622513-9	1987	Both His and Arg can make a hydrogen bond to a phosphate oxygen atom of NAD; hence the lower turnover rate of beta 1 apparently derives from a charge effect.	Histidine	5-8	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	110-116
3302105-7	1987	The N-terminal amino acid sequence of CSF gamma-Aogen was Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-Leu-Leu-Val-Tyr-Ser-Lys-Ser-Ser-(X)-Glu- .	Histidine	78-81	angiotensinogen	Canis lupus familiaris	48-53
3663613-3	1987	Modification of the active-site histidine with D-Phe-Pro-Arg-CH2Cl resulted in a form of thrombin with a 10(6)-fold reduced affinity for hirudin.	Histidine	32-41	coagulation factor II, thrombin	Homo sapiens	89-97
2897102-3	1987	Sequencing of the mutant v-erbB gene revealed a single amino acid change of a histidine to an aspartate residue at a position equivalent to amino-acid 826 of the human epidermal growth factor receptor.	Histidine	78-87	epidermal growth factor receptor	Homo sapiens	168-200
3603027-5	1987	The ornithine transcarbamylase gene in the sparse fur mouse contains a C to A transversion that alters a histidine residue to an asparagine residue at amino acid 117.	Histidine	105-114	ornithine transcarbamylase	Mus musculus	4-30
2890553-2	1987	We showed previously that the transcript from an actin-HIS4 gene fusion containing the mutation TACTAAC to TACTACC (designated C259) is spliced inefficiently, thereby preventing growth on the histidine precursor histidinol.	Histidine	192-201	trifunctional histidinol dehydrogenase/phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase	Saccharomyces cerevisiae S288C	55-59
3657775-6	1987	The following values of kinetic parameters for the modification of pyruvate dehydrogenase component by diethylpyrocarbonate were obtained (pH 6.0; 20 degrees C): k1 = 6400 +/- 400 M-1 min-1 (the microscopic rate constant for the modification of histidine residue in the intact dimer), k2 = 890 +/- 200 M-1 min-1 (the rate constant for the modification of histidine residue in the intact subunit in the dimer which contains one modified subunit) and kt = 0.9 +/- 0.2 min-1 (the rate constant for conformational transition of the dimer induced by modification of histidine residue in one of the subunits in the dimeric molecule).	Histidine	245-254	CD59 molecule (CD59 blood group)	Homo sapiens	184-189
2439086-5	1987	The analogues containing additionally Sar or His in the position 9 showed a complete lack of both: hypotensive activity and expression of the antigenic determinant of Substance P.	Histidine	45-48	tachykinin precursor 1	Homo sapiens	167-178
3108248-6	1987	The sequence of the propeptide (Arg-Ser-Phe-Trp-Gln-His) differs in two positions from that of mammalian apoA-I.	Histidine	52-55	apolipoprotein A1	Homo sapiens	105-111
3584128-9	1987	Since little change in the rate of the heparin-catalyzed inhibition of thrombin by antithrombin occurs in this pH region, the dramatic change in HRG inhibition seen upon pH titration may reflect increasing ionic interaction between heparin and HRG due to the protonation of histidine residues which occurs in this pH region.	Histidine	274-283	histidine-rich glycoprotein	Oryctolagus cuniculus	145-148
2437111-2	1987	Bovine NRP was identified as H-Ile-Ala-Arg-Arg-His-Pro-Tyr-Phe-Leu-OH, which is similar in structure to both neurotensin and angiotensin I. Canine and human NRP also had the above amino acid composition, whereas that obtained from rat plasma had valine substituted for isoleucine.	Histidine	47-50	optineurin	Homo sapiens	7-10
2437111-2	1987	Bovine NRP was identified as H-Ile-Ala-Arg-Arg-His-Pro-Tyr-Phe-Leu-OH, which is similar in structure to both neurotensin and angiotensin I. Canine and human NRP also had the above amino acid composition, whereas that obtained from rat plasma had valine substituted for isoleucine.	Histidine	47-50	optineurin	Homo sapiens	157-160
3657775-6	1987	The following values of kinetic parameters for the modification of pyruvate dehydrogenase component by diethylpyrocarbonate were obtained (pH 6.0; 20 degrees C): k1 = 6400 +/- 400 M-1 min-1 (the microscopic rate constant for the modification of histidine residue in the intact dimer), k2 = 890 +/- 200 M-1 min-1 (the rate constant for the modification of histidine residue in the intact subunit in the dimer which contains one modified subunit) and kt = 0.9 +/- 0.2 min-1 (the rate constant for conformational transition of the dimer induced by modification of histidine residue in one of the subunits in the dimeric molecule).	Histidine	245-254	CD59 molecule (CD59 blood group)	Homo sapiens	306-311
3657775-6	1987	The following values of kinetic parameters for the modification of pyruvate dehydrogenase component by diethylpyrocarbonate were obtained (pH 6.0; 20 degrees C): k1 = 6400 +/- 400 M-1 min-1 (the microscopic rate constant for the modification of histidine residue in the intact dimer), k2 = 890 +/- 200 M-1 min-1 (the rate constant for the modification of histidine residue in the intact subunit in the dimer which contains one modified subunit) and kt = 0.9 +/- 0.2 min-1 (the rate constant for conformational transition of the dimer induced by modification of histidine residue in one of the subunits in the dimeric molecule).	Histidine	245-254	CD59 molecule (CD59 blood group)	Homo sapiens	306-311
3657775-6	1987	The following values of kinetic parameters for the modification of pyruvate dehydrogenase component by diethylpyrocarbonate were obtained (pH 6.0; 20 degrees C): k1 = 6400 +/- 400 M-1 min-1 (the microscopic rate constant for the modification of histidine residue in the intact dimer), k2 = 890 +/- 200 M-1 min-1 (the rate constant for the modification of histidine residue in the intact subunit in the dimer which contains one modified subunit) and kt = 0.9 +/- 0.2 min-1 (the rate constant for conformational transition of the dimer induced by modification of histidine residue in one of the subunits in the dimeric molecule).	Histidine	355-364	CD59 molecule (CD59 blood group)	Homo sapiens	184-189
3657775-6	1987	The following values of kinetic parameters for the modification of pyruvate dehydrogenase component by diethylpyrocarbonate were obtained (pH 6.0; 20 degrees C): k1 = 6400 +/- 400 M-1 min-1 (the microscopic rate constant for the modification of histidine residue in the intact dimer), k2 = 890 +/- 200 M-1 min-1 (the rate constant for the modification of histidine residue in the intact subunit in the dimer which contains one modified subunit) and kt = 0.9 +/- 0.2 min-1 (the rate constant for conformational transition of the dimer induced by modification of histidine residue in one of the subunits in the dimeric molecule).	Histidine	355-364	CD59 molecule (CD59 blood group)	Homo sapiens	306-311
3657775-6	1987	The following values of kinetic parameters for the modification of pyruvate dehydrogenase component by diethylpyrocarbonate were obtained (pH 6.0; 20 degrees C): k1 = 6400 +/- 400 M-1 min-1 (the microscopic rate constant for the modification of histidine residue in the intact dimer), k2 = 890 +/- 200 M-1 min-1 (the rate constant for the modification of histidine residue in the intact subunit in the dimer which contains one modified subunit) and kt = 0.9 +/- 0.2 min-1 (the rate constant for conformational transition of the dimer induced by modification of histidine residue in one of the subunits in the dimeric molecule).	Histidine	355-364	CD59 molecule (CD59 blood group)	Homo sapiens	306-311
3657775-6	1987	The following values of kinetic parameters for the modification of pyruvate dehydrogenase component by diethylpyrocarbonate were obtained (pH 6.0; 20 degrees C): k1 = 6400 +/- 400 M-1 min-1 (the microscopic rate constant for the modification of histidine residue in the intact dimer), k2 = 890 +/- 200 M-1 min-1 (the rate constant for the modification of histidine residue in the intact subunit in the dimer which contains one modified subunit) and kt = 0.9 +/- 0.2 min-1 (the rate constant for conformational transition of the dimer induced by modification of histidine residue in one of the subunits in the dimeric molecule).	Histidine	355-364	CD59 molecule (CD59 blood group)	Homo sapiens	184-189
3657775-6	1987	The following values of kinetic parameters for the modification of pyruvate dehydrogenase component by diethylpyrocarbonate were obtained (pH 6.0; 20 degrees C): k1 = 6400 +/- 400 M-1 min-1 (the microscopic rate constant for the modification of histidine residue in the intact dimer), k2 = 890 +/- 200 M-1 min-1 (the rate constant for the modification of histidine residue in the intact subunit in the dimer which contains one modified subunit) and kt = 0.9 +/- 0.2 min-1 (the rate constant for conformational transition of the dimer induced by modification of histidine residue in one of the subunits in the dimeric molecule).	Histidine	355-364	CD59 molecule (CD59 blood group)	Homo sapiens	306-311
3657775-6	1987	The following values of kinetic parameters for the modification of pyruvate dehydrogenase component by diethylpyrocarbonate were obtained (pH 6.0; 20 degrees C): k1 = 6400 +/- 400 M-1 min-1 (the microscopic rate constant for the modification of histidine residue in the intact dimer), k2 = 890 +/- 200 M-1 min-1 (the rate constant for the modification of histidine residue in the intact subunit in the dimer which contains one modified subunit) and kt = 0.9 +/- 0.2 min-1 (the rate constant for conformational transition of the dimer induced by modification of histidine residue in one of the subunits in the dimeric molecule).	Histidine	355-364	CD59 molecule (CD59 blood group)	Homo sapiens	306-311
2438566-7	1987	After destroying 60% of the histidine residues in MBP by photooxidation and passing 125I-labeled photooxidized MBP over Sepharose columns containing immobilized protein, the second phase in binding was decreased significantly with immobilized cytochrome c, lysozyme, and MBP and to a smaller extent with ovalbumin.	Histidine	28-37	myelin basic protein	Bos taurus	50-53
2438566-8	1987	These results are consistent with the involvement of deprotonated histidine residues in the MBP-protein associations.	Histidine	66-75	myelin basic protein	Bos taurus	92-95
3567176-5	1987	Human antithrombin III has five histidine residues, bovine has six, and porcine has five.	Histidine	32-41	serpin family C member 1	Bos taurus	6-22
3103690-4	1987	We now confirm the involvement of serine and histidine in catalysing the phospholipase A2 action of lecithin-cholesterol acyltransferase by demonstrating the inhibition of this activity by phenylboronic acid (Ki = 1.23 mM) and m-aminophenylboronic acid (Ki = 2.32 mM), inhibitors of known serine/histidine hydrolases.	Histidine	45-54	phospholipase A2 group IB	Homo sapiens	73-89
3470784-9	1987	Sequence analysis of lambda MD41, however, revealed a single nucleotide substitution in the codon for residue 10 of proinsulin (CAC----GAC) that predicts the exchange of aspartic acid for histidine in the insulin B chain region.	Histidine	188-197	insulin	Homo sapiens	116-126
3470784-9	1987	Sequence analysis of lambda MD41, however, revealed a single nucleotide substitution in the codon for residue 10 of proinsulin (CAC----GAC) that predicts the exchange of aspartic acid for histidine in the insulin B chain region.	Histidine	188-197	insulin	Homo sapiens	119-126
2485065-3	1987	The minimal length for an effective substrate has been characterised as an octapeptide sequence derived from the amino terminal portion of angiotensinogen (residues 6----13): His-Pro-Phe-His-Leu-Val-Ile-His (Leu-Val is the scissile bond).	Histidine	187-190	angiotensinogen	Homo sapiens	139-154
3106550-6	1987	BALB/c apoA-II contains one residue each of histidine and arginine, neither of which are found in the human A-II protein.	Histidine	44-53	NLR family pyrin domain containing 3	Homo sapiens	10-14
2485065-3	1987	The minimal length for an effective substrate has been characterised as an octapeptide sequence derived from the amino terminal portion of angiotensinogen (residues 6----13): His-Pro-Phe-His-Leu-Val-Ile-His (Leu-Val is the scissile bond).	Histidine	175-178	angiotensinogen	Homo sapiens	139-154
3552036-7	1987	The faster step is first order in PAR and first order in insulin-bound Zn2+ (k congruent to 3 X 10(3) M-1 s-1) and involves the formation of an intermediate in which PAR is coordinated to insulin-bound zinc at the His-B10 site.	Histidine	214-217	insulin	Homo sapiens	57-64
3552036-7	1987	The faster step is first order in PAR and first order in insulin-bound Zn2+ (k congruent to 3 X 10(3) M-1 s-1) and involves the formation of an intermediate in which PAR is coordinated to insulin-bound zinc at the His-B10 site.	Histidine	214-217	insulin	Homo sapiens	188-195
3548423-1	1987	The human vasoactive intestinal polypeptide (VIP) precursor contains a sequence, a peptide with an N-terminal histidine and C-terminal methionine (PHM), which is 93% homologous to the porcine intestinal peptide, (PHI) a peptide having N-terminal histidine and C-terminal isoleucine amide, suggesting that PHI could be a product of the porcine VIP precursor.	Histidine	110-119	vasoactive intestinal peptide	Homo sapiens	10-43
3548423-1	1987	The human vasoactive intestinal polypeptide (VIP) precursor contains a sequence, a peptide with an N-terminal histidine and C-terminal methionine (PHM), which is 93% homologous to the porcine intestinal peptide, (PHI) a peptide having N-terminal histidine and C-terminal isoleucine amide, suggesting that PHI could be a product of the porcine VIP precursor.	Histidine	110-119	vasoactive intestinal peptide	Homo sapiens	45-48
3548423-1	1987	The human vasoactive intestinal polypeptide (VIP) precursor contains a sequence, a peptide with an N-terminal histidine and C-terminal methionine (PHM), which is 93% homologous to the porcine intestinal peptide, (PHI) a peptide having N-terminal histidine and C-terminal isoleucine amide, suggesting that PHI could be a product of the porcine VIP precursor.	Histidine	246-255	vasoactive intestinal peptide	Homo sapiens	10-43
3548423-1	1987	The human vasoactive intestinal polypeptide (VIP) precursor contains a sequence, a peptide with an N-terminal histidine and C-terminal methionine (PHM), which is 93% homologous to the porcine intestinal peptide, (PHI) a peptide having N-terminal histidine and C-terminal isoleucine amide, suggesting that PHI could be a product of the porcine VIP precursor.	Histidine	246-255	vasoactive intestinal peptide	Homo sapiens	45-48
2485065-3	1987	The minimal length for an effective substrate has been characterised as an octapeptide sequence derived from the amino terminal portion of angiotensinogen (residues 6----13): His-Pro-Phe-His-Leu-Val-Ile-His (Leu-Val is the scissile bond).	Histidine	187-190	angiotensinogen	Homo sapiens	139-154
2485065-5	1987	The homologous fungal aspartic proteinase, endothiapepsin, has been cocrystallised with human renin inhibitors of the type His-Pro-Phe-His-Leu-R-Val-Ile-His, where R indicates a reduced carbonyl analogue of the scissile peptide bond.	Histidine	123-126	renin	Homo sapiens	94-99
2485065-5	1987	The homologous fungal aspartic proteinase, endothiapepsin, has been cocrystallised with human renin inhibitors of the type His-Pro-Phe-His-Leu-R-Val-Ile-His, where R indicates a reduced carbonyl analogue of the scissile peptide bond.	Histidine	135-138	renin	Homo sapiens	94-99
2485065-5	1987	The homologous fungal aspartic proteinase, endothiapepsin, has been cocrystallised with human renin inhibitors of the type His-Pro-Phe-His-Leu-R-Val-Ile-His, where R indicates a reduced carbonyl analogue of the scissile peptide bond.	Histidine	135-138	renin	Homo sapiens	94-99
3016716-1	1986	We have constructed synthetic peptides modeled on the sequences of (i) Arg-Gly-Asp, present in fibrinogen, fibronectin, and von Willebrand factor, and of (ii) the fibrinogen gamma chain (gamma 400-411) His-His-Leu-Gly-Gly-Ala-Lys-Gln-Ala-Gly-Asp-Val.	Histidine	202-205	fibrinogen gamma chain	Homo sapiens	163-200
3791584-7	1986	Adenosine deaminase, an enzyme that deaminates adenosine to inosine and is limited to the extracellular space, significantly attenuated (61%) the atria-to-His-bundle interval prolongation caused by hypoxia.	Histidine	155-158	adenosine deaminase	Cavia porcellus	0-19
3020546-5	1986	Peptide NH2-terminal histidine, COOH-terminal isoleucine, which has greater than 50% sequence homology of VIP, stimulated the synthesis of both proteins at approximately 50% of VIP effectiveness.	Histidine	21-30	vasoactive intestinal peptide	Rattus norvegicus	106-109
3020546-5	1986	Peptide NH2-terminal histidine, COOH-terminal isoleucine, which has greater than 50% sequence homology of VIP, stimulated the synthesis of both proteins at approximately 50% of VIP effectiveness.	Histidine	21-30	vasoactive intestinal peptide	Rattus norvegicus	177-180
3447169-1	1987	A few years ago we reported that histidine (HC3) 146 beta plays a major role in the pH-dependent properties of the R-state of human hemoglobin, accounting for close to 50% of the R-state Bohr effect.	Histidine	33-42	CYCS pseudogene 24	Homo sapiens	44-47
3482484-11	1987	At these molar ratios of 0, 2 and 4, the decrease in p50 is 0.017 kPa/%Hi, 0.023 kPa/%Hi and 0.028 kPa/%Hi, respectively.	Histidine	71-73	nuclear factor kappa B subunit 1	Homo sapiens	53-56
3482484-11	1987	At these molar ratios of 0, 2 and 4, the decrease in p50 is 0.017 kPa/%Hi, 0.023 kPa/%Hi and 0.028 kPa/%Hi, respectively.	Histidine	86-88	nuclear factor kappa B subunit 1	Homo sapiens	53-56
3482484-11	1987	At these molar ratios of 0, 2 and 4, the decrease in p50 is 0.017 kPa/%Hi, 0.023 kPa/%Hi and 0.028 kPa/%Hi, respectively.	Histidine	86-88	nuclear factor kappa B subunit 1	Homo sapiens	53-56
2946663-3	1986	Spontaneous mutation of E. coli (his----his+) required both the protease and recombinase activities.	Histidine	33-39	recombinase	Escherichia coli	77-88
2946663-3	1986	Spontaneous mutation of E. coli (his----his+) required both the protease and recombinase activities.	Histidine	33-36	recombinase	Escherichia coli	77-88
3759950-0	1986	The influence of uncoordinated histidines on iron release from transferrin.	Histidine	31-41	transferrin	Homo sapiens	63-74
3759950-2	1986	Histidine residues that influence the chelate-mediated removal of iron from transferrin have been investigated.	Histidine	0-9	transferrin	Homo sapiens	76-87
3759950-3	1986	Diferric human serum transferrin was chemically modified to various extents using ethoxyformic anhydride, a reagent for histidines.	Histidine	120-130	transferrin	Homo sapiens	21-32
3759950-5	1986	There are 18 histidine residues in transferrin.	Histidine	13-22	transferrin	Homo sapiens	35-46
3533067-0	1986	Presence of a histidine at the active site of the neutral endopeptidase-24.11.	Histidine	14-23	membrane metalloendopeptidase	Homo sapiens	50-77
3016716-10	1986	The peptide Tyr-His-His-Lys-Arg-Lys-Arg-Lys-Gln-Arg-Gly-Asp-Val was labeled with 125I to quantitate its binding to thrombin-stimulated platelets; at saturation, 59,990 molecules were bound per cell (Kd = 3.8 X 10(-7) M).	Histidine	16-19	coagulation factor II, thrombin	Homo sapiens	115-123
3016716-10	1986	The peptide Tyr-His-His-Lys-Arg-Lys-Arg-Lys-Gln-Arg-Gly-Asp-Val was labeled with 125I to quantitate its binding to thrombin-stimulated platelets; at saturation, 59,990 molecules were bound per cell (Kd = 3.8 X 10(-7) M).	Histidine	20-23	coagulation factor II, thrombin	Homo sapiens	115-123
3016716-1	1986	We have constructed synthetic peptides modeled on the sequences of (i) Arg-Gly-Asp, present in fibrinogen, fibronectin, and von Willebrand factor, and of (ii) the fibrinogen gamma chain (gamma 400-411) His-His-Leu-Gly-Gly-Ala-Lys-Gln-Ala-Gly-Asp-Val.	Histidine	206-209	fibrinogen gamma chain	Homo sapiens	163-200
3518635-2	1986	The molecule was found to differ from human insulin at four positions, A8 (Ala), A10 (Val), A18 (His), and B30 (Ala).	Histidine	97-100	insulin	Homo sapiens	44-51
3741422-1	1986	Angiotensin II, the potent hypertensive octapeptide, can be generated by a sequential cleavage of the carboxyl-terminal leucine and histidine from angiotensin I by a human renal extract.	Histidine	132-141	angiotensinogen	Homo sapiens	0-14
3741422-1	1986	Angiotensin II, the potent hypertensive octapeptide, can be generated by a sequential cleavage of the carboxyl-terminal leucine and histidine from angiotensin I by a human renal extract.	Histidine	132-141	angiotensinogen	Homo sapiens	147-160
3543358-5	1986	The analogues having a Phe residue in place of Val1 (X) and His or amino acid with an aliphatic side chain such as norleucine or norvaline in the Y position showed the highest inhibition of human plasma renin activity with IC50 values of about 10(-8)M. Esterification or amidification of the carboxyl group of the C-terminal statine did not change the inhibitory potency.	Histidine	60-63	renin	Homo sapiens	203-208
2942107-4	1986	Considering the role of histidine protonation in PFK allosteric control, the capacity for regulatory kinetics seen at pH 8 in the Artemia enzyme could be explained in part by upward shifts in pKa values of ionizable residues.	Histidine	24-33	ATP-dependent 6-phosphofructokinase, muscle type	Oryctolagus cuniculus	49-52
3700425-5	1986	Modification of 1 serine residue with phenylmethanesulfonyl fluoride or 1 histidine residue with diethyl pyrocarbonate inhibited cholesteryl ester formation and phospholipase A2 activity.	Histidine	74-83	phospholipase A2 group IB	Homo sapiens	161-177
3518635-3	1986	A comparison with other known insulin structures suggests that cat insulin has an uncommon property: it appears to be the only insulin found so far with His at position A18.	Histidine	153-156	insulin	Homo sapiens	30-37
3518635-3	1986	A comparison with other known insulin structures suggests that cat insulin has an uncommon property: it appears to be the only insulin found so far with His at position A18.	Histidine	153-156	insulin	Homo sapiens	67-74
3518635-3	1986	A comparison with other known insulin structures suggests that cat insulin has an uncommon property: it appears to be the only insulin found so far with His at position A18.	Histidine	153-156	insulin	Homo sapiens	67-74
3001042-2	1986	At millimolar concentrations, reagent grade NaF inhibited glucose-6-P hydrolysis and protected the enzyme against inactivation induced by heat in the presence of 0.025% (w/v) Triton X-100 or by reaction of the catalytic site with the histidine-specific reagent, diethyl pyrocarbonate.	Histidine	234-243	C-X-C motif chemokine ligand 8	Homo sapiens	44-47
3719856-2	1986	The addition of saturating amounts of the substrate benzphetamine to this haemoprotein shifted the spin equilibrium to the high spin form, resulting in a doubling of the spin equilibrium constant from 0.220 to 0.539 at 20 degrees C. The histidine residues of this low spin, substrate-free cytochrome P-450 were modified in a time- and concentration-dependent manner with diethylpyrocarbonate, and progressive histidine modification resulted in a decrease of both the affinity and extent of substrate interaction with the haemoprotein.	Histidine	237-246	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	289-305
3719856-4	1986	These results indicate that a histidine residue(s) is involved in the binding of substrate to cytochrome P-450 and hence interferes with the substrate-bound spin equilibrium.	Histidine	30-39	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	94-110
2420636-0	1986	Hypotensive activity of histidine-containing analogues of C-terminal hexapeptide of substance P.	Histidine	24-33	tachykinin precursor 1	Homo sapiens	84-95
2869789-5	1986	Drug-induced perturbations in the spectrum of calmodulin indicate that the binding site is in the C-terminal half of the protein, and involves a hydrophobic area containing His-107, Met-144, Met-145 and possibly Phe-89, Phe-141, and calcium binding site III.	Histidine	173-176	calmodulin 1	Homo sapiens	46-56
3754463-3	1986	A fragment of MLCK containing the phosphorylation site was shown to have the amino acid sequence Ala-Arg-Arg-Lys-Trp-Gln-Lys-Thr-Gly-His-Ala-Val-Arg-Ala-Ile-Gly-Arg-Leu- Ser-Ser.	Histidine	133-136	myosin light chain kinase, smooth muscle	Oryctolagus cuniculus	14-18
3081342-6	1986	Both major forms have the same amino-terminal sequence, which includes that of ovine angiotensin I: Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu.	Histidine	120-123	angiotensinogen	Homo sapiens	85-98
3081342-6	1986	Both major forms have the same amino-terminal sequence, which includes that of ovine angiotensin I: Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu.	Histidine	132-135	angiotensinogen	Homo sapiens	85-98
3719856-0	1986	Chemical modification of the histidine residues of purified hepatic cytochrome P-450: influence on substrate binding and the haemoprotein spin state.	Histidine	29-38	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	68-84
2869783-0	1986	Chemical modification of essential carboxyl group and histidine residue in the plasma-membrane 5"-nucleotidase.	Histidine	54-63	5'-nucleotidase	Bos taurus	95-110
3456154-0	1986	Distinctive role of histidine-16 of the B beta chain of fibrinogen in the end-to-end association of fibrin.	Histidine	20-29	fibrinogen beta chain	Homo sapiens	56-66
3456154-8	1986	This shows that histidine-16 of the B beta chain of fibrinogen is essential for site A but may not be essential for site B.	Histidine	16-25	fibrinogen beta chain	Homo sapiens	52-62
3456154-9	1986	It is of interest that histidine-16 of the B beta chain, which is only one residue away from the thrombin-susceptible bond, makes a part of the site A for the end-to-end association created by the release of fibrinopeptide A.	Histidine	23-32	coagulation factor II, thrombin	Homo sapiens	97-105
2419146-6	1986	The contractile potency of NKA and NKB remained nearly complete after removal of N-terminal tripeptide portions, i.e., His-Lys-Thr and Asp-Met-His from the native peptides, respectively.	Histidine	119-122	tachykinin-3	Cavia porcellus	35-38
2419146-6	1986	The contractile potency of NKA and NKB remained nearly complete after removal of N-terminal tripeptide portions, i.e., His-Lys-Thr and Asp-Met-His from the native peptides, respectively.	Histidine	143-146	tachykinin-3	Cavia porcellus	35-38
3003303-6	1985	The minimal substrate for renin has the sequence: His-Pro-Phe-His-Leu-Val-Tyr.	Histidine	50-53	renin	Homo sapiens	26-31
3936495-2	1985	We investigated the binding of HMWK to factor XIa utilizing two active site directed fluorescent probes: nitrobenzoxadiazole aminopentyl methylphosphonofluoridate for serine and dansyl-glu-gly-arg-chloromethyl ketone for histidine.	Histidine	221-230	kininogen 1	Homo sapiens	31-35
3917039-2	1985	On deoxygenation, the conformation of this region changes substantially, allowing complexation only through the ND1 nitrogen atom of His-113, a much less favorable interaction.	Histidine	133-136	mitochondrially encoded NADH dehydrogenase 1	Homo sapiens	112-115
3748844-4	1986	Six exons were thus far discovered; among them two short exons, one encoding VIP and the second encoding PHM-27 (a peptide having a N-terminal histidine and C-terminal methionine amide, closely related in sequence and activity to VIP).	Histidine	143-152	vasoactive intestinal peptide	Homo sapiens	105-111
4086164-2	1985	The possible existence of intramolecular interactions involving the tyrosine and histidine residues in angiotensin II has been investigated by measuring the reactivities of the functional groups in the molecule.	Histidine	81-90	angiotensinogen	Homo sapiens	103-117
3003303-6	1985	The minimal substrate for renin has the sequence: His-Pro-Phe-His-Leu-Val-Tyr.	Histidine	62-65	renin	Homo sapiens	26-31
4084500-1	1985	The heme binding sites of rabbit histidine-rich glycoprotein (HRG), 94 kDa, were studied with rose bengal (RB), a fluorescein derivative that associates with histidine residues.	Histidine	33-42	histidine-rich glycoprotein	Oryctolagus cuniculus	62-65
3911093-4	1985	Cathepsin B hydrolyzed angiotensin I via a dipeptidyl carboxypeptidase mechanism removing His-Leu to form angiotensin II, and it degraded angiotensin II as an endopeptidase at the Val3-Tyr4 bond.	Histidine	90-93	angiotensinogen	Homo sapiens	23-36
4055729-1	1985	The flavoenzymes dimethylglycine dehydrogenase (EC 1.5.99.2) and sarcosine dehydrogenase (EC 1.5.99.1) contain covalently bound FAD linked via the 8 alpha-position of the isoalloxazine ring to the imidazole N(3) of a histidine residue (Cook, R. J., Misono, K. S., and Wagner, C. (1984) J. Biol.	Histidine	217-226	sarcosine dehydrogenase	Rattus norvegicus	65-88
4055729-6	1985	The sequence determined for the flavin-peptide from sarcosine dehydrogenase contained 14 amino acid residues Leu-Thr-Ser-Gly-Thr-Thr-Trp-His(flavin)-Thr-Ala-Gly-Leu-Gly-Arg.	Histidine	137-140	sarcosine dehydrogenase	Rattus norvegicus	52-75
2865955-3	1985	The participation of "thyroliberinase", a metalloenzyme which cleaves TRH at the pyroglutamyl-His bond was implied.	Histidine	94-97	thyrotropin releasing hormone degrading enzyme	Homo sapiens	21-37
3840166-5	1985	The affinity of the hormone-bound estrogen receptor for DNA in Tris buffer at pH 7.4 in 0.2 M KCl is 10-fold greater than at pH 8.0, suggesting that ionic bonding between the receptor and DNA may involve histidine residues of the receptor.	Histidine	204-213	estrogen receptor 1	Homo sapiens	34-51
4084500-6	1985	The two preferred RB binding sites of HRG are located on the 15-kDa histidine-poor peptide and the lower affinity "class" of sites on the 35-kDa histidine-rich peptide.	Histidine	68-77	histidine-rich glycoprotein	Oryctolagus cuniculus	38-41
4074702-8	1985	The 1H NMR spectrum of isocitrate dehydrogenase at pH 7.5 has three narrow peaks between delta 7.85 and 7.69 that shift with changes in pH and hence arise from C-4 protons of histidines.	Histidine	175-185	complement C4-A	Sus scrofa	160-163
3001041-3	1985	In the amino acid compositions of Ch1 and Ch2, two residues of histidine were contained in Ch2, but none in Ch1, and one residue of cysteine was contained in Ch1, but none in Ch2.	Histidine	63-72	SUN domain containing ossification factor	Gallus gallus	34-37
3840230-9	1985	Each of these regions contains the presumed active site sequence Trp-Cys-Gly-His-Cys-Lys, suggesting that PDI, similar in action to thioredoxin, catalyses disulphide bond interchange via an internal disulphide-sulphydryl interchange.	Histidine	77-80	thioredoxin 1	Rattus norvegicus	132-143
4033346-6	1985	Dog VIP was found to have the following sequence: His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala -Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn.	Histidine	50-53	vasoactive intestinal peptide	Canis lupus familiaris	4-7
2991265-13	1985	His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2 (substance K) and bombesin are degraded by striatal but not lung ACE.	Histidine	0-3	angiotensin I converting enzyme	Rattus norvegicus	109-112
4030766-11	1985	Alkylation of an essential histidine residue of DNase II occurs on incubation of the enzyme with [2-14C] ICH2COOH (Oshima, R. G., and Price, P. A.	Histidine	27-36	caspase 4	Homo sapiens	105-109
3996602-2	1985	Five of the 12 tyrosine, tryptophan and histidine residues of human lysozyme are found to be accessible to flavin dye in solution.	Histidine	40-49	lysozyme	Homo sapiens	68-76
2863287-2	1985	We found that histidine, glutamate, and lysine increase vasopressin-stimulated water flow by 75%, 60%, and 43%, respectively.	Histidine	14-23	arginine vasopressin	Homo sapiens	56-67
2863287-14	1985	Methylation of histidine on the imidazole ring completely abolished its effectiveness in increasing vasopressin-stimulated water flow.	Histidine	15-24	arginine vasopressin	Homo sapiens	100-111
2863287-15	1985	In contrast, methylation of histidine at the side chain increased vasopressin action similar to that found for histidine.	Histidine	28-37	arginine vasopressin	Homo sapiens	66-77
2863287-15	1985	In contrast, methylation of histidine at the side chain increased vasopressin action similar to that found for histidine.	Histidine	111-120	arginine vasopressin	Homo sapiens	66-77
2991923-2	1985	Ty917 prevents HIS4 transcription, thus rendering the cell histidine requiring.	Histidine	59-68	trifunctional histidinol dehydrogenase/phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase	Saccharomyces cerevisiae S288C	15-19
2992508-1	1985	The effects of complex formation with flavodoxin on the proton NMR spectrum of cytochrome c are to change the resonance frequencies and to increase the bandwidths of most of the low and high field heme, Met-80, and His-18 protons.	Histidine	215-218	cytochrome c, somatic	Homo sapiens	79-91
3839670-3	1985	The structurally homologous peptides, Peptide Histidine Isoleucine (PHI) and secretin, were, respectively, 72-fold and 413-fold less potent than VIP in displacing bound [125 I]VIP, whereas the unrelated peptides, neurotensin, eledoisin, bombesin and metenkephalin, were without effect on the binding.	Histidine	46-55	vasoactive intestinal peptide	Homo sapiens	176-179
2859986-4	1985	The stimulatory actions of GH-releasing factor (GRF) and porcine heptacosapeptide with amino-terminal histidine and carboxy-terminal isoleucine amide (PHI) were mediated by high affinity VIP receptors because their effects were not additive with that of 10 nM VIP.	Histidine	102-111	vasoactive intestinal polypeptide	Mus musculus	187-190
3887901-6	1985	The minimal substrate for renin has the sequence: His-Pro-Phe-His-Leu-Leu-Val-Tyr.	Histidine	50-53	renin	Homo sapiens	26-31
3886645-8	1985	Statistical analysis of residual enzyme activity and extent of modification indicates that among 7 histidyl residues modified per molecule, there is 1 essential histidine (not in the active site) involved in the potential fibrinogen-clotting activity of prothrombin.	Histidine	161-170	fibrinogen beta chain	Homo sapiens	222-232
3886645-8	1985	Statistical analysis of residual enzyme activity and extent of modification indicates that among 7 histidyl residues modified per molecule, there is 1 essential histidine (not in the active site) involved in the potential fibrinogen-clotting activity of prothrombin.	Histidine	161-170	coagulation factor II, thrombin	Homo sapiens	254-265
2987932-1	1985	The human precursor gene for vasoactive intestinal peptide (VIP) and PHM-27, a peptide that has an NH2-terminal histidine and COOH-terminal methionine amide and is closely related in sequence and activity to VIP, was detected with synthetic oligodeoxynucleotide probes.	Histidine	112-121	vasoactive intestinal peptide	Homo sapiens	29-58
2987932-1	1985	The human precursor gene for vasoactive intestinal peptide (VIP) and PHM-27, a peptide that has an NH2-terminal histidine and COOH-terminal methionine amide and is closely related in sequence and activity to VIP, was detected with synthetic oligodeoxynucleotide probes.	Histidine	112-121	vasoactive intestinal peptide	Homo sapiens	60-63
2987932-1	1985	The human precursor gene for vasoactive intestinal peptide (VIP) and PHM-27, a peptide that has an NH2-terminal histidine and COOH-terminal methionine amide and is closely related in sequence and activity to VIP, was detected with synthetic oligodeoxynucleotide probes.	Histidine	112-121	vasoactive intestinal peptide	Homo sapiens	69-75
3886645-0	1985	Modification of histidines in human prothrombin.	Histidine	16-26	coagulation factor II, thrombin	Homo sapiens	36-47
3887901-6	1985	The minimal substrate for renin has the sequence: His-Pro-Phe-His-Leu-Leu-Val-Tyr.	Histidine	62-65	renin	Homo sapiens	26-31
2984118-4	1985	The Km and Vmax are reported for rat serum ACE (Hip-His-Leu) and dipeptidase (His-Leu) in borate buffer and phosphate buffer.	Histidine	52-55	angiotensin I converting enzyme	Rattus norvegicus	43-46
3916937-1	1985	Methylated lysine, arginine and histidine residues are found in a number of proteins (for example, histones, non-histone chromosomal proteins, ribosomal proteins, calmodulin, cytochrome C, etc.).	Histidine	32-41	cytochrome c, somatic	Homo sapiens	175-187
2984118-1	1985	The most sensitive nonradiometric routine assay for angiotensin-converting enzyme (ACE) activity uses fluorometry to detect His-Leu released from Hip-His-Leu.	Histidine	124-127	angiotensin I converting enzyme	Rattus norvegicus	52-81
2984118-1	1985	The most sensitive nonradiometric routine assay for angiotensin-converting enzyme (ACE) activity uses fluorometry to detect His-Leu released from Hip-His-Leu.	Histidine	124-127	angiotensin I converting enzyme	Rattus norvegicus	83-86
2984118-1	1985	The most sensitive nonradiometric routine assay for angiotensin-converting enzyme (ACE) activity uses fluorometry to detect His-Leu released from Hip-His-Leu.	Histidine	150-153	angiotensin I converting enzyme	Rattus norvegicus	52-81
2984118-1	1985	The most sensitive nonradiometric routine assay for angiotensin-converting enzyme (ACE) activity uses fluorometry to detect His-Leu released from Hip-His-Leu.	Histidine	150-153	angiotensin I converting enzyme	Rattus norvegicus	83-86
3994995-0	1985	Unusual chemical properties of N-terminal histidine residues of glucagon and vasoactive intestinal peptide.	Histidine	42-51	vasoactive intestinal peptide	Homo sapiens	77-106
3994995-6	1985	Similarly, in glucagon and vasoactive intestinal peptide (VIP), apparent pKa values of 7.60 +/- 0.04 and 7.88 +/- 0.18, respectively, were obtained for the alpha-amino of their N-terminal histidine, and pKa values of 7.43 +/- 0.09 and 7.59 +/- 0.18 were obtained for the imidazole function.	Histidine	188-197	vasoactive intestinal peptide	Homo sapiens	27-56
3994995-6	1985	Similarly, in glucagon and vasoactive intestinal peptide (VIP), apparent pKa values of 7.60 +/- 0.04 and 7.88 +/- 0.18, respectively, were obtained for the alpha-amino of their N-terminal histidine, and pKa values of 7.43 +/- 0.09 and 7.59 +/- 0.18 were obtained for the imidazole function.	Histidine	188-197	vasoactive intestinal peptide	Homo sapiens	58-61
2981610-5	1985	The destruction of cytochrome P-450 was a photodynamic process requiring oxygen since quenchers of singlet oxygen, including 2,5-dimethylfuran, histidine, and beta-carotene, each substantially diminished the reaction.	Histidine	144-153	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	19-35
2983326-5	1985	ACE also released the COOH-terminal tripeptide, Arg-Pro-Gly-NH2, and then sequentially the dipeptides Gly-Leu and Ser-Try, leaving less than Glu-His-Trp intact.	Histidine	145-148	angiotensin I converting enzyme	Homo sapiens	0-3
3913581-1	1985	The nerve growth factor dimer (beta NGF) can undergo two proteolytic modifications, one near the amino terminus where a unique histidine/methionine bond is cleaved and the other at the carboxy terminus releasing the terminal arginine residue.	Histidine	127-136	nerve growth factor	Homo sapiens	31-39
2939907-6	1985	The effect of histidine to increase vasopressin-stimulated water flow, however, depends on increased permeability of both the luminal membrane as well as the underlying structures.	Histidine	14-23	arginine vasopressin	Homo sapiens	36-47
3839772-0	1985	Hemoglobin Twin Peaks alpha 113 (GH1) Leu----His.	Histidine	45-48	growth hormone 1	Homo sapiens	33-36
4011849-5	1985	The three His residues of alpha-lactalbumin have different degrees of exposure and show two different kinetics of photooxidation whereas the His residue of lysozyme is photooxidized with a single kinetic.	Histidine	10-13	lactalbumin alpha	Homo sapiens	26-43
4011849-5	1985	The three His residues of alpha-lactalbumin have different degrees of exposure and show two different kinetics of photooxidation whereas the His residue of lysozyme is photooxidized with a single kinetic.	Histidine	141-144	lactalbumin alpha	Homo sapiens	26-43
6395896-9	1984	Trp-84 appears to be quenched in pig and rabbit GAPD, most likely by His-108.	Histidine	69-72	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	48-52
6395896-10	1984	In yeast GAPD, on the other hand, Trp-84 is not quenched, probably because His-108 is further removed.	Histidine	75-78	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	9-13
6490627-10	1984	Amino acid composition and N-terminal analysis suggested the sequence of the flavin-peptide of sarcosine dehydrogenase was His(flavin)-(Ala, Gly,Thr)-Leu.	Histidine	123-126	sarcosine dehydrogenase	Rattus norvegicus	95-118
6526885-1	1984	alpha-Melanotropin (alpha-MSH) is a linear tridecapeptide (Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2), that is primarily known for its ability to stimulate melanosome dispersion within integumental melanocytes (F. J. H. Tilders, D. F. Swaab and T. B. van Wimersma Greidanus (Editors), Frontiers of Hormone Research, Vol.	Histidine	82-85	proopiomelanocortin	Homo sapiens	26-29
6523446-10	1984	The ionization of this histidine residue and the accompanying conformational changes could explain the reduced catalytic efficiency and stability of alpha-thrombin at pH 6.	Histidine	23-32	coagulation factor II, thrombin	Homo sapiens	155-163
6504721-1	1984	The importance of the N-terminal His residue of VIP for stimulating adenylate cyclase was appreciated by estimating the intrinsic activity and EC50 of four VIP analogues on membranes from rat lung, liver, brain, anterior pituitary, and pancreas, and on human heart membranes.	Histidine	33-36	vasoactive intestinal peptide	Rattus norvegicus	48-51
6548446-2	1984	A novel form of the polypeptide termed PHI (peptide HI with N-terminal histidine and C-terminal isoleucine amide) has been isolated from bovine upper intestine.	Histidine	71-80	glucose-6-phosphate isomerase	Bos taurus	39-42
6496943-1	1984	The chemical shifts of the isoleucine and histidine protons of angiotensin I were assigned and the chemical shifts of the protons of the other amino acids in the peptide were confirmed at a field strength of 400 MHz.	Histidine	42-51	angiotensinogen	Homo sapiens	63-76
6385771-1	1984	A synthetic tetradecapeptide, H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH, which corresponds to the 13 amino terminal residues of human angiotensinogen plus a carboxy terminal serine to replace a suggested site of carbohydrate attachment, has been shown to be a good substrate for human kidney renin.	Histidine	52-55	angiotensinogen	Homo sapiens	153-168
6385771-0	1984	Renin cleavage of a human kidney renin substrate analogous to human angiotensinogen, H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH, that is human renin specific and is resistant to cathepsin D.	Histidine	107-110	renin	Homo sapiens	0-5
6385771-0	1984	Renin cleavage of a human kidney renin substrate analogous to human angiotensinogen, H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH, that is human renin specific and is resistant to cathepsin D.	Histidine	107-110	renin	Homo sapiens	33-38
6385771-1	1984	A synthetic tetradecapeptide, H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH, which corresponds to the 13 amino terminal residues of human angiotensinogen plus a carboxy terminal serine to replace a suggested site of carbohydrate attachment, has been shown to be a good substrate for human kidney renin.	Histidine	52-55	renin	Homo sapiens	311-316
6385771-0	1984	Renin cleavage of a human kidney renin substrate analogous to human angiotensinogen, H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH, that is human renin specific and is resistant to cathepsin D.	Histidine	107-110	angiotensinogen	Homo sapiens	68-83
6385771-0	1984	Renin cleavage of a human kidney renin substrate analogous to human angiotensinogen, H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH, that is human renin specific and is resistant to cathepsin D.	Histidine	107-110	renin	Homo sapiens	161-166
6385771-1	1984	A synthetic tetradecapeptide, H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH, which corresponds to the 13 amino terminal residues of human angiotensinogen plus a carboxy terminal serine to replace a suggested site of carbohydrate attachment, has been shown to be a good substrate for human kidney renin.	Histidine	64-67	angiotensinogen	Homo sapiens	153-168
6385771-0	1984	Renin cleavage of a human kidney renin substrate analogous to human angiotensinogen, H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH, that is human renin specific and is resistant to cathepsin D.	Histidine	119-122	renin	Homo sapiens	0-5
6385771-0	1984	Renin cleavage of a human kidney renin substrate analogous to human angiotensinogen, H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH, that is human renin specific and is resistant to cathepsin D.	Histidine	119-122	renin	Homo sapiens	33-38
6385771-1	1984	A synthetic tetradecapeptide, H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH, which corresponds to the 13 amino terminal residues of human angiotensinogen plus a carboxy terminal serine to replace a suggested site of carbohydrate attachment, has been shown to be a good substrate for human kidney renin.	Histidine	64-67	renin	Homo sapiens	311-316
6385771-0	1984	Renin cleavage of a human kidney renin substrate analogous to human angiotensinogen, H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH, that is human renin specific and is resistant to cathepsin D.	Histidine	119-122	angiotensinogen	Homo sapiens	68-83
6385771-1	1984	A synthetic tetradecapeptide, H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH, which corresponds to the 13 amino terminal residues of human angiotensinogen plus a carboxy terminal serine to replace a suggested site of carbohydrate attachment, has been shown to be a good substrate for human kidney renin.	Histidine	64-67	angiotensinogen	Homo sapiens	153-168
6385771-0	1984	Renin cleavage of a human kidney renin substrate analogous to human angiotensinogen, H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH, that is human renin specific and is resistant to cathepsin D.	Histidine	119-122	renin	Homo sapiens	161-166
6385771-0	1984	Renin cleavage of a human kidney renin substrate analogous to human angiotensinogen, H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH, that is human renin specific and is resistant to cathepsin D.	Histidine	119-122	renin	Homo sapiens	0-5
6385771-1	1984	A synthetic tetradecapeptide, H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH, which corresponds to the 13 amino terminal residues of human angiotensinogen plus a carboxy terminal serine to replace a suggested site of carbohydrate attachment, has been shown to be a good substrate for human kidney renin.	Histidine	64-67	renin	Homo sapiens	311-316
6385771-0	1984	Renin cleavage of a human kidney renin substrate analogous to human angiotensinogen, H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH, that is human renin specific and is resistant to cathepsin D.	Histidine	119-122	renin	Homo sapiens	33-38
6385771-0	1984	Renin cleavage of a human kidney renin substrate analogous to human angiotensinogen, H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH, that is human renin specific and is resistant to cathepsin D.	Histidine	119-122	angiotensinogen	Homo sapiens	68-83
6380499-2	1984	Calculations and comparison of low energy structures for these peptides give support to the existence of a beta-turn-like structure involving the His-Pro-Phe-His region of the renin substrate and of the competitive inhibitors containing that sequence.	Histidine	146-149	renin	Homo sapiens	176-181
6385771-0	1984	Renin cleavage of a human kidney renin substrate analogous to human angiotensinogen, H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH, that is human renin specific and is resistant to cathepsin D.	Histidine	119-122	renin	Homo sapiens	161-166
6380499-2	1984	Calculations and comparison of low energy structures for these peptides give support to the existence of a beta-turn-like structure involving the His-Pro-Phe-His region of the renin substrate and of the competitive inhibitors containing that sequence.	Histidine	158-161	renin	Homo sapiens	176-181
6099385-6	1984	The minimal substrate for renin has the sequence: His-Pro-Phe-His-Leu-Leu-Val-Tyr.	Histidine	50-53	renin	Homo sapiens	26-31
6743343-0	1984	NMR studies on angiotensin II: histidine and phenylalanine ring stacking and biological activity.	Histidine	31-40	angiotensinogen	Homo sapiens	15-29
6743343-3	1984	The chemical shifts for the histidine C2 and C4 protons in angiotensin II also indicate shielding, whereas these same protons in the antagonist [Sar1, Ile8]angiotensin II do not demonstrate this shielding influence.	Histidine	28-37	angiotensinogen	Homo sapiens	59-73
6743343-4	1984	These findings suggest a stacking interaction for the histidine and phenylalanine side-chains in angiotensin II which is important for activating angiotensin receptors.	Histidine	54-63	angiotensinogen	Homo sapiens	97-111
6429132-8	1984	The following unique NH2-terminal amino acid sequence of the purified PSF was obtained: NH2ALA -SER-Ile-Ser-X-X-Asp-Thr-His-Arg-Leu-Thr-Arg-.	Histidine	120-123	interleukin 3	Mus musculus	70-73
6095055-6	1984	Strains carrying a Ty912 delta at HIS4 are His- at 23 degrees C. Unlinked suppressors (SPT) lead to suppression of this His- phenotype and increase levels of the normal HIS4 transcript.	Histidine	43-46	trifunctional histidinol dehydrogenase/phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase	Saccharomyces cerevisiae S288C	34-38
6099385-6	1984	The minimal substrate for renin has the sequence: His-Pro-Phe-His-Leu-Leu-Val-Tyr.	Histidine	62-65	renin	Homo sapiens	26-31
6546731-1	1984	Peptide histidine isoleucine (PHI) is a newly discovered peptide from porcine intestine, which has sequence homologies with VIP, an established intestinal secretagogue.	Histidine	8-17	vasoactive intestinal peptide	Homo sapiens	124-127
6427779-5	1984	The full sequence of chicken GnRH-II has been determined to be: pGlu-His-Trp-Ser-His-Gly-Trp-Tyr-Pro-Gly-NH2.	Histidine	69-72	mitochondrial ribosomal protein S26	Gallus gallus	29-36
6427779-5	1984	The full sequence of chicken GnRH-II has been determined to be: pGlu-His-Trp-Ser-His-Gly-Trp-Tyr-Pro-Gly-NH2.	Histidine	81-84	mitochondrial ribosomal protein S26	Gallus gallus	29-36
6325445-2	1984	The histidine-selective reagent diethyl pyrocarbonate and dye-sensitized photooxidation have been used to study the functional role of histidines in cytochrome c peroxidase.	Histidine	4-13	cytochrome c, somatic	Homo sapiens	149-161
6325445-2	1984	The histidine-selective reagent diethyl pyrocarbonate and dye-sensitized photooxidation have been used to study the functional role of histidines in cytochrome c peroxidase.	Histidine	135-145	cytochrome c, somatic	Homo sapiens	149-161
6325445-3	1984	Of the 6 histidines in cytochrome c peroxidase, 5 are modified by diethyl pyrocarbonate at alkaline pH and 4 by photooxidation.	Histidine	9-19	cytochrome c, somatic	Homo sapiens	23-35
6325445-8	1984	In the presence of cytochrome c, no enzymic activity is lost by photooxidation and a single histidine, His 181, is protected from oxidative destruction.	Histidine	92-101	cytochrome c, somatic	Homo sapiens	19-31
6654875-9	1983	The interacting sites and modes were discussed with these and the pH titration curves of His-12, His-119, and Phe-120 of RNase A in the presence of a three-fold molar excess of ribonucleotides.	Histidine	89-92	ribonuclease pancreatic	Bos taurus	121-128
6696878-7	1984	The amino-terminal sequence contained the covalent structure of angiotensin I and was Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-X-Glu-Ser-Thr-Cys-Gl u-.	Histidine	106-109	angiotensinogen	Homo sapiens	64-77
6696878-7	1984	The amino-terminal sequence contained the covalent structure of angiotensin I and was Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-X-Glu-Ser-Thr-Cys-Gl u-.	Histidine	118-121	angiotensinogen	Homo sapiens	64-77
6335884-1	1984	L-Histidine (L-His) and human serum albumin (HSA) at physiological concentrations, like the exogenous ligands D-penicillamine (D-PEN) and EDTA, are shown to inhibit the uptake of physiological levels of Ni2+ by B-lymphoblasts of human origin, human erythrocytes and rabbit alveolar macrophages.	Histidine	0-5	albumin	Homo sapiens	30-43
6207512-10	1984	One of the ovine brain peptides with GH-releasing activity was partially characterized as His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr- Lys-Arg-Try-Asn-Lys-Glu-Met- Ala-Lys--which is similar to rat GRF and porcine VIP having His at the N-terminus.	Histidine	90-93	vasoactive intestinal peptide	Rattus norvegicus	209-212
6196232-6	1983	The minimal substrate for renin is an octapeptide segment of the protein substrate: His-Pro-Phe-His-Leu-Leu-Val-Tyr.	Histidine	84-87	renin	Homo sapiens	26-31
6196232-6	1983	The minimal substrate for renin is an octapeptide segment of the protein substrate: His-Pro-Phe-His-Leu-Leu-Val-Tyr.	Histidine	96-99	renin	Homo sapiens	26-31
6418650-9	1983	The minimal substrate for renin is an octapeptide segment of the protein substrate: His-Pro-Phe-His-Leu-Leu-Val-Tyr.	Histidine	84-87	renin	Homo sapiens	26-31
6418650-9	1983	The minimal substrate for renin is an octapeptide segment of the protein substrate: His-Pro-Phe-His-Leu-Leu-Val-Tyr.	Histidine	96-99	renin	Homo sapiens	26-31
6373642-2	1984	Human [10-asparagine-B] insulin ([ Asn10 -B] insulin), an analogue which differs from the parent molecule in that the histidine residue at position 10 of the B chain (B10) is replaced by asparagine, has been synthesized and isolated in purified form.	Histidine	118-127	insulin	Homo sapiens	24-31
6421816-11	1984	In this variant, histidine was found at residue 3 in the apo-A-I sequence, rather than the usual proline.	Histidine	17-26	apolipoprotein A1	Homo sapiens	57-64
6320014-3	1984	Tonin can produce directly the vasoactive peptide angiotensin II, from angiotensin I, angiotensinogen and the synthetic tetradecapeptide substrate of renin by cleavage of a Phe-His bond.	Histidine	177-180	angiotensinogen	Rattus norvegicus	50-64
6142832-4	1984	The data obtained also attest to a possible involvement of the imidazole group of histidine in the realization of the myotropic effect of bradykinin.	Histidine	82-91	kininogen 1	Homo sapiens	138-148
6315594-7	1983	These three El Tor biotype markers were found to be closely linked to each other and were located between the pyrA-201 and his-2 loci on the genetic map of V. cholerae.	Histidine	123-126	RAR related orphan receptor C	Homo sapiens	15-18
6654875-9	1983	The interacting sites and modes were discussed with these and the pH titration curves of His-12, His-119, and Phe-120 of RNase A in the presence of a three-fold molar excess of ribonucleotides.	Histidine	97-100	ribonuclease pancreatic	Bos taurus	121-128
6648427-5	1983	It is therefore concluded that fibrinogen Bern II undergoes substitution of arginine in position 16 of the A alpha-chain by histidine.	Histidine	124-133	fibrinogen beta chain	Homo sapiens	31-41
6422631-0	1983	[Enzymatic conversion of L-histidine to urocanic acid using immobilized histidase from the rat liver].	Histidine	25-36	histidine ammonia lyase	Rattus norvegicus	72-81
6422631-3	1983	The preparation of immobilized histidase might be used for enzymatic synthesis of urocanic acid from histidine.	Histidine	101-110	histidine ammonia lyase	Rattus norvegicus	31-40
6137484-3	1983	The first step in the proteolytic degradation of bacterial glutamine synthetase is a mixed function oxidation of one of the 16 histidine residues in the glutamine synthetase subunit (Levine, R.L.	Histidine	127-136	glutamate-ammonia ligase	Homo sapiens	59-79
6137484-3	1983	The first step in the proteolytic degradation of bacterial glutamine synthetase is a mixed function oxidation of one of the 16 histidine residues in the glutamine synthetase subunit (Levine, R.L.	Histidine	127-136	glutamate-ammonia ligase	Homo sapiens	153-173
6409108-4	1983	The amino-terminal sequence of proapoA-I isolated from human lymph revealed the presence of 6 additional amino acids, Arg-His-Phe-Trp-Gln-Gln, on the amino-terminal end of apoA-I consistent with the proapoA-I sequence determined by nucleic acid sequence analysis of cloned apoA-I.	Histidine	122-125	apolipoprotein A1	Homo sapiens	34-40
6615822-1	1983	The proton magnetic resonance spectrum at 300 MHz of the histidine residues in a semisynthetic derivative of bovine pancreatic ribonuclease (RNase A) has been determined.	Histidine	57-66	ribonuclease pancreatic	Bos taurus	141-148
6615416-4	1983	The imidazole C-2-H resonances of the histidine residues (at positions 18, 21 and 151 in the somatotropin sequence) were individually resolved, and their titration behaviour in the pH range 1.2-11.5 was investigated.	Histidine	38-47	growth hormone 1	Homo sapiens	93-105
6615416-5	1983	The imidazole C-2-H resonance of histidine-151 is assigned, by comparison of its titration behaviour in human somatotropin and desamido-somatotropin (Asn-152 leads to Asp-152).	Histidine	33-42	growth hormone 1	Homo sapiens	110-122
6615416-5	1983	The imidazole C-2-H resonance of histidine-151 is assigned, by comparison of its titration behaviour in human somatotropin and desamido-somatotropin (Asn-152 leads to Asp-152).	Histidine	33-42	growth hormone 1	Homo sapiens	136-148
6873973-7	1983	The largest fraction of L-histidine uptake was inhibited by 2-amino-bicyclo (2,2,1)-heptane-2-carboxylic acid (BCH), leucine, and tryptophan.	Histidine	24-35	chimerin 2	Homo sapiens	111-114
6313550-7	1983	Among six scavengers of hydroxyl radicals and singlet oxygen that were tested, L-methionine (20-80 mM) and L-histidine (40-80 mM) were capable of preventing MIF action.	Histidine	107-118	macrophage migration inhibitory factor	Cavia porcellus	157-160
6412234-3	1983	The Tangier isoprotein 2 was shown to correspond to pro-apo A-I, having a six-amino acid amino-terminal extension with the sequence: Arg-His-Phe-Trp-Gln-Gln-.	Histidine	137-140	apolipoprotein A1	Homo sapiens	56-63
6411706-6	1983	According to the model the intermediate forms with a second order rate constant of about 30 M-1 S-1 and is probably described as a ternary complex of copper, buffer, and one or more of the histidine ligands of the binding site.	Histidine	189-198	tumor associated calcium signal transducer 2	Homo sapiens	92-99
6307694-3	1983	In human beta-endorphin, accessibility and mobility of Tyr-27 are strongly reduced in the presence of lipid at physiological pH, whereas in camel beta-endorphin His-27 becomes immobilized only at high pH.	Histidine	161-164	proopiomelanocortin	Homo sapiens	146-160
6409108-4	1983	The amino-terminal sequence of proapoA-I isolated from human lymph revealed the presence of 6 additional amino acids, Arg-His-Phe-Trp-Gln-Gln, on the amino-terminal end of apoA-I consistent with the proapoA-I sequence determined by nucleic acid sequence analysis of cloned apoA-I.	Histidine	122-125	apolipoprotein A1	Homo sapiens	172-178
6354780-8	1983	These differences in avidities suggest that HI may be useful in treatment of immune-type insulin resistance.	Histidine	44-46	insulin	Homo sapiens	89-96
6849832-0	1983	Fibrinogen Manchester: identification of an abnormal fibrinopeptide A with a C-terminal arginine leads to histidine substitution.	Histidine	106-115	fibrinogen beta chain	Homo sapiens	0-10
6811586-4	1982	This stability may be related to the unusually low cysteine and histidine content of Drosophila aldolase.	Histidine	64-73	Aldolase 1	Drosophila melanogaster	96-104
6300255-2	1983	Inhibition by anaerobiosis, azide, cyanide, halide-free conditions, catalase, histidine, and tryptophan suggested mediation of hyphal damage primarily through the myeloperoxidase system.	Histidine	78-87	myeloperoxidase	Homo sapiens	163-178
6297593-2	1983	One of these is assigned to the proximal histidine"s imidazole N-H. Its shift and pH dependence indicate that an imidazolate form, which has been postulated for peroxidases, is ruled out for cytochrome c peroxidase-cyanide.	Histidine	41-50	cytochrome c, somatic	Homo sapiens	191-203
6834030-8	1983	CuL2, the major species at neutral pH, exists in solution as an equilibrium mixture of a mixed-type chelation structure, with a glycine-like and a histamine-like bound histidine ligand, and a structure containing both histidine ligands bound histamine-like.	Histidine	168-177	cullin 2	Homo sapiens	0-4
6834030-8	1983	CuL2, the major species at neutral pH, exists in solution as an equilibrium mixture of a mixed-type chelation structure, with a glycine-like and a histamine-like bound histidine ligand, and a structure containing both histidine ligands bound histamine-like.	Histidine	218-227	cullin 2	Homo sapiens	0-4
6292103-9	1982	Damage to hyphae by the myeloperoxidase system was inhibited by azide, cyanide, catalase, histidine, and tryptophan, but not by superoxide dismutase, dimethyl sulfoxide, or mannitol.	Histidine	90-99	myeloperoxidase	Homo sapiens	24-39
6848515-8	1983	Similar His-Asp pairs have been observed in the serine proteases, thermolysin, and phospholipase A2, and the His-Asp pair may play a similar functional role in all of these enzymes.	Histidine	8-11	phospholipase A2 group IB	Homo sapiens	83-99
6848515-8	1983	Similar His-Asp pairs have been observed in the serine proteases, thermolysin, and phospholipase A2, and the His-Asp pair may play a similar functional role in all of these enzymes.	Histidine	109-112	phospholipase A2 group IB	Homo sapiens	83-99
6357563-6	1983	The minimal substrate for renin is an octapeptide segment of the protein substrate: His-Pro-Phe-His-Leu-Leu-Val-Tyr.	Histidine	84-87	renin	Homo sapiens	26-31
6357563-6	1983	The minimal substrate for renin is an octapeptide segment of the protein substrate: His-Pro-Phe-His-Leu-Leu-Val-Tyr.	Histidine	96-99	renin	Homo sapiens	26-31
6885107-9	1983	We propose that Tb3+ (by inference Ca2+) binding takes place near the CRP subunit disulfide bond, where two histidine residues are present.	Histidine	108-117	C-reactive protein	Homo sapiens	70-73
6885107-10	1983	The pH dependency of Tb3+ binding is best explained by the deprotonation of a histidine residue(s) in CRP.	Histidine	78-87	C-reactive protein	Homo sapiens	102-105
6319870-2	1983	Brain angiotensin-converting enzyme (PDP-1) cleaves Hip-His-Leu, but not 80 nM [3H-Tyr1, Leu5]-enkephalin, and is markedly inhibited by several specific inhibitors such as captopril, teprotide, and <protein-id="24590">MK-422.	Histidine	56-59	angiotensin I converting enzyme	Rattus norvegicus	6-35
6319870-3	1983	Enkephalinase</protein-id> (PDP-2) cleaves 80 nM [3H-Tyr1, Leu5]-enkephalin, but not Hip-His-Leu; it is not inhibited by any of the standard competitive inhibitors of angiotensin-converting enzyme (all analogs of carboxyl-terminal peptide sequences Phe-Ala-Pro or Ala-Pro), but is strongly inhibited by captopril analogs such as thiorphan (Phe-Gly analog).	Histidine	89-92	pyruvate dehydrogenase phosphatase catalytic subunit 2	Rattus norvegicus	28-33
7155144-1	1982	Schiff bases condensible at pH 7.0-10 after prolonged incubation with neighbouring histidine residues to yield cyclic compounds absorbing at 330 nm are formed by means of four molecules of pyridoxal-5"-phosphate (PLP) interacting with epsilon-NH2 groups of lysine in bovine serum albumin.	Histidine	83-92	albumin	Homo sapiens	280-287
7094295-4	1982	Tracer is prepared by labeling hPTH (53-84), presumably at the histidine residue, with 125I by the Chloramine T method at pH 8.6.	Histidine	63-72	parathyroid hormone	Homo sapiens	31-35
6291054-8	1982	Different Ty elements at the same site in the HIS4 regulatory region can result in His-, His+, and cold-sensitive His+ phenotypes.	Histidine	83-86	trifunctional histidinol dehydrogenase/phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase	Saccharomyces cerevisiae S288C	46-50
6291054-8	1982	Different Ty elements at the same site in the HIS4 regulatory region can result in His-, His+, and cold-sensitive His+ phenotypes.	Histidine	89-92	trifunctional histidinol dehydrogenase/phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase	Saccharomyces cerevisiae S288C	46-50
6291054-8	1982	Different Ty elements at the same site in the HIS4 regulatory region can result in His-, His+, and cold-sensitive His+ phenotypes.	Histidine	89-92	trifunctional histidinol dehydrogenase/phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase	Saccharomyces cerevisiae S288C	46-50
6289876-1	1982	The titration curves of the C-2 histidine protons of RNase A and of derivative II--a covalent derivative obtained by reaction of the enzyme with the halogenated nucleotide 9-beta-D-ribofuranosyl-6-chloropurine 5"-phosphate--in the presence of a number of purine nucleosides, nucleoside monophosphates, and nucleoside diphosphates were studied by means of proton nuclear magnetic resonance at 270 MHz.	Histidine	32-41	ribonuclease pancreatic	Bos taurus	53-60
7103928-1	1982	The histidinemic (his/his) mutant mouse shows greatly reduced skin and liver histidine:ammonia-lyase (HAL; EC 4.3.1.3) activity compared with normal mice.	Histidine	4-7	histidine ammonia lyase	Mus musculus	77-100
7118436-0	1982	The rate of s-cis/s-trans isomerization in angiotensin II is at least 70-fold greater than in His-Pro and is not rate limiting in receptor binding.	Histidine	94-97	angiotensinogen	Rattus norvegicus	43-57
6282979-6	1982	The enzymes showed the same pH optima of around 8.1 and 7.7, and Km values of 2.6 and 0.11 mm for Hip-His-Leu and angiotensin I, respectively.	Histidine	102-105	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	114-127
7103928-1	1982	The histidinemic (his/his) mutant mouse shows greatly reduced skin and liver histidine:ammonia-lyase (HAL; EC 4.3.1.3) activity compared with normal mice.	Histidine	4-7	histidine ammonia lyase	Mus musculus	102-105
7103928-1	1982	The histidinemic (his/his) mutant mouse shows greatly reduced skin and liver histidine:ammonia-lyase (HAL; EC 4.3.1.3) activity compared with normal mice.	Histidine	18-21	histidine ammonia lyase	Mus musculus	77-100
7103928-1	1982	The histidinemic (his/his) mutant mouse shows greatly reduced skin and liver histidine:ammonia-lyase (HAL; EC 4.3.1.3) activity compared with normal mice.	Histidine	18-21	histidine ammonia lyase	Mus musculus	102-105
7103934-4	1982	l-Histidine, the low-molecular-weight Ni(II)-binding constituent of human serum, is shown to have a greater affinity for Ni(II) than does HSA.	Histidine	0-11	albumin	Homo sapiens	138-141
6276387-14	1982	TRP5 mRNA levels, measured by RNA/DNA hybridization, increased 2- to 7-fold in response to starvation for either tryptophan or histidine, indicating transcriptional regulation.	Histidine	127-136	tryptophan synthase TRP5	Saccharomyces cerevisiae S288C	0-4
7050673-1	1982	The Saccharomyces cerevisiae tmp3 mutant is deficient in the mitochondrial enzyme complex that participates in the formation of one-carbon-group-tetrahydrofolate coenzymes, serine transhydroxymethylase, dihydrofolate reductase, and thymidylate synthetase, thus leading to multiple nutritional requirements of dTMP, adenine, histidine, and methionine.	Histidine	324-333	glycine hydroxymethyltransferase SHM1	Saccharomyces cerevisiae S288C	29-33
6802183-2	1982	The mechanism by which the intrinsic fluorescence of tryptophan residues in alpha-lytic protease and lysozyme are quenched by a complex formed between the single histidine residue in each protein and Ru(III)(NH3)5 was investigated.	Histidine	162-171	lysozyme	Homo sapiens	101-109
6174530-10	1982	The 26.5-kdalton band was histidine-rich and cross-reacted with the antiserum to rat filaggrin.	Histidine	26-35	filaggrin	Rattus norvegicus	85-94
7338518-3	1981	Scallop calmodulin lacked tryptophan and cysteine residues and contained one mol each of N epsilon-trimethyllysine (Tml) and histidine residues per mol of the protein.	Histidine	125-134	calmodulin	Bos taurus	8-18
6282261-11	1982	The residues forming the "charge-relay" system of the active site of serine proteinases (His-57, Asp-102 and Ser-195 in the chymotrypsinogen numbering) are found in the corresponding regions of C1r b-chain, and the amino acid sequence around these residues has been determined.	Histidine	89-92	complement C1r	Homo sapiens	194-197
6282261-13	1982	The N-terminal sequence of C1r b-chain has been extended to residue 60 and reveals that C1r b-chain lacks the "histidine loop", a disulphide bond that is present in all other known serine proteinases.	Histidine	111-120	complement C1r	Homo sapiens	88-91
7061035-2	1982	The amino acid composition and N-terminus (histidine) of the human VIP are identical to those previously reported for bovine and porcine VIP.	Histidine	43-52	vasoactive intestinal peptide	Homo sapiens	67-70
7055572-1	1982	Fibrinogen absorbed to zinc chelate columns at pH 7.8 and was eluted sharply with a pK of 5.8 indicative of the involvement of a histidine residue.	Histidine	129-138	fibrinogen beta chain	Homo sapiens	0-10
6280031-10	1982	The fact, that during alkylation of all available His in Mb the electron transfer persists in the system, points to that in the process of electron transfer to cytochrome c, uncharged group, most probably "inner" His-B5, participates.	Histidine	50-53	cytochrome c, somatic	Homo sapiens	160-172
6280031-10	1982	The fact, that during alkylation of all available His in Mb the electron transfer persists in the system, points to that in the process of electron transfer to cytochrome c, uncharged group, most probably "inner" His-B5, participates.	Histidine	213-216	cytochrome c, somatic	Homo sapiens	160-172
6776995-4	1980	The natural or synthetic Gly-Lys-Val-Asn and Phe-Glu-His-Glu had some growth hormone releasing activity while Val-Trp, Tyr-Phe and Lys-Phe-Tyr had slight prolactin releasing activity.	Histidine	53-56	growth hormone 1	Homo sapiens	70-84
7020934-1	1981	The involvement of N-hydroxylation of 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2) by cytochrome P-450 in the formation of covalent binding of Trp-P-2 to DNA, the induction of his+ revertant in the Ames test, and the formation of the active metabolite were confirmed.	Histidine	181-184	polycystin 2, transient receptor potential cation channel	Rattus norvegicus	79-86
7020934-1	1981	The involvement of N-hydroxylation of 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2) by cytochrome P-450 in the formation of covalent binding of Trp-P-2 to DNA, the induction of his+ revertant in the Ames test, and the formation of the active metabolite were confirmed.	Histidine	181-184	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	91-107
7020934-1	1981	The involvement of N-hydroxylation of 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2) by cytochrome P-450 in the formation of covalent binding of Trp-P-2 to DNA, the induction of his+ revertant in the Ames test, and the formation of the active metabolite were confirmed.	Histidine	181-184	polycystin 2, transient receptor potential cation channel	Rattus norvegicus	148-155
7035679-0	1981	1H nuclear magnetic resonance study of the histidine residues of insulin.	Histidine	43-52	insulin	Homo sapiens	65-72
6114841-0	1981	Is a photo-oxidation product of histidine one of the triggers of induction of cytochrome P-450 drug-metabolizing enzyme systems?	Histidine	32-41	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	78-94
7209542-1	1981	The affinity of the amino terminal tetrapeptide of the beta chain of fibrin, Gly-His-Arg-Pro, for fibrinogen dramatically increases in the presence of 2 millimolar calcium ion.	Histidine	81-84	fibrinogen beta chain	Homo sapiens	98-108
6155159-1	1980	In each of two families from Sardinia, Italy, we have found segregation for two alpha-chain hemoglobin variants, which we have identified as G Philadelphia [alpha 68 (E17) Asn leads to Lys] and J Sardinia [alpha 50 (CE8) His leads to Asp], respectively.	Histidine	221-224	Fc gamma receptor and transporter	Homo sapiens	80-91
6777326-6	1980	Protease solubilized NADPH-cytochrome P450 reductase is inactivated by reagents directed to histidine, arginine and lysine residues.	Histidine	92-101	cytochrome p450 oxidoreductase	Homo sapiens	21-52
6250713-7	1980	In two His+ revertants carrying reciprocal translocations, the chromosome III translocation breakpoints occur within the his4-912 insertion element.	Histidine	7-11	trifunctional histidinol dehydrogenase/phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase	Saccharomyces cerevisiae S288C	121-125
17249001-7	1980	It is proposed that the effect of THR4 is caused by aggregation of the wild-type threonine synthetase with defective his1-1S monomers, causing a favorable conformational change in the histidine protein that restores limited enzymatic activity.	Histidine	184-193	threonine synthase THR4	Saccharomyces cerevisiae S288C	34-38
7440054-5	1980	However, the resonances of Tyr-25 and His-48, which in RNase A are involved in a pH-dependent conformational transition, appeared to be different in the hybrid RNase, demonstrating that amino acid replacements may influence the structure of the protein locally.	Histidine	38-41	ribonuclease pancreatic	Bos taurus	55-62
6821370-5	1980	The binding of Co(II) to the mono-zinc(II)-enzyme caused only one marked change in the spectrum, namely a decrease in the intensity of the resonances assigned to the C-2 and C-4 protons of one histidine residue (residue E).	Histidine	193-202	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-21
6821370-7	1980	A significant fraction of the protons in the whole molecule are affected by the binding of Co(II) at the first metal-ion-binding site (where the ligands are the enzyme"s sole thiol group and three histidine residues).	Histidine	197-206	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-97
6997877-10	1980	The active-site residues typical of the serine proteases, histidine-57 and serine-195, are replaced in haptoglobin by lysine and alanine, respectively; however, aspartic acid-102 and the trypsin specificity, residue, aspartic acid-189, do occur in haptoglobin.	Histidine	58-67	haptoglobin	Homo sapiens	103-114
7356955-3	1980	To further elucidate the role of histidine-48 in the active center of pancreatic phospholipase A2, we have modified the enzyme with a number of bromo ketones and methyl benzenesulfonates.	Histidine	33-42	phospholipase A2	Equus caballus	81-97
6928653-1	1980	[1-Sarcosine,8-isoleucine]angiotensin II (Sar-Arg-Val-Tyr-Ile-His-Pro-Ile) has been shown to be a potent antagonist of the pressor action of angiotensin II.	Histidine	62-65	angiotensinogen	Homo sapiens	26-40
7352997-5	1980	The aromatic region of the NMR spectrum of glycophorin A in 2H2O shows single, well-resolved His and Tyr resonances.	Histidine	93-96	glycophorin A (MNS blood group)	Homo sapiens	43-56
6928653-1	1980	[1-Sarcosine,8-isoleucine]angiotensin II (Sar-Arg-Val-Tyr-Ile-His-Pro-Ile) has been shown to be a potent antagonist of the pressor action of angiotensin II.	Histidine	62-65	angiotensinogen	Homo sapiens	141-155
6928653-6	1980	The results indicated that: (i) angiotensin II and [1-sarcosine,8-isoleucine]angiotensin II gave practically identical spectroscopic data; and (ii) N-methylation in either position 4 or position 5 resulted in remarkable changes in the peptide backbone and a severe limitation in rotational freedom of side chains in tyrosine, isoleucine, and histidine residues.	Histidine	342-351	angiotensinogen	Homo sapiens	32-46
6928653-6	1980	The results indicated that: (i) angiotensin II and [1-sarcosine,8-isoleucine]angiotensin II gave practically identical spectroscopic data; and (ii) N-methylation in either position 4 or position 5 resulted in remarkable changes in the peptide backbone and a severe limitation in rotational freedom of side chains in tyrosine, isoleucine, and histidine residues.	Histidine	342-351	angiotensinogen	Homo sapiens	77-91
41741-0	1979	Resolution of specific histidine resonances in the 360 MHz 1H NMR spectrum of glyceraldehyde-3-phosphate dehydrogenase, a 145 000 molecular weight protein, by photo-CIDNP.	Histidine	23-32	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	78-118
39752-5	1979	This permitted the identification of the C-4 proton resonance of His-119.	Histidine	65-68	complement C4	Bos taurus	41-44
500618-0	1979	Reaction of the histidines of prolactin with ethoxyformic anhydride.	Histidine	16-26	prolactin	Bos taurus	30-39
500618-2	1979	The seven histidines of bovine prolactin were modified with ethoxyformic anhydride and two classes of reactivity were apparent: 5 histidines were in the more reactive class (k = 0.097 min-1) and 2 histidines were less reactive (k = 0.011 min-1).	Histidine	10-20	prolactin	Bos taurus	31-40
500618-2	1979	The seven histidines of bovine prolactin were modified with ethoxyformic anhydride and two classes of reactivity were apparent: 5 histidines were in the more reactive class (k = 0.097 min-1) and 2 histidines were less reactive (k = 0.011 min-1).	Histidine	130-140	prolactin	Bos taurus	31-40
500618-2	1979	The seven histidines of bovine prolactin were modified with ethoxyformic anhydride and two classes of reactivity were apparent: 5 histidines were in the more reactive class (k = 0.097 min-1) and 2 histidines were less reactive (k = 0.011 min-1).	Histidine	130-140	prolactin	Bos taurus	31-40
500618-4	1979	This assay showed that prolactin was fully active when 0 to 5 histidines were modified.	Histidine	62-72	prolactin	Bos taurus	23-32
232232-2	1979	We found that deletions of histidine operon, unit 44 of the chromosome map, changed the linkage of markers purF and aroC (unit 49) and pyrF and trpA (unit 34).	Histidine	27-36	tryptase gamma 1	Homo sapiens	144-148
379004-2	1979	The his4 region of yeast encodes the information for the third (phosphoribosyl-AMP cyclohydrolase), second (phosphoribosyl-ATP pyrophosphohydrolase), and tenth (histidinol dehydrogenase) steps in the histidine biosynthetic pathway.	Histidine	200-209	trifunctional histidinol dehydrogenase/phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase	Saccharomyces cerevisiae S288C	4-8
39752-7	1979	The resonances of the ring protons of Tyr-25, Tyr-76 and Tyr-115 and the C-4 proton of His-12 were identified by comparison with subtilisin-modified and nitrated ribonucleases.	Histidine	87-90	complement C4	Bos taurus	73-76
464051-3	1979	Synthetic inhibitor studies indicate that mouse acrosin has a serine and histidine at its active site and hydrolyzes the peptide bonds of lysine and arginine but of not phenylalanine.	Histidine	73-82	acrosin prepropeptide	Mus musculus	48-55
570855-4	1979	The effects of taurodeoxycholate (TDC) and a positively charged deoxycholate derivative on the aromatic region of the colipase NMR spectrum indicate that all tyrosines and one histidine are affected by the bile-salt binding, suggesting that the TDC molecules bind near these residues to a hydrophobic region on colipase.	Histidine	176-185	colipase	Homo sapiens	118-126
34614-7	1979	Tryptic digestion is also retarded by some of the feedback inhibitors of glutamine synthetase including CTP, L-alanine, L-serine, L-histidine, and glucosamine 6-phosphate.	Histidine	130-141	AT695_RS11110	Staphylococcus aureus	73-93
16345376-5	1979	The uptake of histidine as analyzed through the measurement of oxygen uptake rates was characterized by a saturation constant of 1.7 to 10.5 muM histidine; the maximum uptake rate was always greater than the actual histidine uptake rate in the culture.	Histidine	14-23	latexin	Homo sapiens	141-144
16345376-5	1979	The uptake of histidine as analyzed through the measurement of oxygen uptake rates was characterized by a saturation constant of 1.7 to 10.5 muM histidine; the maximum uptake rate was always greater than the actual histidine uptake rate in the culture.	Histidine	145-154	latexin	Homo sapiens	141-144
16345376-5	1979	The uptake of histidine as analyzed through the measurement of oxygen uptake rates was characterized by a saturation constant of 1.7 to 10.5 muM histidine; the maximum uptake rate was always greater than the actual histidine uptake rate in the culture.	Histidine	145-154	latexin	Homo sapiens	141-144
30487-0	1978	The involvement of one of the three histidine residues of cow kappa-casein in the chymosin-initiated milk clotting process.	Histidine	36-45	casein kappa	Bos taurus	62-74
751649-1	1978	Variation in activity of the main histidine catabolic enzymes (histidase, urocanase, and aminotransferase) has been surveyed using inbred strains of mice (C57BL, DBA, Peru, SM, and SWR).	Histidine	34-43	histidine ammonia lyase	Mus musculus	63-72
35741-3	1979	All the steps of L-histidine metabolism have been studied: it has been found that both the histidine transaminase pathway and the histidase pathway are stimulated.	Histidine	17-28	histidine ammonia lyase	Rattus norvegicus	130-139
35741-4	1979	Glutamic acid is also a product of histidine catabolism through the histidase pathway, but its catabolism is unaffected by the dietary protein content.	Histidine	35-44	histidine ammonia lyase	Rattus norvegicus	68-77
30487-5	1978	Of the amino acids examined it is concluded that only the histidine residues of cow kappa-casein are important for the hydrolytic action of chymosin and, furthermore, the treatment with diethyl pyrocarbonate suggests that only one of the three histidines plays an essential role.	Histidine	58-67	casein kappa	Bos taurus	84-96
656461-5	1978	This suggests that anhydride leghemoglobin has a conformation with a covalent attachment via propionic acid side chain to lysine-57 and the sixth coordination position of the heme iron occupied by the distal histidine at position 61.	Histidine	208-217	leghemoglobin A	Glycine max	29-42
80265-3	1978	Alpha-fetoprotein bound 1 mol of copper(II) ion per mol of protein above pH 6.0 and 0.5 mol of copper(II) ion at pH 5.4, which is close to the pK value of the imidazole group of histidine.	Histidine	178-187	alpha fetoprotein	Homo sapiens	0-17
27248-0	1978	[Presence of SH-groups and histidine in the active site of Chlorella glutamine synthetase].	Histidine	27-36	glutamate-ammonia ligase	Homo sapiens	69-89
629933-5	1978	The residues forming the "charge-relay" system of the active site of chymotrypsin (His-57, Asp-102, and Ser-195) are found in corresponding regions in GSP, whereas an alanyl residue at position 176 of GSP corresponds to a residue which participates in the primary substrate binding site in serine proteases (Asp-177 in trypsin; Ser-189 in chymotrypsin).	Histidine	83-86	mast cell protease 2	Rattus norvegicus	151-154
24636-0	1978	A proton magnetic resonance study of the distal histidine of soybean Leghemoglobin.	Histidine	48-57	leghemoglobin A	Glycine max	69-82
658038-0	1978	Evidence for essential histidine residues in tryptophanyl-tRNA synthetase.	Histidine	23-32	tryptophanyl-tRNA synthetase 1	Homo sapiens	45-73
620051-4	1978	It was shown that illumination of photooxidized fibrinogen and photooxidized fragment N-DSK caused the modification of histidine residues.	Histidine	119-128	fibrinogen beta chain	Homo sapiens	48-58
415861-0	1978	The chemistry of the reaction of 2-hydroxy-5-nitrobenzyl bromide with his-32 of alpha-lactalbumin.	Histidine	70-73	lactalbumin alpha	Homo sapiens	80-97
415861-1	1978	His-32 of bovine or human alpha-lactalbumin reacts with the tryptophan reagent 2-hydroxy-5-nitrobenzyl bromide at pH 7.	Histidine	0-3	lactalbumin alpha	Homo sapiens	26-43
14035-10	1976	On the other hand, histidine significantly stimulated prolactin secretion in chlorpheniramine-treated rats.	Histidine	19-28	prolactin	Rattus norvegicus	54-63
223580-4	1978	The ACTH 4--9 analog H-Met(O2)-Glu-His-Phe-D-Lys-Phe-OH (Org 2766) has behavioral activity after oral administration.	Histidine	35-38	proopiomelanocortin	Homo sapiens	4-8
200428-5	1977	The direct interaction between borate (if present at concentration of at least 6 mM) and glyceraldehyde-3-phosphate dehydrogenase is postulated, the possible site of the reaction being the histidine residue(s).	Histidine	189-198	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	89-129
200440-4	1977	The peptide ACTH 4--10 was ineffective, whereas another ACTH derivative H-Met(O2)-Glu-His-Phe-D-Lys-Phe-OH (Org 2766) reduced PRL release.	Histidine	86-89	prolactin	Rattus norvegicus	126-129
19461-0	1977	Spectral perturbations of the histidine and tryptophan in cobra venom phospholipase A2 upon metal ion and mixed micelle binding.	Histidine	30-39	phospholipase A2 group IB	Homo sapiens	70-86
19034-1	1977	The properties of aqueous solutions of synthetic renin substrate tetradecapeptide (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Leu-Val-Tyr-Ser) were examined through electrometric titrations, infrared and circular dichroism spectroscopy, and spectrofluorometry.	Histidine	103-106	renin	Homo sapiens	49-54
19034-1	1977	The properties of aqueous solutions of synthetic renin substrate tetradecapeptide (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Leu-Val-Tyr-Ser) were examined through electrometric titrations, infrared and circular dichroism spectroscopy, and spectrofluorometry.	Histidine	115-118	renin	Homo sapiens	49-54
19034-2	1977	Titration studies of angiotensin I (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu) were also made, whose results indicated a flexible folded conformation similar to that previously proposed for the octapeptide angiotensin II, with a possible additional beta turn at the C terminus.	Histidine	56-59	angiotensinogen	Homo sapiens	21-34
19034-3	1977	The experimental results of the tetradecapeptide study, associated with Chou and Fasman calculations and with an analysis of structure-activity relationships in renin substrates and competitive inhibitors, led to the proposal of a beta turn involving the His-Pro-Phe-His sequence of the tetradecapeptide.	Histidine	255-258	renin	Homo sapiens	161-166
37434-5	1977	Two histidine residues of myoglobin, His A10 and His GH1, are shown to take part in the realization of the "active" contact between the molecules in the course of the reaction.	Histidine	4-13	growth hormone 1	Homo sapiens	53-56
194605-1	1977	The polypeptides ACTH and ATCH4-10 (OI 63) witha sequence of amino acids H-Met-Glu-His-Phe-Arg-Trp-Gly-OH, have similar stimulating effects  on motor units in lower mammals.	Histidine	83-86	proopiomelanocortin	Homo sapiens	17-21
13994-1	1977	Irradiation with visible light of human serum albumin in aqueous solution at pH 8, in the presence of catalytic amounts of rose bengal or methylene blue, resulted in random oxidation of the histidine residues in the protein under consumption of one mole O2, and release of somewhat less than one proton, per histidine residue degraded.	Histidine	190-199	albumin	Homo sapiens	46-53
13994-1	1977	Irradiation with visible light of human serum albumin in aqueous solution at pH 8, in the presence of catalytic amounts of rose bengal or methylene blue, resulted in random oxidation of the histidine residues in the protein under consumption of one mole O2, and release of somewhat less than one proton, per histidine residue degraded.	Histidine	308-317	albumin	Homo sapiens	46-53
13994-5	1977	Further, a sensitized oligomerization of albumin was observed, independent of oxidation of the histidine residues, and not consuming oxygen.	Histidine	95-104	albumin	Homo sapiens	41-48
184092-10	1976	These findings lead us to picture leghemoglobin as a somewhat flexible molecule in which the transition region between the E and F helices may act as a hinge, opening a small amount at higher temperature to a stable configuration in which the protein is high spin and can accommodate exogenous ligand molecules and closing at low temperature to a second stable configuration in which the protein is low spin and in which close approach of the E helix permits the distal histidine to become the principal sixth ligand.	Histidine	470-479	leghemoglobin A	Glycine max	34-47
8133-6	1976	These findings demonstrate that histidine ammonia-lyase is the rate-limiting factor in L-histidine degradation in the rat.	Histidine	87-98	histidine ammonia lyase	Rattus norvegicus	32-55
667168-2	1978	The sequence of chicken histone H2A differs from the calf homologous histone by the deletion of one residue of histidine at position 123 or 124 and three conservative substitutions: a residue of serine replaces a residue of threonine at position 16, a residue of aspartic acid replaces a residue of glutamic acid at position 121 and a residue of alanine replaces a residue of glycine at position 128.	Histidine	111-120	H2A histone family, member J	Gallus gallus	24-35
558796-1	1977	The chemical reactivity of histidines in ovotransferrin and human serum transferrin was studied utilizing two different reactions.	Histidine	27-37	transferrin	Homo sapiens	44-55
558796-2	1977	Upon dye-sensitized photooxidation of ovotransferrin and ethoxyformylation of human serum transferrin and ovotransferrin, losses in histidine and iron-binding activity were observed.	Histidine	132-141	transferrin	Homo sapiens	41-52
558796-4	1977	The histidines of human serum transferrin showed a greater reactivity toward the reagent than did those of ovotransferrin.	Histidine	4-14	transferrin	Homo sapiens	30-41
1009126-4	1976	Several analogs of the octapeptide segment: His-Pro-Phe-His-Leu-Leu-Val-Tyr of this tetradecapeptide act as competitive inhibitors for human renin with inhibition constants down to 1 muM.	Histidine	44-47	renin	Homo sapiens	141-146
984842-0	1976	Chemical modification of histidine residues of rabbit hemopexin.	Histidine	25-34	hemopexin	Oryctolagus cuniculus	54-63
14035-11	1976	In contrast, histidine depressed plasma prolactin levels in metiamide-treated rats.	Histidine	13-22	prolactin	Rattus norvegicus	40-49
982622-1	1976	The interaction of diethylpyrocarbonate (DEP) with the pyruvate dehydrogenase component (PDH) isolated from the pyruvate dehydrogenase complex (EC 1.2.4.1) results in a modification of 3-5 histidine residues per mole of enzyme, which simultaneously decreases the enzyme activity.	Histidine	189-198	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	89-92
12142-1	1976	V. Ethoxyformylation of histidine and tyrosine residues of catalase with diethylpyrocarbonate.	Histidine	24-33	catalase	Homo sapiens	59-67
12142-2	1976	In order to elucidate the possible roles of histidine and tyrosine residues of catalase [EC 1.11.1.6] in maintaining the quaternary structure and catalatic activity, diethylpyrocarbonate modification experiments were carried out.	Histidine	44-53	catalase	Homo sapiens	79-87
12142-8	1976	More EF-His residues were formed by the reaction of diethyl pyrocarbonate with cyanoethylated (CE)-catalase monomer (subunit) than with CE-catalase tetramer.	Histidine	8-11	catalase	Homo sapiens	99-107
12142-8	1976	More EF-His residues were formed by the reaction of diethyl pyrocarbonate with cyanoethylated (CE)-catalase monomer (subunit) than with CE-catalase tetramer.	Histidine	8-11	catalase	Homo sapiens	139-147
982622-11	1976	it is concluded that the histidine residues of PDH are involved in TPP binding.	Histidine	25-34	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	47-50
1091-6	1975	The most striking differences were the loss of one histidine and one methionine in the isoenzyme, corresponding to residues 24 and 27, respectively, in alpha-phospholipase A2.	Histidine	51-60	phospholipase A2 group IB	Homo sapiens	158-174
1247522-6	1976	Each antithrombin III is composed of a single polypeptide chain with an amino-terminal histidine residue.	Histidine	87-96	serpin family C member 1	Bos taurus	5-21
212233-6	1976	The following conclusion was drawn: alpha-MSH possesses (in contrast to ACTH) two message sequences (active sites), (i)-Glu-His-Phe-Arg-Trp-, and (ii)-Gly-Lys-Pro-Val-NH2 which are capable of independently triggering the hormone receptor responsible for melanin dispersion.	Histidine	124-127	proopiomelanocortin	Homo sapiens	36-45
1260027-6	1976	The spectra of both the mono- and bis-imidazole complex concur in predicting that only the 2-H and 5-CH2 signals of an axial histidine are likely to resonate clearly outside the diamagnetic 0 to --10 ppm from TMS region in hemoproteins.	Histidine	125-134	PYD and CARD domain containing	Homo sapiens	209-212
238587-0	1975	Assignment of the histidine proton magnetic resonance peaks of soybean trypsin inhibitor (Kunitz) by a differertial deuterium exchange technique.	Histidine	18-27	kunitz trypsin protease inhibitor	Glycine max	71-88
1158867-5	1975	Evidence that histidine residues of hemopexin participate in the binding of heme was obtained by photooxidation of hemopexin sensitized by rose bengal.	Histidine	14-23	hemopexin	Oryctolagus cuniculus	36-45
1158867-5	1975	Evidence that histidine residues of hemopexin participate in the binding of heme was obtained by photooxidation of hemopexin sensitized by rose bengal.	Histidine	14-23	hemopexin	Oryctolagus cuniculus	115-124
1158867-6	1975	Progressive modification of the 16 histidine residues of hemopexin is effected by illumination of the dye-hemopexin complexes.	Histidine	35-44	hemopexin	Oryctolagus cuniculus	57-66
1158867-6	1975	Progressive modification of the 16 histidine residues of hemopexin is effected by illumination of the dye-hemopexin complexes.	Histidine	35-44	hemopexin	Oryctolagus cuniculus	106-115
1158867-9	1975	At that time, approximately 2 more histidine residues are modified in apo-hemopexin than in deuteroheme-hemopexin, and no change is found in other potentially photolabile amino acid residues.	Histidine	35-44	hemopexin	Oryctolagus cuniculus	74-83
2584-7	1975	Accordingly two axial ligands are likely to be histidine and methionine as in cytochrome c.	Histidine	47-56	cytochrome c, somatic	Homo sapiens	78-90
1157951-0	1975	Comparative study on histidine modification by diethylpyrocarbonate in human serotransferrin and lactotransferrin.	Histidine	21-30	transferrin	Homo sapiens	77-92
1157951-0	1975	Comparative study on histidine modification by diethylpyrocarbonate in human serotransferrin and lactotransferrin.	Histidine	21-30	lactotransferrin	Homo sapiens	97-113
238587-1	1975	Deuterium exchange at the C(2)-H position of the two histidine residues of native soybean trypsin inhibitor (Kunitz) in 2-H2O was followed by 1-H nuclear magnetic resonance (NMR) spectroscopy.	Histidine	53-62	kunitz trypsin protease inhibitor	Glycine max	90-107
238587-2	1975	The two histidine residues of soybean trypsin inhibitor exchange at significantly different rates at pH* 5.00, 40 degrees.	Histidine	8-17	kunitz trypsin protease inhibitor	Glycine max	38-55
238587-4	1975	Differentially deuterated soybean trypsin inhibitor was cleaved by cyanogen bromide into two fragments each containing one histidine residue.	Histidine	123-132	kunitz trypsin protease inhibitor	Glycine max	34-51
238587-8	1975	These assignments were extended to the histidine peaks of trypsin-modified soybean trypsin inhibitor by converting the differentially deuterated virgin soybean trypsin inhibitor to the modified form.	Histidine	39-48	kunitz trypsin protease inhibitor	Glycine max	83-100
238587-8	1975	These assignments were extended to the histidine peaks of trypsin-modified soybean trypsin inhibitor by converting the differentially deuterated virgin soybean trypsin inhibitor to the modified form.	Histidine	39-48	kunitz trypsin protease inhibitor	Glycine max	160-177
238587-10	1975	The results demonstrate that His-71 is the residue whose pK value is raised from 5.27 to 5.91 on trypsin modification of soybean trypsin inhibitor [Markley, J. L., (1973), Biochemistry 12, 2245].	Histidine	29-32	kunitz trypsin protease inhibitor	Glycine max	129-146
47704-18	1975	Antithrombin III neutralizes the activity of prethrombin-E and thrombin-E; consequently, an active histidine center found in the B1 chain of thrombin is not essential for the binding of antithrombin.	Histidine	99-108	coagulation factor II, thrombin	Homo sapiens	4-12
1098653-11	1975	The utility of the method is demonstrated by repeating the determination of the substitution in haemoglobin Hopkins-2, a known alpha-chain core variant in which histidine-alpha112 (G19) is replaced by an aspartic acid residue.	Histidine	161-170	Fc gamma receptor and transporter	Homo sapiens	127-138
1121503-5	1975	These findings demonstrate that hemopexin is cleared and catabolized at an enhanced rate during states of plasma heme load, and that modification of critical histidine residues of hemopexin eliminates its biological function in plasma heme disposal.	Histidine	158-167	hemopexin	Oryctolagus cuniculus	180-189
4463943-3	1974	The selective isolation of an ;active" histidine peptide from reduced and cyanoethylated chymotrypsin-alpha inhibited with Tos-Phe-CH(2)Cl (l-1-tosylamido-2-phenylethyl chloromethyl ketone) was obtained with a His(tauCm) (N(tau)-carboxymethylhistidine) diagonal peptide-;mapping" technique.	Histidine	39-48	immunoglobulin kappa variable 1-16	Homo sapiens	140-143
48419-8	1975	The following amino acids were found in CEA: lysine, histidine, arginine, aspartic acid, threonine, serine, glutamic acid, proline, glycine, alanine, valine, emthionine, isoleucine, leucine, tyrosine, phenylalanine, and cysteine.	Histidine	53-62	CEA cell adhesion molecule 3	Homo sapiens	40-43
1197263-5	1975	But under histidine treatment a significant rise of transferrin levels occurred in RDT patients, so that histidine must be considered as a limiting factor in protein metabolism in these cases.	Histidine	10-19	transferrin	Homo sapiens	52-63
1197263-5	1975	But under histidine treatment a significant rise of transferrin levels occurred in RDT patients, so that histidine must be considered as a limiting factor in protein metabolism in these cases.	Histidine	105-114	transferrin	Homo sapiens	52-63
4462579-5	1974	Urate synthesis from glycine, glutamine, NH(4)Cl, asparagine, alanine, histidine and a mixture of 21 amino acids was obtained on inclusion of insulin in the perfusion medium.	Histidine	71-80	insulin	Gallus gallus	142-149
4368759-1	1974	The mammalian-type cytochrome c of the basidiomycete Ustilago sphaerogena contains in a single polypeptide chain of 107 residues, two histidine residues located at positions 18 and 33, and one methionine residue situated at position 80 (Bitar et al., 1972).	Histidine	134-143	cytochrome c, somatic	Homo sapiens	19-31
4444649-0	1974	[The influence of l-histidine substitution on protein metabolism (transferrin and complement system) and renal anaemia in endstage renal failure (author"s transl)].	Histidine	18-29	transferrin	Homo sapiens	66-77
4375978-4	1974	It appears to be related to the beta-MSH species of mammalian species but has only the sequence -His-Phe-Arg-Trp- in common with the heptapeptide core -Met-Glu-His-Phe-Arg-Trp-Gly- which is characteristic not only of the MSH peptides but also of the adrenocorticotrophins and lipotrophins studied so far.	Histidine	160-163	proopiomelanocortin	Homo sapiens	32-40
4856505-0	1974	Histidine at the active site of phospholipase A2.	Histidine	0-9	phospholipase A2 group IB	Homo sapiens	32-48
4463943-3	1974	The selective isolation of an ;active" histidine peptide from reduced and cyanoethylated chymotrypsin-alpha inhibited with Tos-Phe-CH(2)Cl (l-1-tosylamido-2-phenylethyl chloromethyl ketone) was obtained with a His(tauCm) (N(tau)-carboxymethylhistidine) diagonal peptide-;mapping" technique.	Histidine	210-213	immunoglobulin kappa variable 1-16	Homo sapiens	140-143
4555980-2	1972	The analog in which glycine was substituted for histidine at position 2, [Gly(2)]LRF, behaves as a partial agonist releasing less than 50 percent of the luteinizing hormone secreted at maximum concentrations of the releasing factor, while the analog in which histidine at position 2 is deleted has no significant agonist activity at any of the doses tested.	Histidine	48-57	zinc finger and BTB domain containing 7a	Rattus norvegicus	81-84
4696695-0	1973	Simultaneous identification of PTH derivatives of histidine and arginine by thin-layer chromatography.	Histidine	50-59	parathyroid hormone	Homo sapiens	31-34
4772291-0	1973	[Alkylation of histidine residues of horse myoglobin.	Histidine	15-24	myoglobin	Equus caballus	43-52
4772291-1	1973	Study of 1-CM His-113 myoglobin].	Histidine	14-17	myoglobin	Equus caballus	22-31
5144756-2	1971	Both growth hormone and insulin, when present in the medium separately, stimulated the incorporation into protein of the amino acids, leucine, arginine, valine, lysine and histidine.	Histidine	172-181	somatotropin	Oryctolagus cuniculus	5-19
4675202-0	1972	Hydrogen ion titration study of the histidine residues of horse myoglobin.	Histidine	36-45	myoglobin	Equus caballus	64-73
5529636-0	1970	Binding of aquocobalamin to the histidine residues in bovine serum albumin.	Histidine	32-41	albumin	Homo sapiens	61-74
11945956-0	1971	Proton magnetic resonance study of the histidine residues of horse myoglobin.	Histidine	39-48	myoglobin	Equus caballus	67-76
4309308-8	1969	Insulin increased the uptake by isolated heart cells of several (14)C-labelled naturally occurring amino acids; however, the fraction of amino acid taken up by the cells that was recovered free intracellularly, and therefore the concentration ratio (between intracellular water and medium), was enhanced by the hormone only with glycine, proline, serine, threonine, histidine and methionine.	Histidine	366-375	insulin	Gallus gallus	0-7
5419743-9	1970	However, two of these amino acids, alanine and histidine, here showed response to insulin in the absence of inhibitor.	Histidine	47-56	insulin	Homo sapiens	82-89
5355345-5	1969	The asparagine residue G10(108)beta lies in the internal cavity of the tetrameric molecule and its main chain carbonyl is thought to be hydrogen bonded to histidine G10(103)alpha at the region of contact between alpha- and beta-chains.	Histidine	155-164	Fc gamma receptor and transporter	Homo sapiens	212-234
5366994-2	1969	Chemical accessibility of histidine and tyrosine residues in insulin as examined with diazonium-1-H-tetrazole.	Histidine	26-35	insulin	Homo sapiens	61-68
5476715-3	1970	The sequence of the hormone, Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Met, shows that ten of its 11 residues are the same as ten of the 13 residues of mammalian alpha-MSH.	Histidine	41-44	proopiomelanocortin	Homo sapiens	160-169
5260920-1	1969	The his4 region of yeast contains the information necessary for the catalysis of three steps in the histidine biosynthetic pathway.	Histidine	100-109	trifunctional histidinol dehydrogenase/phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase	Saccharomyces cerevisiae S288C	4-8
6061695-0	1967	Demonstration of the presence of a histidine residue at the active site of streptococcal proteinase.	Histidine	35-44	endogenous retrovirus group K member 25	Homo sapiens	89-99
5662012-10	1968	It is suggested that the compounds his(6)-pro(7)-phe(8)-his(9)-leu(10)-leu(11)-val(12)-tyr(13)-ser(14) or his(6)-pro(7)-phe(8)-his(9)-leu(10)-leu(11)-val(12)-tyr(13) might be used as substrates for the chemical assay and standardization of renin.	Histidine	35-38	renin	Homo sapiens	240-245
5662012-10	1968	It is suggested that the compounds his(6)-pro(7)-phe(8)-his(9)-leu(10)-leu(11)-val(12)-tyr(13)-ser(14) or his(6)-pro(7)-phe(8)-his(9)-leu(10)-leu(11)-val(12)-tyr(13) might be used as substrates for the chemical assay and standardization of renin.	Histidine	56-59	renin	Homo sapiens	240-245
5662012-10	1968	It is suggested that the compounds his(6)-pro(7)-phe(8)-his(9)-leu(10)-leu(11)-val(12)-tyr(13)-ser(14) or his(6)-pro(7)-phe(8)-his(9)-leu(10)-leu(11)-val(12)-tyr(13) might be used as substrates for the chemical assay and standardization of renin.	Histidine	56-59	renin	Homo sapiens	240-245
5662012-10	1968	It is suggested that the compounds his(6)-pro(7)-phe(8)-his(9)-leu(10)-leu(11)-val(12)-tyr(13)-ser(14) or his(6)-pro(7)-phe(8)-his(9)-leu(10)-leu(11)-val(12)-tyr(13) might be used as substrates for the chemical assay and standardization of renin.	Histidine	56-59	renin	Homo sapiens	240-245
5862203-2	1965	Heme-linked histidine residues in cytochrome c as determined with diazonium-1-H-tetrazole.	Histidine	12-21	cytochrome c, somatic	Homo sapiens	34-46
15938304-0	1967	Influence of transferrin saturation on the effect of intraluminal fructose or histidine on iron absorption.	Histidine	78-87	transferrin	Homo sapiens	13-24
6034638-0	1967	The relationship of histochemically reactive histidine to histidase activity in the epidermis of growing rats.	Histidine	45-54	histidine ammonia lyase	Rattus norvegicus	58-67
4223518-0	1966	Effect of L-histidine on hepatic histidine ammonia-lyase &amp; histidine-pyruvate aminotransferase levels in rats.	Histidine	10-21	histidine ammonia lyase	Rattus norvegicus	33-56
5882713-0	1965	[Alkylation of histidine radicals in the active center of horse myoglobin].	Histidine	15-24	myoglobin	Equus caballus	64-73
13463253-1	1957	A purified preparation of a polypeptide renin substrate prepared by tryptic degradation of the protein renin substrate has been analyzed by the fluorodinitrobenzene method and after degradation with renin, carboxypeptidase, and phenylisothiocyanate, has been found to possess the amino acid sequence; asp-arg-val-tyr-ileu-his-pro-phe-his-leu-leu-val-tyr-ser.	Histidine	334-337	renin	Homo sapiens	40-45
13463253-1	1957	A purified preparation of a polypeptide renin substrate prepared by tryptic degradation of the protein renin substrate has been analyzed by the fluorodinitrobenzene method and after degradation with renin, carboxypeptidase, and phenylisothiocyanate, has been found to possess the amino acid sequence; asp-arg-val-tyr-ileu-his-pro-phe-his-leu-leu-val-tyr-ser.	Histidine	322-325	renin	Homo sapiens	40-45
14342228-13	1965	The arteriovenous differences obtained for arginine, glutamine, isoleucine, leucine, lysine, valine, threonine and histidine were probably large enough to provide all the respective amino acid residues in milk protein.	Histidine	115-124	casein beta	Bos taurus	205-217
14190977-0	1964	SUBSTITUTION OF TYROSINE FOR HISTIDINE (87 IN THE ALPHA-CHAIN OF HEMOGLOBIN M-IWATE).	Histidine	29-38	Fc gamma receptor and transporter	Homo sapiens	50-61
14239413-0	1964	THE EXISTENCE OF A HISTIDINE RESIDUE ESSENTIAL FOR GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE ACTION.	Histidine	19-28	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	51-91
33873056-6	2021	The distances from ADP to the His20 in the His-Ser-His motif and the Arg finger (Arg353 or Arg378) in both RUVBL1/2 complex structures bound with or without ADP have significant differences, suggesting dramatically different interactions of the binding site with ADP.	Histidine	30-33	RuvB like AAA ATPase 1	Homo sapiens	107-115
13235875-0	1955	Position and reactivity of the histidine residues in cytochrome c.	Histidine	31-40	cytochrome c, somatic	Homo sapiens	53-65
15436813-0	1950	Influence of ACTH on the excretion of histamine and histidine in patients with allergic states or rheumatoid arthritis.	Histidine	52-61	proopiomelanocortin	Homo sapiens	13-17
15440791-0	1950	Apparent free histidine plasma and urine values in rheumatoid arthritis treated with cortisone and ACTH.	Histidine	14-23	proopiomelanocortin	Homo sapiens	99-103
33784510-4	2021	This mutation led to a tyrosine to histidine (YH) substitution in both cytosolic and mitochondrial LysRS proteins, and decreased their aminoacylation activity to different levels.	Histidine	35-44	lysyl-tRNA synthetase 1	Homo sapiens	99-104
33452697-7	2021	Furthermore, using an amplified luminescent proximity homogeneous assay (Alpha) with GST-TXNIP and His-NLRP3, we obtained a small molecule named PSSM1443 that could disrupt the TXNIP-NLRP3 interaction in vitro, impairing NLRP3 downstream events.	Histidine	99-102	thioredoxin interacting protein	Mus musculus	177-182
33554371-8	2021	In addition, there was an increase in the activity of superoxide dismutase, catalase, peroxidase, and ascorbate peroxidase antioxidant enzymes in leaves due to HI, regardless of FC.	Histidine	160-162	peroxidase	Glycine max	86-96
33554371-8	2021	In addition, there was an increase in the activity of superoxide dismutase, catalase, peroxidase, and ascorbate peroxidase antioxidant enzymes in leaves due to HI, regardless of FC.	Histidine	160-162	peroxidase	Glycine max	112-122
34053754-16	2021	Additionally, the observation that plasma His and milk protein increased with the consumption of HFM containing more blood suggests that His may have played a role in increasing milk and milk protein yield.	Histidine	42-45	casein beta	Bos taurus	187-199
33359310-2	2021	In this study, we investigated the ability of His-Ala-Val (HAV) and Ala-Asp-Thr (ADT) peptides derived from the extracellular-1 (EC1) domain of E-cadherin proteins to increase the paracellular permeation and intestinal bioavailability of the poorly permeable model macromolecule, fluorescein-isothiocyanate dextran with average molecular weight 4000 (FD4).	Histidine	46-49	cadherin 1	Homo sapiens	144-154
33876044-3	2021	Assignment of the experimental photoelectron spectra of the C1s and N1s levels allows the determination of the protonation state of histidine in these aqueous aerosols and is confirmed by density functional calculations.	Histidine	132-141	complement C1s	Homo sapiens	60-63
33512531-3	2021	Disease arises from somatic gain-of-function variants at the R201 codon in GNAS, replacing arginine by either cysteine or histidine.	Histidine	122-131	GNAS complex locus	Homo sapiens	75-79
33658341-5	2021	Replacement of wildtype Env375 residues by Trp, Tyr, Phe or His in the other nine SHIVs led to efficient replication in rhesus CD4+ T cells in vitro and in vivo Nine SHIVs containing optimized Env375 alleles were grown large-scale in primary rhesus CD4+ T cells to serve as challenge stocks in preclinical prevention trials.	Histidine	60-63	CD4 molecule	Homo sapiens	127-130
33838185-5	2021	The recombinant PPARalpha subunit protein, containing His-tag, was purified by affinity column chromatography using Ni-NTA affinity column.	Histidine	54-57	peroxisome proliferator activated receptor alpha	Gallus gallus	16-25
33175409-6	2021	The histidine (His-18) moiety close to hemin group is mainly responsible for proton abstraction to promote the concerted E2 pathway for KE catalysis when cyt c is in oxidized form which has also been confirmed by a H18A mutant version of cyt c.	Histidine	4-13	cytochrome c, somatic	Homo sapiens	154-159
33175409-6	2021	The histidine (His-18) moiety close to hemin group is mainly responsible for proton abstraction to promote the concerted E2 pathway for KE catalysis when cyt c is in oxidized form which has also been confirmed by a H18A mutant version of cyt c.	Histidine	4-13	cytochrome c, somatic	Homo sapiens	238-243
33175409-6	2021	The histidine (His-18) moiety close to hemin group is mainly responsible for proton abstraction to promote the concerted E2 pathway for KE catalysis when cyt c is in oxidized form which has also been confirmed by a H18A mutant version of cyt c.	Histidine	15-18	cytochrome c, somatic	Homo sapiens	154-159
33175409-6	2021	The histidine (His-18) moiety close to hemin group is mainly responsible for proton abstraction to promote the concerted E2 pathway for KE catalysis when cyt c is in oxidized form which has also been confirmed by a H18A mutant version of cyt c.	Histidine	15-18	cytochrome c, somatic	Homo sapiens	238-243
33617675-2	2021	However, the motifs with histidine in the first three N-terminal positions (His1 , His2 , and His3 ) show unique Cu(II)-binding properties, such as availability from the surface of the protein, high flexibility, and high Cu(II) exchangeability with other ligands.	Histidine	25-34	histatin 3	Homo sapiens	83-87
33053185-7	2021	In particular, changes in L-histidine and homocarnosine correlated positively with level of CR and food anticipatory activity and negatively with insulin and body temperature.	Histidine	26-37	periphilin 1	Mus musculus	92-94
33625485-3	2021	Primary human umbilical vein endothelial cells (HUVECs) treated with a recombinant histidine-tagged sPRR (sPRR-His) exhibited IkappaBalpha degradation concurrent with NF-kappaB p65 activation.	Histidine	83-92	NFKB inhibitor alpha	Homo sapiens	126-138
33625414-8	2021	The interaction of the complexes with human transferrin (hTf) proteins was studied through molecular docking calculations, suggesting favorable binding through histidine residues and possible internalization into cancer cells via TfR-mediated endocytosis.	Histidine	160-169	transferrin	Homo sapiens	44-55
33672144-7	2021	Cystine and histidine were identified as best single markers for early stage OC/BOT and type I OC.	Histidine	12-21	bone gamma-carboxyglutamate protein	Homo sapiens	77-79
33576751-1	2021	Electrochemical and spectroscopic studies demonstrated that the N-truncated amyloid beta peptide Abeta5-9 (Arg-His-Asp-Ser-Gly-NH2) possessing histidine at position 2 (His-2) formed ternary complexes with copper(ii) and phosphate anions or phosphate groups of biomolecules.	Histidine	111-114	histatin 3	Homo sapiens	168-173
33576751-1	2021	Electrochemical and spectroscopic studies demonstrated that the N-truncated amyloid beta peptide Abeta5-9 (Arg-His-Asp-Ser-Gly-NH2) possessing histidine at position 2 (His-2) formed ternary complexes with copper(ii) and phosphate anions or phosphate groups of biomolecules.	Histidine	143-152	histatin 3	Homo sapiens	168-173
33639734-2	2021	In the present work, extensive atomistic molecular dynamics simulations were performed to investigate the hydration properties of aqueous solutions of concentrated arginine, histidine, and lysine and their comparative efficiency on regulating the conformational stability of the insulin monomer.	Histidine	174-183	insulin	Homo sapiens	279-286
33639734-6	2021	Importantly, it was observed that the preferentially more excluded arginine, compared to histidine and lysine from the insulin surface, enriches the hydration layer of the protein.	Histidine	89-98	insulin	Homo sapiens	119-126
33639734-7	2021	Our study reveals that the loss of configurational entropy of insulin in arginine solution, as compared to that in pure water, is more as compared to the entropy loss in the other two amino acid solutions, which, moreover, was found to be due to the presence of motionally bound less entropic hydration water of insulin in arginine solution than in histidine or lysine solution.	Histidine	349-358	insulin	Homo sapiens	62-69
33672144-9	2021	Between type II OC and BOTs, eight amino acids differed significantly and the highest AUC of 0.798 was achieved by histidine and citrulline (AUC of 0.778).	Histidine	115-124	bone gamma-carboxyglutamate protein	Homo sapiens	16-18
33672144-11	2021	Adding histidine to a multimarker panel together with CA125 and HE4 improved the differential diagnosis between OC and BOTs.	Histidine	7-16	bone gamma-carboxyglutamate protein	Homo sapiens	112-114
33576020-5	2021	We produced 6His-tagged recombinant human CYGB (His-CYGB), traced its bio-distribution and assessed its function in HSCs or in mice with advanced liver cirrhosis using thioacetamide (TAA) or 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC).	Histidine	13-16	cytoglobin	Homo sapiens	42-46
33554986-5	2021	It has been established experimentally that the binding of these drugs depends on the presence of one particular amino acid in the alpha1 subunit: histidine 102.	Histidine	147-156	BCL2 related protein A1	Homo sapiens	131-137
33576020-5	2021	We produced 6His-tagged recombinant human CYGB (His-CYGB), traced its bio-distribution and assessed its function in HSCs or in mice with advanced liver cirrhosis using thioacetamide (TAA) or 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC).	Histidine	13-16	cytoglobin	Homo sapiens	52-56
33576020-15	2021	CONCLUSIONS: His-CYGB could have anti-fibrotic clinical applications for human chronic liver diseases.	Histidine	13-16	cytoglobin	Homo sapiens	17-21
33152393-5	2021	In this study, to improve gene delivery efficiency, histidine and arginine were conjugated on the primary amines of PG2, synthesizing PG2HR.	Histidine	52-61	delta like non-canonical Notch ligand 1	Homo sapiens	116-119
33514426-7	2021	Our study also revealed that HLA-DRB1 amino acid at position 96 with histidine residue was negatively associated with the risk of developing ACPA-positive RA in the Indians (OR = 0.48, 95% CI = 0.37-0.62, PGWAS = 2.58 x 10-08).	Histidine	69-78	major histocompatibility complex, class II, DR beta 1	Homo sapiens	29-37
33278462-9	2021	All compounds investigated bound to the active site of SARS-CoV-2 Mpro, close to the catalytic dyad (His-41 and Cys-145).	Histidine	101-104	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	66-70
33449614-9	2021	The function of the histidine dyad in the HDAC10 mechanism appears to be similar to that in HDAC6, but not HDAC8 in which both functions are served by the second histidine of the tandem pair.	Histidine	20-29	histone deacetylase 6	Homo sapiens	92-97
33449614-9	2021	The function of the histidine dyad in the HDAC10 mechanism appears to be similar to that in HDAC6, but not HDAC8 in which both functions are served by the second histidine of the tandem pair.	Histidine	162-171	histone deacetylase 6	Homo sapiens	92-97
33350832-1	2021	The homodimeric myeloperoxidase (MPO) features a histidine as a proximal ligand and a sulfonium linkage covalently attaching the heme porphyrin ring to the protein.	Histidine	49-58	myeloperoxidase	Homo sapiens	16-31
33350832-1	2021	The homodimeric myeloperoxidase (MPO) features a histidine as a proximal ligand and a sulfonium linkage covalently attaching the heme porphyrin ring to the protein.	Histidine	49-58	myeloperoxidase	Homo sapiens	33-36
33521459-2	2021	CBS possesses a b-type heme coordinated by histidine and cysteine.	Histidine	43-52	cystathionine beta-synthase	Homo sapiens	0-3
33130280-7	2021	The catalytic triad consisting of Serine-441, Histidine-296 and Aspartic acid-345 was identified as active binding site of TMPRSS2 using existing ligands.	Histidine	46-55	transmembrane serine protease 2	Homo sapiens	123-130
33105479-5	2021	To gain insights into disease biology, we biochemically characterized missense variants within the conserved N-terminal aspartic acid-histidine-histidine (DHH) motif and provide evidence that they result in the destabilization of protein structure and/or loss of exopolyphosphatase activity.	Histidine	134-143	desert hedgehog signaling molecule	Homo sapiens	155-158
33105479-5	2021	To gain insights into disease biology, we biochemically characterized missense variants within the conserved N-terminal aspartic acid-histidine-histidine (DHH) motif and provide evidence that they result in the destabilization of protein structure and/or loss of exopolyphosphatase activity.	Histidine	144-153	desert hedgehog signaling molecule	Homo sapiens	155-158
33952823-0	2021	Protonation State of a Histidine Residue in Human Oligopeptide Transporter 1 (hPEPT1) Regulates hPEPT1-Mediated Efflux Activity.	Histidine	23-32	solute carrier family 15 member 1	Homo sapiens	78-84
33952823-0	2021	Protonation State of a Histidine Residue in Human Oligopeptide Transporter 1 (hPEPT1) Regulates hPEPT1-Mediated Efflux Activity.	Histidine	23-32	solute carrier family 15 member 1	Homo sapiens	96-102
33952823-10	2021	These data indicate that the efflux process of hPEPT1 is also regulated in a pH-dependent manner by the protonation state of a histidine residue located at or near the substrate recognition site facing the extracellular space.	Histidine	127-136	solute carrier family 15 member 1	Homo sapiens	47-53
33144263-2	2021	Cytoglobin has an E7 distal histidine (His81), which unlike related globins such as myoglobin and hemoglobin, is in equilibrium between a bound, hexacoordinate state and an unbound, pentacoordinate state.	Histidine	28-37	cytoglobin	Homo sapiens	0-10
32671530-8	2021	ICA reversed the HI-induced reduction in phosphorylated Akt and activation of cleaved caspase-3.	Histidine	17-19	thymoma viral proto-oncogene 1	Mus musculus	56-59
32564647-4	2021	To more effectively identify promising Nrf2 activators through the inhibition of Keap1-Nrf2 PPI, a homogeneous time-resolved fluorescence resonance energy transfer (TR-FRET) assay was developed in this work by indirectly labeling the Keap1 Kelch domain protein with Tb-anti-His antibody as the donor and using, as the acceptor, fluorescein isothiocyanate (FITC)-labeled 9mer Nrf2 peptide amide, the same fluorescent probe that was used in an earlier fluorescence polarization (FP) assay.	Histidine	274-277	NFE2 like bZIP transcription factor 2	Homo sapiens	39-43
33751430-1	2021	Here we describe a protocol for a one-step purification of a soluble form of human FAD synthase (isoform 2; hFADS2), overexpressed as a 6-His-tagged fusion protein in Escherichia coli, with a yield of about 15 mg from 1 L of transformed bacterial culture.Following a desalting procedure, the protein is obtained in its FAD-bound form (about 0.8 molecules of FAD per 1 protein monomer).	Histidine	138-141	fatty acid desaturase 2	Homo sapiens	108-114
32564647-4	2021	To more effectively identify promising Nrf2 activators through the inhibition of Keap1-Nrf2 PPI, a homogeneous time-resolved fluorescence resonance energy transfer (TR-FRET) assay was developed in this work by indirectly labeling the Keap1 Kelch domain protein with Tb-anti-His antibody as the donor and using, as the acceptor, fluorescein isothiocyanate (FITC)-labeled 9mer Nrf2 peptide amide, the same fluorescent probe that was used in an earlier fluorescence polarization (FP) assay.	Histidine	274-277	kelch like ECH associated protein 1	Homo sapiens	81-86
32564647-4	2021	To more effectively identify promising Nrf2 activators through the inhibition of Keap1-Nrf2 PPI, a homogeneous time-resolved fluorescence resonance energy transfer (TR-FRET) assay was developed in this work by indirectly labeling the Keap1 Kelch domain protein with Tb-anti-His antibody as the donor and using, as the acceptor, fluorescein isothiocyanate (FITC)-labeled 9mer Nrf2 peptide amide, the same fluorescent probe that was used in an earlier fluorescence polarization (FP) assay.	Histidine	274-277	kelch like ECH associated protein 1	Homo sapiens	234-239
33166460-1	2020	Bacterial tRNA-guanine transglycosylase (Tgt) is involved in the biosynthesis of the modified tRNA nucleoside queuosine present in the anticodon wobble position of tRNAs specific for aspartate, asparagine, histidine, and tyrosine.	Histidine	206-215	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	10-39
33382023-11	2020	Significant decrease in TMPRSS2-Fisetin and TMPRSS2-Nafamostat complex fluctuation occurred around His 41, Glu 44, Gly 136, Ser 186 in RMSF study.	Histidine	99-102	transmembrane serine protease 2	Homo sapiens	24-31
33382023-11	2020	Significant decrease in TMPRSS2-Fisetin and TMPRSS2-Nafamostat complex fluctuation occurred around His 41, Glu 44, Gly 136, Ser 186 in RMSF study.	Histidine	99-102	transmembrane serine protease 2	Homo sapiens	44-51
33093173-1	2020	The recent structural elucidation of ex vivo Drosophila Orb2 fibrils revealed a novel amyloid formed by interdigitated Gln and His residue side chains belonging to the prion-like domain.	Histidine	127-130	orb2	Drosophila melanogaster	56-60
32978260-3	2020	Human alpha2-macroglobulin-like protein 1 (A2ML1) is a monomeric protease inhibitor but has the hydroxyl reactivity-conveying histidine residue.	Histidine	126-135	alpha-2-macroglobulin like 1	Homo sapiens	6-41
32978260-3	2020	Human alpha2-macroglobulin-like protein 1 (A2ML1) is a monomeric protease inhibitor but has the hydroxyl reactivity-conveying histidine residue.	Histidine	126-135	alpha-2-macroglobulin like 1	Homo sapiens	43-48
33239759-5	2020	In contrast to GLP-1, the N-terminal histidine of GLP-2 penetrates into the receptor core with a unique orientation.	Histidine	37-46	glucagon	Homo sapiens	50-55
32698065-5	2020	We found that 0.13 M histidine, 1.64 M methionine, 0.33 M cysteine, and 0.34 M arginine in addition to the GSH/GSSG is the optimal condition for refolding of reteplase.	Histidine	21-30	plasminogen activator, tissue type	Homo sapiens	158-167
32948897-7	2020	RESULT: Overexpression of AGXT2 decreased circulating and muscle histidine-containing dipeptides (> 70% decrease; p < 0.05), while AGXT2 KO did not result in altered histidine-containing dipeptides levels.	Histidine	65-74	alanine--glyoxylate aminotransferase 2	Homo sapiens	26-31
33260771-11	2020	LIC11112, LIC20143, and LIC11037 have the serine protease domain with the conserved catalytic triad His-Asp-Ser.	Histidine	100-103	coagulation factor II, thrombin	Homo sapiens	42-57
33166460-1	2020	Bacterial tRNA-guanine transglycosylase (Tgt) is involved in the biosynthesis of the modified tRNA nucleoside queuosine present in the anticodon wobble position of tRNAs specific for aspartate, asparagine, histidine, and tyrosine.	Histidine	206-215	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	41-44
32736274-7	2020	Of the seven Mpro histidines, residues 41, 163, 164, and 246 are in stable H-bonded regions; metal ion binding to one or more of these residues could break up the H-bond network, thereby affecting protease function.	Histidine	18-28	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	13-17
33147961-0	2020	Protonation State of a Key Histidine Ligand in the Iron-Quinone Complex of Photosystem II as Revealed by Light-Induced ATR-FTIR Spectroscopy.	Histidine	27-36	ATR serine/threonine kinase	Homo sapiens	119-122
33052996-7	2020	The results show that the oxidative capacity of OH coordinated Cu(ii)Abeta is significantly lower than that of the free OH radical and that propagation toward Abeta Asp and His residues is favoured over Tyr residues.	Histidine	173-176	amyloid beta precursor protein	Homo sapiens	69-74
33079118-4	2020	We present an approach based on the stable immobilization of different arrestin-3 proteins (wild type, and two mutants, mutant X (arrestin-3 I386A) and mutant Y (arrestin-3 R393E)) via histidine tags on NTA(Ni2+)-coated sensors in a defined orientation.	Histidine	185-194	arrestin 3	Homo sapiens	71-81
33335661-4	2020	A salt bridge contact with Glu651 in IRE1alpha was then targeted to build in selectivity over BRaf which instead possesses a histidine in this position (His539).	Histidine	125-134	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	94-98
32298488-0	2020	TCRs with segment TRAV9-2 or a CDR3 histidine are overrepresented among nickel-specific CD4+ T cells.	Histidine	36-45	CD4 molecule	Homo sapiens	88-91
32725787-1	2020	HLA-A*31:72 has one nucleotide change from HLA-A*31:01:02:01 where Histidine (188) is changed to Arginine.	Histidine	67-76	major histocompatibility complex, class I, A	Homo sapiens	0-5
32725787-1	2020	HLA-A*31:72 has one nucleotide change from HLA-A*31:01:02:01 where Histidine (188) is changed to Arginine.	Histidine	67-76	major histocompatibility complex, class I, A	Homo sapiens	43-48
32945658-6	2020	The interactions inhibiting heme dissociation were then seen to be (i) either a direct or a water molecule mediated interaction between distal histidine and heme iron; and (ii) stacking between heme and the alphaCE1/betaCD1 phenylalanine residue.	Histidine	143-152	angiotensin I converting enzyme	Homo sapiens	207-223
32454110-4	2020	It is suggested that glycation of lysine residues on the structure of AChE could change the conformation of the active site (Trp-86 and His-447) in a way that the orientation of acetylcholine interrupted.	Histidine	136-139	acetylcholinesterase (Cartwright blood group)	Homo sapiens	70-74
32460437-4	2020	Bypassing ligand-induced release of the Notch intracellular domain (NICD) by transient transfection of SCLCs with the pAdlox/V5-His-NICD construct was shown to upregulate ErbB2/3.	Histidine	128-131	erb-b2 receptor tyrosine kinase 2	Homo sapiens	171-178
32860079-11	2020	In summary, our studies indicate that NME1 and NME2 are involved in TGF-beta1-induced HSC activation and CCl4-induced liver fibrosis, which may be mediated by histidine phosphorylation.	Histidine	159-168	transforming growth factor beta 1	Homo sapiens	68-77
32935088-5	2020	Surprisingly, in addition to the orthosteric site common to morphinan opiates, fentanyl can move deeper and bind mOR through hydrogen bonding with a conserved histidine H297, which has been shown to modulate mOR"s ligand affinity and pH dependence in mutagenesis experiments, but its precise role remains unclear.	Histidine	159-168	opioid receptor, mu 1	Mus musculus	113-116
32935088-5	2020	Surprisingly, in addition to the orthosteric site common to morphinan opiates, fentanyl can move deeper and bind mOR through hydrogen bonding with a conserved histidine H297, which has been shown to modulate mOR"s ligand affinity and pH dependence in mutagenesis experiments, but its precise role remains unclear.	Histidine	159-168	opioid receptor, mu 1	Mus musculus	208-211
32879443-6	2020	Moreover, the mutation of histidine 200 of JMJD8 (JMJD8-H200Q) disrupted its binding with AKT1 and increased interaction of SETDB1 and PDK1 with AKT1.	Histidine	26-35	AKT serine/threonine kinase 1	Homo sapiens	90-94
32879443-6	2020	Moreover, the mutation of histidine 200 of JMJD8 (JMJD8-H200Q) disrupted its binding with AKT1 and increased interaction of SETDB1 and PDK1 with AKT1.	Histidine	26-35	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	124-130
32879443-6	2020	Moreover, the mutation of histidine 200 of JMJD8 (JMJD8-H200Q) disrupted its binding with AKT1 and increased interaction of SETDB1 and PDK1 with AKT1.	Histidine	26-35	AKT serine/threonine kinase 1	Homo sapiens	145-149
32978815-4	2021	We thereby employed metal-histidine coordination to self-assemble the Kv1.3 inhibitor margatoxin (MgTx) to fluorescent quantum dots (QDMgTx) as a means to label cells in vivo and test changes in neuronal excitability and metabolism when delivered to the OB.	Histidine	26-35	potassium voltage-gated channel, shaker-related subfamily, member 3	Mus musculus	70-75
33029259-7	2020	Conclusions: Changes in Glu level measured by 1H-MRS were inversely correlated with those in EAAT2 and GluR2 protein levels following HI, and the results demonstrated that 1H-MRS can reflect the early changes of glutamatergic activity in vivo.	Histidine	134-136	solute carrier family 1 member 2	Homo sapiens	93-98
32730791-1	2020	Histidine state (protonated or delta or epsilon tautomer) has been considered the origin of abnormal misfolding and aggregation of beta-amyloid (Abeta).	Histidine	0-9	amyloid beta precursor protein	Homo sapiens	145-150
32598986-10	2020	Moreover, HHE and HNE induced extensive apo-SOD1 modifications, by forming Schiff bases or Michael adducts with Lys, His, and Cys residues.	Histidine	117-120	superoxide dismutase 1	Homo sapiens	44-48
32623092-5	2020	DNA sequence analysis of the BR receptor-1 (BRI-1) gene detected a single-nucleotide A > G substitution at the position 2612 in the kinase domain which resulted in the change of His (CAC) to Arg (CGC) at residue 857 in subdomain IV of the kinase domain of the respective polypeptide.	Histidine	178-181	BRI1	Hordeum vulgare	44-49
32839778-5	2020	Surprisingly, in addition to the orthosteric site common to morphinan opiates, fentanyl can move deeper and bind mOR through hydrogen bonding with a conserved histidine H297, which has been shown to modulate mOR"s ligand affinity and pH dependence in mutagenesis experiments, but its precise role remains unclear.	Histidine	159-168	opioid receptor, mu 1	Mus musculus	113-116
32839778-5	2020	Surprisingly, in addition to the orthosteric site common to morphinan opiates, fentanyl can move deeper and bind mOR through hydrogen bonding with a conserved histidine H297, which has been shown to modulate mOR"s ligand affinity and pH dependence in mutagenesis experiments, but its precise role remains unclear.	Histidine	159-168	opioid receptor, mu 1	Mus musculus	208-211
32567070-7	2020	Independent in silico-based designs of a peptide (AmyP53) and a monoclonal antibody (PMN310) converged to identify a histidine motif (H13/H14) that is critical for oligomer neutralization.	Histidine	117-126	H1.3 linker histone, cluster member	Homo sapiens	134-141
32913582-4	2020	Compared with mesophilic orthologues, the cold-adapted cytoglobins favor binding of exogenous ligands to the hexa-coordinated bis-histidyl species, a trait related to their higher rate constant for distal-His/heme-Fe dissociation relative to human cytoglobin.	Histidine	205-208	cytoglobin	Homo sapiens	55-65
32780017-3	2020	Rather, Sfh5 is a redox-active penta-coordinate high spin FeIII hemoprotein with an unusual heme-binding arrangement that involves a co-axial tyrosine/histidine coordination strategy and a complex electronic structure connecting the open shell iron d-orbitals with three aromatic ring systems.	Histidine	151-160	Sfh5p	Saccharomyces cerevisiae S288C	8-12
32658489-4	2020	The controversial and unprovable concept of aromaticity here enjoys being the agent that rationalizes the seemingly innocent role of histidine (His41 of Mpro).	Histidine	133-142	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	153-157
32567070-8	2020	This "histidine trick" can be viewed as the Achilles" heel of Abeta in the fight against AD.	Histidine	6-15	amyloid beta precursor protein	Homo sapiens	62-67
32428845-11	2020	It is the ring nitrogen of tryptophan in GPx, a histidine in GAPDH and OxyR and a threonine in Prx.	Histidine	48-57	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	61-66
32798388-3	2020	The overexpression plasmid pcDNA3.1(+)-His-CPEB4, silencing plasmid pPLK+Puro-CPEB4 shRNA were transfected into K562 cells by electroporation so as to change CPEB4.	Histidine	39-42	cytoplasmic polyadenylation element binding protein 4	Homo sapiens	43-48
32551634-2	2020	Mutation and histidine tautomerism are considered intrinsic origins in accumulation of Abeta.	Histidine	13-22	amyloid beta precursor protein	Homo sapiens	87-92
32180302-3	2020	In this study, we generated a peptidyl chloromethyl ketone (dansyl-FAPAL-CMK) that inhibited the hClpP subunit through alkylation of the catalytic His 122, which was detected by LC-MS.	Histidine	147-150	C-X-C motif chemokine ligand 9	Homo sapiens	73-76
32585093-6	2020	The results suggested that under physiological conditions, the moiety cis-VIVOL2 (L = pic-, dhp-) is bound by only one accessible side-chain protein residue that can be Asp, Glu, or His, while VIVOL+ (L = ma-, acac-) can interact with the two equatorial and axial sites.	Histidine	182-185	dihydropyrimidinase	Homo sapiens	92-95
32662333-7	2021	Mechanism of binding of these compounds to MPro is mainly provided by van der Waals interactions with the functionally important residues of the enzyme, such as His-41, Met-49, Cys-145, Met-165, and Gln-189 that play a role of the binding hot spots assisting the predicted molecules to effectively interact with the MPro active site.	Histidine	161-164	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	43-47
32662333-7	2021	Mechanism of binding of these compounds to MPro is mainly provided by van der Waals interactions with the functionally important residues of the enzyme, such as His-41, Met-49, Cys-145, Met-165, and Gln-189 that play a role of the binding hot spots assisting the predicted molecules to effectively interact with the MPro active site.	Histidine	161-164	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	316-320
32695286-1	2020	Objectives: The present study sought to evaluate the beneficial effects of histidine (His) on oxidative stress, tumor necrosis factor alpha (TNF-alpha), renal histological alterations and anti-oxidant enzymes gene expressions in type 2 diabetic rats.	Histidine	75-84	tumor necrosis factor	Rattus norvegicus	112-139
32212239-7	2020	This tight regulation of charge by SOD1 is attributed to the protonation of the bridging histidine upon copper reduction, yielding redox centers that are isoelectric at both oxidation states.	Histidine	89-98	superoxide dismutase 1	Homo sapiens	35-39
32371395-10	2020	Substitution of either conserved histidine compromised the ability of Sts-1 to suppress signaling pathways downstream of both the TCR and the Dectin-1 receptor.	Histidine	33-42	ubiquitin associated and SH3 domain containing B	Homo sapiens	70-75
32088192-4	2020	We hypothesized that rats exposed to hi-IFS develop atrial remodeling involving fibrosis and connexin 43, which we sought to evaluate.	Histidine	37-39	gap junction protein, alpha 1	Rattus norvegicus	93-104
32630528-1	2020	The coordination of zinc ions by histidine residues of amyloid-beta peptide (Abeta) plays a critical role in the zinc-induced Abeta aggregation implicated in Alzheimer"s disease (AD) pathogenesis.	Histidine	33-42	amyloid beta precursor protein	Homo sapiens	77-82
32630528-2	2020	The histidine to arginine substitution at position 6 of the Abeta sequence (H6R, English mutation) leads to an early onset of AD.	Histidine	4-13	amyloid beta precursor protein	Homo sapiens	60-65
32350111-7	2020	We demonstrate that unique BMP15 finger residues at this site (Arg-301, Gly-304, His-307, and Met-369) enable potent activation of the SMAD2/3 pathway.	Histidine	81-84	bone morphogenetic protein 15	Homo sapiens	27-32
32496192-4	2020	The structures of resting and desensitized channels reveal a reentrant loop at the amino terminus of ASIC1 that includes the highly conserved "His-Gly" (HG) motif.	Histidine	143-146	acid sensing ion channel subunit 1	Gallus gallus	101-106
32255544-10	2020	These results allow us to elucidate the effect of DEPC modification on amyloidogenity of human Abeta and to speculate about the role of His residues in these processes.	Histidine	136-139	amyloid beta precursor protein	Homo sapiens	95-100
32280214-8	2020	Results: The results showed that the nanobody VHHGPC3 had specific high-affinity binding to His-GPC3 antigen.	Histidine	92-95	glypican 3	Mus musculus	49-53
32472000-1	2020	E. coli expressed recombinant basic fibroblast growth factor (bFGF) with histidine-tag (bFGF-His) was immobilized onto the surface of a glass plate modified with a Ni(II)-chelated alkanethiol monolayer.	Histidine	73-82	fibroblast growth factor 2	Homo sapiens	30-60
32472000-1	2020	E. coli expressed recombinant basic fibroblast growth factor (bFGF) with histidine-tag (bFGF-His) was immobilized onto the surface of a glass plate modified with a Ni(II)-chelated alkanethiol monolayer.	Histidine	73-82	fibroblast growth factor 2	Homo sapiens	62-66
32472000-1	2020	E. coli expressed recombinant basic fibroblast growth factor (bFGF) with histidine-tag (bFGF-His) was immobilized onto the surface of a glass plate modified with a Ni(II)-chelated alkanethiol monolayer.	Histidine	93-96	fibroblast growth factor 2	Homo sapiens	30-60
32472000-1	2020	E. coli expressed recombinant basic fibroblast growth factor (bFGF) with histidine-tag (bFGF-His) was immobilized onto the surface of a glass plate modified with a Ni(II)-chelated alkanethiol monolayer.	Histidine	93-96	fibroblast growth factor 2	Homo sapiens	62-66
32472000-1	2020	E. coli expressed recombinant basic fibroblast growth factor (bFGF) with histidine-tag (bFGF-His) was immobilized onto the surface of a glass plate modified with a Ni(II)-chelated alkanethiol monolayer.	Histidine	93-96	fibroblast growth factor 2	Homo sapiens	88-92
32472000-5	2020	Immortalized human mesenchymal stromal cells (hMSCs) were cultured on the bFGF-His-immobilized surface to examine their proliferation.	Histidine	79-82	fibroblast growth factor 2	Homo sapiens	74-78
32212610-1	2020	In this manuscript it is shown that by exposing commonly used lipids for bio- membrane mimicking studies to a solution containing the histidine rich intrinsically disordered protein Histatin 5, a protein cushion spontaneously forms underneath the bilayer.	Histidine	134-143	histatin 3	Homo sapiens	182-192
32271168-2	2020	Here, we report the multifaceted therapeutic potential of histidine-tagged recombinant soluble (pro)renin receptor (sPRR), termed sPRR-His, in a mouse model of diet-induced obesity (DIO).	Histidine	58-67	ATPase, H+ transporting, lysosomal accessory protein 2	Mus musculus	87-114
32328082-7	2020	This strategy was tested successfully by generating a recombinant gene, BiP:p38:bdSUMO : His:hLIF, that produced human leukemia inhibitory factor (hLIF) fused to p38, a coat protein of the Turnip crinkle virus; the inclusion of p38 increased levels of protein expression.	Histidine	89-92	heat shock protein family A (Hsp70) member 5	Homo sapiens	72-75
32328082-7	2020	This strategy was tested successfully by generating a recombinant gene, BiP:p38:bdSUMO : His:hLIF, that produced human leukemia inhibitory factor (hLIF) fused to p38, a coat protein of the Turnip crinkle virus; the inclusion of p38 increased levels of protein expression.	Histidine	89-92	mitogen-activated protein kinase 14	Homo sapiens	76-79
32328082-7	2020	This strategy was tested successfully by generating a recombinant gene, BiP:p38:bdSUMO : His:hLIF, that produced human leukemia inhibitory factor (hLIF) fused to p38, a coat protein of the Turnip crinkle virus; the inclusion of p38 increased levels of protein expression.	Histidine	89-92	mitogen-activated protein kinase 14	Homo sapiens	162-165
32328082-7	2020	This strategy was tested successfully by generating a recombinant gene, BiP:p38:bdSUMO : His:hLIF, that produced human leukemia inhibitory factor (hLIF) fused to p38, a coat protein of the Turnip crinkle virus; the inclusion of p38 increased levels of protein expression.	Histidine	89-92	mitogen-activated protein kinase 14	Homo sapiens	162-165
32034402-7	2020	Mutagenesis of the three zinc-coordinating histidine residues resulted in a significant reduction in the zinc-binding affinity of SFPQ in solution and the zinc-induced cytoplasmic aggregation of SFPQ in cultured neurons.	Histidine	43-52	splicing factor proline and glutamine rich	Homo sapiens	130-134
32034402-7	2020	Mutagenesis of the three zinc-coordinating histidine residues resulted in a significant reduction in the zinc-binding affinity of SFPQ in solution and the zinc-induced cytoplasmic aggregation of SFPQ in cultured neurons.	Histidine	43-52	splicing factor proline and glutamine rich	Homo sapiens	195-199
32265297-5	2020	The OTUB1 protein had a pre-arranged catalytic site, with strong electrostatic interactions between the active-site residues His-265 and Asp-267.	Histidine	125-128	OTU deubiquitinase, ubiquitin aldehyde binding 1	Homo sapiens	4-9
32483417-10	2020	Among these amino acids, asparagine (Asn), phenylalanine (Phe), and histidine (His) promoted CRC cell survival under glucose starvation when JMJD2B was knocked down.	Histidine	68-77	lysine demethylase 4B	Homo sapiens	141-147
32483417-10	2020	Among these amino acids, asparagine (Asn), phenylalanine (Phe), and histidine (His) promoted CRC cell survival under glucose starvation when JMJD2B was knocked down.	Histidine	79-82	lysine demethylase 4B	Homo sapiens	141-147
32483417-11	2020	Mechanistically, downregulation of JMJD2B inhibited autophagy in CRC cells through epigenetic regulation of microtubule associated protein 1 light chain 3 beta (LC3B), and subsequently decreased intracellular amino acid (Asn, Phe, His) levels under glucose deprivation, thus suppressing the survival of CRC cells.	Histidine	231-234	lysine demethylase 4B	Homo sapiens	35-41
32340168-2	2020	However, it has recently been documented that a radical intermediate formed during carbon monoxide release from ruthenium (Ru)-based CORM (CORM-2) interacts with histidine and can inactivate bee phospholipase A2 activity.	Histidine	162-171	phospholipase A2 group IB	Homo sapiens	195-211
32276642-15	2020	Compared to DTA- mice, ELISA revealed significantly lower IL-10 and TGF-beta levels in both male and female DTA+ mice under both normal conditions and after HI (more pronounced).	Histidine	157-159	interleukin 10	Mus musculus	58-63
32155075-6	2020	A model antibody fragment crystallizable (Fc) region in solution with CoII-tannic acid complexes revealed that the solvent-exposed CoII can directly coordinate to the histidine-rich portion of the Fc region.	Histidine	167-176	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-74
32155075-6	2020	A model antibody fragment crystallizable (Fc) region in solution with CoII-tannic acid complexes revealed that the solvent-exposed CoII can directly coordinate to the histidine-rich portion of the Fc region.	Histidine	167-176	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-135
32209662-9	2020	TMEM189 proteins contain a conserved protein motif (pfam10520) with eight conserved histidines that is shared by an alternative type of plant desaturase but not by other mammalian proteins.	Histidine	84-94	plasmanylethanolamine desaturase 1	Homo sapiens	0-7
32231266-2	2020	We have applied a new LC-ICP MS-based approach for direct determination of Cu(II)-binding affinities of HSA, CP and alpha2M in the presence of competing Cu(II)-binding reference ligands including His.	Histidine	196-199	albumin	Homo sapiens	104-107
31957446-9	2020	The thrombin-cleaved PAR4 exhibited a 2-fold increase (p > 0.01) in t1/2 values observed for four histidine residues (His180, His229, His240, and His380), demonstrating that these regions have decreased solvent accessibility upon thrombin treatment.	Histidine	98-107	coagulation factor II, thrombin	Homo sapiens	4-12
32183428-11	2020	FAM84B conserves H23 and H35 but not C113 with both histidine residues residing within a highly conserved motif that FAM84B shares with HRASLS1-5.	Histidine	52-61	phospholipase A and acyltransferase 3	Mus musculus	136-145
32183204-11	2020	However, the NG2- and CD146-positive neovessels had significantly higher densities in the TOF-HIS group than in the TOF-IIS group.	Histidine	94-97	chondroitin sulfate proteoglycan 4	Homo sapiens	13-16
31630339-1	2020	Alzheimer"s disease (AD) is related to the anomalous binding that occurs between amyloid-beta peptide (Abeta) and copper ion, through imidazole ring of histidine (His), as stated in the literature.	Histidine	152-161	amyloid beta precursor protein	Homo sapiens	103-108
31630339-1	2020	Alzheimer"s disease (AD) is related to the anomalous binding that occurs between amyloid-beta peptide (Abeta) and copper ion, through imidazole ring of histidine (His), as stated in the literature.	Histidine	163-166	amyloid beta precursor protein	Homo sapiens	103-108
32219097-8	2020	Interestingly, oral administration of seven essential amino acids (EAAs; valine, leucine, isoleucine, lysine, phenylalanine, histidine, and tryptophan) to LPD mice, which can be a source of neurotransmitters, reversed those behavioral changes.	Histidine	125-134	acyl-CoA synthetase bubblegum family member 1	Mus musculus	155-158
32153736-2	2020	Previous studies have shown that gene-encoding human SLPI have successfully been expressed in Escherichia coli (E. coli) with a C-terminal poly-histidine tag (His-tag).	Histidine	159-162	secretory leukocyte peptidase inhibitor	Homo sapiens	53-57
31909745-2	2020	TRX from the extremely halophilic archaeon Halobacterium salinarum NRC-1 (HsTRX-A), which has the highest acidic residue content [(Asp + Glu)/(Arg + Lys + His) = 9.0] among known TRXs, was chosen to elucidate the catalytic mechanism and evolutionary characteristics associated with haloadaptation.	Histidine	155-158	thioredoxin family protein	Halobacterium salinarum NRC-1	0-3
32153736-4	2020	We hypothesized that a His-tag close to an active site SLPI domain may interfere with the inhibition activity of SLPIs.	Histidine	23-26	secretory leukocyte peptidase inhibitor	Homo sapiens	55-59
32153736-15	2020	Conclusion: The His-tag position on the C-terminal of SLPI reduced the inhibition activity of SLPI.	Histidine	16-19	secretory leukocyte peptidase inhibitor	Homo sapiens	54-58
32153736-15	2020	Conclusion: The His-tag position on the C-terminal of SLPI reduced the inhibition activity of SLPI.	Histidine	16-19	secretory leukocyte peptidase inhibitor	Homo sapiens	94-98
32238653-5	2020	PLGA-nanoparticles were modified with oligo histidine-tagged (6 x His-tagged) recombinant SubAB (SubAB-PLGA) through a pH-sensitive linkage, and their translocation to the ER in macrophage cell line J774.1 cells, effects on inducible NO synthase (iNOS), and levels of tumor necrosis factor (TNF)-alpha cytokine induced by lipopolysaccharide (LPS) were examined.	Histidine	44-53	nitric oxide synthase 2, inducible	Mus musculus	224-245
32238653-5	2020	PLGA-nanoparticles were modified with oligo histidine-tagged (6 x His-tagged) recombinant SubAB (SubAB-PLGA) through a pH-sensitive linkage, and their translocation to the ER in macrophage cell line J774.1 cells, effects on inducible NO synthase (iNOS), and levels of tumor necrosis factor (TNF)-alpha cytokine induced by lipopolysaccharide (LPS) were examined.	Histidine	44-53	nitric oxide synthase 2, inducible	Mus musculus	247-251
32238653-5	2020	PLGA-nanoparticles were modified with oligo histidine-tagged (6 x His-tagged) recombinant SubAB (SubAB-PLGA) through a pH-sensitive linkage, and their translocation to the ER in macrophage cell line J774.1 cells, effects on inducible NO synthase (iNOS), and levels of tumor necrosis factor (TNF)-alpha cytokine induced by lipopolysaccharide (LPS) were examined.	Histidine	44-53	tumor necrosis factor	Mus musculus	268-301
31679116-9	2020	Exposure of PLA2 to a Ru-based CORM in the presence of histidine-rich human albumin resulted in loss of inhibition of PLA2.	Histidine	55-64	phospholipase A2 group IB	Homo sapiens	12-16
33390398-8	2020	The mRNA levels of PPARgamma, LXRalpha, and AMPKalpha in the liver were also reduced by excess histidine intake.	Histidine	95-104	nuclear receptor subfamily 1, group H, member 3	Rattus norvegicus	30-38
32741898-3	2020	Among other genes related to histidine and histamine, the expression of the gene of histamine ammonia lyase (Hal) was exclusively mobilized by the three fibrates.	Histidine	29-38	histidine ammonia lyase	Rattus norvegicus	84-107
32741898-3	2020	Among other genes related to histidine and histamine, the expression of the gene of histamine ammonia lyase (Hal) was exclusively mobilized by the three fibrates.	Histidine	29-38	histidine ammonia lyase	Rattus norvegicus	109-112
31679116-9	2020	Exposure of PLA2 to a Ru-based CORM in the presence of histidine-rich human albumin resulted in loss of inhibition of PLA2.	Histidine	55-64	phospholipase A2 group IB	Homo sapiens	118-122
31679116-10	2020	Ru-based CORM likely inhibit bee venom PLA2 anticoagulant activity via formation of reactive Ru species that bind to histidine residues of the enzyme.	Histidine	117-126	phospholipase A2 group IB	Homo sapiens	39-43
31368448-3	2019	The resulting flexible sensors exhibit capability in detecting ascorbic acid (AA), hydrogen peroxide (H2O2) and L-Histidine (L-His) with detection limits of 2.94, 4.1 and 5.3 muM, respectively.	Histidine	112-123	latexin	Homo sapiens	175-178
30686053-7	2019	l-histidine imprinted QCM biosensors was also used for RNAase, lysozyme, cytochrome-C and BSA to investigate the competitive adsorption of surface histidine exposed proteins.	Histidine	0-11	lysozyme	Homo sapiens	63-71
30686053-7	2019	l-histidine imprinted QCM biosensors was also used for RNAase, lysozyme, cytochrome-C and BSA to investigate the competitive adsorption of surface histidine exposed proteins.	Histidine	2-11	lysozyme	Homo sapiens	63-71
31566366-0	2019	Structural and Binding Properties on Abeta Mature Fibrils Due to the Histidine Tautomeric Effect.	Histidine	69-78	abeta	None	37-42
31566366-4	2019	Our results show that substituting chain 1 with different histidine states affects Abeta structural properties in A2, D7-G9, H14-Q15, S26-N27, and G33-G37 regions.	Histidine	58-67	abeta	None	83-88
31187393-5	2019	These studies have shown that SELENOK interacts with an enzyme in the ER membrane, DHHC6 (letters represent the amino acids aspartic acid, histidine, histidine, and cysteine in the catalytic domain), and the SELENOK/DHHC6 complex catalyzes the transfer of acyl groups such as palmitate to cysteine residues in target proteins, i.e., palmitoylation.	Histidine	139-148	selenoprotein K	Mus musculus	30-37
31187393-5	2019	These studies have shown that SELENOK interacts with an enzyme in the ER membrane, DHHC6 (letters represent the amino acids aspartic acid, histidine, histidine, and cysteine in the catalytic domain), and the SELENOK/DHHC6 complex catalyzes the transfer of acyl groups such as palmitate to cysteine residues in target proteins, i.e., palmitoylation.	Histidine	139-148	zinc finger, DHHC domain containing 6	Mus musculus	83-88
31187393-5	2019	These studies have shown that SELENOK interacts with an enzyme in the ER membrane, DHHC6 (letters represent the amino acids aspartic acid, histidine, histidine, and cysteine in the catalytic domain), and the SELENOK/DHHC6 complex catalyzes the transfer of acyl groups such as palmitate to cysteine residues in target proteins, i.e., palmitoylation.	Histidine	139-148	selenoprotein K	Mus musculus	208-215
31187393-5	2019	These studies have shown that SELENOK interacts with an enzyme in the ER membrane, DHHC6 (letters represent the amino acids aspartic acid, histidine, histidine, and cysteine in the catalytic domain), and the SELENOK/DHHC6 complex catalyzes the transfer of acyl groups such as palmitate to cysteine residues in target proteins, i.e., palmitoylation.	Histidine	139-148	zinc finger, DHHC domain containing 6	Mus musculus	216-221
31187393-5	2019	These studies have shown that SELENOK interacts with an enzyme in the ER membrane, DHHC6 (letters represent the amino acids aspartic acid, histidine, histidine, and cysteine in the catalytic domain), and the SELENOK/DHHC6 complex catalyzes the transfer of acyl groups such as palmitate to cysteine residues in target proteins, i.e., palmitoylation.	Histidine	150-159	selenoprotein K	Mus musculus	30-37
31187393-5	2019	These studies have shown that SELENOK interacts with an enzyme in the ER membrane, DHHC6 (letters represent the amino acids aspartic acid, histidine, histidine, and cysteine in the catalytic domain), and the SELENOK/DHHC6 complex catalyzes the transfer of acyl groups such as palmitate to cysteine residues in target proteins, i.e., palmitoylation.	Histidine	150-159	zinc finger, DHHC domain containing 6	Mus musculus	83-88
31187393-5	2019	These studies have shown that SELENOK interacts with an enzyme in the ER membrane, DHHC6 (letters represent the amino acids aspartic acid, histidine, histidine, and cysteine in the catalytic domain), and the SELENOK/DHHC6 complex catalyzes the transfer of acyl groups such as palmitate to cysteine residues in target proteins, i.e., palmitoylation.	Histidine	150-159	selenoprotein K	Mus musculus	208-215
31187393-5	2019	These studies have shown that SELENOK interacts with an enzyme in the ER membrane, DHHC6 (letters represent the amino acids aspartic acid, histidine, histidine, and cysteine in the catalytic domain), and the SELENOK/DHHC6 complex catalyzes the transfer of acyl groups such as palmitate to cysteine residues in target proteins, i.e., palmitoylation.	Histidine	150-159	zinc finger, DHHC domain containing 6	Mus musculus	216-221
31335975-5	2019	Using ELISA and tryptophan fluorescence binding studies we observed that the soluble histidine-tagged CD93-CTLD was specifically binding to CpG ODN and bacterial DNA.	Histidine	85-94	CD93 molecule	Homo sapiens	102-106
31441974-1	2019	A calix[4]arene ligand, in which two of the phenol functions are replaced by pyrazole units has been employed to mimic the His2 -Tyr2 (His: histidine, Tyr: tyrosine) ligand sphere within the active site of the galactose oxidase (GO).	Histidine	140-149	histatin 3	Homo sapiens	123-127
31658742-7	2019	Iron and copper were coordinated by the same N-terminal region of Abeta, likely through histidine residues.	Histidine	88-97	amyloid beta precursor protein	Homo sapiens	66-71
31475275-2	2019	In an attempt to understand the impact of the coordination of Zn(ii) and Cu(ii) on the biological activity of calcitermin, we mutated each of the histidines with an alanine and studied the thermodynamics, binding mode and antimicrobial activity of wild type calcitermin and its H9A, H11A and H13A mutants and their Zn(ii) and Cu(ii) complexes.	Histidine	146-156	S100 calcium binding protein A12	Homo sapiens	110-121
31469551-6	2019	Substitution of Arg-513 with histidine (the equivalent residue in COX-1) resulted in a 2-fold potentiation of aspirin inhibition, in support of the hypothesis that the presence of histidine in COX-1 lowers the activation barrier associated with the formation of the initial noncovalent enzyme-inhibitor complex.	Histidine	29-38	cytochrome c oxidase I, mitochondrial	Mus musculus	66-71
31469551-6	2019	Substitution of Arg-513 with histidine (the equivalent residue in COX-1) resulted in a 2-fold potentiation of aspirin inhibition, in support of the hypothesis that the presence of histidine in COX-1 lowers the activation barrier associated with the formation of the initial noncovalent enzyme-inhibitor complex.	Histidine	29-38	cytochrome c oxidase I, mitochondrial	Mus musculus	193-198
31382568-6	2019	The brain permeable histamine precursor histidine was chronically administered to symptomatic SOD1-G93A mice.	Histidine	40-49	superoxide dismutase 1, soluble	Mus musculus	94-98
31524265-9	2019	GO and KEGG analyses revealed that differentially expressed mRNAs regulated asthma by participating in the "vascular endothelial (VEGF) signaling pathway", "oxidative phosphorylation", "Fc epsilon RI signaling pathway", "amino sugar and nucleotide sugar metabolism", "histidine metabolism", "beta-alanine metabolism" and "extracellular matrix-receptor interaction" (P&lt;0.05).	Histidine	268-277	vascular endothelial growth factor A	Homo sapiens	130-134
31466283-4	2019	We show that this cDNA is functional and expresses neurofibromin, His-Tag, and can correct p-ERK/ERK ratios in NF1 null HEK293 cells.	Histidine	66-69	neurofibromin 1	Homo sapiens	111-114
33455163-4	2019	In this study, we uncover the interaction between an angiopoietin-1 mimetic peptide, QHREDGS (glutamine-histidine-arginine-glutamic acid-aspartic acid-glycine-serine), immobilized to a collagen-chitosan hydrogel, and murine bone marrow derived macrophages.	Histidine	104-113	angiopoietin 1	Mus musculus	53-67
31412042-4	2019	RESULTS: The best correlations of Alb were with tryptophan (Trp) and histidine (His) (r = + 0.53; p < 0.0001), and those of Hb were with histidine (r = +0.47) and Essential AAs (r = +0.47) (both p<0.0001).	Histidine	69-78	albumin	Homo sapiens	34-37
31412042-4	2019	RESULTS: The best correlations of Alb were with tryptophan (Trp) and histidine (His) (r = + 0.53; p < 0.0001), and those of Hb were with histidine (r = +0.47) and Essential AAs (r = +0.47) (both p<0.0001).	Histidine	80-83	albumin	Homo sapiens	34-37
31382568-7	2019	Spine density was measured by Golgi-staining in motor cortex of histidine-treated SOD1-G93A mice.	Histidine	64-73	superoxide dismutase 1, soluble	Mus musculus	82-86
31382568-9	2019	In SOD1-G93A mice, histidine augments the protein content of GRP78 and Hsp70 in spinal cord and cortex, where the treatment also rescues type I motor neuron dendritic spine loss.	Histidine	19-28	superoxide dismutase 1, soluble	Mus musculus	3-7
31382568-9	2019	In SOD1-G93A mice, histidine augments the protein content of GRP78 and Hsp70 in spinal cord and cortex, where the treatment also rescues type I motor neuron dendritic spine loss.	Histidine	19-28	heat shock protein 5	Mus musculus	61-66
31382568-9	2019	In SOD1-G93A mice, histidine augments the protein content of GRP78 and Hsp70 in spinal cord and cortex, where the treatment also rescues type I motor neuron dendritic spine loss.	Histidine	19-28	heat shock protein 1B	Mus musculus	71-76
32184956-1	2020	The melanocortin receptors are stimulated by agonists (alpha-MSH, beta-MSH, gamma-MSH, and ACTH) processed from the proopiomelanocortin (POMC) gene transcript and possess a common His-Phe-Arg-Trp tetrapeptide sequence critical for receptor activation.	Histidine	180-183	proopiomelanocortin	Homo sapiens	91-95
31150637-3	2019	Positively charged arginine (R) and histidine (H) of mouse AQP0 ELA and ELC were substituted individually with glutamine (Q) to create R33Q, H40Q, R113Q and H122Q by mutagenesis.	Histidine	36-45	major intrinsic protein of lens fiber	Mus musculus	59-63
31020811-9	2019	Histidine treatment in SOD1-G93A mice proved broad efficacy in ameliorating ALS features, among which most importantly lifespan, motor performance, microgliosis, muscle atrophy, and motor neurons survival in vivo and in vitro.	Histidine	0-9	superoxide dismutase 1, soluble	Mus musculus	23-27
30779238-6	2019	Spectral data indicate that this cascade of events proceeds through formation of phenoxyl radical via proton-coupled electron transport (PCET) between OH group of p-NP and imidazole ring of histidine from the protein.	Histidine	190-199	purine nucleoside phosphorylase	Homo sapiens	163-167
32184956-3	2020	Herein, 12 single nucleotide polymorphisms (SNPs) deposited into the Variation Viewer database within the His-Phe-Arg-Trp sequences of ACTH/alpha-MSH, beta-MSH, and gamma-MSH were substituted into tetrapeptide scaffolds to examine the in vitro signaling effects of these polymorphisms at the cloned melanocortin receptors.	Histidine	106-109	proopiomelanocortin	Homo sapiens	135-139
32184956-3	2020	Herein, 12 single nucleotide polymorphisms (SNPs) deposited into the Variation Viewer database within the His-Phe-Arg-Trp sequences of ACTH/alpha-MSH, beta-MSH, and gamma-MSH were substituted into tetrapeptide scaffolds to examine the in vitro signaling effects of these polymorphisms at the cloned melanocortin receptors.	Histidine	106-109	STAM binding protein	Homo sapiens	140-149
31273433-4	2019	We show here that the SLC30A8 gene is also inactivated in sheep, cows, chinchillas and naked mole rats but in all four species a histidine is retained at amino acid 10 in the B chain of insulin.	Histidine	129-138	insulin	Heterocephalus glaber	186-193
31489168-5	2019	These show the peptide is trimeric and binds to both Cu(ii) and Ni(ii) in a 1 : 1 ratio with the histidine residues involved in the metal coordination, as designed.	Histidine	97-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-58
30972949-10	2019	Dovetail Chicago and Hi-C libraries increased the longest scaffold over 12-fold, from 9.71 Mbp to 124.99 Mbp and the scaffold N50 over 50-fold, from 1.48 Mbp to 75.02 Mbp.	Histidine	21-24	myelin basic protein	Camelus dromedarius	91-94
30972949-10	2019	Dovetail Chicago and Hi-C libraries increased the longest scaffold over 12-fold, from 9.71 Mbp to 124.99 Mbp and the scaffold N50 over 50-fold, from 1.48 Mbp to 75.02 Mbp.	Histidine	21-24	myelin basic protein	Camelus dromedarius	105-108
30972949-10	2019	Dovetail Chicago and Hi-C libraries increased the longest scaffold over 12-fold, from 9.71 Mbp to 124.99 Mbp and the scaffold N50 over 50-fold, from 1.48 Mbp to 75.02 Mbp.	Histidine	21-24	myelin basic protein	Camelus dromedarius	105-108
30972949-10	2019	Dovetail Chicago and Hi-C libraries increased the longest scaffold over 12-fold, from 9.71 Mbp to 124.99 Mbp and the scaffold N50 over 50-fold, from 1.48 Mbp to 75.02 Mbp.	Histidine	21-24	myelin basic protein	Camelus dromedarius	105-108
31082440-6	2019	15N NMR spectra indicate that removal of the second histidine converted the protonation and tautomeric equilibria of H19 to be similar to the H37 behavior in AM2, indicating that the peripheral H27 is indeed the origin of the low pKa"s of H19 in wild-type BM2.	Histidine	52-61	RNA binding motif protein 5	Homo sapiens	142-145
31489168-5	2019	These show the peptide is trimeric and binds to both Cu(ii) and Ni(ii) in a 1 : 1 ratio with the histidine residues involved in the metal coordination, as designed.	Histidine	97-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-69
30663929-1	2019	We recently reported that the cyclin T1 histidine-rich domain creates a phase-separated environment to promote hyperphosphorylation of RNA polymerase II C-terminal domain and robust transcriptional elongation by P-TEFb.	Histidine	40-49	cyclin T1	Homo sapiens	30-39
30937948-9	2019	Genes CTNND2 (catenin delta 2), APOB (apolipoprotein B), FHIT (fragile histidine triad) and ESRRG (estrogen related receptor gamma) were identified in at least two GWASes.	Histidine	71-80	bis(5'-adenosyl)-triphosphatase	Bubalus bubalis	57-61
30991141-5	2019	Akt activation, iNOS induction, and viability loss in PDT-challenged glioblastoma U87 cells were all strongly inhibited by added l-histidine, consistent with primary involvement of photogenerated singlet oxygen (1O2).	Histidine	129-140	AKT serine/threonine kinase 1	Homo sapiens	0-3
30991141-5	2019	Akt activation, iNOS induction, and viability loss in PDT-challenged glioblastoma U87 cells were all strongly inhibited by added l-histidine, consistent with primary involvement of photogenerated singlet oxygen (1O2).	Histidine	129-140	nitric oxide synthase 2	Homo sapiens	16-20
30047851-1	2019	The present study was designed to investigate the influence of two indispensable and two dispensable amino acids, including methionine, histidine, cysteine and proline, on the binding interaction between human serum albumin (HSA) and an antibiotic agent lomefloxacin (LMF).	Histidine	136-145	albumin	Homo sapiens	210-223
30813720-1	2019	As the intrinsic origin of the hypothesis for beta-amyloid (Abeta) from Alzheimer"s disease, histidine behaviors were found to play a crucial role in Abeta aggregation.	Histidine	93-102	amyloid beta precursor protein	Homo sapiens	46-66
31127106-2	2019	External perturbations such as pH and hydrogen bonding can also trigger the spin state transition of hemes through deprotonated histidine (e.g. Cytochrome c).	Histidine	128-137	cytochrome c, somatic	Homo sapiens	144-156
30753862-0	2019	Histidine and arginine modulate intestinal cell restitution via transforming growth factor-beta1.	Histidine	0-9	transforming growth factor, beta 1	Rattus norvegicus	64-96
31013069-4	2019	In isolated plaque cores, Cu(II) is bound to Abeta via histidine residues.	Histidine	55-64	amyloid beta precursor protein	Homo sapiens	45-50
30753862-10	2019	Supplementation of 10 microM histidine to DeltaHis or 50 microM arginine to DeltaArg recovered the decreases in both cell restitution and TGF-beta1 extracellular concentration.	Histidine	29-38	transforming growth factor, beta 1	Rattus norvegicus	138-147
30753862-13	2019	The present findings suggested that deletion of histidine or arginine led to a decrease in IEC restitution through a decrease in TGF-beta1.	Histidine	48-57	transforming growth factor, beta 1	Rattus norvegicus	129-138
30626284-5	2019	We also determined X-ray crystal structures of BCL2 and BCL2L1 with T108-modified BECN1 BH3 peptides, but only showed evidence of an interaction between the BH3 peptide and the conserved histidine residue when the histidine flexibility was restrained due to crystal contacts.	Histidine	187-196	BCL2 apoptosis regulator	Homo sapiens	47-51
30863889-9	2019	In addition, we also examined the expression of pyruvate dehydrogenase kinase 4 mRNA, which was comparably influenced by L-histidine and carnosine, but did not correlate with effects on viability.	Histidine	121-132	pyruvate dehydrogenase kinase 4	Homo sapiens	48-79
30830753-5	2019	Therefore, we hypothesized that Zn2+ would inhibit LPLA2 activity at a neutral but not acidic pH because histidine would be positively charged at lower pH.	Histidine	105-114	phospholipase A2 group XV	Homo sapiens	51-56
30771375-2	2019	Despite the important role of histidine in stabilizing the fibrillar structure of the Abeta peptide at neutral pH, the effect of histidine tautomerism on Abeta peptide aggregation is still largely unknown.	Histidine	30-39	amyloid beta precursor protein	Homo sapiens	86-91
30771375-2	2019	Despite the important role of histidine in stabilizing the fibrillar structure of the Abeta peptide at neutral pH, the effect of histidine tautomerism on Abeta peptide aggregation is still largely unknown.	Histidine	129-138	amyloid beta precursor protein	Homo sapiens	154-159
30771375-3	2019	Histidine is in equilibrium between delta and epsilon tautomers and there are three histidine residues (H6, H13, and H14) in the Abeta(1-40) peptide.	Histidine	84-93	H1.3 linker histone, cluster member	Homo sapiens	108-111
31080350-13	2019	Our results suggest that the three residues, Lys-554, His-594, and Glu-598, in TRPC5 might be responsible for direct interaction with EA, inducing the channel activation.	Histidine	54-57	transient receptor potential cation channel subfamily C member 5	Homo sapiens	79-84
29964304-9	2019	CONCLUSIONS: Specificity and fragmentation analysis provides crucial information for the analysis of chemically modified cysteines and histidines by MALDI-MS. Elucidation of binding sites by MALDI-MS has been significantly improved using an easy-to-run peptide assay and gives background information for the analysis in the case of chemically modified 5-lipoxygenase.	Histidine	135-145	arachidonate 5-lipoxygenase	Homo sapiens	352-366
30772266-3	2019	We hypothesize that the enzyme responsible for (d)NMPS catabolism could be Hint1, an enzyme that belongs to the histidine triad (HIT) superfamily and is present in all organisms.	Histidine	112-121	histidine triad nucleotide binding protein 1	Homo sapiens	75-80
30802707-5	2019	Molecular modeling revealed that the compound 4d binds through hydrophobic-hydrophobic interactions with the essential amino acids (LEU: 57, GLY: 58, ILE: 61, and HIS: 96) in the p53-binding cleft, as a standard p53-MDM2 inhibitor (6SJ).	Histidine	163-166	tumor protein p53	Homo sapiens	179-182
30912641-1	2019	Protein histidine phosphorylation plays a vital role in cell signaling and metabolic processes, and phosphohistidine (pHis) phosphatases such as protein histidine phosphatase 1 (PHPT1) and LHPP have been linked to cancer and diabetes, making them novel drug targets and biomarkers.	Histidine	8-17	phosphohistidine phosphatase 1	Homo sapiens	178-183
30912641-1	2019	Protein histidine phosphorylation plays a vital role in cell signaling and metabolic processes, and phosphohistidine (pHis) phosphatases such as protein histidine phosphatase 1 (PHPT1) and LHPP have been linked to cancer and diabetes, making them novel drug targets and biomarkers.	Histidine	8-17	phospholysine phosphohistidine inorganic pyrophosphate phosphatase	Homo sapiens	189-193
30839985-2	2019	Here we report the design and syntheses of a novel class of histidine-containing hexapeptide derivatives (Nap-1 and ID-1) for in situ hydrogelation at the zinc ion-rich prostate tissue.	Histidine	60-69	nucleosome assembly protein 1 like 1	Homo sapiens	106-111
30284207-2	2019	A bacterial expression system was used to produce human recombinant manganese SOD with a His-tag on the C-end of the protein for better purification.	Histidine	89-92	superoxide dismutase 1	Homo sapiens	78-81
30893314-10	2019	FTCD is critical for catabolism of histidine, a process that generates one-carbon units that can enter the one-carbon/folate cycle, which provides methyl groups for arsenic metabolism.	Histidine	35-44	formimidoyltransferase cyclodeaminase	Homo sapiens	0-4
30804004-2	2019	Here, we use Drosophila cancer models to show that decreasing the concentration of histidine in the diet strongly inhibits the growth of mutant clones induced by loss of Nerfin-1 or gain of Notch activity.	Histidine	83-92	nervous fingers 1	Drosophila melanogaster	170-178
30804004-5	2019	We demonstrate that Myc overexpression in nerfin-1 tumours is sufficient to switch their mode of growth from histidine/Hdc sensitive to resistant.	Histidine	109-118	nervous fingers 1	Drosophila melanogaster	42-50
30839985-3	2019	Thanks to the efficient co-ordination between zinc and histidine, both Nap-1 and ID-1 displayed excellent self-assembly capability with a high sensitivity to zinc ions at ~0.1 equivalency.	Histidine	55-64	nucleosome assembly protein 1 like 1	Homo sapiens	71-76
30461096-8	2019	This approach was applied to Src mutant libraries randomized in the highly conserved HRD motif in the catalytic loop, and revealed that structurally diverse residues can replace the His and Arg residues, while the Asp residue is irreplaceable for catalytic activity.	Histidine	182-185	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	29-32
30694660-6	2019	To this end, we studied the impact of widely used histidine to alanine mutations in amyloid-beta (Abeta).	Histidine	50-59	amyloid beta precursor protein	Homo sapiens	84-96
30668110-4	2019	TRAIL bound to PVX by coordination bonds between nickel-coordinated nitrilotriacetic acid on PVX and His-tag on the protein could mimic the bioactive "membrane-bound" state in native TRAIL, resulting in an elongated nanoparticle displaying up 490 therapeutic protein molecules.	Histidine	101-104	TNF superfamily member 10	Homo sapiens	0-5
30668110-4	2019	TRAIL bound to PVX by coordination bonds between nickel-coordinated nitrilotriacetic acid on PVX and His-tag on the protein could mimic the bioactive "membrane-bound" state in native TRAIL, resulting in an elongated nanoparticle displaying up 490 therapeutic protein molecules.	Histidine	101-104	TNF superfamily member 10	Homo sapiens	183-188
30694660-7	2019	We found that the secondary and tertiary contacts, salt bridge formations, and thermodynamic properties, as well as disorder propensities and aggregation predisposition of Abeta, are impacted by the single and triple point histidine to alanine mutations.	Histidine	223-232	amyloid beta precursor protein	Homo sapiens	172-177
30481537-4	2019	l-Phe-d-His-l-Leu was custom-designed by changing the configuration of penultimate amino acid residue (histidine) from C-terminal of Ang I, the site at which ACE acts upon and generates Ang II.	Histidine	103-112	angiotensin I converting enzyme	Rattus norvegicus	158-161
30823619-7	2019	As indicated by relevance networking, isoleucine, lysine, valine, histidine, and ornithine were the most discriminant for high RFI, whereas 3 biogenic amines (carnosine, putrescine, and spermidine) and 3 diacyl-glycerophospholipids (38:4, 38:5, and 40:5) positively correlated with feed intake and body weight gain, respectively.	Histidine	66-75	RFI	Gallus gallus	127-130
30723194-4	2019	High-resolution crystal structures of Zn2+-bound ERp44 reveal that Zn2+ binds to a conserved histidine-cluster.	Histidine	93-102	endoplasmic reticulum protein 44	Homo sapiens	49-54
30723194-7	2019	Histidine mutations in the Zn2+-binding sites compromise ERp44 activity and localization.	Histidine	0-9	endoplasmic reticulum protein 44	Homo sapiens	57-62
30622225-1	2019	Histidine triad nucleotide-binding protein (HINT) is a member of the histidine triad (HIT) superfamily, which has hydrolase activity owing to a histidine triad motif.	Histidine	69-78	histidine triad nucleotide binding protein 1	Homo sapiens	0-42
30622225-1	2019	Histidine triad nucleotide-binding protein (HINT) is a member of the histidine triad (HIT) superfamily, which has hydrolase activity owing to a histidine triad motif.	Histidine	69-78	histidine triad nucleotide binding protein 1	Homo sapiens	44-48
30622225-1	2019	Histidine triad nucleotide-binding protein (HINT) is a member of the histidine triad (HIT) superfamily, which has hydrolase activity owing to a histidine triad motif.	Histidine	144-153	histidine triad nucleotide binding protein 1	Homo sapiens	0-42
30622225-1	2019	Histidine triad nucleotide-binding protein (HINT) is a member of the histidine triad (HIT) superfamily, which has hydrolase activity owing to a histidine triad motif.	Histidine	144-153	histidine triad nucleotide binding protein 1	Homo sapiens	44-48
31091472-2	2019	The structure and enzymology of NQO1 is well-characterised, showing a substituted enzyme mechanism in which NAD(P)H binds first and reduces an FAD cofactor in the active site, assisted by a charge relay system involving Tyr-155 and His-161.	Histidine	232-235	NAD(P)H quinone dehydrogenase 1	Homo sapiens	32-36
30554660-5	2019	GST-SSL5 was found to attenuate the inhibitory activity of recombinant histidine-tagged C1Inh (C1Inh-His) toward complement C1s.	Histidine	71-80	complement C1s	Homo sapiens	124-127
30697165-4	2018	Both necroptosis inhibitors of RIPK1 and RIPK3 and a necroptosis activator/apoptosis inhibitor z-VAD increased cell death caused by L-histidine, but not L-arginine or L-ornithine.	Histidine	132-143	receptor (TNFRSF)-interacting serine-threonine kinase 1	Mus musculus	31-36
30697165-5	2018	Cyclophilin D knock-out (Ppif-/-) significantly attenuated cell death induced by L-histidine, but not L-arginine, or L-ornithine.	Histidine	81-92	peptidylprolyl isomerase F (cyclophilin F)	Mus musculus	0-13
30697165-5	2018	Cyclophilin D knock-out (Ppif-/-) significantly attenuated cell death induced by L-histidine, but not L-arginine, or L-ornithine.	Histidine	81-92	peptidylprolyl isomerase F (cyclophilin F)	Mus musculus	25-29
30697165-7	2018	We developed a novel amino acid-induced AP murine model with high doses of L-histidine and confirmed AP severity was significantly reduced in Ppif-/- vs. wild type mice.	Histidine	75-86	peptidylprolyl isomerase F (cyclophilin F)	Mus musculus	142-146
30311076-4	2019	His-p24 was the most suitable antigen for using in the ELISA.	Histidine	0-3	transmembrane p24 trafficking protein 2	Homo sapiens	4-7
30617637-2	2019	For the effective transfection of p11 gene intracellularly, two cationic lipids based on phospholipid DOPE conjugated to basic amino acids histidine and arginine were synthesised, used for liposome formulation and evaluated for their ability as gene delivery vectors.	Histidine	139-148	S100 calcium binding protein A10	Homo sapiens	34-37
30607513-2	2019	The mutation is located in the activation loop (A-loop) region of the c-Met kinase domain, which substitutes the negatively charged residue Asp1228 with electroneutral amino acid Val, His, or Asn, thus electrostatically destabilizing the DFG-in conformation of A-loop and inducing its transition to DFG-out state.	Histidine	184-187	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	70-75
32440368-3	2019	Serum histidine is also inversely correlated with proinflammatory cytokines (e.g., TNF, IFN-y), which have been linked to MS fatigue.	Histidine	6-15	tumor necrosis factor	Homo sapiens	83-86
32440368-3	2019	Serum histidine is also inversely correlated with proinflammatory cytokines (e.g., TNF, IFN-y), which have been linked to MS fatigue.	Histidine	6-15	interferon gamma	Homo sapiens	88-93
32440368-9	2019	Gene expression of TNF correlated with histidine only in people with normal fatigue (r = .51, p = .034), while no other cytokines related to histidine levels.	Histidine	39-48	tumor necrosis factor	Homo sapiens	19-22
30547569-5	2018	We chose a set of mutations to examine conserved Asp and Glu residues in the hydrolase active sites, as well as the ligation sphere around the catalytic calcium and a His-His dyad seen in PON1.	Histidine	167-170	paraoxonase 1	Homo sapiens	188-192
30453113-4	2019	Here, we analysis the structural effects of 4-HNE modification through formation of Michael adducts of Cys-4HNE, His-4HNE and Lys-4HNE on Serum Albumin (BSA) and Thioredoxin (TRX).	Histidine	113-116	albumin	Homo sapiens	138-151
30604175-6	2019	Of those AtELOs, AtELO1 and AtELO2 had a characteristic histidine motif and were bound to AtCb5-B.	Histidine	56-65	IKI3 family protein	Arabidopsis thaliana	28-34
30547569-5	2018	We chose a set of mutations to examine conserved Asp and Glu residues in the hydrolase active sites, as well as the ligation sphere around the catalytic calcium and a His-His dyad seen in PON1.	Histidine	171-174	paraoxonase 1	Homo sapiens	188-192
30405108-10	2018	In addition, decreased % histidine intake was associated with a decrease in insulin resistance (r = +0.38; p = 0.003), also independent of changes in BMI and energy intake.	Histidine	25-34	insulin	Homo sapiens	76-83
30512152-6	2018	Genetic analysis showed that g.7476 G&gt;A heterozygous missense mutation in exon 8 of FGG gene resulted in mutations in arginine at position 275 of fibrinogen gamma D domain to histidine (Arg275His).	Histidine	178-187	fibrinogen gamma chain	Homo sapiens	87-90
30512152-6	2018	Genetic analysis showed that g.7476 G&gt;A heterozygous missense mutation in exon 8 of FGG gene resulted in mutations in arginine at position 275 of fibrinogen gamma D domain to histidine (Arg275His).	Histidine	178-187	fibrinogen beta chain	Homo sapiens	149-159
30251657-3	2018	THB1, which is cytoplasmic and capable of nitric oxide dioxygenation activity, uses a histidine and a lysine as axial ligands to the heme iron.	Histidine	86-95	uncharacterized protein	Chlamydomonas reinhardtii	0-4
30251657-6	2018	RESULTS: Recombinant THB3, which lacks the proximal histidine but has a distal histidine, binds heme weakly.	Histidine	52-61	uncharacterized protein	Chlamydomonas reinhardtii	21-25
30251657-6	2018	RESULTS: Recombinant THB3, which lacks the proximal histidine but has a distal histidine, binds heme weakly.	Histidine	79-88	uncharacterized protein	Chlamydomonas reinhardtii	21-25
30466609-1	2018	BACKGROUND: Carboxylesterases (CEs) belong to the serine hydrolase family, and are in charge of hydrolyzing chemicals with carboxylic acid ester and amide functional groups via Ser-His-Glu.	Histidine	181-184	carboxylesterase 2	Homo sapiens	12-29
30380295-6	2018	Introduction of a solubility partner, i.e., maltose binding protein (MBP), at the N-terminus of the ATR kinase domain generated a soluble form of the protein, i.e., MBP-tagged hATR kinase domain (MBP-ATR-6X His), which was found to be catalytically active, as assessed by substrate p53 Ser-15 phosphorylation (EPPLSQEAFADLWKK).	Histidine	207-210	ATR serine/threonine kinase	Homo sapiens	100-103
30380295-6	2018	Introduction of a solubility partner, i.e., maltose binding protein (MBP), at the N-terminus of the ATR kinase domain generated a soluble form of the protein, i.e., MBP-tagged hATR kinase domain (MBP-ATR-6X His), which was found to be catalytically active, as assessed by substrate p53 Ser-15 phosphorylation (EPPLSQEAFADLWKK).	Histidine	207-210	ATR serine/threonine kinase	Homo sapiens	177-180
30535645-8	2018	Graphical abstract Schematic illustration of a fluorometric assay for alkaline phosphatase (ALP) activity that uses L-histidine protected copper nanoclusters (CuNCs), aggregation-induced quenching, and the inner filter effect between PNP and CuNCs.	Histidine	116-127	alkaline phosphatase, placental	Homo sapiens	70-90
30535645-8	2018	Graphical abstract Schematic illustration of a fluorometric assay for alkaline phosphatase (ALP) activity that uses L-histidine protected copper nanoclusters (CuNCs), aggregation-induced quenching, and the inner filter effect between PNP and CuNCs.	Histidine	116-127	alkaline phosphatase, placental	Homo sapiens	92-95
30261176-7	2018	We now present data that support the hypothesis that Keap1 directly senses Zn2+ through a cluster of amino-acids that include His-225, Cys-226, and Cys-613.	Histidine	126-129	kelch like ECH associated protein 1	Homo sapiens	53-58
30228188-3	2018	Unlike for the structure of paralog USP4, the catalytic triad is in an inactive configuration with the catalytic cysteine ~10 A apart from the catalytic histidine.	Histidine	153-162	ubiquitin specific peptidase 4	Homo sapiens	36-40
30171282-6	2018	The binding constant (Kd = 0.67 muM) revealed the micromolar sensitivity and high selectivity of the his-tagged GBP biosensor for glucose, making it suitable for TG measurements.	Histidine	101-104	latexin	Homo sapiens	32-35
30417296-4	2018	Angiotensin-converting enzyme activity in the aorta sections was determined by Hip-His-Leu hydrolysis.	Histidine	83-86	angiotensin I converting enzyme	Rattus norvegicus	0-29
30282605-7	2018	Dynamic replacement of the native sixth coordination bond of methionine-80 by lysines (72, 73, and 79) and partially also by histidines (26 and 33) provides an efficient way how to increase peroxidase-like activity of cyt c without significant conformational change at physiological conditions.	Histidine	125-135	cytochrome c, somatic	Homo sapiens	218-223
30015387-3	2018	We hypothesize that ITCs, as electrophiles, can interact with the catalytic triads (CYS, HIS, and ASP) of the proteasomal cysteine deubiquitinases USP14 and UCHL5, ultimately inhibiting their activities.	Histidine	89-92	ubiquitin C-terminal hydrolase L5	Homo sapiens	157-162
30048934-7	2018	The molecular CAT activity was inhibited due to the direct interaction of IAA with HIS 74 and TYR 357 around the active sites of CAT.	Histidine	83-86	catalase	Mus musculus	14-17
30048934-7	2018	The molecular CAT activity was inhibited due to the direct interaction of IAA with HIS 74 and TYR 357 around the active sites of CAT.	Histidine	83-86	catalase	Mus musculus	129-132
30230320-0	2018	Distinct Differences in Structural States of Conserved Histidines in Two Related Proteins: NMR Studies of the Chemokines CXCL1 and CXCL8 in the Free Form and Macromolecular Complexes.	Histidine	55-65	C-X-C motif chemokine ligand 8	Homo sapiens	131-136
30270390-7	2018	All coordinating groups present in the Fe(iii) transferrin complex are also found for Cm(iii), i.e. Asp 63, Tyr 95, Tyr 188 and His 249.	Histidine	128-131	transferrin	Homo sapiens	47-58
30270390-10	2018	The results underline an involvement of Asp 63, Tyr 95, Tyr 188 and His 249 as well as carbonate in Cm(iii) coordination at the transferrin Fe(iii) binding site.	Histidine	68-71	transferrin	Homo sapiens	128-139
30230320-3	2018	Here, we characterized the structural features of histidines in the chemokines CXCL8 and CXCL1 in the free, GAG heparin-bound, and CXCR2 receptor N-terminal domain-bound states using solution NMR spectroscopy.	Histidine	50-60	C-X-C motif chemokine ligand 8	Homo sapiens	79-84
30230320-4	2018	CXCL8 and CXCL1 share two conserved histidines, one in the N-loop and the other in the 30s loop.	Histidine	36-46	C-X-C motif chemokine ligand 8	Homo sapiens	0-5
30230320-5	2018	In CXCL8, both histidines exist in the Nepsilon2 tautomeric state in the free, GAG-bound, and receptor-bound forms.	Histidine	15-25	C-X-C motif chemokine ligand 8	Homo sapiens	3-8
30364315-7	2018	Purified histidine-tagged versions of the annotated DAGKs from Hyphomicrobium nitrativorans and M. nodulans (respectively, sharing 69 and 84% identity with DmrA) showed only low activity in phosphorylating 1,2-dihexanoyl-sn-glycerol when compared with a commercial DAGK from Escherichia coli.	Histidine	9-18	MEXAM1_RS20320	Methylobacterium extorquens AM1	156-160
30279180-4	2018	Mutation of aspartic acid 378 of hnRNPDL to either asparagine or histidine has been associated with limb girdle muscular dystrophy.	Histidine	65-74	heterogeneous nuclear ribonucleoprotein D like	Homo sapiens	33-40
30209628-4	2018	However, in the presence of L-histidine aptamers (DNA1 and DNA2), the partial strands of DNA1 and DNA2 hybridize to form a DNA duplex with a swing structure.	Histidine	28-39	DNA replication helicase/nuclease 2	Homo sapiens	59-63
29778008-5	2018	The levels of 19 out of the 67 altered metabolites including histidine, kynurenine, and 3-hydroxybutyrate (BHBA), recovered after LPV/r-based antiretroviral therapy, and histidine was positively correlated with the presence of CD4 + T lymphocytes.	Histidine	170-179	CD4 molecule	Homo sapiens	227-230
30370829-1	2018	INTRODUCTION:: The dipeptide histidine-leucine (His-Leu) is formed in the process of converting angiotensin I into angiotensin II.	Histidine	48-51	angiotensinogen	Rattus norvegicus	115-129
29442210-1	2018	Background The hexapeptide 4A6 (Ac-Thr(tBu)-His(Bzl)-Thr(Bzl)-Nle-Glu(OtBu)-Gly-Bza) was isolated from a peptide library constructed to identify peptide-based transport inhibitors of multidrug resistance (MDR) efflux pumps including P-glycoprotein and Multidrug Resistance-associated Protein 1.	Histidine	44-47	ATP binding cassette subfamily C member 1	Homo sapiens	252-293
30237127-6	2018	Here we show, using a newly-developed MS protocol, that HOCl and an enzymatic MPO system, generate site-specific dose-dependent Tyr chlorination and dichlorination (up to 16 of 100 residues modified), and oxidation of Trp (7 of 39 residues), Met (3 of 26) and His (1 of 55) within selected FN domains, and particularly the heparin- and cell-binding regions.	Histidine	260-263	myeloperoxidase	Homo sapiens	78-81
30012884-4	2018	We identified a conserved histidine in GAPDH that is needed for its robust heme binding both in vitro and in mammalian cells.	Histidine	26-35	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	39-44
30012884-5	2018	Substitution of this histidine, and the consequent decreases in GAPDH heme binding, antagonized heme delivery to both cytosolic and nuclear hemeprotein targets, including inducible nitric-oxide synthase (iNOS) in murine macrophages and the nuclear transcription factor Hap1 in yeast, even though this GAPDH variant caused cellular levels of labile heme to rise dramatically.	Histidine	21-30	nitric oxide synthase 2, inducible	Mus musculus	171-202
30012884-5	2018	Substitution of this histidine, and the consequent decreases in GAPDH heme binding, antagonized heme delivery to both cytosolic and nuclear hemeprotein targets, including inducible nitric-oxide synthase (iNOS) in murine macrophages and the nuclear transcription factor Hap1 in yeast, even though this GAPDH variant caused cellular levels of labile heme to rise dramatically.	Histidine	21-30	nitric oxide synthase 2, inducible	Mus musculus	204-208
30012884-5	2018	Substitution of this histidine, and the consequent decreases in GAPDH heme binding, antagonized heme delivery to both cytosolic and nuclear hemeprotein targets, including inducible nitric-oxide synthase (iNOS) in murine macrophages and the nuclear transcription factor Hap1 in yeast, even though this GAPDH variant caused cellular levels of labile heme to rise dramatically.	Histidine	21-30	huntingtin-associated protein 1	Mus musculus	269-273
30012884-5	2018	Substitution of this histidine, and the consequent decreases in GAPDH heme binding, antagonized heme delivery to both cytosolic and nuclear hemeprotein targets, including inducible nitric-oxide synthase (iNOS) in murine macrophages and the nuclear transcription factor Hap1 in yeast, even though this GAPDH variant caused cellular levels of labile heme to rise dramatically.	Histidine	21-30	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	301-306
30209628-4	2018	However, in the presence of L-histidine aptamers (DNA1 and DNA2), the partial strands of DNA1 and DNA2 hybridize to form a DNA duplex with a swing structure.	Histidine	28-39	DNA replication helicase/nuclease 2	Homo sapiens	98-102
30140002-6	2018	APR-246/MQ also inhibits Trxs in mutant p53-expressing Saos-2 His-273 cells, showing modification of Trx1 and mitochondrial Trx2.	Histidine	62-65	tumor protein p53	Homo sapiens	40-43
29908817-8	2018	Using wild-type protein and a double alanine mutant we demonstrated that heme binds to HlyC via histidine 151 (H151).	Histidine	96-105	hemolysin transport protein	Escherichia coli	87-91
29944203-4	2018	Through the use of various functional nucleic acids, including aptamers and DNAzymes, as recognition modules, the versatility of D-CID in inducing c-Met signaling upon addition of various small-molecular or ionic cues, including ATP, histidine, and Zn2+ , is demonstrated.	Histidine	234-243	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	147-152
29787766-6	2018	The H112N mutant was found to be dimeric, but devoid of catalytic activity, due to the loss of the catalytically essential histidine; nevertheless, it exhibited high affinity to AMP and a HINT1 inhibitor.	Histidine	123-132	histidine triad nucleotide binding protein 1	Homo sapiens	188-193
30135643-7	2018	Based on in silico analysis, Ser 252, His 470 and Asp 474 are predicted to be the catalytic triad responsible for CPT1C palmitoyl thioesterase (PTE) activity.	Histidine	38-41	carnitine palmitoyltransferase 1c	Mus musculus	114-119
30135643-9	2018	Moreover, the histidine residue (His 470) of CPT1C is crucial for the increase in GluA1 surface expression in neurons and the H470A mutation impairs the depalmitoylating catalytic activity of CPT1C.	Histidine	14-23	carnitine palmitoyltransferase 1c	Mus musculus	45-50
30135643-9	2018	Moreover, the histidine residue (His 470) of CPT1C is crucial for the increase in GluA1 surface expression in neurons and the H470A mutation impairs the depalmitoylating catalytic activity of CPT1C.	Histidine	14-23	carnitine palmitoyltransferase 1c	Mus musculus	192-197
30135643-9	2018	Moreover, the histidine residue (His 470) of CPT1C is crucial for the increase in GluA1 surface expression in neurons and the H470A mutation impairs the depalmitoylating catalytic activity of CPT1C.	Histidine	33-36	carnitine palmitoyltransferase 1c	Mus musculus	45-50
30135643-9	2018	Moreover, the histidine residue (His 470) of CPT1C is crucial for the increase in GluA1 surface expression in neurons and the H470A mutation impairs the depalmitoylating catalytic activity of CPT1C.	Histidine	33-36	carnitine palmitoyltransferase 1c	Mus musculus	192-197
29989630-5	2018	This critical histidine-to-asparagine substitution, at residue 43, was proposed to underlie manganese transport specificity of SLC30A10.	Histidine	14-23	solute carrier family 30 member 10	Homo sapiens	127-135
29989630-11	2018	Importantly, unlike SLC30A10, the histidine residue of the HXXXD motif of SLC30A1/ZnT1 was required for zinc transport.	Histidine	34-43	solute carrier family 30 member 1	Homo sapiens	82-86
29635803-11	2018	In contrast, HI decreased AMPK activation in both cell lines, whereas it increased ERK1/2 levels in PNT1A and decreased them in PC3 (reflecting greater cell proliferation only in non-tumor cells).	Histidine	13-15	mitogen-activated protein kinase 3	Homo sapiens	83-89
29885535-4	2018	administration of histamine precursor, l-histidine significantly attenuated the number of marble buried in marble burying behavior (MBB) test as well as obliterated the persistent behavior induced by 5-HT1A receptor agonist, 8-OH-DPAT in T-Maze test.	Histidine	39-50	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	200-215
29967479-3	2018	Here, we demonstrate that ETV1 (ER81)-dependent gene networks dictate the unique electrophysiological characteristics of atrial and His-Purkinje myocytes.	Histidine	132-135	ETS variant transcription factor 1	Homo sapiens	26-30
29967479-3	2018	Here, we demonstrate that ETV1 (ER81)-dependent gene networks dictate the unique electrophysiological characteristics of atrial and His-Purkinje myocytes.	Histidine	132-135	ETS variant transcription factor 1	Homo sapiens	32-36
29901068-13	2018	In vivo, the administration of HI-TOPK-032 suppressed tumor growth in an ATLL xenograft model.	Histidine	31-33	PDZ binding kinase	Homo sapiens	34-38
29694915-6	2018	As a second, independent finding, we report that there are histidines in close proximity to the Bcl-xL deamidation sites that are highly conserved in land-dwelling species and we present evidence that deamidation of human Bcl-xL is intramolecularly catalyzed in a manner that is dependent upon these histidines.	Histidine	59-69	BCL2 like 1	Homo sapiens	96-102
29694915-6	2018	As a second, independent finding, we report that there are histidines in close proximity to the Bcl-xL deamidation sites that are highly conserved in land-dwelling species and we present evidence that deamidation of human Bcl-xL is intramolecularly catalyzed in a manner that is dependent upon these histidines.	Histidine	59-69	BCL2 like 1	Homo sapiens	222-228
29694915-6	2018	As a second, independent finding, we report that there are histidines in close proximity to the Bcl-xL deamidation sites that are highly conserved in land-dwelling species and we present evidence that deamidation of human Bcl-xL is intramolecularly catalyzed in a manner that is dependent upon these histidines.	Histidine	300-310	BCL2 like 1	Homo sapiens	96-102
29694915-6	2018	As a second, independent finding, we report that there are histidines in close proximity to the Bcl-xL deamidation sites that are highly conserved in land-dwelling species and we present evidence that deamidation of human Bcl-xL is intramolecularly catalyzed in a manner that is dependent upon these histidines.	Histidine	300-310	BCL2 like 1	Homo sapiens	222-228
29694915-7	2018	Further, we present evidence that these histidines act as a pH-sensitive switch that enhances the effect of the increase in pH on the rate of Bcl-xL deamidation.	Histidine	40-50	BCL2 like 1	Homo sapiens	142-148
29694915-8	2018	The conservation of such histidines implies that human Bcl-xL is in essence "designed" to be deamidated, which provides further evidence that deamidation serves as a bona fide regulatory post-translational modification of Bcl-xL.	Histidine	25-35	BCL2 like 1	Homo sapiens	55-61
29930513-10	2018	Histidine administration also significantly increased the protein expression level of zonula occludens protein 1, an indicator of the integrity of blood-brain barrier (BBB).	Histidine	0-9	tight junction protein 1	Mus musculus	86-112
29281262-11	2018	Taken together, these establish unambiguously a four-His coordination of the metal ion in the model systems, supporting the presence of our postulated binding site in the NGF/TrkA complex.	Histidine	53-56	nerve growth factor	Homo sapiens	171-174
29659163-2	2018	In this study, the alpha-MSH-derived peptide NAP-NS1 (Nle-Asp-His-d-Phe-Arg-Trp-Gly-NH2 ) with and without linkers was conjugated with 5-(bis(pyridin-2-ylmethyl)amino)pentanoic acid (DPA-COOH) and labeled with [99m Tc]Tc-tricarbonyl by two methods.	Histidine	62-65	proopiomelanocortin	Homo sapiens	19-28
29849146-6	2018	Here we identify a histidine-rich domain in cyclin T1 that promotes the hyperphosphorylation of the CTD and stimulation of transcription by CDK9.	Histidine	19-28	cyclin T1	Homo sapiens	44-53
29849146-6	2018	Here we identify a histidine-rich domain in cyclin T1 that promotes the hyperphosphorylation of the CTD and stimulation of transcription by CDK9.	Histidine	19-28	cyclin dependent kinase 9	Homo sapiens	140-144
29849146-8	2018	In addition to cyclin T1, at least one other kinase-DYRK1A 6 -also uses a histidine-rich domain to target and hyperphosphorylate the CTD.	Histidine	74-83	cyclin T1	Homo sapiens	15-24
29967682-4	2018	His bundle pacing activates the ventricles via the native His-Purkinje system, resulting in true physiological pacing, and, therefore, is a promising alternate site for pacing in bradycardia and traditional CRT indications in cases where it can overcome left bundle branch block.	Histidine	0-3	calcitonin receptor	Homo sapiens	207-210
29696512-7	2018	Expression of PI3K-Akt-mTOR/JNK (24 h after HI or OGD/R) proteins was detected by Western blotting after stimulation with HI, NGR1, LY294002 (PI3K inhibitor), 740Y-P (PI3K agonist), or ICI 182780(estrogen receptors inhibitor).	Histidine	44-46	AKT serine/threonine kinase 1	Rattus norvegicus	19-22
29795045-6	2018	The residue that plays a major role in determining the diverse pKa values of the proton shuttle is the one in position four, namely His for hCA II and Gly for hCA VII.	Histidine	132-135	carbonic anhydrase 7	Homo sapiens	159-166
29449016-6	2018	Pulse radiolysis experiments, however, clearly revealed an axial ligand exchange from Cys to His immediately after the reduction of the heme iron to form a 5-coordinate His-ligated heme in heme-bound IRP2, whereas the 5-coordinate His-ligated heme was not observed after the reduction of heme-bound IRP1.	Histidine	93-96	iron responsive element binding protein 2	Homo sapiens	200-204
29860820-0	2018	[Interaction between abnormal expression of fragile histidine triad and methyl-CpG-binding protein 2 on cervical cancerization].	Histidine	52-61	methyl-CpG binding protein 2	Homo sapiens	72-100
29860820-1	2018	Objective: To explore the relationship between abnormal expression of fragile histidine triad (FHIT) gene and methyl-CpG-binding protein 2 (MeCP2) as well as their interaction on cervical cancerization.	Histidine	78-87	methyl-CpG binding protein 2	Homo sapiens	110-138
29860820-1	2018	Objective: To explore the relationship between abnormal expression of fragile histidine triad (FHIT) gene and methyl-CpG-binding protein 2 (MeCP2) as well as their interaction on cervical cancerization.	Histidine	78-87	methyl-CpG binding protein 2	Homo sapiens	140-145
29717998-0	2018	In situ proteolysis of an N-terminal His tag with thrombin improves the diffraction quality of human aldo-keto reductase 1C3 crystals.	Histidine	37-40	coagulation factor II, thrombin	Homo sapiens	50-58
29449016-6	2018	Pulse radiolysis experiments, however, clearly revealed an axial ligand exchange from Cys to His immediately after the reduction of the heme iron to form a 5-coordinate His-ligated heme in heme-bound IRP2, whereas the 5-coordinate His-ligated heme was not observed after the reduction of heme-bound IRP1.	Histidine	169-172	iron responsive element binding protein 2	Homo sapiens	200-204
29449016-6	2018	Pulse radiolysis experiments, however, clearly revealed an axial ligand exchange from Cys to His immediately after the reduction of the heme iron to form a 5-coordinate His-ligated heme in heme-bound IRP2, whereas the 5-coordinate His-ligated heme was not observed after the reduction of heme-bound IRP1.	Histidine	169-172	iron responsive element binding protein 2	Homo sapiens	200-204
29449016-7	2018	Considering that the oxidative modification is only observed in heme-bound IRP2, but not IRP1, probably owing to the structural flexibility of IRP2, we propose that the transient 5-coordinate His-ligated heme is a prerequisite for oxidative modification of heme-bound IRP2, which functionally differentiates heme binding of IRP2 from that of IRP1.	Histidine	192-195	iron responsive element binding protein 2	Homo sapiens	75-79
29449016-7	2018	Considering that the oxidative modification is only observed in heme-bound IRP2, but not IRP1, probably owing to the structural flexibility of IRP2, we propose that the transient 5-coordinate His-ligated heme is a prerequisite for oxidative modification of heme-bound IRP2, which functionally differentiates heme binding of IRP2 from that of IRP1.	Histidine	192-195	iron responsive element binding protein 2	Homo sapiens	143-147
29449016-7	2018	Considering that the oxidative modification is only observed in heme-bound IRP2, but not IRP1, probably owing to the structural flexibility of IRP2, we propose that the transient 5-coordinate His-ligated heme is a prerequisite for oxidative modification of heme-bound IRP2, which functionally differentiates heme binding of IRP2 from that of IRP1.	Histidine	192-195	iron responsive element binding protein 2	Homo sapiens	143-147
29449016-7	2018	Considering that the oxidative modification is only observed in heme-bound IRP2, but not IRP1, probably owing to the structural flexibility of IRP2, we propose that the transient 5-coordinate His-ligated heme is a prerequisite for oxidative modification of heme-bound IRP2, which functionally differentiates heme binding of IRP2 from that of IRP1.	Histidine	192-195	iron responsive element binding protein 2	Homo sapiens	143-147
29657009-6	2018	Plasminogen binding assay showed that His-Tseno could bind to human plasminogen and generate plasmin activated by a tissue-type plasminogen activator (t-PA).	Histidine	38-41	plasminogen activator, tissue type	Homo sapiens	116-149
29084827-1	2018	68Ga-labeled DOTA-4-amino-1-carboxymethyl-piperidine-d-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2 (68Ga-RM2) is a synthetic bombesin receptor antagonist that targets gastrin-releasing peptide receptor (GRPr).	Histidine	79-82	gastrin releasing peptide receptor	Homo sapiens	163-197
29084827-1	2018	68Ga-labeled DOTA-4-amino-1-carboxymethyl-piperidine-d-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2 (68Ga-RM2) is a synthetic bombesin receptor antagonist that targets gastrin-releasing peptide receptor (GRPr).	Histidine	79-82	gastrin releasing peptide receptor	Homo sapiens	199-203
29657009-6	2018	Plasminogen binding assay showed that His-Tseno could bind to human plasminogen and generate plasmin activated by a tissue-type plasminogen activator (t-PA).	Histidine	38-41	plasminogen activator, tissue type	Homo sapiens	151-155
29481839-0	2018	Anammox Organism KSU-1 Expresses a Novel His/DOPA Ligated Cytochrome c.	Histidine	41-44	cytochrome c, somatic	Homo sapiens	58-70
29744287-1	2018	Histidyl-tRNA synthetase (Hars) catalyzes the ligation of histidine residues to cognate tRNA.	Histidine	58-67	histidyl-tRNA synthetase	Danio rerio	0-24
29744287-1	2018	Histidyl-tRNA synthetase (Hars) catalyzes the ligation of histidine residues to cognate tRNA.	Histidine	58-67	histidyl-tRNA synthetase	Danio rerio	26-30
29481839-11	2018	We revealed that an anammox bacterium strain KSU-1 expresses a novel cytochrome c having an unprecedented His/3,4-dihydroxyphenylalanine coordinating heme.	Histidine	106-109	cytochrome c, somatic	Homo sapiens	69-81
29397068-5	2018	His-7, Glu-9 and Asp-15 of GLP-1 act together to destabilise transmembrane helix 6 and extracellular loop 3 in order to generate an active conformation of GLP-1R.	Histidine	0-3	glucagon	Homo sapiens	27-32
29578521-7	2018	Sortilin tagged with six histidines was expressed in mammalian cells, and isolated from cell lysates using Cobalt beads.	Histidine	25-35	sortilin 1	Homo sapiens	0-8
29562234-9	2018	Thus, LHPP is a protein histidine phosphatase and tumour suppressor, suggesting that deregulated histidine phosphorylation is oncogenic.	Histidine	24-33	phospholysine phosphohistidine inorganic pyrophosphate phosphatase	Homo sapiens	6-10
29480716-1	2018	Previous work with the four-helix-bundle protein cytochrome c" from Rhodopseudomonas palustris using histidine-heme loop formation methods revealed fold-specific deviations from random coil behavior in its denatured state ensemble.	Histidine	101-110	cytochrome c, somatic	Homo sapiens	49-61
29480716-6	2018	Furthermore, engineered histidine residues in UBA(2) strongly destabilize the iso-1-cytochrome c domain.	Histidine	24-33	cytochrome c, somatic	Homo sapiens	84-96
28689454-6	2018	Reaction phenotyping with 12 commercial recombinant human UGTs, as well as with the Helsinki laboratory UGT1A10 that carry a C-terminal His-tag (UGT1A10-H), revealed that UGT1A10-H catalyzes xanthotoxol glucuronidation at the highest rate, followed by UGT1A8.	Histidine	136-139	UDP glucuronosyltransferase family 1 member A10	Homo sapiens	104-111
28617100-6	2018	Molecular docking study revealed that compound 7 could combine both catalytic active site (CAS) and peripheral active site (PAS) of AChE with four points (Trp84, Trp279, Tyr70 and Phe330), while it could bind with BuChE via only His 20.	Histidine	229-232	acetylcholinesterase (Cartwright blood group)	Homo sapiens	132-136
29061519-0	2018	A novel reverse micellar purification strategy for histidine tagged human interferon gamma (hIFN-gamma) protein from Pichia pastoris.	Histidine	51-60	interferon gamma	Homo sapiens	74-102
29513344-0	2018	Antioxidant activity and inhibitory effects of 2-hydroxy-3-methylcyclopent-2-enone isolated from ribose-histidine Maillard reaction products on aldose reductase and tyrosinase.	Histidine	104-113	aldo-keto reductase family 1 member B	Homo sapiens	144-160
29513344-3	2018	Among the MRPs, ribose-histidine MRPs (RH-MRPs) showed the highest inhibitory activities on the ABTS+ radical scavenging ability, aldose reductase (AR), and tyrosinase compared to other MRPs.	Histidine	23-32	aldo-keto reductase family 1 member B	Homo sapiens	130-146
29513344-3	2018	Among the MRPs, ribose-histidine MRPs (RH-MRPs) showed the highest inhibitory activities on the ABTS+ radical scavenging ability, aldose reductase (AR), and tyrosinase compared to other MRPs.	Histidine	23-32	aldo-keto reductase family 1 member B	Homo sapiens	148-150
29220567-7	2018	Although KDM6A and KDM6B differ in primary sequence, particularly in the H3L20 binding pocket of the zinc binding domains, where two histidines in KDM6A have been replaced by a glutamate and a tyrosine, they bind H3(17-23) in a very similar fashion.	Histidine	133-143	lysine demethylase 6A	Homo sapiens	9-14
29220567-7	2018	Although KDM6A and KDM6B differ in primary sequence, particularly in the H3L20 binding pocket of the zinc binding domains, where two histidines in KDM6A have been replaced by a glutamate and a tyrosine, they bind H3(17-23) in a very similar fashion.	Histidine	133-143	lysine demethylase 6A	Homo sapiens	147-152
29155052-11	2018	Histidines and lysines in helices 5-8 of apoA-I were highly susceptible to oxPL modifications, while lysines in helices 1, 2, 4 and 10 were resistant to modification by oxPL.	Histidine	0-10	apolipoprotein A1	Homo sapiens	41-47
29155052-12	2018	In plasma exposed to oxidation or synthetic oxPL, oxPL modification was highly selective, and four histidines (H155, H162, H193 and H199) in helices 6-8 of apoA-I were the main modification target.	Histidine	99-109	apolipoprotein A1	Homo sapiens	156-162
28689454-6	2018	Reaction phenotyping with 12 commercial recombinant human UGTs, as well as with the Helsinki laboratory UGT1A10 that carry a C-terminal His-tag (UGT1A10-H), revealed that UGT1A10-H catalyzes xanthotoxol glucuronidation at the highest rate, followed by UGT1A8.	Histidine	136-139	UDP glucuronosyltransferase family 1 member A10	Homo sapiens	145-152
28689454-6	2018	Reaction phenotyping with 12 commercial recombinant human UGTs, as well as with the Helsinki laboratory UGT1A10 that carry a C-terminal His-tag (UGT1A10-H), revealed that UGT1A10-H catalyzes xanthotoxol glucuronidation at the highest rate, followed by UGT1A8.	Histidine	136-139	UDP glucuronosyltransferase family 1 member A10	Homo sapiens	145-152
29643986-4	2018	Here, we reported that an endotoxin-free His-GRP78 protein was purified in vitro that simulates original secreted GRP78.	Histidine	41-44	heat shock protein family A (Hsp70) member 5	Homo sapiens	45-50
29387685-3	2017	The Hsp90-mediated activation of NLR receptors (Nucleotide-binding domain and Leucine-rich Repeat) in the innate immunity of both plants and animals is dependent on the co-chaperone Sgt1 and in plants on Rar1, a cysteine- and histidine-rich domain (CHORD)-containing protein.	Histidine	226-235	SGT1 homolog, MIS12 kinetochore complex assembly cochaperone	Homo sapiens	182-186
29215101-1	2018	The extracellular domain E2 of the amyloid precursor protein (APP) features a His-rich metal-binding site (denoted as the M1 site).	Histidine	78-81	amyloid beta precursor protein	Homo sapiens	35-60
29643986-4	2018	Here, we reported that an endotoxin-free His-GRP78 protein was purified in vitro that simulates original secreted GRP78.	Histidine	41-44	heat shock protein family A (Hsp70) member 5	Homo sapiens	114-119
29643986-5	2018	Through analyzing GRP78 concentration in serum samples from 32 colon cancer patients, 40 nM His-GRP78 was selected as an optimized dose to treat cells.	Histidine	92-95	heat shock protein family A (Hsp70) member 5	Homo sapiens	18-23
29643986-5	2018	Through analyzing GRP78 concentration in serum samples from 32 colon cancer patients, 40 nM His-GRP78 was selected as an optimized dose to treat cells.	Histidine	92-95	heat shock protein family A (Hsp70) member 5	Homo sapiens	96-101
29203646-1	2018	The Asp-His-His and Asp-His-His-associated (DHH/DHHA1) domain-containing phosphodiesterases (PDEs) that catalyze degradation of cyclic di-adenosine monophosphate (c-di-AMP) could be subdivided into two subfamilies based on the final product [5"-phosphadenylyl-adenosine (5"-pApA) or AMP].	Histidine	8-11	desert hedgehog signaling molecule	Homo sapiens	44-47
29203646-1	2018	The Asp-His-His and Asp-His-His-associated (DHH/DHHA1) domain-containing phosphodiesterases (PDEs) that catalyze degradation of cyclic di-adenosine monophosphate (c-di-AMP) could be subdivided into two subfamilies based on the final product [5"-phosphadenylyl-adenosine (5"-pApA) or AMP].	Histidine	12-15	desert hedgehog signaling molecule	Homo sapiens	44-47
29249312-11	2018	Histidine almost suppressed the LPS-induced IL-8 expression in the feline macrophages (P&lt;0.05).	Histidine	0-9	C-X-C motif chemokine ligand 8	Felis catus	44-48
29682607-8	2018	The cysteine-rich region has been implicated in protein-protein interaction with client proteins, farnesylation of YDJ1 facilitates attachment of YDJ1 to the ER and perinuclear membranes, and the histidine-proline-aspartic acid (HPD) tripeptide motif present in the J-domain, is responsible for the regulation of the ATPase activity of HSP70s.	Histidine	196-205	type I HSP40 co-chaperone YDJ1	Saccharomyces cerevisiae S288C	115-119
29305823-0	2018	Semi-Mechanistic Population Pharmacokinetic Modeling of L-Histidine Disposition and Brain Uptake in Wildtype and Pht1 Null Mice.	Histidine	56-67	solute carrier family 15, member 4	Mus musculus	113-117
29305823-1	2018	PURPOSE: To develop a semi-mechanistic population pharmacokinetic (PK) model to quantitate the disposition kinetics of L-histidine, a peptide-histidine transporter 1 (PHT1) substrate, in the plasma, cerebrospinal fluid and brain parenchyma of wildtype (WT) and Pht1 knockout (KO) mice.	Histidine	119-130	solute carrier family 15, member 4	Mus musculus	134-165
29305823-1	2018	PURPOSE: To develop a semi-mechanistic population pharmacokinetic (PK) model to quantitate the disposition kinetics of L-histidine, a peptide-histidine transporter 1 (PHT1) substrate, in the plasma, cerebrospinal fluid and brain parenchyma of wildtype (WT) and Pht1 knockout (KO) mice.	Histidine	119-130	solute carrier family 15, member 4	Mus musculus	167-171
29305823-1	2018	PURPOSE: To develop a semi-mechanistic population pharmacokinetic (PK) model to quantitate the disposition kinetics of L-histidine, a peptide-histidine transporter 1 (PHT1) substrate, in the plasma, cerebrospinal fluid and brain parenchyma of wildtype (WT) and Pht1 knockout (KO) mice.	Histidine	119-130	solute carrier family 15, member 4	Mus musculus	261-265
29305823-4	2018	The disposition of L-His between the plasma, brain, and CSF was described by a combination of PHT1-mediated uptake, CSF bulk flow and first-order micro-rate constants.	Histidine	19-24	solute carrier family 15, member 4	Mus musculus	94-98
29305823-6	2018	A more rapid uptake of L-His in brain parenchyma was observed in WT mice due to PHT1-mediated uptake, a process characterized by a Michaelis-Menten component (Vmax = 0.051 nmoL/min and Km = 34.94 muM).	Histidine	23-28	solute carrier family 15, member 4	Mus musculus	80-84
29755541-6	2018	The structure-activity relationships acquired disclosed that compound 2d with 4-(azido phenyl) group as pharmacophore and histidine as amino acid gives the essential geometry to provide inhibition of the COX-2 enzyme with high selectivity.	Histidine	122-131	prostaglandin-endoperoxide synthase 2	Homo sapiens	204-209
29286308-1	2017	Selenoprotein K (SELENOK) is a selenocysteine (Sec)-containing protein localized in the endoplasmic reticulum (ER) membrane where it interacts with the DHHC6 (where single letter symbols represent Asp-His-His-Cys amino acids) enzyme to promote protein acyl transferase (PAT) reactions.	Histidine	201-204	selenoprotein K	Mus musculus	0-15
29286308-1	2017	Selenoprotein K (SELENOK) is a selenocysteine (Sec)-containing protein localized in the endoplasmic reticulum (ER) membrane where it interacts with the DHHC6 (where single letter symbols represent Asp-His-His-Cys amino acids) enzyme to promote protein acyl transferase (PAT) reactions.	Histidine	201-204	selenoprotein K	Mus musculus	17-24
29286308-1	2017	Selenoprotein K (SELENOK) is a selenocysteine (Sec)-containing protein localized in the endoplasmic reticulum (ER) membrane where it interacts with the DHHC6 (where single letter symbols represent Asp-His-His-Cys amino acids) enzyme to promote protein acyl transferase (PAT) reactions.	Histidine	201-204	zinc finger, DHHC domain containing 6	Mus musculus	152-157
28828544-4	2017	In two affected patients at our institutions, we performed RT-PCR and ELISA of prolactin secretagogues that are produced by vascular tissue and/or upregulated in pregnancy: AGT (encoding angiotensinogen), TAC1 (encoding substance P), HDC (encoding the enzyme responsible for conversion of histidine to histamine), and prolactin-releasing hormone (PRLH).	Histidine	289-298	prolactin	Homo sapiens	79-88
29190078-2	2017	The canonical peptides are Gly-His-Lys and Asp-Ala-His-Lys (from the wound healing factor and human serum albumin, respectively).	Histidine	51-54	albumin	Homo sapiens	100-113
29486703-5	2017	Preparations of purified NEP with either N- or C-terminal (His)6-tag were obtained using Ni-NTA agarose affinity chromatography with yield of more than 20 mg per liter of culture.	Histidine	59-62	membrane metalloendopeptidase	Homo sapiens	25-28
28682389-5	2017	Data suggest that the histidine needed to form the bis-histidine site in the low spin heme-Abeta complex is likely to be involved in the high affinity Cu binding site in the heme-Cu-Abeta complex.	Histidine	22-31	amyloid beta precursor protein	Homo sapiens	91-96
29047228-4	2017	Photoactivation causes oxidative damage to specific histidine residues in the key proteins in aldose reductase and heat-shock protein-70 within living cancer cells.	Histidine	52-61	aldo-keto reductase family 1 member B	Homo sapiens	94-110
28815695-0	2017	A distinctive histidine residue is essential for in vivo glycation-inactivation of human CD59 transgenically expressed in mice erythrocytes: Implications for human diabetes complications.	Histidine	14-23	CD59 molecule (CD59 blood group)	Homo sapiens	89-93
28801345-4	2017	HLA-DRB1 His/Phe13beta stratifies with ACPA-positive RA, while His13betaSer polymorphisms stratify with ACPA-negative RA and RA protection.	Histidine	9-12	major histocompatibility complex, class II, DR beta 1	Homo sapiens	0-8
29061826-7	2017	A significant reduction in the number of UVA-induced apoptotic cells and caspase-3 activation was observed when histidine was present, which suggested that photodynamically-generated singlet oxygen is an important mediator of apoptosis.	Histidine	112-121	caspase 3	Homo sapiens	73-82
29125116-1	2017	The histidine triad nucleotide binding protein1(HINT1),which belongs to the histidine triad(HIT) enzyme superfamily,exerts its enzymic activities as hydrolase or transferase.	Histidine	4-13	histidine triad nucleotide binding protein 1	Homo sapiens	48-53
28984882-1	2017	As a member of the histidine triad (HIT) protein superfamily, human histidine triad nucleotide binding protein 1 (hHint1) serves as an efficient enzyme in the hydrolysis of phosphoramidate.	Histidine	19-28	histidine triad nucleotide binding protein 1	Homo sapiens	68-112
28984882-1	2017	As a member of the histidine triad (HIT) protein superfamily, human histidine triad nucleotide binding protein 1 (hHint1) serves as an efficient enzyme in the hydrolysis of phosphoramidate.	Histidine	19-28	histidine triad nucleotide binding protein 1	Homo sapiens	114-120
28579117-2	2017	The core sequence of NDP-alpha-MSH, His-Phe-Arg-Trp, is important for ligand binding and biological activities at the melanocortin receptor subtypes (MCRs).	Histidine	36-39	proopiomelanocortin	Homo sapiens	25-34
28910862-7	2017	In addition, recombinant His-tagged Abeta42 was successfully expressed in Escherichia coli BL21 (DE3) and not only readily formed Abeta complexes, but also inhibited the proliferation of SH-SY5Y cells and E. coli.	Histidine	25-28	amyloid beta precursor protein	Homo sapiens	36-41
28987271-8	2017	The strong CO-independent action of CORM-2 on Kv11.1 and Kv1.5 channels can be completely abolished when CORM-2 is applied in the presence of an excess of free histidine or human serum albumin; cysteine and methionine are further potential targets.	Histidine	160-169	potassium voltage-gated channel subfamily A member 5	Homo sapiens	57-62
28923481-0	2017	ADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after Histidine 157.	Histidine	147-156	triggering receptor expressed on myeloid cells 2	Homo sapiens	104-110
28923481-0	2017	ADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after Histidine 157.	Histidine	147-156	triggering receptor expressed on myeloid cells 2	Homo sapiens	105-110
28682389-5	2017	Data suggest that the histidine needed to form the bis-histidine site in the low spin heme-Abeta complex is likely to be involved in the high affinity Cu binding site in the heme-Cu-Abeta complex.	Histidine	22-31	amyloid beta precursor protein	Homo sapiens	182-187
28653316-7	2017	Altogether, we found that AFP interacts with caspase-3 through precise amino acids, namely loop-4 residues Glu-248, Asp-253 and His-257.	Histidine	128-131	alpha fetoprotein	Homo sapiens	26-29
28855300-5	2017	TREM2 is shed by proteases of the ADAM (a disintegrin and metalloproteinase domain containing protein) family C-terminal to histidine 157, a position where an AD-associated coding variant has been discovered (p.H157Y) in the Han Chinese population.	Histidine	124-133	triggering receptor expressed on myeloid cells 2	Homo sapiens	0-5
28653316-7	2017	Altogether, we found that AFP interacts with caspase-3 through precise amino acids, namely loop-4 residues Glu-248, Asp-253 and His-257.	Histidine	128-131	caspase 3	Homo sapiens	45-54
29058294-7	2017	from a tryptophan codon (TAT) to a histidine codon (CAT).	Histidine	35-44	catalase	Homo sapiens	52-55
29086874-1	2017	BACKGROUND: The paper examines Co(II)-amino acid-imidazole systems (where amino acid = L-alpha-amino acid: alanine, asparagine, histidine) which, when in aqueous solutions, activate and reversibly take up dioxygen, while maintaining the structural scheme of the heme group (imidazole as axial ligand and O2 uptake at the sixth, trans position) thus imitating natural respiratory pigments such as myoglobin and hemoglobin.	Histidine	128-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
28739258-3	2017	The role of metal ions in regulating postsynaptic transmission is well known, and the active site of hHint1 contains multiple histidines.	Histidine	126-136	histidine triad nucleotide binding protein 1	Homo sapiens	101-107
28710679-6	2017	Thereafter, either free p53 liberated from the fusion protein through thrombin treatment or Histidine-tagged p53 were recognized efficiently by the selected phage.	Histidine	92-101	tumor protein p53	Homo sapiens	109-112
28874603-6	2017	An Arg-to-His, but not Arg-to-Lys, mutation in the transcription factor p53 (p53-R273H) decreased its transcriptional activity and attenuated the DNA damage response in fibroblasts and breast cancer cells with high pHi.	Histidine	10-13	tumor protein p53	Homo sapiens	72-75
27966992-2	2017	The reason appears to be poor activity of the commercial UGT1A10 that is used by many laboratories, and here we have tested it by comparison with our recombinant His-tagged UGT1A10 (designated as UGT1A10-H), both expressed in insect cells.	Histidine	162-165	UDP glucuronosyltransferase family 1 member A10	Homo sapiens	173-180
28874603-6	2017	An Arg-to-His, but not Arg-to-Lys, mutation in the transcription factor p53 (p53-R273H) decreased its transcriptional activity and attenuated the DNA damage response in fibroblasts and breast cancer cells with high pHi.	Histidine	10-13	tumor protein p53	Homo sapiens	77-80
28472682-5	2017	Molecule docking supported that histidine-B5 of insulin binds with heme-Fe.	Histidine	32-41	insulin	Homo sapiens	48-55
28544090-3	2017	AlleyCatE was created by introducing a single-histidine residue (His144 ) into a hydrophobic pocket of calmodulin.	Histidine	46-55	calmodulin 1	Homo sapiens	103-113
28647331-0	2017	Combination of histidine, lysine, methionine, and leucine promotes beta-casein synthesis via the mechanistic target of rapamycin signaling pathway in bovine mammary epithelial cells.	Histidine	15-24	casein beta	Bos taurus	67-78
28647331-4	2017	This study employed response surface methodology to determine the optimal ratio of His, Lys, Met, and Leu on beta-casein expression level in vitro and clarified the effect of the 4 EAA on beta-casein via the mechanistic target of rapamycin (mTOR) signaling pathway.	Histidine	83-86	casein beta	Bos taurus	109-120
28647331-8	2017	The optimum conditions for beta-casein expression are found to be 5.47 mM of His, 7.48 mM of Lys, 1.17 mM of Met, and 8.21 mM of Leu (His:Lys:Met:Leu = 5:6:1:7) in the designed scope of concentration.	Histidine	77-80	casein beta	Bos taurus	27-38
28647331-8	2017	The optimum conditions for beta-casein expression are found to be 5.47 mM of His, 7.48 mM of Lys, 1.17 mM of Met, and 8.21 mM of Leu (His:Lys:Met:Leu = 5:6:1:7) in the designed scope of concentration.	Histidine	134-137	casein beta	Bos taurus	27-38
28647331-15	2017	In conclusion, the extracellular concentrations of His, Lys, Met, and Leu at a ratio of 5:6:1:7 maximized beta-casein expression in the immortalized bovine mammary epithelial cell line may occur via activation of the mechanistic target of rapamycin complex 1 signaling pathway.	Histidine	51-54	casein beta	Bos taurus	106-117
28625912-4	2017	The specific activity of the freshly purified hGAPDH constitutes 117 +- 5 mumol NADH/min per mg protein (pH 9.0, 22  C), which is close to the specific activity of rabbit muscle glyceraldehyde-3-phosphate dehydrogenase determined under the same conditions and several times exceeds the specific activity of his-tagged GAPDH preparations.	Histidine	307-310	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	46-52
28544090-6	2017	Surprisingly, the pKa value of the catalytic histidine inside the hydrophobic pocket of calmodulin is elevated as compared to the model compound pKa value of this residue in water.	Histidine	45-54	calmodulin 1	Homo sapiens	88-98
28676499-7	2017	Replacement of the residues His-936 and His-917 in the activation and catalytic loops, respectively, with alanine dramatically changed PI3Kalpha kinetics.	Histidine	28-31	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	135-144
28630069-6	2017	Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) analysis showed His/Tyr-Ala dipeptide release from the N termini of incretins, glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide, respectively, with the action of microbial DPP4.	Histidine	108-111	glucagon	Homo sapiens	196-201
28630069-6	2017	Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) analysis showed His/Tyr-Ala dipeptide release from the N termini of incretins, glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide, respectively, with the action of microbial DPP4.	Histidine	108-111	gastric inhibitory polypeptide	Homo sapiens	207-251
28676499-7	2017	Replacement of the residues His-936 and His-917 in the activation and catalytic loops, respectively, with alanine dramatically changed PI3Kalpha kinetics.	Histidine	40-43	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	135-144
28763009-2	2017	Orb2 has a glutamine, histidine-rich (Q/H-rich) domain that resembles the Q/H-rich, metal binding domain of the Hpn-like protein (Hpnl) found in Helicobacter pylori.	Histidine	22-31	orb2	Drosophila melanogaster	0-4
28671819-2	2017	Unlike the evolutionarily related proteins hemoglobin and myoglobin, cytoglobin shows a six-coordinated heme binding, with the heme iron coordinated by two histidine side chains.	Histidine	156-165	cytoglobin	Homo sapiens	69-79
28526614-7	2017	Furthermore, over-expression of the fused histidine-tagged ALDH3A1 confers host E. coli cells with enhanced resistance to thermal shock, while ALDH3A1 over-expression in the human corneal cell line HCE-2 was sufficient for protecting them from the cytotoxic effects of both hydrogen peroxide and tert-butyl hydroperoxide.	Histidine	42-51	carboxylesterase 2	Homo sapiens	198-203
28901191-6	2017	The proportions of beta-tubulin- and tyrosine hydroxylase (TH)-positive cells were significantly increased in the HI group compared with the NI and HIR groups, as shown by immunocytochemistry and Western blotting.	Histidine	114-116	tyrosine hydroxylase	Homo sapiens	37-57
28527712-8	2017	It also shows that zinc coordinates to histidine residues in an environment, which is similar to the coordination seen in the insulin R6 hexamers, where three histidine residues and a chloride ion is coordinating the zinc.	Histidine	39-48	insulin	Homo sapiens	126-133
29404483-7	2017	Among these, adipose tissue insulin sensitivity assessed by clamped percent suppression of free fatty acid, serum high molecular weight adiponectin, and plasma tricarboxylic acid cycle metabolites, such as citric acid and cis-aconitic acid, were significantly higher in the high-HIS group compared to the low-HIS group.	Histidine	279-282	insulin	Homo sapiens	28-35
29404483-7	2017	Among these, adipose tissue insulin sensitivity assessed by clamped percent suppression of free fatty acid, serum high molecular weight adiponectin, and plasma tricarboxylic acid cycle metabolites, such as citric acid and cis-aconitic acid, were significantly higher in the high-HIS group compared to the low-HIS group.	Histidine	309-312	insulin	Homo sapiens	28-35
28691797-3	2017	The active site of hHint1 comprises an ensemble of strictly conserved histidines, including nucleophilic His112.	Histidine	70-80	histidine triad nucleotide binding protein 1	Homo sapiens	19-25
28714883-2	2017	The central sequence of alpha-MSH (His-Phe-Arg-Trp) has been identified as being essential for receptor binding.	Histidine	35-38	proopiomelanocortin	Homo sapiens	24-33
28400162-3	2017	Here we expressed the ALOX15 orthologs of eight different mammalian species as well as human ALOX12 and ALOX15B as recombinant his-tag fusion proteins and characterized their reaction specificity with the most abundantly occurring polyunsaturated fatty acids (PUFAs) including 5,8,11,14,17-eicosapentaenoic acid (EPA) and 4,7,10,13,16,19-docosahexaenoic acid (DHA).	Histidine	127-130	arachidonate 15-lipoxygenase	Homo sapiens	22-28
28400162-3	2017	Here we expressed the ALOX15 orthologs of eight different mammalian species as well as human ALOX12 and ALOX15B as recombinant his-tag fusion proteins and characterized their reaction specificity with the most abundantly occurring polyunsaturated fatty acids (PUFAs) including 5,8,11,14,17-eicosapentaenoic acid (EPA) and 4,7,10,13,16,19-docosahexaenoic acid (DHA).	Histidine	127-130	arachidonate 15-lipoxygenase type B	Homo sapiens	104-111
28425671-6	2017	Importantly, the endogenous proteasomal E3 ligase UBE3C was also successfully labelled by Ub-PA and His-UBE2D2-Ub-ABP in lysate of cells grown under basal conditions.	Histidine	100-103	ubiquitin protein ligase E3C	Homo sapiens	50-55
28504656-5	2017	We report that polyplexes made with a histidinylated derivative of lPEI (His-lPEI) exhibit the highest capacity (10.5 mug cm-2 h versus 0.324 mug cm-2 h) to cross TNF-alpha-induced inflamed endothelium model, but this positive effect is counterbalanced by the presence of IL-1beta.	Histidine	73-76	tumor necrosis factor	Mus musculus	163-172
28504656-5	2017	We report that polyplexes made with a histidinylated derivative of lPEI (His-lPEI) exhibit the highest capacity (10.5 mug cm-2 h versus 0.324 mug cm-2 h) to cross TNF-alpha-induced inflamed endothelium model, but this positive effect is counterbalanced by the presence of IL-1beta.	Histidine	73-76	interleukin 1 beta	Mus musculus	272-280
28508285-6	2017	Reactions between HNO3 and histidine residues in AI and AII resulted in the formation of dominant [MAI-H+(HNO3)]- and [MAII-H+(HNO3)]- ions.	Histidine	27-36	angiotensinogen	Homo sapiens	56-59
28527712-8	2017	It also shows that zinc coordinates to histidine residues in an environment, which is similar to the coordination seen in the insulin R6 hexamers, where three histidine residues and a chloride ion is coordinating the zinc.	Histidine	159-168	insulin	Homo sapiens	126-133
28487257-0	2017	Functional efficacy of human recombinant FGF-2s tagged with (His)6 and (His-Asn)6 at the N- and C-termini in human gingival fibroblast and periodontal ligament-derived cells.	Histidine	61-64	fibroblast growth factor 2	Homo sapiens	41-46
28249301-4	2017	Commassie-stained SDS-PAGE gels of His-tag column eluates, concentrated using a 10 000 molecular weight cut-off column, showed an intense band at the expected molecular weight for recombinant human acidic fibroblast growth factor.	Histidine	35-38	fibroblast growth factor 1	Homo sapiens	198-229
28487257-0	2017	Functional efficacy of human recombinant FGF-2s tagged with (His)6 and (His-Asn)6 at the N- and C-termini in human gingival fibroblast and periodontal ligament-derived cells.	Histidine	72-75	fibroblast growth factor 2	Homo sapiens	41-46
28644885-4	2017	We transiently transfected OATP1B3 with a C-terminal His-, FLAG- or HA-tag in HEK293 cells and used co-immunoprecipitation and a Proximity Ligation Assay to detect interactions between the different constructs.	Histidine	53-56	solute carrier organic anion transporter family member 1B3	Homo sapiens	27-34
28644885-10	2017	In addition, we also detected OATP1B3-FLAG co-localization with OATP1B1-His or NTCP-His, suggesting that OATP1B3 also hetero-oligomerizes with other transport proteins.	Histidine	72-75	solute carrier organic anion transporter family member 1B3	Homo sapiens	30-37
28644885-10	2017	In addition, we also detected OATP1B3-FLAG co-localization with OATP1B1-His or NTCP-His, suggesting that OATP1B3 also hetero-oligomerizes with other transport proteins.	Histidine	72-75	solute carrier organic anion transporter family member 1B3	Homo sapiens	105-112
28433433-6	2017	In particular, histidine-scanning mutagenesis performed on three lead sequences yielded the discovery of variants whose EPO-binding is more pH-sensitive, which facilitates EPO recovery.	Histidine	15-24	erythropoietin	Homo sapiens	120-123
28593945-5	2017	Relative to LACC1 Ile254, cells transfected with Crohn"s disease-risk LACC1 Val254 or LACC1 with mutations of the nearby histidines (249,250) have reduced PRR-induced outcomes.	Histidine	121-131	laccase domain containing 1	Homo sapiens	70-75
28593945-5	2017	Relative to LACC1 Ile254, cells transfected with Crohn"s disease-risk LACC1 Val254 or LACC1 with mutations of the nearby histidines (249,250) have reduced PRR-induced outcomes.	Histidine	121-131	laccase domain containing 1	Homo sapiens	70-75
28433433-6	2017	In particular, histidine-scanning mutagenesis performed on three lead sequences yielded the discovery of variants whose EPO-binding is more pH-sensitive, which facilitates EPO recovery.	Histidine	15-24	erythropoietin	Homo sapiens	172-175
28237651-10	2017	In summary, rat GIP(3-30)NH2 is a high affinity competitive GIPR antagonist and effectively antagonizes GIP-mediated G protein-signaling as well as pancreatic hormone release, while human GIP(3-30)NH2, despite a difference of only one amino acid between the two (arginine in position 18 in rat GIP(3-30)NH2; histidine in human), is unsuitable in the rat system.	Histidine	308-317	gastric inhibitory polypeptide	Rattus norvegicus	16-19
28339746-5	2017	The ACE-inhibitory activity was determined using the cleavage of a chromogenic substrate -Hip-His-Leu.	Histidine	94-97	angiotensin I converting enzyme	Homo sapiens	4-7
28319815-4	2017	Bivalent cobalt ions were coupled to the carboxyls on the surface of the obtained Co3O4 NHs so as to chelate the hexahistidine residues (His-Tags) at the C-terminal of EGFR single-domain antibodies (EGFR sdAbs).	Histidine	137-140	epidermal growth factor receptor	Homo sapiens	168-172
28319815-4	2017	Bivalent cobalt ions were coupled to the carboxyls on the surface of the obtained Co3O4 NHs so as to chelate the hexahistidine residues (His-Tags) at the C-terminal of EGFR single-domain antibodies (EGFR sdAbs).	Histidine	137-140	epidermal growth factor receptor	Homo sapiens	199-203
28588751-7	2017	After the high protein meal there was a marked increase in the levels of most amino acids, but only small changes occurred in the levels of taurine, citrulline, cysteine and histidine.The BCAA/AAA ratio was significantly higher 180 and 240 min after the meal.	Histidine	174-183	AT-rich interaction domain 4B	Homo sapiens	188-192
28409923-0	2017	The Catalase Activity of Catalase-Peroxidases Is Modulated by Changes in the pKa of the Distal Histidine.	Histidine	95-104	catalase	Homo sapiens	4-12
28409923-0	2017	The Catalase Activity of Catalase-Peroxidases Is Modulated by Changes in the pKa of the Distal Histidine.	Histidine	95-104	catalase	Homo sapiens	25-33
28202352-11	2017	We found that SLC38A3 decreased the cellular concentrations of glutamine and histidine, and the deficiency of glutamine or histidine activated PDK1/AKT signaling that in turn, triggered NSCLC metastasis.	Histidine	77-86	solute carrier family 38 member 3	Homo sapiens	14-21
28202352-11	2017	We found that SLC38A3 decreased the cellular concentrations of glutamine and histidine, and the deficiency of glutamine or histidine activated PDK1/AKT signaling that in turn, triggered NSCLC metastasis.	Histidine	123-132	AKT serine/threonine kinase 1	Homo sapiens	148-151
28202352-12	2017	CONCLUSIONS: SLC38A3 activated PDK1/AKT signaling and promoted metastasis of NSCLC through regulating glutamine and histidine transport, suggesting SLC38A3 as a potential therapeutic target for treatment of NSCLC.	Histidine	116-125	solute carrier family 38 member 3	Homo sapiens	13-20
28512575-1	2017	Multiple possibilities for the coordination of fac-[Re(CO)3(H2O)3]+ to a protein have been determined and include binding to Asp, Glu, Arg and His amino-acid residues as well as to the C-terminal carboxylate in the vicinity of Leu and Pro.	Histidine	143-146	FA complementation group C	Homo sapiens	47-50
28373561-11	2017	We propose that the protonation states of the essential histidines regulate the ERp44-client interaction by altering the C-tail dynamics and surface electrostatic potential of ERp44.	Histidine	56-66	endoplasmic reticulum protein 44	Homo sapiens	80-85
28373561-11	2017	We propose that the protonation states of the essential histidines regulate the ERp44-client interaction by altering the C-tail dynamics and surface electrostatic potential of ERp44.	Histidine	56-66	endoplasmic reticulum protein 44	Homo sapiens	176-181
28320390-5	2017	PCR was used to determine whether deletions of the histidine-rich central repeat region of the hrp2 gene (exon 2) were associated with false-negative HRP2-based RDTs.	Histidine	51-60	HDGF like 2	Homo sapiens	95-99
28320390-5	2017	PCR was used to determine whether deletions of the histidine-rich central repeat region of the hrp2 gene (exon 2) were associated with false-negative HRP2-based RDTs.	Histidine	51-60	HDGF like 2	Homo sapiens	150-154
28245560-2	2017	Ubiquitin-specific protease 15 (USP15), a member of the largest subfamily of cysteine protease DUBs, contains two conservative cysteine (Cys) and histidine (His) boxes.	Histidine	146-155	ubiquitin specific peptidase 15	Homo sapiens	0-30
28196881-1	2017	Attachment is catalyzed by holocytochrome c synthase (HCCS), leading to two thioether bonds between heme and a conserved CXXCH motif of cyt c In cyt c, histidine (His19) of CXXCH acts as an axial ligand to heme iron and upon release of holocytochrome c from HCCS, folding leads to formation of a second axial interaction with methionine (Met81).	Histidine	152-161	holocytochrome c synthase	Homo sapiens	27-52
28196881-1	2017	Attachment is catalyzed by holocytochrome c synthase (HCCS), leading to two thioether bonds between heme and a conserved CXXCH motif of cyt c In cyt c, histidine (His19) of CXXCH acts as an axial ligand to heme iron and upon release of holocytochrome c from HCCS, folding leads to formation of a second axial interaction with methionine (Met81).	Histidine	152-161	holocytochrome c synthase	Homo sapiens	54-58
28196881-1	2017	Attachment is catalyzed by holocytochrome c synthase (HCCS), leading to two thioether bonds between heme and a conserved CXXCH motif of cyt c In cyt c, histidine (His19) of CXXCH acts as an axial ligand to heme iron and upon release of holocytochrome c from HCCS, folding leads to formation of a second axial interaction with methionine (Met81).	Histidine	152-161	cytochrome c, somatic	Homo sapiens	136-141
28196881-1	2017	Attachment is catalyzed by holocytochrome c synthase (HCCS), leading to two thioether bonds between heme and a conserved CXXCH motif of cyt c In cyt c, histidine (His19) of CXXCH acts as an axial ligand to heme iron and upon release of holocytochrome c from HCCS, folding leads to formation of a second axial interaction with methionine (Met81).	Histidine	152-161	holocytochrome c synthase	Homo sapiens	258-262
28292182-6	2017	Furthermore, (epsilondeltadelta) may be the easiest one to overcome structural transformation due to nonobstructing interactions between K16 and/or L17 and histidine residues.	Histidine	156-165	ribosomal protein L17	Homo sapiens	148-151
28100618-10	2017	Our results raise the intriguing possibility that the presence of His 375 in the circulating strain where the RV144 trial was held contributed to the observed vaccine efficacy.IMPORTANCE HIV-1-infected cells presenting Env in the CD4-bound conformation on their surface are preferentially targeted by ADCC mediated by HIV-positive (HIV+) sera.	Histidine	66-69	CD4 molecule	Homo sapiens	230-233
28096459-6	2017	We further demonstrate that the APP-C99 histidine residues His-6, His-13, and His-14 control the Zn2+-dependent APP-C99 dimerization and inhibition of Abeta production, whereas the increased Abeta43:Abeta40 ratio is substrate dimerization-independent and involves the known Zn2+ binding lysine Lys-28 residue that orientates the APP-C99 transmembrane domain within the lipid bilayer.	Histidine	40-49	amyloid beta precursor protein	Homo sapiens	151-156
28096459-6	2017	We further demonstrate that the APP-C99 histidine residues His-6, His-13, and His-14 control the Zn2+-dependent APP-C99 dimerization and inhibition of Abeta production, whereas the increased Abeta43:Abeta40 ratio is substrate dimerization-independent and involves the known Zn2+ binding lysine Lys-28 residue that orientates the APP-C99 transmembrane domain within the lipid bilayer.	Histidine	59-62	amyloid beta precursor protein	Homo sapiens	151-156
28096459-6	2017	We further demonstrate that the APP-C99 histidine residues His-6, His-13, and His-14 control the Zn2+-dependent APP-C99 dimerization and inhibition of Abeta production, whereas the increased Abeta43:Abeta40 ratio is substrate dimerization-independent and involves the known Zn2+ binding lysine Lys-28 residue that orientates the APP-C99 transmembrane domain within the lipid bilayer.	Histidine	66-69	amyloid beta precursor protein	Homo sapiens	151-156
28096459-6	2017	We further demonstrate that the APP-C99 histidine residues His-6, His-13, and His-14 control the Zn2+-dependent APP-C99 dimerization and inhibition of Abeta production, whereas the increased Abeta43:Abeta40 ratio is substrate dimerization-independent and involves the known Zn2+ binding lysine Lys-28 residue that orientates the APP-C99 transmembrane domain within the lipid bilayer.	Histidine	66-69	amyloid beta precursor protein	Homo sapiens	151-156
28245560-2	2017	Ubiquitin-specific protease 15 (USP15), a member of the largest subfamily of cysteine protease DUBs, contains two conservative cysteine (Cys) and histidine (His) boxes.	Histidine	146-155	ubiquitin specific peptidase 15	Homo sapiens	32-37
28245560-2	2017	Ubiquitin-specific protease 15 (USP15), a member of the largest subfamily of cysteine protease DUBs, contains two conservative cysteine (Cys) and histidine (His) boxes.	Histidine	157-160	ubiquitin specific peptidase 15	Homo sapiens	0-30
28245560-2	2017	Ubiquitin-specific protease 15 (USP15), a member of the largest subfamily of cysteine protease DUBs, contains two conservative cysteine (Cys) and histidine (His) boxes.	Histidine	157-160	ubiquitin specific peptidase 15	Homo sapiens	32-37
28032976-3	2017	Unlike pentacoordinate flavohemoglobins, which are efficient NODs, THB1 uses two iron axial ligands: the conserved proximal histidine and a distal lysine (Lys53).	Histidine	124-133	uncharacterized protein	Chlamydomonas reinhardtii	67-71
28382155-3	2017	Lactam bridge-cyclized alpha-melanocyte-stimulating hormone (Ac-Nle4-cyclo[Asp5-His-D-Phe7-Arg-Trp-Lys10]-NH2, or Nle-CycMSHhex) analogues have been successfully developed and studied for MC1R-targeted imaging, predominantly with single-photon emission computed tomography (SPECT).	Histidine	80-83	melanocortin 1 receptor	Mus musculus	188-192
28045525-4	2017	The tetrapeptide His-DPhe-Arg-Trp or tripeptide DPhe-Arg-Trp replaced the Arg-Phe-Phe sequence in the AGRP active loop derivative c[Pro-Arg-Phe-Phe-Xxx-Ala-Phe-DPro], where Xxx was the native Asn of AGRP or a diaminopropionic (Dap) acid residue previously shown to increase antagonist potency at the mMC4R.	Histidine	17-20	agouti related neuropeptide	Mus musculus	102-106
28088197-8	2017	The methanol inducible promoter AOX1 was used to drive expression of the native and histidine tagged forms of pro-relaxin H2 in dual phase fed-batch experiments on the 22 L scale.	Histidine	84-93	aldehyde oxidase 1	Homo sapiens	32-36
27845049-0	2017	A novel role for PHT1 in the disposition of l-histidine in brain: In vitro slice and in vivo pharmacokinetic studies in wildtype and Pht1 null mice.	Histidine	44-55	solute carrier family 15, member 4	Mus musculus	17-21
27845049-1	2017	PHT1 (SLC15A4) is responsible for translocating l-histidine (l-His), di/tripeptides and peptide-like drugs across biological membranes.	Histidine	48-59	solute carrier family 15, member 4	Mus musculus	0-4
27845049-1	2017	PHT1 (SLC15A4) is responsible for translocating l-histidine (l-His), di/tripeptides and peptide-like drugs across biological membranes.	Histidine	48-59	solute carrier family 15, member 4	Mus musculus	6-13
27845049-1	2017	PHT1 (SLC15A4) is responsible for translocating l-histidine (l-His), di/tripeptides and peptide-like drugs across biological membranes.	Histidine	61-66	solute carrier family 15, member 4	Mus musculus	0-4
27845049-1	2017	PHT1 (SLC15A4) is responsible for translocating l-histidine (l-His), di/tripeptides and peptide-like drugs across biological membranes.	Histidine	61-66	solute carrier family 15, member 4	Mus musculus	6-13
27845049-3	2017	In this study, adult gender-matched Pht1-competent (wildtype) and Pht1-deficient (null) mice were used to investigate the effect of PHT1 on l-His brain disposition via in vitro slice and in vivo pharmacokinetic approaches.	Histidine	140-145	solute carrier family 15, member 4	Mus musculus	132-136
27845049-7	2017	The uptake of l-His was reduced in brain slices by 50% during PHT1 ablation.	Histidine	14-19	solute carrier family 15, member 4	Mus musculus	62-66
27845049-10	2017	Still, biodistribution studies revealed that, when sampled 5min after dosing, l-His values were 28-48% lower in Pht1 null mice, as compared to wildtype animals, in brain parenchyma but not cerebrospinal fluid.	Histidine	78-83	solute carrier family 15, member 4	Mus musculus	112-116
27845049-11	2017	These findings suggest that PHT1 may play an important role in histidine transport in brain, and resultant effects on histidine/histamine homeostasis and neuropeptide regulation.	Histidine	63-72	solute carrier family 15, member 4	Mus musculus	28-32
27845049-11	2017	These findings suggest that PHT1 may play an important role in histidine transport in brain, and resultant effects on histidine/histamine homeostasis and neuropeptide regulation.	Histidine	118-127	solute carrier family 15, member 4	Mus musculus	28-32
28223859-4	2017	They have histidine rich amino acid sequences (7-12 family members; corresponding to residues 12-24, 13-24, 12-25, 13-25, 5-11, and 5-12, respectively) for Histatin-3.	Histidine	10-19	histatin 3	Homo sapiens	156-166
27895119-8	2017	We also showed that replacing the phenylalanine 3.33 in CCR5 TM3 by the corresponding histidine of CCR2 converts J113863 from an antagonist for cell migration and a partial agonist in other assays to a full agonist in all assays.	Histidine	86-95	C-C motif chemokine receptor 2	Homo sapiens	99-103
29214080-2	2017	As a member of the histidine triad (HIT) enzyme superfamily, HINT1 is distributed in almost every organ and has both enzymatic and nonenzymatic activity.	Histidine	19-28	histidine triad nucleotide binding protein 1	Homo sapiens	61-66
27694446-8	2016	The dramatic repositioning is influenced by a differential ability to establish stable face-to-face pi-pi-stacking with the LRH-1 residue His-390, as well as by a novel polar interaction mediated by the RJW100 hydroxyl group.	Histidine	138-141	nuclear receptor subfamily 5 group A member 2	Homo sapiens	124-129
27735058-1	2016	The C-terminal domain (CTD) of tumor suppressor protein p53 is an intrinsically disordered region that binds to various partner proteins, where lysine of CTD is acetylated/nonacetylated and histidine neutralized/non-neutralized.	Histidine	190-199	tumor protein p53	Homo sapiens	56-59
27859223-3	2016	To test the hypothesis that lipopolysaccharide (LPS) interacts with SePP, we investigated the interaction between LPS and the histidine-rich (His-rich) regions of SePP.	Histidine	142-145	selenoprotein P	Homo sapiens	163-167
27859223-4	2016	We demonstrate that both purified SePP and synthetic peptides corresponding to the His-rich motifs neutralized LPS.	Histidine	83-86	selenoprotein P	Homo sapiens	34-38
27591418-10	2016	Furthermore, the values obtained from the present method were in agreement with the result from isotope dilution quantification using isotopically labeled angiotensin I [Asp-Arg-(Val-d8 )-Tyr-Ile-His-Pro-(Phe-d8 )-His-Leu].	Histidine	196-199	angiotensinogen	Homo sapiens	155-168
27591418-10	2016	Furthermore, the values obtained from the present method were in agreement with the result from isotope dilution quantification using isotopically labeled angiotensin I [Asp-Arg-(Val-d8 )-Tyr-Ile-His-Pro-(Phe-d8 )-His-Leu].	Histidine	214-217	angiotensinogen	Homo sapiens	155-168
27776770-2	2016	In this study, both lysine and histidine are shown to affect the thermal stability of myoglobin, bovine serum albumin, and lysozyme through a combination of mechanisms governed by their respective functional side chains and glycine, similar to arginine.	Histidine	31-40	albumin	Homo sapiens	104-117
27776770-2	2016	In this study, both lysine and histidine are shown to affect the thermal stability of myoglobin, bovine serum albumin, and lysozyme through a combination of mechanisms governed by their respective functional side chains and glycine, similar to arginine.	Histidine	31-40	lysozyme	Homo sapiens	123-131
27750195-13	2016	As well, it was shown that the extra cellular acidosis led to the protonation of the TRAIL residue histidine by flipping the His switch to the on position with a concomitant decrease in affinity for DR4 and DR5 receptors.	Histidine	99-108	TNF superfamily member 10	Homo sapiens	85-90
27934321-3	2016	Herein we present the synthesis and characterization of two ligands HL1 and H2L2 containing a phenanthroline unit (phen) attached to the amino group of histidine (His).	Histidine	152-161	asialoglycoprotein receptor 1	Homo sapiens	68-71
27934321-3	2016	Herein we present the synthesis and characterization of two ligands HL1 and H2L2 containing a phenanthroline unit (phen) attached to the amino group of histidine (His).	Histidine	163-166	asialoglycoprotein receptor 1	Homo sapiens	68-71
27895927-4	2016	Unlike the majority of polyglutamine expansion diseases, the presence of histidine interruptions within the polyglutamine tract of ataxin-1 protein can prevent or mitigate disease.	Histidine	73-82	ataxin 1	Homo sapiens	131-139
27869178-9	2016	We conclude that interactions of nickel ions with histidine residues in domain B help to maintain the conformation of the C-terminal region to conserve the integrity of the HpGroES structure and modulate IL-8 release.	Histidine	50-59	C-X-C motif chemokine ligand 8	Homo sapiens	204-208
27750195-13	2016	As well, it was shown that the extra cellular acidosis led to the protonation of the TRAIL residue histidine by flipping the His switch to the on position with a concomitant decrease in affinity for DR4 and DR5 receptors.	Histidine	125-128	TNF superfamily member 10	Homo sapiens	85-90
27650500-8	2016	These data identify a molecular mechanism for pH-sensitive PI(4,5)P2 binding regulating NHE1 activity and suggest that the evolutionarily conserved cluster of four histidines in the proximal cytoplasmic domain of NHE1 may constitute a proton modifier site.	Histidine	164-174	solute carrier family 9 member A1	Homo sapiens	88-92
27687728-6	2016	We found that the H684R substitution within human Abeta, which replaces the histidine in the human protein with the arginine found at the corresponding position in mouse, facilitated beta" cleavage irrespective of the species origin of BACE1, thereby significantly increasing the level of Abeta(11-XX) and decreasing the level of Abeta(1-XX).	Histidine	76-85	amyloid beta precursor protein	Homo sapiens	50-55
27650500-8	2016	These data identify a molecular mechanism for pH-sensitive PI(4,5)P2 binding regulating NHE1 activity and suggest that the evolutionarily conserved cluster of four histidines in the proximal cytoplasmic domain of NHE1 may constitute a proton modifier site.	Histidine	164-174	solute carrier family 9 member A1	Homo sapiens	213-217
27650500-0	2016	A Histidine Cluster in the Cytoplasmic Domain of the Na-H Exchanger NHE1 Confers pH-sensitive Phospholipid Binding and Regulates Transporter Activity.	Histidine	2-11	solute carrier family 9 member A1	Homo sapiens	68-72
27650500-3	2016	We report that an evolutionarily conserved cluster of histidine residues located in the C-terminal cytoplasmic domain between two phosphatidylinositol 4,5-bisphosphate binding sites (PI(4,5)P2) of NHE1 confers pH-dependent PI(4,5)P2 binding and regulates NHE1 activity.	Histidine	54-63	solute carrier family 9 member A1	Homo sapiens	197-201
27543355-9	2016	[3H]-GlySar and [3H]-l-His uptake receded to approximately 30% in the presence of His-Leu-LPV supporting the PepT1/PHT1 mediated uptake process.	Histidine	21-26	solute carrier family 15 member 1	Homo sapiens	109-114
27650500-3	2016	We report that an evolutionarily conserved cluster of histidine residues located in the C-terminal cytoplasmic domain between two phosphatidylinositol 4,5-bisphosphate binding sites (PI(4,5)P2) of NHE1 confers pH-dependent PI(4,5)P2 binding and regulates NHE1 activity.	Histidine	54-63	solute carrier family 9 member A1	Homo sapiens	255-259
27374664-4	2016	METHODS AND RESULTS: Three Pru p 1 isoforms were cloned and expressed as soluble proteins with His-tags in Escherichia coli.	Histidine	95-98	replication initiation protein	Escherichia coli	31-34
29235833-5	2016	Molecular mass of lipoxygenase is 90 kDa, amino acid composition is distinguished by a high content of glutamic acid, proline, valine, isoleucine, leucine and low level of histidine, tyrosine, phenylalanine, threonine, tryptophan, cystein.	Histidine	172-181	LOC543232	Triticum aestivum	18-30
27543355-9	2016	[3H]-GlySar and [3H]-l-His uptake receded to approximately 30% in the presence of His-Leu-LPV supporting the PepT1/PHT1 mediated uptake process.	Histidine	23-26	solute carrier family 15 member 1	Homo sapiens	109-114
27581177-3	2016	Permeability data showed a significant improvement in insulin permeation especially for 10 mug/mL of lysine (p &lt; 0.05) and 10 mug/mL histidine (p &lt; 0.001), 100 mug/mL of glutamic acid (p &lt; 0.05) and 200 mug/mL of glutamic acid and aspartic acid (p &lt; 0.001) without affecting cell integrity; in contrast to sodium deoxycholate which enhanced insulin permeability but was toxic to the cells.	Histidine	136-145	insulin	Homo sapiens	54-61
27479485-4	2016	The modified DNA efficiently cross-linked with p53 protein through alkylation of cysteine and showed potential for cross-linking with histidine (in C277H mutant of p53).	Histidine	134-143	tumor protein p53	Homo sapiens	47-50
27479485-4	2016	The modified DNA efficiently cross-linked with p53 protein through alkylation of cysteine and showed potential for cross-linking with histidine (in C277H mutant of p53).	Histidine	134-143	tumor protein p53	Homo sapiens	164-167
27382069-7	2016	We also identify an 11 Histidine repeat and the homeodomain of HOXA1 to be required both for RBCK1 and TRAF2 interaction and NF-kappaB stimulation.	Histidine	23-32	RANBP2-type and C3HC4-type zinc finger containing 1	Homo sapiens	93-98
27382069-7	2016	We also identify an 11 Histidine repeat and the homeodomain of HOXA1 to be required both for RBCK1 and TRAF2 interaction and NF-kappaB stimulation.	Histidine	23-32	nuclear factor kappa B subunit 1	Homo sapiens	125-134
27795879-4	2016	Due to the presence of His-tag sequence on the N-terminal side, Rab3A fusion protein was purified to greater than 95 % purity with a single Ni-affinity purification step.	Histidine	23-26	RAB3A, member RAS oncogene family	Rattus norvegicus	64-69
27601274-4	2016	Histidine-tag pull-down assay using purified p53(1-393)-His and G-actin confirms direct physical association between p53 and monomeric G-actin.	Histidine	0-9	tumor protein p53	Homo sapiens	45-48
27601274-4	2016	Histidine-tag pull-down assay using purified p53(1-393)-His and G-actin confirms direct physical association between p53 and monomeric G-actin.	Histidine	0-9	tumor protein p53	Homo sapiens	117-120
27601274-4	2016	Histidine-tag pull-down assay using purified p53(1-393)-His and G-actin confirms direct physical association between p53 and monomeric G-actin.	Histidine	0-3	tumor protein p53	Homo sapiens	45-48
27601274-4	2016	Histidine-tag pull-down assay using purified p53(1-393)-His and G-actin confirms direct physical association between p53 and monomeric G-actin.	Histidine	0-3	tumor protein p53	Homo sapiens	117-120
27542194-6	2016	Furthermore, we show that activated CD4(+) T cells deficient in intracellular copper exhibit increased KCa3.1 histidine phosphorylation and channel activity, leading to increased calcium flux and cytokine production.	Histidine	110-119	CD4 molecule	Homo sapiens	36-39
27247265-3	2016	Previous in vitro studies revealed that palmitoylation of NCAM is required for fibroblast growth factor 2 (FGF2)-stimulated neurite outgrowth and identified the zinc finger DHHC (Asp-His-His-Cys)-containing proteins ZDHHC3 and ZDHHC7 as specific NCAM-palmitoylating enzymes.	Histidine	183-186	fibroblast growth factor 2	Homo sapiens	79-105
27247265-3	2016	Previous in vitro studies revealed that palmitoylation of NCAM is required for fibroblast growth factor 2 (FGF2)-stimulated neurite outgrowth and identified the zinc finger DHHC (Asp-His-His-Cys)-containing proteins ZDHHC3 and ZDHHC7 as specific NCAM-palmitoylating enzymes.	Histidine	187-190	fibroblast growth factor 2	Homo sapiens	79-105
27098584-13	2016	The AR gene in KUCaP3 cells contained a substitution from CAT (histidine) to TAT (tyrosine) at the nucleotide positions corresponding to codon 875 (H875Y) in the ligand-binding domain.	Histidine	63-72	androgen receptor	Homo sapiens	4-6
27316830-4	2016	An affinity tag comprised of a proline, a glycine and eight histidines was introduced into the C-terminal end of hPGHS-2.	Histidine	60-70	prostaglandin-endoperoxide synthase 2	Homo sapiens	113-120
27453048-3	2016	By dephosphorylating NDPK-B, PGAM5 negatively regulates CD4(+) T cells by inhibiting NDPK-B-mediated histidine phosphorylation and activation of the K(+) channel KCa3.1, which is required for TCR-stimulated Ca(2+) influx and cytokine production.	Histidine	101-110	CD4 molecule	Homo sapiens	56-59
27226609-4	2016	A domain swapping and substitution analysis between hZnT10 and the zinc-specific transporter hZnT1 showed that residue Asn(43), which corresponds to the His residue constituting the potential intramembranous zinc coordination site in other ZnT transporters, is necessary to impart hZnT10"s unique manganese mobilization activity; residues Cys(52) and Leu(242) in transmembrane domains II and V play a subtler role in controlling the metal specificity of hZnT10.	Histidine	153-156	solute carrier family 30 member 10	Homo sapiens	52-58
27420328-3	2016	The tandem repeats of the Cysteine-Glycine-Histidine (CGH) metal ion binding motif exhibited concerted binding to Co(II) ions, suggesting that conformational transition of peptide was triggered by the sequential metal ion binding.	Histidine	43-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-120
27307044-7	2016	In SLC30A10, the corresponding residues are Asn-43 and Asp-47 in the second and His-244 and Asp-248 in the fifth transmembrane segments.	Histidine	80-83	solute carrier family 30 member 10	Homo sapiens	3-11
27409634-10	2016	In conclusion, higher dietary histidine is inversely associated with energy intake, status of insulin resistance, inflammation and oxidative stress in overweight/obese participants and lower prevalence of overweight/obesity in northern Chinese adults.	Histidine	30-39	insulin	Homo sapiens	94-101
27226609-4	2016	A domain swapping and substitution analysis between hZnT10 and the zinc-specific transporter hZnT1 showed that residue Asn(43), which corresponds to the His residue constituting the potential intramembranous zinc coordination site in other ZnT transporters, is necessary to impart hZnT10"s unique manganese mobilization activity; residues Cys(52) and Leu(242) in transmembrane domains II and V play a subtler role in controlling the metal specificity of hZnT10.	Histidine	153-156	solute carrier family 30 member 1	Homo sapiens	52-57
27226609-4	2016	A domain swapping and substitution analysis between hZnT10 and the zinc-specific transporter hZnT1 showed that residue Asn(43), which corresponds to the His residue constituting the potential intramembranous zinc coordination site in other ZnT transporters, is necessary to impart hZnT10"s unique manganese mobilization activity; residues Cys(52) and Leu(242) in transmembrane domains II and V play a subtler role in controlling the metal specificity of hZnT10.	Histidine	153-156	solute carrier family 30 member 10	Homo sapiens	281-287
27226609-4	2016	A domain swapping and substitution analysis between hZnT10 and the zinc-specific transporter hZnT1 showed that residue Asn(43), which corresponds to the His residue constituting the potential intramembranous zinc coordination site in other ZnT transporters, is necessary to impart hZnT10"s unique manganese mobilization activity; residues Cys(52) and Leu(242) in transmembrane domains II and V play a subtler role in controlling the metal specificity of hZnT10.	Histidine	153-156	solute carrier family 30 member 10	Homo sapiens	281-287
26999302-7	2016	Positional scanning peptide library analysis revealed a unique substrate specificity of the ZAK kinase including unprecedented preferences for histidine residues at positions -1 and +2 relative to the phosphoacceptor site.	Histidine	143-152	mitogen-activated protein kinase kinase kinase 20	Homo sapiens	92-95
26954163-10	2016	Maximum concentrations of isoleucine, phenylalanine, and histidine were noticed in goat milk caseins.	Histidine	57-66	Weaning weight-maternal milk	Bos taurus	88-92
27296367-5	2016	In this study, we mutate this arginine to a histidine in the human glutamate transporter EAAT1 and investigate the role of the protonation state of this residue on anion selectivity and transporter function.	Histidine	44-53	solute carrier family 1 member 3	Homo sapiens	89-94
27332127-6	2016	The substitution of hydrophobic Ala with His or Arg in the central region of the EDEM1 or SPAST peptides, respectively, attenuated their ability to flip phospholipids.	Histidine	41-44	ER degradation enhancing alpha-mannosidase like protein 1	Homo sapiens	81-86
27332127-9	2016	The EDEM1 peptide exhibited high activity at significantly low peptide concentrations, suggesting that the same side positioning of Arg and His in alpha-helix structure is critical for the flip-flop promotion and that the EDEM1 protein is a candidate flippase in the ER.	Histidine	140-143	ER degradation enhancing alpha-mannosidase like protein 1	Homo sapiens	4-9
27143361-2	2016	Ctr1 is a high affinity Cu(+) transporter on the plasma membrane and endosomes that exists as a full-length protein and a truncated form of Ctr1 lacking the methionine- and histidine-rich metal-binding ectodomain, and it exhibits reduced Cu(+) transport activity.	Histidine	173-182	solute carrier family 31, member 1	Mus musculus	0-4
26928127-3	2016	YPQ1 and AVT1, which are involved in the vacuolar uptake of lysine/arginine and histidine, respectively, were deleted in addition to ypq2Delta and ypq3Delta.	Histidine	80-89	Avt1p	Saccharomyces cerevisiae S288C	9-13
27342775-17	2016	In addition, histidine treatment initiated immediately, but not 3 days after PSL, inhibited microglial activation and IL-1beta upregulation in the lumbar spinal cord, in parallel with its effects on behavioral hypersensitivity.	Histidine	13-22	interleukin 1 beta	Rattus norvegicus	118-126
26826591-5	2016	We find here, however, that the formation of the S3 state is coupled to the movement of a calcium-bound hydroxide (W3) from the Ca to a Mn (Mn1 or Mn4) in a process that is triggered by the formation of a tyrosyl radical (Tyr-161) and its protonated base, His-190.	Histidine	256-259	MN1 proto-oncogene, transcriptional regulator	Homo sapiens	140-143
26926590-1	2016	A TRAIL-CM4 fusion protein in soluble form with tumor selective apoptosis and antibacterial functions was expressed in the Escherichia coli expression system and isolated through dialysis refolding and histidine-tag Nickel-affinity purification.	Histidine	202-211	TNF superfamily member 10	Homo sapiens	2-7
27251136-11	2016	CONCLUSIONS: Our structures of Zn(2+)/Ca(2+)-bound hS100A8 demonstrate that S100A8 is a genuine His-Zn S100 protein.	Histidine	96-99	S100 calcium binding protein B	Homo sapiens	52-56
27272775-8	2016	Histidine, a well-known reactive oxygen scavenger, significantly inhibited sonodynamically-induced apoptosis, caspase-3 activation and 4oxoTEMPO formation.	Histidine	0-9	caspase 3	Homo sapiens	110-119
27221710-4	2016	We found that synthetic monomeric Abeta40 bound through its RHDS (Arg-His-Asp-Ser) sequence to integrin alphaIIbbeta3, which is the receptor for the extracellular matrix protein fibrinogen, and stimulated the secretion of adenosine diphosphate (ADP) and the chaperone protein clusterin from platelets.	Histidine	70-73	fibrinogen beta chain	Homo sapiens	178-188
27433338-6	2016	Milling of the lyophilized IgG2 M428L FcRn-binding variant after formulation in 10 mmol/L histidine, pH 5.7, 8.5% sucrose, 0.04% PS80 did not alter the physicochemical properties nor the molecular integrity compared to the batch released in PBS.	Histidine	90-99	Fc gamma receptor and transporter	Homo sapiens	38-42
27031609-4	2016	The assay was adapted to the high-throughput screening (HTS) format and its utility was demonstrated by screening an "in-house" library of small nucleotides against two enzymes: DcpS, a metal-independent mRNA decapping pyrophosphatase of the histidine triad (HIT) family; and PDE-I, a divalent cation-dependent nuclease.	Histidine	242-251	decapping enzyme, scavenger	Homo sapiens	178-182
26843094-6	2016	Experiments with deletion and point mutants of hTREK1 channel suggest that lactate changes the pH modulation of hTREK1 by interacting differently with the histidine residue at 328th position (H328) above and below its pKa (~6.0) in the intracellular carboxyl-terminal domain of TREK1.	Histidine	155-164	potassium two pore domain channel subfamily K member 2	Homo sapiens	47-53
26843094-6	2016	Experiments with deletion and point mutants of hTREK1 channel suggest that lactate changes the pH modulation of hTREK1 by interacting differently with the histidine residue at 328th position (H328) above and below its pKa (~6.0) in the intracellular carboxyl-terminal domain of TREK1.	Histidine	155-164	potassium two pore domain channel subfamily K member 2	Homo sapiens	112-118
26843094-6	2016	Experiments with deletion and point mutants of hTREK1 channel suggest that lactate changes the pH modulation of hTREK1 by interacting differently with the histidine residue at 328th position (H328) above and below its pKa (~6.0) in the intracellular carboxyl-terminal domain of TREK1.	Histidine	155-164	potassium two pore domain channel subfamily K member 2	Homo sapiens	48-53
26792558-4	2016	The functionality and validity of the nickel magnetic nanoparticles were attested by purification of three different bioactive His-tagged recombinant fusion proteins including hIGF-1, GM-CSF and bFGF.	Histidine	127-130	insulin like growth factor 1	Homo sapiens	176-182
26792558-4	2016	The functionality and validity of the nickel magnetic nanoparticles were attested by purification of three different bioactive His-tagged recombinant fusion proteins including hIGF-1, GM-CSF and bFGF.	Histidine	127-130	fibroblast growth factor 2	Homo sapiens	195-199
26780704-8	2016	When the sites in the interface is saturated, SDS interacts with VAL 73, HIS 74, ASN 147 and PHE 152, the key residues of the enzyme activity, and leads to the decrease of CAT activity.	Histidine	73-76	catalase	Mus musculus	172-175
27060305-9	2016	DNA sequencing has confirmed that the proband, his mother, brother, and nephew have all carried a g.5877G&gt;A mutation in the exon 8 of the FGG gene, which resulted in replacement of arginine (Arg) by histidine (His) at position 275.	Histidine	202-211	fibrinogen gamma chain	Homo sapiens	141-144
27035963-9	2016	Modeling based on recent crystal structures, along with mutational analysis, suggests that each subunit within a TREK1-TREK2 channel is regulated independently via titratable His.	Histidine	175-178	potassium two pore domain channel subfamily K member 2	Homo sapiens	113-118
27058169-7	2016	The HAESA co-receptor SERK1, a positive regulator of the floral abscission pathway, allows for high-affinity sensing of the peptide hormone by binding to an Arg-His-Asn motif in IDA.	Histidine	161-164	mitogen-activated protein kinase kinase 4	Homo sapiens	22-27
27060305-9	2016	DNA sequencing has confirmed that the proband, his mother, brother, and nephew have all carried a g.5877G&gt;A mutation in the exon 8 of the FGG gene, which resulted in replacement of arginine (Arg) by histidine (His) at position 275.	Histidine	213-216	fibrinogen gamma chain	Homo sapiens	141-144
26867113-2	2016	Glycine (Gly), glutamic acid (Glu), and histidine (His) with different isoelectric points were chosen as representative amino acid candidates to synthesize corresponding amino acid-DTC compounds through mixing with carbon disulfide (CS2), respectively.	Histidine	51-54	chorionic somatomammotropin hormone 2	Homo sapiens	233-236
27042204-1	2016	BACKGROUND: Heteroligand Co(II) complexes involving imidazole and selected bio-relevant L-alpha-amino acids of four different groups (aspartic acid, lysine, histidine and asparagine) were formed by using a polymeric, pseudo-tetrahedral, semi-conductive Co(II) complex with imidazole-[Co(imid)2]n as starting material.	Histidine	157-166	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-31
27042204-1	2016	BACKGROUND: Heteroligand Co(II) complexes involving imidazole and selected bio-relevant L-alpha-amino acids of four different groups (aspartic acid, lysine, histidine and asparagine) were formed by using a polymeric, pseudo-tetrahedral, semi-conductive Co(II) complex with imidazole-[Co(imid)2]n as starting material.	Histidine	157-166	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	253-259
26739061-3	2016	In the present study, exposure of MCF-7 breast cancer cells to HIS and the H1 receptor antagonist AST both alone and together with HIS (AST-HIS) led to generation of intracellular ROS, which induced massive cellular vacuolization through dilation of the ER and mitochondria.	Histidine	63-66	solute carrier family 17 member 5	Homo sapiens	136-139
26739061-5	2016	In addition, AST-HIS caused ER stress-induced autophagy in MCF-7 cells, as evidenced by an increased LC3-II/LC3-I ratio, with surprisingly no changes in Beclin-1 expression.	Histidine	17-20	solute carrier family 17 member 5	Homo sapiens	13-16
26739061-8	2016	In conclusion, these findings indicate that AST-HIS-induced apoptosis and autophagy can be regulated by ROS-mediated signaling pathways.	Histidine	48-51	solute carrier family 17 member 5	Homo sapiens	44-47
26869430-1	2016	The aim of this study is to evaluate the effect of peptide cyclization on the blood-brain barrier (BBB) modulatory activity and plasma stability of His-Ala-Val peptides, which are derived from the extracellular 1 domain of human E-cadherin.	Histidine	148-151	cadherin 1	Homo sapiens	229-239
26833727-6	2016	The consensus C:G base pairs H-bond with conserved His or Arg residues in ZnF8, ZnF9, and ZnF11, and the consensus T:A base pair H-bonds with an Asn that replaces His in ZnF10.	Histidine	163-166	zinc finger protein 10	Homo sapiens	170-175
26856188-0	2016	Tc-99m Glu-Cys-Gly-His-Gly-Lys (ECG-HGK), a novel Tc-99m labeled hexapeptide for molecular tumor imaging.	Histidine	19-22	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	36-39
26858457-4	2016	In ECs transiently transfected with pcDNA3.1-myc-His-Phe(99)-CaM, but not in ECs transfected with pcDNA3.1-myc-His-Phe(138)-CaM, the lysoPC-induced TRPC6-CaM dissociation and TRPC6 externalization was disrupted.	Histidine	49-52	calmodulin 1	Homo sapiens	61-64
26858457-5	2016	Also, the lysoPC-induced increase in intracellular calcium concentration was inhibited in ECs transiently transfected with pcDNA3.1-myc-His-Phe(99)-CaM.	Histidine	136-139	calmodulin 1	Homo sapiens	148-151
26791423-5	2016	His residues constructing the Cu(2+)-binding site in denatured apo-H43R were experimentally assigned by absorption and fluorescence-based assays of SOD1 mutants, in which each of the seven His residues in H43R SOD1 is replaced with Ala.	Histidine	0-3	superoxide dismutase 1	Homo sapiens	148-152
26791423-5	2016	His residues constructing the Cu(2+)-binding site in denatured apo-H43R were experimentally assigned by absorption and fluorescence-based assays of SOD1 mutants, in which each of the seven His residues in H43R SOD1 is replaced with Ala.	Histidine	0-3	superoxide dismutase 1	Homo sapiens	210-214
25976113-3	2016	In the present study, we used affinity purification to identify PsGPA1-interacting proteins, including PsHint1, a histidine triad (HIT) domain-containing protein orthologous to human HIT nucleotide-binding protein 1 (HINT1).	Histidine	114-123	histidine triad nucleotide binding protein 1	Homo sapiens	183-215
26730681-1	2016	In this work, nitrogen-doped carbon nanoparticle (N-CNP) modulated turn-on fluorescent probes were developed for rapid and selective detection of histidine.	Histidine	146-155	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	52-55
26688387-3	2016	DNA sequence analysis of the androgen receptor gene of androgen insensitivity syndromes revealed three missense mutations - c.C1713&gt;G resulting in the replacement of a highly conserved histidine residue with glutamine p.	Histidine	188-197	androgen receptor	Homo sapiens	29-46
26730681-4	2016	Under the optimal conditions, a linear relationship between the increased fluorescence intensity of N-CNP/Cu(II) ion conjugates and the concentration of histidine was established in the range from 0.5 to 60 muM.	Histidine	153-162	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	102-105
26730681-6	2016	In addition, the as-prepared N-CNP/Cu(II) ion nanoprobes showed excellent biocompatibility and were applied for a histidine imaging assay in living cells, which presented great potential in the bio-labeling assay and clinical diagnostic applications.	Histidine	114-123	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	31-34
26627822-1	2016	Crystallographic evidence suggests that the pH-dependent affinity of IgG molecules for the neonatal Fc receptor (FcRn) receptor primarily arises from salt bridges involving IgG histidine residues, resulting in moderate affinity at mildly acidic conditions.	Histidine	177-186	Fc gamma receptor and transporter	Homo sapiens	91-111
26627822-1	2016	Crystallographic evidence suggests that the pH-dependent affinity of IgG molecules for the neonatal Fc receptor (FcRn) receptor primarily arises from salt bridges involving IgG histidine residues, resulting in moderate affinity at mildly acidic conditions.	Histidine	177-186	Fc gamma receptor and transporter	Homo sapiens	113-117
27648004-4	2016	This complex can maintain 50% of its original oxygenation capacity after 30 cycles in 24 h and retain 5% of the original oxygenation capacity after more than 260 cycles after 72 h. When a ligand analogue was linked to histidine (His), the new complex exhibited as excellent reversible oxygenation property as His-Co(II) complex.	Histidine	218-227	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	313-319
26636774-6	2016	This approach was used to synthesize both the wild-type PHPT1 and an analogue in which the active-site histidine was substituted with the unnatural and isosteric amino acid beta-thienyl-l-alanine.	Histidine	103-112	phosphohistidine phosphatase 1	Homo sapiens	56-61
27648004-4	2016	This complex can maintain 50% of its original oxygenation capacity after 30 cycles in 24 h and retain 5% of the original oxygenation capacity after more than 260 cycles after 72 h. When a ligand analogue was linked to histidine (His), the new complex exhibited as excellent reversible oxygenation property as His-Co(II) complex.	Histidine	229-232	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	313-319
27648004-4	2016	This complex can maintain 50% of its original oxygenation capacity after 30 cycles in 24 h and retain 5% of the original oxygenation capacity after more than 260 cycles after 72 h. When a ligand analogue was linked to histidine (His), the new complex exhibited as excellent reversible oxygenation property as His-Co(II) complex.	Histidine	309-312	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	313-319
26405758-5	2016	In this study, a human LTF fragment (amino acid residues 343-682) covering the C-lobe was expressed with a histidine tag in E. coli and the purified polypeptide refolded through a series of buffer changing procedure.	Histidine	107-116	lactotransferrin	Homo sapiens	23-26
26693887-4	2016	The ScFv construct (Vkappa-Linker-VH) was expressed as a fusion protein with N-terminal His tag in Escherichia coli and purified using immobilized metal affinity chromatography (IMAC) without the addition of reducing agents.	Histidine	88-91	immunglobulin heavy chain variable region	Homo sapiens	4-8
26445100-0	2016	Ischaemic concentrations of lactate increase TREK1 channel activity by interacting with a single histidine residue in the carboxy terminal domain.	Histidine	97-106	potassium two pore domain channel subfamily K member 2	Homo sapiens	45-50
26445100-5	2016	Lactate interacts with histidine 328 (H328) in the carboxy terminal domain of hTREK1 channel to decrease its dwell time in the longer closed state.	Histidine	23-32	potassium two pore domain channel subfamily K member 2	Homo sapiens	78-84
26865843-5	2015	A histidine residue at HLA-DRbeta1 position 13 was marginally associated with increased risk of fulminant T1DM (OR, 2.45; 95% CI ,1.01 to 5.94; p = 0.054).	Histidine	2-11	major histocompatibility complex, class II, DR beta 1	Homo sapiens	23-26
26445100-14	2016	Deletion and point mutation experiments suggest that lactate decreases the longer close dwell time incrementally with increase in lactate concentration by interacting with the histidine residue at position 328 (H328) in the carboxy terminal domain of the TREK1 channel.	Histidine	176-185	potassium two pore domain channel subfamily K member 2	Homo sapiens	255-260
27613033-5	2016	It involves bacterially expressed E1, His-tagged Ube2D3 (also called UbcH5c, the best E2 for Nedd4), untagged Nedd4, and untagged ubiquitin (Ub).	Histidine	38-41	ubiquitin conjugating enzyme E2 D3	Homo sapiens	49-55
26494861-6	2016	Homologous knockin of S1P3-mCherry is fully functional pharmacologically and is strongly expressed by immunohistochemistry confocal microscopy in Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4)-positive atrioventricular node and His-Purkinje fibers, with relative less expression in the HCN4-positive sinoatrial node.	Histidine	260-263	sphingosine-1-phosphate receptor 3	Mus musculus	22-26
26646387-4	2016	Subsequently, Tat-NGB-His and His-NGB-His proteins were expressed by inducer methanol and identified by SDS-PAGE, and purified with HisTrap  FF crude column.	Histidine	22-25	neuroglobin	Rattus norvegicus	18-21
26646387-7	2016	After purification, the high purified protein was prepared and exhibited a significant transmembrane transduction of Tat-NGB-His (**p &lt; 0.01, compare to control and His-NGB-His).	Histidine	125-128	neuroglobin	Rattus norvegicus	121-124
26646387-8	2016	Significantly, Tat-NGB-His could protect hypoxia induced injury of PC12 cells and had an obviously difference when comparing to control and His-NGB-His groups (*p &lt; 0.05, **p &lt; 0.01).	Histidine	23-26	neuroglobin	Rattus norvegicus	19-22
26646387-8	2016	Significantly, Tat-NGB-His could protect hypoxia induced injury of PC12 cells and had an obviously difference when comparing to control and His-NGB-His groups (*p &lt; 0.05, **p &lt; 0.01).	Histidine	23-26	neuroglobin	Rattus norvegicus	144-147
26646387-8	2016	Significantly, Tat-NGB-His could protect hypoxia induced injury of PC12 cells and had an obviously difference when comparing to control and His-NGB-His groups (*p &lt; 0.05, **p &lt; 0.01).	Histidine	140-143	neuroglobin	Rattus norvegicus	19-22
26646387-8	2016	Significantly, Tat-NGB-His could protect hypoxia induced injury of PC12 cells and had an obviously difference when comparing to control and His-NGB-His groups (*p &lt; 0.05, **p &lt; 0.01).	Histidine	140-143	neuroglobin	Rattus norvegicus	144-147
26646387-8	2016	Significantly, Tat-NGB-His could protect hypoxia induced injury of PC12 cells and had an obviously difference when comparing to control and His-NGB-His groups (*p &lt; 0.05, **p &lt; 0.01).	Histidine	140-143	neuroglobin	Rattus norvegicus	19-22
26646387-8	2016	Significantly, Tat-NGB-His could protect hypoxia induced injury of PC12 cells and had an obviously difference when comparing to control and His-NGB-His groups (*p &lt; 0.05, **p &lt; 0.01).	Histidine	140-143	neuroglobin	Rattus norvegicus	144-147
26646387-9	2016	The present study first reported the yeast expressed production of Tat-NGB-His and His-NGB-His, and then elucidated the transduction and neuroprotection of Tat-NGB-His on PC12 cell.	Histidine	75-78	neuroglobin	Rattus norvegicus	71-74
26695298-2	2016	HPPD was produced by cloning the hppd gene from Arabidopsis thaliana in E. coli, followed by overexpression and purification by nickel-histidine affinity.	Histidine	135-144	4-hydroxyphenylpyruvate dioxygenase	Arabidopsis thaliana	0-4
26782537-2	2015	To produce an anti-pBD2 antibody, which is not commercially available, we expressed and purified a soluble, his-tagged version of pBD2 (his-pBD2).	Histidine	108-111	defensin beta 1	Sus scrofa	19-23
26782537-2	2015	To produce an anti-pBD2 antibody, which is not commercially available, we expressed and purified a soluble, his-tagged version of pBD2 (his-pBD2).	Histidine	108-111	defensin beta 1	Sus scrofa	130-134
26782537-2	2015	To produce an anti-pBD2 antibody, which is not commercially available, we expressed and purified a soluble, his-tagged version of pBD2 (his-pBD2).	Histidine	108-111	defensin beta 1	Sus scrofa	130-134
27493863-3	2015	Previous mutation analysis revealed the importance of two histidines in the active center, H354 and H358 for Xenopus (6-4) PHR, whose mutations significantly lowered the enzymatic activity.	Histidine	58-68	CPD photolyase-like L homeolog	Xenopus laevis	123-126
26302489-16	2015	A motif of histidine, proline, and aspartic acid in the J domain of DNAJB6a was required for its tumor-suppressive effects and signaling via AKT1.	Histidine	11-20	AKT serine/threonine kinase 1	Homo sapiens	141-145
26493286-5	2015	The latter effect indicates that protonation of histidine residues seems to be important for the fibrillization of monomeric insulin, whereas the pH effect at high concentration may result from off-pathway oligomerization propensity.	Histidine	48-57	insulin	Homo sapiens	125-132
26410104-5	2015	Lastly, PfCS protein-immunized HIS-CD4/B mice were protected from in vivo challenge with transgenic P. berghei sporozoites expressing the PfCS protein.	Histidine	31-34	CD4 molecule	Homo sapiens	35-38
26211916-8	2015	Thus, it appears that TyrB10 limits the conformational freedom of distal His in Lba, tuning down ligand dissociation rate constant by reducing the strength of hydrogen bonding to bound ligand, which the freedom of distal His of Mb allows.	Histidine	73-76	leghemoglobin A	Glycine max	80-83
26190797-3	2015	It is fabricated by the metallo-supramolecular-coordinated interaction between tetraphenylporphyrin zinc (Zn-Por) and histidine.	Histidine	118-127	cytochrome p450 oxidoreductase	Homo sapiens	109-112
26190797-12	2015	Herein, a novel metallo-supramolecular nanogel (SNG) is fabricated by the metallo-supramolecular-coordinated interaction between tetraphenylporphyrin zinc (Zn-Por) and histidine.	Histidine	168-177	cytochrome p450 oxidoreductase	Homo sapiens	159-162
26482532-9	2015	By using in vitro approaches, cell-based and computational techniques, we propose a model whereby PrP(C) coordinating copper with one His in the non-octarepeat region converts to prions at acidic condition.	Histidine	134-137	prion protein	Homo sapiens	98-104
26118700-10	2015	Sodium dodecyl sulfate polyacrylamide gel electrophoresis analysis and immunoblotting with anti-His antibody confirmed the identity of purified Abeta fusion protein and Abeta peptide.	Histidine	96-99	amyloid beta precursor protein	Homo sapiens	144-149
26211916-8	2015	Thus, it appears that TyrB10 limits the conformational freedom of distal His in Lba, tuning down ligand dissociation rate constant by reducing the strength of hydrogen bonding to bound ligand, which the freedom of distal His of Mb allows.	Histidine	221-224	leghemoglobin A	Glycine max	80-83
26086244-6	2015	Here we have carried out detailed analyses of one such gene, amidohydrolase domain containing 1 (AMDHD1) gene, which encodes an enzyme in the histidine catabolic pathway.	Histidine	142-151	amidohydrolase domain containing 1 L homeolog	Xenopus laevis	61-95
26252621-7	2015	The histidine residue binds heme, while the arginine and the tyrosine act as key second sphere residues of the heme-Abeta active site that play a crucial role in its reactivity.	Histidine	4-13	amyloid beta precursor protein	Homo sapiens	116-121
26086244-6	2015	Here we have carried out detailed analyses of one such gene, amidohydrolase domain containing 1 (AMDHD1) gene, which encodes an enzyme in the histidine catabolic pathway.	Histidine	142-151	amidohydrolase domain containing 1 L homeolog	Xenopus laevis	97-103
26345853-7	2015	According to gene ontology analysis, these genes are involved in lung development, respiratory system development, cell cycle, histidine metabolism, the Wnt signaling pathway, and the p53 signaling pathway.	Histidine	127-136	tumor protein p53	Homo sapiens	184-187
26107283-2	2015	The human prion protein (hPrP) fragment encompassing the 91-127 region, also known as the amyloidogenic domain, comprises two copper-binding sites corresponding to His-96 and His-111 residues that act as anchors for Cu(2+) binding.	Histidine	164-167	prion protein	Homo sapiens	25-29
26107283-2	2015	The human prion protein (hPrP) fragment encompassing the 91-127 region, also known as the amyloidogenic domain, comprises two copper-binding sites corresponding to His-96 and His-111 residues that act as anchors for Cu(2+) binding.	Histidine	175-178	prion protein	Homo sapiens	25-29
25556167-0	2015	Pathophysiologic Changes in Extracellular pH Modulate Parathyroid Calcium-Sensing Receptor Activity and Secretion via a Histidine-Independent Mechanism.	Histidine	120-129	calcium sensing receptor	Homo sapiens	66-90
25969353-5	2015	The new Abeta construct expressed insoluble Abeta fused with an N-terminal histidine-tag connected by a linker harboring TEV protease cut site.	Histidine	75-84	amyloid beta precursor protein	Homo sapiens	8-13
26160175-6	2015	TG2 residues Arg-116 and His-134 were identified to be critical for binding of 679-14-E06 as well as other epitope 1 antibodies.	Histidine	25-28	transglutaminase 2	Homo sapiens	0-3
25781680-3	2015	This is exemplified with recombinant his-tagged rhodopsin, which is rapidly extracted from its host membrane and directly assembled into membrane scaffold protein (MSP) nanodiscs.	Histidine	1-4	rhodopsin	Homo sapiens	48-57
25934085-5	2015	Only the sequences of FgfrL1 from a few rodents diverge at the C-terminal region from the canonical sequence, as they appear to have suffered a frameshift mutation within the histidine-rich motif.	Histidine	175-184	fibroblast growth factor receptor like 1	Homo sapiens	22-28
26301925-3	2015	After sequence analysis, the scFv/1N8 gene was cloned into the prokaryotic expression vector PET32a with a His-tag.	Histidine	107-110	immunglobulin heavy chain variable region	Homo sapiens	29-33
26063599-1	2015	HLA-A alleles are characterized by tandem arginine and histidine/arginine motifs (i.e., R65 and H151R motifs) present on the alpha1- and alpha2-helix, respectively.	Histidine	55-64	major histocompatibility complex, class I, A	Homo sapiens	0-5
26301925-5	2015	Moreover, the binding activity and specificity of the scFv were determined by indirect ELISA (His-tag) and competitive ELISA.	Histidine	94-97	immunglobulin heavy chain variable region	Homo sapiens	54-58
25870943-11	2015	In conclusion, the speculated regulatory role of ORF1 X-domain in HEV replication cycle critically depends on the "Asn, Asn, His, Gly, Gly, Gly" segment/secondary structure.	Histidine	125-128	polyprotein	Orthohepevirus A	49-53
26069151-5	2015	Here, we generated Physcomitrella patens lines expressing histidine-tagged PSBS that were exploited to purify the native protein by affinity chromatography.	Histidine	58-67	PSBS	Physcomitrella patens	75-79
26052625-3	2015	One bolaamphiphilic self-assembly with a histidine moiety catalytically hydrolyzed the p-NPA substrate, and the other self-assembly of tyrosyl bolaamphiphile monitored the product of p-NP by photoluminescence quenching.	Histidine	41-50	purine nucleoside phosphorylase	Homo sapiens	87-91
26161660-1	2015	Herpesviruses encode a characteristic serine protease with a unique fold and an active site that comprises the unusual triad Ser-His-His.	Histidine	129-132	coagulation factor II, thrombin	Homo sapiens	38-53
26070068-7	2015	In the GPR4 mutant, in which certain histidine residues were mutated to phenylalanine, proton sensitivity was significantly shifted to the right, and psychosine failed to further inhibit acidic pH-induced SRE activation.	Histidine	37-46	G protein-coupled receptor 4	Homo sapiens	7-11
25940907-1	2015	HLA-A*02:548 differs from A*02:01:01:01 by one nucleotide at position 367T &gt; C resulting in histidine at codon 99.	Histidine	95-104	major histocompatibility complex, class I, A	Homo sapiens	0-5
26056269-5	2015	Consequently, upon complex formation, a conserved His residue of HypA comes close to the N-terminal conserved motif of HypA and forms a Ni-binding site, to which a Ni ion is bound with a nearly square-planar geometry.	Histidine	50-53	pre-mRNA processing factor 40 homolog A	Homo sapiens	65-69
26056269-5	2015	Consequently, upon complex formation, a conserved His residue of HypA comes close to the N-terminal conserved motif of HypA and forms a Ni-binding site, to which a Ni ion is bound with a nearly square-planar geometry.	Histidine	50-53	pre-mRNA processing factor 40 homolog A	Homo sapiens	119-123
26182435-5	2015	To characterize this mobility discrepancy and the effects of post-translational modifications (PTMs), we expressed various deleted His-Bcnt in E. coli and HEK cells and found that an acidic stretch in the N-terminal region is a main cause of the gel shift.	Histidine	131-134	craniofacial development protein 1	Homo sapiens	135-139
25979711-7	2015	The *04:01 SNP (rs660895, p = 0.0003), *04:01 allele (p = 0.0002), and HLA-DRbeta1 amino acids histidine at position 13 (p = 0.0005) and valine at position 11 (p = 0.0012) significantly associated with radiological progression.	Histidine	95-104	major histocompatibility complex, class II, DR beta 1	Homo sapiens	71-74
26070068-9	2015	We conclude that some imidazopyridine compounds show specificity to GPR4 as negative allosteric modulators with a different action mode from psychosine, an antagonist susceptible to histidine residues, and are useful for characterizing GPR4-mediated acidic pH-induced biological actions.	Histidine	182-191	G protein-coupled receptor 4	Homo sapiens	68-72
26055918-1	2015	The aim of this study is to investigate the effects of leucine (Leu) and histidine (His) on the expression of both the mammalian target of rapamycin (mTOR) signaling pathway-related proteins and caseins in immortalized bovine mammary epithelial cells (CMEC-H), using a single supplement through Western blotting.	Histidine	73-82	mechanistic target of rapamycin kinase	Homo sapiens	119-148
26061460-6	2015	Further analyses identified histidine 862 as a critical residue for USP15"s catalytic activity.	Histidine	28-37	ubiquitin specific peptidase 15	Homo sapiens	68-73
25728983-2	2015	The surface plasmon resonance technique was employed for a fast binding screening of l-histidine and its derivatives, 1-benzyl-L-histidine and 1-methyl-L-histidine, as potential ligands for the biorecognition of three plasmids with different sizes (6.05, 8.70, and 14 kbp).	Histidine	85-96	kinesin family binding protein	Homo sapiens	268-271
26057801-5	2015	THB1 resembles other TrHb1s, but also exhibits distinct features associated with the coordination of the heme iron by a histidine (proximal) and a lysine (distal).	Histidine	120-129	uncharacterized protein	Chlamydomonas reinhardtii	0-4
26055918-1	2015	The aim of this study is to investigate the effects of leucine (Leu) and histidine (His) on the expression of both the mammalian target of rapamycin (mTOR) signaling pathway-related proteins and caseins in immortalized bovine mammary epithelial cells (CMEC-H), using a single supplement through Western blotting.	Histidine	73-82	mechanistic target of rapamycin kinase	Homo sapiens	150-154
26055918-1	2015	The aim of this study is to investigate the effects of leucine (Leu) and histidine (His) on the expression of both the mammalian target of rapamycin (mTOR) signaling pathway-related proteins and caseins in immortalized bovine mammary epithelial cells (CMEC-H), using a single supplement through Western blotting.	Histidine	84-87	mechanistic target of rapamycin kinase	Homo sapiens	119-148
26055918-1	2015	The aim of this study is to investigate the effects of leucine (Leu) and histidine (His) on the expression of both the mammalian target of rapamycin (mTOR) signaling pathway-related proteins and caseins in immortalized bovine mammary epithelial cells (CMEC-H), using a single supplement through Western blotting.	Histidine	84-87	mechanistic target of rapamycin kinase	Homo sapiens	150-154
25497832-2	2015	The protein sequence of yellow catfish SCD1 and Fads2 (Delta6) possessed all the characteristics of microsomal fatty acid Fads2 (Delta6), including three histidine boxes, two transmembrane regions and one N-terminal cytochrome b5 domain containing heme-binding motif.	Histidine	154-163	fatty acid desaturase 2	Homo sapiens	48-53
25534683-2	2015	METHODS: Arginine, cysteine, and histidine modified trimethyl chitosan were synthesized and employed to self-assemble with plasmid DNA (pDNA) to form nanocomplexes, namely TRNC, TCNC, and THNC, respectively.	Histidine	33-42	mitochondrially encoded tRNA cysteine	Homo sapiens	172-176
25497832-3	2015	The protein sequence of yellow catfish ELOVL5 possessed characteristic features of ELOVL5, including multiple transmembrane regions, endoplasmic reticulum retention signal and a single histidine box.	Histidine	185-194	ELOVL fatty acid elongase 5	Homo sapiens	39-45
25839944-7	2015	Collectively, our results indicate that a reduction in the basicity of the lower axial ligand causes changes to the cofactor"s electronic structure in the Co(II) state that replicate the effects seen upon binding of Co(II)Cbl to Class I isomerases, which replace the lower axial dimethylbenzimidazole ligand of AdoCbl with a protein-derived histidine (His) residue.	Histidine	341-350	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-161
25832546-6	2015	Additional experiments of human growth hormone melting in the presence of histidine, lysine, and sodium chloride were performed.	Histidine	74-83	growth hormone 1	Homo sapiens	32-46
25690668-8	2015	RESULTS: Our findings demonstrate that substitutions of R1205 with histidine, cysteine or serine all result in markedly reduced survival of full-length recombinant VWF.	Histidine	67-76	von Willebrand factor	Homo sapiens	164-167
25860111-6	2015	In conclusion, curcumin and PCI-34058-mediated ligand-dependent HDAC1 tunnel closure interferes negatively with the ASP-HIS charge relay system in HDAC1.	Histidine	120-123	histone deacetylase 1	Homo sapiens	64-69
25860111-6	2015	In conclusion, curcumin and PCI-34058-mediated ligand-dependent HDAC1 tunnel closure interferes negatively with the ASP-HIS charge relay system in HDAC1.	Histidine	120-123	histone deacetylase 1	Homo sapiens	147-152
25839944-7	2015	Collectively, our results indicate that a reduction in the basicity of the lower axial ligand causes changes to the cofactor"s electronic structure in the Co(II) state that replicate the effects seen upon binding of Co(II)Cbl to Class I isomerases, which replace the lower axial dimethylbenzimidazole ligand of AdoCbl with a protein-derived histidine (His) residue.	Histidine	352-355	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-161
26069730-0	2015	Effect of the distal histidine on the peroxidatic activity of monomeric cytoglobin.	Histidine	21-30	cytoglobin	Homo sapiens	72-82
26069730-5	2015	In contrast distal histidine mutants of cytoglobin (H81Y and H81V) show very low peroxidase activity but enhanced radical-induced degradation.	Histidine	19-28	cytoglobin	Homo sapiens	40-50
25751413-1	2015	Mutational analysis of Sulfolobus solfataricus class II alpha-mannosidase was focused on side chains that interact with the hydroxyls of the -1 mannosyl of the substrate (Asp-534) or form ligands to the active site divalent metal ion (His-228 and His-533) judged from crystal structures of homologous enzymes.	Histidine	235-238	SDR family oxidoreductase	Saccharolobus solfataricus	56-73
25451601-0	2015	Transport of L-glutamine, L-alanine, L-arginine and L-histidine by the neuron-specific Slc38a8 (SNAT8) in CNS.	Histidine	52-63	solute carrier family 38, member 8	Mus musculus	87-94
25451601-4	2015	We show that SLC38A8 has preference for transporting L-glutamine, L-alanine, L-arginine, L-histidine and L-aspartate using a Na+-dependent transport mechanism and that the functional characteristics of SNAT8 have highest similarity to the known System A transporters.	Histidine	89-100	solute carrier family 38, member 8	Mus musculus	13-20
25761537-4	2015	Under the optimal conditions, histidine and cysteine can be detected in the concentration ranges of 0.25-9 and 0.25-7 muM; besides, the detection limits are found to be 87 and 111 nM (S/N = 3), respectively.	Histidine	30-39	latexin	Homo sapiens	118-121
25754556-8	2015	Bioinformatic results indicate that peptide "Ser-His-Ser-Leu-Leu-Ser-Ser" binds to p16 molecule with the best binding score and does not interfere with the common protein functions of p16.	Histidine	49-52	cyclin dependent kinase inhibitor 2A	Homo sapiens	83-86
25754556-9	2015	Peptide blocking experiment shows that the phage-displayed peptide "Ser-His-Ser-Leu-Leu-Ser-Ser" can conceal p16 from monoclonal antibody interaction.	Histidine	72-75	cyclin dependent kinase inhibitor 2A	Homo sapiens	109-112
25751413-1	2015	Mutational analysis of Sulfolobus solfataricus class II alpha-mannosidase was focused on side chains that interact with the hydroxyls of the -1 mannosyl of the substrate (Asp-534) or form ligands to the active site divalent metal ion (His-228 and His-533) judged from crystal structures of homologous enzymes.	Histidine	247-250	SDR family oxidoreductase	Saccharolobus solfataricus	56-73
25211009-2	2015	Recent studies show that heme binds to the His residue of Abeta with the iron center and subsequently forms an Abeta-heme complex, which can inhibit Abeta aggregation.	Histidine	43-46	amyloid beta precursor protein	Homo sapiens	58-63
25211009-2	2015	Recent studies show that heme binds to the His residue of Abeta with the iron center and subsequently forms an Abeta-heme complex, which can inhibit Abeta aggregation.	Histidine	43-46	amyloid beta precursor protein	Homo sapiens	111-116
25721131-0	2015	Histidine-rich stabilized polyplexes for cMet-directed tumor-targeted gene transfer.	Histidine	0-9	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	41-45
25609249-8	2015	Access to a conserved catalytic triad consisting of Cys(101), His(264), and Asp(275) is regulated by the flexible BL2.	Histidine	62-65	cell adhesion molecule 1	Homo sapiens	114-117
25613910-4	2015	A 6 x histidine tag was fused to the C-terminus of IC16-scFv allowing hybridization with a small organic beta-sheet binder via Ni-NTA complexation.	Histidine	6-15	immunglobulin heavy chain variable region	Homo sapiens	56-60
25671465-3	2015	Reduction of the Co(III)-sb by PET initiates displacement of the inert axial imidazole ligands, promoting coordination to active site histidines of alpha-thrombin.	Histidine	134-144	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	17-23
25671465-3	2015	Reduction of the Co(III)-sb by PET initiates displacement of the inert axial imidazole ligands, promoting coordination to active site histidines of alpha-thrombin.	Histidine	134-144	coagulation factor II, thrombin	Homo sapiens	154-162
25609251-2	2015	Tdp1 contains two conserved catalytic histidines: a nucleophilic His (His(nuc)) that attacks DNA adducts to form a covalent 3"-phosphohistidyl intermediate and a general acid/base His (His(gab)), which resolves the Tdp1-DNA linkage.	Histidine	38-48	tyrosyl-DNA phosphodiesterase 1	Saccharomyces cerevisiae S288C	0-4
25549551-5	2015	Docking study showed that the methoxy moeities of 6a inserted deep inside the 2 -pocket of the COX-2 active site, where the O-atoms of such groups underwent an H-bonding interaction with His(90) (3.02 A), Arg(513) (1.94, 2.83 A), and Gln(192) (3.25 A).	Histidine	187-190	prostaglandin-endoperoxide synthase 2	Homo sapiens	95-100
25660271-1	2015	We report the design and synthesis of an aquacarbonyl Ru(II) dication cis-[Ru(CO)2(H2O)4](2+) reagent for histidine (His)-selective metallation of interleukin (IL)-8 at site 33.	Histidine	106-115	C-X-C motif chemokine ligand 8	Homo sapiens	147-165
25660271-1	2015	We report the design and synthesis of an aquacarbonyl Ru(II) dication cis-[Ru(CO)2(H2O)4](2+) reagent for histidine (His)-selective metallation of interleukin (IL)-8 at site 33.	Histidine	117-120	C-X-C motif chemokine ligand 8	Homo sapiens	147-165
25609251-2	2015	Tdp1 contains two conserved catalytic histidines: a nucleophilic His (His(nuc)) that attacks DNA adducts to form a covalent 3"-phosphohistidyl intermediate and a general acid/base His (His(gab)), which resolves the Tdp1-DNA linkage.	Histidine	65-68	tyrosyl-DNA phosphodiesterase 1	Saccharomyces cerevisiae S288C	0-4
25609251-2	2015	Tdp1 contains two conserved catalytic histidines: a nucleophilic His (His(nuc)) that attacks DNA adducts to form a covalent 3"-phosphohistidyl intermediate and a general acid/base His (His(gab)), which resolves the Tdp1-DNA linkage.	Histidine	65-68	tyrosyl-DNA phosphodiesterase 1	Saccharomyces cerevisiae S288C	215-219
25609251-2	2015	Tdp1 contains two conserved catalytic histidines: a nucleophilic His (His(nuc)) that attacks DNA adducts to form a covalent 3"-phosphohistidyl intermediate and a general acid/base His (His(gab)), which resolves the Tdp1-DNA linkage.	Histidine	70-73	tyrosyl-DNA phosphodiesterase 1	Saccharomyces cerevisiae S288C	0-4
25609251-2	2015	Tdp1 contains two conserved catalytic histidines: a nucleophilic His (His(nuc)) that attacks DNA adducts to form a covalent 3"-phosphohistidyl intermediate and a general acid/base His (His(gab)), which resolves the Tdp1-DNA linkage.	Histidine	70-73	tyrosyl-DNA phosphodiesterase 1	Saccharomyces cerevisiae S288C	215-219
25609251-2	2015	Tdp1 contains two conserved catalytic histidines: a nucleophilic His (His(nuc)) that attacks DNA adducts to form a covalent 3"-phosphohistidyl intermediate and a general acid/base His (His(gab)), which resolves the Tdp1-DNA linkage.	Histidine	70-73	tyrosyl-DNA phosphodiesterase 1	Saccharomyces cerevisiae S288C	0-4
25609251-2	2015	Tdp1 contains two conserved catalytic histidines: a nucleophilic His (His(nuc)) that attacks DNA adducts to form a covalent 3"-phosphohistidyl intermediate and a general acid/base His (His(gab)), which resolves the Tdp1-DNA linkage.	Histidine	70-73	tyrosyl-DNA phosphodiesterase 1	Saccharomyces cerevisiae S288C	215-219
25609251-2	2015	Tdp1 contains two conserved catalytic histidines: a nucleophilic His (His(nuc)) that attacks DNA adducts to form a covalent 3"-phosphohistidyl intermediate and a general acid/base His (His(gab)), which resolves the Tdp1-DNA linkage.	Histidine	70-73	tyrosyl-DNA phosphodiesterase 1	Saccharomyces cerevisiae S288C	0-4
25609251-2	2015	Tdp1 contains two conserved catalytic histidines: a nucleophilic His (His(nuc)) that attacks DNA adducts to form a covalent 3"-phosphohistidyl intermediate and a general acid/base His (His(gab)), which resolves the Tdp1-DNA linkage.	Histidine	70-73	tyrosyl-DNA phosphodiesterase 1	Saccharomyces cerevisiae S288C	215-219
25609251-8	2015	Indeed, genetic, biochemical, and mass spectrometry analyses show that a highly conserved His, immediately N-terminal to His(nuc), can act as a nucleophile to catalyze the formation of a covalent Tdp1-DNA intermediate.	Histidine	90-93	tyrosyl-DNA phosphodiesterase 1	Saccharomyces cerevisiae S288C	196-200
25609251-8	2015	Indeed, genetic, biochemical, and mass spectrometry analyses show that a highly conserved His, immediately N-terminal to His(nuc), can act as a nucleophile to catalyze the formation of a covalent Tdp1-DNA intermediate.	Histidine	121-124	tyrosyl-DNA phosphodiesterase 1	Saccharomyces cerevisiae S288C	196-200
25658043-0	2015	Resolution of key roles for the distal pocket histidine in cytochrome C nitrite reductases.	Histidine	46-55	cytochrome c, somatic	Homo sapiens	59-71
25658043-4	2015	Here we describe properties of a penta-heme cytochrome c nitrite reductase in which the distal His has been substituted by Asn.	Histidine	95-98	cytochrome c, somatic	Homo sapiens	44-56
25576873-5	2015	The mutation of the histidine residue at the 78th but not the 84th position from the N-terminal of zGPR4 to phenylalanine attenuated the proton-induced SRE-promoter activities.	Histidine	20-29	G protein-coupled receptor 4	Danio rerio	99-104
25336041-6	2015	These findings identified a novel causal mutation in ALS in close proximity with one of the three histidine residues (H120) of SOD1 interacting with copper.	Histidine	98-107	superoxide dismutase 1, soluble	Mus musculus	127-131
25480797-6	2015	Plasma AA concentration was decreased in Slc43a2 null pups, in particular that of non-essential AAs alanine, serine, histidine and proline.	Histidine	117-126	solute carrier family 43, member 2	Mus musculus	41-48
25561730-5	2015	The molecular modeling study showed that Ile(196) at transmembrane helix 2, Met(233) at ECL1, and Asn(302) at ECL2 of GLP1R have contacts with His(1) and Thr(7) of GLP-1.	Histidine	143-146	glucagon	Homo sapiens	164-169
25574816-1	2015	BACKGROUND: Phosphohistidine phosphatase 1 (PHPT1), also named protein histidine phosphatase (PHP), is a eukaryotic enzyme dephosphorylating proteins and peptides that are phosphorylated on a histidine residue.	Histidine	19-28	phosphohistidine phosphatase 1	Homo sapiens	29-42
25574816-1	2015	BACKGROUND: Phosphohistidine phosphatase 1 (PHPT1), also named protein histidine phosphatase (PHP), is a eukaryotic enzyme dephosphorylating proteins and peptides that are phosphorylated on a histidine residue.	Histidine	19-28	phosphohistidine phosphatase 1	Homo sapiens	44-49
25574816-7	2015	RESULTS: Histone H1.2, which lacks histidine, was phosphorylated by phosphoramidate on several lysine residues, as shown by MS. PHPT1 was shown to dephosphorylate phosphohistone H1 at a rate similar to that previously described for the dephosphorylation of phosphohistidine-containing peptides.	Histidine	35-44	phosphohistidine phosphatase 1	Homo sapiens	128-133
25656388-9	2015	Fluorescence size exclusion chromatography of hERG-GFP-His 8 solubilized in Fos-Choline-12 supplemented with cholesteryl-hemisuccinate and Astemizole resulted in a monodisperse elution profile demonstrating a high quality of the hERG channels.	Histidine	55-58	ETS transcription factor ERG	Homo sapiens	46-50
25561737-8	2015	In CAII, binding to MCT1 and MCT4 is mediated by a histidine residue at position 64.	Histidine	51-60	malignant T-cell amplified sequence 1 S homeolog	Xenopus laevis	20-24
25597800-1	2015	In this paper, a kind of gold nanoparticle (GNP)-based colorimetric assay has been developed for studying the reversible interaction of beta-amyloid peptide (Abeta) with Cu(2+) and Zn(2+), and quantitatively analyzing four inhibitors (i.e., EDTA, EGTA, histidine and clioquinol) of Cu(2+)/Zn(2+) induced Abeta assembly.	Histidine	253-262	amyloid beta precursor protein	Homo sapiens	136-156
25656388-9	2015	Fluorescence size exclusion chromatography of hERG-GFP-His 8 solubilized in Fos-Choline-12 supplemented with cholesteryl-hemisuccinate and Astemizole resulted in a monodisperse elution profile demonstrating a high quality of the hERG channels.	Histidine	55-58	ETS transcription factor ERG	Homo sapiens	229-233
25643626-7	2015	Serine, proline, or histidine-mediated lifespan extension was greatly inhibited in eat-2 worms, a model of dietary restriction, in daf-16/FOXO, sir-2.1, rsks-1 (ribosomal S6 kinase), gcn-2, and aak-2 (AMPK) longevity pathway mutants, and in bec-1 autophagy-defective knockdown worms.	Histidine	20-29	Deacetylase sirtuin-type domain-containing protein;NAD-dependent protein deacetylase sir-2.1	Caenorhabditis elegans	144-151
25643626-7	2015	Serine, proline, or histidine-mediated lifespan extension was greatly inhibited in eat-2 worms, a model of dietary restriction, in daf-16/FOXO, sir-2.1, rsks-1 (ribosomal S6 kinase), gcn-2, and aak-2 (AMPK) longevity pathway mutants, and in bec-1 autophagy-defective knockdown worms.	Histidine	20-29	Eukaryotic translation initiation factor 2-alpha kinase gcn-2	Caenorhabditis elegans	183-188
25537304-3	2015	To isolate the protein factors ruling the redox chemistry, we used as a system model, the undecapeptide microperoxidase (MP11), a heme peptide derived from cytochrome c proteolysis that retains the proximal histidine bound to the Fe(III) atom.	Histidine	207-216	non-compact myelin associated protein	Homo sapiens	121-125
24961462-5	2015	In all three proteins, the phosphorylation of a specific histidine residue is of regulatory importance for protein function, and these phosphohistidines are cleaved by a counteracting 14 kDa phosphohistidine phosphatase (PHP).	Histidine	57-66	phosphohistidine phosphatase 1	Homo sapiens	184-219
25231380-4	2015	Multivariate statistics highlighted consistent metabolic changes in gastrocnemius muscle following Akt1 activation, which included significant reductions of serine and histidine-containing dipeptides (anserine and carnosine), in addition to increased concentrations of phosphorylated sugars.	Histidine	168-177	thymoma viral proto-oncogene 1	Mus musculus	99-103
25654118-4	2015	Successful purification of GCR and GC was achieved using the 6X His-tag method.	Histidine	64-67	nuclear receptor subfamily 3 group C member 1	Homo sapiens	27-30
25281857-6	2015	Treatment of pre-adipocytes with histidine, an ALP inhibitor, blocked lipid accumulation.	Histidine	33-42	alkaline phosphatase, placental	Homo sapiens	47-50
25747199-3	2015	ATP-dependent uptake of isoleucine and histidine by the vacuolar vesicles of an AVT exporter mutant was lost by introducing avt1  mutation.	Histidine	39-48	Avt1p	Saccharomyces cerevisiae S288C	124-128
25747199-6	2015	V-ATPase-dependent acidification of the vesicles was declined by the addition of isoleucine or histidine, depending upon Avt1p.	Histidine	95-104	Avt1p	Saccharomyces cerevisiae S288C	121-126
25172962-3	2015	Here, we used diethylpyrocarbonate (DEPC) modification to obtain a His(B5) mono-ethyloxyformylated insulin (DMI-B(5)).	Histidine	67-70	insulin	Homo sapiens	99-106
26307718-4	2015	By taking advantage of a His-tag present in recombinant Tf and applying Ni affinity purification, the exogenous human serum Tf can be greatly enriched from rat CSF, despite the presence of the abundant endogenous protein.	Histidine	25-28	transferrin	Rattus norvegicus	124-126
25171714-0	2015	The histidine composition of the amyloid-beta domain, but not the E1 copper binding domain, modulates beta-secretase processing of amyloid-beta protein precursor in Alzheimer"s disease.	Histidine	4-13	amyloid beta precursor protein	Homo sapiens	33-45
25171714-0	2015	The histidine composition of the amyloid-beta domain, but not the E1 copper binding domain, modulates beta-secretase processing of amyloid-beta protein precursor in Alzheimer"s disease.	Histidine	4-13	amyloid beta precursor protein	Homo sapiens	131-143
25171714-2	2015	We have investigated the role of histidine residues within the extracellular E1 copper binding and Abeta domains of AbetaPP in its proteolysis.	Histidine	33-42	amyloid beta precursor protein	Homo sapiens	116-123
25171714-4	2015	Mutation of histidine 14 within the Abeta-domain specifically down-regulated beta-secretase processing without impacting on non-amyloidogenic proteolysis.	Histidine	12-21	amyloid beta precursor protein	Homo sapiens	36-41
25171714-5	2015	Understanding how histidine 14 participates in AbetaPP proteolysis may reveal new intervention points for AD treatments.	Histidine	18-27	amyloid beta precursor protein	Homo sapiens	47-54
25617389-2	2015	The usefulness of the morpholinopropanesulfonic acid (MOPS)-histidine buffer in detecting beta2-transferrin, which is only found in the cerebrospinal fluid, was compared with the standard barbital buffer.	Histidine	60-69	transferrin	Homo sapiens	96-107
25617389-4	2015	RESULTS: The MOPS-histidine and barbital buffers revealed 5 transferrin bands and 2 transferrin bands with CSF, respectively.	Histidine	18-27	transferrin	Homo sapiens	60-71
25617389-4	2015	RESULTS: The MOPS-histidine and barbital buffers revealed 5 transferrin bands and 2 transferrin bands with CSF, respectively.	Histidine	18-27	transferrin	Homo sapiens	84-95
25617389-8	2015	CONCLUSION: Agarose electrophoresis with the MOPS-histidine buffer increases the resolution of transferrin isoforms.	Histidine	50-59	transferrin	Homo sapiens	95-106
25697521-0	2015	Analysis of conformational changes in rhodopsin by histidine hydrogen-deuterium exchange.	Histidine	51-60	rhodopsin	Homo sapiens	38-47
25697521-5	2015	Herein we describe an experimental protocol to characterize rhodopsin by His-HDX-MS.	Histidine	73-76	rhodopsin	Homo sapiens	60-69
25343534-4	2014	Mutation of the central V266 to histidine in the dimer interface of caspase-3 inactivates the enzyme by introducing steric clashes that may ultimately affect positioning of a helix on the protein surface.	Histidine	32-41	caspase 3	Homo sapiens	68-77
24884357-6	2015	The soluble scFv anti-p17 from crude HB2151 lysated was subsequently purified by immobilized metal ion affinity chromatography (IMAC) with His-tag.	Histidine	139-142	immunglobulin heavy chain variable region	Homo sapiens	12-16
24884357-6	2015	The soluble scFv anti-p17 from crude HB2151 lysated was subsequently purified by immobilized metal ion affinity chromatography (IMAC) with His-tag.	Histidine	139-142	family with sequence similarity 72 member B	Homo sapiens	22-25
26095376-1	2015	An alpha-MSH peptide analogue, named MTII (Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]- NH2), is one of the most important ligands of melanotropic receptors but are relatively nonselective.	Histidine	56-59	proopiomelanocortin	Homo sapiens	3-12
26217706-0	2015	An endogenous "non-specific" protein detected by a His-tag antibody is human transcription regulator YY1.	Histidine	51-54	YY1 transcription factor	Homo sapiens	101-104
25342750-5	2014	We identified the cysteine- and histidine-rich domain containing 1 (CHORDC1) as a novel host factor target of miR-26b.	Histidine	32-41	cysteine and histidine rich domain containing 1	Homo sapiens	68-75
25685357-8	2014	The other peptide (Valine-Histidine-Proline-Lysine-Glutamine-Histidine-Arginine or VHPKQHR) was identified via phage display and targets vascular endothelial cells through the vascular cell adhesion molecule-1 (VCAM-1).	Histidine	26-35	vascular cell adhesion molecule 1	Homo sapiens	176-209
25685357-8	2014	The other peptide (Valine-Histidine-Proline-Lysine-Glutamine-Histidine-Arginine or VHPKQHR) was identified via phage display and targets vascular endothelial cells through the vascular cell adhesion molecule-1 (VCAM-1).	Histidine	26-35	vascular cell adhesion molecule 1	Homo sapiens	211-217
25172132-9	2014	We show that the thrombin-mediated cleavage of two histidine tags from the purified recombinant protein and the adsorption of these histidine tags and their associated endotoxins to a nickel affinity column result in an appreciable depletion of the endotoxins in the purified protein fraction.	Histidine	132-141	coagulation factor II, thrombin	Homo sapiens	17-25
25230085-1	2014	Within the phospholipase A2 (PLA2) superfamily, secreted PLA2 (sPLA2) enzymes comprise the largest family that contains 11 to 12 mammalian isoforms with a conserved His-Asp catalytic dyad.	Histidine	165-168	phospholipase A2 group IB	Homo sapiens	11-27
25230085-1	2014	Within the phospholipase A2 (PLA2) superfamily, secreted PLA2 (sPLA2) enzymes comprise the largest family that contains 11 to 12 mammalian isoforms with a conserved His-Asp catalytic dyad.	Histidine	165-168	phospholipase A2 group IB	Homo sapiens	29-33
25230085-1	2014	Within the phospholipase A2 (PLA2) superfamily, secreted PLA2 (sPLA2) enzymes comprise the largest family that contains 11 to 12 mammalian isoforms with a conserved His-Asp catalytic dyad.	Histidine	165-168	phospholipase A2 group IB	Homo sapiens	57-61
25172132-9	2014	We show that the thrombin-mediated cleavage of two histidine tags from the purified recombinant protein and the adsorption of these histidine tags and their associated endotoxins to a nickel affinity column result in an appreciable depletion of the endotoxins in the purified protein fraction.	Histidine	51-60	coagulation factor II, thrombin	Homo sapiens	17-25
25427151-6	2014	The results of this study have pointed to a central role of the conserved His-Arg-Asp (HRD) motif in the catalytic loop and the Asp-Phe-Gly (DFG) motif as key mediators of structural stability and allosteric communications in the ErbB kinases.	Histidine	74-77	epidermal growth factor receptor	Homo sapiens	230-234
25310453-8	2014	We apply similar analysis to oleic acid binding and predict that the Ca(2+)-aLA complex can bind to oleic acid through the basic histidine (H) 32 of the A2 helix and the hydrophobic residues, namely, isoleucine (I) 59, W60 and I95, of the interfacial cleft.	Histidine	129-138	lactalbumin alpha	Homo sapiens	76-79
25231310-5	2014	Site-directed mutagenesis data suggest that the mesonivirus 3CL(pro) employs a catalytic Cys-His dyad comprised of CavV pp1a/pp1ab residues Cys-1539 and His-1434.	Histidine	93-96	replicase polyprotein 1a	Cavally virus	120-124
25058381-1	2014	Gaduscidin-1 and -2 (GAD-1 and GAD-2) are antimicrobial peptides (AMPs) that contain several histidine residues and are thus expected to exhibit pH-dependent activity.	Histidine	93-102	glutamate decarboxylase 2	Homo sapiens	31-36
25369456-5	2014	L-histidine completely inhibited growth and its effect on viability was inversely related to Flo11p expression.	Histidine	0-11	Flo11p	Saccharomyces cerevisiae S288C	93-99
24878753-0	2014	Optimization of expression of untagged and histidine-tagged human recombinant thrombin precursors in Escherichia coli.	Histidine	43-52	coagulation factor II, thrombin	Homo sapiens	78-86
25348237-6	2014	Usage of the eukaryotic THI4-type sulfur relay was initially considered less likely for thiamine biosynthesis in archaea, since the active-site cysteine residue of yeast THI4p that donates the sulfur to the thiazole ring by a suicide mechanism is replaced by a histidine residue in many archaeal THI4 homologs and these are described as D-ribose-1,5-bisphosphate isomerases.	Histidine	261-270	thiamine thiazole synthase	Saccharomyces cerevisiae S288C	24-28
25252954-2	2014	The mice inherited abolished IgG serum titers in a recessive manner caused by a spontaneous G   A transition mutation in codon 112 of the aicda gene, leading to an arginine to histidine replacement (AID(R112H)).	Histidine	176-185	activation-induced cytidine deaminase	Mus musculus	199-202
25212215-7	2014	Here, we present the development of efficient protocols that resulted in pure and stable His-tagged VIP1 and VirE2.	Histidine	89-92	VIRE2-interacting protein 1	Arabidopsis thaliana	100-104
25348237-6	2014	Usage of the eukaryotic THI4-type sulfur relay was initially considered less likely for thiamine biosynthesis in archaea, since the active-site cysteine residue of yeast THI4p that donates the sulfur to the thiazole ring by a suicide mechanism is replaced by a histidine residue in many archaeal THI4 homologs and these are described as D-ribose-1,5-bisphosphate isomerases.	Histidine	261-270	thiamine thiazole synthase	Saccharomyces cerevisiae S288C	170-175
25348237-6	2014	Usage of the eukaryotic THI4-type sulfur relay was initially considered less likely for thiamine biosynthesis in archaea, since the active-site cysteine residue of yeast THI4p that donates the sulfur to the thiazole ring by a suicide mechanism is replaced by a histidine residue in many archaeal THI4 homologs and these are described as D-ribose-1,5-bisphosphate isomerases.	Histidine	261-270	thiamine thiazole synthase	Saccharomyces cerevisiae S288C	170-174
25178380-2	2014	The expression of recombinant 6xhis-gVEGF164 protein was induced by 0.5 mM isopropyl thio-beta-D-galactoside at 32 C. Recombinant goat VEGF164 (rgVEGF164) was purified and identi ed by western blot using monoclonal anti-his and anti-VEGF antibodies.	Histidine	32-35	vascular endothelial growth factor A	Capra hircus	37-41
25290245-7	2014	Previously, we reported that the His-rich domain of selenoprotein P (SelP-H) inhibited metal-induced aggregation and toxicity of Abeta, due to its metal chelation ability.	Histidine	33-36	selenoprotein P	Homo sapiens	52-67
25242525-8	2014	Analyses of the pseudo metal-binding motif in CSN6 suggest that the loss of two key histidine residues may contribute to the lack of catalytic activity in CSN6.	Histidine	84-93	COP9 signalosome subunit 6	Homo sapiens	46-50
25242525-8	2014	Analyses of the pseudo metal-binding motif in CSN6 suggest that the loss of two key histidine residues may contribute to the lack of catalytic activity in CSN6.	Histidine	84-93	COP9 signalosome subunit 6	Homo sapiens	155-159
25097228-4	2014	Here, we show that conserved histidine residues in the C-terminal tail also regulate ERp44 in vivo.	Histidine	29-38	endoplasmic reticulum protein 44	Homo sapiens	85-90
25341359-2	2014	Here, we report that two histidine residues separated by a 10-amino-acid spacer (H1068-H1079) located in the juxtamembrane region of c-Met function as a putative novel NLS.	Histidine	25-34	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	133-138
25341359-3	2014	Deletion of these sequences significantly abolished the nuclear translocation of c-Met, as did substitution of the histidines with alanines.	Histidine	115-125	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	81-86
25341359-5	2014	The putative NLS of c-Met is unique in that it relies on histidines, whose positive charge changes depending on pH, rather than the lysines or arginines, commonly found in classical bipartite NLSs, suggesting the possible "pH-dependency" of this NLS.	Histidine	57-67	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	20-25
25170082-0	2014	Mechanisms of mitochondrial holocytochrome c synthase and the key roles played by cysteines and histidine of the heme attachment site, Cys-XX-Cys-His.	Histidine	96-105	holocytochrome c synthase	Homo sapiens	28-53
25170082-7	2014	His-19 (of CXXCH) supplies the second axial ligand to heme in the complex, the first axial ligand was previously shown to be from HCCS residue His-154.	Histidine	0-3	holocytochrome c synthase	Homo sapiens	130-134
25170082-7	2014	His-19 (of CXXCH) supplies the second axial ligand to heme in the complex, the first axial ligand was previously shown to be from HCCS residue His-154.	Histidine	143-146	holocytochrome c synthase	Homo sapiens	130-134
25170082-8	2014	Substitutions of His-19 in cytochrome c to seven other residues (Gly, Ala, Met, Arg, Lys, Cys, and Tyr) were used with various approaches to establish other roles played by His-19.	Histidine	17-20	cytochrome c, somatic	Homo sapiens	27-39
25170082-9	2014	Three roles for His-19 in HCCS-mediated assembly are suggested: (i) to provide the second axial ligand to the heme iron in preparation for covalent attachment; (ii) to spatially position the two cysteinyl sulfurs adjacent to the two heme vinyl groups for thioether formation; and (iii) to aid in release of the holocytochrome c from the HCCS active site.	Histidine	16-19	holocytochrome c synthase	Homo sapiens	26-30
25170082-9	2014	Three roles for His-19 in HCCS-mediated assembly are suggested: (i) to provide the second axial ligand to the heme iron in preparation for covalent attachment; (ii) to spatially position the two cysteinyl sulfurs adjacent to the two heme vinyl groups for thioether formation; and (iii) to aid in release of the holocytochrome c from the HCCS active site.	Histidine	16-19	holocytochrome c synthase	Homo sapiens	337-341
24685714-1	2014	BACKGROUND AND AIMS: Arabinogalactan protein 31 (AGP31) is a remarkable plant cell-wall protein displaying a multi-domain organization unique in Arabidopsis thaliana: it comprises a predicted signal peptide (SP), a short AGP domain of seven amino acids, a His-stretch, a Pro-rich domain and a PAC (PRP-AGP containing Cys) domain.	Histidine	256-259	arabinogalactan protein 31	Arabidopsis thaliana	21-47
24685714-1	2014	BACKGROUND AND AIMS: Arabinogalactan protein 31 (AGP31) is a remarkable plant cell-wall protein displaying a multi-domain organization unique in Arabidopsis thaliana: it comprises a predicted signal peptide (SP), a short AGP domain of seven amino acids, a His-stretch, a Pro-rich domain and a PAC (PRP-AGP containing Cys) domain.	Histidine	256-259	arabinogalactan protein 31	Arabidopsis thaliana	49-54
24685714-11	2014	AGP31 was also found to bind methylesterified polygalacturonic acid, possibly through its His-stretch.	Histidine	90-93	arabinogalactan protein 31	Arabidopsis thaliana	0-5
25193696-4	2014	Our results indicated that both histidine residues (His(13), His(14)) in Abeta1-16 and free histidine enhanced the peroxidase activity of heme, hence His residues were essential in peroxidase activity of Abeta-heme complexes.	Histidine	32-41	amyloid beta precursor protein	Homo sapiens	73-78
25193696-4	2014	Our results indicated that both histidine residues (His(13), His(14)) in Abeta1-16 and free histidine enhanced the peroxidase activity of heme, hence His residues were essential in peroxidase activity of Abeta-heme complexes.	Histidine	52-55	amyloid beta precursor protein	Homo sapiens	73-78
25193696-4	2014	Our results indicated that both histidine residues (His(13), His(14)) in Abeta1-16 and free histidine enhanced the peroxidase activity of heme, hence His residues were essential in peroxidase activity of Abeta-heme complexes.	Histidine	61-64	amyloid beta precursor protein	Homo sapiens	73-78
25193696-4	2014	Our results indicated that both histidine residues (His(13), His(14)) in Abeta1-16 and free histidine enhanced the peroxidase activity of heme, hence His residues were essential in peroxidase activity of Abeta-heme complexes.	Histidine	61-64	amyloid beta precursor protein	Homo sapiens	73-78
25193696-8	2014	However, three of these residues (Arg(5), Tyr(10) and His(13)) identified in this study are all absent in rodents, where rodent Abeta-heme complex lacks peroxidase activity and it does not show AD, implicating the novel significance of these residues as well as human Abeta-heme peroxidase in the pathology of AD.	Histidine	54-57	amyloid beta precursor protein	Homo sapiens	128-133
25238095-1	2014	SLC15A4 is a lysosome-resident, proton-coupled amino-acid transporter that moves histidine and oligopeptides from inside the lysosome to the cytosol of eukaryotic cells.	Histidine	81-90	solute carrier family 15, member 4	Mus musculus	0-7
25054239-6	2014	Previously, we proposed a four-step model describing HCCS-mediated cytochrome c assembly, identifying a conserved histidine residue (His154) as an axial ligand to the heme iron.	Histidine	114-123	holocytochrome c synthase	Homo sapiens	53-57
25401070-1	2014	In this study (S)-3-hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase (H16_A0461/FadB", gene ID: 4247876) from one of two active fatty acid degradation operons of Ralstonia eutropha H16 has been heterologously expressed in Escherichia coli, purified as protein possessing a His-Tag and initially characterized.	Histidine	274-277	H16_RS26975	Ralstonia eutropha H16	18-49
25140899-5	2014	By modulating the amino acid sequence of alpha-synuclein at only two positions in which we introduced a pair of histidine residues found in Abeta, we created a chimeric alpha-synuclein/Abeta peptide with extended ganglioside-binding properties.	Histidine	112-121	amyloid beta precursor protein	Homo sapiens	140-145
25140899-5	2014	By modulating the amino acid sequence of alpha-synuclein at only two positions in which we introduced a pair of histidine residues found in Abeta, we created a chimeric alpha-synuclein/Abeta peptide with extended ganglioside-binding properties.	Histidine	112-121	amyloid beta precursor protein	Homo sapiens	185-190
24833547-7	2014	In addition, the serum concentrations of TNF-alpha, IL-6, C-reactive protein (CRP) and malondialdehyde were significantly reduced and those of superoxide dismutase (SOD) were significantly increased by histidine supplementation when compared with those in obese rats (P&lt; 0 05).	Histidine	202-211	tumor necrosis factor	Rattus norvegicus	41-50
24833547-7	2014	In addition, the serum concentrations of TNF-alpha, IL-6, C-reactive protein (CRP) and malondialdehyde were significantly reduced and those of superoxide dismutase (SOD) were significantly increased by histidine supplementation when compared with those in obese rats (P&lt; 0 05).	Histidine	202-211	interleukin 6	Rattus norvegicus	52-56
24833547-7	2014	In addition, the serum concentrations of TNF-alpha, IL-6, C-reactive protein (CRP) and malondialdehyde were significantly reduced and those of superoxide dismutase (SOD) were significantly increased by histidine supplementation when compared with those in obese rats (P&lt; 0 05).	Histidine	202-211	C-reactive protein	Rattus norvegicus	58-76
24833547-7	2014	In addition, the serum concentrations of TNF-alpha, IL-6, C-reactive protein (CRP) and malondialdehyde were significantly reduced and those of superoxide dismutase (SOD) were significantly increased by histidine supplementation when compared with those in obese rats (P&lt; 0 05).	Histidine	202-211	C-reactive protein	Rattus norvegicus	78-81
24833547-7	2014	In addition, the serum concentrations of TNF-alpha, IL-6, C-reactive protein (CRP) and malondialdehyde were significantly reduced and those of superoxide dismutase (SOD) were significantly increased by histidine supplementation when compared with those in obese rats (P&lt; 0 05).	Histidine	202-211	superoxide dismutase 1	Rattus norvegicus	165-168
24833547-8	2014	Correspondingly, the mRNA expressions of TNF-alpha, IL-6 and CRP in the adipose tissue were significantly down-regulated and that of CuZnSOD was significantly up-regulated by histidine supplementation (P&lt; 0 05).	Histidine	175-184	C-reactive protein	Rattus norvegicus	61-64
24833547-8	2014	Correspondingly, the mRNA expressions of TNF-alpha, IL-6 and CRP in the adipose tissue were significantly down-regulated and that of CuZnSOD was significantly up-regulated by histidine supplementation (P&lt; 0 05).	Histidine	175-184	superoxide dismutase 1	Rattus norvegicus	133-140
24833547-9	2014	Histidine supplementation significantly reduced the HFD-induced translocation of NF-kappaB p65 into the nucleus (P= 0 032) by reducing the phosphorylation of the inhibitor of kappaBalpha in the adipose tissue.	Histidine	0-9	synaptotagmin 1	Rattus norvegicus	91-94
25020048-4	2014	To apply this system to the delivery of HIV antigens, Env gp140 trimers with terminal his-tags (gp140T-his) were anchored to the surface of lipid nanocapsules via Ni-NTA-functionalized lipids.	Histidine	10-13	melanoma antigen	Mus musculus	54-57
25020048-4	2014	To apply this system to the delivery of HIV antigens, Env gp140 trimers with terminal his-tags (gp140T-his) were anchored to the surface of lipid nanocapsules via Ni-NTA-functionalized lipids.	Histidine	86-89	melanoma antigen	Mus musculus	54-57
25221773-0	2014	In silico study of fragile histidine triad interaction domains with MDM2 and p53.	Histidine	27-36	tumor protein p53	Homo sapiens	77-80
25221773-1	2014	BACKGROUND: Fragile histidine triad (FHIT) is considered as a member of the histidine triad (HIT) nucleotide-binding protein superfamily regarded as a putative tumor suppressor executing crucial role in inhibiting p53 degradation by MDM2.	Histidine	20-29	tumor protein p53	Homo sapiens	214-217
25054239-6	2014	Previously, we proposed a four-step model describing HCCS-mediated cytochrome c assembly, identifying a conserved histidine residue (His154) as an axial ligand to the heme iron.	Histidine	114-123	cytochrome c, somatic	Homo sapiens	67-79
25221773-1	2014	BACKGROUND: Fragile histidine triad (FHIT) is considered as a member of the histidine triad (HIT) nucleotide-binding protein superfamily regarded as a putative tumor suppressor executing crucial role in inhibiting p53 degradation by MDM2.	Histidine	76-85	tumor protein p53	Homo sapiens	214-217
25084380-3	2014	In this study, the human TLR6 TIR domain corresponding to amino acids 640-796 was overexpressed in Escherichia coli using engineered C-terminal His tags.	Histidine	144-147	toll like receptor 6	Homo sapiens	25-29
24858299-11	2014	At acidic pH (pH&lt;6.5), ionic and hydrophobic interactions, created by histidine protonation and hydrophobic amino acids, appeared in the Abeta/HSPG binding.	Histidine	73-82	amyloid beta precursor protein	Homo sapiens	140-145
24557708-3	2014	Full-length PrP can bind up to six copper ions; four Cu(II) binding sites are located in the octarepeat domain (residues 60-91), and His-96 and His-111 coordinate two additional copper ions.	Histidine	133-136	prion protein	Homo sapiens	12-15
24557708-3	2014	Full-length PrP can bind up to six copper ions; four Cu(II) binding sites are located in the octarepeat domain (residues 60-91), and His-96 and His-111 coordinate two additional copper ions.	Histidine	144-147	prion protein	Homo sapiens	12-15
25176218-1	2014	Histidine triad nucleotide-binding protein 1 (HINT1) is a member of a superfamily of histidine triad proteins named by the conserved nucleotide-binding motif histidine-x-histidine-x-histidine-xx, in which x represents hydrophobic amino acid.	Histidine	85-94	histidine triad nucleotide binding protein 1	Homo sapiens	0-44
25176218-1	2014	Histidine triad nucleotide-binding protein 1 (HINT1) is a member of a superfamily of histidine triad proteins named by the conserved nucleotide-binding motif histidine-x-histidine-x-histidine-xx, in which x represents hydrophobic amino acid.	Histidine	85-94	histidine triad nucleotide binding protein 1	Homo sapiens	46-51
25176218-1	2014	Histidine triad nucleotide-binding protein 1 (HINT1) is a member of a superfamily of histidine triad proteins named by the conserved nucleotide-binding motif histidine-x-histidine-x-histidine-xx, in which x represents hydrophobic amino acid.	Histidine	158-167	histidine triad nucleotide binding protein 1	Homo sapiens	0-44
25176218-1	2014	Histidine triad nucleotide-binding protein 1 (HINT1) is a member of a superfamily of histidine triad proteins named by the conserved nucleotide-binding motif histidine-x-histidine-x-histidine-xx, in which x represents hydrophobic amino acid.	Histidine	158-167	histidine triad nucleotide binding protein 1	Homo sapiens	46-51
24964018-3	2014	We present mutagenesis, optical, and nuclear magnetic resonance data for the recombinant protein and show that at pH near neutral in the absence of added ligand, THB1 coordinates the heme iron with the canonical proximal histidine and a distal lysine.	Histidine	221-230	uncharacterized protein	Chlamydomonas reinhardtii	162-166
24742626-3	2014	DcpS enzymes are dimers belonging to the Histidine Triad (HIT) superfamily of pyrophosphatases.	Histidine	41-50	decapping enzyme, scavenger	Homo sapiens	0-4
24333324-1	2014	Solute neutral amino acid transporter 5 (SNAT5/SN2) is a member of the System N family, expressed in glial cells in the adult brain, able to transport glutamine, histidine or glycine among other substrates.	Histidine	162-171	solute carrier family 38 member 5	Homo sapiens	41-46
24333324-1	2014	Solute neutral amino acid transporter 5 (SNAT5/SN2) is a member of the System N family, expressed in glial cells in the adult brain, able to transport glutamine, histidine or glycine among other substrates.	Histidine	162-171	solute carrier family 38 member 5	Homo sapiens	47-50
24835629-4	2014	The strong binding affinity of the Ni(II)-IDA complex was successfully used in the covalent labeling and fluorescence bioimaging of a His-tag fused GPCR (G-protein coupled receptor) located on the surface of living cells.	Histidine	134-137	lysophosphatidic acid receptor 2	Homo sapiens	148-152
24835629-4	2014	The strong binding affinity of the Ni(II)-IDA complex was successfully used in the covalent labeling and fluorescence bioimaging of a His-tag fused GPCR (G-protein coupled receptor) located on the surface of living cells.	Histidine	134-137	lysophosphatidic acid receptor 2	Homo sapiens	154-180
24852066-3	2014	L-lysine, L-histidine and L-tryptophan are transported by Gap1 but do not trigger signalling.	Histidine	10-21	amino acid permease GAP1	Saccharomyces cerevisiae S288C	58-62
24699213-4	2014	We found that systemic administration of cyclo(His-Pro) exerts in vivo anti-inflammatory effects in the central nervous system by down-regulating hepatic and cerebral TNFalpha expression thereby counteracting LPS-induced gliosis.	Histidine	47-50	tumor necrosis factor	Homo sapiens	167-175
24699213-6	2014	Moreover, by up-regulating Bip, cyclo(His-Pro) increases the ER stress sensitivity and triggers the unfolded protein response to alleviate the ER stress.	Histidine	38-41	heat shock protein family A (Hsp70) member 5	Homo sapiens	27-30
24828792-7	2014	RESULTS: A variant (cG1553A) was found in a single patient in the GRIN2A gene, causing an arginine to histidine change at site 518, a predicted glutamate binding site.	Histidine	102-111	glutamate ionotropic receptor NMDA type subunit 2A	Homo sapiens	66-72
24742681-5	2014	Two conserved histidine residues in the OSBP homology domain ORP4 are essential for binding phosphatidylinositol 4-phosphate but not sterols.	Histidine	14-23	oxysterol binding protein	Homo sapiens	40-44
24829455-2	2014	However, recent analysis of an Exo1-E109K knockin mouse has concluded that Exo1 function in mammalian mismatch repair is restricted to a structural role, a conclusion based on a prior report that N-terminal His-tagged Exo1-E109K is hydrolytically defective.	Histidine	207-210	exonuclease 1	Mus musculus	31-35
24829455-2	2014	However, recent analysis of an Exo1-E109K knockin mouse has concluded that Exo1 function in mammalian mismatch repair is restricted to a structural role, a conclusion based on a prior report that N-terminal His-tagged Exo1-E109K is hydrolytically defective.	Histidine	207-210	exonuclease 1	Mus musculus	75-79
24742681-5	2014	Two conserved histidine residues in the OSBP homology domain ORP4 are essential for binding phosphatidylinositol 4-phosphate but not sterols.	Histidine	14-23	oxysterol binding protein 2	Homo sapiens	61-65
24534464-3	2014	In this work, a plasmid, pRSET-TEV-rhGH, has been constructed to overexpress recombinant human GH (rhGH) by cloning its gene downstream of an N-terminal 6 x His-tagged polypeptide (43 aa) in the T7 promoter-plasmid pRSET.	Histidine	157-160	growth hormone 1	Homo sapiens	37-39
24832999-2	2014	Here, we report on a versatile strategy to synthesize functionalized graphene oxide nanomaterials with abundant affinity groups that can capture histidine (His)-tagged acetylcholinesterase (AChE) for the fabrication of paraoxon biosensors.	Histidine	145-154	acetylcholinesterase (Cartwright blood group)	Homo sapiens	190-194
24832999-2	2014	Here, we report on a versatile strategy to synthesize functionalized graphene oxide nanomaterials with abundant affinity groups that can capture histidine (His)-tagged acetylcholinesterase (AChE) for the fabrication of paraoxon biosensors.	Histidine	156-159	acetylcholinesterase (Cartwright blood group)	Homo sapiens	190-194
24832999-5	2014	AChE was immobilized on the functionalized graphene oxide (FGO) through the specific binding between Ni-NTA and His-tag.	Histidine	112-115	acetylcholinesterase (Cartwright blood group)	Homo sapiens	0-4
24210555-3	2014	We previously produced a 6x histidine (His)-tagged, mouse FGF4 (Pro(31)-Leu(202)) without a secretory signal peptide at the amino-terminus, referred to as HismFGF4, in Escherichia coli.	Histidine	28-37	fibroblast growth factor 4	Mus musculus	58-62
24624902-8	2014	This was confirmed by in vivo complementation assays, which demonstrated that three highly conserved histidine residues are important for Mrs3p function.	Histidine	101-110	Fe(2+) transporter	Saccharomyces cerevisiae S288C	138-143
24631931-4	2014	Here, we report three-dimensional crystal structures of Na-ASP-2, an L3-secreted activation-associated secreted protein from the human hookworm Necator americanus, which demonstrate transition metal binding ability of the conserved tandem histidine motif.	Histidine	239-248	beta-secretase 1	Homo sapiens	59-64
24631931-5	2014	We further identified moderate phosphohydrolase activity of recombinant Na-ASP-2, which relates to the tandem histidine motif.	Histidine	110-119	beta-secretase 1	Homo sapiens	75-80
24210555-3	2014	We previously produced a 6x histidine (His)-tagged, mouse FGF4 (Pro(31)-Leu(202)) without a secretory signal peptide at the amino-terminus, referred to as HismFGF4, in Escherichia coli.	Histidine	39-42	fibroblast growth factor 4	Mus musculus	58-62
24523414-7	2014	Both (13)C and (15)N SSNMR results show that Cu(+) coordinates to Abeta(1-40) fibrils primarily through the side chain Ndelta of both His-13 and His-14, suggesting major rearrangements from the Cu(2+) coordination via Nepsilon in the redox cycle.	Histidine	134-137	amyloid beta precursor protein	Homo sapiens	66-71
24670063-4	2014	Unlike other DHP structures with 6-coordinated heme, the conformation of the distal histidine (H55) in DHPCO is primarily external or solvent exposed, despite the fact that the heme Fe is 6-coordinated.	Histidine	84-93	dihydropyrimidinase	Homo sapiens	13-16
24670063-5	2014	As observed generally in globins, DHP exhibits two distal histidine conformations (one internal and one external).	Histidine	58-67	dihydropyrimidinase	Homo sapiens	34-37
24670063-7	2014	The large population of the external conformation of the distal histidine observed in DHPCO crystals at pH 6.0 indicates that some structural factor in DHP must account for the difference from other globins, which exhibit a significant external conformation only when pH &lt; 4.5.	Histidine	64-73	dihydropyrimidinase	Homo sapiens	86-89
24523414-7	2014	Both (13)C and (15)N SSNMR results show that Cu(+) coordinates to Abeta(1-40) fibrils primarily through the side chain Ndelta of both His-13 and His-14, suggesting major rearrangements from the Cu(2+) coordination via Nepsilon in the redox cycle.	Histidine	145-148	amyloid beta precursor protein	Homo sapiens	66-71
24398899-3	2014	The experiments identified a strong induction of expression of the gene encoding pyruvate dehydrogenase 4 (PDK4) under the influence of carnosine and L-histidine, but not by the other substances employed.	Histidine	150-161	pyruvate dehydrogenase kinase 4	Homo sapiens	107-111
24398899-6	2014	In addition, enhanced expression of PDK4 under the influence of carnosine/L-histidine opens a new perspective for the interpretation of the ergogenic potential of dietary beta-alanine supplementation and adds a new contribution to a growing body of evidence that single amino acids can regulate key metabolic pathways important in health and disease.	Histidine	74-85	pyruvate dehydrogenase kinase 4	Homo sapiens	36-40
24488754-5	2014	Further reaction of the ruthenium complexes with the oxidized B chain of insulin, in which two cysteine residues are oxidized to cysteine sulfonic acid (Cys-SO3H), and glutathione, which had been oxidized with hydrogen peroxide to convert the cysteine to cysteine sulfonic acid, provided further support for histidine and glutamic acid binding, respectively.	Histidine	308-317	insulin	Homo sapiens	73-80
24589657-0	2014	Proximal FAD histidine residue influences interflavin electron transfer in cytochrome P450 reductase and methionine synthase reductase.	Histidine	13-22	cytochrome p450 oxidoreductase	Homo sapiens	75-100
24589657-0	2014	Proximal FAD histidine residue influences interflavin electron transfer in cytochrome P450 reductase and methionine synthase reductase.	Histidine	13-22	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	105-134
24589657-3	2014	In human CPR, His(322) forms a hydrogen-bond with the highly conserved Asp(677), a member of the catalytic triad.	Histidine	14-17	cytochrome p450 oxidoreductase	Homo sapiens	9-12
24158500-5	2014	The recombinant L. japonica HMGB2 (rLj-HMGB2) with apparent molecular mass of 22 kDa was further purified by His-Bind affinity chromatography.	Histidine	109-112	high mobility group box 2	Homo sapiens	28-33
24488754-4	2014	This initial peptide study was expanded to investigate protein binding through reaction with insulin, on which the binding sites proposed are histidine, glutamic acid, and tyrosine.	Histidine	142-151	insulin	Homo sapiens	93-100
24569140-0	2014	Endoplasmic reticulum microenvironment and conserved histidines govern ELOVL4 fatty acid elongase activity.	Histidine	53-63	ELOVL fatty acid elongase 4	Homo sapiens	71-77
24569140-9	2014	This study shows that ELOVL4 enzymatic activity is governed by individual histidines in its active site and the ER microenvironment, both of which are essential for elongation of VLC-FAs.	Histidine	74-84	ELOVL fatty acid elongase 4	Homo sapiens	22-28
24569140-7	2014	Active site histidine mutants of ELOVL4 did not elongate appropriate precursors, establishing ELOVL4 as the elongase.	Histidine	12-21	ELOVL fatty acid elongase 4	Homo sapiens	33-39
24757411-0	2014	Fragile histidine triad (FHIT) suppresses proliferation and promotes apoptosis in cholangiocarcinoma cells by blocking PI3K-Akt pathway.	Histidine	8-17	AKT serine/threonine kinase 1	Homo sapiens	124-127
24514269-0	2014	Effect of motional restriction on the unfolding properties of a cytochrome c featuring a His/Met-His/His ligation switch.	Histidine	89-92	cytochrome c, somatic	Homo sapiens	64-76
24514269-0	2014	Effect of motional restriction on the unfolding properties of a cytochrome c featuring a His/Met-His/His ligation switch.	Histidine	97-100	cytochrome c, somatic	Homo sapiens	64-76
24514269-0	2014	Effect of motional restriction on the unfolding properties of a cytochrome c featuring a His/Met-His/His ligation switch.	Histidine	97-100	cytochrome c, somatic	Homo sapiens	64-76
24514269-1	2014	The K72A/K73H/K79A variant of cytochrome c undergoes a reversible change from a His/Met to a His/His axial heme ligation upon urea-induced unfolding slightly below neutral pH.	Histidine	80-83	cytochrome c, somatic	Homo sapiens	30-42
24514269-1	2014	The K72A/K73H/K79A variant of cytochrome c undergoes a reversible change from a His/Met to a His/His axial heme ligation upon urea-induced unfolding slightly below neutral pH.	Histidine	93-96	cytochrome c, somatic	Homo sapiens	30-42
24514269-1	2014	The K72A/K73H/K79A variant of cytochrome c undergoes a reversible change from a His/Met to a His/His axial heme ligation upon urea-induced unfolding slightly below neutral pH.	Histidine	93-96	cytochrome c, somatic	Homo sapiens	30-42
24361327-7	2014	The interaction interface of the docking model showed that the amino acids ASN 47, GLU 215, GLY 403 of GRP78 and THR 54, ASN 182 and HIS 184 of NF-kappaB are key residues involved in the docking.	Histidine	133-136	heat shock protein family A (Hsp70) member 5	Homo sapiens	103-108
24361327-7	2014	The interaction interface of the docking model showed that the amino acids ASN 47, GLU 215, GLY 403 of GRP78 and THR 54, ASN 182 and HIS 184 of NF-kappaB are key residues involved in the docking.	Histidine	133-136	nuclear factor kappa B subunit 1	Homo sapiens	144-153
24523290-0	2014	Regulation of the epithelial Ca2+ channel TRPV5 by reversible histidine phosphorylation mediated by NDPK-B and PHPT1.	Histidine	62-71	phosphohistidine phosphatase 1	Homo sapiens	111-116
24486813-9	2014	The N-terminally histidine-tagged ESP4 fusion protein was expressed in Escherichia coli as inclusion bodies, which were solubilized and purified by nickel affinity chromatography.	Histidine	17-26	exocrine gland secreted peptide 4	Mus musculus	34-38
24486813-10	2014	The histidine tag was cleaved with thrombin and removed by a second nickel affinity chromatography step.	Histidine	4-13	coagulation factor II	Mus musculus	35-43
24595206-5	2014	Here we show that our designed series of transition metal-functionalized POM derivatives with a defined histidine-chelated binding site have much better Abeta inhibition and peroxidase-like activity inhibition effects than the parent POM.	Histidine	104-113	amyloid beta precursor protein	Homo sapiens	153-158
24469444-6	2014	At last, this study also allows an accurate structural definition of residues considered for decades as important to the human IgG/FcRn interaction and reveals Fc His(310) as a significant contributor to pH-dependent binding.	Histidine	163-166	Fc gamma receptor and transporter	Homo sapiens	131-135
24412336-4	2014	Some amino acids namely arginine, glycine and histidine showed good retention of catalase functionality after spray drying and subsequent storage stress.	Histidine	46-55	catalase	Homo sapiens	81-89
24390408-4	2014	The alkylated peptides obtained after enzymatic hydrolysis of human SA modified with the different PAHDE were principally PAHDE-His-Pro, PAHDE-His-Pro-Tyr and PAHDE-Lys.	Histidine	128-131	albumin	Homo sapiens	68-70
24488273-3	2014	Histamine suppresses tumor necrosis factor (TNF) production by human myeloid cells and is a product of L-histidine decarboxylation, which is a proton-facilitated reaction.	Histidine	103-114	tumor necrosis factor	Homo sapiens	21-42
24397552-2	2014	This pathway delivers and attaches haem covalently to two cysteines (of Cys-Xxx-Xxx-Cys-His) in the cytochrome c.	Histidine	88-91	cytochrome c, somatic	Homo sapiens	100-112
24586660-4	2014	A novel high throughput screening (HTS) assay based on AlphaLISA  technology was developed to measure the formation of a complex between His-TG2 and the biotinylated FN fragment that binds TG2 and to discover small molecules that inhibit this protein-protein interaction.	Histidine	137-140	fibronectin 1	Homo sapiens	166-168
24442907-0	2014	Multispectroscopic studies on the interaction of a platinum(II) complex containing L-histidine and 1,10-phenanthroline ligands with bovine serum albumin.	Histidine	83-94	albumin	Homo sapiens	139-152
24442907-1	2014	The mechanism of the interaction between bovine serum albumin (BSA) and [Pt(phen) (histidine)](+) complex was studied employing ultraviolet (UV) absorption, circular dichroism (CD), FT-IR, differential pulse voltammetry (DPV), and fluorescence spectral methods.	Histidine	83-92	albumin	Homo sapiens	48-61
24369427-1	2014	RNA Helicase associated with AU-rich element (RHAU) (DHX36) is a DEAH (Aspartic acid, Glumatic Acid, Alanine, Histidine)-box RNA helicase that can bind and unwind G4-quadruplexes in DNA and RNA.	Histidine	110-119	DEAH-box helicase 36	Homo sapiens	0-51
24369427-1	2014	RNA Helicase associated with AU-rich element (RHAU) (DHX36) is a DEAH (Aspartic acid, Glumatic Acid, Alanine, Histidine)-box RNA helicase that can bind and unwind G4-quadruplexes in DNA and RNA.	Histidine	110-119	DEAH-box helicase 36	Homo sapiens	53-58
24437729-3	2014	Here, we report that the histidine-rich domain of selenoprotein P (SelP-H) is capable of binding Cu ions in both oxidation states of Cu(+) and Cu(2+) with high affinity and of modulating Cu(+) and Cu(2+)-mediated Abeta aggregation, reactive oxygen species (ROS) production, and neurotoxicity.	Histidine	25-34	selenoprotein P	Homo sapiens	50-65
24161853-0	2014	Study on the interaction between histidine-capped Au nanoclusters and bovine serum albumin with spectroscopic techniques.	Histidine	33-42	albumin	Homo sapiens	77-90
24252720-5	2014	We present here the use of the HR-MAS technology to obtain 2D NMR spectra of the MAGI-1 PDZ2/6 protein domain, C13-labeled, tagged with a His-tag and grafted on a Nickel affinity resin.	Histidine	138-141	membrane associated guanylate kinase, WW and PDZ domain containing 1	Homo sapiens	81-87
23791559-9	2014	In addition, histidine, the precursor of histamine, also showed neuroprotection against ischemic injury, which was accompanied by reversion of declined expression of GLT-1 in adult rats subjected to middle cerebral artery occlusion (MCAO).	Histidine	13-22	solute carrier family 1 member 2	Rattus norvegicus	166-171
23791559-10	2014	These neuroprotective effects of histamine/histidine were blocked by GLT-1 specific inhibitor dihydrokainate or H1 receptor antagonist.	Histidine	43-52	solute carrier family 1 member 2	Rattus norvegicus	69-74
24647109-7	2014	Solubilized His-tagged scFv proteins were purified using Ni(2+)-Sepharose column chromatography in the presence of 3.5 M Gdn-HCl.	Histidine	12-15	immunglobulin heavy chain variable region	Homo sapiens	23-27
24161853-2	2014	In this manuscript, the interaction of histidine-capped Au nanoclusters (NCs) with bovine serum albumin (BSA) has been investigated by fluorescence, UV-vis, circular dichroism (CD) and Raman spectroscopic techniques under simulative physiological conditions.	Histidine	39-48	albumin	Homo sapiens	90-103
23948240-1	2014	In this work, we fabricated a novel photoelectrochemical immunosensor for assay of DNA methylation, where Bi2S3 nanorods were used as photoelectric conversion material, MBD1 protein (a kind of methyl bonding domain protein) was used as DNA methylation recognizing unit, anti-his tag antibody was used to further inhibit the photocurrent and increase the detection sensitivity.	Histidine	4-7	methyl-CpG binding domain protein 1	Homo sapiens	169-173
24354419-3	2014	The chemical reactivities of free His, Trp, and Tyr and of their acetylated derivatives, N-AcHis, N-AcTyr, and N-AcTrp, toward TCBP triplets are compared to reveal the influence of amino group charge on the oxidation of aromatic amino acids.	Histidine	34-37	TIA1 cytotoxic granule associated RNA binding protein like 1	Homo sapiens	127-131
24354419-6	2014	Thus, it has been established that the presence of charged amino group changes oxidation rates by a significant factor; i.e., His with a positively charged amino group quenches the TCBP triplets 5 times more effectively than N-AcHis and His with a neutral amino group.	Histidine	126-129	TIA1 cytotoxic granule associated RNA binding protein like 1	Homo sapiens	181-185
24369116-4	2014	Our results show considerable differences in H43R compared to WT and W32F mutated SOD1, such as increasing distances between the critical residues results in open conformation at the active site, strong fluctuations in the important loops (Zinc and electrostatic loops) and weakening of important hydrogen bonds especially between N (His 43/Arg 43) and carbonyl oxygen (His 120) in agreement with the experimental report.	Histidine	334-337	superoxide dismutase 1	Homo sapiens	82-86
24282278-7	2014	Recombinant MDA-7/IL-24 (His-MDA-7) induces SARI expression, supporting the involvement of SARI in the MDA-7/IL-24-driven autocrine loop, culminating in antitumor effects.	Histidine	25-28	basic leucine zipper ATF-like transcription factor 2	Homo sapiens	44-48
24282278-7	2014	Recombinant MDA-7/IL-24 (His-MDA-7) induces SARI expression, supporting the involvement of SARI in the MDA-7/IL-24-driven autocrine loop, culminating in antitumor effects.	Histidine	25-28	basic leucine zipper ATF-like transcription factor 2	Homo sapiens	91-95
24803226-5	2014	In addition to Abeta peptides starting with an Asp at position 1, a variety of different N-truncated Abeta peptides have been identified starting with amino residue Ala-2, pyroglutamylated Glu-3, Phe-4, Arg-5, His-6, Asp-7, Ser-8, Gly-9, Tyr-10 and pyroglutamylated Glu-11.	Histidine	210-213	amyloid beta precursor protein	Homo sapiens	101-106
25215298-6	2014	Moreover, we conducted p53 mutation analysis and revealed a mutation at codon 273 which led to the replacement of arginine by histidine.	Histidine	126-135	tumor protein p53	Homo sapiens	23-26
25015797-11	2014	NO binds to the ferrous (Fe(2+)) heme at histidine 105 of the beta1 subunit and leads to an increase in sGC activity and cGMP production of at least 200-fold.	Histidine	41-50	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	62-67
24068478-3	2014	Here, we found that bacterially expressed, 6x histidine (His)-tagged human FGF4 (Pro(32)-Leu(206)) protein, referred to as HishFGF4, was unstable such as in phosphate-buffered saline.	Histidine	46-55	fibroblast growth factor 4	Homo sapiens	75-79
24068478-3	2014	Here, we found that bacterially expressed, 6x histidine (His)-tagged human FGF4 (Pro(32)-Leu(206)) protein, referred to as HishFGF4, was unstable such as in phosphate-buffered saline.	Histidine	57-60	fibroblast growth factor 4	Homo sapiens	75-79
24068478-5	2014	In order to generate stable human FGF4 derivatives, a 6x His-tagged human FGF4 (Leu(55)-Leu(206)), termed HishFGF4L, was expressed in Escherichia coli.	Histidine	57-60	fibroblast growth factor 4	Homo sapiens	34-38
24068478-5	2014	In order to generate stable human FGF4 derivatives, a 6x His-tagged human FGF4 (Leu(55)-Leu(206)), termed HishFGF4L, was expressed in Escherichia coli.	Histidine	57-60	fibroblast growth factor 4	Homo sapiens	74-78
24101560-7	2014	The conserved region of Delta6-fatty acid desaturase included three conserved histidine-rich domain, hydropathy profile, and was rich in disulfide bonds.	Histidine	78-87	fatty acid desaturase 2	Homo sapiens	30-52
24121108-11	2014	CONCLUSIONS: These results propose that the function of mammalian NAT16 has been altered from l-His acetylation (NAH synthesis) to another different biological role.	Histidine	94-99	N-acetyltransferase 16 (putative)	Homo sapiens	66-71
24369116-4	2014	Our results show considerable differences in H43R compared to WT and W32F mutated SOD1, such as increasing distances between the critical residues results in open conformation at the active site, strong fluctuations in the important loops (Zinc and electrostatic loops) and weakening of important hydrogen bonds especially between N (His 43/Arg 43) and carbonyl oxygen (His 120) in agreement with the experimental report.	Histidine	370-373	superoxide dismutase 1	Homo sapiens	82-86
24449363-4	2014	We detected an association between HNC and CYP1A1 6310C&gt;T (TT) and CYP2D6 Arg365His (His/His) variant carriers (OR 1.75, P = 0.008 and OR 1.66, P = 0.016, respectively).	Histidine	83-86	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	70-76
23932357-1	2014	Increasing concentration of histidine significantly increased stearidonic acid production and cell growth in oleaginous Saccharomyces cerevisiae that has been genetically modified by Deltasnf2 disruption, DGA1 and Delta6 desaturase gene overexpression, and LEU2 expression.	Histidine	28-37	3-isopropylmalate dehydrogenase	Saccharomyces cerevisiae S288C	257-261
25345515-8	2014	His-121, Ser-205, Arg-207 which were found to be playing crucial role in the binding of the selected compounds within the active site of caspase-3.	Histidine	0-3	caspase 3	Homo sapiens	137-146
24449363-4	2014	We detected an association between HNC and CYP1A1 6310C&gt;T (TT) and CYP2D6 Arg365His (His/His) variant carriers (OR 1.75, P = 0.008 and OR 1.66, P = 0.016, respectively).	Histidine	88-91	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	70-76
24492416-4	2014	Remarkably, in full-length STIM1, replacement of Phe-394 with the dimensionally similar but polar histidine head group prevents both Orai1 binding and gating, creating an Orai1 non-agonist.	Histidine	98-107	stromal interaction molecule 1	Homo sapiens	27-32
24167195-4	2013	Coexpression of the Dnmt3a R878H (histidine) mutant protein results in inhibition of the ability of wild-type Dnmt3a and Dnmt3b to methylate DNA in murine ES cells.	Histidine	34-43	DNA methyltransferase 3A	Mus musculus	20-26
24178578-4	2014	Most p110alpha mutations occur at two hot spot regions: an acidic cluster (E542, E545, and Q546) in the helical domain and a histidine residue (H1047) in the kinase domain.	Histidine	125-134	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	5-14
24274590-6	2013	The results suggest that the (1)O2 accessibility of residues in intact GAPDH has a profound effect on their photodegradation kinetics and for histidine residues can explain most of the variation in (1)O2 reactivity.	Histidine	142-151	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	71-76
24274576-1	2013	Recent evidence shows that metal coordination by amyloid beta peptides (Abeta) determines structural alterations of peptides, and His-13 from Abeta is crucial for Cu(2+) binding.	Histidine	130-133	amyloid beta precursor protein	Homo sapiens	142-147
23872610-1	2013	Here we report a novel electrochemiluminescence (ECL) immunosensor for ultrasensitive detection of carcinoembryonic antigen (CEA) via histidine labeled supersandwich DNA structure to amplify the ECL signal.	Histidine	134-143	CEA cell adhesion molecule 3	Homo sapiens	99-123
23872610-1	2013	Here we report a novel electrochemiluminescence (ECL) immunosensor for ultrasensitive detection of carcinoembryonic antigen (CEA) via histidine labeled supersandwich DNA structure to amplify the ECL signal.	Histidine	134-143	CEA cell adhesion molecule 3	Homo sapiens	125-128
24167195-4	2013	Coexpression of the Dnmt3a R878H (histidine) mutant protein results in inhibition of the ability of wild-type Dnmt3a and Dnmt3b to methylate DNA in murine ES cells.	Histidine	34-43	DNA methyltransferase 3A	Mus musculus	110-116
24167195-4	2013	Coexpression of the Dnmt3a R878H (histidine) mutant protein results in inhibition of the ability of wild-type Dnmt3a and Dnmt3b to methylate DNA in murine ES cells.	Histidine	34-43	DNA methyltransferase 3B	Mus musculus	121-127
24289163-10	2013	Deletion of three amino acids in a consensus linker (TGEKP &gt; TG) between finger-7 and the 6 x Histidine-tag in the C-terminal also dramatically abolished their binding affinity.	Histidine	97-106	Yip1 interacting factor homolog A, membrane trafficking protein	Homo sapiens	76-84
23978331-2	2013	A detailed study of the pH dependence of the midpoint potential of skeletal horse myoglobin (Mb) with a heme-bound fluoride ion (Mb-F) reveals how protonation of the distal histidine (H64) changes the redox properties of the protein with a determined pKa of 5.3.	Histidine	173-182	myoglobin	Equus caballus	82-91
23978331-2	2013	A detailed study of the pH dependence of the midpoint potential of skeletal horse myoglobin (Mb) with a heme-bound fluoride ion (Mb-F) reveals how protonation of the distal histidine (H64) changes the redox properties of the protein with a determined pKa of 5.3.	Histidine	173-182	myoglobin	Equus caballus	93-95
23978331-2	2013	A detailed study of the pH dependence of the midpoint potential of skeletal horse myoglobin (Mb) with a heme-bound fluoride ion (Mb-F) reveals how protonation of the distal histidine (H64) changes the redox properties of the protein with a determined pKa of 5.3.	Histidine	173-182	myoglobin	Equus caballus	129-131
24123819-1	2013	Human microbiome-derived strains of Lactobacillus reuteri potently suppress proinflammatory cytokines like human tumor necrosis factor (TNF) by converting the amino acid l-histidine to the biogenic amine histamine.	Histidine	170-181	tumor necrosis factor	Homo sapiens	113-134
24123819-1	2013	Human microbiome-derived strains of Lactobacillus reuteri potently suppress proinflammatory cytokines like human tumor necrosis factor (TNF) by converting the amino acid l-histidine to the biogenic amine histamine.	Histidine	170-181	tumor necrosis factor	Homo sapiens	136-139
23666425-8	2013	This NO acts on the RGSZ2 zinc finger, providing the zinc ions that are required for PKC/Raf-1 cysteine-rich domains to simultaneously bind to the histidines present in the HINT1 homodimer.	Histidine	147-157	histidine triad nucleotide binding protein 1	Homo sapiens	173-178
24148431-3	2013	Thrombin can selectively digest EGFP accompanied by His-tag peptide sequence leaving, and the resulting EGFP cannot be captured by Ni(2+)-NTA MNPs and kept in supernatant.	Histidine	52-55	coagulation factor II, thrombin	Homo sapiens	0-8
24152914-6	2013	When Cu,Zn-SOD that has been exposed to acrolein was subsequently analyzed by amino acid analysis, serine, histidine, arginine, threonine and lysine residues were particularly sensitive.	Histidine	107-116	superoxide dismutase 1	Homo sapiens	11-14
24244337-0	2013	Protein A-mouse acidic mammalian chitinase-V5-His expressed in periplasmic space of Escherichia coli possesses chitinase functions comparable to CHO-expressed protein.	Histidine	46-49	chitinase, acidic 1	Mus musculus	16-42
23973283-5	2013	F. hepatica TPI is predicted to have a beta-barrel structure and key active site residues (Lys-14, His-95 and Glu-165) are conserved.	Histidine	99-102	triosephosphate isomerase 1	Homo sapiens	12-15
24037720-8	2013	The Cu(2+) ligands in the most stable Cu(2+)-Abeta(1-16) structure involve Glu(3) , His(6) , His(13) and His(14) in terms of MM/3D-RISM (molecular mechanics/three-dimensional reference interaction site model).	Histidine	84-87	amyloid beta precursor protein	Homo sapiens	45-50
24037720-8	2013	The Cu(2+) ligands in the most stable Cu(2+)-Abeta(1-16) structure involve Glu(3) , His(6) , His(13) and His(14) in terms of MM/3D-RISM (molecular mechanics/three-dimensional reference interaction site model).	Histidine	93-96	amyloid beta precursor protein	Homo sapiens	45-50
24037720-8	2013	The Cu(2+) ligands in the most stable Cu(2+)-Abeta(1-16) structure involve Glu(3) , His(6) , His(13) and His(14) in terms of MM/3D-RISM (molecular mechanics/three-dimensional reference interaction site model).	Histidine	93-96	amyloid beta precursor protein	Homo sapiens	45-50
23871971-6	2013	The change in the relative position of His 74 to heme induced by the variation of secondary structure is considered to be the major reason for the reduction of CAT activity.	Histidine	39-42	catalase	Homo sapiens	160-163
24090437-3	2013	In the ternary systems with the insulin-enhancing compounds, mixed species are observed with Hma, Hdhp, and Hpic with the formation of VOL2(holo-hTf), explained through the interaction of cis-[VOL2(H2O)] (L = ma, dhp) or cis-[VOL2(OH)](-) (L = pic) with an accessible His residue that replaces the monodentate H2O or OH(-) ligand.	Histidine	268-271	insulin	Homo sapiens	32-39
24018234-3	2013	Using a DE3 derivative strain expressing tRNAs for seven rare codons in E. coli called Rosetta2 (DE3), a large quantity of soluble human 6PGD can be expressed with an N-terminal histidine tag and purified by a one-step purification procedure to near homogeneity without denaturants or refolding.	Histidine	178-187	phosphogluconate dehydrogenase	Homo sapiens	137-141
23863845-1	2013	A p53 hot-spot mutation found frequently in human cancer is the replacement of R273 by histidine or cysteine residues resulting in p53 loss of function as a tumor suppressor.	Histidine	87-96	tumor protein p53	Homo sapiens	2-5
23955493-0	2013	H-loop histidine catalyzes ATP hydrolysis in the E. coli ABC-transporter HlyB.	Histidine	7-16	hemolysin transport protein	Escherichia coli	73-77
23747062-2	2013	Sequence comparisons among these proteins, and CaPRP1 from Capsicum annuum, reveal a conserved histidine-rich domain and two hypervariable domains.	Histidine	95-104	pistil-specific extensin-like protein	Capsicum annuum	47-53
23863845-1	2013	A p53 hot-spot mutation found frequently in human cancer is the replacement of R273 by histidine or cysteine residues resulting in p53 loss of function as a tumor suppressor.	Histidine	87-96	tumor protein p53	Homo sapiens	131-134
23902765-3	2013	Here, we show that RNA binding mediated by either isolated RRM3 or the RRM23 construct is controlled by slight environmental pH changes due to the protonation/deprotonation of TIA-1 RRM3 histidine residues.	Histidine	187-196	TIA1 cytotoxic granule associated RNA binding protein	Homo sapiens	176-181
23609990-4	2013	The structure demonstrates that Abeta residues 10-16, which are not in complex with the antibody, adopt a mixture of local polyproline II-helix and turn type conformations, enhancing cooperativity between the two adjacent histidine residues His13 and His14.	Histidine	222-231	amyloid beta precursor protein	Homo sapiens	32-37
24044701-16	2013	This phenotype was similar to the effects obtained upon treatment with fungicides, as in both cases growth inhibition correlated with Hog1p activation and was dependent on the functionality of the conserved phosphate-accepting histidine residue.	Histidine	227-236	mitogen-activated protein kinase HOG1	Saccharomyces cerevisiae S288C	134-139
23884414-8	2013	Furthermore, inhibition by 30 muM ZnCl2 was impaired in TRPM5 mutants in which His at 896, and Glu at 926 and/or Glu at 939 in the outer pore loop were replaced with Gln.	Histidine	79-82	latexin	Homo sapiens	30-33
23958318-6	2013	In contrast, IGF-I integrity was preserved in histidine buffer during accelerated stability.	Histidine	46-55	insulin like growth factor 1	Homo sapiens	13-18
23747845-6	2013	The role of pre-protonation and electrostatic stabilization by histidine (His440(+)) in catalyzing the aging process of soman inhibited AChE is energetically comparable.	Histidine	63-72	acetylcholinesterase (Cartwright blood group)	Homo sapiens	136-140
23905516-11	2013	In other systems, such as iNOS and CYP3A4 (where the HXC-Fe motif is not found), a somewhat larger conformational change would be necessary to recuit a nearby histidine.	Histidine	159-168	nitric oxide synthase 2	Homo sapiens	26-30
23905516-11	2013	In other systems, such as iNOS and CYP3A4 (where the HXC-Fe motif is not found), a somewhat larger conformational change would be necessary to recuit a nearby histidine.	Histidine	159-168	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	35-41
23777370-2	2013	In this work, we extended our previous study on the highly conserved TPLH tetrapeptide and investigated the impact of a solvent-exposed histidine residue on the pH-dependent stability of gankyrin, providing further insight into the contribution of the TPLH motif to the tertiary fold of AR proteins.	Histidine	136-145	proteasome 26S subunit, non-ATPase 10	Homo sapiens	187-195
23831576-1	2013	The transcriptional co-regulator CBP (CREB-binding protein) has a highly conserved cysteine/histidine-rich region (CH2) whose structure and function remain uncharacterized.	Histidine	92-101	CREB binding protein	Homo sapiens	33-36
23831576-1	2013	The transcriptional co-regulator CBP (CREB-binding protein) has a highly conserved cysteine/histidine-rich region (CH2) whose structure and function remain uncharacterized.	Histidine	92-101	CREB binding protein	Homo sapiens	38-58
23849042-5	2013	The mechanism of Dox-mediated iPLA2 inhibition was evaluated using purified 6x histidine-tagged enzyme.	Histidine	79-88	phospholipase A2, group VI	Mus musculus	30-35
23490644-3	2013	Using three model proteins, histidine hexamer (His6), glutathione S-transferase (GST) and antibody fragment, we confirmed that Oct-1 DBD fused proteins were strongly linked to plasmids and their linking were conserved for entire process of in vitro selection.	Histidine	28-37	solute carrier family 22 member 1	Homo sapiens	127-132
23777370-3	2013	Consisting of seven ARs, gankyrin has five histidine residues in TPLH motifs or its variants, all of which adopt a H(epsilon2)-tautermeric form and are shielded from solvent.	Histidine	43-52	proteasome 26S subunit, non-ATPase 10	Homo sapiens	25-33
23689251-2	2013	The complex LAl(3+) is a turn-on selective fluorescent probe for histidine in HEPES buffer, with detection and quantification limits of 0.3 muM and 0.6 muM, respectively.	Histidine	65-74	latexin	Homo sapiens	140-143
23689251-2	2013	The complex LAl(3+) is a turn-on selective fluorescent probe for histidine in HEPES buffer, with detection and quantification limits of 0.3 muM and 0.6 muM, respectively.	Histidine	65-74	latexin	Homo sapiens	152-155
32481827-3	2013	The scFv was genetically engineered to introduce a cysteine residue inside the loop sequence bridging the VH and VL lobes of the molecule and a histidine tag at the C-terminus in the VL fragment.	Histidine	144-153	immunglobulin heavy chain variable region	Homo sapiens	4-8
23790103-2	2013	In addition to pyridoxal phosphate, human CBS has a heme cofactor with cysteine and histidine as ligands.	Histidine	84-93	cystathionine beta-synthase	Homo sapiens	42-45
32481827-4	2013	The Cys and 6 x His functionalities were exploited as orthogonal reactive groups driving the scFv conjugation to MNPs.	Histidine	16-19	immunglobulin heavy chain variable region	Homo sapiens	93-97
23525969-0	2013	The role of cysteines and histidins of the norepinephrine transporter.	Histidine	26-35	solute carrier family 6 member 2	Homo sapiens	43-69
23685476-5	2013	The truncated EBNA1 (E1DeltaGA, codons 390-641) was expressed as a secretory protein with an N-terminal histidine tag in the methylotrophic yeast P. pastoris and purified by Ni-NTA affinity chromatography.	Histidine	104-113	EBNA-1	Human gammaherpesvirus 4	14-19
23466546-0	2013	Preparation of poly(hydroxyethyl methacrylate) cryogels containing L-histidine for insulin recognition.	Histidine	67-78	insulin	Homo sapiens	83-90
23474485-3	2013	Here, we show that increased plasma histidine results in hepatic STAT3 activation.	Histidine	36-45	signal transducer and activator of transcription 3	Mus musculus	65-70
23474485-4	2013	Intravenous and intracerebroventricular (ICV) administration of histidine-activated hepatic STAT3 reduced G6Pase protein and mRNA levels and augmented HGP suppression by insulin.	Histidine	64-73	signal transducer and activator of transcription 3	Mus musculus	92-97
23474485-7	2013	Therefore, histidine activates hepatic STAT3 and suppresses HGP via central histamine action.	Histidine	11-20	signal transducer and activator of transcription 3	Mus musculus	39-44
23652317-1	2013	Previous studies on engineered CuA centres have shown that one of the histidine ligands is protonated and dissociated from the metal site at physiological pH values, thus suggesting a role in regulating proton-coupled electron transfer of cytochrome c oxidases in vivo.	Histidine	70-79	cytochrome c, somatic	Homo sapiens	239-251
23692562-2	2013	Extending a recombinantly produced HER2 binding affibody molecule with a hexa-histidine tag allows for convenient purification by immobilized metal-ion affinity chromatography and labeling with [(99m)Tc(CO)3](+) but increases radioactivity uptake in the liver.	Histidine	78-87	erb-b2 receptor tyrosine kinase 2	Homo sapiens	35-39
23692562-3	2013	To investigate the impact of charge, lipophilicity, and position on biodistribution, 10 variants of a histidine-based tag was attached to a HER2 binding affibody molecule.	Histidine	102-111	erb-b2 receptor tyrosine kinase 2	Homo sapiens	140-144
23640895-2	2013	Unlike canonical FGFRs that initiate signaling via tyrosine kinase domains, the short intracellular sequence of FGFRL1 consists of a putative Src homology domain-2 (SH2)-binding motif adjacent to a histidine-rich C terminus.	Histidine	198-207	fibroblast growth factor receptor-like 1	Mus musculus	112-118
23564659-4	2013	On the basis of a peptide reported in the literature, referred to here as the Parent Peptide (H-Aib-Val-Aib-Glu-Ile-Gln-Leu-Nle-His-Gln-Har-NH2), we conducted systematic SAR analyses to investigate the effects of altering peptide hydrophobicity on PTH receptor functional potency as measured by the cAMP (cyclic adenosine monophosphate) accumulation and beta-arrestin recruitment assays.	Histidine	128-131	parathyroid hormone	Homo sapiens	248-251
23631528-1	2013	Amphiphilic peptides were designed to fold into a beta-sheet monolayer structure while presenting the catalytic triad residues of the enzyme, acetylcholinesterase (Glu, His, and Ser), to a solution containing the organophosphate, paraoxon.	Histidine	169-172	acetylcholinesterase (Cartwright blood group)	Homo sapiens	142-162
23631528-6	2013	Circular dichroism revealed that the peptide most sensitive to interactions with paraoxon was that with the triad residues in the order Glu, Ser, and His, which appears to be appropriate for supporting a catalytic mechanism similar to that in the acetylcholinesterase enzyme.	Histidine	150-153	acetylcholinesterase (Cartwright blood group)	Homo sapiens	247-267
23591681-10	2013	RPS23 was successfully expressed in E. coli and its protein fused with the N-terminal His-tagged protein triggered the accumulation of an expected 21.5-kDa polypeptide.	Histidine	86-89	40S ribosomal protein S23	Ailuropoda melanoleuca	0-5
23652332-5	2013	Here, we reported that the His-rich domain of selenoprotein P (SelP-H) and the Sec-to-Cys mutant selenoprotein M (SelM") are capable of binding transition metal ions and modulating the Zn(2+)-mediated Abeta aggregation, ROS production and neurotoxicity.	Histidine	27-30	selenoprotein P	Homo sapiens	46-61
23589050-4	2013	In the present study, purified prokaryotic native His-apoptin served as a bait for capturing apoptin-associated proteins in both a hepatoma carcinoma cell line (HepG2) and a human fetal liver cell line (L-02).	Histidine	50-53	APOPTIN;hypothetical protein;nucleocapsid protein	Chicken anemia virus	54-61
23589050-4	2013	In the present study, purified prokaryotic native His-apoptin served as a bait for capturing apoptin-associated proteins in both a hepatoma carcinoma cell line (HepG2) and a human fetal liver cell line (L-02).	Histidine	50-53	APOPTIN;hypothetical protein;nucleocapsid protein	Chicken anemia virus	93-100
23586470-5	2013	The coupling of histidine-tagged Xenopus cadherin 11 (Xcad-11) can also be identified by changes in the fines-structures using XRR.	Histidine	16-25	cadherin 11 L homeolog	Xenopus laevis	33-52
23704982-1	2013	Bacterial tRNA-guanine transglycosylase (Tgt) catalyses the exchange of the genetically encoded guanine at the wobble position of tRNAs(His,Tyr,Asp,Asn) by the premodified base preQ1, which is further converted to queuine at the tRNA level.	Histidine	136-139	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	10-39
23704982-1	2013	Bacterial tRNA-guanine transglycosylase (Tgt) catalyses the exchange of the genetically encoded guanine at the wobble position of tRNAs(His,Tyr,Asp,Asn) by the premodified base preQ1, which is further converted to queuine at the tRNA level.	Histidine	136-139	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	41-44
23671581-4	2013	Here, we document, for the first time, that the aminocoumarin antibiotic, novobiocin, directly blocks the protein-protein interaction between the HIF1alpha C-terminal activation domain (CTAD) and the cysteine-histidine rich (CH1) region of p300/CBP.	Histidine	209-218	hypoxia inducible factor 1 subunit alpha	Homo sapiens	146-155
23671581-4	2013	Here, we document, for the first time, that the aminocoumarin antibiotic, novobiocin, directly blocks the protein-protein interaction between the HIF1alpha C-terminal activation domain (CTAD) and the cysteine-histidine rich (CH1) region of p300/CBP.	Histidine	209-218	CREB binding protein	Homo sapiens	245-248
23614869-11	2013	Introducing a histidine into the interface of procaspase-3 prevents activation by acting as a negative design element, providing evidence that the interface region is a site of regulation of caspase assembly in general by affecting the rate of dimerization.	Histidine	14-23	caspase 3	Homo sapiens	46-58
23525108-2	2013	We monitored the cAMP-dependent changes in the structure of the C-helix of a C-terminal fragment of HCN2 channels using transition metal ion FRET between fluorophores on the C-helix and metal ions bound between histidine pairs on the same helix.	Histidine	211-220	hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2	Homo sapiens	100-104
23586470-5	2013	The coupling of histidine-tagged Xenopus cadherin 11 (Xcad-11) can also be identified by changes in the fines-structures using XRR.	Histidine	16-25	cadherin 11 L homeolog	Xenopus laevis	54-61
23545653-2	2013	In this study, the CARD domain of human CARMA1 (CARMA1 CARD), corresponding to amino acids 14-109, was overexpressed in Escherichia coli using an engineered C-terminal His tag.	Histidine	168-171	caspase recruitment domain family member 11	Homo sapiens	40-46
23250353-2	2013	Recently, the Ni(2+)-binding site with critical histidine-191 (H191) within the extracellular IS3-IS4 domain of the most Ni(2+)-sensitive Cav3.2 T-channel isoform has been identified.	Histidine	48-57	caveolin 3, gene 2 S homeolog	Xenopus laevis	138-144
23361591-0	2013	Histidine supplementation improves insulin resistance through suppressed inflammation in obese women with the metabolic syndrome: a randomised controlled trial.	Histidine	0-9	insulin	Homo sapiens	35-42
23447530-6	2013	The inactive [HisB24]-insulin molecule is remarkably rigid due to a tight accommodation of the L-His side chain in the B24 binding pocket that results in the stronger tethering of B25-B28 residues to the protein core.	Histidine	95-100	insulin	Homo sapiens	22-29
23447530-7	2013	In contrast, the highly active [D-HisB24]-insulin is more flexible, and the reverse chirality of the B24C(alpha) atom swayed the D-His(B24) side chain into the solvent.	Histidine	34-37	insulin	Homo sapiens	42-49
23448204-8	2013	Mass spectrometric analysis of 12-sulfoxyl-NVP-treated HSA revealed that the drug bound selectively to histidine (His146, His242, and His338) and a cysteine residue (Cys34).	Histidine	103-112	albumin	Homo sapiens	55-58
23545653-2	2013	In this study, the CARD domain of human CARMA1 (CARMA1 CARD), corresponding to amino acids 14-109, was overexpressed in Escherichia coli using an engineered C-terminal His tag.	Histidine	168-171	caspase recruitment domain family member 11	Homo sapiens	48-54
22959014-3	2013	Then, the histidine labeled thrombin aptamer was immobilized onto the electrode through coordination of the histidine groups on the NTA-Cu(2+) complex.	Histidine	10-19	coagulation factor II, thrombin	Homo sapiens	28-36
22959014-3	2013	Then, the histidine labeled thrombin aptamer was immobilized onto the electrode through coordination of the histidine groups on the NTA-Cu(2+) complex.	Histidine	108-117	coagulation factor II, thrombin	Homo sapiens	28-36
23467560-7	2013	In vitro studies showed that amino acids such as cysteine, histidine, arginine, and lysine, as well as other nucleophiles such as taurine, inhibited cyanate-induced C-Alb formation at physiologic pH and temperature.	Histidine	59-68	albumin	Homo sapiens	167-170
23289528-5	2013	Recent research has shown that heme binds preferentially to the His(13) residue of Abeta with the iron center, while the hydrophobic domain of Abeta is also able to bind to heme.	Histidine	64-67	amyloid beta precursor protein	Homo sapiens	83-88
23415437-4	2013	APOA-I gene sequencing revealed a novel heterozygous in-frame insertion mutation with duplication of nucleotides 1535 through 1552 inserted at position 1553, causing a new amino acid glycine at codon 157 and a duplication of amino acids alanine, arginine, alanine, histidine, and leucine at codons 158-162.	Histidine	265-274	apolipoprotein A1	Homo sapiens	0-6
23150584-5	2013	A conserved histidine in HCCS (His154) provided the key ligand to the heme iron.	Histidine	12-21	holocytochrome c synthase	Homo sapiens	25-29
23150584-6	2013	Formation of the HCCS:heme complex served as the platform for interaction with apocytochrome c. Heme was the central molecule mediating contact between HCCS and apocytochrome c. A conserved histidine in apocytochrome c (His19 of CXXCH) supplied the second axial ligand to heme in the trapped HCCS:heme:cytochrome c complex.	Histidine	190-199	holocytochrome c synthase	Homo sapiens	17-21
23150584-6	2013	Formation of the HCCS:heme complex served as the platform for interaction with apocytochrome c. Heme was the central molecule mediating contact between HCCS and apocytochrome c. A conserved histidine in apocytochrome c (His19 of CXXCH) supplied the second axial ligand to heme in the trapped HCCS:heme:cytochrome c complex.	Histidine	190-199	holocytochrome c synthase	Homo sapiens	152-156
23150584-6	2013	Formation of the HCCS:heme complex served as the platform for interaction with apocytochrome c. Heme was the central molecule mediating contact between HCCS and apocytochrome c. A conserved histidine in apocytochrome c (His19 of CXXCH) supplied the second axial ligand to heme in the trapped HCCS:heme:cytochrome c complex.	Histidine	190-199	holocytochrome c synthase	Homo sapiens	152-156
23150584-6	2013	Formation of the HCCS:heme complex served as the platform for interaction with apocytochrome c. Heme was the central molecule mediating contact between HCCS and apocytochrome c. A conserved histidine in apocytochrome c (His19 of CXXCH) supplied the second axial ligand to heme in the trapped HCCS:heme:cytochrome c complex.	Histidine	190-199	cytochrome c, somatic	Homo sapiens	82-94
23289528-5	2013	Recent research has shown that heme binds preferentially to the His(13) residue of Abeta with the iron center, while the hydrophobic domain of Abeta is also able to bind to heme.	Histidine	64-67	amyloid beta precursor protein	Homo sapiens	143-148
22446793-3	2013	CES2 secretion to the media was achieved by the simple addition of an in-frame C-terminal 10x histidine tag (CES2-10xHis) without the need of addition of extra N-terminal signalling sequences or the mutation or deletion of the C-terminal HTEL motif responsible for retaining the protein in the lumen of endoplasmic reticulum.	Histidine	94-103	carboxylesterase 2	Homo sapiens	0-4
23385758-5	2013	The AHP2 coding sequence was cloned into pRSET B expression vector, enabling production of AHP2 fused to an N-terminal His tag.	Histidine	119-122	histidine-containing phosphotransmitter 2	Arabidopsis thaliana	4-8
23313943-0	2013	Salt bridge in the conserved His-Asp cluster in Gloeobacter rhodopsin contributes to trimer formation.	Histidine	29-32	rhodopsin	Homo sapiens	60-69
23313943-1	2013	Gloeobacter rhodopsin (GR) is a eubacterial proton pump having a highly conserved histidine near the retinal Schiff base counter-ion, aspartate.	Histidine	82-91	rhodopsin	Homo sapiens	12-21
22446793-3	2013	CES2 secretion to the media was achieved by the simple addition of an in-frame C-terminal 10x histidine tag (CES2-10xHis) without the need of addition of extra N-terminal signalling sequences or the mutation or deletion of the C-terminal HTEL motif responsible for retaining the protein in the lumen of endoplasmic reticulum.	Histidine	94-103	carboxylesterase 2	Homo sapiens	109-113
23293326-13	2013	Finally, discovery of this mutation indicates that in humans, the amino acid sequence His(6)Phe(7)Arg(8)Trp(9) is important not only for cAMP activation but also for ACTH binding to MC2R.	Histidine	86-89	proopiomelanocortin	Homo sapiens	166-170
23282130-4	2013	Upon dissociation, Co(III) irreversibly interacts with specific histidine residues of a protein, and consequently alters structure and causes inhibition.	Histidine	64-73	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	19-26
23195954-2	2013	We demonstrate unknown facets of calnuc, which is a serine protease in which Ser-378 of GXSXG motif, Asp-328 of DTG motif, and His-339 form the "catalytic triad," locating the enzyme active site in the C-terminal region.	Histidine	127-130	coagulation factor II, thrombin	Homo sapiens	52-67
23104315-3	2013	The filtering device, obtained by coupling histidine-tagged bovine OBP to a nickel nitrilotriacetic acid (Ni-NTA) agarose resin, was characterized in terms of retention capacity for the herbicides atrazine, simazine, and propazine.	Histidine	43-52	odorant-binding protein	Bos taurus	67-70
24024135-6	2013	The major part of EC-SOD inhibited by the peroxidase reaction was not fragmented but found to encompass oxidations of histidine residues involved in the coordination of copper (His98 and His163).	Histidine	118-127	superoxide dismutase 3	Homo sapiens	18-24
23244738-2	2013	As it was observed for other tachykinins (neurokinin A, neuropeptide gamma and its fragments) containing the same C-terminal sequence His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH(2), also for the fragments of neuropeptide K the additional deprotonation most likely on the serine OH group was observed.	Histidine	134-137	tachykinin precursor 1	Homo sapiens	42-54
23244738-2	2013	As it was observed for other tachykinins (neurokinin A, neuropeptide gamma and its fragments) containing the same C-terminal sequence His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH(2), also for the fragments of neuropeptide K the additional deprotonation most likely on the serine OH group was observed.	Histidine	134-137	tachykinin precursor 1	Homo sapiens	56-74
23244738-2	2013	As it was observed for other tachykinins (neurokinin A, neuropeptide gamma and its fragments) containing the same C-terminal sequence His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH(2), also for the fragments of neuropeptide K the additional deprotonation most likely on the serine OH group was observed.	Histidine	134-137	tachykinin precursor 1	Homo sapiens	207-221
23809442-2	2013	HRG has a multidomain structure consisting of cystatin-like domains 1 and 2, Pro-rich domain 1, His-rich domain, Pro-rich domain 2, and C-terminal domain from its N-terminus.	Histidine	96-99	histidine rich glycoprotein	Gallus gallus	0-3
23022039-2	2013	More than one third of the mammalian PLA(2) enzymes belong to the secreted PLA(2) (sPLA(2)) family, which consists of low molecular mass, Ca(2+)-requiring enzymes with a His-Asp catalytic dyad.	Histidine	170-173	phospholipase A2 group IB	Homo sapiens	37-43
23022039-2	2013	More than one third of the mammalian PLA(2) enzymes belong to the secreted PLA(2) (sPLA(2)) family, which consists of low molecular mass, Ca(2+)-requiring enzymes with a His-Asp catalytic dyad.	Histidine	170-173	phospholipase A2 group IB	Homo sapiens	75-81
24081113-4	2013	METHODS: The plasmid pcDNA3.1/V5-His-HIF-1alpha was stably transfected into human endothelial cells.	Histidine	33-36	hypoxia inducible factor 1 subunit alpha	Homo sapiens	37-47
23157558-7	2013	An E. coli MV1184 strain transformed with pBSK-Stx2(His) overexpressed histidine-tagged Stx2 (Stx2-His) in cells cultured in CAYE broth in the presence of lincomycin.	Histidine	71-80	syntaxin 2	Mus musculus	47-51
23070294-8	2013	These results allow us to rule out lysine as the sixth ligand at pH values close to neutrality and reinforce the role of histidines (preferentially His33 vs. His26) as the main candidate to replace methionine in the non-native cytochrome c.	Histidine	121-131	cytochrome c, somatic	Homo sapiens	227-239
23157558-7	2013	An E. coli MV1184 strain transformed with pBSK-Stx2(His) overexpressed histidine-tagged Stx2 (Stx2-His) in cells cultured in CAYE broth in the presence of lincomycin.	Histidine	71-80	syntaxin 2	Mus musculus	88-92
23157558-7	2013	An E. coli MV1184 strain transformed with pBSK-Stx2(His) overexpressed histidine-tagged Stx2 (Stx2-His) in cells cultured in CAYE broth in the presence of lincomycin.	Histidine	71-80	syntaxin 2	Mus musculus	88-92
23157558-9	2013	From 1 L of culture, 68.8 mg of Stx2-His and 61.1 mg of mStx2-His, which was generated by site-directed mutagenesis, were obtained.	Histidine	37-40	syntaxin 2	Mus musculus	32-36
23098902-5	2013	Recombinant N-terminal His-tagged AGT1 purified from Escherichia coli was characterized with Ser, alanine (Ala) and Asn as amino acid donors and glyoxylate, pyruvate and hydroxypyruvate as organic acid acceptors.	Histidine	23-26	alanine:glyoxylate aminotransferase	Arabidopsis thaliana	34-38
23320078-8	2013	When His-391 in OsCOI2 was substituted with Tyr-391, OsCOI2 interacted with a wider range of JAZ proteins, including OsJAZ1, 2, 5~9 and 11, and complemented coi1-1 mutants at a higher frequency than the other OsCOIs and COI1.	Histidine	5-8	RNI-like superfamily protein	Arabidopsis thaliana	157-163
23527195-4	2013	Sequencing revealed a single novel mutation in LRRC6 (Leucine-rich repeat containing protein 6) that fit the model of autosomal recessive genetic transmission, leading to a change of a highly conserved amino acid from aspartic acid to histidine (Asp146His).	Histidine	235-244	dynein axonemal assembly factor 11	Homo sapiens	47-52
23527195-4	2013	Sequencing revealed a single novel mutation in LRRC6 (Leucine-rich repeat containing protein 6) that fit the model of autosomal recessive genetic transmission, leading to a change of a highly conserved amino acid from aspartic acid to histidine (Asp146His).	Histidine	235-244	dynein axonemal assembly factor 11	Homo sapiens	54-94
23469063-8	2013	Chimeras between NL4-3 and LAI Vif identify the amino acid responsible for the differential degradation activity: A histidine at position 48 in Vif confers activity against A3H-hapII, while an asparagine abolishes its anti-A3H activity.	Histidine	116-125	apolipoprotein B mRNA editing enzyme catalytic subunit 3H	Homo sapiens	173-176
23469063-8	2013	Chimeras between NL4-3 and LAI Vif identify the amino acid responsible for the differential degradation activity: A histidine at position 48 in Vif confers activity against A3H-hapII, while an asparagine abolishes its anti-A3H activity.	Histidine	116-125	apolipoprotein B mRNA editing enzyme catalytic subunit 3H	Homo sapiens	223-226
23424619-3	2013	Cadherin-11 was bound via histidine tag to lipid membranes with chelator head groups.	Histidine	26-35	cadherin 11 L homeolog	Xenopus laevis	0-11
23505486-12	2013	Ferrous iron in the active site of 5-LOX is coordinated by three conserved histidines and the carboxylate of isoleucine(673).	Histidine	75-85	arachidonate 5-lipoxygenase	Homo sapiens	35-40
23320078-8	2013	When His-391 in OsCOI2 was substituted with Tyr-391, OsCOI2 interacted with a wider range of JAZ proteins, including OsJAZ1, 2, 5~9 and 11, and complemented coi1-1 mutants at a higher frequency than the other OsCOIs and COI1.	Histidine	5-8	RNI-like superfamily protein	Arabidopsis thaliana	220-224
22893680-7	2012	Expression of the CaM isoform Gly-Ser-His-CaM (GSH-CaM), which has much higher binding affinity than wild-type CaM for RyR1, restored normal CaM binding to RyR2 in both SR and myocytes of failing hearts.	Histidine	38-41	ryanodine receptor 1	Canis lupus familiaris	119-123
25969756-3	2012	Snail attractant containing bait formulations was prepared from different binary combination (1 : 1 ratio) of carbohydrates (glucose, starch 10 mM) and amino acid (methionine, histidine 10 mM) in 100 ml of 2% agar solution + sublethal (20% and 60% of 24 h and 96 h LC50) doses of different molluscicides (eugenol, ferulic acid, umbelliferone, and limonene).	Histidine	176-185	snail family transcriptional repressor 1	Homo sapiens	0-5
23228830-8	2012	RESULTS: Recombinant proteins and their respective products whose N-terminal his-tag were removed with thrombin were recognized by serum from the patient infected with H. pylori.	Histidine	77-80	coagulation factor II, thrombin	Homo sapiens	103-111
22893680-7	2012	Expression of the CaM isoform Gly-Ser-His-CaM (GSH-CaM), which has much higher binding affinity than wild-type CaM for RyR1, restored normal CaM binding to RyR2 in both SR and myocytes of failing hearts.	Histidine	38-41	ryanodine receptor 2	Canis lupus familiaris	156-160
22555758-6	2012	The prevalence of mEPHX1 exon 3 Tyr/His and His/His was statistically significant (P = 0.004; 0.0001, respectively) when compared with the mEPHX1 exon 3 Tyr/Tyr homozygous carriers in both T2DM patients and in controls.	Histidine	36-39	epoxide hydrolase 1, microsomal	Mus musculus	18-24
22748509-8	2012	Recombinant mature HBD2 with an N-terminal His-tag could be purified by Ni-column chromatography and showed antimicrobial activity against E. coli, Salmonella enterica serovar Typhimurium and Listeria monocytogenes.	Histidine	43-46	defensin beta 4A	Homo sapiens	19-23
23166962-18	2004	(18) identified one 12-mer peptide, Pro-Pro-Trp-Gln-Glu-Trp-His-Asn-Phe-Met-Pro-Phe-NH2 (EGBP), with specific binding activity for human EGFR using phage display screening.	Histidine	60-63	epidermal growth factor receptor	Homo sapiens	137-141
23023396-3	2012	A preferable electron transport pathway for cyt c is through the axial ligand (His-18) of the heme center rather than the porphyrin ring.	Histidine	79-82	cytochrome c, somatic	Homo sapiens	44-49
22773041-3	2012	Herein, we describe a novel mutation in EGFR exon 20 in a female non-smoker bearing a lung adenocarcinoma, characterized by the insertion of a nucleotide triplet GTT, which translates into a protein with an additional Valine between Proline 772 and Histidine 773 (p.P772_H773insV-c.2316_2317insGTT).	Histidine	249-258	epidermal growth factor receptor	Homo sapiens	40-44
22771765-6	2012	We identified the best conditions for injecting the histidine tagged recombinant TSPO in detergent in the subphase and to keep the protein stable.	Histidine	52-61	translocator protein	Mus musculus	81-85
23087673-2	2012	A molecular form known as GnRH2 ([His(5) Trp(7) Tyr(8)]GnRH, also known as chicken GnRH II) is widely distributed in vertebrates except for rodents, and has recently been implicated in the regulation of feeding behavior in goldfish.	Histidine	34-37	mitochondrial ribosomal protein S26	Gallus gallus	83-90
22707198-3	2012	To understand the molecular mechanisms by which cyclo (His-Pro) (CHP) affects amelioration of diabetes mellitus, we performed gene expression profiling in the pancreatic tissues of two diabetic animal models, streptozocin (STZ)-induced diabetic rats (T1DM) and genetically-diabetic (C57BL/6J ob/ob) mice (T2DM).	Histidine	55-58	ras homolog family member V	Rattus norvegicus	65-68
22883960-7	2012	In PCb, the histidine remains covalently bound to Cu(I) and may adopt a doubly protonated state at low pH.	Histidine	12-21	pyruvate carboxylase	Homo sapiens	3-6
22902558-4	2012	Through structure-function analysis, we identify several SID-2 regions required for this activity, including three extracellular, positively charged histidines.	Histidine	149-159	Systemic RNA interference defective protein 2	Caenorhabditis elegans	57-62
22766396-2	2012	Experimental evidence has been provided that a histidine-loop within the nucleotide binding domain of ABC transporter is essential for efficient function of this class of transporter proteins.	Histidine	47-56	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	102-117
22766396-3	2012	Here we report the first patient with a mutation of the putative histidine-loop of a human ABC transporter, the multi drug resistance protein 3 (MDR3).	Histidine	65-74	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	91-106
22695166-5	2012	Indirect evidence for the noncovalent multimerization of scFv was the presence of a major peak of multimerized scFv without a His tag (due to differential cleavage) in the Q-TOF profile, unlike monomeric scFv, which copurified with normally His-tagged scFv and recognized the target antigen.	Histidine	126-129	immunglobulin heavy chain variable region	Homo sapiens	57-61
22542526-5	2012	Here, we present evidence that hydrogen peroxide treatment, which generates free radical species at the SOD1 active site, causes oxidative damage to active-site histidine residues, leading to major structural changes and non-amyloid aggregation similar to that seen in ALS.	Histidine	161-170	superoxide dismutase 1	Homo sapiens	104-108
22793878-0	2012	Cresyl saligenin phosphate, an organophosphorus toxicant, makes covalent adducts with histidine, lysine, and tyrosine residues of human serum albumin.	Histidine	86-95	albumin	Homo sapiens	136-149
22695166-5	2012	Indirect evidence for the noncovalent multimerization of scFv was the presence of a major peak of multimerized scFv without a His tag (due to differential cleavage) in the Q-TOF profile, unlike monomeric scFv, which copurified with normally His-tagged scFv and recognized the target antigen.	Histidine	241-244	immunglobulin heavy chain variable region	Homo sapiens	57-61
22695166-5	2012	Indirect evidence for the noncovalent multimerization of scFv was the presence of a major peak of multimerized scFv without a His tag (due to differential cleavage) in the Q-TOF profile, unlike monomeric scFv, which copurified with normally His-tagged scFv and recognized the target antigen.	Histidine	241-244	immunglobulin heavy chain variable region	Homo sapiens	111-115
22695166-5	2012	Indirect evidence for the noncovalent multimerization of scFv was the presence of a major peak of multimerized scFv without a His tag (due to differential cleavage) in the Q-TOF profile, unlike monomeric scFv, which copurified with normally His-tagged scFv and recognized the target antigen.	Histidine	241-244	immunglobulin heavy chain variable region	Homo sapiens	111-115
22695166-5	2012	Indirect evidence for the noncovalent multimerization of scFv was the presence of a major peak of multimerized scFv without a His tag (due to differential cleavage) in the Q-TOF profile, unlike monomeric scFv, which copurified with normally His-tagged scFv and recognized the target antigen.	Histidine	241-244	immunglobulin heavy chain variable region	Homo sapiens	111-115
22729838-1	2012	Cobalt(III) Schiff base complexes have been used as potent inhibitors of protein function through the coordination to histidine residues essential for activity.	Histidine	118-127	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	7-10
22633260-1	2012	OBJECTIVE: To examine the underlying factors leading to infertility in a male patient from whom phospholipase C zeta H398P (PLCzeta(H398P), histidine &gt; proline) and PLCzeta(H233L) (histidine &gt; leucine) mutations were previously identified.	Histidine	184-193	phospholipase C zeta 1	Homo sapiens	96-116
22498933-3	2012	Herein, we report the crystal structure of DeSI-1, revealing that this enzyme forms a homodimer and that the groove between the two subunits is the active site harboring two absolutely conserved cysteine and histidine residues that form a catalytic dyad.	Histidine	208-217	desumoylating isopeptidase 1	Homo sapiens	43-49
22688511-5	2012	The proteolytic cleavage that releases ephrinA1 occurs at three positions near the C terminus, producing three forms ending in valine-175, histidine-177, or serine-178.	Histidine	139-148	ephrin A1	Homo sapiens	39-47
22609005-4	2012	Thus high SCN(-) levels protect against HOCl- and MPO-mediated damage to methionine, tryptophan, lysine, histidine, and tyrosine residues on proteins.	Histidine	105-114	myeloperoxidase	Homo sapiens	50-53
22679014-5	2012	Site-directed mutagenesis revealed that an N-terminal histidine residue, His-426, known to be involved in 2-aminoethyl diphenylborinate-mediated TRPV3 activation, is critical for sensing intracellular proton levels.	Histidine	54-63	transient receptor potential cation channel subfamily V member 3	Homo sapiens	145-150
22679014-5	2012	Site-directed mutagenesis revealed that an N-terminal histidine residue, His-426, known to be involved in 2-aminoethyl diphenylborinate-mediated TRPV3 activation, is critical for sensing intracellular proton levels.	Histidine	73-76	transient receptor potential cation channel subfamily V member 3	Homo sapiens	145-150
22665479-6	2012	A disease-associated single nucleotide polymorphism near His(1186) and a naturally occurring mRNA splice variant lacking exon 14 differentially affect this autolytic processing and subsequent NLRP1 activity.	Histidine	57-60	NLR family pyrin domain containing 1	Homo sapiens	192-197
22727780-1	2012	Twelve thiorhodamine derivatives have been examined for their ability to stimulate the ATPase activity of purified human P-glycoprotein (P-gp)-His(10), to promote uptake of calcein AM and vinblastine into multidrug-resistant, P-gp-overexpressing MDCKII-MDR1 cells, and for their rates of transport in monolayers of multidrug-resistant, P-gp-overexpressing MDCKII-MDR1 cells.	Histidine	143-146	ATP binding cassette subfamily B member 1	Homo sapiens	121-135
22727780-1	2012	Twelve thiorhodamine derivatives have been examined for their ability to stimulate the ATPase activity of purified human P-glycoprotein (P-gp)-His(10), to promote uptake of calcein AM and vinblastine into multidrug-resistant, P-gp-overexpressing MDCKII-MDR1 cells, and for their rates of transport in monolayers of multidrug-resistant, P-gp-overexpressing MDCKII-MDR1 cells.	Histidine	143-146	ATP binding cassette subfamily B member 1	Homo sapiens	137-141
22532564-4	2012	Anti-UGT-1168 antibody trapped 2B15-His-containing co-immunoprecipitates of PKCalpha in 130-140- and &gt;150-kDa complexes by gradient SDS-PAGE analysis.	Histidine	36-39	protein kinase C alpha	Homo sapiens	76-84
22532564-8	2012	Solubilized 2B15-His-transfected Src-free fibroblasts subjected to in vitro [gamma-(33)P]ATP-dependent phosphorylation by PKCalpha and/or Src, affinity purification, and SDS gel analysis revealed 2-fold more radiolabeling of 55-58-kDa 2B15-His by PKCalpha than by Src; labeling was additive for combined kinases.	Histidine	17-20	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	33-36
22532564-8	2012	Solubilized 2B15-His-transfected Src-free fibroblasts subjected to in vitro [gamma-(33)P]ATP-dependent phosphorylation by PKCalpha and/or Src, affinity purification, and SDS gel analysis revealed 2-fold more radiolabeling of 55-58-kDa 2B15-His by PKCalpha than by Src; labeling was additive for combined kinases.	Histidine	17-20	protein kinase C alpha	Homo sapiens	122-130
22532564-8	2012	Solubilized 2B15-His-transfected Src-free fibroblasts subjected to in vitro [gamma-(33)P]ATP-dependent phosphorylation by PKCalpha and/or Src, affinity purification, and SDS gel analysis revealed 2-fold more radiolabeling of 55-58-kDa 2B15-His by PKCalpha than by Src; labeling was additive for combined kinases.	Histidine	17-20	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	138-141
22532564-8	2012	Solubilized 2B15-His-transfected Src-free fibroblasts subjected to in vitro [gamma-(33)P]ATP-dependent phosphorylation by PKCalpha and/or Src, affinity purification, and SDS gel analysis revealed 2-fold more radiolabeling of 55-58-kDa 2B15-His by PKCalpha than by Src; labeling was additive for combined kinases.	Histidine	17-20	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	138-141
22240897-3	2012	Here, we repot that golgi-specific Asp-His-His-Cys (DHHC) zinc finger protein (GODZ) regulates TRAIL/DR4-mediated apoptosis.	Histidine	39-42	TNF superfamily member 10	Homo sapiens	95-100
22553379-7	2012	In conclusion, the levels of branched-chain, aromatic amino acids and alanine increased and the levels of glutamine and histidine decreased with increasing glycemia, reflecting, at least in part, insulin resistance.	Histidine	120-129	insulin	Homo sapiens	196-203
21895963-6	2012	The molecular interaction of PED/PEA-15 with 67LR was confirmed by pull-down experiments with recombinant His-tagged 37LRP on lysates of PED/PEA-15 transfected HEK-293 cells.	Histidine	106-109	ribosomal protein SA	Homo sapiens	117-122
22523035-6	2012	In vivo, administration of HI-TOPK-032 suppressed tumor growth in a colon cancer xenograft model.	Histidine	27-29	PDZ binding kinase	Homo sapiens	30-34
22591173-2	2012	These peptides, the third zinc finger of Sp1 (Sp1-3), the second zinc finger of myelin transcription factor 1 (MyT1-2), and the second Zn-binding sequence of the DNA-binding domain of glucocorticoid receptor (GR-2), bind Zn(2+) with Cys(2)His(2), Cys(2)HisCys, and Cys(4) coordination, respectively.	Histidine	239-242	nuclear receptor subfamily 3 group C member 1	Homo sapiens	184-207
22731404-4	2012	Also, a histidine at position 12 in the leader sequence of Env has been described as a transmission signature that is selected against during chronic infection.	Histidine	8-17	endogenous retrovirus group W member 1, envelope	Homo sapiens	59-62
22545812-4	2012	Previously, we demonstrated that mutation of the two adjacent histidine residues of Abeta40 (H13,14G) resulted in a significant decrease in its level of binding to PC12 cells and mouse cortical/hippocampal neurons.	Histidine	62-71	histocompatibility 13	Mus musculus	93-96
22484288-7	2012	A synthetic replicate of AamAP1 containing a single substitution (His--&gt;Lys) at position 8, generated a peptide (AamAP-S1) with enhanced antimicrobial potency (3-5 muM) against the three test organisms and within this concentration range, hemolytic effects were negligible.	Histidine	66-69	latexin	Homo sapiens	167-170
22484288-8	2012	In addition, this His--&gt;Lys variant exhibited potent growth inhibitory activity (ID(50) 25-40 mum) against several human cancer cell lines and endothelial cells that was absent in both natural peptides.	Histidine	18-21	latexin	Homo sapiens	97-100
22542587-5	2012	Most of the expressed human ATAD3A-Myc-HIS co-purified with the yeast mitochondrial fraction thus suggesting that targeting to this organelle is preserved in yeast.	Histidine	39-42	ATPase family AAA domain containing 3A	Homo sapiens	28-34
22542587-8	2012	By contrast, urea-denaturated ATAD3A-Myc-HIS bound to agarose-nickel beads and could be renatured and eluted to obtain highly pure ATAD3A-Myc-HIS.	Histidine	41-44	ATPase family AAA domain containing 3A	Homo sapiens	30-36
22542587-8	2012	By contrast, urea-denaturated ATAD3A-Myc-HIS bound to agarose-nickel beads and could be renatured and eluted to obtain highly pure ATAD3A-Myc-HIS.	Histidine	41-44	ATPase family AAA domain containing 3A	Homo sapiens	131-137
22456923-5	2012	METHODS: Recombinant hPLCZ1 was synthesized using the Escherichia coli system, and subjected to immunoblot analysis with anti-PLCZ1 and anti-His tag antibodies.	Histidine	141-144	phospholipase C zeta 1	Homo sapiens	21-27
22456923-5	2012	METHODS: Recombinant hPLCZ1 was synthesized using the Escherichia coli system, and subjected to immunoblot analysis with anti-PLCZ1 and anti-His tag antibodies.	Histidine	141-144	phospholipase C zeta 1	Homo sapiens	22-27
22504626-4	2012	The recombinant His(6) tagged hPGHS-2 was purified using Ni-affinity and anion exchange chromatography, whereas the purification of the C-terminally His(6) tagged hPGHS-2 was more efficient.	Histidine	16-19	prostaglandin-endoperoxide synthase 2	Homo sapiens	30-37
22504626-6	2012	The data obtained indicate that both the N- and C-terminally His(6) tagged hPGHS-2 are functional and the catalytic properties of the recombinant protein and the enzyme produced in other expression systems are comparable.	Histidine	61-64	prostaglandin-endoperoxide synthase 2	Homo sapiens	75-82
22563811-7	2012	A local, less dense negatively charged cluster on the surface of camel chymosin may weaken electrostatic binding to the His-Pro cluster of kappa-CN to simultaneously impart reduced substrate affinity and accelerated enzyme-substrate dissociation as compared to bovine chymosin.	Histidine	120-123	chymosin	Camelus bactrianus	71-79
22545812-5	2012	We now demonstrate that the weakened neuronal binding follows the mutation order of H13G < H14G < H13,14G, which suggests that the primary domain for neuronal binding of Abeta40 involves histidine at position 13.	Histidine	187-196	histocompatibility 13	Mus musculus	84-87
22342562-4	2012	Since many of these HSS Co(II) complexants (particularly lactate, formate and histidine) serve as powerful ()OH scavengers, the results acquired indicate that any of this radical generated from the Co(II) source in such complexes via pseudo-Fenton reactions may be "site-specifically" scavenged.	Histidine	78-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
22451665-3	2012	Utilizing biophysical and biochemical methods, we characterized two independent domains, Ala-35-Lys-124 and His-291-Gly-382, on the TRPM3 N terminus, responsible for interactions with the Ca(2+)-binding proteins calmodulin (CaM) and S100A1.	Histidine	108-111	calmodulin 1	Homo sapiens	212-222
22451665-3	2012	Utilizing biophysical and biochemical methods, we characterized two independent domains, Ala-35-Lys-124 and His-291-Gly-382, on the TRPM3 N terminus, responsible for interactions with the Ca(2+)-binding proteins calmodulin (CaM) and S100A1.	Histidine	108-111	calmodulin 1	Homo sapiens	224-227
22451665-3	2012	Utilizing biophysical and biochemical methods, we characterized two independent domains, Ala-35-Lys-124 and His-291-Gly-382, on the TRPM3 N terminus, responsible for interactions with the Ca(2+)-binding proteins calmodulin (CaM) and S100A1.	Histidine	108-111	S100 calcium binding protein A1	Homo sapiens	233-239
22486179-1	2012	We use a host-guest approach to evaluate the effect of Trp guest residues relative to Ala on the kinetics and thermodynamics of formation of His-heme loops in the denatured state of iso-1-cytochrome c at 1.5, 3.0, and 6.0 M guanidine hydrochloride (GdnHCl).	Histidine	141-144	cytochrome c, somatic	Homo sapiens	188-200
22486179-2	2012	Trp guest residues are inserted into an alanine-rich segment placed after a unique His near the N-terminus of iso-1-cytochrome c.	Histidine	83-86	cytochrome c, somatic	Homo sapiens	116-128
22291440-7	2012	Substitution with alanine of the K(143), T(144), and T(147) residues located in the first transmembrane domain of VPAC1 induced a loss of receptor affinity (IC(50)=1035, 874, and 2070 nM, respectively), and pharmacological studies using VIP2-28 indicated that these three residues play an important role in VPAC1 interaction with the first histidine residue of VIP.	Histidine	340-349	vasoactive intestinal peptide receptor 1	Homo sapiens	114-119
22530913-6	2012	Docking study revealed the important amino acid residues (His 15, Tyr 59, Tyr 151, Gly 121 and Gly 122) in the active site of TNFalpha that are involved in binding of the active ligand.	Histidine	58-61	tumor necrosis factor	Homo sapiens	126-134
22439892-9	2012	Although the pK(a) of the catalytic cysteine in USP1 and USP1/UAF1 was almost identical, the pK(a) of the catalytic histidine in USP1/UAF1 was 0.43 pH unit lower than that in USP1, which facilitates general base catalysis at a neutral pH and contributes to the elevated catalytic efficiency.	Histidine	116-125	WD repeat domain 48	Homo sapiens	134-138
22439136-6	2012	The relative standard deviation for 11 replicate detections of 8 muM histidine was 2.0%.	Histidine	69-78	latexin	Homo sapiens	65-68
22342562-4	2012	Since many of these HSS Co(II) complexants (particularly lactate, formate and histidine) serve as powerful ()OH scavengers, the results acquired indicate that any of this radical generated from the Co(II) source in such complexes via pseudo-Fenton reactions may be "site-specifically" scavenged.	Histidine	78-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	198-204
22922100-8	2012	In addition, we show that deletion of the DDHD domain or introduction of point mutations at the conserved aspartate or histidine residues in the domain abolishes the phospholipase activity of KIAAO725p and PA-PLA1.	Histidine	119-128	DDHD domain containing 1	Homo sapiens	206-213
23961177-9	2012	Moreover, essential amino acids (Val, Phe and His) and the non-essential amino acids (Gly and Ser) content was significantly higher in cow milk beta-casein compared to the beta-casein of all camel milk breeds and the opposite was true for Lys, Thr, Met and Ile.	Histidine	46-49	casein beta	Bos taurus	144-155
22689617-1	2012	Mass spectrometry was used to probe the preferred locations of trans-4-hydroxy-2-nonenal (HNE) addition to the cysteine, histidine, and lysine residues of human serum albumin (HSA).	Histidine	121-130	albumin	Homo sapiens	161-174
22189507-3	2012	Using limited proteolysis and mass spectrometry, two peptide regions, which correspond to Ser(100)-Arg(114) and His(89)-Arg(114) in BID, revealed the specific PS-binding site.	Histidine	112-115	BH3 interacting domain death agonist	Homo sapiens	132-135
22270363-3	2012	In this study, we characterized an atypical Hyp-rich glycoprotein, AGP31 (arabinogalactan protein 31), which displays a multidomain organization unique in Arabidopsis thaliana, consisting of a short arabinogalactan protein (AGP) motif, a His stretch, a Pro-rich domain, and a C-terminal PAC (PRP-AGP containing Cys) domain.	Histidine	238-241	arabinogalactan protein 31	Arabidopsis thaliana	74-100
22270363-3	2012	In this study, we characterized an atypical Hyp-rich glycoprotein, AGP31 (arabinogalactan protein 31), which displays a multidomain organization unique in Arabidopsis thaliana, consisting of a short arabinogalactan protein (AGP) motif, a His stretch, a Pro-rich domain, and a C-terminal PAC (PRP-AGP containing Cys) domain.	Histidine	238-241	arabinogalactan protein 31	Arabidopsis thaliana	67-72
22670529-5	2012	It was shown that relative position of Met- and His-rich copper-binding motifs in CTR1 predisposes the extracellular CTR1 part to binding of copper, silver and cisplatin.	Histidine	48-51	solute carrier family 31, member 1	Mus musculus	82-86
22243797-3	2012	In this study, two CdSe/ZnSe QDs modified with beta-CD coupled to L-Arg or L-His were used to simultaneously deliver doxorubicin (Dox) and siRNA targeting the MDR1 gene to reverse the multidrug resistance of HeLa cells.	Histidine	75-80	ATP binding cassette subfamily B member 1	Homo sapiens	159-163
22185821-0	2012	Cyclo(His-Pro) exerts anti-inflammatory effects by modulating NF-kappaB and Nrf2 signalling.	Histidine	6-9	NFE2 like bZIP transcription factor 2	Rattus norvegicus	76-80
22185821-2	2012	Given the existence of a tight interplay of the Nrf2/NF-kappaB systems and that the pro-inflammatory response is governed by transcription factor NF-kappaB, here we sought to investigate whether and how cyclo(His-Pro) interferes with the cross-talk between the antioxidant Nrf2/heme oxygenase-1 and the pro-inflammatory NF-kappaB pathways.	Histidine	209-212	NFE2 like bZIP transcription factor 2	Rattus norvegicus	273-277
22185821-3	2012	By knocking down the Nrf2 gene, we confirmed that cyclo(His-Pro) inhibits NF-kappaB nuclear accumulation induced by paraquat in rat pheochromocytoma PC12 cells via the Nrf2/heme oxygenase-1 pathway.	Histidine	56-59	NFE2 like bZIP transcription factor 2	Rattus norvegicus	21-25
22185821-3	2012	By knocking down the Nrf2 gene, we confirmed that cyclo(His-Pro) inhibits NF-kappaB nuclear accumulation induced by paraquat in rat pheochromocytoma PC12 cells via the Nrf2/heme oxygenase-1 pathway.	Histidine	56-59	NFE2 like bZIP transcription factor 2	Rattus norvegicus	168-172
22420928-2	2012	We have recently focused on using the native CXXCH peptide sequence of the C-terminal segment of cytochrome c(556) as a platform which holds a diiron carbonyl cluster via two cysteines and have attached a ruthenium photosensitizer via a histidine.	Histidine	237-246	cytochrome c, somatic	Homo sapiens	97-109
22670529-5	2012	It was shown that relative position of Met- and His-rich copper-binding motifs in CTR1 predisposes the extracellular CTR1 part to binding of copper, silver and cisplatin.	Histidine	48-51	solute carrier family 31, member 1	Mus musculus	117-121
22070190-4	2012	However, in the Arabidopsis thaliana stomatal K(in) channel KAT1, mutations in the unique histidine exposed to the solvent (His267) do not affect the pH dependency.	Histidine	90-99	1	Arabidopsis thaliana	60-64
22077443-9	2012	Finally, we showed that the HNE-histidine adduct stimulated the formation of reactive oxygen species and activated extracellular-signal-regulated kinase 1/2 and NF-kappaB (nuclear factor kappaB) in HAECs (human aortic endothelial cells); these signals initiate endothelial dysfunction and lead to atherosclerosis.	Histidine	32-41	mitogen-activated protein kinase 3	Homo sapiens	115-156
22243664-7	2012	The site of PEGylation at the His-tag for both dAb-His(6)-PEG and PEG-His(8)-IFN was confirmed by digestion, chromatographic, and mass-spectral studies.	Histidine	30-33	interferon alpha 1	Homo sapiens	77-80
22243664-6	2012	His-tag site-specific PEGylation was achieved with a domain antibody (dAb) that had a 6-histidine His-tag on the C-terminus (dAb-His(6)) and interferon alpha-2a (IFN) that had an 8-histidine His-tag on the N-terminus (His(8)-IFN).	Histidine	0-3	interferon alpha 1	Homo sapiens	162-165
22243664-6	2012	His-tag site-specific PEGylation was achieved with a domain antibody (dAb) that had a 6-histidine His-tag on the C-terminus (dAb-His(6)) and interferon alpha-2a (IFN) that had an 8-histidine His-tag on the N-terminus (His(8)-IFN).	Histidine	0-3	interferon alpha 1	Homo sapiens	225-228
22178916-0	2012	Microplate assay for aptamer-based thrombin detection using a DNA-enzyme conjugate based on histidine-tag chemistry.	Histidine	92-101	coagulation factor II, thrombin	Homo sapiens	35-43
22243664-8	2012	A methionine was also inserted directly after the N-terminal His-tag in IFN to give His(8)Met-IFN.	Histidine	61-64	interferon alpha 1	Homo sapiens	72-75
22243664-8	2012	A methionine was also inserted directly after the N-terminal His-tag in IFN to give His(8)Met-IFN.	Histidine	61-64	interferon alpha 1	Homo sapiens	94-97
22243664-9	2012	Cyanogen bromide digestion studies of PEG-His(8)Met-IFN were also consistent with PEGylation at the His-tag.	Histidine	42-45	interferon alpha 1	Homo sapiens	52-55
22243664-10	2012	By using increased stoichiometries of the PEGylation reagent, it was possible to conjugate two separate PEG molecules to the His-tag of both the dAb and IFN proteins.	Histidine	125-128	interferon alpha 1	Homo sapiens	153-156
22174408-3	2012	We exploit a heme synthesis-defective Saccharomyces cerevisiae mutant to model the heme auxotrophy of C. elegans and demonstrate that, under heme-deplete conditions, the endosomal CeHRG-1 requires both a specific histidine in the predicted second transmembrane domain (TMD2) and the FARKY motif in the C terminus tail for heme transport.	Histidine	213-222	Heme transporter hrg-1	Caenorhabditis elegans	180-187
22174408-5	2012	Optimal activity under heme-limiting conditions, however, requires histidine in the E2 loop of CeHRG-1 and tyrosine in TMD2 of CeHRG-4.	Histidine	67-76	Heme transporter hrg-1	Caenorhabditis elegans	95-102
22174408-6	2012	An analogous system exists in humans, because mutation of the synonymous histidine in TMD2 of hHRG-1 eliminates heme transport activity, implying an evolutionary conserved heme transport mechanism that predates vertebrate origins.	Histidine	73-82	TropoMoDulin	Caenorhabditis elegans	86-90
22236003-6	2012	Cysteine, histidine and glycine significantly reduced NF-kappaB activation and inhibitor kappaBalpha (IkappaBalpha) degradation in HCAECs stimulated with TNF-alpha.	Histidine	10-19	nuclear factor kappa B subunit 1	Homo sapiens	54-63
22302847-0	2012	False-negative rapid diagnostic tests for malaria and deletion of the histidine-rich repeat region of the hrp2 gene.	Histidine	70-79	HDGF like 2	Homo sapiens	106-110
22236003-6	2012	Cysteine, histidine and glycine significantly reduced NF-kappaB activation and inhibitor kappaBalpha (IkappaBalpha) degradation in HCAECs stimulated with TNF-alpha.	Histidine	10-19	NFKB inhibitor alpha	Homo sapiens	102-114
22236003-6	2012	Cysteine, histidine and glycine significantly reduced NF-kappaB activation and inhibitor kappaBalpha (IkappaBalpha) degradation in HCAECs stimulated with TNF-alpha.	Histidine	10-19	tumor necrosis factor	Homo sapiens	154-163
22236003-8	2012	Our results show that glycine, histidine and cysteine can inhibit NF-kappaB activation, IkappaBalpha degradation, CD62E expression and IL-6 production in HCAECs, suggesting that these amino acids may exhibit anti-inflammatory effects during endothelial inflammation.	Histidine	31-40	nuclear factor kappa B subunit 1	Homo sapiens	66-75
22236003-8	2012	Our results show that glycine, histidine and cysteine can inhibit NF-kappaB activation, IkappaBalpha degradation, CD62E expression and IL-6 production in HCAECs, suggesting that these amino acids may exhibit anti-inflammatory effects during endothelial inflammation.	Histidine	31-40	NFKB inhibitor alpha	Homo sapiens	88-100
22236003-8	2012	Our results show that glycine, histidine and cysteine can inhibit NF-kappaB activation, IkappaBalpha degradation, CD62E expression and IL-6 production in HCAECs, suggesting that these amino acids may exhibit anti-inflammatory effects during endothelial inflammation.	Histidine	31-40	interleukin 6	Homo sapiens	135-139
22155078-1	2012	Tyrosyl-DNA phosphodiesterase I (Tdp1) is a member of the phospholipase D superfamily that hydrolyzes 3"-phospho-DNA adducts via two conserved catalytic histidines-one acting as the lead nucleophile and the second acting as a general acid/base.	Histidine	153-163	tyrosyl-DNA phosphodiesterase 1	Saccharomyces cerevisiae S288C	33-37
22172969-4	2012	This virus displays simultaneously histidine-tagged GP5 and Cap proteins with the baculovirus glycoprotein gp64 TM and CTD on the virion surface as well as the surface of the virus-infected cells.	Histidine	35-44	glycoprotein V platelet	Homo sapiens	52-55
22155078-4	2012	The structures of wild-type Tdp1 and His432Arg both show a phosphorylated form of the nucleophilic histidine that is not observed in the structure of His432Asn.	Histidine	99-108	tyrosyl-DNA phosphodiesterase 1	Saccharomyces cerevisiae S288C	28-32
23140162-9	2012	As a shuttling Cys(2)His(2) zinc finger protein, Nmp4/CIZ acts as a repressive transcription factor perhaps associated with epigenetic remodeling complexes, but the functional significance of its interaction with p130Cas is not known.	Histidine	21-24	zinc finger protein 384	Mus musculus	49-53
22215085-5	2012	These networks involve conserved histidines in both FcRn and albumin domain III.	Histidine	33-43	Fc gamma receptor and transporter	Homo sapiens	52-56
22293477-3	2012	In this study, we have constructed a prediction scheme with target-specific scores for estimating ligand-binding affinities to human estrogen receptor alpha (ERalpha), considering the major conformational change between agonist- and antagonist-bound forms and the change in protonation states of histidine at the ligand-binding site.	Histidine	296-305	estrogen receptor 1	Homo sapiens	133-156
22293477-3	2012	In this study, we have constructed a prediction scheme with target-specific scores for estimating ligand-binding affinities to human estrogen receptor alpha (ERalpha), considering the major conformational change between agonist- and antagonist-bound forms and the change in protonation states of histidine at the ligand-binding site.	Histidine	296-305	estrogen receptor 1	Homo sapiens	158-165
23140162-9	2012	As a shuttling Cys(2)His(2) zinc finger protein, Nmp4/CIZ acts as a repressive transcription factor perhaps associated with epigenetic remodeling complexes, but the functional significance of its interaction with p130Cas is not known.	Histidine	21-24	zinc finger protein 384	Mus musculus	54-57
22558227-4	2012	Because the D7H mutant Abeta has an additional metal ion-coordinating residue, histidine, we speculate that this mutation may promote susceptibility of Abeta to ion.	Histidine	79-88	amyloid beta precursor protein	Homo sapiens	23-28
22807623-4	2012	In addition, the histidine (His) amino acid is found in both domains of the double domain AP2 protein, which is missing in single domain ERF proteins.	Histidine	17-26	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	90-93
22807623-4	2012	In addition, the histidine (His) amino acid is found in both domains of the double domain AP2 protein, which is missing in single domain ERF proteins.	Histidine	28-31	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	90-93
22178692-4	2012	We report a novel method for the use of strains of the fruit fly Drosophila melanogaster genetically engineered to produce histidine-tagged recombinant muscle myosin isoforms.	Histidine	123-132	Myosin heavy chain	Drosophila melanogaster	159-165
22178692-6	2012	We illustrate this method by expressing and purifying a recombinant histidine-tagged variant of embryonic body wall skeletal muscle myosin II from an engineered fly strain.	Histidine	68-77	Myosin heavy chain	Drosophila melanogaster	125-141
21842374-5	2012	Mutation to the N-domain histidine and N-domain cysteines resulted in increased binding of ERp57.	Histidine	25-34	protein disulfide isomerase family A member 3	Homo sapiens	91-96
22642361-4	2012	Recently, we developed a specific and potent hCD59 inhibitor, His-tagged ILYd4, which consists of 30 amino acid sequences extending from the N-terminus of ILYd4.	Histidine	62-65	CD59 molecule (CD59 blood group)	Homo sapiens	45-50
22123124-0	2012	Effect of histidine-tag and R457H and E580Q mutations on catalytic activity of recombinant human cytochrome P450 oxidoreductase.	Histidine	10-19	cytochrome p450 oxidoreductase	Homo sapiens	97-127
22123124-3	2012	In this study, Vmax, Km, and Vmax/Km values of cytochrome c reduction and NADPH oxidation activities for R457H variant, histidine-tagged wild-type, and histidine-tagged E580Q were compared with those for wild-type.	Histidine	120-129	cytochrome c, somatic	Homo sapiens	47-59
22123124-3	2012	In this study, Vmax, Km, and Vmax/Km values of cytochrome c reduction and NADPH oxidation activities for R457H variant, histidine-tagged wild-type, and histidine-tagged E580Q were compared with those for wild-type.	Histidine	152-161	cytochrome c, somatic	Homo sapiens	47-59
22123124-4	2012	Vmax/Km values of cytochrome c reduction for the R457H variant and histidine-tagged wild-type were 8% and 26%, respectively, of wild-type, whereas Vmax/Km values of NADPH oxidation for the R457H variant and histidine-tagged wild-type were similar to those for wild-type.	Histidine	67-76	cytochrome c, somatic	Homo sapiens	18-30
22123124-4	2012	Vmax/Km values of cytochrome c reduction for the R457H variant and histidine-tagged wild-type were 8% and 26%, respectively, of wild-type, whereas Vmax/Km values of NADPH oxidation for the R457H variant and histidine-tagged wild-type were similar to those for wild-type.	Histidine	207-216	cytochrome c, somatic	Homo sapiens	18-30
22719904-4	2012	A series of full-length His-tagged GFP-RyR1 fusion constructs were created, expressed in human embryonic kidney (HEK)-293T cells and then complexed with Cy3NTA, a His-tag specific FRET acceptor.	Histidine	24-27	ryanodine receptor 1	Homo sapiens	39-43
22558227-4	2012	Because the D7H mutant Abeta has an additional metal ion-coordinating residue, histidine, we speculate that this mutation may promote susceptibility of Abeta to ion.	Histidine	79-88	amyloid beta precursor protein	Homo sapiens	152-157
22199132-4	2011	The k(cat)/K(m) values of Nma-Phe-His-Lys(Dnp), Nma-His-Pro-Phe-Lys(Dnp)-Pro, and Hip-His-Leu were 5.12, 1.90, and 0.80 microM(-1) s(-1) for rabbit lung ACE, and 16.0, 7.36, and 0.30 microM(-1) s(-1) for recombinant human (rh)-ACE, respectively.	Histidine	34-37	angiotensin I converting enzyme	Homo sapiens	227-230
22641195-9	2011	Novel strategies have recently been proposed based on subcutaneous supramolecular assembly coupled to (a) large-scale allosteric reorganization of the insulin hexamer (the TR transition), (b) pH-dependent binding of zinc ions to engineered His-X(3)-His sites at hexamer surfaces, or (c) the long-range vision of glucose-responsive polymers for regulated hormone release.	Histidine	240-243	insulin	Homo sapiens	151-158
23082100-7	2012	Sonodynamically induced apoptosis, caspase-3 activation, and nitroxide generation were significantly suppressed by histidine.	Histidine	115-124	caspase 3	Homo sapiens	35-44
23082100-9	2012	The significant reduction in sonodynamically induced apoptosis, nitroxide generation, and caspase-3 activation by histidine suggests active species such as singlet oxygen are important in the sonodynamic induction of apoptosis.	Histidine	114-123	caspase 3	Homo sapiens	90-99
22032417-2	2011	CaM contains 9 methionine (Met), 1 histidine (His), 17 aspartic acid (Asp), and 23 glutamine acid (Glu) residues, all of which can potentially react with platinum compounds; thus, one-third of the CaM sequence is a possible binding target of platinum anticancer drugs, which represents a major challenge for identification of specific platinum modification sites.	Histidine	35-44	calmodulin 1	Homo sapiens	0-3
22032417-2	2011	CaM contains 9 methionine (Met), 1 histidine (His), 17 aspartic acid (Asp), and 23 glutamine acid (Glu) residues, all of which can potentially react with platinum compounds; thus, one-third of the CaM sequence is a possible binding target of platinum anticancer drugs, which represents a major challenge for identification of specific platinum modification sites.	Histidine	46-49	calmodulin 1	Homo sapiens	0-3
21956104-1	2011	In the Saccharomyces cerevisiae actin-profilin interface, Ala(167) of the actin barbed end W-loop and His(372) near the C terminus form a clamp around a profilin segment containing residue Arg(81) and Tyr(79).	Histidine	102-105	actin	Saccharomyces cerevisiae S288C	32-37
21967851-0	2011	Manipulating the proximal triad His-Asn-Arg in human myeloperoxidase.	Histidine	32-35	myeloperoxidase	Homo sapiens	53-68
22199132-8	2011	The newly developed IQF substrate, Nma-Phe-His-Lys(Dnp), is a valuable tool for ACE and carboxypeptidase studies.	Histidine	43-46	angiotensin I converting enzyme	Homo sapiens	80-83
22082027-7	2011	RESULTS: The rS100A7 (His-tag) protein was homogeneous by SDS-PAGE and mass spectrometry and was used to produce an anti-recombinant S100A7 (His-tag) rabbit serum (polyclonal antibody anti-rS100A7).	Histidine	22-25	S100 calcium binding protein A7	Homo sapiens	14-20
22010849-1	2011	Spherical silica nanoparticles (SNP) have been synthesized and functionalized with anti-HER-2 scFv800E6 antibody by both localized histidine-tag recognition, leading to an oriented protein ligation, and glutaraldehyde cross-linking, exploiting a statistical reactivity of lysine amine groups in the primary sequence of the molecule.	Histidine	131-140	erb-b2 receptor tyrosine kinase 2	Homo sapiens	88-93
21939770-8	2011	Hypothetical MARCH5 proteins from trout comprise four transmembrane helices and a single motif similar to a RING variant domain (RINGv) including eight highly conserved cysteine and histidine residues.	Histidine	182-191	E3 ubiquitin-protein ligase MARCH5	Oncorhynchus mykiss	13-19
22010140-3	2011	Molecular analysis of the PLCzeta gene of a male patient with oocyte activation deficiency has previously identified a point mutation causing a histidine to proline substitution at PLCzeta residue 398 (PLCzeta(H398P)), leading to abnormal Ca(2+) release profiles and reduced oocyte activation efficiency.	Histidine	144-153	phospholipase C zeta 1	Homo sapiens	26-33
22010140-3	2011	Molecular analysis of the PLCzeta gene of a male patient with oocyte activation deficiency has previously identified a point mutation causing a histidine to proline substitution at PLCzeta residue 398 (PLCzeta(H398P)), leading to abnormal Ca(2+) release profiles and reduced oocyte activation efficiency.	Histidine	144-153	phospholipase C zeta 1	Homo sapiens	181-188
22010140-3	2011	Molecular analysis of the PLCzeta gene of a male patient with oocyte activation deficiency has previously identified a point mutation causing a histidine to proline substitution at PLCzeta residue 398 (PLCzeta(H398P)), leading to abnormal Ca(2+) release profiles and reduced oocyte activation efficiency.	Histidine	144-153	phospholipase C zeta 1	Homo sapiens	181-188
21648440-1	2011	The MP2/6-31G*(0.25) pi-pi or pi(+)-pi T-shaped (edge-to-face) interactions between neutral or protonated histidine and adenine were considered using computational models of varying size to determine the effects of the protein and DNA backbones on the preferred dimer structure and binding strength.	Histidine	106-115	major intrinsic protein of lens fiber	Homo sapiens	4-9
21785859-5	2011	RESULTS: Cysteine, histidine and glycine significantly reduced the activation of NF-kappaB in THP-1 cells stimulated with TNF-alpha.	Histidine	19-28	nuclear factor kappa B subunit 1	Homo sapiens	81-90
22102235-4	2011	This study reports the cloning, expression in Escherichia coli, purification, crystallization and preliminary X-ray analysis of the C2A domain of human synaptotagmin 5 with an N-terminal His(6) tag.	Histidine	187-190	synaptotagmin 5	Homo sapiens	152-167
22102247-4	2011	In this study, human NALP3 PYD, corresponding to amino acids 3-110, was overexpressed in Escherichia coli using engineered C-terminal His tags.	Histidine	134-137	NLR family pyrin domain containing 3	Homo sapiens	21-26
21894976-2	2011	Tryptic digestion of bovine serum albumin (BSA) performed in histidine buffered solutions yields similar amino acid sequence coverage values to those obtained using ammonium bicarbonate buffer.	Histidine	61-70	albumin	Homo sapiens	28-41
21785859-5	2011	RESULTS: Cysteine, histidine and glycine significantly reduced the activation of NF-kappaB in THP-1 cells stimulated with TNF-alpha.	Histidine	19-28	tumor necrosis factor	Homo sapiens	122-131
21785859-6	2011	In addition, cysteine and histidine significantly inhibited the expression of ICAM-1 and production of IL-8 in THP-1 cells and PBMCs.	Histidine	26-35	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
21909526-1	2011	Unfolding turns immobilized cytochrome c into a His-His ligated form endowed with catalytic activity towards O(2), which is absent in the native protein.	Histidine	48-51	cytochrome c, somatic	Homo sapiens	28-40
21839088-9	2011	Histidine prevented the restoration of eNOS activity by the dipeptide, suggesting that a transporter accepting both, peptides and histidine, mediates the uptake of the extracellular peptide.	Histidine	0-9	nitric oxide synthase 3	Homo sapiens	39-43
21839088-9	2011	Histidine prevented the restoration of eNOS activity by the dipeptide, suggesting that a transporter accepting both, peptides and histidine, mediates the uptake of the extracellular peptide.	Histidine	130-139	nitric oxide synthase 3	Homo sapiens	39-43
21927765-0	2011	Immobilised vitamin B12 as a biomimetic model for base-off/histidine-on coordination.	Histidine	59-68	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	20-23
21927765-1	2011	Immobilisation of vitamin B12 allows synthesising a biomimetic base-off/histidine-on complex that resembles structural features of cobalamin dependent enzyme active sites.	Histidine	72-81	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	26-29
21849510-6	2011	The same approach shows that Ale1p and Are2p also have the uniquely conserved histidine residing in the ER lumen.	Histidine	78-87	lysophospholipid acyltransferase	Saccharomyces cerevisiae S288C	29-34
21909526-1	2011	Unfolding turns immobilized cytochrome c into a His-His ligated form endowed with catalytic activity towards O(2), which is absent in the native protein.	Histidine	52-55	cytochrome c, somatic	Homo sapiens	28-40
21899370-1	2011	The endocannabinoid hydrolyzing enzyme FAAH uses a nonclassical catalytic triad (namely, Ser-Ser-Lys instead of Ser-Asp-His) to cleave its endogenous substrates.	Histidine	120-123	fatty acid amide hydrolase	Homo sapiens	39-43
21708292-7	2011	There was a single Histidine to Asparagine substitution in the 131st position which is a part of 120 loop on HA1 region along with a deletion at position 178 in the Kolkata strains belonging to the Yamagata lineage.	Histidine	19-28	Rho GTPase activating protein 45	Homo sapiens	109-112
21866897-3	2011	Surprisingly, in the heme protein nitrophorin 7 (NP7), we noticed by UV-vis absorbance spectroscopy and resonance Raman spectroscopy that heme reduction leads to a loss of the proximal histidine coordination, which is not observed for the other isoproteins (NP1-4).	Histidine	185-194	neuronal pentraxin 1	Homo sapiens	258-263
21616146-3	2011	Here we used the yeast two-hybrid system to demonstrate that FGFRL1 binds with its C-terminal, histidine-rich domain to Spred1 and to other proteins of the Sprouty/Spred family.	Histidine	95-104	fibroblast growth factor receptor like 1	Homo sapiens	61-67
21720098-3	2011	In this study, HismFGF4, a 6x histidine-tagged mouse FGF4, was produced in E. coli and purified using heparin column chromatography.	Histidine	30-39	fibroblast growth factor 4	Mus musculus	19-23
21893199-5	2011	This ataxin-1 protein was expressed in Escherichia coli as a fusion protein with a GST tag at the N-terminus and a double (His)(6) tag at the C-terminus.	Histidine	123-126	ataxin 1	Homo sapiens	5-13
21893202-6	2011	Analysis of mixed TNF trimers, prepared from tag-free TNF doped with various amounts of histidine-tagged TNF, revealed an increased retention of the trimeric protein on immobilized metal-ion affinity chromatography (IMAC) columns.	Histidine	88-97	tumor necrosis factor	Homo sapiens	18-21
21893202-7	2011	When 20% of histidine-tagged TNF was added, more than 50% of the protein was retained on the IMAC column.	Histidine	12-21	tumor necrosis factor	Homo sapiens	29-32
21893202-9	2011	Various histidine-tags were fused to the N-terminus of full-length TNF-alpha and to the truncated form (dN6) of TNF-alpha.	Histidine	8-17	tumor necrosis factor	Homo sapiens	67-76
21893202-9	2011	Various histidine-tags were fused to the N-terminus of full-length TNF-alpha and to the truncated form (dN6) of TNF-alpha.	Histidine	8-17	tumor necrosis factor	Homo sapiens	112-121
21505802-3	2011	The vector contained the sequence encoding the human FGF21 gene fused with green florescence protein and a histidine tag.	Histidine	107-116	fibroblast growth factor 21	Homo sapiens	53-58
21628446-4	2011	Chromatographic purification and structural analysis by matrix-assisted laser desorption/ionization time-of-flight/time-of-flight (MALDI-TOF/TOF) revealed an Ang II-like octapeptide, angioprotectin, with the sequence Pro-Glu-Val-Tyr-Ile-His-Pro-Phe, which differs from Ang II in Pro1 and Glu2 instead of Asp1 and Arg2.	Histidine	237-240	angiotensinogen	Homo sapiens	158-164
21628446-5	2011	Pro-Glu-Val-Tyr-Ile-His-Pro-Phe in angioprotectin is most likely generated enzymatically from Ang II.	Histidine	20-23	angiotensinogen	Homo sapiens	94-100
21882401-0	2004	3-Cyano-4-[(18)F]fluoro-benzoyl-Ala(SO3H)-Ala(SO3H)-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2 The amphibian bombesin (BBN or BN, a peptide of 14 amino acids) is an analog of human gastrin-releasing peptide (GRP, a peptide of 27 amino acids), which binds to the GRP receptor (GRPR) with high affinity and specificity (1).	Histidine	79-82	gastrin releasing peptide receptor	Homo sapiens	276-280
21491887-2	2011	At physiological pH, the Cu(II) coordination in Abeta is heterogeneous, and there exist at least two binding modes in which Cu(II) is coordinated by histidine residues.	Histidine	149-158	amyloid beta precursor protein	Homo sapiens	48-53
21741339-2	2011	Histatin-5 (Hst-5, DSHAKRHHGYKRKFHEKHHSHRGY), a prominent member of this family contains an albumin-like, N-terminal Asp-Ser-His sequence, known to bind a Ni(II) ion in a square-planar geometry.	Histidine	0-3	histatin 3	Homo sapiens	12-17
21696155-6	2011	Phosphorylation of the full-length protein, His-tagged pro-caspase-3, was demonstrated through Fc-phosphoamide transfer to the Ser residues of the surface-bound protein by electrochemical means.	Histidine	44-47	caspase 3	Homo sapiens	55-68
21666675-2	2011	Most missense mutations in the OCRL ASH-RhoGAP domain that are found in affected individuals abolish interactions with the endocytic adaptors APPL1 and Ses (both Ses1 and Ses2), which bind OCRL through a short phenylalanine and histidine (F&amp;H) motif.	Histidine	228-237	secernin 1	Homo sapiens	162-166
21679093-5	2011	A highly positively charged substrate, Ac-Val-Arg-Leu-Lys-His-Arg-Lys-Leu-Arg-pNA, containing the peptide surrounding the phosphorylated histidine in ion channel KCa3.1 was chemically phosphorylated using phosphoramidate.	Histidine	58-61	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4	Mus musculus	162-168
21679093-5	2011	A highly positively charged substrate, Ac-Val-Arg-Leu-Lys-His-Arg-Lys-Leu-Arg-pNA, containing the peptide surrounding the phosphorylated histidine in ion channel KCa3.1 was chemically phosphorylated using phosphoramidate.	Histidine	137-146	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4	Mus musculus	162-168
21606109-7	2011	Histidine modification of Cx45 protein by N-bromosuccinimide reduced the coupling-promoting effect of NH4Cl as well as the uncoupling effect of octanol.	Histidine	0-9	gap junction protein gamma 1	Homo sapiens	26-30
21606109-8	2011	This suggests that LCCAs and some other uncouplers may act through the formation of hydrogen bonds with the as-of-yet unidentified histidine/s of the Cx45 GJ channel protein.	Histidine	131-140	gap junction protein gamma 1	Homo sapiens	150-154
21733186-9	2011	CONCLUSIONS: Universal conservation of a set of histidine and aspartate residues across all groups in the CREST superfamily, coupled with independent discoveries of hydrolase activities in alkaline ceramidases and the Per1 family as well as results from previous mutational studies of Per1, suggests that the majority of CREST members are metal-dependent hydrolases.	Histidine	48-57	SS18L1 subunit of BAF chromatin remodeling complex	Homo sapiens	106-111
21592973-0	2011	Phylogenetic and functional analysis of histidine residues essential for pH-dependent multimerization of von Willebrand factor.	Histidine	40-49	von Willebrand factor	Homo sapiens	105-126
21592973-3	2011	VWF multimer assembly occurs in the trans-Golgi at pH ~ 6.2 but not at pH 7.4, which suggests that protonation of one or more His residues (pK(a) ~6.0) mediates the pH dependence of multimerization.	Histidine	126-129	von Willebrand factor	Homo sapiens	0-3
21592973-7	2011	These results suggest that pH sensing by evolutionarily conserved His residues facilitates the assembly and packaging of VWF multimers upon arrival in the trans-Golgi.	Histidine	66-69	von Willebrand factor	Homo sapiens	121-124
21639129-6	2011	Furthermore, complex [Ir(ppy)(2)(PBT)] has been further developed as an AND and INHIBIT logic gate with Hg(2+) and histidine as inputs.	Histidine	115-124	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	33-36
21550982-5	2011	MALDI-TOF-MS analysis of peptides harboring site-directed substitutions of cysteine with histidine residues within the PARP-1 zinc finger revealed that arsenite bound to peptides containing three or four cysteine residues, but not to peptides with two cysteines, demonstrating arsenite binding selectivity.	Histidine	89-98	poly(ADP-ribose) polymerase 1	Homo sapiens	119-125
20842634-12	2011	The mode of his-tag binding by C706 resembles the Abeta recognition by antibodies PFA1 and WO2.	Histidine	12-15	amyloid beta precursor protein	Homo sapiens	50-55
20842634-14	2011	By similarity, residues Phe-Arg-His of Abeta would be a major portion of the C706 epitope.	Histidine	32-35	amyloid beta precursor protein	Homo sapiens	39-44
21398639-7	2011	Placing the SAE3 and PCH2 introns within a HIS3 reporter confers Tgs1-dependent histidine prototrophy, signifying that the respective introns are portable determinants of TMG-dependent gene expression.	Histidine	80-89	Pch2p	Saccharomyces cerevisiae S288C	21-25
21398639-7	2011	Placing the SAE3 and PCH2 introns within a HIS3 reporter confers Tgs1-dependent histidine prototrophy, signifying that the respective introns are portable determinants of TMG-dependent gene expression.	Histidine	80-89	RNA methyltransferase	Saccharomyces cerevisiae S288C	65-69
21476495-1	2011	Macrocyclic analogues of angiotensin IV (Ang IV, Val(1)-Tyr(2)-Ile(3)-His(4)-Pro(5)-Phe(6)) targeting the insulin-regulated aminopeptidase (IRAP) have been designed, synthesized, and evaluated biologically.	Histidine	70-73	leucyl and cystinyl aminopeptidase	Homo sapiens	106-138
21506533-1	2011	The extracellular signal-regulated protein kinase, ERK2, fully activated by phosphorylation and without a His(6) tag, shows little tendency to dimerize with or without either calcium or magnesium ions when analyzed by light scattering or analytical ultracentrifugation.	Histidine	106-109	mitogen-activated protein kinase 1	Homo sapiens	51-55
20499205-4	2011	The distribution of Cd (II) and Pb (II) in alanine (Ala), aspartic acid (Asp), glutamic acid (Glu), glycine (Gly), histidine (His), methionine (Met), phenylalanine (Phe), serine (Ser), and threonine (Thr) were analyzed by monitoring changes in the concentration of free amino acids by HPLC/IC.	Histidine	115-124	submaxillary gland androgen regulated protein 3B	Homo sapiens	20-39
21506533-14	2011	Analysis of the same ERK2 construct with the nonphysiological His(6) tag shows substantial dimerization under the same ionic conditions.	Histidine	62-65	mitogen-activated protein kinase 1	Homo sapiens	21-25
21530495-0	2011	A conserved histidine in human DNLZ/HEP is required for stimulation of HSPA9 ATPase activity.	Histidine	12-21	heat shock protein family A (Hsp70) member 9	Homo sapiens	71-76
22096847-8	2011	RTL (0.90 +/- 0.58) of individuals with the Tyr/His genotype at mEH Tyr113His was significantly shorter than that (1.24 +/- 0.90) of individuals with the Tyr/Tyr genotype (P &lt; 0.05).	Histidine	48-51	epoxide hydrolase 1, microsomal	Mus musculus	64-67
21554858-4	2011	The rVP1, rVP2, and rVP3 expressed in Sf9 cells were detected by anti-GPV sera, anti-VP3 sera, and anti-His antibodies, respectively.	Histidine	104-107	claudin 3	Rattus norvegicus	4-8
21554858-4	2011	The rVP1, rVP2, and rVP3 expressed in Sf9 cells were detected by anti-GPV sera, anti-VP3 sera, and anti-His antibodies, respectively.	Histidine	104-107	VP3	Goose parvovirus	21-24
21530495-6	2011	These findings implicate a conserved histidine as critical for DNLZ regulation of mitochondrial HSPA9 catalytic activity.	Histidine	37-46	heat shock protein family A (Hsp70) member 9	Homo sapiens	96-101
21480614-10	2011	Canonical and alternative CBS assays suggest that maintaining the native heme ligation motif of wild-type Fe hCBS (Cys/His) is essential in maintaining maximal activity in Co hCBS.	Histidine	119-122	cystathionine beta-synthase	Homo sapiens	26-29
21480614-6	2011	The peak positions and intensities of the electronic absorption and MCD spectra of Co(III) hCBS are distinct from those of previously Co-substituted heme proteins; TD-DFT calculations reveal that the unique features arise from the 6-coordinate Co bound axially by cysteine(thiolate) and a neutral donor, presumably histidine.	Histidine	315-324	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	86-89
21354327-6	2011	The addition of dicoumarol, a DT-diaphorase inhibitor, decreased the number of danthron-induced histidine revertants by 35-39%, indicating that DT-diaphorase is involved in the metabolic activation of danthron in the presence of NADH as an electron donor.	Histidine	96-105	NAD(P)H quinone dehydrogenase 1	Homo sapiens	144-157
21462967-6	2011	One to 5 adducts were formed on insulin through Michael adduction, involving histidine residues.	Histidine	77-86	insulin	Homo sapiens	32-39
21480614-6	2011	The peak positions and intensities of the electronic absorption and MCD spectra of Co(III) hCBS are distinct from those of previously Co-substituted heme proteins; TD-DFT calculations reveal that the unique features arise from the 6-coordinate Co bound axially by cysteine(thiolate) and a neutral donor, presumably histidine.	Histidine	315-324	cystathionine beta-synthase	Homo sapiens	91-95
21480614-10	2011	Canonical and alternative CBS assays suggest that maintaining the native heme ligation motif of wild-type Fe hCBS (Cys/His) is essential in maintaining maximal activity in Co hCBS.	Histidine	119-122	cystathionine beta-synthase	Homo sapiens	109-113
21480614-10	2011	Canonical and alternative CBS assays suggest that maintaining the native heme ligation motif of wild-type Fe hCBS (Cys/His) is essential in maintaining maximal activity in Co hCBS.	Histidine	119-122	cystathionine beta-synthase	Homo sapiens	175-179
21445432-3	2011	Proteins such as cytochrome c oxidase, a crucial enzyme in the respiratory chain, and beta-amyloid peptide, implicated in the pathology of Alzheimer"s disease, are examples of proteins containing histidines in their coordination sphere.	Histidine	196-206	amyloid beta precursor protein	Homo sapiens	86-106
21449573-3	2011	It has been confirmed that FXYD1 spontaneously associates in vitro with the alpha(1)/His(10)-beta(1) complex and stabilizes it in an active mode.	Histidine	85-88	FXYD domain containing ion transport regulator 1	Homo sapiens	27-32
21449573-3	2011	It has been confirmed that FXYD1 spontaneously associates in vitro with the alpha(1)/His(10)-beta(1) complex and stabilizes it in an active mode.	Histidine	85-88	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	93-100
21449573-4	2011	The functional properties of the alpha(1)/His(10)-beta(1) and alpha(1)/His(10)-beta(1)/FXYD1 complexes have been investigated by fluorescence methods.	Histidine	71-74	FXYD domain containing ion transport regulator 1	Homo sapiens	87-92
21563331-0	2004	(68)Ga-DOTA-4-amino-1-carboxymethyl-piperidine-D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2 The amphibian bombesin (BBN or BN, a peptide of 14 amino acids) is an analog of human gastrin-releasing peptide (GRP, a peptide of 27 amino acids) that binds to GRP receptor (GRPR) with high affinity and specificity (1).	Histidine	73-76	gastrin releasing peptide receptor	Homo sapiens	250-262
21563332-0	2004	(111)In-DOTA-4-amino-1-carboxymethyl-piperidine-D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2 The amphibian bombesin (BBN or BN, a peptide of 14 amino acids) is an analog of human gastrin-releasing peptide (GRP, a peptide of 27 amino acids) that binds to GRP receptor (GRPR) with high affinity and specificity (1).	Histidine	74-77	gastrin releasing peptide receptor	Homo sapiens	251-263
21563332-0	2004	(111)In-DOTA-4-amino-1-carboxymethyl-piperidine-D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2 The amphibian bombesin (BBN or BN, a peptide of 14 amino acids) is an analog of human gastrin-releasing peptide (GRP, a peptide of 27 amino acids) that binds to GRP receptor (GRPR) with high affinity and specificity (1).	Histidine	74-77	gastrin releasing peptide receptor	Homo sapiens	265-269
21573188-0	2011	Histidine-mediated pH-sensitive regulation of M-ficolin:GlcNAc binding activity in innate immunity examined by molecular dynamics simulations.	Histidine	0-9	ficolin 1	Homo sapiens	46-55
21563331-0	2004	(68)Ga-DOTA-4-amino-1-carboxymethyl-piperidine-D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2 The amphibian bombesin (BBN or BN, a peptide of 14 amino acids) is an analog of human gastrin-releasing peptide (GRP, a peptide of 27 amino acids) that binds to GRP receptor (GRPR) with high affinity and specificity (1).	Histidine	73-76	gastrin releasing peptide receptor	Homo sapiens	264-268
21277849-8	2011	Increased lysosomal histidine, in the absence of SLC15A4, appears to negatively regulate Toll-like receptor 9 function by inhibiting the proteolytic activities of cathepsins B and L. SLC15A4(-/-) mice also had a severe defect in NOD1-dependent cytokine production, indicating that SLC15A4 functions as a transporter of the NOD1 ligand.	Histidine	20-29	solute carrier family 15, member 4	Mus musculus	183-190
21277849-8	2011	Increased lysosomal histidine, in the absence of SLC15A4, appears to negatively regulate Toll-like receptor 9 function by inhibiting the proteolytic activities of cathepsins B and L. SLC15A4(-/-) mice also had a severe defect in NOD1-dependent cytokine production, indicating that SLC15A4 functions as a transporter of the NOD1 ligand.	Histidine	20-29	solute carrier family 15, member 4	Mus musculus	183-190
21321129-7	2011	In addition, the strongly conserved His(195) within the motif HPHG, which may play a role in the active site of DGAT2, is likely embedded in the membrane.	Histidine	36-39	diacylglycerol O-acyltransferase 2	Mus musculus	112-117
21187684-7	2011	However C-terminal truncated VP7 with His-tag failed to react with this monoclonal antibody, while poor antigenicity was evident when it was reacted with infected bovine serum.	Histidine	38-41	VP7	Bluetongue virus	29-32
21315081-6	2011	This approach uses a gold nanoparticle that recognizes a histidine tag on an ABP and an image analysis procedure that can determine the polarity of the actin filament.	Histidine	57-66	sex hormone binding globulin	Homo sapiens	77-80
21205829-5	2011	Additional mutations of His-155 and Ala-348 in the hP2X(7) receptor to residues with diverse side chains revealed a different dependence on the side chain properties, supporting the specificity of these two residues.	Histidine	24-27	purinergic receptor P2X 7	Homo sapiens	51-67
21396910-0	2011	A single replacement of histidine to arginine in EGFR-lytic hybrid peptide demonstrates the improved anticancer activity.	Histidine	24-33	epidermal growth factor receptor	Homo sapiens	49-53
21396910-3	2011	When cytotoxic activity of EGFR-lytic or EGFR(2R)-lytic hybrid peptides was investigated in various human cancer and normal cell lines, it was demonstrated that EGFR(2R)-lytic, in which second histidine (H) of EGFR-binding peptide was replaced to arginine (R) had 1.2-1.9-fold higher cytotoxic activity than that of original EGFR-lytic peptide.	Histidine	193-202	epidermal growth factor receptor	Homo sapiens	27-31
21306562-5	2011	Site-directed mutagenesis of the catalytic tetrad of AKR1B1, composed of Tyr, Lys, His and Asp, revealed that the triad of Asp43, Lys77 and His110, but not Tyr48, acts as a proton donor in most AKR activities, and is crucial for PGD(2) and PGF(2alpha) synthase activities.	Histidine	83-86	aldo-keto reductase family 1 member B	Homo sapiens	53-59
21488149-4	2011	Six histidine single mutants of HSA, H9A, H39A, H67A, H105A, H128A and H146A were produced and photolabeled with [(14) C]KP at pH 6.5, 7.4 and 8.2 and the role of each histidine in causing the N-B transition induced allosteric ligand binding was examined.	Histidine	4-13	albumin	Homo sapiens	32-35
21375246-7	2011	We tested this hypothesis by expressing a Ctr1 mutant lacking only extracellular histidine residues in Ctr1-knockout mouse embryonic fibroblasts.	Histidine	81-90	solute carrier family 31, member 1	Mus musculus	42-46
21205829-2	2011	Here, we investigated the mechanisms determining the P2X(7) receptor function by following two human single-nucleotide polymorphism (SNP) mutations that replace His-155 and Ala-348 in the human (h) P2X(7) receptor with the corresponding residues, Tyr-155 and Thr-348, in the rat (r) P2X(7) receptor.	Histidine	161-164	purinergic receptor P2X 7	Homo sapiens	53-68
21341665-4	2011	Selective quenching observed in (13)C SSNMR of Cu(2+)-bound Abeta(1-40) suggested that primary Cu(2+) binding sites in Abeta(1-40) fibrils include N(epsilon) in His-13 and His-14 and carboxyl groups in Val-40 as well as in Glu sidechains (Glu-3, Glu-11, and/or Glu-22).	Histidine	161-164	amyloid beta precursor protein	Homo sapiens	60-65
21341665-4	2011	Selective quenching observed in (13)C SSNMR of Cu(2+)-bound Abeta(1-40) suggested that primary Cu(2+) binding sites in Abeta(1-40) fibrils include N(epsilon) in His-13 and His-14 and carboxyl groups in Val-40 as well as in Glu sidechains (Glu-3, Glu-11, and/or Glu-22).	Histidine	172-175	amyloid beta precursor protein	Homo sapiens	60-65
21205829-6	2011	Substitutions of the residues surrounding His-155 and Ala-348 in the hP2X(7) receptor with the equivalent ones in the rP2X(7) receptor also affected ATP-induced currents but were not fully reminiscent of the H155Y and A348T effects.	Histidine	42-45	purinergic receptor P2X 7	Homo sapiens	69-85
21117662-5	2011	There is also a contribution from the C-terminus in conjunction with the histidine at position 50 in alpha-synuclein and position 65 in beta-synuclein, although these regions appear to have little effect on overall coordination stability.	Histidine	73-82	synuclein beta	Homo sapiens	136-150
21281641-0	2011	Histidine 416 of the periplasmic binding protein NikA is essential for nickel uptake in Escherichia coli.	Histidine	0-9	relaxosome component	Escherichia coli	49-53
21167174-8	2011	The metal binding site in PHF2 closely resembles the Fe(2+) sites in other Jumonji domains examined, with one important difference-a tyrosine (Y321 of PHF2) replaces histidine as the fifth ligand.	Histidine	166-175	PHD finger protein 2	Homo sapiens	26-30
21167174-8	2011	The metal binding site in PHF2 closely resembles the Fe(2+) sites in other Jumonji domains examined, with one important difference-a tyrosine (Y321 of PHF2) replaces histidine as the fifth ligand.	Histidine	166-175	PHD finger protein 2	Homo sapiens	151-155
21123176-9	2011	A His-248/His-250 Zn(2+)-mediated intermolecular bridge was observed in a catalytic domain crystal structure (Protein Data Bank code 3IR2); however, atomic force microscopy analyses showed that the stoichiometry of the A3G-ssDNA complexes changed insignificantly when these residues were mutated to Ala.	Histidine	2-5	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	Homo sapiens	219-222
21123176-9	2011	A His-248/His-250 Zn(2+)-mediated intermolecular bridge was observed in a catalytic domain crystal structure (Protein Data Bank code 3IR2); however, atomic force microscopy analyses showed that the stoichiometry of the A3G-ssDNA complexes changed insignificantly when these residues were mutated to Ala.	Histidine	10-13	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	Homo sapiens	219-222
21036805-0	2011	Inhibitory effect of extracellular histidine on cobalt-induced HIF-1alpha expression.	Histidine	35-44	hypoxia inducible factor 1 subunit alpha	Homo sapiens	63-73
21149573-9	2011	Expression of a V5-His-tagged form of Cnc-C revealed that the transcription factor is itself a proteasome substrate that is stabilized when the proteasome is inhibited.	Histidine	19-22	cap-n-collar	Drosophila melanogaster	38-43
20937357-2	2011	Previously we have found that a C-terminal His(6)-tag destroys the bioactivity of growth differentiation-9 (GDF9, a homolog of BMP15).	Histidine	43-46	bone morphogenetic protein 15	Homo sapiens	127-132
21194956-4	2011	Three cyclic-azo somatostatin analogs and three cyclic-azo BNP analogs were effectively prepared in solution through azo bond formation between p-amino phenylalanine and His or Tyr residues that were positioned in the peptide sequences in place of the native Cys residues.	Histidine	170-173	natriuretic peptide B	Rattus norvegicus	59-62
21177244-6	2011	Further support for this idea was obtained by mutating NBD2 amino acids His(1364) and Arg(1367) at the CL5 interface, which also resulted in reduced MRP1 levels.	Histidine	72-75	ATP binding cassette subfamily B member 1	Homo sapiens	149-153
21630593-1	2011	A previous work suggested that peptides from the histidine-containing copper-binding motifs in human prion protein (PrP) function as peroxidase-like biocatalysts catalyzing the generation of superoxide anion radicals in the presence of neurotransmitters (aromatic monoamines) and phenolics such as tyrosine and tyrosyl residues on proteins.	Histidine	49-58	prion protein	Homo sapiens	116-119
21167151-5	2011	The intake of histidine or carnosine significantly diminished the activity and mRNA expression of malic enzyme, FAS, HMG-CoA reductase, SREBP-1c and SREBP-2, which led to lower body weight, epididymal fat, and hepatic triglyceride and cholesterol levels (P&lt;0.05).	Histidine	14-23	fatty acid synthase	Mus musculus	112-115
21347309-4	2011	This domain comprises a pentapeptide sequence motif GxSxG/S at the N-terminus and conserved amino acid residues Ser, Asp and His that constitute a catalytic triad characteristic of lipase, esterase and cutinase activity.	Histidine	125-128	esterase	Mycobacterium tuberculosis H37Rv	189-197
21116528-0	2011	Serine protease acylation proceeds with a subtle re-orientation of the histidine ring at the tetrahedral intermediate.	Histidine	71-80	coagulation factor II, thrombin	Homo sapiens	0-15
21036805-5	2011	Analysis of causal nutrients has revealed that histidine, which is contained richer in DMEM, acts as the inhibitory nutrient for cobalt-induced HIF-1alpha expression of MCF-7 cells in DMEM.	Histidine	47-56	hypoxia inducible factor 1 subunit alpha	Homo sapiens	144-154
20709173-5	2011	We utilize N-terminally His-tagged MKK4 that is coexpressed in E. coli with a constitutively active form of MEKK1.	Histidine	24-27	mitogen-activated protein kinase kinase 4	Homo sapiens	35-39
20709173-6	2011	This phosphorylated, active His-MKK4 is purified by Ni-NTA chromatography and used to phosphorylate milligram amounts of three different isoforms of human JNKs (JNK1alpha1, JNK1alpha2 and JNK2alpha2) that had separately been expressed and purified from E. coli in their inactive forms.	Histidine	28-31	mitogen-activated protein kinase kinase 4	Homo sapiens	32-36
21134455-2	2011	Histidine at position 1042 of the p150 region of the KRT vaccine strain was found to be responsible for ts, while wild-type viruses had tyrosine at position 1042 (Vaccine 27; 234-42, 2009).	Histidine	0-9	keratin 126, pseudogene	Homo sapiens	53-56
21290630-0	2004	[(99m)Tc(CO)3](+)-Labeled anti-epidermal growth factor receptor (HER2) affibody ZHER2:342 with a tri-(histidine-glutamate) peptide tag (HE)3 on the N-terminal Overexpression of the epidermal growth factor receptor type 2 (HER2) is a characteristic feature of a variety of cancers, and HER2 levels in tumors (primary or metastatic) are often used to screen for patients who would benefit from anti-HER2 antibody (Ab) therapy (e.g., for breast cancer), to determine the efficacy of a treatment regimen, or to predict the prognostic outcome for a patient (1).	Histidine	102-111	epidermal growth factor receptor	Homo sapiens	31-63
21290630-0	2004	[(99m)Tc(CO)3](+)-Labeled anti-epidermal growth factor receptor (HER2) affibody ZHER2:342 with a tri-(histidine-glutamate) peptide tag (HE)3 on the N-terminal Overexpression of the epidermal growth factor receptor type 2 (HER2) is a characteristic feature of a variety of cancers, and HER2 levels in tumors (primary or metastatic) are often used to screen for patients who would benefit from anti-HER2 antibody (Ab) therapy (e.g., for breast cancer), to determine the efficacy of a treatment regimen, or to predict the prognostic outcome for a patient (1).	Histidine	102-111	erb-b2 receptor tyrosine kinase 2	Homo sapiens	65-69
21325825-1	2011	The glutamine transporter SNAT3 (SLC38A3), which also transports asparagine and histidine, exchanges sodium for protons, and displays a non-stoichiometrical conductance, which is suppressed by the catalytic activity of carbonic anhydrase II (CAII).	Histidine	80-89	carbonic anhydrase 2	Rattus norvegicus	219-240
20882602-2	2011	We report design, synthesis evaluation of biological activity, and a preliminary mechanistic study of epipolythiodiketopiperazine (ETP) transcriptional antagonist that targets the interaction between the C-terminal transactivation domain (C-TAD) of hypoxia-inducible factor 1alpha (HIF-1alpha) and cysteine-histidine rich region (CH1) of transcriptional coactivator p300/CBP.	Histidine	307-316	hypoxia inducible factor 1 subunit alpha	Homo sapiens	249-280
21325825-1	2011	The glutamine transporter SNAT3 (SLC38A3), which also transports asparagine and histidine, exchanges sodium for protons, and displays a non-stoichiometrical conductance, which is suppressed by the catalytic activity of carbonic anhydrase II (CAII).	Histidine	80-89	carbonic anhydrase 2	Rattus norvegicus	242-246
20889499-0	2010	Two independent histidines, one in human prolactin and one in its receptor, are critical for pH-dependent receptor recognition and activation.	Histidine	16-26	prolactin	Homo sapiens	41-50
21804240-1	2011	The structural conversion of the prion protein (PrP) from the normal cellular isoform (PrP(C)) to the posttranslationally modified form (PrP(Sc)) is thought to relate to Cu2+ binding to histidine (H) residues.	Histidine	186-195	prion protein	Homo sapiens	48-51
21804240-1	2011	The structural conversion of the prion protein (PrP) from the normal cellular isoform (PrP(C)) to the posttranslationally modified form (PrP(Sc)) is thought to relate to Cu2+ binding to histidine (H) residues.	Histidine	186-195	prion protein	Homo sapiens	87-93
21804240-1	2011	The structural conversion of the prion protein (PrP) from the normal cellular isoform (PrP(C)) to the posttranslationally modified form (PrP(Sc)) is thought to relate to Cu2+ binding to histidine (H) residues.	Histidine	186-195	prion protein	Homo sapiens	87-90
20890717-7	2011	The connection between the metal center and His(alpha323) is proposed to be responsible for maintaining the flap conformation.	Histidine	44-47	arachidonate 5-lipoxygenase activating protein	Homo sapiens	108-112
20940308-3	2010	We suggest that the enzyme responsible for nucleoside 5"-O-monophosphorothioate ((d)NMPS) metabolism could be histidine triad nucleotide-binding protein 1 (Hint-1), a phosphoramidase belonging to the histidine triad (HIT) superfamily that is present in all forms of life.	Histidine	110-119	histidine triad nucleotide binding protein 1	Homo sapiens	156-162
21734345-7	2011	Analysis of combinations showed a significant association of 113His/His EPHX1/null-GSTM1 (OR=4.07) and null-GSTM1/105Val/Val GSTP1 (OR =3.56) genotypes with increased risk of COPD (respectively P=0.0094 and P=0.0153).	Histidine	64-67	glutathione S-transferase mu 1	Homo sapiens	83-88
21434831-3	2011	Sequence analysis of WT1 demonstrated a G-to-A substitution in exon 8 of the gene (c.1097G &gt; A), resulting in an arginine-to-histidine (R366H) substitution in the second zinc finger domain.	Histidine	128-137	WT1 transcription factor	Homo sapiens	21-24
20952238-7	2011	In the CYP2D6 gene, homozygosity for CYP2D6*10, which is associated with significantly reduced metabolic activity, was found in 3 cases, while 2 cases carried a different previously unreported missense mutation ((344)Arg&gt;Gln and (48)His&gt;Tyr).	Histidine	236-239	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	7-13
20952238-7	2011	In the CYP2D6 gene, homozygosity for CYP2D6*10, which is associated with significantly reduced metabolic activity, was found in 3 cases, while 2 cases carried a different previously unreported missense mutation ((344)Arg&gt;Gln and (48)His&gt;Tyr).	Histidine	236-239	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	37-43
20709172-2	2011	Recombinant CDH without the native signal sequence and fused with a His(6)-tag (rNC-CDH1) was successfully expressed and secreted.	Histidine	68-71	cdh-2	Neurospora crassa OR74A	12-15
21187975-3	2010	The presence of the same consensus sequence, Val(12)-His-His-Gln(15), near the presumptive alpha-secretase cleavage site of the amyloid-beta (Abeta) peptide led us to hypothesize that NIa could possess activity against Abeta.	Histidine	53-56	amyloid beta precursor protein	Homo sapiens	142-147
21187975-3	2010	The presence of the same consensus sequence, Val(12)-His-His-Gln(15), near the presumptive alpha-secretase cleavage site of the amyloid-beta (Abeta) peptide led us to hypothesize that NIa could possess activity against Abeta.	Histidine	53-56	amyloid beta precursor protein	Homo sapiens	219-224
21187975-3	2010	The presence of the same consensus sequence, Val(12)-His-His-Gln(15), near the presumptive alpha-secretase cleavage site of the amyloid-beta (Abeta) peptide led us to hypothesize that NIa could possess activity against Abeta.	Histidine	57-60	amyloid beta precursor protein	Homo sapiens	142-147
21187975-3	2010	The presence of the same consensus sequence, Val(12)-His-His-Gln(15), near the presumptive alpha-secretase cleavage site of the amyloid-beta (Abeta) peptide led us to hypothesize that NIa could possess activity against Abeta.	Histidine	57-60	amyloid beta precursor protein	Homo sapiens	219-224
21094140-9	2010	Through the pattern changes in urinary metabolites of HFD-fed AHNAK(-/-) mice, our data suggest that the strong resistance to HFD-induced obesity in AHNAK(-/-) mice comes from perturbations of amino acids, such as methionine, putrescine, threonine, and histidine, which are related to fat metabolism.	Histidine	253-262	AHNAK nucleoprotein (desmoyokin)	Mus musculus	149-154
21077593-3	2010	Demetalation of the porphyrin destabilizes the folded structure of cytochrome c owing to the loss of the axial metal-histidine and metal-methionine bonds.	Histidine	117-126	cytochrome c, somatic	Homo sapiens	67-79
20855895-4	2010	Kinetic parameters were determined using a panel of synthetic carboxypeptidase substrates, indicating a preference of CPA6 for large hydrophobic C-terminal amino acids and only very weak activity toward small amino acids and histidine.	Histidine	225-234	carboxypeptidase A6	Homo sapiens	118-122
20855298-6	2010	Pre-treatment of laminin-coated plates with His(6)t-S-CD decreased the attachment of cells, suggesting that the recombinant matriptase caused detachment through a mechanism involving a direct effect on laminin.	Histidine	44-47	ST14 transmembrane serine protease matriptase	Rattus norvegicus	124-134
21053902-4	2010	The reorganization free energies for ET from the heme cofactors of cytochrome c and b(5) to solvent exposed Ru-complexes docked to histidine residues at the surface of these proteins fall within a narrow range of 1.2-1.3 eV.	Histidine	131-140	cytochrome c, somatic	Homo sapiens	67-79
21028829-2	2010	The shortest PTH analogue displaying nanomolar potency is the undecapeptide H-Aib-Val-Aib-Glu-Ile-Gln-Leu-Nle-His-Gln-Har-NH(2) that contains two helix-stabilizing residues (Aib(1,3)).	Histidine	110-113	parathyroid hormone	Homo sapiens	13-16
20690142-6	2010	Arg-Glc and His-Glc MRPs exhibited strong TAC and PPO inhibition.	Histidine	12-15	protoporphyrinogen oxidase	Homo sapiens	50-53
21047126-2	2010	The angiotensin II metabolite angiotensin IV (Ang IV, Val(1)-Tyr(2)-Ile(3)-His(4)-Pro(5)-Phe(6)) binds with high affinity to IRAP and inhibits this aminopeptidase (K(i) = 62.4 nM).	Histidine	75-78	leucyl and cystinyl aminopeptidase	Homo sapiens	125-129
21047126-4	2010	It is herein reported that displacement of the C-terminal tripeptide His(4)-Pro(5)-Phe(6) with a phenylacetic acid functionality combined with a constrained macrocyclic system in the N-terminal affords potent IRAP inhibitors that are less peptidic in character than the hexapeptide Ang IV.	Histidine	69-72	leucyl and cystinyl aminopeptidase	Homo sapiens	209-213
20977208-1	2010	The octapeptide angiotensin II (Ang II; Asp(1)-Arg(2)-Val(3)-Tyr(4)-Ile(5)-His(6)-Pro(7)-Phe(8)) is the primary active hormone of the renin/angiotensin system (RAS) and has been implicated in various cardiovascular diseases.	Histidine	75-78	angiotensinogen	Homo sapiens	16-30
21092292-0	2010	Dishevelled-3 C-terminal His single amino acid repeats are obligate for Wnt5a activation of non-canonical signaling.	Histidine	25-28	Wnt family member 5A	Homo sapiens	72-77
20832396-5	2010	Affinity chromatography utilizing histidine tagged sV23 alleles revealed small sV23 disulfide linked complexes during the early stages of eggshell formation that included other VMPs, namely sV17 and Vml.	Histidine	34-43	Vitelline membrane 26Ab	Drosophila melanogaster	51-55
20832396-5	2010	Affinity chromatography utilizing histidine tagged sV23 alleles revealed small sV23 disulfide linked complexes during the early stages of eggshell formation that included other VMPs, namely sV17 and Vml.	Histidine	34-43	Vitelline membrane 26Ab	Drosophila melanogaster	79-83
21092292-8	2010	Phenylalanine (Phe)-substitution of the same His-repeats in Dvl3 mimics Wnt5a stimulated NF-AT-sensitive transcription.	Histidine	45-48	Wnt family member 5A	Homo sapiens	72-77
20977208-1	2010	The octapeptide angiotensin II (Ang II; Asp(1)-Arg(2)-Val(3)-Tyr(4)-Ile(5)-His(6)-Pro(7)-Phe(8)) is the primary active hormone of the renin/angiotensin system (RAS) and has been implicated in various cardiovascular diseases.	Histidine	75-78	renin	Homo sapiens	134-139
20718410-3	2010	Here, we examine the stability of human PrP(C) with pH and find that PrP(C) fold stability is significantly reduced by the protonation of two histidine residues, His187 and His155.	Histidine	142-151	prion protein	Homo sapiens	40-46
20574831-3	2010	The highly active EH mutant with a his-tag was immobilized onto magnetic silica assembled with NiO nanoparticles.	Histidine	35-38	epoxide hydrolase 1, microsomal	Mus musculus	18-20
20939497-0	2010	Conformational changes in the g protein-coupled receptor rhodopsin revealed by histidine hydrogen-deuterium exchange.	Histidine	79-88	rhodopsin	Homo sapiens	57-66
20939497-3	2010	The half-lives of His-HDX indicate clear differences in the solvent accessibility of three His residues in rhodopsin/opsin and Zn2+-dependent changes in the pKa for His195.	Histidine	18-21	rhodopsin	Homo sapiens	107-116
21079777-7	2010	The most important difference between CFP and Cerulean is a histidine residue at position 148.	Histidine	60-69	complement factor properdin	Homo sapiens	38-41
21079777-8	2010	Indeed, changing this histidine in CFP into an aspartic acid results in identical fluorescence properties as observed for the Cerulean fluorescent based FRET sensor.	Histidine	22-31	complement factor properdin	Homo sapiens	35-38
21079777-9	2010	We therefore conclude that the changes in fluorescence lifetime of CFP are affected specifically by possible electrostatic interactions of the negative charge of ATP with the positively charged histidine at position 148.	Histidine	194-203	complement factor properdin	Homo sapiens	67-70
20204369-6	2010	Sonodynamically induced apoptosis, caspase-3 activation, and nitroxide generation were significantly suppressed by histidine.	Histidine	115-124	caspase 3	Homo sapiens	35-44
20204369-8	2010	The significant reduction in sonodynamically induced apoptosis, nitroxide generation, and caspase-3 activation by histidine suggests that active species such as singlet oxygen are important in the sonodynamic induction of apoptosis.	Histidine	114-123	caspase 3	Homo sapiens	90-99
20708916-8	2010	The developed QD-based sensor gives excellent selectivity for histidine over other amino acids with the limit of detection (3 s) of 0.3 muM.	Histidine	62-71	latexin	Homo sapiens	136-139
20708916-9	2010	The relative standard deviation for 11 replicate detections of 15 muM histidine was 2.7%.	Histidine	70-79	latexin	Homo sapiens	66-69
20718410-3	2010	Here, we examine the stability of human PrP(C) with pH and find that PrP(C) fold stability is significantly reduced by the protonation of two histidine residues, His187 and His155.	Histidine	142-151	prion protein	Homo sapiens	40-43
20728388-7	2010	Of these, the ND1 T3394C mutation caused the substitution of a highly conserved histidine for tyrosine (Y30H) at amino acid position 30.	Histidine	80-89	mitochondrially encoded NADH dehydrogenase 1	Homo sapiens	14-17
20660104-4	2010	We found the permeability of GlySar to be saturable (K(m) = 5.7 mM), pH-dependent (maximal value at pH 5.5), and specific for PEPT1; other peptide transporters, such as PHT1 and PHT2, were not involved, as judged by the lack of GlySar inhibition by excess concentrations of histidine.	Histidine	274-283	solute carrier family 15, member 4	Mus musculus	169-173
20806312-2	2010	Previously we reported a metabolically stable (N(alpha)His)Ac-betaAla-betaAla-[Cha(13),Nle(14)]BBS(7-14) analogue with high affinity for the GRPR.	Histidine	55-58	gastrin releasing peptide receptor	Homo sapiens	141-145
20630863-4	2010	A 1.25 A x-ray crystal structure of Ncb5or-b(5) reveals nearly orthogonal planes of the imidazolyl rings of heme-ligating residues His(89) and His(112), consistent with a highly anisotropic low spin EPR spectrum.	Histidine	131-134	cytochrome b5 reductase 4	Homo sapiens	36-42
20663104-1	2010	HLA-A*11:57 allele was different from HLA-A*11:16 by single nucleotide substitution at codon 145(CAC&gt;CGC), resulting in one amino acid change His to Arg.	Histidine	145-148	major histocompatibility complex, class I, A	Homo sapiens	0-5
20663104-1	2010	HLA-A*11:57 allele was different from HLA-A*11:16 by single nucleotide substitution at codon 145(CAC&gt;CGC), resulting in one amino acid change His to Arg.	Histidine	145-148	major histocompatibility complex, class I, A	Homo sapiens	38-43
20735046-4	2010	We first carried out MD simulations of the active phosphorylated Akt in complex with its ligands under different protonation states of His 196, the phosphothreonine-coordinating residue found in the alphaC helix.	Histidine	135-138	AKT serine/threonine kinase 1	Homo sapiens	65-68
20630863-4	2010	A 1.25 A x-ray crystal structure of Ncb5or-b(5) reveals nearly orthogonal planes of the imidazolyl rings of heme-ligating residues His(89) and His(112), consistent with a highly anisotropic low spin EPR spectrum.	Histidine	143-146	cytochrome b5 reductase 4	Homo sapiens	36-42
20630863-7	2010	However, Ncb5or-b(5) differs from Cyb5A with respect to location of the second heme ligand (His(112)) and of polypeptide conformation in its vicinity.	Histidine	92-95	cytochrome b5 reductase 4	Homo sapiens	9-15
20715794-6	2010	Zn(II)-loaded R246H GLX2-1 enzyme bound 2 equiv of Zn(II), and (1)H NMR spectra of the Co(II)-substituted analogue of this enzyme strongly suggest that the introduced histidine binds to Co(II).	Histidine	167-176	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
20715794-6	2010	Zn(II)-loaded R246H GLX2-1 enzyme bound 2 equiv of Zn(II), and (1)H NMR spectra of the Co(II)-substituted analogue of this enzyme strongly suggest that the introduced histidine binds to Co(II).	Histidine	167-176	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
20338153-15	2010	Determination of the three-dimensional structure of BChE and AChE conjugated to different OPs showed that aged adducts form a salt bridge with the protonated catalytic histidine.	Histidine	168-177	acetylcholinesterase (Cartwright blood group)	Homo sapiens	61-65
20858440-6	2010	The conformation of Nef was probed upon binding to Langmuir monolayers through the interaction of an N-terminal His tag with a synthetic metal-chelating lipid, which models one of the possible limiting cases for myr-Nef.	Histidine	112-115	S100 calcium binding protein B	Homo sapiens	20-23
20858440-8	2010	Binding of Nef through the N-terminal His tag apparently facilitates insertion of residues, as no insertion occurred upon binding of Nef through weak electrostatic interactions in the absence of the specific interaction through the His tag.	Histidine	38-41	S100 calcium binding protein B	Homo sapiens	11-14
20858440-8	2010	Binding of Nef through the N-terminal His tag apparently facilitates insertion of residues, as no insertion occurred upon binding of Nef through weak electrostatic interactions in the absence of the specific interaction through the His tag.	Histidine	232-235	S100 calcium binding protein B	Homo sapiens	11-14
20600753-9	2010	In Ames test, histidine-dependent auxotrophic mutants of Salmonella typhimurium (strains TA97, TA98, TA100, TA102 and TA1535) were used and incubated in the presence and absence of S9 metabolic activation using NSF extract with concentrations of 150-5000 microg/plate.	Histidine	14-23	N-ethylmaleimide sensitive factor, vesicle fusing ATPase	Rattus norvegicus	211-214
20435351-5	2010	The histidine residue in first position of the peptide chain of neurokinin A coordinates strongly to Cu(II) ion with histamine-like {NH(2), N(Im)} coordination mode.	Histidine	4-13	tachykinin precursor 1	Homo sapiens	64-76
20592032-13	2010	Modeling of the peptide:FcRn structure as compared with available structural data on Fc and FcRn suggest that the His-6 and Phe-7 (peptide) partially mimic the interaction of His-310 and Ile-253 (Fc) in binding to FcRn, but using a different backbone topology.	Histidine	114-117	Fc gamma receptor and transporter	Homo sapiens	24-28
20592032-13	2010	Modeling of the peptide:FcRn structure as compared with available structural data on Fc and FcRn suggest that the His-6 and Phe-7 (peptide) partially mimic the interaction of His-310 and Ile-253 (Fc) in binding to FcRn, but using a different backbone topology.	Histidine	114-117	Fc gamma receptor and transporter	Homo sapiens	92-96
20592032-13	2010	Modeling of the peptide:FcRn structure as compared with available structural data on Fc and FcRn suggest that the His-6 and Phe-7 (peptide) partially mimic the interaction of His-310 and Ile-253 (Fc) in binding to FcRn, but using a different backbone topology.	Histidine	114-117	Fc gamma receptor and transporter	Homo sapiens	92-96
20592032-13	2010	Modeling of the peptide:FcRn structure as compared with available structural data on Fc and FcRn suggest that the His-6 and Phe-7 (peptide) partially mimic the interaction of His-310 and Ile-253 (Fc) in binding to FcRn, but using a different backbone topology.	Histidine	175-178	Fc gamma receptor and transporter	Homo sapiens	24-28
20592032-13	2010	Modeling of the peptide:FcRn structure as compared with available structural data on Fc and FcRn suggest that the His-6 and Phe-7 (peptide) partially mimic the interaction of His-310 and Ile-253 (Fc) in binding to FcRn, but using a different backbone topology.	Histidine	175-178	Fc gamma receptor and transporter	Homo sapiens	92-96
20592032-13	2010	Modeling of the peptide:FcRn structure as compared with available structural data on Fc and FcRn suggest that the His-6 and Phe-7 (peptide) partially mimic the interaction of His-310 and Ile-253 (Fc) in binding to FcRn, but using a different backbone topology.	Histidine	175-178	Fc gamma receptor and transporter	Homo sapiens	92-96
20696886-5	2010	Although the aspartate-glutamate-alanine-histidine box motif (DEAH) domain of DHX36 was essential for CpG-A binding, the domain of unknown function 1605 (DUF1605 domain) of DHX9 was required for CpG-B binding.	Histidine	41-50	DEAH-box helicase 36	Homo sapiens	78-83
20662514-11	2010	Mutation of the histidines that flank the CXXC motifs results in a zinc site structure that is similar to holo-WT-HypA at neutral pH (Zn(Cys)(4)) and is no longer responsive to nickel binding or pH changes.	Histidine	16-26	pre-mRNA processing factor 40 homolog A	Homo sapiens	114-118
20815983-2	2010	METHODS: The expression vector Id3/pET32a was transformed into E.coli BL21(DE3) and expression of histidine (His)-tagged Id3 fusion protein was induced with IPTG and confirmed by SDS-PAGE and Western blot techniques.	Histidine	98-107	inhibitor of DNA binding 3, HLH protein	Homo sapiens	31-34
20815983-2	2010	METHODS: The expression vector Id3/pET32a was transformed into E.coli BL21(DE3) and expression of histidine (His)-tagged Id3 fusion protein was induced with IPTG and confirmed by SDS-PAGE and Western blot techniques.	Histidine	98-107	inhibitor of DNA binding 3, HLH protein	Homo sapiens	121-124
20815983-2	2010	METHODS: The expression vector Id3/pET32a was transformed into E.coli BL21(DE3) and expression of histidine (His)-tagged Id3 fusion protein was induced with IPTG and confirmed by SDS-PAGE and Western blot techniques.	Histidine	109-112	inhibitor of DNA binding 3, HLH protein	Homo sapiens	31-34
20815983-2	2010	METHODS: The expression vector Id3/pET32a was transformed into E.coli BL21(DE3) and expression of histidine (His)-tagged Id3 fusion protein was induced with IPTG and confirmed by SDS-PAGE and Western blot techniques.	Histidine	109-112	inhibitor of DNA binding 3, HLH protein	Homo sapiens	121-124
20696886-4	2010	CpG-A selectively bound the aspartate-glutamate-any amino acid-aspartate/histidine (DExD/H)-box helicase 36 (DHX36), whereas CpG-B selectively bound DExD/H-box helicase 9 (DHX9).	Histidine	73-82	DEAH-box helicase 36	Homo sapiens	109-114
20471432-5	2010	Surprisingly, substitution of Tyr7.31 with His, the corresponding residue in Y1, resulted in total loss of binding of iodinated porcine PYY.	Histidine	43-46	peptide YY	Homo sapiens	136-139
20467653-2	2010	Herein, we advanced the concept of moving affinity boundary (MAB) using metal ion Ni(II) and histidine (His) as the model inorganic ion and ligand, respectively, developed the simple method of MAB affinity capillary electrophoresis (MAB-ACE), and carried out the relative experiments.	Histidine	93-102	angiotensin I converting enzyme	Homo sapiens	237-240
20799012-8	2010	These results suggest that Tyr/His(1) and Ile/Thr(7) of GIP/GLP-1 peptides confer differential ligand selectivity toward GIPR and GLP1R.	Histidine	31-34	gastric inhibitory polypeptide	Homo sapiens	56-59
20799012-8	2010	These results suggest that Tyr/His(1) and Ile/Thr(7) of GIP/GLP-1 peptides confer differential ligand selectivity toward GIPR and GLP1R.	Histidine	31-34	glucagon	Homo sapiens	60-65
20799012-8	2010	These results suggest that Tyr/His(1) and Ile/Thr(7) of GIP/GLP-1 peptides confer differential ligand selectivity toward GIPR and GLP1R.	Histidine	31-34	gastric inhibitory polypeptide receptor	Homo sapiens	121-125
20659345-14	2010	As expected, Cys55 modification reduced the strength of the interaction between Nef-His and CD4 tail peptide by 50%.	Histidine	84-87	S100 calcium binding protein B	Homo sapiens	80-83
20659345-14	2010	As expected, Cys55 modification reduced the strength of the interaction between Nef-His and CD4 tail peptide by 50%.	Histidine	84-87	CD4 molecule	Homo sapiens	92-95
20467653-2	2010	Herein, we advanced the concept of moving affinity boundary (MAB) using metal ion Ni(II) and histidine (His) as the model inorganic ion and ligand, respectively, developed the simple method of MAB affinity capillary electrophoresis (MAB-ACE), and carried out the relative experiments.	Histidine	104-107	angiotensin I converting enzyme	Homo sapiens	237-240
20467653-3	2010	The experiments manifested that (a) an MAB could be created with the model metal ion and ligand; (b) the MAB-ACE could specifically capture His rather than other amino acids, or numerous metabolites in human urine; and (c) the capture had the merits of simultaneous focusing and separation to the target metabolite of His.	Histidine	140-143	angiotensin I converting enzyme	Homo sapiens	109-112
20467653-5	2010	The analyses of His in raw urine by the MAB-ACE are in agreement with those via the standard amino acid analyzer, indicating the reliability of the developed method.	Histidine	16-19	angiotensin I converting enzyme	Homo sapiens	44-47
20497104-4	2010	D-Lys6-GnRH and [Asn1-Val5]-angiotensin II were modified at their histidine side chain within the peptide, whilst IGF-1 (1-3) was modified at the C-terminal glutamic acid residue.	Histidine	66-75	angiotensinogen	Homo sapiens	28-42
20332014-10	2010	GENERAL SIGNIFICANCE: These results indicate that an Escherichiacoli-derived full-length His(8)-tagged human MUC17 CRD1-L-CRD2 recombinant protein is a biologically active candidate for further development as a therapeutic agent.	Histidine	89-92	CORD1	Homo sapiens	115-119
20553503-6	2010	Cytoglobin displays biphasic kinetics after the photolysis of CO, as a result of competition with an internal protein ligand, the E7 distal histidine.	Histidine	140-149	cytoglobin	Homo sapiens	0-10
20565749-9	2010	An exogenous His-tag fusion p16INK4a protein was obtained and purified by affinity chromatography.	Histidine	13-16	cyclin dependent kinase inhibitor 2A	Homo sapiens	28-36
20460111-7	2010	In this study we show, that denuded IQ2 favours a closed conformation of myosin with a low HIS-MLC-1 binding affinity.	Histidine	91-94	modulator of VRAC current 1	Homo sapiens	95-100
20459130-0	2010	fac-{Ru(CO)(3)}(2+) selectively targets the histidine residues of the beta-amyloid peptide 1-28.	Histidine	44-53	FA complementation group C	Homo sapiens	0-3
20642005-12	2004	A lactam bridge-cyclized alpha-MSH analog, GlyGlu-c[Lys-Nlc-Glu-His-d-Phe-Arg-Trp-Gly-Arg-Pro-Val-Asp] (GlyGlu-CycMSH), was conjugated with DOTA (11).	Histidine	64-67	proopiomelanocortin	Homo sapiens	25-34
20553503-7	2010	An internal disulfide bond may form which modifies the rate of dissociation of the distal histidine and apparently leads to different cytoglobin conformations, which may affect the observed oxygen affinity by an order of magnitude.	Histidine	90-99	cytoglobin	Homo sapiens	134-144
20211729-2	2010	In the present study, we examined whether extracellularly located histidine residues of GPR4 sense extracellular protons and, if so, whether a certain histidine residue is critical for coupling to the single or multiple signaling pathway(s).	Histidine	66-75	G protein-coupled receptor 4	Homo sapiens	88-92
20387063-2	2010	This allele carries a coding polymorphism in the first epidermal growth factor-like domain of CD93, which results in an amino acid substitution from Asn--&gt;His at position 264.	Histidine	158-161	CD93 antigen	Mus musculus	94-98
20436486-5	2010	Owing to their electrophilic nature, EFOX adducted to cysteine and histidine residues of proteins and activated Nrf2-dependent anti-oxidant gene expression.	Histidine	67-76	NFE2 like bZIP transcription factor 2	Homo sapiens	112-116
20211729-3	2010	We found that the mutation of histidine residue at 79, 165, or 269 from the N-terminal of GPR4 to phenylalanine shifted the half-maximal effective concentration (EC(50)) of proton-induced signaling activities to the right, including cAMP accumulation, SRE promoter activity reflecting Rho activity, and NFAT promoter activity reflecting phospholipase C signaling activity, without an appreciable change in the maximal activities.	Histidine	30-39	G protein-coupled receptor 4	Homo sapiens	90-94
20211729-0	2010	Each one of certain histidine residues in G-protein-coupled receptor GPR4 is critical for extracellular proton-induced stimulation of multiple G-protein-signaling pathways.	Histidine	20-29	G protein-coupled receptor 4	Homo sapiens	69-73
20211729-4	2010	These results suggest that the protonation of each one of histidine residues at 79, 165, and 269 in GPR4 may be critical for conformational change of the receptor for coupling to multiple intracellular signaling pathways through G-proteins.	Histidine	58-67	G protein-coupled receptor 4	Homo sapiens	100-104
20304006-5	2010	This ataxin-1 protein was expressed in Escherichia coli as a fusion protein with a GST tag at the N-terminus and a double (His)(6) tag at the C-terminus.	Histidine	123-126	ataxin 1	Homo sapiens	5-13
20463873-2	2010	The simulations were carried out with protonated and deprotonated HC3 histidines His(beta)146, and they sum up to a total length of 5.6 micros.	Histidine	70-80	CYCS pseudogene 24	Homo sapiens	66-69
20159941-1	2010	Substitution of arginine-137 of the vasopressin type 2 receptor (V2R) for histidine (R137H-V2R) leads to nephrogenic diabetes insipidus (NDI), whereas substitution of the same residue to cysteine or leucine (R137C/L-V2R) causes the nephrogenic syndrome of inappropriate antidiuresis (NSIAD).	Histidine	74-83	arginine vasopressin receptor 2	Homo sapiens	36-68
19685013-4	2010	Here, we employed a mutant Abeta (Abeta H13R) in which a histidine residue was replaced by arginine.	Histidine	57-66	amyloid beta precursor protein	Homo sapiens	34-39
19685013-4	2010	Here, we employed a mutant Abeta (Abeta H13R) in which a histidine residue was replaced by arginine.	Histidine	57-66	amyloid beta precursor protein	Homo sapiens	27-32
20145246-8	2010	Finally, two highly conserved intramembrane histidines (His-171 and His-197) within Aph-1, which were recently shown to be important for gamma-secretase activity, are required for efficient binding of substrates.	Histidine	56-59	aph-1 homolog A, gamma-secretase subunit	Homo sapiens	84-89
20045464-8	2010	Hybridization with anti-His(6).Tag antibody indicated that RyR2(1-606)xHis(6) is cleaved from the N-terminus and amino acid sequencing of the proteolytic fragments revealed that digestion occurred after residues 259 and 384, respectively.	Histidine	24-27	ryanodine receptor 2	Homo sapiens	59-63
20145246-8	2010	Finally, two highly conserved intramembrane histidines (His-171 and His-197) within Aph-1, which were recently shown to be important for gamma-secretase activity, are required for efficient binding of substrates.	Histidine	44-54	aph-1 homolog A, gamma-secretase subunit	Homo sapiens	84-89
20145246-8	2010	Finally, two highly conserved intramembrane histidines (His-171 and His-197) within Aph-1, which were recently shown to be important for gamma-secretase activity, are required for efficient binding of substrates.	Histidine	68-71	aph-1 homolog A, gamma-secretase subunit	Homo sapiens	84-89
19995607-6	2010	Here we report the first purification procedure of recombinant fragment of CBP, encompassing the cysteine/histidine-rich domain 3 (CH3) and glutamine-rich (Q) domain of the protein, which is suitable for structural and interaction studies.	Histidine	106-115	CREB binding protein	Homo sapiens	75-78
19697087-6	2010	Treatment of undeveloped ovarian explant cultures with recombinant histidine (His)-RPL10a stimulated the expression of translationally controlled tumor protein (TCTP), heat shock protein 70 (HSP70), and shrimp ovarian peritrophin (SOP) genes, previously shown to be involved in ovarian maturation.	Histidine	67-76	ribosomal protein L10a	Homo sapiens	83-89
19697087-6	2010	Treatment of undeveloped ovarian explant cultures with recombinant histidine (His)-RPL10a stimulated the expression of translationally controlled tumor protein (TCTP), heat shock protein 70 (HSP70), and shrimp ovarian peritrophin (SOP) genes, previously shown to be involved in ovarian maturation.	Histidine	78-81	ribosomal protein L10a	Homo sapiens	83-89
20079503-6	2010	Molecular modeling of AtAP A1 indicated that exposed histidine residues and their interaction with nearby charged groups may explain the pH stability of rAtAP A1.	Histidine	53-62	aspartic proteinase A1	Arabidopsis thaliana	22-29
20368108-6	2010	Firstly RT-PCR and Western blot results showed that the expression of TAP in GES-1 cells was increased after pcDNA3.1/V5-His-TAP1 transfection.	Histidine	121-124	transporter 1, ATP binding cassette subfamily B member	Homo sapiens	125-129
20368109-9	2010	Western blot showed recombinant protein can specificly reacted with anti-human HMGB1 polyclonal antibody and anti-His-Tag polyclonal antibody.The purpose protein was found more than 90% after purified, and can effectively inhibit the production of BAFF, IFN-gamma and TNF-alpha in monocyte which were induced by IC.	Histidine	114-117	interferon gamma	Homo sapiens	254-263
20368109-9	2010	Western blot showed recombinant protein can specificly reacted with anti-human HMGB1 polyclonal antibody and anti-His-Tag polyclonal antibody.The purpose protein was found more than 90% after purified, and can effectively inhibit the production of BAFF, IFN-gamma and TNF-alpha in monocyte which were induced by IC.	Histidine	114-117	tumor necrosis factor	Homo sapiens	268-277
20371992-7	2010	The Raman spectra demonstrate that three histidine residues in the N-terminal region of Abeta provide primary metal binding sites.	Histidine	41-50	amyloid beta precursor protein	Homo sapiens	88-93
20158486-4	2010	D-Lys6-GnRH and [Asn1-Val5]-angiotensin II were modified at their histidine side chain within the peptide, whilst IGF-1 (1-3) was modified at the C-terminal glutamic acid residue.	Histidine	66-75	angiotensinogen	Homo sapiens	28-42
20155951-6	2010	A cluster of histidine and proline residues (His98-Pro99-His100-Pro101-His102) in kappa-casein binds to the C-terminal domain of the protein, where a neighboring conserved arginine residue (Arg97) is found to be important for stabilizing the binding pose.	Histidine	13-22	casein kappa	Bos taurus	82-94
20042613-5	2010	Overexpressed StarD7-I tagged with V5/His in HEPA-1 cells was mainly observed in the mitochondria of cells prepared at low cellular density, but it was distributed in the cytoplasm of high density cells.	Histidine	38-41	START domain containing 7	Mus musculus	14-20
20193843-9	2010	Moreover, we identified mutation of TP53 gene in codon 273; triplet CGT coding Arg was changed to CAG coding His.	Histidine	109-112	tumor protein p53	Homo sapiens	36-40
20126734-1	2010	The specific immobilisation of a histidine-tagged protein, Spi, onto mono-anchored nickel(II)-cyclam functionalised SBA-15 is reported.	Histidine	33-42	chromogranin A	Homo sapiens	59-62
20641976-20	2004	A cyclic peptide, Cys-Asn-Asn-Ser-Lys-Ser-His-Thr-Cys (R832), was identified with phage screening against VCAM-1 (12).	Histidine	42-45	vascular cell adhesion molecule 1	Homo sapiens	106-112
20155941-2	2010	CBS is a pyridoxal-5"-phosphate-dependent heme enzyme with cysteine and histidine axial ligands that catalyzes the condensation of serine and homocysteine to form cystathionine.	Histidine	72-81	cystathionine beta-synthase	Homo sapiens	0-3
19959476-3	2010	Studies of mini-domain models suggest that residue B5 (His in insulin and Thr in IGFs) governs the ambiguity or uniqueness of disulfide pairing.	Histidine	55-58	insulin	Homo sapiens	62-69
19959476-6	2010	In insulin, His(B5) --&gt; Thr markedly destabilizes the hormone (DeltaDeltaG(u) 2.0 +/- 0.2 kcal/mol), impairs chain combination, and blocks cellular secretion of proinsulin.	Histidine	12-15	insulin	Homo sapiens	3-10
19959476-6	2010	In insulin, His(B5) --&gt; Thr markedly destabilizes the hormone (DeltaDeltaG(u) 2.0 +/- 0.2 kcal/mol), impairs chain combination, and blocks cellular secretion of proinsulin.	Histidine	12-15	insulin	Homo sapiens	164-174
19959476-7	2010	The reciprocal IGF-I substitution Thr(B5) --&gt; His (residue 4) specifies a unique structure with native (1)H NMR signature.	Histidine	49-52	insulin like growth factor 1	Homo sapiens	15-20
19959476-13	2010	In contrast, the conservation of His(B5) in insulin highlights its critical role in insulin biosynthesis.	Histidine	33-36	insulin	Homo sapiens	44-51
19959476-13	2010	In contrast, the conservation of His(B5) in insulin highlights its critical role in insulin biosynthesis.	Histidine	33-36	insulin	Homo sapiens	84-91
20038708-9	2010	For stabilization of the expression plasmid, the his4 gene from Saccharomyces cerevisiae was cloned into the expression vector used and the constructs were transferred to histidine auxotrophic P. pastoris strain GS115.	Histidine	171-180	trifunctional histidinol dehydrogenase/phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase	Saccharomyces cerevisiae S288C	49-53
19723023-8	2010	With detraining in the HI group, CD34+ cells declined 44 %, and the percentage change in CD34+/VEGFR2+ cells was positively correlated with the change in FBF response to reactive hyperaemia.	Histidine	23-25	CD34 molecule	Homo sapiens	33-37
19966022-6	2010	Furthermore, we have expressed Bdh2p with a histidine tag and have shown it to be inactive toward 2,3-butanediol.	Histidine	44-53	putative dehydrogenase BDH2	Saccharomyces cerevisiae S288C	31-36
19723023-8	2010	With detraining in the HI group, CD34+ cells declined 44 %, and the percentage change in CD34+/VEGFR2+ cells was positively correlated with the change in FBF response to reactive hyperaemia.	Histidine	23-25	CD34 molecule	Homo sapiens	89-93
19995914-7	2010	These Cox1 intermediates form normally in cells defective in heme a biosynthesis or in cox1 mutant strains with heme a axial His mutations.	Histidine	125-128	cytochrome c oxidase subunit 1	Saccharomyces cerevisiae S288C	6-10
19995914-7	2010	These Cox1 intermediates form normally in cells defective in heme a biosynthesis or in cox1 mutant strains with heme a axial His mutations.	Histidine	125-128	cytochrome c oxidase subunit 1	Saccharomyces cerevisiae S288C	87-91
19920148-3	2010	One such mutation that changes an aspartic residue to histidine at position 307 in CASQ2 has been linked to catecholaminergic polymorphic ventricular tachycardia.	Histidine	54-63	calsequestrin 2	Mus musculus	83-88
19875381-5	2010	We further characterized a novel ADP-dependent HSP90 interaction with the cysteine- and histidine-rich domain (CHORD)-containing protein CHORDC1.	Histidine	88-97	cysteine and histidine rich domain containing 1	Homo sapiens	137-144
19880525-3	2010	The C-terminal activation domain of HIF-1 alpha has been shown to interact with cysteine/histidine-rich region 1 (CH1) of the coactivator CBP/p300 in a hypoxia-dependent manner.	Histidine	89-98	hypoxia inducible factor 1 subunit alpha	Homo sapiens	36-47
20041650-2	2010	We report a stabilized alpha-helix designed to target the binding interface between the C-terminal transactivation domain (C-TAD) of hypoxia-inducible factor 1alpha (HIF-1alpha) and cysteine-histidine rich region (CH1) of transcriptional coactivator CBP/p300.	Histidine	191-200	hypoxia inducible factor 1 subunit alpha	Homo sapiens	133-164
20041650-2	2010	We report a stabilized alpha-helix designed to target the binding interface between the C-terminal transactivation domain (C-TAD) of hypoxia-inducible factor 1alpha (HIF-1alpha) and cysteine-histidine rich region (CH1) of transcriptional coactivator CBP/p300.	Histidine	191-200	CREB binding protein	Homo sapiens	250-258
19880525-3	2010	The C-terminal activation domain of HIF-1 alpha has been shown to interact with cysteine/histidine-rich region 1 (CH1) of the coactivator CBP/p300 in a hypoxia-dependent manner.	Histidine	89-98	CREB binding protein	Homo sapiens	138-146
19950924-8	2010	Sequence analysis of the DHFR superfamily revealed that the His residue is the major amino acid component at this position and is found mostly in pathogenic bacterial DHFRs.	Histidine	60-63	dihydrofolate reductase	Escherichia coli	25-29
19850925-11	2010	In order of increasing affinity, SCR-16/20, SCR-6/8 (His-402), and SCR-6/8 (Tyr-402) fragments bound to CRP.	Histidine	53-56	C-reactive protein	Homo sapiens	104-107
19900404-2	2010	The hMIP fusion protein, with a poly-His-tag (6x His), was obtained by cloning the coding region of hMIP cDNA into the pET-28a expression vector, which was then used to transform Escherichia coli BL21 (DE3) pLysS.	Histidine	37-40	major intrinsic protein of lens fiber	Homo sapiens	4-8
19947643-5	2010	There are two ways in which the undissociated form of a bis-chelated complex can interact with transferrin, one "specific" when the carrier possesses a carboxylate group and behaves like a synergistic anion, and another "non-specific" when an imidazole nitrogen of a histidine residue from hTf replaces an equatorially coordinated water molecule giving rise to a ternary species with cis-octahedral geometry and cis-VO(carrier)(2)(hTf) stoichiometry.	Histidine	267-276	transferrin	Homo sapiens	95-106
19892707-6	2010	Further analyses revealed that some known CaSR agonists such as Ca(2+), protamine, polylysine, L-histidine, and cinacalcet (a calcium-mimetic drug) also elicit the kokumi taste and that the CaSR-specific antagonist, NPS-2143, significantly suppresses the kokumi taste.	Histidine	95-106	calcium sensing receptor	Homo sapiens	42-46
19892707-6	2010	Further analyses revealed that some known CaSR agonists such as Ca(2+), protamine, polylysine, L-histidine, and cinacalcet (a calcium-mimetic drug) also elicit the kokumi taste and that the CaSR-specific antagonist, NPS-2143, significantly suppresses the kokumi taste.	Histidine	95-106	calcium sensing receptor	Homo sapiens	190-194
19580831-4	2010	Monoclonal antibodies conjugated DBM (MAbs-DBM) could bind more His-BMP(2) than DBM and achieved controlled release in vitro.	Histidine	64-67	bone morphogenetic protein 2	Mus musculus	68-74
19580831-5	2010	The alkaline phophatase (AP) activity of C2C12 cells on MAbs-DBM indicated that His-BMP(2) retained on MAbs-DBM preserved the function to induce osteogenic differentiation.	Histidine	80-83	bone morphogenetic protein 2	Mus musculus	84-90
19580831-6	2010	His-BMP(2)/MAbs-DBM induced more ectopic bone formation (AP activity assay and histochemistry stain) than control group after subcutaneous implantation.	Histidine	0-3	bone morphogenetic protein 2	Mus musculus	4-10
19566844-14	2010	Reverse transcription-polymerase chain reaction analysis revealed that the aortic expression of angiotensin-converting enzyme mRNA was suppressed by chronic treatment with L-histidine.	Histidine	172-183	angiotensin I converting enzyme	Rattus norvegicus	96-125
19928803-10	2010	Through the detection of a Lim-2-OOH adduct bound at the first histidine (of two) of angiotensin I, it was confirmed that hydroperoxides have the potential to form specific antigens in contact allergy.	Histidine	63-72	lens intrinsic membrane protein 2	Homo sapiens	27-32
19928803-10	2010	Through the detection of a Lim-2-OOH adduct bound at the first histidine (of two) of angiotensin I, it was confirmed that hydroperoxides have the potential to form specific antigens in contact allergy.	Histidine	63-72	angiotensinogen	Homo sapiens	85-98
19786581-8	2010	Nevertheless, GS115 (his4) cells in flask culture secreted 3.5 mg/L of a histidine-tagged ATF-saporin chimera showing an IC(50) of 6 x 10(-11) M against U937 cells, thus demonstrating the suitability of this expression platform for secretion of toxic saporin-based chimeras.	Histidine	73-82	glial cell derived neurotrophic factor	Homo sapiens	90-93
19720079-1	2010	Histidine triad nucleotide binding protein (HINT) represents the most ancient and widespread branches in the histidine triad superfamily.	Histidine	109-118	histidine triad nucleotide binding protein 1	Homo sapiens	44-48
20946858-4	2010	Herein, we describe the analysis of the phosphorylation and dephosphorylation of histidine residues by NDPK and PHPT-1.	Histidine	81-90	phosphohistidine phosphatase 1	Homo sapiens	112-118
20061603-2	2010	While the mechanism(s) that modulate this toxicity are still widely debated, it has previously been demonstrated that modifications to the three histidine residues (6, 13, and 14) of Abeta are able to modulate the toxicity.	Histidine	145-154	amyloid beta precursor protein	Homo sapiens	183-188
19883942-2	2010	Outside this region, hPrP possesses two additional copper binding sites, localized at His-96 and His-111 in the so called "amylodogenic" or neurotoxic region (residues 91-126).	Histidine	86-89	prion protein	Homo sapiens	21-25
19883942-2	2010	Outside this region, hPrP possesses two additional copper binding sites, localized at His-96 and His-111 in the so called "amylodogenic" or neurotoxic region (residues 91-126).	Histidine	97-100	prion protein	Homo sapiens	21-25
19883942-7	2010	We found that the two prion proteins exhibited different copper and nickel preferences with the favoured metal binding sites localized at opposite His: His-110 for ChPrP, and His-111 for hPrP.	Histidine	152-155	prion protein	Homo sapiens	165-169
19883942-7	2010	We found that the two prion proteins exhibited different copper and nickel preferences with the favoured metal binding sites localized at opposite His: His-110 for ChPrP, and His-111 for hPrP.	Histidine	152-155	prion protein	Homo sapiens	165-169
19801377-5	2010	Palmitoyl acyltransferases DHHC5, DHHC6, and DHHC8 appear to be S-acylated on three cysteine residues within a novel CCX(7-13)C(S/T) motif downstream of a conserved Asp-His-His-Cys cysteine-rich domain, which may be a potential mechanism for regulating acyltransferase specificity and/or activity.	Histidine	169-172	zinc finger DHHC-type palmitoyltransferase 5	Homo sapiens	27-32
19801377-5	2010	Palmitoyl acyltransferases DHHC5, DHHC6, and DHHC8 appear to be S-acylated on three cysteine residues within a novel CCX(7-13)C(S/T) motif downstream of a conserved Asp-His-His-Cys cysteine-rich domain, which may be a potential mechanism for regulating acyltransferase specificity and/or activity.	Histidine	169-172	zinc finger DHHC-type palmitoyltransferase 6	Homo sapiens	34-39
19702542-0	2009	Effects of histidine-tag on recombinant human cytochrome P450 3A5 catalytic activity in reconstitution systems.	Histidine	11-20	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	46-65
19536822-5	2009	Correlation between the structure of the heme and its ligands for heme with His-Met axial ligation and ligand-field parameters, as derived from a large series of cytochrome c variants, show, however, that for such a combination of axial ligands there is no clear-cut difference between the large g(max) and the "small g-anisotropy" cases as a result of the relative Met-His arrangements.	Histidine	76-79	cytochrome c, somatic	Homo sapiens	162-174
19536822-5	2009	Correlation between the structure of the heme and its ligands for heme with His-Met axial ligation and ligand-field parameters, as derived from a large series of cytochrome c variants, show, however, that for such a combination of axial ligands there is no clear-cut difference between the large g(max) and the "small g-anisotropy" cases as a result of the relative Met-His arrangements.	Histidine	370-373	cytochrome c, somatic	Homo sapiens	162-174
19958228-3	2009	MATERIALS &amp; METHODS: VIP was conjugated to tiopronin-capped silver nanoparticles of a narrow size distribution, by means of proper linkers, to obtain VIP functionalized silver nanoparticles with two different VIP orientations (Ag-tiopronin-PEG-succinic-[His]VIP and Ag-tiopronin-PEG-VIP[His]).	Histidine	258-261	vasoactive intestinal polypeptide	Mus musculus	25-28
19857899-1	2009	CopH is a periplasmic copper-binding protein from Cupriavidus metallidurans CH34 that contains two histidine residues.	Histidine	99-108	CopH protein	Cupriavidus metallidurans CH34	0-4
19834685-4	2009	[Arg(A0)]-HI induced a marked increase in the phosphotyrosine content of endosomal insulin receptor, coinciding with a more sustained endosomal association of growth factor receptor-bound protein 14 (GRB14), and a higher and prolonged activation of mitogen-activated protein kinase pathways.	Histidine	9-12	growth factor receptor bound protein 14	Homo sapiens	159-198
19834685-4	2009	[Arg(A0)]-HI induced a marked increase in the phosphotyrosine content of endosomal insulin receptor, coinciding with a more sustained endosomal association of growth factor receptor-bound protein 14 (GRB14), and a higher and prolonged activation of mitogen-activated protein kinase pathways.	Histidine	9-12	growth factor receptor bound protein 14	Homo sapiens	200-205
19834685-9	2009	The endosomal conversion of [Arg(A0)]-HI into human insulin might extend the insulin receptor signalling at this locus.	Histidine	37-40	insulin	Homo sapiens	52-59
19780898-2	2009	We found that a protein containing Asp-His-His-Cys (DHHC) domain, alcadein and APP interacting DHHC protein (AID)/DHHC-12, strongly inhibited APP metabolism, including amyloid beta-protein (Abeta) generation.	Histidine	39-42	amyloid beta precursor protein	Homo sapiens	190-195
19455640-0	2009	Methionine, tryptophan, and histidine oxidation in a model protein, PTH: mechanisms and stabilization.	Histidine	28-37	parathyroid hormone	Homo sapiens	68-71
19455640-5	2009	Oxidation of the His residue in PTH occurred when copper was used instead of iron.	Histidine	17-20	parathyroid hormone	Homo sapiens	32-35
19958228-3	2009	MATERIALS &amp; METHODS: VIP was conjugated to tiopronin-capped silver nanoparticles of a narrow size distribution, by means of proper linkers, to obtain VIP functionalized silver nanoparticles with two different VIP orientations (Ag-tiopronin-PEG-succinic-[His]VIP and Ag-tiopronin-PEG-VIP[His]).	Histidine	291-294	vasoactive intestinal polypeptide	Mus musculus	25-28
19958228-7	2009	RESULTS: Two different types of VIP-functionalized silver nanoparticles were obtained; both expose the C-terminal part of the neuropeptide, but in the first type VIP is attached to silver nanoparticle through its free amine terminus (Ag-tiopronin-PEG-succinic-[His]VIP), while in the second type, VIP N-terminus remains free (Ag-tiopronin-PEG-VIP[His]).	Histidine	261-264	vasoactive intestinal polypeptide	Mus musculus	32-35
19958228-7	2009	RESULTS: Two different types of VIP-functionalized silver nanoparticles were obtained; both expose the C-terminal part of the neuropeptide, but in the first type VIP is attached to silver nanoparticle through its free amine terminus (Ag-tiopronin-PEG-succinic-[His]VIP), while in the second type, VIP N-terminus remains free (Ag-tiopronin-PEG-VIP[His]).	Histidine	347-350	vasoactive intestinal polypeptide	Mus musculus	32-35
19810698-0	2009	Analysis of the dynamics of assembly and structural impact for a histidine tagged FGF1-1.5 nm Au nanoparticle bioconjugate.	Histidine	65-74	fibroblast growth factor 1	Homo sapiens	82-86
19923747-3	2009	A recombinant His-tagged portion of the extracellular domain of Stk1 containing three PASTA subunits has been crystallized using zinc sulfate as a crystallizing agent.	Histidine	14-17	cyclin dependent kinase 7	Homo sapiens	64-68
19923747-3	2009	A recombinant His-tagged portion of the extracellular domain of Stk1 containing three PASTA subunits has been crystallized using zinc sulfate as a crystallizing agent.	Histidine	14-17	solute carrier family 45 member 1	Homo sapiens	86-91
19810698-2	2009	In this study, the assembly of a 1.5 nm CAAKA passivated gold nanoparticle (AuNP) onto FGF1 (human acidic fibroblast growth factor) using an amino terminal His(6) tag is analyzed.	Histidine	156-159	fibroblast growth factor 1	Homo sapiens	87-91
20149311-3	2009	TRAIL-mediated apoptosis of FLS was quantified by disruption of mitochondrial transmembrane potential (DeltaPsim), Leu-Glu-His-Asp (IETD) ase activity and DNA degradation.	Histidine	123-126	TNF superfamily member 10	Homo sapiens	0-5
19823671-3	2009	METHODOLOGY/PRINCIPAL FINDINGS: A novel site-specific labeling method is presented that targets a FRET acceptor, Cy3NTA to 10-residue histidine (His) tags engineered into RyR1.	Histidine	134-143	ryanodine receptor 1	Homo sapiens	171-175
19735445-0	2009	Cyclo(His-Pro) up-regulates heme oxygenase 1 via activation of Nrf2-ARE signalling.	Histidine	6-9	NFE2 like bZIP transcription factor 2	Rattus norvegicus	63-67
19735445-8	2009	These results suggest that cyclo(His-Pro), acting as a selective activator of the brain modulable Nrf2 pathway, may be a promising candidate as neuroprotective agent that act through induction of phase II genes.	Histidine	33-36	NFE2 like bZIP transcription factor 2	Rattus norvegicus	98-102
19761259-10	2009	Interaction of A52-tagged wild-type N-half or DeltaF508/N-half CFTR with histidine-tagged C-half CFTR was then followed by nickel-chelate chromatography.	Histidine	73-82	CF transmembrane conductance regulator	Homo sapiens	63-67
19761259-10	2009	Interaction of A52-tagged wild-type N-half or DeltaF508/N-half CFTR with histidine-tagged C-half CFTR was then followed by nickel-chelate chromatography.	Histidine	73-82	CF transmembrane conductance regulator	Homo sapiens	97-101
19761259-11	2009	Coexpression of A52-tagged wild-type N-half or DeltaF508/N-half CFTR with histidine-tagged C-half CFTR resulted in the wild-type N-half CFTR but not DeltaF508/N-half CFTR protein being retained on the column.	Histidine	74-83	CF transmembrane conductance regulator	Homo sapiens	98-102
19761259-11	2009	Coexpression of A52-tagged wild-type N-half or DeltaF508/N-half CFTR with histidine-tagged C-half CFTR resulted in the wild-type N-half CFTR but not DeltaF508/N-half CFTR protein being retained on the column.	Histidine	74-83	CF transmembrane conductance regulator	Homo sapiens	98-102
19761259-11	2009	Coexpression of A52-tagged wild-type N-half or DeltaF508/N-half CFTR with histidine-tagged C-half CFTR resulted in the wild-type N-half CFTR but not DeltaF508/N-half CFTR protein being retained on the column.	Histidine	74-83	CF transmembrane conductance regulator	Homo sapiens	98-102
19823671-3	2009	METHODOLOGY/PRINCIPAL FINDINGS: A novel site-specific labeling method is presented that targets a FRET acceptor, Cy3NTA to 10-residue histidine (His) tags engineered into RyR1.	Histidine	145-148	ryanodine receptor 1	Homo sapiens	171-175
19658411-4	2009	Here we show that the 221 cm(-1) mode of the photoproduct of iNOS(P420) does not exhibit any H(2)O-D(2)O solvent isotope shift such as that found in the iron-histidine stretching mode of myoglobin, indicating that the proximal ligand of iNOS(P420) is not a histidine.	Histidine	158-167	nitric oxide synthase 2	Homo sapiens	61-65
19799668-6	2009	However, the pre-intake of carnosine or histidine significantly alleviated acetaminophen-induced oxidative stress by increasing GSH content, decreasing MDA, ROS, and GSSG formations, and retaining activity of GPX, catalase, and SOD in liver (P &lt; 0.05).	Histidine	40-49	catalase	Mus musculus	214-222
19608745-2	2009	The crystal structure of a mixture of glycoforms of myeloperoxidase (MPO) purified from granules of human leukocytes prompted us to revise the orientation of this asparagine and the protonation status of the proximal histidine.	Histidine	217-226	myeloperoxidase	Homo sapiens	52-67
19608745-2	2009	The crystal structure of a mixture of glycoforms of myeloperoxidase (MPO) purified from granules of human leukocytes prompted us to revise the orientation of this asparagine and the protonation status of the proximal histidine.	Histidine	217-226	myeloperoxidase	Homo sapiens	69-72
19456318-3	2009	A nucleotide substitution of T to A resulting in an amino acid substitution of leucine to histidine (p.Leu2153His) was identified in a highly conserved residue in the C1 domain of factor VIII.	Histidine	90-99	coagulation factor VIII	Bos taurus	180-191
20011642-0	2009	Expression and purification of recombinant human coagulation factor VII fused to a histidine tag using Gateway technology.	Histidine	83-92	coagulation factor VII	Homo sapiens	49-71
19558415-3	2009	Here, we report on a panel of tripeptide analogs consisting of a modified alpha-MSH core His(6)-d-Phe(7)-Arg(8), which contained different N-capping groups, C-terminal modifications, or arginine mimics.	Histidine	89-92	proopiomelanocortin	Homo sapiens	74-83
19658411-4	2009	Here we show that the 221 cm(-1) mode of the photoproduct of iNOS(P420) does not exhibit any H(2)O-D(2)O solvent isotope shift such as that found in the iron-histidine stretching mode of myoglobin, indicating that the proximal ligand of iNOS(P420) is not a histidine.	Histidine	158-167	nitric oxide synthase 2	Homo sapiens	61-70
19658411-4	2009	Here we show that the 221 cm(-1) mode of the photoproduct of iNOS(P420) does not exhibit any H(2)O-D(2)O solvent isotope shift such as that found in the iron-histidine stretching mode of myoglobin, indicating that the proximal ligand of iNOS(P420) is not a histidine.	Histidine	257-266	nitric oxide synthase 2	Homo sapiens	61-65
19658411-4	2009	Here we show that the 221 cm(-1) mode of the photoproduct of iNOS(P420) does not exhibit any H(2)O-D(2)O solvent isotope shift such as that found in the iron-histidine stretching mode of myoglobin, indicating that the proximal ligand of iNOS(P420) is not a histidine.	Histidine	257-266	nitric oxide synthase 2	Homo sapiens	61-70
19658411-7	2009	Together the data support the scenario that iNOS(P420) is inactivated by protonation of the native proximal thiolate ligand to a neutral thiol, instead of by ligand switching to a histidine, as prior studies have suggested.	Histidine	180-189	nitric oxide synthase 2	Homo sapiens	44-48
19479888-1	2009	The fragile histidine triad gene (human FHIT, mouse Fhit) has been shown to act as a tumor suppressor gene.	Histidine	12-21	fragile histidine triad gene	Mus musculus	52-56
19721088-7	2009	For system II, the CcsB and CcsA proteins form a cytochrome c synthetase complex which specifically channels heme to an external heme binding domain; in this conserved tryptophan-rich "WWD domain" (in CcsA), the heme is maintained in the reduced state by two external histidines and then ligated to the CXXCH motif.	Histidine	268-278	cytochrome c, somatic	Homo sapiens	49-61
19535453-5	2009	In the CD4-bound conformation, the highly conserved histidine 66 is located between the receptor-binding and gp41-interactive surfaces of gp120.	Histidine	52-61	CD4 molecule	Homo sapiens	7-10
19496992-5	2009	The appearance of phosphorylated form of p38 MAPKs and JNK1/2 was inhibited by the singlet oxygen scavenger l-histidine.	Histidine	108-119	mitogen-activated protein kinase 14	Homo sapiens	41-44
19496992-5	2009	The appearance of phosphorylated form of p38 MAPKs and JNK1/2 was inhibited by the singlet oxygen scavenger l-histidine.	Histidine	108-119	mitogen-activated protein kinase 8	Homo sapiens	55-61
19608714-7	2009	Mutation of the conserved His residue in the NtETR1 H box eliminated phosphorylation and altered the effect of Ntetr1-1 on reporter gene activity.	Histidine	26-29	ethylene receptor	Nicotiana tabacum	45-51
19608714-7	2009	Mutation of the conserved His residue in the NtETR1 H box eliminated phosphorylation and altered the effect of Ntetr1-1 on reporter gene activity.	Histidine	26-29	ethylene receptor	Nicotiana tabacum	111-119
19539805-1	2009	Substances K-48 and HI-6, oxime-type acetylcholinesterase (AChE) reactivators, were tested for their potential to inhibit the activities of human liver microsomal cytochromes P450 (CYP).	Histidine	20-22	acetylcholinesterase (Cartwright blood group)	Homo sapiens	59-63
20021932-1	2009	OBJECTIVES: To investigate the impact of AAV-encoding NT4-TAT-His-PR39 fusion gene expression on HIF-1alpha level in ECV304 cultured under hypoxic condition (1%O(2)) and on angiogenesis in hypoxic chick embryo.	Histidine	62-65	hypoxia inducible factor 1 alpha subunit	Gallus gallus	97-107
19515935-5	2009	Although the histidine-tagged CTD (hCTD) was monomeric in solution, hCTD bound cooperatively to three of the recombination substrates (attB, attL and attR).	Histidine	13-22	CTD	Homo sapiens	30-33
19515935-5	2009	Although the histidine-tagged CTD (hCTD) was monomeric in solution, hCTD bound cooperatively to three of the recombination substrates (attB, attL and attR).	Histidine	13-22	CTD	Homo sapiens	35-39
19515935-5	2009	Although the histidine-tagged CTD (hCTD) was monomeric in solution, hCTD bound cooperatively to three of the recombination substrates (attB, attL and attR).	Histidine	13-22	CTD	Homo sapiens	68-72
19541676-2	2009	SCA1 is unique in which the polyQ in the disease protein, ataxin1, often contains a few His residues that appear to block toxicity.	Histidine	88-91	ataxin 1	Homo sapiens	0-4
19541676-2	2009	SCA1 is unique in which the polyQ in the disease protein, ataxin1, often contains a few His residues that appear to block toxicity.	Histidine	88-91	ataxin 1	Homo sapiens	58-65
19489740-7	2009	Its lysosomal localization was confirmed using immunofluorescence with a C-terminally His-tagged NCU-G1 and the lysosomal marker LAMP-1 (lysosome-associated membrane protein-1) as a reference, and by subcellular fractionation of mouse liver after a tyloxapol-induced density shift of the lysosomal fraction using an anti-NCU-G1 antiserum.	Histidine	86-89	glycosylated lysosomal membrane protein	Mus musculus	97-103
19215234-6	2009	The histamine H(1) receptor antagonist pyrilamine (1 microg/site) abolished the ameliorative effects of histidine on working memory deficits, whereas both pyrilamine and the H(2) receptor antagonist cimetidine (0.5 microg/site) abolished the effect of histidine on reference memory.	Histidine	104-113	histamine receptor H 1	Rattus norvegicus	4-27
19357133-6	2009	Localization studies revealed plasma membrane, cytosolic, microsomal, and mitochondrial localization of endogenous and His-tagged SLC44A1.	Histidine	119-122	solute carrier family 44, member 1	Mus musculus	130-137
19583817-6	2009	Western blotting of His-tag H2BFWT revealed a difference at the translational level between -9T and the wild-type -9C in the absence of change at the transcriptional level.	Histidine	20-23	H2B.W histone 1	Homo sapiens	28-34
19615751-6	2009	Using spectroscopic techniques we find that the PrP region encompassing histidines 96 and 111 can bind a Cu(I) ion in a site comprising His 96, His 111, Met 109 and Met 112.	Histidine	72-82	prion protein	Homo sapiens	48-51
19615751-6	2009	Using spectroscopic techniques we find that the PrP region encompassing histidines 96 and 111 can bind a Cu(I) ion in a site comprising His 96, His 111, Met 109 and Met 112.	Histidine	136-139	prion protein	Homo sapiens	48-51
19300994-6	2009	An ArgR-derivative carrying a carboxy-terminal His-tag was made and this was demonstrated to localize even in an E. coli mutant devoid of the twin-arginine translocation (Tat) pathway in the periplasm.	Histidine	47-50	arginine repressor	Escherichia coli	3-7
19469484-5	2009	The SBi279 binding site on Ca(2+)-S100B overlaps the SBi132 and SBi523 sites and contacts residues in both loop 2 (Ser-41, His-42, Phe-43, Leu-44, and Glu-45) and helix 4 (Ile-80, Ala-83, Cys-84, Phe-87, and Phe-88).	Histidine	123-126	S100 calcium binding protein B	Homo sapiens	34-39
19369342-5	2009	Moreover, a Cys-plus-His-rich region within RTA is important for RTA-mediated degradation of Hey1.	Histidine	21-24	hes related family bHLH transcription factor with YRPW motif 1	Homo sapiens	93-97
19515425-0	2009	Histidine analogues of oxytocin and vasopressin as efficient ligands for Zn2+ ions--potentiometric and NMR studies.	Histidine	0-9	arginine vasopressin	Homo sapiens	36-47
19515425-1	2009	We have characterized the interaction between the Zn(2+) ions and the histidine analogues of oxytocin and arginine-vasopressin.	Histidine	70-79	arginine vasopressin	Homo sapiens	115-126
19652522-6	2009	The new protocol is based on column purification of His-tagged hsp70 protein produced by E. coli with the modified medium, followed by endotoxin removal by Triton X-114 extraction.	Histidine	52-55	heat shock protein 1B	Mus musculus	63-68
19482919-5	2009	Oxidative protection resulting from AnnAt1 overexpression could be due to the low level of intrinsic peroxidase activity exhibited by this protein in vitro, previously linked to a conserved histidine residue found in a peroxidase-like motif.	Histidine	190-199	annexin 1	Arabidopsis thaliana	36-42
19482919-5	2009	Oxidative protection resulting from AnnAt1 overexpression could be due to the low level of intrinsic peroxidase activity exhibited by this protein in vitro, previously linked to a conserved histidine residue found in a peroxidase-like motif.	Histidine	190-199	peroxidase	Arabidopsis thaliana	101-111
19482919-5	2009	Oxidative protection resulting from AnnAt1 overexpression could be due to the low level of intrinsic peroxidase activity exhibited by this protein in vitro, previously linked to a conserved histidine residue found in a peroxidase-like motif.	Histidine	190-199	peroxidase	Arabidopsis thaliana	219-229
19329426-6	2009	Furthermore, by replacing the anionic C-terminal tail residues that extend the CBS module with histidines, the transport of OpuA became pH-dependent, presumably by additional charge interactions of the histidine residues with the membrane.	Histidine	95-105	cystathionine beta-synthase	Homo sapiens	79-82
19338344-8	2009	Electron paramagnetic resonance studies (EPR) with Abeta His/Ala analogues suggest a dynamic view of the tetragonal Cu(2+) complex, with axial as well as equatorial coordination of imidazole nitrogens creating an ensemble of coordination geometries in exchange between each other.	Histidine	57-60	amyloid beta precursor protein	Homo sapiens	51-56
19415897-1	2009	Mutagenesis data suggest that BNIP3 transmembrane domain dimerization depends critically on hydrogen bonding between His 173 and Ser 172, but a recent structural analysis indicates that these residues adopt multiple conformations and are not always hydrogen bonded.	Histidine	117-120	BCL2 interacting protein 3	Homo sapiens	30-35
18373731-3	2009	Here, we addressed this issue and found that cyclo(His-Pro) triggered nuclear accumulation of NF-E2-related factor-2 (Nrf2), a transcription factor that up-regulates antioxidant-/electrophile-responsive element (ARE-EpRE)-related genes, in PC12 cells.	Histidine	51-54	NFE2 like bZIP transcription factor 2	Rattus norvegicus	94-116
18373731-3	2009	Here, we addressed this issue and found that cyclo(His-Pro) triggered nuclear accumulation of NF-E2-related factor-2 (Nrf2), a transcription factor that up-regulates antioxidant-/electrophile-responsive element (ARE-EpRE)-related genes, in PC12 cells.	Histidine	51-54	NFE2 like bZIP transcription factor 2	Rattus norvegicus	118-122
19386804-6	2009	Optical absorption and electron paramagnetic resonance analysis indicate that AIR12 binds a single, highly axial low-spin heme, likely coordinated by methionine-91 and histidine-76, which are strongly conserved in AIR12 sequences.	Histidine	168-177	plasma membrane ascorbate-reducible b-type cytochrome family protein	Glycine max	78-83
19329426-6	2009	Furthermore, by replacing the anionic C-terminal tail residues that extend the CBS module with histidines, the transport of OpuA became pH-dependent, presumably by additional charge interactions of the histidine residues with the membrane.	Histidine	95-104	cystathionine beta-synthase	Homo sapiens	79-82
19232736-8	2009	EXAFS studies on C-424 CBS are consistent with the presence of two axial N/O low Z scatters with only one being a rigid unit of a histidine residue while the other could be a solvent molecule, an oxygen atom from the peptide backbone or a side chain nitrogen.	Histidine	130-139	cystathionine beta-synthase	Homo sapiens	23-26
19433218-6	2009	In the present study, we cloned and purified both N- and C-terminal His-tagged rat galactokinase.	Histidine	68-71	galactokinase 1	Rattus norvegicus	83-96
19285990-5	2009	Incorporation of a six-histidine (His(6)) peptide into the C-terminus of the 41s fiber protein resulted in markedly increased Ad5F41s6H infectivity in 293AR cells, which express a membrane-anchored scFv against the C-terminal oligohistidine tag, as compared to the Ad5F41s vector and the parental 293 cells.	Histidine	23-32	immunglobulin heavy chain variable region	Homo sapiens	198-202
19285990-5	2009	Incorporation of a six-histidine (His(6)) peptide into the C-terminus of the 41s fiber protein resulted in markedly increased Ad5F41s6H infectivity in 293AR cells, which express a membrane-anchored scFv against the C-terminal oligohistidine tag, as compared to the Ad5F41s vector and the parental 293 cells.	Histidine	34-37	immunglobulin heavy chain variable region	Homo sapiens	198-202
19285990-6	2009	These data suggested that a 41s-fiber-incorporated His(6) tag could serve for attachment of an adapter protein designed to guide Ad5F41s6H infection in a c-erbB2-specific manner.	Histidine	51-54	erb-b2 receptor tyrosine kinase 2	Homo sapiens	154-161
19285990-8	2009	Thus, Ad5 fiber replacement by a His(6)-tagged 41s fiber coupled with virus targeting mediated by an scDb adapter represents a promising strategy to confer Ad5 vector tropism for c-erbB2-positive cancer cells.	Histidine	33-36	erb-b2 receptor tyrosine kinase 2	Homo sapiens	179-186
19273554-5	2009	Using site-directed mutagenesis, we identified histidine 337 and histidine 371 in SCR 6 as important for binding to fHbp.	Histidine	65-74	scruffy	Mus musculus	82-85
19318355-5	2009	Alignment of all angiopoietin family members revealed that a sequence similar to ANGPTL4 SE1 was present only in ANGPTL3, corresponding to amino acids Glu(32)-His(55).	Histidine	159-162	angiopoietin-like 3	Mus musculus	113-120
19146426-7	2009	The insulin binding region is composed of the same amino acids in amyloidogenic human IAPP and soluble rat IAPP (with the sole exception of His/Arg-18), implying the same binding mode for both hormones.	Histidine	140-143	insulin	Homo sapiens	4-11
19211747-5	2009	Histidine 66 is located within the gp41-interactive inner domain of gp120 and, in other studies, has been shown to decrease the sampling of the CD4-bound conformation by unliganded gp120.	Histidine	0-9	CD4 molecule	Homo sapiens	144-147
19384991-0	2009	Contribution of individual histidines to the global stability of human prolactin.	Histidine	27-37	prolactin	Homo sapiens	71-80
19384991-4	2009	hPRL contains nine histidines, compared with hGH"s three, and they are likely responsible for hPRL"s pH-dependent behavior.	Histidine	19-29	prolactin	Homo sapiens	0-4
19384991-5	2009	We have systematically mutated each of hPRL"s histidines to alanine and measured the effect on pH-dependent global stability.	Histidine	46-56	prolactin	Homo sapiens	39-43
19384991-7	2009	Changes in the overall pH dependence to hPRL global stability can be rationalized according to the predominant structural interactions of individual histidines in the hPRL tertiary structure.	Histidine	149-159	prolactin	Homo sapiens	40-44
19384991-7	2009	Changes in the overall pH dependence to hPRL global stability can be rationalized according to the predominant structural interactions of individual histidines in the hPRL tertiary structure.	Histidine	149-159	prolactin	Homo sapiens	167-171
19384991-9	2009	Finally, by comparing the structural locations of hPRL"s nine histidines with their homologous residues in hGH, we speculate on the evolutionary role of replacing structurally stabilizing residues with histidine to introduce pH dependence to cytokine function.	Histidine	62-72	prolactin	Homo sapiens	50-54
19384991-9	2009	Finally, by comparing the structural locations of hPRL"s nine histidines with their homologous residues in hGH, we speculate on the evolutionary role of replacing structurally stabilizing residues with histidine to introduce pH dependence to cytokine function.	Histidine	62-71	prolactin	Homo sapiens	50-54
19270403-1	2009	SK(66)-his, a novel glycine-rich peptide derived from the CG13551 gene of Drosophila, was directly expressed in Escherichia coli with the help of the glucose effect of the lac repressor and efficiently purified in high yield (10.063 mg/l).	Histidine	7-10	uncharacterized protein	Drosophila melanogaster	58-65
19217736-7	2009	It was further found that there was a slight tendency for samples containing inorganic salts or histidine to be underestimated in the NIR measurements.	Histidine	96-105	NOC2 like nucleolar associated transcriptional repressor	Homo sapiens	134-137
19260709-5	2009	An X-ray crystal structure of R388A Src revealed the surprising finding that a histidine residue of the N-terminus of a symmetry-related kinase inserts into the active site of the adjacent Src and mimics the hydrogen-bonding pattern seen in wild-type protein tyrosine kinases.	Histidine	79-88	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	36-39
19260709-5	2009	An X-ray crystal structure of R388A Src revealed the surprising finding that a histidine residue of the N-terminus of a symmetry-related kinase inserts into the active site of the adjacent Src and mimics the hydrogen-bonding pattern seen in wild-type protein tyrosine kinases.	Histidine	79-88	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	189-192
19331830-7	2009	Val(24) was required for p53-independent growth suppression whereas multiple residues (Val(24), Thr(31), Ala(41) and His(60)) enabled p14ARF to block or reverse the inherent chromosomal instability of p53-null MEFs.	Histidine	117-120	cyclin dependent kinase inhibitor 2A	Homo sapiens	134-140
19047760-6	2009	Histidine-21 and cysteine-111 of rat H-Rev107 were presumed to form a catalytic dyad based on database analysis, and their single mutants were totally inactive.	Histidine	0-9	phospholipase A and acyltransferase 3	Rattus norvegicus	37-45
19289435-1	2009	UNLABELLED: The aim of this study was to determine the effects of assisted coordination by amino acids such as histidine and glutamic acid on the function of (99m)Tc-labeled gastrin peptide-hydrazinonicotinamide (HYNIC) conjugates and their ability to target cholecystokinin-R in small-animal models.	Histidine	111-120	gastrin	Mus musculus	174-181
19167761-3	2009	We found that B*2709 with a histidine at position 116 was strongly associated with the transporter associated with antigen processing complex, correlated with lower, non-conformational expression on the cell surface, delayed maturation rate and minimal conformational and non-conformational homodimer formation.	Histidine	28-37	transporter 1, ATP binding cassette subfamily B member	Homo sapiens	87-133
19146426-8	2009	This His/Arg-18 mutation results in reduced affinity binding of human IAPP to insulin in comparison to rat IAPP as it is detected by surface plasmon resonance biosensor analysis.	Histidine	5-8	insulin	Homo sapiens	78-85
19028475-5	2009	Second, the Kvbeta subunits (AKR6A3, AKR6A5 and AKR6A9) which modulate opening of the voltage-gated potassium channel (Kv1) by oxidizing NADPH, have an Asn substituted for the His.	Histidine	176-179	potassium voltage-gated channel subfamily A regulatory beta subunit 3	Homo sapiens	48-54
19081673-1	2009	The Hint1 protein, a member of the histidine triad (HIT) family, is highly conserved in diverse species and ubiquitously expressed in mammalian tissues.	Histidine	35-44	histidine triad nucleotide binding protein 1	Homo sapiens	4-9
19118607-2	2009	Modification of His-48 (according to the sequence alignment with porcine pancreatic PLA(2)) with p-bromophenacyl bromide (BPB) caused over 99.9% drop in enzymatic activity Naja naja atra PLA(2).	Histidine	16-19	phospholipase A2 group IB	Homo sapiens	84-90
19118607-2	2009	Modification of His-48 (according to the sequence alignment with porcine pancreatic PLA(2)) with p-bromophenacyl bromide (BPB) caused over 99.9% drop in enzymatic activity Naja naja atra PLA(2).	Histidine	16-19	phospholipase A2 group IB	Homo sapiens	187-193
19167089-2	2009	As assayed by DNase I protection, DNA binding by TFIIIA (transcription factor IIIA, prototypical Cys(2)His(2) zinc finger protein), was inhibited by micromolar amounts of ebselen.	Histidine	103-106	general transcription factor IIIA	Homo sapiens	49-55
18991813-9	2009	On the basis of our results, a catalytic mechanism is proposed for hPHPT1: the imidazole ring of His(53) serves as a general base to activate a water molecule, and the activated water would attack the substrate as a nucleophile in the catalysis; the positively charged side chain of Lys(21) can help stabilize the transition state.	Histidine	97-100	phosphohistidine phosphatase 1	Homo sapiens	67-73
19234124-6	2009	However, the His&gt;Arg change substantially decreases the stability and affinity of HLA-A2 association, consistent with the reduced immunogenicity of the HA-1(R) variant.	Histidine	13-16	Rho GTPase activating protein 45	Homo sapiens	155-159
19167089-2	2009	As assayed by DNase I protection, DNA binding by TFIIIA (transcription factor IIIA, prototypical Cys(2)His(2) zinc finger protein), was inhibited by micromolar amounts of ebselen.	Histidine	103-106	general transcription factor IIIA	Homo sapiens	57-82
19246739-0	2009	Biological characterization of the zinc site coordinating histidine residues of staphylococcal enterotoxin C2.	Histidine	58-67	fucosyltransferase 2	Homo sapiens	80-109
19246739-2	2009	Although the previously determined crystal structure of SEC2 revealed that some histidine residues (His47, His118 and His122) contribute to the binding of zinc ions, little is known about their biological roles in SEC2.	Histidine	80-89	fucosyltransferase 2	Homo sapiens	56-60
19246739-3	2009	This prompted us to investigate the role of the zinc site coordinating histidine residues in the biological activities of SEC2.	Histidine	71-80	fucosyltransferase 2	Homo sapiens	122-126
19246739-6	2009	However, mutant SEC2-H47A could cause significant emetic and febrile responses in comparison with the other two histidine mutants.	Histidine	112-121	fucosyltransferase 2	Homo sapiens	16-20
19246739-7	2009	These findings suggested that the zinc-coordinating histidine residues play significant roles in superantigen and toxic activities of SEC2 and further implied that superantigen and febrile activities could be separable in staphylococcal enterotoxins.	Histidine	52-61	fucosyltransferase 2	Homo sapiens	134-138
19074135-0	2009	Mutation of histidine 105 in the T1 domain of the potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4.	Histidine	12-21	potassium voltage-gated channel modifier subfamily G member 4	Homo sapiens	105-110
19135030-2	2009	Amino-acid sequencing analysis reveals that meprin A and meprin alpha cleave pro-IL-1beta at the His(115)-Asp(116) bond, which is one amino acid N-terminal to the caspase-1 cleavage site and five amino acids C-terminal to the meprin beta site.	Histidine	97-100	interleukin 1 beta	Mus musculus	81-89
19074135-0	2009	Mutation of histidine 105 in the T1 domain of the potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4.	Histidine	12-21	potassium voltage-gated channel modifier subfamily G member 4	Homo sapiens	115-120
19074135-4	2009	Using a yeast two-hybrid assay, we found that substitution of the corresponding histidine 105 in Kv2.1 by valine (H105V) or arginine (H105R) disrupted the interaction of the T1 domain of Kv2.1 with the T1 domains of both Kv6.3 and Kv6.4, whereas interaction of the T1 domain of Kv2.1 with itself was unaffected by this mutation.	Histidine	80-89	potassium voltage-gated channel modifier subfamily G member 4	Homo sapiens	221-226
19074135-4	2009	Using a yeast two-hybrid assay, we found that substitution of the corresponding histidine 105 in Kv2.1 by valine (H105V) or arginine (H105R) disrupted the interaction of the T1 domain of Kv2.1 with the T1 domains of both Kv6.3 and Kv6.4, whereas interaction of the T1 domain of Kv2.1 with itself was unaffected by this mutation.	Histidine	80-89	potassium voltage-gated channel modifier subfamily G member 4	Homo sapiens	231-236
19056490-9	2009	Two motifs from the intracellular domain of FGFRL1 appeared to be responsible for this differential distribution, a tandem tyrosine based motif and a histidine-rich sequence.	Histidine	150-159	fibroblast growth factor receptor like 1	Homo sapiens	44-50
19194009-1	2009	SirR, a metal-dependent transcriptional repressor from Mycobacterium tuberculosis (Rv2788), was cloned in pQE30 expression vector with an N-terminal His(6) tag for heterologous overexpression in Escherichia coli M15 (pREP4) cells and purified to homogeneity using chromatographic procedures.	Histidine	149-152	transcriptional repressor SirR	Mycobacterium tuberculosis H37Rv	0-4
19027739-11	2009	RESULTS: In the IL-10(-/-) transfer model, dietary histidine, but not alanine, reduced histologic damage and colon weight and TNF-alpha mRNA expression.	Histidine	51-60	interleukin 10	Mus musculus	16-21
19027739-11	2009	RESULTS: In the IL-10(-/-) transfer model, dietary histidine, but not alanine, reduced histologic damage and colon weight and TNF-alpha mRNA expression.	Histidine	51-60	tumor necrosis factor	Mus musculus	126-135
18758940-6	2009	A mixture of poly-LacNAc-structures covalently coupled to functionalized microtiter plates were identified for best binding to our model galectin His(6)CGL2.	Histidine	146-149	granzyme H	Homo sapiens	152-156
19027739-12	2009	Histidine inhibited LPS-induced TNF-alpha and IL-6 production by mouse macrophages in a concentration-dependent manner, whereas alanine or histidine-related metabolites had no such effect.	Histidine	0-9	tumor necrosis factor	Mus musculus	32-41
19027739-12	2009	Histidine inhibited LPS-induced TNF-alpha and IL-6 production by mouse macrophages in a concentration-dependent manner, whereas alanine or histidine-related metabolites had no such effect.	Histidine	0-9	interleukin 6	Mus musculus	46-50
18826375-9	2009	The biological roles of the histidine-regulated conformational equilibrium of M-ficolin are discussed in terms of the self and non-self discrimination mechanism.	Histidine	28-37	ficolin 1	Homo sapiens	78-87
19199251-5	2009	RESULTS: A missense mutation of GAT>CAT was identified at codon 1441 of the COL1A1 gene from the family, which resulted in the replacement of aspartic acid by histidine (D1441H).	Histidine	159-168	catalase	Homo sapiens	36-39
19032942-3	2009	Here we show that CREB-binding protein (CBP)/p300-interacting transactivator with ED-rich tail 2 (Cited2), which binds to the cysteine-histidine-rich region 1 of p300 and CBP, regulates muscle mass in vitro.	Histidine	135-144	CREB binding protein	Homo sapiens	18-38
19032942-3	2009	Here we show that CREB-binding protein (CBP)/p300-interacting transactivator with ED-rich tail 2 (Cited2), which binds to the cysteine-histidine-rich region 1 of p300 and CBP, regulates muscle mass in vitro.	Histidine	135-144	CREB binding protein	Homo sapiens	40-43
19032942-3	2009	Here we show that CREB-binding protein (CBP)/p300-interacting transactivator with ED-rich tail 2 (Cited2), which binds to the cysteine-histidine-rich region 1 of p300 and CBP, regulates muscle mass in vitro.	Histidine	135-144	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2	Homo sapiens	98-104
19032942-3	2009	Here we show that CREB-binding protein (CBP)/p300-interacting transactivator with ED-rich tail 2 (Cited2), which binds to the cysteine-histidine-rich region 1 of p300 and CBP, regulates muscle mass in vitro.	Histidine	135-144	CREB binding protein	Homo sapiens	171-174
19049349-6	2008	Docking of 5v, 5zf, and 5za into the binding pocket of the PDE4 catalytic domain revealed a similar binding profile to PDE4 with rolipram except that the fluorine atoms of the difluoromethyl groups of 5v, 5za, and 5zf are within a reasonable range for hydrogen bond formation with the amide hydrogen of Thr 333 and the long alkyl chain bears additional van der Waals interactions with His 160, Asp 318, and Tyr 159.	Histidine	385-388	phosphodiesterase 4A	Homo sapiens	59-63
18996422-0	2009	Histidine at position 1042 of the p150 region of a KRT live attenuated rubella vaccine strain is responsible for the temperature sensitivity.	Histidine	0-9	keratin 126, pseudogene	Homo sapiens	51-54
18996422-11	2009	Thus, we concluded that one mutation, of the histidine at position 1042 of p150, was essential for the ts phenotype of the KRT strain, and structural proteins of KRT had an additive effect with H1042Y on the ts phenotype.	Histidine	45-54	keratin 126, pseudogene	Homo sapiens	123-126
19289209-7	2009	NMR has also provided a residue-specific view of the titration of histidine residues at the LC8 dimer interface, and of a nascent helix in one of the binding partners, the primarily disordered dynein intermediate chain IC74.	Histidine	66-75	dynein light chain LC8-type 1	Homo sapiens	92-95
19081971-6	2009	All complexes could be seen as model compounds for the active site of the enzyme ACMSD, where the Co(II) complexes reflected the structural flexibility found in case of two histidine (His177 and His228) residues found in the active site of the enzyme.	Histidine	173-182	aminocarboxymuconate semialdehyde decarboxylase	Homo sapiens	81-86
19081971-6	2009	All complexes could be seen as model compounds for the active site of the enzyme ACMSD, where the Co(II) complexes reflected the structural flexibility found in case of two histidine (His177 and His228) residues found in the active site of the enzyme.	Histidine	173-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-104
19049349-6	2008	Docking of 5v, 5zf, and 5za into the binding pocket of the PDE4 catalytic domain revealed a similar binding profile to PDE4 with rolipram except that the fluorine atoms of the difluoromethyl groups of 5v, 5za, and 5zf are within a reasonable range for hydrogen bond formation with the amide hydrogen of Thr 333 and the long alkyl chain bears additional van der Waals interactions with His 160, Asp 318, and Tyr 159.	Histidine	385-388	phosphodiesterase 4A	Homo sapiens	119-123
18991392-4	2008	A dyad of His-464" and Glu-469" in TrxR acts as the acid-base catalyst of the dithiol-disulfide interchange reactions required in catalysis [Huang, H.-H., et al.	Histidine	10-13	Thioredoxin reductase-1	Drosophila melanogaster	35-39
18829452-7	2008	Here we report on the interactions of RhoA, Rac1, and Cdc42 with mDia1 and an mDia1 mutant (mDia(N)-Thr-Ser-His (TSH)), which based on structural information should mimic mDia2 and -3.	Histidine	108-111	ras homolog family member A	Homo sapiens	38-42
18829452-10	2008	The triple N motif of mDia1 allows tight interaction with Rho because of the presence of Phe-106, whereas the corresponding His-104 in Rac and Cdc42 forms a complementary interface with the TSH motif in mDia2/3.	Histidine	124-127	AKT serine/threonine kinase 1	Homo sapiens	135-138
19206287-1	2008	We have demonstrated that nanostructures, and in particular nanorings incorporating a homodimeric enzyme, can be prepared by chemically induced self-assembly of dihydrofolate reductase (DHFR)-histidine triad nucleotide binding 1 (Hint1) fusion proteins.	Histidine	192-201	histidine triad nucleotide binding protein 1	Homo sapiens	230-235
18991392-10	2008	On the basis of our observations, it is proposed that the function of Glu-469" is to facilitate the positioning of His-464" toward the interchange thiol, Cys-57, as suggested for the analogous residue in glutathione reductase.	Histidine	115-118	Thioredoxin reductase-1	Drosophila melanogaster	204-225
18991392-8	2008	The pH dependence of V(max) for both glutamate variants yields pK(a) values of 6.0 and 8.7, compared to those in the wild-type enzyme of 6.4 and 9.3, respectively, indicating that the basicity of His-464" in TrxR in complex with its substrate, DmTrx-2, is significantly lower in the glutamate variants than in wild-type enzyme.	Histidine	196-199	Thioredoxin reductase-1	Drosophila melanogaster	208-212
18717684-0	2008	Deletions of BRCA1/2 and p53 R248W gain-of-function mutation suggest impaired homologous recombination repair in fragile histidine triad-negative sebaceous gland carcinomas.	Histidine	121-130	tumor protein p53	Homo sapiens	25-28
19127115-7	2008	Direct sequencing of TP53 gene exons 5, 6, 8, 9, and 11 revealed a ermline missense mutation, resulting in an amino acid change from an arginine to a histidine (g.13203G&gt;A, p.R175H).	Histidine	150-159	tumor protein p53	Homo sapiens	21-25
19032907-7	2008	In addition, we found that HCBMCs generate the transcription of histidine decarboxylase (HDC), the enzyme responsible for the generation of histamine from histidine, after SP treatment.	Histidine	64-73	tachykinin precursor 1	Homo sapiens	172-174
19036708-2	2008	Here, the authors coexpressed the human class Ia PI3 kinase p110alpha catalytic domain with an N-terminal His-tag and the p85alpha regulatory domain in Sf9 insect cells.	Histidine	106-109	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	60-69
19120899-1	2008	BACKGROUND: The fragile histidine triad (FHIT) functions as a tumor suppressor, and giving adenoviral-FHIT (Ad-FHIT) is thus expected to be clinically beneficial.	Histidine	24-33	fragile histidine triad gene	Mus musculus	41-45
19120899-1	2008	BACKGROUND: The fragile histidine triad (FHIT) functions as a tumor suppressor, and giving adenoviral-FHIT (Ad-FHIT) is thus expected to be clinically beneficial.	Histidine	24-33	fragile histidine triad gene	Mus musculus	102-106
19134269-4	2008	RESULTS: In ZZJ family, mutation G12101A was identified in exon 21 of MYBPC3 gene in 4 family members [the arginine (R) converted to histidine (H)].	Histidine	133-142	myosin binding protein C3	Homo sapiens	70-76
19000132-3	2008	The nucleotide sequence of DRB1*1461 is identical to DRB1*1404 except for a single substitution in codon 16 (TAT--&gt;CAT), leading to a change from Tyr to His.	Histidine	156-159	major histocompatibility complex, class II, DR beta 1	Homo sapiens	27-31
19000132-3	2008	The nucleotide sequence of DRB1*1461 is identical to DRB1*1404 except for a single substitution in codon 16 (TAT--&gt;CAT), leading to a change from Tyr to His.	Histidine	156-159	major histocompatibility complex, class II, DR beta 1	Homo sapiens	53-57
18790835-9	2008	Moreover, mutation of a histidine residue in the COOH-terminal transmembrane domain to alanine (Bnip3H173A) almost completely inhibited the cell death activity of Bnip3.	Histidine	24-33	BCL2 interacting protein 3	Homo sapiens	96-101
18723589-2	2008	Peptide segments that include the characteristic histidine (His) diad, His(13) and His(14), efficiently block the Abeta channel activity, blocking Abeta cytotoxicity.	Histidine	49-58	amyloid beta precursor protein	Homo sapiens	114-119
18723589-2	2008	Peptide segments that include the characteristic histidine (His) diad, His(13) and His(14), efficiently block the Abeta channel activity, blocking Abeta cytotoxicity.	Histidine	49-58	amyloid beta precursor protein	Homo sapiens	147-152
18723589-2	2008	Peptide segments that include the characteristic histidine (His) diad, His(13) and His(14), efficiently block the Abeta channel activity, blocking Abeta cytotoxicity.	Histidine	60-63	amyloid beta precursor protein	Homo sapiens	114-119
18723589-2	2008	Peptide segments that include the characteristic histidine (His) diad, His(13) and His(14), efficiently block the Abeta channel activity, blocking Abeta cytotoxicity.	Histidine	60-63	amyloid beta precursor protein	Homo sapiens	147-152
18723589-2	2008	Peptide segments that include the characteristic histidine (His) diad, His(13) and His(14), efficiently block the Abeta channel activity, blocking Abeta cytotoxicity.	Histidine	71-74	amyloid beta precursor protein	Homo sapiens	114-119
18723589-2	2008	Peptide segments that include the characteristic histidine (His) diad, His(13) and His(14), efficiently block the Abeta channel activity, blocking Abeta cytotoxicity.	Histidine	71-74	amyloid beta precursor protein	Homo sapiens	147-152
18723589-2	2008	Peptide segments that include the characteristic histidine (His) diad, His(13) and His(14), efficiently block the Abeta channel activity, blocking Abeta cytotoxicity.	Histidine	71-74	amyloid beta precursor protein	Homo sapiens	114-119
18723589-2	2008	Peptide segments that include the characteristic histidine (His) diad, His(13) and His(14), efficiently block the Abeta channel activity, blocking Abeta cytotoxicity.	Histidine	71-74	amyloid beta precursor protein	Homo sapiens	147-152
18723589-3	2008	We hypothesize that the vicinal His-His peptides coordinate with the rings of His in the mouth of the pore, thus blocking the flow of calcium ions through the channel, with consequent blocking of Abeta cytotoxicity.	Histidine	32-35	amyloid beta precursor protein	Homo sapiens	196-201
18723589-3	2008	We hypothesize that the vicinal His-His peptides coordinate with the rings of His in the mouth of the pore, thus blocking the flow of calcium ions through the channel, with consequent blocking of Abeta cytotoxicity.	Histidine	36-39	amyloid beta precursor protein	Homo sapiens	196-201
18723589-3	2008	We hypothesize that the vicinal His-His peptides coordinate with the rings of His in the mouth of the pore, thus blocking the flow of calcium ions through the channel, with consequent blocking of Abeta cytotoxicity.	Histidine	36-39	amyloid beta precursor protein	Homo sapiens	196-201
18723589-7	2008	These data reinforce the premise that His residues within the Abeta channel sequence are in the pathway of ion flow.	Histidine	38-41	amyloid beta precursor protein	Homo sapiens	62-67
18725203-0	2008	An abnormal pK(a) value of internal histidine of the insulin molecule revealed by neutron crystallographic analysis.	Histidine	36-45	insulin	Homo sapiens	53-60
18847222-9	2008	In support of this, chemical modification of the Abeta peptide was examined using (1)H NMR, and specific oxidation sites within the peptide were identified at the histidine and methionine residues.	Histidine	163-172	amyloid beta precursor protein	Homo sapiens	49-54
18844375-0	2008	The dual histidine motif in the active site of Pin1 has a structural rather than catalytic role.	Histidine	9-18	peptidylprolyl isomerase ESS1	Saccharomyces cerevisiae S288C	47-51
18986390-4	2008	The glutathione-S-transferase (GST) and histidine-tagged construct, E1554-R1668 of VWF (VWF115) was assayed via enzyme-linked immunosorbent assay: VWF115 was bound to anti-GST coated plates, digested with rADAMTS13, and intact VWF115 detected via horseradish peroxidase-labelled anti-histidine tag antibody.	Histidine	40-49	von Willebrand factor	Homo sapiens	83-86
18986390-4	2008	The glutathione-S-transferase (GST) and histidine-tagged construct, E1554-R1668 of VWF (VWF115) was assayed via enzyme-linked immunosorbent assay: VWF115 was bound to anti-GST coated plates, digested with rADAMTS13, and intact VWF115 detected via horseradish peroxidase-labelled anti-histidine tag antibody.	Histidine	284-293	von Willebrand factor	Homo sapiens	83-86
18599641-7	2008	The novel distorted six-coordinated (3N3O) geometry around copper in the Abeta-Cu(2+) complexes include three histidines: glutamic, or/and aspartic acid, and axial water.	Histidine	110-120	amyloid beta precursor protein	Homo sapiens	73-78
18708479-3	2008	Herein we characterized the role of His-226 in iodide transport of SLC5A5.	Histidine	36-39	solute carrier family 5 member 5	Homo sapiens	67-73
18708479-4	2008	His-226, a highly conserved extracellular residue among SLC5A5 homologs, was replaced with alanine, aspartic acid, glutamic acid, or lysine.	Histidine	0-3	solute carrier family 5 member 5	Homo sapiens	56-62
18703510-5	2008	We successfully pulled down histidine-tagged hsp90alpha- and PA28alpha-induced, newly assembled 26 S proteasomes from the cell extracts for in vitro epitope production assay, and we found these structures to be sensitive to geldanamycin, an hsp90 inhibitor.	Histidine	28-37	proteasome activator subunit 1	Homo sapiens	61-70
18802608-0	2008	The unusual binding abilities of the His-analogue of Arg-vasopressin towards Cu2+.	Histidine	37-40	arginine vasopressin	Homo sapiens	57-68
18802608-3	2008	The replacement of both Cys by His residues in the vasopressin sequence results in a very significant increase in the efficiency of Cu2+ binding.	Histidine	31-34	arginine vasopressin	Homo sapiens	51-62
18796614-3	2008	We now show that the mammalian protein histidine phosphatase (PHPT-1) directly binds and inhibits KCa3.1 by dephosphorylating histidine 358 on KCa3.1.	Histidine	39-48	phosphohistidine phosphatase 1	Homo sapiens	62-68
18508040-17	2008	According to the putative water-activation mechanism of G117H BChE, a new histidine/aspartate dyad was introduced into the active center of human AChE at the optimum location for hydrolysis of the OP adduct.	Histidine	74-83	acetylcholinesterase (Cartwright blood group)	Homo sapiens	146-150
18681435-7	2008	The electronic absorption spectrum and nu(Fe-CO)/nu(CO) vibrational frequencies of the CO-heme-HSA-ibuprofen complex, together with the observation of a Fe-His Raman mode at 218 cm(-1) upon photolysis of the CO complex and the low spin EPR g values indicate that a His residue is one of the low spin axial ligands, the sixth ligand probably being Tyr161.	Histidine	156-159	albumin	Homo sapiens	95-98
18707164-3	2008	The specific residues of MDM2 that have dominant binding interactions with p53 are specifically identified to be (51)Lys, (54)Leu, (62)Met, (67)Tyr, (72)Gln, (94)Lys, (96)His, and (100)Tyr.	Histidine	171-174	tumor protein p53	Homo sapiens	75-78
18681435-7	2008	The electronic absorption spectrum and nu(Fe-CO)/nu(CO) vibrational frequencies of the CO-heme-HSA-ibuprofen complex, together with the observation of a Fe-His Raman mode at 218 cm(-1) upon photolysis of the CO complex and the low spin EPR g values indicate that a His residue is one of the low spin axial ligands, the sixth ligand probably being Tyr161.	Histidine	265-268	albumin	Homo sapiens	95-98
18200441-4	2008	In our case-control study, we assess whether Msp1 polymorphism of CYP1A1 (CYP1A1*2A), and His(113) in exon 3 and Arg(139) in exon 4 of the mEH susceptibility genotypes, tobacco-use and age factors contribute to bladder cancer risk among Indians.	Histidine	90-93	epoxide hydrolase 1, microsomal	Mus musculus	139-142
18768683-6	2008	Of the 23 members of the aspartate-histidine-histidine-cysteine (DHHC) domain containing proteins, DHHC-7 most strongly stimulated palmitoylation of NCAM, and enzyme activity was enhanced by FGF2.	Histidine	35-44	fibroblast growth factor 2	Homo sapiens	191-195
18765914-2	2008	A heterodimer containing a His-tagged p50 subunit (p50) and a p50-interacting domain of the p66 subunit (p66(N)) was crystallized.	Histidine	27-30	nuclear factor kappa B subunit 1	Homo sapiens	38-41
18765914-2	2008	A heterodimer containing a His-tagged p50 subunit (p50) and a p50-interacting domain of the p66 subunit (p66(N)) was crystallized.	Histidine	27-30	nuclear factor kappa B subunit 1	Homo sapiens	51-54
18765914-2	2008	A heterodimer containing a His-tagged p50 subunit (p50) and a p50-interacting domain of the p66 subunit (p66(N)) was crystallized.	Histidine	27-30	nuclear factor kappa B subunit 1	Homo sapiens	51-54
18611412-4	2008	Expression of histidine-tagged fusion truncated VP7 protein with a molecular mass of 36 kDa was determined by Western blot analysis using anti-His antibody.	Histidine	14-23	VP7	Bluetongue virus	48-51
18853057-6	2008	RESULTS: The purified ACE (MM = 140 kDa), releases angiotensin II, hydrolyses bradykinin and the Hip-His-Leu substrate.	Histidine	101-104	angiotensin I converting enzyme	Homo sapiens	22-25
18611412-4	2008	Expression of histidine-tagged fusion truncated VP7 protein with a molecular mass of 36 kDa was determined by Western blot analysis using anti-His antibody.	Histidine	143-146	VP7	Bluetongue virus	48-51
18571500-3	2008	Lipidex-1000 binding assays indicated that MmDGAT1(1-95)His(6) interacted with long chain fatty acyl-CoAs similar to observations on DGAT1 from oilseed rape (Brassica napus).	Histidine	56-59	diacylglycerol O-acyltransferase 1-like	Brassica napus	45-50
18542951-2	2008	Thus, a fusion gene for the expression of the human proteasome subunit alpha 6 (hPSA6) and human profilin I (hProI) were assembled, respectively, with a His.tag marker at the C-terminal and displayed on yeast surface.	Histidine	153-156	proteasome 20S subunit alpha 6	Homo sapiens	52-78
18539597-6	2008	Mutagenesis of the exosite in the V-B loop at Thr-205 and His-206 that vary among MMP sequences established that this site supports the high specific activity toward alpha1(V) fluorescent THP without affecting general MMP activity.	Histidine	58-61	collagen type V alpha 1 chain	Homo sapiens	166-175
18652486-0	2008	Analysis of site-specific histidine protonation in human prolactin.	Histidine	26-35	prolactin	Homo sapiens	57-66
18652486-4	2008	hPRL has a surprising number of nine histidines, nearly all of which are present on the protein surface.	Histidine	37-47	prolactin	Homo sapiens	0-4
18474604-7	2008	A single amino acid substitution of Asp at residue position 218 of TRAIL to His or Tyr was predicted to have a favorable effect on DR4 binding specificity.	Histidine	76-79	TNF superfamily member 10	Homo sapiens	67-72
18542951-2	2008	Thus, a fusion gene for the expression of the human proteasome subunit alpha 6 (hPSA6) and human profilin I (hProI) were assembled, respectively, with a His.tag marker at the C-terminal and displayed on yeast surface.	Histidine	153-156	profilin 1	Homo sapiens	97-107
18318660-10	2008	Exchanging His(99) of human uPA by a tyrosine residue, the corresponding residue in murine uPA, conferred mupain-1 susceptibility on to the latter.	Histidine	11-14	plasminogen activator, urokinase	Homo sapiens	28-31
18566479-1	2008	Endothelial lipase (EL) is a 482-amino-acid protein from the triglyceride lipase gene family that uses a Ser-His-Asp triad for catalysis.	Histidine	109-112	lipase G, endothelial type	Homo sapiens	0-18
18566479-1	2008	Endothelial lipase (EL) is a 482-amino-acid protein from the triglyceride lipase gene family that uses a Ser-His-Asp triad for catalysis.	Histidine	109-112	lipase G, endothelial type	Homo sapiens	20-22
18468678-11	2008	[D-His(26)]-NPY did not affect the overall somatic signs associated with precipitated nicotine withdrawal, but decreased the number of abdominal constrictions.	Histidine	3-6	neuropeptide Y	Rattus norvegicus	12-15
18465877-5	2008	Dimerization was confirmed by histidine tag pull-down experiments that demonstrate the association of untagged NCX1 with histidine-tagged NCX1.	Histidine	30-39	solute carrier family 8 member A1	Homo sapiens	111-115
18465877-5	2008	Dimerization was confirmed by histidine tag pull-down experiments that demonstrate the association of untagged NCX1 with histidine-tagged NCX1.	Histidine	30-39	solute carrier family 8 member A1	Homo sapiens	138-142
18465877-5	2008	Dimerization was confirmed by histidine tag pull-down experiments that demonstrate the association of untagged NCX1 with histidine-tagged NCX1.	Histidine	121-130	solute carrier family 8 member A1	Homo sapiens	111-115
18465877-5	2008	Dimerization was confirmed by histidine tag pull-down experiments that demonstrate the association of untagged NCX1 with histidine-tagged NCX1.	Histidine	121-130	solute carrier family 8 member A1	Homo sapiens	138-142
18342861-2	2008	A molecular form known as chicken GnRH II ([His(5) Trp(7) Tyr(8)] GnRH, cGnRH II) is widely distributed in vertebrates, and has recently been implicated in the regulation of sexual behavior and food intake in an insectivore, the musk shrew.	Histidine	44-47	mitochondrial ribosomal protein S26	Gallus gallus	34-41
18504314-4	2008	Here we investigate the proximity of S4 and the pore domain in functional Kv1.2 channels in a native membrane environment using electrophysiological analysis of intersubunit histidine metallic bridges formed between the first arginine of S4 (R294) and residues A351 or D352 of the pore domain.	Histidine	174-183	potassium voltage-gated channel subfamily A member 2	Homo sapiens	74-79
18502256-9	2008	The HIS exercise resulted in a greater activation of AMPK compared with LIS, but insulin sensitivity was higher after LIS compared with HIS.	Histidine	4-7	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	53-57
20641421-4	2004	VIP (HSDAVFTDNYTRLRKQMAVKKYLNSILN-NH2) is a hydrophobic, basic peptide that contains three lysine residues (1520, and 21, ), two arginine residues (12 and 14, ), two tyrosine residues (10 and 22, ), an essential histidine residue at the N terminus, and an amidated C-terminus (10).	Histidine	212-221	vasoactive intestinal peptide	Homo sapiens	0-3
20641421-6	2004	Like VIP, PACAP27 also has an amidated C-terminal and histidine residue at the N terminus.	Histidine	54-63	vasoactive intestinal peptide	Homo sapiens	5-8
20641421-18	2004	In the initial (99m)Tc radiolabeling, VIP was conjugated at the N terminal of the histidine residue with a bifunctional chelating agent for (99m)Tc labeling.	Histidine	82-91	vasoactive intestinal peptide	Homo sapiens	38-41
20641421-19	2004	This (99m)Tc-VIP analog had relatively high radiochemical impurities and a loss of biological activity because the histidine residue was required for the VIP biological activity.	Histidine	115-124	vasoactive intestinal peptide	Homo sapiens	13-16
20641421-19	2004	This (99m)Tc-VIP analog had relatively high radiochemical impurities and a loss of biological activity because the histidine residue was required for the VIP biological activity.	Histidine	115-124	vasoactive intestinal peptide	Homo sapiens	154-157
18705504-1	2008	OBJECTIVE: To investigate the suppression effect of exogenous fragile histidine triad (FHIT) gene on biological property of MEC-1 cells.	Histidine	70-79	fragile histidine triad gene	Mus musculus	87-91
18468678-13	2008	These findings indicate that NPY and [D-His(26)]-NPY attenuate somatic nicotine withdrawal signs, but do not prevent the deficit in brain reward function associated with precipitated nicotine withdrawal.	Histidine	40-43	neuropeptide Y	Rattus norvegicus	49-52
18377892-5	2008	Comparison of amino acid sequences of the transmembrane domain of the thrombopoietin receptor between human and three animal species led us to hypothesize that histidine 499 is necessary for the reactivity to the thrombopoietin mimetics.	Histidine	160-169	MPL proto-oncogene, thrombopoietin receptor	Homo sapiens	70-93
18377892-5	2008	Comparison of amino acid sequences of the transmembrane domain of the thrombopoietin receptor between human and three animal species led us to hypothesize that histidine 499 is necessary for the reactivity to the thrombopoietin mimetics.	Histidine	160-169	thrombopoietin	Homo sapiens	70-84
18596417-7	2008	Here, we summarize these findings with special emphasis on the histidine triad proteins Hint1 and Fhit and their repressive activity on the beta-catenin signaling function.	Histidine	63-72	histidine triad nucleotide binding protein 1	Homo sapiens	88-93
18234834-1	2008	It has been found that with mutation of two surface residues (Lys(22) --&gt; Glu and His(104) --&gt; Arg) in human purine nucleoside phosphorylase (hPNP), there is an enhancement of catalytic activity in the chemical step.	Histidine	85-88	purine nucleoside phosphorylase	Homo sapiens	115-146
18359301-5	2008	They resemble ferrous LPO, being five-coordinated high-spin species that are distinguished by the strength of the proximal Fe-histidine bond.	Histidine	126-135	lactoperoxidase	Homo sapiens	22-25
18263580-2	2008	We have characterized the kinetic mechanism of recombinant His-tagged PRMT6 using a mass spectrometry method for monitoring the methylation of a series of peptides bearing a single arginine, MMA, or aDMA residue.	Histidine	59-62	protein arginine methyltransferase 6	Homo sapiens	70-75
17708750-2	2008	To better exert the activities of the two cytokines and study them in a mouse model, we have constructed a bifunctional protein, hIL-2-mGM-CSF (human IL-2-mouse GM-CSF), fused to a C-terminal tag of six histidine residues (His(6)).	Histidine	203-212	interleukin 2	Homo sapiens	129-134
17708750-2	2008	To better exert the activities of the two cytokines and study them in a mouse model, we have constructed a bifunctional protein, hIL-2-mGM-CSF (human IL-2-mouse GM-CSF), fused to a C-terminal tag of six histidine residues (His(6)).	Histidine	223-226	interleukin 2	Homo sapiens	129-134
18222027-5	2008	The post-intake of histidine and carnosine significantly decreased MDA formations, increased GSH content, enhanced catalase and GPX activities, and suppressed CYP2E1 activity (P&lt;0.05), in which the effects on catalase and CYP2E1 activities were dose-dependent (P&lt;0.05).	Histidine	19-28	catalase	Mus musculus	115-123
18222027-5	2008	The post-intake of histidine and carnosine significantly decreased MDA formations, increased GSH content, enhanced catalase and GPX activities, and suppressed CYP2E1 activity (P&lt;0.05), in which the effects on catalase and CYP2E1 activities were dose-dependent (P&lt;0.05).	Histidine	19-28	catalase	Mus musculus	212-220
18222027-8	2008	Histidine and carnosine post-treatments significantly and dose-dependently upregulated catalase mRNA, and down-regulated mRNA expression of IL-6 and TNF-alpha (P&lt;0.05).	Histidine	0-9	catalase	Mus musculus	87-95
18222027-8	2008	Histidine and carnosine post-treatments significantly and dose-dependently upregulated catalase mRNA, and down-regulated mRNA expression of IL-6 and TNF-alpha (P&lt;0.05).	Histidine	0-9	interleukin 6	Mus musculus	140-144
18222027-8	2008	Histidine and carnosine post-treatments significantly and dose-dependently upregulated catalase mRNA, and down-regulated mRNA expression of IL-6 and TNF-alpha (P&lt;0.05).	Histidine	0-9	tumor necrosis factor	Mus musculus	149-158
18255153-8	2008	In the vanadate-inhibited phosphatases - structural analogs of the transition state in phosphoester hydrolysis by the native enzymes - the position of the axial histidine can also be taken by cysteinate or serinate, a fact which has implications for the insulin-mimetic potential of vanadate.	Histidine	161-170	insulin	Homo sapiens	254-261
18315550-7	2008	The crystal structure of thrombin in complex with FM19 shows that the N-terminal D-Arg retrobinds into the S1 pocket, its second residue Oic interacts with His-57, Tyr-60a and Trp-60d, and its C-terminal p-methyl Phe engages thrombin"s aryl binding site composed of Ile-174, Trp-215, and Leu-99.	Histidine	156-159	coagulation factor II	Mus musculus	25-33
18280261-2	2008	The copper-binding sites in PrP are located in the N-terminal region of the molecule and comprise a series of tandem repeats of the sequence PHGGGWGQ together with two histidines at residues 96 and 111 (human PrP numbering).	Histidine	168-178	prion protein	Homo sapiens	28-31
18405501-9	2008	Beta globin gene sequentiation showed the CD92 His --&gt; Pro mutation Hb Newcastle in heterocygote condition in patient and her mother.	Histidine	47-50	solute carrier family 44 member 1	Homo sapiens	42-46
18272395-4	2008	For the purpose of crystallization, C-terminal catalytic segment of human Lyn kinase conjugating hexahistidine purification tag (His-tag) was expressed in Sf21 insect cells.	Histidine	129-132	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	74-77
18328704-4	2008	In this study, we generated mice carrying an identical point mutation to that of the KE family, yielding the equivalent arginine-to-histidine substitution in the Foxp2 DNA-binding domain.	Histidine	132-141	forkhead box P2	Mus musculus	162-167
18302339-6	2008	We found that the work of adhesion between PIP 2-bound ezrin and F-actin is substantially larger than that measured between F-actin and ezrin bound to the membrane via the His tag.	Histidine	172-175	prolactin induced protein	Homo sapiens	43-46
18294964-3	2008	A structural model of AMCase reveals the presence of a conserved histidine residue in the active site.	Histidine	65-74	chitinase acidic	Homo sapiens	22-28
18241886-6	2008	Unlike the bent FMN ring structures present in most NTR complexes currently known, the flavin system in the Ec_ydjA structure maintains a flat ring conformation, which is sandwiched between a Trp and a His residue from each monomer.	Histidine	202-205	ydjA	Escherichia coli K-12	111-115
18178555-6	2008	CPA6 has a preference for large hydrophobic C-terminal amino acids as well as histidine.	Histidine	78-87	carboxypeptidase A6	Homo sapiens	0-4
17890387-2	2008	External Zn(2+) determines a potentiation of the current mediated by the dimeric construct KDC1-KAT1, which has been ascribed to zinc binding at a site comprising three histidines located at the S3-S4 (H161, H162) and S5-S6 (H224) linkers of KDC1.	Histidine	169-179	kynurenine aminotransferase 1 L homeolog	Xenopus laevis	96-100
18096676-8	2008	Similar binding (1.0 +/- 0.4 pmol (3)H-CBZ bound/pmol CYP3A4) was observed after (3)H-CBZ incubation with functionally reconstituted, purified recombinant CYP3A4(His)(6).	Histidine	162-165	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	54-60
18096676-8	2008	Similar binding (1.0 +/- 0.4 pmol (3)H-CBZ bound/pmol CYP3A4) was observed after (3)H-CBZ incubation with functionally reconstituted, purified recombinant CYP3A4(His)(6).	Histidine	162-165	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	155-161
18397775-2	2008	Here, we demonstrated the C-terminus-specific fluorescence labeling of histidine-tagged thrombopoietin (TPO), a ligand for Mpl, with desthiobiotin-tagged fluorescent puromycin.	Histidine	71-80	thrombopoietin	Homo sapiens	88-102
18397775-2	2008	Here, we demonstrated the C-terminus-specific fluorescence labeling of histidine-tagged thrombopoietin (TPO), a ligand for Mpl, with desthiobiotin-tagged fluorescent puromycin.	Histidine	71-80	thrombopoietin	Homo sapiens	104-107
18397775-2	2008	Here, we demonstrated the C-terminus-specific fluorescence labeling of histidine-tagged thrombopoietin (TPO), a ligand for Mpl, with desthiobiotin-tagged fluorescent puromycin.	Histidine	71-80	MPL proto-oncogene, thrombopoietin receptor	Homo sapiens	123-126
18004771-0	2008	Crystal structure of TTHA0303 (TT2238), a four-helix bundle protein with an exposed histidine triad from Thermus thermophilus HB8 at 2.0 A.	Histidine	84-93	DinB family protein	Thermus thermophilus HB8	21-29
18208382-2	2008	Analysis of the sequences and structures of influenza HA (haemagglutinin) and flaviviral envelope glycoproteins has led to the identification of a number of histidine residues that are not only fully conserved themselves but have local environments that are also highly conserved [Kampmann, Mueller, Mark, Young and Kobe (2006) Structure 14, 1481-1487].	Histidine	157-166	microtubule affinity regulating kinase 1	Homo sapiens	300-304
19704731-6	2008	Cloning of the STOP1 gene revealed that it encodes a Cys2/His2 zinc-finger type transcription factor, and a conserved His residue was replaced with Tyr in the predicted amino acid sequence for the mutant gene.	Histidine	58-61	C2H2 and C2HC zinc fingers superfamily protein	Arabidopsis thaliana	15-20
17970784-6	2008	Sonodynamically-induced apoptosis, caspase-3 activation, and nitroxide generation were significantly suppressed by histidine.	Histidine	115-124	caspase 3	Homo sapiens	35-44
19734126-4	2008	However, the combination of insulin +DTT + recombinant his-tagged ENOX2 (tNOX) did result in increased turbidity.	Histidine	55-58	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	66-71
19734126-4	2008	However, the combination of insulin +DTT + recombinant his-tagged ENOX2 (tNOX) did result in increased turbidity.	Histidine	55-58	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	73-77
17573222-8	2008	In the HI group, iNOS was present in neurons and macrophages of the cerebral cortex 12h after the insult.	Histidine	7-9	nitric oxide synthase 2	Sus scrofa	17-21
17931695-7	2008	The presence of PINCH (particularly interesting new Cys-His protein) and alpha-parvin, which constitute the IPP (ILK-PINCH-parvin) complex together with the integrin-linked kinase (ILK), has been predicted in platelets by proteomic analysis.	Histidine	56-59	integrin linked kinase	Homo sapiens	113-116
18473246-0	2008	Hb Jeddah [alpha68(E17)Asn-->His (alpha1)]: a newly recognized alpha chain variant, seen in combination with Hb S [beta6(A3)Glu-->Val], and found in three separate families of middle eastern origin.	Histidine	29-32	BCL2 related protein A1	Homo sapiens	34-40
18826058-5	2008	Using human tumor necrosis factor alpha as a model protein, we describe here the steps involved in the removal of a His-tag using TAGZyme.	Histidine	116-119	tumor necrosis factor	Homo sapiens	12-39
17959713-8	2008	Thus, we conclude that zinc and copper inhibition is due to a direct interaction of these divalent cations with ectodomain residues of the P2X(7) receptor, primarily involving combined interaction with His(62) and Asp(197) residues.	Histidine	202-205	purinergic receptor P2X 7	Homo sapiens	139-154
18085519-6	2008	The use of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) coupled with the (18)O-labeled internal standard approach has allowed us to show that (i) the N-domain of ACE (N-ACE), but not the C-domain, selectively cleaves the Arg-5-His-6 bond in both peptides, and that (ii) N-ACE hydrolyzes the isoAsp-7 analogue more efficiently than the non-modified one.	Histidine	273-276	angiotensin I converting enzyme	Homo sapiens	208-211
18985481-1	2008	BACKGROUND: The fragile histidine triad (FHIT) gene is abnormally expressed in many kinds of tumors and plays an important role in tumor development.	Histidine	24-33	fragile histidine triad gene	Mus musculus	41-45
18989812-6	2008	Our central idea was to inhibit the PLA(2) and Mel activities through histidine alkylation and or tryptophan oxidation (with pbb, para-bromo-phenacyl bromide, and/or NBS- N-bromosuccinimide, respectively) to make their encapsulations possible within stabilized liposomes.	Histidine	70-79	phospholipase A2 group IB	Homo sapiens	36-42
17602703-6	2007	She had a MPZ mutation with A-C transversion (nucleotide: 116, codon: 10, histidine-to-proline).	Histidine	74-83	myelin protein zero	Bos taurus	10-13
20641931-0	2004	(99m)Tc-pGlu-Gln-Trp-Ala-Val-Gly-His-Phe-Met-NH2 Bombesin (BBN or BN)-like peptide is an analog of human gastrin-releasing peptide (GRP) that binds to GRP receptors (GRP-R) (1).	Histidine	33-36	gastrin releasing peptide receptor	Homo sapiens	151-164
20641931-0	2004	(99m)Tc-pGlu-Gln-Trp-Ala-Val-Gly-His-Phe-Met-NH2 Bombesin (BBN or BN)-like peptide is an analog of human gastrin-releasing peptide (GRP) that binds to GRP receptors (GRP-R) (1).	Histidine	33-36	gastrin releasing peptide receptor	Homo sapiens	166-171
18035040-4	2007	The five cysteine residues of this region have been replaced with serine and histidine residues in the polypeptide CD4mut.	Histidine	77-86	CD4 molecule	Homo sapiens	115-121
17893515-7	2007	Both sonodynamically induced apoptosis and caspase-3 activation were significantly suppressed by histidine.	Histidine	97-106	caspase 3	Homo sapiens	43-52
18789788-3	2007	Concerning the serotonin 5-HT(2A) receptor gene, the frequency of allele tyrosine (versus histidine) at 452 was greater among nonresponders, and homozygosity for the cytosine allele at 102 was more frequent among nonresponders.	Histidine	90-99	5-hydroxytryptamine receptor 2A	Homo sapiens	15-42
17979301-2	2007	Cocrystal structures of PDE5 catalytic (C) domain with inhibitors reveal a hydrogen bond and hydrophobic interactions with Tyr-612, hydrogen bonds with Gln-817, a hydrophobic clamp formed by Phe-820 and Val-782, and contacts with His-613, Leu-765, and Phe-786 [Sung et al.	Histidine	230-233	phosphodiesterase 5A	Homo sapiens	24-28
17870088-15	2007	Taken together, these results imply that while Hint3 and Hint1 prefer aminoacyl-adenylates as substrates and catalytically interact with aminoacyl-tRNA synthetases, the significant differences in phosphoramidase activity, oligomeric state, and cellular localization suggest that Hint3s should be placed in a distinct branch of the histidine triad superfamily.	Histidine	331-340	histidine triad nucleotide binding protein 1	Homo sapiens	57-62
17893515-9	2007	Significant reduction by histidine in both sonodynamically induced apoptosis and caspase-3 activation suggests that some ultrasonically generated active species, deactivatable by histidine, are the major mediators to induce the observed apoptosis.	Histidine	25-34	caspase 3	Homo sapiens	81-90
17893515-9	2007	Significant reduction by histidine in both sonodynamically induced apoptosis and caspase-3 activation suggests that some ultrasonically generated active species, deactivatable by histidine, are the major mediators to induce the observed apoptosis.	Histidine	179-188	caspase 3	Homo sapiens	81-90
17359554-6	2007	In nasopharyngeal carcinoma, loss of heterozygosity at the FRA3B/fragile histidine triad locus correlated with the following clinicopathological parameters: tumour T-stage, lymph node status, clinical stage, tumour differentiation and serum antibody titres of immunoglobulin (Ig) A against Epstein-Barr virus capsid antigen.	Histidine	73-82	CD79a molecule	Homo sapiens	260-281
17905676-4	2007	In size-exclusion chromatography, purified full-length His(6)-tagged Bcl-x(L) migrated as both dimer and monomer, of which the monomeric fractions were used for experiments.	Histidine	55-58	BCL2 like 1	Homo sapiens	69-74
17883254-3	2007	The inhibition of H 2O 2-induced IL-8 secretion from Caco-2 cells was observed by pretreatment with Cys, Val, Ile, Leu, Trp, His, Lys, and Ala.	Histidine	125-128	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
17885091-6	2007	The AGP31 protein shares features with several known and putative nonclassical AGPs from other species: a putative signal peptide, a histidine-rich region near the N terminus followed by a repetitive proline-rich domain, and a cysteine-rich C-terminal PAC (for proline-rich protein and AGP, containing cysteine) domain.	Histidine	133-142	arabinogalactan protein 31	Arabidopsis thaliana	4-9
17850814-0	2007	ArgR-dependent repression of arginine and histidine transport genes in Escherichia coli K-12.	Histidine	42-51	arginine repressor	Escherichia coli	0-4
17716689-1	2007	The zinc finger domain of the Wilms tumor suppressor protein (WT1) contains four canonical Cys(2)His(2) zinc fingers.	Histidine	97-100	WT1 transcription factor	Homo sapiens	62-65
17655525-3	2007	H-Prune shows no sequence similarity with known mammalian PDEs, but instead appears to belong to the DHH (Asp-His-His) superfamily of phosphoesterases.	Histidine	110-113	desert hedgehog signaling molecule	Homo sapiens	101-104
17890955-0	2007	The role of ascorbate and histidine in fibrinogen protection against changes following exposure to a sterilizing dose of gamma-irradiation.	Histidine	26-35	fibrinogen beta chain	Homo sapiens	39-49
17890955-1	2007	Sodium ascorbate and histidine were employed to protect fibrinogen against modifications followed by a gamma-irradiation process that could potentially inactivate the blood-borne viruses in plasma-derived products.	Histidine	21-30	fibrinogen beta chain	Homo sapiens	56-66
17890955-8	2007	Contrary to ascorbate, which alone delayed the fibrinogen polymerization rate, histidine abolished irradiation-induced inhibition of fibrinogen polymerization (by 80% at 50 mmol/l; P &lt; 0.001).	Histidine	79-88	fibrinogen beta chain	Homo sapiens	133-143
17890955-10	2007	On the contrary, the first definite evidence is provided that radiation-sterilized fibrinogen in the presence of histidine greatly retains its clotting capability.	Histidine	113-122	fibrinogen beta chain	Homo sapiens	83-93
17702678-1	2007	The Arabidopsis MAP kinase 4 (MPK4) substrate MKS1 was expressed in Escherichia coli and purified, full-length, 6x histidine (His)-tagged MKS1 was phosphorylated in vitro by hemagglutinin (HA)-tagged MPK4 immuno-precipitated from plants.	Histidine	115-124	MAP kinase substrate 1	Arabidopsis thaliana	46-50
17969688-3	2007	To address this issue, volatile DBP formation resulting from the chlorination of four model compounds (creatinine, urea, L-histidine, and L-arginine) was investigated over a range of chlorine/precursor (Cl/P) molar ratios.	Histidine	121-132	D-box binding PAR bZIP transcription factor	Homo sapiens	32-35
17628687-5	2007	It was shown that the tripeptides with histidine in the third position formed CuH(-2)L species with (NH(2), 2N(-), ImN - where Im stands for imidazole) coordination sphere as a major species, and only the macrochelated CuL complexes as minor species around pH 5.0.	Histidine	39-48	cullin 2	Homo sapiens	219-222
17702678-1	2007	The Arabidopsis MAP kinase 4 (MPK4) substrate MKS1 was expressed in Escherichia coli and purified, full-length, 6x histidine (His)-tagged MKS1 was phosphorylated in vitro by hemagglutinin (HA)-tagged MPK4 immuno-precipitated from plants.	Histidine	115-124	MAP kinase substrate 1	Arabidopsis thaliana	138-142
17702678-1	2007	The Arabidopsis MAP kinase 4 (MPK4) substrate MKS1 was expressed in Escherichia coli and purified, full-length, 6x histidine (His)-tagged MKS1 was phosphorylated in vitro by hemagglutinin (HA)-tagged MPK4 immuno-precipitated from plants.	Histidine	126-129	MAP kinase substrate 1	Arabidopsis thaliana	46-50
17702678-1	2007	The Arabidopsis MAP kinase 4 (MPK4) substrate MKS1 was expressed in Escherichia coli and purified, full-length, 6x histidine (His)-tagged MKS1 was phosphorylated in vitro by hemagglutinin (HA)-tagged MPK4 immuno-precipitated from plants.	Histidine	126-129	MAP kinase substrate 1	Arabidopsis thaliana	138-142
17538006-10	2007	Molecular docking studies suggested that PSI2106 may interact with His(229) and Phe(299) on MKP-1.	Histidine	67-70	dual specificity phosphatase 1	Homo sapiens	92-97
17361366-7	2007	Also, the introduction of a short dipeptide (His-Arg) motif, a crucial component of the ag region, into different locations within the C-terminus of CFTR lead to changes in the aggregation pattern that were less striking, although still statistically significant.	Histidine	45-48	CF transmembrane conductance regulator	Homo sapiens	149-153
17587159-4	2007	Moreover, on SDS-polyacrylamide gel electrophoresis (SDS-PAGE) under nonreducing conditions, hexahistidine-tagged hGST P1-1 (His(6)-hGST P1-1) treated with 1 mM H(2)O(2) showed at least three extra bands, in addition to the native His(6)-hGST P1-1 subunit band.	Histidine	125-128	S100 calcium binding protein A10	Homo sapiens	119-123
17574631-6	2007	Colonic HIS was significantly affected (P&lt;0.05) in inoculated IL10(-/-) mice and accounted for approximately 60% of total intestinal HIS.	Histidine	8-11	interleukin 10	Mus musculus	65-69
17574631-11	2007	IL10(-/-) mice fed EPA- and AA-enriched diets had at least 40% lower colonic HIS (P&lt;0.05) than those fed control diets (AIN-76A and OA diets).	Histidine	77-80	interleukin 10	Mus musculus	0-4
17587159-4	2007	Moreover, on SDS-polyacrylamide gel electrophoresis (SDS-PAGE) under nonreducing conditions, hexahistidine-tagged hGST P1-1 (His(6)-hGST P1-1) treated with 1 mM H(2)O(2) showed at least three extra bands, in addition to the native His(6)-hGST P1-1 subunit band.	Histidine	231-234	S100 calcium binding protein A10	Homo sapiens	119-123
17613246-9	2007	The CD4 fragment was expressed in Escherichia coli C43(DE3) cells as a ubiquitin fusion with an N-terminal His-tag, isolated, released by PreScission proteolytic cleavage, and purified to homogeneity.	Histidine	107-110	CD4 molecule	Homo sapiens	4-7
17655328-6	2007	Histidines in Motif III, V, and the HST loop are also functionally important.	Histidine	0-10	histatin 3	Homo sapiens	36-39
17597065-7	2007	Substitution of Asp(177) to alanine increased nuclear localization of the construct in MEK1-overexpressing cells, suggesting that this residue together with His(176) is involved in the dissociation of ERK2 from MEKs.	Histidine	157-160	mitogen-activated protein kinase 1	Homo sapiens	201-205
17655328-8	2007	Proximity and orientation of this Glu side chain relative to His in the HST loop and the importance of both residues for catalysis suggest that they function as a duo in proton transfer at the final stage of reaction, characteristic of the tRNase Z class of RNA endonucleases.	Histidine	61-64	histatin 3	Homo sapiens	72-75
17675514-2	2007	Recombinant histidine-tagged FPR (rHis-FPR) was purified in lysophosphatidyl glycerol (LPG) by Ni(2+)-NTA agarose chromatography to &gt;95% purity with high yield.	Histidine	12-21	formyl peptide receptor 1	Homo sapiens	29-32
17658762-6	2007	These adducts could have significant effects considering that His-33, Lys-72, and Lys-100 are present in clusters of basic amino acid residues, which are believed to participate in the interaction of cytochrome c with cardiolipin in the inner mitochondrial membrane and cytochrome c oxidase.	Histidine	62-65	cytochrome c, somatic	Homo sapiens	200-212
17658762-6	2007	These adducts could have significant effects considering that His-33, Lys-72, and Lys-100 are present in clusters of basic amino acid residues, which are believed to participate in the interaction of cytochrome c with cardiolipin in the inner mitochondrial membrane and cytochrome c oxidase.	Histidine	62-65	cytochrome c, somatic	Homo sapiens	270-282
17313372-0	2007	One-step purification of histidine-tagged profilin with high purity and yield by using metal precipitation.	Histidine	25-34	profilin	Cucumis melo	42-50
17313372-1	2007	A simple one-step method for the purification of recombinant His-tagged profilin from the bacterial cell lysate is reported.	Histidine	61-64	profilin	Cucumis melo	72-80
17675514-2	2007	Recombinant histidine-tagged FPR (rHis-FPR) was purified in lysophosphatidyl glycerol (LPG) by Ni(2+)-NTA agarose chromatography to &gt;95% purity with high yield.	Histidine	12-21	formyl peptide receptor 1	Homo sapiens	39-42
17669278-1	2007	An Asp/His catalytic site of 10-formyltetrahydrofolate dehydrogenase (FDH) was suggested to have a similar catalytic topology with the Asp/His catalytic site of serine proteases.	Histidine	7-10	aldehyde dehydrogenase 1 family, member L1	Rattus norvegicus	29-68
17617795-4	2007	The wild type sequence of PTH(1-11) is H-Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-NH(2).	Histidine	73-76	parathyroid hormone	Homo sapiens	26-29
17669278-1	2007	An Asp/His catalytic site of 10-formyltetrahydrofolate dehydrogenase (FDH) was suggested to have a similar catalytic topology with the Asp/His catalytic site of serine proteases.	Histidine	7-10	aldehyde dehydrogenase 1 family, member L1	Rattus norvegicus	70-73
17669278-1	2007	An Asp/His catalytic site of 10-formyltetrahydrofolate dehydrogenase (FDH) was suggested to have a similar catalytic topology with the Asp/His catalytic site of serine proteases.	Histidine	139-142	aldehyde dehydrogenase 1 family, member L1	Rattus norvegicus	29-68
17652174-5	2007	A model for the donor of PS2 is presented explaining the inversion of electron spin density based on a tilt of the axial histidine toward pyrrole ring IV causing pi-pi overlap of both aromatic systems.	Histidine	121-130	taste 2 receptor member 64 pseudogene	Homo sapiens	25-28
17669278-1	2007	An Asp/His catalytic site of 10-formyltetrahydrofolate dehydrogenase (FDH) was suggested to have a similar catalytic topology with the Asp/His catalytic site of serine proteases.	Histidine	139-142	aldehyde dehydrogenase 1 family, member L1	Rattus norvegicus	70-73
17616248-0	2007	Enzyme-linked immunosorbent assays for insulin-like growth factor-I using six-histidine tag fused proteins.	Histidine	78-87	insulin like growth factor 1	Homo sapiens	39-67
17545153-7	2007	Further mutagenesis studies indicate that conserved residues Glu(100) in TM2, Asp(122), Asp(126) in TM3 and Trp(258), Phe(261), His(264) in TM6 are involved in alpha-MSH binding and signaling.	Histidine	128-131	proopiomelanocortin	Homo sapiens	160-169
17616248-1	2007	The fusion proteins of insulin-like growth factor-I (IGF-I) and six-histidine tag (IGF-I-6H, 6H-IGF-I-6H) were cloned, expressed, purified and renatured, with their immunoreaction properties and biological activities intact.	Histidine	68-77	insulin like growth factor 1	Homo sapiens	83-88
17616248-1	2007	The fusion proteins of insulin-like growth factor-I (IGF-I) and six-histidine tag (IGF-I-6H, 6H-IGF-I-6H) were cloned, expressed, purified and renatured, with their immunoreaction properties and biological activities intact.	Histidine	68-77	insulin like growth factor 1	Homo sapiens	83-88
17616248-3	2007	Two enzyme-linked immunosorbent assay (ELISA) modes, which proved feasible in the measurement of human serum samples, were used to detect IGF-I with the help of the six-histidine tagged proteins.	Histidine	169-178	insulin like growth factor 1	Homo sapiens	138-143
17536841-8	2007	These findings were further supported by the observation that DYRK1A retained significant enzymatic activity when both tyrosine residues in the YXY motif were replaced with either histidine or glutamine.	Histidine	180-189	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	62-68
17499207-12	2007	The Asp380 amino acid residue appears to be important in myocilin function based on the finding that substitution of this amino acid with four different amino acids (His, Ala, Asn, or Gly) all result in a similar presentation of POAG that is intermediate between the more severe clinical presentations observed in individuals with the Pro370Leu or Lys423Glu variant and the milder findings in patients with the Gln368Stop mutation.	Histidine	166-169	myocilin	Homo sapiens	57-65
17427958-1	2007	We report the X-ray crystal structures and rate constants for proton transfer in site-specific mutants of human carbonic anhydrase III (HCA III) that place a histidine residue in the active-site cavity: K64H, R67H, and K64H-R67N HCA III.	Histidine	158-167	carbonic anhydrase 3	Homo sapiens	112-134
17596760-1	2007	OBJECTIVE: This cross-sectional study was intended to assess the association between immunohistochemical analysis of p16 and fragile histidine triad (FHIT) and the presence of precancerous cervical lesions.	Histidine	133-142	cyclin dependent kinase inhibitor 2A	Homo sapiens	117-120
17317218-9	2007	Attempts to further purify His-tagged RGL-3 using Ni/NTA chromatography resulted in the formation of higher polymers.	Histidine	27-30	RGA-like protein 3	Arabidopsis thaliana	38-43
17327464-7	2007	The transport of TEA via rMATE1 was inhibited by the sulfhydryl reagent p-chloromercuribenzenesulfonate (PCMBS) and the histidine residue modifier diethyl pyrocarbonate (DEPC) in a concentration-dependent manner.	Histidine	120-129	solute carrier family 47 member 1	Rattus norvegicus	25-31
17327464-10	2007	These results suggest that histidine and cysteine residues are required for MATE1 to function and that cysteine residues may serve as substrate-recognition sites.	Histidine	27-36	solute carrier family 47 member 1	Rattus norvegicus	76-81
17516928-5	2007	Sequence analysis of Edn3 identified a G &gt; A transversion that encodes an arginine to histidine substitution (R96H).	Histidine	89-98	endothelin 3	Mus musculus	21-25
17503777-8	2007	Sco1, a distantly related thioredoxin-fold protein, has histidine in place of the cis-proline, and this residue binds copper.	Histidine	56-65	synthesis of cytochrome C oxidase 1	Homo sapiens	0-4
17330862-5	2007	The dependence of the transition temperature on the pH indicates a role for histidine residues in the destabilization of the cyt c structure in the PVS complex and in stabilization of the denatured state with the residual secondary structure.	Histidine	76-85	cytochrome c, somatic	Homo sapiens	125-130
17562266-2	2007	Abnormality of the fragile histidine triad (FHIT) gene has been proved to closely relate to lung cancer development.	Histidine	27-36	fragile histidine triad diadenosine triphosphatase	Rattus norvegicus	44-48
17327464-3	2007	In the present study, essential histidine and cysteine residues of MATE1 family were elucidated.	Histidine	32-41	solute carrier family 47 member 1	Rattus norvegicus	67-72
17327464-4	2007	When 7 histidine and 12 cysteine residues of rat (r)MATE1 conserved among species were mutated, substitution of His-385, Cys-62, and Cys-126 led to a significant loss of tetraethylammonium (TEA) transport activity.	Histidine	7-16	solute carrier family 47 member 1	Rattus norvegicus	52-57
17327464-4	2007	When 7 histidine and 12 cysteine residues of rat (r)MATE1 conserved among species were mutated, substitution of His-385, Cys-62, and Cys-126 led to a significant loss of tetraethylammonium (TEA) transport activity.	Histidine	112-115	solute carrier family 47 member 1	Rattus norvegicus	52-57
17498272-4	2007	On the other hand, sequence analysis of exons 2 and 3 for HLA-A*2471 showed a single substitution, leading to a single amino acid change at position 151 (His --&gt; Arg).	Histidine	154-157	major histocompatibility complex, class I, A	Homo sapiens	58-68
17206692-6	2007	In UC patients the apoA-IV gene variant 360 His (P = 0.03) but not apoA-IV levels (P = 0.15) were associated with increased disease activity in univariate analysis.	Histidine	44-47	apolipoprotein A4	Homo sapiens	19-26
17469798-0	2007	Histidine 282 in 5-aminolevulinate synthase affects substrate binding and catalysis.	Histidine	0-9	5'-aminolevulinate synthase 1	Homo sapiens	17-43
17469798-3	2007	In ALAS, replacing the equivalent histidine, H282, with alanine reduces the catalytic efficiency for glycine 450-fold and decreases the slow phase rate for glycine binding by 85%.	Histidine	34-43	5'-aminolevulinate synthase 1	Homo sapiens	3-7
17293598-4	2007	We show now that His-384, corresponding to the risk allele, binds C-reactive protein (CRP) poorly compared with the Tyr-384 form.	Histidine	17-20	C-reactive protein	Homo sapiens	66-84
17293598-4	2007	We show now that His-384, corresponding to the risk allele, binds C-reactive protein (CRP) poorly compared with the Tyr-384 form.	Histidine	17-20	C-reactive protein	Homo sapiens	86-89
17511607-1	2007	The gene of human interleukin-6 (hIL-6) with an additional 20 amino acids on the N-end, including six histidine residues, was cloned into the expression plasmid pET28b(+).	Histidine	102-111	interleukin 6	Homo sapiens	18-31
17511607-1	2007	The gene of human interleukin-6 (hIL-6) with an additional 20 amino acids on the N-end, including six histidine residues, was cloned into the expression plasmid pET28b(+).	Histidine	102-111	interleukin 6	Homo sapiens	33-38
17495930-5	2007	Structural and biochemical evidence reveals that Sdp1 employs an intramolecular disulphide bridge and an invariant histidine side chain to selectively recognize a tyrosine-phosphorylated MAPK substrate.	Histidine	115-124	mitogen-activated protein kinase tyrosine protein phosphatase SDP1	Saccharomyces cerevisiae S288C	49-53
17510397-1	2007	There is accumulating evidence that histidine triad (HIT) nucleotide-binding protein 1 (HINT1), a member of the evolutionary highly conserved HIT protein super family, is a novel tumor suppressor.	Histidine	36-45	histidine triad nucleotide binding protein 1	Homo sapiens	88-93
18690027-4	2007	We demonstrate here that the mouse RIM1 arginine-to-histidine substitution (R655H), which corresponds to the human CORD7 mutation, modifies RIM1 function in regulating VDCC currents elicited by the P/Q-type Ca(v)2.1 and L-type Ca(v)1.4 channels.	Histidine	52-61	regulating synaptic membrane exocytosis 1	Mus musculus	35-39
17301132-9	2007	Codons for methionine, lysine, histidine, or glutamic acid are found prior to the Gag-Pol frameshift site.	Histidine	31-40	Gag-Pol	Human immunodeficiency virus 1	82-89
17873334-2	2007	It is caused by embryonic somatic mutations leading to the substitution of His or Cys for Arg at amino acid 201 of the alpha-subunit of the signal transduction protein Gs (Gsalpha).	Histidine	75-78	GNAS complex locus	Homo sapiens	172-179
17289077-5	2007	One site is the regulatory histidine-rich domain that interacts with CDK9 substrates including RNA polymerase II.	Histidine	27-36	cyclin dependent kinase 9	Homo sapiens	69-73
17207559-4	2007	Histidine(4), tyrosine(5), tryptophan(6), histidine(7)-TIP39 binds the PTH2 receptor with high affinity, has over 30-fold selectivity for the rat PTH2 receptor over the rat PTH1 receptor and displays no detectable agonist activity.	Histidine	42-51	parathyroid hormone 2	Rattus norvegicus	55-60
17227754-9	2007	The catalytic function of HS-2OST appears to involve two histidine residues (His140 and His142), whereas only one histidine (His168) of CS 2-OST is likely to be critical.	Histidine	57-66	Heparan sulfate 2-O-sulfotransferase	Drosophila melanogaster	26-33
17309234-4	2007	By using various techniques including native-PAGE, EPR, UV-visible electronic absorption, intrinsic fluorescence spectroscopies as well as DEPC modification of histidines, we demonstrate that COMMD1 specifically binds copper as Cu(II) in 1:1 stoichiometry and does not bind other divalent metals.	Histidine	160-170	copper metabolism domain containing 1	Homo sapiens	192-198
16956964-1	2007	In Kv1.5, protonation of histidine 463 in the S5-P linker (turret) increases the rate of depolarization-induced inactivation and decreases the peak current amplitude.	Histidine	25-34	potassium voltage-gated channel subfamily A member 5	Homo sapiens	3-8
17342260-1	2007	The aim of this study is to construct a lentiviral expression vector containing a scavenger receptor (SR-PSOX) that binds with uniquely phosphatidylserine and oxidized lipoprotein with six histidine tags and to investigate the function of SR-PSOX in atherosclerosis.	Histidine	189-198	C-X-C motif chemokine ligand 16	Homo sapiens	102-109
17158446-7	2007	Site-directed mutagenesis studies of the active site histidine triad revealed that Hint labeling could be abolished by substitution of either His-101 of E. coli hinT or His-112 of human Hint1 by either alanine or glycine.	Histidine	53-62	histidine triad nucleotide binding protein 1	Homo sapiens	161-165
17164404-11	2007	These novel results show that the formation of 4-HNE-Erk-1/2 monomer-adducts results in the inhibition of Erk-Elk-AP-1 signaling in hepatocytes and implicates the His 178 residue with the mechanism of inhibition.	Histidine	163-166	Eph receptor B1	Rattus norvegicus	53-56
17348731-4	2007	The central His-Phe-Arg-Trp tetrapeptide sequence of alpha-MSH is known to form a turn in the bioactive conformation.	Histidine	12-15	proopiomelanocortin	Homo sapiens	53-62
17119851-9	2007	Kinetic studies using the peptides pGlu-His-Pro-NH(2) (TRH), pGlu-Ala and pGlu-Val revealed K (i) values of 44.1, 141 and 652.17 microM, respectively.	Histidine	40-43	thyrotropin releasing hormone	Bos taurus	55-58
17166829-7	2007	In contrast, we found that CBP intrinsic activity was increased by Akt through threonine 1872, a consensus site for Akt in the cysteine- and histidine-rich 3 domain of CBP, indicating that such enhanced transcriptional potential of CBP did not serve to activate ERbeta.	Histidine	141-150	CREB binding protein	Homo sapiens	27-30
17158446-7	2007	Site-directed mutagenesis studies of the active site histidine triad revealed that Hint labeling could be abolished by substitution of either His-101 of E. coli hinT or His-112 of human Hint1 by either alanine or glycine.	Histidine	53-62	histidine triad nucleotide binding protein 1	Homo sapiens	186-191
17166829-7	2007	In contrast, we found that CBP intrinsic activity was increased by Akt through threonine 1872, a consensus site for Akt in the cysteine- and histidine-rich 3 domain of CBP, indicating that such enhanced transcriptional potential of CBP did not serve to activate ERbeta.	Histidine	141-150	AKT serine/threonine kinase 1	Homo sapiens	67-70
17166829-7	2007	In contrast, we found that CBP intrinsic activity was increased by Akt through threonine 1872, a consensus site for Akt in the cysteine- and histidine-rich 3 domain of CBP, indicating that such enhanced transcriptional potential of CBP did not serve to activate ERbeta.	Histidine	141-150	AKT serine/threonine kinase 1	Homo sapiens	116-119
17158446-0	2007	Lysyl-tRNA synthetase-generated lysyl-adenylate is a substrate for histidine triad nucleotide binding proteins.	Histidine	67-76	lysyl-tRNA synthetase 1	Homo sapiens	0-21
17158446-7	2007	Site-directed mutagenesis studies of the active site histidine triad revealed that Hint labeling could be abolished by substitution of either His-101 of E. coli hinT or His-112 of human Hint1 by either alanine or glycine.	Histidine	142-145	histidine triad nucleotide binding protein 1	Homo sapiens	83-87
17158446-7	2007	Site-directed mutagenesis studies of the active site histidine triad revealed that Hint labeling could be abolished by substitution of either His-101 of E. coli hinT or His-112 of human Hint1 by either alanine or glycine.	Histidine	53-62	histidine triad nucleotide binding protein 1	Homo sapiens	83-87
17166829-7	2007	In contrast, we found that CBP intrinsic activity was increased by Akt through threonine 1872, a consensus site for Akt in the cysteine- and histidine-rich 3 domain of CBP, indicating that such enhanced transcriptional potential of CBP did not serve to activate ERbeta.	Histidine	141-150	CREB binding protein	Homo sapiens	168-171
17166829-7	2007	In contrast, we found that CBP intrinsic activity was increased by Akt through threonine 1872, a consensus site for Akt in the cysteine- and histidine-rich 3 domain of CBP, indicating that such enhanced transcriptional potential of CBP did not serve to activate ERbeta.	Histidine	141-150	CREB binding protein	Homo sapiens	168-171
17158446-7	2007	Site-directed mutagenesis studies of the active site histidine triad revealed that Hint labeling could be abolished by substitution of either His-101 of E. coli hinT or His-112 of human Hint1 by either alanine or glycine.	Histidine	142-145	histidine triad nucleotide binding protein 1	Homo sapiens	161-165
17158446-7	2007	Site-directed mutagenesis studies of the active site histidine triad revealed that Hint labeling could be abolished by substitution of either His-101 of E. coli hinT or His-112 of human Hint1 by either alanine or glycine.	Histidine	142-145	histidine triad nucleotide binding protein 1	Homo sapiens	186-191
17158446-7	2007	Site-directed mutagenesis studies of the active site histidine triad revealed that Hint labeling could be abolished by substitution of either His-101 of E. coli hinT or His-112 of human Hint1 by either alanine or glycine.	Histidine	169-172	histidine triad nucleotide binding protein 1	Homo sapiens	83-87
17158446-7	2007	Site-directed mutagenesis studies of the active site histidine triad revealed that Hint labeling could be abolished by substitution of either His-101 of E. coli hinT or His-112 of human Hint1 by either alanine or glycine.	Histidine	169-172	histidine triad nucleotide binding protein 1	Homo sapiens	186-191
17187755-4	2007	To partially address this question, we have mutated the histidine residue in H-loop of MRP1 to either a residue that prevents the formation of hydrogen-bonds with ATP and other residues in MRP1 or a residue that may potentially form these hydrogen-bonds.	Histidine	56-65	ATP binding cassette subfamily C member 1	Homo sapiens	87-91
17279625-2	2007	The protein Required for Mla12 Resistance (RAR1) is a component of such pathways, which contains cysteine- and histidine-rich domains (CHORDs) that bind zinc.	Histidine	111-120	cysteine and histidine-rich domain-containing protein RAR1	Arabidopsis thaliana	43-47
17261087-3	2007	Mutant angiotensinogens in which the Ile-His-Pro-Phe-His-Leu sequence at positions 5-10 of wild-type angiotensinogen was replaced by either His-Pro-Phe-His-Leu-Leu or Ala-Ile-His-Pro-Phe-His were cleaved by renin at the C-terminal side of residues 9 and 11, respectively, while wild-type angiotensinogen was cleaved at residue 10.	Histidine	53-56	angiotensinogen	Homo sapiens	7-22
17187755-4	2007	To partially address this question, we have mutated the histidine residue in H-loop of MRP1 to either a residue that prevents the formation of hydrogen-bonds with ATP and other residues in MRP1 or a residue that may potentially form these hydrogen-bonds.	Histidine	56-65	ATP binding cassette subfamily C member 1	Homo sapiens	189-193
17261087-0	2007	The His-Pro-Phe motif of angiotensinogen is a crucial determinant of the substrate specificity of renin.	Histidine	4-7	angiotensinogen	Homo sapiens	25-40
17261087-3	2007	Mutant angiotensinogens in which the Ile-His-Pro-Phe-His-Leu sequence at positions 5-10 of wild-type angiotensinogen was replaced by either His-Pro-Phe-His-Leu-Leu or Ala-Ile-His-Pro-Phe-His were cleaved by renin at the C-terminal side of residues 9 and 11, respectively, while wild-type angiotensinogen was cleaved at residue 10.	Histidine	53-56	angiotensinogen	Homo sapiens	7-22
17261087-0	2007	The His-Pro-Phe motif of angiotensinogen is a crucial determinant of the substrate specificity of renin.	Histidine	4-7	renin	Homo sapiens	98-103
17261087-1	2007	The amino acid sequence His-Pro-Phe as N-terminal residues 6-8 of the natural renin substrate, angiotensinogen, is conserved among species.	Histidine	24-27	renin	Homo sapiens	78-83
17261087-1	2007	The amino acid sequence His-Pro-Phe as N-terminal residues 6-8 of the natural renin substrate, angiotensinogen, is conserved among species.	Histidine	24-27	angiotensinogen	Homo sapiens	95-110
17261087-2	2007	We investigated whether this His-Pro-Phe motif functions as the determinant of the substrate specificity of renin.	Histidine	29-32	renin	Homo sapiens	108-113
17261087-3	2007	Mutant angiotensinogens in which the Ile-His-Pro-Phe-His-Leu sequence at positions 5-10 of wild-type angiotensinogen was replaced by either His-Pro-Phe-His-Leu-Leu or Ala-Ile-His-Pro-Phe-His were cleaved by renin at the C-terminal side of residues 9 and 11, respectively, while wild-type angiotensinogen was cleaved at residue 10.	Histidine	53-56	angiotensinogen	Homo sapiens	7-22
17261087-3	2007	Mutant angiotensinogens in which the Ile-His-Pro-Phe-His-Leu sequence at positions 5-10 of wild-type angiotensinogen was replaced by either His-Pro-Phe-His-Leu-Leu or Ala-Ile-His-Pro-Phe-His were cleaved by renin at the C-terminal side of residues 9 and 11, respectively, while wild-type angiotensinogen was cleaved at residue 10.	Histidine	41-44	angiotensinogen	Homo sapiens	7-22
17261087-3	2007	Mutant angiotensinogens in which the Ile-His-Pro-Phe-His-Leu sequence at positions 5-10 of wild-type angiotensinogen was replaced by either His-Pro-Phe-His-Leu-Leu or Ala-Ile-His-Pro-Phe-His were cleaved by renin at the C-terminal side of residues 9 and 11, respectively, while wild-type angiotensinogen was cleaved at residue 10.	Histidine	53-56	angiotensinogen	Homo sapiens	7-22
17261087-4	2007	A triple Ala substitution for the His-Pro-Phe motif of angiotensinogen prevented its cleavage by renin.	Histidine	34-37	angiotensinogen	Homo sapiens	55-70
17261087-4	2007	A triple Ala substitution for the His-Pro-Phe motif of angiotensinogen prevented its cleavage by renin.	Histidine	34-37	renin	Homo sapiens	97-102
17261087-6	2007	Furthermore, the 33-residue C-terminal peptide of human megsin, which carries a naturally occurring His-Pro-Phe sequence, was cleaved by renin at the C-terminal side of the His-Pro-Phe-Leu-Phe sequence.	Histidine	100-103	serpin family B member 7	Homo sapiens	56-62
17261087-6	2007	Furthermore, the 33-residue C-terminal peptide of human megsin, which carries a naturally occurring His-Pro-Phe sequence, was cleaved by renin at the C-terminal side of the His-Pro-Phe-Leu-Phe sequence.	Histidine	100-103	renin	Homo sapiens	137-142
17261087-6	2007	Furthermore, the 33-residue C-terminal peptide of human megsin, which carries a naturally occurring His-Pro-Phe sequence, was cleaved by renin at the C-terminal side of the His-Pro-Phe-Leu-Phe sequence.	Histidine	173-176	serpin family B member 7	Homo sapiens	56-62
17261087-6	2007	Furthermore, the 33-residue C-terminal peptide of human megsin, which carries a naturally occurring His-Pro-Phe sequence, was cleaved by renin at the C-terminal side of the His-Pro-Phe-Leu-Phe sequence.	Histidine	173-176	renin	Homo sapiens	137-142
17261087-7	2007	These results indicate that the His-Pro-Phe motif of angiotensinogen is a crucial determinant of the substrate specificity of renin.	Histidine	32-35	angiotensinogen	Homo sapiens	53-68
17261087-7	2007	These results indicate that the His-Pro-Phe motif of angiotensinogen is a crucial determinant of the substrate specificity of renin.	Histidine	32-35	renin	Homo sapiens	126-131
17261087-8	2007	By binding to a corresponding pocket on renin, the His-Pro-Phe motif may act as a molecular anchor to recruit the scissile peptide bond to a favorable site for catalysis.	Histidine	51-54	renin	Homo sapiens	40-45
17108049-6	2007	Similar to the case for the Escherichia coli and human UNG enzymes, His-BKRF3 excised uracil from single-stranded DNA more efficiently than from double-stranded DNA and was inhibited by the purified bacteriophage PBS1 inhibitor Ugi.	Histidine	68-71	uracil DNA glycosylase	Homo sapiens	55-58
17145192-5	2007	gACE was potently inhibited by EDTA, 1,10-phenanthroline, captopril and lisinopril, and it promptly released the dipeptides His-Leu and Phe-Arg from angiotensin I and bradykinin.	Histidine	124-127	angiotensinogen	Homo sapiens	149-162
17012384-0	2007	The plasminogen-binding group A streptococcal M protein-related protein Prp binds plasminogen via arginine and histidine residues.	Histidine	111-120	prion protein	Homo sapiens	72-75
17012384-8	2007	Furthermore, mutagenesis of Arg(107) and His(108) abolished plasminogen binding by Prp despite the presence of Lys(96) and Lys(101) in the binding site.	Histidine	41-44	prion protein	Homo sapiens	83-86
17013614-0	2007	Ab initio modelling of the structure and redox behaviour of copper(I) bound to a His-His model peptide: relevance to the beta-amyloid peptide of Alzheimer"s disease.	Histidine	81-84	amyloid beta precursor protein	Homo sapiens	121-141
17180725-7	2007	The optimal binding ratio his-tag GFP and his-tag Gag p24 to Ni-NPs was found to be 1:33.7 and 1:35.4 w/w, respectively.	Histidine	42-45	cytochrome P450, family 2, subfamily b, polypeptide 10	Mus musculus	54-57
17180725-9	2007	The in vivo studies demonstrated enhanced serum IgG and IgG2a responses to his-tag Gag p24 bound to Ni-NPs compared to protein adjuvanted with Alum or adsorbed on the surface of control NTA-NPs.	Histidine	75-78	cytochrome P450, family 2, subfamily b, polypeptide 10	Mus musculus	87-90
17202182-2	2007	The histidyl-aspartyl (His-Asp) phosphorelay mediates the signal from cytokinin receptors to type-B response regulators including ARR1, which transactivate cytokinin primary response genes.	Histidine	23-26	arrestin beta 1	Homo sapiens	130-134
17309094-3	2007	In this study, as demonstrated in a ligand screening for the histidine-tagged SH3 domain of the human phosphatidylinositol 3-kinase p85alpha subunit, false responses after adhesion of undesirable compounds to a target protein could be minimized with the NTA strategy, while binding responses of a positive control peptide still stayed within a 1%-deviation against the theoretical binding capacity.	Histidine	61-70	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	132-140
17202182-8	2007	These results provide novel evidence indicating that the His-Asp phosphorelay is connected to diverse regulatory levels of cytokinin-responsive phenomena through ARR1 direct-target genes.	Histidine	57-60	arrestin beta 1	Homo sapiens	162-166
16973378-3	2007	The histidine tag was removed from the human enzyme by thrombin digestion and the adenylosuccinate lyase was purified by Sephadex G-100 gel filtration.	Histidine	4-13	coagulation factor II, thrombin	Homo sapiens	55-63
17197512-3	2007	METHODS: HCE-T cells were incubated without or with the recombinant histidine-tagged Tbeta(4) produced by Escherichia coli before the addition of FasL or H(2)O(2).	Histidine	68-77	thymosin beta 4 X-linked	Homo sapiens	85-93
17244493-0	2007	Protective effects of histidine dipeptides on the modification of neurofilament-L by the cytochrome c/hydrogen peroxide system.	Histidine	22-31	cytochrome c, somatic	Homo sapiens	89-101
17244493-4	2007	In the present study, we investigated whether histidine dipeptides, carnosine, homocarnosine, or anserine protect NF-L against oxidative modification during reaction between cytochrome c and H(2)O(2).	Histidine	46-55	cytochrome c, somatic	Homo sapiens	174-186
17518591-0	2007	Monocytic U937 adhesion, tumor necrosis factor-alpha and interleukin-1 beta expression in response to gelatin-based networks grafted with arginine-glycine-aspartic acid and proline-histidine-serine-arginine-asparagine oligopeptides.	Histidine	181-190	interleukin 1 beta	Homo sapiens	57-75
17068338-4	2006	Compared with other ABC transporters, the first nucleotide binding site contains non-consensus catalytic site residues, including Asp(668) in the Walker B region of TAP1 (in place of a highly conserved glutamic acid), and Gln(701) in the switch region of TAP1 (in place of a highly conserved histidine).	Histidine	292-301	transporter 1, ATP binding cassette subfamily B member	Homo sapiens	165-169
17081490-3	2006	We report strikingly variable immunodetection of two His-tagged recombinant human erythropoietins (Epo): wild type Epo (Epo(wt)) and Epo containing an R103A mutation (Epo(R103A)).	Histidine	53-56	erythropoietin	Homo sapiens	99-102
17140194-1	2006	We describe detailed studies of peptide-sandwiched mesohemes PSMA and PSMW, which comprise two histidine (His)-containing peptides covalently attached to the propionate groups of iron mesoporphyrin II.	Histidine	95-104	folate hydrolase 1	Homo sapiens	61-65
17027028-2	2006	Photoconversion between the Pr and Pfr forms facilitates autophosphorylation of a histidine in the dimerization domain (DHp).	Histidine	82-91	dihydropyrimidinase	Homo sapiens	120-123
17140194-1	2006	We describe detailed studies of peptide-sandwiched mesohemes PSMA and PSMW, which comprise two histidine (His)-containing peptides covalently attached to the propionate groups of iron mesoporphyrin II.	Histidine	106-109	folate hydrolase 1	Homo sapiens	61-65
17140194-3	2006	Replacing an alanine residue in each peptide of PSMA with tryptophan (Trp) to give PSMW generates additional energy via Trp side chain-porphyrin interactions, which enhances the peptide helicity and stability of the His-ligated state.	Histidine	216-219	folate hydrolase 1	Homo sapiens	48-52
17157250-0	2006	Histidine phosphorylation of the potassium channel KCa3.1 by nucleoside diphosphate kinase B is required for activation of KCa3.1 and CD4 T cells.	Histidine	0-9	CD4 molecule	Homo sapiens	134-137
16872275-5	2006	Histidine residues within the unique N-terminal extension of AGT appear to influence polymer formation, although polymer formation can still take place after their removal by renin.	Histidine	0-9	angiotensinogen	Homo sapiens	61-64
17070916-6	2006	In sum, the current results establish that heme propionate esterification not only affects the electron transfer properties of myoglobin but also influences the titration behavior of specific His residues.	Histidine	192-195	myoglobin	Equus caballus	127-136
17105188-4	2006	The +2 phosphate group interacts directly with an active site histidine (H148 in humans) in the crystal structure of UDG in complex with double-stranded (ds) DNA.	Histidine	62-71	uracil DNA glycosylase	Homo sapiens	117-120
16872275-5	2006	Histidine residues within the unique N-terminal extension of AGT appear to influence polymer formation, although polymer formation can still take place after their removal by renin.	Histidine	0-9	renin	Homo sapiens	175-180
16840538-5	2006	The carboxy-terminal cysteine-histidine rich domain 3 of CBP, rather than its amino-terminal nuclear interacting domain, shown previously to mediate agonist-dependent interactions of CBP with nuclear receptors, is required for binding to ICI-liganded ERalpha.	Histidine	30-39	CREB binding protein	Homo sapiens	57-60
17001711-1	2006	In the completion of our fluorine scan of tricyclic inhibitors to map the fluorophilicity/fluorophobicity of the thrombin active site, a series of 11 new ligands featuring alkyl, alkenyl, and fluoroalkyl groups was prepared to explore fluorine effects on binding into the hydrophobic proximal (P) pocket, lined by Tyr 60A and Trp 60D, His 57, and Leu 99.	Histidine	335-338	coagulation factor II, thrombin	Homo sapiens	113-121
17048273-0	2006	The conserved histidine 166 residue of the human neonatal Fc receptor heavy chain is critical for the pH-dependent binding to albumin.	Histidine	14-23	Fc gamma receptor and transporter	Homo sapiens	49-69
17048273-3	2006	The FcRn-IgG interaction has been extensively characterized at the amino acid level and shown to depend on conserved histidine residues in the IgG-Fc part that interact with negatively charged residues in the alpha-2 domain of FcRn.	Histidine	117-126	Fc gamma receptor and transporter	Homo sapiens	4-8
17048273-3	2006	The FcRn-IgG interaction has been extensively characterized at the amino acid level and shown to depend on conserved histidine residues in the IgG-Fc part that interact with negatively charged residues in the alpha-2 domain of FcRn.	Histidine	117-126	Fc gamma receptor and transporter	Homo sapiens	227-231
16908518-4	2006	We report that Smad10 is a mutant form of Smad4beta that harbors a missense mutation of a conserved arginine to histidine in the MH1 domain.	Histidine	112-121	SMAD family member 4, gene 2 L homeolog	Xenopus laevis	15-21
17085975-7	2006	When cytochrome c that had been exposed to H2O2 was analyzed by amino acid analysis, the tyrosine, histidine and methionine residues proved to be particularly sensitive.	Histidine	99-108	cytochrome c, somatic	Homo sapiens	5-17
16797105-6	2006	Inhibition of thrombin, amounting to a 63.3% and 36.7% reduction in the rate of fibrin formation, was noted for cyclo(His-Ala) and cyclo(His-Gly), respectively.	Histidine	118-121	coagulation factor II, thrombin	Homo sapiens	14-22
16797105-6	2006	Inhibition of thrombin, amounting to a 63.3% and 36.7% reduction in the rate of fibrin formation, was noted for cyclo(His-Ala) and cyclo(His-Gly), respectively.	Histidine	137-140	coagulation factor II, thrombin	Homo sapiens	14-22
17037929-1	2006	We have proposed novel surface-imprinted beads for selective separation of cytochrome c (cyt c) by N-methacryloyl-(L)-histidine-copper(II) [MAH-Cu(II)] as a new metal-chelating monomer via metal coordination interactions and histidine template.	Histidine	118-127	cytochrome c, somatic	Homo sapiens	75-87
17037929-1	2006	We have proposed novel surface-imprinted beads for selective separation of cytochrome c (cyt c) by N-methacryloyl-(L)-histidine-copper(II) [MAH-Cu(II)] as a new metal-chelating monomer via metal coordination interactions and histidine template.	Histidine	118-127	cytochrome c, somatic	Homo sapiens	89-94
17037929-2	2006	We have combined molecular imprinting with the ability of histidine to chelate metal ions to create ligand exchange beads suitable for the binding of cyt c (surface histidine exposed protein).	Histidine	58-67	cytochrome c, somatic	Homo sapiens	150-155
17037929-2	2006	We have combined molecular imprinting with the ability of histidine to chelate metal ions to create ligand exchange beads suitable for the binding of cyt c (surface histidine exposed protein).	Histidine	165-174	cytochrome c, somatic	Homo sapiens	150-155
17037929-5	2006	L-Histidine imprinted metal-chelate beads can be used several times without considerable loss of cyt c adsorption capacity.	Histidine	0-11	cytochrome c, somatic	Homo sapiens	97-102
17037929-7	2006	Finally, we have used these histidine imprinted beads for cyt c and ribonuclease A (surface histidine exposed proteins) and enantiometric separation of D- and L-histidine by FPLC.	Histidine	28-37	cytochrome c, somatic	Homo sapiens	58-63
16908518-4	2006	We report that Smad10 is a mutant form of Smad4beta that harbors a missense mutation of a conserved arginine to histidine in the MH1 domain.	Histidine	112-121	SMAD family member 4, gene 2 L homeolog	Xenopus laevis	42-51
16807956-8	2006	For the d-His adduct, the residues involved in recognition of the activator were Trp5, His64, and Pro201, whereas two water molecules connected the zinc-bound water to the activator.	Histidine	10-13	transient receptor potential cation channel subfamily C member 5	Homo sapiens	81-85
16964241-2	2006	Aprataxin is a member of the histidine triad (HIT) family of nucleotide hydrolases and transferases, and inactivating mutations are largely confined to this HIT domain.	Histidine	29-38	aprataxin	Gallus gallus	0-9
16932909-7	2006	The orf1 had no nif homolog in DNA databases, and the highest level of identity (27% at amino acid level) was found with hutP, a positive regulatory gene of the histidine utilization (hut) operon in B. subtilis.	Histidine	161-170	hypothetical protein	Bacillus subtilis	4-8
16864587-6	2006	Instead of a glutamate, proposed to act as a general base, TAP1 contains an aspartate and a glutamine instead of the conserved histidine, which has been suggested to act as the linchpin.	Histidine	127-136	transporter 1, ATP binding cassette subfamily B member	Homo sapiens	59-63
16518858-5	2006	TAA90K-His bound to fibronectin, collagen IV, laminins-1, -5, and -10 and galectin-3 (Mac-2) but poorly to collagen I and galectin-1.	Histidine	7-10	fibronectin 1	Homo sapiens	20-31
16939204-5	2006	The selectivity of HNE in competing adduction reactions was evaluated by analysis of kinetics for HNE Michael adduction at six targeted HSA histidine residues.	Histidine	140-149	albumin	Homo sapiens	136-139
16766034-3	2006	The pyrrole-protons of the hemin of myoglobin in the absence of external ligand appeared as four resonances between -10 and -18 ppm, indicating a mainly low-spin ferric hemin, with a ligated distal histidine (His64).	Histidine	198-207	myoglobin	Equus caballus	36-45
16728398-0	2006	A conserved histidine in insulin is required for the foldability of human proinsulin: structure and function of an ALAB5 analog.	Histidine	12-21	insulin	Homo sapiens	25-32
16728398-0	2006	A conserved histidine in insulin is required for the foldability of human proinsulin: structure and function of an ALAB5 analog.	Histidine	12-21	insulin	Homo sapiens	74-84
16728398-7	2006	At the site of substitution, interchain nuclear Overhauser effects are observed between the methyl resonance of Ala(B5) and side chains in the A chain; these nuclear Overhauser effects resemble those characteristic of His(B5) in native insulin.	Histidine	218-221	insulin	Homo sapiens	236-243
16895604-2	2006	The two most commonly expressed fragile sites FRA3B and FRA16D host the histidine triad (FHIT) and WW domain containing oxidoreductase (WWOX) genes respectively.	Histidine	72-81	fragile site, aphidicolin type, common, fra(16)(q23.2)	Homo sapiens	56-62
16895604-2	2006	The two most commonly expressed fragile sites FRA3B and FRA16D host the histidine triad (FHIT) and WW domain containing oxidoreductase (WWOX) genes respectively.	Histidine	72-81	WW domain containing oxidoreductase	Homo sapiens	99-134
16895604-2	2006	The two most commonly expressed fragile sites FRA3B and FRA16D host the histidine triad (FHIT) and WW domain containing oxidoreductase (WWOX) genes respectively.	Histidine	72-81	WW domain containing oxidoreductase	Homo sapiens	136-140
16730978-4	2006	Excellent CA XIII activating properties were shown by D-amino acids (His, Phe, DOPA, and Trp), serotonin, and 4-(2-aminoethyl)-morpholine, whereas the corresponding L-amino acids, dopamine, histamine, and 1-(2-aminoethyl)-piperazine, were weaker activators.	Histidine	69-72	carbonic anhydrase 13	Homo sapiens	10-17
16866351-4	2006	Unlike the clan CA cysteine proteases, the catalytic histidine in caspase-3 plays a critical role during protonation and subsequent ring opening of the epoxide moiety and facilitates the nucleophilic attack by the active site cysteine.	Histidine	53-62	caspase 3	Homo sapiens	66-75
16866351-6	2006	A favorable network of hydrogen bonds involving the oxyanion hole, catalytic histidine, and the atoms in the prime site of the inhibitor enhance the binding affinity and specificity of the aza-peptide epoxide inhibitors toward caspase-3.	Histidine	77-86	caspase 3	Homo sapiens	227-236
16518850-5	2006	Recombinant cytochrome c oxidase solubilized in detergent is immobilized on a chemically modified gold surface via the affinity of its histidine (His)-tag to a nickel-chelating nitro-triacetic acid (NTA) surface.	Histidine	135-144	cytochrome c, somatic	Homo sapiens	12-24
16848423-7	2006	NMR titration experiments showed that the amide NH peak intensities of R5-L17 showed the most pronounced intensity reduction, and that the 1H signals for the side chain aromatic signals of the three histidines shift upfield (H6, H13, and H14).	Histidine	199-209	H1.3 linker histone, cluster member	Homo sapiens	229-232
16629640-0	2006	Evidence for allosteric regulation of pH-sensitive System A (SNAT2) and System N (SNAT5) amino acid transporter activity involving a conserved histidine residue.	Histidine	143-152	solute carrier family 38 member 5	Homo sapiens	82-87
16629640-4	2006	The histidine-modifying agent DEPC (diethyl pyrocarbonate) markedly reduces the pH-sensitivity of SNAT2 and SNAT5 transporters (representative isoforms of System A and N respectively, overexpressed in Xenopus oocytes) in a concentration-dependent manner but does not completely inactivate transport activity.	Histidine	4-13	solute carrier family 38 member 2 L homeolog	Xenopus laevis	98-103
16629640-4	2006	The histidine-modifying agent DEPC (diethyl pyrocarbonate) markedly reduces the pH-sensitivity of SNAT2 and SNAT5 transporters (representative isoforms of System A and N respectively, overexpressed in Xenopus oocytes) in a concentration-dependent manner but does not completely inactivate transport activity.	Histidine	4-13	solute carrier family 38 member 5 L homeolog	Xenopus laevis	108-113
16888169-1	2006	High-affinity-binding sites for the vasoactive intestinal peptide (VIP) analogs peptide histidine/isoleucine-amide (PHI)/carboxyterminal methionine instead of isoleucine (PHM) are expressed in numerous tissues in the body but the nature of their receptors remains to be elucidated.	Histidine	88-97	vasoactive intestinal peptide	Rattus norvegicus	67-70
16611635-2	2006	Pyroglutamyl peptidase II (PPII), a highly specific membrane-bound omegapeptidase, removes N-terminal pyroglutamyl from thyrotropin-releasing hormone (&lt;Glu-His-Pro-NH(2)), inactivating the peptide in the extracellular space.	Histidine	159-162	thyrotropin releasing hormone degrading enzyme	Homo sapiens	0-25
16910778-8	2006	L-Histidine, a (1)O(2) quencher, protected against the inactivation of cellular CuZnSOD, MnSOD, and catalase enzymes induced by photodynamically generated (1)O(2).	Histidine	0-11	superoxide dismutase 1, soluble	Mus musculus	80-87
16910778-8	2006	L-Histidine, a (1)O(2) quencher, protected against the inactivation of cellular CuZnSOD, MnSOD, and catalase enzymes induced by photodynamically generated (1)O(2).	Histidine	0-11	superoxide dismutase 2, mitochondrial	Mus musculus	89-94
16910778-8	2006	L-Histidine, a (1)O(2) quencher, protected against the inactivation of cellular CuZnSOD, MnSOD, and catalase enzymes induced by photodynamically generated (1)O(2).	Histidine	0-11	catalase	Mus musculus	100-108
16518850-5	2006	Recombinant cytochrome c oxidase solubilized in detergent is immobilized on a chemically modified gold surface via the affinity of its histidine (His)-tag to a nickel-chelating nitro-triacetic acid (NTA) surface.	Histidine	146-149	cytochrome c, somatic	Homo sapiens	12-24
16730205-3	2006	The B. ignitus SOD1 (BiSOD1) possesses the typical metal-binding ligands of six histidines and one aspartic acid common to SOD1s.	Histidine	80-90	superoxide dismutase 1	Apis mellifera	15-19
16484588-3	2006	To test the mechanism of its action, we constructed mutant forms of c-Mpl; murine c-Mpl(L490H) dis-played a response to NIP-004, whereas human c-Mpl(H499L) lost this response, indicating that histidine in the transmembrane domain of c-Mpl is essential for its activity.	Histidine	192-201	MPL proto-oncogene, thrombopoietin receptor	Homo sapiens	82-87
16636053-6	2006	Mutations of His/Cys residues in the HCCH motif impair zinc coordination, Cul5 binding, and APOBEC3G degradation.	Histidine	13-16	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	Homo sapiens	92-100
16786157-10	2006	Mapping of epitopes reactive for biotinylated his-tagged CRD1, CRD2 and mGalectin-4 performed on mouse cryosections showed that all three forms bind to alveolar macrophages, macrophages of red pulp of the spleen and proximal tubuli of the kidney and this binding was inhibited by 5 mM lactose.	Histidine	46-49	lectin, galactose binding, soluble 4	Mus musculus	72-83
16891471-6	2006	However, these cells did undergo apoptosis in response to another form of recombinant TRAIL, histidine-tagged TRAIL, suggesting differing contributions of DR4 and DR5 in the response to these two forms of TRAIL.	Histidine	93-102	TNF superfamily member 10	Homo sapiens	86-91
16891471-6	2006	However, these cells did undergo apoptosis in response to another form of recombinant TRAIL, histidine-tagged TRAIL, suggesting differing contributions of DR4 and DR5 in the response to these two forms of TRAIL.	Histidine	93-102	TNF superfamily member 10	Homo sapiens	110-115
16891471-6	2006	However, these cells did undergo apoptosis in response to another form of recombinant TRAIL, histidine-tagged TRAIL, suggesting differing contributions of DR4 and DR5 in the response to these two forms of TRAIL.	Histidine	93-102	TNF superfamily member 10	Homo sapiens	110-115
16484588-3	2006	To test the mechanism of its action, we constructed mutant forms of c-Mpl; murine c-Mpl(L490H) dis-played a response to NIP-004, whereas human c-Mpl(H499L) lost this response, indicating that histidine in the transmembrane domain of c-Mpl is essential for its activity.	Histidine	192-201	MPL proto-oncogene, thrombopoietin receptor	Homo sapiens	82-87
16678114-0	2006	RAP uses a histidine switch to regulate its interaction with LRP in the ER and Golgi.	Histidine	11-20	LDL receptor related protein 1	Homo sapiens	61-64
16603126-0	2006	ZmPUMP encodes a fully functional monocot plant uncoupling mitochondrial protein whose affinity to fatty acid is increased with the introduction of a His pair at the second matrix loop.	Histidine	150-153	Mitochondrial uncoupling protein 1	Zea mays	0-6
16603126-5	2006	ZmPUMP was also used to investigate the importance of a histidine pair present in the second matrix loop of mammalian UCP1 and absent in plant UCPs.	Histidine	56-65	Mitochondrial uncoupling protein 1	Zea mays	0-6
16513636-4	2006	A close look at the hydrogen-bonding possibilities around the distal His in cAOS suggested that the imidazole ring is rotated by 180 degrees relative to that of catalase because of the hydrogen bond between Thr-66 and the distal His-67.	Histidine	69-72	catalase	Homo sapiens	161-169
16513636-4	2006	A close look at the hydrogen-bonding possibilities around the distal His in cAOS suggested that the imidazole ring is rotated by 180 degrees relative to that of catalase because of the hydrogen bond between Thr-66 and the distal His-67.	Histidine	229-232	catalase	Homo sapiens	161-169
16634637-11	2006	CopH does not contain any cysteines or methionines but contains two histidines.	Histidine	68-78	CopH protein	Cupriavidus metallidurans CH34	0-4
16678114-5	2006	Structure-based mutagenesis studies in vitro and in cells confirm that the protonation of histidine residues as a consequence of the pH changes modulate the binding/release of RAP from LRP.	Histidine	90-99	LDL receptor related protein 1	Homo sapiens	185-188
16385614-4	2006	The Vmax of randomly immobilized his-tag ALP was 1.2 and the Vmax of site directed immobilized his-tag ALP was 1.5.	Histidine	33-36	alkaline phosphatase, placental	Homo sapiens	41-44
16651734-10	2006	Modification of carboxyl groups or hydroxyl groups had no significant influence on the pH-profile, whereas a chemical modification of histidine residue with diethylpyrocarbonate (DEPC) completely abolished the transport activity in CHO/hPEPT1 cells.	Histidine	134-143	solute carrier family 15 member 1	Homo sapiens	236-242
16651734-12	2006	This protection was observed only in the presence of the substrate of hPEPT1, indicating that the histidine residue is located at the substrate recognition site.	Histidine	98-107	solute carrier family 15 member 1	Homo sapiens	70-76
16385614-4	2006	The Vmax of randomly immobilized his-tag ALP was 1.2 and the Vmax of site directed immobilized his-tag ALP was 1.5.	Histidine	95-98	alkaline phosphatase, placental	Homo sapiens	103-106
16385614-5	2006	In other words, the activity of site directed immobilized his-tag ALP was about 1.3-folds increased.	Histidine	58-61	alkaline phosphatase, placental	Homo sapiens	66-69
16584196-6	2006	This pK(H) is low for alkaline conformers involving lysine-heme ligation but is consistent with the pK(a) of the highest of three ionizable groups which modulate formation of the histidine-heme alkaline conformer of a His 73 variant of iso-1-cytochrome c [Martinez, R. E., and Bowler, B. E. (2004) J.	Histidine	218-221	cytochrome c, somatic	Homo sapiens	242-254
16762846-2	2006	METHODS: Recombinant vectors pHis-TAT-p38 and pHis-TAT-p38(AF) were constructed, and two recombinant proteins, His-TAT-p38 and His-TAT-p38(AF), were expressed and purified in E. coli.	Histidine	47-50	mitogen-activated protein kinase 14	Homo sapiens	55-58
16531127-0	2006	Evaluation of IDA-PEVA hollow fiber membrane metal ion affinity chromatography for purification of a histidine-tagged human proinsulin.	Histidine	101-110	insulin	Homo sapiens	124-134
16762846-2	2006	METHODS: Recombinant vectors pHis-TAT-p38 and pHis-TAT-p38(AF) were constructed, and two recombinant proteins, His-TAT-p38 and His-TAT-p38(AF), were expressed and purified in E. coli.	Histidine	47-50	mitogen-activated protein kinase 14	Homo sapiens	55-58
16762846-2	2006	METHODS: Recombinant vectors pHis-TAT-p38 and pHis-TAT-p38(AF) were constructed, and two recombinant proteins, His-TAT-p38 and His-TAT-p38(AF), were expressed and purified in E. coli.	Histidine	47-50	mitogen-activated protein kinase 14	Homo sapiens	55-58
16762846-4	2006	The phosphorylation of ATF2 was detected to assay the effect of His-TAT-p38 on endogeneious p38 activity after the cells were stimulated by sorbitol.	Histidine	64-67	mitogen-activated protein kinase 14	Homo sapiens	72-75
16762846-4	2006	The phosphorylation of ATF2 was detected to assay the effect of His-TAT-p38 on endogeneious p38 activity after the cells were stimulated by sorbitol.	Histidine	64-67	mitogen-activated protein kinase 14	Homo sapiens	92-95
16762846-6	2006	The recombinant proteins of His-TAT-p38 and His-TAT-p38(AF) were isolated and purified by SDS-PAGE, and Western blotting suggested that His-TAT-p38 and its mutant with dual phosphorylation sites could enter the cells efficiently in a time- and concentration-dependent manner.	Histidine	28-31	mitogen-activated protein kinase 14	Homo sapiens	36-39
16584196-6	2006	This pK(H) is low for alkaline conformers involving lysine-heme ligation but is consistent with the pK(a) of the highest of three ionizable groups which modulate formation of the histidine-heme alkaline conformer of a His 73 variant of iso-1-cytochrome c [Martinez, R. E., and Bowler, B. E. (2004) J.	Histidine	179-188	cytochrome c, somatic	Homo sapiens	242-254
16517499-2	2006	Here, we examined Cu(2+)-binding property of paraoxonase 1 (PON1), and antioxidant actions of peptides, resembling His residue-containing sequences in PON1, against oxidations by Cu(2+), peroxyl radicals or HOCl.	Histidine	115-118	paraoxonase 1	Homo sapiens	151-155
16539846-10	2006	CONCLUSION: IL-28 and IL-29 cDNAs were successfully cloned and expressed in eukaryotic cells via transfection with pcDNA3.1/V5-His-TOPO-IL-28/IL-29.	Histidine	127-130	interferon lambda 3	Homo sapiens	12-17
16539846-10	2006	CONCLUSION: IL-28 and IL-29 cDNAs were successfully cloned and expressed in eukaryotic cells via transfection with pcDNA3.1/V5-His-TOPO-IL-28/IL-29.	Histidine	127-130	interferon lambda 3	Homo sapiens	136-141
16733894-4	2006	In eukaryotic expression system, the gene of c-Kit/Igl13 with eight histidine segments was cloned into pEAK12 and the recombinant plasmid was transfected into HEK293 ET cells.	Histidine	68-77	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	45-50
16581346-3	2006	As disruption of mitochondrial transmembrane potential (DeltaPsim), Leu-Glu-His-Asp ase (IETD ase) activity, and the appearance of hypodiploid DNA + cells were markedly suppressed in IFN-gamma-treated FLS in response to TRAIL, IFN-gamma-induced suppression was supposed to achieve at upstream of caspase-8.	Histidine	76-79	interferon gamma	Homo sapiens	183-192
16416505-4	2006	The carrier was designed to have the structure of (KHKHKHKHKK)6-FGF2 where lysine (K) residues would allow complexation with plasmid DNA, basic fibroblast growth factor (FGF2) to target cells over-expressing FGF2 receptors (FGFR), and histidine (H) residues to facilitate escape from the endosomal compartments.	Histidine	235-244	fibroblast growth factor 2	Homo sapiens	64-68
16516209-2	2006	Site-directed mutants of the redox-active Cys-Gly-His-Cys motif within an isolated ERp57 sub-domain have been studied.	Histidine	50-53	protein disulfide isomerase family A member 3	Homo sapiens	83-88
16251206-7	2006	We have found that the sequence specificities of Cr(III)-DNA and Cr(III)-histidine-DNA adducts in the p53 gene sequence are identical and that both types of adducts are preferentially formed at -NGG- sequences, including codons 245, 248 and 249, the mutational hotspots in human lung cancer.	Histidine	73-82	tumor protein p53	Homo sapiens	102-105
16407305-5	2006	We thus explored the role of all amino acids in the PON1 active site that are not directly ligated to the catalytic calcium and that possess an imidazolyl or carboxyl side chain (His(115), His(134), His(184), His(285), Asp(183), and Asp(269)).	Histidine	179-182	paraoxonase 1	Homo sapiens	52-56
16407305-7	2006	The results indicate that the lactonase activity of PON1 and PON3 and the esterase activity of PON1 are mediated by the His(115)-His(134) dyad.	Histidine	120-123	paraoxonase 1	Homo sapiens	52-56
16407305-7	2006	The results indicate that the lactonase activity of PON1 and PON3 and the esterase activity of PON1 are mediated by the His(115)-His(134) dyad.	Histidine	120-123	paraoxonase 1	Homo sapiens	95-99
16407305-7	2006	The results indicate that the lactonase activity of PON1 and PON3 and the esterase activity of PON1 are mediated by the His(115)-His(134) dyad.	Histidine	129-132	paraoxonase 1	Homo sapiens	52-56
16407305-7	2006	The results indicate that the lactonase activity of PON1 and PON3 and the esterase activity of PON1 are mediated by the His(115)-His(134) dyad.	Histidine	129-132	paraoxonase 1	Homo sapiens	95-99
16600130-7	2006	In the smoking group, there was 0.15 times (OR(adj) = 0.15, 95% CI: 0.03-0.68, P = 0.01) risks of BP for subjects carrying genotypes of hMYHc.335His/Gln + Gln/Gln compared with these carrying genotypes of hMYHc.335His/His.	Histidine	145-148	myosin heavy chain 6	Homo sapiens	136-141
16406008-3	2006	Here we report that GST-Ca(v)2.2 I-II loop, and to a lesser extent Ca(v)beta1b-His(6), are substrates for ERK1/2 phosphorylation.	Histidine	79-82	mitogen-activated protein kinase 3	Homo sapiens	106-112
16600130-7	2006	In the smoking group, there was 0.15 times (OR(adj) = 0.15, 95% CI: 0.03-0.68, P = 0.01) risks of BP for subjects carrying genotypes of hMYHc.335His/Gln + Gln/Gln compared with these carrying genotypes of hMYHc.335His/His.	Histidine	145-148	myosin heavy chain 6	Homo sapiens	205-210
16460041-0	2006	Autophosphorylation of Arabidopsis nucleoside diphosphate kinase 2 occurs only on its active histidine residue.	Histidine	93-102	nucleoside diphosphate kinase 2	Arabidopsis thaliana	35-66
16475821-2	2006	Analysis of recombinant His-tag UGTs from the 1A family for their ability to glucuronidate p-nitrophenol (pNP) and 4-methylumbelliferone (4-MU) revealed that UGT1A10 shows high activity toward phenols and phenol derivatives.	Histidine	24-27	UDP glucuronosyltransferase family 1 member A10	Homo sapiens	158-165
16460041-4	2006	Results revealed that NDPK2 is phosphorylated only on its active histidine residue His197 and the presence of serine/threonine phosphorylation is an experimental artifact due to the harsh condition applied in the treatment of the phosphorylated protein sample.	Histidine	65-74	nucleoside diphosphate kinase 2	Arabidopsis thaliana	22-27
16460041-7	2006	Further studies indicated that the low enzymatic activity and autophosphorylation level of NDPK2 mutant S199A are shown to be due to a damaged H-bonding with the active histidine residue His197 in the nucleotide-binding pocket.	Histidine	169-178	nucleoside diphosphate kinase 2	Arabidopsis thaliana	91-96
16266835-6	2006	Perturbations in specific 1H NMR resonances between residues 6 and 14, and analysis of various Abeta analogues in which each of the three His residues have been replaced by alanine, indicates that His6, His13 and His14 residues are implicated in Zn-Abeta binding.	Histidine	138-141	amyloid beta precursor protein	Homo sapiens	249-254
16186798-1	2006	The HINT1 protein, a member of the histidine triad (HIT) family, is highly conserved in diverse species and ubiquitously expressed in mammalian tissues.	Histidine	35-44	histidine triad nucleotide binding protein 1	Homo sapiens	4-9
16205735-13	2006	A third nonconservative change from histidine to glutamic acid was found in exon 8 of TSPEAR.	Histidine	36-45	thrombospondin type laminin G domain and EAR repeats	Mus musculus	86-92
16441657-5	2006	A subgroup of beta-ketoacyl-ACP synthases, including mitochondrial beta-ketoacyl-ACP synthase, bacterial plus plastid beta-ketoacyl-ACP synthases I and II, and a domain of human fatty acid synthase, have a Cys-His-His triad and also a completely conserved Lys in the active site.	Histidine	210-213	3-oxoacyl-ACP synthase, mitochondrial	Homo sapiens	14-40
16441657-5	2006	A subgroup of beta-ketoacyl-ACP synthases, including mitochondrial beta-ketoacyl-ACP synthase, bacterial plus plastid beta-ketoacyl-ACP synthases I and II, and a domain of human fatty acid synthase, have a Cys-His-His triad and also a completely conserved Lys in the active site.	Histidine	214-217	3-oxoacyl-ACP synthase, mitochondrial	Homo sapiens	14-40
16479084-3	2006	Direct sequencing of WT1 PCR products from genomic DNA identified WT1 mutations in exons 8 (366 Arg&gt;His) and 9 (396 Asp&gt;Tyr).	Histidine	103-106	WT1 transcription factor	Homo sapiens	21-24
16479084-3	2006	Direct sequencing of WT1 PCR products from genomic DNA identified WT1 mutations in exons 8 (366 Arg&gt;His) and 9 (396 Asp&gt;Tyr).	Histidine	103-106	WT1 transcription factor	Homo sapiens	66-69
16420561-5	2006	METHODS AND RESULTS: A recombinant VWF substrate containing the ADAMTS-13 cleavage site and a 6X Histidine tag was cleaved by ADAMTS-13 in a dose-dependent manner, generating approximately 7739 Da peptide containing a 6X Histidine tag.	Histidine	97-106	von Willebrand factor	Homo sapiens	35-38
16420561-5	2006	METHODS AND RESULTS: A recombinant VWF substrate containing the ADAMTS-13 cleavage site and a 6X Histidine tag was cleaved by ADAMTS-13 in a dose-dependent manner, generating approximately 7739 Da peptide containing a 6X Histidine tag.	Histidine	221-230	von Willebrand factor	Homo sapiens	35-38
16395674-2	2006	In knockout mice mismatch-repair (MMR) defects or inactivation of the fragile histidine triad (FHIT) gene are associated with MTS-like signs, including SGC.	Histidine	78-87	fragile histidine triad gene	Mus musculus	95-99
16407156-6	2006	In line with the predicted solute discrimination by size, replacement of both Phe-56 and His-180 (AQP1-F56A/H180A) enlarged the maximal diameter of the ar/R constriction 3-fold and enabled glycerol and urea to pass.	Histidine	89-92	aquaporin 1 (Colton blood group)	Homo sapiens	98-102
16430228-4	2006	EXAFS spectra of 1-Co(II)-CcrA suggest 5/6-coordinate Co(II) with two or more histidine ligands.	Histidine	78-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
16411775-0	2006	How gastric lipase, an interfacial enzyme with a Ser-His-Asp catalytic triad, acts optimally at acidic pH.	Histidine	53-56	lipase F, gastric type	Homo sapiens	4-18
16300908-2	2006	Here we describe a new plasmid for the eukaryotic expression of an anti-HER2/neu mini-antibody-barnase fusion protein (4D5 scFv-barnase-His(5)) with an NH(2)-terminal leader peptide.	Histidine	136-139	erb-b2 receptor tyrosine kinase 2	Homo sapiens	72-76
16300908-2	2006	Here we describe a new plasmid for the eukaryotic expression of an anti-HER2/neu mini-antibody-barnase fusion protein (4D5 scFv-barnase-His(5)) with an NH(2)-terminal leader peptide.	Histidine	136-139	erb-b2 receptor tyrosine kinase 2	Homo sapiens	77-80
16377684-6	2006	The purified histidine-tagged RmtC clearly showed methyltransferase activity against E. coli 16S rRNA in vitro.	Histidine	13-22	ribosomal RNA methyltransferase	Escherichia coli	30-34
16256128-6	2006	Analysis of mixed TNF trimers, prepared from tag-free TNF doped with various amounts of histidine-tagged TNF, revealed an increased retention of the trimeric protein on immobilized metal-ion affinity chromatography (IMAC) columns.	Histidine	88-97	tumor necrosis factor	Homo sapiens	18-21
16256128-7	2006	When 20% of histidine-tagged TNF was added, more than 50% of the protein was retained on the IMAC column.	Histidine	12-21	tumor necrosis factor	Homo sapiens	29-32
16256128-9	2006	Various histidine-tags were fused to the N-terminus of full-length TNF-alpha and to the truncated form (dN6) of TNF-alpha.	Histidine	8-17	tumor necrosis factor	Homo sapiens	67-76
16256128-9	2006	Various histidine-tags were fused to the N-terminus of full-length TNF-alpha and to the truncated form (dN6) of TNF-alpha.	Histidine	8-17	tumor necrosis factor	Homo sapiens	112-121
17106577-0	2006	Histidines 13 and 14 in the Abeta sequence are targets for inhibition of Alzheimer"s disease Abeta ion channel and cytotoxicity.	Histidine	0-10	amyloid beta precursor protein	Homo sapiens	28-33
16792821-3	2006	We also purified histidine-tagged SOD without an HIV-1 Tat and Tat-GFP as control proteins.	Histidine	17-26	superoxide dismutase 1	Homo sapiens	34-37
17106577-4	2006	We found that the ability of peptides to block Abeta channel activity could be lost by replacement of histidines 13 and 14 by alanine or lysine.	Histidine	102-112	amyloid beta precursor protein	Homo sapiens	47-52
16378185-2	2006	Two tumor suppressor genes, the fragile histidine triad (FHIT) gene and the WW domain-containing oxidoreductase (WWOX), map to the common fragile sites, FRA3B and FRA16D, respectively.	Histidine	40-49	WW domain containing oxidoreductase	Homo sapiens	76-111
16417235-8	2006	UVA irradiation of low phototype reconstructed epidermis and of U937 through synthetic pheomelanin induced a modification in the electrophoretic properties of native catalase, which was counteracted by histidine, a quencher of singlet oxygen.	Histidine	202-211	catalase	Homo sapiens	166-174
16378185-2	2006	Two tumor suppressor genes, the fragile histidine triad (FHIT) gene and the WW domain-containing oxidoreductase (WWOX), map to the common fragile sites, FRA3B and FRA16D, respectively.	Histidine	40-49	WW domain containing oxidoreductase	Homo sapiens	113-117
16572841-4	2006	PTEN was fused with 6 x His tag in pEP, and with Nus in pENP, which could be useful for a stable and soluble expression.	Histidine	24-27	phosphatase and tensin homolog	Mus musculus	0-4
16572841-7	2006	On the induction of 0.5mmol/L IPTG, 55kD and 118kD specific protein bands were observed, corresponding to His-PTEN and Nus-PTEN fusion proteins, respectively.	Histidine	106-109	phosphatase and tensin homolog	Mus musculus	110-114
16378185-2	2006	Two tumor suppressor genes, the fragile histidine triad (FHIT) gene and the WW domain-containing oxidoreductase (WWOX), map to the common fragile sites, FRA3B and FRA16D, respectively.	Histidine	40-49	fragile site, aphidicolin type, common, fra(16)(q23.2)	Homo sapiens	163-169
16572841-7	2006	On the induction of 0.5mmol/L IPTG, 55kD and 118kD specific protein bands were observed, corresponding to His-PTEN and Nus-PTEN fusion proteins, respectively.	Histidine	106-109	phosphatase and tensin homolog	Mus musculus	123-127
16450583-5	2006	The mutation of codon 840 CGT (arginine) to CAT (histidine) of AR gene led to the infertility in the patients.	Histidine	49-58	catalase	Homo sapiens	44-47
16572841-10	2006	Higher expression levels of recombinant PTEN were obtained in BL (His-PTEN: 10.3%; NusA-PTEN: 18.7%), whereas the higher percentages of soluble recombinant proteins were observed in RG (His-PTEN: 4.7%; Nus-PTEN: 6.6%).	Histidine	66-69	phosphatase and tensin homolog	Mus musculus	40-44
16572841-10	2006	Higher expression levels of recombinant PTEN were obtained in BL (His-PTEN: 10.3%; NusA-PTEN: 18.7%), whereas the higher percentages of soluble recombinant proteins were observed in RG (His-PTEN: 4.7%; Nus-PTEN: 6.6%).	Histidine	66-69	phosphatase and tensin homolog	Mus musculus	70-74
16572841-10	2006	Higher expression levels of recombinant PTEN were obtained in BL (His-PTEN: 10.3%; NusA-PTEN: 18.7%), whereas the higher percentages of soluble recombinant proteins were observed in RG (His-PTEN: 4.7%; Nus-PTEN: 6.6%).	Histidine	66-69	phosphatase and tensin homolog	Mus musculus	70-74
16572841-10	2006	Higher expression levels of recombinant PTEN were obtained in BL (His-PTEN: 10.3%; NusA-PTEN: 18.7%), whereas the higher percentages of soluble recombinant proteins were observed in RG (His-PTEN: 4.7%; Nus-PTEN: 6.6%).	Histidine	66-69	phosphatase and tensin homolog	Mus musculus	70-74
16572841-10	2006	Higher expression levels of recombinant PTEN were obtained in BL (His-PTEN: 10.3%; NusA-PTEN: 18.7%), whereas the higher percentages of soluble recombinant proteins were observed in RG (His-PTEN: 4.7%; Nus-PTEN: 6.6%).	Histidine	66-69	phosphatase and tensin homolog	Mus musculus	70-74
16450583-5	2006	The mutation of codon 840 CGT (arginine) to CAT (histidine) of AR gene led to the infertility in the patients.	Histidine	49-58	androgen receptor	Homo sapiens	63-65
16450583-7	2006	The clinical phenotype of theirs presented more deleteriously than and different from the one reported before, though they had the same mutation of codon 840 CGT (arginine) to CAT (histidine) of AR gene, which was very different from the mutation of 840 CGT (arginine) to TGT (cysteine) at the same codon.	Histidine	181-190	catalase	Homo sapiens	176-179
16450583-7	2006	The clinical phenotype of theirs presented more deleteriously than and different from the one reported before, though they had the same mutation of codon 840 CGT (arginine) to CAT (histidine) of AR gene, which was very different from the mutation of 840 CGT (arginine) to TGT (cysteine) at the same codon.	Histidine	181-190	androgen receptor	Homo sapiens	195-197
16450583-7	2006	The clinical phenotype of theirs presented more deleteriously than and different from the one reported before, though they had the same mutation of codon 840 CGT (arginine) to CAT (histidine) of AR gene, which was very different from the mutation of 840 CGT (arginine) to TGT (cysteine) at the same codon.	Histidine	181-190	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	272-275
16406803-6	2005	The PGIS cDNA is modified by replacing the hydrophobic amino-terminal sequence with the more hydrophilic amino-terminal sequence from P450 2C5 and by adding a four-histidine tag at the carboxyl terminus.	Histidine	164-173	prostaglandin I2 synthase	Homo sapiens	4-8
16223732-4	2005	Here we show that the glucose metabolites pyruvate and oxaloacetate inactivate HIF-1alpha decay in a manner selectively reversible by ascorbate, cysteine, histidine, and ferrous iron but not by 2-oxoglutarate or oxygen.	Histidine	155-164	hypoxia inducible factor 1 subunit alpha	Homo sapiens	79-89
16363796-10	2005	A comparison of the NIPs and tonoplast-intrinsic proteins (TIP) shows that the H2 residue can predict the transport profile for water and glycerol with histidine found in TIP-like aquaporins, tryptophan found in aquaglyceroporins (NIP I), and alanine found in water-impermeable glyceroporins (AtNIP6;1).	Histidine	152-161	NOD26-like intrinsic protein 6;1	Arabidopsis thaliana	293-301
16271394-3	2005	The computed results based on a binuclear Cu complex predict that oxidation of cholesterol (yielding 4-cholesten-3-one as a specific product) proceeds at a slow rate when catalyzed by a Abeta/Cu(II) His- Cu(II)/Abeta) aggregate.	Histidine	199-202	amyloid beta precursor protein	Homo sapiens	186-191
16059916-2	2005	Human cancer cells HeLa (cervix cancer, p53(+/+)), Saos-2 and Saos-2-His-273 (osteosarcoma, p53(-/-) and p53 His-273 mutant, respectively), H1299tTA and H1299tTA-His175 (lung carcinoma, p53(-/-) and p53 His-175 mutant), and normal human fibroblasts VH-10 (p53(+/+)) were used.	Histidine	69-72	tumor protein p53	Homo sapiens	92-95
16059916-2	2005	Human cancer cells HeLa (cervix cancer, p53(+/+)), Saos-2 and Saos-2-His-273 (osteosarcoma, p53(-/-) and p53 His-273 mutant, respectively), H1299tTA and H1299tTA-His175 (lung carcinoma, p53(-/-) and p53 His-175 mutant), and normal human fibroblasts VH-10 (p53(+/+)) were used.	Histidine	69-72	tumor protein p53	Homo sapiens	92-95
16059916-2	2005	Human cancer cells HeLa (cervix cancer, p53(+/+)), Saos-2 and Saos-2-His-273 (osteosarcoma, p53(-/-) and p53 His-273 mutant, respectively), H1299tTA and H1299tTA-His175 (lung carcinoma, p53(-/-) and p53 His-175 mutant), and normal human fibroblasts VH-10 (p53(+/+)) were used.	Histidine	69-72	tumor protein p53	Homo sapiens	92-95
16059916-2	2005	Human cancer cells HeLa (cervix cancer, p53(+/+)), Saos-2 and Saos-2-His-273 (osteosarcoma, p53(-/-) and p53 His-273 mutant, respectively), H1299tTA and H1299tTA-His175 (lung carcinoma, p53(-/-) and p53 His-175 mutant), and normal human fibroblasts VH-10 (p53(+/+)) were used.	Histidine	69-72	tumor protein p53	Homo sapiens	92-95
16059916-2	2005	Human cancer cells HeLa (cervix cancer, p53(+/+)), Saos-2 and Saos-2-His-273 (osteosarcoma, p53(-/-) and p53 His-273 mutant, respectively), H1299tTA and H1299tTA-His175 (lung carcinoma, p53(-/-) and p53 His-175 mutant), and normal human fibroblasts VH-10 (p53(+/+)) were used.	Histidine	69-72	tumor protein p53	Homo sapiens	92-95
16327157-4	2005	Human CYP2D6 containing histidine tag was expressed in Escherichia coli.	Histidine	24-33	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	6-12
16267663-0	2005	Ab initio model studies of copper binding to peptides containing a His-His sequence: relevance to the beta-amyloid peptide of Alzheimer"s disease.	Histidine	67-70	amyloid beta precursor protein	Homo sapiens	102-122
16052286-3	2005	To identify the cleavage site of SaV ORF1, putative p70 (Pro-Pol) and p14-p70 (VPg-Pro-Pol) were expressed as N-terminal GST and C-terminal 6 x His-tag fusion proteins in Escherichia coli, and the expressed products were analyzed by SDS-PAGE and Western blotting.	Histidine	144-147	hypothetical protein	Escherichia coli	37-41
16052286-3	2005	To identify the cleavage site of SaV ORF1, putative p70 (Pro-Pol) and p14-p70 (VPg-Pro-Pol) were expressed as N-terminal GST and C-terminal 6 x His-tag fusion proteins in Escherichia coli, and the expressed products were analyzed by SDS-PAGE and Western blotting.	Histidine	144-147	ubiquitin associated and SH3 domain containing B	Homo sapiens	52-55
16252006-6	2005	Thus, our findings indicate that WINAC associates with chromatin through a physical interaction between the WSTF bromodomain and acetylated his tones, which appears to be indispensable for VDR/promoter association for ligand-induced transrepression of 1alpha(OH)ase gene expression.	Histidine	140-143	bromodomain adjacent to zinc finger domain 1B	Homo sapiens	108-112
16252006-6	2005	Thus, our findings indicate that WINAC associates with chromatin through a physical interaction between the WSTF bromodomain and acetylated his tones, which appears to be indispensable for VDR/promoter association for ligand-induced transrepression of 1alpha(OH)ase gene expression.	Histidine	140-143	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	252-265
16255580-1	2005	A recombinant single-chain fragment variable (scFv) antibody (designated A10B) was engineered to contain two histidines within the linker peptide used to join the scFv heavy and light chains.	Histidine	109-119	immunglobulin heavy chain variable region	Homo sapiens	46-50
16274242-1	2005	The alkaline transition kinetics of a Lys 73--&gt;His (H73) variant of iso-1-cytochrome c are triggered by three ionizable groups [Martinez, R. E., and Bowler, B. E. (2004) J.	Histidine	50-53	cytochrome c, somatic	Homo sapiens	77-89
16216268-1	2005	The human cytokine interleukin-1beta (IL-1beta) interacts with the interleukin type I receptor using two large docking surfaces designated A and B. Crystallographic studies reveal that a single histidine residue (His30) in IL-1beta makes critical electrostatic interactions at the receptor/ligand interface.	Histidine	194-203	interleukin 1 beta	Homo sapiens	19-36
16216268-1	2005	The human cytokine interleukin-1beta (IL-1beta) interacts with the interleukin type I receptor using two large docking surfaces designated A and B. Crystallographic studies reveal that a single histidine residue (His30) in IL-1beta makes critical electrostatic interactions at the receptor/ligand interface.	Histidine	194-203	interleukin 1 beta	Homo sapiens	38-46
16216268-1	2005	The human cytokine interleukin-1beta (IL-1beta) interacts with the interleukin type I receptor using two large docking surfaces designated A and B. Crystallographic studies reveal that a single histidine residue (His30) in IL-1beta makes critical electrostatic interactions at the receptor/ligand interface.	Histidine	194-203	interleukin 1 beta	Homo sapiens	223-231
16245941-0	2005	Ionization of His 55 at the dimer interface of dynein light-chain LC8 is coupled to dimer dissociation.	Histidine	14-17	dynein light chain LC8-type 1	Homo sapiens	66-69
16033330-4	2005	We demonstrate here that a 1:1 stoichiometry for the binding of the common ACE inhibitors, captopril and lisinopril, to human s-ACE is enough to abolish enzymatic activity towards FA {N-[3-(2-furyl)acryloyl]}-Phe-GlyGly, Cbz (benzyloxycarbonyl)-Phe-His-Leu or Hip (N-benzoylglycyl)-His-Leu.	Histidine	249-252	angiotensin I converting enzyme	Homo sapiens	75-78
16033330-4	2005	We demonstrate here that a 1:1 stoichiometry for the binding of the common ACE inhibitors, captopril and lisinopril, to human s-ACE is enough to abolish enzymatic activity towards FA {N-[3-(2-furyl)acryloyl]}-Phe-GlyGly, Cbz (benzyloxycarbonyl)-Phe-His-Leu or Hip (N-benzoylglycyl)-His-Leu.	Histidine	249-252	angiotensin I converting enzyme	Homo sapiens	128-131
16033330-6	2005	Kinetic analysis of the simultaneous hydrolysis of two substrates, Hip-His-Leu (S1) and Cbz-Phe-His-Leu (S2), with a common product (His-Leu) by s-ACE at different values for the ratio of the initial concentrations of these substrates (i.e. sigma=[S2]0/[S1]0) demonstrated competition of these substrates for binding to the s-ACE molecule, i.e. binding of a substrate at one active site makes the other site unavailable for either the same or a different substrate.	Histidine	71-74	angiotensin I converting enzyme	Homo sapiens	147-150
16245941-7	2005	Titration curves for His 55 and the two other histidines, His 72 and 68, were determined by (13)C-(1)H NMR for H55K and for WT-LC8 in the monomeric and dimeric states.	Histidine	46-56	dynein light chain LC8-type 1	Homo sapiens	127-130
16245941-7	2005	Titration curves for His 55 and the two other histidines, His 72 and 68, were determined by (13)C-(1)H NMR for H55K and for WT-LC8 in the monomeric and dimeric states.	Histidine	21-24	dynein light chain LC8-type 1	Homo sapiens	127-130
16184188-2	2005	However, the corresponding binding site of GABAA receptors containing either an alpha4 or alpha6 subunit do not bind the classical BZs and are therefore diazepam-insensitive (DIS) receptors; a difference attributable to a single amino acid (histidine in alpha1, alpha2, alpha3 and alpha5 subunits and arginine in alpha4 and alpha6).	Histidine	241-250	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	262-287
16287242-4	2005	The TNF mutants were modified at the N-terminus by PCR cloning by introducing a His-Tag for purification and a free cysteine group for reaction with the particle-attached maleimide group.	Histidine	80-83	tumor necrosis factor	Homo sapiens	4-7
16225839-3	2005	IAsys biosensor studies show that binding of His-tagged B7.1 (B7.1-6H) to NTA(3)-DTDA-containing membranes, exhibit a faster on-rate and a slower off-rate, compared to membranes containing NTA-DTDA.	Histidine	45-48	CD80 antigen	Mus musculus	56-60
16054143-6	2005	This assay makes use of soluble His-tagged Bcl-XL and fluorescein tagged BH3.	Histidine	32-35	BCL2 like 1	Homo sapiens	43-49
16220978-1	2005	Two 1,3,5-trisubstituted aromatic scaffolds intended to serve as gamma-turn mimetics have been synthesized and incorporated in five pseudopeptide analogues of angiotensin II (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe), replacing Val-Tyr-Ile, Val-Tyr, or Tyr-Ile.	Histidine	195-198	angiotensinogen	Homo sapiens	159-173
16105738-1	2005	Extensive structure-activity relationship studies utilizing a beta-MSH-derived cyclic nonapeptide, Ac-Tyr-Arg-[Cys-Glu-His-D-Phe-Arg-Trp-Cys]-NH(2) (3), led to identification of a series of novel MC-4R selective disulfide-constrained hexapeptide analogs including Ac-[hCys-His-D-Phe-Arg-Trp-Cys]-NH(2) (12).	Histidine	119-122	msh homeobox 2	Homo sapiens	67-70
16225839-3	2005	IAsys biosensor studies show that binding of His-tagged B7.1 (B7.1-6H) to NTA(3)-DTDA-containing membranes, exhibit a faster on-rate and a slower off-rate, compared to membranes containing NTA-DTDA.	Histidine	45-48	CD80 antigen	Mus musculus	62-69
16201751-0	2005	Structural characterization of the proximal and distal histidine environment of cytoglobin and neuroglobin.	Histidine	55-64	cytoglobin	Homo sapiens	80-90
16129418-5	2005	We further conclude that residue 161, an Asn in QR2 and a His in QR1, is critical in differentiating the substrate specificities of these two enzymes.	Histidine	58-61	NAD(P)H quinone dehydrogenase 1	Homo sapiens	65-68
16201751-1	2005	Cytoglobin (Cgb) and neuroglobin (Ngb) are the first examples of hexacoordinated globins from humans and other vertebrates in which a histidine (His) residue at the sixth position of the heme iron is an endogenous ligand in both the ferric and ferrous forms.	Histidine	134-143	cytoglobin	Homo sapiens	0-10
16201751-1	2005	Cytoglobin (Cgb) and neuroglobin (Ngb) are the first examples of hexacoordinated globins from humans and other vertebrates in which a histidine (His) residue at the sixth position of the heme iron is an endogenous ligand in both the ferric and ferrous forms.	Histidine	134-143	cytoglobin	Homo sapiens	12-15
16201751-1	2005	Cytoglobin (Cgb) and neuroglobin (Ngb) are the first examples of hexacoordinated globins from humans and other vertebrates in which a histidine (His) residue at the sixth position of the heme iron is an endogenous ligand in both the ferric and ferrous forms.	Histidine	145-148	cytoglobin	Homo sapiens	0-10
16201751-1	2005	Cytoglobin (Cgb) and neuroglobin (Ngb) are the first examples of hexacoordinated globins from humans and other vertebrates in which a histidine (His) residue at the sixth position of the heme iron is an endogenous ligand in both the ferric and ferrous forms.	Histidine	145-148	cytoglobin	Homo sapiens	12-15
16185063-5	2005	By means of potentiometric and spectroscopic techniques (nuclear magnetic resonance, circular dichroism, UV-vis, and electronic paramagnetic resonance), it was shown that Cu(II) ions coordinate to the chicken PrP hexapeptide domain in physiological pH via imidazole nitrogen donors of His residue(s).	Histidine	285-288	prion protein	Homo sapiens	209-212
16140256-8	2005	Considering that those residues could be protected by caspase-3-specific inhibitor from the inactivation, the modifiers are histidine- and cysteine-specific, respectively, and the involvement of these residues in the characteristic catalytic dyad of caspases, the results indicate that the pKa values of the catalytic histidine and cysteine residues are changed during the activation process.	Histidine	124-133	caspase 3	Homo sapiens	54-63
16139234-6	2005	The increased coupling strength provided via the bivalent anchoring significantly reduced scFv displacement in complex solutions containing large amounts of histidine-containing proteins, verified via cholera toxin detection in serum.	Histidine	157-166	immunglobulin heavy chain variable region	Homo sapiens	90-94
16140256-8	2005	Considering that those residues could be protected by caspase-3-specific inhibitor from the inactivation, the modifiers are histidine- and cysteine-specific, respectively, and the involvement of these residues in the characteristic catalytic dyad of caspases, the results indicate that the pKa values of the catalytic histidine and cysteine residues are changed during the activation process.	Histidine	318-327	caspase 3	Homo sapiens	54-63
15975984-2	2005	To identify specific Cd(2+)-binding sites on the hERG channel, we mutated potential Cd(2+)-coordination residues located in the transmembrane domains or extracellular loops linking these domains, including five Cys, three His, nine Asp and eight Glu residues.	Histidine	222-225	ETS transcription factor ERG	Homo sapiens	49-53
16133205-4	2005	Comparison of the reduction thermodynamics for the cyanide adducts of cytochrome c and plant peroxidases with those for microperoxidase-11 and myoglobin, respectively, yielded an estimate of the consequences of protein encapsulation and of the anionic character of the proximal histidine on the reduction potential of the heme-cyanide group.	Histidine	278-287	cytochrome c, somatic	Homo sapiens	70-82
16186255-12	2005	Proteins that contain an Asp-His-His-Cys (DHHC)-cysteine rich domain (CRD) are emerging as a family of protein acyltransferases, and are therefore candidates for mediators of Vac8p palmitoylation.	Histidine	29-32	protein anchor VAC8	Saccharomyces cerevisiae S288C	175-180
16148611-4	2005	RESULTS: Two peaks (at 136 and 69 kDa) with ACE activity upon ZPhe-His-Leu were separated by gel filtration from homogenate tissues of Wistar rats, in contrast with the tissue from hypertensive rats, which showed ACE forms of 96 and 69 kDa.	Histidine	67-70	angiotensin I converting enzyme	Rattus norvegicus	44-47
16083441-6	2005	C-terminal histidine (His)-tagged CB1 gave a Bmax higher than most other systems previously reported in the literature, and was selected for subsequent metal affinity chromatography purification and mass spectroscopic (MS) analysis.	Histidine	11-20	cannabinoid receptor 1	Homo sapiens	34-37
16083441-6	2005	C-terminal histidine (His)-tagged CB1 gave a Bmax higher than most other systems previously reported in the literature, and was selected for subsequent metal affinity chromatography purification and mass spectroscopic (MS) analysis.	Histidine	22-25	cannabinoid receptor 1	Homo sapiens	34-37
16083441-7	2005	Moreover, cells expressing C-terminal His-tagged CB1 were shown to inhibit forskolin-stimulated cyclic adenosine 3",5"-monophosphate (cAMP) production in a concentration-dependent manner in the presence of CP-55,940, confirming the expressed receptor"s functional characteristics.	Histidine	38-41	cannabinoid receptor 1	Homo sapiens	49-52
16107255-0	2005	Histidine inhibits oxidative stress- and TNF-alpha-induced interleukin-8 secretion in intestinal epithelial cells.	Histidine	0-9	tumor necrosis factor	Homo sapiens	41-50
16107255-0	2005	Histidine inhibits oxidative stress- and TNF-alpha-induced interleukin-8 secretion in intestinal epithelial cells.	Histidine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	59-72
16107255-2	2005	We found that histidine, one of the conditionally essential amino acids, significantly inhibited both hydrogen peroxide- and TNF-alpha-induced IL-8 secretion and mRNA expression in Caco-2 cells and HT-29 cells.	Histidine	14-23	tumor necrosis factor	Homo sapiens	125-134
16107255-2	2005	We found that histidine, one of the conditionally essential amino acids, significantly inhibited both hydrogen peroxide- and TNF-alpha-induced IL-8 secretion and mRNA expression in Caco-2 cells and HT-29 cells.	Histidine	14-23	C-X-C motif chemokine ligand 8	Homo sapiens	143-147
16107255-4	2005	TNF-alpha increased the transcriptional activity of the IL-8 promoter which was significantly inhibited by treating Caco-2 cells with histidine.	Histidine	134-143	tumor necrosis factor	Homo sapiens	0-9
16107255-4	2005	TNF-alpha increased the transcriptional activity of the IL-8 promoter which was significantly inhibited by treating Caco-2 cells with histidine.	Histidine	134-143	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
16107255-5	2005	Histidine also abolished the NF-kappaB-dependent activation of the IL-8 promoter induced by TNF-alpha.	Histidine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
16107255-5	2005	Histidine also abolished the NF-kappaB-dependent activation of the IL-8 promoter induced by TNF-alpha.	Histidine	0-9	tumor necrosis factor	Homo sapiens	92-101
16107255-6	2005	These results indicate that histidine inhibited the hydrogen peroxide- and TNF-alpha-induced IL-8 secretion at the transcriptional level in intestinal epithelial cells, suggesting that histidine has the potential to attenuate intestinal inflammation.	Histidine	28-37	tumor necrosis factor	Homo sapiens	75-84
16107255-6	2005	These results indicate that histidine inhibited the hydrogen peroxide- and TNF-alpha-induced IL-8 secretion at the transcriptional level in intestinal epithelial cells, suggesting that histidine has the potential to attenuate intestinal inflammation.	Histidine	28-37	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
16107255-6	2005	These results indicate that histidine inhibited the hydrogen peroxide- and TNF-alpha-induced IL-8 secretion at the transcriptional level in intestinal epithelial cells, suggesting that histidine has the potential to attenuate intestinal inflammation.	Histidine	185-194	tumor necrosis factor	Homo sapiens	75-84
16107255-6	2005	These results indicate that histidine inhibited the hydrogen peroxide- and TNF-alpha-induced IL-8 secretion at the transcriptional level in intestinal epithelial cells, suggesting that histidine has the potential to attenuate intestinal inflammation.	Histidine	185-194	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
15899884-8	2005	Consistently, the transport of the substrate l-histidine was increased with short, but not long, treatment by insulin in both H2.35- and SNAT3-transfected COS-7 cells.	Histidine	45-56	insulin	Homo sapiens	110-117
15980068-2	2005	We show here that mutation of three highly conserved residues in NS2 (His(952), Glu(972), and Cys(993)) abrogates NS2/3 protease activity and that introduction of any of these mutations into subgenomic NS2-5B replicons results in complete inactivation of NS2/3 processing and RNA replication in both stable and transient replication assays.	Histidine	70-73	NS2	Homo sapiens	65-68
15980068-2	2005	We show here that mutation of three highly conserved residues in NS2 (His(952), Glu(972), and Cys(993)) abrogates NS2/3 protease activity and that introduction of any of these mutations into subgenomic NS2-5B replicons results in complete inactivation of NS2/3 processing and RNA replication in both stable and transient replication assays.	Histidine	70-73	NS2	Homo sapiens	114-119
15980068-2	2005	We show here that mutation of three highly conserved residues in NS2 (His(952), Glu(972), and Cys(993)) abrogates NS2/3 protease activity and that introduction of any of these mutations into subgenomic NS2-5B replicons results in complete inactivation of NS2/3 processing and RNA replication in both stable and transient replication assays.	Histidine	70-73	NS2	Homo sapiens	114-117
15980068-2	2005	We show here that mutation of three highly conserved residues in NS2 (His(952), Glu(972), and Cys(993)) abrogates NS2/3 protease activity and that introduction of any of these mutations into subgenomic NS2-5B replicons results in complete inactivation of NS2/3 processing and RNA replication in both stable and transient replication assays.	Histidine	70-73	NS2	Homo sapiens	114-117
16055450-1	2005	Six Cys(2)His(2) zinc fingers (F1-6) comprise the DNA binding domain of metal-responsive element binding transcription factor-1 (MTF-1).	Histidine	10-13	coagulation factor II, thrombin	Homo sapiens	31-35
15899884-8	2005	Consistently, the transport of the substrate l-histidine was increased with short, but not long, treatment by insulin in both H2.35- and SNAT3-transfected COS-7 cells.	Histidine	45-56	solute carrier family 38 member 3	Homo sapiens	137-142
15964569-1	2005	The strong pH dependence of A beta oligomerization could arise from favorable intermolecular charge-charge interactions between His and carboxylate groups, or, alternatively, by mutual electrostatic repulsion of peptide molecules.	Histidine	128-131	amyloid beta precursor protein	Homo sapiens	28-34
16014379-2	2005	In this study, Hint1/PKCI, a member of the evolutionary conserved family of histidine triad proteins, was characterised as a new interaction partner of Pontin and Reptin.	Histidine	76-85	histidine triad nucleotide binding protein 1	Homo sapiens	15-20
16014379-2	2005	In this study, Hint1/PKCI, a member of the evolutionary conserved family of histidine triad proteins, was characterised as a new interaction partner of Pontin and Reptin.	Histidine	76-85	RuvB like AAA ATPase 1	Homo sapiens	152-158
16014379-2	2005	In this study, Hint1/PKCI, a member of the evolutionary conserved family of histidine triad proteins, was characterised as a new interaction partner of Pontin and Reptin.	Histidine	76-85	RuvB like AAA ATPase 2	Homo sapiens	163-169
15741241-1	2005	Histidase (Hal), the amino acid-degrading enzyme of histidine, is regulated by the protein content of the diet and by hormones such as glucocorticoids and glucagon.	Histidine	52-61	histidine ammonia lyase	Rattus norvegicus	0-9
15741241-1	2005	Histidase (Hal), the amino acid-degrading enzyme of histidine, is regulated by the protein content of the diet and by hormones such as glucocorticoids and glucagon.	Histidine	52-61	histidine ammonia lyase	Rattus norvegicus	11-14
16004422-6	2005	Oriented coupling of the Fab fragments on chelate-epoxy cellulose via a C-terminal histidine tag, however, increased the adsorption capacity to 178.3 +/- 8.6 pg TNF/mg adsorbent wet weight.	Histidine	83-92	tumor necrosis factor	Homo sapiens	161-164
15965534-3	2005	Previous studies of the chimeric proteins, which incorporate the ligand-binding domain of the human ER, identified Cys 381, Cys 447, Glu 523, His 524 and Asp 538 as possible sites of interactions with cadmium.	Histidine	142-145	estrogen receptor 1	Homo sapiens	100-102
16091881-1	2005	Histidine-tagged N (rNH) and E (rEH) proteins of Severe Acute Respiratory Syndrome (SARS)-coronovirus were expressed in the baculovirus/insect cell system and purified by immobilized metal affinity chromatography.	Histidine	0-9	carboxylesterase 1C	Rattus norvegicus	32-35
15942685-7	2005	These findings, therefore, indicate that histidine residues at both P2 and P3" positions probably associate with the renin catalytic reaction for angiotensin I generation.	Histidine	41-50	renin	Homo sapiens	117-122
15942685-7	2005	These findings, therefore, indicate that histidine residues at both P2 and P3" positions probably associate with the renin catalytic reaction for angiotensin I generation.	Histidine	41-50	angiotensinogen	Homo sapiens	146-159
16335786-6	2005	The minimal RNF10 binding region of MEOX2 was determined to be a central region between the histidine/glutamine rich domain and the homeodomain (amino acids 101-185).	Histidine	92-101	ring finger protein 10	Homo sapiens	12-17
16335786-6	2005	The minimal RNF10 binding region of MEOX2 was determined to be a central region between the histidine/glutamine rich domain and the homeodomain (amino acids 101-185).	Histidine	92-101	mesenchyme homeobox 2	Homo sapiens	36-41
15840587-4	2005	Biochemical analysis showed that bacterial His-tagged p12 could be converted into a dimeric p25 in a reducing agent-dependent manner, and mutating the only cysteine residue of p12 (Cys(105) --&gt; Ala(105)) abolished the dimerization.	Histidine	43-46	DNA polymerase epsilon 4, accessory subunit	Homo sapiens	54-57
15840587-4	2005	Biochemical analysis showed that bacterial His-tagged p12 could be converted into a dimeric p25 in a reducing agent-dependent manner, and mutating the only cysteine residue of p12 (Cys(105) --&gt; Ala(105)) abolished the dimerization.	Histidine	43-46	DNA polymerase epsilon 4, accessory subunit	Homo sapiens	176-179
15890278-3	2005	Using data from c-AMP assays in combination with structural analysis of melanocortin receptor/ligand models, we conclude that a lysine residue at the C-terminus of the His-Phe-Arg-Trp core sequence of melanocortin hormone is an important determinant for receptor selectivity in the both cyclic and linear MSH analogues.	Histidine	168-171	msh homeobox 2	Homo sapiens	305-308
15817634-5	2005	Critical glutamate, aspartate, lysine, arginine and histidine residues in ILs/ELs and TMs were detected that were essential for kNBC1-mediated Na(+)-dependent base transport.	Histidine	52-61	solute carrier family 4 member 4	Homo sapiens	128-133
15924420-1	2005	Each homologous lobe of human serum transferrin (hTF) has one Fe(3+) ion bound by an aspartic acid, a histidine, two tyrosine residues, and two oxygens from the synergistic anion, carbonate.	Histidine	102-111	transferrin	Homo sapiens	36-47
15790557-3	2005	Disease-associated mutations in Aprataxin target a histidine triad domain that is similar to Hint, a universally conserved AMP-lysine hydrolase, or truncate the protein NH2-terminal to a zinc finger.	Histidine	51-60	histidine triad nucleotide binding protein 1	Homo sapiens	93-97
15769590-2	2005	A histidine-containing phosphotransfer protein, YPD1, represents a bifurcation point between the SLN1-YPD1-SSK1 pathway responsible for osmotic stress responses and the SLN1-YPD1-SKN7 pathway involved in cell wall biosynthesis and cell cycle control.	Histidine	2-11	mitogen-activated protein kinase kinase kinase SSK1	Saccharomyces cerevisiae S288C	107-111
15661971-9	2005	OD rats showed increases in ACE activity in heart, kidney, and lung (1.13+/-0.24, 3.04+/-0.86, 40.8+/-8.9 vs. 0.73+/-0.19, 1.7+/-0.45, 28.1+/-6 nmol His-Leu.min-1 mg protein-1, OD vs. OC).	Histidine	149-152	angiotensin I converting enzyme	Rattus norvegicus	28-31
15806598-0	2005	Association of the apolipoprotein A-IV: 360 Gln/His polymorphism with cerebrovascular disease, obesity, and depression in a Brazilian elderly population.	Histidine	48-51	apolipoprotein A4	Homo sapiens	19-38
15755742-5	2005	Specifically, we find that XendoU residues Glu-161, Glu-167, His-162, His-178, and Lys-224 are essential for RNA cleavage, which occurs in the presence of manganese ions.	Histidine	61-64	endonuclease, poly(U) specific like L homeolog	Xenopus laevis	27-33
15755742-5	2005	Specifically, we find that XendoU residues Glu-161, Glu-167, His-162, His-178, and Lys-224 are essential for RNA cleavage, which occurs in the presence of manganese ions.	Histidine	70-73	endonuclease, poly(U) specific like L homeolog	Xenopus laevis	27-33
15942101-4	2005	Direct sequencing revealed that they all had missense mutation in codon 175 (G to A) of arginine switched to histidine, suggesting a germline mutation of TP53.	Histidine	109-118	tumor protein p53	Homo sapiens	154-158
15744050-7	2005	Interestingly, overexpression of PMU1, encoding a potential phosphomutase, partially suppresses the histidine requirement of an ade3 ade16 ade17 triple mutant, most probably by reducing the level of AICAR in this mutant.	Histidine	100-109	putative phosphomutase	Saccharomyces cerevisiae S288C	33-37
15769471-6	2005	Moreover, measurements of rhodopsin containing 13C-labeled histidine show that a strong hydrogen bond between the side-chain of Glu122 and the backbone carbonyl of His211 is disrupted in metarhodopsin II.	Histidine	59-68	rhodopsin	Homo sapiens	26-35
15767264-1	2005	In Arabidopsis thaliana, AUTHENTIC RESPONSE REGULATORS (ARRs) act as downstream components of the His-to-Asp phosphorelay (two-component) signaling pathway that is propagated primarily by the cytokinin receptor kinases, AUTHENTIC HIS-KINASES (AHK2, AHK3 and AHK4/CRE1).	Histidine	98-101	histidine kinase 3	Arabidopsis thaliana	249-253
15653695-3	2005	Previous studies showed that the granulin/epithelin precursor (GEP) binds the histidine-rich region of cyclin T1 and inhibits P-TEFb function.	Histidine	78-87	granulin precursor	Homo sapiens	33-61
15653695-3	2005	Previous studies showed that the granulin/epithelin precursor (GEP) binds the histidine-rich region of cyclin T1 and inhibits P-TEFb function.	Histidine	78-87	granulin precursor	Homo sapiens	63-66
15653695-3	2005	Previous studies showed that the granulin/epithelin precursor (GEP) binds the histidine-rich region of cyclin T1 and inhibits P-TEFb function.	Histidine	78-87	cyclin T1	Homo sapiens	103-112
15878720-7	2005	The increased interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha in diabetic mice were significantly suppressed by the intake of histidine or carnosine (P &lt; 0.05).	Histidine	135-144	interleukin 6	Mus musculus	14-32
15878720-7	2005	The increased interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha in diabetic mice were significantly suppressed by the intake of histidine or carnosine (P &lt; 0.05).	Histidine	135-144	tumor necrosis factor	Mus musculus	37-70
15777792-6	2005	GST-alpha2 and GST-Jun alpha2 bound His-tagged calreticulin while GST-beta1 and GST-Fos beta1 proteins bound talin.	Histidine	36-39	calreticulin	Homo sapiens	47-59
15733928-12	2005	In KAS I, the hydrogen bonding partners are two histidine NE2 atoms, instead of a water and a NE2 side-chain atom in thiolase.	Histidine	48-57	3-oxoacyl-ACP synthase, mitochondrial	Homo sapiens	3-8
15771442-19	2005	The X-ray crystal structures of the ternary complexes 3-thrombin-hirugen and 4-thrombin-hirugen depict novel interactions in the S(1)" region, with the benzothiazole ring forming a hydrogen bond with His-57 and an aromatic stacking interaction with Trp-60D of thrombin"s insertion loop.	Histidine	200-203	coagulation factor II, thrombin	Homo sapiens	56-64
15771442-19	2005	The X-ray crystal structures of the ternary complexes 3-thrombin-hirugen and 4-thrombin-hirugen depict novel interactions in the S(1)" region, with the benzothiazole ring forming a hydrogen bond with His-57 and an aromatic stacking interaction with Trp-60D of thrombin"s insertion loop.	Histidine	200-203	coagulation factor II, thrombin	Homo sapiens	79-87
15771442-19	2005	The X-ray crystal structures of the ternary complexes 3-thrombin-hirugen and 4-thrombin-hirugen depict novel interactions in the S(1)" region, with the benzothiazole ring forming a hydrogen bond with His-57 and an aromatic stacking interaction with Trp-60D of thrombin"s insertion loop.	Histidine	200-203	coagulation factor II, thrombin	Homo sapiens	79-87
15973494-2	2005	The G. orientalis SOD1 (GoSOD1) cDNA contains an open reading frame of 462 bp encoding 154 amino acid polypeptide with a predicted molecular mass of 15.8 kDa and pI of 6.1, and possesses the typical metal binding ligands of six histidines and one aspartic acid common to SOD1s.	Histidine	228-238	superoxide dismutase 1	Apis mellifera	18-22
15812576-9	2005	Furthermore, CAII levels in host cells surrounding GFBP were greatest when phosphorylated, RGD-containing rat His-OPN was adsorbed.	Histidine	110-113	carbonic anhydrase 2	Rattus norvegicus	13-17
15721024-0	2005	Association of apo A-IV 360 (Gln --&gt; His) polymorphism with plasma lipids and lipoproteins: the Framingham Offspring Study.	Histidine	40-43	apolipoprotein A4	Homo sapiens	15-23
15613469-0	2005	Two SUR1-specific histidine residues mandatory for zinc-induced activation of the rat KATP channel.	Histidine	18-27	ATP binding cassette subfamily C member 8	Rattus norvegicus	4-8
15613469-5	2005	Therefore, SUR1 expression is required for the activating action of zinc, which also depended on extracellular pH and was blocked by diethyl pyrocarbonate, suggesting histidine involvement.	Histidine	167-176	ATP binding cassette subfamily C member 8	Rattus norvegicus	11-15
15613469-6	2005	The five SUR1-specific extracellular histidine residues were submitted to site-directed mutagenesis.	Histidine	37-46	ATP binding cassette subfamily C member 8	Rattus norvegicus	9-13
15613469-8	2005	In conclusion, zinc activates KATP by binding itself to extracellular His-326 and His-332 of the SUR1 subunit.	Histidine	70-73	ATP binding cassette subfamily C member 8	Rattus norvegicus	97-101
15613469-8	2005	In conclusion, zinc activates KATP by binding itself to extracellular His-326 and His-332 of the SUR1 subunit.	Histidine	82-85	ATP binding cassette subfamily C member 8	Rattus norvegicus	97-101
15736956-3	2005	However, it was also speculated that the cotransported proton is shared in a H(+)-binding network, possibly involving the conserved histidine 295 in the sixth transmembrane domain of EAAC1.	Histidine	132-141	solute carrier family 1 member 1	Homo sapiens	183-188
15579473-5	2005	We found that GSH inhibited the generation of an approximately 35-kDa C-terminal tryptic fragment (including a C-terminal His tag) termed C2 from MRP1.	Histidine	122-125	ATP binding cassette subfamily C member 1	Homo sapiens	146-150
15809331-12	2005	Thus, Ser(124), His(145) and Asn(196) may be critical for the catalytic function of GDH.	Histidine	16-19	lambda-crystallin	Oryctolagus cuniculus	84-87
15735791-3	2005	Due to the specificity of an inhibitor being influenced by the amino acid residue at the P1 position, we replaced the Arg10 at P1 position of dipetarudin by a histidine, which is the P1 residue of rhodniin, a very specific thrombin inhibitor.	Histidine	159-168	coagulation factor II, thrombin	Homo sapiens	223-231
15713463-11	2005	Since the overall structure of hCNP-CF differs considerably from that of RNase A, it is likely that the similar active sites with two catalytic histidine residues in these enzymes arose through convergent evolution.	Histidine	144-153	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	31-35
15709747-2	2005	A Lys 73 --&gt; His (H73) variant of iso-1-cytochrome c, containing these mutations was used to measure the stability of the Red substructure of cytochrome c through the pH and guanidine hydrochloride (gdnHCl) dependence of the His 73-mediated alkaline conformational transition.	Histidine	16-19	cytochrome c, somatic	Homo sapiens	43-55
15709747-2	2005	A Lys 73 --&gt; His (H73) variant of iso-1-cytochrome c, containing these mutations was used to measure the stability of the Red substructure of cytochrome c through the pH and guanidine hydrochloride (gdnHCl) dependence of the His 73-mediated alkaline conformational transition.	Histidine	16-19	cytochrome c, somatic	Homo sapiens	145-157
15709747-2	2005	A Lys 73 --&gt; His (H73) variant of iso-1-cytochrome c, containing these mutations was used to measure the stability of the Red substructure of cytochrome c through the pH and guanidine hydrochloride (gdnHCl) dependence of the His 73-mediated alkaline conformational transition.	Histidine	228-231	cytochrome c, somatic	Homo sapiens	43-55
15709747-2	2005	A Lys 73 --&gt; His (H73) variant of iso-1-cytochrome c, containing these mutations was used to measure the stability of the Red substructure of cytochrome c through the pH and guanidine hydrochloride (gdnHCl) dependence of the His 73-mediated alkaline conformational transition.	Histidine	228-231	cytochrome c, somatic	Homo sapiens	145-157
15809331-9	2005	Furthermore, we examined the roles of Asp(36), Ser(124), His(145), Glu(157 )and Asn(196) in the catalytic function of rabbit GDH by site-directed mutagenesis.	Histidine	57-60	lambda-crystallin	Oryctolagus cuniculus	125-128
15813610-6	2005	This mutation, is the result of a guanine to adenine transition in codon 855 at position 2926 in exon 7 of the AR gene, which causes an alteration of the coding nucleotide triad from CGC to CAC, which subsequently causes the substitution from arginine to histidine in the amino acid sequence of the receptor protein molecule.	Histidine	255-264	androgen receptor	Homo sapiens	111-113
15737239-0	2005	L-histidine inhibits production of lysophosphatidic acid by the tumor-associated cytokine, autotaxin.	Histidine	0-11	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	91-100
15737239-4	2005	RESULTS: We show that millimolar concentrations of L-histidine inhibit ATX-stimulated but not LPA-stimulated motility in two tumor cell lines, as well as inhibiting enzymatic activities.	Histidine	51-62	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	71-74
15737239-7	2005	Several histidine analogs also inhibit the LPLD activity of ATX; however, none has greater potency than L-histidine and all decrease cell viability or adhesion.	Histidine	8-17	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	60-63
15561724-7	2005	Results suggested that the H-bonding with His-197 inside the nucleotide-binding pocket is critical for NDPK2 functioning.	Histidine	42-45	nucleoside diphosphate kinase 2	Arabidopsis thaliana	103-108
15561724-8	2005	The pH dependence profiles of NDPK2 indicated that mutants with different activities from the wild type have different pK(a) values of His-197 and that NDPK2 hyperactive mutants possess lower pK(a) values.	Histidine	135-138	nucleoside diphosphate kinase 2	Arabidopsis thaliana	30-35
15561724-9	2005	Because a lower pK(a) value of His-197 accelerates NDPK2 autophosphorylation and the phospho-transfer between the phosphorylated NDPK2 and its kinase substrate, we concluded that the Pfr form of phytochrome stimulates NDPK2 by lowering the pK(a) value of His-197.	Histidine	31-34	nucleoside diphosphate kinase 2	Arabidopsis thaliana	51-56
15561724-9	2005	Because a lower pK(a) value of His-197 accelerates NDPK2 autophosphorylation and the phospho-transfer between the phosphorylated NDPK2 and its kinase substrate, we concluded that the Pfr form of phytochrome stimulates NDPK2 by lowering the pK(a) value of His-197.	Histidine	31-34	nucleoside diphosphate kinase 2	Arabidopsis thaliana	129-134
15561724-9	2005	Because a lower pK(a) value of His-197 accelerates NDPK2 autophosphorylation and the phospho-transfer between the phosphorylated NDPK2 and its kinase substrate, we concluded that the Pfr form of phytochrome stimulates NDPK2 by lowering the pK(a) value of His-197.	Histidine	31-34	nucleoside diphosphate kinase 2	Arabidopsis thaliana	129-134
15579906-6	2005	Sequence alignments of CPTI with the acyltransferase family of enzymes in the GenBank led to the identification of a putative catalytic triad in CPTI consisting of residues Cys-305, Asp-454, and His-473.	Histidine	195-198	carnitine palmitoyltransferase 1B	Homo sapiens	23-27
15579906-6	2005	Sequence alignments of CPTI with the acyltransferase family of enzymes in the GenBank led to the identification of a putative catalytic triad in CPTI consisting of residues Cys-305, Asp-454, and His-473.	Histidine	195-198	carnitine palmitoyltransferase 1B	Homo sapiens	145-149
15684398-3	2005	CPSF-73 contains a zinc-binding histidine motif involved in catalysis in other members of the beta-lactamase superfamily, whereas CPSF-100 has substitutions within the histidine motif and thus is unlikely to be catalytically active.	Histidine	32-41	cleavage and polyadenylation specific factor 3	Homo sapiens	0-7
15629146-2	2005	To identify functionally important amino acid residues in CCR2B, we made specific mutations of nine residues selected on the basis of conservation in chemokine receptors and located TM1 (Tyr(49)), TM2 (Leu(95)), TM3 (Thr(117) and Tyr(120)), and TM7 (Ala(286), Thr(290), Glu(291), and His(297)) and in the extracellular loop 3 (Glu(278)).	Histidine	284-287	C-C motif chemokine receptor 2	Homo sapiens	58-63
15629146-4	2005	Reversing the charge at Glu(291) (E291K) and at His(297) (H297D) prevented MCP binding although substitution with Ala at either site had little effect, suggesting that Glu(291) and His(297) probably stabilize TM7 by their ionic interaction.	Histidine	48-51	CD46 molecule	Homo sapiens	75-78
15629146-4	2005	Reversing the charge at Glu(291) (E291K) and at His(297) (H297D) prevented MCP binding although substitution with Ala at either site had little effect, suggesting that Glu(291) and His(297) probably stabilize TM7 by their ionic interaction.	Histidine	181-184	CD46 molecule	Homo sapiens	75-78
15639093-3	2005	A specific plasmid pIVEX2.4c-trxA-shBD2 was constructed for the cell-free expression of fusion protein (hBD2 linked with His-Tag and Trx-Tag).	Histidine	121-124	defensin beta 4A	Homo sapiens	35-39
15629124-6	2005	The iron ligands of soybean lipoxygenase-1 are two His residues in the sequence HWLNTH, one His residue and a distant Asn residue in the sequence HAAVNFGQ, and the C-terminal Ile residue.	Histidine	51-54	seed linoleate 13S-lipoxygenase-1	Glycine max	28-42
15629124-6	2005	The iron ligands of soybean lipoxygenase-1 are two His residues in the sequence HWLNTH, one His residue and a distant Asn residue in the sequence HAAVNFGQ, and the C-terminal Ile residue.	Histidine	92-95	seed linoleate 13S-lipoxygenase-1	Glycine max	28-42
15650878-7	2005	Indeed, the mutation spectrums of purified His-hAID and GST-hAID matched the trinucleotide mutability indexes in Ramos cells and in msh2(-/-)ung(-/-) mice.	Histidine	43-46	uracil DNA glycosylase	Homo sapiens	141-144
16175244-6	2005	Two types of N-terminally His-tagged coat protein constructs were used for the expression in insect cells: one, encoding a 23 kDa protein with the C-terminal amino-acid sequence corresponding to the wild type coat protein and the second with additional clathrin binding domain at the C-terminus.	Histidine	26-29	golgi phosphoprotein 3	Homo sapiens	37-49
15782492-3	2005	MR-1 N-terminal with GST or T7-tag or C-terminal with His-tag, separately, or N terminal with T7-tag and C terminal with His-tag, simultaneously, were fused in plasmids pGEX-5X-1, pET30a (+) , and pET24a (+).	Histidine	54-57	PNKD metallo-beta-lactamase domain containing	Homo sapiens	0-4
15567179-1	2005	The three human SEC14-like proteins TAP1, TAP2, and TAP3 were expressed in Escherichia coli and purified by means of an amino-terminal His-tag.	Histidine	135-138	transporter 1, ATP binding cassette subfamily B member	Homo sapiens	36-40
15665078-7	2005	Sequence homology analysis indicated that, with one exception, the histidine residues that were previously shown to be important for pH sensing by OGR1, GPR4, and TDAG8 were not conserved in the G2A receptor.	Histidine	67-76	G protein-coupled receptor 4	Mus musculus	153-157
15580302-6	2005	The Ipaf promoter was activated by normal p53 but not by His(273) mutant of p53.	Histidine	57-60	NLR family CARD domain containing 4	Homo sapiens	4-8
17252985-6	2005	Melanocortin peptides, proopiomelanocortin (POMC)-derived peptides which have His-Phe-Arg-Trp sequence, are secreted in large amounts in the sympathoinhibitory phase of cardiovascular regulation in shock.	Histidine	78-81	proopiomelanocortin	Homo sapiens	23-42
15651848-4	2005	GSBQ formed adducts with cytochrome c at pH 6 on several histidine and lysine residues.	Histidine	57-66	cytochrome c, somatic	Homo sapiens	25-37
16309371-15	2005	These are close to amino acids that are important for the binding of heme to catalase, 44 (Val) and 72-75 (Arg, Val, Val, His).	Histidine	122-125	catalase	Homo sapiens	77-85
15747502-8	2005	The third epitope is located on the surface of the protein CYP2D6 and displays a hydrophobic patch that is situated between an aromatic residue (W316) and histidine (H326).	Histidine	155-164	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	59-65
17252985-6	2005	Melanocortin peptides, proopiomelanocortin (POMC)-derived peptides which have His-Phe-Arg-Trp sequence, are secreted in large amounts in the sympathoinhibitory phase of cardiovascular regulation in shock.	Histidine	78-81	proopiomelanocortin	Homo sapiens	44-48
15758578-7	2005	The methylation status of fragile histidine triad was associated with that of p14ARF(p=0.021), as was retinoic acid receptor beta--with that of adenomatous polyposis coli 1A (p=0.04).	Histidine	34-43	cyclin dependent kinase inhibitor 2A	Homo sapiens	78-84
15610045-1	2004	The human DNA repair protein, hXRCC1, which is required for DNA single-strand break repair and genetic stability was produced as a histidine-tagged polypeptide in Escherichia coli, purified by affinity chromatography, and subjected to sedimentation and spectroscopic analyses.	Histidine	131-140	X-ray repair cross complementing 6 pseudogene 5	Homo sapiens	10-28
15572383-4	2005	METHODS: Renal ACE activity (Hip-His-Leu cleavage by cortical homogenates) was determined by renal biopsy in 27 adult male Wistar rats.	Histidine	33-36	angiotensin I converting enzyme	Rattus norvegicus	15-18
15709480-4	2005	As revealed by atomic models of the Abeta protofilament, such as the nanotube beta-helix and parallel beta-sheet, the regular arrangement of histidines likely acts as a template for the end-to-end J-aggregation of CR molecules, which produces a red shift in UV/V is absorption.	Histidine	141-151	amyloid beta precursor protein	Homo sapiens	36-41
15610006-5	2004	To resolve whether enhanced activity is directly or indirectly mediated by the variant A8 side chain, we have determined the crystal structure of His(A8)-insulin and investigated the photo-cross-linking properties of an A8 analogue containing p-azidophenylalanine.	Histidine	146-149	insulin	Homo sapiens	154-161
18404403-5	2004	Amino acid substitutions at His-132, located in the third transmembrane domain (TM3) of the hP2Y(1) receptor, delayed the onset of channel opening, but not the kinetics of the activation process.	Histidine	28-31	tropomyosin 3 L homeolog	Xenopus laevis	80-83
15475364-7	2004	Further, the conformational transitions and dynamics of eRF1 and RF2 between the free and ribosome-bound states are most likely controlled by protonation of conserved histidines.	Histidine	167-177	eukaryotic translation termination factor 1	Homo sapiens	56-60
15475364-10	2004	Coulombic interaction strongly favors the open conformation of eRF1; however, solvation and histidine protonation modulate the domain interactions, making the closed conformation of eRF1 more accessible.	Histidine	92-101	eukaryotic translation termination factor 1	Homo sapiens	182-186
15475364-11	2004	Thus, RF1 and RF2 function like molecular machines, most likely fueled by histidine protonation.	Histidine	74-83	mitochondrial translation release factor 1	Homo sapiens	6-9
15584756-2	2004	Recombinant cytochrome c oxidase solubilized in detergent was immobilized on a chemically modified gold surface via the affinity of its histidine-tag to a nickel-chelating nitrilo-triacetic acid (NTA) surface.	Histidine	136-145	cytochrome c, somatic	Homo sapiens	12-24
15588700-8	2004	The formal redox potential of the His/H(2)O complex of cytochrome c in 9 M urea at pH 3 was estimated to be -0.13 V, ca.	Histidine	34-37	cytochrome c, somatic	Homo sapiens	55-67
15613026-6	2004	This novel His-->Tyr substitution was not detected when plasma fibrinogen was analyzed by electrospray ionization mass spectrometry.	Histidine	11-14	fibrinogen beta chain	Homo sapiens	63-73
15613026-10	2004	However, the histidine residue appears critical in maintaining structure of the fibrinogen gammaD domain, rather than in determining function.	Histidine	13-22	fibrinogen beta chain	Homo sapiens	80-90
15557261-4	2004	The ASM model predicts residues Asp 206, Asp 278, Asn 318, His 425, and His 457 to be dimetal coordinating.	Histidine	59-62	sphingomyelin phosphodiesterase 1	Homo sapiens	4-7
15557261-4	2004	The ASM model predicts residues Asp 206, Asp 278, Asn 318, His 425, and His 457 to be dimetal coordinating.	Histidine	72-75	sphingomyelin phosphodiesterase 1	Homo sapiens	4-7
15519763-7	2004	We mutated residues corresponding to nAChR valine 44 in the GABA(A) (alpha(1) histidine 56 and beta(2) valine 53) and glycine (alpha(1) threonine 54) receptors.	Histidine	78-87	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	37-42
15607032-9	2004	Together, our data reveal that the amino acid residues Pro(500) and His(503) are critical for binding of PLC-gamma1 to one of its substrates, PI(4,5)P(2) in the membrane.	Histidine	68-71	phospholipase C gamma 1	Homo sapiens	105-115
15537355-4	2004	Conformational analysis, using experimental constraints derived from NMR studies, indicated that the Tyr(4) and His(6) residues in one of the angiotensin II analogues were in close proximity to each other.	Histidine	112-115	angiotensinogen	Homo sapiens	142-156
15506748-2	2004	In resting cyt c, two endogenous ligands of the heme iron are histidine-18 (His) and methionine-80 (Met) side chains, and NO binding requires the cleavage of one of the axial bonds.	Histidine	62-71	cytochrome c, somatic	Homo sapiens	11-16
15291761-0	2004	Mutational analysis of histidine residues in human organic anion transporter 4 (hOAT4).	Histidine	23-32	solute carrier family 22 member 11	Homo sapiens	51-78
15291761-0	2004	Mutational analysis of histidine residues in human organic anion transporter 4 (hOAT4).	Histidine	23-32	solute carrier family 22 member 11	Homo sapiens	80-85
15291761-2	2004	hOAT4-mediated transport of the organic anion oestrone sulphate in COS-7 cells was inhibited by the histidine-modifying reagent DEPC (diethyl pyrocarbonate).	Histidine	100-109	solute carrier family 22 member 11	Homo sapiens	0-5
15291761-3	2004	Therefore the role of histidine residues in the function of hOAT4 was examined by site-directed mutagenesis.	Histidine	22-31	solute carrier family 22 member 11	Homo sapiens	60-65
15291761-4	2004	All five histidine residues of hOAT4 were converted into alanine, singly or in combination.	Histidine	9-18	solute carrier family 22 member 11	Homo sapiens	31-36
15291761-8	2004	We also showed that, although most of the histidine mutants of hOAT4 were sensitive to inhibition by DEPC, H469A (His-469--&gt;Ala) was completely insensitive to inhibition by this reagent.	Histidine	42-51	solute carrier family 22 member 11	Homo sapiens	63-68
15291761-9	2004	Therefore modification of His-469 is responsible for the inhibition of hOAT4 by DEPC.	Histidine	26-29	solute carrier family 22 member 11	Homo sapiens	71-76
15527800-2	2004	Fluorescence titrations show that the affinity of complex formation of Ca4.CaM with the key 21-residue target peptide increases 1000-fold from pH 9.0 to 4.8, suggesting the involvement of histidine and carboxylic acid residues.	Histidine	188-197	calmodulin 1	Homo sapiens	75-78
15506748-2	2004	In resting cyt c, two endogenous ligands of the heme iron are histidine-18 (His) and methionine-80 (Met) side chains, and NO binding requires the cleavage of one of the axial bonds.	Histidine	76-79	cytochrome c, somatic	Homo sapiens	11-16
15506748-6	2004	The same transient mode was observed for a model ferrous cyt c N-fragment (residues 1-56) ligated with two His in the resting state.	Histidine	107-110	cytochrome c, somatic	Homo sapiens	57-62
15804833-4	2004	As with some plant and bacterial globins, neuroglobin and cytoglobin hemes are hexacoordinate in the absence of external ligands, in that the heme iron atom coordinates both a proximal and a distal His residue.	Histidine	198-201	cytoglobin	Homo sapiens	58-68
15498522-13	2004	We also identified another serine protease fragment that has only the conserved histidine residue.	Histidine	80-89	coagulation factor II, thrombin	Homo sapiens	27-42
15531309-6	2004	Genetic analysis identified a G-->A substitution at nucleotide position 1334 in exon 14 of OPA1 causing an arginine-to-histidine change (R445H) in all affected members of the family.	Histidine	119-128	OPA1 mitochondrial dynamin like GTPase	Homo sapiens	91-95
15299006-2	2004	Two new globin proteins have recently been discovered in vertebrates, neuroglobin in neurons and cytoglobin in all tissues, both showing heme hexacoordination by the distal His(E7) in the absence of gaseous ligands.	Histidine	173-176	cytoglobin	Homo sapiens	97-107
15304513-4	2004	Here we tested whether mice containing the His to Arg point mutation in the alpha1, alpha2, or alpha3 subunit at positions 101, 101, and 126, respectively, which render the respective subunits insensitive to diazepam, would be suitable to analyze this issue.	Histidine	43-46	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	84-101
15451666-10	2004	Curcumin increased Id3-ubiquitin conjugate formation, as shown by Western blotting and His-pull-downs.	Histidine	87-90	inhibitor of DNA binding 3, HLH protein	Homo sapiens	19-22
15368366-10	2004	We expressed these human Gsalpha (hGsalpha) mutants in bacteria as histidine tagged proteins, purified them by niquel-agarose chromatography and studied their nucleotide exchange properties.	Histidine	67-76	GNAS complex locus	Homo sapiens	25-32
15561489-6	2004	Uncoupling protein-1 mRNA in brown adipose tissue increased with increases in dietary histidine.	Histidine	86-95	uncoupling protein 1	Rattus norvegicus	0-20
15453706-0	2004	ACE-inhibitory activity and structural properties of peptide Asp-Lys-Ile-His-Pro [beta-CN f(47-51)].	Histidine	73-76	angiotensin I converting enzyme	Homo sapiens	0-3
15368366-10	2004	We expressed these human Gsalpha (hGsalpha) mutants in bacteria as histidine tagged proteins, purified them by niquel-agarose chromatography and studied their nucleotide exchange properties.	Histidine	67-76	GNAS complex locus	Homo sapiens	34-42
15377163-8	2004	When HSA was incubated with MCI without GSH, three peptides modified at histidine residues were characterized while when HSA was incubated in the presence of GSH, five peptides modified at histidine and lysine residues were identified.	Histidine	72-81	albumin	Homo sapiens	5-8
15556297-3	2004	PAPA-1 was found to be localized in the nucleolus in transfected HeLa cells, and the lysine/histidine cluster was essential for nucleolar localization of PAPA-1.	Histidine	92-101	INO80 complex subunit B	Homo sapiens	154-160
15234970-7	2004	At a Ca(2+)(o) of 1.1 mm and an amino acid concentration of 1 mm, CaR-active amino acids (l-Phe = l-Trp &gt; l-His = l-Ala), but not CaR-inactive amino acids (l-Leu and l-Arg), stereoselectively suppressed PTH secretion by up to 40%, similar to the effect of raising Ca(2+)(o) to 1.2 mm.	Histidine	109-114	calcium sensing receptor	Homo sapiens	66-69
15377163-8	2004	When HSA was incubated with MCI without GSH, three peptides modified at histidine residues were characterized while when HSA was incubated in the presence of GSH, five peptides modified at histidine and lysine residues were identified.	Histidine	189-198	albumin	Homo sapiens	5-8
15194703-3	2004	We report the identification of a high-affinity zinc coordination site within the transmembrane domain of rhodopsin, coordinated by the side chains of two highly conserved residues, Glu(122) in transmembrane helix III and His(211) in transmembrane helix V. We also demonstrate that this zinc coordination is critical for rhodopsin folding, 11-cis-retinal binding, and the stability of the chromophore-receptor interaction, defects of which are observed in retinitis pigmentosa.	Histidine	222-225	rhodopsin	Homo sapiens	106-115
15331542-2	2004	The protein (369 amino acids) predicted from this gene, ZnT-8, contains six transmembrane domains and a histidine-rich loop between transmembrane domains IV and V, like the other ZnT proteins.	Histidine	104-113	solute carrier family 30 member 8	Homo sapiens	56-61
15612483-8	2004	The fourth module is the most active one which has a histidine-rich region (His204-His257) on the surface of SELP.	Histidine	53-62	selenoprotein P	Homo sapiens	109-113
15273322-4	2004	DcpS is a member of the histidine triad (HIT) family of hydrolases and catalyzes the cleavage of m7GpppN.	Histidine	24-33	decapping enzyme, scavenger	Homo sapiens	0-4
15326290-7	2004	The corresponding histidine in cytochrome c oxidases is along a major electron transfer pathway from CuA center to heme a.	Histidine	18-27	cytochrome c, somatic	Homo sapiens	31-43
15181008-3	2004	Mutation of His-10 in PGM abolishes the Nm23-H1.GAPDH complex-induced phosphorylation.	Histidine	12-15	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	48-53
15194703-3	2004	We report the identification of a high-affinity zinc coordination site within the transmembrane domain of rhodopsin, coordinated by the side chains of two highly conserved residues, Glu(122) in transmembrane helix III and His(211) in transmembrane helix V. We also demonstrate that this zinc coordination is critical for rhodopsin folding, 11-cis-retinal binding, and the stability of the chromophore-receptor interaction, defects of which are observed in retinitis pigmentosa.	Histidine	222-225	rhodopsin	Homo sapiens	321-330
15358233-5	2004	Furthermore, His-p53 and FLAG-XPG, but not PCNA, stimulated the Tg DNA glycosylase/AP lyase activity of GST-NTH1 or NTH1.	Histidine	13-16	tumor protein p53	Homo sapiens	17-20
15256223-3	2004	APC11 contains a RING-H2-finger domain, which includes one histidine and seven cysteine residues that coordinate two Zn(2+) ions.	Histidine	59-68	anaphase promoting complex subunit 11	Homo sapiens	0-5
15289101-1	2004	Human neuron-specific enolase (NSE) or isozyme gamma has been expressed with a C-terminal His-tag in Escherichia coli.	Histidine	90-93	enolase 2	Homo sapiens	31-34
15192104-4	2004	Mutation of Vhs3 His(459), equivalent to the supposedly functionally relevant His(90) in the plant homolog AtHal3a, did not affect Vhs3 functions mentioned above.	Histidine	17-20	phosphopantothenoylcysteine decarboxylase complex subunit VHS3	Saccharomyces cerevisiae S288C	12-16
15272307-1	2004	Mammalian formiminotransferase cyclodeaminase (FTCD), a 0.5 million Dalton homo-octameric enzyme, plays important roles in coupling histidine catabolism with folate metabolism and integrating the Golgi complex with the vimentin intermediate filament cytoskeleton.	Histidine	132-141	formimidoyltransferase cyclodeaminase	Homo sapiens	10-45
15272307-1	2004	Mammalian formiminotransferase cyclodeaminase (FTCD), a 0.5 million Dalton homo-octameric enzyme, plays important roles in coupling histidine catabolism with folate metabolism and integrating the Golgi complex with the vimentin intermediate filament cytoskeleton.	Histidine	132-141	formimidoyltransferase cyclodeaminase	Homo sapiens	47-51
15274636-5	2004	Furthermore, the cytochrome c with His and Met residues as the axial ligands exhibited redox potentials increased by only 15-30 mV in comparison with the cytochrome with the bis-His coordination.	Histidine	35-38	cytochrome c, somatic	Homo sapiens	17-29
15305013-1	2004	Secretory phospholipase A2 (sPLA2) is a growing family of structurally related, disulfide-rich, low molecular weight, lipolytic enzymes with a His-Asp catalytic dyad.	Histidine	143-146	phospholipase A2 group X	Homo sapiens	0-26
15305013-1	2004	Secretory phospholipase A2 (sPLA2) is a growing family of structurally related, disulfide-rich, low molecular weight, lipolytic enzymes with a His-Asp catalytic dyad.	Histidine	143-146	phospholipase A2 group X	Homo sapiens	28-33
15287859-1	2004	BACKGROUND: Histidinaemia is an autosomal recessive disorder affecting the hepatic enzyme histidine ammonia lyase (histidase) resulting in elevated plasma and urinary histidine and is prototypic of a series of hepatic cytosolic enzyme defects.	Histidine	90-99	histidine ammonia lyase	Mus musculus	115-124
15276160-0	2004	Modification of Cytochrome c by 4-hydroxy- 2-nonenal: evidence for histidine, lysine, and arginine-aldehyde adducts.	Histidine	67-76	cytochrome c, somatic	Homo sapiens	16-28
15304042-8	2004	Moreover, the existence of a subsequent disulfide-linked Cys in gamma 275C fibrinogen augments the impairment caused by a His or Ala substitution.	Histidine	122-125	fibrinogen beta chain	Homo sapiens	75-85
15263070-7	2004	A beta((1-40)) and A beta((1-42)) induced a redshift of 15-20 nm in the spectrum of heme-b and heme-a, suggesting that heme binds A beta, likely to one or more of the histidine residues.	Histidine	167-176	amyloid beta precursor protein	Homo sapiens	0-6
15123612-7	2004	Both proton ((1)H) and nitrogen ((14)N) ENDOR studies of bSOD1 and hSOD1 in the presence of H(2)O(2) revealed a change in the geometry of His-46 (or His-44) and His-48 (or His-46) coordinated to Cu(II) at the active site of WT hSOD1 and bSOD1, respectively.	Histidine	138-141	superoxide dismutase 1	Homo sapiens	67-72
15123612-7	2004	Both proton ((1)H) and nitrogen ((14)N) ENDOR studies of bSOD1 and hSOD1 in the presence of H(2)O(2) revealed a change in the geometry of His-46 (or His-44) and His-48 (or His-46) coordinated to Cu(II) at the active site of WT hSOD1 and bSOD1, respectively.	Histidine	138-141	superoxide dismutase 1	Homo sapiens	227-232
15123612-7	2004	Both proton ((1)H) and nitrogen ((14)N) ENDOR studies of bSOD1 and hSOD1 in the presence of H(2)O(2) revealed a change in the geometry of His-46 (or His-44) and His-48 (or His-46) coordinated to Cu(II) at the active site of WT hSOD1 and bSOD1, respectively.	Histidine	149-152	superoxide dismutase 1	Homo sapiens	67-72
15123612-7	2004	Both proton ((1)H) and nitrogen ((14)N) ENDOR studies of bSOD1 and hSOD1 in the presence of H(2)O(2) revealed a change in the geometry of His-46 (or His-44) and His-48 (or His-46) coordinated to Cu(II) at the active site of WT hSOD1 and bSOD1, respectively.	Histidine	149-152	superoxide dismutase 1	Homo sapiens	67-72
15123612-7	2004	Both proton ((1)H) and nitrogen ((14)N) ENDOR studies of bSOD1 and hSOD1 in the presence of H(2)O(2) revealed a change in the geometry of His-46 (or His-44) and His-48 (or His-46) coordinated to Cu(II) at the active site of WT hSOD1 and bSOD1, respectively.	Histidine	149-152	superoxide dismutase 1	Homo sapiens	67-72
15263070-7	2004	A beta((1-40)) and A beta((1-42)) induced a redshift of 15-20 nm in the spectrum of heme-b and heme-a, suggesting that heme binds A beta, likely to one or more of the histidine residues.	Histidine	167-176	amyloid beta precursor protein	Homo sapiens	19-25
15263070-7	2004	A beta((1-40)) and A beta((1-42)) induced a redshift of 15-20 nm in the spectrum of heme-b and heme-a, suggesting that heme binds A beta, likely to one or more of the histidine residues.	Histidine	167-176	amyloid beta precursor protein	Homo sapiens	19-25
15257610-4	2004	To restrict the observed conformational flexibility, a mutant F3 (mF3), which differs from F3 in the number and type of amino acids between the cysteine and the histidine ligands, was synthesized.	Histidine	161-170	coagulation factor III	Mus musculus	62-64
15257610-4	2004	To restrict the observed conformational flexibility, a mutant F3 (mF3), which differs from F3 in the number and type of amino acids between the cysteine and the histidine ligands, was synthesized.	Histidine	161-170	coagulation factor III	Mus musculus	66-69
15257610-4	2004	To restrict the observed conformational flexibility, a mutant F3 (mF3), which differs from F3 in the number and type of amino acids between the cysteine and the histidine ligands, was synthesized.	Histidine	161-170	coagulation factor III	Mus musculus	67-69
15257610-9	2004	The(113)Cd ion in (113)Cd-mF3 is coupled to the protons of two cysteine and two histidine residues and characterized by a chemical shift of 567 ppm.	Histidine	80-89	coagulation factor III	Mus musculus	26-29
15256063-7	2004	Hint/PKCI-1, which is the only other characterized human histidine triad (HIT) nucleotide-binding protein in addition to tumor-suppressor gene FHIT, might be involved in lung carcinogenesis.	Histidine	57-66	histidine triad nucleotide binding protein 1	Homo sapiens	0-4
15256063-7	2004	Hint/PKCI-1, which is the only other characterized human histidine triad (HIT) nucleotide-binding protein in addition to tumor-suppressor gene FHIT, might be involved in lung carcinogenesis.	Histidine	57-66	histidine triad nucleotide binding protein 1	Homo sapiens	5-11
15326283-5	2004	In the wild-type insulin, binding of zinc ions by B10 His overcomes this problem, whereas in the B10 mutant this possibility is ruled out by the absence of the zinc binding site.	Histidine	54-57	insulin	Homo sapiens	17-24
15717658-5	2004	The analysis revealed a heterozygous mutation in exon 4 of the MEN 1 gene: a G to A missense mutation at codon 229 (CGC--&gt;CAC), which changes arginine to histidine.	Histidine	157-166	menin 1	Homo sapiens	63-68
15138608-9	2004	JD2H domain with C2HC2HC2- and C5HC2-type Cys (His) clusters was identified as the region conserved among JMJD2A (1064 aa), JMJD2B (1096 aa), and JMJD2C (1056 aa) proteins.	Histidine	47-50	lysine demethylase 4B	Homo sapiens	124-130
15276452-2	2004	In this study, recombinant native AtPAL1, 2, and 4 were demonstrated to be catalytically competent for l-phenylalanine deamination, whereas AtPAL3, obtained as a N-terminal His-tagged protein, was of very low activity and only detectable at high substrate concentrations.	Histidine	173-176	phenyl alanine ammonia-lyase 3	Arabidopsis thaliana	140-146
15147208-3	2004	In leghemoglobin, the imidazole side chain of His(E7) is confined to a single conformation, which only weakly hydrogen bonds to bound ligands.	Histidine	46-49	leghemoglobin A	Glycine max	3-16
15146486-8	2004	In particular, the presence of histidine residues in the interface gives a structural basis for the pH-regulated release mechanism of apoE in the endosomes.	Histidine	31-40	apolipoprotein E	Homo sapiens	134-138
15469714-7	2004	When Cu,Zn-SOD that had been exposed to catecholamines was subsequently analyzed by an amino acid analysis, the glycine and histidine residues were particularly sensitive.	Histidine	124-133	superoxide dismutase 1	Homo sapiens	11-14
15135396-6	2004	Proteins were purified as the p85alpha/p110 complex by nickel affinity chromatography through an N-terminal His-tag on the p110 subunit using an imidazole gradient.	Histidine	108-111	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	30-38
15031290-6	2004	Using site-directed mutagenesis, we identified 2 histidine residues, His-243 in the large second extracellular loop (ECL2) and His-410 in the fourth extracellular loop (ECL4), as two coordinates in the Zn2+ binding site of GLYT1b.	Histidine	49-58	solute carrier family 6 member 9 S homeolog	Xenopus laevis	223-229
15031290-6	2004	Using site-directed mutagenesis, we identified 2 histidine residues, His-243 in the large second extracellular loop (ECL2) and His-410 in the fourth extracellular loop (ECL4), as two coordinates in the Zn2+ binding site of GLYT1b.	Histidine	69-72	solute carrier family 6 member 9 S homeolog	Xenopus laevis	223-229
15031290-6	2004	Using site-directed mutagenesis, we identified 2 histidine residues, His-243 in the large second extracellular loop (ECL2) and His-410 in the fourth extracellular loop (ECL4), as two coordinates in the Zn2+ binding site of GLYT1b.	Histidine	127-130	solute carrier family 6 member 9 S homeolog	Xenopus laevis	223-229
15031290-7	2004	In addition, our study suggests that the molecular determinants of proton regulation of GLYT1b are localized to the 2 histidine residues (His-410 and His-421) of ECL4.	Histidine	118-127	solute carrier family 6 member 9 S homeolog	Xenopus laevis	88-94
15031290-7	2004	In addition, our study suggests that the molecular determinants of proton regulation of GLYT1b are localized to the 2 histidine residues (His-410 and His-421) of ECL4.	Histidine	138-141	solute carrier family 6 member 9 S homeolog	Xenopus laevis	88-94
15031290-7	2004	In addition, our study suggests that the molecular determinants of proton regulation of GLYT1b are localized to the 2 histidine residues (His-410 and His-421) of ECL4.	Histidine	150-153	solute carrier family 6 member 9 S homeolog	Xenopus laevis	88-94
15147208-6	2004	Thus, high oxygen affinity in leghemoglobin is established by a favorable staggered geometry of the proximal histidine.	Histidine	109-118	leghemoglobin A	Glycine max	30-43
15335045-1	2004	The antigenic protein Ro52 was expressed in the E. coli system harboring a 6 x His tag in the form of insoluble inclusion bodies.	Histidine	79-82	tripartite motif containing 21	Homo sapiens	22-26
15111055-8	2004	Together with previous crystal structure data, the new functional data provide a mechanistic understanding of the conserved histidine, lysine and asparagine residues found among all PLD family members.	Histidine	124-133	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	182-185
15252643-2	2004	[Co(tren)(histidine)](2+) 1 crystallizes in the enantiomorphic space group P2(1)2(1)2(1) and 2 crystallizes in the P2(1)/c space group.	Histidine	10-19	cyclin dependent kinase inhibitor 1A	Homo sapiens	75-80
15078916-9	2004	Alkaline pH increased the water permeability of AQP4 that contains His at position 129 in loop C. Acid and alkaline pH sensitivity was induced in AQP1 by adding histidines 48 (in loop A) and 130 (in loop C).	Histidine	67-70	aquaporin 1	Bos taurus	146-150
15078916-9	2004	Alkaline pH increased the water permeability of AQP4 that contains His at position 129 in loop C. Acid and alkaline pH sensitivity was induced in AQP1 by adding histidines 48 (in loop A) and 130 (in loop C).	Histidine	161-171	aquaporin 1	Bos taurus	146-150
15185439-2	2004	the mutations responsible are located in the CACNA1S gene (type 1) and in the SCN4A gene (type 2), and are all missense mutations where arginine is mostly replaced by histidine or sometimes glycine.	Histidine	167-176	calcium voltage-gated channel subunit alpha1 S	Homo sapiens	45-52
15161530-6	2004	METHODS: Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was performed to find mEH polymorphism in exon 3 (Tyr113--&gt;His), exon 4 (His139--&gt;Arg) and GSTP1 polymorphism in exon 5 (Ile105--&gt;Val) in 100 COPD patients and 100 age- and sex-matched healthy controls.	Histidine	149-152	epoxide hydrolase 1, microsomal	Mus musculus	109-112
15113898-3	2004	Extensions with six and nine His residues but not with fewer than six His residues were found to severely inhibit virus replication through decreased Env electrophoretic mobility and reduced Env incorporation compared to the wild-type virus.	Histidine	29-32	endogenous retrovirus group W member 1, envelope	Homo sapiens	150-153
15971602-2	2004	After sequencing, the gene was cloned into prokaryotic expression vector pTIG-Trx which carried thioredoxin (Trx) gene and a C-terminal His.tag.	Histidine	136-139	thioredoxin 1	Rattus norvegicus	78-81
15084118-13	2004	Furthermore, when the His-DPhe-Arg-Trp sequence is used to replace the hAGRP Arg-Phe-Phe residues in the "mini"-AGRP (hAGRP87-120, C105A) template, a potent nanomolar agonist resulted at the mMC1R and MC3-5Rs.	Histidine	22-25	agouti related neuropeptide	Mus musculus	72-76
14978032-7	2004	Competition studies with glycine and l-histidine indicate that copper binds to Abeta-(1-28) at pH 7.4 with an affinity of K(a) approximately 10(7) m(-1).	Histidine	37-48	amyloid beta precursor protein	Homo sapiens	79-84
14978032-9	2004	Studies using analogues of Abeta-(1-28) in which each of the histidine residues have been replaced by alanine or in which the N terminus is acetylated suggest that the N terminus and His(13) are crucial for Cu(2+) binding and that His(6) and His(14) are also implicated.	Histidine	61-70	amyloid beta precursor protein	Homo sapiens	27-32
14978032-9	2004	Studies using analogues of Abeta-(1-28) in which each of the histidine residues have been replaced by alanine or in which the N terminus is acetylated suggest that the N terminus and His(13) are crucial for Cu(2+) binding and that His(6) and His(14) are also implicated.	Histidine	183-186	amyloid beta precursor protein	Homo sapiens	27-32
14978032-9	2004	Studies using analogues of Abeta-(1-28) in which each of the histidine residues have been replaced by alanine or in which the N terminus is acetylated suggest that the N terminus and His(13) are crucial for Cu(2+) binding and that His(6) and His(14) are also implicated.	Histidine	231-234	amyloid beta precursor protein	Homo sapiens	27-32
14978032-9	2004	Studies using analogues of Abeta-(1-28) in which each of the histidine residues have been replaced by alanine or in which the N terminus is acetylated suggest that the N terminus and His(13) are crucial for Cu(2+) binding and that His(6) and His(14) are also implicated.	Histidine	231-234	amyloid beta precursor protein	Homo sapiens	27-32
15096035-1	2004	Cu-Zn superoxide dismutase (SOD) contains a conserved, metal-free His residue at an opening of the backbone beta-barrel in addition to six Cu- and/or Zn-bound His residues in the active site.	Histidine	66-69	superoxide dismutase 1	Homo sapiens	28-31
15096035-1	2004	Cu-Zn superoxide dismutase (SOD) contains a conserved, metal-free His residue at an opening of the backbone beta-barrel in addition to six Cu- and/or Zn-bound His residues in the active site.	Histidine	159-162	superoxide dismutase 1	Homo sapiens	28-31
15096035-2	2004	We examined the protonation and hydrogen bonding state of the metal-free His residue (His41) in bovine SOD by UV Raman spectroscopy.	Histidine	73-76	superoxide dismutase 1	Homo sapiens	103-106
15043985-6	2004	Full-length human genes for HDAC1 and HDAC3 were cloned into the pcDNA 3.1 vector containing a N-terminal His-tag with an enterokinase cleavage site.	Histidine	106-109	histone deacetylase 1	Homo sapiens	28-33
15003262-3	2004	Toward this end, APG8a fused to an N-terminal His-tag has been expressed in Escherichia coli under a T7 expression system, refolded in vitro, and kept soluble by slight destabilization.	Histidine	46-49	Ubiquitin-like superfamily protein	Arabidopsis thaliana	17-22
14715082-6	2004	Histidine limitation caused an increase in the phosphorylation of ERK1/ERK2 (extracellular-signal-regulated kinase), and inhibition of the ERK signal transduction pathway resulted in a reduction in the starvation-dependent increase in p21 mRNA.	Histidine	0-9	mitogen-activated protein kinase 3	Homo sapiens	66-70
14715082-6	2004	Histidine limitation caused an increase in the phosphorylation of ERK1/ERK2 (extracellular-signal-regulated kinase), and inhibition of the ERK signal transduction pathway resulted in a reduction in the starvation-dependent increase in p21 mRNA.	Histidine	0-9	mitogen-activated protein kinase 1	Homo sapiens	71-75
14715082-6	2004	Histidine limitation caused an increase in the phosphorylation of ERK1/ERK2 (extracellular-signal-regulated kinase), and inhibition of the ERK signal transduction pathway resulted in a reduction in the starvation-dependent increase in p21 mRNA.	Histidine	0-9	mitogen-activated protein kinase 3	Homo sapiens	66-69
15359534-2	2004	Several experimental interventions have shown that common variations at residues 347 (Thr --&gt; Ser) and 360 (Gln --&gt; His) on apoA4 are associated with differences in plasma lipid response to dietary fat; however, association studies between these variants and plasma lipid concentrations in populations reveal mixed results.	Histidine	122-125	apolipoprotein A4	Homo sapiens	130-135
15036381-1	2004	Histidinemia is an inherited metabolic disorder caused by deficiency of histidase activity, which leads to tissue accumulation of histidine and its derivatives.	Histidine	130-139	histidine ammonia lyase	Rattus norvegicus	72-81
15036381-5	2004	We observed that l-histidine provoked an increase of chemiluminescence and a reduction of TRAP at concentrations of 2.5 mM and higher, while TBA-RS measurement, GSH-Px, CAT and SOD activities were not affected.	Histidine	17-28	catalase	Rattus norvegicus	169-172
15168591-2	2004	In 1996 the fragile histidine triad (FHIT) gene was isolated from the region encompassing the most active fragile FRA3B locus, and recently the WW domain-containing oxidoreductase gene (WWOX) was identified at FRA16D.	Histidine	20-29	WW domain containing oxidoreductase	Homo sapiens	186-190
14744150-4	2004	Use of an 8-azido[alpha-(32)P]ATP-binding and vanadate-trapping assay allowed us to devise conditions to preserve CFTR function during purification of a C-terminal His(10)-tagged variant after solubilization with lysophosphatidylglycerol (1%) and diheptanoylphosphatidylcholine (0.3%) in the presence of excess phospholipid.	Histidine	164-167	CF transmembrane conductance regulator	Homo sapiens	114-118
14595564-5	2004	Supine ACE levels were dependent upon ACE genotype [24.8 (5.7), 26.9 (4.5), 45.5 (6.4) nmol His-Leu ml(-1) min(-1); II, ID, DD, respectively; P&lt;0.00005] and thereafter.	Histidine	92-95	angiotensin I converting enzyme	Homo sapiens	7-10
14595564-5	2004	Supine ACE levels were dependent upon ACE genotype [24.8 (5.7), 26.9 (4.5), 45.5 (6.4) nmol His-Leu ml(-1) min(-1); II, ID, DD, respectively; P&lt;0.00005] and thereafter.	Histidine	92-95	angiotensin I converting enzyme	Homo sapiens	38-41
15012592-0	2004	N-terminal His(7)-modification of glucagon-like peptide-1(7-36) amide generates dipeptidyl peptidase IV-stable analogues with potent antihyperglycaemic activity.	Histidine	11-14	glucagon	Homo sapiens	34-57
14766304-2	2004	A full-length light chain for the type E neurotoxin with a C-terminal 6x His-tag, BoNT/E-LC, has been cloned in a pET-9c vector and over-expressed in BL21 (DE3) cells.	Histidine	73-76	neurotoxin	Clostridium botulinum	41-51
14625295-5	2004	Substitutions of Thr-383 (histidine in most PGHS-1) with histidine or aspartate decreased cyclooxygenase activation efficiency by about 40%, with little effect on cyclooxygenase specific activity or self-inactivation.	Histidine	26-35	prostaglandin-endoperoxide synthase 1	Homo sapiens	44-50
15003527-5	2004	The recombinant human 6x His-PC isolated with a purity of approximately 50% using a Ni-NTA agarose column was found to have the specific activity of 7U/mg, which was similar to that produced from a 293T stable line [Biochem.	Histidine	25-28	pyruvate carboxylase	Homo sapiens	29-31
15023064-0	2004	Is aromaticity essential for trapping the catalytic histidine 447 in human acetylcholinesterase?	Histidine	52-61	acetylcholinesterase (Cartwright blood group)	Homo sapiens	75-95
15023064-1	2004	Replacement of both the acyl pocket residue Phe295 as well as residue Phe338, adjacent to the catalytic His447 in human acetylcholinesterase (HuAChE), resulted in a 680-fold decline in catalytic activity due to conformational destabilization of the histidine side chain [Barak et al.	Histidine	249-258	acetylcholinesterase (Cartwright blood group)	Homo sapiens	120-140
15134829-2	2004	The low-K(d) insulin analogues [His(A8),His(B4), Glu(B10),His(B27)]-human insulin (-HI) (the H2-analogue), [Asp(B10)]HI and [Glu(A13),Glu(B10)]HI, were studied in liver parenchymal cells and compared with wild-type HI and epidermal growth factor (EGF), a mitogenic inducer.	Histidine	32-35	insulin	Homo sapiens	74-81
15134829-2	2004	The low-K(d) insulin analogues [His(A8),His(B4), Glu(B10),His(B27)]-human insulin (-HI) (the H2-analogue), [Asp(B10)]HI and [Glu(A13),Glu(B10)]HI, were studied in liver parenchymal cells and compared with wild-type HI and epidermal growth factor (EGF), a mitogenic inducer.	Histidine	40-43	insulin	Homo sapiens	74-81
15134829-2	2004	The low-K(d) insulin analogues [His(A8),His(B4), Glu(B10),His(B27)]-human insulin (-HI) (the H2-analogue), [Asp(B10)]HI and [Glu(A13),Glu(B10)]HI, were studied in liver parenchymal cells and compared with wild-type HI and epidermal growth factor (EGF), a mitogenic inducer.	Histidine	40-43	insulin	Homo sapiens	74-81
14733927-4	2004	The change in the transient absorption spectrum by interaction with trityrosine was similar to that obtained with 100 mM imidazole, which showed that the population of the intermediate His/His coordinated species increased during folding of cyt c by interaction with trityrosine.	Histidine	185-188	cytochrome c, somatic	Homo sapiens	241-246
14733927-4	2004	The change in the transient absorption spectrum by interaction with trityrosine was similar to that obtained with 100 mM imidazole, which showed that the population of the intermediate His/His coordinated species increased during folding of cyt c by interaction with trityrosine.	Histidine	189-192	cytochrome c, somatic	Homo sapiens	241-246
14729063-4	2004	When human prostate carcinoma DU145 cells were treated with 200 ng/ml His-tagged TRAIL for 4 h, the survival was approximately 10% at pH 6.3-6.6 and 61.3% at pH 7.4.	Histidine	70-73	TNF superfamily member 10	Homo sapiens	81-86
14570889-6	2004	Alkaline hydrolysis of serum albumin also revealed two acid-labile malondialdehyde adducts of histidine in significant quantities, the isomers 4- and 2-ethylidene-histidine.	Histidine	94-103	albumin	Homo sapiens	29-36
14762077-10	2004	Ratio of blood AA uptake to milk protein output increased significantly for His, Met, and Leu.	Histidine	76-79	casein beta	Bos taurus	28-40
14717612-1	2004	We have previously reported that amyloid Abeta, the major component of senile plaques in Alzheimer"s disease (AD), binds Cu with high affinity via histidine and tyrosine residues [Atwood, C. S., et al.	Histidine	147-156	amyloid beta precursor protein	Homo sapiens	41-46
14570889-0	2004	Identification of a new cross-link and unique histidine adduct from bovine serum albumin incubated with malondialdehyde.	Histidine	46-55	albumin	Homo sapiens	81-88
14711628-6	2004	The OmpT variants with leucine and histidine at position 97 were useful in releasing human adrenocorticotropic hormone (1-24) (serine at the N terminus) and human calcitonin precursor (cysteine at the N terminus), respectively, from fusion proteins.	Histidine	35-44	calcitonin related polypeptide alpha	Homo sapiens	163-173
14560963-3	2004	Ser2481, which is located in a His-Ser-Phe motif near the conserved carboxyl-terminal mTOR tail, has been reported as an autophosphorylation site in vivo and in vitro.	Histidine	31-34	mechanistic target of rapamycin kinase	Homo sapiens	86-90
14530264-1	2003	Neuroglobin and cytoglobin reversibly bind oxygen in competition with the distal histidine, and the observed oxygen affinity therefore depends on the properties of both ligands.	Histidine	81-90	cytoglobin	Homo sapiens	16-26
14659886-1	2003	Human zinc-fingers and homeoboxes (ZHX) 1, ZHX2 and ZHX3, members of the ZHX family, contain two Cys(2)-His(2)-type zinc-finger motifs and five homeodomains (HDs).	Histidine	104-107	zinc fingers and homeoboxes 1	Mus musculus	6-41
14659886-1	2003	Human zinc-fingers and homeoboxes (ZHX) 1, ZHX2 and ZHX3, members of the ZHX family, contain two Cys(2)-His(2)-type zinc-finger motifs and five homeodomains (HDs).	Histidine	104-107	zinc fingers and homeoboxes 2	Mus musculus	43-47
14522955-0	2003	Identification of an N-domain histidine essential for chaperone function in calreticulin.	Histidine	30-39	calreticulin	Homo sapiens	76-88
14662886-6	2003	Among the HXYLPM analogues, His-Arg-Tyr-Leu-Pro-Met (HRYLPM) activated a broad spectrum of cellular signaling events, including an intracellular Ca(2+) concentration increase, phosphoinositide 3-kinase, extracellular signal-regulated kinase, and Akt activation, however, His-Glu-Tyr-Leu-Pro-Met (HEYLPM) activated only intracellular Ca(2+) concentration and Akt but did not increase Ca(2+).	Histidine	28-31	AKT serine/threonine kinase 1	Homo sapiens	246-249
14662886-6	2003	Among the HXYLPM analogues, His-Arg-Tyr-Leu-Pro-Met (HRYLPM) activated a broad spectrum of cellular signaling events, including an intracellular Ca(2+) concentration increase, phosphoinositide 3-kinase, extracellular signal-regulated kinase, and Akt activation, however, His-Glu-Tyr-Leu-Pro-Met (HEYLPM) activated only intracellular Ca(2+) concentration and Akt but did not increase Ca(2+).	Histidine	28-31	AKT serine/threonine kinase 1	Homo sapiens	358-361
14522955-2	2003	We reconstituted ER of calreticulin-deficient cells with N-terminal histidine (His25, His82, His128, and His153) calreticulin mutants and carried out a functional analysis.	Histidine	68-77	calreticulin	Homo sapiens	23-35
14753756-9	2003	Noteworthy, ascorbate/Cu2+-inactivated PON1, which was charaterized by the partial loss of histidine residues, expressed a lower protection against Cu2+-induced LDL oxidation, compared to native PON1.	Histidine	91-100	paraoxonase 1	Homo sapiens	39-43
14506238-7	2003	In this study, we found that the amino acid sequence His-Gly-Lys (HGK) in D5H is the core motif for inhibition of adhesion and invasion of MDA-MB-231 cells in vitro.	Histidine	53-56	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	66-69
14696916-1	2003	The recombinant human thyroid hormone receptor (TR) was expressed as an in-frame fusion with ten consecutive histidine residues using a bacterial system; then the receptor was immobilized on an Au-electrode with Ni(II)-mediated chemisorption using the histidine tag and thiol-modified nitrilotriacetic acid.	Histidine	109-118	telomerase RNA component	Homo sapiens	48-50
14696916-1	2003	The recombinant human thyroid hormone receptor (TR) was expressed as an in-frame fusion with ten consecutive histidine residues using a bacterial system; then the receptor was immobilized on an Au-electrode with Ni(II)-mediated chemisorption using the histidine tag and thiol-modified nitrilotriacetic acid.	Histidine	252-261	telomerase RNA component	Homo sapiens	48-50
14584938-5	2003	The absence of this COX-2 secondary pocket in the COX-1 binding site is due to the presence of the bulky Ile(523) in COX-1 such that access to the amino acid residues (Ile(517), Phe(518), Gln(192), and His(90)), which line the COX-2 secondary pocket with which the SO(2)Me pharmacophore could interact, is hindered.	Histidine	202-205	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	50-55
14621986-4	2003	Thus, His-15, His-25, Cys-84, His-85, and perhaps His-90 of S100B are involved in coordinating Zn(2+), which was confirmed by NMR spectroscopy.	Histidine	6-9	S100 calcium binding protein B	Homo sapiens	60-65
14621986-4	2003	Thus, His-15, His-25, Cys-84, His-85, and perhaps His-90 of S100B are involved in coordinating Zn(2+), which was confirmed by NMR spectroscopy.	Histidine	14-17	S100 calcium binding protein B	Homo sapiens	60-65
14621986-4	2003	Thus, His-15, His-25, Cys-84, His-85, and perhaps His-90 of S100B are involved in coordinating Zn(2+), which was confirmed by NMR spectroscopy.	Histidine	14-17	S100 calcium binding protein B	Homo sapiens	60-65
14621986-4	2003	Thus, His-15, His-25, Cys-84, His-85, and perhaps His-90 of S100B are involved in coordinating Zn(2+), which was confirmed by NMR spectroscopy.	Histidine	14-17	S100 calcium binding protein B	Homo sapiens	60-65
14584947-3	2003	To probe the receptor active conformation of the pharmacophore His-Phe-Arg-Trp in gamma-MSH, two different series of gamma-MSH analogues have been designed and synthesized and their biological activities determined at hMC3R, hMC4R, and hMC5R.	Histidine	63-66	proopiomelanocortin	Homo sapiens	82-91
14584947-3	2003	To probe the receptor active conformation of the pharmacophore His-Phe-Arg-Trp in gamma-MSH, two different series of gamma-MSH analogues have been designed and synthesized and their biological activities determined at hMC3R, hMC4R, and hMC5R.	Histidine	63-66	proopiomelanocortin	Homo sapiens	117-126
14725359-1	2003	PURPOSE: The aim of the study was to investigate the effect of histidine on the stability and physical properties of a fully human anti-IL8 monoclonal antibody (ABX-IL8) in aqueous and solid forms.	Histidine	63-72	C-X-C motif chemokine ligand 8	Homo sapiens	136-139
14725359-1	2003	PURPOSE: The aim of the study was to investigate the effect of histidine on the stability and physical properties of a fully human anti-IL8 monoclonal antibody (ABX-IL8) in aqueous and solid forms.	Histidine	63-72	C-X-C motif chemokine ligand 8	Homo sapiens	165-168
14725359-11	2003	CONCLUSIONS: Histidine enhanced the stability of ABX-IL8 in both aqueous and lyophilized forms.	Histidine	13-22	C-X-C motif chemokine ligand 8	Homo sapiens	53-56
14656441-2	2003	YPD1 functions as a histidine-phosphorylated protein intermediate required for phosphoryl group transfer from a membrane-bound sensor histidine kinase (SLN1) to two distinct response regulator proteins (SSK1 and SKN7).	Histidine	20-29	mitogen-activated protein kinase kinase kinase SSK1	Saccharomyces cerevisiae S288C	203-207
14656441-2	2003	YPD1 functions as a histidine-phosphorylated protein intermediate required for phosphoryl group transfer from a membrane-bound sensor histidine kinase (SLN1) to two distinct response regulator proteins (SSK1 and SKN7).	Histidine	20-29	kinase-regulated stress-responsive transcription factor SKN7	Saccharomyces cerevisiae S288C	212-216
14595027-5	2003	The mutants, His-273 and His-175 p53, adopted the active conformation, with a dramatic decrease in the fraction of denatured protein.	Histidine	25-28	tumor protein p53	Homo sapiens	33-36
14584938-5	2003	The absence of this COX-2 secondary pocket in the COX-1 binding site is due to the presence of the bulky Ile(523) in COX-1 such that access to the amino acid residues (Ile(517), Phe(518), Gln(192), and His(90)), which line the COX-2 secondary pocket with which the SO(2)Me pharmacophore could interact, is hindered.	Histidine	202-205	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	117-122
14567692-3	2003	In contrast, substitution of V266 with histidine abolished the activity of the procaspase-3 as well as that of the mature caspase.	Histidine	39-48	caspase 3	Homo sapiens	79-91
12959987-7	2003	However, l-His potentiates cAMP response element reporter activity in INS-1 cells and in human embryonic kidney-293 cells expressing either the GLP-1R alone or the CaSR and GLP-1R.	Histidine	9-14	calcium sensing receptor	Homo sapiens	164-168
12966034-3	2003	Here, we demonstrate motor neuron disease in transgenic mice expressing a SOD1 variant that mutates the four histidine residues that coordinately bind Cu.	Histidine	109-118	superoxide dismutase 1, soluble	Mus musculus	74-78
14598388-5	2003	Covalent labeling of engineered cysteines and pH titration of engineered cysteines and histidines lead to the conclusion that the CFTR anion conduction path includes a positively charged outer vestibule.	Histidine	87-97	CF transmembrane conductance regulator	Homo sapiens	130-134
14564556-0	2003	Could the tyrosine-histidine ligand to CuB in cytochrome c oxidase be coordinatively labile?	Histidine	19-28	cytochrome c, somatic	Homo sapiens	46-58
14564556-2	2003	Density functional theory calculations have been used to evaluate the effects of inter-ring interactions within a covalently linked histidine-tyrosine cofactor such as that which is a ligand to the Cu(B) centre in cytochrome c oxidases and to investigate the energetics of histidine substitution at the Cu(B) centre.	Histidine	132-141	cytochrome c, somatic	Homo sapiens	214-226
14564556-2	2003	Density functional theory calculations have been used to evaluate the effects of inter-ring interactions within a covalently linked histidine-tyrosine cofactor such as that which is a ligand to the Cu(B) centre in cytochrome c oxidases and to investigate the energetics of histidine substitution at the Cu(B) centre.	Histidine	273-282	cytochrome c, somatic	Homo sapiens	214-226
14564556-5	2003	The calculations reveal that displacement of a histidine ligand from the Cu(B) centre, as is suggested in proposals of "histidine cycle" mechanisms for proton pumping in cytochrome c oxidases, is only energetically feasible if accompanied by protonation of the histidine imidazole and coupled to an endothermic process.	Histidine	47-56	cytochrome c, somatic	Homo sapiens	170-182
14564556-5	2003	The calculations reveal that displacement of a histidine ligand from the Cu(B) centre, as is suggested in proposals of "histidine cycle" mechanisms for proton pumping in cytochrome c oxidases, is only energetically feasible if accompanied by protonation of the histidine imidazole and coupled to an endothermic process.	Histidine	120-129	cytochrome c, somatic	Homo sapiens	170-182
14617798-9	2003	It was further observed that the GIP can bind both Zn(2+) and Co(2+); the Co(2+) peptide complex was shown to have a distorted tetrahedral symmetry, involving coordination of two cysteine and two histidine residues.	Histidine	196-205	gastric inhibitory polypeptide	Homo sapiens	33-36
14575802-2	2003	Both systemic capsaicin pretreatment and intravenous administration of CGRP receptor antagonist, human CGRP-(8-37), completely abolished the protective effect of intracisternal TRH analog (RX-77368; p-Glu-His-(3,3"-dimethyl)-Pro-NH2, 5 ng) against carbon tetrachloride (CCl4)-induced acute liver injury, assessed by serum alanin aminotransferase levels and histological changes.	Histidine	205-208	calcitonin related polypeptide alpha	Homo sapiens	71-75
14642084-2	2003	METHODS: Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) were performed to genotype mEH polymorphisms in exon3 (Tyr113--&gt;His) and exon4 (His139--&gt;Arg) in 100 COPD patients and 100 age and sex matched healthy controls.	Histidine	160-163	epoxide hydrolase 1, microsomal	Mus musculus	120-123
14575802-2	2003	Both systemic capsaicin pretreatment and intravenous administration of CGRP receptor antagonist, human CGRP-(8-37), completely abolished the protective effect of intracisternal TRH analog (RX-77368; p-Glu-His-(3,3"-dimethyl)-Pro-NH2, 5 ng) against carbon tetrachloride (CCl4)-induced acute liver injury, assessed by serum alanin aminotransferase levels and histological changes.	Histidine	205-208	calcitonin related polypeptide alpha	Homo sapiens	103-107
14692513-0	2003	Binding of the human "electron transferring flavoprotein" (ETF) to the medium chain acyl-CoA dehydrogenase (MCAD) involves an arginine and histidine residue.	Histidine	139-148	acyl-CoA dehydrogenase medium chain	Homo sapiens	71-106
14692513-0	2003	Binding of the human "electron transferring flavoprotein" (ETF) to the medium chain acyl-CoA dehydrogenase (MCAD) involves an arginine and histidine residue.	Histidine	139-148	acyl-CoA dehydrogenase medium chain	Homo sapiens	108-112
14692513-4	2003	Spectral analyses of native ETF vs modified ETF suggested that flavin binding was not affected and that the loss of ETF activity with MCAD involved modification of one ETF arginine residue and one ETF histidine residue respectively.	Histidine	201-210	acyl-CoA dehydrogenase medium chain	Homo sapiens	134-138
14692513-5	2003	MCAD and octanoyl-CoA protected ETF against inactivation by both 2,3-butanedione and DEPC indicating that the arginine and histidine residues are present in or around the MCAD binding site.	Histidine	123-132	acyl-CoA dehydrogenase medium chain	Homo sapiens	0-4
14692513-5	2003	MCAD and octanoyl-CoA protected ETF against inactivation by both 2,3-butanedione and DEPC indicating that the arginine and histidine residues are present in or around the MCAD binding site.	Histidine	123-132	acyl-CoA dehydrogenase medium chain	Homo sapiens	171-175
12962490-2	2003	These histidine mutation sites are distributed through the four cooperative folding units of cytochrome c.	Histidine	6-15	cytochrome c, somatic	Homo sapiens	93-105
14515136-5	2003	A PrP(59-91) peptide lacking His residue shows as much neuroprotection as the native peptide; however, PrP(59-91) without Trp residues only partially protected against copper toxicity.	Histidine	29-32	prion protein	Homo sapiens	2-5
14515136-7	2003	We conclude that the N-terminal tandem octarepeat of the human PrP(C) protects neurons against copper toxicity by a differential contribution of the binding (His) and reducing (Trp) copper activities of PrP(59-91).	Histidine	158-161	prion protein	Homo sapiens	63-69
14515136-7	2003	We conclude that the N-terminal tandem octarepeat of the human PrP(C) protects neurons against copper toxicity by a differential contribution of the binding (His) and reducing (Trp) copper activities of PrP(59-91).	Histidine	158-161	prion protein	Homo sapiens	63-66
12794066-6	2003	Surface residues of thrombin further involved in high specificity fibrin-enhanced factor XIII activation were identified as His-66, Tyr-71, and Asn-74.	Histidine	124-127	coagulation factor II, thrombin	Homo sapiens	20-28
12944466-7	2003	The interaction involves the I-mfa domain of HIC and the regulatory histidine-rich region of cyclin T1.	Histidine	68-77	cyclin T1	Homo sapiens	93-102
14567632-8	2003	Zinc inhibited the PEPT1 function, possibly by interacting with histidine residues of PEPT1 that are part of an H+-binding site.	Histidine	64-73	solute carrier family 15 member 1	Homo sapiens	19-24
14567632-8	2003	Zinc inhibited the PEPT1 function, possibly by interacting with histidine residues of PEPT1 that are part of an H+-binding site.	Histidine	64-73	solute carrier family 15 member 1	Homo sapiens	86-91
14522910-12	2003	Similar tumors composed of GeneSwitch-3T3 cells engineered to express ps20-V5-His under mifepristone regulation showed a 129% increase in microvessel density after induction of ps20-V5-His.	Histidine	78-81	WAP four-disulfide core domain 1	Homo sapiens	70-74
14522910-12	2003	Similar tumors composed of GeneSwitch-3T3 cells engineered to express ps20-V5-His under mifepristone regulation showed a 129% increase in microvessel density after induction of ps20-V5-His.	Histidine	78-81	WAP four-disulfide core domain 1	Homo sapiens	177-181
14522910-12	2003	Similar tumors composed of GeneSwitch-3T3 cells engineered to express ps20-V5-His under mifepristone regulation showed a 129% increase in microvessel density after induction of ps20-V5-His.	Histidine	185-188	WAP four-disulfide core domain 1	Homo sapiens	70-74
14522910-12	2003	Similar tumors composed of GeneSwitch-3T3 cells engineered to express ps20-V5-His under mifepristone regulation showed a 129% increase in microvessel density after induction of ps20-V5-His.	Histidine	185-188	WAP four-disulfide core domain 1	Homo sapiens	177-181
12917459-0	2003	Histidine at position 61 and its adjacent amino acid residues are critical for the ability of SLAM (CD150) to act as a cellular receptor for measles virus.	Histidine	0-9	signaling lymphocytic activation molecule family member 1	Homo sapiens	94-98
12917459-0	2003	Histidine at position 61 and its adjacent amino acid residues are critical for the ability of SLAM (CD150) to act as a cellular receptor for measles virus.	Histidine	0-9	signaling lymphocytic activation molecule family member 1	Homo sapiens	100-105
12917459-6	2003	Among three amino acid differences (positions 60, 61 and 63) in this region, histidine 61 present in human SLAM was most significant, but combined substitutions with this residue and one or both of isoleucine 60 and valine 63 increased further the receptor activity of mouse SLAM.	Histidine	77-86	signaling lymphocytic activation molecule family member 1	Homo sapiens	107-111
12917459-8	2003	Thus, histidine 61 and its adjacent residues at positions 60 and 63 are critical for SLAM to act as a receptor for MV.	Histidine	6-15	signaling lymphocytic activation molecule family member 1	Homo sapiens	85-89
12904077-1	2003	It has been shown by extensive studies that alpha-MSH bioactivity is critically dependent on the core or central tetrapeptide sequence, His-Phe-Arg-Trp, however with poor selectivity for the human MC3R-MC5R.	Histidine	136-139	proopiomelanocortin	Homo sapiens	44-53
12866053-3	2003	The template based on the catalytic cysteine and two histidines in the KAS I and II is totally specific for this family, with no false hits.	Histidine	53-63	3-oxoacyl-ACP synthase, mitochondrial	Homo sapiens	71-83
12866053-4	2003	However, the role of the histidines in catalysis is different between KAS I/II and thiolase on the one hand and KAS III/chalcone synthase on the other.	Histidine	25-35	3-oxoacyl-ACP synthase, mitochondrial	Homo sapiens	70-91
14658402-1	2003	We report the clinical and neuropathological features of a Japanese family with familial amyotrophic lateral sclerosis (FALS), whose members have an amino acid substitution of histidine by arginine in Cu/Zn superoxide dismutase.	Histidine	176-185	superoxide dismutase 1	Homo sapiens	201-227
12945585-5	2003	L-Histidine and sodium azide had an inhibitory effect on UVA activation of p38 MAPK, pointing to a role of singlet oxygen in transduction of the UVA effect.	Histidine	0-11	mitogen-activated protein kinase 1	Homo sapiens	75-78
12874010-0	2003	Radiochemical investigations of gastrin-releasing peptide receptor-specific [(99m)Tc(X)(CO)3-Dpr-Ser-Ser-Ser-Gln-Trp-Ala-Val-Gly-His-Leu-Met-(NH2)] in PC-3, tumor-bearing, rodent models: syntheses, radiolabeling, and in vitro/in vivo studies where Dpr = 2,3-diaminopropionic acid and X = H2O or P(CH2OH)3.	Histidine	129-132	gastrin releasing peptide receptor	Homo sapiens	32-66
12798935-9	2003	Spatial motif searches on the homology models indicated potential metal binding sites involving cysteine and histidine residues outside the catalytic sites, existing only in either the X. laevis or the P. waltl GAPDH sequences.	Histidine	109-118	LOC108706049	Xenopus laevis	211-216
12766013-0	2003	The serum growth hormone (GH) response to provocative tests is dependent on type of assay in autosomal dominant isolated GH deficiency because of an ARG(183)HIS (R183H) GH-I gene mutation.	Histidine	157-160	growth hormone 1	Homo sapiens	10-24
12766013-0	2003	The serum growth hormone (GH) response to provocative tests is dependent on type of assay in autosomal dominant isolated GH deficiency because of an ARG(183)HIS (R183H) GH-I gene mutation.	Histidine	157-160	growth hormone 1	Homo sapiens	26-28
12759331-8	2003	This architecture is composed of the following elements: i) a glutamate residue acting as a proton acceptor coupled with a proton donor that interact with the steroid O3; ii) a proton donor (His or Ser) that interacts with O17; iii) a highly conserved sandwich-like structure providing steric hindrance and preventing C19 steroid from binding; and iv) several amino acid residues interacting with the C18.	Histidine	191-194	Bardet-Biedl syndrome 9	Homo sapiens	401-404
12821199-3	2003	A two-step procedure that includes heparin and immobilized metal ion affinity chromatographies (IMACs) was developed to purify His-tagged Nef (His(6)-Nef) expressed in bacteria in native condition.	Histidine	127-130	S100 calcium binding protein B	Homo sapiens	138-141
12821199-3	2003	A two-step procedure that includes heparin and immobilized metal ion affinity chromatographies (IMACs) was developed to purify His-tagged Nef (His(6)-Nef) expressed in bacteria in native condition.	Histidine	127-130	S100 calcium binding protein B	Homo sapiens	143-153
12777814-2	2003	YPD1, a histidine-containing phosphotransfer (HPt) protein, mediates the transfer of a phosphoryl group between the two response-regulator domains associated with SLN1 and SSK1, the R1 and R2 domains, respectively.	Histidine	8-17	mitogen-activated protein kinase kinase kinase SSK1	Saccharomyces cerevisiae S288C	172-176
12926277-1	2003	The synthesis of a Tentagel-supported peptide incorporating the reactive triad of serine, histidine and aspartic acid, found within serine protease enzymes, is described.	Histidine	90-99	coagulation factor II, thrombin	Homo sapiens	132-147
12802498-6	2003	RESULTS: Mutation of histidine 577 or lysine 676 to alanine led to a complete loss of GFAT enzyme activity.	Histidine	21-30	glutamine--fructose-6-phosphate transaminase 1	Homo sapiens	86-90
12748294-1	2003	The histidine triad (HIT) protein Hint has been found to associate with mammalian Cdk7, as well as to interact both physically and genetically with the budding yeast Cdk7 homologue Kin28.	Histidine	4-13	cyclin dependent kinase 7	Homo sapiens	82-86
12856592-4	2003	Western blot analysis with specific anti-histidines antibody revealed that the lysate of COS-7 cells transfected by rpcDNA3.1/Myc-His/hBD-2 had a strong band with molecular weight of about 10 Kd that was approximate to the size of chiasmic peptide.	Histidine	41-51	defensin beta 4A	Homo sapiens	134-139
12729654-4	2003	An example of a novel synthetic non-peptide molecule is given which mimics the His(6)-Pro(7)-Phe(8) part of Ang II and is based on the (S)-pyroglutamic acid.	Histidine	79-82	angiotensinogen	Homo sapiens	108-114
12558498-13	2003	We also demonstrate that a mutant form of DNase II alpha that lacks the purported active-site His(295) can still bind DNA, indicating that this histidine residue is not simply involved in DNA binding, but may have a direct role in catalysis.	Histidine	94-97	deoxyribonuclease 2, lysosomal	Homo sapiens	42-56
12558498-13	2003	We also demonstrate that a mutant form of DNase II alpha that lacks the purported active-site His(295) can still bind DNA, indicating that this histidine residue is not simply involved in DNA binding, but may have a direct role in catalysis.	Histidine	144-153	deoxyribonuclease 2, lysosomal	Homo sapiens	42-56
21432086-4	2003	It is known that a point mutation at amino acid 11 (from glutamine to histidine) of acatalasemic mouse catalase and a point mutation at amino acid 439 (from as paragine to serine) of hypocatalasemic mouse catalase are responsible for the catalase deficiency of acatalasemic and hypocatalasemic mice, respectively.	Histidine	70-79	catalase	Mus musculus	85-93
12746911-3	2003	The third exon of the B27 gene was analyzed for the presence of Asp(116) or His(116), which differentiates B*2709 from the other two B27 subtypes (B*2705 and B*2702) that are mostly found in Sardinia.	Histidine	76-79	melanocortin 2 receptor accessory protein	Homo sapiens	22-25
12611975-7	2003	CMi(His+) units were most responsive to histamine and to PGE(2) and less to serotonin, ACh, bradykinin, and capsaicin.	Histidine	4-7	kininogen 1	Homo sapiens	92-102
12727968-7	2003	Automatic sequencing showed two different activating mutations at codon Arg(201) of GNAS1, a substitution by histidine in two cases and by serine in one case.	Histidine	109-118	GNAS complex locus	Homo sapiens	84-89
12578831-4	2003	Replacement of His-334 in alpha(1)-antitrypsin by a serine or alanine at pH 7.4 results in the same polymerization and loop-peptide acceptance observed with antithrombin at low pH.	Histidine	15-18	serpin family A member 1	Homo sapiens	26-46
12802925-2	2003	The cell line, designated TMBL-1, carried a His-175 mutant p53.	Histidine	44-47	tumor protein p53	Homo sapiens	59-62
12717018-0	2003	Role of histidine interruption in mitigating the pathological effects of long polyglutamine stretches in SCA1: A molecular approach.	Histidine	8-17	ataxin 1	Homo sapiens	105-109
12717018-3	2003	In one such disorder, spinocerebellar ataxia (SCA1), it has been reported that certain individuals with expanded polyglutamine repeats in the disease range (Q(12)HQHQ(12)HQHQ(14/15)) but with histidine interruptions were found to be phenotypically normal.	Histidine	192-201	ataxin 1	Homo sapiens	46-50
12717018-7	2003	The study strengthens our earlier hypothesis of the importance of histidine interruptions in mitigating the pathogenicity of expanded polyglutamine tract at the SCA1 locus.	Histidine	66-75	ataxin 1	Homo sapiens	161-165
12702176-9	2003	l-Histidine added to plasma before MB plus red light treatment normalized the thrombin-induced coagulation time in a dose-dependent way.	Histidine	0-11	coagulation factor II, thrombin	Homo sapiens	78-86
12670425-6	2003	Moreover, we identify a C-terminal histidine residue, immediately proximal to the plasma membrane, mutation of which renders M channels less sensitive to PIP(2) and more sensitive to receptor-mediated inhibition.	Histidine	35-44	prolactin induced protein	Homo sapiens	154-157
12650758-1	2003	The recombinant major grass pollen allergen Phl p 6 has been expressed with a N-terminal 6 x His-tag sequence and subsequently purified using nickel-chelating Sepharose.	Histidine	93-96	S100 calcium binding protein A12	Homo sapiens	48-51
12646702-0	2003	The protein-folding speed limit: intrachain diffusion times set by electron-transfer rates in denatured Ru(NH3)5(His-33)-Zn-cytochrome c.	Histidine	113-116	cytochrome c, somatic	Homo sapiens	124-136
12686130-3	2003	Histidine and phenylalanine ammonia-lyases (HAL and PAL) possess a catalytically essential electrophilic group which has been believed to be dehydroalanine for 30 years.	Histidine	0-9	leucine rich repeat, Ig-like and transmembrane domains 1	Homo sapiens	52-55
12682337-1	2003	We have identified a heteroplasmic G to A mutation at position 12,183 of the mitochondrial transfer RNA Histidine (tRNA(His)) gene in three related patients.	Histidine	104-113	mitochondrially encoded tRNA glycine	Homo sapiens	115-124
12496262-6	2003	Human FGF-2 has three histidine residues, one falling within the region 48-58.	Histidine	22-31	fibroblast growth factor 2	Homo sapiens	6-11
12496262-7	2003	Chemical modification of histidine residues blocked FGF-2 activity and FREG-(48-58) inhibitory effect in vitro, indicating that histidine residues, in particular the one within FREG-(48-58) region, play a crucial role in the observed activity.	Histidine	25-34	fibroblast growth factor 2	Homo sapiens	52-57
12496262-7	2003	Chemical modification of histidine residues blocked FGF-2 activity and FREG-(48-58) inhibitory effect in vitro, indicating that histidine residues, in particular the one within FREG-(48-58) region, play a crucial role in the observed activity.	Histidine	128-137	fibroblast growth factor 2	Homo sapiens	52-57
12619037-1	2003	Alterations of the fragile histidine triad (Fhit) gene were investigated in rat hepatocarcinogenesis induced by a choline-deficient L-amino acid-defined (CDAA) diet.	Histidine	27-36	fragile histidine triad diadenosine triphosphatase	Rattus norvegicus	44-48
12609879-2	2003	A snake-venom PLA(2) was completely inhibited by covalent modification of the catalytic histidine 48 by p-bromophenacyl bromide.	Histidine	88-97	phospholipase A2 group IB	Homo sapiens	14-20
12588988-7	2003	Granulin bound to the histidine-rich domain of cyclin T1, which was recently found to bind to the CTD, but not to cyclin T2.	Histidine	22-31	granulin precursor	Homo sapiens	0-8
12588988-7	2003	Granulin bound to the histidine-rich domain of cyclin T1, which was recently found to bind to the CTD, but not to cyclin T2.	Histidine	22-31	cyclin T1	Homo sapiens	47-56
12590607-4	2003	However, for the AcH54 and AcH54I52 variants the fluorescence intensity drops significantly between pH 4 and 6, consistent with His 54 binding to the heme of cytochrome c.	Histidine	128-131	cytochrome c, somatic	Homo sapiens	158-170
12493732-5	2003	To gain mechanistic insight, we measured the effects of Saccharomyces cerevisiae Ssa1p (Hsp70) and Ydj1p (Hsp40) on the translocation of histidine-tagged prepro-alpha-factor (ppalphaF6H) into microsomes.	Histidine	137-146	type I HSP40 co-chaperone YDJ1	Saccharomyces cerevisiae S288C	99-104
12493732-5	2003	To gain mechanistic insight, we measured the effects of Saccharomyces cerevisiae Ssa1p (Hsp70) and Ydj1p (Hsp40) on the translocation of histidine-tagged prepro-alpha-factor (ppalphaF6H) into microsomes.	Histidine	137-146	type I HSP40 co-chaperone YDJ1	Saccharomyces cerevisiae S288C	106-111
12590613-6	2003	Nardilysin also cleaves calcitonin at His-Arg and somatostatin-14 at Cys-Lys.	Histidine	38-41	nardilysin convertase	Homo sapiens	0-10
12590607-9	2003	Thus, at physiological pH, histidine ligands provide the primary constraint on the denatured state of cytochrome c.	Histidine	27-36	cytochrome c, somatic	Homo sapiens	102-114
12566539-8	2003	Protonation of a naturally occurring histidine in the same outer vestibule location in the Kv1.5 potassium channel produced similar effects on K(+) permeation properties.	Histidine	37-46	potassium voltage-gated channel subfamily A member 5	Homo sapiens	91-96
12540540-2	2003	The egg yolk phospholipid hydrolysis activity of the His-tag Csp was about one-third of that of His-tag Cpa, but the hemolytic activity was less than 1% of that of His-tag Cpa.	Histidine	53-56	DnaJ heat shock protein family (Hsp40) member C5	Mus musculus	61-64
12540540-2	2003	The egg yolk phospholipid hydrolysis activity of the His-tag Csp was about one-third of that of His-tag Cpa, but the hemolytic activity was less than 1% of that of His-tag Cpa.	Histidine	96-99	DnaJ heat shock protein family (Hsp40) member C5	Mus musculus	61-64
12573244-0	2003	Familial hypofibrinogenaemia associated with heterozygous substitution of a conserved arginine residue; Bbeta255 Arg-->His (Fibrinogen Merivale).	Histidine	119-122	fibrinogen beta chain	Homo sapiens	124-134
12573244-2	2003	Family studies showed the mutations Bbeta255 Arg-->His (Fibrinogen Merivale) and Bbeta148 Lys-->Asn (Fibrinogen Merivale II) were on different alleles and that only the Bbeta255 Arg-->His mutation segregated with hypofibrinogenaemia.	Histidine	51-54	fibrinogen beta chain	Homo sapiens	56-66
12426310-6	2003	Mutational studies revealed that Gly(122) and His(123) are crucial for binding to SUFU, suggesting the importance of hydrophobicity for the correct binding conformation.	Histidine	46-49	SUFU negative regulator of hedgehog signaling	Homo sapiens	82-86
12568815-5	2003	When comparing with human Hb alpha-chain, alterations in important regions can be noted: alpha110 Ala-Gly, alpha114 Pro-Gly, alpha117 Phe-Tyr and alpha122 His-Gln.	Histidine	155-158	Fc gamma receptor and transporter	Homo sapiens	29-40
22062184-3	2003	Western blot analyses confirmed the covalent modification of myoglobin (Mb) histidine residues by 4-HNE.	Histidine	76-85	myoglobin	Equus caballus	61-70
18365046-1	2003	His-Val-His and His-Val-Gly-Asp are two naturally occurring peptide sequences, present at the active site of Cu,Zn-superoxide dismutase (Cu,Zn-SOD).	Histidine	0-3	superoxide dismutase 1	Homo sapiens	109-135
12674500-2	2003	N-terminally His-tagged Usp was overexpressed in E. coli cells as a non-truncated protein and purified to homogeneity in two chromatographic steps.	Histidine	13-16	ultraspiracle	Drosophila melanogaster	24-27
12706644-1	2003	INTRODUCTION: The exchange of Aalpha 16, Arg for Cys or His is the most common molecular defect in dysfibrinogenemia directly affecting the thrombin cleavage site involved in fibrinopeptide A (FPA) release.	Histidine	56-59	coagulation factor II, thrombin	Homo sapiens	140-148
12517962-3	2003	The tapasin dependence of HLA class I alleles bearing different residues at position 114 decreases in the order of acidity, with high tapasin dependence for acidic amino acids (aspartic acid and glutamic acid), moderate dependence for neutral amino acids (asparagine and glutamine), and low dependence for basic amino acids (histidine and arginine).	Histidine	325-334	TAP binding protein	Homo sapiens	4-11
18365046-0	2003	Interaction of Cu(II)with His-Val-Gly-Asp and of Zn(II) with His-Val-His, two peptides at the active site of Cu,Zn-superoxide dismutase.	Histidine	26-29	superoxide dismutase 1	Homo sapiens	109-135
18365046-1	2003	His-Val-His and His-Val-Gly-Asp are two naturally occurring peptide sequences, present at the active site of Cu,Zn-superoxide dismutase (Cu,Zn-SOD).	Histidine	0-3	superoxide dismutase 1	Homo sapiens	137-146
18365046-0	2003	Interaction of Cu(II)with His-Val-Gly-Asp and of Zn(II) with His-Val-His, two peptides at the active site of Cu,Zn-superoxide dismutase.	Histidine	61-64	superoxide dismutase 1	Homo sapiens	109-135
18365046-0	2003	Interaction of Cu(II)with His-Val-Gly-Asp and of Zn(II) with His-Val-His, two peptides at the active site of Cu,Zn-superoxide dismutase.	Histidine	61-64	superoxide dismutase 1	Homo sapiens	109-135
12572700-13	2003	The balance of bax-bcl2 is important in the control of apoptosis as well as loss of fragile histidine triad expression.	Histidine	92-101	BCL2 associated X, apoptosis regulator	Homo sapiens	15-18
12572700-13	2003	The balance of bax-bcl2 is important in the control of apoptosis as well as loss of fragile histidine triad expression.	Histidine	92-101	BCL2 apoptosis regulator	Homo sapiens	19-23
12518222-1	2003	The DNA fragment encoding N-terminal region of human c-Src was amplified from Caco-2 cell total RNA by RT-PCR and cloned into vector pMFHT to obtain His-tag fusion expression plasmid pMF-SrcHT, which was based on T7 expression system.	Histidine	149-152	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	53-58
12509999-3	2003	We cloned the gene of rat mevalonate kinase into a bacterial expression vector pLM1 with six continuous histidine codons attached to the 5(") of the gene.	Histidine	104-113	mevalonate kinase	Rattus norvegicus	26-43
12587790-3	2003	However, Ad-Apo2L/TRAIL is a poor inducer of cell death, even in the presence of inhibitors of protein synthesis, in human glioma cell lines which are sensitive to soluble recombinant human His-tagged Apo2L/TRAIL (amino acids 114-281).	Histidine	190-193	TNF superfamily member 10	Homo sapiens	12-17
12587790-3	2003	However, Ad-Apo2L/TRAIL is a poor inducer of cell death, even in the presence of inhibitors of protein synthesis, in human glioma cell lines which are sensitive to soluble recombinant human His-tagged Apo2L/TRAIL (amino acids 114-281).	Histidine	190-193	TNF superfamily member 10	Homo sapiens	18-23
12587790-3	2003	However, Ad-Apo2L/TRAIL is a poor inducer of cell death, even in the presence of inhibitors of protein synthesis, in human glioma cell lines which are sensitive to soluble recombinant human His-tagged Apo2L/TRAIL (amino acids 114-281).	Histidine	190-193	TNF superfamily member 10	Homo sapiens	201-206
12587790-4	2003	Moreover, Ad-Apo2L/TRAIL gene transfer inhibits soluble His-tagged Apo2L/TRAIL-induced apoptosis, strongly suggesting that the adenovirally encoded full-length Apo2L/TRAIL is not a suitable molecule for glioma cancer gene therapy.	Histidine	56-59	TNF superfamily member 10	Homo sapiens	13-18
12587790-4	2003	Moreover, Ad-Apo2L/TRAIL gene transfer inhibits soluble His-tagged Apo2L/TRAIL-induced apoptosis, strongly suggesting that the adenovirally encoded full-length Apo2L/TRAIL is not a suitable molecule for glioma cancer gene therapy.	Histidine	56-59	TNF superfamily member 10	Homo sapiens	19-24
12587790-4	2003	Moreover, Ad-Apo2L/TRAIL gene transfer inhibits soluble His-tagged Apo2L/TRAIL-induced apoptosis, strongly suggesting that the adenovirally encoded full-length Apo2L/TRAIL is not a suitable molecule for glioma cancer gene therapy.	Histidine	56-59	TNF superfamily member 10	Homo sapiens	67-72
12587790-4	2003	Moreover, Ad-Apo2L/TRAIL gene transfer inhibits soluble His-tagged Apo2L/TRAIL-induced apoptosis, strongly suggesting that the adenovirally encoded full-length Apo2L/TRAIL is not a suitable molecule for glioma cancer gene therapy.	Histidine	56-59	TNF superfamily member 10	Homo sapiens	73-78
12587790-4	2003	Moreover, Ad-Apo2L/TRAIL gene transfer inhibits soluble His-tagged Apo2L/TRAIL-induced apoptosis, strongly suggesting that the adenovirally encoded full-length Apo2L/TRAIL is not a suitable molecule for glioma cancer gene therapy.	Histidine	56-59	TNF superfamily member 10	Homo sapiens	67-72
12587790-4	2003	Moreover, Ad-Apo2L/TRAIL gene transfer inhibits soluble His-tagged Apo2L/TRAIL-induced apoptosis, strongly suggesting that the adenovirally encoded full-length Apo2L/TRAIL is not a suitable molecule for glioma cancer gene therapy.	Histidine	56-59	TNF superfamily member 10	Homo sapiens	73-78
12463753-2	2002	We have probed the three-dimensional structure of the lumenal region of human tapasin (residues 1-392) tagged with a (His)(6) sequence at its C-terminus using biochemical and biophysical techniques.	Histidine	118-121	TAP binding protein	Homo sapiens	78-85
12589073-6	2002	The Arabidopsis CRE1 histidine kinase and its related proteins AHK2 and AHK3 perceive cytokinins in the environment and transduce a signal, presumably through the AHP bridge components that carry the histidine-containing phosphotransfer (HPt) domain, to the ARR1 response regulator that transcriptionally activates genes immediately responsive to cytokinins.	Histidine	21-30	histidine kinase 3	Arabidopsis thaliana	72-76
12372819-6	2002	Using N-terminal sequencing they were identified as the normal cleavage site Arg(494)-Val(495) and the novel site Arg(424)-His(425) located in the K4 domain of the alpha-chain.	Histidine	123-126	Fc gamma receptor and transporter	Homo sapiens	164-175
12356748-5	2002	Oxidation of select histidine residues that bind metals in the active site mediates SOD1 aggregation.	Histidine	20-29	superoxide dismutase 1	Homo sapiens	84-88
12499401-0	2002	Histidine 271 has a functional role in pig alpha-1,3galactosyltransferase enzyme activity.	Histidine	0-9	N-acetyllactosaminide alpha-1,3-galactosyltransferase	Sus scrofa	43-73
12512607-18	2002	Histidine appeared to be the first limiting AA for milk protein synthesis on the control diet.	Histidine	0-9	Weaning weight-maternal milk	Bos taurus	51-55
12202495-1	2002	This report describes the identification of a novel protein named PS1D (Genbank accession number ), which is composed of an S1-like RNA-binding domain, a (cysteine)x3-(histidine) CCCH-zinc finger, and a very basic carboxyl domain.	Histidine	168-177	zinc finger CCHC-type containing 17	Homo sapiens	66-70
12324470-7	2002	Among these sequences, Gln(199)-Ala(203), Leu(225)-Leu(230), and Gly(305)-His(309) are important for the binding of both ligands, whereas Arg(144)-Lys(148) is more critical for fibrinogen than for C3bi binding.	Histidine	74-77	fibrinogen beta chain	Homo sapiens	177-187
12406085-6	2002	Interestingly, the non-rearranged allele of ETV6 in the MT-ALL cell line carries an arginine to histidine (R399H) mutation which affects a conserved amino acid in the ets DNA binding domain.	Histidine	96-105	ETS variant transcription factor 6	Homo sapiens	44-48
12186871-3	2002	We replaced three charged amino acids, Lys(332), His(335), and Asp(336), predicted to be in the sixth transmembrane (TM6) helix of MRP1 with neutral and oppositely charged amino acids and determined the effect on substrate specificity and transport activity.	Histidine	49-52	ATP binding cassette subfamily C member 1	Homo sapiens	131-135
19003116-0	2002	Possible involvement of phospholipase A(2) and cyclooxygenase in stimulatory action of L-histidine on protein synthesis in L6 myotubes.	Histidine	87-98	phospholipase A2 group IB	Homo sapiens	24-61
19003116-4	2002	These results suggest an involvement of phospholipase A(2) and cyclooxygenase in the stimulatory action of L-histidine on protein synthesis in L6 myotubes.	Histidine	107-118	phospholipase A2 group IB	Homo sapiens	40-77
12186871-7	2002	Substitutions of MRP1-His(335) also selectively diminished LTC(4) transport and photolabeling but to a lesser extent.	Histidine	22-25	ATP binding cassette subfamily C member 1	Homo sapiens	17-21
12106015-7	2002	Experiments with engineered perMFE-1 variants demonstrate that the H1/I competence of domain A requires stabilizing interactions with domains D and E. The variant His-perMFE (residues 288-479)Delta, in which the domain C is deleted, is stable and has hydratase-1 activity.	Histidine	163-166	enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase	Rattus norvegicus	28-36
12183636-3	2002	The Rpn11 subunit of the proteasome lid subcomplex contains a highly conserved Jab1/MPN domain-associated metalloisopeptidase (JAMM) motif-EX(n)HXHX(10)D. Mutation of the predicted active-site histidines to alanine (rpn11AXA) was lethal and stabilized ubiquitin pathway substrates in yeast.	Histidine	193-203	proteasome regulatory particle lid subunit RPN11	Saccharomyces cerevisiae S288C	4-9
12395946-8	2002	This effect was particularly dramatic for the positively charged side-chains Arg, Lys and His, whose significant enhancement of hydrophobicity in the presence of the cyano column contrasted with their increase in hydrophilicity in the presence of the considerably more hydrophobic C18 stationary phase.	Histidine	90-93	Bardet-Biedl syndrome 9	Homo sapiens	281-284
12084014-5	2002	Characterization of the cDNA sequence of rabbit factor XI and its amino acid translation revealed that in the rabbit protein a His residue replaces the Cys-321 that forms the interchain disulphide linkage in human factor XI, explaining why rabbit factor XI is a monomer in non-reducing SDS/PAGE.	Histidine	127-130	coagulation factor XI	Oryctolagus cuniculus	48-57
12084014-5	2002	Characterization of the cDNA sequence of rabbit factor XI and its amino acid translation revealed that in the rabbit protein a His residue replaces the Cys-321 that forms the interchain disulphide linkage in human factor XI, explaining why rabbit factor XI is a monomer in non-reducing SDS/PAGE.	Histidine	127-130	coagulation factor XI	Oryctolagus cuniculus	214-223
12084014-5	2002	Characterization of the cDNA sequence of rabbit factor XI and its amino acid translation revealed that in the rabbit protein a His residue replaces the Cys-321 that forms the interchain disulphide linkage in human factor XI, explaining why rabbit factor XI is a monomer in non-reducing SDS/PAGE.	Histidine	127-130	coagulation factor XI	Oryctolagus cuniculus	214-223
12215525-9	2002	Histidine limitation in the presence of histidinol induced a twofold increase in the phosphorylation of eIF2alpha and a concomitant reduction in eIF2B activity in perfused livers from wild-type mice, but no changes in livers from Gcn2(-/-) mice.	Histidine	0-9	eukaryotic translation initiation factor 2B, subunit 4 delta	Mus musculus	145-150
12215525-9	2002	Histidine limitation in the presence of histidinol induced a twofold increase in the phosphorylation of eIF2alpha and a concomitant reduction in eIF2B activity in perfused livers from wild-type mice, but no changes in livers from Gcn2(-/-) mice.	Histidine	0-9	eukaryotic translation initiation factor 2 alpha kinase 4	Mus musculus	230-234
12204541-5	2002	As for cadmium"s inhibitory mechanism on catalase activity, our data, obtained in the pH range 6.0-8.0, are a preliminary indication that the negative effect of this metal is probably due to imidazole residue binding of His-74 which is essential in the decomposition of hydrogen peroxide.	Histidine	220-223	catalase	Rattus norvegicus	41-49
12441142-5	2002	In this study we describe abrogation of IL-7 driven proliferation and attenuated phosphotyrosine signaling by IL-7(143) (Trp-Ala) and IL-7(143) (Trp-His) in IL-7R expressing T and B leukemia cells.	Histidine	149-152	interleukin 7	Homo sapiens	40-44
12371203-5	2002	Sonochemical generation of active oxygen species in the presence of EB, measured by ESR spectroscopy, was also inhibited by histidine.	Histidine	124-133	esterase 5 regulator	Mus musculus	84-87
12105206-7	2002	Site-directed mutagenesis of the EGFR L2 domain showed that a cluster of residues, His(394)-Ile(402), was essential for both decorin and EGF binding.	Histidine	83-86	epidermal growth factor receptor	Homo sapiens	33-37
12217691-12	2002	A hybrid dimer of FliH and His-FliHDelta1 (lacking the first ten amino acid residues) retained the ability to form a complex with His-FliI.	Histidine	27-30	FLII actin remodeling protein	Homo sapiens	134-138
12237104-7	2002	A WAVE1 VCA fragment tagged with six histidines (His) showed markedly reduced activity compared to GST-fused VCA, whereas His-tagged N-WASP VCA showed similar activity to GST-fused VCA.	Histidine	37-47	WASP family member 1	Homo sapiens	2-7
12237104-7	2002	A WAVE1 VCA fragment tagged with six histidines (His) showed markedly reduced activity compared to GST-fused VCA, whereas His-tagged N-WASP VCA showed similar activity to GST-fused VCA.	Histidine	49-52	WASP family member 1	Homo sapiens	2-7
12110691-2	2002	The transcriptional activator protein Bas2 is required to express more than 20 genes in pathways for purine nucleotide and histidine biosynthesis, phosphate utilization, and the HO endonuclease by acting with co-regulator proteins Bas1, Pho4, and Swi5.	Histidine	123-132	SWI5 homologous recombination repair protein	Homo sapiens	247-251
12110675-2	2002	In FOG proteins, the interacting domains are also ZnFs; these domains are related to classical CCHH fingers but have an His --&gt; Cys substitution at the final zinc-ligating position.	Histidine	120-123	zinc finger protein, FOG family member 1	Homo sapiens	3-6
12224952-8	2002	The most potent compound 1n with the pharmacophore motif "His-DPhe-Arg-Trp" was identified as having an EC(50) value of 165 nM at mMC1R, 7600 nM at mMC3R, 650 nM at mMC4R, and 335 nM at mMC5R.	Histidine	58-61	melanocortin 1 receptor	Mus musculus	130-135
12217691-12	2002	A hybrid dimer of FliH and His-FliHDelta1 (lacking the first ten amino acid residues) retained the ability to form a complex with His-FliI.	Histidine	130-133	FLII actin remodeling protein	Homo sapiens	134-138
12213223-6	2002	PDT-induced cytochrome c release from mitochondria into the cytosol was inhibited by L-histidine, but not by ISP-1.	Histidine	85-96	cytochrome c, somatic	Homo sapiens	12-24
12207908-6	2002	It was suggested that the polymerization of Fas antigen, which was the essential process for the efficient induction of apoptosis, was interfered by the alteration of CRD1, and that this portion, named the "histidine-rich region," played a critical role in Fas assembly.	Histidine	207-216	CORD1	Homo sapiens	167-171
12006088-5	2002	Recombinantly produced bHRP-4 and murine HDGF (mHDGF) histidine-tagged polypeptides display growth-factor activity for cultured primary human fibroblasts at an optimum concentration of 1 ng/ml in serum-free medium.	Histidine	54-63	heparin binding growth factor	Mus musculus	41-45
12198172-5	2002	Sequence alignments of DcpS from different organisms revealed the presence of a conserved hexapeptide, containing a histidine triad (HIT) sequence with three histidines separated by hydrophobic residues.	Histidine	116-125	decapping enzyme, scavenger	Homo sapiens	23-27
12198172-5	2002	Sequence alignments of DcpS from different organisms revealed the presence of a conserved hexapeptide, containing a histidine triad (HIT) sequence with three histidines separated by hydrophobic residues.	Histidine	158-168	decapping enzyme, scavenger	Homo sapiens	23-27
12198172-6	2002	Mutagenesis analysis revealed that the central histidine within the DcpS HIT motif is critical for decapping activity and defines the HIT motif as a new mRNA decapping domain, making DcpS the first member of the HIT family of proteins with a defined biological function.	Histidine	47-56	decapping enzyme, scavenger	Homo sapiens	68-72
12198172-6	2002	Mutagenesis analysis revealed that the central histidine within the DcpS HIT motif is critical for decapping activity and defines the HIT motif as a new mRNA decapping domain, making DcpS the first member of the HIT family of proteins with a defined biological function.	Histidine	47-56	decapping enzyme, scavenger	Homo sapiens	183-187
12234472-2	2002	We have developed two methods for detecting polymorphisms at exons 3 (Tyr113--&gt;His) and 4 (His139--&gt;Arg) of the mEH gene based on different melting temperatures (T(m)) of fluorescent-labeled oligonucleotide hybridization probes using single-step assays that combine fluorescence PCR and melting curve analysis (LightCycler methodology).	Histidine	82-85	epoxide hydrolase 1, microsomal	Mus musculus	118-121
12077146-6	2002	On the other hand, cells expressing all single, double, or triple histidine-substituted CXCR1 demonstrated high affinity binding to interleukin 8 in the presence and absence of metal ions.	Histidine	66-75	C-X-C motif chemokine ligand 8	Homo sapiens	132-145
12322785-3	2002	The purpose of this report is to determine if the administration of a specific caspase-9 inhibitor, Z-Leu-Glu(Ome)-His-Asp(Ome)-FMK x TFA (Z-LEHD-FMK) would attenuate apoptosis and the resultant brain injury after ischemia.	Histidine	115-118	caspase 9	Rattus norvegicus	79-88
12065592-5	2002	The different binding mode of estradiol is associated with a difference in the position/orientation of residues (Leu(131) and Lys(134)) in the loop segment (Leu(131)-His(136)) that covers the steroid-binding site as well as others (Leu(171)-Lys(173) and Trp(84)) on the surface of human SHBG and may provide a basis for ligand-dependent interactions between SHBG and other macromolecules.	Histidine	166-169	sex hormone binding globulin	Homo sapiens	287-291
12065592-5	2002	The different binding mode of estradiol is associated with a difference in the position/orientation of residues (Leu(131) and Lys(134)) in the loop segment (Leu(131)-His(136)) that covers the steroid-binding site as well as others (Leu(171)-Lys(173) and Trp(84)) on the surface of human SHBG and may provide a basis for ligand-dependent interactions between SHBG and other macromolecules.	Histidine	166-169	sex hormone binding globulin	Homo sapiens	358-362
12167017-4	2002	The optical absorption spectra of the Co(II) complexes of Ant-F and its derivative proteins suggest that the geometry of the metal center of holo-Ant-F is tetrahedral and that the mutated Cys(2)His(2) residues are involved in the complex formation.	Histidine	194-197	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-44
12200603-8	2002	RESULTS: A G:C to A:T mutation at codon 175 of p53 resulting in an arginine --&gt; histidine substitution was detected, confirming the clinical diagnosis of LFS.	Histidine	83-92	tumor protein p53	Homo sapiens	47-50
12177781-4	2002	In addition, we examined whether the Fragile histidine triad and mismatch repair protein expression correlated with p53 expression and clinicopathological findings.	Histidine	45-54	tumor protein p53	Homo sapiens	116-119
12180976-5	2002	Purified recombinant S64/SBP2 protein, expressed as a histidine-tagged protein in Escherichia coli, exhibited nucleotide-binding specificity to guanine nucleotides.	Histidine	54-63	sucrose-binding protein 2	Glycine max	25-29
12146983-3	2002	Here, we investigate topological effects on loop formation probabilities in denatured iso-1-cytochrome c by comparing histidine-heme binding affinities for histidines on the N- versus the C-terminal side of the heme.	Histidine	118-127	cytochrome c, somatic	Homo sapiens	92-104
12146983-3	2002	Here, we investigate topological effects on loop formation probabilities in denatured iso-1-cytochrome c by comparing histidine-heme binding affinities for histidines on the N- versus the C-terminal side of the heme.	Histidine	156-166	cytochrome c, somatic	Homo sapiens	92-104
12115546-4	2002	At position 874, only the histidine to tyrosine substitution could broaden AR ligand specificity.	Histidine	26-35	androgen receptor	Homo sapiens	75-77
12135367-0	2002	Differential effect of a his tag at the N- and C-termini: functional studies with recombinant human serum transferrin.	Histidine	25-28	transferrin	Homo sapiens	106-117
12127151-2	2002	To test the hypothesis that the toxicity of mutant SOD1 originates in Cu(2+)-mediated formation of toxic radicals, we generated transgenic mice that express human SOD1 that encodes disease-linked mutations at two of the four histidine residues that are crucial for the coordinated binding of copper (H46R/H48Q).	Histidine	225-234	superoxide dismutase 1, soluble	Mus musculus	51-55
11955285-5	2002	We therefore expressed the N-terminal 581 amino acids of IP3R1 as a His-tagged recombinant protein, containing the functional IP3-binding pocket.	Histidine	68-71	inositol 1,4,5-trisphosphate receptor type 1	Homo sapiens	57-62
12374458-1	2002	McCune-Albright syndrome (MAS) is caused by embryonic somatic mutations leading to the substitution of His or Cys for Arg at amino acid 201 of the alpha-subunit of the signal transduction protein Gs (Gsalpha).	Histidine	103-106	GNAS complex locus	Homo sapiens	200-207
12374458-5	2002	In addition, a heterozygous mutation encoding substitution of Arg201 of Gsalpha with His was found.	Histidine	85-88	GNAS complex locus	Homo sapiens	72-79
12081473-0	2002	The aromatic "trapping" of the catalytic histidine is essential for efficient catalysis in acetylcholinesterase.	Histidine	41-50	acetylcholinesterase (Cartwright blood group)	Homo sapiens	91-111
12127151-2	2002	To test the hypothesis that the toxicity of mutant SOD1 originates in Cu(2+)-mediated formation of toxic radicals, we generated transgenic mice that express human SOD1 that encodes disease-linked mutations at two of the four histidine residues that are crucial for the coordinated binding of copper (H46R/H48Q).	Histidine	225-234	superoxide dismutase 1	Homo sapiens	163-167
12069588-0	2002	Differential interactions of estrogens and antiestrogens at the 17 beta-hydroxyl or counterpart hydroxyl with histidine 524 of the human estrogen receptor alpha.	Histidine	110-119	estrogen receptor 1	Homo sapiens	137-160
12408757-2	2002	METHODS: VIP(28) was modified at the carboxyl terminal by the addition of His-tag which was the chelating site of (99m)Tc(I) and the general purification tag for immobilized metal ion affinity chromatography.	Histidine	74-77	vasoactive intestinal polypeptide	Mus musculus	9-12
12036910-5	2002	The facile reaction of this cysteine residue with NO is attributable to its interaction with other residues in hAGT including His-146 and Glu-172 that activate the sulfhydryl group of Cys-145 to allow its nucleophilic attack on DNA adducts.	Histidine	126-129	angiotensinogen	Homo sapiens	111-115
11937510-5	2002	Substitutions of the Mg and Zn1 neighboring residues His-317 and His-153 increased k(cat) and increased K(m) when compared with wild-type PLAP, contrary to what was predicted by the reciprocal substitutions in ECAP.	Histidine	53-56	alkaline phosphatase, placental	Homo sapiens	138-142
11937510-5	2002	Substitutions of the Mg and Zn1 neighboring residues His-317 and His-153 increased k(cat) and increased K(m) when compared with wild-type PLAP, contrary to what was predicted by the reciprocal substitutions in ECAP.	Histidine	65-68	alkaline phosphatase, placental	Homo sapiens	138-142
11979549-3	2002	At FRA3B, the fragile histidine triad (FHIT) gene spans more than 1 Mb, and at FRA16D, the WWOX gene spans more than 750 kb.	Histidine	22-31	fragile histidine triad gene	Mus musculus	39-43
12067249-10	2002	LC/MS/MS analyses of trypsin digests of HSA incubations with either 4-hydroxy-5-phenyl-[1,3]oxazinan-2-one or 2-phenylpropenal identified HSA-2-phenylpropenal adducts formed specifically at residues His-242 and His-247.	Histidine	199-202	albumin	Homo sapiens	40-43
12067249-10	2002	LC/MS/MS analyses of trypsin digests of HSA incubations with either 4-hydroxy-5-phenyl-[1,3]oxazinan-2-one or 2-phenylpropenal identified HSA-2-phenylpropenal adducts formed specifically at residues His-242 and His-247.	Histidine	199-202	albumin	Homo sapiens	138-141
12067249-10	2002	LC/MS/MS analyses of trypsin digests of HSA incubations with either 4-hydroxy-5-phenyl-[1,3]oxazinan-2-one or 2-phenylpropenal identified HSA-2-phenylpropenal adducts formed specifically at residues His-242 and His-247.	Histidine	211-214	albumin	Homo sapiens	40-43
12067249-10	2002	LC/MS/MS analyses of trypsin digests of HSA incubations with either 4-hydroxy-5-phenyl-[1,3]oxazinan-2-one or 2-phenylpropenal identified HSA-2-phenylpropenal adducts formed specifically at residues His-242 and His-247.	Histidine	211-214	albumin	Homo sapiens	138-141
12039800-9	2002	Dye-coupling experiments showed that HeLa-Cx43(His)(6) cells readily passed Lucifer yellow and N-(2-aminoethyl)biotinamide hydrochloride (neurobiotin); in contrast, HeLa-Cx45 and HeLa-Cx43(His)(6)/Cx45 cells showed extensive intercellular passage of neurobiotin but little coupling with Lucifer yellow.	Histidine	47-50	gap junction protein gamma 1	Homo sapiens	170-174
12039800-6	2002	Connexons were solubilized from HeLa-Cx43(His)(6)/Cx45 cells by using Triton X-100 and were applied to a Ni(2+)-NTA column, which binds the His(6) sequence.	Histidine	140-143	gap junction protein gamma 1	Homo sapiens	50-54
12236546-2	2002	One of them, pKa value of acidic transition, was shifted from an apparent pKa value 2.5 (typical for cyt c in low ionic strength solvent) to approximately 5.20 +/- 0.15 upon polyanion binding to the protein, pointing to a likely involvement of histidines 26 and/or 33 in the protein acidic transition in complex with the polyanion.	Histidine	244-254	cytochrome c, somatic	Homo sapiens	101-106
11912212-3	2002	The PIMT binding sites on CBP and p300 are located in the cysteine-histidine-rich C/H1 and C/H3 domains, and the PIMT binding site on PBP is in the region encompassing amino acids 1101-1560.	Histidine	67-76	CREB binding protein	Homo sapiens	26-29
12039800-7	2002	Cx45 was coeluted from the column with Cx43(His)(6), demonstrating that some hemichannels contain both connexins.	Histidine	44-47	gap junction protein gamma 1	Homo sapiens	0-4
12039800-9	2002	Dye-coupling experiments showed that HeLa-Cx43(His)(6) cells readily passed Lucifer yellow and N-(2-aminoethyl)biotinamide hydrochloride (neurobiotin); in contrast, HeLa-Cx45 and HeLa-Cx43(His)(6)/Cx45 cells showed extensive intercellular passage of neurobiotin but little coupling with Lucifer yellow.	Histidine	47-50	gap junction protein gamma 1	Homo sapiens	197-201
11859082-5	2002	Removal of Asp(64) and His(187), which are involved in stabilization of the cationic sugar and the anionic uracil leaving group, respectively, specifically weakens binding of I to the UDG-uracil complex by 154,000-fold, without significantly affecting substrate or product binding.	Histidine	23-26	uracil DNA glycosylase	Homo sapiens	184-187
11893736-0	2002	Importance of the histidine ligand to coenzyme B12 in the reaction catalyzed by methylmalonyl-CoA mutase.	Histidine	18-27	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	47-50
12805914-0	2002	Attachment of histidine tags to recombinant tumor necrosis factor-alpha drastically changes its properties.	Histidine	14-23	tumor necrosis factor	Mus musculus	44-71
12805914-1	2002	When studying two different histidine tags attached to the N-termini of the trimeric cytokine tumor necrosis factor alpha (TNF), the biological activity--measured as cytotoxicity on the L-929 cell line--of both tagged proteins was drastically reduced.	Histidine	28-37	tumor necrosis factor	Mus musculus	94-121
12805914-1	2002	When studying two different histidine tags attached to the N-termini of the trimeric cytokine tumor necrosis factor alpha (TNF), the biological activity--measured as cytotoxicity on the L-929 cell line--of both tagged proteins was drastically reduced.	Histidine	28-37	tumor necrosis factor	Mus musculus	123-126
11884399-5	2002	Interestingly, when the C termini of CycT1 and CycT2 or only the histidine-rich stretch from positions 481 to 551 in CycT1 were added to CycK, the extended chimeras activated transcription equivalently via DNA.	Histidine	65-74	cyclin T1	Homo sapiens	117-122
12054542-1	2002	Arabidopsis ARR4/ATRR1/IBC7 and ARR8/ATRR3 are homologous genes of prokaryotic response regulators that are involved in the His-Asp phosphorelay signal transduction.	Histidine	124-127	response regulator 3	Arabidopsis thaliana	32-36
12054542-1	2002	Arabidopsis ARR4/ATRR1/IBC7 and ARR8/ATRR3 are homologous genes of prokaryotic response regulators that are involved in the His-Asp phosphorelay signal transduction.	Histidine	124-127	response regulator 3	Arabidopsis thaliana	37-42
11966977-6	2002	For these peptides, the affinity and activity at all three human receptors (MC3R, MC4R and MC5R) decreased significantly, demonstrating that the His-Phe-Arg-Trp sequence in gamma-MSH is important for activity at these three melanocortin receptors.	Histidine	145-148	proopiomelanocortin	Homo sapiens	173-182
11940532-3	2002	To identify potential sites of domain-domain interaction within CFTR, we expressed, purified, and refolded histidine (His)- and glutathione-S-transferase (GST)-tagged cytoplasmic domains of CFTR.	Histidine	107-116	CF transmembrane conductance regulator	Homo sapiens	64-68
11940532-3	2002	To identify potential sites of domain-domain interaction within CFTR, we expressed, purified, and refolded histidine (His)- and glutathione-S-transferase (GST)-tagged cytoplasmic domains of CFTR.	Histidine	118-121	CF transmembrane conductance regulator	Homo sapiens	64-68
11940532-8	2002	To identify specific sites of interaction between domains of CFTR, an overlay assay was used to probe an overlapping peptide library spanning all intracellular regions of CFTR with his-NBD1, his-NBD2, and GST-R-domain.	Histidine	181-184	CF transmembrane conductance regulator	Homo sapiens	61-65
11940532-8	2002	To identify specific sites of interaction between domains of CFTR, an overlay assay was used to probe an overlapping peptide library spanning all intracellular regions of CFTR with his-NBD1, his-NBD2, and GST-R-domain.	Histidine	181-184	CF transmembrane conductance regulator	Homo sapiens	171-175
11973426-8	2002	Furthermore, intracerebral ventricular infusion of the relatively specific caspase-9 inhibitor N-benzyloxycarbonyl-Leu-Glu-His-Asp-fluoro-methylketone before ischemia attenuated caspase-3-like activity and significantly enhanced neuronal survival in the CA1 sector.	Histidine	123-126	caspase 9	Rattus norvegicus	75-84
11966977-8	2002	This study highlights the role played by the His-Phe-Arg-Trp sequence in receptor binding and in agonist activity of gamma-MSH.	Histidine	45-48	proopiomelanocortin	Homo sapiens	117-126
12015147-3	2002	We have determined the structure of CH1(1), a 27-residue peptide derived from the first cysteine/histidine-rich region (CH1) of CREB binding protein (CBP).	Histidine	97-106	CREB binding protein	Homo sapiens	128-148
12015147-3	2002	We have determined the structure of CH1(1), a 27-residue peptide derived from the first cysteine/histidine-rich region (CH1) of CREB binding protein (CBP).	Histidine	97-106	CREB binding protein	Homo sapiens	150-153
12051859-2	2002	A histidine-tagged form of pb5 was overproduced and purified.	Histidine	2-11	receptor-binding tail protein	Escherichia phage T5	27-30
11884585-2	2002	The HAT domains of CBP and p300 are characterized by the presence of a highly conserved putative plant homeodomain (PHD) (C4HC3) type zinc finger, which is part of the functionally uncharacterized cysteine-histidine-rich region 2 (CH2).	Histidine	206-215	CREB binding protein	Homo sapiens	19-22
11959990-2	2002	We report the solution structure of the cysteine/histidine-rich 1 (CH1) domain of p300 bound to the C-terminal transactivation domain of HIF-1 alpha.	Histidine	49-58	hypoxia inducible factor 1 subunit alpha	Homo sapiens	137-148
11903057-3	2002	Both eIF4A and HCV NS3 helicase domain were expressed in bacterial cells as histidine-tagged proteins and purified to homogeneity.	Histidine	76-85	eukaryotic translation initiation factor 4A1	Homo sapiens	5-10
11996884-10	2002	Individual mutations of the three residues where rAGT and mAGT differ in this region showed that the principal reason for the reduced ability of the mAGT to react with BG was the presence of a histidine residue at position 161, which is occupied by asparagine in rAGT and hAGT.	Histidine	193-202	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	58-62
11996884-10	2002	Individual mutations of the three residues where rAGT and mAGT differ in this region showed that the principal reason for the reduced ability of the mAGT to react with BG was the presence of a histidine residue at position 161, which is occupied by asparagine in rAGT and hAGT.	Histidine	193-202	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	149-153
12013404-0	2002	Effect of repeated L-histidine administration on plasma prolactin and growth hormone levels in rats.	Histidine	19-30	prolactin	Rattus norvegicus	56-65
11866428-4	2002	Localisation of OST48 was not affected by substitution of the two lysines by histidine, indicating that a His-Xaa-His sequence, in contrast to Arg-Xaa-Arg, contains ER-specific targeting information.	Histidine	106-109	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	16-21
11948395-6	2002	CP-31398 also decreased sequence-specific DNA binding of wild-type p53 and His-273 mutant p53.	Histidine	75-78	tumor protein p53	Homo sapiens	90-93
11866428-4	2002	Localisation of OST48 was not affected by substitution of the two lysines by histidine, indicating that a His-Xaa-His sequence, in contrast to Arg-Xaa-Arg, contains ER-specific targeting information.	Histidine	114-117	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	16-21
11741986-7	2002	The sequence of the protease domain carried the essential triad His, Asp, and Ser and showed some similarity to that of TMPRSS2, hepsin, HAT, MT-SP1, TMPRSS3, and corin, sharing 45.5, 41.9, 41.3, 40.3, 39.1, and 38.5% identity, respectively.	Histidine	64-67	transmembrane serine protease 2	Homo sapiens	120-127
11944969-2	2002	Recombinant goldfish prolactin was expressed mainly as insoluble inclusion bodies in the form of N-terminal 6x His-tagged fusion protein.	Histidine	111-114	prolactin	Homo sapiens	21-30
12171248-7	2002	This suggests that the coordinated change of Gln and His of TGF-beta1 to Thr and Ile at positions 67 and 68 alters the specificity of TGF-beta.	Histidine	53-56	transforming growth factor beta 1	Homo sapiens	60-69
12171248-7	2002	This suggests that the coordinated change of Gln and His of TGF-beta1 to Thr and Ile at positions 67 and 68 alters the specificity of TGF-beta.	Histidine	53-56	transforming growth factor beta 1	Homo sapiens	60-68
11741986-7	2002	The sequence of the protease domain carried the essential triad His, Asp, and Ser and showed some similarity to that of TMPRSS2, hepsin, HAT, MT-SP1, TMPRSS3, and corin, sharing 45.5, 41.9, 41.3, 40.3, 39.1, and 38.5% identity, respectively.	Histidine	64-67	corin, serine peptidase	Homo sapiens	163-168
11847269-5	2002	However, a his-tagged form of wild-type FGF-1 (C222(1)) and a his-tagged Leu44--&gt;Phe mutant (C2) adopt a 3:3 beta-hairpin (containing a type I" turn) for this same region.	Histidine	11-14	fibroblast growth factor 1	Homo sapiens	40-45
11835502-3	2002	Removal of the constraint provided by covalent attachment of the proximal histidine to the F-helices of these proteins decreases oxygen affinity in Lba and increases oxygen affinity in Mb, mainly because of changes in oxygen dissociation rate constants.	Histidine	74-83	leghemoglobin A	Glycine max	148-151
11847269-4	2002	This region in the wild-type FGF-1 structure (P2(1), four molecules/asu), a his-tagged His93--&gt;Gly mutant (P2(1), three molecules/asu) and a his-tagged Asn106--&gt;Gly mutant (P2(1)2(1)2(1)) adopts a 3:5 beta-hairpin known as a type I (1-4) G1 beta-bulge (containing a type I turn).	Histidine	1-4	fibroblast growth factor 1	Homo sapiens	29-34
11835502-7	2002	On the contrary, the F7 residue in Lba lacks this property and allows the proximal histidine to assume a conformation favorable for higher ligand binding affinity.	Histidine	83-92	leghemoglobin A	Glycine max	35-38
11891044-4	2002	All these HELP domain-containing proteins, including mouse KE4, Drosophila Catsup, and Arabidopsis IAR1, possessed multipass transmembrane domains and histidine-rich sequences.	Histidine	151-160	Catecholamines up	Drosophila melanogaster	75-81
11891044-4	2002	All these HELP domain-containing proteins, including mouse KE4, Drosophila Catsup, and Arabidopsis IAR1, possessed multipass transmembrane domains and histidine-rich sequences.	Histidine	151-160	ZIP metal ion transporter family	Arabidopsis thaliana	99-103
11896765-4	2002	Microinjection of a His-tagged HdCdtB subunit, homologous to the mammalian DNase I, was sufficient to induce re-localization of the Mre11 complex 1 h post treatment.	Histidine	20-23	MRE11 homolog, double strand break repair nuclease	Homo sapiens	132-137
11689574-5	2002	The open r-DGL structure confirms the previous description of the HGL catalytic triad (Ser(153), His(353), and Asp(324)) with the catalytic serine buried and an oxyanion hole (NH groups of Gln(154) and Leu(67)).	Histidine	97-100	lipase F, gastric type	Homo sapiens	66-69
11897357-0	2002	Histidine pK(a) values for the N-lobe of human transferrin: effect of substitution of binding site Asp by Ser (D63S).	Histidine	0-9	transferrin	Homo sapiens	47-58
11751821-6	2002	The pilK, pilR, and pilT products were produced with a C-terminal His tag and then detected by anti-His tag antibody.	Histidine	66-69	PilT	Escherichia coli	20-24
11779112-8	2002	The presence of an analogous metal-binding site in human growth hormone, which is located in the hydrophobic core, and our experimental finding that oxidation was greatest for (22)His and (170)His in bGH suggests that (22)His and (170)His of bGH participate in metal binding.	Histidine	180-183	growth hormone 1	Homo sapiens	57-71
11779112-8	2002	The presence of an analogous metal-binding site in human growth hormone, which is located in the hydrophobic core, and our experimental finding that oxidation was greatest for (22)His and (170)His in bGH suggests that (22)His and (170)His of bGH participate in metal binding.	Histidine	193-196	growth hormone 1	Homo sapiens	57-71
11779112-8	2002	The presence of an analogous metal-binding site in human growth hormone, which is located in the hydrophobic core, and our experimental finding that oxidation was greatest for (22)His and (170)His in bGH suggests that (22)His and (170)His of bGH participate in metal binding.	Histidine	193-196	growth hormone 1	Homo sapiens	57-71
11779112-8	2002	The presence of an analogous metal-binding site in human growth hormone, which is located in the hydrophobic core, and our experimental finding that oxidation was greatest for (22)His and (170)His in bGH suggests that (22)His and (170)His of bGH participate in metal binding.	Histidine	193-196	growth hormone 1	Homo sapiens	57-71
11779112-9	2002	This result is supported by a previously predicted tertiary structure of bGH and compared with the location of metal-binding His residues of human growth hormone.	Histidine	125-128	growth hormone 1	Homo sapiens	147-161
11752394-4	2002	The haem is covalently attached to sGC at His-105 of the beta1 subunit, and it was thought previously that activation of sGC by NO occurs in two steps: binding of NO to the haem to form a biliganded state and then rupture of the bond to His-105 triggering an increase in catalytic activity.	Histidine	42-45	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	57-62
11752394-4	2002	The haem is covalently attached to sGC at His-105 of the beta1 subunit, and it was thought previously that activation of sGC by NO occurs in two steps: binding of NO to the haem to form a biliganded state and then rupture of the bond to His-105 triggering an increase in catalytic activity.	Histidine	237-240	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	57-62
11782371-5	2002	The rescue function mapped to the cysteine-histidine rich domain CH3, a region of p300/CBP that we found to interact directly with the conserved COOH-terminal activation domain (AF-2) of ER-alpha.	Histidine	43-52	CREB binding protein	Homo sapiens	87-90
11782371-5	2002	The rescue function mapped to the cysteine-histidine rich domain CH3, a region of p300/CBP that we found to interact directly with the conserved COOH-terminal activation domain (AF-2) of ER-alpha.	Histidine	43-52	estrogen receptor 1	Homo sapiens	187-195
11750849-4	2002	Four hours after transfection with ivt-CEA/HisC-mRNA, we detected specific expression of CEA and the histidine-tag by immunofluorescence microscopy and by FACS.	Histidine	101-110	CEA cell adhesion molecule 3	Homo sapiens	39-42
11785951-2	2002	Based on the sequence homology between rabbit muscle PFK and two bacterial PFKs and the crystal structures of the latter, Ser(530), Arg(292) and His(662) of the rabbit enzyme are implicated as binding sites for Fru-2,6-P(2).	Histidine	145-148	ATP-dependent 6-phosphofructokinase, muscle type	Oryctolagus cuniculus	53-56
11785967-0	2002	Modification of histidine (B10) is the causative agent for a superactive form of insulin.	Histidine	16-25	insulin	Homo sapiens	81-88
11785967-3	2002	It was found that the insulin was bound to the resin through histidine B10, His (B10), and its ammonium bicarbonate-mediated release resulted in an insulin analog in which His (B10) was modified on the imidazole ring.	Histidine	61-70	insulin	Homo sapiens	22-29
11785967-3	2002	It was found that the insulin was bound to the resin through histidine B10, His (B10), and its ammonium bicarbonate-mediated release resulted in an insulin analog in which His (B10) was modified on the imidazole ring.	Histidine	61-70	insulin	Homo sapiens	148-155
11785967-3	2002	It was found that the insulin was bound to the resin through histidine B10, His (B10), and its ammonium bicarbonate-mediated release resulted in an insulin analog in which His (B10) was modified on the imidazole ring.	Histidine	76-79	insulin	Homo sapiens	22-29
11785967-6	2002	Since Asp (B10) insulin is also superactive, the observed superactivity may thus stem from either modification of the histidine or its conversion to aspartic acid.	Histidine	118-127	insulin	Homo sapiens	16-23
11814676-2	2002	This cDNA coded for a protein with nine Cys(2)His(2) zinc fingers and a non-finger C-terminal tail; 63% amino acid (aa) sequence identity was observed with the Xenopus TFIIIA zinc finger region.	Histidine	46-49	general transcription factor IIIA	Homo sapiens	168-174
11782367-7	2002	Transient expression of dominant-negative p53 ((175)Arg--&gt;His) counteracted the detrimental effects of BPDE on BRCA-1 promoter activity and protein levels.	Histidine	61-64	tumor protein p53	Homo sapiens	42-45
11751821-6	2002	The pilK, pilR, and pilT products were produced with a C-terminal His tag and then detected by anti-His tag antibody.	Histidine	100-103	PilT	Escherichia coli	20-24
11860113-0	2002	Effects of abomasal infusions of histidine, glucose, and leucine on milk production and plasma metabolites of dairy cows fed grass silage diets.	Histidine	33-42	Weaning weight-maternal milk	Bos taurus	68-72
16233267-1	2002	In an attempt to produce a bovine pancreatic ribonuclease A (RNase A) with increased activity and stability, the catalytic pair of His12 and His119 was substituted with aspartic acid or glutamic acid, and aspartic acid, respectively, to evaluate the role of the two histidine residues in the activity and stability.	Histidine	266-275	ribonuclease pancreatic	Bos taurus	45-59
16233267-1	2002	In an attempt to produce a bovine pancreatic ribonuclease A (RNase A) with increased activity and stability, the catalytic pair of His12 and His119 was substituted with aspartic acid or glutamic acid, and aspartic acid, respectively, to evaluate the role of the two histidine residues in the activity and stability.	Histidine	266-275	ribonuclease pancreatic	Bos taurus	61-68
11860113-10	2002	Responses in milk protein yield to combined infusions of His and glucose were additive, suggesting that the utilization of the first-limiting AA His was limited by glucose supply.	Histidine	57-60	Weaning weight-maternal milk	Bos taurus	13-17
11902667-2	2002	A histidine-specific modifier, diethylpyrocarbonate (DEPC), could substantially inhibit enzymic activity and H+-translocation of vacuolar H+-PPase in a concentration-dependent manner.	Histidine	2-11	inorganic pyrophosphatase 1	Homo sapiens	141-146
11902667-8	2002	A reaction order of 0.85 was calculated from a double logarithmic plot of the apparent reaction constant against DEPC concentration, suggesting that the modification of one single histidine residue on the enzyme suffices to inhibit vacuolar H+-PPase.	Histidine	180-189	inorganic pyrophosphatase 1	Homo sapiens	244-249
11902667-13	2002	Taken together, we suggest that vacuolar H+-PPase likely contains a substrate-protectable histidine residue contributing to the inhibition of its activity by DEPC, and this histidine residue may located in a domain sensitive to the modification of Cys-629 by NEM.	Histidine	90-99	inorganic pyrophosphatase 1	Homo sapiens	44-49
11902667-13	2002	Taken together, we suggest that vacuolar H+-PPase likely contains a substrate-protectable histidine residue contributing to the inhibition of its activity by DEPC, and this histidine residue may located in a domain sensitive to the modification of Cys-629 by NEM.	Histidine	173-182	inorganic pyrophosphatase 1	Homo sapiens	44-49
11739744-5	2002	A histidine-rich stretch, which is conserved between CycT1 and CycT2 in this region, bound the C-terminal domain of RNAPII.	Histidine	2-11	cyclin T1	Homo sapiens	53-58
11840265-3	2002	Extracellular domain of human TRAIL with N-terminal His(6) tag (His-TRAIL, amino acids 95-281) was produced in E. coli and its apoptosis-inducing ability was compared with the leucine-zipper containing TRAIL, LZ-TRAIL.	Histidine	52-55	TNF superfamily member 10	Homo sapiens	30-35
11840265-3	2002	Extracellular domain of human TRAIL with N-terminal His(6) tag (His-TRAIL, amino acids 95-281) was produced in E. coli and its apoptosis-inducing ability was compared with the leucine-zipper containing TRAIL, LZ-TRAIL.	Histidine	64-67	TNF superfamily member 10	Homo sapiens	30-35
11840265-3	2002	Extracellular domain of human TRAIL with N-terminal His(6) tag (His-TRAIL, amino acids 95-281) was produced in E. coli and its apoptosis-inducing ability was compared with the leucine-zipper containing TRAIL, LZ-TRAIL.	Histidine	64-67	TNF superfamily member 10	Homo sapiens	68-73
11840265-3	2002	Extracellular domain of human TRAIL with N-terminal His(6) tag (His-TRAIL, amino acids 95-281) was produced in E. coli and its apoptosis-inducing ability was compared with the leucine-zipper containing TRAIL, LZ-TRAIL.	Histidine	64-67	TNF superfamily member 10	Homo sapiens	68-73
11840265-3	2002	Extracellular domain of human TRAIL with N-terminal His(6) tag (His-TRAIL, amino acids 95-281) was produced in E. coli and its apoptosis-inducing ability was compared with the leucine-zipper containing TRAIL, LZ-TRAIL.	Histidine	64-67	TNF superfamily member 10	Homo sapiens	68-73
11840265-7	2002	Moreover, we found that normal human stem cells treated with high doses of His-TRAIL maintain a repopulating potential when transplanted into NOD/SCID mice.	Histidine	75-78	TNF superfamily member 10	Homo sapiens	79-84
11972886-6	2002	However, DRB1*14011 also has a non-synonymous substitution at the first base of codon 112 which results in a histidine to tyrosine substitution.	Histidine	109-118	major histocompatibility complex, class II, DR beta 1	Homo sapiens	9-13
11828030-0	2002	An Arabidopsis histidine-containing phosphotransfer (HPt) factor implicated in phosphorelay signal transduction: overexpression of AHP2 in plants results in hypersensitiveness to cytokinin.	Histidine	15-24	histidine-containing phosphotransmitter 2	Arabidopsis thaliana	131-135
11972886-7	2002	This is a novel substitution as Histidine 112 is conserved in all known HLA class II B genes.	Histidine	32-41	major histocompatibility complex, class II, DR beta 1	Homo sapiens	72-75
11724898-2	2001	The technique was developed using a recombinant human insulin-like growth factor (IGF-1) chimera, bearing six additional histidine residues at the carboxy-terminal end (IGF-1-His).	Histidine	175-178	insulin like growth factor 1	Homo sapiens	169-174
11739191-2	2001	A 68.5-kd chimeric protein (His-M195FANCF) was expressed, consisting of a His tag, a single-chain antibody to the myeloid antigen CD33, and the FANCF protein, as well as a 43-kd His-FANCF fusion protein lacking the antibody motif, in Escherichia coli.	Histidine	28-31	CD33 molecule	Homo sapiens	130-134
11739191-3	2001	The nickel-agarose-purified His-M195FANCF protein bound specifically to the surface of HeLa cells transfected with CD33 and internalized through vesicular structures.	Histidine	28-31	CD33 molecule	Homo sapiens	115-119
11739191-8	2001	Treatment of CD33-transfected FA group F lymphoblastoid cells with 0.1 mg/mL His-M195FANCF conferred resistance to mitomycin C.	Histidine	77-80	CD33 molecule	Homo sapiens	13-17
11753565-4	2001	Cleavage of caspase-9 was detected approximately 4 h following seizure cessation within ipsilateral hippocampus and was accompanied by increased cleavage of the substrate Leu-Glu-His-Asp-p-nitroanilide (LEHDpNA) and subsequent strong caspase-9 immunoreactivity within neurons exhibiting DNA fragmentation.	Histidine	179-182	caspase 9	Rattus norvegicus	12-21
11753565-4	2001	Cleavage of caspase-9 was detected approximately 4 h following seizure cessation within ipsilateral hippocampus and was accompanied by increased cleavage of the substrate Leu-Glu-His-Asp-p-nitroanilide (LEHDpNA) and subsequent strong caspase-9 immunoreactivity within neurons exhibiting DNA fragmentation.	Histidine	179-182	caspase 9	Rattus norvegicus	234-243
11724898-4	2001	The specificity of IGF-1-His interaction was shown by gradual abolition of the fluorescent signal in the presence of increasing concentrations of IGF-1.	Histidine	25-28	insulin like growth factor 1	Homo sapiens	19-24
11724898-4	2001	The specificity of IGF-1-His interaction was shown by gradual abolition of the fluorescent signal in the presence of increasing concentrations of IGF-1.	Histidine	25-28	insulin like growth factor 1	Homo sapiens	146-151
11724898-6	2001	Moreover, incubation of the tissue sections with an anti-IGFR-1 blocking antibody abolished IGF-1-His binding, demonstrating that the interaction was mediated by the IGFR-1.	Histidine	98-101	insulin like growth factor 1	Homo sapiens	92-97
11724898-8	2001	The IGF-1-His binding pattern was observed in brain, cartilage, lung, skin, heart, diaphragm, and tongue, and paralleled the previously reported IGFR-1 distribution.	Histidine	10-13	insulin like growth factor 1	Homo sapiens	4-9
11487579-6	2001	This approach is complicated by the breakage of the proximal His-Fe bond that may occur as a consequence of CO photodissociation in the unfolded cytochrome c because of the so-called base elimination mechanism.	Histidine	61-64	cytochrome c, somatic	Homo sapiens	145-157
11798469-6	2001	An extensive analysis of the pegylated positional isomers revealed that approximately 50% of PEG Intron was monopegylated on the His(34) residue of the IFN-alpha2b protein.	Histidine	129-132	interferon alpha 1	Homo sapiens	152-155
11571292-4	2001	The exceptions to this result were two mimetics of a short FGF1 sequence, which has been shown to interact with the region of the FGFR containing the histidine-alanine-valine motif.	Histidine	150-159	fibroblast growth factor 1	Homo sapiens	59-63
11535593-11	2001	Modeling of the C-terminal domain of the CaR indicated that His(880) and Phe(882) are situated in a putative alpha-helical structure of 15 amino acids between residues 877 and 891 in the C-terminal tail.	Histidine	60-63	calcium sensing receptor	Homo sapiens	41-44
11698662-4	2001	A single amino acid, which is tyrosine in PPAR alpha and histidine in PPAR gamma, imparts subtype selectivity for both thiazolidinedione and nonthiazolidinedione ligands.	Histidine	57-66	peroxisome proliferator activated receptor gamma	Homo sapiens	70-80
11601994-3	2001	Here we show that S. cerevisiae leukotriene A(4) hydrolase is a metalloenzyme containing one zinc atom complexed to His-340, His-344, and Glu-363.	Histidine	116-119	leukotriene A4 hydrolase	Homo sapiens	32-58
11526110-4	2001	In addition to a FYVE finger motif, the primary structure of Pib1p contains a region rich in cysteine and histidine residues that we demonstrate binds 2 mol eq of zinc, consistent with this region containing a RING structural domain.	Histidine	106-115	phosphatidylinositol-3-phosphate-binding ubiquitin-protein ligase	Saccharomyces cerevisiae S288C	61-66
11689206-2	2001	We have examined the interaction of recombinant His-tagged caveolin-1 with cholesterol and 7-keto cholesterol, the most abundant non-enzymatically formed oxysterol found in oxidised LDL and atheromatous plaque.	Histidine	48-51	caveolin 1	Homo sapiens	59-69
11546769-5	2001	Native DDAH-1 could be fully or partially activated using various concentrations of phosphate, imidazole, histidine, and histamine, a process that is paralleled by the release of Zn(II).	Histidine	106-115	dimethylarginine dimethylaminohydrolase 1	Bos taurus	7-13
11676605-4	2001	The overproduced human TrpRS-His(6) could be purified to homogeneity within 2 h and about 24 mg purified enzyme could be obtained from 400 ml cell culture.	Histidine	29-32	tryptophanyl-tRNA synthetase 1	Homo sapiens	23-28
11687208-3	2001	The Chl a" and Chl a are axially coordinated by His residues provided by protein subunits PsaA and PsaB, respectively.	Histidine	48-51	fatty acid amide hydrolase	Homo sapiens	99-103
11517220-1	2001	Previous studies have demonstrated that the potency and thermodynamic stability of human insulin are enhanced in concert by substitution of Thr(A8) by arginine or histidine.	Histidine	163-172	insulin	Homo sapiens	89-96
11601994-3	2001	Here we show that S. cerevisiae leukotriene A(4) hydrolase is a metalloenzyme containing one zinc atom complexed to His-340, His-344, and Glu-363.	Histidine	125-128	leukotriene A4 hydrolase	Homo sapiens	32-58
11473116-8	2001	These results support a mechanism for copper transfer in which CCS and SOD1 dock via their highly conserved dimer interfaces in a manner that precisely orients the Cys-rich copper donor sites of CCS and the His-rich acceptor sites of SOD1 to form a copper-bridged intermediate.	Histidine	207-210	superoxide dismutase 1	Homo sapiens	71-75
11473116-8	2001	These results support a mechanism for copper transfer in which CCS and SOD1 dock via their highly conserved dimer interfaces in a manner that precisely orients the Cys-rich copper donor sites of CCS and the His-rich acceptor sites of SOD1 to form a copper-bridged intermediate.	Histidine	207-210	superoxide dismutase 1	Homo sapiens	234-238
11481322-4	2001	Direct physical interactions between the N- and C-zinc finger domains of GATA-4 and the cysteine/histidine-rich region 3 (C/H3) of p300 were identified in immunoprecipitation and glutathione S-transferase pull-down experiments.	Histidine	97-106	GATA binding protein 4	Mus musculus	73-79
11504735-5	2001	Amino-terminal amino acid sequencing of histidine-tagged Hap(beta) species and site-directed mutagenesis established that autoproteolysis occurs at LT1046-7, FA1077-8, and FS1067-8, revealing a consensus target sequence for cleavage that consists of ((Q/R)(A/S)X(L/F)) at the P4 through P1 positions.	Histidine	40-49	BAG cochaperone 1	Homo sapiens	57-60
11580253-10	2001	Consistent with this idea, Abeta peptides containing Asp-->Asn or His-->Gln substitutions showed altered fibrillogenesis kinetics.	Histidine	66-69	amyloid beta precursor protein	Homo sapiens	27-32
11560479-2	2001	Accordingly, we employed a model phosphorylation system consisting of purified PKC, gamma-S-[(32)P]ATP, and either native or CuOOH-inactivated purified recombinant His(6)-tagged CYP3A4.	Histidine	164-167	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	178-184
11686802-3	2001	Responses of milk protein secretion to infusion of histidine were seen only when the diet contained a supplement of barley alone.	Histidine	51-60	casein beta	Bos taurus	13-25
11686802-6	2001	The results confirm that, for diets based on grass silage and supplements of cereal only, histidine is first-limiting such that increases of milk protein secretion can be obtained in response to infusion of histidine alone.	Histidine	90-99	casein beta	Bos taurus	141-153
11686802-6	2001	The results confirm that, for diets based on grass silage and supplements of cereal only, histidine is first-limiting such that increases of milk protein secretion can be obtained in response to infusion of histidine alone.	Histidine	207-216	casein beta	Bos taurus	141-153
11567181-2	2001	In this paper, we examine a novel one-step method for direct 99mTc labelling of a recombinant anti-CEA scFv fragment through a C-terminal peptide tag containing a six-histidine sequence.	Histidine	167-176	CEA cell adhesion molecule 3	Homo sapiens	99-102
11567181-2	2001	In this paper, we examine a novel one-step method for direct 99mTc labelling of a recombinant anti-CEA scFv fragment through a C-terminal peptide tag containing a six-histidine sequence.	Histidine	167-176	immunglobulin heavy chain variable region	Homo sapiens	103-107
11574671-0	2001	Identification of functionally relevant histidine residues in the apoptotic nuclease CAD.	Histidine	40-49	congenital cataract	Mus musculus	85-88
11574671-3	2001	Sequence alignment of murine CAD with four homologous apoptotic nucleases reveals four completely (His242, His263, His304 and His308) and two partially (His127 and His313) conserved histidine residues in the catalytic domain of the enzyme.	Histidine	182-191	congenital cataract	Mus musculus	29-32
16201198-8	2001	The 5 x his-tagged ScFv antibodies were purified on IDA-Ni2+ resin by immobilized metal chelate affinity chromatography (IMAC).	Histidine	8-11	immunglobulin heavy chain variable region	Homo sapiens	19-23
11570867-4	2001	Surprisingly, mutagenesis of the histidine ligand, His249, to glutamine in the N-lobe half-molecule of human Tf (hTf/2N) shows that iron binding is destabilized and suggests that Gln249 does not bind to iron.	Histidine	33-42	transferrin	Homo sapiens	109-111
11447225-5	2001	Recombinant His(6)-Plk3 phosphorylated glutathione S-transferase (GST)-p53 fusion protein but not GST alone.	Histidine	12-15	polo like kinase 3	Homo sapiens	19-23
11447225-5	2001	Recombinant His(6)-Plk3 phosphorylated glutathione S-transferase (GST)-p53 fusion protein but not GST alone.	Histidine	12-15	tumor protein p53	Homo sapiens	71-74
11447225-6	2001	When phoshorylated in vitro by His(6)-Plk3, but not by the kinase-defective mutant His6-Plk3(K52R), GST-p53 was recognized by an antibody specifically to serine 20-phosphorylated p53, indicating that serine 20 is an in vitro target of Plk3.	Histidine	31-34	tumor protein p53	Homo sapiens	104-107
11461905-4	2001	In Acr2p these are residues His-75, Cys-76, and Arg-82, respectively.	Histidine	28-31	Arr2p	Saccharomyces cerevisiae S288C	3-8
11457851-8	2001	Systematic mutagenesis of the 10 extracellular histidines of ASIC2a leads to the identification of two residues (His-162 and His-339) that are essential for the Zn(2+) potentiating effect.	Histidine	47-57	acid sensing ion channel subunit 2	Homo sapiens	61-67
11457851-8	2001	Systematic mutagenesis of the 10 extracellular histidines of ASIC2a leads to the identification of two residues (His-162 and His-339) that are essential for the Zn(2+) potentiating effect.	Histidine	113-116	acid sensing ion channel subunit 2	Homo sapiens	61-67
11457851-8	2001	Systematic mutagenesis of the 10 extracellular histidines of ASIC2a leads to the identification of two residues (His-162 and His-339) that are essential for the Zn(2+) potentiating effect.	Histidine	125-128	acid sensing ion channel subunit 2	Homo sapiens	61-67
11457851-9	2001	Mutation of another histidine residue, His-72, abolishes the pH sensitivity of ASIC2a.	Histidine	20-29	acid sensing ion channel subunit 2	Homo sapiens	79-85
11457851-9	2001	Mutation of another histidine residue, His-72, abolishes the pH sensitivity of ASIC2a.	Histidine	39-42	acid sensing ion channel subunit 2	Homo sapiens	79-85
11527428-3	2001	Indeed, the model brings in contact the residues of AII responsible for agonistic activity, Tyr(4), His(6), and Phe(8), with many residues of AT-1 involved in signal transduction according to site-directed mutagenesis.	Histidine	100-103	angiotensinogen	Homo sapiens	52-55
11554793-0	2001	Localisation of the PsbH subunit in photosystem II: a new approach using labelling of His-tags with a Ni(2+)-NTA gold cluster and single particle analysis.	Histidine	86-89	photosystem II protein H	Chlamydomonas reinhardtii	20-24
11554793-1	2001	Photosystem II core dimers were isolated from the green alga Chlamydomonas reinhardtii by Ni(2+)-affinity chromatography exploiting a 6 x His tag located at the N terminus of the PsbH protein.	Histidine	138-141	photosystem II protein H	Chlamydomonas reinhardtii	179-183
11554793-3	2001	In order to identify the location of PsbH within the photosystem II complex, the His-tagged core dimers were labelled using a Ni(2+)-NTA gold cluster and subjected to electron microscopy and image analysis.	Histidine	81-84	photosystem II protein H	Chlamydomonas reinhardtii	37-41
11527429-6	2001	S100A4 had a greater affinity for wild-type or mutant arg-175-his p53 than for non-muscle myosin.	Histidine	62-65	tumor protein p53	Homo sapiens	66-69
11676033-5	2001	Together with the results from an in vitro phosphorelay assay with AHP2 and ARRs, these results are discussed, in terms of a geneal framework of the Arabidopsis His-to-Asp phosphorelay network.	Histidine	161-164	histidine-containing phosphotransmitter 2	Arabidopsis thaliana	67-71
11488596-9	2001	Histidase and formiminotransferase-cyclodeaminase, also on the histidine deamination pathway, had similar specific activities in normal and NEUT2 mice.	Histidine	63-72	histidine ammonia lyase	Mus musculus	0-9
11549352-9	2001	The recombinant histidine tagged MLK7 expressed and purified from insect cells exhibited serine/threonine kinase activity in vitro with myelin basic protein as substrate.	Histidine	16-25	mitogen-activated protein kinase kinase kinase 20	Homo sapiens	33-37
11485557-5	2001	Five residues of GST I (Ser(11), His(40), Lys(41), Gln(53) and Ser(67)), which are located in the G-site, were individually replaced with alanine and their structural and functional roles in the 1-chloro-2,4-dinitrobenzene (CDNB) conjugation reaction were investigated.	Histidine	33-36	glutathione S-transferase 1	Zea mays	17-22
11488596-9	2001	Histidase and formiminotransferase-cyclodeaminase, also on the histidine deamination pathway, had similar specific activities in normal and NEUT2 mice.	Histidine	63-72	formiminotransferase cyclodeaminase	Mus musculus	14-49
11483654-1	2001	It has recently been shown that transition metal cations Zn2+ and Cu2+ bind to histidine residues of nerve growth factor (NGF) and other neurotrophins (a family of proteins important for neuronal survival) leading to their inactivation.	Histidine	79-88	nerve growth factor	Homo sapiens	101-120
11463336-3	2001	The anosmin-1 sequence indicates an N-terminal cysteine-rich domain, a whey acidic protein (WAP) domain, four fibronectin type III (FnIII) domains and a C-terminal histidine-rich region, and shows similarity with cell-adhesion molecules, such as neural cell-adhesion molecule, TAG-1 and L1.	Histidine	164-173	anosmin 1	Homo sapiens	4-13
11469796-0	2001	Structure--function relationships of rat hepatic tryptophan 2,3-dioxygenase: identification of the putative heme-ligating histidine residues.	Histidine	122-131	tryptophan 2,3-dioxygenase	Rattus norvegicus	49-75
11469796-6	2001	In an attempt to characterize the active site of the enzyme we have substituted each of the 12 His residues in the rat TDO subunit with Ala, to determine their relative importance in heme binding.	Histidine	95-98	tryptophan 2,3-dioxygenase	Rattus norvegicus	119-122
11469796-7	2001	Sequence alignment of the rat liver protein with that of known or putative TDO sequences from other organisms reveals that four of the His residues are conserved in eukaryotes, two of which are also conserved in prokaryotes.	Histidine	135-138	tryptophan 2,3-dioxygenase	Rattus norvegicus	75-78
11469796-8	2001	Our findings indicate that replacement of the evolutionarily conserved His 76 and 328 residues resulted in a dramatic reduction of TDO activity, whereas that of the eukaryotically conserved His70 resulted in a significant reduction relative to that of the wild-type enzyme.	Histidine	71-74	tryptophan 2,3-dioxygenase	Rattus norvegicus	131-134
11469796-11	2001	Whether these His residues are both provided by the same TDO subunit or a different TDO subunit remains to be determined.	Histidine	14-17	tryptophan 2,3-dioxygenase	Rattus norvegicus	57-60
11469796-11	2001	Whether these His residues are both provided by the same TDO subunit or a different TDO subunit remains to be determined.	Histidine	14-17	tryptophan 2,3-dioxygenase	Rattus norvegicus	84-87
11483654-1	2001	It has recently been shown that transition metal cations Zn2+ and Cu2+ bind to histidine residues of nerve growth factor (NGF) and other neurotrophins (a family of proteins important for neuronal survival) leading to their inactivation.	Histidine	79-88	nerve growth factor	Homo sapiens	122-125
11483654-7	2001	These data demonstrate that Cu2+ has greater binding affinity to NGF than Zn2+ at reduced pH, consistent with the higher affinity of Cu2+ for histidine residues.	Histidine	142-151	nerve growth factor	Homo sapiens	65-68
11468363-5	2001	Phosphate binds to the catalytic site of both Ang and Q117G in essentially the same manner observed in the RNase A-phosphate complex, forming hydrogen bonds with the side chains of His 13, His 114, and Gln 12, and the main chain of Leu 115; it makes an additional interaction with the Lys 40 ammonium group in the Ang complex.	Histidine	181-184	ribonuclease pancreatic	Bos taurus	107-114
11468363-5	2001	Phosphate binds to the catalytic site of both Ang and Q117G in essentially the same manner observed in the RNase A-phosphate complex, forming hydrogen bonds with the side chains of His 13, His 114, and Gln 12, and the main chain of Leu 115; it makes an additional interaction with the Lys 40 ammonium group in the Ang complex.	Histidine	189-192	ribonuclease pancreatic	Bos taurus	107-114
11346639-0	2001	Mutational and kinetic evaluation of conserved His-123 in dual specificity protein-tyrosine phosphatase vaccinia H1-related phosphatase: participation of Tyr-78 and Thr-73 residues in tuning the orientation of His-123.	Histidine	47-50	dual specificity phosphatase 3	Homo sapiens	104-135
11346639-0	2001	Mutational and kinetic evaluation of conserved His-123 in dual specificity protein-tyrosine phosphatase vaccinia H1-related phosphatase: participation of Tyr-78 and Thr-73 residues in tuning the orientation of His-123.	Histidine	210-213	dual specificity phosphatase 3	Homo sapiens	104-135
11346639-2	2001	In this work, we investigated the structural role of histidine array in HC(X)(5)RS motif of the vaccinia H1-related protein phosphatase (VHR), using site-directed mutagenesis in conjunction with an extensive kinetic analysis.	Histidine	53-62	dual specificity phosphatase 3	Homo sapiens	96-135
11346639-2	2001	In this work, we investigated the structural role of histidine array in HC(X)(5)RS motif of the vaccinia H1-related protein phosphatase (VHR), using site-directed mutagenesis in conjunction with an extensive kinetic analysis.	Histidine	53-62	dual specificity phosphatase 3	Homo sapiens	137-140
11434776-12	2001	Mutagenesis of either His-111, Met-109, or Met-112 abolished PrP106-126 neurotoxicity and its ability to form fibrils.	Histidine	22-25	prion protein	Homo sapiens	61-71
11461677-4	2001	In addition, NT-3 and NT-4 sequences contained additional substitutions, including asparagine at position 22, lysine at position 77 and histidine at position 110, that were absent in transmitting mother and consensus subtype B sequences.	Histidine	136-145	neurotrophin 4	Homo sapiens	22-26
11439052-0	2001	Kinetics of histidine deligation from the heme in GuHCl-unfolded Fe(III) cytochrome C studied by a laser-induced pH-jump technique.	Histidine	12-21	cytochrome c, somatic	Homo sapiens	73-85
11439052-5	2001	Using this pH-jump/transient absorption technique, we have examined the dissociation kinetics of non-native axial heme ligands (either histidine His26 or His33) in GuHCl-unfolded Fe(III) cytochrome c (cyt c).	Histidine	135-144	cytochrome c, somatic	Homo sapiens	187-199
11439052-9	2001	The activation energies of the deligation processes support the suggestion that GuHCl-unfolded cyt c structures with non-native histidine axial ligands represent kinetic traps in unfolding.	Histidine	128-137	cytochrome c, somatic	Homo sapiens	95-100
11415439-2	2001	They contain two and three thioredoxin boxes (Cys-Gly-His-Cys) respectively and, like PDI, may be involved in the folding of nascent proteins.	Histidine	54-57	thioredoxin 1	Rattus norvegicus	27-38
11485167-6	2001	Also, it was an attractive hypothesis to suggest that HNE may disrupt the active site by forming a Michael adduct with one or more of the three histidines that ligate the iron active site of LOX-1.	Histidine	144-154	seed linoleate 13S-lipoxygenase-1	Glycine max	191-196
11453725-15	2001	The reason for the high reactivity of cysteine 86 in rGSTM1 was hypothesized to be due to its potential interaction with histidine 84, which is unique in this subunit.	Histidine	121-130	glutathione S-transferase mu 1	Rattus norvegicus	53-59
11422751-1	2001	BACKGROUND: Connexin 40 (Cx40) is a gap junction protein expressed in endothelial cells of vessels, endocardium, and conducting cells of the His-Purkinje system of heart.	Histidine	141-144	gap junction protein, alpha 5	Rattus norvegicus	12-23
11422751-1	2001	BACKGROUND: Connexin 40 (Cx40) is a gap junction protein expressed in endothelial cells of vessels, endocardium, and conducting cells of the His-Purkinje system of heart.	Histidine	141-144	gap junction protein, alpha 5	Rattus norvegicus	25-29
11320079-0	2001	On the role of conserved histidine 106 in 10-formyltetrahydrofolate dehydrogenase catalysis: connection between hydrolase and dehydrogenase mechanisms.	Histidine	25-34	aldehyde dehydrogenase 1 family member L1	Homo sapiens	42-81
11320079-6	2001	In the present work we studied the role of the conserved histidine, His(106), in FDH function.	Histidine	57-66	aldehyde dehydrogenase 1 family member L1	Homo sapiens	81-84
11320079-6	2001	In the present work we studied the role of the conserved histidine, His(106), in FDH function.	Histidine	68-71	aldehyde dehydrogenase 1 family member L1	Homo sapiens	81-84
11320079-7	2001	Site-directed mutagenesis experiments showed that replacement of the histidine with alanine, asparagine, aspartate, glutamate, glutamine, or arginine in N(t)-FDH resulted in expression of insoluble proteins.	Histidine	69-78	aldehyde dehydrogenase 1 family member L1	Homo sapiens	153-161
11320079-11	2001	Expressed full-length FDH with the substitution of lysine for the His(106) completely lost both the hydrolase and dehydrogenase activities.	Histidine	66-69	aldehyde dehydrogenase 1 family member L1	Homo sapiens	22-25
11320079-12	2001	Thus, our study showed that His(106), besides being an important structural residue, is also directly involved in both the hydrolase and dehydrogenase mechanisms of FDH.	Histidine	28-31	aldehyde dehydrogenase 1 family member L1	Homo sapiens	165-168
11274207-4	2001	Here we show that coordination of metal ions to Abeta is the same in both aqueous solution and lipid environments, with His(6), His(13), and His(14) all involved.	Histidine	120-123	amyloid beta precursor protein	Homo sapiens	48-53
11274207-4	2001	Here we show that coordination of metal ions to Abeta is the same in both aqueous solution and lipid environments, with His(6), His(13), and His(14) all involved.	Histidine	128-131	amyloid beta precursor protein	Homo sapiens	48-53
11274207-8	2001	These results suggest that metal binding to Abeta generated an allosterically ordered membrane-penetrating oligomer linked by superoxide dismutase-like bridging histidine residues.	Histidine	161-170	amyloid beta precursor protein	Homo sapiens	44-49
11423992-6	2001	PDT-induced Bcl-2 loss occurred in MCF-7 cells that do not express caspase-3 or in the presence of protease inhibitors, but was prevented, along with the induction of apoptosis, by the singlet oxygen scavenger L-histidine.	Histidine	210-221	BCL2 apoptosis regulator	Homo sapiens	12-17
11369803-4	2001	A high level of recombinant hPON1 type A (rPON1A) was produced by Hi-5 insect cells (40 mg/l); a fraction ( approximately 10 mg/l) was secreted into the cell culture medium, but the majority ( approximately 30 mg/l) remained associated with the host insect cells.	Histidine	66-68	paraoxonase 1	Homo sapiens	28-33
11551383-0	2001	Interaction of Cu(2+) with His-Val-His and of Zn(2+) with His-Val-Gly-Asp, two peptides surrounding metal ions in Cu,Zn-superoxide dismutase enzyme.	Histidine	27-30	superoxide dismutase 1	Homo sapiens	114-140
11551383-1	2001	His-Val-His and His-Val-Gly-Asp are two naturally occurring peptide sequences, present at the active site of Cu,Zn-superoxide dismutase (Cu,Zn-SOD).	Histidine	0-3	superoxide dismutase 1	Homo sapiens	109-135
11551383-1	2001	His-Val-His and His-Val-Gly-Asp are two naturally occurring peptide sequences, present at the active site of Cu,Zn-superoxide dismutase (Cu,Zn-SOD).	Histidine	0-3	superoxide dismutase 1	Homo sapiens	137-146
11432989-10	2001	The contribution of the low-sensitivity sites to current kinetics was reduced or almost abolished in oocytes expressing His-hP2X(7) or His-hP2X(7)DeltaC.	Histidine	120-123	purinergic receptor P2X 7	Homo sapiens	124-131
11371582-5	2001	Also, human growth hormone receptor (GHR) displays species specificity; i.e., it can interact only with human (or rhesus monkey) GH, not with nonprimate GHS: The species specificity of human GHR is largely due to the Leu--&gt;Arg change at position 43, and it has been hypothesized that this change must have been preceded by the His--&gt;Asp change at position 171 of GH.	Histidine	330-333	growth hormone 1	Homo sapiens	37-39
11380500-5	2001	RESULTS: Both affected individuals were compound heterozygotes for two previously undescribed GHRH-R mutations: a change in codon 137 that replaces histidine with leucine (H137L), and a 5 bp deletion in exon 11 (Del 1140-1144).	Histidine	148-157	growth hormone releasing hormone receptor	Homo sapiens	94-100
11336800-0	2001	Zinc(II)-mediated enhancement of the agonist activity of histidine-substituted parathyroid hormone(1-14) analogues.	Histidine	57-66	parathyroid hormone	Rattus norvegicus	79-98
11333221-4	2001	Site-specific mutagenesis of the predicted protease active site cysteine and histidine residues of Smt4p abolishes the SMT4 function in vivo.	Histidine	77-86	SUMO protease ULP2	Saccharomyces cerevisiae S288C	99-104
11333221-4	2001	Site-specific mutagenesis of the predicted protease active site cysteine and histidine residues of Smt4p abolishes the SMT4 function in vivo.	Histidine	77-86	SUMO protease ULP2	Saccharomyces cerevisiae S288C	119-123
11377692-1	2001	The N-terminal region of bovine serum albumin (Asp-Thr-His-Lys) is known to provide a specific binding site for Cu(II) ions, with the histidine residue thought to be mainly responsible for the specificity.	Histidine	55-58	albumin	Homo sapiens	32-45
11377692-1	2001	The N-terminal region of bovine serum albumin (Asp-Thr-His-Lys) is known to provide a specific binding site for Cu(II) ions, with the histidine residue thought to be mainly responsible for the specificity.	Histidine	134-143	albumin	Homo sapiens	32-45
11377692-3	2001	As part of a series of studies to study the interactions between Cu(II), thiomolybdates and bovine serum albumin, we have performed the syntheses and characterization of small model peptides such as His-Lys, Thr(Ac)-His-Lys and Thr-His-Lys.	Histidine	199-202	albumin	Homo sapiens	99-112
11325515-10	2001	We prepared a recombinant full-length oCav-1 protein in which six consecutive histidine residues were tagged at the end of its COOH-terminus and developed a [His]6-tagged oCav-1 "pull-down assay" for studying the association of eNOS with Cav-1.	Histidine	78-87	caveolin 1	Homo sapiens	39-44
11384046-0	2001	Milk composition responses to unilateral arterial infusion of complete and histidine-lacking amino acid mixtures to the mammary glands of cows.	Histidine	75-84	Weaning weight-maternal milk	Bos taurus	0-4
11336800-8	2001	Although we were able to demonstrate that [His(10)]-PTH(1-14) binds Zn(II) using (1)H-NMR, our spectroscopic studies (circular dichroism and nuclear magnetic resonance) were not consistent with the notion that zinc enhanced the activity of [His(10)]-PTH(1-14) simply by inducing a helical structure in the 10-14 region.	Histidine	43-46	parathyroid hormone	Rattus norvegicus	52-55
11336800-8	2001	Although we were able to demonstrate that [His(10)]-PTH(1-14) binds Zn(II) using (1)H-NMR, our spectroscopic studies (circular dichroism and nuclear magnetic resonance) were not consistent with the notion that zinc enhanced the activity of [His(10)]-PTH(1-14) simply by inducing a helical structure in the 10-14 region.	Histidine	241-244	parathyroid hormone	Rattus norvegicus	52-55
11336800-9	2001	Rather, the data suggest that the enhancement in cAMP potency arises from the formation of a ternary complex between [His(10)]-PTH(1-14), a zinc atom, and the extracellular loop/transmembrane domain region of the PTH-1 receptor.	Histidine	118-121	parathyroid hormone	Rattus norvegicus	127-130
11336800-3	2001	We found that substitution of histidine for the native asparagine at position 10 of PTH(1-14) provided a peptide that was approx.	Histidine	30-39	parathyroid hormone	Rattus norvegicus	84-87
11306246-2	2001	Relevant amino acids were selected according to a peptidic binding site model for PDE4 inhibitors, which suggests interaction with two tryptophan residues, one histidine and one tyrosine residue, as well as one Zn(2+) ion.	Histidine	160-169	phosphodiesterase 4A	Homo sapiens	82-86
11457012-9	2001	Distal histidine may serve as an electron-transfer pathway as it does in cytochrome c.	Histidine	7-16	cytochrome c, somatic	Homo sapiens	73-85
11345651-7	2001	RESULTS: The rate of bleaching of ADR by light-excited riboflavin was enhanced in the presence of histidine in a concentration-dependent manner.	Histidine	98-107	aldo-keto reductase family 1 member B	Homo sapiens	34-37
11345651-10	2001	RNO was found to block the histidine enhancement of the riboflavin-mediated photobleaching of ADR in a competitive manner.	Histidine	27-36	aldo-keto reductase family 1 member B	Homo sapiens	94-97
11345651-11	2001	Among the imidazole analogs of histidine tested, urocanic acid was found to be the most efficient enhancer of the riboflavin-mediated photobleaching of ADR.	Histidine	31-40	aldo-keto reductase family 1 member B	Homo sapiens	152-155
11345651-12	2001	Superoxide anion radicals which retard the oxidation of ADR were quenched by urocanic acid but not by histidine.	Histidine	102-111	aldo-keto reductase family 1 member B	Homo sapiens	56-59
11345651-13	2001	It was shown that the oxidation of ADR by the trans-annular peroxide of histidine resulted in the formation of 3-methoxysalicylic acid.	Histidine	72-81	aldo-keto reductase family 1 member B	Homo sapiens	35-38
11345651-14	2001	CONCLUSIONS: In contrast to singlet oxygen, the trans-annular peroxide, formed by the interaction of histidine and the singlet oxygen produced by photoexcited riboflavin, is an efficient oxidizer of ADR.	Histidine	101-110	aldo-keto reductase family 1 member B	Homo sapiens	199-202
11345651-15	2001	The enhancement of the riboflavin-mediated photobleaching of ADR by histidine analogs depends on the rate of their conversion to a trans-annular peroxide and on the efficiency of these products in oxidizing ADR.	Histidine	68-77	aldo-keto reductase family 1 member B	Homo sapiens	61-64
11345651-15	2001	The enhancement of the riboflavin-mediated photobleaching of ADR by histidine analogs depends on the rate of their conversion to a trans-annular peroxide and on the efficiency of these products in oxidizing ADR.	Histidine	68-77	aldo-keto reductase family 1 member B	Homo sapiens	207-210
11345651-18	2001	The finding that histidine also enhanced the degradation of ADR to 3-methoxysalicylic acid, suggests that the process of ADR oxidation by the trans-annular peroxides is similar to the direct oxidation of ADR by excited triplet riboflavin.	Histidine	17-26	aldo-keto reductase family 1 member B	Homo sapiens	60-63
11337906-0	2001	Characterization of an apolipoprotein E3 variant (Arg 145--&gt;His) associated with mild hypertriglyceridemia.	Histidine	63-66	apolipoprotein E	Homo sapiens	23-40
11264017-2	2001	The Cys(2)/His(2) zinc finger is a structural motif required for sequence-specific DNA binding and is present in zinc finger transcription factors (ZFP): Sp1, Egr-1, and TFIIIA.	Histidine	11-14	general transcription factor IIIA	Homo sapiens	170-176
11345651-18	2001	The finding that histidine also enhanced the degradation of ADR to 3-methoxysalicylic acid, suggests that the process of ADR oxidation by the trans-annular peroxides is similar to the direct oxidation of ADR by excited triplet riboflavin.	Histidine	17-26	aldo-keto reductase family 1 member B	Homo sapiens	121-124
11345651-18	2001	The finding that histidine also enhanced the degradation of ADR to 3-methoxysalicylic acid, suggests that the process of ADR oxidation by the trans-annular peroxides is similar to the direct oxidation of ADR by excited triplet riboflavin.	Histidine	17-26	aldo-keto reductase family 1 member B	Homo sapiens	121-124
11274462-2	2001	In this paper we show that amino acid substitutions at the fully exposed Lys15 in bovine pancreatic trypsin inhibitor (BPTI) influenced the CD- and DSC-monitored stability: The T(den) difference between the least (P1 Trp) and the most stable (P1 His) mutant is 11.2 degrees C at pH 2.0.	Histidine	246-249	trophoblast Kunitz domain protein 1	Bos taurus	100-117
11990614-3	2001	The recombinant DNA encoding human estrogen receptor ligand-binding domain was expressed in bacteria using the histidine-tag fusion system.	Histidine	111-120	estrogen receptor 1	Homo sapiens	35-52
11124949-2	2001	In the active site, which is homologous between the cis,syn-cyclobutane pyrimidine dimer and (6-4) photolyases, four amino acid residues that are specific to (6-4) photolyase, Gln(288), His(354), Leu(355), and His(358), and two conserved tryptophans, Trp(291) and Trp(398), were substituted with alanine.	Histidine	186-189	synemin S homeolog	Xenopus laevis	56-59
11124949-2	2001	In the active site, which is homologous between the cis,syn-cyclobutane pyrimidine dimer and (6-4) photolyases, four amino acid residues that are specific to (6-4) photolyase, Gln(288), His(354), Leu(355), and His(358), and two conserved tryptophans, Trp(291) and Trp(398), were substituted with alanine.	Histidine	210-213	synemin S homeolog	Xenopus laevis	56-59
11237766-2	2001	Asp-96 in MPO, a residue next to the histidine distal from the heme prosthetic group, has been assigned to the calcium-binding site of the enzyme by X-ray crystallography.	Histidine	37-46	myeloperoxidase	Homo sapiens	10-13
11096117-0	2001	A single histidine residue determines the pH sensitivity of the pacemaker channel HCN2.	Histidine	9-18	hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2	Homo sapiens	82-86
11270626-5	2001	The TEMPONE signal intensity was weakened significantly in the presence of beta-carotene and histidine in a concentration-dependent manner, but was not at all decreased by mannitol, Mn-superoxide dismutase and catalase.	Histidine	93-102	catalase	Homo sapiens	210-218
11112780-6	2001	But, in contrast to the human receptor, it also had high affinity for chicken GnRH ([Gln(8)]GnRH) and GnRH II ([His(5),Trp(7),Tyr(8)]GnRH) (K(i) 5.3 +/- 0.5 and 0.6 +/- 0.01 nM).	Histidine	112-115	mitochondrial ribosomal protein S26	Gallus gallus	102-109
11456876-3	2001	By contrast, the mechanism that involves intramolecular proton transfer in the enediolate was found to be energetically unfavorable due to electrostatic interactions with His 95, a conserved residue in TIM from different organisms.	Histidine	171-174	triosephosphate isomerase 1	Homo sapiens	202-205
11255107-5	2001	The levels of renal metallothionein-1 and metallothionein-2 mRNA in the rats fed the histidine-excess diet were higher or tended to be higher as compared with the rats fed the control (ad libitum and pair-fed) diet when fed for 1 or 3 days, respectively.	Histidine	85-94	metallothionein 1	Rattus norvegicus	20-37
11255107-2	2001	Therefore, this study was carried out to clarify whether excess dietary histidine alters the gene expressions of metallothionein-1 and metallothionein-2 in the liver and kidney.	Histidine	72-81	metallothionein 1	Rattus norvegicus	113-130
11255107-4	2001	The levels of liver metallothionein-1 and metallothionein-2 mRNA were markedly lower in the rats fed the histidine-excess diet as compared to those of the control (ad libitum and pair-fed) diet, when fed for 1 or 3 days.	Histidine	105-114	metallothionein 1	Rattus norvegicus	20-37
11243884-5	2001	When expressed in mammalian cells, the cloned human SN2 mediates Na(+)-coupled transport of system N-specific amino acid substrates (glutamine, asparagine, and histidine).	Histidine	160-169	solute carrier family 38 member 5	Homo sapiens	52-55
11243884-9	2001	The Michaelis-Menten constant for histidine uptake via human SN2 is 0.6 +/- 0.1 mM.	Histidine	34-43	solute carrier family 38 member 5	Homo sapiens	61-64
11238181-15	2001	In workers exposed to &gt;150 p.p.b., individuals with at least one polymorphic mEH His allele (His/His or His/Tyr genotypes) had a significant (P &lt; 0.001) 3-fold increase in Vf (mean Vf x 10(-6) +/- SE = 13.25 +/- 1.78) compared with individuals with the Tyr/Tyr genotype (mean Vf x 10(-6) +/- SE = 4.02 +/- 0.72).	Histidine	84-87	epoxide hydrolase 1, microsomal	Mus musculus	80-83
11238181-15	2001	In workers exposed to &gt;150 p.p.b., individuals with at least one polymorphic mEH His allele (His/His or His/Tyr genotypes) had a significant (P &lt; 0.001) 3-fold increase in Vf (mean Vf x 10(-6) +/- SE = 13.25 +/- 1.78) compared with individuals with the Tyr/Tyr genotype (mean Vf x 10(-6) +/- SE = 4.02 +/- 0.72).	Histidine	96-99	epoxide hydrolase 1, microsomal	Mus musculus	80-83
11157802-8	2001	Thus, the part of CBP encoding the RARA-binding domain, the CREB-binding domain, the three Cys/His-rich regions, the bromodomain, the HAT domain and the Glu-rich domains is present.	Histidine	95-98	CREB binding protein	Homo sapiens	18-21
11226423-5	2001	These results indicate that zinc binding to histatin 5 involves His-15 present within the -H-E-X-X-H- zinc binding motif, and copper binding occurs within the N-terminal D-S-H-, ATCUN motif.	Histidine	64-67	histatin 3	Homo sapiens	44-54
11067854-3	2001	Multiple sequence alignment was used to predict His(1089) as the catalytic residue in human ACE C-domain that, by analogy with the prototypical gluzincin, thermolysin, stabilizes the scissile carbonyl bond through a hydrogen bond during transition state binding.	Histidine	48-51	angiotensin I converting enzyme	Homo sapiens	92-95
11067854-8	2001	H1089A has a pH optimum of 5.5 with no pH dependence of its catalytic activity in the range 6.5-10.5, indicating that the His(1089) side chain allows ACE to function as an alkaline peptidyl-dipeptidase.	Histidine	122-125	angiotensin I converting enzyme	Homo sapiens	150-153
11067854-9	2001	Since transition state mutants of other gluzincins show pH optima shifts toward the alkaline, this effect of His(1089) on the ACE pH optimum and its ability to influence transition state binding of the sulfhydryl inhibitor captopril indicate that the catalytic mechanism of ACE is distinct from that of other gluzincins.	Histidine	109-112	angiotensin I converting enzyme	Homo sapiens	126-129
11067854-9	2001	Since transition state mutants of other gluzincins show pH optima shifts toward the alkaline, this effect of His(1089) on the ACE pH optimum and its ability to influence transition state binding of the sulfhydryl inhibitor captopril indicate that the catalytic mechanism of ACE is distinct from that of other gluzincins.	Histidine	109-112	angiotensin I converting enzyme	Homo sapiens	274-277
11563689-4	2001	In order to determine whether these conformational changes are consistent for other p53 mutants, we have now used molecular dynamics to determine the structure of the DNA-binding core domain of seven other environmentally induced, cancer-related p53 mutants, namely His 175, Asp 245, Asn 245, Trp 248, Met 249, Ser 278, and Lys 286.	Histidine	266-269	tumor protein p53	Homo sapiens	246-249
11368335-0	2001	Site-directed mutagenesis studies on a putative fifth iron ligand of mouse 8S-lipoxygenase: retention of catalytic activity on mutation of serine-558 to asparagine, histidine, or alanine.	Histidine	165-174	arachidonate 8-lipoxygenase	Mus musculus	75-90
11368335-2	2001	Mouse 8-LOX and its homologues (e.g., human 15-LOX-2) are unique in having a serine in place of the usual Asn or His in this fifth position.	Histidine	113-116	arachidonate 8-lipoxygenase	Mus musculus	6-11
11368335-2	2001	Mouse 8-LOX and its homologues (e.g., human 15-LOX-2) are unique in having a serine in place of the usual Asn or His in this fifth position.	Histidine	113-116	arachidonate 15-lipoxygenase type B	Homo sapiens	44-52
11327818-7	2001	The observation that dimeric LC8 dissociates at low pH can be explained by titration of a histidine pair in the dimer interface.	Histidine	90-99	cut up	Drosophila melanogaster	29-32
11311745-1	2001	The conserved core of melanocyte stimulating hormones (MSH), His-Phe-Arg-Trp, was probed by comparing a cyclic pentapeptide containing His-DPhe-Arg-Trp, with three structurally similar cyclic peptides, that lacked the His residue.	Histidine	61-65	proopiomelanocortin	Homo sapiens	22-53
11311745-1	2001	The conserved core of melanocyte stimulating hormones (MSH), His-Phe-Arg-Trp, was probed by comparing a cyclic pentapeptide containing His-DPhe-Arg-Trp, with three structurally similar cyclic peptides, that lacked the His residue.	Histidine	61-65	proopiomelanocortin	Homo sapiens	55-58
11311745-1	2001	The conserved core of melanocyte stimulating hormones (MSH), His-Phe-Arg-Trp, was probed by comparing a cyclic pentapeptide containing His-DPhe-Arg-Trp, with three structurally similar cyclic peptides, that lacked the His residue.	Histidine	135-139	proopiomelanocortin	Homo sapiens	22-53
11311745-1	2001	The conserved core of melanocyte stimulating hormones (MSH), His-Phe-Arg-Trp, was probed by comparing a cyclic pentapeptide containing His-DPhe-Arg-Trp, with three structurally similar cyclic peptides, that lacked the His residue.	Histidine	135-139	proopiomelanocortin	Homo sapiens	55-58
11311745-1	2001	The conserved core of melanocyte stimulating hormones (MSH), His-Phe-Arg-Trp, was probed by comparing a cyclic pentapeptide containing His-DPhe-Arg-Trp, with three structurally similar cyclic peptides, that lacked the His residue.	Histidine	61-64	proopiomelanocortin	Homo sapiens	22-53
11311745-1	2001	The conserved core of melanocyte stimulating hormones (MSH), His-Phe-Arg-Trp, was probed by comparing a cyclic pentapeptide containing His-DPhe-Arg-Trp, with three structurally similar cyclic peptides, that lacked the His residue.	Histidine	61-64	proopiomelanocortin	Homo sapiens	55-58
11311745-4	2001	The data indicate that the His residue of the small rigid cyclic MSH core peptides does not participate in binding with the melanocortin receptors.	Histidine	27-30	proopiomelanocortin	Homo sapiens	65-68
11182770-4	2001	Western blotting of whole-cell lysates and immunoprecipitates of membrane and cytosolic fractions of HEK 293 cells stably overexpressing a carboxy-terminal His-tagged GbetaL indicates that the protein is cytosolic and that it migrates at 42 kDa.	Histidine	156-159	MTOR associated protein, LST8 homolog	Homo sapiens	167-173
11273008-4	2001	The second glioblastoma also contained multiple, but different mutations: p53 mutations in codons 158 (CGC--&gt;CAC, Arg--&gt;His) and 273 (CGT--&gt;TGT, Arg--&gt;Cys), and a PTEN mutation in codon 233 (CGA--&gt;TGA, Arg--&gt;Stop).	Histidine	126-129	tumor protein p53	Homo sapiens	74-77
11289267-3	2001	Earlier experiments with this basal diet had shown that histidine was first-limiting for secretion of milk protein, followed by methionine and lysine.	Histidine	56-65	casein beta	Bos taurus	102-114
11289267-4	2001	The yield of milk protein was increased progressively with the amount of histidine infused.	Histidine	73-82	casein beta	Bos taurus	13-25
11289267-5	2001	The efficiency of transfer of histidine into milk protein was 0.42 for the 4H and 4HG and 0.35 for the 8H and 8HG treatments, and the concentration of milk protein was increased over Basal by all infusion treatments.	Histidine	30-39	casein beta	Bos taurus	45-57
11139392-8	2001	The deduced amino acid sequence of rat DPP II shared high similarity with quiescent-cell proline dipeptidase (78% identity) and prolyl carboxypeptidase (38% identity) and bore the putative catalytic triad (Ser, Asp, His) conserved in serine peptidase families.	Histidine	216-219	dipeptidylpeptidase 7	Rattus norvegicus	39-45
11713417-5	2001	The gene products of DNMT2 I and DNMT2 II differ by the inclusion of a histidine or tyrosine residue at the position specified by codon 101.	Histidine	71-80	tRNA aspartic acid methyltransferase 1	Homo sapiens	21-26
11341960-2	2001	Alignment of the amino acid sequences of FAE1 KCS, KCS1, and five other putative elongase condensing enzymes (KCSs) revealed the presence of six conserved cysteine and four conserved histidine residues.	Histidine	183-192	inositol polyphosphate kinase KCS1	Saccharomyces cerevisiae S288C	51-55
11163793-4	2001	However, the current loss in hKv1.5 was observed when the extracellular pH, pH(o), was reduced from 7.4 to 6.0, a behavior similar to that observed previously for current through mKv1.3 with a histidine at the equivalent position (H404).	Histidine	193-202	potassium voltage-gated channel subfamily A member 5	Homo sapiens	29-35
11163793-6	2001	Replacement of a histidine at position 463 in hKv1.5 by glycine confirmed this hypothesis making this H463G mutant channel sensitive to removal of [K(+)](o) even at pH(o) 7.4.	Histidine	17-26	potassium voltage-gated channel subfamily A member 5	Homo sapiens	46-52
11204225-1	2001	The qualitative separation performance of a C18, C8 and C4 reversed-phase column was investigated for the separation of histidine and its metabolites histamine, 1-methyihistamine and trans- and cis-urocanic acid.	Histidine	120-129	Bardet-Biedl syndrome 9	Homo sapiens	44-47
11732615-7	2001	The selection of a specific mRNA coding for a shortened FABP with a N-terminal His-tag via the accompanying protein property was shown.	Histidine	79-82	fatty acid binding protein 3	Bos taurus	56-60
11732615-8	2001	Goal of the selection was to bind the FABP via the His-tag on Ni(II)-IDA-agarose.	Histidine	51-54	fatty acid binding protein 3	Bos taurus	38-42
11713417-5	2001	The gene products of DNMT2 I and DNMT2 II differ by the inclusion of a histidine or tyrosine residue at the position specified by codon 101.	Histidine	71-80	tRNA aspartic acid methyltransferase 1	Homo sapiens	33-38
11554339-0	2001	Production and purification of histidine-tagged dihydrotestosterone-bound full-length human androgen receptor.	Histidine	31-40	androgen receptor	Homo sapiens	92-109
11115608-4	2001	NS1 bound to the two related cysteine-histidine-rich regions of CBP, referred to as C/H1 and C/H3, the former of which has an antagonistic function to CBP upon the NS1-transactivation.	Histidine	38-47	CREB binding protein	Homo sapiens	64-67
11115608-4	2001	NS1 bound to the two related cysteine-histidine-rich regions of CBP, referred to as C/H1 and C/H3, the former of which has an antagonistic function to CBP upon the NS1-transactivation.	Histidine	38-47	CREB binding protein	Homo sapiens	151-154
11210039-10	2001	For the leg, the uptake of His and Thr were decreased by insulin, whereas the infusion of AA stimulated the uptake of total essential AA.	Histidine	27-30	insulin	Capra hircus	57-64
11137123-2	2000	The cDNA of equine IL2 or IL4 was cloned in a mammalian expression vector, containing c-terminal myc- and six histidines His(6)-epitopes for recognition and purification of equine cytokines.	Histidine	110-120	interleukin 4	Equus caballus	26-29
11843266-0	2001	Relationship between plasma cyclo (His-Pro), a neuropeptide common to processed protein-rich food, and C-peptide/insulin molar ratio in obese women.	Histidine	35-38	insulin	Homo sapiens	103-112
21340840-7	2001	We have identified a missense mutation in the p53 gene in the 2774 ovarian cancer cell line that converts an arginine residue in the DNA binding region of the protein to a histidine residue (6).	Histidine	172-181	tumor protein p53	Homo sapiens	46-49
11158442-9	2001	Because several factors carrying the TCP domain have been implicated in the regulation of growth and development in lateral organs, the binding of TCP10 to this subset of AHPs suggests a possible linkage between the His-to-Asp phosphorelay systems and plant growth regulation.	Histidine	216-219	TCP domain protein 10	Arabidopsis thaliana	147-152
11097743-5	2000	Co-transfection of the p53 His(273)expression construct with a luciferase gene controlled by the p21(WAF1)promoter showed that the p53 His(273)was inactive, although TNF-alpha increased the transcriptional rate of p21(WAF1)in these cells.	Histidine	27-30	tumor protein p53	Homo sapiens	23-26
11171170-2	2000	As well, a recombinant histidine-tagged N-terminal fragment of BnDGAT1 [BnDGAT1((1-116))His(6)], which was relatively hydrophilic, was partially characterized.	Histidine	23-32	diacylglycerol O-acyltransferase 1-like	Brassica napus	63-70
11171170-2	2000	As well, a recombinant histidine-tagged N-terminal fragment of BnDGAT1 [BnDGAT1((1-116))His(6)], which was relatively hydrophilic, was partially characterized.	Histidine	23-32	diacylglycerol O-acyltransferase 1-like	Brassica napus	72-79
11171170-2	2000	As well, a recombinant histidine-tagged N-terminal fragment of BnDGAT1 [BnDGAT1((1-116))His(6)], which was relatively hydrophilic, was partially characterized.	Histidine	88-91	diacylglycerol O-acyltransferase 1-like	Brassica napus	63-70
11171170-2	2000	As well, a recombinant histidine-tagged N-terminal fragment of BnDGAT1 [BnDGAT1((1-116))His(6)], which was relatively hydrophilic, was partially characterized.	Histidine	88-91	diacylglycerol O-acyltransferase 1-like	Brassica napus	72-79
11171170-6	2000	The fragment BnDGAT1(1-116)His(6) interacted with [1-(14)C]oleoyl-CoA, suggesting that the N-terminal region of BnDGAT1 may have a role in binding cellular acyl-CoA.	Histidine	27-30	diacylglycerol O-acyltransferase 1-like	Brassica napus	13-20
11171170-6	2000	The fragment BnDGAT1(1-116)His(6) interacted with [1-(14)C]oleoyl-CoA, suggesting that the N-terminal region of BnDGAT1 may have a role in binding cellular acyl-CoA.	Histidine	27-30	diacylglycerol O-acyltransferase 1-like	Brassica napus	112-119
11097743-5	2000	Co-transfection of the p53 His(273)expression construct with a luciferase gene controlled by the p21(WAF1)promoter showed that the p53 His(273)was inactive, although TNF-alpha increased the transcriptional rate of p21(WAF1)in these cells.	Histidine	135-138	tumor protein p53	Homo sapiens	23-26
11097743-5	2000	Co-transfection of the p53 His(273)expression construct with a luciferase gene controlled by the p21(WAF1)promoter showed that the p53 His(273)was inactive, although TNF-alpha increased the transcriptional rate of p21(WAF1)in these cells.	Histidine	135-138	cyclin dependent kinase inhibitor 1A	Homo sapiens	97-100
11097743-5	2000	Co-transfection of the p53 His(273)expression construct with a luciferase gene controlled by the p21(WAF1)promoter showed that the p53 His(273)was inactive, although TNF-alpha increased the transcriptional rate of p21(WAF1)in these cells.	Histidine	27-30	tumor protein p53	Homo sapiens	131-134
11097743-5	2000	Co-transfection of the p53 His(273)expression construct with a luciferase gene controlled by the p21(WAF1)promoter showed that the p53 His(273)was inactive, although TNF-alpha increased the transcriptional rate of p21(WAF1)in these cells.	Histidine	135-138	tumor protein p53	Homo sapiens	131-134
11097743-5	2000	Co-transfection of the p53 His(273)expression construct with a luciferase gene controlled by the p21(WAF1)promoter showed that the p53 His(273)was inactive, although TNF-alpha increased the transcriptional rate of p21(WAF1)in these cells.	Histidine	135-138	tumor necrosis factor	Homo sapiens	166-175
11097743-5	2000	Co-transfection of the p53 His(273)expression construct with a luciferase gene controlled by the p21(WAF1)promoter showed that the p53 His(273)was inactive, although TNF-alpha increased the transcriptional rate of p21(WAF1)in these cells.	Histidine	135-138	cyclin dependent kinase inhibitor 1A	Homo sapiens	214-217
11097743-5	2000	Co-transfection of the p53 His(273)expression construct with a luciferase gene controlled by the p21(WAF1)promoter showed that the p53 His(273)was inactive, although TNF-alpha increased the transcriptional rate of p21(WAF1)in these cells.	Histidine	135-138	cyclin dependent kinase inhibitor 1A	Homo sapiens	218-222
11097743-5	2000	Co-transfection of the p53 His(273)expression construct with a luciferase gene controlled by the p21(WAF1)promoter showed that the p53 His(273)was inactive, although TNF-alpha increased the transcriptional rate of p21(WAF1)in these cells.	Histidine	27-30	tumor necrosis factor	Homo sapiens	166-175
11148286-4	2000	We used positional information to clone IAR1, which encodes a novel protein with seven predicted transmembrane domains and several His-rich regions.	Histidine	131-134	ZIP metal ion transporter family	Arabidopsis thaliana	40-44
11102465-3	2000	Intriguingly, an arginine-to-histidine mutation at the homologous position in the L-type Ca(2+) channel (R528H) is a common cause of HypoPP.	Histidine	29-38	calcium voltage-gated channel subunit alpha1 S	Homo sapiens	133-139
11062069-7	2000	Recombinant NSF-His(6) can also bind to C-terminal Rab6-glutathione S-transferase under the conditions to allow the ATP hydrolysis.	Histidine	16-19	N-ethylmaleimide sensitive factor, vesicle fusing ATPase	Rattus norvegicus	12-15
11062069-7	2000	Recombinant NSF-His(6) can also bind to C-terminal Rab6-glutathione S-transferase under the conditions to allow the ATP hydrolysis.	Histidine	16-19	RAB6A, member RAS oncogene family	Rattus norvegicus	51-55
11185553-5	2000	Bound rHRG was efficiently eluted from the affinity absorbent with 100 mM imidazole or histidine.	Histidine	87-96	histidine-rich glycoprotein	Rattus norvegicus	6-10
11086158-5	2000	Both homomer formation and binding of Cox2p are neither dependent on the presence of copper nor affected by mutations of His-239, Cys-148 or Cys-152.	Histidine	121-124	cytochrome c oxidase subunit 2	Saccharomyces cerevisiae S288C	38-43
11071875-1	2000	Microperoxidase 8 (MP8) is a heme octapeptide, obtained by enzymatic hydrolysis of heart cytochrome c, in which a histidine is axially coordinated to the heme iron, and acts as its fifth ligand.	Histidine	114-123	cytochrome c, somatic	Homo sapiens	89-101
11063596-1	2000	The alkaline conformational transition of a lysine 73 --&gt; histidine variant of iso-1-cytochrome c has been studied.	Histidine	61-70	cytochrome c, somatic	Homo sapiens	88-100
10958787-0	2000	Interactions of Cdk7 and Kin28 with Hint/PKCI-1 and Hnt1 histidine triad proteins.	Histidine	57-66	cyclin dependent kinase 7	Homo sapiens	16-20
10958787-0	2000	Interactions of Cdk7 and Kin28 with Hint/PKCI-1 and Hnt1 histidine triad proteins.	Histidine	57-66	adenosine 5'-monophosphoramidase	Saccharomyces cerevisiae S288C	52-56
10958787-2	2000	Here, we report a novel interaction between Cdk7 and a histidine triad (HIT) family protein, Hint/PKCI-1.	Histidine	55-64	cyclin dependent kinase 7	Homo sapiens	44-48
10958787-2	2000	Here, we report a novel interaction between Cdk7 and a histidine triad (HIT) family protein, Hint/PKCI-1.	Histidine	55-64	histidine triad nucleotide binding protein 1	Homo sapiens	93-97
10958787-2	2000	Here, we report a novel interaction between Cdk7 and a histidine triad (HIT) family protein, Hint/PKCI-1.	Histidine	55-64	histidine triad nucleotide binding protein 1	Homo sapiens	98-104
10958787-6	2000	The physical and genetic interactions of Hint and Hnt1 with Cdk7 and Kin28 suggest a role for this class of histidine triad proteins in the regulation of Cdk7 and Kin28 functions.	Histidine	108-117	histidine triad nucleotide binding protein 1	Homo sapiens	41-45
11029577-4	2000	Amyloid-beta peptide (Abeta) has a cluster of basic amino acids at the N-terminus (residues 13-16, His-His-Gln-Lys), which are considered critical for glycosaminoglycan interactions.	Histidine	99-102	amyloid beta precursor protein	Homo sapiens	22-27
10958787-6	2000	The physical and genetic interactions of Hint and Hnt1 with Cdk7 and Kin28 suggest a role for this class of histidine triad proteins in the regulation of Cdk7 and Kin28 functions.	Histidine	108-117	adenosine 5'-monophosphoramidase	Saccharomyces cerevisiae S288C	50-54
10958787-6	2000	The physical and genetic interactions of Hint and Hnt1 with Cdk7 and Kin28 suggest a role for this class of histidine triad proteins in the regulation of Cdk7 and Kin28 functions.	Histidine	108-117	cyclin dependent kinase 7	Homo sapiens	60-64
10958787-6	2000	The physical and genetic interactions of Hint and Hnt1 with Cdk7 and Kin28 suggest a role for this class of histidine triad proteins in the regulation of Cdk7 and Kin28 functions.	Histidine	108-117	cyclin dependent kinase 7	Homo sapiens	154-158
11029577-4	2000	Amyloid-beta peptide (Abeta) has a cluster of basic amino acids at the N-terminus (residues 13-16, His-His-Gln-Lys), which are considered critical for glycosaminoglycan interactions.	Histidine	103-106	amyloid beta precursor protein	Homo sapiens	22-27
11029577-8	2000	The results demonstrate that the His-His-Gln-Lys region of Abeta, and in particular His13, is an important structural domain, as Ala substitution produces a dysfunctional folding mutant.	Histidine	33-36	amyloid beta precursor protein	Homo sapiens	59-64
11029577-8	2000	The results demonstrate that the His-His-Gln-Lys region of Abeta, and in particular His13, is an important structural domain, as Ala substitution produces a dysfunctional folding mutant.	Histidine	37-40	amyloid beta precursor protein	Homo sapiens	59-64
11076860-8	2000	Kua proteins represent a novel class of conserved proteins with juxtamembrane histidine-rich motifs.	Histidine	78-87	plasmanylethanolamine desaturase 1	Homo sapiens	0-3
10938270-7	2000	Importantly, the inhibition of vWF secretion was rescued by depleting the cell extracts of the His-Rab4S22N with nickel beads.	Histidine	95-98	von Willebrand factor	Homo sapiens	31-34
11122377-6	2000	Two histidine-rich regions present in the mammalian selenoprotein P sequences are conserved in the zebrafish protein, and two SECIS elements are present in the 3" untranslated region.	Histidine	4-13	selenoprotein P	Homo sapiens	52-67
11186260-0	2000	Hb Nikaia [alpha20(B1)His-Asp]: a new variant of the alpha2 gene.	Histidine	22-25	glycoprotein hormone subunit alpha 2	Homo sapiens	11-17
11029602-7	2000	This mutation replaces a tyrosine by an histidine within the carboxyterminal globular domain of apM-1.	Histidine	40-49	adiponectin, C1Q and collagen domain containing	Homo sapiens	96-101
11041867-6	2000	In the light-minus-dark absorbance spectra, all mutations in PsaB exhibited an additional bleaching band at 665 nm at room temperature comparable with the published spectrum for the replacement of His(B656) with asparagine [Webber, A. N., Su Hui, Bingham, S. E., Kass, H., Krabben, L., Kuhn, M., Jordan, R., Schlodder, E., and Lubitz, W. (1996) Biochemistry 35, 12857-12863].	Histidine	197-200	fatty acid amide hydrolase	Homo sapiens	61-65
11015223-8	2000	Cyanoferric PGHS-1 exhibited a nu(Fe)(-)(CN) line at 446 cm(-1) and delta(Fe)(-)(C)(-)(N) at 410 cm(-1), indicating a "linear" Fe-C-N binding conformation with the proximal histidine.	Histidine	173-182	prostaglandin-endoperoxide synthase 1	Homo sapiens	12-18
11015223-13	2000	At alkaline pH, PGHS-1 is converted to a second CO binding conformation (nu(Fe)(-)(CO): 496 cm(-1)) where disruption of the hydrogen bonding interactions to the proximal histidine may occur.	Histidine	170-179	prostaglandin-endoperoxide synthase 1	Homo sapiens	16-22
11042688-2	2000	Although all cell lines contain the same p53 mutations at codons 175 (Arg--&gt;His) and 248 (Arg--&gt;Gln), the constitutive levels of p53 were progressively increased with the resistance of the cells to teniposide.	Histidine	79-82	tumor protein p53	Homo sapiens	135-138
10998365-7	2000	Both PDT-induced caspase-3 activation and PAK2 cleavage/activation can be inhibited by the singlet oxygen scavengers, L-histidine and alpha-tocopherol, but not the hydroxyl radical scavenger, mannitol, demonstrating that singlet oxygen is an immediate early-apoptotic signal generated by PDT.	Histidine	118-129	caspase 3	Homo sapiens	17-26
11012667-2	2000	Complete exchange was observed with histidine-tagged derivatives of LC17a, LC17b and E122A-LC17a (LC17a and LC17b are the usual constituants of smooth muscle myosin), with small changes in the ATPase activity of reconstituted myosins.	Histidine	36-45	myosin light chain 6	Homo sapiens	68-73
11012667-2	2000	Complete exchange was observed with histidine-tagged derivatives of LC17a, LC17b and E122A-LC17a (LC17a and LC17b are the usual constituants of smooth muscle myosin), with small changes in the ATPase activity of reconstituted myosins.	Histidine	36-45	myosin light chain 6	Homo sapiens	75-80
11012667-2	2000	Complete exchange was observed with histidine-tagged derivatives of LC17a, LC17b and E122A-LC17a (LC17a and LC17b are the usual constituants of smooth muscle myosin), with small changes in the ATPase activity of reconstituted myosins.	Histidine	36-45	myosin light chain 6	Homo sapiens	91-96
11012667-2	2000	Complete exchange was observed with histidine-tagged derivatives of LC17a, LC17b and E122A-LC17a (LC17a and LC17b are the usual constituants of smooth muscle myosin), with small changes in the ATPase activity of reconstituted myosins.	Histidine	36-45	myosin light chain 6	Homo sapiens	91-96
11012667-2	2000	Complete exchange was observed with histidine-tagged derivatives of LC17a, LC17b and E122A-LC17a (LC17a and LC17b are the usual constituants of smooth muscle myosin), with small changes in the ATPase activity of reconstituted myosins.	Histidine	36-45	myosin light chain 6	Homo sapiens	108-113
10875933-6	2000	The effect of CgA-(1-78) was blocked by anti-CgA antibodies against epitopes including residues Arg(53), His(54), and Leu(57).	Histidine	105-108	chromogranin A	Homo sapiens	14-17
11106177-5	2000	The two histidine residues (His12 and His119) in the active site of RNase A arise from two domains (S-peptide and S-protein) of the protein.	Histidine	8-17	ribonuclease pancreatic	Bos taurus	68-75
11085653-4	2000	Saturation transfer between methyls on adjacent pyrroles in etioheme-reconstituted horse Mb in all accessible oxidation/spin states reveals rotational hopping rates that decrease dramatically with either loss of ligands or reduction of the heme, and correlate qualitatively with expectations based on the Fe-His bond strength and the rate of heme dissociation from Mb.	Histidine	308-311	myoglobin	Equus caballus	89-91
11018721-2	2000	The murine Unp oncoprotein and its human homologue, Unph, both contain regions similar to the conserved Cys and His boxes common to all the Ubps.	Histidine	112-115	ubiquitin specific peptidase 4	Homo sapiens	52-56
10875933-6	2000	The effect of CgA-(1-78) was blocked by anti-CgA antibodies against epitopes including residues Arg(53), His(54), and Leu(57).	Histidine	105-108	chromogranin A	Homo sapiens	45-48
10970774-8	2000	Syncollin-His(6) became localized in ACTH-containing granules in the neuritic processes of AtT-20 cells.	Histidine	10-13	syncollin	Mus musculus	0-9
11024279-1	2000	Double FYVE-containing protein 1 (DFCP1) encodes a 777 amino acid protein that contains: (1) an N-terminal Cys-His cluster with some homology to many zinc finger domains; (2) a consensus sequence consistent with an ATP/GTP binding site; and (3) a C-terminal domain unique because it contains two zinc-binding FYVE domains.	Histidine	111-114	zinc finger FYVE-type containing 1	Homo sapiens	0-32
11024279-1	2000	Double FYVE-containing protein 1 (DFCP1) encodes a 777 amino acid protein that contains: (1) an N-terminal Cys-His cluster with some homology to many zinc finger domains; (2) a consensus sequence consistent with an ATP/GTP binding site; and (3) a C-terminal domain unique because it contains two zinc-binding FYVE domains.	Histidine	111-114	zinc finger FYVE-type containing 1	Homo sapiens	34-39
10970774-9	2000	In AR42J cells syncollin-His(6) did not co-localize with amylase, but was detected in acidic vesicles.	Histidine	25-28	syncollin	Rattus norvegicus	15-24
10970790-5	2000	The predicted amino acid sequence of the open reading frame had only 29% identity with the yeast ELO2 sequence, contained a single histidine-rich domain and had six transmembrane-spanning regions, as suggested by hydropathy analysis.	Histidine	131-140	fatty acid elongase ELO2	Saccharomyces cerevisiae S288C	97-101
10978146-6	2000	We show that the major component of PEG-IFN is pegylated in the imidazole side chain of histidine-34.	Histidine	88-97	interferon alpha 1	Homo sapiens	40-43
10978146-8	2000	This positional isomer, PEG-IFN(His-34), comprises approximately 47% of the total pegylated species when PEG-IFN is synthesized under the current experimental conditions at pH 6.5 with an electrophilic derivative of PEG, succinimidyl carbonate PEG.	Histidine	32-35	interferon alpha 1	Homo sapiens	28-31
10978146-8	2000	This positional isomer, PEG-IFN(His-34), comprises approximately 47% of the total pegylated species when PEG-IFN is synthesized under the current experimental conditions at pH 6.5 with an electrophilic derivative of PEG, succinimidyl carbonate PEG.	Histidine	32-35	interferon alpha 1	Homo sapiens	109-112
10969024-0	2000	Salt effects on ionization equilibria of histidines in myoglobin.	Histidine	41-51	myoglobin	Equus caballus	55-64
10978146-10	2000	The PEG-imidazole adduct in the intact protein, PEG-IFN(His-34), is labile but much more stable than in the peptide, PEG-IFN(His-34)dig.	Histidine	56-59	interferon alpha 1	Homo sapiens	52-55
10978146-10	2000	The PEG-imidazole adduct in the intact protein, PEG-IFN(His-34), is labile but much more stable than in the peptide, PEG-IFN(His-34)dig.	Histidine	125-128	interferon alpha 1	Homo sapiens	52-55
10978536-2	2000	The polypeptide encoded by GalNAc-T9 contained the structural features characteristic of GalNAc transferases, such as a GT1 motif, a Gal/GalNAc transferase motif, (QXW)(3) repeats, and conserved His, Cys, and acidic amino acid residues.	Histidine	195-198	polypeptide N-acetylgalactosaminyltransferase 9	Homo sapiens	27-36
11019858-0	2000	Histidine residues underlie Congo red binding to A beta analogs.	Histidine	0-9	amyloid beta precursor protein	Homo sapiens	49-55
11019858-11	2000	That histidine residues underlie CR binding in A beta amyloid is consistent with previous findings that A beta peptides sediment as fibrillar assemblies at pH-3-7 and bind Congo red over the same pH range in aqueous medium.	Histidine	5-14	amyloid beta precursor protein	Homo sapiens	47-53
11019858-11	2000	That histidine residues underlie CR binding in A beta amyloid is consistent with previous findings that A beta peptides sediment as fibrillar assemblies at pH-3-7 and bind Congo red over the same pH range in aqueous medium.	Histidine	5-14	amyloid beta precursor protein	Homo sapiens	104-110
11099853-3	2000	For achieving efficient purification of scFvs by immobilized metal-ion affinity chromatography (IMAC), a His-tag was placed either at the C-terminal (scFv-His6) or N-terminal (His6-scFv) of the coding sequence.	Histidine	105-108	immunglobulin heavy chain variable region	Homo sapiens	40-44
10969024-1	2000	The salt dependence of histidine pK(a) values in sperm whale and horse myoglobin and in histidine-containing peptides was measured by (1)H-NMR spectroscopy.	Histidine	23-32	myoglobin	Equus caballus	71-80
11099853-3	2000	For achieving efficient purification of scFvs by immobilized metal-ion affinity chromatography (IMAC), a His-tag was placed either at the C-terminal (scFv-His6) or N-terminal (His6-scFv) of the coding sequence.	Histidine	105-108	immunglobulin heavy chain variable region	Homo sapiens	150-154
11099853-4	2000	Solid-phase radioimmunoassay for scFv-His6 showed only 20-25% binding whereas both His6-scFv and scFv (no His-tag) showed 60-65% binding.	Histidine	38-41	immunglobulin heavy chain variable region	Homo sapiens	33-37
11099853-7	2000	Comparative homology modeling for scFv and scFv-His6 showed that the C-terminal position of the His-tag partially covered the antigen-binding site of the protein.	Histidine	48-51	immunglobulin heavy chain variable region	Homo sapiens	43-47
11099853-8	2000	The study demonstrates that the C-terminal position of His-tag on the CC49 scFv adversely affects the binding properties of the construct.	Histidine	55-58	immunglobulin heavy chain variable region	Homo sapiens	75-79
10969024-4	2000	In myoglobin two histidines (His(48) and His(36)) exhibited a shallower dependence than the average, and one (His(113)) showed a steeper dependence.	Histidine	17-27	myoglobin	Equus caballus	3-12
10969024-4	2000	In myoglobin two histidines (His(48) and His(36)) exhibited a shallower dependence than the average, and one (His(113)) showed a steeper dependence.	Histidine	29-32	myoglobin	Equus caballus	3-12
10969024-4	2000	In myoglobin two histidines (His(48) and His(36)) exhibited a shallower dependence than the average, and one (His(113)) showed a steeper dependence.	Histidine	41-44	myoglobin	Equus caballus	3-12
10969024-4	2000	In myoglobin two histidines (His(48) and His(36)) exhibited a shallower dependence than the average, and one (His(113)) showed a steeper dependence.	Histidine	41-44	myoglobin	Equus caballus	3-12
10801840-5	2000	Modeling of the three-dimensional structure of native VIP (central alpha-helice from Val(5) to Asn(24) with random coiled N and C terminus) and analogs shows that substitutions of His(1), Val(5), Arg(14), Lys(15), Lys(21), Leu(23), and Ile(26) decreased biological activity without altering the predicted structure, supporting that those residues directly interact with VPAC(1) receptor.	Histidine	180-183	vasoactive intestinal peptide	Homo sapiens	54-57
10945855-6	2000	The most pronounced effect was observed for p-fluorofentanyl, suggesting that an interaction between the 4-fluorophenylpropanamide moiety of the drug and residues Trp-318 and His-319 is important for the resulting enhanced GIRK1/GIRK2 channel activation through the mu-opioid receptor.	Histidine	175-178	potassium inwardly rectifying channel subfamily J member 6	Homo sapiens	229-234
10933792-1	2000	The histidines in the bisphosphatase domain of rat liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase were labeled with (15)N, both specifically at N1" and globally, for use in heteronuclear single quantum correlation (HSQC) NMR spectroscopic analyses.	Histidine	4-14	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	Rattus norvegicus	57-109
10801856-2	2000	We have solubilized and purified the histidine-tagged yeast secretory pathway/Golgi ion pump Pmr1 to near homogeneity in one step, using nickel affinity chromatography.	Histidine	37-46	Ca(2+)/Mn(2+)-transporting P-type ATPase PMR1	Saccharomyces cerevisiae S288C	93-97
10998179-3	2000	N-terminally histidine-tagged, wild-type FliI retarded untagged FliH in a Ni-NTA affinity chromatography assay, as did N-His-tagged versions of FliI carrying catalytic mutations.	Histidine	13-22	FLII actin remodeling protein	Homo sapiens	41-45
10933784-8	2000	The binding of His(6)-C2B and His(6)-(C2A+C2B) to InsP(n) surfaces did not show significant calcium dependence.	Histidine	30-33	secretoglobin family 2B member 3, pseudogene	Homo sapiens	42-45
10816586-4	2000	The results of mutating the 11 histidines in NEST suggest that NTE does not use a conventional catalytic triad.	Histidine	31-41	patatin like phospholipase domain containing 6	Homo sapiens	63-66
10924156-4	2000	This report shows that mutation of either His-607 (A motif) or His-643 (B motif) to alanine profoundly diminishes support of PDE catalysis by Mn(2+) or Mg(2+), but mutation of His-647 in B motif or of Glu in either motif does not.	Histidine	42-45	phosphodiesterase 5A	Homo sapiens	125-128
10924156-4	2000	This report shows that mutation of either His-607 (A motif) or His-643 (B motif) to alanine profoundly diminishes support of PDE catalysis by Mn(2+) or Mg(2+), but mutation of His-647 in B motif or of Glu in either motif does not.	Histidine	63-66	phosphodiesterase 5A	Homo sapiens	125-128
10924156-4	2000	This report shows that mutation of either His-607 (A motif) or His-643 (B motif) to alanine profoundly diminishes support of PDE catalysis by Mn(2+) or Mg(2+), but mutation of His-647 in B motif or of Glu in either motif does not.	Histidine	63-66	phosphodiesterase 5A	Homo sapiens	125-128
10881050-9	2000	ACE activity in BB was higher than in phosphate buffer (PB) due, at least in part, to a greater hydrolysis of the His-Leu product in PB.	Histidine	114-117	angiotensin I converting enzyme	Rattus norvegicus	0-3
10862049-5	2000	Two mutations in the CDKN2A (p16) gene were detected, including a novel base change AAC--&gt;ATC (Asn to Ile) at codon 71, that also changes the codon 85 of the alternative reading frame gene p14(ARF) from CAA to CAT (Gln to His).	Histidine	225-228	cyclin dependent kinase inhibitor 2A	Homo sapiens	21-27
10862049-5	2000	Two mutations in the CDKN2A (p16) gene were detected, including a novel base change AAC--&gt;ATC (Asn to Ile) at codon 71, that also changes the codon 85 of the alternative reading frame gene p14(ARF) from CAA to CAT (Gln to His).	Histidine	225-228	cyclin dependent kinase inhibitor 2A	Homo sapiens	29-32
10862049-5	2000	Two mutations in the CDKN2A (p16) gene were detected, including a novel base change AAC--&gt;ATC (Asn to Ile) at codon 71, that also changes the codon 85 of the alternative reading frame gene p14(ARF) from CAA to CAT (Gln to His).	Histidine	225-228	cyclin dependent kinase inhibitor 2A	Homo sapiens	192-195
10951531-1	2000	OBJECTIVE: To determine the relationship between two common apoA-IV variants (Thr347--&gt;Ser; Gln360--&gt;His), and body mass index (BMI) and percentage body fat.	Histidine	107-110	apolipoprotein A4	Homo sapiens	60-67
10913275-4	2000	In this study, covalent modification of CS2 by the affinity label N-bromoacetyl-L-arginine near His297, which is within the HRV signature of a His-2 motif, suggested this histidine could play a role in metal coordination.	Histidine	171-180	chorionic somatomammotropin hormone 2	Homo sapiens	40-43
10913275-4	2000	In this study, covalent modification of CS2 by the affinity label N-bromoacetyl-L-arginine near His297, which is within the HRV signature of a His-2 motif, suggested this histidine could play a role in metal coordination.	Histidine	171-180	histatin 3	Homo sapiens	143-148
10898952-3	2000	Despite the absence of ordered secondary structure, the peptide chain shields the heme group from solvent, as shown by (i) the pK(a) of protonation of the nonnative histidine ligand (5.18 +/- 0.05), lower than that of the bis-histidine guanidine-unfolded cytochrome c (5.58 +/- 0.05), and (ii) the redox potential, E(o) = 0 +/- 5 mV versus NHE, close to that of bis-histidine cytochrome c mutants but less negative than that of bis-histidine complexes of microperoxidase with short peptides.	Histidine	165-174	cytochrome c, somatic	Homo sapiens	255-267
10898952-3	2000	Despite the absence of ordered secondary structure, the peptide chain shields the heme group from solvent, as shown by (i) the pK(a) of protonation of the nonnative histidine ligand (5.18 +/- 0.05), lower than that of the bis-histidine guanidine-unfolded cytochrome c (5.58 +/- 0.05), and (ii) the redox potential, E(o) = 0 +/- 5 mV versus NHE, close to that of bis-histidine cytochrome c mutants but less negative than that of bis-histidine complexes of microperoxidase with short peptides.	Histidine	165-174	cytochrome c, somatic	Homo sapiens	376-388
10877846-3	2000	In this work, we show that an ade16 ade17 double disruption also leads to histidine auxotrophy, similar to the adenine/histidine auxotrophy of ade3 mutant yeast strains.	Histidine	74-83	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase ADE16	Saccharomyces cerevisiae S288C	30-35
10877846-3	2000	In this work, we show that an ade16 ade17 double disruption also leads to histidine auxotrophy, similar to the adenine/histidine auxotrophy of ade3 mutant yeast strains.	Histidine	119-128	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase ADE16	Saccharomyces cerevisiae S288C	30-35
10945231-4	2000	Bovine PC1 and PC2 contained the catalytic triad residues Asp, His, Ser, which are identical to the triads in PC1 and PC2 from other mammalian species.	Histidine	63-66	proprotein convertase subtilisin/kexin type 2	Bos taurus	15-18
10945231-4	2000	Bovine PC1 and PC2 contained the catalytic triad residues Asp, His, Ser, which are identical to the triads in PC1 and PC2 from other mammalian species.	Histidine	63-66	proprotein convertase subtilisin/kexin type 2	Bos taurus	118-121
10945231-4	2000	Bovine PC1 and PC2 contained the catalytic triad residues Asp, His, Ser, which are identical to the triads in PC1 and PC2 from other mammalian species.	Histidine	63-66	proprotein convertase subtilisin/kexin type 1	Bos taurus	7-10
10728833-10	2000	The amino-terminal sequence of LM-PLA2 (previously reported) indicates an aspartic acid residue located at position 49, together with other conserved amino acids present in the Asp-49 phospholipases, such as Tyr-28, Gly-30, Gly-32, His-48.	Histidine	232-235	phospholipase A2, group V	Mus musculus	34-38
10931311-1	2000	The histidine-containing phosphotransfer (HPt) protein YPD1 is an osmoregulatory protein in yeast that facilitates phosphoryl transfer between the two response regulator domains associated with SLN1 and SSK1.	Histidine	4-13	mitogen-activated protein kinase kinase kinase SSK1	Saccharomyces cerevisiae S288C	203-207
10728833-12	2000	Histidine alkylation with p-bromophenacyl bromide and lysine acetylation with acetic anhydride, abolished both indirect hemolytic and myotoxic activities of LM-PLA2.	Histidine	0-9	phospholipase A2, group V	Mus musculus	160-164
10841784-4	2000	The Raman spectra clearly demonstrate that three histidine residues in the N-terminal hydrophilic region provide primary metal binding sites and the solubility of the metal-Abeta complex is correlated with the metal binding mode.	Histidine	49-58	amyloid beta precursor protein	Homo sapiens	173-178
10777498-7	2000	Physical interactions between J-MTJ1 and BiP/GRP78 are stable and can be abolished by a single histidine --&gt; glutamine substitution in the highly conserved HPD motif shared by all DnaJ-like proteins.	Histidine	95-104	DnaJ heat shock protein family (Hsp40) member C1	Mus musculus	30-36
10777498-7	2000	Physical interactions between J-MTJ1 and BiP/GRP78 are stable and can be abolished by a single histidine --&gt; glutamine substitution in the highly conserved HPD motif shared by all DnaJ-like proteins.	Histidine	95-104	heat shock protein 5	Mus musculus	41-44
10777498-7	2000	Physical interactions between J-MTJ1 and BiP/GRP78 are stable and can be abolished by a single histidine --&gt; glutamine substitution in the highly conserved HPD motif shared by all DnaJ-like proteins.	Histidine	95-104	heat shock protein 5	Mus musculus	45-50
10843688-5	2000	A histidine-tagged form of porcine sB7-1 (sB7-1-His) interacted with both CD28 and CTLA-4, and effectively blocked IL-2 production from human responder cells stimulated with PHA and either porcine or human stimulator cells.	Histidine	2-11	interleukin 2	Homo sapiens	115-119
10841784-9	2000	Under normal physiological conditions, Cu(II) is expected to protect Abeta against Zn(II)-induced aggregation by competing with Zn(II) for histidine residues of Abeta.	Histidine	139-148	amyloid beta precursor protein	Homo sapiens	69-74
10841784-9	2000	Under normal physiological conditions, Cu(II) is expected to protect Abeta against Zn(II)-induced aggregation by competing with Zn(II) for histidine residues of Abeta.	Histidine	139-148	amyloid beta precursor protein	Homo sapiens	161-166
10875439-3	2000	Human amyloid derived Abeta has an increased content of arginine (46%) and glutamate/glutamine residues (28%), but a decreased content of histidine residues (-32%) as compared to the expected amino acid content.	Histidine	138-147	amyloid beta precursor protein	Homo sapiens	22-27
10854850-0	2000	Creatine kinase isoenzymes specificities: histidine 65 in human CK-BB, a role in protein stability, not in catalysis.	Histidine	42-51	creatine kinase B	Homo sapiens	64-69
11095118-1	2000	We examined the function of a highly conserved Histidine rich sequence of amino acids found in the carboxyl-terminal of the Na+/H+ exchanger (NHE1).	Histidine	47-56	solute carrier family 9 member A1	Homo sapiens	142-146
10875439-6	2000	Our results suggest that the loss of histidine residues in human amyloid-derived Abeta may be a result of Cu oxidation, and that unidentified post-translational mechanisms operate to modify other amino acids of Abeta in vivo.	Histidine	37-46	amyloid beta precursor protein	Homo sapiens	81-86
10747932-6	2000	These analyses identified a subset of cysteine and histidine residues required for stimulation of late gene expression, physical interaction with E1b 55k, and p53 destabilization.	Histidine	51-60	tumor protein p53	Homo sapiens	159-162
12483584-1	2000	A fusion protein of hexa-histidine repeat (His) and glycosylphosphatidylinositol (GPI)-anchor region of Saccharomyces cerevisiae Cwp1 with Aspergillus oryzae Taka-amylase A (TAA) was expressed on the yeast cell surface.	Histidine	43-46	Cwp1p	Saccharomyces cerevisiae S288C	129-133
12483584-2	2000	The expressed fusion protein (TAA-His-Cwp1) was localized on the cell wall and demonstrated amylolytic activity.	Histidine	34-37	Cwp1p	Saccharomyces cerevisiae S288C	38-42
10833385-5	2000	A recombinant baculovirus containing a 6x histidine-tagged PSMA gene was generated, from which rPSMA was expressed and purified using cobalt-chelating affinity chromatography.	Histidine	42-51	folate hydrolase 1	Homo sapiens	59-63
10748221-0	2000	The transactivation domain within cysteine/histidine-rich region 1 of CBP comprises two novel zinc-binding modules.	Histidine	43-52	CREB binding protein	Homo sapiens	70-73
10788426-3	2000	Two regions in the amino acid sequences of S100 proteins, namely the helices of the N-terminal EF-hand motif and the very C-terminal loop are believed to be involved in Zn(2+)-binding due to the presence of histidine and/or cysteine residues.	Histidine	207-216	S100 calcium binding protein A1	Homo sapiens	43-47
10748221-2	2000	Relatively little is known about the structure of CBP, but it has been noted that it contains three domains that are rich in cysteine and histidine (CH1, CH2, and CH3).	Histidine	138-147	CREB binding protein	Homo sapiens	50-53
10820014-0	2000	Substitution of tyrosine for the proximal histidine ligand to the heme of prostaglandin endoperoxide synthase 2: implications for the mechanism of cyclooxygenase activation and catalysis.	Histidine	42-51	prostaglandin-endoperoxide synthase 2	Homo sapiens	74-111
10799485-3	2000	Like yeast Ulp1, SUSP1 is a cysteine protease containing the well conserved His/Asp/Cys catalytic triad.	Histidine	76-79	SUMO specific peptidase 6	Homo sapiens	17-22
10864003-9	2000	Additional indirect structural information has been obtained by mutating a histidine in the predicted pore region of ICln.	Histidine	75-84	chloride nucleotide-sensitive channel 1A pseudogene 1	Homo sapiens	117-121
11272890-6	2000	All of the seven cases of fibrous dysplasia showed missense point mutations in Gsalpha at the Arg201 codon that resulted in Arg-to-His substitution in three cases and Arg-to-Cys substitution in four cases.	Histidine	131-134	GNAS complex locus	Homo sapiens	79-86
10749676-5	2000	The binding of (125)I-labelled TSP1 to these proteins was inhibited by peptides containing histidine residues, with the degree of competition being a function of the number of histidines within the peptide.	Histidine	91-100	thrombospondin 1	Homo sapiens	31-35
10772951-0	2000	Functional expression of four PDH-E(1)alpha recombinant histidine mutants in a human fibroblast cell line with zero endogenous PDH complex activity.	Histidine	56-65	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	30-33
10772951-1	2000	Conserved histidine residues have been implicated in the geometry and catalytic mechanism of the E(1)alpha proteins of the PDH complex.	Histidine	10-19	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	123-126
10772951-2	2000	We constructed and expressed a series of PDH-E(1)alpha histidine mutants (H63, H84, H92, and H263) in a cell line with zero PDH complex activity due to a null E(1)alpha allele.	Histidine	55-64	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	41-44
10772951-3	2000	Based on immunoblot and enzyme activity analyses, all introduced histidine mutations, with the exception of H92, affected the specific activity of the PDH complex.	Histidine	65-74	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	151-154
10749676-5	2000	The binding of (125)I-labelled TSP1 to these proteins was inhibited by peptides containing histidine residues, with the degree of competition being a function of the number of histidines within the peptide.	Histidine	176-186	thrombospondin 1	Homo sapiens	31-35
10749676-9	2000	Affinity chromatography with a polyhistidine-containing peptide immobilized on agarose revealed that TSP1 in platelet releasates is the major polypeptide retained on the six-histidine-peptide column.	Histidine	35-44	thrombospondin 1	Homo sapiens	101-105
10768184-2	2000	When the pattern of metal ions on a complex matches with the pattern of histidine moieties on the peptide, strong interaction (K = 1.2 x 10(6) M-1) can be achieved.	Histidine	72-81	myoregulin	Homo sapiens	143-146
10736180-6	2000	In addition, the structure of the carboxyl-terminus of immature and mature CFTR differed as histidine-tagged mature CFTR was preferentially recovered by metal-chelate chromatography.	Histidine	92-101	CF transmembrane conductance regulator	Homo sapiens	75-79
10736180-6	2000	In addition, the structure of the carboxyl-terminus of immature and mature CFTR differed as histidine-tagged mature CFTR was preferentially recovered by metal-chelate chromatography.	Histidine	92-101	CF transmembrane conductance regulator	Homo sapiens	116-120
10777659-3	2000	Putative expression clones were detected on the filters using an antibody against the N-terminal sequence RGS-His(6) of fusion proteins.	Histidine	110-113	paired like homeodomain 2	Homo sapiens	106-109
10892016-5	2000	Copper associated y fragment ions dominate the product ion spectrum for non-histidine containing peptides, but both b and y copper complex ions were observed for the histidine containing MHC class I associated peptide gp70.	Histidine	166-175	embigin	Homo sapiens	218-222
10733890-3	2000	The E. coli aas open reading frame was inserted into the expression plasmid pET28a so that, upon expression, a 21-amino-acid extension containing 6 consecutive histidine residues was added to the carboxyl terminus.	Histidine	160-169	FYVE, RhoGEF and PH domain containing 1	Homo sapiens	12-15
10708444-7	2000	Furthermore, using proteins expressed in Escherichia coli, a glutathione S-transferase-Nef fusion protein coprecipitated histidine-tagged portions of the TCR zeta cytoplasmic domain which contained SNID-1 or SNID-2.	Histidine	121-130	nef protein	Simian immunodeficiency virus	87-90
10819473-3	2000	The [C10H] variant of PfTFB was constructed to resemble the metal binding motif of higher eukaryal TFIIB proteins by mutating the second cysteine ligand to a histidine.	Histidine	158-167	general transcription factor IIB	Homo sapiens	99-104
10684817-1	2000	In the brain of all vertebrate classes, chicken (c) GnRH-II ([His(5), Trp(7),Tyr(8)]GnRH, cGnRH-II) is expressed in the mesencephalon.	Histidine	62-65	mitochondrial ribosomal protein S26	Gallus gallus	52-59
10692426-8	2000	Based on the histidine-rich nature of selenoprotein P, we have purified the recombinant and endogenously expressed proteins using nickel-agarose affinity chromatography.	Histidine	13-22	selenoprotein P	Homo sapiens	38-53
10692314-0	2000	Histidine(118) in the S2-S3 linker specifically controls activation of the KAT1 channel expressed in Xenopus oocytes.	Histidine	0-9	kynurenine aminotransferase 1 L homeolog	Xenopus laevis	75-79
10715115-8	2000	While His 19 of MGS and Lys 13 of TIM appear on the opposite face of the 2PG carboxylate plane, their relative location to the 2PG molecule is quite different, suggesting that they probably have different functions.	Histidine	6-9	triosephosphate isomerase 1	Homo sapiens	34-37
10683267-1	2000	We have used in vitro mutagenesis to introduce a six residue histidine sequence (His-tag) near the amino terminal end of the human PGHS-1 and -2 and have expressed these proteins using the baculovirus system.	Histidine	61-70	prostaglandin-endoperoxide synthase 1	Homo sapiens	131-144
10683267-1	2000	We have used in vitro mutagenesis to introduce a six residue histidine sequence (His-tag) near the amino terminal end of the human PGHS-1 and -2 and have expressed these proteins using the baculovirus system.	Histidine	81-84	prostaglandin-endoperoxide synthase 1	Homo sapiens	131-144
10712687-4	2000	We purified His-FLAG-tagged versions of: (i) export components FliH, FliI, FliJ, FlhAC and FlhBC; (ii) rod/hook-type export substrates FlgB (rod protein), FlgE (hook protein), FlgD (hook capping protein) and FliE (basal body protein); and (iii) filament-type export substrates FlgK and FlgL (hook-filament junction proteins) and FliC (flagellin).	Histidine	12-15	FLII actin remodeling protein	Homo sapiens	69-73
10803958-0	2000	Suppressive effect of excess dietary histidine on the expression of hepatic metallothionein-1 in rats.	Histidine	37-46	metallothionein 1	Rattus norvegicus	76-93
10803958-1	2000	The gene expression of liver metallothionein-1 in excess dietary histidine was investigated by feeding rats ad libitum on either a basal or histidine-excess (50 g of L-histidine per kg of diet) diet for 5 d. The copper content of the liver and zinc level in the serum of the rats fed on the histidine-excess diet were lower by 21% and 61%, respectively of the figures for the rats fed on the basal diet, but the zinc content of the liver and copper level in the serum were not affected.	Histidine	65-74	metallothionein 1	Rattus norvegicus	29-46
10803958-1	2000	The gene expression of liver metallothionein-1 in excess dietary histidine was investigated by feeding rats ad libitum on either a basal or histidine-excess (50 g of L-histidine per kg of diet) diet for 5 d. The copper content of the liver and zinc level in the serum of the rats fed on the histidine-excess diet were lower by 21% and 61%, respectively of the figures for the rats fed on the basal diet, but the zinc content of the liver and copper level in the serum were not affected.	Histidine	140-149	metallothionein 1	Rattus norvegicus	29-46
10803958-1	2000	The gene expression of liver metallothionein-1 in excess dietary histidine was investigated by feeding rats ad libitum on either a basal or histidine-excess (50 g of L-histidine per kg of diet) diet for 5 d. The copper content of the liver and zinc level in the serum of the rats fed on the histidine-excess diet were lower by 21% and 61%, respectively of the figures for the rats fed on the basal diet, but the zinc content of the liver and copper level in the serum were not affected.	Histidine	140-149	metallothionein 1	Rattus norvegicus	29-46
10803958-1	2000	The gene expression of liver metallothionein-1 in excess dietary histidine was investigated by feeding rats ad libitum on either a basal or histidine-excess (50 g of L-histidine per kg of diet) diet for 5 d. The copper content of the liver and zinc level in the serum of the rats fed on the histidine-excess diet were lower by 21% and 61%, respectively of the figures for the rats fed on the basal diet, but the zinc content of the liver and copper level in the serum were not affected.	Histidine	140-149	metallothionein 1	Rattus norvegicus	29-46
10666243-4	2000	A single difference at position 91, leucine in LAI and histidine in NDK, apparently accounted for their sensitivity or resistance to RPR103611.	Histidine	55-64	NME/NM23 nucleoside diphosphate kinase 4	Homo sapiens	68-71
10660557-2	2000	The classical cadherins contain an evolutionarily conserved His-Ala-Val (HAV) sequence, and linear peptides harboring this motif are capable of inhibiting a variety of cadherin-dependent processes.	Histidine	60-63	cadherin 1	Homo sapiens	14-22
10683321-5	2000	A two-amino-acid change, from 79-proline-glycine-80 to 79-histidine-arginine-80, confers on the human Cyclin T1 the ability to cooperate with eTat in transcriptional activation.	Histidine	58-67	cyclin T1	Homo sapiens	102-111
10684597-0	2000	Mutations at the histidine 249 ligand profoundly alter the spectral and iron-binding properties of human serum transferrin N-lobe.	Histidine	17-26	transferrin	Homo sapiens	111-122
10684598-3	2000	Possible explanations for the release of iron from transferrin at low pH include protonation of a histidine ligand and the existence of a pH-sensitive "trigger" involving a hydrogen-bonded pair of lysines in the N-lobe of transferrin.	Histidine	98-107	transferrin	Homo sapiens	51-62
15693279-9	2000	Finally, the A beta peptide derived from the human sequence has a greater effect than the A beta peptide derived from the rat sequence, suggesting that histidine 13 may play a role in copper reduction.	Histidine	152-161	amyloid beta precursor protein	Homo sapiens	13-19
10648402-2	2000	The vWf-binding site on GP Ib-IX-V is within the N-terminal 282 residues of GP Ibalpha, which consist of an N-terminal flanking sequence (His-1-Ile-35), 7 leucine-rich repeats (Leu-36-Ala-200), a C-terminal flank (Phe-201-Gly-268), and a sulfated tyrosine sequence (Asp-269-Glu-282).	Histidine	138-141	von Willebrand factor	Homo sapiens	4-7
10768836-3	2000	The scFv was fused to a human heavy chain IgG1 constant region (CH1-CH3) and contained an intact 6 His tag and enterokinase recognition site (RS10B5huFc).	Histidine	99-102	immunglobulin heavy chain variable region	Homo sapiens	4-8
10675363-4	2000	Because the single nucleotide polymorphism in FcgammaRIIA - which encodes histidine or arginine at position 131 - strongly influences IgG2 binding, we determined this polymorphism"s effect on CRP binding.	Histidine	74-83	C-reactive protein	Homo sapiens	192-195
10725552-5	2000	CfMV P1, P2a, P2b, and P3, containing a six histidine tag at the amino terminus, were expressed in Escherichia coli, purified and their RNA-binding activities were analysed.	Histidine	44-53	putative movement protein	Cocksfoot mottle virus	0-7
10651811-7	2000	Using these tools, it was demonstrated that the soluble His-tagged form of DnaJ protein exclusively binds the cytosolic isoform 1 of Hsp70.	Histidine	56-59	stromal 70 kDa heat shock-related protein, chloroplastic	Cucumis sativus	110-138
10625675-10	2000	Enzymes that react with substrate "head first" (5-LOX and 8-LOX) have a bulky aromatic amino acid and a histidine in these positions, whereas lipoxygenases that accept substrates "tail first" (12-LOX and 15-LOX) have an aliphatic residue with a glutamine or aspartate.	Histidine	104-113	arachidonate 5-lipoxygenase	Homo sapiens	48-53
10625675-10	2000	Enzymes that react with substrate "head first" (5-LOX and 8-LOX) have a bulky aromatic amino acid and a histidine in these positions, whereas lipoxygenases that accept substrates "tail first" (12-LOX and 15-LOX) have an aliphatic residue with a glutamine or aspartate.	Histidine	104-113	arachidonate 8-lipoxygenase	Mus musculus	58-63
10625675-10	2000	Enzymes that react with substrate "head first" (5-LOX and 8-LOX) have a bulky aromatic amino acid and a histidine in these positions, whereas lipoxygenases that accept substrates "tail first" (12-LOX and 15-LOX) have an aliphatic residue with a glutamine or aspartate.	Histidine	104-113	arachidonate 15-lipoxygenase	Homo sapiens	193-199
10722049-6	2000	rBip 1 Fabs with and without His-tag bound specifically to rBet v1 and, like Bet v1 -specific human serum IgE and rabbit-anti rBet v1 antibodies, cross-reacted with Bet v1-related allergens in other plant-species (alder, oak, hazelnut).	Histidine	29-32	putative DNA recombination protein Bet	Escherichia coli	60-63
15693279-9	2000	Finally, the A beta peptide derived from the human sequence has a greater effect than the A beta peptide derived from the rat sequence, suggesting that histidine 13 may play a role in copper reduction.	Histidine	152-161	amyloid beta precursor protein	Homo sapiens	90-96
10601317-11	1999	Considering the exterior location of His(73), this work indicates a surprisingly important role for the residue as a major structural determinant of actin and provides a clue to the impact caused by methylation of His(73).	Histidine	37-40	actin	Saccharomyces cerevisiae S288C	149-154
10773664-1	2000	We have identified a new human gene, FTCD, which maps to chromosome 21q22.3 and encodes the enzyme formiminotransferase cyclodeaminase, an intermediate metabolism enzyme that links histidine catabolism to folate metabolism.	Histidine	181-190	formimidoyltransferase cyclodeaminase	Homo sapiens	37-41
10773664-1	2000	We have identified a new human gene, FTCD, which maps to chromosome 21q22.3 and encodes the enzyme formiminotransferase cyclodeaminase, an intermediate metabolism enzyme that links histidine catabolism to folate metabolism.	Histidine	181-190	formimidoyltransferase cyclodeaminase	Homo sapiens	99-134
10718624-1	2000	The human selenoprotein W coding region with the selenocysteine codon (TGA) changed to a cysteine codon (TGT) was fused to six histidine codons (at its 3" end), cloned into a prokaryotic expression vector (pTrc99a), and the corresponding mutated selenoprotein W was expressed in bacteria.	Histidine	127-136	selenoprotein W	Homo sapiens	10-25
11006580-0	2000	Evaluation of the metal binding properties of the histidine-rich antimicrobial peptides histatin 3 and 5 by electrospray ionization mass spectrometry.	Histidine	50-59	histatin 3	Homo sapiens	88-98
10611285-8	1999	The data show that sGC acts as an extremely fast, specific, and highly efficient trap for NO and that cleavage of the iron-histidine bond provides the driving force for activation of sGC.	Histidine	123-132	sarcoglycan beta	Homo sapiens	19-22
10611285-8	1999	The data show that sGC acts as an extremely fast, specific, and highly efficient trap for NO and that cleavage of the iron-histidine bond provides the driving force for activation of sGC.	Histidine	123-132	sarcoglycan beta	Homo sapiens	183-186
10648963-4	1999	The recombinant Ra-eRF1 was marked with a histidine tag, overexpressed, and purified to homogeneity by two-step chromatography using Ni-NTA-agarose and Mono Q columns.	Histidine	42-51	eukaryotic peptide chain release factor subunit 1	Oryctolagus cuniculus	19-23
10648963-8	1999	The cloned Ra-eRF1 gene complemented a temperature-sensitive allele in the eRF1 gene, sup45 (ts), of S. cerevisiae, though the complementation activity was significantly impaired by the histidine tag, whereas Tt-eRF1 failed to complement the sup45 (ts) allele.	Histidine	186-195	eukaryotic peptide chain release factor subunit 1	Oryctolagus cuniculus	14-18
10567392-2	1999	Here, we report the purification of human recombinant COOH-terminal His-tagged sPLA(2)-X, the preparation of its antibody, and the purification of native sPLA(2)-X.	Histidine	68-71	phospholipase A2 group X	Homo sapiens	79-88
10570056-1	1999	A vasoactive intestinal polypeptide (VIP) analog, acylated on the amino-terminal histidine by hexanoic acid (C(6)-VIP), behaved as a VPAC(2) preferring agonist in binding and functional studies on human VIP receptors, and radioiodinated C(6)-VIP was a suitable ligand for binding studies on wild-type and chimeric receptors.	Histidine	81-90	vasoactive intestinal peptide	Homo sapiens	37-40
15822305-1	1999	Raman spectra of solid complexes RE(His)(NO3)3 x H2O (RE = La-Nd, Sm-Lu, Y; His = L-alpha-histidine ) have been investigated.	Histidine	36-39	NBL1, DAN family BMP antagonist	Homo sapiens	41-44
10641795-5	1999	We observed time-dependent losses of apoB histidine, lysine and glycine.	Histidine	42-51	apolipoprotein B	Homo sapiens	37-41
10567392-2	1999	Here, we report the purification of human recombinant COOH-terminal His-tagged sPLA(2)-X, the preparation of its antibody, and the purification of native sPLA(2)-X.	Histidine	68-71	phospholipase A2 group X	Homo sapiens	154-163
10690313-7	1999	RESULTS: Immunohistochemical stainings confirmed that gap junctions in the atrium and His-Purkinje system were composed of at least Cx43 and Cx40.	Histidine	86-89	gap junction protein, alpha 1	Rattus norvegicus	132-136
10548561-7	1999	Sequence comparison with mammalian EHs suggested that Asp(192), Asp(348) and His(374) constituted the catalytic triad of the fungal EH.	Histidine	77-80	epoxide hydrolase 1, microsomal	Mus musculus	35-37
10563822-5	1999	For the Tyr63Leu mutant, a new low-spin signal resembling that of alkaline cytochrome c (a His-heme-Lys species) is resolved, suggesting that the E10 lysine now coordinates to the heme.	Histidine	91-94	cytochrome c, somatic	Homo sapiens	75-87
10542213-5	1999	Deamidase and transglutaminase activities were blocked in the mutant proteins Cys(1292) --&gt; Ala, His(1307) --&gt; Ala, and Lys(1310) --&gt; Ala of DeltaDNT.	Histidine	100-103	cathepsin A	Homo sapiens	0-9
10690313-7	1999	RESULTS: Immunohistochemical stainings confirmed that gap junctions in the atrium and His-Purkinje system were composed of at least Cx43 and Cx40.	Histidine	86-89	gap junction protein, alpha 5	Rattus norvegicus	141-145
10531375-1	1999	The p53 tumor suppressor protein is a transcription factor that binds DNA in a sequence-specific manner through a protein domain stabilized by the coordination of zinc within a tetrahedral cluster of three cysteine residues and one histidine residue.	Histidine	232-241	tumor protein p53	Homo sapiens	4-7
10520211-2	1999	A genetic polymorphism in the apo A-IV gene, apo A-IV-2, encodes a His--&gt;Gln substitution at codon 360 that alters the biological function of this apolipoprotein.	Histidine	67-70	apolipoprotein A4	Homo sapiens	30-38
10520211-2	1999	A genetic polymorphism in the apo A-IV gene, apo A-IV-2, encodes a His--&gt;Gln substitution at codon 360 that alters the biological function of this apolipoprotein.	Histidine	67-70	apolipoprotein A4	Homo sapiens	45-53
10569723-1	1999	The present paper reports two new alpha-globin chain variants: Hb Boghe [alpha58(E7)His-->Gln, alpha2] and Hb Charolles [alpha103(G10)His-->Tyr, alpha1].	Histidine	134-137	BCL2 related protein A1	Homo sapiens	121-127
10569726-0	1999	Hb Toulon [alpha77(EF6)Pro-->His]: a new variant due to a mutation in the alpha2 gene found during measurement of glycated hemoglobin.	Histidine	29-32	glycoprotein hormone subunit alpha 2	Homo sapiens	74-80
10539772-0	1999	Histidine-imbalanced diets stimulate hepatic histidase gene expression in rats.	Histidine	0-9	histidine ammonia lyase	Rattus norvegicus	45-54
10539772-3	1999	The purpose of the present work was to study the effect of a histidine-imbalanced diet on the activity and mRNA concentration of rat hepatic histidase.	Histidine	61-70	histidine ammonia lyase	Rattus norvegicus	141-150
10539772-7	1999	Greater histidine imbalance resulted in lower food intake and higher Hal activity.	Histidine	8-17	histidine ammonia lyase	Rattus norvegicus	69-72
10539772-10	1999	These results indicate that rats fed a histidine-imbalanced diet exhibit reduced food intake and weight gain and increased Hal gene expression as a consequence of an increased amino acid catabolism.	Histidine	39-48	histidine ammonia lyase	Rattus norvegicus	123-126
10496983-5	1999	Our methodology for the analytical determination of 3-methylhistidine in actin offers an improved approach for investigating histidine methylation in proteins.	Histidine	60-69	actin	Saccharomyces cerevisiae S288C	73-78
10527513-2	1999	The usefulness of this method was demonstrated by analyzing two commercially available recombinant HIV proteins with affinity tags at the N-terminus, and histatin-5, a peptide with multiple histidine residues.	Histidine	190-199	histatin 3	Homo sapiens	154-164
10527516-4	1999	Presented is a continuous, coupled enzyme assay for TRH-DE in which TRH-DE hydrolyzed the substrate, pyroglutamyl-histidyl-prolylamido-4-methyl coumarin (TRHMCA), to give His-ProMCA, which was then cleaved by dipeptidyl peptidase IV (EC 3.4.14.5) to give 7-amino-4-methyl coumarin (MCA).	Histidine	171-174	thyrotropin releasing hormone degrading enzyme	Homo sapiens	52-58
10527516-4	1999	Presented is a continuous, coupled enzyme assay for TRH-DE in which TRH-DE hydrolyzed the substrate, pyroglutamyl-histidyl-prolylamido-4-methyl coumarin (TRHMCA), to give His-ProMCA, which was then cleaved by dipeptidyl peptidase IV (EC 3.4.14.5) to give 7-amino-4-methyl coumarin (MCA).	Histidine	171-174	thyrotropin releasing hormone degrading enzyme	Homo sapiens	68-74
10526251-9	1999	Direct sequencing of the albumin gene showed a guanine to adenosine transition in the second nucleotide of codon 218, resulting in a substitution of histidine (CAC) for the normal arginine (CGC) in one of the two alleles in the patient.	Histidine	149-158	albumin	Homo sapiens	25-32
10549857-2	1999	This single-chain Fv (scFv) with a histidine tag was expressed in Escherichia coli as an inclusion body.	Histidine	35-44	immunglobulin heavy chain variable region	Homo sapiens	22-26
10491433-4	1999	RESULTS: We identified a 3p14.2-specific YAC clone, located in the vicinity of the fragile histidine triad (FHIT) gene (but toward the telomere), that is capable of inducing sustained suppression of tumorigenicity in nude mice and of activating cellular senescence in vitro.	Histidine	91-100	fragile histidine triad gene	Mus musculus	108-112
10517856-0	1999	Histidine-41 of the cytochrome b5 domain of the borage delta6 fatty acid desaturase is essential for enzyme activity.	Histidine	0-9	fatty acid desaturase 2	Homo sapiens	55-83
10518318-4	1999	A novel missense mutation, which changes an arginine to a histidine in the RGG box region of FMRP in a typical fragile X patient, has been identified.	Histidine	58-67	fragile X messenger ribonucleoprotein 1	Homo sapiens	93-97
10464282-2	1999	Comparison of protein C activation in the presence and absence of TM identified 11 residues mediating the thrombin-TM interaction (Lys(21), Gln(24), Arg(62), Lys(65), His(66), Arg(68), Thr(69), Tyr(71), Arg(73), Lys(77), Lys(106)).	Histidine	167-170	coagulation factor II, thrombin	Homo sapiens	106-114
10473550-1	1999	Zinc increases the affinity of human growth hormone (hGH) for the human prolactin receptor (hPRLR) due to the coordination of one zinc ion involving Glu-174(hGH) and His-18(hGH).	Histidine	166-169	growth hormone 1	Homo sapiens	37-51
10508408-0	1999	Structural consequences of the B5 histidine --&gt; tyrosine mutation in human insulin characterized by X-ray crystallography and conformational analysis.	Histidine	34-43	insulin	Homo sapiens	78-85
10610126-5	1999	It was demonstrated for the first time that the receiver domain in this sensor exhibits a strong phosphohistidine phosphatase activity toward some Arabidopsis HPt phosphotransmitters (AHP1 and AHP2), suggesting the functional importance of the receiver domain for a resumed interaction of the sensor His-kinase with other His-Asp phosphorelay components.	Histidine	300-303	histidine-containing phosphotransmitter 2	Arabidopsis thaliana	193-197
10513557-2	1999	Both systemic capsaicin pretreatment and intravenous administration of CGRP receptor antagonist, human CGRP-(8-37), completely abolished the stimulatory effect of hepatic blood flow induced by intracisternal injection of TRH analog (RX-77368; p-Glu-His-(3,3"-dimethyl)-Pro-NH2, 100 ng), assessed by the hydrogen gas clearance method.	Histidine	249-252	calcitonin related polypeptide alpha	Homo sapiens	71-75
10513557-2	1999	Both systemic capsaicin pretreatment and intravenous administration of CGRP receptor antagonist, human CGRP-(8-37), completely abolished the stimulatory effect of hepatic blood flow induced by intracisternal injection of TRH analog (RX-77368; p-Glu-His-(3,3"-dimethyl)-Pro-NH2, 100 ng), assessed by the hydrogen gas clearance method.	Histidine	249-252	calcitonin related polypeptide alpha	Homo sapiens	103-107
10433686-10	1999	Interestingly, mutation of each of FAAH"s conserved histidines (H184, H358, and H449) generated active enzymes, indicating that FAAH does not contain a Ser-His-Asp catalytic triad commonly found in other mammalian serine hydrolytic enzymes.	Histidine	52-62	fatty acid amide hydrolase	Homo sapiens	35-39
10436051-7	1999	Ubiquitous expression of amontillado can restore near wild-type levels of this behavior, whereas expression of amontillado with an alanine substitution for the catalytic histidine cannot.	Histidine	170-179	amontillado	Drosophila melanogaster	111-122
10432318-5	1999	(1) His(111) is central to the conformational changes of PrP peptides.	Histidine	4-7	prion protein	Homo sapiens	57-60
10438490-0	1999	Evidence for a direct interaction between the penultimate aspartic acid of cholecystokinin and histidine 207, located in the second extracellular loop of the cholecystokinin B receptor.	Histidine	95-104	cholecystokinin B receptor	Homo sapiens	158-184
10438490-5	1999	To characterize the functional group in CCK that interacts with His(207), we first substituted His(207) to Ala.	Histidine	64-67	cholecystokinin	Homo sapiens	40-43
10438490-7	1999	The screening of L-alanine-modified CCK peptides to bind and activate the wild type and mutant receptors allowed the identification of the interaction of the C-terminal Asp(8) of CCK with His(207).	Histidine	188-191	cholecystokinin	Homo sapiens	36-39
10438490-7	1999	The screening of L-alanine-modified CCK peptides to bind and activate the wild type and mutant receptors allowed the identification of the interaction of the C-terminal Asp(8) of CCK with His(207).	Histidine	188-191	cholecystokinin	Homo sapiens	179-182
10433686-10	1999	Interestingly, mutation of each of FAAH"s conserved histidines (H184, H358, and H449) generated active enzymes, indicating that FAAH does not contain a Ser-His-Asp catalytic triad commonly found in other mammalian serine hydrolytic enzymes.	Histidine	52-62	fatty acid amide hydrolase	Homo sapiens	128-132
10423251-1	1999	Full-length histidine-tagged, dihydrotestosterone-bound human androgen receptor (AR) was purified to homogeneity by affinity and gel-filtration chromatography for antibody production and analysis of AR dimerization and DNA binding properties.	Histidine	12-21	androgen receptor	Homo sapiens	62-79
10419469-0	1999	Mutation of the five conserved histidines in the endothelial nitric-oxide synthase hemoprotein domain.	Histidine	31-41	nitric oxide synthase 3	Homo sapiens	49-82
10419469-2	1999	Five conserved histidine residues are found in the human endothelial nitric-oxide synthase (NOS) heme domain: His-420, His-421, and His-461 are close to the heme, whereas His-146 and His-214 are some distance away.	Histidine	15-24	nitric oxide synthase 3	Homo sapiens	57-90
10419469-2	1999	Five conserved histidine residues are found in the human endothelial nitric-oxide synthase (NOS) heme domain: His-420, His-421, and His-461 are close to the heme, whereas His-146 and His-214 are some distance away.	Histidine	110-113	nitric oxide synthase 3	Homo sapiens	57-90
10419469-2	1999	Five conserved histidine residues are found in the human endothelial nitric-oxide synthase (NOS) heme domain: His-420, His-421, and His-461 are close to the heme, whereas His-146 and His-214 are some distance away.	Histidine	119-122	nitric oxide synthase 3	Homo sapiens	57-90
10419469-2	1999	Five conserved histidine residues are found in the human endothelial nitric-oxide synthase (NOS) heme domain: His-420, His-421, and His-461 are close to the heme, whereas His-146 and His-214 are some distance away.	Histidine	119-122	nitric oxide synthase 3	Homo sapiens	57-90
10419469-2	1999	Five conserved histidine residues are found in the human endothelial nitric-oxide synthase (NOS) heme domain: His-420, His-421, and His-461 are close to the heme, whereas His-146 and His-214 are some distance away.	Histidine	119-122	nitric oxide synthase 3	Homo sapiens	57-90
10419469-2	1999	Five conserved histidine residues are found in the human endothelial nitric-oxide synthase (NOS) heme domain: His-420, His-421, and His-461 are close to the heme, whereas His-146 and His-214 are some distance away.	Histidine	119-122	nitric oxide synthase 3	Homo sapiens	57-90
10425452-8	1999	One potentially important deviation was noted: ovine BRS-3 possesses an arginine residue at position 294 instead of a histidine residue as found in all other BRS-3.	Histidine	118-127	bombesin receptor subtype-3	Ovis aries	53-58
10423251-1	1999	Full-length histidine-tagged, dihydrotestosterone-bound human androgen receptor (AR) was purified to homogeneity by affinity and gel-filtration chromatography for antibody production and analysis of AR dimerization and DNA binding properties.	Histidine	12-21	androgen receptor	Homo sapiens	81-83
10423251-1	1999	Full-length histidine-tagged, dihydrotestosterone-bound human androgen receptor (AR) was purified to homogeneity by affinity and gel-filtration chromatography for antibody production and analysis of AR dimerization and DNA binding properties.	Histidine	12-21	androgen receptor	Homo sapiens	199-201
10373475-2	1999	Thrombin exosite interactions with human factor V and its activation products were quantitatively characterized in equilibrium binding studies based on fluorescence changes of thrombin covalently labeled with 2-anilinonaphthalene-6-sulfonic acid (ANS) linked to the catalytic site histidine residue by Nalpha-[(acetylthio)acetyl]-D-Phe-Pro-Arg-CH2Cl ([ANS]FPR-thrombin).	Histidine	281-290	coagulation factor II, thrombin	Homo sapiens	0-8
10452554-2	1999	In spino-cerebellar ataxia type 1 (SCA1), histidine interruptions have been reported to mitigate the pathological effects of long glutamine stretches.	Histidine	42-51	ataxin 1	Homo sapiens	3-33
10452554-2	1999	In spino-cerebellar ataxia type 1 (SCA1), histidine interruptions have been reported to mitigate the pathological effects of long glutamine stretches.	Histidine	42-51	ataxin 1	Homo sapiens	35-39
10383406-12	1999	Biotin-maleimide modification of the mutant PSI complexes indicated that His-595, Trp-622, Leu-628, Tyr-632, and Asn-638 in wild-type PsaB may be exposed on the surface of the PSI complex.	Histidine	73-76	fatty acid amide hydrolase	Homo sapiens	134-138
10443012-7	1999	Using cytochrome c mutants and computer simulations of the native and mutated cytochromes, the source of this heterogeneity is found to originate from the His-33 residue motions.	Histidine	155-158	cytochrome c, somatic	Homo sapiens	6-18
10429510-6	1999	A single histidine or a (N alpha-His)-Ac group coupled to the N-terminus of the neurotensin fragments were used as a bidentate or a tridentate ligand respectively, which coordinate the metal carbonyl efficiently.	Histidine	9-18	neurotensin	Homo sapiens	80-91
10364230-1	1999	The productive folding pathway of cytochrome c passes through an obligatory HW intermediate in which the heme is coordinated by a solvent water molecule and a native ligand, His-18, prior to the formation of the folded HM state with both the native His-18 and Met-80 heme coordination.	Histidine	174-177	cytochrome c, somatic	Homo sapiens	34-46
10364230-1	1999	The productive folding pathway of cytochrome c passes through an obligatory HW intermediate in which the heme is coordinated by a solvent water molecule and a native ligand, His-18, prior to the formation of the folded HM state with both the native His-18 and Met-80 heme coordination.	Histidine	249-252	cytochrome c, somatic	Homo sapiens	34-46
10362647-6	1999	A histidine residue modifier, diethyl pyrocarbonate, inhibited glycylsarcosine uptake by both transporters, although the inhibitory effect was greater on PEPT1.	Histidine	2-11	solute carrier family 15 member 1	Homo sapiens	154-159
10229573-3	1999	A cloverleaf-like structure was observed between the genes for subunits 4 and 5 of NADH dehydrogenase (ND4 and -5), which is considered to have originated from histidine tRNA.	Histidine	160-169	ND4	Heterololigo bleekeri	103-113
10358054-3	1999	By substituting histidines for residues at the cytoplasmic ends of helices III and VI in retinal rhodopsin, we engineered a metal-binding site whose occupancy by Zn(II) prevented the receptor from activating a retinal G protein, Gt (Sheikh, S. P., Zvyaga, T. A. , Lichtarge, O., Sakmar, T. P., and Bourne, H. R. (1996) Nature 383, 347-350).	Histidine	16-26	rhodopsin	Homo sapiens	97-106
10365910-5	1999	The p16INK4a variants differ at amino acids 18 (histidine or proline) and 51 (valine or isoleucine), whereas the p19ARF variants differ only at amino acid 72 (histidine or arginine).	Histidine	159-168	cyclin dependent kinase inhibitor 2A	Mus musculus	113-119
10365910-8	1999	Functional analysis showed that the proline 18/isoleucine 51 p16INK4a variant was diminished in cdk6 binding, cdk6 inhibition and NIH/3T3 fibroblast growth suppression compared with the histidine 18/valine 51 variant, whereas both of the p19ARF variants suppressed growth with similar potencies.	Histidine	186-195	cyclin dependent kinase inhibitor 2A	Mus musculus	61-69
10383764-6	1999	Walker A sequence mutants directed repressor dimerization in E. coli and interacted with His-VirB4 in A. tumefaciens, indicating that ATP binding is not required for self-association.	Histidine	89-92	IncX type IV secretion system protein VirB4	Escherichia coli	93-98
10388847-0	1999	Catalytic role of the active site histidine of porcine pancreatic phospholipase A2 probed by the variants H48Q, H48N and H48K.	Histidine	34-43	phospholipase A2 group IB	Homo sapiens	66-82
10350644-6	1999	As expected, C/ATF was found to interact with three domains of CBP including CREB binding domain or kinase-inducible interaction (KIX) domain, the third cysteine-histidine-rich region (CH3 domain) and the nuclear receptor coactivator p160/SRC-1-interacting domain.	Histidine	162-171	activating transcription factor 4	Mus musculus	13-18
10329007-11	1999	A histidine repeat and a serine/threonine domain are present only in the largest form of the protein (MNBH-iso1).	Histidine	2-11	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	102-111
10229683-4	1999	Deoxyhypusine synthase was selectively retained by His.Tag-ec-eIF5A immobilized on a resin.	Histidine	51-54	deoxyhypusine synthase	Homo sapiens	0-22
10318773-5	1999	Using histidine-tagged recombinant TR6, we screened soluble forms of TNF-ligand proteins with immunoprecipitation.	Histidine	6-15	TNF receptor superfamily member 6b	Homo sapiens	35-38
10421457-1	1999	Recent evidence has been acquired that implicates an important role for several histidine residues in the hydrolytic mechanisms of human paraoxonase/arylesterase (PON1).	Histidine	80-89	paraoxonase 1	Homo sapiens	163-167
10421457-3	1999	Human PON1 treated with varying concentrations lost hydrolytic activity, and with each histidine modified, there was an exponential drop in hydrolytic activity.	Histidine	87-96	paraoxonase 1	Homo sapiens	6-10
10421457-8	1999	Mutants of PON1 containing an asparagine substituted for each of several conserved histidine residues lost hydrolytic activity for each single substitution.	Histidine	83-92	paraoxonase 1	Homo sapiens	11-15
10421457-11	1999	These two pieces of evidence implicate an important role for several histidine residues in the hydrolytic mechanism of PON1.	Histidine	69-78	paraoxonase 1	Homo sapiens	119-123
10421440-4	1999	Group-specific labelling studies, performed on the purified native enzyme, indicated that one or more Trp, His and Asp/Glu are potentially important residues for PON activity.	Histidine	107-110	paraoxonase 1	Homo sapiens	162-165
10367953-3	1999	Recombinant ova-LHRH proteins were over-expressed in E. coli strain BL21 (DE3) using a pET expression system, which expresses a target protein with a C-terminal His-Tag.	Histidine	161-164	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	12-15
10220559-8	1999	A histidine residue in the third extracellular loop of Kv1.5 (H452) accounts for the difference in pH sensitivity between the Kv1.5 and Kv1.2 channels.	Histidine	2-11	potassium channel, voltage gated shaker related subfamily A, member 2 L homeolog	Xenopus laevis	136-141
10395065-1	1999	To purify the androgen receptor (AR) efficiently from baculovirus expression system, we fused 6 histidine residues with the N-terminal domain of AR as a tag to specifically bind to Ni+2-affinity column.	Histidine	96-105	androgen receptor	Homo sapiens	14-31
10395065-1	1999	To purify the androgen receptor (AR) efficiently from baculovirus expression system, we fused 6 histidine residues with the N-terminal domain of AR as a tag to specifically bind to Ni+2-affinity column.	Histidine	96-105	androgen receptor	Homo sapiens	33-35
10395065-2	1999	Our data indicated that adding androgen can increase the binding capacity of his-tag AR to the Ni+2-affinity column, and this increased binding capacity of AR could be due to the exposure of histidine residues of N-terminal domain induced by androgen.	Histidine	77-80	androgen receptor	Homo sapiens	85-87
10395065-2	1999	Our data indicated that adding androgen can increase the binding capacity of his-tag AR to the Ni+2-affinity column, and this increased binding capacity of AR could be due to the exposure of histidine residues of N-terminal domain induced by androgen.	Histidine	77-80	androgen receptor	Homo sapiens	156-158
10395065-2	1999	Our data indicated that adding androgen can increase the binding capacity of his-tag AR to the Ni+2-affinity column, and this increased binding capacity of AR could be due to the exposure of histidine residues of N-terminal domain induced by androgen.	Histidine	191-200	androgen receptor	Homo sapiens	85-87
10395065-2	1999	Our data indicated that adding androgen can increase the binding capacity of his-tag AR to the Ni+2-affinity column, and this increased binding capacity of AR could be due to the exposure of histidine residues of N-terminal domain induced by androgen.	Histidine	191-200	androgen receptor	Homo sapiens	156-158
10206968-4	1999	In both channels, KST1 and KAT1, aspartate mutants in the K+ channel consensus sequence GYGD adjacent to the histidine (KST1-D269N and KAT1-D265N) were inhibited by a rise in the extracellular proton concentration.	Histidine	109-118	kynurenine aminotransferase 1	Homo sapiens	27-31
10206968-4	1999	In both channels, KST1 and KAT1, aspartate mutants in the K+ channel consensus sequence GYGD adjacent to the histidine (KST1-D269N and KAT1-D265N) were inhibited by a rise in the extracellular proton concentration.	Histidine	109-118	kynurenine aminotransferase 1	Homo sapiens	135-139
10206968-7	1999	From our electrophysiological studies on channel mutants with respect to the pore histidine as well as the aspartate, we conclude that the common proton-supported shift in the voltage dependence of KST1 and KAT1 is based on distinct molecular elements.	Histidine	82-91	kynurenine aminotransferase 1	Homo sapiens	207-211
10194369-0	1999	The roles of Glu-327 and His-446 in the bisphosphatase reaction of rat liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase probed by NMR spectroscopic and mutational analyses of the enzyme in the transient phosphohistidine intermediate complex.	Histidine	25-28	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	Rattus norvegicus	77-129
10213617-7	1999	In a mutant P-gp (E875C) that gave about equal amounts of both topologies, only the C-Half (CL3-cyt) could be recovered by nickel chromatography after coexpression with the histidine-tagged N-Half P-gp.	Histidine	173-182	ATP binding cassette subfamily B member 1	Homo sapiens	12-16
10213617-7	1999	In a mutant P-gp (E875C) that gave about equal amounts of both topologies, only the C-Half (CL3-cyt) could be recovered by nickel chromatography after coexpression with the histidine-tagged N-Half P-gp.	Histidine	173-182	ATP binding cassette subfamily B member 1	Homo sapiens	197-201
10194369-1	1999	The bisphosphatase domain derived from the rat liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase was studied by 1H-13C HMQC NMR spectroscopy of the histidine C2" and H2" nuclei.	Histidine	157-166	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	Rattus norvegicus	53-105
10077595-0	1999	Histidine-tagged wild-type yeast actin: its properties and use in an approach for obtaining yeast actin mutants.	Histidine	0-9	actin	Saccharomyces cerevisiae S288C	33-38
10077595-0	1999	Histidine-tagged wild-type yeast actin: its properties and use in an approach for obtaining yeast actin mutants.	Histidine	0-9	actin	Saccharomyces cerevisiae S288C	98-103
10052992-3	1999	Our results indicate that the linkage was formed between the side chain of a protamine arginine and a histidine in the insulin B chain, resulting in a net mass change of -5 Da, compared to the sum of the protamine and insulin molecular masses.	Histidine	102-111	insulin	Homo sapiens	119-126
10049337-0	1999	His ... Asp catalytic dyad of ribonuclease A: histidine pKa values in the wild-type, D121N, and D121A enzymes.	Histidine	46-55	ribonuclease pancreatic	Bos taurus	30-44
10049337-1	1999	Bovine pancreatic ribonuclease A (RNase A) has a conserved His ... Asp catalytic dyad in its active site.	Histidine	59-62	ribonuclease pancreatic	Bos taurus	18-32
10049337-1	1999	Bovine pancreatic ribonuclease A (RNase A) has a conserved His ... Asp catalytic dyad in its active site.	Histidine	59-62	ribonuclease pancreatic	Bos taurus	34-41
10049337-10	1999	Together, the data indicate that the aspartate residue in the His ... Asp catalytic dyad of RNase A has a measurable but modest effect on the ionization of the adjacent histidine residue.	Histidine	62-65	ribonuclease pancreatic	Bos taurus	92-99
10049337-10	1999	Together, the data indicate that the aspartate residue in the His ... Asp catalytic dyad of RNase A has a measurable but modest effect on the ionization of the adjacent histidine residue.	Histidine	169-178	ribonuclease pancreatic	Bos taurus	92-99
10347796-10	1999	There was a significant increase (P &lt; 0.05) of ACE activity in the right ventricle (6.9 +/- 0.9 to 8.2 +/- 0.6 nmol His-Leu g-1 min-1) and in the left ventricle (6.4 +/- 1.1 to 8.9 +/- 0.8 nmol His-Leu g-1 min-1).	Histidine	119-122	angiotensin I converting enzyme	Rattus norvegicus	50-53
10347796-10	1999	There was a significant increase (P &lt; 0.05) of ACE activity in the right ventricle (6.9 +/- 0.9 to 8.2 +/- 0.6 nmol His-Leu g-1 min-1) and in the left ventricle (6.4 +/- 1.1 to 8.9 +/- 0.8 nmol His-Leu g-1 min-1).	Histidine	197-200	angiotensin I converting enzyme	Rattus norvegicus	50-53
10347796-11	1999	In the aorta, however, ACE activity decreased (P &lt; 0.01) after isoproterenol (41 +/- 3 to 27 +/- 2 nmol His-Leu g-1 min-1) while it remained unchanged in the plasma.	Histidine	107-110	angiotensin I converting enzyme	Rattus norvegicus	23-26
10052953-10	1999	Twelve amino acids among conserved His and Asp/Glu residues were found essential for PON1 arylesterase and organophosphatase activities: H114, H133, H154, H242, H284, D53, D168, D182, D268, D278, E52, and E194.	Histidine	35-38	paraoxonase 1	Homo sapiens	85-89
10052992-3	1999	Our results indicate that the linkage was formed between the side chain of a protamine arginine and a histidine in the insulin B chain, resulting in a net mass change of -5 Da, compared to the sum of the protamine and insulin molecular masses.	Histidine	102-111	insulin	Homo sapiens	218-225
9930979-9	1999	The functions of His107 of hGSTM1a-1a are unexpected in view of a substantial body of previous evidence that excluded participation of histidine residues in the catalytic mechanisms of other glutathione S-transferases.	Histidine	135-144	glutathione S-transferase mu 1	Homo sapiens	27-37
10029083-5	1999	We screened the amino acid sequence of the MCSP molecule for a region of homology to the consensus sequence and found that the amino acid sequence Val-His-Ile-Asn-Ala-His spanning positions 289 and 294 has high homology.	Histidine	151-154	chondroitin sulfate proteoglycan 4	Homo sapiens	43-47
9973256-3	1999	We show that CREB binding protein (CBP), through two cysteine-histidine rich domains (C/H1 and C/H3), specifically and constitutively interacts with Pit-1 in pituitary cells.	Histidine	62-71	CREB binding protein	Homo sapiens	13-33
9973256-3	1999	We show that CREB binding protein (CBP), through two cysteine-histidine rich domains (C/H1 and C/H3), specifically and constitutively interacts with Pit-1 in pituitary cells.	Histidine	62-71	CREB binding protein	Homo sapiens	35-38
9973256-3	1999	We show that CREB binding protein (CBP), through two cysteine-histidine rich domains (C/H1 and C/H3), specifically and constitutively interacts with Pit-1 in pituitary cells.	Histidine	62-71	POU class 1 homeobox 1	Homo sapiens	149-154
10022850-5	1999	Zta bound directly to two related cysteine- and histidine-rich domains of CBP, referred to as C/H1 and C/H3.	Histidine	48-57	CREB binding protein	Homo sapiens	74-77
9880332-8	1999	Transgenic flies that express Act88F with either a 6x histidine tag or an 11-residue peptide derived from vesicular stomatitis virus G protein at the C terminus were flightless.	Histidine	54-63	Actin 88F	Drosophila melanogaster	30-36
9888808-0	1999	Role of His-224 in the anomalous pH dependence of human stromelysin-1.	Histidine	8-11	matrix metallopeptidase 3	Homo sapiens	56-69
9888808-4	1999	HS is the only known MMP that has a histidine in this position.	Histidine	36-45	matrix metallopeptidase 3	Homo sapiens	21-24
9987819-10	1999	Polyclonal antisera raised against histidine-tagged p12 protein expressed in bacteria reacted specifically with the p12 polypeptide in Western blots of CsPDV virions.	Histidine	35-44	DNA polymerase epsilon 4, accessory subunit	Homo sapiens	52-55
9987819-10	1999	Polyclonal antisera raised against histidine-tagged p12 protein expressed in bacteria reacted specifically with the p12 polypeptide in Western blots of CsPDV virions.	Histidine	35-44	DNA polymerase epsilon 4, accessory subunit	Homo sapiens	116-119
9882542-4	1999	Similarly, the sturgeon tachykinin (Ser-Lys-Tyr-His-Gln-Phe-Tyr-Gly-Leu-Met.NH2) contains only one amino acid substitution (Tyr3 --&gt; Ser) compared with scyliorhinin I previously isolated from bowfin stomach but five amino acid substitutions compared with trout substance P.	Histidine	48-51	tachykinin precursor 1	Homo sapiens	264-275
10320932-4	1999	Moreover, upon release into the environment, the E-cadherin fragments may interfere with intact complexes, as indicated by experiments with His-Ala-Val (HAV)-containing peptides that are homologous to parts of the first extracellular domain of E-cadherin.	Histidine	140-143	cadherin 1	Homo sapiens	49-59
9914503-3	1999	Tyr and Val residues are preferred at P3 by all cysteine proteinases whatever their origin, whereas only cruzipain and cathepsin L cleaved substrate with a His at that position.	Histidine	156-159	cathepsin L	Homo sapiens	119-130
9914503-4	1999	The combination of a Pro at P2 and His at P3 abolished cleavage by cathepsin L, so that only cruzipain was able to cleave the HPGGP peptide at the GG bond.	Histidine	35-38	cathepsin L	Homo sapiens	67-78
9890644-10	1999	The former sites may be primarily histidine residues of apolipoprotein B-100 that are oxidized to 2-oxo-histidine in the presence of Cu and AA or DHA, thus explaining, at least in part, the unusual inhibitory effect of vitamin C on Cu-induced LDL oxidation.	Histidine	34-43	apolipoprotein B	Homo sapiens	56-76
12136211-4	1999	By immobilized metal (Ni(2+)) chelation affinity chromatography up to 80% His(6)-hNMT was purified by one step from bacterial lysate.	Histidine	74-77	N-myristoyltransferase 1	Homo sapiens	81-85
9826434-2	1998	Previous studies from our laboratory suggested that the human platelet PDE3A active site has two essential histidine residues and one cysteine residue.	Histidine	107-116	phosphodiesterase 3A	Homo sapiens	71-76
9922138-6	1998	Our analysis uncovers several statistically significant residue clusters, including a cysteine-histidine-tyrosine cluster overlapping the CuA-Mg complex; a histidine-acidic cluster enveloping the environment of Mg, the two hemes, and CuB; and on the protein surface a mixed charge cluster, which may help stabilize the quaternary structure and/or mediate docking to cytochrome c.	Histidine	95-104	cytochrome c, somatic	Homo sapiens	366-378
9826434-3	1998	We therefore decided to begin mutating histidines and cysteines in the conserved domain of PDE3A.	Histidine	39-49	phosphodiesterase 3A	Homo sapiens	91-96
9894810-4	1998	The three-dimensional positions of these residues match those of corresponding histidines at the active center of human PCD.	Histidine	79-89	pterin-4 alpha-carbinolamine dehydratase 1	Homo sapiens	120-123
9813131-4	1998	In the context of 4E insulin, the employed mutants, i.e. ThrA8--&gt;His and ValA3--&gt;Gly, result in species with 143% and 0.1% biological activity, respectively, relative to human insulin.	Histidine	68-71	insulin	Homo sapiens	21-28
9853614-2	1998	Human formyl peptide receptor like-1 (FPRL-1) receptor, originally identified as an orphan G protein-coupled receptor related to the formyl peptide receptor (FPR1), was expressed in Saccharomyces cells designed to couple receptor activation to histidine prototrophy.	Histidine	244-253	formyl peptide receptor 1	Homo sapiens	158-162
9813131-4	1998	In the context of 4E insulin, the employed mutants, i.e. ThrA8--&gt;His and ValA3--&gt;Gly, result in species with 143% and 0.1% biological activity, respectively, relative to human insulin.	Histidine	68-71	insulin	Homo sapiens	182-189
9843453-1	1998	Triosephosphate isomerase (TIM) catalyzes the reversible interconversion of dihydroxyacetone phosphate (DHAP) and glyceraldehyde 3-phosphate (GAP), with Glu-165 removing the pro-R proton from C1 of DHAP and neutral His-95 polarizing the carbonyl group of the substrate.	Histidine	215-218	triosephosphate isomerase 1	Homo sapiens	0-25
9843453-1	1998	Triosephosphate isomerase (TIM) catalyzes the reversible interconversion of dihydroxyacetone phosphate (DHAP) and glyceraldehyde 3-phosphate (GAP), with Glu-165 removing the pro-R proton from C1 of DHAP and neutral His-95 polarizing the carbonyl group of the substrate.	Histidine	215-218	triosephosphate isomerase 1	Homo sapiens	27-30
9822599-4	1998	By contrast, the first EH domain of End3p preferentially binds peptides containing an His-Thr/Ser-Phe (HT/SF) motif.	Histidine	86-89	End3p	Saccharomyces cerevisiae S288C	36-41
9774399-0	1998	Mutation at histidine 338 of gp91(phox) depletes FAD and affects expression of cytochrome b558 of the human NADPH oxidase.	Histidine	12-21	CD33 molecule	Homo sapiens	34-38
9835437-6	1998	A missense mutation replacing arginine at amino acid position 186 by histidine (R186H) was identified in the PHKA2 gene.	Histidine	69-78	phosphorylase kinase regulatory subunit alpha 2	Homo sapiens	109-114
9881601-6	1998	To prevent the action of bacterial endogenous proteases and/or thrombin, which cleaves the protein into two fragments at an Arg-Ala trypsin-sensitive site in positions 168-169, we have introduced a single mutation (Arg168--&gt;His), thus making the whole domain more stable and suitable for crystallization.	Histidine	227-230	coagulation factor II	Mus musculus	63-71
10068041-4	1998	Inspection of the structure of the complex suggested that it might be possible to convert the scFv into a bond-specific protease by the introduction of three catalytic residues: a glutamate to increase the nucleophilicity of a nearby water molecule, a lysine to increase the polarizability of the carbonyl group and a histidine to provide a proton to convert the amine into a better leaving group.	Histidine	318-327	immunglobulin heavy chain variable region	Homo sapiens	94-98
9786917-3	1998	We report here that CBP, which was originally identified as a co-activator of CREB, directly binds to the b-ZIP region of ATF-2 via a Cys/His-rich region termed C/H2, and potentiates trans-activation by ATF-2.	Histidine	138-141	CREB binding protein	Homo sapiens	20-23
9778369-0	1998	Effects of L-histidine and its structural analogues on human N-myristoyltransferase activity and importance of EEVEH amino acid sequence for enzyme activity.	Histidine	11-22	N-myristoyltransferase 1	Homo sapiens	61-83
9792715-10	1998	The presence of 4 +/- 0.4 microM GST-DHPR II-III or 5 +/- 0.1 microM His-peptide-DHPR III-IV was required for half-maximal co-purification of 35S-labeled RyR1 Leu922-Asp1112 on glutathione-Sepharose or Ni2+-nitrilotriacetic acid.	Histidine	69-72	quinoid dihydropteridine reductase	Homo sapiens	81-85
9812373-4	1998	The ACR2 gene was cloned and expressed in Escherichia coli as a malE gene fusion with a C-terminal histidine tag.	Histidine	99-108	Arr2p	Saccharomyces cerevisiae S288C	4-8
9822821-4	1998	The same combined approach, used to study histidine biosynthesis gene expression, showed that HIS1 and HIS4 expression is co-regulated with purine biosynthesis genes whereas HIS2, HIS3, HIS5 and HIS6 expression is not.	Histidine	42-51	trifunctional histidinol dehydrogenase/phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase	Saccharomyces cerevisiae S288C	103-107
9845266-1	1998	The melanocortins form a family of pro-opiomelanocortin-derived peptides that have the melanocyte-stimulating hormone (MSH) core sequence, His-Phe-Arg-Trp, in common.	Histidine	139-142	proopiomelanocortin	Homo sapiens	87-117
9778377-0	1998	Galactose mutarotase: purification, characterization, and investigations of two important histidine residues.	Histidine	90-99	galactose mutarotase	Homo sapiens	0-20
9778369-2	1998	Human NMT (hNMT) activity was found to be activated by L-histidine in a concentration-dependent manner.	Histidine	55-66	N-myristoyltransferase 1	Homo sapiens	6-9
9778369-2	1998	Human NMT (hNMT) activity was found to be activated by L-histidine in a concentration-dependent manner.	Histidine	55-66	N-myristoyltransferase 1	Homo sapiens	11-15
9778369-3	1998	In contrast, two structural analogues of L-histidine, L-histidinol and histamine, inhibited hNMT activity in a noncompetitive manner with half-maximal inhibitions of 18 and 1.5 mM, respectively.	Histidine	41-52	N-myristoyltransferase 1	Homo sapiens	92-96
9804162-2	1998	Putative proteins (ATHP1-3) contain an HPt (Histidine-containing Phospho transfer)-like domain with a conserved histidine and some invariant residues that are involved in phosphorelay.	Histidine	44-53	histidine-containing phosphotransmitter 3	Arabidopsis thaliana	19-26
9778369-4	1998	The inhibition of hNMT activity by L-histidinol was reversed by a 2-fold molar excess of L-histidine, suggesting that L-histidine and L-histidinol were competing for a common site on NMT.	Histidine	89-100	N-myristoyltransferase 1	Homo sapiens	18-22
9778369-4	1998	The inhibition of hNMT activity by L-histidinol was reversed by a 2-fold molar excess of L-histidine, suggesting that L-histidine and L-histidinol were competing for a common site on NMT.	Histidine	89-100	N-myristoyltransferase 1	Homo sapiens	19-22
9778369-4	1998	The inhibition of hNMT activity by L-histidinol was reversed by a 2-fold molar excess of L-histidine, suggesting that L-histidine and L-histidinol were competing for a common site on NMT.	Histidine	118-129	N-myristoyltransferase 1	Homo sapiens	18-22
9778369-4	1998	The inhibition of hNMT activity by L-histidinol was reversed by a 2-fold molar excess of L-histidine, suggesting that L-histidine and L-histidinol were competing for a common site on NMT.	Histidine	118-129	N-myristoyltransferase 1	Homo sapiens	19-22
9804162-2	1998	Putative proteins (ATHP1-3) contain an HPt (Histidine-containing Phospho transfer)-like domain with a conserved histidine and some invariant residues that are involved in phosphorelay.	Histidine	112-121	histidine-containing phosphotransmitter 3	Arabidopsis thaliana	19-26
9699465-4	1998	Additional energy calculations for designed cyclic analogues were used for further refinement of the model for the biologically active conformations of the His-Phe-Arg-Trp "message" sequence within the sequences of alpha-MSH and [D-Phe7]alpha-MSH.	Histidine	156-159	proopiomelanocortin	Homo sapiens	215-224
9770345-8	1998	In contrast to these findings, parallel studies with a polyclonal antibody to FHIT, a related histidine triad (HIT) protein and putative tumor suppressor, indicated that FHIT was expressed at low or undetectable levels in some of the same cell lines.	Histidine	94-103	fragile histidine triad gene	Mus musculus	78-82
9770345-8	1998	In contrast to these findings, parallel studies with a polyclonal antibody to FHIT, a related histidine triad (HIT) protein and putative tumor suppressor, indicated that FHIT was expressed at low or undetectable levels in some of the same cell lines.	Histidine	94-103	fragile histidine triad gene	Mus musculus	170-174
9839011-3	1998	Of the three residues (Tyr 48, His 110, and Trp 111) that can form hydrogen bonds with the ionized portion of aldose reductase inhibitors, protonated His110 appears to play an important role in directing charged inhibitors to bind at the active site through charge interaction.	Histidine	31-34	aldo-keto reductase family 1 member B	Homo sapiens	110-126
9801458-4	1998	The amino acid sequences of insulins from R. catesbeiana and R. ridibunda differ by only one residue (Asp for Glu at B21) but R. sylvatica insulin differs from R. catesbeiana insulin at A12 (Thr--&gt;Met), A23 (Asn--&gt;Ser), B5 (Tyr--&gt;His) and B13 (Glu--&gt;Asp).	Histidine	239-242	insulin	Homo sapiens	28-35
9699465-4	1998	Additional energy calculations for designed cyclic analogues were used for further refinement of the model for the biologically active conformations of the His-Phe-Arg-Trp "message" sequence within the sequences of alpha-MSH and [D-Phe7]alpha-MSH.	Histidine	156-159	proopiomelanocortin	Homo sapiens	237-246
9698371-1	1998	Three conserved histidines have been shown to be important for the enzymatic activity of 4a-hydroxy-tetrahydropterin dehydratase, a bifunctional enzyme which is involved in regeneration of tetrahydrobiopterin and is also a cofactor (DCoH) for the transcription factor HNF-1alpha.	Histidine	16-26	HNF1 homeobox A	Homo sapiens	268-278
9733547-1	1998	Phosphoribosyl-ATP pyrophosphohydrolase (PRA-PH) and phosphoribosyl-AMP cyclohydrolase (PRA-CH) are encoded by HIS4 in yeast and by hisIE in bacteria and catalyze the second and the third step, respectively, in the histidine biosynthetic pathway.	Histidine	215-224	trifunctional histidinol dehydrogenase/phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase	Saccharomyces cerevisiae S288C	111-115
9790785-8	1998	Exons 2 through 11 of the p53 gene were analyzed by direct DNA sequencing, revealing a homozygous mutation at codon 281 in exon 8, GAC to CAC (Asp--&gt;His).	Histidine	152-155	tumor protein p53	Homo sapiens	26-29
9698371-0	1998	Stereospecificity and catalytic function of histidine residues in 4a-hydroxy-tetrahydropterin dehydratase/DCoH.	Histidine	44-53	pterin-4 alpha-carbinolamine dehydratase 1	Homo sapiens	106-110
9689058-9	1998	These results suggest that the enzymes in the PLD superfamily use the conserved histidine for nucleophilic attack on the substrate phosphorus atom and most likely proceed via a common two-step catalytic mechanism.	Histidine	80-89	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	46-49
9698371-1	1998	Three conserved histidines have been shown to be important for the enzymatic activity of 4a-hydroxy-tetrahydropterin dehydratase, a bifunctional enzyme which is involved in regeneration of tetrahydrobiopterin and is also a cofactor (DCoH) for the transcription factor HNF-1alpha.	Histidine	16-26	pterin-4 alpha-carbinolamine dehydratase 1	Homo sapiens	233-237
9754717-0	1998	Critical role of conserved histidine pairs HNXXH and HDXXH in recombinant human phosphodiesterase 4A.	Histidine	27-36	phosphodiesterase 4A	Homo sapiens	80-100
9688907-5	1998	Two contiguous peptides from D5 in the histidine-glycine-rich region, Gly442-Lys458 and Phe459-Lys478, each inhibit the binding of HK to PMN.	Histidine	39-48	kininogen 1	Homo sapiens	131-133
9681494-3	1998	Bufo insulin was, however, more potent (4-fold) than human insulin in inhibiting the binding of [125I-Tyr-A14] insulin to the soluble full-length recombinant human insulin receptor, which is probably a consequence of the substitution (Thr --&gt; His) at position A-8.	Histidine	246-249	insulin	Homo sapiens	5-12
9681494-3	1998	Bufo insulin was, however, more potent (4-fold) than human insulin in inhibiting the binding of [125I-Tyr-A14] insulin to the soluble full-length recombinant human insulin receptor, which is probably a consequence of the substitution (Thr --&gt; His) at position A-8.	Histidine	246-249	insulin	Homo sapiens	59-66
9681494-3	1998	Bufo insulin was, however, more potent (4-fold) than human insulin in inhibiting the binding of [125I-Tyr-A14] insulin to the soluble full-length recombinant human insulin receptor, which is probably a consequence of the substitution (Thr --&gt; His) at position A-8.	Histidine	246-249	insulin	Homo sapiens	59-66
9888526-9	1998	A point mutant of StAR (A218V) that causes lipoid congenital adrenal hyperplasia was incorporated into the His-tag protein.	Histidine	107-110	steroidogenic acute regulatory protein	Bos taurus	18-22
9642211-5	1998	Upon reconstitution into proteoliposomes, histidine-tagged purified P-gp from baculovirus-infected insect cells had drug-stimulated ATPase activity.	Histidine	42-51	ATP binding cassette subfamily B member 1	Homo sapiens	68-72
9706704-1	1998	Procedures have been devised for producing in Escherichia coli high yields of purified recombinant human growth hormone (hGH), by utilizing N-terminal pentapeptide sequence of human tumor necrosis factor-alpha, histidine tag and enterokinase cleavage site as a fusion partner.	Histidine	211-220	growth hormone 1	Homo sapiens	105-119
9618168-9	1998	This mutation is a G-->A transition altering an arginine residue to a histidine in a highly conserved location in the second helix of the homeobox of RIEG1.	Histidine	70-79	paired like homeodomain 2	Homo sapiens	150-155
9658205-7	1998	We have investigated the molecular basis for differential inhibition of EAAT1 and EAAT2 by Zn2+ using site-directed mutagenesis and demonstrate that histidine residues of EAAT1 at positions 146 and 156 form part of the Zn2+ binding site.	Histidine	149-158	solute carrier family 1 member 3	Homo sapiens	72-77
9658205-7	1998	We have investigated the molecular basis for differential inhibition of EAAT1 and EAAT2 by Zn2+ using site-directed mutagenesis and demonstrate that histidine residues of EAAT1 at positions 146 and 156 form part of the Zn2+ binding site.	Histidine	149-158	solute carrier family 1 member 2	Homo sapiens	82-87
9658205-7	1998	We have investigated the molecular basis for differential inhibition of EAAT1 and EAAT2 by Zn2+ using site-directed mutagenesis and demonstrate that histidine residues of EAAT1 at positions 146 and 156 form part of the Zn2+ binding site.	Histidine	149-158	solute carrier family 1 member 3	Homo sapiens	171-176
9658205-8	1998	EAAT2 contains a histidine residue at the position corresponding to histidine 146 of EAAT1, but at the position corresponding to histidine 156 of EAAT1, EAAT2 has a glycine residue.	Histidine	17-26	solute carrier family 1 member 2	Homo sapiens	0-5
9658205-8	1998	EAAT2 contains a histidine residue at the position corresponding to histidine 146 of EAAT1, but at the position corresponding to histidine 156 of EAAT1, EAAT2 has a glycine residue.	Histidine	17-26	solute carrier family 1 member 3	Homo sapiens	85-90
9658205-8	1998	EAAT2 contains a histidine residue at the position corresponding to histidine 146 of EAAT1, but at the position corresponding to histidine 156 of EAAT1, EAAT2 has a glycine residue.	Histidine	68-77	solute carrier family 1 member 2	Homo sapiens	0-5
9658205-8	1998	EAAT2 contains a histidine residue at the position corresponding to histidine 146 of EAAT1, but at the position corresponding to histidine 156 of EAAT1, EAAT2 has a glycine residue.	Histidine	68-77	solute carrier family 1 member 3	Homo sapiens	85-90
9658205-8	1998	EAAT2 contains a histidine residue at the position corresponding to histidine 146 of EAAT1, but at the position corresponding to histidine 156 of EAAT1, EAAT2 has a glycine residue.	Histidine	68-77	solute carrier family 1 member 2	Homo sapiens	0-5
9658205-8	1998	EAAT2 contains a histidine residue at the position corresponding to histidine 146 of EAAT1, but at the position corresponding to histidine 156 of EAAT1, EAAT2 has a glycine residue.	Histidine	68-77	solute carrier family 1 member 3	Homo sapiens	85-90
9658205-9	1998	Mutation of this glycine residue in EAAT2 to histidine generates a Zn2+ sensitive transporter, further confirming the role of this residue in conferring differential Zn2+ sensitivity.	Histidine	45-54	solute carrier family 1 member 2	Homo sapiens	36-41
9632696-13	1998	A point mutant of StAR (A218V) that causes lipoid congenital adrenal hyperplasia was incorporated into the His-tag protein.	Histidine	107-110	steroidogenic acute regulatory protein	Bos taurus	18-22
9633603-7	1998	A histidine-tagged form of Idh1p was expressed in yeast strains.	Histidine	2-11	isocitrate dehydrogenase (NAD(+)) IDH1	Saccharomyces cerevisiae S288C	27-32
9688280-7	1998	The heme structure in SDS-unfolded cytochrome c, as deduced from heme absorption and resonance Raman spectra, shows a major population (approximately 95%) of mis-ligated histidine to the heme which acts as a kinetic trap in the folding process.	Histidine	170-179	cytochrome c, somatic	Homo sapiens	35-47
9693734-9	1998	These results are consistent with the three-dimensional cytochrome c oxidase structure which shows that the entry point to the D-pathway (but not to the K-pathway) is surrounded by a network of histidine residues within a negative electrostatic potential.	Histidine	194-203	cytochrome c, somatic	Homo sapiens	56-68
9520398-10	1998	Disruption of histone deacetylase activity either by TPX or by direct mutation of a histidine presumed to be in the active site abrogates HDAC1-mediated transcriptional repression of a targeted reporter gene in vivo.	Histidine	84-93	histone deacetylase 1	Homo sapiens	138-143
9582326-10	1998	In contrast, complex p38.p37.p36-his displayed no ATPase, suggesting that p40 is essential for ATPase activity.	Histidine	33-36	mitogen-activated protein kinase 14	Homo sapiens	21-24
9582326-11	1998	Although p38 was not required for ATPase activity, the activity of the p40-his.p38.p37.	Histidine	75-78	mitogen-activated protein kinase 14	Homo sapiens	9-12
9582326-11	1998	Although p38 was not required for ATPase activity, the activity of the p40-his.p38.p37.	Histidine	75-78	mitogen-activated protein kinase 14	Homo sapiens	79-82
9590360-0	1998	Rapid capillary zone electrophoresis in isoelectric histidine buffer: high resolution of the poly-T tract allelic variants in intron 8 of the CFTR gene.	Histidine	52-61	CF transmembrane conductance regulator	Homo sapiens	142-146
9602025-1	1998	Based on circular dichroism (CD), we have found an essential (i, i + 4) alpha-helix stabilizing array in the C-terminus region for the cholesteryl ester transfer protein (CETP) between histidine 466 and aspartic acid 470.	Histidine	185-194	cholesteryl ester transfer protein	Homo sapiens	135-169
9602025-1	1998	Based on circular dichroism (CD), we have found an essential (i, i + 4) alpha-helix stabilizing array in the C-terminus region for the cholesteryl ester transfer protein (CETP) between histidine 466 and aspartic acid 470.	Histidine	185-194	cholesteryl ester transfer protein	Homo sapiens	171-175
9581865-5	1998	Not only murine but also human mutant p53 proteins carrying the mutational hot spot amino acid exchanges 175Arg--&gt;His, 273Arg--&gt;Pro, or 273Arg--&gt;His bound to the Xbal-IgE-MAR-DNA fragment.	Histidine	117-120	tumor protein p53	Homo sapiens	38-41
9581865-5	1998	Not only murine but also human mutant p53 proteins carrying the mutational hot spot amino acid exchanges 175Arg--&gt;His, 273Arg--&gt;Pro, or 273Arg--&gt;His bound to the Xbal-IgE-MAR-DNA fragment.	Histidine	154-157	tumor protein p53	Homo sapiens	38-41
9585419-1	1998	The amyloid-beta peptide (Abeta) can mediate cell attachment by binding to beta1 integrins through an arg-his-asp sequence.	Histidine	106-109	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	75-80
9605749-3	1998	A carboxyl-terminal fragment containing the last 92 amino acids of p53 (GST-299-390) was sufficient for binding to topoisomerase I. Nanomolar concentrations of either GST-p53 or GST-299-390 enhanced the catalytic activity of purified human topoisomerase I. Purified wild-type human p53 and point mutants Ser-239, Ser-245, and His-273 were equivalent in their enhancement of human topoisomerase I activity.	Histidine	326-329	tumor protein p53	Homo sapiens	67-70
9605749-3	1998	A carboxyl-terminal fragment containing the last 92 amino acids of p53 (GST-299-390) was sufficient for binding to topoisomerase I. Nanomolar concentrations of either GST-p53 or GST-299-390 enhanced the catalytic activity of purified human topoisomerase I. Purified wild-type human p53 and point mutants Ser-239, Ser-245, and His-273 were equivalent in their enhancement of human topoisomerase I activity.	Histidine	326-329	tumor protein p53	Homo sapiens	171-174
9605749-3	1998	A carboxyl-terminal fragment containing the last 92 amino acids of p53 (GST-299-390) was sufficient for binding to topoisomerase I. Nanomolar concentrations of either GST-p53 or GST-299-390 enhanced the catalytic activity of purified human topoisomerase I. Purified wild-type human p53 and point mutants Ser-239, Ser-245, and His-273 were equivalent in their enhancement of human topoisomerase I activity.	Histidine	326-329	tumor protein p53	Homo sapiens	171-174
9584213-7	1998	Shifting the position of the histidine from the beta1 subunit to the aligned position in alpha1 with the two mutants alpha1S272Hbeta1H267S reduced the affinity (IC50 = 26 micro M) compared with wild-type.	Histidine	29-38	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	48-53
9528793-5	1998	The transactivation function of Ets-1 correlated with its ability to bind an N-terminal cysteine- and histidine-rich region spanning CBP residues 313 to 452.	Histidine	102-111	CREB binding protein	Homo sapiens	133-136
9528793-6	1998	Ets-1 also bound a second cysteine- and histidine-rich region of CBP, between residues 1449 and 1892.	Histidine	40-49	CREB binding protein	Homo sapiens	65-68
9514759-1	1998	The structural stability of recombinant human growth hormone (rhGH) has been studied by differential scanning calorimetry, circular dichroism and by following the tyrosine and histidine chemical shifts in the 1H NMR spectrum.	Histidine	176-185	growth hormone 1	Homo sapiens	46-60
9507013-3	1998	We have expressed rPLD1 as a histidine-tagged fusion protein in insect (Sf9) cells using the expression vector pBlueBacHis and purified the recombinant protein to homogeneity by Ni2+-agarose affinity chromatography.	Histidine	29-38	phospholipase D1	Rattus norvegicus	18-23
9516042-5	1998	We submit that histidine clusters, residing both in the Alzheimer"s beta-amyloid peptide and in most of the APP/APLP superfamily of proteins, constitute high-affinity binding sites for immobilized metal chelates.	Histidine	15-24	amyloid beta precursor protein	Homo sapiens	68-88
9472015-5	1998	We demonstrate that recombinant His-tagged HMG-1 enhances p53 DNA binding in vitro and also that HMG-1 and p53 can interact directly in vitro.	Histidine	32-35	high mobility group box 1 pseudogene 5	Homo sapiens	43-48
9472015-5	1998	We demonstrate that recombinant His-tagged HMG-1 enhances p53 DNA binding in vitro and also that HMG-1 and p53 can interact directly in vitro.	Histidine	32-35	tumor protein p53	Homo sapiens	58-61
9472015-5	1998	We demonstrate that recombinant His-tagged HMG-1 enhances p53 DNA binding in vitro and also that HMG-1 and p53 can interact directly in vitro.	Histidine	32-35	high mobility group box 1 pseudogene 5	Homo sapiens	97-102
9472015-5	1998	We demonstrate that recombinant His-tagged HMG-1 enhances p53 DNA binding in vitro and also that HMG-1 and p53 can interact directly in vitro.	Histidine	32-35	tumor protein p53	Homo sapiens	107-110
9754041-11	1998	While the number of positively charged amino acids like arginine and leucine was increased, histidine containing weakly ionized group and having a significant buffering capacity was reduced to a major extent, further suggesting that the acidic nature of calmodulin protein has been maintained during evolution.	Histidine	92-101	calmodulin 1	Homo sapiens	254-264
9512514-4	1998	Here, we describe four Rpd3 derivatives with mutations in evolutionarily invariant histidine residues in a putative deacetylation motif.	Histidine	83-92	histone deacetylase RPD3	Saccharomyces cerevisiae S288C	23-27
9575335-4	1998	Some of them use a catalytic Cys/His/Glu triad similar to serine protease, whereas the aminoterminal cysteine of the others is believed to play the same function.	Histidine	33-36	coagulation factor II, thrombin	Homo sapiens	58-73
9501916-3	1998	In this new model, unfolded cytochrome c is converted to its native structure through an obligatory folding intermediate, the histidine-water coordination state, whereas the five-coordinate state and a bis-histidine state are off-pathway intermediates.	Histidine	126-135	cytochrome c, somatic	Homo sapiens	28-40
9488635-0	1998	Haemoglobin J-Biskra: a new mildly unstable alpha1 gene variant with a deletion of eight residues (alpha50-57, alpha51-58 or alpha52-59) including the distal histidine.	Histidine	158-167	BCL2 related protein A1	Homo sapiens	44-50
9454573-1	1998	Single tryptophan mutants of a histidine-tagged G(o)alpha (W132F and W212F) were prepared to examine the functional and spectroscopic role of tryptophan in G(o)alpha.	Histidine	31-40	tripartite motif containing 47	Homo sapiens	48-57
9510129-1	1998	The distal and proximal histidines in thyroid peroxidase (TPO), located by amino acid sequence alignment with their known counterparts in myeloperoxidase, are His 239 and His 494, respectively.	Histidine	24-34	myeloperoxidase	Homo sapiens	138-153
9510129-1	1998	The distal and proximal histidines in thyroid peroxidase (TPO), located by amino acid sequence alignment with their known counterparts in myeloperoxidase, are His 239 and His 494, respectively.	Histidine	159-162	myeloperoxidase	Homo sapiens	138-153
9510129-1	1998	The distal and proximal histidines in thyroid peroxidase (TPO), located by amino acid sequence alignment with their known counterparts in myeloperoxidase, are His 239 and His 494, respectively.	Histidine	171-174	myeloperoxidase	Homo sapiens	138-153
9493268-11	1998	The pH dependence of IgG binding to FcRn can therefore primarily be attributed to titration of histidine residues on Fc that interact with anionic pockets on the receptor.	Histidine	95-104	Fc gamma receptor and transporter	Homo sapiens	36-40
9493268-12	1998	The FcRn dimer, which is required for high affinity binding of IgG, is itself stabilized at acidic pH by histidine-mediated salt bridges and a sidechain rearrangement that creates a more favorable interaction with an anionic pocket at pH 6.5 relative to pH 8.	Histidine	105-114	Fc gamma receptor and transporter	Homo sapiens	4-8
9354703-0	1997	Functional expression and purification of histidine-tagged rat renal Na/Phosphate (NaPi-2) and Na/Sulfate (NaSi-1) cotransporters.	Histidine	42-51	solute carrier family 34 member 1	Rattus norvegicus	83-89
10026993-15	1998	Polymorphic variants of mEH were associated with hepatocellular cancer (His-113 allele), ovarian cancer (Tyr-113 allele) and chronic obstructive pulmonary disease (His-113 allele).	Histidine	72-75	epoxide hydrolase 1, microsomal	Mus musculus	24-27
10026993-15	1998	Polymorphic variants of mEH were associated with hepatocellular cancer (His-113 allele), ovarian cancer (Tyr-113 allele) and chronic obstructive pulmonary disease (His-113 allele).	Histidine	164-167	epoxide hydrolase 1, microsomal	Mus musculus	24-27
9395474-4	1997	Mutation of the histidine (H43Q) or aspartic acid (D45A) residues of this motif reduced the ability of Csp to stimulate the ATPase activity of mammalian Hsc70.	Histidine	16-25	DnaJ heat shock protein family (Hsp40) member C5	Homo sapiens	103-106
9388263-1	1997	It has been shown that the relative reaction preference of the C4 thiol ester toward oxygen and nitrogen nucleophiles upon activation by proteinase depends on whether residue 1106 is aspartate or histidine (Dodds, A. W., Ren, X.-D., Willis, A. C., and Law, S. K. A.	Histidine	196-205	renin	Homo sapiens	221-224
9398185-1	1997	Triosephosphate isomerase (TIM) catalyzes the reversible interconversion of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GAP), with Glu-165 removing the pro-R proton from C1 of DHAP and neutral His-95 polarizing the carbonyl group of the substrate.	Histidine	215-218	triosephosphate isomerase 1	Homo sapiens	0-25
9398185-1	1997	Triosephosphate isomerase (TIM) catalyzes the reversible interconversion of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GAP), with Glu-165 removing the pro-R proton from C1 of DHAP and neutral His-95 polarizing the carbonyl group of the substrate.	Histidine	215-218	triosephosphate isomerase 1	Homo sapiens	27-30
9398185-4	1997	In the TIM-PGH complex, His-95 N epsilon H shows a slow, pH-independent exchange rate with water (kex = 80 s-1 at 30 degrees C, Eact = 19 kcal/mol), which is 44-fold slower than that of an exposed histidine suggesting partial shielding from bulk solvent, and a fractionation factor phi = 0.71 +/- 0.02 consistent with its donation of a normal hydrogen bond.	Histidine	24-27	triosephosphate isomerase 1	Homo sapiens	7-10
9398185-4	1997	In the TIM-PGH complex, His-95 N epsilon H shows a slow, pH-independent exchange rate with water (kex = 80 s-1 at 30 degrees C, Eact = 19 kcal/mol), which is 44-fold slower than that of an exposed histidine suggesting partial shielding from bulk solvent, and a fractionation factor phi = 0.71 +/- 0.02 consistent with its donation of a normal hydrogen bond.	Histidine	197-206	triosephosphate isomerase 1	Homo sapiens	7-10
9398207-1	1997	Human serum transferrin N-lobe (hTF/2N) has four iron-binding ligands, including one histidine, one aspartate, and two tyrosines.	Histidine	85-94	transferrin	Homo sapiens	12-23
9434897-3	1997	The recent structure determinations of several proteins from the PTS-mediated pathway, the phosphotransfer domain from the kinase CheA of the MCP-mediated chemotaxis pathway, and a homologous kinase, ArcB, enable the comparison of the histidine active sites of these systems.	Histidine	235-244	CD46 molecule	Homo sapiens	142-145
9409355-3	1997	We detected a point mutation at codon 48 of the Cu/Zn superoxide dismutase gene (SOD1) leading to a substitution of histidine by glutamine in the copper-binding domain.	Histidine	116-125	superoxide dismutase 1	Homo sapiens	48-74
9409355-3	1997	We detected a point mutation at codon 48 of the Cu/Zn superoxide dismutase gene (SOD1) leading to a substitution of histidine by glutamine in the copper-binding domain.	Histidine	116-125	superoxide dismutase 1	Homo sapiens	81-85
9414554-0	1997	Identification of active-site histidine residues of a self-incompatibility ribonuclease from a wild tomato.	Histidine	30-39	intracellular ribonuclease LX	Solanum lycopersicum	75-87
9409331-0	1997	Copper ions promote peroxidation of low density lipoprotein lipid by binding to histidine residues of apolipoprotein B100, but they are reduced at other sites on LDL.	Histidine	80-89	apolipoprotein B	Homo sapiens	102-121
9374873-9	1997	The results, coupled with a molecular modeling study, suggest that Arg-717 of neprilysin corresponds to Arg-203 of thermolysin and that in both enzymes a hydrogen bond network exists, involving His-142, Asp-170, and Arg-203 in thermolysin and His-583, Asp-650, and Arg-717 in neprilysin, which is crucial for hydrolytic activity.	Histidine	194-197	membrane metalloendopeptidase	Homo sapiens	78-88
9374873-9	1997	The results, coupled with a molecular modeling study, suggest that Arg-717 of neprilysin corresponds to Arg-203 of thermolysin and that in both enzymes a hydrogen bond network exists, involving His-142, Asp-170, and Arg-203 in thermolysin and His-583, Asp-650, and Arg-717 in neprilysin, which is crucial for hydrolytic activity.	Histidine	243-246	membrane metalloendopeptidase	Homo sapiens	78-88
9408996-11	1997	Chromatography of human interleukin-1 beta (hIL-1 beta) and several other proteins containing a single surface-exposed histidine surrounded by several hydrophobic residues confirmed that such a sequence could also serve as a very effective metal binding domain for protein purification using immobilized copper(II) columns.	Histidine	119-128	interleukin 1 beta	Homo sapiens	24-42
9408996-11	1997	Chromatography of human interleukin-1 beta (hIL-1 beta) and several other proteins containing a single surface-exposed histidine surrounded by several hydrophobic residues confirmed that such a sequence could also serve as a very effective metal binding domain for protein purification using immobilized copper(II) columns.	Histidine	119-128	interleukin 1 beta	Homo sapiens	44-54
9432011-1	1997	Histidase (histidine ammonia-lyase) is a cytosolic enzyme responsible for catalyzing the non-oxidative deamination of histidine to urocanic acid.	Histidine	11-20	histidine ammonia lyase	Rattus norvegicus	0-9
9409331-5	1997	In the current studies, we used diethylpyrocarbonate (DEPC) to modify the histidine residues of apolipoprotein B100, the major protein in LDL.	Histidine	74-83	apolipoprotein B	Homo sapiens	96-115
9409331-12	1997	These observations suggest that peroxidation of the lipids in LDL can proceed with normal kinetics only when Cu2+ binds preferentially to sites on apolipoprotein B100 that contain histidine residues.	Histidine	180-189	apolipoprotein B	Homo sapiens	147-166
9352462-2	1997	In vitro, peptide Piv-His-Pro-Phe-His-Leu-psi[CH(OH)CH2]Leu-Tyr-Tyr-Ser-NH2(XXI) is the most potent inhibitor of rat plasma renin reported having an IC50 of 0.21 nM; it is a much weaker inhibitor of human renin (IC50 45 nM).	Histidine	22-25	renin	Homo sapiens	205-210
9351810-8	1997	In E. coli PNP, the purine- and ribose-binding sites are generally hydrophobic, although a histidine residue from an adjacent subunit probably forms a hydrogen bond with a hydroxyl group of the sugar.	Histidine	91-100	purine nucleoside phosphorylase	Homo sapiens	11-14
9352462-2	1997	In vitro, peptide Piv-His-Pro-Phe-His-Leu-psi[CH(OH)CH2]Leu-Tyr-Tyr-Ser-NH2(XXI) is the most potent inhibitor of rat plasma renin reported having an IC50 of 0.21 nM; it is a much weaker inhibitor of human renin (IC50 45 nM).	Histidine	34-37	renin	Homo sapiens	205-210
9261348-4	1997	Sequence analysis of the U5 and PBS regions of integrated provirus from a cell culture infected with virus derived from pHXB2(His-AC-TGT) revealed a G-to-A change in CCTGT at nucleotide 181 after limited in vitro culture, suggesting that this nucleotide change represented an adaptation by the virus to efficiently utilize tRNA(His) to initiate reverse transcription.	Histidine	126-129	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	133-136
9311786-5	1997	Concomitantly, a refolding of the cytochrome c domain takes place, resulting in an unexpected change of the c haem iron coordination from His 17/His 69 to Met106/His69.	Histidine	138-141	cytochrome c, somatic	Homo sapiens	34-46
9261348-9	1997	The initiation of reverse transcription was delayed in viruses derived from pHXB2(His-AC-TGT) with wild-type RT and M184V RT compared to viruses derived from pHXB2(His-AC-GAC).	Histidine	82-85	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	89-92
9256252-3	1997	Based on biochemical and spectroscopic data, His-PrP displays characteristics expected for the PrP(C) isoform.	Histidine	45-48	prion protein	Homo sapiens	95-101
9310371-6	1997	Among the mutant proteins, [H57-H62, G63-G65]ET(B)R, carrying six His residues in the N-terminal tail, was studied extensively because it was purified most effectively.	Histidine	66-69	endothelin receptor type B	Homo sapiens	45-51
9273895-4	1997	Peptide Boc-His-Pro-Phe-His-Sta-Val-Ile-His-NH2 (VI) is the best inhibitor of human renin containing Sta at position 10.	Histidine	12-15	renin	Homo sapiens	84-89
9273895-4	1997	Peptide Boc-His-Pro-Phe-His-Sta-Val-Ile-His-NH2 (VI) is the best inhibitor of human renin containing Sta at position 10.	Histidine	24-27	renin	Homo sapiens	84-89
9273895-4	1997	Peptide Boc-His-Pro-Phe-His-Sta-Val-Ile-His-NH2 (VI) is the best inhibitor of human renin containing Sta at position 10.	Histidine	24-27	renin	Homo sapiens	84-89
9272683-4	1997	Since apoA-IV has a common DNA based protein polymorphism with a different function we determined apoA-IV (360:Gln:His) DNA polymorphism in 63 late-onset sporadic Alzheimer"s patients.	Histidine	115-118	apolipoprotein A4	Homo sapiens	6-13
9288904-3	1997	The protein has high similarity to other peroxidases and contains two peroxidase motifs that carry two highly conserved histidines in the active center.	Histidine	120-130	peroxidase 1	Zea mays	41-51
9154814-6	1997	We have directly tested for cooperativity between neu and mutant p53 in mammary tumorigenesis by creating bitransgenic mice carrying MMTV-neu and 172Arg-to-His p53 mutant (p53-172H).	Histidine	156-159	tumor protein p53	Homo sapiens	160-163
9189046-3	1997	A point mutation was identified in all of them at position 101 of the gene for alpha-TTP, where histidine (CAT) was replaced with glutamine (CAG).	Histidine	96-105	catalase	Homo sapiens	107-110
9192170-7	1997	RESULTS: Histidine immunoreactivity was identified in the ganglion cell layer (GCL), inner nuclear layer (INL), inner plexiform layer (IPL), and Muller cells of rat retina.	Histidine	9-18	germ cell-less 1, spermatogenesis associated	Rattus norvegicus	79-82
9266488-1	1997	A 32 amino acid peptide called histatin-3 (H3; 22% His) and its N-terminal 24 amino acid fragment histatin-5 (H5, 33% His), are found in human saliva and possess powerful antimicrobial properties.	Histidine	51-54	histatin 3	Homo sapiens	31-41
9266488-1	1997	A 32 amino acid peptide called histatin-3 (H3; 22% His) and its N-terminal 24 amino acid fragment histatin-5 (H5, 33% His), are found in human saliva and possess powerful antimicrobial properties.	Histidine	51-54	histatin 3	Homo sapiens	43-45
9266488-1	1997	A 32 amino acid peptide called histatin-3 (H3; 22% His) and its N-terminal 24 amino acid fragment histatin-5 (H5, 33% His), are found in human saliva and possess powerful antimicrobial properties.	Histidine	118-121	histatin 3	Homo sapiens	31-41
9266488-1	1997	A 32 amino acid peptide called histatin-3 (H3; 22% His) and its N-terminal 24 amino acid fragment histatin-5 (H5, 33% His), are found in human saliva and possess powerful antimicrobial properties.	Histidine	118-121	histatin 3	Homo sapiens	98-108
9266488-1	1997	A 32 amino acid peptide called histatin-3 (H3; 22% His) and its N-terminal 24 amino acid fragment histatin-5 (H5, 33% His), are found in human saliva and possess powerful antimicrobial properties.	Histidine	118-121	histatin 3	Homo sapiens	110-112
9266488-6	1997	The 9-24 segment of H3 with all the His at positions 15,18,19,21 replaced by Tyr was also prepared (delta 1-8 H3Y).	Histidine	36-39	histatin 3	Homo sapiens	20-22
9220002-19	1997	The finBcs103 mutation is a His-87--&gt;Tyr change in Nu1.	Histidine	28-31	DNA-packaging protein	Escherichia virus Lambda	54-57
9266711-2	1997	Several conserved histidine residues in hydrophobic regions of CP47 have been shown to be important for photosystem II structure, function, and energy transfer.	Histidine	18-27	beaded filament structural protein 2	Homo sapiens	63-67
9266711-7	1997	The observation that mutation of histidine residues to tyrosine has more drastic effects than mutation of these residues to glutamine is in agreement with results obtained for CP47 and suggests the involvement of these residues in chlorophyll binding.	Histidine	33-42	beaded filament structural protein 2	Homo sapiens	176-180
9266711-8	1997	The drastic functional changes observed upon mutating His40 and His105 of CP43 are similar to those observed when mutating the corresponding histidine residues in CP47, thus suggesting that the similarity between CP43 and CP47 extends to the relative importance of functionally relevant residues.	Histidine	141-150	beaded filament structural protein 2	Homo sapiens	163-167
9266711-8	1997	The drastic functional changes observed upon mutating His40 and His105 of CP43 are similar to those observed when mutating the corresponding histidine residues in CP47, thus suggesting that the similarity between CP43 and CP47 extends to the relative importance of functionally relevant residues.	Histidine	141-150	beaded filament structural protein 2	Homo sapiens	222-226
9211922-5	1997	This mutant is functionally similar to the MAC1(up1) allele in which His-279 in the same domain has been replaced by Gln.	Histidine	69-72	Mac1p	Saccharomyces cerevisiae S288C	43-47
9247172-6	1997	The expressed Pgp can be solubilized from the yeast membranes with lysophosphatidylcholine, and when tagged with ten histidines at its C-terminus, can be readily purified to about 90% homogeneity by Ni2+ affinity chromatography.	Histidine	117-127	ATP binding cassette subfamily B member 1	Homo sapiens	14-17
9201935-3	1997	When migrated across a wide pH range in the presence of varying amounts of urea to display its titration curve, apoA-I is resolved into two pairs of bands, running parallel in the neutral to basic pH region while merging at acidic pH; such a finding does not correlate with a differential exposure of His residues, as shown by diethyl pyrocarbonate titration.	Histidine	301-304	apolipoprotein A1	Homo sapiens	112-118
9186309-3	1997	His-DTrp-Ala-Trp-DPhe-Lys-NH2 [GH-releasing peptide-6 [GHRP-6]] is a synthetic hexapeptide that stimulates GH release in vitro and in vivo.	Histidine	0-3	growth hormone 1	Homo sapiens	31-33
9154814-6	1997	We have directly tested for cooperativity between neu and mutant p53 in mammary tumorigenesis by creating bitransgenic mice carrying MMTV-neu and 172Arg-to-His p53 mutant (p53-172H).	Histidine	156-159	tumor protein p53	Homo sapiens	160-163
9139709-2	1997	In the primary sequence of the constitutive form, HO-2, there are three potential heme binding sites: two heme regulatory motifs (HRMs) with the absolutely conserved Cys-Pro pair, and a conserved 24-residue heme catalytic pocket with a histidine residue, His151 in rat HO-2.	Histidine	236-245	heme oxygenase 2	Rattus norvegicus	50-54
9187266-0	1997	Role of conserved histidines in catalytic activity and inhibitor binding of human recombinant phosphodiesterase 4A.	Histidine	18-28	phosphodiesterase 4A	Homo sapiens	94-114
27406964-2	1997	Cu(2+) may play an important role in LDL oxidation by binding to histidine residues of apolipoprotein B-100 (apo B) and initiating and propagating lipid peroxidation.	Histidine	65-74	apolipoprotein B	Homo sapiens	87-107
9159110-9	1997	Additional MAC1(up) alleles exist within the first of two cysteine-rich sequence motifs adjacent to the His --&gt; Gln MAC1(up1) encoded substitution.	Histidine	104-107	Mac1p	Saccharomyces cerevisiae S288C	11-15
9159110-9	1997	Additional MAC1(up) alleles exist within the first of two cysteine-rich sequence motifs adjacent to the His --&gt; Gln MAC1(up1) encoded substitution.	Histidine	104-107	Mac1p	Saccharomyces cerevisiae S288C	119-123
9166791-0	1997	Roles of histidine 31 and tryptophan 34 in the structure, self-association, and folding of murine interleukin-6.	Histidine	9-18	interleukin 6	Mus musculus	98-111
15299933-5	1997	The new structure provides support for the conclusion that the unique properties of leghemoglobin arise principally from a heme pocket considerably larger and more flexible than that of myoglobin, a strongly ruffled heme group, and a proximal histidine orientation more favourable to ligand binding.	Histidine	243-252	leghemoglobin A	Glycine max	84-97
9177475-2	1997	Oxytocinase is a type II integral membrane protein of 1025 amino acid residues, consisting of an acidic intracellular region of 110 amino acids followed by a hydrophobic transmembrane segment of 22 residues and 893 extracellular residues containing the characteristic Zn2+ coordination sequence element His-Glu-Xaa-Xaa-His-(18 residues)-Glu found in gluzincins.	Histidine	303-306	leucyl and cystinyl aminopeptidase	Homo sapiens	0-11
9177475-2	1997	Oxytocinase is a type II integral membrane protein of 1025 amino acid residues, consisting of an acidic intracellular region of 110 amino acids followed by a hydrophobic transmembrane segment of 22 residues and 893 extracellular residues containing the characteristic Zn2+ coordination sequence element His-Glu-Xaa-Xaa-His-(18 residues)-Glu found in gluzincins.	Histidine	319-322	leucyl and cystinyl aminopeptidase	Homo sapiens	0-11
9283639-5	1997	Right and left ventricular (RV, LV) muscle and scar tissue homogenates were prepared to determine ACE activity in vitro by measuring the velocity of His-Leu release from the synthetic substrate Hyp-His-Leu.	Histidine	198-201	angiotensin I converting enzyme	Rattus norvegicus	98-101
9283639-6	1997	ACE activity was corrected to the tissue wet weight and is reported as nmol His-Leu g-1 min-1.	Histidine	76-79	angiotensin I converting enzyme	Rattus norvegicus	0-3
9283639-11	1997	In rats studied two weeks after surgery, ACE activity in the LV muscle increased from 105 +/- 7 nmol His-Leu g-1 min-1 in control hearts to 153 +/- 11 nmol His-Leu g-1 min-1 (P &lt; 0.05) in the remaining LV muscle of MI rats and to 1051 +/- 208 nmol His-Leu g-1 min-1 (P &lt; 0.001) in the fibrous scar.	Histidine	101-104	angiotensin I converting enzyme	Rattus norvegicus	41-44
9283639-11	1997	In rats studied two weeks after surgery, ACE activity in the LV muscle increased from 105 +/- 7 nmol His-Leu g-1 min-1 in control hearts to 153 +/- 11 nmol His-Leu g-1 min-1 (P &lt; 0.05) in the remaining LV muscle of MI rats and to 1051 +/- 208 nmol His-Leu g-1 min-1 (P &lt; 0.001) in the fibrous scar.	Histidine	156-159	angiotensin I converting enzyme	Rattus norvegicus	41-44
9283639-11	1997	In rats studied two weeks after surgery, ACE activity in the LV muscle increased from 105 +/- 7 nmol His-Leu g-1 min-1 in control hearts to 153 +/- 11 nmol His-Leu g-1 min-1 (P &lt; 0.05) in the remaining LV muscle of MI rats and to 1051 +/- 208 nmol His-Leu g-1 min-1 (P &lt; 0.001) in the fibrous scar.	Histidine	156-159	angiotensin I converting enzyme	Rattus norvegicus	41-44
9183014-3	1997	When the single conservative amino acid difference between the two sequences (Tyr--&gt;His) was introduced into the mouse laminin binding module gamma1 III4 it failed to cause any change of binding.	Histidine	87-90	Laminin A	Drosophila melanogaster	122-129
9092499-6	1997	The fusion protein was affinity-purified and digested with thrombin to remove the histidine tag.	Histidine	82-91	coagulation factor II	Rattus norvegicus	59-67
9099683-10	1997	This particular sequence homology extends C-terminally beyond the typical cysteine/histidine core structure and is DGK-specific.	Histidine	83-92	diacylglycerol kinase beta	Homo sapiens	115-118
9186907-0	1997	Human lysosomal acid lipase/cholesteryl ester hydrolase and human gastric lipase: identification of the catalytically active serine, aspartic acid, and histidine residues.	Histidine	152-161	lipase F, gastric type	Homo sapiens	66-80
9186907-7	1997	Structural integrity of the conserved His-Gly dipeptide of lipases also appears to be important for neutral lipid hydrolysis, as replacement of His65 by glutamine abolished HLAL and HGL enzymic activity.	Histidine	38-41	lipase F, gastric type	Homo sapiens	182-185
9601847-3	1997	The sequential analysis of the beta-globin gene provided evidence that the cause is mutation CAT-AAT in codon 63 which leads to the exchange of distal histidine /E7/ for asparagine.	Histidine	151-160	serpin family A member 1	Homo sapiens	97-100
9108303-4	1997	The pH dependence of both thermal stability and zinc binding surrounding the pKa of histidine suggests that these residues plays a key role in the structural integrity of bovine prolactin.	Histidine	84-93	prolactin	Bos taurus	178-187
9083026-0	1997	Metal-catalyzed oxidation of histidine in human growth hormone.	Histidine	29-38	growth hormone 1	Homo sapiens	48-62
9092797-1	1997	An androgen receptor (AR) gene mutation identified in the androgen-dependent human prostate cancer xenograft, CWR22, changed codon 874 in the ligand-binding domain (exon H) from CAT for histidine to TAT for tyrosine and abolished a restriction site for the endonuclease SfaNI.	Histidine	186-195	androgen receptor	Homo sapiens	3-20
9092797-1	1997	An androgen receptor (AR) gene mutation identified in the androgen-dependent human prostate cancer xenograft, CWR22, changed codon 874 in the ligand-binding domain (exon H) from CAT for histidine to TAT for tyrosine and abolished a restriction site for the endonuclease SfaNI.	Histidine	186-195	androgen receptor	Homo sapiens	22-24
9042858-6	1997	Deletion mutagenesis of the MyoD protein demonstrated that the ability to activate endogenous genes depended on two regions: a region rich in cysteine and histidine residues between the acidic activation domain and the bHLH domain, and a second region in the carboxyl terminus of the protein.	Histidine	155-164	myogenic differentiation 1	Homo sapiens	28-32
9132061-13	1997	However, they do show two differences of importance to peroxidase catalysis: (1) the asparagine residue linked with the active site distal histidine via hydrogen bonding is absent; (2) an N-glycosylation site is located right at the entrance to the heme channel.	Histidine	139-148	peroxidase	Arabidopsis thaliana	55-65
9048595-2	1997	Somatostatin inhibited basal and gastrin-stimulated histamine synthesis through a dual mechanism involving a decrease in the affinity of histidine decarboxylase (HDC) for its substrate (L-histidine) and a reduction in the number of functional HDC molecules.	Histidine	186-197	somatostatin	Oryctolagus cuniculus	0-12
9048595-4	1997	Furthermore, forskolin was shown to reverse the inhibitory effect of H-89 and to prevent the somatostatin-induced reduction in HDC affinity for L-histidine.	Histidine	144-155	somatostatin	Oryctolagus cuniculus	93-105
9070444-5	1997	These results with iso-2 cytochrome c strongly support the hypothesis that non-native His-heme ligation results in a kinetic barrier to fast folding of cytochrome c.	Histidine	86-89	cytochrome c, somatic	Homo sapiens	25-37
9070444-5	1997	These results with iso-2 cytochrome c strongly support the hypothesis that non-native His-heme ligation results in a kinetic barrier to fast folding of cytochrome c.	Histidine	86-89	cytochrome c, somatic	Homo sapiens	152-164
9041634-3	1997	The chicken sarcomeric muscle mitochondrial isoenzyme Mib-CK contains several histidine residues that are conserved throughout the family of creatine kinases.	Histidine	78-87	creatine kinase, mitochondrial 2	Gallus gallus	54-60
9017214-6	1997	This pumping behavior is similar to that seen in a related bacterial rhodopsin, archaerhodopsin-1, which has a histidine in the position analogous to K129.	Histidine	111-120	rhodopsin	Homo sapiens	69-78
8999905-3	1997	In order to obtain a more detailed characterization of these subdomains, we examined the binding of an insulin superanalog, des-(B25-30)-[His-A8, Asp-B10, Tyr-B25 alpha-carboxamide]insulin, to alanine mutants of the ligand binding determinants of these subdomains.	Histidine	138-141	insulin	Homo sapiens	103-110
8999905-5	1997	In general des-(B25-30)-[His-A8, Asp-B10, Tyr-B25 alpha-carboxamide]insulin binding correlated with insulin binding, suggesting that both peptides bound to the receptor in a similar manner.	Histidine	25-28	insulin	Homo sapiens	68-75
8999905-7	1997	Mutation of Arg14 and His710 to Ala produced receptors with undetectable insulin binding but an affinity for des-(B25-30)-[His-A8, Asp-B10, Tyr-B25 alpha-carboxamide]insulin only 8-23-fold less than for native receptor.	Histidine	22-25	insulin	Homo sapiens	73-80
8999905-7	1997	Mutation of Arg14 and His710 to Ala produced receptors with undetectable insulin binding but an affinity for des-(B25-30)-[His-A8, Asp-B10, Tyr-B25 alpha-carboxamide]insulin only 8-23-fold less than for native receptor.	Histidine	22-25	insulin	Homo sapiens	166-173
9025937-0	1997	Metal-catalyzed photooxidation of histidine in human growth hormone.	Histidine	34-43	growth hormone 1	Homo sapiens	53-67
9030191-1	1997	Human apolipoprotein A-I (apoA-I), with an additional N-terminal extension (Met-Arg-Gly-Ser-(His)6-Met) (His-apoA-I), has been produced in Escherichia coli with a final yield after purification of 10 mg protein/1 of culture medium.	Histidine	93-96	apolipoprotein A1	Homo sapiens	6-24
8995407-0	1997	Ligand perturbation effects on a pseudotetrahedral Co(II)(His)3-ligand site.	Histidine	58-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-57
9003198-3	1997	In hPEPT1, these residues are His-57, His-121, and His-260.	Histidine	30-33	solute carrier family 15 member 1	Homo sapiens	3-9
9003198-3	1997	In hPEPT1, these residues are His-57, His-121, and His-260.	Histidine	38-41	solute carrier family 15 member 1	Homo sapiens	3-9
9003198-3	1997	In hPEPT1, these residues are His-57, His-121, and His-260.	Histidine	38-41	solute carrier family 15 member 1	Homo sapiens	3-9
9003198-4	1997	The corresponding residues in hPEPT2 are His-87, His-142, and His-278.	Histidine	41-44	solute carrier family 15 member 2	Homo sapiens	30-36
9003198-4	1997	The corresponding residues in hPEPT2 are His-87, His-142, and His-278.	Histidine	49-52	solute carrier family 15 member 2	Homo sapiens	30-36
9003198-4	1997	The corresponding residues in hPEPT2 are His-87, His-142, and His-278.	Histidine	49-52	solute carrier family 15 member 2	Homo sapiens	30-36
9003198-6	1997	His-57 in hPEPT1 and His-87 in hPEPT2 were found to be absolutely essential for catalytic activity because the corresponding mutants had no detectable peptide transport activity.	Histidine	0-3	solute carrier family 15 member 1	Homo sapiens	10-16
9003198-6	1997	His-57 in hPEPT1 and His-87 in hPEPT2 were found to be absolutely essential for catalytic activity because the corresponding mutants had no detectable peptide transport activity.	Histidine	21-24	solute carrier family 15 member 2	Homo sapiens	31-37
9003198-7	1997	His-121 in hPEPT1 is not essential since mutation of this residue did not impair transport function.	Histidine	0-3	solute carrier family 15 member 1	Homo sapiens	11-17
9003198-8	1997	His-142 in hPEPT2 was found to play a significant role in the maintenance of transport function but was not found to be obligatory because the mutant had appreciable transport activity.	Histidine	0-3	solute carrier family 15 member 2	Homo sapiens	11-17
9003198-9	1997	The obligatory histidyl residue (His-57 in hPEPT1 and His-87 in hPEPT2) is located in an almost identical topological position in both transporters, near the extracellular surface of the second putative transmembrane domain.	Histidine	33-36	solute carrier family 15 member 1	Homo sapiens	43-49
9003198-9	1997	The obligatory histidyl residue (His-57 in hPEPT1 and His-87 in hPEPT2) is located in an almost identical topological position in both transporters, near the extracellular surface of the second putative transmembrane domain.	Histidine	33-36	solute carrier family 15 member 2	Homo sapiens	64-70
9003198-9	1997	The obligatory histidyl residue (His-57 in hPEPT1 and His-87 in hPEPT2) is located in an almost identical topological position in both transporters, near the extracellular surface of the second putative transmembrane domain.	Histidine	54-57	solute carrier family 15 member 2	Homo sapiens	64-70
9003198-12	1997	The loss of transport function of hPEPT1 and hPEPT2, when His-57 in hPEPT1 and His-87 in hPEPT2 were mutated, was not due to alterations in protein expression because the expression levels of these mutants were similar to those of the respective wild type transporters in HeLa cells as assessed by immunoblot analysis.	Histidine	58-61	solute carrier family 15 member 1	Homo sapiens	34-40
9003198-12	1997	The loss of transport function of hPEPT1 and hPEPT2, when His-57 in hPEPT1 and His-87 in hPEPT2 were mutated, was not due to alterations in protein expression because the expression levels of these mutants were similar to those of the respective wild type transporters in HeLa cells as assessed by immunoblot analysis.	Histidine	58-61	solute carrier family 15 member 2	Homo sapiens	45-51
9003198-12	1997	The loss of transport function of hPEPT1 and hPEPT2, when His-57 in hPEPT1 and His-87 in hPEPT2 were mutated, was not due to alterations in protein expression because the expression levels of these mutants were similar to those of the respective wild type transporters in HeLa cells as assessed by immunoblot analysis.	Histidine	58-61	solute carrier family 15 member 1	Homo sapiens	68-74
9003198-12	1997	The loss of transport function of hPEPT1 and hPEPT2, when His-57 in hPEPT1 and His-87 in hPEPT2 were mutated, was not due to alterations in protein expression because the expression levels of these mutants were similar to those of the respective wild type transporters in HeLa cells as assessed by immunoblot analysis.	Histidine	79-82	solute carrier family 15 member 1	Homo sapiens	34-40
9003198-12	1997	The loss of transport function of hPEPT1 and hPEPT2, when His-57 in hPEPT1 and His-87 in hPEPT2 were mutated, was not due to alterations in protein expression because the expression levels of these mutants were similar to those of the respective wild type transporters in HeLa cells as assessed by immunoblot analysis.	Histidine	79-82	solute carrier family 15 member 2	Homo sapiens	45-51
9003198-13	1997	Confocal analysis of immunofluorescence in X. laevis oocytes expressing the wild type and the three histidine mutants of hPEPT1 showed that the transporter protein is expressed exclusively in the plasma membrane and that the level of expression is comparable among the wild type and the three mutants.	Histidine	100-109	solute carrier family 15 member 1	Homo sapiens	121-127
9003198-14	1997	These site-directed mutagenesis studies clearly show that His-57 in hPEPT1 and His-87 in hPEPT2 are the most critical histidyl residues necessary for the catalytic function of these transporters.	Histidine	58-61	solute carrier family 15 member 1	Homo sapiens	68-74
9003198-14	1997	These site-directed mutagenesis studies clearly show that His-57 in hPEPT1 and His-87 in hPEPT2 are the most critical histidyl residues necessary for the catalytic function of these transporters.	Histidine	58-61	solute carrier family 15 member 2	Homo sapiens	89-95
9003198-14	1997	These site-directed mutagenesis studies clearly show that His-57 in hPEPT1 and His-87 in hPEPT2 are the most critical histidyl residues necessary for the catalytic function of these transporters.	Histidine	79-82	solute carrier family 15 member 2	Homo sapiens	89-95
8985102-3	1997	The mutant p53 gene (mp53: codon273Arg-His) was introduced into normal human fibroblasts (OUMS-24 line) and a G418-resistant clone, OUMS-24/P6 line, was obtained.	Histidine	39-42	tumor protein p53	Homo sapiens	11-14
8995407-3	1997	The His-B10 residues in this hexamer form tris imidazole chelates in which pseudotetrahedral Co(II) centers are completed by an exogenous fourth ligand.	Histidine	4-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-99
9016654-3	1996	TIF1 beta, TIF1 alpha, PML and efp belong to a characteristic subgroup of RING finger proteins that contain one or two other Cys/His-rich clusters (B boxes) and a putative coiled-coil in addition to the classical C3HC4 RING finger motif (RBCC configuration).	Histidine	129-132	tripartite motif containing 28	Homo sapiens	0-9
9000591-2	1997	One glioblastoma with hemizygous deletion of CDKN2A showed a missense mutation in exon 2 (codon 83) that would result in the substitution of tyrosine for histidine in the protein.	Histidine	154-163	cyclin dependent kinase inhibitor 2A	Homo sapiens	45-51
9027564-7	1997	Although the amino acid sequence of the GLUT4 COOH-terminal region is highly conserved among the species so far reported, one amino acid (Asp) of the region was replaced by His in bovine GLUT4.	Histidine	173-176	solute carrier family 2 member 4	Bos taurus	187-192
9437709-5	1997	Python neurokinin A (His-Lys-Thr-Asp-Ser-Phe-Val-Gly- Leu-Met.NH2) is identical to human/chicken/alligator neurokinin A.	Histidine	21-24	tachykinin precursor 1	Homo sapiens	7-19
8969219-7	1996	Energy minimization of a hypothetical enzyme complex modified by glutathione at Cys-298 revealed that the glycyl carboxylate of glutathione may participate in a charged interaction with His-110 in a manner strikingly similar to that involving the carboxylate group of the potent aldose reductase inhibitor Zopolrestat.	Histidine	186-189	aldo-keto reductase family 1 member B	Homo sapiens	279-295
9043672-3	1997	Experiments using NF-kappa B-beads showed that histidine-pyridine-histidine compounds and their zinc complexes are inhibitory not only for the NF-kappa B-DNA binding, but also for the binding of NF-kappa B with the inhibitory protein I kappa B. Discriminative inhibition of the DNA binding of two distinct C2H2 type zinc finger proteins HIV-EP1 and Sp1 was also attempted using the synthetic compounds.	Histidine	47-56	nuclear factor kappa B subunit 1	Homo sapiens	18-28
9043672-3	1997	Experiments using NF-kappa B-beads showed that histidine-pyridine-histidine compounds and their zinc complexes are inhibitory not only for the NF-kappa B-DNA binding, but also for the binding of NF-kappa B with the inhibitory protein I kappa B. Discriminative inhibition of the DNA binding of two distinct C2H2 type zinc finger proteins HIV-EP1 and Sp1 was also attempted using the synthetic compounds.	Histidine	47-56	nuclear factor kappa B subunit 1	Homo sapiens	143-153
9043672-3	1997	Experiments using NF-kappa B-beads showed that histidine-pyridine-histidine compounds and their zinc complexes are inhibitory not only for the NF-kappa B-DNA binding, but also for the binding of NF-kappa B with the inhibitory protein I kappa B. Discriminative inhibition of the DNA binding of two distinct C2H2 type zinc finger proteins HIV-EP1 and Sp1 was also attempted using the synthetic compounds.	Histidine	47-56	nuclear factor kappa B subunit 1	Homo sapiens	143-153
9043672-3	1997	Experiments using NF-kappa B-beads showed that histidine-pyridine-histidine compounds and their zinc complexes are inhibitory not only for the NF-kappa B-DNA binding, but also for the binding of NF-kappa B with the inhibitory protein I kappa B. Discriminative inhibition of the DNA binding of two distinct C2H2 type zinc finger proteins HIV-EP1 and Sp1 was also attempted using the synthetic compounds.	Histidine	47-56	HIVEP zinc finger 1	Homo sapiens	337-344
9117995-0	1997	Photo-oxidation of histidine as a probe for aminoterminal conformational changes during fibrinogen-fibrin conversion.	Histidine	19-28	fibrinogen beta chain	Homo sapiens	88-98
9117995-1	1997	Fibrinogen is known to become unclottable when irradiated with light in the presence of methylene blue, the loss of clottability being due to photo-oxidation of the histidine at position 16 of the B beta chain.	Histidine	165-174	fibrinogen beta chain	Homo sapiens	0-10
9104733-1	1997	Cyclo (His-Pro) or CHP is a cyclic dipeptide that is known to elicit many biologic activities including inhibition of pituitary prolactin (PRL) secretion.	Histidine	7-10	prolactin	Homo sapiens	128-137
9104733-1	1997	Cyclo (His-Pro) or CHP is a cyclic dipeptide that is known to elicit many biologic activities including inhibition of pituitary prolactin (PRL) secretion.	Histidine	7-10	prolactin	Homo sapiens	139-142
8975710-4	1996	The predicted human DYRK and murine Dyrk proteins both contain a nuclear targeting signal sequence, a protein kinase domain, a putative leucine zipper motif, and a highly conserved 13-consecutive-histidine repeat.	Histidine	196-205	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	20-24
9016654-4	1996	Like TIF1 alpha, TIF1 beta also contains an additional Cys/His cluster (PHD finger) and a bromo-related domain.	Histidine	59-62	tripartite motif containing 28	Homo sapiens	17-26
8961951-8	1996	Interestingly, the function in the human enzyme of this invariant histidine is distinct from its role in yeast transketolase in which it aids in binding donor substrate and in subsequent catalytic events.	Histidine	66-75	transketolase	Homo sapiens	111-124
8954946-2	1996	Using histidine-tagged TBP as a ligand for affinity-purification of proteins bound to TBP, we purified a 120-kD protein, termed TBP-interacting protein 120 (TIP120), from rat liver nuclear extracts.	Histidine	6-15	cullin-associated and neddylation-dissociated 1	Rattus norvegicus	128-155
8954946-2	1996	Using histidine-tagged TBP as a ligand for affinity-purification of proteins bound to TBP, we purified a 120-kD protein, termed TBP-interacting protein 120 (TIP120), from rat liver nuclear extracts.	Histidine	6-15	cullin-associated and neddylation-dissociated 1	Rattus norvegicus	157-163
8942679-0	1996	Active site structure in cytochrome c peroxidase and myoglobin mutants: effects of altered hydrogen bonding to the proximal histidine.	Histidine	124-133	cytochrome c, somatic	Homo sapiens	25-37
8986225-6	1996	Three different mutations were found in the exon 3 sequence of CCKBR: His (CAT) at aa207--&gt;His (CAC) (5.4%), Arg (CGC) at aa215--&gt;His (CAC) (4.5%), and Val (GTG) at aa138--&gt;Met (ATG) (0.9%) in controls.	Histidine	70-73	cholecystokinin B receptor	Homo sapiens	63-68
8986225-6	1996	Three different mutations were found in the exon 3 sequence of CCKBR: His (CAT) at aa207--&gt;His (CAC) (5.4%), Arg (CGC) at aa215--&gt;His (CAC) (4.5%), and Val (GTG) at aa138--&gt;Met (ATG) (0.9%) in controls.	Histidine	94-97	cholecystokinin B receptor	Homo sapiens	63-68
8986225-6	1996	Three different mutations were found in the exon 3 sequence of CCKBR: His (CAT) at aa207--&gt;His (CAC) (5.4%), Arg (CGC) at aa215--&gt;His (CAC) (4.5%), and Val (GTG) at aa138--&gt;Met (ATG) (0.9%) in controls.	Histidine	94-97	cholecystokinin B receptor	Homo sapiens	63-68
27406670-5	1996	A change in tyrosine at the 32 position in the heavy chain and histidine at position 27 of the light chain of the NQ11.7.22-Fv fragment results in a profound reduction in SOD-like activity.	Histidine	63-72	superoxide dismutase 1	Homo sapiens	171-174
8910515-6	1996	Consistent with this hypothesis, mutation of histidine 144 of t-PA to an acidic residue, as in u-PA, selectively suppressed the activity of single-chain t-PA and thereby significantly enhanced the enzyme"s zymogenicity.	Histidine	45-54	plasminogen activator, tissue type	Homo sapiens	62-66
8946953-0	1996	Ribonuclease A mutant His119 Asn: the role of histidine in catalysis.	Histidine	46-55	ribonuclease pancreatic	Bos taurus	0-14
8910515-6	1996	Consistent with this hypothesis, mutation of histidine 144 of t-PA to an acidic residue, as in u-PA, selectively suppressed the activity of single-chain t-PA and thereby significantly enhanced the enzyme"s zymogenicity.	Histidine	45-54	plasminogen activator, urokinase	Homo sapiens	95-99
8910515-6	1996	Consistent with this hypothesis, mutation of histidine 144 of t-PA to an acidic residue, as in u-PA, selectively suppressed the activity of single-chain t-PA and thereby significantly enhanced the enzyme"s zymogenicity.	Histidine	45-54	plasminogen activator, tissue type	Homo sapiens	153-157
8930408-0	1996	Directed mutagenesis reveals that two histidines in tissue inhibitor of metalloproteinase-1 are each essential for the suppression of cell migration, invasion, and tumorigenicity.	Histidine	38-48	tissue inhibitor of metalloproteinase 1	Mus musculus	52-91
8910407-3	1996	Here we describe the application of highly specific tandem mass spectrometric techniques to the first characterization of lipid-modified LDL by demonstrating the addition of 4-hydroxy-2-nonenal to histidine residues of apolipoprotein B-100, following oxidation of LDL.	Histidine	197-206	apolipoprotein B	Homo sapiens	219-239
8841129-3	1996	We have characterized site-directed mutants of the photosystem I reaction center protein PsaB and identified an amino acid, His-656, that interacts closely with one of the P700 chlorophylls.	Histidine	124-127	fatty acid amide hydrolase	Homo sapiens	89-93
8902538-4	1996	It was also shown that the old Cu/Zn-SOD had one histidine fewer than the young one.	Histidine	49-58	superoxide dismutase 1	Rattus norvegicus	31-40
8810317-1	1996	We have examined in detail the DNA binding properties of several immunopurified tumor-derived mutant p53 proteins (Val-143 --&gt; Ala, Arg-175 --&gt; His, Arg-248 --&gt; Trp, Arg-249 --&gt; Ser, and Arg-273 --&gt; His).	Histidine	150-153	tumor protein p53	Homo sapiens	101-104
8810317-1	1996	We have examined in detail the DNA binding properties of several immunopurified tumor-derived mutant p53 proteins (Val-143 --&gt; Ala, Arg-175 --&gt; His, Arg-248 --&gt; Trp, Arg-249 --&gt; Ser, and Arg-273 --&gt; His).	Histidine	214-217	tumor protein p53	Homo sapiens	101-104
8828460-3	1996	Two TR beta mutations were newly found in patients with RTH at codon 435 histidine (H435L and H435Q) close to the dimerization region.	Histidine	73-82	T cell receptor beta locus	Homo sapiens	4-11
8805707-6	1996	The structure reveals a fold that has not been reported for any other serine protease, and an active site consisting of a novel catalytic triad in which the third member is a histidine instead of an aspartic acid, or possibly a catalytic tetrad consisting of a serine, two histidines and an aspartic acid.	Histidine	175-184	coagulation factor II, thrombin	Homo sapiens	70-85
8828480-6	1996	PTH and PTHrP differ in several positions, including position 5 (Ile in PTH; His in PTHrP).	Histidine	77-80	parathyroid hormone	Homo sapiens	0-3
8828480-6	1996	PTH and PTHrP differ in several positions, including position 5 (Ile in PTH; His in PTHrP).	Histidine	77-80	parathyroid hormone	Homo sapiens	8-11
8816462-11	1996	In this report, we describe the identification and biochemical characterization of mutations in the amino-terminal cysteine- and histidine-rich region of Upf1p that have normal nonsense-mediated mRNA decay activities but are able to suppress leu2-2 and tyr7-1 nonsense alleles.	Histidine	129-138	3-isopropylmalate dehydrogenase	Saccharomyces cerevisiae S288C	242-248
8843163-6	1996	These findings suggest that both histidine 57 and histidine 121, which are conserved in the rat, rabbit and human PEPT1, are involved in substrate recognition of this molecule.	Histidine	33-42	solute carrier family 15 member 1	Homo sapiens	114-119
8843163-6	1996	These findings suggest that both histidine 57 and histidine 121, which are conserved in the rat, rabbit and human PEPT1, are involved in substrate recognition of this molecule.	Histidine	50-59	solute carrier family 15 member 1	Homo sapiens	114-119
8848049-2	1996	In rhodopsin, the photoreceptor of retinal rod cells, we substituted histidine residues for natural amino acids at the cytoplasmic ends of the TM helices C and F. The resulting mutant proteins were able to activate the visual G protein transducin in the absence but not in the presence of metal ions.	Histidine	69-78	rhodopsin	Homo sapiens	3-12
8805707-6	1996	The structure reveals a fold that has not been reported for any other serine protease, and an active site consisting of a novel catalytic triad in which the third member is a histidine instead of an aspartic acid, or possibly a catalytic tetrad consisting of a serine, two histidines and an aspartic acid.	Histidine	273-283	coagulation factor II, thrombin	Homo sapiens	70-85
8794740-12	1996	However, a double mutant of CA V containing the two replacements, Tyr 64--&gt;His and Phe 65--&gt;Ala, demonstrated enhanced proton transfer with an apparent pKa of 6.8 and maximal contribution to kcat of 2.2 x 10(5) s-1.	Histidine	78-81	carbonic anhydrase 5a, mitochondrial	Mus musculus	28-32
8702701-5	1996	The results showed that two sites in PTH and PTHrP fully account for the different potencies that the two ligands exhibited with PTH-2 receptors; residue 5 (His in PTHrP and Ile in PTH) determined signaling capability, while residue 23 (Phe in PTHrP and Trp in PTH) determined binding affinity.	Histidine	157-160	parathyroid hormone	Homo sapiens	37-40
8781408-9	1996	However, the binding of BCR/abl to p85 SH2 domains was abolished in cells expressing mutant, temperature-sensitive (ts) p210 BCR/abl in which the tyrosine in the YXXM motif of p210 BCR/abl was replaced by histidine.	Histidine	205-214	BCR activator of RhoGEF and GTPase	Mus musculus	24-27
8781408-9	1996	However, the binding of BCR/abl to p85 SH2 domains was abolished in cells expressing mutant, temperature-sensitive (ts) p210 BCR/abl in which the tyrosine in the YXXM motif of p210 BCR/abl was replaced by histidine.	Histidine	205-214	extracellular matrix protein 1	Mus musculus	35-38
8756655-1	1996	Human wild-type (wt) p53 can induce apoptosis in transiently transfected H1299 cells maintained at 37 degrees C, whereas tumor-derived mutant forms of p53 (with the mutation Ala-143, His-175, or Trp-248) fail to do so.	Histidine	183-186	tumor protein p53	Homo sapiens	151-154
21143275-6	1996	Agonist activity of AngII also requires an interaction of the Phe(2) side chain with His(256), which is achieved by docking of the alpha-COOH with Lys(199).	Histidine	85-88	angiotensinogen	Rattus norvegicus	20-25
21143275-13	1996	Asp(1) of AngII forms an ion-pair with His(183), which stabilizes the receptor-bound conformation of AngII but is not critical for receptor activation.	Histidine	39-42	angiotensinogen	Rattus norvegicus	10-15
21143275-13	1996	Asp(1) of AngII forms an ion-pair with His(183), which stabilizes the receptor-bound conformation of AngII but is not critical for receptor activation.	Histidine	39-42	angiotensinogen	Rattus norvegicus	101-106
8817875-1	1996	Angiotensin-converting enzyme (ACE; EN 3.4.15.1) is a peptidyl dipeptide hydrolase that removes the carboxyl terminal His-Leu from angiotensin I to produce the octapeptide angiotensin II.	Histidine	118-121	angiotensin I converting enzyme	Homo sapiens	0-29
8817875-1	1996	Angiotensin-converting enzyme (ACE; EN 3.4.15.1) is a peptidyl dipeptide hydrolase that removes the carboxyl terminal His-Leu from angiotensin I to produce the octapeptide angiotensin II.	Histidine	118-121	angiotensin I converting enzyme	Homo sapiens	31-34
8817875-1	1996	Angiotensin-converting enzyme (ACE; EN 3.4.15.1) is a peptidyl dipeptide hydrolase that removes the carboxyl terminal His-Leu from angiotensin I to produce the octapeptide angiotensin II.	Histidine	118-121	angiotensinogen	Homo sapiens	131-144
8817875-1	1996	Angiotensin-converting enzyme (ACE; EN 3.4.15.1) is a peptidyl dipeptide hydrolase that removes the carboxyl terminal His-Leu from angiotensin I to produce the octapeptide angiotensin II.	Histidine	118-121	angiotensinogen	Homo sapiens	172-186
8718890-9	1996	A model is presented for a prereaction complex of myeloperoxidase in which hydrogen peroxide is hydrogen bonded to the distal histidine, as a prerequisite for deprotonation and subsequent binding at the sixth coordination site of the heme iron.	Histidine	126-135	myeloperoxidase	Homo sapiens	50-65
8702701-5	1996	The results showed that two sites in PTH and PTHrP fully account for the different potencies that the two ligands exhibited with PTH-2 receptors; residue 5 (His in PTHrP and Ile in PTH) determined signaling capability, while residue 23 (Phe in PTHrP and Trp in PTH) determined binding affinity.	Histidine	157-160	parathyroid hormone	Homo sapiens	45-48
8702701-5	1996	The results showed that two sites in PTH and PTHrP fully account for the different potencies that the two ligands exhibited with PTH-2 receptors; residue 5 (His in PTHrP and Ile in PTH) determined signaling capability, while residue 23 (Phe in PTHrP and Trp in PTH) determined binding affinity.	Histidine	157-160	parathyroid hormone	Homo sapiens	45-48
8753810-4	1996	Substitution of Cys-16, Cys-31, or His-33 markedly decreased the transforming activity of Rfp/Ret.	Histidine	35-38	ret proto-oncogene	Mus musculus	94-97
8753810-6	1996	In contrast, mutations of Cys-118 or His-124 in the second cysteine/histidine-rich motif (called B box) of Rfp/Ret did not affect its activity.	Histidine	37-40	ret proto-oncogene	Mus musculus	111-114
8753810-6	1996	In contrast, mutations of Cys-118 or His-124 in the second cysteine/histidine-rich motif (called B box) of Rfp/Ret did not affect its activity.	Histidine	68-77	ret proto-oncogene	Mus musculus	111-114
8692902-6	1996	The basic motif of these newt MMP genes was similar to mammalian counterparts and contained regions encoding a putative signal sequence, a propeptide, an active site with three zinc-binding histidine residues, a calcium-binding domain, a hemopexin region, and three key cysteine residues.	Histidine	190-199	matrix metallopeptidase 3	Homo sapiens	30-33
8761428-5	1996	Furthermore, the enzymatic activity of 10-formyltetrahydrofolate dehydrogenase, the terminal enzyme in the catabolism of the ring-2-carbon of histidine to CO2, was diminished by 32% in methotrexate-treated animals.	Histidine	142-151	aldehyde dehydrogenase 1 family, member L1	Rattus norvegicus	39-78
8713077-5	1996	It was estimated that 2 mol of histidine residues per mol of enzyme were responsible for the loss of catalytic activity, as deduced from the correlation of the difference spectrum at 240 nm of the DEP-modified cGI-PDE with the enzyme activity.	Histidine	31-40	phosphodiesterase 3A	Homo sapiens	210-217
8713077-7	1996	AMP protects the enzyme against DEP, NEM and DTNB, suggesting the presence of histidine and cysteine residues at the active site of cGI-PDE.	Histidine	78-87	phosphodiesterase 3A	Homo sapiens	132-139
8713077-11	1996	We conclude that cGI-PDE possesses two essential histidine residues for activity, two additional histidines for cGMP inhibition, and one cysteine residue at the active site.	Histidine	49-58	phosphodiesterase 3A	Homo sapiens	17-24
8713077-11	1996	We conclude that cGI-PDE possesses two essential histidine residues for activity, two additional histidines for cGMP inhibition, and one cysteine residue at the active site.	Histidine	97-107	phosphodiesterase 3A	Homo sapiens	17-24
8665492-3	1996	Only 1/45 samples showed the incidence of a homozygous mutation at codon 179 (exon 5) of the p53 gene that replaces histidine with tyrosine.	Histidine	116-125	tumor protein p53	Homo sapiens	93-96
8864848-0	1996	Conserved histidine residues of RCC1 are essential for nucleotide exchange on Ran.	Histidine	10-19	regulator of chromosome condensation	Mesocricetus auratus	32-36
8864848-0	1996	Conserved histidine residues of RCC1 are essential for nucleotide exchange on Ran.	Histidine	10-19	GTP-binding nuclear protein Ran	Mesocricetus auratus	78-81
8864848-5	1996	In contrast, mutants containing the conserved histidine residues in the C-terminus of the RCC1 repeat showed a value of K(m) similar to that of wild-type RCC1, while the kcat values of these mutants were reduced, depending upon the RCC1 repeats on which the mutation was located.	Histidine	46-55	regulator of chromosome condensation	Mesocricetus auratus	90-94
8864848-5	1996	In contrast, mutants containing the conserved histidine residues in the C-terminus of the RCC1 repeat showed a value of K(m) similar to that of wild-type RCC1, while the kcat values of these mutants were reduced, depending upon the RCC1 repeats on which the mutation was located.	Histidine	46-55	regulator of chromosome condensation	Mesocricetus auratus	154-158
8864848-5	1996	In contrast, mutants containing the conserved histidine residues in the C-terminus of the RCC1 repeat showed a value of K(m) similar to that of wild-type RCC1, while the kcat values of these mutants were reduced, depending upon the RCC1 repeats on which the mutation was located.	Histidine	46-55	regulator of chromosome condensation	Mesocricetus auratus	154-158
8864848-7	1996	The comparison of kcat among the histidine mutants suggests that those histidine residues which are conserved in the RCC1 repeats and also through evolution comprise the catalytic site for the guanine nucleotide exchange reaction.	Histidine	33-42	regulator of chromosome condensation	Mesocricetus auratus	117-121
8864848-7	1996	The comparison of kcat among the histidine mutants suggests that those histidine residues which are conserved in the RCC1 repeats and also through evolution comprise the catalytic site for the guanine nucleotide exchange reaction.	Histidine	71-80	regulator of chromosome condensation	Mesocricetus auratus	117-121
8621599-6	1996	Using peptides corresponding to J-domain sequence, we show that a peptide containing the highly conserved His-Pro-Asp sequence at positions 34-36 in the J-domain competes off YDJ1 stimulation of Hsp70 ATPase activity.	Histidine	106-109	type I HSP40 co-chaperone YDJ1	Saccharomyces cerevisiae S288C	175-179
8649776-2	1996	By using recombination PCR in vitro mutagenesis, we introduced point mutations into the codon 273 of wild-type (wt) p53 (pC53-SN3) from Arg to His (pC53-273H [273H]), Asp (273D), Pro (273P), Lys (273K), Leu (273L) or Thr (273T), and compared their biological and biochemical activities with wt p53 and cancer-derived 175H, 248W and 273H/309S.	Histidine	143-146	tumor protein p53	Homo sapiens	116-119
8766941-1	1996	A clinical, prospective experiment was carried out to determine whether long-term intranasal administration of the growth hormone-releasing peptide hexarelin (His-D-2-methyl-Trp-Ala-Trp-D-Phe -Lys-NH2) affects pituitary growth hormone secretion.	Histidine	159-162	growth hormone 1	Homo sapiens	115-129
8836769-10	1996	A dipeptide His-Leu carboxy-extension form of AII, angiotensin I (AI), only bound to anti-AII abs at 100-200 times higher concentrations, showing that the C-terminal epitope was blocked by the dipeptide.	Histidine	12-15	angiotensinogen	Homo sapiens	46-49
8836769-10	1996	A dipeptide His-Leu carboxy-extension form of AII, angiotensin I (AI), only bound to anti-AII abs at 100-200 times higher concentrations, showing that the C-terminal epitope was blocked by the dipeptide.	Histidine	12-15	angiotensinogen	Homo sapiens	51-64
8836769-10	1996	A dipeptide His-Leu carboxy-extension form of AII, angiotensin I (AI), only bound to anti-AII abs at 100-200 times higher concentrations, showing that the C-terminal epitope was blocked by the dipeptide.	Histidine	12-15	angiotensinogen	Homo sapiens	90-93
8647124-6	1996	Saturation of the binding sites with [3H]propionyl-CCK8 revealed Kd values of 4.5 +/- 0.5 nM and 7.8 +/- 0.6 nM for the CCKB receptor without or with histidine tag.	Histidine	150-159	cholecystokinin B receptor	Homo sapiens	120-124
8647124-7	1996	In SDS/PAGE and subsequent immunodetection the histidine-tagged CCKB receptor migrated as a 55-kDa band, whereas the CCKB receptor without C-terminal modification revealed apparent molecular masses of 45 kDa and 49 kDa.	Histidine	47-56	cholecystokinin B receptor	Homo sapiens	64-68
8647124-8	1996	The differences in the mass values observed for the two constructs suggest that the histidine tag could protect the CCKB receptor against proteolytical degradation from its C-terminus.	Histidine	84-93	cholecystokinin B receptor	Homo sapiens	116-120
8647124-14	1996	The solubilized CCKB receptors with C-terminal histidine tag retained their ligand binding characteristics after chromatography on a nickel affinity matrix.	Histidine	47-56	cholecystokinin B receptor	Homo sapiens	16-20
8679537-3	1996	First, His64(E7) to Gly and Ala mutations, which open a direct channel from the solvent to the iron atom, and Phe46(CD4) to Leu, Ile, and Val mutations, which increase the mobility of the distal histidine, have little effect on the association rate constant for cyanide binding.	Histidine	195-204	CD4 molecule	Homo sapiens	116-119
8828797-2	1996	To apply R-NSE to RIA and to simplify the purification procedure, the N- and C-terminals of R-NSE were modified by tyrosine- and histidine-tagging, respectively.	Histidine	129-138	enolase 2	Homo sapiens	94-97
8638957-7	1996	The transcript of the integrated CYP3A7 gene possessed the ability to activate aflatoxin B1 in Ames test in which the his+ revertants of Salmonella typhimurium TA100 per plate were significantly higher (P &lt; 0.01) when liver microsomes of line M10 transgenic mice were used.	Histidine	118-121	cytochrome P450 family 3 subfamily A member 7	Homo sapiens	33-39
8743954-4	1996	Here we have expressed a full-length human cyclin A in Escherichia coli and purified the protein to homogeneity by virtue of an N-terminal histidine tag.	Histidine	139-148	cyclin A2	Homo sapiens	43-51
8664285-6	1996	His-1-Glu-282 was as effective as intact soluble GP Ibalpha (glycocalicin) in inhibiting botrocetin-dependent binding of vWF to washed platelets (IC50 approximately 0.3 microM) whereas His-1-Leu-275 was an order of magnitude less effective (IC50 approximately 3 microM).	Histidine	0-3	von Willebrand factor	Homo sapiens	121-124
8664285-16	1996	These findings indicate that the sulfated tyrosine/anionic GP Ibalpha residues Tyr-276-Glu-282 are important for the binding of thrombin and botrocetin-dependent binding of thrombin and the botrocetin-dependent binding of vWF, but that vWF also interacts with residues within His-1-Leu-275.	Histidine	276-279	coagulation factor II, thrombin	Homo sapiens	128-136
8617223-3	1996	It resembles ZnT-1 (a plasma membrane protein that stimulates zinc efflux) in overall topology in that it has six membrane-spanning domains, a histidine-rich intracellular loop and a long C-terminal tail; however, the overall amino acid identity is only 26%.	Histidine	143-152	solute carrier family 30 member 1	Homo sapiens	13-18
8664285-8	1996	In ligand blot analysis, thrombin blotted the His-1-Glu-282 fragment, but not His-1-Leu-275.	Histidine	46-49	coagulation factor II, thrombin	Homo sapiens	25-33
8664285-16	1996	These findings indicate that the sulfated tyrosine/anionic GP Ibalpha residues Tyr-276-Glu-282 are important for the binding of thrombin and botrocetin-dependent binding of thrombin and the botrocetin-dependent binding of vWF, but that vWF also interacts with residues within His-1-Leu-275.	Histidine	276-279	coagulation factor II, thrombin	Homo sapiens	173-181
8664285-16	1996	These findings indicate that the sulfated tyrosine/anionic GP Ibalpha residues Tyr-276-Glu-282 are important for the binding of thrombin and botrocetin-dependent binding of thrombin and the botrocetin-dependent binding of vWF, but that vWF also interacts with residues within His-1-Leu-275.	Histidine	276-279	von Willebrand factor	Homo sapiens	222-225
8664285-16	1996	These findings indicate that the sulfated tyrosine/anionic GP Ibalpha residues Tyr-276-Glu-282 are important for the binding of thrombin and botrocetin-dependent binding of thrombin and the botrocetin-dependent binding of vWF, but that vWF also interacts with residues within His-1-Leu-275.	Histidine	276-279	von Willebrand factor	Homo sapiens	236-239
8672427-0	1996	Site-directed mutagenesis of residues in a conserved region of bovine aspartyl (asparaginyl) beta-hydroxylase: evidence that histidine 675 has a role in binding Fe2+.	Histidine	125-134	aspartate beta-hydroxylase	Bos taurus	70-109
8621548-5	1996	In addition, p300 is able to interact both in vivo and in vitro with MyoD through a portion at the carboxyl-terminal cysteine/histidine-rich domain and associates with the components of the basal transcriptional complex through its two separate transactivation domains at the amino and carboxyl termini.	Histidine	126-135	myogenic differentiation 1	Homo sapiens	69-73
8605210-0	1996	Active site of bee venom phospholipase A2: the role of histidine-34, aspartate-64 and tyrosine-87.	Histidine	55-64	phospholipase A2 group IB	Homo sapiens	25-41
8605210-1	1996	In bee venom phospholipase A2, histidine-34 probably functions as a Bronsted base to deprotonate the attacking water.	Histidine	31-40	phospholipase A2 group IB	Homo sapiens	13-29
8638944-4	1996	As expected, the hepatic activities of a number of enzymes involved in the catabolism of histidine to CO2 were markedly decreased in hyperthyroid (histidase, 69%; urocanase, 30%; 10-formyltetrahydrofolate dehydrogenase, 65%) and folate-restricted (10-formyltetrahydrofolate dehydrogenase, 44%) rats.	Histidine	89-98	histidine ammonia lyase	Rattus norvegicus	147-156
8967341-3	1996	JNK1 (p45) and JNK2 (p54) isoforms phosphorylated His-c-jun in mesangial cells.	Histidine	50-53	mitogen-activated protein kinase 8	Homo sapiens	0-4
8967341-3	1996	JNK1 (p45) and JNK2 (p54) isoforms phosphorylated His-c-jun in mesangial cells.	Histidine	50-53	caspase 1	Homo sapiens	6-9
8967341-3	1996	JNK1 (p45) and JNK2 (p54) isoforms phosphorylated His-c-jun in mesangial cells.	Histidine	50-53	mitogen-activated protein kinase 9	Homo sapiens	15-19
8638944-4	1996	As expected, the hepatic activities of a number of enzymes involved in the catabolism of histidine to CO2 were markedly decreased in hyperthyroid (histidase, 69%; urocanase, 30%; 10-formyltetrahydrofolate dehydrogenase, 65%) and folate-restricted (10-formyltetrahydrofolate dehydrogenase, 44%) rats.	Histidine	89-98	aldehyde dehydrogenase 1 family, member L1	Rattus norvegicus	179-218
8638944-4	1996	As expected, the hepatic activities of a number of enzymes involved in the catabolism of histidine to CO2 were markedly decreased in hyperthyroid (histidase, 69%; urocanase, 30%; 10-formyltetrahydrofolate dehydrogenase, 65%) and folate-restricted (10-formyltetrahydrofolate dehydrogenase, 44%) rats.	Histidine	89-98	aldehyde dehydrogenase 1 family, member L1	Rattus norvegicus	248-287
8652624-2	1996	Insertion of histidine and glycine at positions 77 and 78 in bovine MBP greatly reduces the encephalitogenicity of the protein.	Histidine	13-22	myelin basic protein	Bos taurus	68-71
8615762-3	1996	PC8 possessed the catalytically important Asp, His, Asn and Ser amino acids, the homo B domain of this family of enzymes and a C-terminal hydrophobic sequence indicative of a transmembrane domain.	Histidine	47-50	proprotein convertase subtilisin/kexin type 7	Homo sapiens	0-3
8601452-0	1996	Chemical modification of porcine kidney aminopeptidase P indicates the involvement of two critical histidine residues.	Histidine	99-108	amyloid beta precursor protein	Homo sapiens	40-56
8598290-3	1996	We show that in a sin4 mutant such suppression is incompletely penetrant, such that genetically identical yeast cells (sin4 his4-912delta) show either of two distinct phenotypic states, His+ or His-.	Histidine	194-197	trifunctional histidinol dehydrogenase/phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase	Saccharomyces cerevisiae S288C	124-128
8638712-8	1996	We concluded that gastrin, acting through "gastrin/CCK-B type" receptors coupled to PTX-sensitive G protein, exerts a short-term regulation of histamine synthesis in gastric ECL cells by increasing both the affinity of HDC for L-histidine and the number of active enzyme molecules.	Histidine	227-238	gastrin	Oryctolagus cuniculus	18-25
8638712-8	1996	We concluded that gastrin, acting through "gastrin/CCK-B type" receptors coupled to PTX-sensitive G protein, exerts a short-term regulation of histamine synthesis in gastric ECL cells by increasing both the affinity of HDC for L-histidine and the number of active enzyme molecules.	Histidine	227-238	gastrin	Oryctolagus cuniculus	43-50
8598290-3	1996	We show that in a sin4 mutant such suppression is incompletely penetrant, such that genetically identical yeast cells (sin4 his4-912delta) show either of two distinct phenotypic states, His+ or His-.	Histidine	186-189	Sin4p	Saccharomyces cerevisiae S288C	18-22
8598290-3	1996	We show that in a sin4 mutant such suppression is incompletely penetrant, such that genetically identical yeast cells (sin4 his4-912delta) show either of two distinct phenotypic states, His+ or His-.	Histidine	186-189	Sin4p	Saccharomyces cerevisiae S288C	119-123
8598290-3	1996	We show that in a sin4 mutant such suppression is incompletely penetrant, such that genetically identical yeast cells (sin4 his4-912delta) show either of two distinct phenotypic states, His+ or His-.	Histidine	186-189	trifunctional histidinol dehydrogenase/phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase	Saccharomyces cerevisiae S288C	124-128
8547652-3	1996	Sequencing of the whole coding region of the c-kit showed that the point mutation found in HMC-1, P-815, and RBL-2H3 cells was absent in FMA3 cells and that the c-kit cDNA of FMA3 cells carried an in-frame deletion of 21 base pairs (bp) encoding Thr-Gln-Leu-Pro-Tyr-Asp-His at codons 573 to 579 at the juxtamembrane domain.	Histidine	270-273	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	45-50
8598290-3	1996	We show that in a sin4 mutant such suppression is incompletely penetrant, such that genetically identical yeast cells (sin4 his4-912delta) show either of two distinct phenotypic states, His+ or His-.	Histidine	194-197	Sin4p	Saccharomyces cerevisiae S288C	18-22
8598290-3	1996	We show that in a sin4 mutant such suppression is incompletely penetrant, such that genetically identical yeast cells (sin4 his4-912delta) show either of two distinct phenotypic states, His+ or His-.	Histidine	194-197	Sin4p	Saccharomyces cerevisiae S288C	119-123
8617783-7	1996	The metal chelating abilities of these histidine mutants of thioredoxin were successfully utilized for convenient purifications of human interleukin-8 and -11 expressed in E. coli as soluble thioredoxin fusion proteins.	Histidine	39-48	C-X-C motif chemokine ligand 8	Homo sapiens	137-158
8833655-9	1996	Human PRL must have two types of interactions with Zn++; one is binding to a site involving histidine 27, and the other is weaker interactions that induce self-association of PRL.	Histidine	92-101	prolactin	Homo sapiens	6-9
8558519-3	1996	Previously we have reported zinc chelators having histidine--pyridine--histidine skeleton and were successful in inhibiting the DNA binding of HIV-EP1 by removing zinc from the zinc finger domain.	Histidine	50-59	HIVEP zinc finger 1	Homo sapiens	143-150
8558519-7	1996	It appeared that these inhibited the DNA binding of HIV-EP1 by a mechanism distinct from that of the previous histidine-based inhibitors.	Histidine	110-119	HIVEP zinc finger 1	Homo sapiens	52-59
8621385-4	1996	Comparison of experimental results for scFv 9-40/212 with its mutant scFv 9-40/212Arg-34L indicated that the pH dependence of mAb 9-40 was due to the titration of His-34L in the active site.	Histidine	163-166	immunglobulin heavy chain variable region	Homo sapiens	39-43
8621385-4	1996	Comparison of experimental results for scFv 9-40/212 with its mutant scFv 9-40/212Arg-34L indicated that the pH dependence of mAb 9-40 was due to the titration of His-34L in the active site.	Histidine	163-166	immunglobulin heavy chain variable region	Homo sapiens	69-73
8745399-5	1996	Although PPACK forms covalent bonds to both serine and the histidine of the catalytic triad of thrombin, neither BMS-186282 nor BMS-189090 bind covalently and only BMS-186282 forms a hydrogen bond to the serine of the catalytic triad.	Histidine	59-68	coagulation factor II, thrombin	Homo sapiens	95-103
8745400-2	1996	It is known that in TIM, three residues, Lys 13 (loop 1), His 95 (loop 4), and Glu 167 (loop 6) are the crucial catalytic residues.	Histidine	58-61	triosephosphate isomerase 1	Homo sapiens	20-23
8800477-3	1996	Two X-ray structures of soybean lipoxygenase-1 reveal the side chains of three histidines and the COO- of the carboxy terminus as ligands to the catalytically important iron atom.	Histidine	79-89	seed linoleate 13S-lipoxygenase-1	Glycine max	32-46
9575343-4	1996	In contrast, the corresponding S1 pocket of hCG is large and accepts the positively charged "aromatic" side chain of histidine, which increases most significantly the capability of CRP derived inhibitors.	Histidine	117-126	C-reactive protein	Homo sapiens	181-184
8825870-4	1996	The histidine B10 to aspartic acid mutation creates a more stable form of insulin leading to an increase in insulin accumulation.	Histidine	4-13	insulin	Homo sapiens	74-81
8747529-0	1996	Fibrinogen Claro--another dysfunctional fibrinogen variant with gamma 275 arginine--&gt;histidine substitution.	Histidine	88-97	fibrinogen beta chain	Homo sapiens	0-10
8899819-2	1996	Ac-Ser.Tyr-Ser-Nle4-Glu- His-DPhe7-Arg-Trp-Gly-Lys-Pro-Val-NH2(NDP-MSH), led to the discovery of tripeptide agonists possessing prolonged bioactivity in the frog skin assay.	Histidine	25-28	proopiomelanocortin	Homo sapiens	67-70
12237699-4	1996	Using (35)S radiolabeling methods in vivo, we found that even at low temperature the expression of sigma(32)-6 His may markedly increase the synthesis of the heat shock proteins such as GroEL, Dnak, and HtpH.	Histidine	111-114	GroEL	Escherichia coli	186-191
8747529-0	1996	Fibrinogen Claro--another dysfunctional fibrinogen variant with gamma 275 arginine--&gt;histidine substitution.	Histidine	88-97	fibrinogen beta chain	Homo sapiens	40-50
7493993-3	1995	A (2-amino-4-thiazolyl)methyl side chain at the P2 position shows stronger hydrogen-bonding and van der Waals interactions with renin than the His side chain, which is present in the natural substrate.	Histidine	143-146	renin	Homo sapiens	128-133
8530370-8	1995	We therefore constructed Fc alpha R molecules where Arg209 was mutated to either a positively charged histidine, a negatively charged aspartic acid, or an uncharged leucine.	Histidine	102-111	Fc alpha receptor	Homo sapiens	25-35
8869636-4	1995	Histidine residues also sit at the monomer-monomer interfaces of the trimer and are likely to contribute to the decreased solubility of cocoa vicilin at mild acidic pH, which is generally considered to be caused solely by aggregation near to the isoelectric point.	Histidine	0-9	vicilin	Theobroma cacao	142-149
7479916-3	1995	In the prototypical isozyme, carbonic anhydrase II, catalytic proton transfer occurs via the shuttle group His-64; carbonic anhydrase V has Tyr-64, which is not an efficient proton shuttle due in part to the bulky adjacent side chain of Phe-65.	Histidine	107-110	carbonic anhydrase 2	Mus musculus	29-50
7566022-8	1995	RESULTS: The patient was homozygous for a point mutation that replaces histidine (CAT) with glutamine (CAG) at position 101 of the gene for the alpha-tocopherol-transfer protein.	Histidine	71-80	catalase	Homo sapiens	82-85
8529662-4	1995	Sequence analysis showed that ERp57/GRP58 has two Trp-Cys-Gly-His-Cys-Lys motifs completely conserved among the mammals.	Histidine	62-65	protein disulfide isomerase family A member 3	Homo sapiens	30-35
8529662-4	1995	Sequence analysis showed that ERp57/GRP58 has two Trp-Cys-Gly-His-Cys-Lys motifs completely conserved among the mammals.	Histidine	62-65	protein disulfide isomerase family A member 3	Homo sapiens	36-41
8749307-0	1995	Identification of the reactive histidine of cucumisin, a plant serine protease: modification with peptidyl chloromethyl ketone derivative of peptide substrate.	Histidine	31-40	coagulation factor II, thrombin	Homo sapiens	63-78
9383482-3	1995	A polypeptide representing the relevant sequence from the alpha-subunit of the nAChR (Ac-Tyr-Cys-Glu-Ile-Ile-Val-Thr-His-Phe-Pro-Phe-Asp-Gln-Gln Asn-Cys-Thr-NH2) is small enough to allow detailed structural analysis, which may provide insight into the role of glycosylation in the maturation process that leads to ion-channel assembly.	Histidine	117-120	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	79-84
7593423-1	1995	GH-releasing peptide (GHRP-6; His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) is a synthetic compound that releases GH in a specific and dose-related manner through mechanisms and a point of action that are mostly unknown, but different from those of GHRH.	Histidine	30-33	growth hormone 1	Homo sapiens	0-2
7593423-1	1995	GH-releasing peptide (GHRP-6; His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) is a synthetic compound that releases GH in a specific and dose-related manner through mechanisms and a point of action that are mostly unknown, but different from those of GHRH.	Histidine	30-33	growth hormone releasing hormone	Homo sapiens	236-240
7492584-5	1995	The semi-purified HISAT showed a strict substrate specificity for L-histidine (and its methyl derivatives) and acetylcoenzyme A (CoASAc).	Histidine	66-77	histidine N-acetyltransferase	Oreochromis niloticus	18-23
7589519-5	1995	Inactivation "in vitro" of purified commercial bovine erythrocyte Cu/Zn-SOD led to a decrease in the enzymatic activity, an increase in the CO and one histidine residue modified.	Histidine	151-160	superoxide dismutase 1	Rattus norvegicus	66-75
8713746-6	1995	While dimethyl sulfoxide (DMSO) (up to 500 mM) and alpha-tocopherol (1 mM) inhibited the TNF induced inhibition of rate of loss of TEMPO decay, superoxide dismutase (SOD) (100 U/ml), catalase (1000 U/ml), and histidine (6 mM) had little effect on the TEMPO decay rate.	Histidine	209-218	tumor necrosis factor	Mus musculus	89-92
8566167-0	1995	The effect of hydrogen peroxide/L-histidine-induced DNA single- vs. double-strand breaks on poly(ADP-ribose)polymerase.	Histidine	32-43	poly(ADP-ribose) polymerase 1	Homo sapiens	92-118
8557169-3	1995	The proprotein convertases are all dependent on calcium for activity and all possess highly conserved subtilisin-like domains with the characteristic catalytic triad of this serine protease (ordered Asp, His, and Ser along the polypeptide chain).	Histidine	204-207	coagulation factor II, thrombin	Homo sapiens	174-189
7573557-2	1995	A peptide with substance P-like immunoreactivity was isolated from an extract of bowfin stomach and its primary structure was established as Ser-Lys-Ser-His-Gln-Phe-Tyr-Gly-Leu-Met-NH2.	Histidine	153-156	tachykinin precursor 1	Homo sapiens	15-26
7665554-1	1995	P-glycoprotein containing 10 tandem histidine residues at the COOH end of the molecule was transiently expressed in HEK 293 cells and purified by nickel-chelate chromatography.	Histidine	36-45	ATP binding cassette subfamily B member 1	Homo sapiens	0-14
7669042-3	1995	L-histidine dose-dependently increased insulin secretion and suppressed DNA synthesis without affecting the islet insulin content.	Histidine	0-11	insulin	Homo sapiens	39-46
7669042-6	1995	The present results suggest that exogenously added L-histidine, but not histamine, stimulates insulin secretion whereas both substances suppress beta-cell growth.	Histidine	51-62	insulin	Homo sapiens	94-101
7584623-1	1995	Pyroglutamate aminopeptidase type II is a highly specific membrane-bound neuropeptidase that has the ability to remove N-terminal pyroglutamate (Glp) from Thyrotropin Releasing Hormone (Glp-His-Pro-NH2) or very closely related tripeptides or tripeptide amides.	Histidine	190-193	thyrotropin releasing hormone	Bos taurus	155-184
7670940-6	1995	In the Finnish population, allele frequencies of the rare alleles of the apoB 1887 (Asn-->Ser) and apoB 1896 (His-->Arg) polymorphisms were .02 and .11, respectively.	Histidine	110-113	apolipoprotein B	Homo sapiens	99-103
7556217-4	1995	It belongs to the sulfakinin family, all known members of which (from flies, cockroaches and locusts) have the C-terminal heptapeptide sequence Asp-Tyr(SO3)-Gly-His-Met-Arg-Phe-NH2.	Histidine	161-164	Drosulfakinin	Drosophila melanogaster	18-28
7594817-2	1995	A-7 was found to contain a mutant p53 gene in which the arginine codon at position 175 was substituted by a histidine codon.	Histidine	108-117	tumor protein p53	Homo sapiens	34-37
7584623-6	1995	HPLC analysis on a C18 reverse-phase column showed that the purified activity displayed a very narrow substrate specificity cleaving only Thyrotropin Releasing Hormone (TRH) or the very closely related acid-TRH, LHRH (1-3) and the TRH-analogue (methyl-His)-TRH and had a Km of 100 microM for the fluorimetric substrate Glp-His-Pro-methyl-coumarin.	Histidine	252-255	thyrotropin releasing hormone	Bos taurus	138-167
7584623-6	1995	HPLC analysis on a C18 reverse-phase column showed that the purified activity displayed a very narrow substrate specificity cleaving only Thyrotropin Releasing Hormone (TRH) or the very closely related acid-TRH, LHRH (1-3) and the TRH-analogue (methyl-His)-TRH and had a Km of 100 microM for the fluorimetric substrate Glp-His-Pro-methyl-coumarin.	Histidine	323-326	thyrotropin releasing hormone	Bos taurus	138-167
7653521-1	1995	The histidine-reactive reagent, diethyl pyrocarbonate (DEPC) inhibits the human amiloride-sensitive Na+/H+ exchanger (NHE1) in stably transfected fibroblasts.	Histidine	4-13	solute carrier family 9 member A1	Homo sapiens	118-122
7627952-4	1995	Here we show that mAb PAb421 when microinjected into human SW480 colorectal carcinoma cells restores the transcription activation function to the resident mutant p53 (arg to his 273, pro to ser 309).	Histidine	174-177	tumor protein p53	Homo sapiens	162-165
7653521-2	1995	NHE1 was protected by cimetidine and amiloride from DEPC, and DEPC inhibition was reversed with hydroxylamine, suggesting a role for critical histidine groups in NHE activity.	Histidine	142-151	solute carrier family 9 member A1	Homo sapiens	0-4
7653521-6	1995	We also examined the DEPC effect on the transport activity of the triple histidine mutant (H35,120,349G) and found that NHE1 activity was still inhibited by DEPC with reversal by hydroxylamine and protected by amiloride and cimetidine.	Histidine	73-82	solute carrier family 9 member A1	Homo sapiens	120-124
7479707-0	1995	Phe-46(CD4) orients the distal histidine for hydrogen bonding to bound ligands in sperm whale myoglobin.	Histidine	31-40	T-cell surface glycoprotein CD4	Physeter catodon	7-10
8530187-5	1995	MyTI is a zinc-dependent, DNA-binding protein of the Cys2-His-Cys class.	Histidine	58-61	myelin transcription factor 1	Homo sapiens	0-4
8591044-7	1995	In the structures with inhibitor bound, the catalytic lysine (Lys13 in loop-1) and the catalytic histidine (His95 in loop-4) adopt conformations similar to those observed in wild-type TIM, but very different from the monoTIM structure.	Histidine	97-106	triosephosphate isomerase 1	Homo sapiens	184-187
7543025-4	1995	We now establish that phosphorylation following platelet activation with thrombin or collagen generates phosphohistidine at histidines on the cytoplasmic tail of P-selectin.	Histidine	124-134	coagulation factor II, thrombin	Homo sapiens	73-81
7619798-5	1995	Stabilization of the developing negative charge on the phosphonates in the soman-inhibited PSCS adducts of serine hydrolases is by electrophilic residues in the oxyanion hole (AChE) and the protonated catalytic His.	Histidine	211-214	acetylcholinesterase (Cartwright blood group)	Homo sapiens	176-180
7628486-4	1995	The essential zinc-binding histidine residues and glutamate residue, which delineate the zinc-binding domain required for both enzyme activities of LTA4 hydrolase, are divided between exons 10 and 11.	Histidine	27-36	leukotriene A4 hydrolase	Homo sapiens	148-162
7599138-0	1995	Proton transfer by histidine 67 in site-directed mutants of human carbonic anhydrase III.	Histidine	19-28	carbonic anhydrase 3	Homo sapiens	66-88
7599138-1	1995	The ability of a histidine residue at position 67 in human carbonic anhydrase III to transfer protons in the catalytic pathway for the hydration of CO2 was investigated for a series of site-specific mutants.	Histidine	17-26	carbonic anhydrase 3	Homo sapiens	59-81
7599138-7	1995	We previously showed that proton transfer from histidine 64 in carbonic anhydrase III could be described by Marcus rate theory [Silverman, D. N., Tu, C. K., Chen, X., Tanhauser, S. M., Kresge, A. J., &amp; Laipis, P. J.	Histidine	47-56	carbonic anhydrase 3	Homo sapiens	63-85
7637580-2	1995	The coding nucleotide sequence of its cDNA insert displayed high homology to rat and human selenoprotein P cDNA but contained 12 rather than 10 TGAs (12 rather than 10 selenocysteines in deduced amino acids), a tandem repeat of one CACTCC (His-Ser) and seven CATCCCs (His-Pro), and a 3" untranslated region approximately 890 bases shorter than that of rat liver selenoprotein P.	Histidine	240-243	selenoprotein P	Homo sapiens	91-106
7775460-14	1995	A molecular model based on the structure of rhodopsin, in which the 5"-NH in NECA is hydrogen bonded to Ser-277 and His-278, was developed in order to visualize the environment of the ligand binding site.	Histidine	116-119	rhodopsin	Homo sapiens	44-53
7539426-3	1995	The VWF-GPIb interaction was investigated by clustered charged-to-alanine scanning mutagenesis of VWF domain A1 between His-473 and Gly-716.	Histidine	120-123	von Willebrand factor	Homo sapiens	4-7
7539426-3	1995	The VWF-GPIb interaction was investigated by clustered charged-to-alanine scanning mutagenesis of VWF domain A1 between His-473 and Gly-716.	Histidine	120-123	von Willebrand factor	Homo sapiens	98-101
8593088-10	1995	The catalase photoinactivation by tetracycline was not eliminated by L-histidine or comparatively high concentrations of mannitol but was entirely eliminated by ethanol used in relatively low concentrations.	Histidine	69-80	catalase	Homo sapiens	4-12
7664124-2	1995	We present the predicted three-dimensional structure of the major human AP site-specific DNA repair endonuclease, HAP1, and show that an aspartate/histidine pair, in conjunction with a metal ion-coordinating glutamate residue, are critical for catalyzing the multiple repair activities of HAP1.	Histidine	147-156	huntingtin associated protein 1	Homo sapiens	114-118
7664124-2	1995	We present the predicted three-dimensional structure of the major human AP site-specific DNA repair endonuclease, HAP1, and show that an aspartate/histidine pair, in conjunction with a metal ion-coordinating glutamate residue, are critical for catalyzing the multiple repair activities of HAP1.	Histidine	147-156	huntingtin associated protein 1	Homo sapiens	289-293
7599173-5	1995	The pKa values of the four histidine residues in murine IL-6 has been measured; one has a value of 5.5, approx.	Histidine	27-36	interleukin 6	Mus musculus	56-60
7637580-2	1995	The coding nucleotide sequence of its cDNA insert displayed high homology to rat and human selenoprotein P cDNA but contained 12 rather than 10 TGAs (12 rather than 10 selenocysteines in deduced amino acids), a tandem repeat of one CACTCC (His-Ser) and seven CATCCCs (His-Pro), and a 3" untranslated region approximately 890 bases shorter than that of rat liver selenoprotein P.	Histidine	268-271	selenoprotein P	Homo sapiens	91-106
8577254-0	1995	Substitution of two histidine residues in YadA protein of Yersinia enterocolitica abrogates collagen binding, cell adherence and mouse virulence.	Histidine	20-29	Adhesin	Yersinia enterocolitica	42-46
8847343-1	1995	Photochemical techniques have been used to measure the kinetics of intramolecular electron transfer in Ru(bpy)2(im)(His)2(+)-modified (bpy = 2,2"-bipyridine; im = imidazole) cytochrome c and azurin.	Histidine	116-119	cytochrome c, somatic	Homo sapiens	174-186
8577254-5	1995	Substitution of His-156 and His-159 (YadA-2 mutant) resulted in abrogation of binding to ECM proteins, of cell adherence, and in reduction of mouse virulence, whereas autoagglutination, serum complement resistance and oligomer formation remained unaffected.	Histidine	16-19	Adhesin	Yersinia enterocolitica	37-41
8577254-5	1995	Substitution of His-156 and His-159 (YadA-2 mutant) resulted in abrogation of binding to ECM proteins, of cell adherence, and in reduction of mouse virulence, whereas autoagglutination, serum complement resistance and oligomer formation remained unaffected.	Histidine	28-31	Adhesin	Yersinia enterocolitica	37-41
7744875-4	1995	In good agreement with our structural model, substitutions at Asn-230, His-280, and Asp-281 selectively impaired the capability of shIL-6R alpha to associate with hgp130 both in vitro and on the cell surface, without affecting its affinity for hIL-6.	Histidine	71-74	interleukin 6	Homo sapiens	132-137
7755568-0	1995	An investigation of the role of Glu-842, Glu-844 and His-846 in the function of the cytoplasmic domain of the epidermal growth factor receptor.	Histidine	53-56	epidermal growth factor receptor	Homo sapiens	110-142
7755568-5	1995	Multiple sequence alignment showed that residues Glu-842, Glu-844 and His-846 are conserved or nearly conserved in eight members of the EGF receptor family.	Histidine	70-73	epidermal growth factor receptor	Homo sapiens	136-148
7663352-10	1995	However, it is possible to see that the specific interactions that renin makes with histidine at P2 would not be possible in the case of the other enzymes.	Histidine	84-93	renin	Homo sapiens	67-72
7547702-7	1995	The models predict that this region of the groove is markedly altered by allelic differences at A beta residue 9 beta (k = His, u = Val) which determine the position of the side-chain of Tyr30 beta, adjacent to residues 38 beta and 61 beta.	Histidine	123-126	histocompatibility 2, class II antigen A, beta 1	Mus musculus	96-102
7741742-4	1995	The most significant receptor to ligand interactions occur between D117 in TM3 of receptor with histidine in cyclic MSH-peptide, H260 in TM6 with glutamic in peptide and D121 in TM3 with arginine in peptide.	Histidine	96-105	msh homeobox 2	Homo sapiens	116-119
7536038-7	1995	(ii) Substitution of the C-flanking glycine in GKGRGL (residues 104-109 of myelin basic protein) with histidine, phenylalanine, lysine or aspartic acid completely abolished the ability of these hexapeptides to serve as substrates.	Histidine	102-111	myelin basic protein	Bos taurus	75-95
7711031-7	1995	The RYRs calmodulin binding site CaM1 encompasses the sequence Arg-His-Arg-Val(Ile)-Ser-Leu, which is phosphorylated in vitro by the catalytic subunit of the cAMP-dependent protein kinase.	Histidine	67-70	calmodulin 1	Homo sapiens	9-19
7711031-10	1995	These data indicate that the effect of calmodulin binding to RYR CaM1 may be regulated by the phosphorylation state of the Ser residue localized within the sequence Arg-His-Arg-Val(Ile)-Ser-Leu.	Histidine	169-172	calmodulin 1	Homo sapiens	39-49
7711031-10	1995	These data indicate that the effect of calmodulin binding to RYR CaM1 may be regulated by the phosphorylation state of the Ser residue localized within the sequence Arg-His-Arg-Val(Ile)-Ser-Leu.	Histidine	169-172	ryanodine receptor 1	Homo sapiens	61-64
7701349-1	1995	A single heterozygous nucleotide exchange in exon M2 of the gene encoding the parathyroid hormone-parathyroid hormone-related peptide (PTH-PTHrP) receptor was identified in a patient with Jansen-type metaphyseal chondrodysplasia, which changes a strictly conserved histidine residue at position 223 in the receptor"s first intracellular loop to arginine.	Histidine	265-274	parathyroid hormone 1 receptor	Homo sapiens	135-154
7664313-1	1995	The cardiac sarcolemmal Na+/Ca(2+)-exchanger was expressed in COS-7 cells by the vaccinia virus system as a fusion protein with a poly-His tag at its C-terminus.	Histidine	135-138	solute carrier family 8 member A1	Homo sapiens	24-44
7705936-1	1995	We introduced the mutant p53 gene (codon 273Arg-His) into human fibroblasts (SUSM-I cells) previously immortalized with 4-nitroquinoline I-oxide (4NQO) and obtained 2 clonal cell lines (SUSM-i/p53-1 and SUSM-1/p53-6) expressing the mutant p53.	Histidine	48-51	tumor protein p53	Homo sapiens	25-28
9049337-1	1995	The putative 38 kDa movement protein (P38) gene, located on the RNA2 of grapevine fanleaf nepovirus (GFLV), was cloned in Escherichia coli and expressed as a fusion protein fused to six histidines (6HisP38).	Histidine	186-196	mitogen-activated protein kinase 14	Homo sapiens	38-41
7896081-2	1995	The mutant PIS gene contained a CAA codon at position 114 instead of the CAC codon observed in the wild-type gene, resulting in alteration of the amino acid from His to Gln.	Histidine	162-165	CDP-diacylglycerol--inositol 3-phosphatidyltransferase	Homo sapiens	11-14
7741764-5	1995	The histidine modifying reagent diethyl-pyrocarbonate (DEPC) produced a concentration (30-100 microM) dependent inhibition of binding of both [125I]BOP and [125I]SAP.	Histidine	4-13	BOP	Homo sapiens	148-151
7775978-0	1995	Cu(II) binding by angiotensin II fragments: Asp-Arg-Val-Tyr-Ile-His and Arg-Val-Tyr-Ile-His.	Histidine	64-67	angiotensinogen	Homo sapiens	18-32
7775978-2	1995	Potentiometric and spectroscopic (absorption, circular dichroism and electron paramagnetic resonance) study on the coordination of two angiotensin II fragments (Asp-Arg-Val-Tyr-Ile-His and Arg-Val-Tyr-Ile-His) to Cu(II) ions has shown that competition between amino and imidazole nitrogens to anchor metal ions is a complicated process and may lead to formation of macrochelate rings.	Histidine	181-184	angiotensinogen	Homo sapiens	135-149
7775978-2	1995	Potentiometric and spectroscopic (absorption, circular dichroism and electron paramagnetic resonance) study on the coordination of two angiotensin II fragments (Asp-Arg-Val-Tyr-Ile-His and Arg-Val-Tyr-Ile-His) to Cu(II) ions has shown that competition between amino and imidazole nitrogens to anchor metal ions is a complicated process and may lead to formation of macrochelate rings.	Histidine	205-208	angiotensinogen	Homo sapiens	135-149
7873545-1	1995	In either sperm whale or horse heart myoglobin, binding of NO and lowering of solution pH work together to weaken, and ultimately break, the bond between iron and the proximal histidine.	Histidine	176-185	myoglobin	Equus caballus	37-46
7696519-5	1995	In addition, from the proximal histidine resonances, we have observed a preference for the binding of oxygen to the alpha-chain (up to about 10%) of hemoglobin over the beta-chain in both the presence and absence of 2,3-diphosphoglycerate.	Histidine	31-40	Fc gamma receptor and transporter	Homo sapiens	116-127
7734029-3	1995	His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 (GHRP-6) is a synthetic compound that releases GH in a dose related and specific manner in several species, including man.	Histidine	0-3	growth hormone 1	Homo sapiens	33-35
7883854-1	1995	GH-releasing peptide (GHRP-6; His-D Trp-Ala-Trp-D Phe-Lys-NH2) is a synthetic compound that releases GH in a specific and dose-related manner through mechanisms and a point of action that are mostly unknown but different from those of GHRH.	Histidine	30-33	growth hormone releasing hormone	Homo sapiens	235-239
7873552-2	1995	In a previous report Dictyostelium actin filaments with residues D24/D25 or E99/E100 replaced with histidines showed complete or partial loss of filament sliding in the in vitro motility assay [Johara, M., et al.	Histidine	99-109	actin	Saccharomyces cerevisiae S288C	35-40
7852330-2	1995	In the present investigation, we targeted Trp and His residues in human serum vitamin D-binding protein (hDBP) by modifying them with specific chemical modifiers.	Histidine	50-53	D-box binding PAR bZIP transcription factor	Homo sapiens	105-109
7706948-3	1995	Sequencing of the apoE gene from this subject (JB) revealed that the subject was heterozygous for a G to A substitution in codon 136, resulting in the substitution of histidine for arginine; therefore, we have designated this isoform apoE3" (Arg136--&gt;His).	Histidine	167-176	apolipoprotein E	Homo sapiens	18-22
7851414-8	1995	In marsupials, as in birds and reptiles, a hydrophobic tripeptide beginning with valine and ending with histidine was found in transthyretin at a position which has been identified in eutherians as the border between exon 1 and intron 1.	Histidine	104-113	transthyretin	Monodelphis domestica	127-140
7852505-8	1995	The slightly lower pI of the FDH-specific bands is consistent with the His for Arg substitution predicted by a G to A base transition recently reported in codon 218 of the gene for the variant albumin (Alb-FDH).	Histidine	71-74	albumin	Homo sapiens	202-205
7706948-3	1995	Sequencing of the apoE gene from this subject (JB) revealed that the subject was heterozygous for a G to A substitution in codon 136, resulting in the substitution of histidine for arginine; therefore, we have designated this isoform apoE3" (Arg136--&gt;His).	Histidine	254-257	apolipoprotein E	Homo sapiens	18-22
7983020-0	1994	Fatty acyl transfer by human N-myristyl transferase is dependent upon conserved cysteine and histidine residues.	Histidine	93-102	N-myristoyltransferase 1	Homo sapiens	29-51
7969498-4	1994	FcRn binds to Fc at the interface between the Fc CH2 and CH3 domains, which contains several histidine residues that could account for the sharply pH-dependent FcRn/IgG interaction.	Histidine	93-102	Fc gamma receptor and transporter	Rattus norvegicus	0-4
7988676-4	1994	The mutation of Tyr605 of mercuric reductase to a His residue produced a 24-fold decrease in kcat and a 15-fold decrease in Km.	Histidine	50-53	mercuric reductase	Escherichia coli	26-44
7808408-3	1994	We have found that the Om(2D) gene encodes a novel protein containing histidine/proline repeats, and is ubiquitously expressed during embryogenesis.	Histidine	70-79	protein Teyrha-meyrha	Drosophila ananassae	23-28
7961923-1	1994	Angiotensin I-converting enzyme (ACE) contains two zinc-dependent catalytic domains (N and C domains) each bearing the motif HEXXH where the two histidines form two of the three amino acid zinc ligands.	Histidine	145-155	angiotensin I converting enzyme	Homo sapiens	0-31
7961923-1	1994	Angiotensin I-converting enzyme (ACE) contains two zinc-dependent catalytic domains (N and C domains) each bearing the motif HEXXH where the two histidines form two of the three amino acid zinc ligands.	Histidine	145-155	angiotensin I converting enzyme	Homo sapiens	33-36
7524680-1	1994	Histidine residues in immunophilins, particularly His-126 of cyclophilin (CyP) and His-87 of the FK506 binding protein (FKBP), have been suggested to play important roles in ligand binding and peptidyl prolyl cis-trans isomerase (PPiase) catalysis.	Histidine	0-9	FKBP prolyl isomerase 5	Homo sapiens	193-228
7524680-1	1994	Histidine residues in immunophilins, particularly His-126 of cyclophilin (CyP) and His-87 of the FK506 binding protein (FKBP), have been suggested to play important roles in ligand binding and peptidyl prolyl cis-trans isomerase (PPiase) catalysis.	Histidine	0-9	FKBP prolyl isomerase 5	Homo sapiens	230-236
7524680-1	1994	Histidine residues in immunophilins, particularly His-126 of cyclophilin (CyP) and His-87 of the FK506 binding protein (FKBP), have been suggested to play important roles in ligand binding and peptidyl prolyl cis-trans isomerase (PPiase) catalysis.	Histidine	0-3	FKBP prolyl isomerase 5	Homo sapiens	193-228
7983020-7	1994	We propose a model for the Nmt reaction mechanism in which Cys-169 serves as the fatty acid attachment site for a covalent myristyl enzyme intermediate, while His-171 acts as a general acid/base and His-293 as a specific acid/base during acyl-enzyme intermediate formation.	Histidine	159-162	N-myristoyltransferase 1	Homo sapiens	27-30
7983020-7	1994	We propose a model for the Nmt reaction mechanism in which Cys-169 serves as the fatty acid attachment site for a covalent myristyl enzyme intermediate, while His-171 acts as a general acid/base and His-293 as a specific acid/base during acyl-enzyme intermediate formation.	Histidine	199-202	N-myristoyltransferase 1	Homo sapiens	27-30
7756988-6	1994	The general acid His 119 has 2 conformations (A and B) in the native structure and is found in, respectively, the A and the B conformation in the d(CpA) and the 3"-CMP complex.	Histidine	17-20	carboxypeptidase A1	Homo sapiens	148-151
7756988-8	1994	The structure of the d(CpA) complex permits a detailed analysis of the downstream binding site, which includes His 119 and Asn 71.	Histidine	111-114	carboxypeptidase A1	Homo sapiens	23-26
7524680-1	1994	Histidine residues in immunophilins, particularly His-126 of cyclophilin (CyP) and His-87 of the FK506 binding protein (FKBP), have been suggested to play important roles in ligand binding and peptidyl prolyl cis-trans isomerase (PPiase) catalysis.	Histidine	0-3	FKBP prolyl isomerase 5	Homo sapiens	230-236
7969498-4	1994	FcRn binds to Fc at the interface between the Fc CH2 and CH3 domains, which contains several histidine residues that could account for the sharply pH-dependent FcRn/IgG interaction.	Histidine	93-102	Fc gamma receptor and transporter	Rattus norvegicus	160-164
7929150-6	1994	Mouse CA V has a tyrosine at position 64, where the highly active isozyme II has histidine serving as a proton shuttle in the catalytic pathway.	Histidine	81-90	carbonic anhydrase 5a, mitochondrial	Mus musculus	6-10
7524680-1	1994	Histidine residues in immunophilins, particularly His-126 of cyclophilin (CyP) and His-87 of the FK506 binding protein (FKBP), have been suggested to play important roles in ligand binding and peptidyl prolyl cis-trans isomerase (PPiase) catalysis.	Histidine	50-53	FKBP prolyl isomerase 5	Homo sapiens	193-228
7524680-1	1994	Histidine residues in immunophilins, particularly His-126 of cyclophilin (CyP) and His-87 of the FK506 binding protein (FKBP), have been suggested to play important roles in ligand binding and peptidyl prolyl cis-trans isomerase (PPiase) catalysis.	Histidine	50-53	FKBP prolyl isomerase 5	Homo sapiens	230-236
7524680-8	1994	The pKa values of these two histidine residues in the free proteins are higher than the pKa"s obtained for the peptidyl prolyl cis-trans isomerase (PPiase) activity of these enzymes, indicating that the acid/base characters of His-87 of FKBP and His-126 of CyP are not essential in the PPiase catalysis.	Histidine	227-230	FKBP prolyl isomerase 5	Homo sapiens	111-146
7524680-8	1994	The pKa values of these two histidine residues in the free proteins are higher than the pKa"s obtained for the peptidyl prolyl cis-trans isomerase (PPiase) activity of these enzymes, indicating that the acid/base characters of His-87 of FKBP and His-126 of CyP are not essential in the PPiase catalysis.	Histidine	227-230	FKBP prolyl isomerase 5	Homo sapiens	148-154
7524680-8	1994	The pKa values of these two histidine residues in the free proteins are higher than the pKa"s obtained for the peptidyl prolyl cis-trans isomerase (PPiase) activity of these enzymes, indicating that the acid/base characters of His-87 of FKBP and His-126 of CyP are not essential in the PPiase catalysis.	Histidine	227-230	FKBP prolyl isomerase 5	Homo sapiens	286-292
7524680-8	1994	The pKa values of these two histidine residues in the free proteins are higher than the pKa"s obtained for the peptidyl prolyl cis-trans isomerase (PPiase) activity of these enzymes, indicating that the acid/base characters of His-87 of FKBP and His-126 of CyP are not essential in the PPiase catalysis.	Histidine	246-249	FKBP prolyl isomerase 5	Homo sapiens	111-146
7524680-8	1994	The pKa values of these two histidine residues in the free proteins are higher than the pKa"s obtained for the peptidyl prolyl cis-trans isomerase (PPiase) activity of these enzymes, indicating that the acid/base characters of His-87 of FKBP and His-126 of CyP are not essential in the PPiase catalysis.	Histidine	246-249	FKBP prolyl isomerase 5	Homo sapiens	148-154
7929350-5	1994	We have examined by site-specific mutagenesis of a recombinant PLA2 that is identical to an enzyme in human synovial fluid (containing His-6, Arg-7, Lys-10, and Lys-15 and a global net charge of +15) the role of basic residues in this region in PLA2 action against PLA-deficient (pldA-) E. coli.	Histidine	135-138	phospholipase A2 group IB	Homo sapiens	63-67
7947682-4	1994	While evolutionarily divergent, iron binding by all described transferrin lobes is accomplished by a remarkably similar repertoire of residues, including two Tyr, one His, and one Asp, as well as a synergestic bicarbonate anion.	Histidine	167-170	transferrin	Homo sapiens	62-73
7828354-3	1994	His-D-TRP-ALA-TRP-D-Phe-Lys-NH2 (GHRP-6) is a synthetic hexapeptide which releases GH by a direct pituitary effect through receptors other than GHRH receptors.	Histidine	0-3	growth hormone releasing hormone	Homo sapiens	144-148
7874737-2	1994	Based upon its deduced amino-acid sequence, the product of the P. pastoris HIS4 gene has the same structural organization as the Saccharomyces cerevisiae His4 protein and appears to encode a trifunctional enzyme catalyzing the second (phosphoribosyl-ATP pyrophosphohydrolase), third (phosphoribosyl-AMP cyclohydrolase), and tenth (histidinol dehydrogenase) steps in histidine biosynthesis.	Histidine	366-375	trifunctional histidinol dehydrogenase/phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase	Saccharomyces cerevisiae S288C	75-79
24226385-2	1994	The electrospray ionization mass spectra of histidine-containing human angiotensin II (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe) and angiotensin I (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu) in the presence of zinc show abundant multiply charged ions for the zinc-attached peptide [M + aZn(2+) +(c - 2a)H(+)](c+), where a = 1, 2 and c is charge.	Histidine	44-53	angiotensinogen	Homo sapiens	71-85
24226385-2	1994	The electrospray ionization mass spectra of histidine-containing human angiotensin II (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe) and angiotensin I (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu) in the presence of zinc show abundant multiply charged ions for the zinc-attached peptide [M + aZn(2+) +(c - 2a)H(+)](c+), where a = 1, 2 and c is charge.	Histidine	44-53	angiotensinogen	Homo sapiens	71-84
24226385-2	1994	The electrospray ionization mass spectra of histidine-containing human angiotensin II (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe) and angiotensin I (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu) in the presence of zinc show abundant multiply charged ions for the zinc-attached peptide [M + aZn(2+) +(c - 2a)H(+)](c+), where a = 1, 2 and c is charge.	Histidine	107-110	angiotensinogen	Homo sapiens	71-85
24226385-2	1994	The electrospray ionization mass spectra of histidine-containing human angiotensin II (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe) and angiotensin I (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu) in the presence of zinc show abundant multiply charged ions for the zinc-attached peptide [M + aZn(2+) +(c - 2a)H(+)](c+), where a = 1, 2 and c is charge.	Histidine	107-110	angiotensinogen	Homo sapiens	71-84
7999999-3	1994	The 615 bp sequence in P. contorta contained perfectly matched motifs for the serine and histidine active sites of the ClpP protease in E. coli.	Histidine	89-98	clpP	Pinus contorta	119-123
7918471-3	1994	We here present direct evidence that HNE derivatization of LDL forms Michael addition-type adducts of HNE with histidine and lysine residues of apolipoprotein B-100 (apoB) and also demonstrate the utility of an antibody specific to the HNE adducts generated in the LDL treated with HNE or oxidatively modified by Cu2+ or cultured endothelial cells.	Histidine	111-120	apolipoprotein B	Homo sapiens	144-164
7918471-3	1994	We here present direct evidence that HNE derivatization of LDL forms Michael addition-type adducts of HNE with histidine and lysine residues of apolipoprotein B-100 (apoB) and also demonstrate the utility of an antibody specific to the HNE adducts generated in the LDL treated with HNE or oxidatively modified by Cu2+ or cultured endothelial cells.	Histidine	111-120	apolipoprotein B	Homo sapiens	166-170
8093013-1	1994	Chemical modification of aminopeptidase from pronase has revealed two important histidines in enzyme catalysis.	Histidine	80-90	carboxypeptidase Q	Homo sapiens	25-39
7937752-3	1994	Using conformational energy analysis based on ECEPP (Empirical Conformational Energy for Peptides Program), we have determined the low-energy three-dimensional structures for this dodecapeptide sequence for the human wild-type p53 protein and three environmentally induced, cancer-related mutant p53 proteins with His-151, Ser-152, and Val-154, respectively.	Histidine	314-317	tumor protein p53	Homo sapiens	227-230
7918357-3	1994	Comparison of the erythrocytic cytochrome with the trypsin-solubilized bovine liver cytochrome b5 by potentiometric titration indicates that the principal electrostatic difference between the two proteins results from two additional His residues present in the human erythrocytic protein.	Histidine	233-236	cytochrome b5 type A	Bos taurus	84-97
7847818-5	1994	Wild-type p53 as well as one mutant p53 [(mutation of arginine to histidine at codon 273 (His 273)], had strong transactivating activity, but all other mutant p53s were inactive in transcriptional activation, including the double mutant Tyr141/His273 suggesting that the Tyr141 mutation was dominant over the His273 mutation in the same protein.	Histidine	90-93	tumor protein p53	Homo sapiens	10-13
7847818-5	1994	Wild-type p53 as well as one mutant p53 [(mutation of arginine to histidine at codon 273 (His 273)], had strong transactivating activity, but all other mutant p53s were inactive in transcriptional activation, including the double mutant Tyr141/His273 suggesting that the Tyr141 mutation was dominant over the His273 mutation in the same protein.	Histidine	90-93	tumor protein p53	Homo sapiens	36-39
7847818-5	1994	Wild-type p53 as well as one mutant p53 [(mutation of arginine to histidine at codon 273 (His 273)], had strong transactivating activity, but all other mutant p53s were inactive in transcriptional activation, including the double mutant Tyr141/His273 suggesting that the Tyr141 mutation was dominant over the His273 mutation in the same protein.	Histidine	90-93	tumor protein p53	Homo sapiens	36-39
7831282-4	1994	Creation of an equivalent His-His structure in the homologous human GST M1-1 by protein engineering afforded a mutant enzyme that displays affinity for Ni(II)-IDA-agarose, in contrast to the wild-type GST M1-1.	Histidine	26-29	glutathione S-transferase mu 1	Homo sapiens	68-76
7820939-2	1994	In this study, we have evaluated the physiological effect of three apo A-IV polymorphisms (Gln360- &gt; His, Thr347- &gt; Ser and XbaI within the second intron of the apo A-IV gene), in a French population, on seven quantitative traits: total cholesterol and triglycerides, cholesterol of HDL, apo A-IV, apo B, apo A-I and glucose.	Histidine	104-107	apolipoprotein A4	Homo sapiens	67-75
7831282-4	1994	Creation of an equivalent His-His structure in the homologous human GST M1-1 by protein engineering afforded a mutant enzyme that displays affinity for Ni(II)-IDA-agarose, in contrast to the wild-type GST M1-1.	Histidine	30-33	glutathione S-transferase mu 1	Homo sapiens	68-76
7951671-8	1994	A recent study of the level of pituitary resistance in a large kindred with GRTH (ARG-320-HIS mutation) indicated a contributory gene in the regulation of thyroid hormone action.	Histidine	90-93	thyroid hormone receptor beta	Homo sapiens	76-80
8051115-2	1994	The role of the proximal histidine ligand in peroxidase function was studied by replacing the His side chain in cytochrome c peroxidase with Gln, Glu, or Cys.	Histidine	94-97	cytochrome c, somatic	Homo sapiens	112-124
7950378-2	1994	An expression vector was constructed that contains a string of 10 histidine residues ligated, in frame, to the amino terminal end of the Xenopus nucleoplasmin gene.	Histidine	66-75	nucleophosmin/nucleoplasmin 2 S homeolog	Xenopus laevis	145-158
8055951-0	1994	Site-specific oxidation of histidine residues in glycated insulin mediated by Cu2+.	Histidine	27-36	insulin	Homo sapiens	58-65
8055951-1	1994	The site-specific oxidation of histidine residues in glycated insulin mediated by copper ions and the relationship between the oxidation sites and the steric conformation of insulin are discussed in this study.	Histidine	31-40	insulin	Homo sapiens	62-69
8055951-1	1994	The site-specific oxidation of histidine residues in glycated insulin mediated by copper ions and the relationship between the oxidation sites and the steric conformation of insulin are discussed in this study.	Histidine	31-40	insulin	Homo sapiens	174-181
8045963-1	1994	His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 (called GHRP-6) is a synthetic compound that releases GH in a dose-related, specific, and nonspecies-specific manner, through mechanisms different from those of GHRH.	Histidine	0-3	growth hormone 1	Homo sapiens	40-42
8045963-1	1994	His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 (called GHRP-6) is a synthetic compound that releases GH in a dose-related, specific, and nonspecies-specific manner, through mechanisms different from those of GHRH.	Histidine	0-3	growth hormone releasing hormone	Homo sapiens	193-197
8041764-5	1994	Replacement of His-150, the residue in hETB that is analogous in sequence to Tyr-129 of hETA, by either tyrosine or alanine does not affect the affinity of peptide ligands.	Histidine	15-18	endothelin receptor type B	Homo sapiens	39-43
7913472-0	1994	Histidine 326 is critical for the function of GLT-1, a (Na+ + K+)-coupled glutamate transporter from rat brain.	Histidine	0-9	solute carrier family 1 member 2	Rattus norvegicus	46-51
8018667-0	1994	Sex-specific effects of the glutamine/histidine polymorphism in apo A-IV on HDL metabolism.	Histidine	38-47	apolipoprotein A4	Homo sapiens	64-72
8037771-4	1994	These results confirm that His261(95) is the distal histidine essential for the catalytic activity of the enzyme while Asp260(94), Met409(243) and Glu408(242) are necessary for maintaining the correct conformation of the active site and all four residues that interact closely with the periphery of the heme contribute to the unique spectral properties of the heme in MPO.	Histidine	52-61	myeloperoxidase	Homo sapiens	368-371
7518430-0	1994	Functional alterations in adult and fetal hemoglobin Sassari Asp-alpha 126(H9)--&gt;His.	Histidine	84-87	aspartoacylase	Homo sapiens	61-70
8025104-0	1994	High-resolution structure of an engineered biologically potent insulin monomer, B16 Tyr--&gt;His, as determined by nuclear magnetic resonance spectroscopy.	Histidine	93-96	insulin	Homo sapiens	63-70
8018667-1	1994	In Caucasians, a histidine for glutamine substitution (Gln--&gt;His) at residue 360 in apolipoprotein (apo) A-IV leads to an electrophoretically detectable polymorphism whose contribution to lipid metabolism regulation is controversial.	Histidine	17-26	apolipoprotein A4	Homo sapiens	87-112
8037675-3	1994	Ni2+ binds to a site in the N-terminal region of the protein which is partially blocked by the presence of a propeptide as in proalbumin (proAlb) Varese (Arg-2--&gt;His), proAlb Christchurch (Arg-1--&gt;Gln) and proAlb Blenheim (Asp1--&gt;Val) and by the presence of only an extra Arg residue (Arg-1) as in Arg-Alb and albumin (Alb) Redhill.	Histidine	165-168	albumin	Homo sapiens	141-144
8018667-1	1994	In Caucasians, a histidine for glutamine substitution (Gln--&gt;His) at residue 360 in apolipoprotein (apo) A-IV leads to an electrophoretically detectable polymorphism whose contribution to lipid metabolism regulation is controversial.	Histidine	64-67	apolipoprotein A4	Homo sapiens	87-112
8018667-3	1994	The frequency of the rarer apo A-IV (360:His) allele was .069.	Histidine	41-44	apolipoprotein A4	Homo sapiens	27-35
8002937-2	1994	Two molecular forms of insulin which differ by a single amino acid substitution, His or Asp at position 15 of the A chain, were isolated from the pancreas of the paddlefish.	Histidine	81-84	insulin	Homo sapiens	23-30
8016074-6	1994	It is known that His-504 in soybean lipoxygenase 1, which corresponds to His-532 in lipoxygenase 2, is one of the iron-binding ligands essential for lipoxygenase activity.	Histidine	17-20	seed linoleate 13S-lipoxygenase-1	Glycine max	36-50
8016074-6	1994	It is known that His-504 in soybean lipoxygenase 1, which corresponds to His-532 in lipoxygenase 2, is one of the iron-binding ligands essential for lipoxygenase activity.	Histidine	73-76	seed linoleate 13S-lipoxygenase-1	Glycine max	36-50
8074930-9	1994	Multivalent SMAA complexes were made that contained His-p17-Pk, His-p27-Pk, His-rt-Pk, His-vpx-Pk, and His-vpr-Pk.	Histidine	52-55	family with sequence similarity 72, member A	Mus musculus	56-59
8074930-12	1994	Mice were also immunized with His-p17-Pk or His-p17-Pk-antibody complexes in the presence or absence of alum.	Histidine	30-33	family with sequence similarity 72, member A	Mus musculus	34-37
8074930-12	1994	Mice were also immunized with His-p17-Pk or His-p17-Pk-antibody complexes in the presence or absence of alum.	Histidine	44-47	family with sequence similarity 72, member A	Mus musculus	48-51
7889418-4	1994	We find that alteration of a histidine pair within the alpha 3 domain of FcRn and of a nearby loop (the FcRn counterpart of the class I CD8-binding loop) affects the affinity for IgG.	Histidine	29-38	Fc gamma receptor and transporter	Homo sapiens	73-77
7889418-4	1994	We find that alteration of a histidine pair within the alpha 3 domain of FcRn and of a nearby loop (the FcRn counterpart of the class I CD8-binding loop) affects the affinity for IgG.	Histidine	29-38	Fc gamma receptor and transporter	Homo sapiens	104-108
7889418-7	1994	Three histidines present at the CH2-CH3 domain interface of Fc could be partially responsible for the pH-dependent interaction between FcRn and IgG.	Histidine	6-16	Fc gamma receptor and transporter	Homo sapiens	135-139
8004673-4	1994	We have characterized patient-specific DHP receptor mutations in 11 probands of 33 independent hypoKPP kindreds that occur at one of two adjacent nucleotides within the same codon and predict substitution of a highly conserved arginine in the S4 segment of domain 4 with either histidine or glycine.	Histidine	278-287	calcium voltage-gated channel subunit alpha1 S	Homo sapiens	39-51
8180397-2	1994	Wild-type acetylcholinesterase, YT1, has histidine at codon 322, whereas the genetic variant of acetylcholinesterase, YT2, has asparagine.	Histidine	41-50	acetylcholinesterase (Cartwright blood group)	Homo sapiens	10-30
8187275-0	1994	Role of histidine 95 on pH gating of the cardiac gap junction protein connexin43.	Histidine	8-17	gap junction protein, alpha 1	Rattus norvegicus	70-80
8187275-1	1994	We have studied the role of histidine 95 (H95) on the pH gating of the cardiac gap junction protein connexin43 (Cx43).	Histidine	28-37	gap junction protein, alpha 1	Rattus norvegicus	100-110
8187275-1	1994	We have studied the role of histidine 95 (H95) on the pH gating of the cardiac gap junction protein connexin43 (Cx43).	Histidine	28-37	gap junction protein, alpha 1	Rattus norvegicus	112-116
8187275-9	1994	Our data indicate that a properly placed histidine residue is an important structural element for functional expression as well as for pH regulation of Cx43.	Histidine	41-50	gap junction protein, alpha 1	Rattus norvegicus	152-156
8194601-2	1994	The hyperfine couplings of the remote nitrogens of histidine ligands are determined for the first time by an X-band ESEEM spectroscopy study of 15N-substituted superoxide dismutase (SOD).	Histidine	51-60	superoxide dismutase 1	Homo sapiens	160-180
8194601-2	1994	The hyperfine couplings of the remote nitrogens of histidine ligands are determined for the first time by an X-band ESEEM spectroscopy study of 15N-substituted superoxide dismutase (SOD).	Histidine	51-60	superoxide dismutase 1	Homo sapiens	182-185
8186254-1	1994	The distal histidine (E7) of horse heart myoglobin (Mb) has been replaced by tyrosine using site-specific mutagenesis.	Histidine	11-20	myoglobin	Equus caballus	41-50
8187062-2	1994	The cells carry only a mutated form of the p53 gene, the G--&gt;A mutation at codon 273 which results in an arginine to histidine substitution (mp53).	Histidine	120-129	tumor protein p53	Homo sapiens	43-46
8205256-4	1994	Sequence analysis of the coding exons of the androgen receptor gene from the patients revealed a single nucleotide substitution at position 2881 in exon G, resulting in the conversion of arginine (CGT) to histidine (CAT) at amino acid position 840 in the hormone-binding domain of the androgen receptor.	Histidine	205-214	androgen receptor	Homo sapiens	45-62
8205256-4	1994	Sequence analysis of the coding exons of the androgen receptor gene from the patients revealed a single nucleotide substitution at position 2881 in exon G, resulting in the conversion of arginine (CGT) to histidine (CAT) at amino acid position 840 in the hormone-binding domain of the androgen receptor.	Histidine	205-214	catalase	Homo sapiens	216-219
8205256-4	1994	Sequence analysis of the coding exons of the androgen receptor gene from the patients revealed a single nucleotide substitution at position 2881 in exon G, resulting in the conversion of arginine (CGT) to histidine (CAT) at amino acid position 840 in the hormone-binding domain of the androgen receptor.	Histidine	205-214	androgen receptor	Homo sapiens	285-302
7923904-6	1994	Genotyping for the I/D polymorphism was performed by polymerase chain reaction and plasma DCP1 activity was measured by rate of hydrolysis of both [3H]-Hip-Gly-Gly and Hip-His-Leu.	Histidine	172-175	angiotensin I converting enzyme	Homo sapiens	90-94
8161798-3	1994	1436 from the translational initiation site of the R-type PK (R-PK) mRNA, and it caused a single amino acid substitution from Arg to His at the 479th amino acid residue of the R-PK.	Histidine	133-136	pyruvate kinase L/R	Homo sapiens	51-60
8161798-3	1994	1436 from the translational initiation site of the R-type PK (R-PK) mRNA, and it caused a single amino acid substitution from Arg to His at the 479th amino acid residue of the R-PK.	Histidine	133-136	pyruvate kinase L/R	Homo sapiens	62-66
8161798-3	1994	1436 from the translational initiation site of the R-type PK (R-PK) mRNA, and it caused a single amino acid substitution from Arg to His at the 479th amino acid residue of the R-PK.	Histidine	133-136	pyruvate kinase L/R	Homo sapiens	176-180
8165131-2	1994	A histidine tag and a factor Xa recognition site-carrying mouse TBP was expressed in E. coli, highly purified, and its fundamental functions as a TBP were demonstrated.	Histidine	2-11	TATA box binding protein	Mus musculus	146-149
8054455-7	1994	This mutation results in the amino acid substitution Arg--&gt;His at position 16 of the A alpha chain, the site of thrombin cleavage.	Histidine	62-65	coagulation factor II, thrombin	Homo sapiens	115-123
8175966-1	1994	The synthetic hexapeptide GH-releasing peptide (GHRP; His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) specifically stimulates GH secretion in humans in vivo and in animals in vitro and in vivo via a still unknown receptor and mechanism.	Histidine	54-57	growth hormone 1	Homo sapiens	26-28
7913773-5	1994	Further analysis of the father and members of other arms of the kindred revealed a different mutation (C insertion: CAT-->CCAT), resulting in a frameshift beginning at amino acid #107 (His-->Pro) and truncation of the protein at codon #119 of the mature protein.	Histidine	185-188	catalase	Homo sapiens	116-119
8157637-5	1994	Site-directed mutagenesis was employed to generate three mutant LIM2 proteins with conversions of the second conserved cysteine to histidine (C2H), the fifth conserved cysteine to histidine (C5H), and the last conserved cysteine to aspartate (C8D).	Histidine	131-140	lens intrinsic membrane protein 2	Homo sapiens	64-68
8157637-5	1994	Site-directed mutagenesis was employed to generate three mutant LIM2 proteins with conversions of the second conserved cysteine to histidine (C2H), the fifth conserved cysteine to histidine (C5H), and the last conserved cysteine to aspartate (C8D).	Histidine	180-189	lens intrinsic membrane protein 2	Homo sapiens	64-68
7909256-1	1994	Direct sequencing showed a G-A point mutation at position 2818 of exon 7, which was responsible for an arginine-histidine substitution at position 840 of the androgen receptor.	Histidine	112-121	androgen receptor	Homo sapiens	158-175
8137809-9	1994	A metal-binding site in the substrate-binding pocket is formed by the three histidine residues 23, 48 and 50 from one 6-pyruvoyl tetrahydropterin synthase subunit.	Histidine	76-85	6-pyruvoyl-tetrahydropterin synthase	Rattus norvegicus	118-154
7510762-7	1994	The quantitation of bound peptide in the eluted complexes showed 100% occupancy of HLA-DR2 (DRB1*1501/DRB5*0101) with [6 x His-MBP(83-102)Y83] peptide with a recovery of 50-75%.	Histidine	123-126	major histocompatibility complex, class II, DR beta 1	Homo sapiens	92-96
7509807-8	1994	The compound has 230- and 10-fold reduced affinity for mutant NK-1 receptors in which histidine 265 or histidine 197, respectively, are replaced with alanine.	Histidine	86-95	tachykinin precursor 1	Homo sapiens	62-66
7907325-7	1994	While most of these hydrophobic amino acids are beta-sheet formers, GroEL interacts also with the alpha-helix formers Glu, Ala, Gln, and His.	Histidine	137-140	GroEL	Escherichia coli	68-73
7509807-8	1994	The compound has 230- and 10-fold reduced affinity for mutant NK-1 receptors in which histidine 265 or histidine 197, respectively, are replaced with alanine.	Histidine	103-112	tachykinin precursor 1	Homo sapiens	62-66
8133041-8	1994	This C-terminal acidic amino acid may interact with an arginine residue in the MHC class II alpha-chain that is exposed when beta-chain residue 57 is mutated to serine, or to the unique beta-chain residue histidine 56.	Histidine	205-214	histocompatibility 2, class II antigen E alpha	Mus musculus	79-103
8126161-2	1994	Recent investigations suggest an etiological role for embryonic somatic missense mutations that predict the substitution of a His or Cys for Arg at amino acid 201 of the Gs alpha-subunit (Gs alpha).	Histidine	126-129	GNAS complex locus	Homo sapiens	170-178
8126161-2	1994	Recent investigations suggest an etiological role for embryonic somatic missense mutations that predict the substitution of a His or Cys for Arg at amino acid 201 of the Gs alpha-subunit (Gs alpha).	Histidine	126-129	GNAS complex locus	Homo sapiens	188-196
8126161-8	1994	DNA sequence predicting a His for Arg substitution at Gs alpha amino acid 201 was found in 47% of the recombinant plasmids from DNA of affected bone and 17% of the plasmids from DNA of unaffected bone; a significant (P &lt; 0.05) difference in frequency.	Histidine	26-29	GNAS complex locus	Homo sapiens	54-62
8119983-1	1994	Cytochrome c3 (M(r) 13,000) is a tetrahemic cytochrome in which the four heme iron atoms are coordinated by 2 histidine residues at the axial positions.	Histidine	110-119	cytochrome c, somatic	Homo sapiens	0-12
8119983-3	1994	To investigate this mechanism, four single mutations were introduced in cytochrome c3 by site-directed mutagenesis, leading to the replacement of each histidine, the sixth axial ligand of the heme iron atom, by a methionine residue.	Histidine	151-160	cytochrome c, somatic	Homo sapiens	72-84
8308004-1	1994	It has been proposed that the histidine at position 21 (H21) of the diphtheria toxin A subunit (DTA) plays an important role in the ADP-ribosyltransferase (ADPRT) activity of the toxin.	Histidine	30-39	poly(ADP-ribose) polymerase 1	Homo sapiens	132-154
8119968-5	1994	Additionally, a naturally occurring mutation (histidine B10 to aspartic acid) yields a form of human insulin which accumulates 10- to over 100-fold more mature insulin when compared to the mutants lacking this change.	Histidine	46-55	insulin	Homo sapiens	101-108
8119968-5	1994	Additionally, a naturally occurring mutation (histidine B10 to aspartic acid) yields a form of human insulin which accumulates 10- to over 100-fold more mature insulin when compared to the mutants lacking this change.	Histidine	46-55	insulin	Homo sapiens	160-167
8119287-5	1994	A second His residue is also close to the Cu2+/Ni2+ binding site in bovine serum albumin and is assigned to His59 (not present in human albumin).	Histidine	9-12	albumin	Homo sapiens	75-88
8107115-1	1994	The structure of mouse submaxillary renin complexed with a decapeptide inhibitor, CH-66 (Piv-His-Pro-Phe-His-Leu-OH-Leu-Tyr-Tyr-Ser-NH2), where Piv denotes a pivaloyl blocking group, and -OH- denotes a hydroxyethylene (-(S)CHOH-CH2-) transition state isostere as a scissile bond surrogate, has been refined to an agreement factor of 0.18 at 2.0 A resolution.	Histidine	93-96	renin	Homo sapiens	36-41
8308004-1	1994	It has been proposed that the histidine at position 21 (H21) of the diphtheria toxin A subunit (DTA) plays an important role in the ADP-ribosyltransferase (ADPRT) activity of the toxin.	Histidine	30-39	poly(ADP-ribose) polymerase 1	Homo sapiens	156-161
8112732-5	1994	In four out of the five patients, heterozygous germline mutations were found: a novel point mutation in exon 8 (ZF2) at codon 377 altering the wild-type histidine to arginine, and three previously described point mutations in exon 9 (ZF3) in the codons corresponding to amino acids 394Arg and 396Asp.	Histidine	153-162	zinc finger protein 274	Homo sapiens	112-115
7656014-2	1994	The global fold consists of three helices, a five stranded beta-sheet and a methionine located in a turn near the catalytic histidines, classifying stromelysin-1 as a metzincin.	Histidine	124-134	matrix metallopeptidase 3	Homo sapiens	148-161
8245005-2	1993	Structural models of human aldose reductase complexed with NADPH have revealed the apposition of C4 of the nicotinamide ring with tyrosine 48 and histidine 110, suggesting that either of these residues could function as the proton donor in the reaction mechanism.	Histidine	146-155	aldo-keto reductase family 1 member B	Homo sapiens	27-43
7698720-0	1994	Prolactin responsiveness to peptide histidine methionine-27 in normal subjects and hyperprolactinemic patients.	Histidine	36-45	prolactin	Homo sapiens	0-9
7698720-1	1994	In order to verify whether synthetic peptide histidine methionine (PHM-27) is able to induce serum prolactin (PRL) rise in normal subjects and to investigate its effect on PRL secretion in hyperprolactinemic conditions, PHM-27 (100 micrograms i.v.	Histidine	45-54	vasoactive intestinal peptide	Homo sapiens	67-73
7698720-1	1994	In order to verify whether synthetic peptide histidine methionine (PHM-27) is able to induce serum prolactin (PRL) rise in normal subjects and to investigate its effect on PRL secretion in hyperprolactinemic conditions, PHM-27 (100 micrograms i.v.	Histidine	45-54	prolactin	Homo sapiens	99-108
7698720-1	1994	In order to verify whether synthetic peptide histidine methionine (PHM-27) is able to induce serum prolactin (PRL) rise in normal subjects and to investigate its effect on PRL secretion in hyperprolactinemic conditions, PHM-27 (100 micrograms i.v.	Histidine	45-54	prolactin	Homo sapiens	110-113
8131215-3	1994	Myeloperoxidase-dependent degradation of hyaluronic acid is inhibited by superoxide dismutase, desferrioxamine, iodide ion, bromide ion, mannitol, histidine and various antiinflammatory agents.	Histidine	147-156	myeloperoxidase	Homo sapiens	0-15
7866410-0	1994	Marked zinc activation of ester hydrolysis by a mutation, 67-His (CAT) to Arg (CGT), in the active site of human carbonic anhydrase I.	Histidine	61-64	catalase	Homo sapiens	66-69
8119733-10	1994	Substitution of his &gt; arg at position 114 blocked surface expression of both 242K and wild-type HLA-A*0201 molecules.	Histidine	16-19	major histocompatibility complex, class I, A	Homo sapiens	99-104
8248148-6	1993	Cleavage at the 2/3 site was abolished by alanine substitutions for NS2 residues His-952 or Cys-993 but was unaffected by several other substitution mutations, including those that inactivate NS3 serine proteinase function.	Histidine	81-84	NS2	Homo sapiens	68-71
8269928-3	1993	Induction of the regulatory GCN4 mechanism upon histidine starvation, using the anti-metabolite 3-amino-1,2,4-triazole, increased the levels of PDA1 mRNA by approximately 40%.	Histidine	48-57	pyruvate dehydrogenase (acetyl-transferring) subunit E1 alpha	Saccharomyces cerevisiae S288C	144-148
8136024-3	1993	The further substitution of Asp for B10 His in [B16 Phe, B26 Phe]insulin raises its activity to approximately twofold greater than natural insulin, an increase of approximately fivefold over the parent compound.	Histidine	40-43	insulin	Homo sapiens	65-72
8136024-3	1993	The further substitution of Asp for B10 His in [B16 Phe, B26 Phe]insulin raises its activity to approximately twofold greater than natural insulin, an increase of approximately fivefold over the parent compound.	Histidine	40-43	insulin	Homo sapiens	139-146
8245966-7	1993	The pH profile of heparin-induced aggregation of A beta(1-28) has a midpoint pH of approximately 6.5, suggesting that one or more histidine residues must be protonated for binding to occur.	Histidine	130-139	amyloid beta precursor protein	Homo sapiens	49-55
8245966-8	1993	Analysis of the A beta sequence reveals a consensus heparin-binding domain at residues 12-17, and this motif contains histidines at positions 13 and 14 that may be involved in the interaction with glycosaminoglycans.	Histidine	118-128	amyloid beta precursor protein	Homo sapiens	16-22
7504274-4	1993	The identified library epitopes shared the consensus sequence Pro-(Pro/Ser)-Gly-His-(Tyr/Phe)-Lys, corresponding to two continuous protein sequences of bFGF: Pro-Pro-Gly-His-Phe-Lys and Arg-Thr-Gly-Gln-Tyr-Lys at amino acids 13-18 and 120-125 of bFGF, respectively.	Histidine	80-83	fibroblast growth factor 2	Homo sapiens	152-156
8218231-5	1993	The R6 insulin hexamer is stabilized by heterotropic interactions between the hydrophobic protein pockets and the coordination sites of the His(B10)-bound metal ions.	Histidine	140-143	insulin	Homo sapiens	7-14
8106171-4	1993	Moreover, a histidine substitutes for a highly conserved proline at position 7 of the MSX2 homeodomain exclusively in affected members.	Histidine	12-21	msh homeobox 2	Homo sapiens	86-90
8218384-5	1993	Peptide mapping experiments were used to find the sites of DEPC incorporation within the primary structure of TIMP and three residues were identified (His-95, His-144 and His-164).	Histidine	159-162	TIMP metallopeptidase inhibitor 1	Homo sapiens	110-114
8218384-5	1993	Peptide mapping experiments were used to find the sites of DEPC incorporation within the primary structure of TIMP and three residues were identified (His-95, His-144 and His-164).	Histidine	159-162	TIMP metallopeptidase inhibitor 1	Homo sapiens	110-114
8218384-8	1993	The possible contribution made by His residues 95, 144 and 164 to the inhibitory activity of TIMP is discussed.	Histidine	34-37	TIMP metallopeptidase inhibitor 1	Homo sapiens	93-97
8106195-0	1993	Influence of methylation of the histidine ring of [Sar1]angiotensin II on conformation and biological activity.	Histidine	32-41	angiotensinogen	Rattus norvegicus	51-70
8240272-5	1993	In the pancreas, there were unmodified, mono- and di-phosphorylated forms of the fragment chromogranin A(248-313) with Arg and Glu at positions 293 and 301 respectively; in addition, there were small amounts of monophosphorylated peptide with an alternative primary sequence of His and Lys at 293 and 301 respectively.	Histidine	278-281	chromogranin A	Bos taurus	90-104
8287399-10	1993	ACE activity in the kidney was only increased 80 d after the induction of heart failure [17(SEM 1) v 11.2(0.5) nM His-Leu generated per min.mg-1, p &lt; 0.01], while plasma ACE activity was not increased in any heart failure group.	Histidine	114-117	angiotensin I converting enzyme	Rattus norvegicus	0-3
8400271-7	1993	We detected the in-frame deletion of the trinucleotide CAT, encoding histidine 469, two amino acid residues to the N-terminal side of the abnormal proteolytic cleavage site between residues 470 and 471.	Histidine	69-78	catalase	Homo sapiens	55-58
8223615-1	1993	Expression of a human tumour-derived p53 His 273 cDNA induced growth arrest in fission yeast Schizosaccharomyces pombe.	Histidine	41-44	tumor protein p53	Homo sapiens	37-40
8269791-7	1993	Genetic analysis revealed a point mutation affecting residue 65 of human proinsulin (Arg--&gt;His) in one allele of the insulin gene in the propositus, a defect similar to that described previously in 3 other apparently unrelated lineages.	Histidine	94-97	insulin	Homo sapiens	73-83
8269791-7	1993	Genetic analysis revealed a point mutation affecting residue 65 of human proinsulin (Arg--&gt;His) in one allele of the insulin gene in the propositus, a defect similar to that described previously in 3 other apparently unrelated lineages.	Histidine	94-97	insulin	Homo sapiens	76-83
8396932-3	1993	Partial amino acid sequence information confirms the identity of the enzyme as a peroxidase but shows significant deviation from other plant peroxidases in the distal histidine box.	Histidine	167-176	peroxidase	Glycine max	81-91
8376405-0	1993	Type IIB mutation His-505--&gt;Asp implicates a new segment in the control of von Willebrand factor binding to platelet glycoprotein Ib.	Histidine	18-21	von Willebrand factor	Homo sapiens	78-99
8376405-7	1993	Relative to wild type vWF, the mutant vWF exhibited markedly increased binding to platelets at low concentrations of ristocetin, confirming the association between the His-505--&gt;Asp substitution and the type IIB vWD phenotype.	Histidine	168-171	von Willebrand factor	Homo sapiens	38-41
8376405-8	1993	The His-505--&gt;Asp mutation lies outside the disulfide loop affected by other type IIB vWD mutations and implicates a new segment of vWF in the regulation of platelet glycoprotein Ib binding.	Histidine	4-7	von Willebrand factor	Homo sapiens	135-138
8252036-5	1993	The data suggest that the catalytic centre of aspartoacylase involves a triad of Ser, His and Glu residues.	Histidine	86-89	aspartoacylase	Homo sapiens	46-60
8370708-2	1993	In healthy humans, the synthetic peptide GH-releasing peptide (GHRP) (His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) releases GH by a putative mechanism of action that is independent of GHRH.	Histidine	70-73	growth hormone 1	Homo sapiens	41-43
8375386-2	1993	Depending on the localization of invHIS4C on the endoplasmic reticulum (ER) cytoplasmic or luminal side, the enzyme converts histidinol to histidine and allows the his4 yeast strain to grow on histidinol-supplemented medium.	Histidine	139-148	trifunctional histidinol dehydrogenase/phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase	Saccharomyces cerevisiae S288C	164-168
8370708-2	1993	In healthy humans, the synthetic peptide GH-releasing peptide (GHRP) (His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) releases GH by a putative mechanism of action that is independent of GHRH.	Histidine	70-73	growth hormone releasing hormone	Homo sapiens	172-176
8245954-1	1993	The metastable, reversible carbethoxylation of histidine in the cobalt(III) complexes (ethylene-diamine)(histidine)chlorocobalt(III) chloride, [Co(III)(en)ClHis]Cl, and (diethylenetriamine) (histidine)cobalt(III) dichloride, [Co(III)(dien)His]Cl2, following reaction with diethylpyrocarbonate, was observed using UV spectroscopy.	Histidine	47-56	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	71-74
8245954-1	1993	The metastable, reversible carbethoxylation of histidine in the cobalt(III) complexes (ethylene-diamine)(histidine)chlorocobalt(III) chloride, [Co(III)(en)ClHis]Cl, and (diethylenetriamine) (histidine)cobalt(III) dichloride, [Co(III)(dien)His]Cl2, following reaction with diethylpyrocarbonate, was observed using UV spectroscopy.	Histidine	47-56	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	128-131
8245954-1	1993	The metastable, reversible carbethoxylation of histidine in the cobalt(III) complexes (ethylene-diamine)(histidine)chlorocobalt(III) chloride, [Co(III)(en)ClHis]Cl, and (diethylenetriamine) (histidine)cobalt(III) dichloride, [Co(III)(dien)His]Cl2, following reaction with diethylpyrocarbonate, was observed using UV spectroscopy.	Histidine	105-114	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	71-74
8245954-1	1993	The metastable, reversible carbethoxylation of histidine in the cobalt(III) complexes (ethylene-diamine)(histidine)chlorocobalt(III) chloride, [Co(III)(en)ClHis]Cl, and (diethylenetriamine) (histidine)cobalt(III) dichloride, [Co(III)(dien)His]Cl2, following reaction with diethylpyrocarbonate, was observed using UV spectroscopy.	Histidine	105-114	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	128-131
8245954-1	1993	The metastable, reversible carbethoxylation of histidine in the cobalt(III) complexes (ethylene-diamine)(histidine)chlorocobalt(III) chloride, [Co(III)(en)ClHis]Cl, and (diethylenetriamine) (histidine)cobalt(III) dichloride, [Co(III)(dien)His]Cl2, following reaction with diethylpyrocarbonate, was observed using UV spectroscopy.	Histidine	47-56	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	144-151
8245954-1	1993	The metastable, reversible carbethoxylation of histidine in the cobalt(III) complexes (ethylene-diamine)(histidine)chlorocobalt(III) chloride, [Co(III)(en)ClHis]Cl, and (diethylenetriamine) (histidine)cobalt(III) dichloride, [Co(III)(dien)His]Cl2, following reaction with diethylpyrocarbonate, was observed using UV spectroscopy.	Histidine	105-114	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	144-151
8245954-1	1993	The metastable, reversible carbethoxylation of histidine in the cobalt(III) complexes (ethylene-diamine)(histidine)chlorocobalt(III) chloride, [Co(III)(en)ClHis]Cl, and (diethylenetriamine) (histidine)cobalt(III) dichloride, [Co(III)(dien)His]Cl2, following reaction with diethylpyrocarbonate, was observed using UV spectroscopy.	Histidine	105-114	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	128-131
8245954-1	1993	The metastable, reversible carbethoxylation of histidine in the cobalt(III) complexes (ethylene-diamine)(histidine)chlorocobalt(III) chloride, [Co(III)(en)ClHis]Cl, and (diethylenetriamine) (histidine)cobalt(III) dichloride, [Co(III)(dien)His]Cl2, following reaction with diethylpyrocarbonate, was observed using UV spectroscopy.	Histidine	47-56	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	128-131
8245954-1	1993	The metastable, reversible carbethoxylation of histidine in the cobalt(III) complexes (ethylene-diamine)(histidine)chlorocobalt(III) chloride, [Co(III)(en)ClHis]Cl, and (diethylenetriamine) (histidine)cobalt(III) dichloride, [Co(III)(dien)His]Cl2, following reaction with diethylpyrocarbonate, was observed using UV spectroscopy.	Histidine	47-56	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	226-233
8245954-1	1993	The metastable, reversible carbethoxylation of histidine in the cobalt(III) complexes (ethylene-diamine)(histidine)chlorocobalt(III) chloride, [Co(III)(en)ClHis]Cl, and (diethylenetriamine) (histidine)cobalt(III) dichloride, [Co(III)(dien)His]Cl2, following reaction with diethylpyrocarbonate, was observed using UV spectroscopy.	Histidine	105-114	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	71-74
8245954-1	1993	The metastable, reversible carbethoxylation of histidine in the cobalt(III) complexes (ethylene-diamine)(histidine)chlorocobalt(III) chloride, [Co(III)(en)ClHis]Cl, and (diethylenetriamine) (histidine)cobalt(III) dichloride, [Co(III)(dien)His]Cl2, following reaction with diethylpyrocarbonate, was observed using UV spectroscopy.	Histidine	105-114	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	128-131
8245954-1	1993	The metastable, reversible carbethoxylation of histidine in the cobalt(III) complexes (ethylene-diamine)(histidine)chlorocobalt(III) chloride, [Co(III)(en)ClHis]Cl, and (diethylenetriamine) (histidine)cobalt(III) dichloride, [Co(III)(dien)His]Cl2, following reaction with diethylpyrocarbonate, was observed using UV spectroscopy.	Histidine	105-114	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	144-151
8245954-1	1993	The metastable, reversible carbethoxylation of histidine in the cobalt(III) complexes (ethylene-diamine)(histidine)chlorocobalt(III) chloride, [Co(III)(en)ClHis]Cl, and (diethylenetriamine) (histidine)cobalt(III) dichloride, [Co(III)(dien)His]Cl2, following reaction with diethylpyrocarbonate, was observed using UV spectroscopy.	Histidine	105-114	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	128-131
8360880-4	1993	Ser-205, along with His-43 and Asp-99 make up the catalytic triad within the active site of thrombin.	Histidine	20-23	coagulation factor II, thrombin	Homo sapiens	92-100
8283388-0	1993	Commonalities in vasoactive intestinal peptide and peptide N-terminal histidine C-terminal isoleucine stimulation of N-acetyltransferase activity in the rat pineal.	Histidine	70-79	N-acetyltransferase 1	Rattus norvegicus	117-136
8395004-2	1993	The ability of spt2 mutations to suppress the transcriptional interference caused by the delta promoter insertion his-4-912 delta correlates with an increase in wild-type HIS4 mRNA levels.	Histidine	114-117	trifunctional histidinol dehydrogenase/phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase	Saccharomyces cerevisiae S288C	171-175
8395004-9	1993	The competence of these mutant SPT2 proteins to interfere with the maintenance of the His- (Spt+) phenotype of a his4-912 delta SPT2+ strain is lost by deletion of internal HMG1-like sequences and is sensitive to the wild-type SPT2+ gene dosage.	Histidine	86-89	trifunctional histidinol dehydrogenase/phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase	Saccharomyces cerevisiae S288C	113-117
8361764-4	1993	A third mutant 175 (Arg--&gt;His) bound to the p53CON but did not activate transcription.	Histidine	29-32	tumor protein p53	Homo sapiens	47-50
8394123-4	1993	The acid stabilization of insulin"s conformation was attributed to the protonation of histidine at position 5 on the B-chain (HB5) as determined by 1H-NMR of the histidines, selective amino acid alteration, and enthalpies of ionization.	Histidine	86-95	insulin	Homo sapiens	26-33
8394123-4	1993	The acid stabilization of insulin"s conformation was attributed to the protonation of histidine at position 5 on the B-chain (HB5) as determined by 1H-NMR of the histidines, selective amino acid alteration, and enthalpies of ionization.	Histidine	162-172	insulin	Homo sapiens	26-33
8344961-10	1993	A recombinant RNA helicase A containing 6 histidine residues at the NH2 terminus was expressed in Sf9 cells using a baculovirus vector.	Histidine	42-51	DExH-box helicase 9	Homo sapiens	14-28
8284256-3	1993	The primary structure of the peptide (pGlu-Leu-His-Val-Asn-Lys-Ala-Arg-Arg-Pro-Tyr-Ile-Leu) is identical to that of chicken neurotensin.	Histidine	47-50	neurotensin	Gallus gallus	124-135
8344434-1	1993	Mouse IgG1, IgG2a, and IgG2b proteins have been selectively labeled with 13C at the carbonyl carbon of His, Met, Trp or Tyr residue and used to prepare the corresponding Fc fragments by limited proteolysis.	Histidine	103-106	immunoglobulin heavy constant gamma 1 (G1m marker)	Mus musculus	6-10
8401214-8	1993	Replacement of His-33 with Ala-33 in peptide H1 alleviated a significant portion of the pH-dependent quenching of fluorescence suggesting that the interaction of the imidazole ring of His-33 with the indole ring of Trp-36 is a major determinant responsible for the quenching of the endogenous protein fluorescence of mIL-6.	Histidine	15-18	interleukin 6	Mus musculus	317-322
8251065-8	1993	Pretreatment of PEP carboxylase with diethylpyrocarbonate prevented WRK incorporation into the enzyme, suggesting that both histidine and carboxyl groups may be closely physically related.	Histidine	124-133	phosphoenolpyruvate carboxylase 2	Zea mays	16-19
8401516-0	1993	Acute intermittent porphyria caused by an arginine to histidine substitution (R26H) in the cofactor-binding cleft of porphobilinogen deaminase.	Histidine	54-63	hydroxymethylbilane synthase	Homo sapiens	117-142
8102804-2	1993	Intracerebroventricular administration of Hi at doses of 5 and 10 micrograms/kg caused a significant increase in plasma ACTH, while more rapid and more marked increase in plasma cortisol was noticed after Hi injection at doses of 2-10 micrograms/kg.	Histidine	42-44	proopiomelanocortin	Canis lupus familiaris	120-124
8102804-9	1993	From these findings, it can be concluded that intracerebroventricular injection of H(i) caused an increase in plasma ACTH and cortisol levels via H1-receptor, and it is suggested that to some extent, the cortisol release elicited by H(i) is certainly produced without participation of ACTH.	Histidine	83-87	proopiomelanocortin	Canis lupus familiaris	117-121
8102804-9	1993	From these findings, it can be concluded that intracerebroventricular injection of H(i) caused an increase in plasma ACTH and cortisol levels via H1-receptor, and it is suggested that to some extent, the cortisol release elicited by H(i) is certainly produced without participation of ACTH.	Histidine	83-87	proopiomelanocortin	Canis lupus familiaris	285-289
7687248-8	1993	Sequence analysis of the cloned histidine region, which revealed 98.6% overall homology with that of the previously analyzed prototrophic strain, showed the presence of frameshift mutations in three his genes, hisC, hisG, and hisH, and two genes unrelated to histidine biosynthesis, ORF3 and ORF6.	Histidine	32-41	orf6	Lactococcus lactis	292-296
8321192-8	1993	Within the NFKB1 portion of this fusion protein, a single amino acid change of His to Arg altered the DNA-binding specificity to favor interaction with the RelA-selective DNA motif.	Histidine	79-82	nuclear factor kappa B subunit 1	Homo sapiens	11-16
7920995-2	1993	Recently, a new GH-releasing hexapeptide (His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) called GHRP-6 which specifically releases GH has been studied.	Histidine	42-45	growth hormone 1	Homo sapiens	16-18
8100523-4	1993	VIP with terminal His-Ser was not significantly degraded by the peptidase.	Histidine	18-21	vasoactive intestinal peptide	Homo sapiens	0-3
8100523-7	1993	When human serum was incubated with GIP or GLP-1(7-36)amide the same fragments as with the purified dipeptidyl-peptidase IV, namely the des-Xaa-Ala peptides and Tyr-Ala in the case of GIP or His-Ala in the case of GLP-1(7-36)amide, were identified as the main degradation products of these peptide hormones.	Histidine	191-194	gastric inhibitory polypeptide	Homo sapiens	36-39
8332461-8	1993	EF-Gmt differs from its cytoplasmic homolog, EF-2, in that it contains an aspartic acid residue at amino acid position 621 which corresponds to the EF-2 histidine residue at position 715.	Histidine	153-162	eukaryotic translation elongation factor 2	Rattus norvegicus	45-49
8317843-0	1993	Krab domains analyzed in human Cys/His-type zinc-finger proteins KOX 1, KOX 8, and KOX 19.	Histidine	35-38	zinc finger protein 10	Homo sapiens	65-70
8317843-0	1993	Krab domains analyzed in human Cys/His-type zinc-finger proteins KOX 1, KOX 8, and KOX 19.	Histidine	35-38	zinc finger protein 25	Homo sapiens	83-89
8099556-3	1993	Here, we have systematically substituted potential metal-coordinating amino acid residues (His, Glu, Asp, Cys, Tyr, Ser) for each of the three zinc ligands of NEP using a recombinant polymerase chain reaction procedure.	Histidine	91-94	membrane metalloendopeptidase	Homo sapiens	159-162
8332461-8	1993	EF-Gmt differs from its cytoplasmic homolog, EF-2, in that it contains an aspartic acid residue at amino acid position 621 which corresponds to the EF-2 histidine residue at position 715.	Histidine	153-162	eukaryotic translation elongation factor 2	Rattus norvegicus	148-152
8503009-3	1993	The mechanism of action of L-692,429 and studies with peptidyl and nonpeptidyl antagonists suggest that this molecule is a mimic of the growth hormone-releasing hexapeptide His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 (GHRP-6).	Histidine	173-176	growth hormone 1	Homo sapiens	136-150
8212073-4	1993	This mutation is located within exon 2 and alters the codon (CTC) normally associated with Leu-93 in the transcortin polypeptide to a codon (CAC) for histidine in the variant genes.	Histidine	150-159	serpin family A member 6	Homo sapiens	105-116
8496171-1	1993	The single histidine residue (His-15) in hen egg white lysozyme (EC 3.2.1.17) was chemically modified by diethyl pyrocarbonate (DEPC) to form exclusively the mono-N-carbethoxyimidazole adduct (second order rate constant of 252 +/- 16 M-1 min-1).	Histidine	11-20	CD59 molecule (CD59 blood group)	Homo sapiens	238-243
8496171-1	1993	The single histidine residue (His-15) in hen egg white lysozyme (EC 3.2.1.17) was chemically modified by diethyl pyrocarbonate (DEPC) to form exclusively the mono-N-carbethoxyimidazole adduct (second order rate constant of 252 +/- 16 M-1 min-1).	Histidine	30-33	CD59 molecule (CD59 blood group)	Homo sapiens	238-243
8512070-2	1993	The substrate, DABCYL-gaba-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-EDANS, has been designed to incorporate the renin cleavage site that occurs in the N-terminal peptide of human angiotensinogen.	Histidine	31-34	renin	Homo sapiens	111-116
7683654-2	1993	Angiotensin I-converting enzyme (ACE, E.C.3.4.15.1) has been recently shown to contain two very similar domains, each of which bears a functional active site hydrolyzing Hip-His-Leu or angiotensin I (AI).	Histidine	174-177	angiotensin I converting enzyme	Homo sapiens	0-31
7683654-2	1993	Angiotensin I-converting enzyme (ACE, E.C.3.4.15.1) has been recently shown to contain two very similar domains, each of which bears a functional active site hydrolyzing Hip-His-Leu or angiotensin I (AI).	Histidine	174-177	angiotensin I converting enzyme	Homo sapiens	33-36
7683654-3	1993	The substrate specificity of the two active sites of ACE was compared using wild-type recombinant ACE and mutants, where one active site is suppressed by deletion or inactivated by mutations of 2 histidines coordinating an essential zinc atom.	Histidine	196-206	angiotensin I converting enzyme	Homo sapiens	53-56
8512070-2	1993	The substrate, DABCYL-gaba-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-EDANS, has been designed to incorporate the renin cleavage site that occurs in the N-terminal peptide of human angiotensinogen.	Histidine	43-46	renin	Homo sapiens	111-116
8386163-12	1993	These data provide a convincing case that the axial heme ligands of PGHS-1 are a pair of histidine residues, with the distal histidine weakly associated and possibly exchangeable with a weak-field ligand.	Histidine	89-98	prostaglandin-endoperoxide synthase 1	Homo sapiens	68-74
8489244-0	1993	Domains of rat heme oxygenase-2: the amino terminus and histidine 151 are required for heme oxidation.	Histidine	56-65	heme oxygenase 2	Rattus norvegicus	15-31
8391692-1	1993	The antisense mRNA complementary to the sense strand of Metenkephalin encodes the antisense peptides, His-Glu-Ala-Pro-Ile (compound 88/62).	Histidine	102-105	proopiomelanocortin	Homo sapiens	56-69
8386163-12	1993	These data provide a convincing case that the axial heme ligands of PGHS-1 are a pair of histidine residues, with the distal histidine weakly associated and possibly exchangeable with a weak-field ligand.	Histidine	125-134	prostaglandin-endoperoxide synthase 1	Homo sapiens	68-74
8517799-1	1993	Incubation of purified synthetic histidine-rich polypeptides, HRP-2, -3, -4, -5, -6 (histatins), with diluted human parotid saliva yielded a series of peptide degradation products whose structures could be determined by gas-phase sequencing of cationic polyacrylamide gel electroblots.	Histidine	33-42	HDGF like 2	Homo sapiens	62-83
8476863-1	1993	In previous work, we have shown that the first (and, presumably, the second) pKa of the active-site histidine-95 in triosephosphate isomerase has been lowered by about 2 units [Lodi, P. J., &amp; Knowles, J. R. (1991) Biochemistry 30, 6948-6956].	Histidine	100-109	triosephosphate isomerase 1	Homo sapiens	116-141
8470887-5	1993	In contrast, binding of thrombin to p-CBA agarose was eliminated by modification of the active site histidine using either H-D-phenylalanyl-L-prolyl-L-arginine chloromethylketone or dansyl-L-glutamyl-glycyl-L-arginine chloromethylketone but not with tosyl-L-lysine chloromethylketone.	Histidine	100-109	coagulation factor II, thrombin	Homo sapiens	24-32
8455039-0	1993	Role of histidine residues in agonist and antagonist binding sites of A1 adenosine receptor.	Histidine	8-17	adenosine A1 receptor	Sus scrofa	70-91
8454345-1	1993	Most strains of group B streptococci (GBS) elaborate a cell surface-associated enzyme that rapidly inactivates the human complement-derived chemoattractants C5a and C5adesarg by cleaving the His-Lys bond at positions 67 and 68 in the C5a molecule.	Histidine	191-194	complement C5a receptor 1	Homo sapiens	157-160
8454345-1	1993	Most strains of group B streptococci (GBS) elaborate a cell surface-associated enzyme that rapidly inactivates the human complement-derived chemoattractants C5a and C5adesarg by cleaving the His-Lys bond at positions 67 and 68 in the C5a molecule.	Histidine	191-194	complement C5a receptor 1	Homo sapiens	165-168
8468356-4	1993	Fibronectin bound specifically to the peptide Gly-Gly-Trp-Ser-His-Trp from the second type I repeat of thrombospondin but not to the corresponding peptides from the first or third repeats or flanking sequences from the second repeat.	Histidine	62-65	fibronectin 1	Homo sapiens	0-11
8440386-0	1993	Kinetic evidence that His-711 of neutral endopeptidase 24.11 is involved in stabilization of the transition state.	Histidine	22-25	neprilysin	Oryctolagus cuniculus	33-60
7681064-0	1993	Identification of the histidine residues of hemopexin that coordinate with heme-iron and of a receptor-binding region.	Histidine	22-31	hemopexin	Oryctolagus cuniculus	44-53
7681064-10	1993	The location of this epitope near the heme-binding histidine residue 127 is compatible with a transport mechanism in which the release of heme from hemopexin is accompanied by a concomitant transfer of heme to the hemopexin receptor or the membrane heme-binding protein (Smith, A., and Morgan, W. T. (1985) J. Biol.	Histidine	51-60	hemopexin	Oryctolagus cuniculus	148-157
7681064-10	1993	The location of this epitope near the heme-binding histidine residue 127 is compatible with a transport mechanism in which the release of heme from hemopexin is accompanied by a concomitant transfer of heme to the hemopexin receptor or the membrane heme-binding protein (Smith, A., and Morgan, W. T. (1985) J. Biol.	Histidine	51-60	hemopexin	Oryctolagus cuniculus	214-223
8440386-2	1993	NEP can be inactivated by reaction with diethylpyrocarbonate, due to the modification of a histidine residue present in the active site of the enzyme.	Histidine	91-100	neprilysin	Oryctolagus cuniculus	0-3
8427859-0	1993	Glutamine/histidine polymorphism in apo A-IV affects plasma concentrations of lipoprotein(a) and fibrin split products in coronary heart disease patients.	Histidine	10-19	apolipoprotein A4	Homo sapiens	36-44
8381406-2	1993	An anilinonaphthalene-6-sulfonic acid (ANS) dye was attached covalently to the active site histidine of thrombin via a D-Phe-Pro-Arg (FPR) linkage to form ANS-FPR-thrombin.	Histidine	91-100	coagulation factor II, thrombin	Homo sapiens	104-112
8381406-2	1993	An anilinonaphthalene-6-sulfonic acid (ANS) dye was attached covalently to the active site histidine of thrombin via a D-Phe-Pro-Arg (FPR) linkage to form ANS-FPR-thrombin.	Histidine	91-100	coagulation factor II, thrombin	Homo sapiens	163-171
24190643-4	1993	Purification of CBP by HPLC yielded four protein peaks, of which one bound histidine exclusively.	Histidine	75-84	CREB binding protein	Homo sapiens	16-19
24190643-7	1993	These data show that commercially available CBP is not a homogenous protein; it contains a histidine as well as a cystine binding component.	Histidine	91-100	CREB binding protein	Homo sapiens	44-47
8428931-6	1993	Mutants of 5-lipoxygenase, with substitutions of these 6 conserved histidines, were purified and analyzed.	Histidine	67-77	arachidonate 5-lipoxygenase	Homo sapiens	11-25
8428931-10	1993	We conclude that histidines 372 and 550 constitute two of the iron ligands in 5-lipoxygenase.	Histidine	17-27	arachidonate 5-lipoxygenase	Homo sapiens	78-92
8383439-7	1993	Among the natural peptides structurally related to VIP, some inhibited 125I-VIP binding with the following order of potency: VIP = pituitary adenylate cyclase-activating peptide (PACAP)-27 = PACAP-38 &gt; helodermin &gt;&gt; peptide histidine methionineamide = human growth hormone-releasing factor &gt; secretin.	Histidine	233-242	vasoactive intestinal peptide	Homo sapiens	51-54
8383439-7	1993	Among the natural peptides structurally related to VIP, some inhibited 125I-VIP binding with the following order of potency: VIP = pituitary adenylate cyclase-activating peptide (PACAP)-27 = PACAP-38 &gt; helodermin &gt;&gt; peptide histidine methionineamide = human growth hormone-releasing factor &gt; secretin.	Histidine	233-242	vasoactive intestinal peptide	Homo sapiens	76-79
8383439-7	1993	Among the natural peptides structurally related to VIP, some inhibited 125I-VIP binding with the following order of potency: VIP = pituitary adenylate cyclase-activating peptide (PACAP)-27 = PACAP-38 &gt; helodermin &gt;&gt; peptide histidine methionineamide = human growth hormone-releasing factor &gt; secretin.	Histidine	233-242	vasoactive intestinal peptide	Homo sapiens	76-79
7510502-4	1993	The recently demonstrated presence of 4 basic amino acids (1 arginine, 3 histidine) in the cleaved fragment of the amyloid precursor protein (APP) suggest us to hypothesise that this APP portion may represent the common constitutive element of the many morphologically different alterations found in the brains of senile demented patients.	Histidine	73-82	amyloid beta precursor protein	Homo sapiens	115-140
8427859-1	1993	A glutamine/histidine polymorphism at residue 360 in apolipoprotein (apo) A-IV that generates two electrophoretically detectable isoforms, apo A-IV-1 and apo A-IV-2, affects the plasma concentration of lipoprotein(a) (Lp[a]) in a healthy population.	Histidine	12-21	apolipoprotein A4	Homo sapiens	53-78
8427859-1	1993	A glutamine/histidine polymorphism at residue 360 in apolipoprotein (apo) A-IV that generates two electrophoretically detectable isoforms, apo A-IV-1 and apo A-IV-2, affects the plasma concentration of lipoprotein(a) (Lp[a]) in a healthy population.	Histidine	12-21	apolipoprotein A4	Homo sapiens	139-147
8427859-1	1993	A glutamine/histidine polymorphism at residue 360 in apolipoprotein (apo) A-IV that generates two electrophoretically detectable isoforms, apo A-IV-1 and apo A-IV-2, affects the plasma concentration of lipoprotein(a) (Lp[a]) in a healthy population.	Histidine	12-21	apolipoprotein A4	Homo sapiens	154-162
7678159-8	1993	In addition, structurally related non-histidine containing renin inhibitors showed absolutely no increase in the number of revertant colonies.	Histidine	38-47	renin	Homo sapiens	59-64
8381821-17	1993	The ARG-311-HIS mutation may contribute to PRTH in patient G.H.	Histidine	12-15	thyroid hormone receptor beta	Homo sapiens	43-47
7678159-10	1993	A second line of evidence showing parallelism to growth enhancing compounds concerns the comutagenicity of histidine containing renin inhibitors.	Histidine	107-116	renin	Homo sapiens	128-133
1447196-15	1992	Like the bacterial proteins, QPs1 has 2 conserved histidines at positions 34 and 90.	Histidine	50-60	succinate dehydrogenase complex subunit C	Bos taurus	29-33
8096552-7	1993	Comparison of the amino acid residues of DRB1 chain suggested that the basic amino acid at position 13, which is present only on the DR2 and DR4 B1 molecules (Arg on DR2 and His on DR4), contributes to the susceptibility to autoimmune hepatitis among Japanese.	Histidine	174-177	major histocompatibility complex, class II, DR beta 1	Homo sapiens	41-45
8019921-4	1993	Direct sequencing showed a G-A point mutation at position 2818 of exon 7 responsible for an arginine-histidine substitution at position 840 of the androgen receptor.	Histidine	101-110	androgen receptor	Homo sapiens	147-164
1465386-5	1992	By mutating each individual residue within this sequence to alanine, three residues (Tyr-440, Asp-441, and His-444) were identified as being critical for IFN-gamma-dependent (i) upregulation of major histocompatibility complex class I proteins, (ii) activation of the IFN regulatory factor 1 gene, and (iii) stimulation of cells to produce nitric oxide.	Histidine	107-110	interferon gamma	Homo sapiens	154-163
1283743-3	1992	As a result of this study a series of low-energy conformations were identified showing a common folding pattern with residues Val-3, Pro-4, His-5 and Lys-6 forming a beta turn.	Histidine	140-143	amyloid beta precursor protein	Homo sapiens	164-170
1332771-5	1992	The affinity of calmodulin for the C-terminal domains of isoforms 1a, 1c, and 1d, which contain the histidine-rich inserts, is much higher at pH 5.9 than at pH 7.2.	Histidine	100-109	calmodulin 1	Homo sapiens	16-26
1452354-1	1992	Compositional analysis of streptococcal C5a peptidase (SCPA) cleavage products from a synthetic peptide corresponding to the 20 C-terminal residues of C5a demonstrated that the target cleavage site is His-Lys rather than Lys-Asp, as previously suggested.	Histidine	201-204	complement C5a receptor 1	Homo sapiens	40-43
1452354-1	1992	Compositional analysis of streptococcal C5a peptidase (SCPA) cleavage products from a synthetic peptide corresponding to the 20 C-terminal residues of C5a demonstrated that the target cleavage site is His-Lys rather than Lys-Asp, as previously suggested.	Histidine	201-204	complement C5a receptor 1	Homo sapiens	151-154
1332771-4	1992	The positive charges of histidine residues at positions 27, 28, and 38 of the alternatively spliced sequence are likely to be responsible for the observed pH-dependent calmodulin binding to the novel "duplicated" binding site.	Histidine	24-33	calmodulin 1	Homo sapiens	168-178
1280325-5	1992	Zinc may stabilize the DNA-binding domain of MyTI by coordinating three cysteine and one histidine residue in a Cys-X5-Cys-X12-His-X4-Cys (C2-HC) arrangement.	Histidine	89-98	myelin transcription factor 1	Homo sapiens	45-49
1280325-5	1992	Zinc may stabilize the DNA-binding domain of MyTI by coordinating three cysteine and one histidine residue in a Cys-X5-Cys-X12-His-X4-Cys (C2-HC) arrangement.	Histidine	127-130	myelin transcription factor 1	Homo sapiens	45-49
1384695-5	1992	A peptide containing a single arginine within a stretch of histidines (CYHHHRHHHHHA) shows pH-dependent binding and a corresponding change in TAR conformation, as detected by a decrease in the CD signal at 265 nm.	Histidine	59-69	RNA binding motif protein 8A	Homo sapiens	142-145
1421398-0	1992	Prothrombin Himi: a compound heterozygote for two dysfunctional prothrombin molecules (Met-337--&gt;Thr and Arg-388--&gt;His).	Histidine	121-124	coagulation factor II, thrombin	Homo sapiens	0-11
1421398-0	1992	Prothrombin Himi: a compound heterozygote for two dysfunctional prothrombin molecules (Met-337--&gt;Thr and Arg-388--&gt;His).	Histidine	121-124	coagulation factor II, thrombin	Homo sapiens	64-75
1282482-5	1992	Neuropeptide gamma was the most abundant peptide and its primary structure was established as Asp-Ala-Gly-Tyr-Gly-Gln-Ile-Ser-His-Lys-Arg-His-Lys-Thr-Asp-Ser- Phe-Val-Gly-Leu-Met-NH2.	Histidine	126-129	tachykinin precursor 1	Homo sapiens	0-18
1429680-5	1992	Ubp2 (1,264 residues), Ubp3 (912 residues), and the previously cloned Ubp1 (809 residues) are largely dissimilar except for two short regions containing Cys and His which encompass their putative active sites.	Histidine	161-164	ubiquitin-specific protease UBP1	Saccharomyces cerevisiae S288C	70-74
1443599-1	1992	The angiotensin I-based peptide Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Leu-Glu-Glu-Ser yields angiotensin I (Ang I) and Leu-Glu-Glu-Ser upon hydrolysis by the human immunodeficiency virus type 1 (HIV-1) protease, but not by human renin.	Histidine	52-55	renin	Homo sapiens	231-236
1424279-6	1992	Addition of inhibitors to the chemiluminescence system demonstrated that the chemiluminescence response was inhibited by azide and salicylhydroxamic acid and reduced by histidine, suggesting that the chemiluminescence response was due to activation of myeloperoxidase, with generation of singlet oxygen.	Histidine	169-178	myeloperoxidase	Homo sapiens	252-267
1517212-2	1992	Evidence for the involvement of Ser-203, His-447, and Glu-334 in the catalytic triad of human acetylcholinesterase was provided by substitution of these amino acids by alanine residues.	Histidine	41-44	acetylcholinesterase (Cartwright blood group)	Homo sapiens	94-114
1390778-2	1992	We previously identified five such mutations located in the extracellular domain of the insulin receptor (Asn--&gt;Lys15, His--&gt;Arg209, Phe--&gt;Val382, Lys--&gt;Glu460, and Asn--&gt;Ser462) and studied the effects of these mutations upon posttranslational processing, insulin binding, and tyrosine autophosphorylation.	Histidine	122-125	insulin	Homo sapiens	88-95
1390944-0	1992	Hemoglobin Rouen (alpha-140 (HC2) Tyr-->His): alteration of the alpha-chain C-terminal region and moderate increase in oxygen affinity.	Histidine	40-43	Fc gamma receptor and transporter	Homo sapiens	64-75
1400881-1	1992	The synthetic GH-releasing hexapeptide (GHRP: His-DTrp-Ala-Trp-DPhe-Lys-NH2) releases GH in man by an undetermined mechanism.	Histidine	46-49	growth hormone 1	Homo sapiens	14-16
1400881-1	1992	The synthetic GH-releasing hexapeptide (GHRP: His-DTrp-Ala-Trp-DPhe-Lys-NH2) releases GH in man by an undetermined mechanism.	Histidine	46-49	growth hormone 1	Homo sapiens	40-42
1333573-0	1992	A further study on the stimulatory effect of peptide histidine methionine on growth hormone secretion in acromegaly: a dose-related study and a comparison with vasoactive intestinal peptide.	Histidine	53-62	growth hormone 1	Homo sapiens	77-91
1510947-6	1992	Edman degradation of the two labeled peptides showed a single sequence His-Pro-Ile-([3H]X)-Arg corresponding to the pentapeptide His-Pro-Ile-Met-Arg 136-140 of SHBG sequence.	Histidine	71-74	sex hormone binding globulin	Homo sapiens	160-164
1379790-4	1992	Unlike human apo C-I, mature rat apo C-I contains histidine, lacks valine, and has alanine at the C terminus and aspartate as the N terminus.	Histidine	50-59	apolipoprotein C1	Rattus norvegicus	33-40
1511742-2	1992	Zinc fingers of the transcription factor IIIA (TFIIIA) type, in which zinc is co-ordinated by two cysteine and two histidine ligands (Cys2/His2), contain a length of helix packed against a beta-hairpin.	Histidine	115-124	general transcription factor IIIA	Homo sapiens	20-45
1511742-2	1992	Zinc fingers of the transcription factor IIIA (TFIIIA) type, in which zinc is co-ordinated by two cysteine and two histidine ligands (Cys2/His2), contain a length of helix packed against a beta-hairpin.	Histidine	115-124	general transcription factor IIIA	Homo sapiens	47-53
1511750-5	1992	The three mutant antibodies showed different and characteristic patterns of pH-dependent binding to lysozyme, which depended on the location of the artificially introduced histidine residues.	Histidine	172-181	lysozyme	Homo sapiens	100-108
1510947-6	1992	Edman degradation of the two labeled peptides showed a single sequence His-Pro-Ile-([3H]X)-Arg corresponding to the pentapeptide His-Pro-Ile-Met-Arg 136-140 of SHBG sequence.	Histidine	129-132	sex hormone binding globulin	Homo sapiens	160-164
1511986-4	1992	Hb Zaire [alpha 116(GH4)-His-Leu-Pro-Ala-Glu-117 (GH5)] is the second example in which a short amino acid sequence is inserted within the alpha-chain.	Histidine	25-28	Fc gamma receptor and transporter	Homo sapiens	138-149
1510660-0	1992	The characterization of 5 histidine-serine mutants of human 5-lipoxygenase.	Histidine	26-35	arachidonate 5-lipoxygenase	Homo sapiens	60-74
1510660-1	1992	The physical and catalytic properties of 5 histidine-serine mutants of human 5-lipoxygenase (5-LO) have been characterized.	Histidine	43-52	arachidonate 5-lipoxygenase	Homo sapiens	77-91
1417919-4	1992	Chemical modification of this aminopeptidase by several amino acid-modifying agents indicated essential lysine, histidine, arginine, cysteine, and tyrosine residues.	Histidine	112-121	carboxypeptidase Q	Homo sapiens	30-44
1499089-2	1992	The reaction products after in vitro incubation of Angiotensin I with styrene oxide, a well known carcinogen, under different conditions, have been characterized: a prominent reactivity of several potential nucleophilic sites of Angiotensin I was shown, including two histidine residues and a tyrosine residue; it is worth noting that it has never been stated that tyrosine is highly reactive with styrene oxide.	Histidine	268-277	angiotensinogen	Homo sapiens	51-64
1499089-2	1992	The reaction products after in vitro incubation of Angiotensin I with styrene oxide, a well known carcinogen, under different conditions, have been characterized: a prominent reactivity of several potential nucleophilic sites of Angiotensin I was shown, including two histidine residues and a tyrosine residue; it is worth noting that it has never been stated that tyrosine is highly reactive with styrene oxide.	Histidine	268-277	angiotensinogen	Homo sapiens	229-242
1619012-6	1992	Previously, others have reported a kindred with GRTH, in that the same codon was subjected to proline to histidine replacement due to a mutation consisting of a cytosine to adenine replacement at nucleotide position 1643.	Histidine	105-114	thyroid hormone receptor beta	Homo sapiens	48-52
1497657-0	1992	Identification of the iron-binding histidine residues in soybean lipoxygenase L-1.	Histidine	35-44	seed linoleate 13S-lipoxygenase-1	Glycine max	65-81
1497657-4	1992	We had previously obtained mutant proteins in which each of the 6 conserved histidines of soybean lipoxygenase L-1 had been replaced and found that the mutants H499Q, H504Q (or H504S) and H690Q had no detectable enzymatic activity.	Histidine	76-86	seed linoleate 13S-lipoxygenase-1	Glycine max	98-114
1385391-9	1992	An oligopeptide containing the sequence around Thr-19 of bovine myelin basic protein, Lys-Tyr-Leu-Ala-Ser-Ala-Ser-Thr(19)-Met-Asp-His-Ala, can be used as a substrate for selective assaying of the yeast PKC.	Histidine	130-133	myelin basic protein	Bos taurus	64-84
1634535-7	1992	The incorporated label was localized to a 9000 molecular weight region of alpha and beta/gamma-thrombin containing the catalytic-site histidine residue.	Histidine	134-143	coagulation factor II, thrombin	Homo sapiens	95-103
1592884-1	1992	Intravenous infusions of the synthetic hexapeptide GH-releasing peptide (His-DTrp-Ala-Trp-DPhe-Lys-NH2; GHRP) specifically stimulate GH release in man.	Histidine	73-76	growth hormone 1	Homo sapiens	51-53
16668920-2	1992	Here, we report that maize cell suspension cultures yield a new extensin rich in histidine (HHRGP) that also has characteristics of arabinogalactan proteins (AGPs).	Histidine	81-90	Protein PYRICULARIA ORYZAE RESISTANCE 21	Zea mays	64-72
1551909-4	1992	In addition, complex formation with C1s was detected for P1-Asn and P1-His.	Histidine	71-74	complement C1s	Homo sapiens	36-39
1567910-8	1992	In the present study we investigated the interaction of native PLA2 and of an inactive PLA2 in which the active site residue His-48 has been modified by alkylation with 1-bromo-2-octanone, with pure micelles of several of these inhibitors in both enantiomeric forms by means of ultraviolet difference absorption spectroscopy.	Histidine	125-128	phospholipase A2 group IB	Homo sapiens	87-91
1524216-3	1992	The hydrolysis of Abz-His-Pro-Phe-His-Leu-Val-Ile-His-EDDnp by human renin was inhibited by a highly specific transition-state analog of angiotensinogen (IC50 = 7.8 x 10(-9) M), described by K. Iizuka et al.	Histidine	22-25	renin	Homo sapiens	69-74
1524216-3	1992	The hydrolysis of Abz-His-Pro-Phe-His-Leu-Val-Ile-His-EDDnp by human renin was inhibited by a highly specific transition-state analog of angiotensinogen (IC50 = 7.8 x 10(-9) M), described by K. Iizuka et al.	Histidine	22-25	angiotensinogen	Homo sapiens	137-152
1524216-7	1992	Therefore, specific and sensitive substrates for the continuous assay of human renin in which as little as 70 microGU of human renin could be detected by Abz-Phe-His-Leu-Val-Ile-His-EDDnp were described.	Histidine	162-165	renin	Homo sapiens	79-84
1524216-7	1992	Therefore, specific and sensitive substrates for the continuous assay of human renin in which as little as 70 microGU of human renin could be detected by Abz-Phe-His-Leu-Val-Ile-His-EDDnp were described.	Histidine	162-165	renin	Homo sapiens	127-132
1551909-6	1992	Electrophoretic studies confirmed that P1-Lys and P1-His can form sodium dodecyl sulfate-resistant complexes with C1s.	Histidine	53-56	complement C1s	Homo sapiens	114-117
1313648-5	1992	In the experiments for assessing the effect of various scavengers, 1O2 scavenger histidine or iron chelator deferoxamine effectively protected the attenuation induced by DHF/Fe(3+)-ADP exposure of the relaxation elicited by acetylcholine; superoxide dismutase (SOD), catalase, or dimethyl sulfoxide (DMSO) had no effect on this system.	Histidine	81-90	catalase	Canis lupus familiaris	267-275
1409546-5	1992	Sequencing the plasmid DNA encoding this mutant protein showed that the histidine at position 111 of native human IFN gamma is changed to aspartic acid (IFN gamma/H111D).	Histidine	72-81	interferon gamma	Homo sapiens	114-123
1409546-5	1992	Sequencing the plasmid DNA encoding this mutant protein showed that the histidine at position 111 of native human IFN gamma is changed to aspartic acid (IFN gamma/H111D).	Histidine	72-81	interferon gamma	Homo sapiens	114-119
1316850-1	1992	Angiotensin-I-converting enzyme (ACE) is a peptidyl-dipeptide hydrolase which splits off the dipeptide His-Leu from the decapeptide angiotensin I and thus converts it to angiotensin II.	Histidine	103-106	angiotensin I converting enzyme	Homo sapiens	0-31
1316850-1	1992	Angiotensin-I-converting enzyme (ACE) is a peptidyl-dipeptide hydrolase which splits off the dipeptide His-Leu from the decapeptide angiotensin I and thus converts it to angiotensin II.	Histidine	103-106	angiotensin I converting enzyme	Homo sapiens	33-36
1316850-1	1992	Angiotensin-I-converting enzyme (ACE) is a peptidyl-dipeptide hydrolase which splits off the dipeptide His-Leu from the decapeptide angiotensin I and thus converts it to angiotensin II.	Histidine	103-106	angiotensinogen	Homo sapiens	132-145
1316850-1	1992	Angiotensin-I-converting enzyme (ACE) is a peptidyl-dipeptide hydrolase which splits off the dipeptide His-Leu from the decapeptide angiotensin I and thus converts it to angiotensin II.	Histidine	103-106	angiotensinogen	Homo sapiens	170-184
1532320-0	1992	Histidine residues regulate the transition of photoexcited rhodopsin to its active conformation, metarhodopsin II.	Histidine	0-9	rhodopsin	Homo sapiens	59-68
1563042-1	1992	The hts1.1 temperature-sensitive histidinyl-tRNA synthetase mutation enables Saccharomyces cerevisiae to be starved for His-tRNAHis by upshift to the non-permissive temperature of 38 degrees C. If yeast behaves similarly to bacterial and mammalian cells, this lack of His-tRNAHis should greatly enhance misreading at histidine codons (CAU/CAC) by Gln-tRNAGln, resulting in substitution of the neutral amino acid glutamine in place of histidine, a basic amino acid.	Histidine	120-123	histidine--tRNA ligase	Saccharomyces cerevisiae S288C	4-8
1563042-1	1992	The hts1.1 temperature-sensitive histidinyl-tRNA synthetase mutation enables Saccharomyces cerevisiae to be starved for His-tRNAHis by upshift to the non-permissive temperature of 38 degrees C. If yeast behaves similarly to bacterial and mammalian cells, this lack of His-tRNAHis should greatly enhance misreading at histidine codons (CAU/CAC) by Gln-tRNAGln, resulting in substitution of the neutral amino acid glutamine in place of histidine, a basic amino acid.	Histidine	317-326	histidine--tRNA ligase	Saccharomyces cerevisiae S288C	4-8
1563042-1	1992	The hts1.1 temperature-sensitive histidinyl-tRNA synthetase mutation enables Saccharomyces cerevisiae to be starved for His-tRNAHis by upshift to the non-permissive temperature of 38 degrees C. If yeast behaves similarly to bacterial and mammalian cells, this lack of His-tRNAHis should greatly enhance misreading at histidine codons (CAU/CAC) by Gln-tRNAGln, resulting in substitution of the neutral amino acid glutamine in place of histidine, a basic amino acid.	Histidine	434-443	histidine--tRNA ligase	Saccharomyces cerevisiae S288C	4-8
1541289-14	1992	From the amino acid compositions, it appears that all six proteins are rich in arginine, cysteine and histidine and are closely related to pmP2 and mP2.	Histidine	102-111	proline rich protein HaeIII subfamily 1	Mus musculus	140-143
1490689-0	1992	Effect of the infusion of p-Glu-His-Ala-OH, analog of the anorexigenic peptide, on the insulin response induced by intravenous glucose.	Histidine	32-35	insulin	Homo sapiens	87-94
1540191-6	1992	These results strongly suggest that His-367, His-372, His-550 and Glu-376 are crucial for 5-lipoxygenase activity and coordinate to the essential iron.	Histidine	36-39	arachidonate 5-lipoxygenase	Homo sapiens	90-104
1540191-6	1992	These results strongly suggest that His-367, His-372, His-550 and Glu-376 are crucial for 5-lipoxygenase activity and coordinate to the essential iron.	Histidine	45-48	arachidonate 5-lipoxygenase	Homo sapiens	90-104
1540191-6	1992	These results strongly suggest that His-367, His-372, His-550 and Glu-376 are crucial for 5-lipoxygenase activity and coordinate to the essential iron.	Histidine	45-48	arachidonate 5-lipoxygenase	Homo sapiens	90-104
1732557-0	1992	Improvements in the minimum binding sequence of C5a: examination of His-67.	Histidine	68-71	complement C5a receptor 1	Homo sapiens	48-51
1731317-3	1992	Six conserved histidine residues in 5-lipoxygenase were subjected to site-directed mutagenesis.	Histidine	14-23	arachidonate 5-lipoxygenase	Homo sapiens	36-50
1731317-7	1992	Thus, the histidines in the first group (His-367, -372, -551) were crucial for 5-lipoxygenase activity, possibly because of a function of these residues as metal ligands.	Histidine	10-20	arachidonate 5-lipoxygenase	Homo sapiens	79-93
1731317-7	1992	Thus, the histidines in the first group (His-367, -372, -551) were crucial for 5-lipoxygenase activity, possibly because of a function of these residues as metal ligands.	Histidine	41-44	arachidonate 5-lipoxygenase	Homo sapiens	79-93
1427020-1	1992	Human apolipoprotein A-IV (APO A-IV) exhibits a common protein polymorphism detectable by isoelectric focusing (IEF) due to a single base substitution at codon 360 which replaces the frequently occurring glutamine residue (allele 1) with histidine (allele 2).	Histidine	238-247	apolipoprotein A4	Homo sapiens	6-25
1427020-1	1992	Human apolipoprotein A-IV (APO A-IV) exhibits a common protein polymorphism detectable by isoelectric focusing (IEF) due to a single base substitution at codon 360 which replaces the frequently occurring glutamine residue (allele 1) with histidine (allele 2).	Histidine	238-247	apolipoprotein A4	Homo sapiens	27-35
1543503-0	1992	Site-directed mutagenesis of His-42, His-188 and Lys-263 of human aldose reductase.	Histidine	29-32	aldo-keto reductase family 1 member B	Homo sapiens	66-82
1543503-0	1992	Site-directed mutagenesis of His-42, His-188 and Lys-263 of human aldose reductase.	Histidine	37-40	aldo-keto reductase family 1 member B	Homo sapiens	66-82
1505532-1	1992	A mutation spectrum was constructed from a series of randomly isolated spontaneous His+ revertants of the frameshift mutant his4-38 in Saccharomyces cerevisiae.	Histidine	83-86	trifunctional histidinol dehydrogenase/phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase	Saccharomyces cerevisiae S288C	124-128
1505532-5	1992	Of the bases encompassing the his4-38 region from +153-181, approximately 45% were not involved in a reversion event, although a -1 frameshift within this region will result in a viable His+ revertant.	Histidine	186-189	trifunctional histidinol dehydrogenase/phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase	Saccharomyces cerevisiae S288C	30-34
1350267-5	1992	These findings suggest that the DR4-specific sequence (Val 11 and His 13 at amino acid positions 11 and 13, respectively), but not particular Dw-associated DR4 sequence, in the first domain of the DRB1 chain contributes to susceptibility to autoimmune hepatitis among Japanese.	Histidine	66-69	major histocompatibility complex, class II, DR beta 1	Homo sapiens	197-201
1428012-4	1992	Residue 171, which is part of the alpha 2 helix, is believed to contribute directly to peptide interaction in the A pocket of the binding groove and is either histidine or tyrosine in all HLA-A, B, C heavy chains.	Histidine	159-168	major histocompatibility complex, class I, A	Homo sapiens	188-196
1309593-5	1992	Analysis of full-length UCRBP cDNA reveals that it has a putative zinc finger domain composed of four C2H2 zinc fingers of the GLI subgroup and an N-terminal region containing alternating charges, including a stretch of 12 histidine residues.	Histidine	223-232	YY1 transcription factor	Homo sapiens	24-29
1764475-3	1991	The NMR spectral comparison of paramagnetically shifted resonances with those of the well characterized horseradish peroxidase C, HRP(C), isoenzyme indicates that both cucumber peroxidases have a protohemin IX prosthetic group with proximal histidine coordinated to the heme iron.	Histidine	241-250	peroxidase 2-like	Cucumis sativus	116-126
1661588-2	1991	Native HGF and mutant HGFs, in which Gln534 and/or Tyr673 were respectively substituted for His and Ser to coincide with the catalytic triad amino acids in plasmin, markedly stimulated DNA synthesis of hepatocytes and scattering of MDCK cells but inhibited DNA synthesis of HepG2 cells.	Histidine	92-95	hepatocyte growth factor	Canis lupus familiaris	7-10
1304876-1	1992	The histidine-glycine-rich region of the light chain of cleaved high molecular weight kininogen (HK) is thought to be responsible for binding to negatively charged surfaces and initiation of the intrinsic coagulation, fibrinolytic, and kinin-forming systems.	Histidine	4-13	kininogen 1	Homo sapiens	64-95
1667880-3	1991	In the recently discovered family of self-cleaving proteins exemplified by the LexA repressor of Escherichia coli, instead of the imidazole of a histidine, the active-site general-base catalyst was found to be the epsilon-amino of a lysine.	Histidine	145-154	DNA repair system	Escherichia coli	79-83
1799223-3	1991	We considered whether a commercially available synthetic tetradecapeptide (TDP), Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Leu-Val-Tyr-Ser, would produce authentic Ang I upon incubation with protease from human immunodeficiency virus type 1 (HIV-1).	Histidine	101-104	angiotensinogen	Homo sapiens	162-167
1657998-3	1991	We have used site-directed mutagenesis of the Saccharomyces cerevisiae Rieske iron-sulfur protein gene (RIP 1) to convert cysteines 159, 164, 178, and 180 to serines, and to convert histidines 161 and 181 to arginines.	Histidine	182-192	ubiquinol--cytochrome-c reductase catalytic subunit RIP1	Saccharomyces cerevisiae S288C	104-109
1657933-4	1991	After characterization of the C-terminal region, and in contrast to what could be expected from previously published spectroscopic analyses, the N-terminal region 1-152 of rubrerythrin appears to have no sequence similarity with the eukaryotic protein hemerythrin which is known to contain a binuclear iron center bound by 5 histidine ligands.	Histidine	325-334	rr	Desulfovibrio vulgaris str. Hildenborough	172-184
1657933-5	1991	However, the N-terminal region of rubrerythrin does contain 5 histidine residues but they are differently spaced along the peptide chain.	Histidine	62-71	rr	Desulfovibrio vulgaris str. Hildenborough	34-46
1657933-6	1991	We suggest that at least one of the 3 histidine residues located in the rubredoxin-like center of rubrerythrin may be liganded to one iron atom of the hemerythrin-like center.	Histidine	38-47	rr	Desulfovibrio vulgaris str. Hildenborough	98-110
1939225-0	1991	Evaluation of the role of conserved His and Met residues among lipoxygenases by site-directed mutagenesis of recombinant human 5-lipoxygenase.	Histidine	36-39	arachidonate 5-lipoxygenase	Homo sapiens	127-141
1939225-3	1991	After single mutation of each of the 5 His residues at positions 363, 368, 373, 391, and 400 by Ser, Cys, or Lys, measurable levels of 5-lipoxygenase activity could be recovered in Escherichia coli only for the Ser363 and Cys363 mutants, with most amino acid substitutions causing a decrease in the levels of expression of the soluble protein.	Histidine	39-42	arachidonate 5-lipoxygenase	Homo sapiens	135-149
1799223-3	1991	We considered whether a commercially available synthetic tetradecapeptide (TDP), Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Leu-Val-Tyr-Ser, would produce authentic Ang I upon incubation with protease from human immunodeficiency virus type 1 (HIV-1).	Histidine	113-116	angiotensinogen	Homo sapiens	162-167
1918036-1	1991	Human heart chymase, a chymotrypsin-like serine proteinase that hydrolyzes the Phe8-His9 bond in angiotensin I (Ang I) to yield the octapeptide hormone angiotensin II (Ang II) and His-Leu, is the most specific, efficient Ang II-forming enzyme described.	Histidine	84-87	chymase 1	Homo sapiens	12-19
1667689-6	1991	The major form of Anolis alpha-MSH is nonacetylated and has the following novel primary sequence: Ser-Tyr-Ala-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro(Val-amide).	Histidine	118-121	alpha-msh	Anolis carolinensis	25-34
1918036-1	1991	Human heart chymase, a chymotrypsin-like serine proteinase that hydrolyzes the Phe8-His9 bond in angiotensin I (Ang I) to yield the octapeptide hormone angiotensin II (Ang II) and His-Leu, is the most specific, efficient Ang II-forming enzyme described.	Histidine	84-87	angiotensinogen	Homo sapiens	97-110
1918036-1	1991	Human heart chymase, a chymotrypsin-like serine proteinase that hydrolyzes the Phe8-His9 bond in angiotensin I (Ang I) to yield the octapeptide hormone angiotensin II (Ang II) and His-Leu, is the most specific, efficient Ang II-forming enzyme described.	Histidine	84-87	angiotensinogen	Homo sapiens	112-117
1918036-1	1991	Human heart chymase, a chymotrypsin-like serine proteinase that hydrolyzes the Phe8-His9 bond in angiotensin I (Ang I) to yield the octapeptide hormone angiotensin II (Ang II) and His-Leu, is the most specific, efficient Ang II-forming enzyme described.	Histidine	84-87	angiotensinogen	Homo sapiens	152-166
1659346-5	1991	DM elicited a significant decrease in plasma ACE activity (from 0.46 +/- 0.03 to 0.28 +/- 0.02 nmol His-Leu/min/mg protein) but did not alter enzyme activity in the brush border: 47.12 +/- 5.12 nmol His-Leu/min/mg protein (control, n = 6) and 47.78 +/- 5.63 (DM, n = 6).	Histidine	100-103	angiotensin I converting enzyme	Rattus norvegicus	45-48
1797705-1	1991	The N-terminal heptadecapeptide of human angiotensinogen (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Asn-Glu-Ser-Thr-NH2 ), with the C-terminal carboxyl group amidated, was synthesized in order to study the role of Asn-Glu-Ser, a putative carbohydrate binding site, on the hydrolysis by human renin.	Histidine	78-81	angiotensinogen	Homo sapiens	41-56
1797705-1	1991	The N-terminal heptadecapeptide of human angiotensinogen (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Asn-Glu-Ser-Thr-NH2 ), with the C-terminal carboxyl group amidated, was synthesized in order to study the role of Asn-Glu-Ser, a putative carbohydrate binding site, on the hydrolysis by human renin.	Histidine	78-81	renin	Homo sapiens	302-307
1797705-1	1991	The N-terminal heptadecapeptide of human angiotensinogen (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Asn-Glu-Ser-Thr-NH2 ), with the C-terminal carboxyl group amidated, was synthesized in order to study the role of Asn-Glu-Ser, a putative carbohydrate binding site, on the hydrolysis by human renin.	Histidine	90-93	angiotensinogen	Homo sapiens	41-56
1797705-1	1991	The N-terminal heptadecapeptide of human angiotensinogen (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Asn-Glu-Ser-Thr-NH2 ), with the C-terminal carboxyl group amidated, was synthesized in order to study the role of Asn-Glu-Ser, a putative carbohydrate binding site, on the hydrolysis by human renin.	Histidine	90-93	renin	Homo sapiens	302-307
1797705-1	1991	The N-terminal heptadecapeptide of human angiotensinogen (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Asn-Glu-Ser-Thr-NH2 ), with the C-terminal carboxyl group amidated, was synthesized in order to study the role of Asn-Glu-Ser, a putative carbohydrate binding site, on the hydrolysis by human renin.	Histidine	90-93	angiotensinogen	Homo sapiens	41-56
1797705-1	1991	The N-terminal heptadecapeptide of human angiotensinogen (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Asn-Glu-Ser-Thr-NH2 ), with the C-terminal carboxyl group amidated, was synthesized in order to study the role of Asn-Glu-Ser, a putative carbohydrate binding site, on the hydrolysis by human renin.	Histidine	90-93	renin	Homo sapiens	302-307
1799412-6	1991	A novel derivative of the fluorogenic substrate, containing a 3-methyl histidine substitution at the P2 site, was used to test the recent hypothesis that renin functions by virtue of substrate-directed catalysis.	Histidine	71-80	renin	Homo sapiens	154-159
1716370-0	1991	The peptide Glu-His-Ile-Pro-Ala binds fibrinogen and inhibits platelet aggregation and adhesion to fibrinogen and vitronectin.	Histidine	16-19	fibrinogen beta chain	Homo sapiens	38-48
1716370-0	1991	The peptide Glu-His-Ile-Pro-Ala binds fibrinogen and inhibits platelet aggregation and adhesion to fibrinogen and vitronectin.	Histidine	16-19	fibrinogen beta chain	Homo sapiens	99-109
1716370-4	1991	Unlike peptides related to Arg-Gly-Asp-Ser and His-His-Leu-Gly-Gly-Ala-Lys-Gln-Ala-Gly-Asp-Val that bind to the fibrinogen receptor, this peptide binds to fibrinogen.	Histidine	47-50	fibrinogen beta chain	Homo sapiens	112-122
1716370-4	1991	Unlike peptides related to Arg-Gly-Asp-Ser and His-His-Leu-Gly-Gly-Ala-Lys-Gln-Ala-Gly-Asp-Val that bind to the fibrinogen receptor, this peptide binds to fibrinogen.	Histidine	47-50	fibrinogen beta chain	Homo sapiens	155-165
1716370-4	1991	Unlike peptides related to Arg-Gly-Asp-Ser and His-His-Leu-Gly-Gly-Ala-Lys-Gln-Ala-Gly-Asp-Val that bind to the fibrinogen receptor, this peptide binds to fibrinogen.	Histidine	51-54	fibrinogen beta chain	Homo sapiens	112-122
1716370-4	1991	Unlike peptides related to Arg-Gly-Asp-Ser and His-His-Leu-Gly-Gly-Ala-Lys-Gln-Ala-Gly-Asp-Val that bind to the fibrinogen receptor, this peptide binds to fibrinogen.	Histidine	51-54	fibrinogen beta chain	Homo sapiens	155-165
1654090-5	1991	Electron nuclear double resonance (ENDOR) measurements on the VO(2+)-apoferritin complex showed couplings from two nitrogen nuclei, tentatively ascribed to the N1 and N3 nitrogens of the imidazole ligand of histidine.	Histidine	207-216	ferritin heavy chain	Equus caballus	69-80
1915339-7	1991	The His-Phe-Xaa-Asp-Ala sequence (positions 60-64) is similar to the sequence (His-Phe-Asp-Ala) involving the active-site His119 of bovine pancreatic RNase A, and the Pro-Leu-His sequence (positions 124-126) is identical with the sequence involving the active-site His134 of porcine pancreatic DNase I.	Histidine	4-7	ribonuclease pancreatic	Bos taurus	150-157
1915339-7	1991	The His-Phe-Xaa-Asp-Ala sequence (positions 60-64) is similar to the sequence (His-Phe-Asp-Ala) involving the active-site His119 of bovine pancreatic RNase A, and the Pro-Leu-His sequence (positions 124-126) is identical with the sequence involving the active-site His134 of porcine pancreatic DNase I.	Histidine	79-82	ribonuclease pancreatic	Bos taurus	150-157
1898340-7	1991	This might accompany a change in the configuration around His-48 of the phospholipase A2 subunit.	Histidine	58-61	phospholipase A2 group IB	Homo sapiens	72-88
1653835-8	1991	These results are in accordance with binding data and demonstrate further the importance of residues in positions 9 (Thr) and 10 (His) to ensure potent antagonistic properties of N-truncated hCGRP fragments.	Histidine	130-133	calcitonin related polypeptide alpha	Homo sapiens	191-196
1881903-9	1991	In agreement with earlier predictions, our experimental data demonstrate that His-295, His-299, and Glu-318 constitute the three ligands of the intrinsic zinc atom in LTA4 hydrolase.	Histidine	78-81	leukotriene A4 hydrolase	Mus musculus	167-181
1881903-9	1991	In agreement with earlier predictions, our experimental data demonstrate that His-295, His-299, and Glu-318 constitute the three ligands of the intrinsic zinc atom in LTA4 hydrolase.	Histidine	87-90	leukotriene A4 hydrolase	Mus musculus	167-181
1716913-1	1991	A metal binding peptide, hexahistidine, preceding a renin cleavage sequence (Pro-Phe-His-Leu-Val-Ile-His-) was engineered on to the N-terminus of HIV-1 reverse transcriptase (RT).	Histidine	85-88	renin	Homo sapiens	52-57
1917973-0	1991	A catalytic role for histidine 237 in rat mammary gland thioesterase II.	Histidine	21-30	oleoyl-ACP hydrolase	Rattus norvegicus	56-71
1716370-6	1991	The resulting peptide (Glu-His-Ile-Pro-Ala) has the characteristics of a fibrinogen binding site mimic: It binds fibrinogen and inhibits both the adhesion of platelets to fibrinogen and platelet aggregation.	Histidine	27-30	fibrinogen beta chain	Homo sapiens	73-83
1716370-6	1991	The resulting peptide (Glu-His-Ile-Pro-Ala) has the characteristics of a fibrinogen binding site mimic: It binds fibrinogen and inhibits both the adhesion of platelets to fibrinogen and platelet aggregation.	Histidine	27-30	fibrinogen beta chain	Homo sapiens	113-123
1716370-6	1991	The resulting peptide (Glu-His-Ile-Pro-Ala) has the characteristics of a fibrinogen binding site mimic: It binds fibrinogen and inhibits both the adhesion of platelets to fibrinogen and platelet aggregation.	Histidine	27-30	fibrinogen beta chain	Homo sapiens	113-123
1894611-1	1991	We have recently identified and characterized a chymotrypsin-like serine proteinase in human heart (human heart chymase) that is the most catalytically efficient enzyme described, thus far, for the cleavage of angiotensin I to yield angiotensin II and the dipeptide His-Leu.	Histidine	266-269	angiotensinogen	Homo sapiens	210-223
1894611-1	1991	We have recently identified and characterized a chymotrypsin-like serine proteinase in human heart (human heart chymase) that is the most catalytically efficient enzyme described, thus far, for the cleavage of angiotensin I to yield angiotensin II and the dipeptide His-Leu.	Histidine	266-269	angiotensinogen	Homo sapiens	233-247
1678740-4	1991	Using site-directed mutagenesis of the cDNA encoding the NEP sequence, we have already shown that His residues 583 and 587 are two of the three zinc ligands.	Histidine	98-101	membrane metalloendopeptidase	Homo sapiens	57-60
1714722-2	1991	Results obtained from both peptide mapping and fast atom bombardment mass spectrometry indicate that tyrosine 67 in the sequence -Thr-Thr-His-Tyr67-Gly-Ser-Leu-Pro-Gln-Lys- in bovine MBP is the specific phosphorylation site.	Histidine	138-141	myelin basic protein	Bos taurus	183-186
1768762-1	1991	A congenital fibrinogen variant in a German family is described which has been identified as a substitution of His in position 16 of the A alpha-chain for Arg, manifested over three generations in heterozygous form.	Histidine	111-114	fibrinogen beta chain	Homo sapiens	13-23
1659346-6	1991	Administering T3 produced a marked increase in the brush border ACE activity (from 42.87 +/- 4.9 to 81.41 +/- 11.7 nmol His-Leu/min/mg protein).	Histidine	120-123	angiotensin I converting enzyme	Rattus norvegicus	64-67
1830308-9	1991	Diethyl pyrocarbonate and N-bromosuccinimide, reagents used to modify histidine residues, reversed the increase in affinity of [125I]BOP at pH 6.0 to values equivalent to those at pH 7.4.	Histidine	70-79	BOP	Homo sapiens	133-136
1650827-1	1991	The binding and internalization of a novel adrenocorticotropic hormone (ACTH) analog having a potent neuromodulating effect, ebiratide (H-Met(O2)-Glu-His-Phe-D-Lys-Phe-NH(CH2)8NH2), by isolated bovine brain capillaries, were examined.	Histidine	150-153	proopiomelanocortin	Homo sapiens	72-76
1677358-6	1991	In one out of the five subjects with the apoA-IV-1/0 phenotype we identified two point mutations: 1) replacing the positively charged lysine (AAG), amino acid 167, with a negatively charged glutamic acid (GAG), and 2) converting the neutral residue 360, glutamine (CAG), to a positively charged histidine (CAT).	Histidine	295-304	apolipoprotein A4	Homo sapiens	41-48
1648392-4	1991	Diethyl pyrocarbonate (DEP), a histidine-modifying agent, inhibits CaM-PDE with a second-order rate constant of 130 M-1 min-1 at pH 7.0 and 30 degrees C. Activity is restored by NH2OH.	Histidine	31-40	calmodulin	Bos taurus	67-70
2069953-1	1991	To illuminate the role of histidine-95 in the catalytic reaction mediated by triosephosphate isomerase, 13C and 15N NMR titration studies have been carried out both on the wild-type enzyme and on a mutant isomerase in which the single remaining histidine (that at the active site) has been isotopically enriched in the imidazole ring.	Histidine	26-35	triosephosphate isomerase 1	Homo sapiens	77-102
1854739-4	1991	The KL values were obtained by monitoring the susceptibility to alkylation of His-48 at the catalytic site of pig pancreatic PLA2 bound to micellar dispersions of the neutral diluent 2-hexadecyl-sn-glycero-3-phosphocholine.	Histidine	78-81	phospholipase A2, major isoenzyme	Sus scrofa	125-129
2068075-7	1991	Site-directed mutation of the His-74 residue in HLA-A2 to the Asp-74 (HLA-A3, -Aw68, -Aw69, -B7) residue generates a mutant that provides C1R cell line transfectants an NK-resistant phenotype.	Histidine	30-33	complement C1r	Homo sapiens	138-141
2065039-0	1991	The mutation causing the common apolipoprotein A-IV polymorphism is a glutamine to histidine substitution of amino acid 360.	Histidine	83-92	apolipoprotein A4	Homo sapiens	32-51
1724081-4	1991	Sheep galanin shows great similarity to pig galanin, differing by one amino acid substitution, that being a histidine residue, as in cow and rat galanin, instead of tyrosine at position 26.	Histidine	108-117	galanin	Ovis aries	6-13
2051232-2	1991	At a dose of 5.4 mmol/kg body weight, arginine, cysteine, histidine and the amino acid mixture were equipotent in terms of increasing plasma GIP and insulin concentrations.	Histidine	58-67	gastric inhibitory polypeptide	Mus musculus	141-144
1724081-4	1991	Sheep galanin shows great similarity to pig galanin, differing by one amino acid substitution, that being a histidine residue, as in cow and rat galanin, instead of tyrosine at position 26.	Histidine	108-117	galanin	Ovis aries	44-51
1724081-4	1991	Sheep galanin shows great similarity to pig galanin, differing by one amino acid substitution, that being a histidine residue, as in cow and rat galanin, instead of tyrosine at position 26.	Histidine	108-117	galanin	Ovis aries	44-51
2059622-1	1991	A mutant of the serine protease, subtilisin BPN", in which the catalytic His64 is replaced by Ala (H64A), is very specific for substrates containing a histidine, presumably by the substrate-bound histidine assisting in catalysis [Carter, P., &amp; Wells, J.A.	Histidine	151-160	coagulation factor II, thrombin	Homo sapiens	16-31
2065098-1	1991	Sensitive Raman difference spectroscopy was used to monitor the protonation and deprotonation of histidine residues in apo-transferrin.	Histidine	97-106	transferrin	Homo sapiens	123-134
2065098-6	1991	Using this method, we have measured the Raman difference spectra of human transferrin at different pH values with respect to pH 8.9, titrating its various histidine residues.	Histidine	155-164	transferrin	Homo sapiens	74-85
2059622-1	1991	A mutant of the serine protease, subtilisin BPN", in which the catalytic His64 is replaced by Ala (H64A), is very specific for substrates containing a histidine, presumably by the substrate-bound histidine assisting in catalysis [Carter, P., &amp; Wells, J.A.	Histidine	196-205	coagulation factor II, thrombin	Homo sapiens	16-31
2065098-8	1991	The pH difference spectrum of transferrin obtained is very similar to that of histidine in solution, but with clear differences in the 1200-1400 cm-1 region.	Histidine	78-87	transferrin	Homo sapiens	30-41
1904009-5	1991	Significantly, the bmi-1 gene, which is expressed in diverse normal cells, encodes a Cys/His metal-binding motif (C3HC4) that resembles those in several DNA-binding proteins and defines a new category of zinc finger gene.	Histidine	89-92	Bmi1 polycomb ring finger oncogene	Mus musculus	19-24
2065098-9	1991	A titration curve with pKa of 6.08 +/- 0.01 fit the data of histidine in solution and a value of 6.56 +/- 0.02 was found for the average value of the 12 histidine residues inside transferrin.	Histidine	153-162	transferrin	Homo sapiens	179-190
2066273-8	1991	It is different from DRB1*1501 in codon 30, where it carries histidine instead of tyrosine.	Histidine	61-70	major histocompatibility complex, class II, DR beta 1	Homo sapiens	21-25
2017175-7	1991	Yeast strains bearing a mutation in any one of the genes GCN1 to GCN4 are defective in derepression of amino acid biosynthetic genes in 10 different pathways under conditions of histidine limitation.	Histidine	178-187	Gcn1p	Saccharomyces cerevisiae S288C	57-61
2043649-10	1991	The present findings appear to support the proposition that the receptor conformation of ANG II contains a tripartite interaction of Tyr, His and carboxylate groups which is analogous to that found at the active site of serine proteinases, and that the tyrosinate nucleophile may activate angiotensin receptors.	Histidine	138-141	angiotensinogen	Rattus norvegicus	89-95
1645521-5	1991	Other biotinylated CaM derivatives were prepared with biotinylated tyrosine and/or histidine residues (diazobenzoylbiocytin; DBB-CaM) or nucleophilic sites (photobiotin acetate; photo-CaM).	Histidine	83-92	calmodulin 1	Homo sapiens	19-22
2049386-9	1991	Candidate residues are Glu-15 or Asp-20, close to His-16 on the N-terminal helix of IL-2.	Histidine	50-53	interleukin 2	Homo sapiens	84-88
1902488-0	1991	Paradoxical response of growth hormone to peptide histidine methionine in acromegaly: comparison with the effects of thyrotropin-releasing hormone and vasoactive intestinal peptide.	Histidine	50-59	growth hormone 1	Homo sapiens	24-38
1860379-4	1991	When arterial RBCs were incubated together with various scavengers of free radical (SOD catalase and histidine and mannitol), the production of LPO was less than that of arterial RBC incubation singly (P less than 0.01).	Histidine	101-110	lactoperoxidase	Homo sapiens	144-147
2018798-5	1991	TNF-M1 and TNF-M4 have deletions of His-73 and Gln-102, respectively.	Histidine	36-39	tumor necrosis factor	Homo sapiens	0-3
2018798-5	1991	TNF-M1 and TNF-M4 have deletions of His-73 and Gln-102, respectively.	Histidine	36-39	tumor necrosis factor	Homo sapiens	11-14
2015913-2	1991	Carbethoxylation of a 1:1 molar complex of caldesmon and calmodulin in the presence of Ca2+ resulted in the stoichiometric N-carbethoxylation of His-610 of caldesmon and His-107 of calmodulin.	Histidine	145-148	calmodulin 1	Homo sapiens	57-67
2015913-2	1991	Carbethoxylation of a 1:1 molar complex of caldesmon and calmodulin in the presence of Ca2+ resulted in the stoichiometric N-carbethoxylation of His-610 of caldesmon and His-107 of calmodulin.	Histidine	145-148	calmodulin 1	Homo sapiens	181-191
2015913-2	1991	Carbethoxylation of a 1:1 molar complex of caldesmon and calmodulin in the presence of Ca2+ resulted in the stoichiometric N-carbethoxylation of His-610 of caldesmon and His-107 of calmodulin.	Histidine	170-173	calmodulin 1	Homo sapiens	57-67
2015913-2	1991	Carbethoxylation of a 1:1 molar complex of caldesmon and calmodulin in the presence of Ca2+ resulted in the stoichiometric N-carbethoxylation of His-610 of caldesmon and His-107 of calmodulin.	Histidine	170-173	calmodulin 1	Homo sapiens	181-191
1847591-2	1991	A series of VIP analogues, including pituitary adenylate cyclase-activating polypeptide (PACAP), displaced 125I-VIP binding and activated adenylate cyclase in the same order of relative potency: PACAP-38 greater than helodermin greater than VIP, PACAP-27 greater than PHM (human peptide with NH2-terminal histidine and COOH-terminal methionine amide).	Histidine	305-314	vasoactive intestinal peptide	Homo sapiens	12-15
1828947-13	1991	Histidine thus appears to be essential for the catalytic activity of the sulfatase.	Histidine	0-9	arylsulfatase family member H	Homo sapiens	73-82
1998724-1	1991	Diferric transferrin was modified using aquopentaammine ruthenium(II), a reagent for surface-accessible uncoordinated histidines.	Histidine	118-128	transferrin	Homo sapiens	9-20
1915110-0	1991	Intranasal administration of His-D-Trp-Ala-Trp-D-Phe-LysNH2 (growth hormone releasing peptide) increased plasma growth hormone and insulin-like growth factor-I levels in normal men.	Histidine	29-32	insulin	Homo sapiens	131-138
1998724-7	1991	His-207 and His-242 in the N-terminal lobe of transferrin and His-535 and His-577 in the C-terminal lobe are within this distance, based on information from the lactoferrin crystal structure.	Histidine	0-3	transferrin	Homo sapiens	46-57
1998724-7	1991	His-207 and His-242 in the N-terminal lobe of transferrin and His-535 and His-577 in the C-terminal lobe are within this distance, based on information from the lactoferrin crystal structure.	Histidine	12-15	transferrin	Homo sapiens	46-57
1998724-7	1991	His-207 and His-242 in the N-terminal lobe of transferrin and His-535 and His-577 in the C-terminal lobe are within this distance, based on information from the lactoferrin crystal structure.	Histidine	12-15	transferrin	Homo sapiens	46-57
1998724-7	1991	His-207 and His-242 in the N-terminal lobe of transferrin and His-535 and His-577 in the C-terminal lobe are within this distance, based on information from the lactoferrin crystal structure.	Histidine	12-15	transferrin	Homo sapiens	46-57
1987956-1	1991	Ocular findings are presented from 17 unrelated patients with a form of autosomal dominant retinitis pigmentosa and the same cytosine-to-adenine transversion in codon 23 of the rhodopsin gene corresponding to a substitution of histidine for proline in the 23rd amino acid of rhodopsin (designated rhodopsin, Pro-23-His).	Histidine	227-236	rhodopsin	Homo sapiens	177-186
1812733-0	1991	Substrate analogue renin inhibitors containing replacements of histidine in P2 or isosteres of the amide bond between P3 and P2 sites.	Histidine	63-72	renin	Homo sapiens	19-24
1769204-10	1991	Amino acid sequencing of the first 40 residues of the three prolactin isoforms showed arginine at position 24 and histidine at position 27, for the nonglycosylated form, but no identifiable amino acids were detected at this position for the glycosylated isoforms.	Histidine	114-123	prolactin	Meleagris gallopavo	60-69
1825621-5	1991	A significant reduction in serum prolactin (PRL) levels occurred in rats that were responsive to MPA alone or to MPA plus histidine.	Histidine	122-131	prolactin	Rattus norvegicus	44-47
2016986-3	1991	This ACP activity co-eluted with activity that cleaved histidine from des-Leu angiotensin I to form angiotensin II and activity that cleaved tyrosine from benzyloxycarbonyl-glutamyl-tyrosine (ZGT).	Histidine	55-64	angiotensinogen	Homo sapiens	78-91
1654548-3	1991	The stability constant for the complex formed between Cu(II)IDA-PEG and the cytochrome c His-X3-His site is 5.3 x 10(4) M-1, which corresponds to a chelate effect that contributes 1.5 kcal mol-1 to the binding energy.	Histidine	89-92	thiamine thiazole synthase	Saccharomyces cerevisiae S288C	189-194
1654548-3	1991	The stability constant for the complex formed between Cu(II)IDA-PEG and the cytochrome c His-X3-His site is 5.3 x 10(4) M-1, which corresponds to a chelate effect that contributes 1.5 kcal mol-1 to the binding energy.	Histidine	96-99	thiamine thiazole synthase	Saccharomyces cerevisiae S288C	189-194
2268358-1	1990	The substitution of aspartic acid for the naturally-occurring histidine residue in position B10 in human insulin results in an insulin analogue which displays an in vitro potency 4- to 5-fold greater than the parent compound.	Histidine	62-71	insulin	Homo sapiens	105-112
2268358-1	1990	The substitution of aspartic acid for the naturally-occurring histidine residue in position B10 in human insulin results in an insulin analogue which displays an in vitro potency 4- to 5-fold greater than the parent compound.	Histidine	62-71	insulin	Homo sapiens	127-134
2271687-7	1990	The characteristic absorption spectrum of the Co(II)-substituted protein fully supports the model of a tetrahedral binding site comprised of two Cys and two His ligands.	Histidine	157-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-52
2266553-2	1990	The aspartic proteinase, endothiapepsin (EC 3.4.23.6), was complexed with a highly potent renin inhibitor, H-261 (t-Boc-His-Pro-Phe-His-LeuOHVal-Ile-His), where OH denotes a hydroxyethylene (-(S) CHOH-CH2-) transition-state isostere in the scissile bond surrogate.	Histidine	120-123	renin	Homo sapiens	90-95
2266553-2	1990	The aspartic proteinase, endothiapepsin (EC 3.4.23.6), was complexed with a highly potent renin inhibitor, H-261 (t-Boc-His-Pro-Phe-His-LeuOHVal-Ile-His), where OH denotes a hydroxyethylene (-(S) CHOH-CH2-) transition-state isostere in the scissile bond surrogate.	Histidine	132-135	renin	Homo sapiens	90-95
2268669-2	1990	The homonuclear Hartmann-Hahn spectrum clearly shows all connectivities for the histidine, tyrosine and tryptophan residues that exist in IL-6.	Histidine	80-89	interleukin 6	Homo sapiens	138-142
2101409-5	1990	Sequence analysis of lysyl endopeptidase fragments showed that apo E-Kochi differs from normal apo E3 at residue 145, where an arginine residue is substituted for histidine.	Histidine	163-172	apolipoprotein E	Homo sapiens	63-68
2239971-1	1990	In exon 1 at codon 23 of the rhodopsin gene, a mutation resulting in a proline-to-histidine substitution has previously been observed in approximately 12% of American autosomal dominant retinitis pigmentosa (ADRP) patients.	Histidine	82-91	rhodopsin	Homo sapiens	29-38
1701753-6	1990	Because lipoic acid is covalently bound to the zeta-amino group of the lysine residue of PDC-E2, the mutants were designed to replace the lysine residue in the lipoyl domain with glutamine, a negatively charged amino acid; histidine, a positively charged amino acid; and tyrosine, an aromatic amino acid.	Histidine	223-232	dihydrolipoamide S-acetyltransferase	Homo sapiens	89-95
2241171-0	1990	Site-specific oxidation of angiotensin I by copper(II) and L-ascorbate: conversion of histidine residues to 2-imidazolones.	Histidine	86-95	angiotensinogen	Homo sapiens	27-40
2241171-1	1990	The reaction of a histidine-containing peptide (angiotensin I) with copper (II)/ascorbate under physiological conditions has been studied chemically.	Histidine	18-27	angiotensinogen	Homo sapiens	48-61
2241171-6	1990	In addition, the data of FAB-MS and 1H NMR suggested that the unknown residues (modified histidine) within AGT-1 and AGT-2 should have the 2-imidazolone structure.	Histidine	89-98	alanine--glyoxylate aminotransferase 2	Homo sapiens	117-122
2175370-3	1990	In addition, there is mounting evidence, collected mostly in experiments in vitro, that other enzymes may be able to activate angiotensin I, for example by the stepwise release of the C-terminal His and Leu residues.	Histidine	195-198	angiotensinogen	Homo sapiens	126-139
2226852-6	1990	As calmodulin has only one histidine, the hemes are apparently not bound by the iron atom as in hemoglobin, but are probably loosely associated (Kd = 0.5 microM) in hydrophobic pockets which apparently open when the protein is activated by calcium.	Histidine	27-36	calmodulin 1	Homo sapiens	3-13
2147282-4	1990	Site-directed mutagenesis of the His-53, Asp-77, and Ser-138 residues of NS3 that compose the proposed catalytic triad implicates this domain as a serine protease.	Histidine	33-36	coagulation factor II, thrombin	Homo sapiens	147-162
2120224-2	1990	Histidase (histidine ammonia-lyase, EC 4.3.1.3) catalyzes the deamination of histidine to urocanic acid.	Histidine	11-20	histidine ammonia lyase	Rattus norvegicus	0-9
2121544-1	1990	Purified ADPRT protein was inactivated by the histidine specific reagent diethylpyrocarbonate, binding to two histidine residues, or by a relatively histidine selective photoinactivation method.	Histidine	46-55	poly(ADP-ribose) polymerase 1	Homo sapiens	9-14
2121544-1	1990	Purified ADPRT protein was inactivated by the histidine specific reagent diethylpyrocarbonate, binding to two histidine residues, or by a relatively histidine selective photoinactivation method.	Histidine	110-119	poly(ADP-ribose) polymerase 1	Homo sapiens	9-14
2121544-1	1990	Purified ADPRT protein was inactivated by the histidine specific reagent diethylpyrocarbonate, binding to two histidine residues, or by a relatively histidine selective photoinactivation method.	Histidine	110-119	poly(ADP-ribose) polymerase 1	Homo sapiens	9-14
1707276-2	1990	Analogues of gastrin releasing peptide (GRP) and bombesin based on His-Trp-Ala-Val-D-Ala-His-Leu, the 20-26 heptapeptide sequence of [D-Ala24]GRP, have been synthesized and tested in vitro for their ability to inhibit GRP (18-27)-induced mitogenesis in Swiss 3T3 cells.	Histidine	67-70	gastrin releasing peptide	Mus musculus	13-38
1707276-2	1990	Analogues of gastrin releasing peptide (GRP) and bombesin based on His-Trp-Ala-Val-D-Ala-His-Leu, the 20-26 heptapeptide sequence of [D-Ala24]GRP, have been synthesized and tested in vitro for their ability to inhibit GRP (18-27)-induced mitogenesis in Swiss 3T3 cells.	Histidine	67-70	gastrin releasing peptide	Mus musculus	40-43
2097320-6	1990	Excessive histidine increased liver cytochrome P-450, whereas excessive tyrosine markedly decreased liver cytochrome P-450.	Histidine	10-19	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	36-52
2290835-6	1990	The orientation of histidine residues is usually stabilized through hydrogen bonding; ND1-protonated form of a helical residue can form a hydrogen bond with the carbonyl oxygen atom in the preceding turn of the helix.	Histidine	19-28	mitochondrially encoded NADH dehydrogenase 1	Homo sapiens	86-89
2166134-6	1990	The analysis has shown that the histidine hydrogens involved in metal binding at the enzyme active site are the same in both native and PEG-modified SOD.	Histidine	32-41	superoxide dismutase 1	Homo sapiens	149-152
2167456-9	1990	They are bis-histidine, as in mammalian cytochrome b5, methionine-histidine, typified by cytochrome c and lysine-histidine, recently recognized by spectroscopic methods in cytochrome f. Here we report the electron paramagnetic resonance and near infrared magnetic circular dichroism spectra of the oxidized state of Ps.	Histidine	13-22	cytochrome c, somatic	Homo sapiens	89-101
2167456-9	1990	They are bis-histidine, as in mammalian cytochrome b5, methionine-histidine, typified by cytochrome c and lysine-histidine, recently recognized by spectroscopic methods in cytochrome f. Here we report the electron paramagnetic resonance and near infrared magnetic circular dichroism spectra of the oxidized state of Ps.	Histidine	66-75	cytochrome c, somatic	Homo sapiens	89-101
2173977-2	1990	Various Ty-containing His+ revertants have been isolated and the HIS4/Ty junction region sequenced.	Histidine	22-25	trifunctional histidinol dehydrogenase/phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase	Saccharomyces cerevisiae S288C	65-69
2201466-6	1990	In that gene, a C----A transversion in codon 23, resulting in a proline----histidine substitution has now been identified in 17 of 148 unrelated ADRP patients in the United States (Dryja et al.	Histidine	75-84	perilipin 2	Homo sapiens	145-149
2163026-3	1990	The NOD mouse does not express I-E owing to a deletion in the promoter region of the I-E alpha-chain gene, and the sequence of NOD I-A beta-chain in the first external domain is unique with His 56 and Ser 57 replacing Pro and Asp, respectively, at these positions.	Histidine	190-193	histocompatibility 2, class II antigen A, beta 1	Mus musculus	133-139
2384133-1	1990	The neurotransmitter peptides vasoactive intestinal polypeptide (VIP), peptide histidine isoleucine (PHI) and neuropeptide Y (NPY) are located in nerve fibers supplying the pig choroid plexus, which receives an abundant sympathetic innervation.	Histidine	79-88	neuropeptide Y	Sus scrofa	126-129
2118529-3	1990	In the absence of coordinating anions, the coordination spheres of the Co(II) ions in the proinsulin and insulin R6 hexamers comprise identical pseudotetrahedral arrangements of 3 histidine residues and 1 hydroxide ion.	Histidine	180-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-77
2118529-3	1990	In the absence of coordinating anions, the coordination spheres of the Co(II) ions in the proinsulin and insulin R6 hexamers comprise identical pseudotetrahedral arrangements of 3 histidine residues and 1 hydroxide ion.	Histidine	180-189	insulin	Homo sapiens	90-100
2081598-4	1990	Recent studies have indicated the presence of a point mutation at codon 23 in exon 1 of rhodopsin which results in the substitution of histidine for the highly conserved amino acid proline, suggesting that this mutation is a cause of rhodopsin-linked ADRP.	Histidine	135-144	rhodopsin	Homo sapiens	88-97
2081598-4	1990	Recent studies have indicated the presence of a point mutation at codon 23 in exon 1 of rhodopsin which results in the substitution of histidine for the highly conserved amino acid proline, suggesting that this mutation is a cause of rhodopsin-linked ADRP.	Histidine	135-144	rhodopsin	Homo sapiens	234-243
2081598-4	1990	Recent studies have indicated the presence of a point mutation at codon 23 in exon 1 of rhodopsin which results in the substitution of histidine for the highly conserved amino acid proline, suggesting that this mutation is a cause of rhodopsin-linked ADRP.	Histidine	135-144	perilipin 2	Homo sapiens	251-255
2271531-10	1990	Insulin mutants [B25-Asp]insulin and [B25-His]insulin display 16- and 20-fold decreases in IDE affinity versus wild-type insulin.	Histidine	42-45	insulin	Homo sapiens	0-7
2271531-10	1990	Insulin mutants [B25-Asp]insulin and [B25-His]insulin display 16- and 20-fold decreases in IDE affinity versus wild-type insulin.	Histidine	42-45	insulin	Homo sapiens	46-53
2271531-10	1990	Insulin mutants [B25-Asp]insulin and [B25-His]insulin display 16- and 20-fold decreases in IDE affinity versus wild-type insulin.	Histidine	42-45	insulin	Homo sapiens	46-53
1698454-1	1990	The primary structure of the blood vessel inducing protein angiogenin is 35% identical with that of pancreatic ribonuclease (RNase) and contains counterparts for the critical RNase active-site residues His-12, Lys-41, and His-119.	Histidine	202-205	ribonuclease A family member k6	Gallus gallus	59-69
1698454-1	1990	The primary structure of the blood vessel inducing protein angiogenin is 35% identical with that of pancreatic ribonuclease (RNase) and contains counterparts for the critical RNase active-site residues His-12, Lys-41, and His-119.	Histidine	222-225	ribonuclease A family member k6	Gallus gallus	59-69
1980269-0	1990	Synthesis and 11C-labelling of the ACTH fragment analogue H-Met(O2)-Glu-His-Phe-D-Lys-Phe-OH (Org 2766) via its homocystine-containing precursor.	Histidine	72-75	proopiomelanocortin	Homo sapiens	35-39
2163392-0	1990	Isolation of the Candida albicans histidinol dehydrogenase (HIS4) gene and characterization of a histidine auxotroph.	Histidine	97-106	trifunctional histidinol dehydrogenase/phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase	Saccharomyces cerevisiae S288C	60-64
1972721-7	1990	VLA-5-dependent binding to FN but not costimulation by FN can be specifically blocked with peptides containing the RGD (arg-gly-asp) tripeptide sequence whereas VLA-4-dependent binding and costimulation can both be efficiently inhibited by a 12 amino acid peptide, LHGPEILDVPST (leu-his-gly-pro-glu-iso-leu-asp-val-pro-ser-thr), derived from the alternatively spliced IIICS region of FN.	Histidine	283-286	integrin subunit alpha 5	Homo sapiens	0-5
1972721-7	1990	VLA-5-dependent binding to FN but not costimulation by FN can be specifically blocked with peptides containing the RGD (arg-gly-asp) tripeptide sequence whereas VLA-4-dependent binding and costimulation can both be efficiently inhibited by a 12 amino acid peptide, LHGPEILDVPST (leu-his-gly-pro-glu-iso-leu-asp-val-pro-ser-thr), derived from the alternatively spliced IIICS region of FN.	Histidine	283-286	fibronectin 1	Homo sapiens	27-29
2192846-9	1990	Members of a fourth family with hyperproinsulinemia have a substitution of B10-His with Asp, resulting in a proinsulin that exhibits markedly altered subcellular sorting behavior.	Histidine	79-82	insulin	Homo sapiens	37-47
2194797-10	1990	The deduced amino acid sequence of GAP1 protein presents strong similarities to those of the yeast arginine, histidine and proline permeases, suggesting a common evolutionary origin for these amino acid permeases.	Histidine	109-118	amino acid permease GAP1	Saccharomyces cerevisiae S288C	35-39
2199333-6	1990	The putative CDC43 gene product contains a possible nuclear-localization signal sequence, a cysteine-rich domain and a histidine-rich domain, and a region that is similar in structure to alpha-helix-turn-alpha-helix structural domains present in some prokaryotic and eukaryotic DNA-binding proteins.	Histidine	119-128	protein geranylgeranyltransferase type I subunit CDC43	Saccharomyces cerevisiae S288C	13-18
2341612-1	1990	The purpose of the study was to determine the morphology and distribution of vasoactive intestinal polypeptide- and peptide histidine isoleucine-immunoreactive (VIP- and PHI-ir) neurons and innervation patterns in the main and accessory olfactory bulb, anterior olfactory nucleus, and piriform cortex of the adult cat.	Histidine	124-133	vasoactive intestinal peptide	Homo sapiens	161-164
2341389-0	1990	Histidine 235 of human sex hormone-binding globulin is the covalent site of attachment of the nucleophilic steroid derivative, 17 beta-bromoacetoxydihydrotestosterone.	Histidine	0-9	sex hormone binding globulin	Homo sapiens	23-51
2184838-3	1990	Finally, the results using the above plasma ANGs extend previous studies showing that the substrate specificity of human renin may be influenced by the amino acid residues at P2 (i.e., Ile, Val, or Tyr) and P3 (i.e., His or Tyr) sites.	Histidine	217-220	renin	Homo sapiens	121-126
2349545-1	1990	I: Impaired heparin binding caused by an Arg47 to his (CGT to CAT) substitution.	Histidine	50-53	catalase	Homo sapiens	62-65
2186807-4	1990	Renin pH dependence was evaluated between pH 4.0 and 8.0 by using a synthetic substrate identical with the amino terminus of porcine angiotensinogen (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu*Leu-Val-Tyr-Ser, where the asterisk indicates the scissile peptide bond and the proximal histidine is in italics) and an analogous tetradecapeptide where the proximal histidine was substituted with glutamine.	Histidine	182-185	renin	Homo sapiens	0-5
2378912-5	1990	The data obtained are discussed in terms of the functional role of histidine residues in the cytochrome P-450scc molecule.	Histidine	67-76	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	93-112
2156683-6	1990	We conclude that histidine in the 7 position in the N-terminus of GLP-I-(7-37) is crucial for cAMP formation and insulin secretion, and that removal of the last three C-terminus residues of GLP-I-(7-37) results in only partial loss of activity; the residue in the 34 position is, however, essential for the insulinotropic action.	Histidine	17-26	insulin	Homo sapiens	113-120
2186807-4	1990	Renin pH dependence was evaluated between pH 4.0 and 8.0 by using a synthetic substrate identical with the amino terminus of porcine angiotensinogen (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu*Leu-Val-Tyr-Ser, where the asterisk indicates the scissile peptide bond and the proximal histidine is in italics) and an analogous tetradecapeptide where the proximal histidine was substituted with glutamine.	Histidine	279-288	renin	Homo sapiens	0-5
2186807-1	1990	Steady-state kinetic analysis of human renin demonstrates the histidine proximal to the substrate scissile peptide bond contributes to the unique specificity and pH dependence of this aspartyl protease.	Histidine	62-71	renin	Homo sapiens	39-44
2186807-4	1990	Renin pH dependence was evaluated between pH 4.0 and 8.0 by using a synthetic substrate identical with the amino terminus of porcine angiotensinogen (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu*Leu-Val-Tyr-Ser, where the asterisk indicates the scissile peptide bond and the proximal histidine is in italics) and an analogous tetradecapeptide where the proximal histidine was substituted with glutamine.	Histidine	357-366	renin	Homo sapiens	0-5
2186807-4	1990	Renin pH dependence was evaluated between pH 4.0 and 8.0 by using a synthetic substrate identical with the amino terminus of porcine angiotensinogen (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu*Leu-Val-Tyr-Ser, where the asterisk indicates the scissile peptide bond and the proximal histidine is in italics) and an analogous tetradecapeptide where the proximal histidine was substituted with glutamine.	Histidine	170-173	renin	Homo sapiens	0-5
2186807-5	1990	Comparison of the pH profiles shows the catalytic efficiency (V/Km) and maximal velocity (V) of renin are greater above pH 6.5 with the substrate containing histidine proximal to the scissile peptide bond, but below pH 5.0 these parameters are greater with the glutamine substrate analogue.	Histidine	157-166	renin	Homo sapiens	96-101
2186807-7	1990	Molecular modeling indicates the substrate histidine could hydrogen bond to Asp-226 of the enzyme (renin numbering), thus perturbing the ionization of the catalytic aspartyl groups (Asp-38 and Asp-226).	Histidine	43-52	renin	Homo sapiens	99-104
2368186-7	1990	Such metal-chelating agents as histidine and organic acids increase the SOD activity in gastric juice.	Histidine	31-40	superoxide dismutase 1	Homo sapiens	72-75
2356159-6	1990	Connectivities between the His C alpha proton and the two Pro C delta protons illustrated a preferred conformation for angiotensin II in DMSO in which the His-Pro bond exists as the trans isomer.	Histidine	27-30	angiotensinogen	Homo sapiens	119-133
2155931-0	1990	L-histidine augments the response to 1-deamino-8-D-arginine vasopressin in Brattleboro homozygous (di/di) rats.	Histidine	0-11	arginine vasopressin	Rattus norvegicus	60-71
2155931-1	1990	Studies in vitro have shown that L-histidine increases the hydroosmotic response to vasopressin.	Histidine	33-44	arginine vasopressin	Rattus norvegicus	84-95
2155931-9	1990	In part, histidine may operate by increasing cAMP since the renal cAMP content in response to vasopressin is increased in histidine-fed rats (13.1 +/- 0.9 vs. 9.8 +/- 0.8 nmol/g dry weight, P less than 0.01).	Histidine	9-18	arginine vasopressin	Rattus norvegicus	94-105
2155931-9	1990	In part, histidine may operate by increasing cAMP since the renal cAMP content in response to vasopressin is increased in histidine-fed rats (13.1 +/- 0.9 vs. 9.8 +/- 0.8 nmol/g dry weight, P less than 0.01).	Histidine	122-131	arginine vasopressin	Rattus norvegicus	94-105
1979153-1	1990	GHRP-6 (His-D-Trp-Ala-Trp-D-Phe-LysNH2; SK&amp;F 110679) is a hexapeptide that specifically releases growth hormone.	Histidine	8-11	growth hormone 1	Homo sapiens	101-115
2100004-1	1990	Conformation of the renin inhibitor peptide, Pro-His-Pro-Phe-His-Phe-Phe-Val-Tyr-Lys (RIP) has been studied in aqueous solution and in lipid bilayers using 500 MHz 1H NMR spectroscopy.	Histidine	49-52	renin	Homo sapiens	20-25
2163402-0	1990	A nuclear magnetic resonance study of the cyclic AMP receptor protein (CRP): assignments of the NH protons of histidine and tryptophan residues and the effect of binding of cAMP to CRP.	Histidine	110-119	C-reactive protein	Homo sapiens	42-69
2163402-0	1990	A nuclear magnetic resonance study of the cyclic AMP receptor protein (CRP): assignments of the NH protons of histidine and tryptophan residues and the effect of binding of cAMP to CRP.	Histidine	110-119	C-reactive protein	Homo sapiens	71-74
2144687-4	1990	Sequence similarities with putative heme binding regions of myeloperoxidase and thyroid peroxidase suggest that the sequence TI(L)WLREHNRV of PGG/H synthase contains the histidine (His309) which is the proximal heme ligand; the distal heme ligand may be His226 which is found in the sequence 222-KALGH-226.	Histidine	170-179	myeloperoxidase	Homo sapiens	60-75
34774741-5	2022	Among these JAK1 inhibitors, the compound 23a showed an IC50 level of 72 nM, as well as being selective against other JAKs by 12 times or more: the results of molecular docking studies suggested that the high JAK1 selectivity resulted from a key interaction between the iodine atom of compound 23a and His-885 of hJAK1.	Histidine	302-305	Janus kinase 1	Homo sapiens	118-122
33767335-0	2021	De novo histidine biosynthesis protects Mycobacterium tuberculosis from host IFN-gamma mediated histidine starvation.	Histidine	8-17	interferon gamma	Mus musculus	77-86
33767335-0	2021	De novo histidine biosynthesis protects Mycobacterium tuberculosis from host IFN-gamma mediated histidine starvation.	Histidine	96-105	interferon gamma	Mus musculus	77-86
33796530-0	2021	LHPP-Mediated Histidine Dephosphorylation Suppresses the Self-Renewal of Mouse Embryonic Stem Cells.	Histidine	14-23	phospholysine phosphohistidine inorganic pyrophosphate phosphatase	Mus musculus	0-4
33796530-4	2021	A recent study defined phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP) as a histidine phosphatase, which regulates various biological behaviors in cells via histidine dephosphorylation.	Histidine	44-53	phospholysine phosphohistidine inorganic pyrophosphate phosphatase	Mus musculus	91-95
33796530-7	2021	We found that the histidine phosphorylation level was strikingly reduced following LHPP overexpression.	Histidine	18-27	phospholysine phosphohistidine inorganic pyrophosphate phosphatase	Mus musculus	83-87
33796530-9	2021	Moreover, LHPP-mediated histidine dephosphorylation induced G0/G1 phase arrest in mESCs, suggesting LHPP was implicated in cell proliferation and cell cycle.	Histidine	24-33	phospholysine phosphohistidine inorganic pyrophosphate phosphatase	Mus musculus	10-14
33796530-9	2021	Moreover, LHPP-mediated histidine dephosphorylation induced G0/G1 phase arrest in mESCs, suggesting LHPP was implicated in cell proliferation and cell cycle.	Histidine	24-33	phospholysine phosphohistidine inorganic pyrophosphate phosphatase	Mus musculus	100-104
33796530-12	2021	LHPP-mediated histidine dephosphorylation lowered the expression levels of beta-catenin and the cell cycle-related genes CDK4 and CyclinD1, while it up-regulated the cell cycle suppressor genes P21 and P27.	Histidine	14-23	phospholysine phosphohistidine inorganic pyrophosphate phosphatase	Mus musculus	0-4
33796530-12	2021	LHPP-mediated histidine dephosphorylation lowered the expression levels of beta-catenin and the cell cycle-related genes CDK4 and CyclinD1, while it up-regulated the cell cycle suppressor genes P21 and P27.	Histidine	14-23	cyclin-dependent kinase 4	Mus musculus	121-125
33796530-13	2021	Taken together, our findings reveal that LHPP-mediated histidine dephosphorylation plays a role in the self-renewal of ESCs.	Histidine	55-64	phospholysine phosphohistidine inorganic pyrophosphate phosphatase	Mus musculus	41-45
33796530-14	2021	LHPP-mediated histidine dephosphorylation inhibited the self-renewal of ESCs by negatively regulating the Wnt/beta-catenin pathway and downstream cell cycle-related genes, providing a new perspective and regulatory target for ESCs self-renewal.	Histidine	14-23	phospholysine phosphohistidine inorganic pyrophosphate phosphatase	Mus musculus	0-4
34774741-5	2022	Among these JAK1 inhibitors, the compound 23a showed an IC50 level of 72 nM, as well as being selective against other JAKs by 12 times or more: the results of molecular docking studies suggested that the high JAK1 selectivity resulted from a key interaction between the iodine atom of compound 23a and His-885 of hJAK1.	Histidine	302-305	Janus kinase 1	Homo sapiens	12-16
33973677-7	2021	In silico prediction revealed that HLA-DRB1 alleles with histidine at amino acid position 13 (His13) had significantly weaker binding affinity to an alpha-synuclein epitope than other alleles (P = 9.6 x 10-4 ).	Histidine	57-66	major histocompatibility complex, class II, DR beta 1	Homo sapiens	35-43
18278872-4	2008	The heme in CBS is unusual; it is six-coordinate, low spin, and contains cysteine and histidine as axial ligands.	Histidine	86-95	cystathionine beta-synthase	Homo sapiens	12-15
9146888-13	1997	It was found that photolysis of rose bengal from a 1:2:2:1 quartet, characteristic of the hydroxyl radical-DMPO spin adduct, which was effectively blunted by DMTU, superoxide dismutase and catalase whereas histidine was ineffective.	Histidine	206-215	catalase	Oryctolagus cuniculus	189-197
34688060-1	2022	A water-soluble, stable, simple and dual ligands (bovine serum albumin and L-histidine)-enhanced copper nanoclusters (BSA-CuNCs@L-His) was synthesized by one-step wet chemical method.	Histidine	130-133	albumin	Homo sapiens	57-70
34774692-1	2022	The formimidoyltransferase cyclodeaminase (FTCD) gene encodes an enzyme required for the catabolism of histidine and tetrahydrofolate (THF).	Histidine	103-112	formimidoyltransferase cyclodeaminase	Homo sapiens	4-41
34774692-1	2022	The formimidoyltransferase cyclodeaminase (FTCD) gene encodes an enzyme required for the catabolism of histidine and tetrahydrofolate (THF).	Histidine	103-112	formimidoyltransferase cyclodeaminase	Homo sapiens	43-47
34774741-5	2022	Among these JAK1 inhibitors, the compound 23a showed an IC50 level of 72 nM, as well as being selective against other JAKs by 12 times or more: the results of molecular docking studies suggested that the high JAK1 selectivity resulted from a key interaction between the iodine atom of compound 23a and His-885 of hJAK1.	Histidine	302-305	Janus kinase 1	Homo sapiens	209-213
34774741-5	2022	Among these JAK1 inhibitors, the compound 23a showed an IC50 level of 72 nM, as well as being selective against other JAKs by 12 times or more: the results of molecular docking studies suggested that the high JAK1 selectivity resulted from a key interaction between the iodine atom of compound 23a and His-885 of hJAK1.	Histidine	302-305	Janus kinase 1	Homo sapiens	313-318
34878265-3	2021	In this work, we found that a N-truncated Abeta analogue bearing a His-2 motif, Abeta5-9, forms a stable Ni(II) high-spin octahedral complex at a physiological pH of 7.4 with labile coordination sites and facilitates ternary interactions with phosphates and nucleotides.	Histidine	67-70	amyloid beta precursor protein	Homo sapiens	42-47
34947531-6	2021	The successful immobilization of histidine-tagged HER2 (His-tagged HER2) on NTA via cobalt (II) chelates was demonstrated, confirming the fully functional attachment of the proteins to the AuNP surface.	Histidine	33-42	erb-b2 receptor tyrosine kinase 2	Homo sapiens	50-54
34687221-7	2021	This affinity microfluidic chip has pre-fractioned four human plasma proteins (fibrinogen, immunoglobulin, transferrin and human serum albumin) based on their surface exposed histidine surface topography.	Histidine	175-184	transferrin	Homo sapiens	107-118
34687221-7	2021	This affinity microfluidic chip has pre-fractioned four human plasma proteins (fibrinogen, immunoglobulin, transferrin and human serum albumin) based on their surface exposed histidine surface topography.	Histidine	175-184	albumin	Homo sapiens	129-142
34605082-7	2021	Interestingly, our results suggest a key role of a highly conserved histidine residue among SH2 family in the interaction with negative charges carried by the phosphotyrosine of Gab2.	Histidine	68-77	GRB2 associated binding protein 2	Homo sapiens	178-182
34947531-6	2021	The successful immobilization of histidine-tagged HER2 (His-tagged HER2) on NTA via cobalt (II) chelates was demonstrated, confirming the fully functional attachment of the proteins to the AuNP surface.	Histidine	33-42	erb-b2 receptor tyrosine kinase 2	Homo sapiens	67-71
34947531-6	2021	The successful immobilization of histidine-tagged HER2 (His-tagged HER2) on NTA via cobalt (II) chelates was demonstrated, confirming the fully functional attachment of the proteins to the AuNP surface.	Histidine	56-59	erb-b2 receptor tyrosine kinase 2	Homo sapiens	50-54
34947531-6	2021	The successful immobilization of histidine-tagged HER2 (His-tagged HER2) on NTA via cobalt (II) chelates was demonstrated, confirming the fully functional attachment of the proteins to the AuNP surface.	Histidine	56-59	erb-b2 receptor tyrosine kinase 2	Homo sapiens	67-71
34735131-12	2021	The implementation of selective enrichment of histidine-containing peptides in the workflow was a key that enabled identifying the MAPK14-inhibitor interaction.	Histidine	46-55	mitogen-activated protein kinase 14	Homo sapiens	131-137
34694165-6	2021	These two hits showed good interactions with crucial amino acid residues of Mpro HIS-41 and CYS-145, excellent ADME properties, fair DeltaGbind values (> -188.03 kj/mol), and average protein-ligand complex RMSD < apo-protein RMSD.	Histidine	81-84	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	76-80
34867955-8	2021	Importantly, the noninvasive serum tRF-His-GTG-1 could also be used to distinguish SLE with LN or SLE without LN with AUC of 0.81 (95% CI, 0.73-0.88) and performance (sensitivity 66.27%, specificity 96.15%).	Histidine	39-42	telomeric repeat binding factor 1	Homo sapiens	35-38
34529977-1	2021	X-Ray crystallography shows that the hydroxyl group of Thr-45 in the fermentative alcohol dehydrogenase (ADH1) from Saccharomyces cerevisiae is hydrogen-bonded to the hydroxyl group of the alcohol bound to the catalytic zinc and is part of a proton relay system linked to His-48.	Histidine	272-275	alcohol dehydrogenase ADH1	Saccharomyces cerevisiae S288C	105-109
34425475-5	2021	Heating Rh2(AcO)4 -histidine solutions to 40  C (near body temperature) or 95  C accelerated the formation of RhII2(AcO)2(His)2 and RhIII(His)2(AcO) complexes.	Histidine	122-125	aconitase 2	Homo sapiens	110-121
34737343-6	2021	Binding of a single Zn(II) ion to the PrPC N-terminal domain via four His residues from the octarepeat region induces a structural transition in the C-terminal alpha-helices 2 and 3, promotes interaction between the N-terminal and C-terminal domains, reduces the folded protein size, and modifies the internal structural dynamics.	Histidine	70-73	prion protein	Homo sapiens	38-42
34293440-3	2021	The repeat region of Pmel17 (RPT, residues 315-444) has been previously shown to form amyloid aggregates under acidic melanosomal conditions, but not under neutral cytosolic conditions, when expressed and purified using a C-terminal hexa-histidine tag (RPT-His).	Histidine	257-260	premelanosome protein	Homo sapiens	21-27
34627325-17	2021	Molecular docking study further supported that p-hydroxybenzoic acid, cedar acid, shikimic acid, salicylic acid, nicotinic acid, linalool, and histidine can be well binding with NOS3, SRC, PI3K, and AKT.	Histidine	143-152	AKT serine/threonine kinase 1	Rattus norvegicus	199-202
34241577-1	2021	The eukaryotic tRNA guanine transglycosylase (TGT) is an RNA modifying enzyme incorporating queuine, a hypermodified guanine derivative, into the tRNAsAsp,Asn,His,Tyr.	Histidine	159-162	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	15-44
34241577-1	2021	The eukaryotic tRNA guanine transglycosylase (TGT) is an RNA modifying enzyme incorporating queuine, a hypermodified guanine derivative, into the tRNAsAsp,Asn,His,Tyr.	Histidine	159-162	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	46-49
34626468-4	2021	This also requires the presence of the C-terminal Cys/His-rich domain (CHRD), its binding to the secreted cytosolic cyclase associated protein 1 (CAP-1), and possibly another membrane-bound "protein X".	Histidine	54-57	CAP, adenylate cyclase-associated protein 1 (yeast)	Mus musculus	116-144
34626468-4	2021	This also requires the presence of the C-terminal Cys/His-rich domain (CHRD), its binding to the secreted cytosolic cyclase associated protein 1 (CAP-1), and possibly another membrane-bound "protein X".	Histidine	54-57	CAP, adenylate cyclase-associated protein 1 (yeast)	Mus musculus	146-151
34371051-1	2021	One of the hallmarks of Alzheimer"s Disease (AD) is the anomalous binding involving amyloid-beta (Abeta) peptide and metal ions, such as copper, formed through histidine (His) residues.	Histidine	160-169	amyloid beta precursor protein	Homo sapiens	84-96
34506130-4	2021	While the EV68 3C protease-rupintrivir structure was similar to previously determined complexes with other picornavirus 3C proteases, rupintrivir bound in a unique conformation to the active site of SARS-CoV-2 Mpro splitting the catalytic cysteine and histidine residues.	Histidine	252-261	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	210-214
34605855-4	2022	The gene encodes SNAT3, a sodium-coupled neutral amino acid transporter and a principal transporter of the amino acids asparagine, histidine, and glutamine, the latter being the precursor for the neurotransmitters GABA and glutamate.	Histidine	131-140	solute carrier family 38 member 3	Homo sapiens	17-22
34371051-1	2021	One of the hallmarks of Alzheimer"s Disease (AD) is the anomalous binding involving amyloid-beta (Abeta) peptide and metal ions, such as copper, formed through histidine (His) residues.	Histidine	160-169	amyloid beta precursor protein	Homo sapiens	98-103
34371051-1	2021	One of the hallmarks of Alzheimer"s Disease (AD) is the anomalous binding involving amyloid-beta (Abeta) peptide and metal ions, such as copper, formed through histidine (His) residues.	Histidine	171-174	amyloid beta precursor protein	Homo sapiens	84-96
34371051-1	2021	One of the hallmarks of Alzheimer"s Disease (AD) is the anomalous binding involving amyloid-beta (Abeta) peptide and metal ions, such as copper, formed through histidine (His) residues.	Histidine	171-174	amyloid beta precursor protein	Homo sapiens	98-103
34573562-8	2021	Functional enrichment analysis identified pathways affected by dietary supplementation, including the insulin signaling pathway (beta-alanine supplementation) and the insulin resistance and adipocytokine signaling pathways (L-histidine supplementation).	Histidine	224-235	insulin	Gallus gallus	167-174
34410849-7	2021	Interestingly, both HI and MI upregulated gene sets involved in inflammation (IL6-JAK-STAT3 signaling, allograft rejection, TNFA signaling via NFKB, and inflammatory response; FDR q-value<0.25).	Histidine	20-22	interleukin 6	Homo sapiens	78-81
34410849-7	2021	Interestingly, both HI and MI upregulated gene sets involved in inflammation (IL6-JAK-STAT3 signaling, allograft rejection, TNFA signaling via NFKB, and inflammatory response; FDR q-value<0.25).	Histidine	20-22	signal transducer and activator of transcription 3	Homo sapiens	86-91
34410849-7	2021	Interestingly, both HI and MI upregulated gene sets involved in inflammation (IL6-JAK-STAT3 signaling, allograft rejection, TNFA signaling via NFKB, and inflammatory response; FDR q-value<0.25).	Histidine	20-22	tumor necrosis factor	Homo sapiens	124-128
34340028-7	2021	The second is crosslinker co-immunoprecipitation with an N-terminally His-tagged Prdx2.	Histidine	70-73	peroxiredoxin 2	Homo sapiens	81-86
34343891-12	2021	The molecular docking and MD simulation results revealed that the active site residue Glu-538 of bacterial NEP along with Zn2+ interact with His-13 of Abeta peptide.	Histidine	141-144	membrane metalloendopeptidase	Homo sapiens	107-110
34343891-12	2021	The molecular docking and MD simulation results revealed that the active site residue Glu-538 of bacterial NEP along with Zn2+ interact with His-13 of Abeta peptide.	Histidine	141-144	amyloid beta precursor protein	Homo sapiens	151-156
34233161-7	2021	Acidosis-triggered activation of SLAH3 is mediated by protonation of histidine 330 and 454.	Histidine	69-78	SLAC1 homologue 3	Arabidopsis thaliana	33-38
34458058-9	2021	Thus, this study presents first report that Histidine tag (His6BP) fusion OYDV-CP based antibody production and its successful application in identification of virus free onion and garlic genotypes.	Histidine	44-53	golgi phosphoprotein 3	Homo sapiens	79-81
34225168-3	2021	The model system of hCA VII included the core catalytic center, the Zn2+ ion, its three histidine ligands and a hydroxide ion or water molecule coordinated to it.	Histidine	88-97	carbonic anhydrase 7	Homo sapiens	20-27
34338250-1	2021	The kinetics of electron transfer (ET) from tyrosine (Tyr) to short-lived histidine (His) radicals in peptides of different structures was monitored using time-resolved chemically induced dynamic nuclear polarization (CIDNP) to follow the reduction of the His radicals using NMR detection of the diamagnetic hyperpolarized reaction products.	Histidine	74-83	major facilitator superfamily domain containing 11	Homo sapiens	35-37
34338250-1	2021	The kinetics of electron transfer (ET) from tyrosine (Tyr) to short-lived histidine (His) radicals in peptides of different structures was monitored using time-resolved chemically induced dynamic nuclear polarization (CIDNP) to follow the reduction of the His radicals using NMR detection of the diamagnetic hyperpolarized reaction products.	Histidine	85-88	major facilitator superfamily domain containing 11	Homo sapiens	35-37
34338250-5	2021	Interpretation of the obtained pH dependencies made is possible to quantify the degree of paramagnetic shift of the acidity constant of the imidazole of the His residue in the peptides with a Tyr residue in its paramagnetic state, and to correlate this degree with the intramolecular ET rate constant - a higher intramolecular ET rate constant corresponded to a greater acidity constant shift.	Histidine	157-160	major facilitator superfamily domain containing 11	Homo sapiens	284-286
34338250-5	2021	Interpretation of the obtained pH dependencies made is possible to quantify the degree of paramagnetic shift of the acidity constant of the imidazole of the His residue in the peptides with a Tyr residue in its paramagnetic state, and to correlate this degree with the intramolecular ET rate constant - a higher intramolecular ET rate constant corresponded to a greater acidity constant shift.	Histidine	157-160	major facilitator superfamily domain containing 11	Homo sapiens	327-329
34447559-8	2021	In agreement with these results, careful mapping of all hydrolyzed Asp-X bonds on the protein structure revealed that the lower reactivity toward the alpha-chain was consistent with the presence of more redox-active amino acids (Tyr and His) in this subunit in comparison with the beta-chain.	Histidine	237-240	Fc gamma receptor and transporter	Homo sapiens	150-161
34152722-3	2021	The redesigned interface of Protein G/human IgG Fc domain (referred to as PrG/hIgG), when incorporated with histidine and glutamic acid on PrG (PrG-EHHE), showed a switch in binding affinity by 50-fold when the pH was altered from mild acidic to mild basic.	Histidine	108-117	serglycin	Homo sapiens	74-77
34152722-3	2021	The redesigned interface of Protein G/human IgG Fc domain (referred to as PrG/hIgG), when incorporated with histidine and glutamic acid on PrG (PrG-EHHE), showed a switch in binding affinity by 50-fold when the pH was altered from mild acidic to mild basic.	Histidine	108-117	serglycin	Homo sapiens	144-147
34281489-4	2021	The docking results showed that Leucoefdin interacted with the MPro by forming hydrogen bonds, at Leu 141, His163, His 164, and Glu 166.	Histidine	115-118	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	63-67
34165173-7	2021	Silencing of RASA1 protected against HI/R-induced H9C2 cell injury.	Histidine	37-39	RAS p21 protein activator 1	Rattus norvegicus	13-18
34233759-6	2021	RESULTS: Thirteen metabolites were identified as common biomarkers discriminating ob/ob mice and lepb-/- zebrafish larvae from their respective wild type controls: alanine, citrulline, ethanolamine, glutamine, glycine, histidine, isoleucine, leucine, methionine, phenylalanine, putrescine, serine and threonine.	Histidine	219-228	leptin b	Danio rerio	97-101
34214348-8	2021	The ERbeta agonist was a compound that has parameters similar to 17beta-estradiol in its interaction with 3OLS protein, which has a pharmacophore distance of 10.862 A, and binding to amino acids His 475 and Glu 305 or Arg 346 at receptor-ligand docking simulation.	Histidine	195-198	Era like 12S mitochondrial rRNA chaperone 1	Homo sapiens	4-10
34356603-1	2021	Angiotensin II (Ang II) may contain a charge relay system (CRS) involving Tyr/His/carboxylate, which creates a tyrosinate anion for receptor activation.	Histidine	78-81	angiotensinogen	Homo sapiens	0-23
34277562-1	2021	Herein, selenium and nitrogen co-doped carbon quantum dots (Se/N-CQDs) were hydrothermally synthesized by using citric acid, histidine, and sodium selenite, which had sp3 and sp2 hybridized carbon atoms and showed excitation-dependent fluorescence behavior.	Histidine	125-134	Sp3 transcription factor	Homo sapiens	167-170
34277562-1	2021	Herein, selenium and nitrogen co-doped carbon quantum dots (Se/N-CQDs) were hydrothermally synthesized by using citric acid, histidine, and sodium selenite, which had sp3 and sp2 hybridized carbon atoms and showed excitation-dependent fluorescence behavior.	Histidine	125-134	Sp2 transcription factor	Homo sapiens	175-178
34069937-0	2021	Effects of L-Histidine and Sodium Acetate on beta-Casein Expression in Nutrient-Restricted Bovine Mammary Epithelial Cells.	Histidine	11-22	casein beta	Bos taurus	45-56
34117217-6	2021	Our data suggest that TRAF2 binds to PVQE motif residing in between the PEST and histidine repeat domain (HRD) of DYRK1A protein, and mediates K63-linked ubiquitination of DYRK1A.	Histidine	81-90	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	114-120
34070918-0	2021	Restoring the Oxidase-Like Activity of His@AuNCs for the Determination of Alkaline Phosphatase.	Histidine	39-42	alkaline phosphatase, placental	Homo sapiens	74-94
34070918-3	2021	We found that the pyrophosphate ion (P2O74-, PPi) could effectively inhibit the oxidase mimic activity of His@AuNCs/GO, and the hydrolysis of PPi by ALP restored the inhibited activity of His@AuNCs/GO, enabling them to efficiently catalyze the oxidation of 3,3",5,5"-tetramethylbenzidine (TMB) to generate the blue oxidized product oxTMB.	Histidine	188-191	alkaline phosphatase, placental	Homo sapiens	149-152
34122448-6	2021	The immunodominance of B-cell epitopes, total IgG titers and the levels of IFN-gamma and IL-17A from mice immunized with HI plus different adjuvants were different from each other, which may explain the difference in protective immunity observed in each immunized group.	Histidine	121-123	interferon gamma	Mus musculus	75-84
34069937-6	2021	The relative expression of beta-casein was significantly increased in the NR condition with the inclusion of 0.15 mM His alone or with Ace compared to that in control.	Histidine	117-120	casein beta	Bos taurus	27-38
34069937-9	2021	The results suggest that His has the potential to increase the beta-casein expression under the NR condition.	Histidine	25-28	casein beta	Bos taurus	63-74
35487360-11	2022	The metal ions with weak hydrolysis constants and strong polarization forces could readily interact with N-containing histidine and S-containing cysteine of p53 DBD, which resulted in high Ka values.	Histidine	118-127	tumor protein p53	Homo sapiens	157-160
34063665-5	2021	Significantly greater increases in PEC MT (p < 0.001) and TR MT (p < 0.001) were detected following HV compared to HI.	Histidine	115-117	tRNA mitochondrial 2-thiouridylase	Homo sapiens	58-63
34163842-6	2021	Both Ru1 and Ru2 contain an extended planar imidazo(4,5-f)(1,10)phenanthroline ligand, as compared to a 2,2"-bipyridine ligand for Ru3, and we show that the presence of the phenanthroline ligand promotes covalent binding to Abeta peptide His residues, and in addition, leads to a pronounced effect on peptide aggregation immediately after photoactivation.	Histidine	238-241	amyloid beta precursor protein	Homo sapiens	224-229
35598422-5	2022	The studies on the interaction with two proteins, lysozyme (Lyz) chosen as a representative model of a small protein, and human serum albumin (HSA) show that two types of binding are possible: a non-covalent binding through the accessible residues on protein surface with (VIVO(L1-3)(LNN)) keeping its octahedral structure, and a covalent binding upon the replacement of water in (VIVO(L1-3)(H2O)) with His-N donors to form VIVO(L1-3)(HSA).	Histidine	403-406	lysozyme	Homo sapiens	50-58
35598422-5	2022	The studies on the interaction with two proteins, lysozyme (Lyz) chosen as a representative model of a small protein, and human serum albumin (HSA) show that two types of binding are possible: a non-covalent binding through the accessible residues on protein surface with (VIVO(L1-3)(LNN)) keeping its octahedral structure, and a covalent binding upon the replacement of water in (VIVO(L1-3)(H2O)) with His-N donors to form VIVO(L1-3)(HSA).	Histidine	403-406	lysozyme	Homo sapiens	60-63
35598422-5	2022	The studies on the interaction with two proteins, lysozyme (Lyz) chosen as a representative model of a small protein, and human serum albumin (HSA) show that two types of binding are possible: a non-covalent binding through the accessible residues on protein surface with (VIVO(L1-3)(LNN)) keeping its octahedral structure, and a covalent binding upon the replacement of water in (VIVO(L1-3)(H2O)) with His-N donors to form VIVO(L1-3)(HSA).	Histidine	403-406	albumin	Homo sapiens	128-141
35346814-3	2022	Drosophila melanogaster can discriminate histidine and histamine using GR22e and IR76b in bitter-sensing gustatory receptor neurons (GRNs).	Histidine	41-50	Gustatory receptor 22e	Drosophila melanogaster	71-76
35614088-4	2022	High-density-lipoprotein cholesterol and apolipoprotein-A1 were associated inversely with BMI and ABSI but positively with HI.	Histidine	123-125	apolipoprotein A1	Homo sapiens	41-58
35631316-0	2022	Exposure to the Amino Acids Histidine, Lysine, and Threonine Reduces mTOR Activity and Affects Neurodevelopment in a Human Cerebral Organoid Model.	Histidine	28-37	mechanistic target of rapamycin kinase	Homo sapiens	69-73
35631316-2	2022	Previous in vitro and in vivo results show that three specific amino acids, histidine, lysine, and threonine, synergistically inhibit mTOR activity and behavior.	Histidine	76-85	mechanistic target of rapamycin kinase	Homo sapiens	134-138
35631316-8	2022	Exposure to threonine, histidine, and lysine led to decreased mTOR activity and markedly reduced organoid size, supporting findings in rodent studies.	Histidine	23-32	mechanistic target of rapamycin kinase	Homo sapiens	62-66
35631316-11	2022	Threonine, histidine, and lysine exposure impacts the early development of human cerebral organoids, illustrated by the inhibition of mTOR activity, reduced size, and altered gene expression.	Histidine	11-20	mechanistic target of rapamycin kinase	Homo sapiens	134-138
35390165-0	2022	A histidine cluster determines YY1-compartmentalized coactivators and chromatin elements in phase-separated enhancer clusters.	Histidine	2-11	YY1 transcription factor	Homo sapiens	31-34
35390165-3	2022	Here, we demonstrate that a histidine cluster in YY1"s transactivation domain is essential for its formation of phase separation condensates, which can be extended to additional proteins.	Histidine	28-37	YY1 transcription factor	Homo sapiens	49-52
35390165-4	2022	The histidine cluster is also required for YY1-promoted cell proliferation, migration, clonogenicity and tumor growth.	Histidine	4-13	YY1 transcription factor	Homo sapiens	43-46
35390165-9	2022	Overall, this study demonstrates that YY1 activates target gene expression through forming liquid-liquid phase separation condensates to compartmentalize both coactivators and enhancer elements, and the histidine cluster of YY1 plays a determinant role in this regulatory mechanism.	Histidine	203-212	YY1 transcription factor	Homo sapiens	38-41
35390165-9	2022	Overall, this study demonstrates that YY1 activates target gene expression through forming liquid-liquid phase separation condensates to compartmentalize both coactivators and enhancer elements, and the histidine cluster of YY1 plays a determinant role in this regulatory mechanism.	Histidine	203-212	YY1 transcription factor	Homo sapiens	224-227
35588869-5	2022	In the free state, USP34 adopts an inactive conformation, which contains a misaligned catalytic histidine in the triad.	Histidine	96-105	ubiquitin specific peptidase 34	Homo sapiens	19-24
35346814-3	2022	Drosophila melanogaster can discriminate histidine and histamine using GR22e and IR76b in bitter-sensing gustatory receptor neurons (GRNs).	Histidine	41-50	Ionotropic receptor 76b	Drosophila melanogaster	81-86
35481627-8	2022	Substituting the arginine in Physaleae POS1-like by histidine completely abolished their function in the fruits and the protein-protein interaction (PPI) with calreticulin-3.	Histidine	52-61	calreticulin 3	Homo sapiens	159-173
35408828-12	2022	The observed histidine conformation is part of a mechanism for SPINK1 that can explain the exceptional proteolytic stability of this inhibitor.	Histidine	13-22	serine peptidase inhibitor Kazal type 1	Homo sapiens	63-69
35393539-4	2022	After sensing damage, the activated PARP1 binds to transcriptionally engaged P-TEFb and modifies CycT1 at multiple positions, including histidine residues that are rarely used as an acceptor site.	Histidine	136-145	poly(ADP-ribose) polymerase 1	Homo sapiens	36-41
35393539-4	2022	After sensing damage, the activated PARP1 binds to transcriptionally engaged P-TEFb and modifies CycT1 at multiple positions, including histidine residues that are rarely used as an acceptor site.	Histidine	136-145	cyclin T1	Homo sapiens	97-102
35630298-5	2022	Western blot coupled with anti-His tag confirmed overexpression of the ari1 gene.	Histidine	31-34	carbonyl reductase (NADPH-dependent) ARI1	Saccharomyces cerevisiae S288C	71-75
35379233-10	2022	Protein structure analysis also revealed that the variant probably leads to the deletion of DHH (Asp-His-His) domain, the active site of the protein, and loss of PRUNE1 function.	Histidine	105-108	desert hedgehog signaling molecule	Homo sapiens	92-95
35346558-9	2022	Laser scanning confocal microscopy showed that the signals from cells transfected with the pcDNA3.1/V5-His-730insG-LORICRIN vector were distributed mainly in the nucleus, whereas those from cells transfected with the pcDNA3.1/V5-His-c.323G>C-LORICRIN vector were mainly located in the cytoplasm.	Histidine	103-106	loricrin cornified envelope precursor protein	Homo sapiens	115-123
35346558-9	2022	Laser scanning confocal microscopy showed that the signals from cells transfected with the pcDNA3.1/V5-His-730insG-LORICRIN vector were distributed mainly in the nucleus, whereas those from cells transfected with the pcDNA3.1/V5-His-c.323G>C-LORICRIN vector were mainly located in the cytoplasm.	Histidine	103-106	loricrin cornified envelope precursor protein	Homo sapiens	242-250
35346558-9	2022	Laser scanning confocal microscopy showed that the signals from cells transfected with the pcDNA3.1/V5-His-730insG-LORICRIN vector were distributed mainly in the nucleus, whereas those from cells transfected with the pcDNA3.1/V5-His-c.323G>C-LORICRIN vector were mainly located in the cytoplasm.	Histidine	229-232	loricrin cornified envelope precursor protein	Homo sapiens	115-123
35346558-9	2022	Laser scanning confocal microscopy showed that the signals from cells transfected with the pcDNA3.1/V5-His-730insG-LORICRIN vector were distributed mainly in the nucleus, whereas those from cells transfected with the pcDNA3.1/V5-His-c.323G>C-LORICRIN vector were mainly located in the cytoplasm.	Histidine	229-232	loricrin cornified envelope precursor protein	Homo sapiens	242-250
35339000-4	2022	The activated caspase-3 and changes of ATPase activity in UMH-treated meat accelerated the postmortem ageing, and L-histidine might competitively inhibit the actin-myosin binding by the imidazole group.	Histidine	114-125	caspase 3	Homo sapiens	14-23
35216047-0	2022	Mechanistic Insights into the Polymorphic Associations and Cross-Seeding of Abeta and hIAPP in the Presence of Histidine Tautomerism: An All-Atom Molecular Dynamic Study.	Histidine	111-120	amyloid beta precursor protein	Homo sapiens	76-81
35269675-3	2022	To probe the importance of R369, we introduced a histidine mutation of that residue into Drosophila myosin and implemented an integrative approach to determine effects at the biochemical, cellular, and whole organism levels.	Histidine	49-58	Myosin heavy chain	Drosophila melanogaster	100-106
35269675-4	2022	Substituting the similarly charged but bulkier histidine residue reduces maximal actin binding in vitro without affecting myosin ATPase activity.	Histidine	47-56	Actin 79B	Drosophila melanogaster	81-86
2556391-2	1989	Variant forms of mammalian gonadotropin-releasing hormone (GnRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly.NH2) are present in chicken ([Gln8] GnRH and [His5, Trp7, Tyr8]GnRH), salmon ([Trp7, Leu8]GnRH), and lamprey ([Tyr3, Leu5, Glu6, Trp7, Lys8] GnRH).	Histidine	71-74	gonadotropin releasing hormone 1	Homo sapiens	27-57
35051069-0	2022	Detection of Benzo(a)pyrene Diol Epoxide Adducts to Histidine and Lysine in Serum Albumin In Vivo by High-Resolution-Tandem Mass Spectrometry.	Histidine	52-61	albumin	Homo sapiens	82-89
35051069-2	2022	The exposure of humans to this PAH can be assessed by measuring stable blood protein adducts, such as to histidine and lysine in serum albumin, from their reactive metabolites.	Histidine	105-114	albumin	Homo sapiens	135-142
35051069-10	2022	The achieved method detection limit for the (+)-anti-benzo(a)pyrene diol epoxide adduct to histidine was approximately 4 amol/mg serum albumin.	Histidine	91-100	albumin	Homo sapiens	135-142
35051069-13	2022	In human serum albumin, the anti-benzo(a)pyrene diol epoxide adducts to histidine were detected in only two out of twelve samples and at a level of approximately 0.1 fmol/mg.	Histidine	72-81	albumin	Homo sapiens	9-22
2584190-2	1989	The histidine residues in human chorionic gonadotropin (hCG) were chemically modified using diethyl pyrocarbonate.	Histidine	4-13	chorionic gonadotropin subunit beta 5	Homo sapiens	56-59
2584190-3	1989	Derivatives of hCG with an average of 0.5-3.5 histidines modified (maximum of 4 per hCG) had reduced receptor-binding and cell-stimulating activities.	Histidine	46-56	chorionic gonadotropin subunit beta 5	Homo sapiens	15-18
2584190-3	1989	Derivatives of hCG with an average of 0.5-3.5 histidines modified (maximum of 4 per hCG) had reduced receptor-binding and cell-stimulating activities.	Histidine	46-56	chorionic gonadotropin subunit beta 5	Homo sapiens	84-87
35163075-3	2022	Here, we propose a multi-step approach for the expression and purification of homodimeric, fully active, histidine-tagged recombinant gremlin-1, using mammalian HEK293T cells.	Histidine	105-114	gremlin 1, DAN family BMP antagonist	Homo sapiens	134-143
2557894-2	1989	A different residue, which is most likely lysine, is the sixth heme ligand in oxidized spinach cytochrome f. The data for oxidized yeast cytochrome b are consistent with bis-histidine coordination of both hemes although the possibility that one of the hemes is ligated by histidine and lysine cannot be rigorously excluded.	Histidine	174-183	cytochrome b	Saccharomyces cerevisiae S288C	137-149
2584190-4	1989	Acylation of hCG at progressively lower pH values (conditions in which 1 of the 2 absolutely conserved histidines alpha His-83 is not titratable, whereas alpha His-94 becomes increasingly protonated and resistant to modification) produced hCG derivatives with a greater retention of receptor-binding activity than cell-stimulating activity.	Histidine	103-113	chorionic gonadotropin subunit beta 5	Homo sapiens	13-16
2584190-4	1989	Acylation of hCG at progressively lower pH values (conditions in which 1 of the 2 absolutely conserved histidines alpha His-83 is not titratable, whereas alpha His-94 becomes increasingly protonated and resistant to modification) produced hCG derivatives with a greater retention of receptor-binding activity than cell-stimulating activity.	Histidine	120-123	chorionic gonadotropin subunit beta 5	Homo sapiens	13-16
2689597-3	1989	The nuclear magnetic resonance spectroscopy shows that the mode of coordination of Zn(II) to LHRH consists of binding to the imidazole nitrogen and the peptide oxygen of the His-Trp bond.	Histidine	174-177	gonadotropin releasing hormone 1	Homo sapiens	93-97
2556391-2	1989	Variant forms of mammalian gonadotropin-releasing hormone (GnRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly.NH2) are present in chicken ([Gln8] GnRH and [His5, Trp7, Tyr8]GnRH), salmon ([Trp7, Leu8]GnRH), and lamprey ([Tyr3, Leu5, Glu6, Trp7, Lys8] GnRH).	Histidine	71-74	gonadotropin releasing hormone 1	Homo sapiens	59-63
2584190-4	1989	Acylation of hCG at progressively lower pH values (conditions in which 1 of the 2 absolutely conserved histidines alpha His-83 is not titratable, whereas alpha His-94 becomes increasingly protonated and resistant to modification) produced hCG derivatives with a greater retention of receptor-binding activity than cell-stimulating activity.	Histidine	160-163	chorionic gonadotropin subunit beta 5	Homo sapiens	13-16
2556391-2	1989	Variant forms of mammalian gonadotropin-releasing hormone (GnRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly.NH2) are present in chicken ([Gln8] GnRH and [His5, Trp7, Tyr8]GnRH), salmon ([Trp7, Leu8]GnRH), and lamprey ([Tyr3, Leu5, Glu6, Trp7, Lys8] GnRH).	Histidine	71-74	gonadotropin releasing hormone 1	Homo sapiens	143-147
2556391-2	1989	Variant forms of mammalian gonadotropin-releasing hormone (GnRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly.NH2) are present in chicken ([Gln8] GnRH and [His5, Trp7, Tyr8]GnRH), salmon ([Trp7, Leu8]GnRH), and lamprey ([Tyr3, Leu5, Glu6, Trp7, Lys8] GnRH).	Histidine	71-74	gonadotropin releasing hormone 1	Homo sapiens	143-147
2556391-2	1989	Variant forms of mammalian gonadotropin-releasing hormone (GnRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly.NH2) are present in chicken ([Gln8] GnRH and [His5, Trp7, Tyr8]GnRH), salmon ([Trp7, Leu8]GnRH), and lamprey ([Tyr3, Leu5, Glu6, Trp7, Lys8] GnRH).	Histidine	71-74	gonadotropin releasing hormone 1	Homo sapiens	143-147
2556391-2	1989	Variant forms of mammalian gonadotropin-releasing hormone (GnRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly.NH2) are present in chicken ([Gln8] GnRH and [His5, Trp7, Tyr8]GnRH), salmon ([Trp7, Leu8]GnRH), and lamprey ([Tyr3, Leu5, Glu6, Trp7, Lys8] GnRH).	Histidine	71-74	gonadotropin releasing hormone 1	Homo sapiens	143-147
2479414-0	1989	Site-directed mutagenesis of histidine-13 and histidine-114 of human angiogenin.	Histidine	29-38	angiogenin	Homo sapiens	69-79
2512185-6	1989	These results indicate that (1) TRH accelerates metabolic rate of catecholamine in the central nervous system as well as peripheral tissues, and (2) TRH acts on both noradrenergic and dopaminergic neurons in cerebral hemisphere, diencephalon and midbrain, whereas cyclo(His-Pro) acts mainly on dopaminergic neurons in cerebellum, pons and medulla oblongata.	Histidine	270-273	thyrotropin releasing hormone	Rattus norvegicus	149-152
2681686-1	1989	Endopeptidase (EP) 24.15 cleaves the Tyr5-Gly6 bond of luteinizing hormone-releasing hormone (LHRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2), and is the primary LHRH degrading enzyme in pituitary and hypothalamic membrane preparations.	Histidine	106-109	gonadotropin releasing hormone 1	Homo sapiens	55-92
2681686-1	1989	Endopeptidase (EP) 24.15 cleaves the Tyr5-Gly6 bond of luteinizing hormone-releasing hormone (LHRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2), and is the primary LHRH degrading enzyme in pituitary and hypothalamic membrane preparations.	Histidine	106-109	gonadotropin releasing hormone 1	Homo sapiens	94-98
2681686-1	1989	Endopeptidase (EP) 24.15 cleaves the Tyr5-Gly6 bond of luteinizing hormone-releasing hormone (LHRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2), and is the primary LHRH degrading enzyme in pituitary and hypothalamic membrane preparations.	Histidine	106-109	gonadotropin releasing hormone 1	Homo sapiens	167-171
2479414-0	1989	Site-directed mutagenesis of histidine-13 and histidine-114 of human angiogenin.	Histidine	46-55	angiogenin	Homo sapiens	69-79
2479414-2	1989	The roles of His-13 and His-114 in the ribonucleolytic and angiogenic activities of human angiogenin have been investigated by site-directed mutagenesis.	Histidine	13-16	angiogenin	Homo sapiens	90-100
2479414-2	1989	The roles of His-13 and His-114 in the ribonucleolytic and angiogenic activities of human angiogenin have been investigated by site-directed mutagenesis.	Histidine	24-27	angiogenin	Homo sapiens	90-100
2689215-0	1989	Site-directed mutagenesis of histidine 62 in the "basic patch" region of yeast phosphoglycerate kinase.	Histidine	29-38	phosphoglycerate kinase	Saccharomyces cerevisiae S288C	79-102
2549026-3	1989	In the current study we demonstrate that this apparent Ca2+ channel function is specifically inhibited by the synthetic analogue of the fibrinogen gamma COOH-terminal peptide, His-His-Leu-Gly-Gly-Ala-Lys-Gln-Ala-Gly-Asp-Val (His-12-Val), but not by the adhesive protein sequence Arg-Gly-Asp-Ser (RGDS).	Histidine	176-179	ral guanine nucleotide dissociation stimulator	Homo sapiens	296-300
2549026-3	1989	In the current study we demonstrate that this apparent Ca2+ channel function is specifically inhibited by the synthetic analogue of the fibrinogen gamma COOH-terminal peptide, His-His-Leu-Gly-Gly-Ala-Lys-Gln-Ala-Gly-Asp-Val (His-12-Val), but not by the adhesive protein sequence Arg-Gly-Asp-Ser (RGDS).	Histidine	180-183	ral guanine nucleotide dissociation stimulator	Homo sapiens	296-300
2480821-6	1989	During the isolation procedure an N-terminally modified form of VIP (Des-His, or 2-28 cod VIP) was also isolated.	Histidine	73-76	VIP peptides	Cavia porcellus	64-67
2545227-7	1989	The binding of [3H]Me-TRH to caudal lobe membranes was displaced by Me-TRH, TRH, pGlu-His-Pro-Gly-NH2 and [Glu1]-TRH, with half-maximal effective doses of 33 nM, 70.7 nM, 1.23 microM and 22 microM respectively, but not by [Phe2]-TRH, TRH free acid or His-Pro-diketopiperazine.	Histidine	86-89	thyrotropin releasing hormone	Gallus gallus	22-25
2545227-7	1989	The binding of [3H]Me-TRH to caudal lobe membranes was displaced by Me-TRH, TRH, pGlu-His-Pro-Gly-NH2 and [Glu1]-TRH, with half-maximal effective doses of 33 nM, 70.7 nM, 1.23 microM and 22 microM respectively, but not by [Phe2]-TRH, TRH free acid or His-Pro-diketopiperazine.	Histidine	251-254	thyrotropin releasing hormone	Gallus gallus	22-25
2547609-3	1989	Our sequence data shows that the histidine at residue 47 of ADH beta 2 is encoded by CAC.	Histidine	33-42	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	64-70
2660141-3	1989	We show here that substitution of a highly conserved lysine in the presumed ATP-binding site of this domain impairs the derepression of histidine biosynthetic genes under GCN4 control.	Histidine	136-145	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	171-175
2697466-4	1989	Since this DNA fragment could complement histidine auxotrophy of both C. maltosa CH1 and S. cerevisiae (his5-), we termed the gene contained in this DNA fragment C-HIS5.	Histidine	41-50	histidinol-phosphate transaminase	Saccharomyces cerevisiae S288C	104-108
2752047-2	1989	The proton NMR spectrum of the deoxy myoglobin exhibits an NH signal from the proximal histidine at 78.6 ppm, indicating heme incorporation into the heme pocket to form the Fe-N(His-F8) bond.	Histidine	87-96	myoglobin	Physeter catodon	37-46
2752047-2	1989	The proton NMR spectrum of the deoxy myoglobin exhibits an NH signal from the proximal histidine at 78.6 ppm, indicating heme incorporation into the heme pocket to form the Fe-N(His-F8) bond.	Histidine	178-181	myoglobin	Physeter catodon	37-46
2753081-0	1989	Receptor binding of fluorinated histidine analogs of thyrotropin-releasing hormone in various regions of the rat brain.	Histidine	32-41	thyrotropin releasing hormone	Rattus norvegicus	53-82
2697466-4	1989	Since this DNA fragment could complement histidine auxotrophy of both C. maltosa CH1 and S. cerevisiae (his5-), we termed the gene contained in this DNA fragment C-HIS5.	Histidine	41-50	histidinol-phosphate transaminase	Saccharomyces cerevisiae S288C	164-168
2742856-11	1989	The high pK and low enthalpy of ionization suggest that the protonation state of the His-467"-Glu-472" ion pair observed in the structure of human erythrocyte glutathione reductase influences proton-transfer steps occurring in the oxidative half-reaction.	Histidine	85-88	glutathione-disulfide reductase	Homo sapiens	159-180
2550426-7	1989	We have now constructed a human insulin receptor mutant in which 3 residues in this sequence were altered (Thr-Cys-Pro-Pro-Pro-Tyr-Tyr-His-Phe-Gln-Asp to Thr-Cys-Pro-Arg-Arg-Tyr-Tyr-Asp-Phe-Gln-Asp) and have expressed this mutant in rat hepatoma (HTC) cells.	Histidine	135-138	insulin receptor	Homo sapiens	32-48
2497223-0	1989	Effects of hypothyroidism, tri-iodothyronine and glucocorticoids on growth hormone responses to growth hormone-releasing hormone and His-D-Trp-Ala-Trp-D-Phe-Lys-NH2.	Histidine	133-136	gonadotropin releasing hormone receptor	Rattus norvegicus	68-82
2786396-1	1989	It was shown that exposure of mice AKR and (CBA X C57B1/6)F1 to Bacillus intermedius RNAase and its derivative selectively inactivated by the active centre histidine stimulated T-lymphocyte maturation.	Histidine	156-165	complement component 6	Mus musculus	50-60
2545246-0	1989	Resonance Raman evidence that distal histidine protonation removes the steric hindrance to upright binding of carbon monoxide by myoglobin.	Histidine	37-46	myoglobin	Physeter catodon	129-138
2493964-2	1989	In the present study, microinjection of 10 ng to 5 micrograms of TRH into the anterior hypothalamus (AHy) dose-dependently suppressed heat production in interscapular brown adipose tissue (BAT) in chloral hydrate-anaesthetized rats tested at a room temperature of 23 +/- 2 degrees C. This effect of TRH was mimicked by the structurally related peptides acid-TRH and luteinizing hormone releasing hormone (LH-RH), and by the TRH analog CG 3509, but not by the TRH fragments pGlu-His and His-Pro.	Histidine	478-481	thyrotropin releasing hormone	Rattus norvegicus	65-68
2646637-4	1989	These assignments provide the basis for interpreting NMR data which demonstrate that the solution structure of hTGF alpha includes an antiparallel beta-sheet involving residues Gly-19 to Leu-24 and Lys-29 to Cys-34 and a second, smaller, antiparallel beta-sheet involving residues Tyr-38 and Val-39 and His-45 and Ala-46.	Histidine	303-306	transforming growth factor alpha	Homo sapiens	111-121
2742853-9	1989	These results indicate that PRI inhibition minimally involves the three residues critical for the activity of angiogenin--Lys-40, His-13, and His-114--and to a lesser extent its single tryptophan, Trp-89.	Histidine	130-133	angiogenin	Homo sapiens	110-120
2497688-4	1989	To identify the TRH precursor in the rat hypothalamus, an antiserum was raised against the synthetic decapeptide sequence, Cys-Lys-Arg-Gln-His-Pro-Gly-Lys-Arg-Cys.	Histidine	139-142	thyrotropin releasing hormone	Rattus norvegicus	16-19
2699758-3	1989	Vasoactive intestinal polypeptide (VIP) and peptide with N- and C-terminal histidine (PHI) are released together with acetylcholine from parasympathetic nerves.	Histidine	75-84	glucose-6-phosphate isomerase	Homo sapiens	86-89
2481394-4	1989	A sequence comparison of this and tissue kallikrein (pancreatic kallikrein) indicates the key a.a. residues for serine protease activity (HIS-ASP-SER) and cleavage specificity at basic a.a. Northern blot analysis using a specific oligonucleotide probe reveals that this gene is expressed specifically in the kidney but not in the pancreas.	Histidine	138-141	kallikrein 1-related peptidase B3	Rattus norvegicus	53-74
2742853-9	1989	These results indicate that PRI inhibition minimally involves the three residues critical for the activity of angiogenin--Lys-40, His-13, and His-114--and to a lesser extent its single tryptophan, Trp-89.	Histidine	142-145	angiogenin	Homo sapiens	110-120
2500352-0	1989	Radioimmunoassay for thyrotropin-releasing hormone precursor peptide, Lys-Arg-Gln-His-Pro-Gly-Arg-Arg.	Histidine	82-85	thyrotropin releasing hormone	Rattus norvegicus	21-50
2904432-8	1988	The energies of the catecholate to Fe(III) charge-transfer transitions indicate a mixture of histidines and carboxylate(s) coordinated to the iron center in tyrosine hydroxylase.	Histidine	93-103	tyrosine hydroxylase	Bos taurus	157-177
2846539-4	1988	The codons for the two presumed active sites of protein disulfide isomerase, each a Cys-Gly-His-Cys sequence, are located 12 base pairs from the beginning of exons 2 and 9.	Histidine	92-95	prolyl 4-hydroxylase subunit beta	Homo sapiens	48-75
3076850-2	1988	It is related to several other peptides including PHI (peptide with N-terminal histidine and C-terminal isoleucine amide), secretin, glucagon, and has some sequences similar to those of growth hormone releasing hormone (Fig.	Histidine	79-88	glucose-6-phosphate isomerase	Homo sapiens	50-53
2500352-1	1989	A radioimmunoassay for thyrotropin-releasing hormone (TRH) precursor peptide Lys-Arg-Gln-His-Pro-Gly-Arg-Arg (pro-TRH), has been developed.	Histidine	89-92	thyrotropin releasing hormone	Rattus norvegicus	23-52
2500352-1	1989	A radioimmunoassay for thyrotropin-releasing hormone (TRH) precursor peptide Lys-Arg-Gln-His-Pro-Gly-Arg-Arg (pro-TRH), has been developed.	Histidine	89-92	thyrotropin releasing hormone	Rattus norvegicus	110-117
2500352-2	1989	Anti-pro-TRH antibody was raised in rabbits immunized with a conjugate of synthetic pro-TRH analog, Cys-Lys-Arg-Gln-His-Pro-Gly-Arg-Arg-Cys (pCC10) to bovine serum albumin.	Histidine	116-119	thyrotropin releasing hormone	Rattus norvegicus	5-12
2854108-1	1988	Histamine (HA) is synthesized from L-histidine by histidine decarboxylase (HDC), and HA released from neurons is predominantly methylated to tele-methylhistamine (t-MH), which is further metabolized by MAO.	Histidine	35-46	histidine decarboxylase	Rattus norvegicus	75-78
2849988-8	1988	Sequence comparisons of RSKG-7, RSKG-3, and other kallikrein-related enzymes reveal the key amino acid residues needed for both serine protease activity (His/Asp/Ser) and kallikrein-like cleavage specificity at basic amino acids.	Histidine	154-157	kallikrein 1-related peptidase C8	Rattus norvegicus	128-143
2500352-2	1989	Anti-pro-TRH antibody was raised in rabbits immunized with a conjugate of synthetic pro-TRH analog, Cys-Lys-Arg-Gln-His-Pro-Gly-Arg-Arg-Cys (pCC10) to bovine serum albumin.	Histidine	116-119	thyrotropin releasing hormone	Rattus norvegicus	84-91
2493964-2	1989	In the present study, microinjection of 10 ng to 5 micrograms of TRH into the anterior hypothalamus (AHy) dose-dependently suppressed heat production in interscapular brown adipose tissue (BAT) in chloral hydrate-anaesthetized rats tested at a room temperature of 23 +/- 2 degrees C. This effect of TRH was mimicked by the structurally related peptides acid-TRH and luteinizing hormone releasing hormone (LH-RH), and by the TRH analog CG 3509, but not by the TRH fragments pGlu-His and His-Pro.	Histidine	486-489	thyrotropin releasing hormone	Rattus norvegicus	65-68
3126296-10	1988	We further suggest that the high selectivity of potent renin inhibitors known to be only weak pepsin and cathepsin D inhibitors is due in part to the extent of histidine protonation at P2 arising from pH differences in the inhibition kinetics assay of renin (neutral conditions) compared to other aspartic proteinases (acid pH 2-4).	Histidine	160-169	cathepsin D	Homo sapiens	105-116
2912443-0	1989	Distal His----Arg mutation in bovine myoglobin results in a ligand binding site similar to the abnormal beta site of hemoglobin Zurich (beta 63 His----Arg).	Histidine	7-10	myoglobin	Bos taurus	37-46
3044690-13	1988	The active-site histidine of glutathione reductase functions primarily as the proton donor during catalysis.	Histidine	16-25	glutathione-disulfide reductase	Homo sapiens	29-50
3044690-14	1988	While the active-site histidine of lipoamide dehydrogenase stabilizes the thiolate anion intermediate and relays a proton in the catalytic process.	Histidine	22-31	dihydrolipoamide dehydrogenase	Homo sapiens	35-58
3186740-0	1988	Ligand binding to synthetic mutant myoglobin (His-E7----Gly): role of the distal histidine.	Histidine	46-49	myoglobin	Physeter catodon	35-44
3207680-5	1988	Present chemical modification results identify two distinct tissue types of ACAT, based on marked differences in reactivity of an active-site histidine residue toward diethyl pyrocarbonate (DEP) and acetic anhydride.	Histidine	142-151	sterol O-acyltransferase 1	Homo sapiens	76-80
3207680-9	1988	Oleoyl-CoA provided partial protection against inactivation by DEP and acetic anhydride, suggesting that the modified histidine is at or near the active site of ACAT.	Histidine	118-127	sterol O-acyltransferase 1	Homo sapiens	161-165
2706244-3	1989	Elution of ER was obtained by chelating agents or by imidazole, thus indicating that histidine residues on the ER molecule are involved in the interaction with the metal.	Histidine	85-94	estrogen receptor 1	Bos taurus	11-13
3207681-4	1988	We have previously reported inhibition of microsomal ACAT by histidine and sulfhydryl-selective chemical modification reagents and present here a more detailed analysis of the effect of sulfhydryl modification on ACAT activity.	Histidine	61-70	sterol O-acyltransferase 1	Homo sapiens	53-57
3427072-3	1987	Residue His-56 in the valyl-tRNA synthetase begins a HIGH sequence, and there is a threonine at position 52, one position closer to the histidine than in the tyrosyl-tRNA synthetase.	Histidine	8-11	valyl-tRNA synthetase 1	Homo sapiens	22-43
3427072-3	1987	Residue His-56 in the valyl-tRNA synthetase begins a HIGH sequence, and there is a threonine at position 52, one position closer to the histidine than in the tyrosyl-tRNA synthetase.	Histidine	136-145	valyl-tRNA synthetase 1	Homo sapiens	22-43
3427072-7	1987	Thr-52 and His-56 of the valyl-tRNA synthetase contribute little binding energy to valine, ATP, and Val-AMP.	Histidine	11-14	valyl-tRNA synthetase 1	Homo sapiens	25-46
2706244-3	1989	Elution of ER was obtained by chelating agents or by imidazole, thus indicating that histidine residues on the ER molecule are involved in the interaction with the metal.	Histidine	85-94	estrogen receptor 1	Bos taurus	111-113
2456309-3	1988	After treatment with pyroglutamyl aminopeptidase, N-terminal sequencing indicated that Gln74 of MBP formed the N-terminal residue of peptide C. A rabbit antiserum was raised to a synthetic peptide containing the sequence Pyroglu-Lys-Ser-His-Gly-Arg, corresponding to the first six residues of peptide C. By immunoblotting this serum reacted with peptide C but not with intact MBP.	Histidine	237-240	myelin basic protein	Homo sapiens	96-99
3167026-5	1988	We have identified the active site peptide containing the redox-active disulfide, a peptide corresponding to the histidine-467 region of human erythrocyte glutathione reductase, as well as the flavin binding domain that is highly conserved in all disulfide-containing flavoprotein reductase enzymes.	Histidine	113-122	glutathione-disulfide reductase	Homo sapiens	155-176
3346227-1	1988	The amino acid diphthamide is a complex post-translational derivative of histidine that exists in eukaryotic and Archaebacterial elongation factor 2 (EF-2).	Histidine	73-82	elongation factor 2	Cricetulus griseus	129-148
3346227-1	1988	The amino acid diphthamide is a complex post-translational derivative of histidine that exists in eukaryotic and Archaebacterial elongation factor 2 (EF-2).	Histidine	73-82	elongation factor 2	Cricetulus griseus	150-154
3349027-8	1988	Both His-13 and His-114 in the angiogenin peptides are required for activity since their substitution by alanine yields inactive complexes.	Histidine	5-8	angiogenin	Homo sapiens	31-41
3349027-8	1988	Both His-13 and His-114 in the angiogenin peptides are required for activity since their substitution by alanine yields inactive complexes.	Histidine	16-19	angiogenin	Homo sapiens	31-41
2443589-7	1987	The water-soluble singlet oxygen scavengers L-histidine (50 mmol/L) and sodium azide (100 mmol/L) completely prevented the photodynamic effects of uroporphyrin (100 mumol/L) on HBP.	Histidine	44-55	heme binding protein 1	Homo sapiens	177-180
3622513-8	1987	Residue 47 is His in beta 2 and Arg in the beta 1, gamma 1, and gamma 2 subunits, and in horse liver alcohol dehydrogenase.	Histidine	14-17	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	21-27
3555624-2	1987	Its amino acid composition was determined and found to be very similar to that of the nonspecific lipid transfer protein from bovine and rat liver with, as main feature, the absence of arginine, histidine and tyrosine.	Histidine	195-204	sterol carrier protein 2	Homo sapiens	86-120
3099113-4	1986	Because this last step in the biosynthesis of TRH is rate limiting for pGlu-His-Pro-Gly, we have combined several chromatographic and radioimmunoassay techniques to identify this TRH precursor in rat prostate.	Histidine	76-79	thyrotropin releasing hormone	Rattus norvegicus	46-49
3099113-4	1986	Because this last step in the biosynthesis of TRH is rate limiting for pGlu-His-Pro-Gly, we have combined several chromatographic and radioimmunoassay techniques to identify this TRH precursor in rat prostate.	Histidine	76-79	thyrotropin releasing hormone	Rattus norvegicus	179-182
3022799-3	1986	Transverse 1H NMR relaxation measurements have been used to investigate the interaction of SL-Phe with hemoglobin molecules by use of the resonances assigned to the C2 protons of the beta 2 His, the beta 143 His, and the beta 146 or beta 97 His residues as intrinsic probes.	Histidine	190-193	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	183-189
3022799-4	1986	Distance calculations using the paramagnetically induced relaxation data suggest that the SL-Phe binding site is approximately 12-16 A away from the C2 protons of the beta 2 His and the beta 146 or beta 97 His residues in the (carbonmonoxy)hemoglobin tetramer; for deoxyhemoglobin, the distances are approximately 14-17 A between the SL-Phe binding site and the C2 protons of the beta 2 His, the beta 143 His, and the beta 146 His residues.	Histidine	174-177	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	167-173
3527256-5	1986	The nine resonance peaks observed in the CIDNP spectrum of yeast phosphoglycerate kinase have been assigned tentatively to five residues: histidines-53 and -151, tryptophan-310, and tyrosines-48 and -195.	Histidine	138-148	phosphoglycerate kinase	Saccharomyces cerevisiae S288C	65-88
2424496-6	1986	The high degree of sequence homology between angiogenin and the pancreatic ribonucleases, which includes all three catalytic residues, His-12, Lys-41, and His-119, has thus identified the chemical nature of a potential angiogenin substrate.	Histidine	135-138	angiogenin	Homo sapiens	45-55
2424496-6	1986	The high degree of sequence homology between angiogenin and the pancreatic ribonucleases, which includes all three catalytic residues, His-12, Lys-41, and His-119, has thus identified the chemical nature of a potential angiogenin substrate.	Histidine	135-138	angiogenin	Homo sapiens	219-229
2424496-6	1986	The high degree of sequence homology between angiogenin and the pancreatic ribonucleases, which includes all three catalytic residues, His-12, Lys-41, and His-119, has thus identified the chemical nature of a potential angiogenin substrate.	Histidine	155-158	angiogenin	Homo sapiens	45-55
2424496-6	1986	The high degree of sequence homology between angiogenin and the pancreatic ribonucleases, which includes all three catalytic residues, His-12, Lys-41, and His-119, has thus identified the chemical nature of a potential angiogenin substrate.	Histidine	155-158	angiogenin	Homo sapiens	219-229
2420333-12	1986	Both release of endogenous histamine and formation of radiolabeled histamine from labeled histidine were inhibited by the histidine decarboxylase inhibitor alpha-fluoromethylhistidine (10 microM).	Histidine	90-99	histidine decarboxylase	Rattus norvegicus	122-145
4074786-0	1985	[Structural role of histidine residues in NAD(P)-glutamate dehydrogenase from the bovine liver].	Histidine	20-29	glutamate dehydrogenase 1, mitochondrial	Bos taurus	49-72
4074786-5	1985	These data testify to the structural role of histidine residues in the GDH molecule.	Histidine	45-54	glutamate dehydrogenase 1, mitochondrial	Bos taurus	71-74
2865955-3	1985	The participation of "thyroliberinase", a metalloenzyme which cleaves TRH at the pyroglutamyl-His bond was implied.	Histidine	94-97	thyrotropin releasing hormone	Homo sapiens	70-73
3161731-10	1985	The amino acid compositions of GP Ib beta and GP IX were similar but showed marked differences in the levels of glutamic acid, alanine, histidine and arginine.	Histidine	136-145	glycoprotein IX platelet	Homo sapiens	46-51
3929378-1	1985	A rabbit antiserum to a peptide sequence present in the precursor for thyrotropin-releasing hormone (proTRH), deduced from cloned amphibian-skin complementary DNA, was raised by immunization with the synthetic decapeptide Cys-Lys-Arg-Gln-His-Pro-Gly-Lys-Arg-Cys (proTRH-SH).	Histidine	238-241	thyrotropin releasing hormone	Rattus norvegicus	70-99
3928488-1	1985	Inhibition of renin was induced in conscious marmosets with CGP 29 287, Z-Arg-Arg-Pro-Phe-His-Sta-Ile-His-Lys (Boc)-OMe, a renin inhibitor with a prolonged duration of action.	Histidine	90-93	renin	Rattus norvegicus	14-19
2862917-1	1985	Kinetic studies of pig kidney dipeptidyl peptidase IV (dipeptidyl-peptide hydrolase, EC 3.4.14.5) were carried out using substrates possessing a side-chain of different length at the P2 position (or amino-terminal position in this case) such as Lys-, Arg-, Phe-, Met-, Ser-, His-, Glu- and Gly-Pro-pNA.	Histidine	275-278	dipeptidyl peptidase 4	Sus scrofa	30-53
2991197-3	1985	Tox+ recombinants showed the same linkage properties to the his locus as to the previously mapped tox locus of 569B.	Histidine	60-63	thymocyte selection associated high mobility group box	Homo sapiens	0-3
3927185-3	1985	On the other hand, p-Glu-His-Pro-OH (TRH-free acid), another metabolite of TRH caused significant inhibition (21%) at 10(-4) M concentration.	Histidine	25-28	thyrotropin releasing hormone	Rattus norvegicus	37-40
3926449-1	1985	We studied the in vitro synthesis of thyrotropin releasing hormone (TRH) by pancreatic cells, using [14C]histidine incorporation and radioimmunoassay.	Histidine	105-114	thyrotropin releasing hormone	Rattus norvegicus	37-66
3926449-1	1985	We studied the in vitro synthesis of thyrotropin releasing hormone (TRH) by pancreatic cells, using [14C]histidine incorporation and radioimmunoassay.	Histidine	105-114	thyrotropin releasing hormone	Rattus norvegicus	68-71
3918765-1	1985	Histidyl-proline diketopiperazine (His-Pro DKP) has been proposed as a metabolite of thyrotropin releasing hormone (TRH).	Histidine	0-3	thyrotropin releasing hormone	Rattus norvegicus	85-114
3918765-1	1985	Histidyl-proline diketopiperazine (His-Pro DKP) has been proposed as a metabolite of thyrotropin releasing hormone (TRH).	Histidine	0-3	thyrotropin releasing hormone	Rattus norvegicus	116-119
6378668-5	1984	Thus, Arg-47 in beta 1 is substituted by His in beta 2-Bern.	Histidine	41-44	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	48-54
6385771-0	1984	Renin cleavage of a human kidney renin substrate analogous to human angiotensinogen, H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH, that is human renin specific and is resistant to cathepsin D.	Histidine	107-110	cathepsin D	Homo sapiens	196-207
6385771-0	1984	Renin cleavage of a human kidney renin substrate analogous to human angiotensinogen, H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH, that is human renin specific and is resistant to cathepsin D.	Histidine	119-122	cathepsin D	Homo sapiens	196-207
6385771-0	1984	Renin cleavage of a human kidney renin substrate analogous to human angiotensinogen, H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH, that is human renin specific and is resistant to cathepsin D.	Histidine	119-122	cathepsin D	Homo sapiens	196-207
6093073-5	1984	In the amygdala, binding was inhibited in the presence of TRH and Me-TRH but not in the presence of up to 1 microM concentrations of cyclo (His-Pro), TRH-OH, pGlu-His or peptides unrelated to TRH.	Histidine	163-166	thyrotropin releasing hormone	Homo sapiens	58-61
6472496-2	1984	This method involved conversion of [3H]histidine into [3H]histamine by the enzyme sample, with methylation of this product in situ, catalysed by the enzyme histamine N-methyltransferase, to yield [3H]N-tele-methylhistamine.	Histidine	35-48	histamine N-methyltransferase	Mus musculus	156-185
6374651-3	1984	Here, the beta 2 form has a histidine residue, while, in common with other characterized mammalian liver alcohol dehydrogenases, the beta 1 form has an arginine residue.	Histidine	28-37	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	10-16
6374651-5	1984	The histidine/arginine-47 mutational replacement corresponds to a position that binds the pyrophosphate group of the coenzyme NAD(H); this explains the functional differences between the beta 1 beta 1 and beta 2 beta 2 isozymes, including both a lower pH optimum and higher turnover number of beta 2 beta 2, which is likely to be the mutant form.	Histidine	4-13	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	205-211
6374651-5	1984	The histidine/arginine-47 mutational replacement corresponds to a position that binds the pyrophosphate group of the coenzyme NAD(H); this explains the functional differences between the beta 1 beta 1 and beta 2 beta 2 isozymes, including both a lower pH optimum and higher turnover number of beta 2 beta 2, which is likely to be the mutant form.	Histidine	4-13	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	212-218
6374651-5	1984	The histidine/arginine-47 mutational replacement corresponds to a position that binds the pyrophosphate group of the coenzyme NAD(H); this explains the functional differences between the beta 1 beta 1 and beta 2 beta 2 isozymes, including both a lower pH optimum and higher turnover number of beta 2 beta 2, which is likely to be the mutant form.	Histidine	4-13	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	212-218
6374651-5	1984	The histidine/arginine-47 mutational replacement corresponds to a position that binds the pyrophosphate group of the coenzyme NAD(H); this explains the functional differences between the beta 1 beta 1 and beta 2 beta 2 isozymes, including both a lower pH optimum and higher turnover number of beta 2 beta 2, which is likely to be the mutant form.	Histidine	4-13	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	212-218
6427768-0	1984	Glycine-directed peptide amidation: presence in rat brain of two enzymes that convert p-Glu-His-Pro-Gly-OH into p-Glu-His-Pro-NH2 (thyrotropin-releasing hormone).	Histidine	92-95	thyrotropin releasing hormone	Rattus norvegicus	131-160
6651842-1	1983	Bovine liver Cu,Zn superoxide dismutase (SOD) is inactivated by hydrogen peroxide at alkaline pH, and full inactivation correlates with the loss of 1.1 histidine/subunit.	Histidine	152-161	superoxide dismutase [Cu-Zn]	Bos taurus	13-39
6317621-1	1983	High levels of thyrotropin releasing hormone (TRH) and TRH-homologous peptide, with the general structure pGlu=X-Pro-NH2 where X is either Histidine (His) or a neutral amino acid residue, have been identified in rat and human prostate (Pekary et al, 1980, 1981a, 1982c).	Histidine	139-148	thyrotropin releasing hormone	Rattus norvegicus	15-44
6317621-1	1983	High levels of thyrotropin releasing hormone (TRH) and TRH-homologous peptide, with the general structure pGlu=X-Pro-NH2 where X is either Histidine (His) or a neutral amino acid residue, have been identified in rat and human prostate (Pekary et al, 1980, 1981a, 1982c).	Histidine	139-148	thyrotropin releasing hormone	Rattus norvegicus	55-58
6317621-1	1983	High levels of thyrotropin releasing hormone (TRH) and TRH-homologous peptide, with the general structure pGlu=X-Pro-NH2 where X is either Histidine (His) or a neutral amino acid residue, have been identified in rat and human prostate (Pekary et al, 1980, 1981a, 1982c).	Histidine	139-142	thyrotropin releasing hormone	Rattus norvegicus	15-44
6317621-1	1983	High levels of thyrotropin releasing hormone (TRH) and TRH-homologous peptide, with the general structure pGlu=X-Pro-NH2 where X is either Histidine (His) or a neutral amino acid residue, have been identified in rat and human prostate (Pekary et al, 1980, 1981a, 1982c).	Histidine	139-142	thyrotropin releasing hormone	Rattus norvegicus	55-58
6315008-10	1983	On further fragmentation with cathepsin D, a dodecapeptide containing ADP-ribose moiety was isolated whose structure was determined as: Asp-Glu-Glu-Leu-His-Arg-Gly-Tyr-Arg*-Asp-Arg-Tyr.	Histidine	152-155	cathepsin D	Homo sapiens	30-41
6688711-5	1983	Phosphopyridoxamidation identifies the suppressive effect on the electron transferase activity of carboxyl groups proximal to the catalytic histidine residue of lipoamide dehydrogenase.	Histidine	140-149	dihydrolipoamide dehydrogenase	Homo sapiens	161-184
6189384-4	1983	Programmed atrial stimulation revealed that NAPA had no discernible effects on AV nodal conduction; however, it exerted depressive effects on the His-Purkinje system in 9 of 16 patients.	Histidine	146-149	NSF attachment protein alpha	Homo sapiens	44-48
6189384-6	1983	In 8 of 16 patients who had inducible repetitive ventricular response (RVR) because of reentry within the His-Purkinje system, NAPA narrowed or abolished the RVR zone in 3 patients and slowed the RVR rate with widening of the RVR zone in the remaining 5 patients.	Histidine	106-109	NSF attachment protein alpha	Homo sapiens	127-131
6290493-4	1982	The NH2- and COOH-terminal regions are predominantly acidic whereas an apolar and a basic region are found in the interior, Subunit VI shows between 28 and 40% sequence homology (depending on the method of alignment) with subunit V of bovine cytochrome c oxidase; since the yeast subunit VI lacks methionine and contains only a single histidine residue very close to the NH2 terminus, it is unlikely that either of the two subunits carries heme alpha in the native enzyme.	Histidine	335-344	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	242-262
6762537-5	1982	Analogs with non-aromatic or hydrophilic amino acids (X: Gly, Leu, Arg, His, Glu) in position 1 generally have much lower activities in this series of LH-RH antagonists.	Histidine	72-75	gonadotropin releasing hormone 1	Homo sapiens	151-156
6799149-3	1982	These results suggest that factors in addition to TRH concentrations are important in determining the unique concentration pattern of cyclo-(His--Pro) in the brain.	Histidine	141-144	thyrotropin releasing hormone	Rattus norvegicus	50-53
7044894-3	1981	The cloned yeast HIS5 gene weakly complemented the E. coli hisC mutation and gave rise to a slow-growing E. coli transformant without addition of histidine.	Histidine	146-155	histidinol-phosphate transaminase	Saccharomyces cerevisiae S288C	17-21
7306503-0	1981	Nuclear magnetic resonance studies of the role of histidine residues at the active site of rabbit muscle creatine kinase.	Histidine	50-59	creatine kinase M-type	Oryctolagus cuniculus	98-120
6265917-0	1981	Orientation of histidine residues in RNase A: neutron diffraction study.	Histidine	15-24	ribonuclease A family member 1, pancreatic	Homo sapiens	37-44
6796786-1	1981	The histidine residue of thyrotropin releasing factor (TRF, pGlu-His-Pro-NH2) offers the possibility of conjugating TRF to a macromolecule to produce TRF antibodies.	Histidine	4-13	thyrotropin releasing hormone	Rattus norvegicus	25-53
6796786-1	1981	The histidine residue of thyrotropin releasing factor (TRF, pGlu-His-Pro-NH2) offers the possibility of conjugating TRF to a macromolecule to produce TRF antibodies.	Histidine	4-13	thyrotropin releasing hormone	Rattus norvegicus	55-58
6796786-1	1981	The histidine residue of thyrotropin releasing factor (TRF, pGlu-His-Pro-NH2) offers the possibility of conjugating TRF to a macromolecule to produce TRF antibodies.	Histidine	4-13	thyrotropin releasing hormone	Rattus norvegicus	116-119
6796786-1	1981	The histidine residue of thyrotropin releasing factor (TRF, pGlu-His-Pro-NH2) offers the possibility of conjugating TRF to a macromolecule to produce TRF antibodies.	Histidine	4-13	thyrotropin releasing hormone	Rattus norvegicus	116-119
6796786-1	1981	The histidine residue of thyrotropin releasing factor (TRF, pGlu-His-Pro-NH2) offers the possibility of conjugating TRF to a macromolecule to produce TRF antibodies.	Histidine	65-68	thyrotropin releasing hormone	Rattus norvegicus	25-53
6796786-1	1981	The histidine residue of thyrotropin releasing factor (TRF, pGlu-His-Pro-NH2) offers the possibility of conjugating TRF to a macromolecule to produce TRF antibodies.	Histidine	65-68	thyrotropin releasing hormone	Rattus norvegicus	55-58
6796786-1	1981	The histidine residue of thyrotropin releasing factor (TRF, pGlu-His-Pro-NH2) offers the possibility of conjugating TRF to a macromolecule to produce TRF antibodies.	Histidine	65-68	thyrotropin releasing hormone	Rattus norvegicus	116-119
6796786-1	1981	The histidine residue of thyrotropin releasing factor (TRF, pGlu-His-Pro-NH2) offers the possibility of conjugating TRF to a macromolecule to produce TRF antibodies.	Histidine	65-68	thyrotropin releasing hormone	Rattus norvegicus	116-119
3118225-0	1987	Is all cyclo(His-Pro) derived from thyrotropin-releasing hormone?	Histidine	13-16	thyrotropin releasing hormone	Homo sapiens	35-64
3109909-2	1987	Peptides related to TRH were detected by trypsin digestion and radioimmunoassay with an antibody to TRH or an antibody raised against the pentapeptide Glp-His-Pro-Gly-Lys.	Histidine	155-158	thyrotropin releasing hormone	Rattus norvegicus	20-23
3104816-5	1987	The results are discussed with reference to the lack of specific binding sites in brain for the proposed neuropeptide and TRH metabolite cyclo(His-Pro).	Histidine	143-146	thyrotropin releasing hormone	Rattus norvegicus	122-125
3099113-2	1986	A species specific protein with repetitive -Gln-His-Pro-Gly- sequences, which are flanked on the N- and C-terminus by paired basic residues, has been shown to be the source of TRH in frog skin and rat hypothalamus.	Histidine	48-51	thyrotropin releasing hormone	Rattus norvegicus	176-179
3015573-2	1986	We have previously shown that a short preincubation of explants of the median eminence area with copper(II) [Cu(II)] complexed to histidine (CuHis) markedly amplifies PGE2 stimulation of LHRH release.	Histidine	130-139	gonadotropin releasing hormone 1	Homo sapiens	187-191
2869108-3	1986	Reports of a thyrotropin-releasing hormone-degrading enzyme with narrow specificity that cleaves the pGlu-His bond of this tripeptide led us to develop a coupled assay using pGlu-His-Pro-2NA as the substrate to measure this activity.	Histidine	106-109	thyrotropin releasing hormone	Rattus norvegicus	13-42
2869108-3	1986	Reports of a thyrotropin-releasing hormone-degrading enzyme with narrow specificity that cleaves the pGlu-His bond of this tripeptide led us to develop a coupled assay using pGlu-His-Pro-2NA as the substrate to measure this activity.	Histidine	179-182	thyrotropin releasing hormone	Rattus norvegicus	13-42
2869108-8	1986	The data suggest that degradation of thyrotropin-releasing hormone by the particulate fraction of a brain homogenate is catalyzed mainly by an enzyme that cleaves the pGlu-His bond of thyrotropin-releasing hormone but is distinct from pyroglutamyl peptide hydrolase.	Histidine	172-175	thyrotropin releasing hormone	Rattus norvegicus	37-66
2869108-8	1986	The data suggest that degradation of thyrotropin-releasing hormone by the particulate fraction of a brain homogenate is catalyzed mainly by an enzyme that cleaves the pGlu-His bond of thyrotropin-releasing hormone but is distinct from pyroglutamyl peptide hydrolase.	Histidine	172-175	thyrotropin releasing hormone	Rattus norvegicus	184-213
3099875-4	1986	Blood flow was also determined in anaesthetized rabbits before and after the administration of the TRH metabolites cyclo(His-Pro) and acid-TRH and after subsequent administration of 50 micrograms kg-1 TRH.	Histidine	121-124	thyrotropin releasing hormone	Oryctolagus cuniculus	99-102
3079917-3	1986	This protein contained five copies of the sequence Gln-His-Pro-Gly flanked by paired basic amino acids and could therefore generate five TRH molecules.	Histidine	55-58	thyrotropin releasing hormone	Rattus norvegicus	137-140
3080358-3	1986	The hypothalamic immunoreactive TRH (ir-TRH) content increased significantly after histidine or HA injection, decreased significantly after FA injection, but was not changed by MP.	Histidine	83-92	thyrotropin releasing hormone	Rattus norvegicus	32-35
3080358-3	1986	The hypothalamic immunoreactive TRH (ir-TRH) content increased significantly after histidine or HA injection, decreased significantly after FA injection, but was not changed by MP.	Histidine	83-92	thyrotropin releasing hormone	Rattus norvegicus	40-43
3080358-8	1986	The plasma ir-TRH and TSH responses to cold were inhibited by histidine or HA and enhanced by FA.	Histidine	62-71	thyrotropin releasing hormone	Rattus norvegicus	14-17
3080358-9	1986	The plasma TSH response to TRH was inhibited by histidine or HA and enhanced by FA.	Histidine	48-57	thyrotropin releasing hormone	Rattus norvegicus	27-30
3080358-10	1986	The inactivation of TRH immunoreactivity by hypothalamus or plasma in vitro after histidine, HA, MP or FA was not different from that of the control.	Histidine	82-91	thyrotropin releasing hormone	Rattus norvegicus	20-23
3951435-2	1986	The theoretical conformational analysis of potential surfaces of Ser-195, His-57, Asp-102 and Gln-192 side chains in the active center of native beta-trypsin has been carried out.	Histidine	74-77	serine protease 1	Homo sapiens	145-157
2933077-5	1985	Between pH 5.5 and 8, the pH profiles of kcat and kcat/Km for the Lys77-plasmin-catalyzed hydrolysis of ZLysONp and ZArgONp reflect the ionization of a single group (probably His-602 involved in the active site) with pKa values ranging between 6.4 and 6.6; at variance, values of Km are pH-independent.	Histidine	175-178	plasminogen	Homo sapiens	72-79
4083177-5	1985	Thus, the substrate binding site of histidine decarboxylase is very rigid and specific for L-histidine.	Histidine	91-102	histidine decarboxylase	Rattus norvegicus	36-59
3938299-4	1985	Some other possible relationships have been uncovered also, including a resemblance between the histidine-rich hinge regions of high molecular weight kininogen and hemopexin and between Factor VIII and Von Willebrand Factor.	Histidine	96-105	hemopexin	Homo sapiens	164-173
4029086-0	1985	Variables determining the growth hormone response of His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 in the rat.	Histidine	53-56	gonadotropin releasing hormone receptor	Rattus norvegicus	26-40
4008494-0	1985	Resonance Raman studies of CO and O2 binding to elephant myoglobin (distal His(E7)----Gln).	Histidine	75-78	myoglobin	Physeter catodon	57-66
4008494-1	1985	Carbon monoxide and dioxygen were employed as resonance Raman-visible ligands for probing the nature of the heme-binding site in elephant myoglobin, which has glutamine in the distal position (E7) instead of the usual histidine.	Histidine	218-227	myoglobin	Physeter catodon	138-147
2861083-5	1985	We also investigated a synthetic hexapeptide, His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 (GHRP), which was previously reported to have potent GH-releasing activity.	Histidine	46-49	growth hormone secretagogue receptor	Rattus norvegicus	79-83
3927185-3	1985	On the other hand, p-Glu-His-Pro-OH (TRH-free acid), another metabolite of TRH caused significant inhibition (21%) at 10(-4) M concentration.	Histidine	25-28	thyrotropin releasing hormone	Rattus norvegicus	75-78
3920663-0	1985	Intraventricular administration of cyclo(His-Pro), a metabolite of thyrotropin-releasing hormone (TRH), decreases water intake in the rat.	Histidine	41-44	thyrotropin releasing hormone	Rattus norvegicus	67-96
3920663-0	1985	Intraventricular administration of cyclo(His-Pro), a metabolite of thyrotropin-releasing hormone (TRH), decreases water intake in the rat.	Histidine	41-44	thyrotropin releasing hormone	Rattus norvegicus	98-101
3922011-4	1985	Several centrally acting TRH analogues showed varying degrees of resistance to degradation by the peptidases in the two fractions, the most stable analogue being RX77368 (pGlu-His-3,3"-dimethyl(ProNH2].	Histidine	176-179	thyrotropin releasing hormone	Homo sapiens	25-28
3922011-5	1985	Areas of human postmortem brain appear to contain two of the enzymes capable of degrading TRH, a proline endopeptidase forming TRH-OH and a pyroglutamyl aminopeptidase forming cyclo(His-Pro).	Histidine	182-185	thyrotropin releasing hormone	Homo sapiens	90-93
3853779-1	1985	Study by chemical modification of Ser, Arg, His residues and sulfhydryl groups on bovine seryl-tRNA synthetase showed that Ser residues appeared to be unnecessary for the recognition mechanism, but Arg and His residues were essential.	Histidine	44-47	seryl-tRNA synthetase 1	Bos taurus	89-110
3853779-1	1985	Study by chemical modification of Ser, Arg, His residues and sulfhydryl groups on bovine seryl-tRNA synthetase showed that Ser residues appeared to be unnecessary for the recognition mechanism, but Arg and His residues were essential.	Histidine	206-209	seryl-tRNA synthetase 1	Bos taurus	89-110
6394691-6	1984	Amino acid composition and sequence analyses confirmed the structure of this form of chicken LHRH as pGlu-His-Trp-Ser-Tyr-Gly-Leu-Gln-Pro-Gly-NH2.	Histidine	106-109	gonadotropin releasing hormone 1	Homo sapiens	93-97
6390443-6	1984	In addition, we found that copper complexed to histidine (Cu-His), but not ionic copper, stimulated LHRH release, the magnitude of which was dependent on the dose of Cu-His.	Histidine	47-56	gonadotropin releasing hormone 1	Homo sapiens	100-104
6498167-3	1984	In diamagnetic derivatives [(carbon monoxy)myoglobin (COMb) and oxymyoglobin (oxyMb)], the titration behavior of His-36 H-2 and H-4 resonances is normalized (pK approximately 6.8).	Histidine	113-116	myoglobin	Physeter catodon	43-52
6498167-4	1984	The very slight alkaline Bohr effect in sperm whale myoglobin (Mb) is interpreted in terms of the pK change of His-36 from deoxyMb to oxyMb and compensating pK changes in the opposite direction of other unspecified groups.	Histidine	111-114	myoglobin	Physeter catodon	52-61
6746625-5	1984	The essentially identical dipolar shifts and dipolar relaxation times for the distal Gln-E7 side chain NH and the distal His-E7 ring NH in sperm whale myoglobin indicate that those labile protons occupy the same geometrical position relative to the iron and heme plane.	Histidine	121-124	myoglobin	Physeter catodon	151-160
6717439-1	1984	Diphthamide, a unique amino acid, is a post-translational derivative of histidine that exists in protein synthesis elongation factor 2 at the site of diphtheria toxin-catalyzed ADP-ribosylation of elongation factor 2.	Histidine	72-81	elongation factor 2	Cricetulus griseus	115-134
6717439-1	1984	Diphthamide, a unique amino acid, is a post-translational derivative of histidine that exists in protein synthesis elongation factor 2 at the site of diphtheria toxin-catalyzed ADP-ribosylation of elongation factor 2.	Histidine	72-81	elongation factor 2	Cricetulus griseus	197-216
6712945-2	1984	Using a combination of immunologic and in vivo pulse-chase studies with radiolabeled histidine and phosphate, we show that the phosphorylated precursor of both rat and mouse filaggrin has an apparent molecular weight much higher than previously realized (6 X 10(5) and 3.9 X 10(5), respectively).	Histidine	85-94	filaggrin	Mus musculus	174-183
6322690-3	1984	Chlamydomonas calmodulin has two histidine residues similar to calmodulin from the protozoan Tetrahymena.	Histidine	33-42	uncharacterized protein	Chlamydomonas reinhardtii	14-24
6099783-1	1984	The synthetic tetradecapeptide renin substrate (TDP; Asp-arg-val-tyr-ile-his-pro-phe-his-leu-leu-val-tyr-ser) has been employed frequently to elucidate the enzymatic action of renin in vitro and, to a lesser extent, in vivo.	Histidine	73-76	renin	Rattus norvegicus	31-36
6547932-0	1984	The characterization of hemoglobin Manitoba or alpha (2)102(G9)Ser----Arg beta 2 and hemoglobin Contaldo or alpha (2)103(G10)His----Arg beta 2 by high performance liquid chromatography.	Histidine	125-128	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	74-113
6209415-2	1984	Titration of MBP by GM1 resulted in 13C NMR signal shifts for the I1e and His residues of MBP at a GM1/MBP mole ratio of one or less.	Histidine	74-77	myelin basic protein	Homo sapiens	13-16
6209415-2	1984	Titration of MBP by GM1 resulted in 13C NMR signal shifts for the I1e and His residues of MBP at a GM1/MBP mole ratio of one or less.	Histidine	74-77	myelin basic protein	Homo sapiens	90-93
6209415-2	1984	Titration of MBP by GM1 resulted in 13C NMR signal shifts for the I1e and His residues of MBP at a GM1/MBP mole ratio of one or less.	Histidine	74-77	myelin basic protein	Homo sapiens	90-93
6425995-0	1984	Potent central nervous system action of p-Glu-His-(3,3"-dimethyl)-Pro NH2, a stabilized analog of TRH, to stimulate gastric secretion in rats.	Histidine	46-49	thyrotropin releasing hormone	Rattus norvegicus	98-101
6309326-2	1983	TRH analogs competed for the binding in the following rank order of potency: MeTRH greater than TRH greater than TRH-Gly-NH2 greater than Ser-His-Pro-NH2 greater than Thr-His-Pro-NH2 greater than pGlu-His-Pro-NH-C2H5 greater than TRH-free acid.	Histidine	142-145	thyrotropin releasing hormone	Oryctolagus cuniculus	0-3
6309326-2	1983	TRH analogs competed for the binding in the following rank order of potency: MeTRH greater than TRH greater than TRH-Gly-NH2 greater than Ser-His-Pro-NH2 greater than Thr-His-Pro-NH2 greater than pGlu-His-Pro-NH-C2H5 greater than TRH-free acid.	Histidine	171-174	thyrotropin releasing hormone	Oryctolagus cuniculus	0-3
6307024-0	1983	The functional role of histidine and sulfhydryl groups in rat liver thiamine pyrophosphokinase.	Histidine	23-32	thiamin pyrophosphokinase 1	Rattus norvegicus	68-94
6307024-3	1983	Titration of the protein with DEPC has established that modification of two histidine groups decreases the catalytic activity of thiamine pyrophosphokinase.	Histidine	76-85	thiamin pyrophosphokinase 1	Rattus norvegicus	129-155
6307024-11	1983	Both histidine and sulfhydryl groups are suggested to play an important role in the catalytic mechanism of thiamine pyrophosphokinase.	Histidine	5-14	thiamin pyrophosphokinase 1	Rattus norvegicus	107-133
6830620-3	1983	The Vmax for histidine transport for cells in which decarboxylation of histidine had been completely inhibited was 11.9 pmoles per min per 10(6) cells, compared to a Vmax of 18.9 pmoles per min per 10(6) cells in the presence of active mast cell histidine decarboxylase.	Histidine	13-22	histidine decarboxylase	Rattus norvegicus	246-269
6830620-3	1983	The Vmax for histidine transport for cells in which decarboxylation of histidine had been completely inhibited was 11.9 pmoles per min per 10(6) cells, compared to a Vmax of 18.9 pmoles per min per 10(6) cells in the presence of active mast cell histidine decarboxylase.	Histidine	71-80	histidine decarboxylase	Rattus norvegicus	246-269
6820171-3	1982	Of the TRH analogues studied, RX77368 (pGlu-His-3,3"-dimethyl-ProNH2) was the most potent in this behavioural test system.	Histidine	44-47	thyrotropin releasing hormone	Rattus norvegicus	7-10
7155144-1	1982	Schiff bases condensible at pH 7.0-10 after prolonged incubation with neighbouring histidine residues to yield cyclic compounds absorbing at 330 nm are formed by means of four molecules of pyridoxal-5"-phosphate (PLP) interacting with epsilon-NH2 groups of lysine in bovine serum albumin.	Histidine	83-92	pyridoxal phosphatase	Homo sapiens	213-216
7155144-3	1982	The number of PLP molecules interacting with imidazole rings of histidine in protein remains invariable in alkaline medium, in 6-8 M guanidine.	Histidine	64-73	pyridoxal phosphatase	Homo sapiens	14-17
6897162-0	1982	Multifunctionality of lipoamide dehydrogenase: role of histidine residues in reductase reaction.	Histidine	55-64	dihydrolipoamide dehydrogenase	Homo sapiens	22-45
6813375-1	1982	To generate anti-thyrotropin-releasing hormone (TRH) antibodies TRH was rendered antigenic presumably by reaction of its histidine residue with bis-diazotized benzidine (BDB) coupled to bovine serum albumin (BSA).	Histidine	121-130	thyrotropin releasing hormone	Oryctolagus cuniculus	12-46
6813375-1	1982	To generate anti-thyrotropin-releasing hormone (TRH) antibodies TRH was rendered antigenic presumably by reaction of its histidine residue with bis-diazotized benzidine (BDB) coupled to bovine serum albumin (BSA).	Histidine	121-130	thyrotropin releasing hormone	Oryctolagus cuniculus	48-51
6813375-1	1982	To generate anti-thyrotropin-releasing hormone (TRH) antibodies TRH was rendered antigenic presumably by reaction of its histidine residue with bis-diazotized benzidine (BDB) coupled to bovine serum albumin (BSA).	Histidine	121-130	thyrotropin releasing hormone	Oryctolagus cuniculus	64-67
7250488-8	1981	The time course of the reaction of diethylpyrocarbonate with the estradiol receptor and the demonstration of hydroxylamine reversal of inhibition suggest that histidine is involved in the binding of estradiol receptor to oligodeoxyribonucleotides.	Histidine	159-168	estrogen receptor 1	Bos taurus	65-83
7250488-8	1981	The time course of the reaction of diethylpyrocarbonate with the estradiol receptor and the demonstration of hydroxylamine reversal of inhibition suggest that histidine is involved in the binding of estradiol receptor to oligodeoxyribonucleotides.	Histidine	159-168	estrogen receptor 1	Bos taurus	199-217
7309353-3	1981	With free amino acids, the osmium(VIII) reagents are most reactive with Met, Cys, His, Thr, Ser, Trp, Lys, and Pro; the osmium(VI) reagent only reacts significantly with His, Met, Cys, Thr, and Ser.	Histidine	82-85	cytochrome c oxidase subunit 8A	Homo sapiens	34-38
7309353-3	1981	With free amino acids, the osmium(VIII) reagents are most reactive with Met, Cys, His, Thr, Ser, Trp, Lys, and Pro; the osmium(VI) reagent only reacts significantly with His, Met, Cys, Thr, and Ser.	Histidine	170-173	cytochrome c oxidase subunit 8A	Homo sapiens	34-38
6928655-4	1980	We postulate that this modification system is involved in the conversion of a single histidine residue in EF-2 to the specific target of toxin-catalyzed ADP-ribosylation, the novel amino acid X.	Histidine	85-94	elongation factor 2	Cricetulus griseus	106-110
7383973-6	1980	Other differences in the amino acid sequence of the rat ceruloplasmin included an increase in methionine and cystine/cysteine, and a decrease in histidine, tyrosine and tryptophan.	Histidine	145-154	ceruloplasmin	Rattus norvegicus	56-69
221500-10	1979	It is postulated that histidine is involved in the binding of the substrate ATP to the catalytic site of pyridoxal kinase.	Histidine	22-31	pyridoxal kinase	Sus scrofa	105-121
751649-0	1978	Genetic variation in the activity of the histidine catabolic enzymes between inbred strains of mice: a structural locus for a cytosol histidine aminotransferase isozyme (Hat-1).	Histidine	41-50	histone aminotransferase 1	Mus musculus	170-175
102131-2	1978	We have studied the dynamics of cyclic compound formation between histamine or histidine and pyridoxal 5"-phosphate (Hi-PLP or His-PLP) in incubates of rat gastric mucosa histidine decarboxylase (HD), rat intestinal diamine oxidase (DAO) or homogenates of either rat liver, intestine or gastric mucosa.	Histidine	79-88	histidine decarboxylase	Rattus norvegicus	171-194
210651-6	1978	In the pathogenesis of the histamine alteration the increased histidine content in the brain of uremic rats must be considered, since the specific histidine decarboxylase is not saturated by the normal endogenous level of the amino acid precursor.	Histidine	62-71	histidine decarboxylase	Rattus norvegicus	147-170
23288-1	1977	1H NMR spectroscopy at 100 MHz was used to determine the first-order rate constants for the 1H-2H exchange of the H-2 histidine resonances of RNase-A in 2H2O at 35 degrees C and pH meter readings of 7, 9, 10 and 10.5.	Histidine	118-127	ribonuclease A family member 1, pancreatic	Homo sapiens	142-149
23288-6	1977	These changes are attributed to a conformational change in the hinge region of RNase-A (probably due to the titration of Tyr-25) which allows His-48 to become accessible to solvent.	Histidine	142-145	ribonuclease A family member 1, pancreatic	Homo sapiens	79-86
6105888-1	1980	Divalent copper and copper complexes of tyrosine, histidine and lysine inhibited at low concentrations the stearoyl-CoA desaturation reaction in both chicken liver microsomes and in a purified system consisting of chicken liver delta 9 terminal desaturase, cytochrome b5, ascorbate and liposome.	Histidine	50-59	cytochrome b5 type A	Gallus gallus	257-270
7357028-3	1980	N-Acetylhistidine accumulated preferentially in the kidney and was converted to histidine effectively by acylase I.	Histidine	8-17	aminoacylase 1	Homo sapiens	105-112
42854-2	1979	Sea anemone toxin II (ATX II) which keeps the activated sodium channels open, can be labelled at its histidine residues with 125I up to a specific radioactivity of 500 Ci/mmole.	Histidine	101-110	diencephalon/mesencephalon homeobox 1	Mus musculus	22-25
518582-0	1979	Histidine at the active centre of pig heart lipoamide dehydrogenase.	Histidine	0-9	dihydrolipoamide dehydrogenase	Sus scrofa	44-67
23288-7	1977	1H NMR spectra of S-protein and S-peptide, and of material partially deuterated at the C-2 positions of the histidine residues confirm the reassignment of the histidine resonances of RNase-A [Bradbury, J. H. &amp; Teh, J. S. (1975) Chem.	Histidine	108-117	ribonuclease A family member 1, pancreatic	Homo sapiens	183-190
23288-7	1977	1H NMR spectra of S-protein and S-peptide, and of material partially deuterated at the C-2 positions of the histidine residues confirm the reassignment of the histidine resonances of RNase-A [Bradbury, J. H. &amp; Teh, J. S. (1975) Chem.	Histidine	159-168	ribonuclease A family member 1, pancreatic	Homo sapiens	183-190
23288-12	1977	The S-protein is less stable to acid than RNase-A since the former, but not the latter, shows evidence of reversible denaturation at pH 3 and 26 degrees C. His-48 in S-protein titrates normally and has a lower pK than in RN-ase-A probably because of the absence of Asp-14, which in RN-ase-A forms a a hydrogen bond with His-48 and causes it to be inaccessible to solvent, at pH values below 9.	Histidine	156-159	ribonuclease A family member 1, pancreatic	Homo sapiens	42-49
23288-12	1977	The S-protein is less stable to acid than RNase-A since the former, but not the latter, shows evidence of reversible denaturation at pH 3 and 26 degrees C. His-48 in S-protein titrates normally and has a lower pK than in RN-ase-A probably because of the absence of Asp-14, which in RN-ase-A forms a a hydrogen bond with His-48 and causes it to be inaccessible to solvent, at pH values below 9.	Histidine	156-159	ribonuclease A family member 1, pancreatic	Homo sapiens	221-229
23288-12	1977	The S-protein is less stable to acid than RNase-A since the former, but not the latter, shows evidence of reversible denaturation at pH 3 and 26 degrees C. His-48 in S-protein titrates normally and has a lower pK than in RN-ase-A probably because of the absence of Asp-14, which in RN-ase-A forms a a hydrogen bond with His-48 and causes it to be inaccessible to solvent, at pH values below 9.	Histidine	156-159	ribonuclease A family member 1, pancreatic	Homo sapiens	282-290
117688-1	1979	The hypothesis that N-terminal histidine peptides might act as inhibitors to histidine decarboxylase was investigated.	Histidine	31-40	histidine decarboxylase	Homo sapiens	77-100
15493255-5	1989	These results suggest a similar binding site on human IgG for SPA and the HSV-1 Fc receptor with involvement of the amino acid residues Tyr and His but not Lys.	Histidine	144-147	surfactant protein A1	Homo sapiens	62-65
117688-6	1979	Histidine decarboxylase exclusively was inhibited by N-terminal histidine peptides.	Histidine	64-73	histidine decarboxylase	Homo sapiens	0-23
117688-10	1979	It is concluded that small peptides with histidine as the N-terminal amino acid might act as specific inhibitors for mammalian histidine decarboxylase.	Histidine	41-50	histidine decarboxylase	Homo sapiens	127-150
176880-2	1975	The dynamics of the complex formation between pyridoxal 5"-phosphate (PLP) and histidine in the presence of bacterial histidine decarboxylase was examined.	Histidine	79-88	histidine decarboxylase	Homo sapiens	118-141
3197838-4	1988	Like human angiogenin, the bovine protein is also homologous to bovine pancreatic RNase A (34% identity) and the three major active site residues known to be involved in the catalytic process, His-14, Lys-41 and His-115, are conserved.	Histidine	193-196	angiogenin	Homo sapiens	11-21
169122-8	1975	We conclude that after binding to receptors on GH3 cells, TRH is slowly metabolized to its constituent amino acids, and the products [2,3-3H]proline or [14C]histidine are incorporated into newly synthesized proteins.	Histidine	157-166	thyrotropin releasing hormone	Rattus norvegicus	58-61
238843-8	1975	In the presence of phosphate, titration curves for the H-2 proton resonances of histidine-12 and histidine-119 of methylated RNase-A indicate binding of phosphate at the active site, but these curves continue to show deviations from the titration behaviour of native RNase-A.	Histidine	97-106	ribonuclease A family member 1, pancreatic	Homo sapiens	125-132
381308-8	1979	Both proteinase B inhibitors have threonine as the NH2-terminal residue and -Val-His-Thr-Asn-COO- as the COOH-terminal sequence.	Histidine	81-84	proteinase B	Saccharomyces cerevisiae S288C	5-17
385447-1	1979	The his1 gene in Saccharomyces cerevisiae codes for phosphoribosyl transferase, an allosteric enzyme that catalyzes the initial step in histidine biosynthesis.	Histidine	136-145	ATP phosphoribosyltransferase	Saccharomyces cerevisiae S288C	4-8
385447-2	1979	Mutants that specifically alter the feedback regulatory function were isolated by selecting his1 prototrophic revertants that overproduce and excrete histidine.	Histidine	150-159	ATP phosphoribosyltransferase	Saccharomyces cerevisiae S288C	92-96
238843-8	1975	In the presence of phosphate, titration curves for the H-2 proton resonances of histidine-12 and histidine-119 of methylated RNase-A indicate binding of phosphate at the active site, but these curves continue to show deviations from the titration behaviour of native RNase-A.	Histidine	97-106	ribonuclease A family member 1, pancreatic	Homo sapiens	267-274
3197838-4	1988	Like human angiogenin, the bovine protein is also homologous to bovine pancreatic RNase A (34% identity) and the three major active site residues known to be involved in the catalytic process, His-14, Lys-41 and His-115, are conserved.	Histidine	212-215	angiogenin	Homo sapiens	11-21
4694729-2	1973	The histidine loop of human plasmin: light (B) chain active center histidine sequence.	Histidine	4-13	plasminogen	Homo sapiens	28-35
4694729-2	1973	The histidine loop of human plasmin: light (B) chain active center histidine sequence.	Histidine	67-76	plasminogen	Homo sapiens	28-35
3141237-1	1988	Brain and spinal sites of action of the stable thyrotropin-releasing hormone (TRH) analogue, RX 77368 [pGlu-His-(3,3"-dimethyl)-Pro-NH2], for stimulation of gastric acid secretion have been investigated in urethane-anesthetized rats with gastric fistula.	Histidine	108-111	thyrotropin releasing hormone	Rattus norvegicus	78-81
4621760-0	1972	On the role of the histidine moiety in the structure of the thyrotropin-releasing hormone.	Histidine	19-28	thyrotropin releasing hormone	Homo sapiens	60-89
107159-2	1979	An extract of porcine brain acetone powder incubated with thyrotropin-releasing hormone (TRH; pGlu-His-ProNH2) produces acid TRH (pGlu-His-Pro), histidine, and prolineamide.	Histidine	145-154	thyrotropin releasing hormone	Homo sapiens	58-87
107159-2	1979	An extract of porcine brain acetone powder incubated with thyrotropin-releasing hormone (TRH; pGlu-His-ProNH2) produces acid TRH (pGlu-His-Pro), histidine, and prolineamide.	Histidine	145-154	thyrotropin releasing hormone	Homo sapiens	89-92
2460872-1	1988	The peptide p89-101 (Val-His-Phe-Phe-Lys-Asn-Ile-Val-Thr-Pro-Arg-Thr-Pro) of myelin basic protein is encephalitogenic in mice expressing H-2q and H-2s antigens.	Histidine	25-28	inner membrane protein, mitochondrial	Mus musculus	12-15
365679-1	1978	The his1 gene (chromosome V) of Saccharomyces cerevisiae specifies phosphoribosyl transferase (E.C.2.4.2.17), the first enzyme of histidine biosynthesis.	Histidine	130-139	ATP phosphoribosyltransferase	Saccharomyces cerevisiae S288C	4-8
30487-5	1978	Of the amino acids examined it is concluded that only the histidine residues of cow kappa-casein are important for the hydrolytic action of chymosin and, furthermore, the treatment with diethyl pyrocarbonate suggests that only one of the three histidines plays an essential role.	Histidine	58-67	chymosin	Bos taurus	140-148
5001098-0	1971	[The significance of histidines in "thyrotropin-releasing" hormone (TRH)].	Histidine	21-31	thyrotropin releasing hormone	Homo sapiens	35-66
5001098-0	1971	[The significance of histidines in "thyrotropin-releasing" hormone (TRH)].	Histidine	21-31	thyrotropin releasing hormone	Homo sapiens	68-71
11947199-0	1969	Histidine residues at the active site of aminopeptidase M modifications by diazonium-1-h-tetrazole (dht).	Histidine	0-9	alanyl aminopeptidase, membrane	Homo sapiens	41-57
2460872-1	1988	The peptide p89-101 (Val-His-Phe-Phe-Lys-Asn-Ile-Val-Thr-Pro-Arg-Thr-Pro) of myelin basic protein is encephalitogenic in mice expressing H-2q and H-2s antigens.	Histidine	25-28	myelin basic protein	Mus musculus	77-97
3186740-0	1988	Ligand binding to synthetic mutant myoglobin (His-E7----Gly): role of the distal histidine.	Histidine	81-90	myoglobin	Physeter catodon	35-44
207308-2	1978	3-SLHis-105-RNase A is an active derivative of ribonuclease A (RNase A) spin-labeled at the 3 position of the imidazole ring of histidine-105.	Histidine	128-137	ribonuclease A family member 1, pancreatic	Homo sapiens	12-19
207308-2	1978	3-SLHis-105-RNase A is an active derivative of ribonuclease A (RNase A) spin-labeled at the 3 position of the imidazole ring of histidine-105.	Histidine	128-137	ribonuclease A family member 1, pancreatic	Homo sapiens	47-61
207308-2	1978	3-SLHis-105-RNase A is an active derivative of ribonuclease A (RNase A) spin-labeled at the 3 position of the imidazole ring of histidine-105.	Histidine	128-137	ribonuclease A family member 1, pancreatic	Homo sapiens	63-70
207308-4	1978	The results of these experiments indicate that the spin-label attached to histidine-105 of RNase A is sensitive to modifications affecting the conformational integrity of the molecule and to the reconstituting effects of various active-center ligands.	Histidine	74-83	ribonuclease A family member 1, pancreatic	Homo sapiens	91-98
14903117-0	1952	Effect of ACTH on incorporation of labeled-histidine into tissue proteins in male adult mice.	Histidine	42-52	pro-opiomelanocortin-alpha	Mus musculus	10-14
3186740-2	1988	The synthesis and high-level expression of a sperm-whale myoglobin gene in Escherichia coli permits the efficient substitution of the distal histidine through site-directed mutagenesis.	Histidine	141-150	myoglobin	Physeter catodon	57-66
3126807-10	1987	We propose a revised reaction mechanism in which two histidine residues play a major role, as they do in the case of RNase A.	Histidine	53-62	ribonuclease A family member 1, pancreatic	Homo sapiens	117-124
34046594-2	2021	Histidine methylation has recently attracted attention through the discovery of the human histidine methyltransferase enzymes SETD3 and METTL9.	Histidine	0-9	SET domain containing 3, actin histidine methyltransferase	Homo sapiens	126-131
34046594-2	2021	Histidine methylation has recently attracted attention through the discovery of the human histidine methyltransferase enzymes SETD3 and METTL9.	Histidine	90-99	SET domain containing 3, actin histidine methyltransferase	Homo sapiens	126-131
3122207-0	1987	Ribonucleolytic activity of angiogenin: essential histidine, lysine, and arginine residues.	Histidine	50-59	angiogenin	Homo sapiens	28-38
34038814-0	2021	Histidine dipeptides are key regulators of excitation-contraction coupling in cardiac muscle: Evidence from a novel CARNS1 knockout rat model.	Histidine	0-9	carnosine synthase 1	Rattus norvegicus	116-122
34022193-10	2021	Preincubation of chicken albumin with 1 mM the histidine modifying agents, 100 muM N-bromosuccinimide (NBS) and Zn(II), inhibited its Cu(II)-dependent R(+)-HDCPase activity, where as other mM aminoacids modifiers had no inhibitory effects.	Histidine	47-56	albumin	Gallus gallus	25-32
856608-5	1977	Histidine loadings however produced a marked increase in histidine decarboxylase activity of the glandular stomach and a simultaneous elevation in the serum histamine concentrations.	Histidine	0-9	histidine decarboxylase	Rattus norvegicus	57-80
393-2	1975	Hemoglobin Deer Lodge is an abnormal human hemoglobin with arginine substituted for histidine at the beta 2 position.	Histidine	84-93	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	101-107
3122207-2	1987	Reagents specific for histidine, lysine, and arginine markedly decrease the ribonucleolytic activity of angiogenin, much as has been observed for RNase A.	Histidine	22-31	angiogenin	Homo sapiens	104-114
3122207-2	1987	Reagents specific for histidine, lysine, and arginine markedly decrease the ribonucleolytic activity of angiogenin, much as has been observed for RNase A.	Histidine	22-31	ribonuclease A family member 1, pancreatic	Homo sapiens	146-153
33239752-1	2021	PURPOSE: In this study we investigate the disease etiology in 12 patients with de novo variants in FAR1 all resulting in an amino acid change at position 480 (p.Arg480Cys/His/Leu).	Histidine	171-174	fatty acyl-CoA reductase 1	Homo sapiens	99-103
3122207-5	1987	From the point of view of reactivity, the histidine and lysine residues in angiogenin are severalfold less susceptible to modification than those in RNase A.	Histidine	42-51	angiogenin	Homo sapiens	75-85
3122207-7	1987	Considering specificity, bromoacetate inactivates angiogenin at pH 5.5 by modifying 1.5 histidines, but lysine and arginine reagents are less specific.	Histidine	88-98	angiogenin	Homo sapiens	50-60
3120012-2	1987	This hypothesis is strengthened by the observation that TRH is hydrolysed at the pyroGlu-His bond by a particulate enzyme located in the synaptosomal and adenohypophyseal plasma membrane.	Histidine	89-92	thyrotropin releasing hormone	Rattus norvegicus	56-59
33791245-7	2021	The relative abundances of multiple butyrate producing microbes are reduced in patients with high-grade thyroid nodules and the relative abundances of L-histidine metabolism pathways are associated with thyrotropin-releasing hormone.	Histidine	151-162	thyrotropin releasing hormone	Homo sapiens	203-232
1220546-0	1975	Proceedings: The kinetics of complex formation between histidine and pyridoxal-5-phosphate in the presence of bacterial histidine decarboxylase.	Histidine	55-64	histidine decarboxylase	Homo sapiens	120-143
821746-4	1975	Of the TRH analogues tested, only two (Ser-His-Pro-NH2, Thr-His-Pro-NH2) had potent reactivity to anti-TRH serum in large dose of 100 ng/tube.	Histidine	43-46	thyrotropin releasing hormone	Homo sapiens	103-106
3315362-6	1987	On the basis of these parameters it is suggested that this group is a histidine residue on the surface of the insulin receptor.	Histidine	70-79	insulin receptor	Rattus norvegicus	110-126
238843-8	1975	In the presence of phosphate, titration curves for the H-2 proton resonances of histidine-12 and histidine-119 of methylated RNase-A indicate binding of phosphate at the active site, but these curves continue to show deviations from the titration behaviour of native RNase-A.	Histidine	80-89	ribonuclease A family member 1, pancreatic	Homo sapiens	267-274
235021-0	1975	Inhibition of histidine, decarboxylation in vivo by 2-hydroxy-5-carbomethoxybenzyloxyamine, a new, potent inhibitor of histidine decarboxylase.	Histidine	14-23	histidine decarboxylase	Rattus norvegicus	119-142
33578665-8	2021	Attachment of the antigens to the ELISA surface using a layer of anti-histidine antibodies gave equivalent resolution for both S-RBDN318-V510 and the full-length spike protein.	Histidine	70-79	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	162-167
3118225-6	1987	It is proposed that 29,247 molecular weight TRH prohormone, prepro TRH, which contains 5 copies of TRH sequence, can be processed to yield cyclo(His-Pro).	Histidine	145-148	thyrotropin releasing hormone	Homo sapiens	44-47
33189720-4	2021	Exchange activity of arginine and histidine/arginine, as observed for Ypq2 of S. cerevisiae, was also detected in the vesicles expressing stm1+.	Histidine	34-43	Ypq2p	Saccharomyces cerevisiae S288C	70-74
3118225-6	1987	It is proposed that 29,247 molecular weight TRH prohormone, prepro TRH, which contains 5 copies of TRH sequence, can be processed to yield cyclo(His-Pro).	Histidine	145-148	thyrotropin releasing hormone	Homo sapiens	67-70
33751430-1	2021	Here we describe a protocol for a one-step purification of a soluble form of human FAD synthase (isoform 2; hFADS2), overexpressed as a 6-His-tagged fusion protein in Escherichia coli, with a yield of about 15 mg from 1 L of transformed bacterial culture.Following a desalting procedure, the protein is obtained in its FAD-bound form (about 0.8 molecules of FAD per 1 protein monomer).	Histidine	138-141	flavin adenine dinucleotide synthetase 1	Homo sapiens	83-95
3118225-6	1987	It is proposed that 29,247 molecular weight TRH prohormone, prepro TRH, which contains 5 copies of TRH sequence, can be processed to yield cyclo(His-Pro).	Histidine	145-148	thyrotropin releasing hormone	Homo sapiens	67-70
32978260-2	2020	alphaM protease inhibitors use theirs to conjugate proteases and preferentially react with primary amines (e.g. on lysine side chains), whereas those of alphaM complement components C3 and C4B have an increased hydroxyl reactivity that is conveyed by a conserved histidine residue and allows conjugation to cell surface glycans.	Histidine	263-272	complement C4B (Chido blood group)	Homo sapiens	189-192
4338667-0	1972	Protein-bound phosphoryl histidine: a probable intermediate in the microsomal glucose-6-phosphatase-inorganic pyrophosphatase reaction.	Histidine	25-34	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	78-99
3118225-7	1987	Thus, both TRH and cyclo(His-Pro) share a common precursor, prepro[TRH/Cyclo(His-Pro)].	Histidine	25-28	thyrotropin releasing hormone	Homo sapiens	67-70
32980952-1	2020	Cationic amino acid transporter 1 (Cat-1 alias Slc7a1) is a Na+-independent carrier system involved in transport and absorption of the cationic amino acids lysine, arginine, histidine, and ornithine and has also been shown to be indispensable in a large variety of biological processes.	Histidine	174-183	solute carrier family 7 member 1a	Danio rerio	47-53
3607070-1	1987	We reported previously that the distal(E7) histidine is replaced by glutamine in myoglobin from the shark, Galeorhinus japonicus.	Histidine	43-52	myoglobin	Physeter catodon	81-90
33091731-5	2020	In the case of Zn(II)-alloferon 1 species, a histamine-like binding mode is observed (N-terminal amine and imidazole of His-1) and the coordination sphere is completed with the imidazole nitrogens of His-6 and His-9; His-12 is not involved in binding.	Histidine	200-203	viral integration site 1	Homo sapiens	120-125
33091731-5	2020	In the case of Zn(II)-alloferon 1 species, a histamine-like binding mode is observed (N-terminal amine and imidazole of His-1) and the coordination sphere is completed with the imidazole nitrogens of His-6 and His-9; His-12 is not involved in binding.	Histidine	200-203	viral integration site 1	Homo sapiens	120-125
5403998-0	1969	Production of  14 CO 2  from histidine- 14 COOH by N-(2"-carbomethoxy)cyclopentylidene, cyanoacethydrazide and rat pyloric histidine decarboxylase.	Histidine	29-38	histidine decarboxylase	Rattus norvegicus	123-146
3607070-3	1987	The myoglobin is composed of 148 residues, is acetylated at the N-terminus, and contains the distal(E7) histidine at position 59.	Histidine	104-113	myoglobin	Physeter catodon	4-13
3607070-8	1987	On the other hand, the pH dependence of G. japonicus myoglobin, which has the distal glutamine in the place of histidine, was quite different from those of sperm-whale and H. japonicus myoglobins.	Histidine	111-120	myoglobin	Physeter catodon	53-62
3109876-1	1987	The sequence of rat hypothalamic pro-TRH, deduced by sequencing of cDNA, contains five copies of the TRH progenitor sequence Gln-His-Pro-Gly flanked by paired basic amino acid sequences.	Histidine	129-132	thyrotropin releasing hormone	Rattus norvegicus	33-40
5702975-0	1968	Growth hormone effects on histidine incorporation into protein by adiposed tissue from hypophysectomized rats.	Histidine	26-35	gonadotropin releasing hormone receptor	Rattus norvegicus	0-14
33554371-8	2021	In addition, there was an increase in the activity of superoxide dismutase, catalase, peroxidase, and ascorbate peroxidase antioxidant enzymes in leaves due to HI, regardless of FC.	Histidine	160-162	catalase-3	Glycine max	76-84
33154747-3	2020	Examination of these SNPs led to the functional testing of rs1131769, a non-synonymous SNP in TMEM173 causing an Arg-to-His change at position 232 in the STING protein-a major regulator of innate immune responses to viral infections.	Histidine	120-123	stimulator of interferon response cGAMP interactor 1	Homo sapiens	94-101
33154747-3	2020	Examination of these SNPs led to the functional testing of rs1131769, a non-synonymous SNP in TMEM173 causing an Arg-to-His change at position 232 in the STING protein-a major regulator of innate immune responses to viral infections.	Histidine	120-123	stimulator of interferon response cGAMP interactor 1	Homo sapiens	154-159
3109876-1	1987	The sequence of rat hypothalamic pro-TRH, deduced by sequencing of cDNA, contains five copies of the TRH progenitor sequence Gln-His-Pro-Gly flanked by paired basic amino acid sequences.	Histidine	129-132	thyrotropin releasing hormone	Rattus norvegicus	37-40
3473473-2	1987	The TRH precursor fragment H-Lys-Arg-Gln-His-Pro-Gly-Lys-Arg-OH and the D-glutaminyl stereoisomer of H-Gln-Tyr-Ala-OH did not react under the same conditions.	Histidine	41-44	thyrotropin releasing hormone	Homo sapiens	4-7
32902579-3	2020	When we replaced valine with histidine at position 116 in the external vestibule of hHV1, current was potently inhibited by externally applied Zn2+ in a construct lacking the two His that bind Zn2+ in WT channels.	Histidine	179-182	hydrogen voltage gated channel 1	Homo sapiens	84-88
32860079-11	2020	In summary, our studies indicate that NME1 and NME2 are involved in TGF-beta1-induced HSC activation and CCl4-induced liver fibrosis, which may be mediated by histidine phosphorylation.	Histidine	159-168	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	38-42
34032009-0	2021	beta-Actin Peptide-Based Inhibitors of Histidine Methyltransferase SETD3.	Histidine	39-48	SET domain containing 3, actin histidine methyltransferase	Homo sapiens	67-72
34032009-1	2021	SETD3 was recently identified as the histidine methyltransferase responsible for N 3 -methylation of His73 of beta-actin in humans.	Histidine	37-46	SET domain containing 3, actin histidine methyltransferase	Homo sapiens	0-5
3814749-3	1986	A salt bridge of this type (Glu- 9-His+ 12) was postulated previously to stabilize, to a great extent, the alpha-helical conformation of isolated N-terminal fragments of RNase A: C-peptide and S-peptide (A. Bierzynski, P.S.	Histidine	35-38	ribonuclease A family member 1, pancreatic	Homo sapiens	170-177
33582214-9	2021	Inactive FSHalpha and FSHbeta subunits expressed from GMECs assembled into rhFSH as analyzed by His-tag pull down assay.	Histidine	96-99	glycoprotein hormones, alpha polypeptide	Homo sapiens	9-17
33617675-2	2021	However, the motifs with histidine in the first three N-terminal positions (His1 , His2 , and His3 ) show unique Cu(II)-binding properties, such as availability from the surface of the protein, high flexibility, and high Cu(II) exchangeability with other ligands.	Histidine	25-34	viral integration site 1	Homo sapiens	76-80
33625485-3	2021	Primary human umbilical vein endothelial cells (HUVECs) treated with a recombinant histidine-tagged sPRR (sPRR-His) exhibited IkappaBalpha degradation concurrent with NF-kappaB p65 activation.	Histidine	83-92	RELA proto-oncogene, NF-kB subunit	Homo sapiens	167-180
32805585-5	2020	Moreover, the MT-nucleation centers significantly increased in numbers, and gamma-tubulin was pulled-down in a binding assay when co-expressed with histidine-tagged-mu2 and muNS.	Histidine	148-157	adaptor related protein complex 1 subunit mu 2	Homo sapiens	165-168
3491633-5	1986	For pHi values above approximately 7.0, the observed buffer power was greater than that expected from the values in the literature for the histidine content of intracellular proteins, carnosine and inorganic phosphate in the sarcoplasm.	Histidine	139-148	glucose-6-phosphate isomerase	Homo sapiens	4-7
32475637-2	2020	Although translational control during UPR has not been extensively investigated in S. cerevisiae, Hac1-mediated production of long transcripts containing uORFs was shown to repress the translation of histidine triad nucleotide-binding 1 (HNT1) mRNA.	Histidine	200-209	transcription factor HAC1	Saccharomyces cerevisiae S288C	98-102
33667085-8	2021	The non-enzymatic methylations of imidazole and methionine by TMS+, benchmarks for the methylation of histidine and methionine residues by SETD3, exhibit k25 values of 3.3 x 10-9 and 1.2 x 10-9 M-1 s-1, respectively.	Histidine	102-111	SET domain containing 3, actin histidine methyltransferase	Homo sapiens	139-144
33625414-8	2021	The interaction of the complexes with human transferrin (hTf) proteins was studied through molecular docking calculations, suggesting favorable binding through histidine residues and possible internalization into cancer cells via TfR-mediated endocytosis.	Histidine	160-169	transferrin receptor	Homo sapiens	230-233
3741844-4	1986	The nondegeneracy of the dxz and dyz orbitals in Mb(III)NO and Hbh(III)NO is attributed to the influence of the distal histidine.	Histidine	119-128	hemoglobin subunit alpha 1	Homo sapiens	63-66
32642015-3	2020	Diagnosis was identified by whole-exome sequencing identifying mutations in a conserved histidine-rich motif within the gene Atrophin-1.	Histidine	88-97	atrophin 1	Homo sapiens	125-135
3527256-1	1986	A photochemically induced dynamic nuclear polarization (photo-CIDNP) study of yeast and horse muscle phosphoglycerate kinase with flavin dyes was undertaken to identify the histidine, tryptophan, and tyrosine resonances in the aromatic region of the simplified 1H NMR spectra of these enzymes and to investigate the effect of substrates on the resonances observable by CIDNP.	Histidine	173-182	phosphoglycerate kinase	Saccharomyces cerevisiae S288C	101-124
32661472-1	2020	Endometrial carcinoma is the most common malignant tumors of the reproductive system, and fragile histidine triad (FHIT) plays an important role in multiple tumors.	Histidine	98-107	fragile histidine triad diadenosine triphosphatase	Homo sapiens	115-119
3718921-6	1986	This may result from extensive ion-pair interactions involving positively charged histidines and negatively charged phosphoserines, which are prevalent in the phosvitin sequence.	Histidine	82-92	casein kinase 2 beta	Homo sapiens	159-168
32392889-5	2020	NME1 and NME2 have been shown to possess histidine (His) kinase activity.	Histidine	41-50	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	0-4
32392889-8	2020	Our demonstration of NME1 histidine phosphorylation in neuroblastoma and of the potential role of NME1 in neuroblastoma cell migration and differentiation suggest a functional role for NME1 in neuroblastoma pathogenesis and open the possibility of identifying new therapeutic targets and developing novel approaches to neuroblastoma therapy.	Histidine	26-35	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	21-25
33505099-1	2021	Histamine is a degradation product of the bacterial decarboxylation of the amino acid histidine; such activity is determined by histidine decarboxylase encoded by a gene cluster, carried by some Gram-positive bacteria, that includes the hdcA gene.	Histidine	86-95	histidine decarboxylase	Homo sapiens	128-151
3530729-5	1986	Chicken LHRH-II, where tyrosine is replaced for histidine, has a lower affinity (0.3X) than that of mammalian LHRH.	Histidine	48-57	gonadotropin releasing hormone 1	Homo sapiens	8-12
33581700-10	2021	Furthermore, molecular modelling with a newly created homology model of human hemopexin suggested a possible recruiting mechanism by which heme could consecutively bind several histidine residues on its way into the binding pocket.	Histidine	177-186	hemopexin	Homo sapiens	78-87
3530729-5	1986	Chicken LHRH-II, where tyrosine is replaced for histidine, has a lower affinity (0.3X) than that of mammalian LHRH.	Histidine	48-57	gonadotropin releasing hormone 1	Homo sapiens	110-114
32125789-3	2020	B-PDPN possesses the characteristics of an acid-activated histidine to promote cellular uptake, a redox-sensitive poly(ethylene glycol) (PEG) layer to actualize endosomal escape and telomerase inhibitor release, and an acid sensitive chemical bond to facilitate chemotherapeutic drug release.	Histidine	58-67	podoplanin	Homo sapiens	2-6
3907706-1	1985	The histidine-containing phosphocarrier protein (HPr) of the phosphoenolpyruvate:sugar phosphotransferase system, when phosphorylated, contains a 1-phosphohistidinyl (1-P-histidinyl) residue (His-15).	Histidine	192-195	haptoglobin-related protein	Homo sapiens	4-47
32183428-11	2020	FAM84B conserves H23 and H35 but not C113 with both histidine residues residing within a highly conserved motif that FAM84B shares with HRASLS1-5.	Histidine	52-61	LRAT domain containing 1	Mus musculus	0-6
32127621-0	2020	Author Correction: MIG1 as a positive regulator for the histidine biosynthesis pathway and as a global regulator in thermotolerant yeast Kluyveromyces marxianus.	Histidine	56-65	transcription factor MIG1	Saccharomyces cerevisiae S288C	19-23
33167279-6	2021	The immobilized peptide would be cleavaged by proteinase K, then the His-tag residue part will leave the surface of Au film, resulting less His-tag could bind to Ni2+ and a small SPR signal would be record.	Histidine	69-72	sepiapterin reductase	Homo sapiens	179-182
3907706-1	1985	The histidine-containing phosphocarrier protein (HPr) of the phosphoenolpyruvate:sugar phosphotransferase system, when phosphorylated, contains a 1-phosphohistidinyl (1-P-histidinyl) residue (His-15).	Histidine	192-195	haptoglobin-related protein	Homo sapiens	49-52
33157163-0	2021	The methyltransferase SETD3-mediated histidine methylation: Biological functions and potential implications in cancers.	Histidine	37-46	SET domain containing 3, actin histidine methyltransferase	Homo sapiens	22-27
3935636-3	1985	His-Pro diketopiperazine, a biologically active metabolite of TRH consisting of a cyclic dipeptide of histidine and proline, also was measured by specific RIA.	Histidine	102-111	thyrotropin releasing hormone	Homo sapiens	62-65
33157163-2	2021	Recently, SETD3 was found as the first and so-far the only known metazoan histidine methyltransferase that catalyzes actin histidine 73 (His73) methylation, a pervasive modification which was discovered more than 50 years ago.	Histidine	74-83	SET domain containing 3, actin histidine methyltransferase	Homo sapiens	10-15
33157163-4	2021	We particularly highlight potential pathological relevance of SETD3 in human cancers and raise some questions to promote discussion about this novel histidine methyltransferase.	Histidine	149-158	SET domain containing 3, actin histidine methyltransferase	Homo sapiens	62-67
31911441-0	2020	An engineered variant of SETD3 methyltransferase alters target specificity from histidine to lysine methylation.	Histidine	80-89	SET domain containing 3, actin histidine methyltransferase	Homo sapiens	25-30
31911441-3	2020	In the SETD3 active site, Asn255 engages in a unique hydrogen-bonding interaction with the target histidine of actin that likely contributes to its >1300-fold greater catalytic efficiency (k cat/Km ) on histidine than on lysine.	Histidine	98-107	SET domain containing 3, actin histidine methyltransferase	Homo sapiens	7-12
31911441-3	2020	In the SETD3 active site, Asn255 engages in a unique hydrogen-bonding interaction with the target histidine of actin that likely contributes to its >1300-fold greater catalytic efficiency (k cat/Km ) on histidine than on lysine.	Histidine	203-212	SET domain containing 3, actin histidine methyltransferase	Homo sapiens	7-12
31911441-4	2020	Here, we engineered active-site variants to switch the SETD3 target specificity from histidine to lysine.	Histidine	85-94	SET domain containing 3, actin histidine methyltransferase	Homo sapiens	55-60
31911441-6	2020	The doubly substituted SETD3 variant exhibited a 13-fold preference for lysine over histidine.	Histidine	84-93	SET domain containing 3, actin histidine methyltransferase	Homo sapiens	23-28
33545834-4	2021	Role of several amino acids has been investigated but the role of L-his has been rarely investigated under physiological conditions even though it is a part of HA inhibitor proteins, like albumin, amelogenin, and histidine-rich proteins.	Histidine	66-71	albumin	Mus musculus	188-195
3935636-5	1985	A hydrophobic TRH-homologous peptide with the amino acid composition (Glu,X,Y,Pro), where X and Y are neutral, nonaromatic amino acids, increased 8-fold during 16 hours of incubation at 4 C. This TRH-homologous peptide is not derived from TRH because it lacks the histidine is not derived from TRH because it lacks the histidine residue.	Histidine	264-273	thyrotropin releasing hormone	Homo sapiens	14-17
31625059-5	2020	In this study, a 6 x His-tag coupled with a thrombin cleavage site was fused to the C-terminus of cystatin C, and the protein was well expressed in Escherichia coli after optimization.	Histidine	21-24	cystatin C	Homo sapiens	98-108
3935636-5	1985	A hydrophobic TRH-homologous peptide with the amino acid composition (Glu,X,Y,Pro), where X and Y are neutral, nonaromatic amino acids, increased 8-fold during 16 hours of incubation at 4 C. This TRH-homologous peptide is not derived from TRH because it lacks the histidine is not derived from TRH because it lacks the histidine residue.	Histidine	264-273	thyrotropin releasing hormone	Homo sapiens	196-199
3935636-5	1985	A hydrophobic TRH-homologous peptide with the amino acid composition (Glu,X,Y,Pro), where X and Y are neutral, nonaromatic amino acids, increased 8-fold during 16 hours of incubation at 4 C. This TRH-homologous peptide is not derived from TRH because it lacks the histidine is not derived from TRH because it lacks the histidine residue.	Histidine	264-273	thyrotropin releasing hormone	Homo sapiens	196-199
3935636-5	1985	A hydrophobic TRH-homologous peptide with the amino acid composition (Glu,X,Y,Pro), where X and Y are neutral, nonaromatic amino acids, increased 8-fold during 16 hours of incubation at 4 C. This TRH-homologous peptide is not derived from TRH because it lacks the histidine is not derived from TRH because it lacks the histidine residue.	Histidine	264-273	thyrotropin releasing hormone	Homo sapiens	196-199
3935636-5	1985	A hydrophobic TRH-homologous peptide with the amino acid composition (Glu,X,Y,Pro), where X and Y are neutral, nonaromatic amino acids, increased 8-fold during 16 hours of incubation at 4 C. This TRH-homologous peptide is not derived from TRH because it lacks the histidine is not derived from TRH because it lacks the histidine residue.	Histidine	319-328	thyrotropin releasing hormone	Homo sapiens	14-17
31919279-3	2020	Bioinformatic analyses indicated that PD-1H has a very long Ig variable region (IgV)-like domain and extraordinarily high histidine content, suggesting that unique structural features may contribute to coinhibitory mechanisms.	Histidine	122-131	V-set immunoregulatory receptor	Homo sapiens	38-43
3935636-5	1985	A hydrophobic TRH-homologous peptide with the amino acid composition (Glu,X,Y,Pro), where X and Y are neutral, nonaromatic amino acids, increased 8-fold during 16 hours of incubation at 4 C. This TRH-homologous peptide is not derived from TRH because it lacks the histidine is not derived from TRH because it lacks the histidine residue.	Histidine	319-328	thyrotropin releasing hormone	Homo sapiens	196-199
33115767-10	2020	Computational analysis of HSD17B4 His540Arg showed the change to likely impact dimerization based on structural insights, with the histidine conserved and selected throughout all 223 species assessed for this amino acid.	Histidine	131-140	hydroxysteroid 17-beta dehydrogenase 4	Homo sapiens	26-33
3935636-5	1985	A hydrophobic TRH-homologous peptide with the amino acid composition (Glu,X,Y,Pro), where X and Y are neutral, nonaromatic amino acids, increased 8-fold during 16 hours of incubation at 4 C. This TRH-homologous peptide is not derived from TRH because it lacks the histidine is not derived from TRH because it lacks the histidine residue.	Histidine	319-328	thyrotropin releasing hormone	Homo sapiens	196-199
3935636-5	1985	A hydrophobic TRH-homologous peptide with the amino acid composition (Glu,X,Y,Pro), where X and Y are neutral, nonaromatic amino acids, increased 8-fold during 16 hours of incubation at 4 C. This TRH-homologous peptide is not derived from TRH because it lacks the histidine is not derived from TRH because it lacks the histidine residue.	Histidine	319-328	thyrotropin releasing hormone	Homo sapiens	196-199
3935636-6	1985	A 3- to 23-fold increase in His-Pro diketopiperazine levels occurred after 4 hours at 37 C. This was not due primarily to enzymatic removal of the pyroglutamyl residue from TRH by pyroglutamate aminopeptidase, since about 1 hour after ejaculation the initial His-Pro diketopiperazine levels were 9.7 +/- 5.1 micrograms/ml, or approximately 1000-fold greater than the corresponding levels of seminal TRH.	Histidine	28-31	thyrotropin releasing hormone	Homo sapiens	399-402
2861789-5	1985	We have proposed that the mixed-function oxidation system (the cytochrome P-450 system) produces Fe(II) and H2O2 which react at the metal binding site on the glutamine synthetase to generate an activated oxygen species which oxidizes a nearby susceptible histidine.	Histidine	255-264	cytochrome P-450	Oryctolagus cuniculus	63-79
33226214-3	2020	Previously, we found that the Sec-devoid His-rich motif of selenoprotein P (Selenop-H) suppressed metal-induced aggregation and neurotoxicities of both Abeta and tau in vitro.	Histidine	41-44	eukaryotic elongation factor, selenocysteine-tRNA-specific	Mus musculus	30-33
31210592-5	2019	RESULTS: Our results showed that his-mir-335 was a critical regulatory of homeobox A gene family.	Histidine	33-36	microRNA 335	Homo sapiens	37-44
3928667-3	1985	These results suggest that hemopexin is composed of two domains that are connected by an exposed histidine-rich hinge-like region in apohemopexin which becomes inaccessible to trypsin in heme-saturated hemopexin.	Histidine	97-106	hemopexin	Homo sapiens	27-36
31687022-7	2019	We also performed bioinformatic analysis to evaluate the impact of variants on MKRN3 protein structures, which showed that Ile357Met locates at the zinc-binding region (C3HC4 RING finger motif), while Glu380Lys is spatially extremely close to the C3HC4 RING finger, MKRN-specific Cys-His domain, and the third C3H1 zinc-finger motif region.	Histidine	284-287	makorin ring finger protein 3	Homo sapiens	79-84
32603918-6	2020	Myosin light chain (MYL1 and MYL3) showed high oxidative susceptibility owing to peptidyl methionine and proline oxidation as well as acetaldehyde adduct formation on lysine or histidine residues.	Histidine	177-186	myosin light chain 3	Homo sapiens	29-33
3928667-3	1985	These results suggest that hemopexin is composed of two domains that are connected by an exposed histidine-rich hinge-like region in apohemopexin which becomes inaccessible to trypsin in heme-saturated hemopexin.	Histidine	97-106	hemopexin	Homo sapiens	136-145
2859986-4	1985	The stimulatory actions of GH-releasing factor (GRF) and porcine heptacosapeptide with amino-terminal histidine and carboxy-terminal isoleucine amide (PHI) were mediated by high affinity VIP receptors because their effects were not additive with that of 10 nM VIP.	Histidine	102-111	growth hormone releasing hormone	Mus musculus	27-46
2859986-4	1985	The stimulatory actions of GH-releasing factor (GRF) and porcine heptacosapeptide with amino-terminal histidine and carboxy-terminal isoleucine amide (PHI) were mediated by high affinity VIP receptors because their effects were not additive with that of 10 nM VIP.	Histidine	102-111	growth hormone releasing hormone	Mus musculus	48-51
31569521-2	2019	Its lipid inhibition effects indicated that the synthetic peptide PP1 exhibits a good inhibitory effect against porcine pancreatic lipase (PL) (47.95%) at 200 mug/mL, which could be attributed to its hydrogen binding into catalytic sites of PL (Ser153, Asp177, and His 264) by docking analysis.	Histidine	265-268	protein phosphatase 1 catalytic subunit gamma	Mus musculus	66-69
4050131-8	1985	Pretreatment with alpha-fluoromethylhistidine (alpha FMH), a potent and specific inhibitor of histidine decarboxylase, produced a reduction in the effects of histidine.	Histidine	36-45	histidine decarboxylase	Rattus norvegicus	94-117
32720396-1	2020	INTRODUCTION: Permanent His bundle pacing (p-HBP) could be an alternative for traditional cardiac resynchronization therapy (CRT), but an important limitation is that p-HBP cannot always correct the left bundle branch block (LBBB).	Histidine	24-27	heme binding protein 1	Homo sapiens	45-48
33335661-4	2020	A salt bridge contact with Glu651 in IRE1alpha was then targeted to build in selectivity over BRaf which instead possesses a histidine in this position (His539).	Histidine	125-134	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	37-46
33000155-11	2020	Histidine can be decarboxylated to histamine by histidine decarboxylase.	Histidine	0-9	histidine decarboxylase	Homo sapiens	48-71
3893464-6	1985	The structural analysis showed that beta 2-Bern differs at only one position from beta 1: Arg-47 in beta 1 is substituted for His-47 in beta 2-Bern.	Histidine	126-129	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	36-42
32879443-6	2020	Moreover, the mutation of histidine 200 of JMJD8 (JMJD8-H200Q) disrupted its binding with AKT1 and increased interaction of SETDB1 and PDK1 with AKT1.	Histidine	26-35	jumonji domain containing 8	Homo sapiens	43-48
32879443-6	2020	Moreover, the mutation of histidine 200 of JMJD8 (JMJD8-H200Q) disrupted its binding with AKT1 and increased interaction of SETDB1 and PDK1 with AKT1.	Histidine	26-35	jumonji domain containing 8	Homo sapiens	50-55
3893464-6	1985	The structural analysis showed that beta 2-Bern differs at only one position from beta 1: Arg-47 in beta 1 is substituted for His-47 in beta 2-Bern.	Histidine	126-129	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	136-142
33029259-7	2020	Conclusions: Changes in Glu level measured by 1H-MRS were inversely correlated with those in EAAT2 and GluR2 protein levels following HI, and the results demonstrated that 1H-MRS can reflect the early changes of glutamatergic activity in vivo.	Histidine	134-136	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	103-108
3156581-4	1985	Histidine residues are the primary target for the sensitized photo-oxidation that inactivates lipoamide dehydrogenase and alcohol dehydrogenase.	Histidine	0-9	dihydrolipoamide dehydrogenase	Homo sapiens	94-117
32887365-0	2020	Histidine Residues Are Responsible for Bidirectional Effects of Zinc on Acid-Sensing Ion Channel 1a/3 Heteromeric Channels.	Histidine	0-9	acid-sensing (proton-gated) ion channel 3	Mus musculus	72-101
6480697-1	1984	A major event in the keratinization of epidermis is the production of the histidine-rich protein filaggrin (26,000 mol wt) from its high molecular weight (greater than 350,000) phosphorylated precursor (profilaggrin).	Histidine	74-83	filaggrin	Mus musculus	97-106
32887365-7	2020	Furthermore, we systematically mutated histidine residues in the extracellular domain of ASIC1a or ASIC3 and found that histidine residues 72 and 73 in both ASIC1a and ASIC3, and histidine residue 83 in the ASIC3 were responsible for bidirectional effects on heteromeric ASIC1a/3 channels by zinc.	Histidine	39-48	acid-sensing (proton-gated) ion channel 1	Mus musculus	89-95
32887365-7	2020	Furthermore, we systematically mutated histidine residues in the extracellular domain of ASIC1a or ASIC3 and found that histidine residues 72 and 73 in both ASIC1a and ASIC3, and histidine residue 83 in the ASIC3 were responsible for bidirectional effects on heteromeric ASIC1a/3 channels by zinc.	Histidine	39-48	acid-sensing (proton-gated) ion channel 3	Mus musculus	99-104
32887365-7	2020	Furthermore, we systematically mutated histidine residues in the extracellular domain of ASIC1a or ASIC3 and found that histidine residues 72 and 73 in both ASIC1a and ASIC3, and histidine residue 83 in the ASIC3 were responsible for bidirectional effects on heteromeric ASIC1a/3 channels by zinc.	Histidine	39-48	acid-sensing (proton-gated) ion channel 1	Mus musculus	157-163
32887365-7	2020	Furthermore, we systematically mutated histidine residues in the extracellular domain of ASIC1a or ASIC3 and found that histidine residues 72 and 73 in both ASIC1a and ASIC3, and histidine residue 83 in the ASIC3 were responsible for bidirectional effects on heteromeric ASIC1a/3 channels by zinc.	Histidine	39-48	acid-sensing (proton-gated) ion channel 3	Mus musculus	168-173
32887365-7	2020	Furthermore, we systematically mutated histidine residues in the extracellular domain of ASIC1a or ASIC3 and found that histidine residues 72 and 73 in both ASIC1a and ASIC3, and histidine residue 83 in the ASIC3 were responsible for bidirectional effects on heteromeric ASIC1a/3 channels by zinc.	Histidine	39-48	acid-sensing (proton-gated) ion channel 3	Mus musculus	168-173
32887365-7	2020	Furthermore, we systematically mutated histidine residues in the extracellular domain of ASIC1a or ASIC3 and found that histidine residues 72 and 73 in both ASIC1a and ASIC3, and histidine residue 83 in the ASIC3 were responsible for bidirectional effects on heteromeric ASIC1a/3 channels by zinc.	Histidine	120-129	acid-sensing (proton-gated) ion channel 1	Mus musculus	89-95
32887365-7	2020	Furthermore, we systematically mutated histidine residues in the extracellular domain of ASIC1a or ASIC3 and found that histidine residues 72 and 73 in both ASIC1a and ASIC3, and histidine residue 83 in the ASIC3 were responsible for bidirectional effects on heteromeric ASIC1a/3 channels by zinc.	Histidine	120-129	acid-sensing (proton-gated) ion channel 3	Mus musculus	99-104
32887365-7	2020	Furthermore, we systematically mutated histidine residues in the extracellular domain of ASIC1a or ASIC3 and found that histidine residues 72 and 73 in both ASIC1a and ASIC3, and histidine residue 83 in the ASIC3 were responsible for bidirectional effects on heteromeric ASIC1a/3 channels by zinc.	Histidine	120-129	acid-sensing (proton-gated) ion channel 1	Mus musculus	157-163
32887365-7	2020	Furthermore, we systematically mutated histidine residues in the extracellular domain of ASIC1a or ASIC3 and found that histidine residues 72 and 73 in both ASIC1a and ASIC3, and histidine residue 83 in the ASIC3 were responsible for bidirectional effects on heteromeric ASIC1a/3 channels by zinc.	Histidine	120-129	acid-sensing (proton-gated) ion channel 3	Mus musculus	168-173
6480697-1	1984	A major event in the keratinization of epidermis is the production of the histidine-rich protein filaggrin (26,000 mol wt) from its high molecular weight (greater than 350,000) phosphorylated precursor (profilaggrin).	Histidine	74-83	filaggrin	Mus musculus	203-215
32887365-7	2020	Furthermore, we systematically mutated histidine residues in the extracellular domain of ASIC1a or ASIC3 and found that histidine residues 72 and 73 in both ASIC1a and ASIC3, and histidine residue 83 in the ASIC3 were responsible for bidirectional effects on heteromeric ASIC1a/3 channels by zinc.	Histidine	120-129	acid-sensing (proton-gated) ion channel 3	Mus musculus	168-173
32887365-7	2020	Furthermore, we systematically mutated histidine residues in the extracellular domain of ASIC1a or ASIC3 and found that histidine residues 72 and 73 in both ASIC1a and ASIC3, and histidine residue 83 in the ASIC3 were responsible for bidirectional effects on heteromeric ASIC1a/3 channels by zinc.	Histidine	120-129	acid-sensing (proton-gated) ion channel 1	Mus musculus	89-95
32887365-7	2020	Furthermore, we systematically mutated histidine residues in the extracellular domain of ASIC1a or ASIC3 and found that histidine residues 72 and 73 in both ASIC1a and ASIC3, and histidine residue 83 in the ASIC3 were responsible for bidirectional effects on heteromeric ASIC1a/3 channels by zinc.	Histidine	120-129	acid-sensing (proton-gated) ion channel 3	Mus musculus	99-104
6712729-5	1984	L-Histidine, a substrate, protected HDC against inactivation, but D-histidine did not.	Histidine	0-11	histidine decarboxylase	Homo sapiens	36-39
32887365-7	2020	Furthermore, we systematically mutated histidine residues in the extracellular domain of ASIC1a or ASIC3 and found that histidine residues 72 and 73 in both ASIC1a and ASIC3, and histidine residue 83 in the ASIC3 were responsible for bidirectional effects on heteromeric ASIC1a/3 channels by zinc.	Histidine	120-129	acid-sensing (proton-gated) ion channel 1	Mus musculus	157-163
32887365-7	2020	Furthermore, we systematically mutated histidine residues in the extracellular domain of ASIC1a or ASIC3 and found that histidine residues 72 and 73 in both ASIC1a and ASIC3, and histidine residue 83 in the ASIC3 were responsible for bidirectional effects on heteromeric ASIC1a/3 channels by zinc.	Histidine	120-129	acid-sensing (proton-gated) ion channel 3	Mus musculus	168-173
32887365-7	2020	Furthermore, we systematically mutated histidine residues in the extracellular domain of ASIC1a or ASIC3 and found that histidine residues 72 and 73 in both ASIC1a and ASIC3, and histidine residue 83 in the ASIC3 were responsible for bidirectional effects on heteromeric ASIC1a/3 channels by zinc.	Histidine	120-129	acid-sensing (proton-gated) ion channel 3	Mus musculus	168-173
32887365-8	2020	These findings suggest that histidine residues in the extracellular domain of heteromeric ASIC1a/3 channels are critical for zinc-mediated effects.	Histidine	28-37	acid-sensing (proton-gated) ion channel 1	Mus musculus	90-98
6371807-6	1984	Two of the five glucosamine oligosaccharides are present in a histidine-rich sequence of the middle region of the protein, in which the histidines flank beta-turns presumably at the surface of hemopexin.	Histidine	62-71	hemopexin	Homo sapiens	193-202
6371807-6	1984	Two of the five glucosamine oligosaccharides are present in a histidine-rich sequence of the middle region of the protein, in which the histidines flank beta-turns presumably at the surface of hemopexin.	Histidine	136-146	hemopexin	Homo sapiens	193-202
6414519-0	1983	Proton nuclear magnetic resonance studies of histidines in horse carbonic anhydrase I.	Histidine	45-55	carbonic anhydrase 1	Equus caballus	65-85
32871846-5	2020	RESULTS: Ivermectin docked in the region of leucine 91 of the spike and histidine 378 of the ACE2 receptor.	Histidine	72-81	angiotensin converting enzyme 2	Homo sapiens	93-97
6300123-1	1983	The HIS1 gene of Saccharomyces cerevisiae encodes ATP phosphoribosyltransferase, the first enzyme in the pathway of histidine biosynthesis.	Histidine	116-125	ATP phosphoribosyltransferase	Saccharomyces cerevisiae S288C	4-8
32579975-5	2020	Only when PD-1 interacts with PD-L1 did the FSY react with a proximal histidine of PD-L1 selectively, enabling irreversible binding of PD-1 to only PD-L1 in vitro and in vivo.	Histidine	70-79	programmed cell death 1	Homo sapiens	10-14
32579975-5	2020	Only when PD-1 interacts with PD-L1 did the FSY react with a proximal histidine of PD-L1 selectively, enabling irreversible binding of PD-1 to only PD-L1 in vitro and in vivo.	Histidine	70-79	programmed cell death 1	Homo sapiens	135-139
32350111-7	2020	We demonstrate that unique BMP15 finger residues at this site (Arg-301, Gly-304, His-307, and Met-369) enable potent activation of the SMAD2/3 pathway.	Histidine	81-84	SMAD family member 2	Homo sapiens	135-142
6300123-1	1983	The HIS1 gene of Saccharomyces cerevisiae encodes ATP phosphoribosyltransferase, the first enzyme in the pathway of histidine biosynthesis.	Histidine	116-125	ATP phosphoribosyltransferase	Saccharomyces cerevisiae S288C	50-79
32350116-5	2020	In this study, using truncated FUT8 constructs, immunofluorescence staining, FACS analysis, cell-surface biotinylation, proteomics, and LC-electrospray ionization MS analyses, we reveal that the SH3 domain is essential for FUT8 activity both in cells and in vitro and identified His-535 in the SH3 domain as the critical residue for enzymatic activity of FUT8.	Histidine	279-282	fucosyltransferase 8	Homo sapiens	31-35
6860759-7	1983	For glycoprotein and mucin, binding is taken to occur via the sialic acid carboxylate groups and for amylase via the imidazole groups of the histidine residues.	Histidine	141-150	LOC100508689	Homo sapiens	21-26
32448098-8	2021	The major hot spot amino acids involved in the binding identified by interaction analysis after simulations includes Glu 35, Tyr 83, Asp 38, Lys 31, Glu 37, His 34 amino acid residues of ACE2 receptor and Gln 493, Gln 498, Asn 487, Tyr 505 and Lys 417 residues in nCoV S-protein RBD.	Histidine	157-160	angiotensin converting enzyme 2	Homo sapiens	187-191
16229164-5	1983	The "stability in vitro" toward enzymes of serum and brain homogenate of a new type of drug based on the combination of peptidic fragment of TRH-(Thyrotropin-Releasing Hormone:pGlu-His-Pro-NH2) with a non peptide moiety (dopamine) is considered and discussed.	Histidine	181-184	thyrotropin releasing hormone	Homo sapiens	141-175
32474857-1	2020	In order to demonstrate the relationship between methylation of fragile histidine triad (FHIT) and T-cadherin/H-cadherin (CDH13) genes and liver cancer, the methylation status of FHIT and CDH13 was detected in healthy individuals and in Mongolian and Han patients with liver cancer.	Histidine	72-81	fragile histidine triad diadenosine triphosphatase	Homo sapiens	89-93
32474857-1	2020	In order to demonstrate the relationship between methylation of fragile histidine triad (FHIT) and T-cadherin/H-cadherin (CDH13) genes and liver cancer, the methylation status of FHIT and CDH13 was detected in healthy individuals and in Mongolian and Han patients with liver cancer.	Histidine	72-81	fragile histidine triad diadenosine triphosphatase	Homo sapiens	179-183
6281785-1	1982	alpha-Melanocyte-stimulating hormone (alpha-melanotropin; alpha-MSH) is a linear tridecapeptide (Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2) that reversibly darkens amphibian skins by stimulating melanomsome (pigment granule) dispersion within melanophores.	Histidine	120-123	pro-opiomelanocortin-alpha	Mus musculus	0-36
32237123-2	2020	With the aim of refining the target population for anti-HER2 therapies in NSCLC, we investigated the relationships between HER2 and the tumour suppressor fragile histidine triad (FHIT) in lung tumour cells.	Histidine	162-171	fragile histidine triad diadenosine triphosphatase	Homo sapiens	179-183
7053386-1	1982	Inactivation of porcine heart mitochondrial malate dehydrogenase (L-malate: NAD+ oxidoreductase, EC 1.1.1.37) by selective modification of an active center histidine residue with the reagent iodoacetamide has been further investigated to examine the existence of and the enzymatic activity of a hybrid (half)-modified dimer.	Histidine	156-165	hydroxysteroid 17-beta dehydrogenase 6	Homo sapiens	81-95
31730800-1	2020	Bile acid (BA) imbalance may be directly associated with gastric cancer and indirectly influence stomach carcinogenesis via overexpression of histidine decarboxylase (HDC), which converts histidine (His) into histamine (HIST).	Histidine	142-151	histidine decarboxylase	Homo sapiens	167-170
31730800-1	2020	Bile acid (BA) imbalance may be directly associated with gastric cancer and indirectly influence stomach carcinogenesis via overexpression of histidine decarboxylase (HDC), which converts histidine (His) into histamine (HIST).	Histidine	199-202	histidine decarboxylase	Homo sapiens	142-165
31730800-1	2020	Bile acid (BA) imbalance may be directly associated with gastric cancer and indirectly influence stomach carcinogenesis via overexpression of histidine decarboxylase (HDC), which converts histidine (His) into histamine (HIST).	Histidine	199-202	histidine decarboxylase	Homo sapiens	167-170
7026531-6	1981	Low-affinity transport was inhibited by histidine, so put4 mutants were unable to grow on a medium containing high concentrations of proline to which histidine has been added.	Histidine	40-49	proline permease PUT4	Saccharomyces cerevisiae S288C	54-58
33582986-0	2020	Quantifying the Interaction of Phosphite with ABC Transporters: MicroScale Thermophoresis and a Novel His-Tag Labeling Approach.	Histidine	102-105	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	46-49
7026531-6	1981	Low-affinity transport was inhibited by histidine, so put4 mutants were unable to grow on a medium containing high concentrations of proline to which histidine has been added.	Histidine	150-159	proline permease PUT4	Saccharomyces cerevisiae S288C	54-58
7282485-6	1981	(3) HDC activity was not detected in muscle, but doubled from the lowest to the highest histidine intake in brain and increased almost 6-fold between the lowest and the highest histidine levels in stomach.	Histidine	88-97	histidine decarboxylase	Rattus norvegicus	4-7
7282485-6	1981	(3) HDC activity was not detected in muscle, but doubled from the lowest to the highest histidine intake in brain and increased almost 6-fold between the lowest and the highest histidine levels in stomach.	Histidine	177-186	histidine decarboxylase	Rattus norvegicus	4-7
7282485-7	1981	(4) Kidney HDC decreased from the lowest to the two higher levels of dietary histidine.	Histidine	77-86	histidine decarboxylase	Rattus norvegicus	11-14
31401272-4	2019	We have observed that while the migration of acidic bovine serum albumin (BSA) was independent of the buffer concentration, the behavior of basic lysozyme was greatly improved at higher buffer concentration, e.g., 100 mM histidine-100 mM MES.	Histidine	221-230	lysozyme C, tracheal isozyme	Bos taurus	146-154
7295770-2	1981	The single histidine of the protein is located at position 29 as in horse colipase A.	Histidine	11-20	colipase	Equus caballus	74-84
31502464-5	2019	Modified forms of SUMO1 or SUMO2, with a histidine tag and a Thr to Lys mutation preceding the carboxyl-terminal di-gly motif, were expressed in mpkCCD14 cells, allowing SUMO-conjugated proteins to be purified and identified.	Histidine	41-50	small ubiquitin like modifier 1	Homo sapiens	18-23
6788956-2	1981	Practical syntheses for three of these TRH analogues which show the greatest selectivity, less than Aad-His-Tzl-NH2 (5), less than Glu-His-Pip-OMe (2), and less than Aad-His-Pro-NH2 (6), are described.	Histidine	104-107	thyrotropin releasing hormone	Homo sapiens	39-42
31351182-6	2019	Furthermore, one residue located at 10 A distance from the catalytic site is different between the sub-families but highly conserved within each sub-family (Asp in AOC1, His in AOC2, Thr in AOC3 and Asn in AOC4) and likely contributes to substrate selectivity.	Histidine	170-173	amine oxidase copper containing 3	Homo sapiens	190-194
31351182-6	2019	Furthermore, one residue located at 10 A distance from the catalytic site is different between the sub-families but highly conserved within each sub-family (Asp in AOC1, His in AOC2, Thr in AOC3 and Asn in AOC4) and likely contributes to substrate selectivity.	Histidine	170-173	amine oxidase copper containing 4, pseudogene	Homo sapiens	206-210
7236849-6	1981	The observation that filling the hydrophobic vacancy on the proximal side of the heme near the proximal histidine in Met-cyano myoglobin wih cyclopropane increases the proton lability argues against the role for this hole in facilitating the flexibility of the F helix in the native protein.	Histidine	104-113	myoglobin	Physeter catodon	127-136
31274304-3	2019	The parameters allowed exchange of the water molecules coordinating the zinc ion and proved to be robust enough to enable reliable modeling not only of human DPP III and its orthologues but also of the other zinc-dependent peptidases with the zinc ion coordination similar to that in dipeptidyl peptidases III, i.e., peptidases with the zinc ion coordinated with two histidines and one glutamate.	Histidine	367-377	dipeptidyl peptidase 3	Homo sapiens	158-165
6164370-0	1981	Diethylpyrocarbonate inhibition of estrogen binding to rat alpha-fetoprotein: evidence that one or more histidine residues regulate estrogen binding.	Histidine	104-113	alpha-fetoprotein	Rattus norvegicus	59-76
31296657-5	2019	To overcome this limitation, here we investigated a CysRS from the selenium accumulator plant Astragalus bisulcatus that is reported to reject Sec in vitro Sequence analysis revealed a rare His   Asn variation adjacent to the CysRS catalytic pocket.	Histidine	190-193	cysteinyl-tRNA synthetase 1	Homo sapiens	52-57
31510033-3	2019	Moreover, the expression of tyrosine (tdc) and histidine (hdc) decarboxylases genes was evaluated by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR).	Histidine	47-56	histidine decarboxylase	Sus scrofa	58-61
6256747-6	1980	When the temperature or the hemoglobin concentration was increased (i) several additional histidine resonances in sickle hemoglobin solutions had larger T1-1 values than the corresponding ones in normal hemoglobin and (ii) the differences between the T1-1 values (sickle versus normal hemoglobin) of these histidine resonances as well as that of the beta 2 histidine resonance gradually increased.	Histidine	90-99	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	350-356
7410379-3	1980	Proton nuclear magnetic resonance measurements indicate that in the peptide beta (1-55) from hemoglobin S this residue is the histidine at beta 2.	Histidine	126-135	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	139-145
31388018-2	2019	We report that in a pre-reactive complex SETD3 binds the N3-protonated form (N3-H) of actin His73, and in a post-reactive product complex, SETD3 generates the methylated histidine in an N1-protonated (N1-H) and N3-methylated form.	Histidine	170-179	SET domain containing 3, actin histidine methyltransferase	Homo sapiens	41-46
31388018-2	2019	We report that in a pre-reactive complex SETD3 binds the N3-protonated form (N3-H) of actin His73, and in a post-reactive product complex, SETD3 generates the methylated histidine in an N1-protonated (N1-H) and N3-methylated form.	Histidine	170-179	SET domain containing 3, actin histidine methyltransferase	Homo sapiens	139-144
31388018-5	2019	The structure of SETD3 with Lys73-containing peptide reveals a bent conformation of Lys73, with its side chain aliphatic carbons tracing along the edge of imidazole ring and the terminal epsilon-amino group occupying a position nearly identical to the N3 atom of unmethylated histidine.	Histidine	276-285	SET domain containing 3, actin histidine methyltransferase	Homo sapiens	17-22
6987534-4	1980	A dodecapeptide analogue [des-Ala, Gly] His-D-Trp-SRIF (Wy-41, 747) has been identified that combines selective inhibition of GH and glucagon release with prolonged activity.	Histidine	40-43	gonadotropin releasing hormone receptor	Rattus norvegicus	126-128
31107136-5	2019	Mutating VH CDR3 only, we identified a dominant "solution" involving substitution of a central tyrosine to histidine.	Histidine	107-116	CDR3	Homo sapiens	12-16
31209918-9	2019	Recombinant UPase (rUPase) tagged with His at the C-terminal amino acid was purified with Ni affinity chromatography.	Histidine	39-42	uridine phosphorylase	Pasteurella multocida	12-17
31150776-1	2019	Human mitochondrial matrix protein Miner2 hosts two [2Fe-2S] clusters via two CDGSH (Cys-Asp-Gly-Ser-His) motifs.	Histidine	101-104	CDGSH iron sulfur domain 3	Homo sapiens	35-41
17249001-7	1980	It is proposed that the effect of THR4 is caused by aggregation of the wild-type threonine synthetase with defective his1-1S monomers, causing a favorable conformational change in the histidine protein that restores limited enzymatic activity.	Histidine	184-193	ATP phosphoribosyltransferase	Saccharomyces cerevisiae S288C	117-121
488354-0	1979	The C-terminal fragment of human glutathione reductase contains the postulated catalytic histidine.	Histidine	89-98	glutathione-disulfide reductase	Homo sapiens	33-54
30744784-6	2019	Pyrroloquinoline quinone (PQQ)-dependent glucose dehydrogenase (GDH) was immobilized on the CNT surface through a genetically introduced His-tag.	Histidine	137-140	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	41-62
30744784-6	2019	Pyrroloquinoline quinone (PQQ)-dependent glucose dehydrogenase (GDH) was immobilized on the CNT surface through a genetically introduced His-tag.	Histidine	137-140	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	64-67
30836141-3	2019	In this study, the asparaginase II-encoding gene ASP3 from Saccharomyces cerevisiae was cloned into the expression vector pET28a in-fusion with a 6x histidine tag and was expressed in Escherichia coli BL21 (DE3) cells.	Histidine	149-158	asparaginase ASP3-1	Saccharomyces cerevisiae S288C	49-53
30851618-8	2019	CER1 and CER3 proteins are structurally similar, but CER1 proteins have more conserved histidine-containing motifs common to fatty acid hydroxylases and stearoyl-CoA desaturases.	Histidine	87-96	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	0-4
30851618-8	2019	CER1 and CER3 proteins are structurally similar, but CER1 proteins have more conserved histidine-containing motifs common to fatty acid hydroxylases and stearoyl-CoA desaturases.	Histidine	87-96	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	9-13
30851618-8	2019	CER1 and CER3 proteins are structurally similar, but CER1 proteins have more conserved histidine-containing motifs common to fatty acid hydroxylases and stearoyl-CoA desaturases.	Histidine	87-96	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	53-57
30826412-8	2019	Furthermore, based on the in vivo neutralization assay, recombinant His-beta-actin accelerated the infection of WSSV, conversely, recombinant His-Rab7 delayed WSSV infection in shrimp.	Histidine	142-145	RAB7B, member RAS oncogene family	Homo sapiens	146-150
30242938-4	2019	Notably, the fragile locus, FRA3B, lies within the fragile histidine triad (FHIT) gene, and consequently deletions within FHIT are common in cancer.	Histidine	59-68	fragile histidine triad diadenosine triphosphatase	Homo sapiens	28-33
30242938-4	2019	Notably, the fragile locus, FRA3B, lies within the fragile histidine triad (FHIT) gene, and consequently deletions within FHIT are common in cancer.	Histidine	59-68	fragile histidine triad diadenosine triphosphatase	Homo sapiens	76-80
30242938-4	2019	Notably, the fragile locus, FRA3B, lies within the fragile histidine triad (FHIT) gene, and consequently deletions within FHIT are common in cancer.	Histidine	59-68	fragile histidine triad diadenosine triphosphatase	Homo sapiens	122-126
31010094-9	2019	Moreover, site directed mutations identified that the conserved catalytic triad of CesH might consist of Serine 86, Glutamate 199, and Histidine 227.	Histidine	135-144	cesH	Bacillus cereus	83-87
30586560-0	2019	Development of a novel l-histidine assay method using histamine dehydrogenase and a stable mutant of histidine decarboxylase.	Histidine	23-34	histidine decarboxylase	Homo sapiens	101-124
30586560-3	2019	Here, we describe a novel l-histidine quantitation assay using a combination of histidine decarboxylase (HDC) and histamine dehydrogenase (HDH) enzymes.	Histidine	26-37	histidine decarboxylase	Homo sapiens	80-103
30586560-3	2019	Here, we describe a novel l-histidine quantitation assay using a combination of histidine decarboxylase (HDC) and histamine dehydrogenase (HDH) enzymes.	Histidine	26-37	histidine decarboxylase	Homo sapiens	105-108
31105210-4	2019	Inspired by byssal threads, we bioengineered His-metal coordination sites into a heterodimeric coiled coil (CC).	Histidine	45-48	coilin	Homo sapiens	95-99
30785395-0	2019	Structural insights into SETD3-mediated histidine methylation on beta-actin.	Histidine	40-49	SET domain containing 3, actin histidine methyltransferase	Homo sapiens	25-30
30446621-5	2019	We found that this binding is mediated by the highly conserved His-88 residue in CAIV, which is also the central residue of the enzyme"s intramolecular proton shuttle, and a charged amino acid residue in the Ig1 domain of the chaperone.	Histidine	63-66	carbonic anhydrase 4	Homo sapiens	81-85
30446621-9	2019	Further analysis of the CAIV-binding site revealed that the His-88 in CAIV can either act as H donor or H acceptor for the hydrogen bond, depending on the charge of the binding residue in the chaperone.	Histidine	60-63	carbonic anhydrase 4	Homo sapiens	24-28
30446621-9	2019	Further analysis of the CAIV-binding site revealed that the His-88 in CAIV can either act as H donor or H acceptor for the hydrogen bond, depending on the charge of the binding residue in the chaperone.	Histidine	60-63	carbonic anhydrase 4	Homo sapiens	70-74
30446621-10	2019	Our results suggest that the CAIV-mediated increase in MCT transport activity requires direct binding between CAIV-His-88 and a charged amino acid in the extracellular domain of the transporter"s chaperone.	Histidine	115-118	carbonic anhydrase 4	Homo sapiens	29-33
30446621-10	2019	Our results suggest that the CAIV-mediated increase in MCT transport activity requires direct binding between CAIV-His-88 and a charged amino acid in the extracellular domain of the transporter"s chaperone.	Histidine	115-118	carbonic anhydrase 4	Homo sapiens	110-114
31457039-5	2019	Results: The recombinant UL31 protein consisting of N-terminal 27 aa of UL31 was fused to EYFP and His-tag.	Histidine	99-102	nuclear egress lamina protein	Human alphaherpesvirus 1	25-29
30397769-3	2019	Histidine was found to be essential for the growth of Kmmig1, but not that of Kmrag5, suggesting that MIG1 is required for histidine biosynthesis in K. marxianus.	Histidine	0-9	transcription factor MIG1	Saccharomyces cerevisiae S288C	102-106
30397769-3	2019	Histidine was found to be essential for the growth of Kmmig1, but not that of Kmrag5, suggesting that MIG1 is required for histidine biosynthesis in K. marxianus.	Histidine	123-132	transcription factor MIG1	Saccharomyces cerevisiae S288C	102-106
30836148-5	2019	METHODS: The hypothesis to be tested is that ESCC GFIP induced by glucose is facilitated by PEP-mediated histidine phosphorylation (poHis) of FAK, leading to the possibility that ESCC progression can be targeted by blocking poHis signaling.	Histidine	105-114	protein tyrosine kinase 2	Homo sapiens	142-145
30836148-13	2019	ESCC progression is controlled by actionable growth factor-independent, glucose-induced pathways that regulate proliferation through novel histidine phosphorylation of FAK.	Histidine	139-148	protein tyrosine kinase 2	Homo sapiens	168-171
30457328-8	2018	In order to study the reactivity of the compounds with biomolecules, the interaction of complexes 3-PF6 and 5-PF6 with the protein cytochrome c and the amino acids cysteine and histidine was analyzed by electrospray ionization mass spectrometry (ESI MS), showing adduct formation only with Cys after at least 1 h incubation.	Histidine	177-186	sperm associated antigen 17	Homo sapiens	100-103
30457328-8	2018	In order to study the reactivity of the compounds with biomolecules, the interaction of complexes 3-PF6 and 5-PF6 with the protein cytochrome c and the amino acids cysteine and histidine was analyzed by electrospray ionization mass spectrometry (ESI MS), showing adduct formation only with Cys after at least 1 h incubation.	Histidine	177-186	sperm associated antigen 17	Homo sapiens	110-113
30301773-5	2018	We found M20 to be an His-Asn-His/Asn (H-N-H/N) nuclease that degrades linear and circular DNA in the presence of Mg2+ or Mn2+ Arabidopsis (Arabidopsis thaliana) AtM20, which shared high sequence similarity with maize M20, localized to the mitochondria, had a similar H-N-H/N structure, and degraded both linear and circular DNA.	Histidine	22-25	MADS-box transcription factor 47	Zea mays	9-12
30301773-5	2018	We found M20 to be an His-Asn-His/Asn (H-N-H/N) nuclease that degrades linear and circular DNA in the presence of Mg2+ or Mn2+ Arabidopsis (Arabidopsis thaliana) AtM20, which shared high sequence similarity with maize M20, localized to the mitochondria, had a similar H-N-H/N structure, and degraded both linear and circular DNA.	Histidine	22-25	MADS-box transcription factor 47	Zea mays	164-167
30301773-5	2018	We found M20 to be an His-Asn-His/Asn (H-N-H/N) nuclease that degrades linear and circular DNA in the presence of Mg2+ or Mn2+ Arabidopsis (Arabidopsis thaliana) AtM20, which shared high sequence similarity with maize M20, localized to the mitochondria, had a similar H-N-H/N structure, and degraded both linear and circular DNA.	Histidine	30-33	MADS-box transcription factor 47	Zea mays	9-12
30301773-5	2018	We found M20 to be an His-Asn-His/Asn (H-N-H/N) nuclease that degrades linear and circular DNA in the presence of Mg2+ or Mn2+ Arabidopsis (Arabidopsis thaliana) AtM20, which shared high sequence similarity with maize M20, localized to the mitochondria, had a similar H-N-H/N structure, and degraded both linear and circular DNA.	Histidine	30-33	MADS-box transcription factor 47	Zea mays	164-167
30380295-6	2018	Introduction of a solubility partner, i.e., maltose binding protein (MBP), at the N-terminus of the ATR kinase domain generated a soluble form of the protein, i.e., MBP-tagged hATR kinase domain (MBP-ATR-6X His), which was found to be catalytically active, as assessed by substrate p53 Ser-15 phosphorylation (EPPLSQEAFADLWKK).	Histidine	207-210	myelin basic protein	Homo sapiens	44-67
30380295-6	2018	Introduction of a solubility partner, i.e., maltose binding protein (MBP), at the N-terminus of the ATR kinase domain generated a soluble form of the protein, i.e., MBP-tagged hATR kinase domain (MBP-ATR-6X His), which was found to be catalytically active, as assessed by substrate p53 Ser-15 phosphorylation (EPPLSQEAFADLWKK).	Histidine	207-210	myelin basic protein	Homo sapiens	69-72
30380295-6	2018	Introduction of a solubility partner, i.e., maltose binding protein (MBP), at the N-terminus of the ATR kinase domain generated a soluble form of the protein, i.e., MBP-tagged hATR kinase domain (MBP-ATR-6X His), which was found to be catalytically active, as assessed by substrate p53 Ser-15 phosphorylation (EPPLSQEAFADLWKK).	Histidine	207-210	myelin basic protein	Homo sapiens	165-168
30380295-6	2018	Introduction of a solubility partner, i.e., maltose binding protein (MBP), at the N-terminus of the ATR kinase domain generated a soluble form of the protein, i.e., MBP-tagged hATR kinase domain (MBP-ATR-6X His), which was found to be catalytically active, as assessed by substrate p53 Ser-15 phosphorylation (EPPLSQEAFADLWKK).	Histidine	207-210	myelin basic protein	Homo sapiens	165-168
30064080-7	2018	Molecular docking and Site Finder module defined the thieno[2,3-d]pyrimidines interactions with the most important catalytic residues of DNase I, including Glu 39, His 134, Asp 168 and His 252.	Histidine	164-167	deoxyribonuclease 1	Bos taurus	137-144
30064080-7	2018	Molecular docking and Site Finder module defined the thieno[2,3-d]pyrimidines interactions with the most important catalytic residues of DNase I, including Glu 39, His 134, Asp 168 and His 252.	Histidine	185-188	deoxyribonuclease 1	Bos taurus	137-144
30029049-0	2018	The zinc transporter SLC39A7 (ZIP7) harbours a highly-conserved histidine-rich N-terminal region that potentially contributes to zinc homeostasis in the endoplasmic reticulum.	Histidine	64-73	solute carrier family 39 member 7	Homo sapiens	4-28
30029049-0	2018	The zinc transporter SLC39A7 (ZIP7) harbours a highly-conserved histidine-rich N-terminal region that potentially contributes to zinc homeostasis in the endoplasmic reticulum.	Histidine	64-73	solute carrier family 39 member 7	Homo sapiens	30-34
30029049-8	2018	Analysis of the amino acid sequence of ZIP7 revealed several potential histidine binding sites for zinc in the N-terminal region that were significantly different in comparison to the other members of this family.	Histidine	71-80	solute carrier family 39 member 7	Homo sapiens	39-43
30029049-9	2018	Moreover, this histidine-rich region in the N-terminal of ZIP7 was highly conserved across the animal and plant kingdom.	Histidine	15-24	solute carrier family 39 member 7	Homo sapiens	58-62
30029049-10	2018	Accordingly, the highly conserved histidine-rich region in the N-termini of ZIP7 across the animal and plant kingdom suggests that this domain has critical function(s).	Histidine	34-43	solute carrier family 39 member 7	Homo sapiens	76-80
30029049-11	2018	We hypothesise that ER-localized ZIP7 can potentially sequester zinc to these histidine-rich regions and therefore provides a mechanism that is protective of this cellular structure.	Histidine	78-87	solute carrier family 39 member 7	Homo sapiens	33-37
29888867-3	2018	We recently identified a disulfide-bridged nonapeptide, named PTPRJ-19 (H-[Cys-His-His-Asn-Leu-Thr-His-Ala-Cys]-OH), which activates PTPRJ, thereby causing cell growth inhibition and apoptosis of both cancer and endothelial cells.	Histidine	79-82	protein tyrosine phosphatase receptor type J	Homo sapiens	62-67
29888867-3	2018	We recently identified a disulfide-bridged nonapeptide, named PTPRJ-19 (H-[Cys-His-His-Asn-Leu-Thr-His-Ala-Cys]-OH), which activates PTPRJ, thereby causing cell growth inhibition and apoptosis of both cancer and endothelial cells.	Histidine	79-82	protein tyrosine phosphatase receptor type J	Homo sapiens	133-138
29888867-3	2018	We recently identified a disulfide-bridged nonapeptide, named PTPRJ-19 (H-[Cys-His-His-Asn-Leu-Thr-His-Ala-Cys]-OH), which activates PTPRJ, thereby causing cell growth inhibition and apoptosis of both cancer and endothelial cells.	Histidine	83-86	protein tyrosine phosphatase receptor type J	Homo sapiens	62-67
29888867-3	2018	We recently identified a disulfide-bridged nonapeptide, named PTPRJ-19 (H-[Cys-His-His-Asn-Leu-Thr-His-Ala-Cys]-OH), which activates PTPRJ, thereby causing cell growth inhibition and apoptosis of both cancer and endothelial cells.	Histidine	83-86	protein tyrosine phosphatase receptor type J	Homo sapiens	133-138
29937240-13	2018	The net iAUC of five of these amino acids (i.e. arginine, asparagine, histidine, serine and threonine) was more than 10% higher in subjects with high responses on GLP-1 and/or PYY (P &lt; 0.05).	Histidine	70-79	glucagon like peptide 1 receptor	Homo sapiens	163-168
29870126-1	2018	Reaction of the Au-C N chelate [Au(bnpy)Cl2 ] with the full-length zinc finger (ZnF; ZnCys3 His) of HIV nucleocapsid protein NCp7 results in C-S aryl transfer from the AuIII organometallic species to a cysteine of the ZnF.	Histidine	92-95	zinc finger protein 763	Homo sapiens	67-78
29870126-1	2018	Reaction of the Au-C N chelate [Au(bnpy)Cl2 ] with the full-length zinc finger (ZnF; ZnCys3 His) of HIV nucleocapsid protein NCp7 results in C-S aryl transfer from the AuIII organometallic species to a cysteine of the ZnF.	Histidine	92-95	zinc finger protein 763	Homo sapiens	80-83
29870126-1	2018	Reaction of the Au-C N chelate [Au(bnpy)Cl2 ] with the full-length zinc finger (ZnF; ZnCys3 His) of HIV nucleocapsid protein NCp7 results in C-S aryl transfer from the AuIII organometallic species to a cysteine of the ZnF.	Histidine	92-95	zinc finger protein 763	Homo sapiens	218-221
29664293-3	2018	This study shows that PMS without explicit activation undergoes direct reaction with a variety of compounds, including antibiotics, pharmaceuticals, phenolics, and commonly used singlet-oxygen (1O2) traps and quenchers, specifically furfuryl alcohol (FFA), azide, and histidine.	Histidine	268-277	proline rich protein BstNI subfamily 1	Homo sapiens	22-25
29675012-8	2018	Interestingly, we found a sharply down-regulated enzyme [A0A068E9J3 imidazoleglycerol-phosphate dehydratase (IGPD)] involved in histidine metabolism pathway in cefquinome-treated cells.	Histidine	128-137	imidazoleglycerol-phosphate dehydratase HisB	Staphylococcus xylosus	68-107
29675012-8	2018	Interestingly, we found a sharply down-regulated enzyme [A0A068E9J3 imidazoleglycerol-phosphate dehydratase (IGPD)] involved in histidine metabolism pathway in cefquinome-treated cells.	Histidine	128-137	imidazoleglycerol-phosphate dehydratase HisB	Staphylococcus xylosus	109-113
29675012-9	2018	We demonstrated the important role of IGPD in sub-MICs cefquinome inhibiting biofilm formation of S. xylosus by gene (hisB) knockout, IGPD enzyme activity and histidine content assays.	Histidine	159-168	imidazoleglycerol-phosphate dehydratase HisB	Staphylococcus xylosus	38-42
29675012-10	2018	Thus, our data sheds light on important role of histidine metabolism in S. xylosus biofilm formation; especially, IGPD involved in histidine metabolism might play a crucial role in sub-MICs cefquinome inhibition of biofilm formation of S. xylosus, and we propose IGPD as an attractive protein target of cefquinome.	Histidine	48-57	imidazoleglycerol-phosphate dehydratase HisB	Staphylococcus xylosus	114-118
29675012-10	2018	Thus, our data sheds light on important role of histidine metabolism in S. xylosus biofilm formation; especially, IGPD involved in histidine metabolism might play a crucial role in sub-MICs cefquinome inhibition of biofilm formation of S. xylosus, and we propose IGPD as an attractive protein target of cefquinome.	Histidine	131-140	imidazoleglycerol-phosphate dehydratase HisB	Staphylococcus xylosus	114-118
29675012-10	2018	Thus, our data sheds light on important role of histidine metabolism in S. xylosus biofilm formation; especially, IGPD involved in histidine metabolism might play a crucial role in sub-MICs cefquinome inhibition of biofilm formation of S. xylosus, and we propose IGPD as an attractive protein target of cefquinome.	Histidine	131-140	imidazoleglycerol-phosphate dehydratase HisB	Staphylococcus xylosus	263-267
28460164-5	2018	As expected, our hybrid molecule 10 [SNIPER(CH6)] efficiently degraded His-tagged CRABP-II and Smad2 in cells.	Histidine	71-74	SMAD family member 2	Homo sapiens	95-100
29747024-7	2018	We propose that the double pi-pi interactions of the F259 residue with the -2 and -3 nucleobases serve to position the nucleopeptide substrate in phase with the active site histidines of hTDP1.	Histidine	173-183	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	187-192
29954247-8	2018	Removal of the C-terminal His-tag from Pr55Gag and Gag p6 uniformly increased the Kd values of the RNA-protein complexes by ~ 2.5 fold but did not affect the binding specificities of these proteins.	Histidine	26-29	Pr55(Gag)	Human immunodeficiency virus 1	39-46
29282095-3	2017	Fhit belongs to the histidine triad family of enzymes that catalyze the degradation of nucleoside 5",5"-triphosphates, including the m7GpppN "caps" that are generated when mRNAs undergo 3"-5" decay.	Histidine	20-29	fragile histidine triad diadenosine triphosphatase	Homo sapiens	0-4
29312931-2	2017	The results showed that three small proteins, including histidine biosynthesis protein (HisIE), iron donor protein (CyaY) and hypothetical protein_65aa, have a higher ability to adsorb gold ions because of the negatively charged domains or metal binding sites.	Histidine	56-65	frataxin	Homo sapiens	116-120
29220360-8	2017	We conclude that OR and site 5 histidine substitutions have divergent phenotypic impacts and that cis interactions between the OR region and the site 5 region modulate pathogenic outcomes by affecting the PrP globular domain.	Histidine	31-40	prion protein	Mus musculus	205-208
29203835-4	2017	We applied the obtained knowledge to successfully upscale purification of histidine tagged human AQP10 produced in large bioreactors.	Histidine	74-83	aquaporin 10	Homo sapiens	97-102
29058417-6	2017	The His-tagged fluorescent protein chimera consisted of a red fluorescent protein mCherry that acted as the fluorophore, the low-molecular-weight protamine peptide as the CPP, and the MMP-2 cleavage sequence fused with the hexahistidine tag, whereas the nickel ferrite nanoparticles functioned as the His-tagged protein binder and also the fluorescent quencher.	Histidine	4-7	matrix metallopeptidase 2	Homo sapiens	184-189
28988621-4	2017	Although the unfractionated mixture demonstrated weaker interaction/activation of the receptor, differently oxidized isolated subspecies can lead both to stronger as well as weaker binding and activation of the histidine variant of FcgammaRIIa.	Histidine	211-220	Fc gamma receptor IIa	Homo sapiens	232-243
28937773-8	2017	The overall results suggest that it is useful to consider three aspects of zinc finger structure in considering the profile of chemical reactivity: (i) the zinc-bound cysteines as primary nucleophiles; (ii) the zinc-bound histidine as a "spectator" ligand; and (iii) ancillary groups not bound to Zn but essential for ZnF function such as the essential tryptophan in NCp7 F2 and NC.	Histidine	222-231	zinc finger protein 763	Homo sapiens	318-321
28647331-0	2017	Combination of histidine, lysine, methionine, and leucine promotes beta-casein synthesis via the mechanistic target of rapamycin signaling pathway in bovine mammary epithelial cells.	Histidine	15-24	mechanistic target of rapamycin kinase	Bos taurus	97-128
28647331-15	2017	In conclusion, the extracellular concentrations of His, Lys, Met, and Leu at a ratio of 5:6:1:7 maximized beta-casein expression in the immortalized bovine mammary epithelial cell line may occur via activation of the mechanistic target of rapamycin complex 1 signaling pathway.	Histidine	51-54	mechanistic target of rapamycin kinase	Bos taurus	217-248
28774948-7	2017	We also found that DrHv1 is comparatively resistant to extracellular Zn2+, which is a potent inhibitor of mammalian Hv1, and this phenomenon appears to reflect variation in the Zn2+-coordinating residue (histidine) within the extracellular linker region in mammalian Hv1.	Histidine	204-213	hydrogen voltage gated channel 1	Homo sapiens	21-24
28774948-7	2017	We also found that DrHv1 is comparatively resistant to extracellular Zn2+, which is a potent inhibitor of mammalian Hv1, and this phenomenon appears to reflect variation in the Zn2+-coordinating residue (histidine) within the extracellular linker region in mammalian Hv1.	Histidine	204-213	hydrogen voltage gated channel 1	Homo sapiens	116-119
28695845-3	2017	ACHT1 (atypical cysteine/histidine-rich Trx1) is a thylakoid-associated thioredoxin-type protein found in the Arabidopsis thaliana chloroplast.	Histidine	25-34	thioredoxin H-type 1	Arabidopsis thaliana	40-44
28400162-3	2017	Here we expressed the ALOX15 orthologs of eight different mammalian species as well as human ALOX12 and ALOX15B as recombinant his-tag fusion proteins and characterized their reaction specificity with the most abundantly occurring polyunsaturated fatty acids (PUFAs) including 5,8,11,14,17-eicosapentaenoic acid (EPA) and 4,7,10,13,16,19-docosahexaenoic acid (DHA).	Histidine	127-130	arachidonate 12-lipoxygenase, 12S type	Homo sapiens	93-99
31130948-4	2019	FcmuR may have dual signaling ability: one through a potential as yet unidentified adaptor protein non-covalently associating with the FcmuR ligand-binding chain via a His in transmembrane segment and the other through its own Tyr and Ser residues in the cytoplasmic tail.	Histidine	168-171	Fc fragment of IgM receptor	Mus musculus	0-5
31130948-4	2019	FcmuR may have dual signaling ability: one through a potential as yet unidentified adaptor protein non-covalently associating with the FcmuR ligand-binding chain via a His in transmembrane segment and the other through its own Tyr and Ser residues in the cytoplasmic tail.	Histidine	168-171	Fc fragment of IgM receptor	Mus musculus	135-140
30835471-0	2019	Role of Conserved Histidine and Serine in the HCXXXXXRS Motif of Human Dual-Specificity Phosphatase 5.	Histidine	18-27	dual specificity phosphatase 5	Homo sapiens	71-101
30944775-10	2019	Results: Immunized birds produced a strong serum IgY response against both the plant produced PlcC-NetB protein and against bacterially produced His-PlcC and His-NetB.	Histidine	158-161	netB	Clostridium perfringens	162-166
30390369-5	2019	We have previously demonstrated the unique conjugation between the dihydrolipoamide dehydrogenase (DLDH) protein and TiO2 surfaces, based on specific coordinative bonding via Cys-His-Glu-Asp motif residues.	Histidine	179-182	dihydrolipoamide dehydrogenase	Homo sapiens	67-97
30390369-5	2019	We have previously demonstrated the unique conjugation between the dihydrolipoamide dehydrogenase (DLDH) protein and TiO2 surfaces, based on specific coordinative bonding via Cys-His-Glu-Asp motif residues.	Histidine	179-182	dihydrolipoamide dehydrogenase	Homo sapiens	99-103
30785395-3	2019	Here, we present two structures of S-adenosyl-L-homocysteine-bound SETD3 in complex with either an unmodified beta-actin peptide or its His-methylated variant.	Histidine	136-139	SET domain containing 3, actin histidine methyltransferase	Homo sapiens	67-72
30785395-5	2019	In conclusion, this study is the first to show a catalytic mechanism of SETD3-mediated histidine methylation on beta-actin, which not only throws light on the protein histidine methylation phenomenon but also facilitates the design of small molecule inhibitors of SETD3.	Histidine	87-96	SET domain containing 3, actin histidine methyltransferase	Homo sapiens	72-77
30785395-5	2019	In conclusion, this study is the first to show a catalytic mechanism of SETD3-mediated histidine methylation on beta-actin, which not only throws light on the protein histidine methylation phenomenon but also facilitates the design of small molecule inhibitors of SETD3.	Histidine	87-96	SET domain containing 3, actin histidine methyltransferase	Homo sapiens	264-269
30785395-5	2019	In conclusion, this study is the first to show a catalytic mechanism of SETD3-mediated histidine methylation on beta-actin, which not only throws light on the protein histidine methylation phenomenon but also facilitates the design of small molecule inhibitors of SETD3.	Histidine	167-176	SET domain containing 3, actin histidine methyltransferase	Homo sapiens	72-77
30785395-5	2019	In conclusion, this study is the first to show a catalytic mechanism of SETD3-mediated histidine methylation on beta-actin, which not only throws light on the protein histidine methylation phenomenon but also facilitates the design of small molecule inhibitors of SETD3.	Histidine	167-176	SET domain containing 3, actin histidine methyltransferase	Homo sapiens	264-269
30535142-4	2019	Using CRISPR knockout, we show that CRHR1 is necessary for acid-induced POMC expression, and this induction is mediated by CRHR1 histidine residues and calmodulin-dependent protein kinase II in both pituitary corticotroph cells and in nonpituitary cell lines expressing ectopic ACTH.	Histidine	129-138	pro-opiomelanocortin-alpha	Mus musculus	72-76
30697165-6	2018	Allosteric modulators of calcium-sensing receptor (CaSR) and G-protein coupled receptor class C group 6 member A (GPRC6A) had inhibitory effects on cell death induced by L-arginine but not L-ornithine or L-histidine.	Histidine	204-215	calcium-sensing receptor	Mus musculus	51-55
30941950-1	2019	PURPOSE: The study aimed to investigate the expression level of fragile histidine triad (FHIT) in breast cancer and analyze its prognostic value.	Histidine	72-81	fragile histidine triad diadenosine triphosphatase	Homo sapiens	89-93
30655841-1	2019	Effects of interventional embolotherapy on the expression of fragile histidine triad (FHIT) and p16 in hepatocellular carcinoma (HCC) patients were investigated.	Histidine	69-78	fragile histidine triad diadenosine triphosphatase	Homo sapiens	86-90
30120407-11	2019	Brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), hepatocyte growth factor (HGF), and stromal cell-derived factor-1 (SDF-1) gene expressions in hAFS were elevated when exposed to HI-induced brain extract.	Histidine	198-200	chemokine (C-X-C motif) ligand 12	Mus musculus	105-134
30120407-11	2019	Brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), hepatocyte growth factor (HGF), and stromal cell-derived factor-1 (SDF-1) gene expressions in hAFS were elevated when exposed to HI-induced brain extract.	Histidine	198-200	chemokine (C-X-C motif) ligand 12	Mus musculus	136-141
30248342-10	2018	Heterozygous loss of the tumor-suppressor fragile histidine triad (FHIT) gene also was observed, although protein expression was preserved.	Histidine	50-59	fragile histidine triad diadenosine triphosphatase	Homo sapiens	67-71
30362736-6	2018	Among the nine methylation sites, we found that the extents of methylation were significantly higher in elderly subjects at the N-terminal and His-20 of alpha-globin, and at the N-terminal and Glu-26 of beta-globin.	Histidine	143-146	hemoglobin subunit alpha 2	Homo sapiens	153-165
30335802-1	2018	In eukaryotes, the modification of an invariant histidine (His-699 in yeast) residue in translation elongation factor 2 (EF2) with diphthamide involves a conserved pathway encoded by the DPH1-DPH7 gene network.	Histidine	48-57	2-(3-amino-3-carboxypropyl)histidine synthase	Saccharomyces cerevisiae S288C	187-191
30335802-1	2018	In eukaryotes, the modification of an invariant histidine (His-699 in yeast) residue in translation elongation factor 2 (EF2) with diphthamide involves a conserved pathway encoded by the DPH1-DPH7 gene network.	Histidine	59-62	2-(3-amino-3-carboxypropyl)histidine synthase	Saccharomyces cerevisiae S288C	187-191
30204443-3	2018	The Zn2+-induced difference ATR-FTIR spectra of Hv1 showed IR features that can be assigned to the histidine C5-N1 and carboxylate-COO- stretches as well as amide I changes likely in alpha-helical peptide bonds.	Histidine	99-108	hydrogen voltage gated channel 1	Homo sapiens	48-51
30031072-0	2018	Structural and functional changes in RNAse A originating from tyrosine and histidine cross-linking and oxidation induced by singlet oxygen and peroxyl radicals.	Histidine	75-84	ribonuclease A family member 1, pancreatic	Homo sapiens	37-44
30031072-5	2018	RNAse A lacks tryptophan and cysteine residues which are major oxidant targets, but contains multiple histidine, tyrosine and methionine residues; these were therefore hypothesized to be the major sites of damage.	Histidine	102-111	ribonuclease A family member 1, pancreatic	Homo sapiens	0-7
30132476-2	2018	Using model peptides, we elucidated both qualitative and quantitative aspects of the Ag+-induced alpha-helical structuring role of His- and Met-rich sequences of SilE, improving our understanding of its function within the Sil system.	Histidine	131-134	STIL centriolar assembly protein	Homo sapiens	162-165
30184506-0	2018	Histidine-Dependent Protein Methylation Is Required for Compartmentalization of CTP Synthase.	Histidine	0-9	CTP synthase 1	Homo sapiens	80-92
30184506-3	2018	Here, we provide evidence that CTPS forms filaments in response to histidine influx during glutamine starvation.	Histidine	67-76	CTP synthase 1	Homo sapiens	31-35
30184506-5	2018	CTPS protein levels remain stable in the presence of histidine during nutrient deprivation, followed by rapid cell growth after stress relief.	Histidine	53-62	CTP synthase 1	Homo sapiens	0-4
30184506-8	2018	CTPS filament formation induced by histidine-mediated methylation may be a strategy used by cancer cells to maintain homeostasis and ensure a growth advantage in adverse environments.	Histidine	35-44	CTP synthase 1	Homo sapiens	0-4
29903888-2	2018	SRSF2 mutations cluster at proline 95, with the most frequent mutation being a histidine (P95H) substitution.	Histidine	79-88	serine and arginine rich splicing factor 2	Homo sapiens	0-5
30135643-9	2018	Moreover, the histidine residue (His 470) of CPT1C is crucial for the increase in GluA1 surface expression in neurons and the H470A mutation impairs the depalmitoylating catalytic activity of CPT1C.	Histidine	14-23	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	82-87
30135643-9	2018	Moreover, the histidine residue (His 470) of CPT1C is crucial for the increase in GluA1 surface expression in neurons and the H470A mutation impairs the depalmitoylating catalytic activity of CPT1C.	Histidine	33-36	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	82-87
29863788-10	2018	We also used native and top-down MS to investigate the histidine autophosphorylation activity of purified Nm23 assemblies.	Histidine	55-64	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	106-110
29691140-4	2018	By using amine reactive fluorescent N-hydroxysuccinimidyl (NHS)-ester dyes and by direct detection with primary fluorescently conjugated anti-histidine (His-tag) antibodies against detect N-terminal His6, we show Eap subdomain Eap D3D4 specifically interacts and rapidly activates human platelets.	Histidine	142-151	glutamyl aminopeptidase	Homo sapiens	213-216
29743298-1	2018	The voltage sensor (VS) domain in Hv1 proton channels mediates a voltage-dependent and H+-selective "aqueous" conductance (GAQ) that is potently modulated by extracellular Zn2+ Although two conserved His residues are required for Zn2+ effects on GAQ gating, the atomic structure of the Zn2+ coordination site and mechanism by which extracellular Zn2+ stabilizes a closed-state conformation remain unknown.	Histidine	200-203	hydrogen voltage gated channel 1	Homo sapiens	34-37
29960902-7	2018	RESULTS: The real-time RT-PCR and DNA sequencing data for the identified genes indicated that the N-terminal domain-interacting receptor 1 (Nir1) gene was suppressed whereas Nir2 and fragile histidine triad (FHIT) genes were upregulated followed by the overexpression of TGIF2LX gene.	Histidine	191-200	fragile histidine triad diadenosine triphosphatase	Homo sapiens	208-212
29860820-1	2018	Objective: To explore the relationship between abnormal expression of fragile histidine triad (FHIT) gene and methyl-CpG-binding protein 2 (MeCP2) as well as their interaction on cervical cancerization.	Histidine	78-87	fragile histidine triad diadenosine triphosphatase	Homo sapiens	95-99
29717998-0	2018	In situ proteolysis of an N-terminal His tag with thrombin improves the diffraction quality of human aldo-keto reductase 1C3 crystals.	Histidine	37-40	aldo-keto reductase family 1 member C3	Homo sapiens	101-124
29481666-6	2018	In addition to the seven novel gene associations, we identified five independent signals at established amino acid loci, including two rare variant signals at GLDC (rs138640017, MAF=0.95%, Pconditional = 5.8x10-40) with glycine levels and HAL (rs141635447, MAF = 0.46%, Pconditional = 9.4x10-11) with histidine levels.	Histidine	301-310	glycine decarboxylase	Homo sapiens	159-163
28612701-6	2017	An analysis of publicly available neuraminidase gene sequences showed that viruses with histidine at position 150 were rapidly replaced by viruses with arginine at this position between 2005 and 2008, in agreement with the phenotypic data.	Histidine	88-97	neuraminidase 1	Homo sapiens	34-47
28566767-6	2017	The "His carrier" (His/His or His/Arg) of rs1229984 (His48Arg) of ADH1B significantly increased gout risk (P = 4.3 x 10-4, odds ratio = 1.76), as did the "non-Lys carrier (Glu/Glu)" of rs671 (Glu504Lys) of ALDH2.	Histidine	5-8	aldehyde dehydrogenase 2 family member	Homo sapiens	206-211
28566767-6	2017	The "His carrier" (His/His or His/Arg) of rs1229984 (His48Arg) of ADH1B significantly increased gout risk (P = 4.3 x 10-4, odds ratio = 1.76), as did the "non-Lys carrier (Glu/Glu)" of rs671 (Glu504Lys) of ALDH2.	Histidine	19-22	aldehyde dehydrogenase 2 family member	Homo sapiens	206-211
28566767-6	2017	The "His carrier" (His/His or His/Arg) of rs1229984 (His48Arg) of ADH1B significantly increased gout risk (P = 4.3 x 10-4, odds ratio = 1.76), as did the "non-Lys carrier (Glu/Glu)" of rs671 (Glu504Lys) of ALDH2.	Histidine	19-22	aldehyde dehydrogenase 2 family member	Homo sapiens	206-211
390308-3	1979	Diploids homozygous for the mutation are deficient in UV-induced recombination between the alleles his1-1 and hist1-315, mutation being sufficient to account for all the UV-induced histidine prototrophs.	Histidine	181-190	ATP phosphoribosyltransferase	Saccharomyces cerevisiae S288C	99-105
28232482-4	2017	This network, which involves residues Asp-222, His-143, Thr-139, His-189, and structural waters, is located at the edge of PLP opposite the reactive Schiff base.	Histidine	47-50	pyridoxal phosphatase	Homo sapiens	123-126
28232482-4	2017	This network, which involves residues Asp-222, His-143, Thr-139, His-189, and structural waters, is located at the edge of PLP opposite the reactive Schiff base.	Histidine	65-68	pyridoxal phosphatase	Homo sapiens	123-126
106925-3	1979	Chromatography of TRH-like immunoreactivity obtained from Rana pipiens skin eluted in two solvent systems produced elution profiles identical with that of synthetic Pyroglu-His-Pro-NH2 consistent with reports that frog skin contains large quantities of TRH.	Histidine	173-176	thyrotropin releasing hormone	Homo sapiens	18-21
28257787-8	2017	The importance of histidine-256 protonation states in distinct binding preferences of E2 were also demonstrated in hPDI red/ox conformations.	Histidine	18-27	prolyl 4-hydroxylase subunit beta	Homo sapiens	115-119
478976-0	1979	Hemoglobin Sunshine Seth - alpha 2 (94 (G1) Asp replaced by His) beta 2.	Histidine	60-63	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	65-71
43839-0	1979	Hydrogen-tritium exchange titration of the histidine residues in bovine heart cytochrome c and analysis of their microenvironment.	Histidine	43-52	LOC104968582	Bos taurus	78-90
28228363-1	2017	Histidine decarboxylase (HDC) is an enzyme that converts histidine to histamine.	Histidine	57-66	histidine decarboxylase	Homo sapiens	0-23
28228363-1	2017	Histidine decarboxylase (HDC) is an enzyme that converts histidine to histamine.	Histidine	57-66	histidine decarboxylase	Homo sapiens	25-28
28228363-2	2017	Inhibition of HDC has several medical applications, and HDC inhibitors are of considerable interest for the study of histidine metabolism.	Histidine	117-126	histidine decarboxylase	Homo sapiens	56-59
29414441-7	2018	Analysis of a PKCdelta structural model revealed a potential His-Cys3 zinc-binding domain adjacent to residue Thr505 and suggests that interaction with a Zn2+ ion may preclude phosphorylation at this site.	Histidine	61-64	protein kinase C delta	Homo sapiens	14-22
43839-1	1979	Microenvironments of the three histidine residues located at the positions 18, 26, and 33 from the amino terminus in bovine heart cytochrome c were analysed in solution by the hydrogen-tritium exchange titration method, which has been developed in this laboratory.	Histidine	31-40	LOC104968582	Bos taurus	130-142
27586957-5	2017	The probe pairs, designated as Trac-MTG (His-CerDelta11-LQ/EV-K-His) containing linker and substrate peptide sequence for microbial TG (MTG), increased the EVenus:Cerulean fluorescence intensity ratio by more than 1.5-fold.	Histidine	41-44	T cell receptor alpha constant	Homo sapiens	31-35
30487-0	1978	The involvement of one of the three histidine residues of cow kappa-casein in the chymosin-initiated milk clotting process.	Histidine	36-45	chymosin	Bos taurus	82-90
27586957-6	2017	Furthermore, we demonstrated that Trac-TG1 (His-CerDelta11-K5) and Trac-TG2 (His-CerDelta11-T26) containing substrate peptide sequence for mammalian TGs successfully detected the isozyme-specific activity of TG1 and TG2, respectively.	Histidine	44-47	T cell receptor alpha constant	Homo sapiens	34-38
27586957-6	2017	Furthermore, we demonstrated that Trac-TG1 (His-CerDelta11-K5) and Trac-TG2 (His-CerDelta11-T26) containing substrate peptide sequence for mammalian TGs successfully detected the isozyme-specific activity of TG1 and TG2, respectively.	Histidine	77-80	T cell receptor alpha constant	Homo sapiens	67-71
697840-0	1978	An essential histidine residue in the catalytic mechanism of mammalian glutathione reductase.	Histidine	13-22	glutathione-disulfide reductase	Homo sapiens	71-92
28451315-2	2017	In the case of Alcaligenes xylosoxidans cytochrome c" (AXCP), formation of a transient distal 6cNO complex is followed by scission of the trans Fe-His bond and conversion to a proximal 5cNO product via a putative dinitrosyl species.	Histidine	147-150	D-alanyl-D-alanine carboxypeptidase	Achromobacter xylosoxidans	40-52
29599797-4	2018	Here, we showed that AtROP6 specially bound to a phospholipid, phosphatidylglycerol (PG), by the protein-lipid overlay and liposome sedimentation assays, and further MST assay gave a dissociation constant (Kd) of 4.8 +- 0.4 muM for binding of PG to His-AtROP6.	Histidine	249-252	RAC-like 3	Arabidopsis thaliana	21-27
710366-4	1978	Our structure showed residues 80--84 to be -His-Cys-Ser-Thy-Cys-, consistent with findings of others for human follicle stimulating hormone (hFSH) and human chorionic gonadotropin (hCG).	Histidine	44-47	chorionic gonadotropin subunit beta 5	Homo sapiens	157-185
29058706-12	2018	It also summarizes why our understanding of phosphorylation is still largely restricted to the acid stable phosphoproteome, and highlights the study of NM23 histidine kinase as an entree into the world of histidine phosphorylation.	Histidine	157-166	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	152-156
29479880-6	2018	Furthermore, we found a mutation on exon 3 of the HPRT gene in the patient and his mother (exon 3: c.143G&gt;A), which resulted in arginine to histidine (p.R48H) substitution in the encoded protein.	Histidine	143-152	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	50-54
28204548-2	2017	It post-transcriptionally replaces guanine 34 in transfer RNA isoacceptors for Asp, Asn, His and Tyr, in almost all eukaryotic organisms, through the activity of the ancient tRNA guanine transglycosylase (TGT) enzyme.	Histidine	89-92	queuine tRNA-ribosyltransferase catalytic subunit 1	Mus musculus	174-203
28204548-2	2017	It post-transcriptionally replaces guanine 34 in transfer RNA isoacceptors for Asp, Asn, His and Tyr, in almost all eukaryotic organisms, through the activity of the ancient tRNA guanine transglycosylase (TGT) enzyme.	Histidine	89-92	queuine tRNA-ribosyltransferase catalytic subunit 1	Mus musculus	205-208
894608-4	1977	Kinetic analysis of enzyme-catalysed histidine decarboxylation in extracts from untreated vagotomized and from histamine-treated vagotomized rats showed that the histamine-induced suppression of histidine decarboxylase activity probably reflects a reduced enzyme concentration.	Histidine	37-46	histidine decarboxylase	Rattus norvegicus	195-218
27865700-8	2017	A shift in pH, altering the protonation state of the central histidine residue impairs the adhesion of Ang II.	Histidine	61-70	angiogenin	Homo sapiens	103-106
29535799-0	2018	The relationship of NM23 (NME) metastasis suppressor histidine phosphorylation to its nucleoside diphosphate kinase, histidine protein kinase and motility suppression activities.	Histidine	53-62	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	20-24
29535799-7	2018	Site-directed mutagenesis of NME1 histidine 118 and proline 96 was examined by transfection experiments and partial purification of recombinant proteins.	Histidine	34-43	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	29-33
330813-2	1977	Therefore these hybrids must have inherited the his-linked donor rfb region determining the synthesis of O8- specific polysaccharides as well as his-linked genes involved in K27 antigen synthesis.	Histidine	145-148	keratin 27	Homo sapiens	174-177
29232843-1	2017	The decapeptide gonadotropin-releasing hormone, also referred to as luteinizing hormone-releasing hormone with the sequence (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2) plays an important role in regulating the reproductive system.	Histidine	130-133	gonadotropin releasing hormone 1	Homo sapiens	16-46
27469131-7	2017	RESULTS: WES demonstrated a homozygous novel missense ASNS mutation, c.1019G &gt; A, resulting in substitution of the highly conserved arginine residue by histidine (R340H).	Histidine	155-164	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	54-58
850236-2	1977	Twenty-eight derivatives of histidine were tested as inhibitors of histidine decarboxylase from rat stomach.	Histidine	28-37	histidine decarboxylase	Rattus norvegicus	67-90
27860077-1	2016	Histamine, a classic low-molecular-weight amine, is synthesized from L-histidine by histidine decarboxylase (HDC), and histamine-specific receptors (HRs) are essential for its actions.	Histidine	69-80	histidine decarboxylase	Mus musculus	84-107
27860077-1	2016	Histamine, a classic low-molecular-weight amine, is synthesized from L-histidine by histidine decarboxylase (HDC), and histamine-specific receptors (HRs) are essential for its actions.	Histidine	69-80	histidine decarboxylase	Mus musculus	109-112
29031033-8	2017	An RNA-protein interaction assay showed that the histidine-tagged recombinant APUM24 binds RNAin vitro with no apparent specificity.	Histidine	49-58	pumilio 24	Arabidopsis thaliana	78-84
132446-9	1976	A decrease of the Ca2+-dependent ATPase activity correlated with the inhibition of both VCa and Cca corresponds to the chemical substitution of the histidine.	Histidine	148-157	dynein axonemal heavy chain 8	Homo sapiens	33-39
28969870-1	2017	SAMHD1 (sterile alpha motif and histidine (H) aspartate (D) domain-containing protein 1) is known for its antiviral activity of hydrolysing deoxynucleotides required for virus replication.	Histidine	32-41	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
27707927-7	2016	The histidine, aspartic acid, and serine residue (HDS) triad of TMPRSS12 was shown to be essential for the proteolysis of aMPV/B F protein via mutation analysis.	Histidine	4-13	transmembrane serine protease 12	Homo sapiens	64-72
132446-11	1976	After removing the ethoxyformyl group from the histidine, only the Ca2+-dependent ATPase activity is restored to its initial value.	Histidine	47-56	dynein axonemal heavy chain 8	Homo sapiens	82-88
238843-7	1975	Titration curves for the H-2 proton resonances of histidine-12 and histidine-119 of methylated RNase-A show deviations from the titration curves for the native enzyme, indicating some alteration of the active-site conformation.	Histidine	50-59	ribonuclease A family member 1, pancreatic	Homo sapiens	95-102
28724665-4	2017	Tumor-associated macrophages in surgical specimens and sensitivity to CSF-1R inhibitors were used to determine macrophage function.Results: A CSF1R c.1085A&gt;G genetic variant causing the change of histidine to arginine in the domain of receptor dimerization was identified as a high allele frequency in Eastern Asian population.	Histidine	199-208	colony stimulating factor 1 receptor	Homo sapiens	70-76
27819327-8	2016	Site-directed mutagenesis experiments have implicated a basic surface including the side chains of Arg 6, His 11 and Lys 32 as potentially important in the FS50 NaV1.5 interaction.	Histidine	106-109	sodium voltage-gated channel alpha subunit 5	Rattus norvegicus	161-167
28579117-2	2017	The core sequence of NDP-alpha-MSH, His-Phe-Arg-Trp, is important for ligand binding and biological activities at the melanocortin receptor subtypes (MCRs).	Histidine	36-39	norrin cystine knot growth factor NDP	Homo sapiens	21-24
238843-7	1975	Titration curves for the H-2 proton resonances of histidine-12 and histidine-119 of methylated RNase-A show deviations from the titration curves for the native enzyme, indicating some alteration of the active-site conformation.	Histidine	67-76	ribonuclease A family member 1, pancreatic	Homo sapiens	95-102
238843-8	1975	In the presence of phosphate, titration curves for the H-2 proton resonances of histidine-12 and histidine-119 of methylated RNase-A indicate binding of phosphate at the active site, but these curves continue to show deviations from the titration behaviour of native RNase-A.	Histidine	80-89	ribonuclease A family member 1, pancreatic	Homo sapiens	125-132
1122293-8	1975	Of the basic amino acids platelet factor 4 (molecular weight 27 100) contained 5.97% arginine, 3.18% histidine, and 12.31% lysine compared to protamine sulphate with 64.2% arginine, 0.6% lysine and no histidine.	Histidine	101-110	platelet factor 4	Homo sapiens	25-42
28755312-2	2017	Due to the persistent insolubility of the recombinant product expressed in Escherichia coli, active mouse Nudt13 was expressed in insect cells from a baculovirus vector as a histidine-tagged recombinant protein.	Histidine	174-183	nudix (nucleoside diphosphate linked moiety X)-type motif 13	Mus musculus	106-112
27807034-4	2016	CNOT3 interacts with EBF1, and we identified histidine 240 in EBF1 as a critical residue for this interaction.	Histidine	45-54	CCR4-NOT transcription complex, subunit 3	Mus musculus	0-5
4430367-0	1974	A resonance Raman study on Hb M Iwate (alpha87His leads to Tyr beta)2, and Hb Zurich (alpha beta 63 His-Arg).	Histidine	46-49	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	63-69
27543005-10	2016	Conversely, we demonstrate that several amino acid substitutions (including His, Phe, Pro, Trp, and Tyr) support an enhanced viability during oxidative stress associated with oxidized Kar2, although these alleles are compromised as an ATPase.	Histidine	76-79	Hsp70 family ATPase KAR2	Saccharomyces cerevisiae S288C	184-188
27588835-1	2016	The sterile alpha motif (SAM) and histidine-aspartate (HD) domain containing protein 1 (SAMHD1) constitute a triphosphohydrolase that converts deoxyribonucleoside triphosphates (dNTPs) into deoxyribonucleosides and triphosphates.	Histidine	34-43	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	88-94
28404875-1	2017	Inactivation of the fragile histidine triad (Fhit) gene has been reported in the majority of human cancers, particularly in lung cancer.	Histidine	28-37	fragile histidine triad diadenosine triphosphatase	Homo sapiens	45-49
28082676-5	2017	Miner2 contains two CDGSH motifs, and each CDGSH motif hosts a [2Fe-2S] cluster via three cysteine and one histidine residues.	Histidine	107-116	CDGSH iron sulfur domain 3	Homo sapiens	0-6
28382155-3	2017	Lactam bridge-cyclized alpha-melanocyte-stimulating hormone (Ac-Nle4-cyclo[Asp5-His-D-Phe7-Arg-Trp-Lys10]-NH2, or Nle-CycMSHhex) analogues have been successfully developed and studied for MC1R-targeted imaging, predominantly with single-photon emission computed tomography (SPECT).	Histidine	80-83	pro-opiomelanocortin-alpha	Mus musculus	23-59
5144756-2	1971	Both growth hormone and insulin, when present in the medium separately, stimulated the incorporation into protein of the amino acids, leucine, arginine, valine, lysine and histidine.	Histidine	172-181	insulin	Oryctolagus cuniculus	24-31
4995924-4	1971	With the use of synthetic thyrotropin-releasing hormone, detected by the Pauly reagent or with (125)1-labeled thyrotropin-releasing hormone as a marker, thin-layer chromatograms, paper electrophoresis, and carboxymethyl cellulose ion exchange chromatography revealed that only proline, histidine, and glutamic acid were consistently incorporated into peptides associated with the thyrotropin-releasing hormone region.	Histidine	286-295	thyrotropin releasing hormone	Rattus norvegicus	26-55
28035416-5	2017	During pull-down experiments GST-pallidin was able to bind His-Ndn (an HDAC3 binding protein) in vitro.	Histidine	59-62	necdin, MAGE family member	Homo sapiens	63-66
28035416-5	2017	During pull-down experiments GST-pallidin was able to bind His-Ndn (an HDAC3 binding protein) in vitro.	Histidine	59-62	histone deacetylase 3	Homo sapiens	71-76
4989588-0	1970	Metabolism of histidine in x-irradiated rats in relation to histamine and diamine oxidase.	Histidine	14-23	amine oxidase, copper containing 1	Rattus norvegicus	74-89
27225845-0	2016	Hb Grifton [alpha87(F8)His Pro; HBA1: C.263A &gt; C (or HBA2)] Causes Abnormal Pulse Oximetry Measurements.	Histidine	23-26	hemoglobin subunit alpha 1	Homo sapiens	32-36
27976903-7	2017	A 23mer His-based peptide derived from human fatty acyl-CoA reductase 1 in complex with heme exhibited a significantly higher peroxidase activity than Abeta(40)-heme.	Histidine	8-11	fatty acyl-CoA reductase 1	Homo sapiens	45-71
33950219-6	2021	In addition, the presence of magnesium ions was shown to significantly increase the activity for the natural substrate retinal of RALDH3 but not the others, while His-tag cleavage considerably increased the activity of ALDH2 for the non-specific substrate retinal.	Histidine	163-166	aldehyde dehydrogenase 2 family member	Homo sapiens	219-224
27815796-7	2017	The AV interval (P &lt; 0.01) and the His-CS delay (P &lt; 0.001) were negatively and positively correlated, respectively, with the BNP level.	Histidine	38-41	natriuretic peptide B	Homo sapiens	132-135
27235274-4	2016	This behavior is attributed to the tetrahedral coordination geometry supported by the tris(histidine) unit (His3) of CA.	Histidine	91-100	carbonic anhydrase 2	Bos taurus	117-119
33904715-5	2021	Three histidine residues located around the ApA binding site were identified as labeling sites by liquid chromatography-mass spectrometry analysis.	Histidine	6-15	glutamyl aminopeptidase	Homo sapiens	44-47
27346116-1	2016	OBJECTIVE: To investigate the association between fragile histidine triad (FHIT) gene methylation, abnormal protein expression and HPV16 infection as well as their interactions in cervical carcinogenesis.	Histidine	58-67	fragile histidine triad diadenosine triphosphatase	Homo sapiens	75-79
27917477-6	2017	Putative Zn2+ -binding motifs within SV31 comprise aspartic acid and histidine residues.	Histidine	69-78	transmembrane protein 163	Homo sapiens	37-41
34021366-1	2021	We have generated a mutant of C. elegans manganese superoxide dismutase at histidine 30 by site-directed mutagenesis.	Histidine	75-84	superoxide dismutase 2	Homo sapiens	41-71
28361593-2	2016	The following is the first report of a double heterozygosity for Hb Q-Thailand [alpha74(EF3)Asp His; HBA1: c.223G&gt;C] with alpha+-thalassemia (alpha+-thal) and Hb J-Bangkok [beta56(D7)Gly Asp; HBB: c.170G&gt;A] found in a Chinese family.	Histidine	96-99	hemoglobin subunit alpha 1	Homo sapiens	101-105
27109476-4	2016	The structure confirm that MES16 is a member of the alpha/beta-hydrolase superfamily with Ser-87, His-239, and Asp-211 as the catalytic triad.	Histidine	98-101	methyl esterase 16	Arabidopsis thaliana	27-32
33957043-3	2021	Electron-rich histidine acted as a Lewis base effectively immobilizing Co2+ (Lewis acid) via the electrostatic effect and hydrogen bonds, thus achieving the scalable synthesis of Co-SAs-HCS.	Histidine	14-23	holocarboxylase synthetase	Homo sapiens	186-189
26429810-3	2016	Irx3/IRX3 encodes a transcription factor specifically expressed in the His-Purkinje system in the heart.	Histidine	71-74	Iroquois related homeobox 3	Mus musculus	0-4
26429810-3	2016	Irx3/IRX3 encodes a transcription factor specifically expressed in the His-Purkinje system in the heart.	Histidine	71-74	Iroquois related homeobox 3	Mus musculus	5-9
27605678-2	2016	A unique histidine triad on the surface of the receptor-binding domain from the glycoprotein spike complex of Lassa virus is important for LAMP1 binding.	Histidine	9-18	lysosomal associated membrane protein 1	Homo sapiens	139-144
27605678-3	2016	Here we investigate mutated spikes that have an impaired ability to interact with LAMP1 and show that although LAMP1 is important for efficient infectivity, it is not required for spike-mediated membrane fusion per se Our studies reveal important regulatory roles for histidines from the triad in sensing acidic pH and preventing premature spike triggering.	Histidine	268-278	lysosomal associated membrane protein 1	Homo sapiens	111-116
33967989-5	2021	The UBC9-UL44 interaction was confirmed by in vitro His-tag pull-down and in vivo co-immunoprecipitation assays.	Histidine	52-55	ubiquitin conjugating enzyme E2 I	Homo sapiens	4-8
27487322-5	2016	We found that the intrahelical hydrogen bond formed by the T202 hydroxyl group in the C-terminal zinc finger of TIS11d is necessary to allow for pi-pi stacking between the side chains of a conserved phenylalanine and the zinc-coordinating histidine.	Histidine	239-248	ZFP36 ring finger protein like 2	Homo sapiens	112-118
29997800-0	2016	Remarkably selective and enantiodifferentiating sensing of histidine by a fluorescent homochiral Zn-MOF based on pyrene-tetralactic acid.	Histidine	59-68	lysine acetyltransferase 8	Homo sapiens	100-103
26367539-4	2016	We further demonstrate that marked selectivity for the second over the first bromodomain can be achieved with an indole derivative that exploits differential interaction with an aspartate/histidine conservative substitution on the BC loop of BET bromodomains.	Histidine	188-197	delta/notch like EGF repeat containing	Homo sapiens	242-245
27716783-2	2016	In this study, we first expressed mouse mature Chit1 fused with V5 and (His)6 tags at the C-terminus (Chit1-V5-His) in the cytoplasm of Escherichia coli and found that most of the expressed protein was insoluble.	Histidine	72-75	chitinase 1 (chitotriosidase)	Mus musculus	47-52
27716783-3	2016	In contrast, Chit1 tagged with Protein A at the N-terminus and V5-His at the C-terminus, was expressed in the periplasmic space of E. coli as a soluble protein and successfully purified.	Histidine	66-69	chitinase 1 (chitotriosidase)	Mus musculus	13-18
33967989-5	2021	The UBC9-UL44 interaction was confirmed by in vitro His-tag pull-down and in vivo co-immunoprecipitation assays.	Histidine	52-55	DNA polymerase processivity subunit	Human betaherpesvirus 5	9-13
33576020-6	2021	In cultured HSCs, extracellular His-CYGB was endocytosed and accumulated in endosomes via clathrin-mediated pathway.	Histidine	32-35	cytoglobin	Mus musculus	36-40
27373844-7	2016	We also identified a region of MGAT2 associated with the ER membrane that contains the histidine-proline-histidine-glycine sequence present in all DGAT2 family members that is thought to comprise the active site.	Histidine	87-96	alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Homo sapiens	31-36
33576020-14	2021	His-CYGB exhibited no toxicity in humanised liver chimeric PXB mice.	Histidine	0-3	cytoglobin	Mus musculus	4-8
33514426-7	2021	Our study also revealed that HLA-DRB1 amino acid at position 96 with histidine residue was negatively associated with the risk of developing ACPA-positive RA in the Indians (OR = 0.48, 95% CI = 0.37-0.62, PGWAS = 2.58 x 10-08).	Histidine	69-78	proteinase 3	Homo sapiens	141-145
33428390-0	2021	Asymmetric Roles of Two Histidine Residues in Streptococcus pyogenes Cas9 Catalytic Domains upon Chemical Rescue.	Histidine	24-33	type II CRISPR RNA-guided endonuclease Cas9	Streptococcus pyogenes	69-73
27624082-1	2016	We present a case of a novel pathogenic variant, Hb Kalavasos [alpha91(FG3)Leu His (alpha2); HBA2: c.275T &gt; A; p.Leu92His (NM_000517.4)]; this codon was previously numbered 91 on the alpha2-globin gene that was discovered following routine Hb A1c testing on a 65-year-old female of Cypriot origin.	Histidine	79-82	hemoglobin subunit alpha 2	Homo sapiens	93-97
27624082-1	2016	We present a case of a novel pathogenic variant, Hb Kalavasos [alpha91(FG3)Leu His (alpha2); HBA2: c.275T &gt; A; p.Leu92His (NM_000517.4)]; this codon was previously numbered 91 on the alpha2-globin gene that was discovered following routine Hb A1c testing on a 65-year-old female of Cypriot origin.	Histidine	79-82	hemoglobin subunit alpha 2	Homo sapiens	186-199
26876430-3	2016	Next, we summarize the post-transcriptional mechanisms that regulate the expression of IF1 and emphasize, in addition to the regulation afforded by the protonation state of histidine residues, that the activity of IF1 as an inhibitor of the ATP synthase is also regulated by phosphorylation of a serine residue.	Histidine	173-182	ATP synthase inhibitory factor subunit 1	Homo sapiens	214-217
26657863-6	2016	Progesterone receptor membrane component-1 (PGRMC1) was required for HIS-dependent increases in hepcidin biosynthesis, as PGRMC1 depletion in cultured hepatoma cells and zebrafish blocked the ability of HISs to increase hepcidin mRNA levels.	Histidine	69-72	progesterone receptor membrane component 1	Danio rerio	0-42
26657863-6	2016	Progesterone receptor membrane component-1 (PGRMC1) was required for HIS-dependent increases in hepcidin biosynthesis, as PGRMC1 depletion in cultured hepatoma cells and zebrafish blocked the ability of HISs to increase hepcidin mRNA levels.	Histidine	69-72	progesterone receptor membrane component 1	Danio rerio	44-50
27096786-4	2016	Expression of histidine-tagged pK205R with a molecular mass of 44 kDa was determined by 12% sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and Western blot analysis.	Histidine	14-23	pK205R	African swine fever virus	31-37
33167279-6	2021	The immobilized peptide would be cleavaged by proteinase K, then the His-tag residue part will leave the surface of Au film, resulting less His-tag could bind to Ni2+ and a small SPR signal would be record.	Histidine	140-143	sepiapterin reductase	Homo sapiens	179-182
33167279-8	2021	Then more His-tag can be left on the Au film and a bigger SPR signal could be record, this signal is associated with the concentration of OGT.	Histidine	10-13	sepiapterin reductase	Homo sapiens	58-61
33425909-1	2020	Human tyrosyl-DNA phosphodiesterase 1 (TDP1) belongs to the phospholipase D superfamily, whose members contain paired catalytic histidine and lysine residues within two conserved motifs and hydrolyze phosphodiester bonds.	Histidine	128-137	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	6-37
26597768-4	2015	Classically the alphavirus nsP2 protease is thought to be papain-like with the enzyme reaction proceeding through a cysteine/histidine catalytic dyad.	Histidine	125-134	reticulon 2	Homo sapiens	27-31
27135265-4	2016	All the melanocortin agonists derived from the POMC prohormone contain a His-Phe-Arg-Trp tetrapeptide sequence that has been implicated in eliciting the pharmacological responses at the melanocortin receptors.	Histidine	73-76	pro-opiomelanocortin-alpha	Mus musculus	47-51
33425909-1	2020	Human tyrosyl-DNA phosphodiesterase 1 (TDP1) belongs to the phospholipase D superfamily, whose members contain paired catalytic histidine and lysine residues within two conserved motifs and hydrolyze phosphodiester bonds.	Histidine	128-137	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	39-43
33425909-3	2020	TDP1 hydrolyzes DNA-adducts via two coordinated SN2 nucleophilic attacks mediated by the action of two histidine residues and leads to the formation of the covalent intermediate.	Histidine	103-112	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	0-4
28164627-1	2016	BACKGROUND: Fragile histidine triad (FHIT), fibronectin (FN), and phosphatase and tensin homology deleted on chromosome ten (PTEN) are widely reported as having abnormal expression in malignant tumors.	Histidine	20-29	fragile histidine triad diadenosine triphosphatase	Homo sapiens	37-41
33261109-0	2020	Anti-Allergic Potential of Cinnamaldehyde via the Inhibitory Effect of Histidine Decarboxylase (HDC) Producing Klebsiella pneumonia.	Histidine	71-80	histidine decarboxylase	Homo sapiens	96-99
25957834-1	2015	A novel multifunctional peptide fluorescent chemosensor (DP-3) with a lysine backbone and double sides conjugated with histidine and dansyl groups has been designed and synthesized by solid phase synthesis.	Histidine	119-128	APC regulator of WNT signaling pathway	Homo sapiens	57-61
27560991-9	2016	Among the amino acids tested (all in L configuration), arginine, lysine, tryptophan and histidine enhanced residual activity of rCA1 and rCA4.	Histidine	88-97	carbonic anhydrase 4	Rattus norvegicus	137-141
32919067-7	2020	From analyses of spike protein sequences we identify patches of histidine and carboxylate groups that could be involved in transient proton binding.	Histidine	64-73	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	17-22
27332127-6	2016	The substitution of hydrophobic Ala with His or Arg in the central region of the EDEM1 or SPAST peptides, respectively, attenuated their ability to flip phospholipids.	Histidine	41-44	spastin	Homo sapiens	90-95
27239044-4	2016	Histamine reduction is most likely caused by increased catabolism of the histamine precursor histidine, triggered by rerouting of alanine flux from AGT to the glutamic-pyruvate transaminase (GPT, also known as the alanine-transaminase ALT).	Histidine	93-102	glutamic--pyruvic transaminase	Homo sapiens	159-189
27239044-4	2016	Histamine reduction is most likely caused by increased catabolism of the histamine precursor histidine, triggered by rerouting of alanine flux from AGT to the glutamic-pyruvate transaminase (GPT, also known as the alanine-transaminase ALT).	Histidine	93-102	glutamic--pyruvic transaminase	Homo sapiens	191-194
27251136-8	2016	S100A8 binds two zinc ions per homodimer, through two symmetrical, all-His tetracoordination sites, revealing a classical His-Zn binding mode for the protein.	Histidine	71-74	S100 calcium binding protein A8	Homo sapiens	0-6
27251136-8	2016	S100A8 binds two zinc ions per homodimer, through two symmetrical, all-His tetracoordination sites, revealing a classical His-Zn binding mode for the protein.	Histidine	122-125	S100 calcium binding protein A8	Homo sapiens	0-6
27251136-11	2016	CONCLUSIONS: Our structures of Zn(2+)/Ca(2+)-bound hS100A8 demonstrate that S100A8 is a genuine His-Zn S100 protein.	Histidine	96-99	S100 calcium binding protein A8	Homo sapiens	51-58
26457514-3	2015	In this study, the RAB11(S20V) mutant was overexpressed in Escherichia coli with an engineered C-terminal His tag.	Histidine	106-109	RAB11A, member RAS oncogene family	Homo sapiens	19-23
25964046-2	2015	Our N-glycoclusters, which were efficiently prepared by immobilizing 16 molecules of the asparagine-linked glycans (N-glycans) onto a lysine-based dendron template through histidine-mediated Huisgen cycloaddition, were shown to efficiently detect platelet endothelial cell adhesion molecule (PECAM) on human umbilical vein endothelial cells (HUVEC) as a alpha(2-6)-sialylated oligosaccharides recognizing lectin.	Histidine	172-181	platelet and endothelial cell adhesion molecule 1	Homo sapiens	247-290
25964046-2	2015	Our N-glycoclusters, which were efficiently prepared by immobilizing 16 molecules of the asparagine-linked glycans (N-glycans) onto a lysine-based dendron template through histidine-mediated Huisgen cycloaddition, were shown to efficiently detect platelet endothelial cell adhesion molecule (PECAM) on human umbilical vein endothelial cells (HUVEC) as a alpha(2-6)-sialylated oligosaccharides recognizing lectin.	Histidine	172-181	platelet and endothelial cell adhesion molecule 1	Homo sapiens	292-297
27251136-11	2016	CONCLUSIONS: Our structures of Zn(2+)/Ca(2+)-bound hS100A8 demonstrate that S100A8 is a genuine His-Zn S100 protein.	Histidine	96-99	S100 calcium binding protein A8	Homo sapiens	52-58
32871134-4	2020	In this study, we demonstrated that a HDC Y334F mutant is capable of catalyzing the decarboxylation-dependent oxidative deamination of histidine to yield imidazole acetaldehyde.	Histidine	135-144	histidine decarboxylase	Homo sapiens	38-41
26711783-1	2016	Carbonic anhydrase 8 (CA8), a member of the carbonic anhydrase family, is one of the three isozymes that do not catalyze the reversible hydration of carbon dioxide due to the lack of one important histidine.	Histidine	197-206	carbonic anhydrase 8	Homo sapiens	0-20
26195630-7	2015	Furthermore, when C-terminally fused to an ACE2 transmembrane anchor, the secretory N-terminal catalytic or hinge-cysteine-histidine-rich domain domains of PCSK9 were able to reduce CD81 and LDLR levels.	Histidine	123-132	angiotensin converting enzyme 2	Homo sapiens	43-47
26711783-1	2016	Carbonic anhydrase 8 (CA8), a member of the carbonic anhydrase family, is one of the three isozymes that do not catalyze the reversible hydration of carbon dioxide due to the lack of one important histidine.	Histidine	197-206	carbonic anhydrase 8	Homo sapiens	22-25
32888909-8	2020	Noteworthy, most modifications were observed at Lys and His residues located at A-site (K73, K87, K88), L-site (H26, H33, and K27) membrane binding sites.	Histidine	56-59	keratin 27	Homo sapiens	126-129
26721804-3	2016	To investigate the possible mechanism of this signaling defect at genetic level, single-nucleotide polymorphism (SNP) [His 1085 C/T] at the exon 17 of insulin receptor gene (INSR) was studied in this pilot study.	Histidine	119-122	insulin receptor	Homo sapiens	151-167
26263392-3	2015	We previously demonstrated that NCL changes its action on the human sweet receptor hT1R2-hT1R3 from antagonism to agonism as the pH changes from neutral to acidic values, and that the histidine residues of NCL molecule play critical roles in this pH-dependent functional change.	Histidine	184-193	taste 1 receptor member 3	Homo sapiens	89-94
33075108-8	2020	The results showed that 2280 His-p30 could directly degrade IFNAR1 RNA but not IFNAR2 RNA.	Histidine	29-32	centromere protein V	Homo sapiens	33-36
25888783-4	2015	The results showed that the pET-BLG-LFN and pET-BLG-RFN prokaryotic expression plasmids can be constructed correctly and expressed efficiently in Escherichia coli BL21 (DE3) cells to produce the 6x His-tagged ZFN proteins that can be purified by Ni-IDA-Sefinose Column.	Histidine	198-201	beta-lactoglobulin	Capra hircus	48-51
26721804-3	2016	To investigate the possible mechanism of this signaling defect at genetic level, single-nucleotide polymorphism (SNP) [His 1085 C/T] at the exon 17 of insulin receptor gene (INSR) was studied in this pilot study.	Histidine	119-122	insulin receptor	Homo sapiens	174-178
26777153-2	2016	A number of studies have been focused on His(18), the only histidine of hIAPP, whose imidazole ring and the protonation state might impact hIAPP amyloid formation, but the exact mechanism remains unclear.	Histidine	41-44	islet amyloid polypeptide	Homo sapiens	72-77
26777153-2	2016	A number of studies have been focused on His(18), the only histidine of hIAPP, whose imidazole ring and the protonation state might impact hIAPP amyloid formation, but the exact mechanism remains unclear.	Histidine	41-44	islet amyloid polypeptide	Homo sapiens	139-144
33046741-6	2020	Our results demonstrated that shorter and stricter reaction time was critical to approach the initial rate of NAD+-dependent desuccinylation activity in crude cell lysate systems, as compared to the desuccinylation reaction of purified His-SIRT5.	Histidine	236-239	sirtuin 5	Homo sapiens	240-245
26777153-2	2016	A number of studies have been focused on His(18), the only histidine of hIAPP, whose imidazole ring and the protonation state might impact hIAPP amyloid formation, but the exact mechanism remains unclear.	Histidine	59-68	islet amyloid polypeptide	Homo sapiens	72-77
26777153-5	2016	RESULTS: After an ethyl-acetate group was introduced to the His(18) of hIAPP by diethylpyrocarbonate (DEPC) modification, the pH dependent hIAPP fibrillation went to the opposite order and the number of intra-molecular hydrogen bonds decreased, while the possibility of His(18) participating in the formation of alpha-helical structures increased.	Histidine	60-63	islet amyloid polypeptide	Homo sapiens	71-76
26777153-7	2016	CONCLUSIONS: The intramolecular hydrogen bond formation by His(18) and the possibility of His(18) participating in the formation of alpha-helical structures greatly modulated the manner of hIAPP amyloid formation.	Histidine	59-62	islet amyloid polypeptide	Homo sapiens	189-194
26777153-7	2016	CONCLUSIONS: The intramolecular hydrogen bond formation by His(18) and the possibility of His(18) participating in the formation of alpha-helical structures greatly modulated the manner of hIAPP amyloid formation.	Histidine	90-93	islet amyloid polypeptide	Homo sapiens	189-194
26200004-3	2015	(2015) show that a histidine residue in the RNA binding pocket of RIG-I sterically excludes the cap1 structure of self RNA, thereby preventing downstream activation.	Histidine	19-28	cyclase associated actin cytoskeleton regulatory protein 1	Homo sapiens	96-100
26185440-0	2015	Inhibition of myeloid differentiation factor 88 signaling mediated by histidine-grafted poly(beta-amino ester) ester nanovector induces donor-specific liver allograft tolerance.	Histidine	70-79	MYD88 innate immune signal transduction adaptor	Homo sapiens	14-47
32658257-2	2020	Of these, the highly prevalent FcgammaRIIa (CD32a) histidine (H)-131 variant (CD32aH) is strongly linked to human autoimmune diseases through unclear mechanisms.	Histidine	51-60	Fc gamma receptor IIa	Homo sapiens	31-42
26185440-3	2015	We designed and synthesized a novel histidine-grafted poly(beta-amino ester) (HGPAE) nanovector, which was shown to be safe and efficient both in vitro and in vivo for the delivery of a plasmid containing shRNA targeting MyD88 (pMyD88).	Histidine	36-45	MYD88 innate immune signal transduction adaptor	Homo sapiens	221-226
26275700-5	2015	Injection of chemokines in the rat skin provoke the recruitment of inflammatory cells, release of cytokines, and activation of transcription of histidine decarboxylase (HDC), the enzyme responsible for the generation of histamine from histidine, which may cause fatal anaphylactic shock.	Histidine	144-153	histidine decarboxylase	Rattus norvegicus	169-172
26940498-7	2016	The conversion of His residues to Ala in AtHIRD11 resulted in the loss of the Cu(2+) binding of the protein as well as the disappearance of the conformational change induced by Cu(2+) that is observed by circular dichroism spectroscopy.	Histidine	18-21	dehydrin family protein	Arabidopsis thaliana	41-49
26940498-9	2016	These results indicate that AtHIRD11 can reactivate LDH inhibited by Cu(2+) via the His residues.	Histidine	84-87	dehydrin family protein	Arabidopsis thaliana	28-36
26854379-0	2016	Synthesis and biology of ring-modified l-Histidine containing thyrotropin-releasing hormone (TRH) analogues.	Histidine	39-50	thyrotropin releasing hormone	Homo sapiens	62-91
26854379-0	2016	Synthesis and biology of ring-modified l-Histidine containing thyrotropin-releasing hormone (TRH) analogues.	Histidine	39-50	thyrotropin releasing hormone	Homo sapiens	93-96
26854379-1	2016	Thyrotropin-releasing hormone (TRH) analogues bearing halogen groups (Cl, Br and I) at the C-2 and/or C-5 position, and the alkyl group (CH3, C2H5, C3H7, CH2C6H5) at the N-1 position of the imidazole ring of the central histidine residue were synthesized and evaluated for the receptor binding, calcium mobilization (FLIPR), and IP-1 assay at the HEK mTRHR1 and HEK mTRHR2 expressing cell lines.	Histidine	220-229	thyrotropin releasing hormone	Homo sapiens	0-29
32658257-2	2020	Of these, the highly prevalent FcgammaRIIa (CD32a) histidine (H)-131 variant (CD32aH) is strongly linked to human autoimmune diseases through unclear mechanisms.	Histidine	51-60	Fc gamma receptor IIa	Homo sapiens	44-49
26854379-1	2016	Thyrotropin-releasing hormone (TRH) analogues bearing halogen groups (Cl, Br and I) at the C-2 and/or C-5 position, and the alkyl group (CH3, C2H5, C3H7, CH2C6H5) at the N-1 position of the imidazole ring of the central histidine residue were synthesized and evaluated for the receptor binding, calcium mobilization (FLIPR), and IP-1 assay at the HEK mTRHR1 and HEK mTRHR2 expressing cell lines.	Histidine	220-229	thyrotropin releasing hormone	Homo sapiens	31-34
32472731-5	2020	MK-STYX (MAPK phosphoserine/threonine/tyrosine-binding protein) is a member of the MKP subfamily, which lacks the critical histidine and nucleophilic cysteine residues in the active site required for catalysis.	Histidine	123-132	serine/threonine/tyrosine interacting like 1	Homo sapiens	0-7
26841310-6	2016	Our spectroscopic studies suggest that TsrM binds cobalamin in an uncharacteristic five-coordinate base-off/His-off conformation, whereby the dimethylbenzimidazole group is replaced by a non-nitrogenous ligand, which is likely a water molecule.	Histidine	108-111	TSRM	Homo sapiens	39-43
26171037-1	2015	High-risk human papillomavirus (HPV)16/18 infection in the development of lung cancer has previously been identified, and fragile histidine triad (FHIT) loss and p53 mutation are frequently observed in the disease.	Histidine	130-139	fragile histidine triad diadenosine triphosphatase	Homo sapiens	147-151
32522573-2	2020	Brain histamine is synthesized from an essential amino acid histidine in a reaction catalysed by histidine decarboxylase (Hdc).	Histidine	60-69	histidine decarboxylase	Mus musculus	97-120
25573590-9	2015	Compared with subjects having ALDH-2 Lys+ with ADH-1B His/His, ORs and 95%CIs for those with ALDH-2 Glu/Glu and ADH-1B His/His was 3.42(0.57-20.38).	Histidine	54-57	aldehyde dehydrogenase 2 family member	Homo sapiens	30-36
25573590-9	2015	Compared with subjects having ALDH-2 Lys+ with ADH-1B His/His, ORs and 95%CIs for those with ALDH-2 Glu/Glu and ADH-1B His/His was 3.42(0.57-20.38).	Histidine	54-57	aldehyde dehydrogenase 2 family member	Homo sapiens	93-99
25573590-9	2015	Compared with subjects having ALDH-2 Lys+ with ADH-1B His/His, ORs and 95%CIs for those with ALDH-2 Glu/Glu and ADH-1B His/His was 3.42(0.57-20.38).	Histidine	58-61	aldehyde dehydrogenase 2 family member	Homo sapiens	30-36
26077029-6	2016	Amino acid analysis post the exposure of hCP to SAL revealed that aspartate, histidine, lysine, threonine and tyrosine residues were particularly sensitive.	Histidine	77-86	coproporphyrinogen oxidase	Homo sapiens	41-44
26468287-9	2015	The specificity for binding to LC3A/B is due to the interaction between Asp(1285) in FYCO1 and His(57) in LC3B.	Histidine	95-98	microtubule associated protein 1 light chain 3 beta	Homo sapiens	106-110
25573590-9	2015	Compared with subjects having ALDH-2 Lys+ with ADH-1B His/His, ORs and 95%CIs for those with ALDH-2 Glu/Glu and ADH-1B His/His was 3.42(0.57-20.38).	Histidine	58-61	aldehyde dehydrogenase 2 family member	Homo sapiens	93-99
32522573-2	2020	Brain histamine is synthesized from an essential amino acid histidine in a reaction catalysed by histidine decarboxylase (Hdc).	Histidine	60-69	histidine decarboxylase	Mus musculus	122-125
25573590-9	2015	Compared with subjects having ALDH-2 Lys+ with ADH-1B His/His, ORs and 95%CIs for those with ALDH-2 Glu/Glu and ADH-1B His/His was 3.42(0.57-20.38).	Histidine	58-61	aldehyde dehydrogenase 2 family member	Homo sapiens	30-36
26596890-6	2015	Anti-HMGB1 antibody levels were analysed in patient and control (n = 112) sera by an in-house ELISA using recombinant histidine-tagged HMGB1.	Histidine	118-127	high mobility group box 1	Homo sapiens	135-140
25573590-9	2015	Compared with subjects having ALDH-2 Lys+ with ADH-1B His/His, ORs and 95%CIs for those with ALDH-2 Glu/Glu and ADH-1B His/His was 3.42(0.57-20.38).	Histidine	58-61	aldehyde dehydrogenase 2 family member	Homo sapiens	93-99
32503840-5	2020	Here, we generated an actin variant in which the histidine target of SETD3 was substituted with methionine.	Histidine	49-58	SET domain containing 3, actin histidine methyltransferase	Homo sapiens	69-74
25573590-9	2015	Compared with subjects having ALDH-2 Lys+ with ADH-1B His/His, ORs and 95%CIs for those with ALDH-2 Glu/Glu and ADH-1B His/His was 3.42(0.57-20.38).	Histidine	58-61	aldehyde dehydrogenase 2 family member	Homo sapiens	30-36
25573590-9	2015	Compared with subjects having ALDH-2 Lys+ with ADH-1B His/His, ORs and 95%CIs for those with ALDH-2 Glu/Glu and ADH-1B His/His was 3.42(0.57-20.38).	Histidine	58-61	aldehyde dehydrogenase 2 family member	Homo sapiens	93-99
26496248-7	2015	Using this technique, we showed that amino acid modifications by this hapten was different according to the model used and that in RHE histidine residues seem to have an important role in the formation of adducts.	Histidine	135-144	factor interacting with PAPOLA and CPSF1	Homo sapiens	131-134
32503840-6	2020	As for previously characterized histone SET domain proteins, the methionine substitution substantially (76-fold) increased binding affinity for SETD3 and inhibited SETD3 activity on histidine.	Histidine	182-191	SET domain containing 3, actin histidine methyltransferase	Homo sapiens	164-169
25619683-5	2015	RESULTS: In boys, we found an inverse association between protein (animal and vegetable) intake and DBP; and a positive association between histidine and SBP.	Histidine	140-149	selenium binding protein 1	Homo sapiens	154-157
25619683-6	2015	In girls, we observed a positive association among tryptophan, histidine with SBP and methionine with DBP.	Histidine	63-72	selenium binding protein 1	Homo sapiens	78-81
32522286-14	2020	Inhibition of CSF1R and PLCG2 abolished these neuroprotective effects of rh-CSF1 after HI.	Histidine	87-89	colony stimulating factor 1 receptor	Rattus norvegicus	14-19
25711523-1	2015	The tumor-suppressor protein fragile histidine triad (Fhit) exerts its functions in the cytoplasm, although some reports suggest that it may also act in the nucleus.	Histidine	37-46	fragile histidine triad diadenosine triphosphatase	Homo sapiens	54-58
32522286-15	2020	CONCLUSIONS: Our findings demonstrated that the activation of CSF1R by rh-CSF1 attenuated neuroinflammation and improved neurological deficits after HI.	Histidine	149-151	colony stimulating factor 1 receptor	Rattus norvegicus	62-67
26494721-5	2015	The maternal alpha2 globin gene sequencing showed heterozygosity for haemoglobin M Boston (alpha58 His   Tyr).	Histidine	99-102	hemoglobin subunit alpha 2	Homo sapiens	13-26
32184263-0	2020	SNAP29 mediates the assembly of histidine-induced CTP synthase filaments in proximity to the cytokeratin network.	Histidine	32-41	synaptosome associated protein 29	Homo sapiens	0-6
26164497-1	2015	Histidine decarboxylase (HDC) catalyzes the biosynthesis of histamine from L-histidine and is expressed throughout the mammalian nervous system by histaminergic neurons.	Histidine	75-86	histidine decarboxylase	Homo sapiens	0-23
26164497-1	2015	Histidine decarboxylase (HDC) catalyzes the biosynthesis of histamine from L-histidine and is expressed throughout the mammalian nervous system by histaminergic neurons.	Histidine	75-86	histidine decarboxylase	Homo sapiens	25-28
25960268-2	2015	Here we report that replacement of the HxD-histidine with Arginine or Phenylalanine in Aurora A abolishes both the catalytic activity and auto-phosphorylation, whereas the Histidine-to-tyrosine impairs the catalytic activity without affecting its auto-phosphorylation.	Histidine	43-52	aurora kinase A	Homo sapiens	87-95
25960268-2	2015	Here we report that replacement of the HxD-histidine with Arginine or Phenylalanine in Aurora A abolishes both the catalytic activity and auto-phosphorylation, whereas the Histidine-to-tyrosine impairs the catalytic activity without affecting its auto-phosphorylation.	Histidine	172-181	aurora kinase A	Homo sapiens	87-95
25960268-3	2015	Comparisons of the crystal structures of wild-type (WT) and mutant Aurora A demonstrate that the impairment of the kinase activity is accounted for by (1) disruption of the regulatory spine in the His-to-Arg mutant, and (2) change in the geometry of backbones of the Asp-Phe-Gly (DFG) motif and the DFG-1 residue in the His-to-Tyr mutant.	Histidine	197-200	aurora kinase A	Homo sapiens	67-75
25960268-3	2015	Comparisons of the crystal structures of wild-type (WT) and mutant Aurora A demonstrate that the impairment of the kinase activity is accounted for by (1) disruption of the regulatory spine in the His-to-Arg mutant, and (2) change in the geometry of backbones of the Asp-Phe-Gly (DFG) motif and the DFG-1 residue in the His-to-Tyr mutant.	Histidine	320-323	aurora kinase A	Homo sapiens	67-75
32184263-3	2020	We have previously demonstrated that histidine (His)-mediated methylation regulates the formation of CTPS filaments to suppress enzymatic activity and preserve the CTPS protein under Gln deprivation, which promotes cancer cell growth after stress alleviation.	Histidine	37-46	CTP synthase 1	Homo sapiens	101-105
32184263-3	2020	We have previously demonstrated that histidine (His)-mediated methylation regulates the formation of CTPS filaments to suppress enzymatic activity and preserve the CTPS protein under Gln deprivation, which promotes cancer cell growth after stress alleviation.	Histidine	37-46	CTP synthase 1	Homo sapiens	164-168
25586178-9	2015	Although we identified Duox1 A-loop residues (His(1071), His(1072), and Gly(1074)) important for reducing O2 (-) release, mutations of these residues to those of Duox2 failed to convert Duox1 to an O2 (-)-releasing enzyme.	Histidine	46-49	dual oxidase 1	Homo sapiens	23-28
32184263-3	2020	We have previously demonstrated that histidine (His)-mediated methylation regulates the formation of CTPS filaments to suppress enzymatic activity and preserve the CTPS protein under Gln deprivation, which promotes cancer cell growth after stress alleviation.	Histidine	48-51	CTP synthase 1	Homo sapiens	101-105
26229101-9	2015	Reciprocal mutation of alanine 145, histidine 180, and isoleucine 191 on 14-3-3sigma isoform promotes GluN2C binding and surface expression.	Histidine	36-45	glutamate ionotropic receptor NMDA type subunit 2C	Homo sapiens	102-108
25561730-5	2015	The molecular modeling study showed that Ile(196) at transmembrane helix 2, Met(233) at ECL1, and Asn(302) at ECL2 of GLP1R have contacts with His(1) and Thr(7) of GLP-1.	Histidine	143-146	glucagon like peptide 1 receptor	Homo sapiens	118-123
32184263-3	2020	We have previously demonstrated that histidine (His)-mediated methylation regulates the formation of CTPS filaments to suppress enzymatic activity and preserve the CTPS protein under Gln deprivation, which promotes cancer cell growth after stress alleviation.	Histidine	48-51	CTP synthase 1	Homo sapiens	164-168
32384736-3	2020	Here, we established the Bacillus anthracis protein toxins" transport component PA63 as transporter for the delivery of His-tagged human NDPK-A into the cytosol of cultured cells including human MDA-MB-231 breast cancer cells.	Histidine	120-123	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	137-143
25562630-5	2015	The protective effect of carnosine or histidine was completely abolished by alpha-fluoromethylhistidine (alpha-FMH), a selective and irreversible histidine decarboxylase inhibitor, or in histidine decarboxylase deficient (HDC-KO) mice.	Histidine	38-47	histidine decarboxylase	Mus musculus	146-169
25562630-5	2015	The protective effect of carnosine or histidine was completely abolished by alpha-fluoromethylhistidine (alpha-FMH), a selective and irreversible histidine decarboxylase inhibitor, or in histidine decarboxylase deficient (HDC-KO) mice.	Histidine	38-47	histidine decarboxylase	Mus musculus	187-210
25952097-5	2015	A high-level expression of the histidine-tagged thioredoxin fusion protein was obtained after 8 h of incubation.	Histidine	31-40	thioredoxin	Bos taurus	48-59
32436451-1	2020	Hb Westmead (alpha122(H5)His>Gln) (HBA2: c.369C>G) is a common alpha-globin variant causing alpha-thalassemia (alpha-thal) in Mainland China.	Histidine	25-28	hemoglobin subunit alpha 2	Homo sapiens	35-39
25855728-4	2015	In this study, we found that the third cysteine (C21) and the last histidine (H25) in the zinc binding motif (CCCH) of hMPV M2-1 were essential for zinc binding activity, whereas the first two cysteines (C7 and C15) play only minor or redundant roles in zinc binding.	Histidine	67-76	matrix protein M2-1;matrix protein M2-2	Human metapneumovirus	124-128
25373728-6	2015	Using the described method for detecting histidine and aspartic acid phosphorylations and our prostate cancer progression cell system, the potential function of NM23-H1 in suppressing metastasis with a two-component regulation system is discussed.	Histidine	41-50	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	161-168
26137124-1	2015	The fragile histidine triad (FHIT) gene is known to be a tumor suppressor gene and the abnormal methylation of FHIT has been identified in leukemia and several solid tumors.	Histidine	12-21	fragile histidine triad diadenosine triphosphatase	Homo sapiens	29-33
32436451-1	2020	Hb Westmead (alpha122(H5)His>Gln) (HBA2: c.369C>G) is a common alpha-globin variant causing alpha-thalassemia (alpha-thal) in Mainland China.	Histidine	25-28	hemoglobin subunit alpha 2	Homo sapiens	63-75
26137124-1	2015	The fragile histidine triad (FHIT) gene is known to be a tumor suppressor gene and the abnormal methylation of FHIT has been identified in leukemia and several solid tumors.	Histidine	12-21	fragile histidine triad diadenosine triphosphatase	Homo sapiens	111-115
25531836-9	2015	Mutation of His to Gln or Leu weakens the ability of resveratrol to inhibit amyloid formation by IAPP, as do mutations of Arg-11, Phe-15, or Tyr-37 to Leu, and truncation to form the variant Ac 8-37-IAPP, which removes the first seven residues to eliminate Lys-1 and the N-terminal amino group.	Histidine	12-15	islet amyloid polypeptide	Homo sapiens	97-101
25531836-9	2015	Mutation of His to Gln or Leu weakens the ability of resveratrol to inhibit amyloid formation by IAPP, as do mutations of Arg-11, Phe-15, or Tyr-37 to Leu, and truncation to form the variant Ac 8-37-IAPP, which removes the first seven residues to eliminate Lys-1 and the N-terminal amino group.	Histidine	12-15	islet amyloid polypeptide	Homo sapiens	199-203
32188693-6	2020	Substitution of the zinc-binding residue His191 in Cav3.2 reduced the channel"s sensitivity to MTSES, and introduction of the corresponding histidine into Cav3.1 sensitized it to MTSES.	Histidine	140-149	calcium voltage-gated channel subunit alpha1 G	Homo sapiens	155-161
26001608-7	2015	Histidine (His)-tagged rGP5 and fusion protein rGP5-FljB were induced with isopropyl-beta-d-thiogalactoside, verified by SDS-PAGE and western blotting, and purified via Ni-NTA affinity columns.	Histidine	0-9	glycoprotein V (platelet)	Rattus norvegicus	23-27
26001608-7	2015	Histidine (His)-tagged rGP5 and fusion protein rGP5-FljB were induced with isopropyl-beta-d-thiogalactoside, verified by SDS-PAGE and western blotting, and purified via Ni-NTA affinity columns.	Histidine	0-3	glycoprotein V (platelet)	Rattus norvegicus	23-27
31538680-1	2020	Genetic analysis has strongly implicated human FHIT (Fragile Histidine Triad) as a tumor suppressor gene, being mutated in a large proportion of early-stage cancers.	Histidine	61-70	fragile histidine triad diadenosine triphosphatase	Homo sapiens	47-51
25975556-1	2015	OBJECTIVE: To explore the interaction between folate deficiency and aberrant expression related to fragile histidine triad (FHIT) gene in the progression of cervical cancerization.	Histidine	107-116	fragile histidine triad diadenosine triphosphatase	Homo sapiens	124-128
25659431-3	2015	In this study, we established M. tuberculosis NarL/NarS as a functional two-component system and identified His(241) and Asp(61) as conserved phosphorylation sites in NarS and NarL, respectively.	Histidine	108-111	nitrate/nitrite response transcriptional regulator NarL	Mycobacterium tuberculosis H37Rv	46-50
25620968-7	2014	Identification and characterization of impl1 and impl2 mutants revealed no viable mutants for IMPL1, while two different impl2 mutants were identified and shown to be severely compromised in growth, which can be rescued by histidine.	Histidine	223-232	myo-inositol monophosphatase like 1	Arabidopsis thaliana	39-44
25261590-0	2015	Adduct levels from benzo[a]pyrenediol epoxide: Relative formation to histidine in serum albumin and to deoxyguanosine in DNA in vitro and in vivo in mice measured by LC/MS-MS methods.	Histidine	69-78	albumin	Mus musculus	82-95
25261590-7	2015	The relative rate of formation of adducts from BPDE with His in SA and with dG in DNA was investigated.	Histidine	57-60	albumin	Mus musculus	64-66
31348608-3	2020	The lysine-arginine-ornithine binding protein (LAO) is a PBP of 238 residues that binds the basic amino acids l-arginine and l-histidine with nm and mum affinity, respectively.	Histidine	125-136	interleukin 4 induced 1	Homo sapiens	4-45
25446125-4	2015	Here, we studied the pH-dependent structural stability of the intracellular C-terminal domain of human Hv1 and showed that Zn(2+) binds to His(244) and His(266) residues.	Histidine	139-142	hydrogen voltage gated channel 1	Homo sapiens	103-106
25416551-5	2015	At acidic pH, the major contribution to the destabilization of PrP comes from the protonation of histidine 187 because its replacement by tyrosine led to more stable protein (by 4.2 kJ/mol at pH 4) with slower fibrillization.	Histidine	97-106	prion protein	Mus musculus	63-66
25446125-4	2015	Here, we studied the pH-dependent structural stability of the intracellular C-terminal domain of human Hv1 and showed that Zn(2+) binds to His(244) and His(266) residues.	Histidine	152-155	hydrogen voltage gated channel 1	Homo sapiens	103-106
31348608-3	2020	The lysine-arginine-ornithine binding protein (LAO) is a PBP of 238 residues that binds the basic amino acids l-arginine and l-histidine with nm and mum affinity, respectively.	Histidine	125-136	interleukin 4 induced 1	Homo sapiens	47-50
31315927-5	2019	Purified recombinant GST-TIMAP interacted directly with purified recombinant His-MLC2.	Histidine	77-80	myosin light chain, phosphorylatable, fast skeletal muscle	Mus musculus	81-85
25735361-1	2015	BACKGROUND: Fragile histidine triad (FHIT) gene is a tumor suppressor gene which involved in breast cancer pathogenesis.	Histidine	20-29	fragile histidine triad diadenosine triphosphatase	Homo sapiens	37-41
25583361-0	2015	Histidine(7.36(305)) in the conserved peptide receptor activation domain of the gonadotropin releasing hormone receptor couples peptide binding and receptor activation.	Histidine	0-9	gonadotropin releasing hormone receptor	Homo sapiens	80-119
25583361-3	2015	We investigated GnRH interactions with the His(7.36(305)) residue of the GnRH receptor, using functional and computational analysis of modified GnRH receptors and peptides.	Histidine	43-46	gonadotropin releasing hormone 1	Homo sapiens	16-20
25583361-3	2015	We investigated GnRH interactions with the His(7.36(305)) residue of the GnRH receptor, using functional and computational analysis of modified GnRH receptors and peptides.	Histidine	43-46	gonadotropin releasing hormone 1	Homo sapiens	73-77
25583361-3	2015	We investigated GnRH interactions with the His(7.36(305)) residue of the GnRH receptor, using functional and computational analysis of modified GnRH receptors and peptides.	Histidine	43-46	gonadotropin releasing hormone 1	Homo sapiens	73-77
25583361-4	2015	Non-polar His(7.36(305)) substitutions decreased receptor affinity for GnRH four- to forty-fold, whereas GnRH signaling potency was more decreased (~150-fold).	Histidine	10-13	gonadotropin releasing hormone 1	Homo sapiens	71-75
25583361-5	2015	Uncharged polar His(7.36(305)) substitutions decreased GnRH potency, but not affinity.	Histidine	16-19	gonadotropin releasing hormone 1	Homo sapiens	55-59
31231904-9	2019	The vertical line drawn down from the proximal His in the LAO view was a good indicator of JR1 appearance (sensitivity and specificity 84.6% and 81.6%, respectively).	Histidine	47-50	interleukin 4 induced 1	Homo sapiens	58-61
25583361-6	2015	[2-Nal(3)]-GnRH retained high affinity at receptors with non-polar His(7.36(305)) substitutions, supporting a role for His(7.36(305)) in recognizing Trp(3) of GnRH.	Histidine	67-70	gonadotropin releasing hormone 1	Homo sapiens	11-15
25583361-6	2015	[2-Nal(3)]-GnRH retained high affinity at receptors with non-polar His(7.36(305)) substitutions, supporting a role for His(7.36(305)) in recognizing Trp(3) of GnRH.	Histidine	119-122	gonadotropin releasing hormone 1	Homo sapiens	11-15
26193975-1	2015	In this study, we describe the clinical features and provide experimental analyses of Hb Flurlingen (HBA2: c.177 C &gt; G, p.His &gt; Gln) that contrasted with Hb Boghe (HBA2: c.177 C &gt; A, p.His &gt; Gln).	Histidine	125-128	hemoglobin subunit alpha 2	Homo sapiens	101-105
25658355-6	2015	Similarly, when lupin seeds were germinated for a few days, the his-tag containing 11S globulin chain was converted to a form devoid of such region, suggesting that this mechanism is a part of the natural degradatory process of the protein.	Histidine	64-67	5'-nucleotidase, cytosolic IIIA	Homo sapiens	16-21
31231904-10	2019	CONCLUSION: The vertical line drawn down from the proximal His in the LAO view can be employed as a boundary to avoid fast JR during ablation in AVNRT.	Histidine	59-62	interleukin 4 induced 1	Homo sapiens	70-73
31289320-0	2019	MIG1 as a positive regulator for the histidine biosynthesis pathway and as a global regulator in thermotolerant yeast Kluyveromyces marxianus.	Histidine	37-46	transcription factor MIG1	Saccharomyces cerevisiae S288C	0-4
25645531-8	2015	In DNase I footprinting and gel mobility shift assays, paired mutations at positions -55 and -54 did not affect Mor binding but decreased the synergistic binding of Mor with histidine tagged alpha (His-alpha), indicating that His-alpha binds to Pm in a sequence- and/or structure-specific manner.	Histidine	174-183	Mor	Escherichia phage Mu	165-168
25645531-8	2015	In DNase I footprinting and gel mobility shift assays, paired mutations at positions -55 and -54 did not affect Mor binding but decreased the synergistic binding of Mor with histidine tagged alpha (His-alpha), indicating that His-alpha binds to Pm in a sequence- and/or structure-specific manner.	Histidine	198-201	Mor	Escherichia phage Mu	165-168
25645531-8	2015	In DNase I footprinting and gel mobility shift assays, paired mutations at positions -55 and -54 did not affect Mor binding but decreased the synergistic binding of Mor with histidine tagged alpha (His-alpha), indicating that His-alpha binds to Pm in a sequence- and/or structure-specific manner.	Histidine	226-229	Mor	Escherichia phage Mu	165-168
25524476-7	2015	Through the colocalized enzymatic activity of Histidine decarboxylase in the histaminergic neurons, the resulting L-histidine may subsequently be converted into histamine, which could be responsible for the effects of carnosine on neurotransmission and physiological function.	Histidine	114-125	histidine decarboxylase	Homo sapiens	46-69
25413139-3	2014	METHODS: The GRPR antagonist JMV594 (H-D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2) was conjugated to NODA-MPAA for labeling with Al(18)F. JMV5132 was radiolabeled with (68)Ga and (18)F, and JMV4168 was labeled with (68)Ga for comparison.	Histidine	65-68	gastrin releasing peptide receptor	Mus musculus	13-17
31289320-1	2019	Kmmig1 as a disrupted mutant of MIG1 encoding a regulator for glucose repression in Kluyveromyces marxianus exhibits a histidine-auxotrophic phenotype.	Histidine	119-128	transcription factor MIG1	Saccharomyces cerevisiae S288C	32-36
25652856-1	2015	OBJECTIVE: To construct the prokaryotic expression vector of human autophagy-related protein 4 homolog B (ATG4B) labeled with His-tag, obtain the purified His-ATG4B protein, and identify its activity preliminarily.	Histidine	126-129	autophagy related 4B cysteine peptidase	Homo sapiens	67-104
31289320-4	2019	Considering the fact that His4 catalyzes four of ten steps in histidine biosynthesis, K. marxianus has evolved a novel and effective regulation mechanism via Mig1 for the control of histidine biosynthesis.	Histidine	62-71	transcription factor MIG1	Saccharomyces cerevisiae S288C	158-162
25652856-1	2015	OBJECTIVE: To construct the prokaryotic expression vector of human autophagy-related protein 4 homolog B (ATG4B) labeled with His-tag, obtain the purified His-ATG4B protein, and identify its activity preliminarily.	Histidine	126-129	autophagy related 4B cysteine peptidase	Homo sapiens	106-111
25652856-1	2015	OBJECTIVE: To construct the prokaryotic expression vector of human autophagy-related protein 4 homolog B (ATG4B) labeled with His-tag, obtain the purified His-ATG4B protein, and identify its activity preliminarily.	Histidine	155-158	autophagy related 4B cysteine peptidase	Homo sapiens	67-104
31289320-4	2019	Considering the fact that His4 catalyzes four of ten steps in histidine biosynthesis, K. marxianus has evolved a novel and effective regulation mechanism via Mig1 for the control of histidine biosynthesis.	Histidine	182-191	transcription factor MIG1	Saccharomyces cerevisiae S288C	158-162
25652856-1	2015	OBJECTIVE: To construct the prokaryotic expression vector of human autophagy-related protein 4 homolog B (ATG4B) labeled with His-tag, obtain the purified His-ATG4B protein, and identify its activity preliminarily.	Histidine	155-158	autophagy related 4B cysteine peptidase	Homo sapiens	106-111
25652856-1	2015	OBJECTIVE: To construct the prokaryotic expression vector of human autophagy-related protein 4 homolog B (ATG4B) labeled with His-tag, obtain the purified His-ATG4B protein, and identify its activity preliminarily.	Histidine	155-158	autophagy related 4B cysteine peptidase	Homo sapiens	159-164
31144503-6	2019	First, we show that the permeabilization ability of p3, but not p1, is strongly inhibited at pH 6.0 when the conserved histidines are partially charged and H17 is predominantly neutral.	Histidine	119-129	phenylalanine hydroxylase	Homo sapiens	93-95
25652856-3	2015	After verification by enzyme digestion, the correct recombinant plasmid His-ATG4B was introduced into E.coli Rossate.	Histidine	72-75	autophagy related 4B cysteine peptidase	Homo sapiens	76-81
25652856-5	2015	The function of the purified protein His-ATG4B was detected by GST pull-down assay.	Histidine	37-40	autophagy related 4B cysteine peptidase	Homo sapiens	41-46
25652856-7	2015	The results of double digestion and sequencing suggested that the His-ATG4B recombinant plasmid was successfully obtained.	Histidine	66-69	autophagy related 4B cysteine peptidase	Homo sapiens	70-75
25652856-9	2015	GST pull-down assay showed that His-ATG4B could interact with LC3B in vitro, suggesting that it has a good biological function.	Histidine	32-35	autophagy related 4B cysteine peptidase	Homo sapiens	36-41
25490830-8	2014	3) CS/pIRES2-EGFP-hBMP2-His nanoparticles were globular with an average size of 111.7 nm to 3,214.2 nm and an average zeta-potential of 4.93 mV to 16.79 mV.	Histidine	24-27	bone morphogenetic protein 2	Homo sapiens	18-23
25490830-9	2014	CONCLUSION: CS/pIRES2-EGFP-hBMP2-His nanospheres are successfully synthesized.	Histidine	33-36	bone morphogenetic protein 2	Homo sapiens	27-32
31144503-11	2019	Overall, these results provide mechanistic insights into how differences in the histidine content and amphipathicity of peptides can elicit different directionality of membrane insertion and pH-dependent permeabilization.	Histidine	80-89	phenylalanine hydroxylase	Homo sapiens	191-193
25451928-0	2015	Significantly enhanced heme retention ability of myoglobin engineered to mimic the third covalent linkage by nonaxial histidine to heme (vinyl) in synechocystis hemoglobin.	Histidine	118-127	myoglobin	Physeter catodon	49-58
30903741-7	2019	We determine the structure of YAP in complex with this mutant form of TEAD and show that the histidine residue adopts different conformations at the binding interface.	Histidine	93-102	Yes1 associated transcriptional regulator	Homo sapiens	30-33
25460508-3	2015	Using a methylation microarray, we identified promoter hypermethylation of FHIT (fragile histidine triad) in radioresistant OML1-R cells, established from hypo-fractionated irradiation of parental OML1 radiosensitive oral cancer cells.	Histidine	89-98	fragile histidine triad diadenosine triphosphatase	Homo sapiens	75-79
25056690-3	2014	Brain histamine is synthesized from L-histidine in the presence of histidine decarboxylase, which is expressed in histamine neurons.	Histidine	36-47	histidine decarboxylase	Mus musculus	67-90
25143596-1	2014	To explore dual-specificity in a small protein interface, we previously generated a "metal switch" anti-RNase A VHH antibody using a combinatorial histidine library approach.	Histidine	147-156	ribonuclease A family member 1, pancreatic	Homo sapiens	104-111
30992364-0	2019	Tau repeat regions contain conserved histidine residues that modulate microtubule-binding in response to changes in pH.	Histidine	37-46	phenylalanine hydroxylase	Homo sapiens	116-118
24986677-3	2014	Fluorescein isothiocyanate-labeled luteinizing hormone-releasing hormone (LHRH) peptides were attached to the surface of a Ni block via a histidine-tagged LHRH interaction to specifically bind to a breast cancer cell line, MCF-7.	Histidine	138-147	gonadotropin releasing hormone 1	Homo sapiens	35-72
24986677-3	2014	Fluorescein isothiocyanate-labeled luteinizing hormone-releasing hormone (LHRH) peptides were attached to the surface of a Ni block via a histidine-tagged LHRH interaction to specifically bind to a breast cancer cell line, MCF-7.	Histidine	138-147	gonadotropin releasing hormone 1	Homo sapiens	74-78
24986677-3	2014	Fluorescein isothiocyanate-labeled luteinizing hormone-releasing hormone (LHRH) peptides were attached to the surface of a Ni block via a histidine-tagged LHRH interaction to specifically bind to a breast cancer cell line, MCF-7.	Histidine	138-147	gonadotropin releasing hormone 1	Homo sapiens	155-159
25261590-9	2015	The specific and stable BPDE-adducts to His in SA are potential biomarkers of in vivo dose of BPDE, though this requires a considerable improved analytical sensitivity of the LC/MS-MS method.	Histidine	40-43	albumin	Mus musculus	47-49
25553350-2	2014	CASP8 D302H (rs1045485) (D, Aspartate; H, Histidine) and CASP8 -652 6N del (rs3834129) polymorphisms have been reported to be associated with Cancer susceptibility.	Histidine	42-51	caspase 8	Homo sapiens	0-5
30992364-4	2019	Here, we used molecular dynamics, microtubule-binding experiments, and live-cell microscopy, revealing that highly-conserved histidine residues near the C terminus of each microtubule-binding repeat are pH sensors that can modulate tau-microtubule interaction strength within the physiological intracellular pH range.	Histidine	125-134	phenylalanine hydroxylase	Homo sapiens	203-205
30992364-4	2019	Here, we used molecular dynamics, microtubule-binding experiments, and live-cell microscopy, revealing that highly-conserved histidine residues near the C terminus of each microtubule-binding repeat are pH sensors that can modulate tau-microtubule interaction strength within the physiological intracellular pH range.	Histidine	125-134	phenylalanine hydroxylase	Homo sapiens	308-310
25404067-1	2014	Using the chain-build-up method based on Empirical Conformational Energies of Peptides Program including solvation, we have computed, the low energy conformations of gonadotrpin-releasing hormone, GnRH, whose sequence is Pyro-Glu(PG)-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2.	Histidine	234-237	gonadotropin releasing hormone 1	Homo sapiens	197-201
30992364-5	2019	We observed that at low pH (<7.5), these histidines are positively charged and interact with phenylalanine residues in a hydrophobic cleft between adjacent tubulin dimers.	Histidine	41-51	phenylalanine hydroxylase	Homo sapiens	24-26
30589936-2	2019	Certain host cells express the histidine decarboxylase enzyme (HDC), which is responsible for catalysing the decarboxylation of histidine to histamine.	Histidine	31-40	histidine decarboxylase	Mus musculus	63-66
25262410-8	2014	Controlled exposure to UV light was used to produce stable linear gradients of His-tagged recombinant SDF-1alpha co-immobilized with ICAM-1 following our surface chemistry approach.	Histidine	79-82	intercellular adhesion molecule 1	Mus musculus	133-139
25019411-1	2014	Three new branched peptides, namely, H-Gly-Dap(H-Gly)-Gly-NH2 (3G), H-His-Dap(H-His)-Gly-NH2 (2HG), and H-Gly-Dap(H-Gly)-His-NH2 (2GH), where Dap stands for the 2,3-diaminopropionic acid residue, were synthesized by solid phase procedures.	Histidine	70-73	death associated protein	Homo sapiens	74-77
25019411-1	2014	Three new branched peptides, namely, H-Gly-Dap(H-Gly)-Gly-NH2 (3G), H-His-Dap(H-His)-Gly-NH2 (2HG), and H-Gly-Dap(H-Gly)-His-NH2 (2GH), where Dap stands for the 2,3-diaminopropionic acid residue, were synthesized by solid phase procedures.	Histidine	70-73	death associated protein	Homo sapiens	74-77
25019411-1	2014	Three new branched peptides, namely, H-Gly-Dap(H-Gly)-Gly-NH2 (3G), H-His-Dap(H-His)-Gly-NH2 (2HG), and H-Gly-Dap(H-Gly)-His-NH2 (2GH), where Dap stands for the 2,3-diaminopropionic acid residue, were synthesized by solid phase procedures.	Histidine	70-73	death associated protein	Homo sapiens	74-77
30826286-13	2019	Furthermore, a specific residue difference between CRFR1 subtypes (glutamate) and CRFR2beta (histidine) in this interface region may impair CRFR2beta:RAMP2 interaction by electrostatic repulsion.	Histidine	93-102	corticotropin releasing hormone receptor 1	Homo sapiens	51-56
24835186-7	2014	In a histidine-tagged catalase overexpressing cell line the HIS-1 anti-polyhistidine monoclonal antibody showed nuclear staining, whilst staining with the CAT-505 anti-catalase monoclonal antibody showed primarily cytoplasmic staining.	Histidine	5-14	viral integration site 1	Homo sapiens	60-65
25327705-3	2014	As a phospholipase D superfamily member Tdp1 utilizes two catalytic histidines each within a His-Lys-Asn motif.	Histidine	68-78	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	40-44
25327705-3	2014	As a phospholipase D superfamily member Tdp1 utilizes two catalytic histidines each within a His-Lys-Asn motif.	Histidine	93-96	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	40-44
30826412-6	2019	The results showed that the GST-VP28, His-tagged Rab7 (His-Rab7) and His-beta-actin formed a tripartite complex.	Histidine	38-41	RAB7B, member RAS oncogene family	Homo sapiens	49-53
30826412-6	2019	The results showed that the GST-VP28, His-tagged Rab7 (His-Rab7) and His-beta-actin formed a tripartite complex.	Histidine	38-41	RAB7B, member RAS oncogene family	Homo sapiens	59-63
24729090-1	2014	Our current meta-analysis is aimed to investigate the relationships between fragile histidine triad (FHIT) protein expression and prognosis in gastric cancer patients.	Histidine	84-93	fragile histidine triad diadenosine triphosphatase	Homo sapiens	101-105
30826412-6	2019	The results showed that the GST-VP28, His-tagged Rab7 (His-Rab7) and His-beta-actin formed a tripartite complex.	Histidine	55-58	RAB7B, member RAS oncogene family	Homo sapiens	49-53
30826412-6	2019	The results showed that the GST-VP28, His-tagged Rab7 (His-Rab7) and His-beta-actin formed a tripartite complex.	Histidine	55-58	RAB7B, member RAS oncogene family	Homo sapiens	59-63
25190478-6	2014	Comparisons of the sequences of the Lox1 and Lox2 genes in H70 with those in a line with normal lipoxygenase (HG) showed that the mutations in these genes affected a highly conserved group of six histidine residues necessary for enzymatic activity.	Histidine	196-205	seed linoleate 9S-lipoxygenase-2	Glycine max	45-49
31069201-3	2019	We show that the identified IKZF1 variant (p.His195Arg) alters a completely conserved histidine residue required for the folding of the third zinc-finger of IKAROS protein, leading to a loss of characteristic immunofluorescence nuclear staining pattern.	Histidine	86-95	IKAROS family zinc finger 1	Homo sapiens	28-33
25190478-8	2014	A single point mutation (T-A) in exon 8 of Lox2 changed histidine (H532, one of the iron-binding ligands essential for Lox2 activity) to glutamine.	Histidine	56-65	seed linoleate 9S-lipoxygenase-2	Glycine max	43-47
25190478-8	2014	A single point mutation (T-A) in exon 8 of Lox2 changed histidine (H532, one of the iron-binding ligands essential for Lox2 activity) to glutamine.	Histidine	56-65	seed linoleate 9S-lipoxygenase-2	Glycine max	119-123
25190478-9	2014	The mutation in the Lox3 gene in H70 was a single-point mutation in exon 6 (A-G), which changed the amino acid from histidine to arginine.	Histidine	116-125	seed linoleate 9S-lipoxygenase-3	Glycine max	20-24
25169977-1	2014	Histidine is converted to histamine by histidine decarboxylase (HDC).	Histidine	0-9	histidine decarboxylase	Mus musculus	39-62
25169977-1	2014	Histidine is converted to histamine by histidine decarboxylase (HDC).	Histidine	0-9	histidine decarboxylase	Mus musculus	64-67
24723222-4	2014	In principal, we generated Knickkopf versions with exchanged residues tryptophan(299), methionine(333), arginine(401), or histidine(437), and scored for the ability of the respective engineered protein to normalize the knickkopf mutant phenotype.	Histidine	122-131	knickkopf	Drosophila melanogaster	27-36
24723222-5	2014	Our results confirm the absolute necessity of tryptophan(299), methionine(333), and histidine(437) for Knickkopf function and stability, the latter two being predicted to be critical for heme binding.	Histidine	84-93	knickkopf	Drosophila melanogaster	103-112
24692542-9	2014	These results indicate that the side chains of His(281) and Ser(524) are in close proximity and contribute to a bonding interaction in FVIII that is retained in FVIIIa.	Histidine	47-50	coagulation factor VIII	Homo sapiens	135-140
24883121-6	2014	Dynamic planar imaging of Wistar rats with 111In-DTPA-nanobodies revealed that untagged nanobodies showed a 70% drop in kidney accumulation compared to Myc-His-tagged nanobodies at 50 min p.i..	Histidine	156-159	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	152-155
31069201-3	2019	We show that the identified IKZF1 variant (p.His195Arg) alters a completely conserved histidine residue required for the folding of the third zinc-finger of IKAROS protein, leading to a loss of characteristic immunofluorescence nuclear staining pattern.	Histidine	86-95	IKAROS family zinc finger 1	Homo sapiens	157-163
24561227-5	2014	We have complemented a CP24 knock-out mutant of Arabidopsis thaliana with the CP24 (Lhcb6) gene carrying a His-tag and with a mutated version lacking the ligand for chlorophyll 612, a specific pigment that in vitro experiments have indicated as the lowest energy site of the complex.	Histidine	107-110	light harvesting complex photosystem II subunit 6	Arabidopsis thaliana	78-82
24561227-5	2014	We have complemented a CP24 knock-out mutant of Arabidopsis thaliana with the CP24 (Lhcb6) gene carrying a His-tag and with a mutated version lacking the ligand for chlorophyll 612, a specific pigment that in vitro experiments have indicated as the lowest energy site of the complex.	Histidine	107-110	light harvesting complex photosystem II subunit 6	Arabidopsis thaliana	84-89
29989442-5	2019	DISCUSSION: This c.1056G&gt;T mutation is located in the exostosin domain of the EXT1 protein and leads to an amino acid change of Glutamine (Gln) to Histidine (His) at position 352.	Histidine	150-159	exostosin glycosyltransferase 1	Homo sapiens	81-85
24561227-7	2014	The presence of the His-tag allowed the purification of CP24-WT and of CP24-612 mutant in their native states.	Histidine	20-23	light harvesting complex photosystem II subunit 6	Arabidopsis thaliana	56-60
24561227-7	2014	The presence of the His-tag allowed the purification of CP24-WT and of CP24-612 mutant in their native states.	Histidine	20-23	light harvesting complex photosystem II subunit 6	Arabidopsis thaliana	71-75
24805197-1	2014	The Ser96Ala (S96A) mutation within the histidine rich Ca(2+) binding protein (HRC) has recently been linked to cardiac arrhythmias in idiopathic dilated cardiomyopathy patients, potentially attributable to an increase in spontaneous Ca(2+) release events.	Histidine	40-49	histidine rich calcium binding protein	Homo sapiens	79-82
24883121-8	2014	Similar findings were obtained with different 177Lu-DTPA-2Rs15d nanobody constructs in HER2pos tumor xenografted mice at 1 h p.i.. Kidney accumulation decreased 88% when comparing Myc-His-tagged to untagged 2Rs15d nanobody, and 95% with a coinfusion of Gelofusin, without affecting the tumor targeting capacity.	Histidine	184-187	myelocytomatosis oncogene	Mus musculus	180-183
24523290-0	2014	Regulation of the epithelial Ca2+ channel TRPV5 by reversible histidine phosphorylation mediated by NDPK-B and PHPT1.	Histidine	62-71	transient receptor potential cation channel subfamily V member 5	Homo sapiens	42-47
24523290-3	2014	Here we show that the histidine kinase, nucleoside diphosphate kinase B (NDPK-B), activates TRPV5 channel activity and Ca(2+) flux, and this activation requires histidine 711 in the carboxy-terminal tail of TRPV5.	Histidine	22-31	transient receptor potential cation channel subfamily V member 5	Homo sapiens	92-97
24523290-3	2014	Here we show that the histidine kinase, nucleoside diphosphate kinase B (NDPK-B), activates TRPV5 channel activity and Ca(2+) flux, and this activation requires histidine 711 in the carboxy-terminal tail of TRPV5.	Histidine	22-31	transient receptor potential cation channel subfamily V member 5	Homo sapiens	207-212
29989442-5	2019	DISCUSSION: This c.1056G&gt;T mutation is located in the exostosin domain of the EXT1 protein and leads to an amino acid change of Glutamine (Gln) to Histidine (His) at position 352.	Histidine	150-153	exostosin glycosyltransferase 1	Homo sapiens	81-85
30839985-2	2019	Here we report the design and syntheses of a novel class of histidine-containing hexapeptide derivatives (Nap-1 and ID-1) for in situ hydrogelation at the zinc ion-rich prostate tissue.	Histidine	60-69	inhibitor of DNA binding 1, HLH protein	Homo sapiens	116-120
30839985-3	2019	Thanks to the efficient co-ordination between zinc and histidine, both Nap-1 and ID-1 displayed excellent self-assembly capability with a high sensitivity to zinc ions at ~0.1 equivalency.	Histidine	55-64	inhibitor of DNA binding 1, HLH protein	Homo sapiens	81-85
25042711-7	2014	His-tag-containing recombinant human glucose-6-phosphate isomerase in combination with an anti-His-tag monoclonal antibody was instrumental to develop the method.	Histidine	0-3	glucose-6-phosphate isomerase	Homo sapiens	37-66
32216237-5	2019	Yeast two-hybrid assay showed the growth of SPAG6 and SPINK2 in the selective culture medium SD/-Leu/-Trp/-His, and the transfection of the CHO cells revealed the co-localization of SPAG6 and SPINK2 around the nuclei.	Histidine	107-110	serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)	Cricetulus griseus	54-60
30287687-7	2018	Using NMR-monitored pH titrations, we trace this drug-induced deprotonation event to His-110, EmrE"s C-terminal residue.	Histidine	85-88	single-pass membrane protein with aspartate rich tail 1	Homo sapiens	94-98
25056921-5	2014	These phenotypes are dependent on the presence of active RD20, since they are abolished in the rd20 null mutant and in lines overexpressing RD20, in which peroxygenase was inactivated by a point mutation of a catalytic histidine residue.	Histidine	219-228	Caleosin-related family protein	Arabidopsis thaliana	57-61
25056921-5	2014	These phenotypes are dependent on the presence of active RD20, since they are abolished in the rd20 null mutant and in lines overexpressing RD20, in which peroxygenase was inactivated by a point mutation of a catalytic histidine residue.	Histidine	219-228	Caleosin-related family protein	Arabidopsis thaliana	140-144
25221773-1	2014	BACKGROUND: Fragile histidine triad (FHIT) is considered as a member of the histidine triad (HIT) nucleotide-binding protein superfamily regarded as a putative tumor suppressor executing crucial role in inhibiting p53 degradation by MDM2.	Histidine	20-29	fragile histidine triad diadenosine triphosphatase	Homo sapiens	37-41
25221773-1	2014	BACKGROUND: Fragile histidine triad (FHIT) is considered as a member of the histidine triad (HIT) nucleotide-binding protein superfamily regarded as a putative tumor suppressor executing crucial role in inhibiting p53 degradation by MDM2.	Histidine	76-85	fragile histidine triad diadenosine triphosphatase	Homo sapiens	37-41
30340996-8	2018	Moreover, we could demonstrate by HPTLC analyses that recombinant Bacteroides thetaiotaomicron sialidase (BTSA-His) was able to cleave Neu5Ac and Neu5,9Ac2 from BSM and that the combination of BTSA-His with both NanS-His and NanS-p-His derivatives enhanced the release of de-O-acetylated core Neu5Ac and Neu5Gc from mammalian mucin O-glycans.	Histidine	111-114	N-acetylneuraminate synthase	Bos taurus	212-216
25010646-8	2014	Histidine-tagged TTP proteins were purified with Ni-NTA affinity beads and digested with trypsin and lysyl endopeptidase.	Histidine	0-9	ZFP36 ring finger protein	Homo sapiens	17-20
25114673-7	2014	RESULTS: The C/T polymorphism at His 1058 in exon 17 of INSR was associated with PCOS (obese and non-obese).	Histidine	33-36	insulin receptor	Homo sapiens	56-60
30340996-8	2018	Moreover, we could demonstrate by HPTLC analyses that recombinant Bacteroides thetaiotaomicron sialidase (BTSA-His) was able to cleave Neu5Ac and Neu5,9Ac2 from BSM and that the combination of BTSA-His with both NanS-His and NanS-p-His derivatives enhanced the release of de-O-acetylated core Neu5Ac and Neu5Gc from mammalian mucin O-glycans.	Histidine	111-114	N-acetylneuraminate synthase	Bos taurus	225-229
30340996-9	2018	Growth experiments with EHEC wildtype strain EDL933, its nanS and nanS/nanS-p1a-p7 mutant and exogenous BTSA-His in BSM demonstrated that the presence of BTSA-His enhanced growth of EDL933 and the nanS deletion mutant but not the nanS/nanS-p1a-p7 mutant.	Histidine	159-162	N-acetylneuraminate synthase	Bos taurus	57-61
30340996-9	2018	Growth experiments with EHEC wildtype strain EDL933, its nanS and nanS/nanS-p1a-p7 mutant and exogenous BTSA-His in BSM demonstrated that the presence of BTSA-His enhanced growth of EDL933 and the nanS deletion mutant but not the nanS/nanS-p1a-p7 mutant.	Histidine	159-162	N-acetylneuraminate synthase	Bos taurus	66-70
25842852-6	2014	The yeast co-transformed with pGBKT7/Daxx and pGADT7/E2 or pGADT7/E2 TAD can grow onto SD/-Trp-Leu-His and SD/-Trp-Leu-His-Ade plates.	Histidine	99-102	death domain associated protein	Homo sapiens	37-41
25842852-6	2014	The yeast co-transformed with pGBKT7/Daxx and pGADT7/E2 or pGADT7/E2 TAD can grow onto SD/-Trp-Leu-His and SD/-Trp-Leu-His-Ade plates.	Histidine	119-122	death domain associated protein	Homo sapiens	37-41
30340996-9	2018	Growth experiments with EHEC wildtype strain EDL933, its nanS and nanS/nanS-p1a-p7 mutant and exogenous BTSA-His in BSM demonstrated that the presence of BTSA-His enhanced growth of EDL933 and the nanS deletion mutant but not the nanS/nanS-p1a-p7 mutant.	Histidine	159-162	N-acetylneuraminate synthase	Bos taurus	66-70
30340996-9	2018	Growth experiments with EHEC wildtype strain EDL933, its nanS and nanS/nanS-p1a-p7 mutant and exogenous BTSA-His in BSM demonstrated that the presence of BTSA-His enhanced growth of EDL933 and the nanS deletion mutant but not the nanS/nanS-p1a-p7 mutant.	Histidine	159-162	N-acetylneuraminate synthase	Bos taurus	66-70
30340996-9	2018	Growth experiments with EHEC wildtype strain EDL933, its nanS and nanS/nanS-p1a-p7 mutant and exogenous BTSA-His in BSM demonstrated that the presence of BTSA-His enhanced growth of EDL933 and the nanS deletion mutant but not the nanS/nanS-p1a-p7 mutant.	Histidine	159-162	N-acetylneuraminate synthase	Bos taurus	66-70
30340996-9	2018	Growth experiments with EHEC wildtype strain EDL933, its nanS and nanS/nanS-p1a-p7 mutant and exogenous BTSA-His in BSM demonstrated that the presence of BTSA-His enhanced growth of EDL933 and the nanS deletion mutant but not the nanS/nanS-p1a-p7 mutant.	Histidine	159-162	N-acetylneuraminate synthase	Bos taurus	66-70
30268610-9	2018	Supplementation of a complete mixture of essential AA or Arg, Val, Leu, His, Phe, Met, and Ile individually led to greater mTOR phosphorylation.	Histidine	72-75	mechanistic target of rapamycin kinase	Bos taurus	123-127
24821782-2	2014	Here, we report the identification of a unique cytosolic nucleic acid cosensor in human airway epithelial cells and fibroblasts: DEAH (Asp-Glu-Ala-His) box polypeptide 29 (DHX29), a member of the DExD/H (Asp-Glu-x-Asp/His)-box helicase family.	Histidine	147-150	helicase for meiosis 1	Homo sapiens	227-235
24821782-2	2014	Here, we report the identification of a unique cytosolic nucleic acid cosensor in human airway epithelial cells and fibroblasts: DEAH (Asp-Glu-Ala-His) box polypeptide 29 (DHX29), a member of the DExD/H (Asp-Glu-x-Asp/His)-box helicase family.	Histidine	218-221	helicase for meiosis 1	Homo sapiens	227-235
30459425-3	2018	Here, we report that introduction of histidine at this position, D918H, makes TRPA1 channels sensitive to block by nanomolar concentration of Zn2+ and can be used to functionally tag subunits in concatemers.	Histidine	37-46	transient receptor potential cation channel subfamily A member 1	Homo sapiens	78-83
24627494-0	2014	A histidine-rich linker region in peptidylglycine alpha-amidating monooxygenase has the properties of a pH sensor.	Histidine	2-11	peptidylglycine alpha-amidating monooxygenase	Mus musculus	34-79
24627494-3	2014	We explored the hypothesis that a conserved His-rich cluster (His-Gly-His-His) in the linker region connecting its two catalytic domains senses pH and affects PAM trafficking by mutating these His residues to Ala (Ala-Gly-Ala-Ala; H3A).	Histidine	44-47	peptidylglycine alpha-amidating monooxygenase	Mus musculus	159-162
24627494-3	2014	We explored the hypothesis that a conserved His-rich cluster (His-Gly-His-His) in the linker region connecting its two catalytic domains senses pH and affects PAM trafficking by mutating these His residues to Ala (Ala-Gly-Ala-Ala; H3A).	Histidine	62-65	peptidylglycine alpha-amidating monooxygenase	Mus musculus	159-162
24627494-3	2014	We explored the hypothesis that a conserved His-rich cluster (His-Gly-His-His) in the linker region connecting its two catalytic domains senses pH and affects PAM trafficking by mutating these His residues to Ala (Ala-Gly-Ala-Ala; H3A).	Histidine	62-65	peptidylglycine alpha-amidating monooxygenase	Mus musculus	159-162
24627494-3	2014	We explored the hypothesis that a conserved His-rich cluster (His-Gly-His-His) in the linker region connecting its two catalytic domains senses pH and affects PAM trafficking by mutating these His residues to Ala (Ala-Gly-Ala-Ala; H3A).	Histidine	62-65	peptidylglycine alpha-amidating monooxygenase	Mus musculus	159-162
24627494-3	2014	We explored the hypothesis that a conserved His-rich cluster (His-Gly-His-His) in the linker region connecting its two catalytic domains senses pH and affects PAM trafficking by mutating these His residues to Ala (Ala-Gly-Ala-Ala; H3A).	Histidine	62-65	peptidylglycine alpha-amidating monooxygenase	Mus musculus	159-162
30346159-1	2018	Histidine decarboxylase is a pyridoxal 5"-phosphate enzyme catalyzing the conversion of histidine to histamine, a bioactive molecule exerting its role in many modulatory processes.	Histidine	88-97	histidine decarboxylase	Homo sapiens	0-23
24771692-5	2014	Nkx2-5(+/-) hearts had a prolonged atrio-His interval compared to the wild type, consistent with previous in vivo observations.	Histidine	41-44	NK2 homeobox 5	Mus musculus	0-6
30315137-5	2018	An evolutionarily conserved histidine in beta-catenin (found in the beta-TrCP DSGIHS destruction motif) is required for pH-dependent binding to beta-TrCP.	Histidine	28-37	armadillo	Drosophila melanogaster	41-53
24736394-5	2014	We further mapped the interaction regions to the 1-9 armadillo repeats of beta-catenin and the BTB domain of KCTD1, especially Position Ala-30 and His-33.	Histidine	147-150	potassium channel tetramerization domain containing 1	Homo sapiens	109-114
30015387-3	2018	We hypothesize that ITCs, as electrophiles, can interact with the catalytic triads (CYS, HIS, and ASP) of the proteasomal cysteine deubiquitinases USP14 and UCHL5, ultimately inhibiting their activities.	Histidine	89-92	ubiquitin specific peptidase 14	Homo sapiens	147-152
30054936-6	2018	The Site Finder module and molecular docking defined the benzimidazoles interactions with the most important catalytic residues of DNase I, including H-acceptor interaction with residue His 134 and His 252 and/or H-donor interaction with residue Glu 39.	Histidine	186-189	deoxyribonuclease 1	Bos taurus	131-138
24706911-4	2014	The structures reveal PhnZ to have an active site containing two Fe ions coordinated by four histidines and two aspartates that is strikingly similar to the carbon-carbon bond cleaving enzyme, myo-inositol-oxygenase.	Histidine	93-103	myo-inositol oxygenase	Homo sapiens	193-215
30054936-6	2018	The Site Finder module and molecular docking defined the benzimidazoles interactions with the most important catalytic residues of DNase I, including H-acceptor interaction with residue His 134 and His 252 and/or H-donor interaction with residue Glu 39.	Histidine	198-201	deoxyribonuclease 1	Bos taurus	131-138
30230320-3	2018	Here, we characterized the structural features of histidines in the chemokines CXCL8 and CXCL1 in the free, GAG heparin-bound, and CXCR2 receptor N-terminal domain-bound states using solution NMR spectroscopy.	Histidine	50-60	C-X-C motif chemokine receptor 2	Homo sapiens	131-136
24523290-6	2014	Thus these findings identify a novel mechanism by which TRPV5 and Ca(2+) reabsorption is regulated by the kidney and support the idea that histidine phosphorylation plays other, yet-uncovered roles in mammalian biology.	Histidine	139-148	transient receptor potential cation channel subfamily V member 5	Homo sapiens	56-61
30713635-4	2019	Surprisingly, side chains with increased steric bulk compared to the native Gly(-1) residue, including d-amino acids, were found to compensate for the essential block B histidine in His73Ala mutants in the initial N-S acyl shift of the protein splicing pathway.	Histidine	169-178	threonine aldolase 1, pseudogene	Homo sapiens	76-82
24129980-2	2014	In mammals, histamine is formed by decarboxylation of L-histidine, which is catalyzed by pyridoxal-5"-phosphate (PLP) dependent histidine decarboxylase (HDC, EC 4.1.1.22).	Histidine	54-65	histidine decarboxylase	Homo sapiens	128-151
24129980-2	2014	In mammals, histamine is formed by decarboxylation of L-histidine, which is catalyzed by pyridoxal-5"-phosphate (PLP) dependent histidine decarboxylase (HDC, EC 4.1.1.22).	Histidine	54-65	histidine decarboxylase	Homo sapiens	153-156
30046902-7	2018	Similar behavior was observed for the reaction with L-histidine with [Ru(eta6-p-cymene)(L-histidine)] species detected.	Histidine	52-63	endothelin receptor type A	Homo sapiens	73-76
24384130-1	2014	Histamine is formed by the conversion of l-histidine into histamine by histidine decarboxylase (HDC).	Histidine	41-52	histidine decarboxylase	Mus musculus	71-94
24384130-1	2014	Histamine is formed by the conversion of l-histidine into histamine by histidine decarboxylase (HDC).	Histidine	41-52	histidine decarboxylase	Mus musculus	96-99
30046902-7	2018	Similar behavior was observed for the reaction with L-histidine with [Ru(eta6-p-cymene)(L-histidine)] species detected.	Histidine	88-99	endothelin receptor type A	Homo sapiens	73-76
29884090-1	2018	Histidine decarboxylase (HDC) is the primary enzyme that catalyzes the conversion of histidine to histamine.	Histidine	85-94	histidine decarboxylase	Homo sapiens	0-23
24296465-1	2014	We present a joint theoretical and experimental study of the structure selective optical properties of cationic and anionic histidine-silver complexes with Ag and Ag3 which were prepared in the gas phase using mass spectroscopy coupled to electrospray ion source.	Histidine	124-133	anterior gradient 3, protein disulphide isomerase family member	Homo sapiens	163-166
24296465-4	2014	The presence of the smallest metallic subunit Ag3 increases the intensity of low energy transitions of histidine illustrating a metal cluster-induced enhancement of absorption of biomolecules in hybrid systems.	Histidine	103-112	anterior gradient 3, protein disulphide isomerase family member	Homo sapiens	46-49
24282278-8	2014	Moreover, His-MDA-7, after binding to its cognate receptors (IL-20R1/IL-20R2 or IL-22R/IL-20R2), induces intracellular signaling by phosphorylation of p38 MAPK, leading to transcription of a family of growth arrest and DNA damage inducible (GADD) genes, culminating in apoptosis.	Histidine	10-13	interleukin 20 receptor subunit beta	Homo sapiens	69-76
29884090-1	2018	Histidine decarboxylase (HDC) is the primary enzyme that catalyzes the conversion of histidine to histamine.	Histidine	85-94	histidine decarboxylase	Homo sapiens	25-28
24282278-8	2014	Moreover, His-MDA-7, after binding to its cognate receptors (IL-20R1/IL-20R2 or IL-22R/IL-20R2), induces intracellular signaling by phosphorylation of p38 MAPK, leading to transcription of a family of growth arrest and DNA damage inducible (GADD) genes, culminating in apoptosis.	Histidine	10-13	interleukin 22 receptor subunit alpha 1	Homo sapiens	80-86
24282278-8	2014	Moreover, His-MDA-7, after binding to its cognate receptors (IL-20R1/IL-20R2 or IL-22R/IL-20R2), induces intracellular signaling by phosphorylation of p38 MAPK, leading to transcription of a family of growth arrest and DNA damage inducible (GADD) genes, culminating in apoptosis.	Histidine	10-13	interleukin 20 receptor subunit beta	Homo sapiens	87-94
30109310-3	2018	Herein, MMP-2-responsive nanoprobes were prepared by immobilizing fluorescent fusion proteins on nickel ferrite nanoparticles via the His-tag nickel chelation mechanism.	Histidine	134-137	matrix metallopeptidase 2	Homo sapiens	8-13
24935385-3	2014	Therefore, the aim of this study was to evaluate the association between gene hypermethylation and expression of fragile histidine triad (FHIT), glutathione S-transferase P1 (GSTP1) and p16 genes and various clinicopathologic characteristics in primary non-small cell lung carcinomas (NSCLC).	Histidine	121-130	fragile histidine triad diadenosine triphosphatase	Homo sapiens	138-142
29991810-1	2018	The peptide/histidine transporter SLC15A3 is responsible for transporting histidine, certain dipeptide and peptidomimetics from inside the lysosome to cytosol.	Histidine	12-21	solute carrier family 15, member 3	Mus musculus	34-41
24984545-1	2014	PURPOSE: To explore the significance of combined detection of p53 genes and fragile histidine triad (FHIT) genes in cervical carcinoma.	Histidine	84-93	fragile histidine triad diadenosine triphosphatase	Homo sapiens	101-105
29953543-4	2018	Unique to KCa3.1, activation also requires phosphorylation of a single histidine residue, His358, in the cytoplasmic region, which relieves copper-mediated inhibition of the channel.	Histidine	71-80	potassium calcium-activated channel subfamily N member 4	Homo sapiens	10-16
29953543-8	2018	These results suggest that His358, the inhibitory histidine in KCa3.1, might coordinate a copper ion through a similar binding mode.	Histidine	50-59	potassium calcium-activated channel subfamily N member 4	Homo sapiens	63-69
24140098-6	2014	Wild-type and mutant CYP17A1 cDNAs were inserted into the pcDNA3.1/V5-His-P450c17 vector, and transiently expressed in COS-7 cells.	Histidine	70-73	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	74-81
29973935-2	2018	Histamine is a monoamine synthesized from the amino acid histidine through a reaction catalyzed by the enzyme histidine decarboxylase (HDC), which removes carboxyl group from histidine.	Histidine	57-66	histidine decarboxylase	Homo sapiens	110-133
23666425-8	2013	This NO acts on the RGSZ2 zinc finger, providing the zinc ions that are required for PKC/Raf-1 cysteine-rich domains to simultaneously bind to the histidines present in the HINT1 homodimer.	Histidine	147-157	regulator of G protein signaling 17	Homo sapiens	20-25
23666425-8	2013	This NO acts on the RGSZ2 zinc finger, providing the zinc ions that are required for PKC/Raf-1 cysteine-rich domains to simultaneously bind to the histidines present in the HINT1 homodimer.	Histidine	147-157	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	89-94
29973935-2	2018	Histamine is a monoamine synthesized from the amino acid histidine through a reaction catalyzed by the enzyme histidine decarboxylase (HDC), which removes carboxyl group from histidine.	Histidine	57-66	histidine decarboxylase	Homo sapiens	135-138
24056255-4	2013	The gene encoding the ESAT-6 of M. tuberculosis was inserted into a bacterial expression vector pET23a (+) resulting in a 6 x His-esat-6 fusion gene construction with histidine tag at its C-terminus.	Histidine	126-129	ESAT-6 protein EsxA	Mycobacterium tuberculosis H37Rv	22-28
29281262-11	2018	Taken together, these establish unambiguously a four-His coordination of the metal ion in the model systems, supporting the presence of our postulated binding site in the NGF/TrkA complex.	Histidine	53-56	neurotrophic receptor tyrosine kinase 1	Homo sapiens	175-179
24056255-4	2013	The gene encoding the ESAT-6 of M. tuberculosis was inserted into a bacterial expression vector pET23a (+) resulting in a 6 x His-esat-6 fusion gene construction with histidine tag at its C-terminus.	Histidine	167-176	ESAT-6 protein EsxA	Mycobacterium tuberculosis H37Rv	22-28
29449016-6	2018	Pulse radiolysis experiments, however, clearly revealed an axial ligand exchange from Cys to His immediately after the reduction of the heme iron to form a 5-coordinate His-ligated heme in heme-bound IRP2, whereas the 5-coordinate His-ligated heme was not observed after the reduction of heme-bound IRP1.	Histidine	93-96	aconitase 1	Homo sapiens	299-303
24121506-5	2013	Within L1C domains, five amino acid residues (Leu-135, Gly-188, Arg-244, and vicinal His-318 and Lys-319) were identified as IRR-specific by species conservation analysis of the IR family.	Histidine	85-88	insulin receptor	Homo sapiens	125-127
29449016-6	2018	Pulse radiolysis experiments, however, clearly revealed an axial ligand exchange from Cys to His immediately after the reduction of the heme iron to form a 5-coordinate His-ligated heme in heme-bound IRP2, whereas the 5-coordinate His-ligated heme was not observed after the reduction of heme-bound IRP1.	Histidine	169-172	aconitase 1	Homo sapiens	299-303
29449016-6	2018	Pulse radiolysis experiments, however, clearly revealed an axial ligand exchange from Cys to His immediately after the reduction of the heme iron to form a 5-coordinate His-ligated heme in heme-bound IRP2, whereas the 5-coordinate His-ligated heme was not observed after the reduction of heme-bound IRP1.	Histidine	169-172	aconitase 1	Homo sapiens	299-303
29449016-7	2018	Considering that the oxidative modification is only observed in heme-bound IRP2, but not IRP1, probably owing to the structural flexibility of IRP2, we propose that the transient 5-coordinate His-ligated heme is a prerequisite for oxidative modification of heme-bound IRP2, which functionally differentiates heme binding of IRP2 from that of IRP1.	Histidine	192-195	aconitase 1	Homo sapiens	342-346
23968392-4	2013	Conversely, the NT His-tag did result in a differential effect on protein kinase activity, further potentiating the elevated protein kinase activity of both the helical domain and catalytic domain oncogenic mutants with relation to p110 phosphorylation.	Histidine	19-22	endogenous retrovirus group K member 15	Homo sapiens	232-236
29657009-6	2018	Plasminogen binding assay showed that His-Tseno could bind to human plasminogen and generate plasmin activated by a tissue-type plasminogen activator (t-PA).	Histidine	38-41	plasminogen	Homo sapiens	68-75
29398086-7	2018	Amidase and glucosaminidase were expressed as N-terminal histidine tagged proteins from Escherichia coli, purified and refolded.	Histidine	57-66	AT695_RS13185	Staphylococcus aureus	0-7
23995934-10	2013	The two major clades within the MAR4 lineage displayed distinct patterns in the structural classes and the number and amount of HIs produced, suggesting a relationship between taxonomy and secondary metabolite production.	Histidine	128-131	retrotransposon Gag like 4	Homo sapiens	32-36
29176272-8	2018	This inverse correlation was more evident among the ADH1B His/His + ALDH2 Glu/Lys or Lys/Lys groups (-3.24 mg/dL, 95% CI, -5.03 to -1.45).	Histidine	58-61	aldehyde dehydrogenase 2 family member	Homo sapiens	68-73
24568043-2	2013	STUDY DESIGN: We ex-amined the frequency of the His 1058 C/T single nucleotide polymorphism (SNP) found in exon 17 of the INSR gene in 61 Japanese PCOS patients and 99 Japanese healthy controls.	Histidine	48-51	insulin receptor	Homo sapiens	122-126
29611000-3	2018	The helical alignment was carried out with conservation of the complete Jalpha helix of YtvA, as well as of the phosphorylatable histidine residue of the Sln1 kinase, with conservation of the hepta-helical motive of coiled-coil structures, recognizable in the helices of the two separate, constituent, proteins.	Histidine	129-138	histidine kinase	Saccharomyces cerevisiae S288C	154-158
23969757-2	2013	The fragile histidine triad (FHIT) gene is a putative tumor suppressor gene in breast and other types of cancer, and loss of Fhit expression has been observed in breast cancer.	Histidine	12-21	fragile histidine triad diadenosine triphosphatase	Homo sapiens	29-33
23969757-2	2013	The fragile histidine triad (FHIT) gene is a putative tumor suppressor gene in breast and other types of cancer, and loss of Fhit expression has been observed in breast cancer.	Histidine	12-21	fragile histidine triad diadenosine triphosphatase	Homo sapiens	125-129
29397068-5	2018	His-7, Glu-9 and Asp-15 of GLP-1 act together to destabilise transmembrane helix 6 and extracellular loop 3 in order to generate an active conformation of GLP-1R.	Histidine	0-3	glucagon like peptide 1 receptor	Homo sapiens	155-161
29164305-0	2018	Nuclear transport of the human aryl hydrocarbon receptor and subsequent gene induction relies on its residue histidine 291.	Histidine	109-118	aryl hydrocarbon receptor	Homo sapiens	31-56
23994011-4	2013	Nab2p TZF34 exhibits a distinctive two-fold symmetry of the zinc centers with mutual recognition of histidine ligands.	Histidine	100-109	NGFI-A binding protein 2	Homo sapiens	0-5
21962529-6	2013	Simultaneously, the allelic deletion status of fragile histidine triad (FHIT) gene was studied by FISH in cRCC and major epithelial carcinoma (MEC) tumors.	Histidine	55-64	fragile histidine triad diadenosine triphosphatase	Homo sapiens	72-76
29164305-4	2018	To better illuminate the ligand-mediated responses of the human AHR, we applied site-directed mutagenesis and identified histidine 291 as key residue for AHR functionality, essential for both nuclear import and target gene induction.	Histidine	121-130	aryl hydrocarbon receptor	Homo sapiens	64-67
29164305-4	2018	To better illuminate the ligand-mediated responses of the human AHR, we applied site-directed mutagenesis and identified histidine 291 as key residue for AHR functionality, essential for both nuclear import and target gene induction.	Histidine	121-130	aryl hydrocarbon receptor	Homo sapiens	154-157
29164305-6	2018	Combining these observations with our structural investigations using a homology model of the AHR-PAS B domain, we suggest a dual role of histidine 291: (1) a major role for shaping the ligand binding site including direct interactions with ligands and, (2) an essential role for the conformational dynamics of a PAS B loop, which most likely influences the association of the AHR with the AHR nuclear translocator through interference with their protein-protein interface.	Histidine	138-147	aryl hydrocarbon receptor	Homo sapiens	94-97
29164305-6	2018	Combining these observations with our structural investigations using a homology model of the AHR-PAS B domain, we suggest a dual role of histidine 291: (1) a major role for shaping the ligand binding site including direct interactions with ligands and, (2) an essential role for the conformational dynamics of a PAS B loop, which most likely influences the association of the AHR with the AHR nuclear translocator through interference with their protein-protein interface.	Histidine	138-147	aryl hydrocarbon receptor	Homo sapiens	377-380
29164305-6	2018	Combining these observations with our structural investigations using a homology model of the AHR-PAS B domain, we suggest a dual role of histidine 291: (1) a major role for shaping the ligand binding site including direct interactions with ligands and, (2) an essential role for the conformational dynamics of a PAS B loop, which most likely influences the association of the AHR with the AHR nuclear translocator through interference with their protein-protein interface.	Histidine	138-147	aryl hydrocarbon receptor	Homo sapiens	377-380
23709347-1	2013	The purpose of this study was to investigate the diagnostic value of the deletion of fragile histidine triad (FHIT) and p16INK4a (p16) mRNA in biopsies obtained by bronchoscopy.	Histidine	93-102	fragile histidine triad diadenosine triphosphatase	Homo sapiens	110-114
29434897-2	2018	Fragile histidine triad (FHIT) is a tumor suppressor gene that is frequently silenced in cervical cancer (CC) and preneoplastic lesions.	Histidine	8-17	fragile histidine triad diadenosine triphosphatase	Homo sapiens	25-29
23989155-3	2013	In this study, the human TRAF4 TRAF domain, corresponding to amino acids 290-470, was overexpressed in Escherichia coli using engineered C-terminal His tags.	Histidine	148-151	TNF receptor associated factor 4	Homo sapiens	25-30
29386103-0	2018	The C-Domain of the NAC Transcription Factor ANAC019 Is Necessary for pH-Tuned DNA Binding through a Histidine Switch in the N-Domain.	Histidine	101-110	NAC domain containing protein 19	Arabidopsis thaliana	45-52
23224405-6	2013	The granulysin yield reaches at least 100 mg/l in fermentation, and over 95 % purity was achieved with common His-select affinity and ion exchange chromatography.	Histidine	110-113	granulysin	Homo sapiens	4-14
29386103-3	2018	We studied ANAC019, a member of the NAC TF family of proteins in Arabidopsis, and found a well-conserved histidine switch located in its DBD, which regulates both homodimerization and transcriptional control of the TF through H135 protonation.	Histidine	105-114	NAC domain containing protein 19	Arabidopsis thaliana	11-18
29203646-1	2018	The Asp-His-His and Asp-His-His-associated (DHH/DHHA1) domain-containing phosphodiesterases (PDEs) that catalyze degradation of cyclic di-adenosine monophosphate (c-di-AMP) could be subdivided into two subfamilies based on the final product [5"-phosphadenylyl-adenosine (5"-pApA) or AMP].	Histidine	8-11	pappalysin 1	Homo sapiens	274-278
29203646-1	2018	The Asp-His-His and Asp-His-His-associated (DHH/DHHA1) domain-containing phosphodiesterases (PDEs) that catalyze degradation of cyclic di-adenosine monophosphate (c-di-AMP) could be subdivided into two subfamilies based on the final product [5"-phosphadenylyl-adenosine (5"-pApA) or AMP].	Histidine	12-15	pappalysin 1	Homo sapiens	274-278
24200155-1	2013	Histamine is synthesized as a low-molecular-weight amine from L-histidine by histidine decarboxylase (HDC).	Histidine	62-73	histidine decarboxylase	Mus musculus	77-100
29057978-8	2017	Due to the uncommonly high histidine content, we suggest that Emp represents a novel type of histidine-rich protein sharing structural similarities to leucine-rich repeats proteins as predicted by the I-TASSER algorithm.	Histidine	27-36	macrophage erythroblast attacher, E3 ubiquitin ligase	Homo sapiens	62-65
24200155-1	2013	Histamine is synthesized as a low-molecular-weight amine from L-histidine by histidine decarboxylase (HDC).	Histidine	62-73	histidine decarboxylase	Mus musculus	102-105
23905516-2	2013	On the other hand, it has also been suggested that recruitment of a histidine to replace the native cysteine thiolate ligand might underlie the P450   P420 transition.	Histidine	68-77	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	144-148
28523428-2	2017	Examination of the DNA-binding domain of Glis3 reveals that this domain contains a repeated cysteine 2/histidine 2 (Cys2/His2) zinc-finger motif in the central region where the recognized DNA sequence binds.	Histidine	103-112	GLIS family zinc finger 3	Mus musculus	41-46
23927287-0	2013	Acidic pH retards the fibrillization of human Islet Amyloid Polypeptide due to electrostatic repulsion of histidines.	Histidine	106-116	islet amyloid polypeptide	Homo sapiens	46-71
28808056-6	2017	A Dual-Luciferase assay demonstrated that removing the NTR domain and replacing the CRD groove residues His-116 and His-118 with aromatic residues may significantly enhance antagonistic function of Sizzled in inhibiting Wnt3A signaling.	Histidine	104-107	Wnt family member 3A S homeolog	Xenopus laevis	220-225
23720381-4	2013	The method is applied to histidine where it is able to predict atomic multipole moments (up to hexadecapole) for unseen configurations, after training on 600 geometries distorted using normal modes of each of its 24 local energy minima at B3LYP/apc-1 level.	Histidine	25-34	solute carrier family 25 member 24	Homo sapiens	245-250
28808056-6	2017	A Dual-Luciferase assay demonstrated that removing the NTR domain and replacing the CRD groove residues His-116 and His-118 with aromatic residues may significantly enhance antagonistic function of Sizzled in inhibiting Wnt3A signaling.	Histidine	116-119	Wnt family member 3A S homeolog	Xenopus laevis	220-225
28692245-5	2017	It was previously found by in vitro and simulation studies that Zn2+ ion binds to two or four His residues in the turn domain of fibrillary amylin.	Histidine	94-97	islet amyloid polypeptide	Homo sapiens	140-146
23908043-3	2013	In this study, the short form of the human TRAF4 TRAF domain, corresponding to amino acids 290-462, was overexpressed in Escherichia coli using engineered C-terminal His tags.	Histidine	166-169	TNF receptor associated factor 4	Homo sapiens	43-48
23773890-7	2013	The inhibition profile suggested that L-type amino acid transporter (LAT1/SLC7A5) is responsible for the influx transport of l-histidine across the inner BRB.	Histidine	125-136	solute carrier family 7 member 5	Rattus norvegicus	74-80
28724762-4	2017	P73 lies immediately adjacent to a putative zinc binding site (M. Li et al., J Virol 87:12166-12175, 2013, https://doi.org/10.1128/JVI.01965-13) that is formed by three icosahedrally related His residues in the N termini of the C subunit at the quasi-6-fold axes.	Histidine	191-194	tumor protein p73	Homo sapiens	0-3
28874603-2	2017	We found that increased pHi enabled the tumorigenic behaviors caused by somatic arginine-to-histidine mutations, which are frequent in cancer and confer pH sensing not seen with wild-type proteins.	Histidine	92-101	glucose-6-phosphate isomerase	Homo sapiens	24-27
23585398-3	2013	Our laboratory previously demonstrated that protein domains located within precursor proteins, propeptides, encode histidine-driven pH sensors to regulate organelle-specific activation of the eukaryotic proteases furin and proprotein convertase-1/3.	Histidine	115-124	furin, paired basic amino acid cleaving enzyme	Homo sapiens	213-218
28526614-7	2017	Furthermore, over-expression of the fused histidine-tagged ALDH3A1 confers host E. coli cells with enhanced resistance to thermal shock, while ALDH3A1 over-expression in the human corneal cell line HCE-2 was sufficient for protecting them from the cytotoxic effects of both hydrogen peroxide and tert-butyl hydroperoxide.	Histidine	42-51	aldehyde dehydrogenase family 3, subfamily A1	Mus musculus	59-66
28526614-7	2017	Furthermore, over-expression of the fused histidine-tagged ALDH3A1 confers host E. coli cells with enhanced resistance to thermal shock, while ALDH3A1 over-expression in the human corneal cell line HCE-2 was sufficient for protecting them from the cytotoxic effects of both hydrogen peroxide and tert-butyl hydroperoxide.	Histidine	42-51	aldehyde dehydrogenase 3 family member A1	Homo sapiens	143-150
28274434-0	2017	Effect of 4-hydroxy-2-nonenal on myoglobin-mediated lipid oxidation when varying histidine content and hemin affinity.	Histidine	81-90	myoglobin	Physeter catodon	33-42
23754285-10	2013	Interestingly, the proteolytic activity of mature ADAMDEC1 can be significantly enhanced when a canonical ADAM active site with three zinc-coordinating histidine residues is introduced.	Histidine	152-161	ADAM like decysin 1	Homo sapiens	50-58
23474485-4	2013	Intravenous and intracerebroventricular (ICV) administration of histidine-activated hepatic STAT3 reduced G6Pase protein and mRNA levels and augmented HGP suppression by insulin.	Histidine	64-73	glucose-6-phosphatase, catalytic	Mus musculus	106-112
28636680-3	2017	A conformer-selective NH stretch infrared study provided evidence for the formation in vacuo of two types of short-range H-bonded motifs, labelled epsilon-6delta and delta-delta7/piH, bridging the His side chain (in its gauche+ rotamer) to the neighbouring NH(i) and CO(i) sites of the backbone; each side chain-backbone motif was found to be specific of the tautomer (epsilon or delta) adopted by the His side chain in its neutral form.	Histidine	197-200	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	179-182
23560482-6	2013	Substantial production of NH2Cl from l-arginine and l-histidine was observed at Cl/P = 1.0 and 2.0 when post-chlorination was applied to UV254-irradiated samples.	Histidine	52-63	cleavage factor polyribonucleotide kinase subunit 1	Homo sapiens	80-88
23671581-4	2013	Here, we document, for the first time, that the aminocoumarin antibiotic, novobiocin, directly blocks the protein-protein interaction between the HIF1alpha C-terminal activation domain (CTAD) and the cysteine-histidine rich (CH1) region of p300/CBP.	Histidine	209-218	E1A binding protein p300	Homo sapiens	240-244
23619718-10	2013	Three MUC19 SNPs were nominally significantly associated with CD (rs11564245, Asp His: P = 0.02; rs4768261, Ser Phe: P = 0.0008; and rs2933353, Glu Ala: P = 0.01).	Histidine	82-85	mucin 19, oligomeric	Homo sapiens	6-11
23370273-0	2013	Beta conformation of polyglutamine track revealed by a crystal structure of Huntingtin N-terminal region with insertion of three histidine residues.	Histidine	129-138	huntingtin	Homo sapiens	76-86
23592920-17	2013	Sequencing of the 12 coding exons and splice sites of CRB1 disclosed a homozygous missense mutation in exon 7 at nucleotide c. 2291G&gt;A, resulting in an arginine to histidine substitution (p.R764H).	Histidine	167-176	crumbs cell polarity complex component 1	Homo sapiens	54-58
23467037-0	2013	His-Trp cation-pi interaction and its structural role in an alpha-helical dimer of HIV-1 Vpr protein.	Histidine	0-3	Vpr	Human immunodeficiency virus 1	89-92
23165241-6	2013	Comparative bioinformatic analysis of L. lactis, E. coli and Staphylococcus aureus Lgt revealed that the conserved and catalytically important His-103 residue in E. coli Lgt, was altered to Tyr in L. lactis.	Histidine	143-146	lgt	Lactococcus lactis	83-86
23165241-6	2013	Comparative bioinformatic analysis of L. lactis, E. coli and Staphylococcus aureus Lgt revealed that the conserved and catalytically important His-103 residue in E. coli Lgt, was altered to Tyr in L. lactis.	Histidine	143-146	lgt	Lactococcus lactis	170-173
23381689-2	2013	Based in enzyme kinetics experiments and (1)H NMR spectroscopic analysis we proposed that urea, at low concentrations, directly interacts with the protonated histidines of the active center of RNase A, following a simple model of competitive inhibition.	Histidine	158-168	ribonuclease A family member 1, pancreatic	Homo sapiens	193-200
23249748-3	2013	We previously demonstrated that yeast strains depleted of tRNA(His) guanylyltransferase accumulate uncharged tRNA(His) lacking the G(-1) residue and subsequently accumulate additional 5-methylcytidine (m(5)C) at residues C(48) and C(50) of tRNA(His), due to the activity of the m(5)C-methyltransferase Trm4.	Histidine	63-66	tRNA (cytosine-C5-)-methyltransferase	Saccharomyces cerevisiae S288C	302-306
23102829-1	2013	The fragile histidine triad protein, Fhit, has a number of reported tumor suppressive functions which include signaling of apoptosis in cancer cells in vitro and in vivo, modulation of the DNA damage response, down-regulation of target oncogene expression, suppression of tumor growth in vivo, and suppression of cancer cell invasion and metastasis.	Histidine	12-21	fragile histidine triad diadenosine triphosphatase	Homo sapiens	37-41
24054151-1	2013	VMAT2 is the vesicular monoamine transporter that allows DA, NE, Epi, His, and 5-HT uptake into neurons and endocrine cells.	Histidine	70-73	solute carrier family 18 member A2	Homo sapiens	0-5
23736021-2	2013	The aim of this study was to evaluate the diagnostic value of the fragile histidine triad (FHIT) and p16 mRNA loss and the K-ras gene mutation in distinguishing malignant from benign pleural effusion.	Histidine	74-83	fragile histidine triad diadenosine triphosphatase	Homo sapiens	91-95
23082897-0	2012	Detection and identification of heme c-modified peptides by histidine affinity chromatography, high-performance liquid chromatography-mass spectrometry, and database searching.	Histidine	60-69	HEME	Bos taurus	32-36
23082897-3	2012	Using a recently reported histidine affinity chromatography (HAC) procedure, we enriched heme c tryptic peptides from purified bovine heart cytochrome c, two bacterial decaheme cytochromes, and subjected these samples to LC-MS/MS analysis.	Histidine	26-35	HEME	Bos taurus	89-93
22847929-7	2012	RESULTS: We detected a total of five variants in the ZIC2 gene: a common histidine tract expansion c.716_718dup (p.His239dup), a rare c.1377_1391del_homozygous (p.Ala466_470del, or Ala 15 to 10 contraction), a novel intronic c.1239+18G&gt;A variant, a novel frameshift c.1215dupC (p.Ser406Glnfs*11), and a c.1401_1406dup (p.Ala469_470dup, or alanine tract expansion to 17 residues).	Histidine	73-82	Zic family member 2	Homo sapiens	53-57
22940786-1	2012	Histamine (HA), a mediator of inflammation, type I allergic responses and             neurotransmission, is synthesized from L-histidine, the reaction of which is catalyzed             by histidine decarboxylase (HDC).	Histidine	125-136	histidine decarboxylase	Homo sapiens	188-211
22940786-1	2012	Histamine (HA), a mediator of inflammation, type I allergic responses and             neurotransmission, is synthesized from L-histidine, the reaction of which is catalyzed             by histidine decarboxylase (HDC).	Histidine	125-136	histidine decarboxylase	Homo sapiens	213-216
22869372-11	2012	AMPK does not appear to phosphorylate NDPK-A directly but rather promotes an NDPK-A autophosphorylation event that involves His-118 and Ser-120.	Histidine	124-127	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	0-4
22869372-11	2012	AMPK does not appear to phosphorylate NDPK-A directly but rather promotes an NDPK-A autophosphorylation event that involves His-118 and Ser-120.	Histidine	124-127	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	77-83
22575527-6	2012	A histidine tagged CD14 (CD14/His) was also expressed as control.	Histidine	2-11	CD14 molecule	Homo sapiens	19-23
22575527-6	2012	A histidine tagged CD14 (CD14/His) was also expressed as control.	Histidine	2-11	CD14 molecule	Homo sapiens	25-29
22575527-6	2012	A histidine tagged CD14 (CD14/His) was also expressed as control.	Histidine	30-33	CD14 molecule	Homo sapiens	19-23
22767596-6	2012	The S354G mutation at the active site enlarged the size of the hHDC substrate-binding pocket and resulted in a decreased affinity for histidine, but an acquired ability to bind and act on L-DOPA as a substrate.	Histidine	134-143	histidine decarboxylase	Homo sapiens	63-67
22932087-2	2012	Our study aimed to investigate the differential expression of Ki-67, galectin-3, fragile histidine triad (FHIT) gene, and parafibromin in PC, parathyroid adenoma (PA), parathyroid hyperplasia (PH), and normal parathyroid (NP) tissues; then to assess these expression values for use in differential diagnosis of malignant and benign parathyroid tumors.	Histidine	89-98	fragile histidine triad diadenosine triphosphatase	Homo sapiens	106-110
22665377-4	2012	An approximately 100-kDa protein was recovered by using recombinant His-tagged SSL3-conjugated Sepharose from the lysate of porcine spleen, and the protein was identified as porcine TLR2 by peptide mass fingerprinting analysis.	Histidine	68-71	toll-like receptor 2	Mus musculus	182-186
22240897-3	2012	Here, we repot that golgi-specific Asp-His-His-Cys (DHHC) zinc finger protein (GODZ) regulates TRAIL/DR4-mediated apoptosis.	Histidine	39-42	TNF receptor superfamily member 10a	Homo sapiens	101-104
21679157-1	2012	Accumulating evidence has demonstrated that FHIT (fragile histidine triad) is a bona fide tumour suppressor gene in a large fraction of human tumours, including hepatocellular cancer.	Histidine	58-67	fragile histidine triad diadenosine triphosphatase	Homo sapiens	44-48
22577234-12	2012	CONCLUSION: Imaging with the radiocopper-histidine complex successfully identified Atp7b-dependent biliary copper excretion.	Histidine	41-50	ATPase copper transporting beta	Rattus norvegicus	83-88
22212708-7	2012	The ATP6V1F gene was overexpressed in Escherichia coli indicating that ATP6V1F fusion with the N-terminally His-tagged form gave rise to the accumulation of an expected 17 kDa polypeptide, which was according with the predicted protein and also could be used to purify the protein and study its function.	Histidine	108-111	V-type proton ATPase subunit F	Ailuropoda melanoleuca	4-11
22222967-8	2012	In addition, cysteine at 665 in the N terminus and histidine at 983 in the C terminus were important for hTRPA1 activation by primary alcohols.	Histidine	51-60	transient receptor potential cation channel subfamily A member 1	Homo sapiens	105-111
22243664-6	2012	His-tag site-specific PEGylation was achieved with a domain antibody (dAb) that had a 6-histidine His-tag on the C-terminus (dAb-His(6)) and interferon alpha-2a (IFN) that had an 8-histidine His-tag on the N-terminus (His(8)-IFN).	Histidine	0-3	interferon alpha 2	Homo sapiens	141-160
22218462-7	2012	We have developed two high-throughput screens suitable assays using both homogenous time-resolved fluorescence energy transfer and AlphaScreen technologies to detect the binding of a C-terminally His-tagged MBNL1 and a biotinylated (CUG)(12) RNA.	Histidine	196-199	muscleblind like splicing regulator 1	Homo sapiens	207-212
22020791-6	2012	Moreover, in order to improve production of functional             LPI/PEP-19, we modified the protocol normally adopted for preparing histidine             tagged-proteins from bacteria, by adding an additional purification step.	Histidine	135-144	Purkinje cell protein 4	Rattus norvegicus	71-77
22130545-7	2012	Mutations within a conserved cysteine/histidine-rich, putative E3 ligase domain impaired the ability of RTA to induce RelA ubiquitination and degradation.	Histidine	38-47	RELA proto-oncogene, NF-kB subunit	Homo sapiens	118-122
22848751-8	2012	Substrate-docking to zebrafish wild-type protein, and characterization of the ADPRibase-Mn H97A mutant pointed to a role of His-97 in catalysis by orientation, and to a bidentate water bridging the dinuclear metal center as the potential nucleophile.	Histidine	124-127	ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent	Danio rerio	78-90
22479576-4	2012	Muscleblind-proteins bind to RNAs via N-terminal zinc fingers of the Cys(3)-His type.	Histidine	76-79	muscleblind	Drosophila melanogaster	0-11
21925214-6	2011	Immunoprecipitation analyses showed that NAD interacts with the Cystein/Histidine region (CH) 1 and CH3 domains of p300.	Histidine	72-81	E1A binding protein p300	Homo sapiens	115-119
22085272-1	2011	The candidate tumor suppressor fragile histidine traid (FHIT) is frequently inactivated in small cell lung cancer (SCLC).	Histidine	39-48	fragile histidine triad diadenosine triphosphatase	Homo sapiens	56-60
22131323-3	2011	Divalent cations Zn(2+), Cu(2+) and Ni(2+) inhibit Ca(V)3.2 channels more efficiently than Ca(V)3.1 and Ca(V)3.3 channels via second high-affinity binding site including histidine H191 specific for the Ca(V)3.2 channel.	Histidine	170-179	calcium voltage-gated channel subunit alpha1 G	Homo sapiens	91-99
21382104-7	2011	The predicted peptide, with two typical motifs of Trp-Cys-Gly-His-Cys-Lys (WCGHCK) which is a hallmark of the PDI family, has high homology to that of bovine (99.21%), human (95.05%), rat (89.50%) and mouse (90.89%).	Histidine	62-65	prolyl 4-hydroxylase subunit beta	Bos taurus	110-113
22035583-6	2011	Alanine substitution of two amino acids, aspartic acid 127 and histidine 196 within the 5"-nucleotidase signature sequence, leads to reduced AMP or ADP hydrolysis but does not affect the binding of these substrates.	Histidine	63-72	5'-nucleotidase ecto	Homo sapiens	88-103
22018137-4	2011	RESULTS: Danio pol beta encoded by the in vitro/in vivo-compatible pIVEX plasmid was expressed in E. coli BL21(DE3), BL21(DE3)pLysS, and KRX, and in vitro as a C-terminal His-tagged protein.	Histidine	171-174	DNA polymerase beta	Rattus norvegicus	15-23
21884736-5	2011	The synthetic gene encoding human enteropeptidase light chain with His-tag added at the C-terminus to facilitate protein purification was cloned into Pichia pastoris expression plasmids under the control of an inducible AOX1 or constitutive promoters GAP and AAC.	Histidine	67-70	transmembrane serine protease 15	Homo sapiens	34-49
21813128-1	2011	OBJECTIVE: A gene polymorphism substituting arginine (R) for histidine (H) at position 131 has been described within the Fcgamma receptor IIa (FcgammaRIIa).	Histidine	61-70	Fc gamma receptor IIa	Homo sapiens	121-141
21813128-1	2011	OBJECTIVE: A gene polymorphism substituting arginine (R) for histidine (H) at position 131 has been described within the Fcgamma receptor IIa (FcgammaRIIa).	Histidine	61-70	Fc gamma receptor IIa	Homo sapiens	143-154
21470207-6	2011	We identified eight residues in the allosteric binding pocket that are crucial for non-competitive antagonism of agonist-dependent activation of mGlu2 and directly interact with the NAMs: Arg3 28, Arg3 29, Phe3 36, His(E2.52) , Leu5 43, Trp6 48, Phe6 55 and Val7 43.	Histidine	215-218	transient receptor potential cation channel subfamily C member 6	Homo sapiens	237-241
21757356-1	2011	Fragile histidine triad (Fhit) protein encoded by tumour suppressor FHIT gene is a proapoptotic protein with diadenosine polyphosphate (Ap(n)A, n=2-6) hydrolase activity.	Histidine	8-17	fragile histidine triad diadenosine triphosphatase	Homo sapiens	25-29
21757356-1	2011	Fragile histidine triad (Fhit) protein encoded by tumour suppressor FHIT gene is a proapoptotic protein with diadenosine polyphosphate (Ap(n)A, n=2-6) hydrolase activity.	Histidine	8-17	fragile histidine triad diadenosine triphosphatase	Homo sapiens	68-72
21673098-6	2011	The role of the dipeptides His-Ala and Tyr-Ala as DPP-4-generated GLP-1 and glucose-dependent insulinotropic peptide (GIP) degradation products was studied in vivo and in vitro on isolated islets.	Histidine	27-30	glucagon	Mus musculus	66-71
21673098-9	2011	Furthermore, the dipeptides liberated from GLP-1 (His-Ala) and GIP (Tyr-Ala) deteriorated glucose tolerance, reduced insulin, and increased portal glucagon levels.	Histidine	50-53	glucagon	Mus musculus	43-48
21718733-3	2011	Thyrotropin-releasing hormone (TRH, pGlu-His-Pro-NH(2)) may play a role in the pathophysiology and treatment of neuropsychiatric disorders such as major depression, and PTSD (an anxiety disorder).	Histidine	41-44	thyrotropin releasing hormone	Rattus norvegicus	0-29
21767494-1	2011	Rate-limiting millisecond motions in wild-type (WT) Ribonuclease A (RNase A) are modulated by histidine 48.	Histidine	94-103	ribonuclease A family member 1, pancreatic	Homo sapiens	52-66
21767494-1	2011	Rate-limiting millisecond motions in wild-type (WT) Ribonuclease A (RNase A) are modulated by histidine 48.	Histidine	94-103	ribonuclease A family member 1, pancreatic	Homo sapiens	68-75
21729333-6	2011	RESULTS: This analysis and two new crystal structures suggest that Ire1 RNase uses histidine H1061 and tyrosine Y1043 as the general acid-general base pair contributing &gt;=7.6 kcal/mol and 1.4 kcal/mol to transition state stabilization, respectively, and asparagine N1057 and arginine R1056 for coordination of the scissile phosphate.	Histidine	83-92	bifunctional endoribonuclease/protein kinase IRE1	Saccharomyces cerevisiae S288C	67-71
21719661-3	2011	However, their identification of histidine-84 of EF-Tu as deprotonating the catalytic water molecule is problematic in relation to their atomic structure; the terminal phosphate of GTP is more likely to be the proper proton acceptor.	Histidine	33-42	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	49-54
21866627-3	2011	pDEST26-His-Cdc42 was transfected by lipofectamine 2000 into SW480 and Colo320 cells with low expression of Cdc42.	Histidine	8-11	cell division cycle 42	Homo sapiens	12-17
21866627-3	2011	pDEST26-His-Cdc42 was transfected by lipofectamine 2000 into SW480 and Colo320 cells with low expression of Cdc42.	Histidine	8-11	cell division cycle 42	Homo sapiens	108-113
21543324-7	2011	Nevertheless, the catalytic cysteine and histidine residues constitute an active site that is highly similar to these in papain-like and nsP2 proteases.	Histidine	41-50	reticulon 2	Homo sapiens	137-141
21651864-7	2011	The fusion protein his-P58(IPK) was expressed in E.coli BL21 and purified using a his-tag protein purification column.	Histidine	19-22	dnaJ homolog subfamily C member 3	Sus scrofa	27-30
21486062-4	2011	Vibrational bands are assigned by comparison to histidine, phenylalanine, tyrosine, tryptophan, and 3-methylindole model compound data and by isotopic labeling of histidine in the beta2 subunit.	Histidine	163-172	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	180-185
20957682-5	2011	Upon treatment with histidine, a significant decrease in liver enzymes, ATX activities, and liver hydroxyproline was observed with a significant increase in plasma TAC in Group IV and a significant decrease in Group V. Histidine as an antioxidant has a protective effect on TAA-induced liver fibrosis; it is beneficial in rats not only by inhibition of collagen synthesis and increasing TAC but also by inhibition of ATX activities thus reducing its capacity to produce lysophosphatidic acid, which has a role in liver fibrosis.	Histidine	219-228	ectonucleotide pyrophosphatase/phosphodiesterase 2	Rattus norvegicus	72-75
20957682-5	2011	Upon treatment with histidine, a significant decrease in liver enzymes, ATX activities, and liver hydroxyproline was observed with a significant increase in plasma TAC in Group IV and a significant decrease in Group V. Histidine as an antioxidant has a protective effect on TAA-induced liver fibrosis; it is beneficial in rats not only by inhibition of collagen synthesis and increasing TAC but also by inhibition of ATX activities thus reducing its capacity to produce lysophosphatidic acid, which has a role in liver fibrosis.	Histidine	219-228	ectonucleotide pyrophosphatase/phosphodiesterase 2	Rattus norvegicus	417-420
21268659-9	2011	These results suggest that once PrP has entered the endosomal pathway, the acidic environment facilitates the binding of PrP(Sc) to the octarepeat of PrP(C) by the change in charge of the histidines within the octarepeat.	Histidine	188-198	prion protein	Mus musculus	32-35
21268659-9	2011	These results suggest that once PrP has entered the endosomal pathway, the acidic environment facilitates the binding of PrP(Sc) to the octarepeat of PrP(C) by the change in charge of the histidines within the octarepeat.	Histidine	188-198	prion protein	Mus musculus	121-124
21268659-9	2011	These results suggest that once PrP has entered the endosomal pathway, the acidic environment facilitates the binding of PrP(Sc) to the octarepeat of PrP(C) by the change in charge of the histidines within the octarepeat.	Histidine	188-198	prion protein	Mus musculus	121-124
21295540-6	2011	Using purified His-tagged AZ as a binding partner, we have purified the ODC:AZ inhibitory complex.	Histidine	15-18	ornithine decarboxylase 1	Homo sapiens	72-75
21214274-5	2011	Superimposition of active sites of the four simulated models (wild type and three variants) with the human TCII crystal structure revealed that the distance between the Nepsilon nitrogen atom of His-173 and the cobalt ion of cobalamin deviated considerably in the I5V model as compared to wild type and other variants.	Histidine	195-198	transcobalamin 2	Homo sapiens	107-111
21347309-4	2011	This domain comprises a pentapeptide sequence motif GxSxG/S at the N-terminus and conserved amino acid residues Ser, Asp and His that constitute a catalytic triad characteristic of lipase, esterase and cutinase activity.	Histidine	125-128	lipase	Mycobacterium tuberculosis H37Rv	181-187
21134455-2	2011	Histidine at position 1042 of the p150 region of the KRT vaccine strain was found to be responsible for ts, while wild-type viruses had tyrosine at position 1042 (Vaccine 27; 234-42, 2009).	Histidine	0-9	chromatin assembly factor 1 subunit A	Homo sapiens	34-38
21264317-6	2011	The two independent Spy0129 molecules in the crystal show differences in the positions and orientations of the catalytic Cys and His residues, Cys221 and His126, correlated with movements of the beta7/beta8 and beta4/beta5 loops that respectively follow these residues.	Histidine	129-132	FCT-2 pilus polymerization class B sortase SrtC1	Streptococcus pyogenes M1 GAS	20-27
21743838-1	2011	The Fragile Histidine Triad gene or FHIT functions as tumor suppressor in many epithelial cell types.	Histidine	12-21	fragile histidine triad diadenosine triphosphatase	Homo sapiens	36-40
22146730-2	2011	The putative processing enzyme, dipeptidyl peptidase IV, was expressed as a glycosylated His-tag fusion protein (rDPP-IV) via the baculovirus expression system.	Histidine	89-92	dipeptidylpeptidase 4	Rattus norvegicus	113-120
21058400-2	2011	Ngb can reversibly bind small ligands such as O2 and CO to the heme iron by replacing the distal histidine which is bound to the iron as the endogenous ligand.	Histidine	97-106	neuroglobin	Mus musculus	0-3
21851196-5	2011	The de novo novel mutation, c.1130A&gt;T (p.His377Leu), was identified; the mutation replaces histidine with leucine in the zinc finger (Znf) structure and is predicted to change the local spatial structure of the protein.	Histidine	94-103	zinc finger protein 763	Homo sapiens	124-135
21851196-5	2011	The de novo novel mutation, c.1130A&gt;T (p.His377Leu), was identified; the mutation replaces histidine with leucine in the zinc finger (Znf) structure and is predicted to change the local spatial structure of the protein.	Histidine	94-103	zinc finger protein 763	Homo sapiens	137-140
21208569-3	2011	The BALB/c mice were immuned with purified protein His-PCGF1-128/189 as antigen.	Histidine	51-54	polycomb group ring finger 1	Mus musculus	55-60
20884616-3	2010	We previously showed that NDPK-B activates the K(+) channel KCa3.1 via histidine phosphorylation of the C terminus of KCa3.1, which is required for T cell receptor-stimulated Ca(2+) flux and proliferation of activated naive human CD4 T cells.	Histidine	71-80	potassium calcium-activated channel subfamily N member 4	Homo sapiens	60-66
20884616-3	2010	We previously showed that NDPK-B activates the K(+) channel KCa3.1 via histidine phosphorylation of the C terminus of KCa3.1, which is required for T cell receptor-stimulated Ca(2+) flux and proliferation of activated naive human CD4 T cells.	Histidine	71-80	potassium calcium-activated channel subfamily N member 4	Homo sapiens	118-124
20934430-0	2010	Alternative oligomeric states of the yeast Rvb1/Rvb2 complex induced by histidine tags.	Histidine	72-81	RuvB family ATP-dependent DNA helicase pontin	Saccharomyces cerevisiae S288C	43-47
20934430-4	2010	We found that histidine-tagged constructs of yeast Rvb proteins employed in some of these studies induced the assembly of double hexameric ring Rvb1/Rvb2 complexes.	Histidine	14-23	RuvB family ATP-dependent DNA helicase pontin	Saccharomyces cerevisiae S288C	144-148
21041096-4	2010	The preferential hydrogen bonding network formation between His-12 and His-119 of RNase A with the polar carboxylic and amino groups of these compounds has been evidenced from the docking studies.	Histidine	60-63	ribonuclease A family member 1, pancreatic	Homo sapiens	82-89
21041096-4	2010	The preferential hydrogen bonding network formation between His-12 and His-119 of RNase A with the polar carboxylic and amino groups of these compounds has been evidenced from the docking studies.	Histidine	71-74	ribonuclease A family member 1, pancreatic	Homo sapiens	82-89
20843809-0	2010	Histidine residues in the Na+-coupled ascorbic acid transporter-2 (SVCT2) are central regulators of SVCT2 function, modulating pH sensitivity, transporter kinetics, Na+ cooperativity, conformational stability, and subcellular localization.	Histidine	0-9	solute carrier family 23 member 2	Homo sapiens	67-72
20843809-0	2010	Histidine residues in the Na+-coupled ascorbic acid transporter-2 (SVCT2) are central regulators of SVCT2 function, modulating pH sensitivity, transporter kinetics, Na+ cooperativity, conformational stability, and subcellular localization.	Histidine	0-9	solute carrier family 23 member 2	Homo sapiens	100-105
20843809-2	2010	SVCT2 contains six histidine residues in its primary sequence, three of which are exofacial in the transporter secondary structure model.	Histidine	19-28	solute carrier family 23 member 2	Homo sapiens	0-5
20843809-3	2010	We used site-directed mutagenesis and treatment with diethylpyrocarbonate to identify histidine residues responsible for SVCT2 pH sensitivity.	Histidine	86-95	solute carrier family 23 member 2	Homo sapiens	121-126
20843809-4	2010	We conclude that five histidine residues, His(109), His(203), His(206), His(269), and His(413), are central regulators of SVCT2 function, participating to different degrees in modulating pH sensitivity, transporter kinetics, Na(+) cooperativity, conformational stability, and subcellular localization.	Histidine	22-31	solute carrier family 23 member 2	Homo sapiens	122-127
20843809-4	2010	We conclude that five histidine residues, His(109), His(203), His(206), His(269), and His(413), are central regulators of SVCT2 function, participating to different degrees in modulating pH sensitivity, transporter kinetics, Na(+) cooperativity, conformational stability, and subcellular localization.	Histidine	42-45	solute carrier family 23 member 2	Homo sapiens	122-127
20843809-4	2010	We conclude that five histidine residues, His(109), His(203), His(206), His(269), and His(413), are central regulators of SVCT2 function, participating to different degrees in modulating pH sensitivity, transporter kinetics, Na(+) cooperativity, conformational stability, and subcellular localization.	Histidine	52-55	solute carrier family 23 member 2	Homo sapiens	122-127
20843809-4	2010	We conclude that five histidine residues, His(109), His(203), His(206), His(269), and His(413), are central regulators of SVCT2 function, participating to different degrees in modulating pH sensitivity, transporter kinetics, Na(+) cooperativity, conformational stability, and subcellular localization.	Histidine	52-55	solute carrier family 23 member 2	Homo sapiens	122-127
20843809-4	2010	We conclude that five histidine residues, His(109), His(203), His(206), His(269), and His(413), are central regulators of SVCT2 function, participating to different degrees in modulating pH sensitivity, transporter kinetics, Na(+) cooperativity, conformational stability, and subcellular localization.	Histidine	52-55	solute carrier family 23 member 2	Homo sapiens	122-127
20843809-4	2010	We conclude that five histidine residues, His(109), His(203), His(206), His(269), and His(413), are central regulators of SVCT2 function, participating to different degrees in modulating pH sensitivity, transporter kinetics, Na(+) cooperativity, conformational stability, and subcellular localization.	Histidine	52-55	solute carrier family 23 member 2	Homo sapiens	122-127
20843809-6	2010	Thus, histidine residues are central regulators of SVCT2 function.	Histidine	6-15	solute carrier family 23 member 2	Homo sapiens	51-56
20869730-3	2010	A homozygous missense mutation, causing a substitution of a molecule of arginine for histidine at the helicase domain of the senataxin protein, was found.	Histidine	85-94	senataxin	Homo sapiens	125-134
20952122-3	2010	Recently, the ferrous derivative of Alcaligenes xylosoxidans cytochrome c" (Axcyt c") and of cardiolipin-bound horse heart cytochrome c (CL-hhcyt c) have been reported to bind NO to the "dark side" of the heme (i.e., as the proximal axial ligand) replacing the endogenous ligand His.	Histidine	279-282	D-alanyl-D-alanine carboxypeptidase	Achromobacter xylosoxidans	61-73
20952122-3	2010	Recently, the ferrous derivative of Alcaligenes xylosoxidans cytochrome c" (Axcyt c") and of cardiolipin-bound horse heart cytochrome c (CL-hhcyt c) have been reported to bind NO to the "dark side" of the heme (i.e., as the proximal axial ligand) replacing the endogenous ligand His.	Histidine	279-282	D-alanyl-D-alanine carboxypeptidase	Achromobacter xylosoxidans	123-135
20711621-11	2010	Thus, histidine uniquely drives the pH-induced conformational change in the C-lobe required for TFR interaction, which in turn promotes iron release.	Histidine	6-15	transferrin receptor	Homo sapiens	96-99
20650903-2	2010	AtHMA4, an Arabidopsis thaliana heavy metal pump of importance for plant Zn(2+) nutrition, has an extended C-terminal domain containing 13 cysteine pairs and a terminal stretch of 11 histidines.	Histidine	183-193	heavy metal atpase 4	Arabidopsis thaliana	0-6
20650903-4	2010	When AtHMA4 is expressed in a Zn(2+)-sensitive zrc1 cot1 yeast strain, sequential removal of the histidine stretch and the cysteine pairs confers a gradual increase in Zn(2+) and Cd(2+) tolerance and lowered Zn(2+) and Cd(2+) content of transformed yeast cells.	Histidine	97-106	heavy metal atpase 4	Arabidopsis thaliana	5-11
20594158-2	2010	However, GLP-1 is rapidly degraded to GLP-1(9-36) by dipeptidyl peptidase-IV (DPP-IV), which removes the N-terminal dipeptide His(7)-Ala(8).	Histidine	126-129	glucagon	Mus musculus	9-14
20594158-2	2010	However, GLP-1 is rapidly degraded to GLP-1(9-36) by dipeptidyl peptidase-IV (DPP-IV), which removes the N-terminal dipeptide His(7)-Ala(8).	Histidine	126-129	glucagon	Mus musculus	38-43
20674369-5	2010	The pentagalactosylated dendrimer J4 betaGal(4)(Lys-Arg-His-Leu)(2)Dap-Thr-Tyr-His-Lys(betaGal)-Cys) selectively labels Jurkat cell as the fluorescein derivative J4F, but its colchicine conjugate J4C lacks cytotoxicity.	Histidine	56-59	death associated protein	Homo sapiens	67-70
20483643-5	2010	Analysis of bimolecular complexes of Venezuelan equine encephalitis virus (VEEV) nsP2 protease with each of the nsP1234 cleavage sites identified protease residues His(510), Ser(511), His(546) and Lys(706) as critical for cleavage site recognition.	Histidine	164-167	reticulon 2	Homo sapiens	81-85
20483643-5	2010	Analysis of bimolecular complexes of Venezuelan equine encephalitis virus (VEEV) nsP2 protease with each of the nsP1234 cleavage sites identified protease residues His(510), Ser(511), His(546) and Lys(706) as critical for cleavage site recognition.	Histidine	184-187	reticulon 2	Homo sapiens	81-85
20481504-0	2010	Straight-chain alkyl isocyanides open the distal histidine gate in crystal structures of myoglobin .	Histidine	49-58	myoglobin	Physeter catodon	89-98
20384362-6	2010	For each of the three lipids, we found a robust association and complete activity retention of two his(6)-modified proteins: a far red-fluorescent protein, monomeric Katushka (mKate), and a prodrug-converting enzyme, yeast cytosine deaminase (yCD).	Histidine	99-102	cytosine deaminase	Saccharomyces cerevisiae S288C	223-241
20421510-1	2010	A structural and functional model of bacterial nitric oxide reductase (NOR) has been designed by introducing two glutamates (Glu) and three histidines (His) in sperm whale myoglobin.	Histidine	152-155	myoglobin	Physeter catodon	172-181
20164530-4	2010	X-ray diffraction (1.9 A) revealed a GLTP fold with all key sugar headgroup recognition residues (Asp(66), Asn(70), Lys(73), Trp(109), and His(147)) conserved and properly oriented for glycolipid binding.	Histidine	139-142	glycolipid transfer protein	Homo sapiens	37-41
20180778-3	2010	The nucleophilic cysteine residue and the adjacent histidine residue, which are conserved in all active dual-specificity phosphatases, are replaced by serine and phenylalanine residues respectively in MK-STYX.	Histidine	51-60	serine/threonine/tyrosine interacting like 1	Homo sapiens	201-208
20180778-4	2010	Mutations to introduce histidine and cysteine residues into the active site of MK-STYX generated an active phosphatase.	Histidine	23-32	serine/threonine/tyrosine interacting like 1	Homo sapiens	79-86
20007405-4	2010	Kinetic assays measure metabolite levels by high-performance liquid chromatography separation with fluorescence detection by use of purified, histidine-tagged, human CBR3 wild type and variant enzymes.	Histidine	142-151	carbonyl reductase 3	Homo sapiens	166-170
19935706-1	2010	In many types of cancers, the fragile histidine triad (Fhit) gene is frequently targeted by genomic alterations leading to a decrease or loss of gene and protein expression.	Histidine	38-47	fragile histidine triad diadenosine triphosphatase	Homo sapiens	55-59
20088488-0	2010	The main role of inner histidines in the molecular mechanism of myoglobin oxidation catalyzed by copper compounds.	Histidine	23-33	myoglobin	Physeter catodon	64-73
20070118-1	2010	Cytochrome c oxidase (CcO), the terminal enzyme in the mitochondrial respiratory chain, catalyzes the four-electron reduction of dioxygen to water in a binuclear center comprised of a high-spin heme (heme a(3)) and a copper atom (Cu(B)) coordinated by three histidine residues.	Histidine	258-267	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	0-20
20070118-1	2010	Cytochrome c oxidase (CcO), the terminal enzyme in the mitochondrial respiratory chain, catalyzes the four-electron reduction of dioxygen to water in a binuclear center comprised of a high-spin heme (heme a(3)) and a copper atom (Cu(B)) coordinated by three histidine residues.	Histidine	258-267	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	22-25
20432945-6	2010	We also measured the enzymatic activity of recombinant protein (rADAMTS13) by GST-His two-site ELISA assay.	Histidine	82-85	ADAM metallopeptidase with thrombospondin type 1 motif, 13	Rattus norvegicus	64-73
19940152-5	2010	Mutation of the corresponding residue in Ca(v)3.1 to histidine, Gln(172), significantly enhances trace metal inhibition, but not to the level observed in wild-type Ca(v)3.2, implying that other residues also contribute to the metal binding site.	Histidine	53-62	calcium voltage-gated channel subunit alpha1 G	Homo sapiens	41-49
19940152-7	2010	The key findings of the study are that the metal binding site is composed of a Asp-Gly-His motif in IS3-S4 and a second aspartate residue in IS2.	Histidine	87-90	chromodomain helicase DNA binding protein 7	Homo sapiens	100-103
20944394-3	2010	Upon disruption of vba2, the uptake of several amino acids, including lysine, histidine, and arginine, was impaired.	Histidine	78-87	Vba2p	Saccharomyces cerevisiae S288C	19-23
20108989-5	2010	Peginterferon-alpha-2b has a linear 12 kDa PEG chain covalently attached primarily to histidine-34 of interferon-alpha-2b via an unstable urethane bond that is subject to hydrolysis once injected, releasing native interferon-alpha-2b.	Histidine	86-95	interferon alpha 2	Homo sapiens	3-22
20108989-5	2010	Peginterferon-alpha-2b has a linear 12 kDa PEG chain covalently attached primarily to histidine-34 of interferon-alpha-2b via an unstable urethane bond that is subject to hydrolysis once injected, releasing native interferon-alpha-2b.	Histidine	86-95	interferon alpha 2	Homo sapiens	102-121
19919057-2	2009	A lactam bridge-cyclized alpha-MSH peptide, DOTA-GlyGlu-CycMSH {DOTA-Gly-Glu-c[Lys-Nle-Glu-His-DPhe-Arg-Trp-Gly-Arg-Pro-Val-Asp]}, was synthesized and radiolabeled with 67Ga.	Histidine	91-94	pro-opiomelanocortin-alpha	Mus musculus	25-34
19834685-4	2009	[Arg(A0)]-HI induced a marked increase in the phosphotyrosine content of endosomal insulin receptor, coinciding with a more sustained endosomal association of growth factor receptor-bound protein 14 (GRB14), and a higher and prolonged activation of mitogen-activated protein kinase pathways.	Histidine	9-12	insulin receptor	Homo sapiens	83-99
19834685-9	2009	The endosomal conversion of [Arg(A0)]-HI into human insulin might extend the insulin receptor signalling at this locus.	Histidine	37-40	insulin receptor	Homo sapiens	77-93
19837749-2	2009	An (18)F-labeled linear alpha-MSH peptide ((18)F-FB-Ac-Nle-Asp-His-d-Phe-Arg-Trp-Gly-Lys-NH(2) [NAPamide]) shows promising melanoma imaging properties but with only moderate tumor uptake and retention.	Histidine	63-66	pro-opiomelanocortin-alpha	Mus musculus	24-33
19757839-2	2009	The substitution of the His(4)-Pro(5) dipeptide sequence by the constrained Trp analogue Aia-Gly, in combination with beta(2)hVal substitution at the N-terminus, provided a new stable analogue H-(R)-beta(2)hVal-Tyr-Ile-Aia-Gly-Phe-OH (AL-40) that is a potent ligand for the Ang IV receptor IRAP and selective versus AP-N and the AT1 receptor.	Histidine	24-27	alanyl aminopeptidase, membrane	Homo sapiens	316-320
19767579-5	2009	Mmp-20 cleaves amelogenin sequences after Pro(162), Ser(148), His(62), Ala(63), and Trp(45).	Histidine	62-65	matrix metallopeptidase 20	Sus scrofa	0-6
19728931-6	2009	In this study, mouse FADD (80-205) containing DD domain and C-terminal region, designated as C-FADD, was expressed in E. coli with His-tag at the N-terminus and purified by Ni2+ affinity chromatography.	Histidine	131-134	steroid sulfatase	Mus musculus	90-94
19418484-1	2009	Fragile histidine triad (FHIT) is a tumor suppressor gene whose allelic loss is associated to a number of human cancers.	Histidine	8-17	fragile histidine triad diadenosine triphosphatase	Homo sapiens	25-29
19540766-1	2009	Nucleoside-amino acid conjugates have been employed to inhibit the ribonucleolytic activity of ribonuclease A (RNase A) and affect the protonation/deprotonation equilibrium of its active site histidine residues.	Histidine	192-201	ribonuclease A family member 1, pancreatic	Homo sapiens	95-109
19540766-1	2009	Nucleoside-amino acid conjugates have been employed to inhibit the ribonucleolytic activity of ribonuclease A (RNase A) and affect the protonation/deprotonation equilibrium of its active site histidine residues.	Histidine	192-201	ribonuclease A family member 1, pancreatic	Homo sapiens	111-118
21966230-1	2009	Lipid-based nanoparticles (NPs) with a small amount of surface-chelated nickel (Ni-NPs) were developed to easily formulate the HIV his-tagged Tat protein, as well as to formulate and co-deliver two HIV antigens (his-p24 and his-Nef) on one particle.	Histidine	131-134	tyrosine aminotransferase	Mus musculus	142-145
21966230-2	2009	Female BALB/c mice were immunized by s.c. injection with his-Tat/Ni-NP formulation (1.5 mug Tat-his/mouse) and control formulations on day 0 and 14.	Histidine	57-60	tyrosine aminotransferase	Mus musculus	61-64
19268360-4	2009	We have cloned the human OFA/iLRP cDNA in a bacterial expression plasmid which incorporates a 6x HIS-tag.	Histidine	97-100	oncofetal antigen	Mus musculus	25-33
19304569-1	2009	Urocanase is an enzyme in the histidine pathway encoded by the UROC1 gene.	Histidine	30-39	urocanate hydratase 1	Homo sapiens	63-68
18817875-3	2009	In this work, an active C-terminal His-tagged UCH from Drosophila melanogaster (DmUCH) was produced as a secretory form in a recombinant strain of the methylotrophic yeast Pichia pastoris.	Histidine	35-38	Ubiquitin carboxy-terminal hydrolase	Drosophila melanogaster	46-49
19334611-7	2009	The replacement of glucose by galactose, or histidine starvation, partially restore the viability of sup35-AGG1 mutants, but not that of double mutants sup35-deltaAbf1,AGG1.	Histidine	44-53	translation termination factor GTPase eRF3	Saccharomyces cerevisiae S288C	101-106
18951909-6	2009	The residues involved in the formation of the inhibitory binding site on the 5-HT1A receptor were assessed by using N-ethyl-maleimide (NEM) or diethylpyrocarbonate (DEPC) which modify preferentially cysteine and histidine residues, respectively.	Histidine	212-221	5-hydroxytryptamine receptor 1A	Rattus norvegicus	77-83
19032942-3	2009	Here we show that CREB-binding protein (CBP)/p300-interacting transactivator with ED-rich tail 2 (Cited2), which binds to the cysteine-histidine-rich region 1 of p300 and CBP, regulates muscle mass in vitro.	Histidine	135-144	E1A binding protein p300	Homo sapiens	45-49
19032942-3	2009	Here we show that CREB-binding protein (CBP)/p300-interacting transactivator with ED-rich tail 2 (Cited2), which binds to the cysteine-histidine-rich region 1 of p300 and CBP, regulates muscle mass in vitro.	Histidine	135-144	E1A binding protein p300	Homo sapiens	162-166
18996422-0	2009	Histidine at position 1042 of the p150 region of a KRT live attenuated rubella vaccine strain is responsible for the temperature sensitivity.	Histidine	0-9	chromatin assembly factor 1 subunit A	Homo sapiens	34-38
18996422-11	2009	Thus, we concluded that one mutation, of the histidine at position 1042 of p150, was essential for the ts phenotype of the KRT strain, and structural proteins of KRT had an additive effect with H1042Y on the ts phenotype.	Histidine	45-54	chromatin assembly factor 1 subunit A	Homo sapiens	75-79
19514467-1	2009	The fragile histidine triad (Fhit) protein is a diadenosine triphosphate hydrolase belonging to the histidine triad family of nucleotide-binding proteins.	Histidine	12-21	fragile histidine triad diadenosine triphosphatase	Homo sapiens	29-33
19514467-1	2009	The fragile histidine triad (Fhit) protein is a diadenosine triphosphate hydrolase belonging to the histidine triad family of nucleotide-binding proteins.	Histidine	100-109	fragile histidine triad diadenosine triphosphatase	Homo sapiens	29-33
19074869-3	2008	We report a functional germline mutation (polymorphism) in the galectin-3 gene at position 191 (rs4644) substituting proline with histidine (P64H), which results in susceptibility to matrix metalloproteinase cleavage and acquisition of resistance to drug-induced apoptosis.	Histidine	130-139	galectin 3	Homo sapiens	63-73
18930707-5	2008	Moreover, addition of a hydrophilic epitope tag of 55-amino acids (V5-His) after the GPI signal of hCR-1 interfered with generation of a GPI-anchored form of hCR-1.	Histidine	70-73	complement C3b/C4b receptor 1 (Knops blood group)	Homo sapiens	99-104
18930707-5	2008	Moreover, addition of a hydrophilic epitope tag of 55-amino acids (V5-His) after the GPI signal of hCR-1 interfered with generation of a GPI-anchored form of hCR-1.	Histidine	70-73	complement C3b/C4b receptor 1 (Knops blood group)	Homo sapiens	158-163
18973745-2	2008	In the study reported here, N-terminal His-tags were added to the plastome-encoded alpha-subunit of cytochrome b559, PsbE, in tobacco plants, thus facilitating rapid, mild purification of higher plant PSII.	Histidine	39-42	cytochrome b559 alpha subunit	Nicotiana tabacum	117-121
19032907-7	2008	In addition, we found that HCBMCs generate the transcription of histidine decarboxylase (HDC), the enzyme responsible for the generation of histamine from histidine, after SP treatment.	Histidine	64-73	histidine decarboxylase	Homo sapiens	89-92
18634883-4	2008	In our system, a C-terminally 6x His-tagged variant of NCS-1 was co-expressed with yeast N-myristoyltransferase (NMT) in ZYP-5052 auto-induction media supplemented with sodium myristate (100-200 microM).	Histidine	33-36	neuronal calcium sensor 1	Homo sapiens	55-60
18771291-6	2008	These results support direct interactions of the Tyr (290(6.58)) side chain with Tyr (5) of GnRH I and His (5) of GnRH II.	Histidine	103-106	gonadotropin releasing hormone 2	Homo sapiens	114-121
18768683-6	2008	Of the 23 members of the aspartate-histidine-histidine-cysteine (DHHC) domain containing proteins, DHHC-7 most strongly stimulated palmitoylation of NCAM, and enzyme activity was enhanced by FGF2.	Histidine	35-44	zinc finger DHHC-type palmitoyltransferase 7	Homo sapiens	99-105
18676617-3	2008	The Cys- and His-rich repeated N terminus (CH domain) of Upf1 has been implicated in its binding to Upf2.	Histidine	13-16	Nmd2p	Saccharomyces cerevisiae S288C	100-104
18460012-1	2008	Diphthamide is a post-translational derivative of histidine in protein synthesis elongation factor-2 (eEF-2) that is present in all eukaryotes with no known normal physiological role.	Histidine	50-59	elongation factor 2	Cricetulus griseus	102-107
18595145-1	2008	AIM: To evaluate the inhibitory effects of human fragile histidine triad (FHIT) gene on cell proliferation and apoptosis in human hepatocellular carcinoma line Hep3B in vitro.	Histidine	57-66	fragile histidine triad diadenosine triphosphatase	Homo sapiens	74-78
17912498-8	2008	Our results revealed that urinary 8-OHdG level was higher in chewers with SULT1A1 Arg-His genotype than in chewers with SULT1A1 Arg-Arg genotype.	Histidine	86-89	sulfotransferase family 1A member 1	Homo sapiens	74-81
17926329-2	2008	Three-dimensional models of complexes of this receptor with alphaMSH and its synthetic analog NDP-alphaMSH, Ac-Ser(1)-Tyr(2)-Ser(3)-Nle(4)-Glu(5)-His(6)-D-Phe(7)-Arg(8)-Trp(9)-Gly(10)-Lys(11)-Pro(12)-Val(13)-NH(2), have been previously proposed.	Histidine	146-149	norrin cystine knot growth factor NDP	Homo sapiens	94-97
18227148-6	2008	The microsomal CYP1B1 protein level was significantly decreased for the Trp(365), Lys(387), and His(390) variants and was not detectable for the Ser(453) variant.	Histidine	96-99	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	15-21
18178100-8	2008	FRET analysis showed that his-ACBP directly interacted with HNF-4alpha (intermolecular distance of 73 A) at high affinity (K(d)=64-111 nM) similar to native ACBP.	Histidine	26-29	diazepam binding inhibitor	Mus musculus	30-34
18178100-10	2008	Thus, C-terminal his-tagged-ACBP maintained very similar structural and functional features of the untagged native protein and can be used in further in vitro experiments that require pure recombinant ACBP.	Histidine	17-20	diazepam binding inhibitor	Mus musculus	28-32
18178100-10	2008	Thus, C-terminal his-tagged-ACBP maintained very similar structural and functional features of the untagged native protein and can be used in further in vitro experiments that require pure recombinant ACBP.	Histidine	17-20	diazepam binding inhibitor	Mus musculus	201-205
18052938-3	2008	The present results show that in HepG2 human hepatoma cells, the total amount of C/EBPbeta protein, both the activating [LAP* and LAP (liver-enriched activating protein)] and inhibitory [LIP (liver-enriched inhibitory)] isoforms, was increased in histidine-deprived cells.	Histidine	247-256	CCAAT enhancer binding protein beta	Homo sapiens	81-90
17965265-1	2008	Histamine, a biogenic amine with important biological functions, is produced from histidine by histidine decarboxylase (HDC), a pyridoxal 5"-phosphate-dependent enzyme.	Histidine	82-91	histidine decarboxylase	Homo sapiens	95-118
17965265-1	2008	Histamine, a biogenic amine with important biological functions, is produced from histidine by histidine decarboxylase (HDC), a pyridoxal 5"-phosphate-dependent enzyme.	Histidine	82-91	histidine decarboxylase	Homo sapiens	120-123
17965265-5	2008	The most potent inhibitory compound among nine tested structural variants was the pyridoxyl-histidine methyl ester conjugate (PHME), indicating that the binding site of hHDC does not tolerate groups other than the imidazole side chain of histidine.	Histidine	92-101	histidine decarboxylase	Homo sapiens	169-173
18179643-2	2008	Two allelic dimorphisms of these receptors, valine/phenylalanine-158 of CD16A and histidine/arginine-131 of CD32A, modulate their affinity for certain human IgG subclasses.	Histidine	82-91	Fc gamma receptor IIa	Homo sapiens	108-113
18197705-5	2008	In this study the two T3 Cu coordinating His residues which lie in this pathway in Fet3 have been mutated, H483Q, H483C, H485Q, and H485C, to study how perturbation at the TNC impacts the T1 Cu site.	Histidine	41-44	ferroxidase FET3	Saccharomyces cerevisiae S288C	83-87
17990982-8	2008	TRAC-1 and its relatives were found to contain, apart from the RING domain, a C2HC (Cys(2)-His-Cys)- and two C2H2 (Cys(2)-His(2))-type zinc fingers, as well as a UIM (ubiquitin-interacting motif).	Histidine	91-94	ring finger protein 125	Homo sapiens	0-6
18085635-7	2008	LE and CN Cx43 was lower than the IAS (P &lt; 0.05) and the RE, LNB, and His all expressed Cx43 similarly, with approximately half of IAS expression (RE: 44 +/- 36%; LNB: 50 +/- 26%; His: 48 +/- 12%, P = NS compared with IAS).	Histidine	73-76	gap junction protein alpha 1	Homo sapiens	91-95
18085635-9	2008	Cx43 was found in myocytes of the human AVJ, and its expression pattern delineates two separate continuous structures: one consists of the LE and CN with little Cx43, and the other consists of the His, LNB, and RE expressing approximately half the Cx43 of the IAS.	Histidine	197-200	gap junction protein alpha 1	Homo sapiens	0-4
17965457-4	2008	Because two of these amino acids (Cys and His) are members of the catalytic triad of human BAT, it was proposed that 4HNE would cause inactivation of this enzyme.	Histidine	42-45	bile acid-CoA:amino acid N-acyltransferase	Homo sapiens	91-94
17978863-3	2008	Human Ke 6 gene was expressed as an enzymatically-active His-tag fusion protein, whose molecular weight was estimated to be 32.5 kDa by SDS-polyacrylamide gel electrophoresis.	Histidine	57-60	hydroxysteroid 17-beta dehydrogenase 8	Homo sapiens	6-10
18069127-5	2008	Competition experiments showed [3-Me-His(2)]TRH potently displaced [(3)H][3-Me-His(2)]TRH binding from all tissues/cells investigated.	Histidine	37-40	thyrotropin releasing hormone	Rattus norvegicus	44-47
18069127-5	2008	Competition experiments showed [3-Me-His(2)]TRH potently displaced [(3)H][3-Me-His(2)]TRH binding from all tissues/cells investigated.	Histidine	37-40	thyrotropin releasing hormone	Rattus norvegicus	86-89
18069127-5	2008	Competition experiments showed [3-Me-His(2)]TRH potently displaced [(3)H][3-Me-His(2)]TRH binding from all tissues/cells investigated.	Histidine	79-82	thyrotropin releasing hormone	Rattus norvegicus	44-47
18069127-5	2008	Competition experiments showed [3-Me-His(2)]TRH potently displaced [(3)H][3-Me-His(2)]TRH binding from all tissues/cells investigated.	Histidine	79-82	thyrotropin releasing hormone	Rattus norvegicus	86-89
17936057-6	2008	Interestingly, the interaction of both isoforms with Shp2 in vivo was found using stable cell lines expressing eEF1A1-His or eEF1A2-His.	Histidine	118-121	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	111-117
18776324-4	2008	To clarify the pH-dependent binding mechanism of TLR3 at the structural level, we focused on 3 highly conserved histidine residues clustered at the N-terminal region of the TLR3 ectodomain (ECD): H39, H60 and H108.	Histidine	112-121	toll like receptor 3	Homo sapiens	49-53
18776324-4	2008	To clarify the pH-dependent binding mechanism of TLR3 at the structural level, we focused on 3 highly conserved histidine residues clustered at the N-terminal region of the TLR3 ectodomain (ECD): H39, H60 and H108.	Histidine	112-121	toll like receptor 3	Homo sapiens	173-177
18038314-1	2008	AIM: To investigate the relationship of fragile histidine triad (FHIT) and Ki-67 expression with clinicopathological variables of patients with malignant pleural mesothelioma (MPM).	Histidine	48-57	fragile histidine triad diadenosine triphosphatase	Homo sapiens	65-69
18165525-2	2007	A genetic single nucleotide polymorphism in the Fc gamma RIIa gene, resulting in arginine (R) or histidine (H) at position 131, affects the binding to the different IgG subclasses and may influence the clinical variations seen in onchocerciasis.	Histidine	97-106	Fc gamma receptor IIa	Homo sapiens	48-61
17870088-0	2007	Evidence that human histidine triad nucleotide binding protein 3 (Hint3) is a distinct branch of the histidine triad (HIT) superfamily.	Histidine	20-29	histidine triad nucleotide binding protein 3	Homo sapiens	66-71
17870088-1	2007	Human Hint3 (hHint3) has been classified as a member of the histidine triad nucleotide (Hint) binding protein subfamily.	Histidine	60-69	histidine triad nucleotide binding protein 3	Homo sapiens	6-11
17870088-1	2007	Human Hint3 (hHint3) has been classified as a member of the histidine triad nucleotide (Hint) binding protein subfamily.	Histidine	60-69	histidine triad nucleotide binding protein 3	Homo sapiens	13-19
17870088-13	2007	In contrast to all previously characterized members of the histidine triad superfamily, which have been shown to exist exclusively as homodimers, wild type and the H145A of hHint3-1 were found to exist across a range of multimeric states, from dimers to octamers and even larger oligomers, while wild type and the H145A of hHint3-2 exist predominantly in a monomeric state.	Histidine	59-68	histidine triad nucleotide binding protein 3	Homo sapiens	173-179
17870088-15	2007	Taken together, these results imply that while Hint3 and Hint1 prefer aminoacyl-adenylates as substrates and catalytically interact with aminoacyl-tRNA synthetases, the significant differences in phosphoramidase activity, oligomeric state, and cellular localization suggest that Hint3s should be placed in a distinct branch of the histidine triad superfamily.	Histidine	331-340	histidine triad nucleotide binding protein 3	Homo sapiens	47-52
17974981-1	2007	The fragile histidine triad (FHIT) gene has been shown to function as a tumor suppressor gene in vitro and in vivo.	Histidine	12-21	fragile histidine triad diadenosine triphosphatase	Homo sapiens	29-33
17804496-5	2007	These studies showed that nucleotides bind inside a cleft between the two domains of NSP2 in a region that exhibits structural similarity to ubiquitous cellular HIT (histidine triad) proteins.	Histidine	166-175	reticulon 2	Homo sapiens	85-89
17690095-12	2007	The simulations show how chiral discriminations arises from the structures, with two AspRS conformations acting in different ways and proton uptake by nearby histidines playing a role.	Histidine	158-168	aspartyl-tRNA synthetase 1	Homo sapiens	85-90
17825837-5	2007	The pH dependency is due to the conserved histidine residues of the ENTH and ANTH domains, protonation of which is necessary for the strong PtdIns(4,5)P2 recognition, as revealed by liposome binding, surface plasmon resonance, NMR, monolayer surface tension and mutagenesis experiments.	Histidine	42-51	clathrin interactor 1	Homo sapiens	68-72
17880074-4	2007	Among the four types of cation charge sites, protonated histidine showed the highest degree of ET, no D, while no apparent intact electron-transfer products were observed for peptides with protonated lysine or arginine.	Histidine	56-65	atrophin 1	Homo sapiens	99-103
17846065-3	2007	The histidine-tagged mutants (delta-4, -8, -12 and -16) were overexpressed in E. coli BL21 (DE3) and purified in a stable form by nickel affinity chromatography except for one mutant (delta-16).	Histidine	4-13	delta like canonical Notch ligand 4	Rattus norvegicus	30-41
17482256-1	2007	To develop a culture substrate that allows efficient expansion of neural stem cells (NSCs), epidermal growth factor (EGF) was immobilized onto the Ni(II)-chelated surface of a glass-based substrate through coordination of Ni(II) to the histidine tag that was fused to the C-terminal of EGF using recombinant technology.	Histidine	236-245	epidermal growth factor like 1	Rattus norvegicus	92-115
17482256-1	2007	To develop a culture substrate that allows efficient expansion of neural stem cells (NSCs), epidermal growth factor (EGF) was immobilized onto the Ni(II)-chelated surface of a glass-based substrate through coordination of Ni(II) to the histidine tag that was fused to the C-terminal of EGF using recombinant technology.	Histidine	236-245	epidermal growth factor like 1	Rattus norvegicus	117-120
17694439-1	2007	Abnormality in the fragile histidine triade (FHIT), a candidate tumor suppressor gene located in chromosome region 3 (3p14.2), has been frequently found in multiple tumor types, including lung cancer.	Histidine	27-36	fragile histidine triad diadenosine triphosphatase	Homo sapiens	45-49
17611644-8	2007	In addition, the IgH-CDR3 of anti-GPI Ab-positive patients was rich in basic-ionized amino acids (arginine, histidine, and lysine) near their central position, suggesting a high affinity.	Histidine	108-117	immunoglobulin heavy locus	Homo sapiens	17-20
17611644-8	2007	In addition, the IgH-CDR3 of anti-GPI Ab-positive patients was rich in basic-ionized amino acids (arginine, histidine, and lysine) near their central position, suggesting a high affinity.	Histidine	108-117	CDR3	Homo sapiens	21-25
17611644-8	2007	In addition, the IgH-CDR3 of anti-GPI Ab-positive patients was rich in basic-ionized amino acids (arginine, histidine, and lysine) near their central position, suggesting a high affinity.	Histidine	108-117	glucose-6-phosphate isomerase	Homo sapiens	34-37
17499643-1	2007	A conformationally constrained peptidomimetic derived from the endocrine and neuroactive tripeptide thyrotropin-releasing hormone (pGlu-His-Pro-NH(2)) was synthesized by convenient solid-phase organic chemistry and evaluated as a potential central nervous system agent.	Histidine	136-139	thyrotropin releasing hormone	Homo sapiens	100-129
17310323-0	2007	Expression and simple, one-step purification of fragile histidine triad (Fhit) tumor suppressor mutant forms in Escherichia coli and their interaction with protoporphyrin IX.	Histidine	56-65	fragile histidine triad diadenosine triphosphatase	Homo sapiens	73-77
17310323-1	2007	The product of human fragile histidine triad (FHIT) gene is a tumor suppressor protein of still largely unknown cellular background.	Histidine	29-38	fragile histidine triad diadenosine triphosphatase	Homo sapiens	46-50
17310323-3	2007	Fhit, diadenosine triphosphate (Ap3A) hydrolase, possesses the active site with histidine triad His-phi-His-phi-His-phiphi.	Histidine	80-89	fragile histidine triad diadenosine triphosphatase	Homo sapiens	0-4
17310323-3	2007	Fhit, diadenosine triphosphate (Ap3A) hydrolase, possesses the active site with histidine triad His-phi-His-phi-His-phiphi.	Histidine	96-99	fragile histidine triad diadenosine triphosphatase	Homo sapiens	0-4
17310323-3	2007	Fhit, diadenosine triphosphate (Ap3A) hydrolase, possesses the active site with histidine triad His-phi-His-phi-His-phiphi.	Histidine	104-107	fragile histidine triad diadenosine triphosphatase	Homo sapiens	0-4
17310323-3	2007	Fhit, diadenosine triphosphate (Ap3A) hydrolase, possesses the active site with histidine triad His-phi-His-phi-His-phiphi.	Histidine	104-107	fragile histidine triad diadenosine triphosphatase	Homo sapiens	0-4
17310323-4	2007	So-called histidine Fhit mutants (His94Asn, His96Asn and His98Asn) exhibit highly reduced activity in vitro, however, their antitumor function has not been fully described yet.	Histidine	10-19	fragile histidine triad diadenosine triphosphatase	Homo sapiens	20-24
17548701-1	2007	Many studies have established that loss of heterozygosity and/or altered expression of the fragile histidine triad (FHIT) gene is a common event in a number of tumor types including prostate carcinoma.	Histidine	99-108	fragile histidine triad diadenosine triphosphatase	Homo sapiens	116-120
17470807-7	2007	The model identifies key ionic and hydrophobic interactions at the binding interface, including hydrogen-bonding between His-87 of actin to Ser-89 of cofilin that may control the charge dependence of cofilin binding.	Histidine	121-124	cofilin 1	Homo sapiens	150-157
17470807-7	2007	The model identifies key ionic and hydrophobic interactions at the binding interface, including hydrogen-bonding between His-87 of actin to Ser-89 of cofilin that may control the charge dependence of cofilin binding.	Histidine	121-124	cofilin 1	Homo sapiens	200-207
17470809-0	2007	A histidine residue acting as a controlling site for dioxygen reduction and proton pumping by cytochrome c oxidase.	Histidine	2-11	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	94-114
17470809-3	2007	Here, we report a coupling mechanism by a histidine (His-503) at the entrance of a proton transfer pathway to the dioxygen reduction site (D-pathway) of bovine heart cytochrome c oxidase.	Histidine	42-51	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	166-186
17470809-3	2007	Here, we report a coupling mechanism by a histidine (His-503) at the entrance of a proton transfer pathway to the dioxygen reduction site (D-pathway) of bovine heart cytochrome c oxidase.	Histidine	53-56	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	166-186
17485849-5	2007	Then we found that among AS2/LOB family members, ASL9 is distinct from the others in that it is exclusively regulated by the plant hormone cytokinin in a manner dependent on His-Asp phosphorelay signal transduction.	Histidine	174-177	Lateral organ boundaries (LOB) domain family protein	Arabidopsis thaliana	25-28
17485849-5	2007	Then we found that among AS2/LOB family members, ASL9 is distinct from the others in that it is exclusively regulated by the plant hormone cytokinin in a manner dependent on His-Asp phosphorelay signal transduction.	Histidine	174-177	Lateral organ boundaries (LOB) domain family protein	Arabidopsis thaliana	29-32
17485849-5	2007	Then we found that among AS2/LOB family members, ASL9 is distinct from the others in that it is exclusively regulated by the plant hormone cytokinin in a manner dependent on His-Asp phosphorelay signal transduction.	Histidine	174-177	ASYMMETRIC LEAVES 2-like 9	Arabidopsis thaliana	49-53
24557667-1	2007	The fragile histidine triad (FHIT) gene, a candidate tumor suppressor gene located at 3p14.2, has been shown to be involved in the carcinogenesis of many human tissues, including digestive tract tissues.	Histidine	12-21	fragile histidine triad diadenosine triphosphatase	Homo sapiens	29-33
17376561-2	2007	Most of the synthetic analogs of alphaMSH, including a broadly used and more potent the NDP-alphaMSH peptide, Ac-Ser(1)-Tyr-Ser-Nle(4)-Glu-His(6)-D-Phe(7)-Arg(8)-Trp(9)-Gly-Lys-Pro-Val(13)-NH(2), are also not particularly selective for MC5R.	Histidine	139-142	norrin cystine knot growth factor NDP	Homo sapiens	88-91
17363702-10	2007	We conclude that the receptor-independent activation of G proteins via NDPK B/Gbetagamma complexes requires the intermediate phosphorylation of G protein beta subunits at His-266.	Histidine	171-174	NME/NM23 nucleoside diphosphate kinase 2	Rattus norvegicus	71-77
17385893-12	2007	This places the Sec residue farther away from the protonating histidine residue, but the lower pKa of Sec in comparison to that of Cys eliminates the need for Sec to be protonated.	Histidine	62-71	eukaryotic elongation factor, selenocysteine-tRNA-specific	Mus musculus	16-19
17401213-3	2007	The wild-type dimeric RepE protein was expressed as an N-terminal histidine-tagged protein, purified under native conditions with a high salt concentration and crystallized in complex with the repE operator DNA using the sitting-drop vapour-diffusion technique.	Histidine	66-75	replication initiation protein of the FIA replicon	Escherichia coli	22-26
17241641-6	2007	The interaction between the two proteins was confirmed using GST-HAX-1, bound to the glutathione-matrix, which specifically adsorbed native PLN from human or mouse cardiac homogenates, while in reciprocal binding studies, recombinant His-HAX-1 bound GST-PLN.	Histidine	234-237	HCLS1 associated protein X-1	Homo sapiens	65-70
17164404-11	2007	These novel results show that the formation of 4-HNE-Erk-1/2 monomer-adducts results in the inhibition of Erk-Elk-AP-1 signaling in hepatocytes and implicates the His 178 residue with the mechanism of inhibition.	Histidine	163-166	mitogen activated protein kinase 3	Rattus norvegicus	53-60
17380463-1	2007	OBJECTIVE: To investigate the relationship between the expression of fragile histidine triad (FHIT) protein and the clinicopathological characteristics of rectal carcinoma.	Histidine	77-86	fragile histidine triad diadenosine triphosphatase	Homo sapiens	94-98
16973378-2	2007	Human adenylosuccinate lyase was overexpressed in Escherichia coli Rosetta 2(DE3)pLysS as an N-terminal histidine-tagged protein and was purified to homogeneity by a nickel-nitriloacetic acid column at room temperature.	Histidine	104-113	adenylosuccinate lyase	Homo sapiens	6-28
16973378-3	2007	The histidine tag was removed from the human enzyme by thrombin digestion and the adenylosuccinate lyase was purified by Sephadex G-100 gel filtration.	Histidine	4-13	adenylosuccinate lyase	Homo sapiens	82-104
17227057-1	2007	Histidine decarboxylase (HDC) catalyzes histamine formation from histidine.	Histidine	65-74	histidine decarboxylase	Homo sapiens	0-23
17227057-1	2007	Histidine decarboxylase (HDC) catalyzes histamine formation from histidine.	Histidine	65-74	histidine decarboxylase	Homo sapiens	25-28
17227057-4	2007	Epicatechin gallate (ECG) was found to be a potent inhibitor as it inhibited HDC activity in a competitive manner with Ki = 10 muM against l-histidine.	Histidine	139-150	histidine decarboxylase	Homo sapiens	77-80
17210913-8	2007	Modeling a tetrapeptide substrate in the context of the rhomboid structure reveals an oxyanion hole comprising the side chain of a second conserved histidine and the main-chain NH of the nucleophilic serine residue.	Histidine	148-157	rhomboid	Drosophila melanogaster	56-64
17584126-3	2007	Our initial efforts in this area have focused on affinity and selectivity directed optimization of the native beta-MSH(5-22) sequence and resulted in the discovery of a potent MC4R agonist: Ac-Tyr-Arg-[Cys-Glu-His-D-Phe-Arg-Trp-Cys]-NH(2) (10).	Histidine	210-213	pro-opiomelanocortin-alpha	Mus musculus	110-118
17179900-0	2007	Investigation of the catalytic and structural roles of conserved histidines of human coproporphyrinogen oxidase using site-directed mutagenesis.	Histidine	65-75	coproporphyrinogen oxidase	Homo sapiens	85-111
17179900-1	2007	BACKGROUND: The catalytic contribution of four conserved histidines of human coproporphyrinogen oxidase (CPO) has been investigated using site-directed mutagenesis to change histidine (H) into alanine (A).	Histidine	57-67	coproporphyrinogen oxidase	Homo sapiens	77-103
17179900-1	2007	BACKGROUND: The catalytic contribution of four conserved histidines of human coproporphyrinogen oxidase (CPO) has been investigated using site-directed mutagenesis to change histidine (H) into alanine (A).	Histidine	57-66	coproporphyrinogen oxidase	Homo sapiens	77-103
17609151-8	2007	This chapter provides a brief overview of such techniques, describes their use in confirming histidine phosphorylation of a known PTS protein (HPr), and suggests how this approach might be adapted for large-scale identification of histidine-phosphorylated proteins in two-component systems.	Histidine	93-102	haptoglobin-related protein	Homo sapiens	143-146
17713357-6	2007	We also found increased histidine decarboxylase (HDC) expression in activated HUCMC after 6 h of incubation, a rate-limiting enzyme responsible for the generation of histamine from histidine.	Histidine	24-33	histidine decarboxylase	Homo sapiens	49-52
17143956-1	2006	AIM: To investigate the expression of fragile histidine triad (FHIT) protein in 64 patients with ulcerative colitis (UC) and Crohn"s disease (CD), and its relation with clinicopathological data.	Histidine	46-55	fragile histidine triad diadenosine triphosphatase	Homo sapiens	63-67
16963188-3	2006	With the introduction of an N-terminal Kozak sequence and a C-terminal (His)(6)-tag, a yield of 1 mg of Atm1p was obtained from 3 g wet yeast cells, which is comparable to other membrane-associated proteins isolated from eukaryotic expression systems.	Histidine	72-75	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	104-109
17107382-2	2006	OBJECTIVES: As recent data suggested the fragile histidine triad (FHIT) gene product to participate in DNA damage responses we wished to address whether functional deletion of this tumour suppressor participates in the development of BCC.	Histidine	49-58	fragile histidine triad diadenosine triphosphatase	Homo sapiens	66-70
24362350-5	2014	Docking studies further demonstrate the interaction of their polar amino group with the P1 site residues of angiogenin, i.e., His-13 and His-114 residues.	Histidine	126-129	angiogenin	Homo sapiens	108-118
24362350-5	2014	Docking studies further demonstrate the interaction of their polar amino group with the P1 site residues of angiogenin, i.e., His-13 and His-114 residues.	Histidine	137-140	angiogenin	Homo sapiens	108-118
24396396-1	2014	The aim of this study was to investigate the methylation status of fragile histidine triad (FHIT) and the effects of FHIT on cell growth and cyclin D1 expression in hepatoma cells.	Histidine	75-84	fragile histidine triad diadenosine triphosphatase	Homo sapiens	92-96
24296672-1	2014	Aminoimidazole carboxamide ribotide (AICAR) is a purine biosynthetic intermediate and a by-product of histidine biosynthesis.	Histidine	102-111	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	Homo sapiens	37-42
24357096-9	2014	RESULTS: The results suggests a protective effect of the genotypes Arg/Lys of AhR rs2066853 (odds ratio [OR] 0.55, p = 0.03), Ile/Val of CYP1A1 rs1048943 (OR 0.49, p = 0.009), Tyr/His of EPHX1 rs1051740 (OR 0.53, p = 0.03), and A/A of CCND1 rs603965 (OR 0.44, p = 0.02).	Histidine	180-183	aryl hydrocarbon receptor	Homo sapiens	78-81
25422218-1	2014	Fragile histidine triad (FHIT) is a suppressor gene related to cervical cancer through CpG island hypermethylation.	Histidine	8-17	fragile histidine triad diadenosine triphosphatase	Homo sapiens	25-29
25430456-2	2014	Molecular modeling of PPDKs from divergent organisms demonstrates that the orientation of the phosphorylatable histidine residue within the central domain of PPDK determines whether this enzyme promotes catabolism or gluconeogenesis.	Histidine	111-120	pyruvate, phosphate dikinase 1, chloroplastic	Zea mays	22-26
24714493-5	2014	Modification of MICOS subunits Mic12 or Mic26 by His-tags in the absence of Aim24 leads to complete loss of cristae and respiratory complexes.	Histidine	49-52	antigen identified by monoclonal antibody 30.2A8	Homo sapiens	31-36
24809174-3	2014	It was shown that distribution of LMP2 allelic variants was the following: Arg/Arg - 53.3%, Arg/His - 43.5%, His/His - 6.7% in control and Arg/Arg - 55.9%, Arg/His - 34.3%, His/His - 9.8% in IS group (P &gt; 0.05).	Histidine	96-99	proteasome 20S subunit beta 9	Homo sapiens	34-38
24809174-3	2014	It was shown that distribution of LMP2 allelic variants was the following: Arg/Arg - 53.3%, Arg/His - 43.5%, His/His - 6.7% in control and Arg/Arg - 55.9%, Arg/His - 34.3%, His/His - 9.8% in IS group (P &gt; 0.05).	Histidine	109-112	proteasome 20S subunit beta 9	Homo sapiens	34-38
24809174-3	2014	It was shown that distribution of LMP2 allelic variants was the following: Arg/Arg - 53.3%, Arg/His - 43.5%, His/His - 6.7% in control and Arg/Arg - 55.9%, Arg/His - 34.3%, His/His - 9.8% in IS group (P &gt; 0.05).	Histidine	109-112	proteasome 20S subunit beta 9	Homo sapiens	34-38
24809174-3	2014	It was shown that distribution of LMP2 allelic variants was the following: Arg/Arg - 53.3%, Arg/His - 43.5%, His/His - 6.7% in control and Arg/Arg - 55.9%, Arg/His - 34.3%, His/His - 9.8% in IS group (P &gt; 0.05).	Histidine	109-112	proteasome 20S subunit beta 9	Homo sapiens	34-38
24809174-3	2014	It was shown that distribution of LMP2 allelic variants was the following: Arg/Arg - 53.3%, Arg/His - 43.5%, His/His - 6.7% in control and Arg/Arg - 55.9%, Arg/His - 34.3%, His/His - 9.8% in IS group (P &gt; 0.05).	Histidine	109-112	proteasome 20S subunit beta 9	Homo sapiens	34-38
24809174-3	2014	It was shown that distribution of LMP2 allelic variants was the following: Arg/Arg - 53.3%, Arg/His - 43.5%, His/His - 6.7% in control and Arg/Arg - 55.9%, Arg/His - 34.3%, His/His - 9.8% in IS group (P &gt; 0.05).	Histidine	109-112	proteasome 20S subunit beta 9	Homo sapiens	34-38
24349317-5	2013	Interestingly, Gln(40) and His(64) on ECP formed a clamp-like structure to stabilize Hep6 in our model, which was not observed in the corresponding residues on EDN.	Histidine	27-30	ribonuclease A family member 2	Homo sapiens	160-163
23994584-5	2013	However, particular alleles at GM 23 and FcgammaRIIa loci interactively contributed to the risk of this malignancy (p = 0.031), the odds ratios ranging from 0.44 in subjects homozygous for the GM 23- allele at the IgG2 locus and for the histidine allele at the FcgammaRIIa locus to 2.86 in subjects homozygous for the GM 23+ allele at the IgG2 locus and the histidine allele at the FcgammaRIIa locus.	Histidine	237-246	Fc gamma receptor IIa	Homo sapiens	41-52
23994584-5	2013	However, particular alleles at GM 23 and FcgammaRIIa loci interactively contributed to the risk of this malignancy (p = 0.031), the odds ratios ranging from 0.44 in subjects homozygous for the GM 23- allele at the IgG2 locus and for the histidine allele at the FcgammaRIIa locus to 2.86 in subjects homozygous for the GM 23+ allele at the IgG2 locus and the histidine allele at the FcgammaRIIa locus.	Histidine	358-367	Fc gamma receptor IIa	Homo sapiens	41-52
23974721-5	2013	In the current study, we indicated that DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked (DDX3X) is an immunogenic protein preferentially expressed in CD133(+) tumor cells.	Histidine	64-67	DEAD-box helicase 3 X-linked	Homo sapiens	98-103
24043698-6	2013	http://dx.doi.org/10.1083/jcb.201308034) show that pHi increase activates FAK by causing deprotonation of histidine 58 in its FERM (band 4.1, ezrin, radixin, moesin) homology domain, which exposes a region important for FAK autophosphorylation.	Histidine	106-115	glucose-6-phosphate isomerase	Homo sapiens	51-54
24043698-6	2013	http://dx.doi.org/10.1083/jcb.201308034) show that pHi increase activates FAK by causing deprotonation of histidine 58 in its FERM (band 4.1, ezrin, radixin, moesin) homology domain, which exposes a region important for FAK autophosphorylation.	Histidine	106-115	protein tyrosine kinase 2	Homo sapiens	74-77
24043698-6	2013	http://dx.doi.org/10.1083/jcb.201308034) show that pHi increase activates FAK by causing deprotonation of histidine 58 in its FERM (band 4.1, ezrin, radixin, moesin) homology domain, which exposes a region important for FAK autophosphorylation.	Histidine	106-115	protein tyrosine kinase 2	Homo sapiens	220-223
23884414-8	2013	Furthermore, inhibition by 30 muM ZnCl2 was impaired in TRPM5 mutants in which His at 896, and Glu at 926 and/or Glu at 939 in the outer pore loop were replaced with Gln.	Histidine	79-82	transient receptor potential cation channel subfamily M member 5	Homo sapiens	56-61
16985102-12	2006	The increase in catalytic efficiency observed for Pro360 in human FMO3 was also observed when the His of FMO1 was replaced by Pro at loci 360.	Histidine	98-101	flavin containing dimethylaniline monoxygenase 1	Homo sapiens	105-109
17018532-3	2006	We investigated the binding reaction between PSD-95 PDZ3 and a peptide corresponding to a native ligand with protein engineering in conjunction with stopped-flow and equilibrium fluorimetry and found that the two conserved residues Arg-318 and His-372 were responsible for the salt and pH dependencies, respectively.	Histidine	244-247	discs large MAGUK scaffold protein 4	Homo sapiens	45-51
17018532-8	2006	Both chloride concentration and pH (during ischemia) vary in the postsynaptic density, where PSD-95 is present, and the physiological buffer conditions may thus modulate the interaction between PSD-95 and its ligands through binding of chloride and protons to the "molecular switches" Arg-318 and His-372, respectively.	Histidine	297-300	discs large MAGUK scaffold protein 4	Homo sapiens	93-99
17018532-8	2006	Both chloride concentration and pH (during ischemia) vary in the postsynaptic density, where PSD-95 is present, and the physiological buffer conditions may thus modulate the interaction between PSD-95 and its ligands through binding of chloride and protons to the "molecular switches" Arg-318 and His-372, respectively.	Histidine	297-300	discs large MAGUK scaffold protein 4	Homo sapiens	194-200
28636006-7	2017	The main Cu(ii) anchoring site of Ang is His-114, where metal binding inhibits RNase activity of the protein.	Histidine	41-44	angiogenin	Homo sapiens	34-37
17382535-1	2006	Fragile histidine triad (FHIT) gene, a candidate tumor suppressor gene located at 3p14.2, has been shown to be involved in carcinogenesis of many human tissues, including digestive tract tissues.	Histidine	8-17	fragile histidine triad diadenosine triphosphatase	Homo sapiens	25-29
28302724-6	2017	These results, together with the previous results for the mutants of the His ligands of PD1 and PD2, lead to a definite conclusion that a charge is mainly localized to PD1 in P680&lt;sup/&gt;.	Histidine	73-76	programmed cell death 1	Homo sapiens	88-91
17055384-1	2006	Histamine is a low-molecular-weight amine, synthesized from l-histidine by histidine decarboxylase.	Histidine	60-71	histidine decarboxylase	Mus musculus	75-98
23797051-3	2013	Here, we attempt to corroborate and provide further insight pertinent to the fragile histidine triad (FHIT) gene in microsatellite instable (MSI), microsatellite stable (MSS), and CpG island methylator phenotype (CIMP) CRC subtypes.	Histidine	85-94	fragile histidine triad diadenosine triphosphatase	Homo sapiens	102-106
23270585-3	2013	The genetic locus of Fc-gamma RIIA consists of two allelic genes: 131-Arg (R131) and 131-His (H131).	Histidine	89-92	Fc gamma receptor IIa	Homo sapiens	21-34
28302724-6	2017	These results, together with the previous results for the mutants of the His ligands of PD1 and PD2, lead to a definite conclusion that a charge is mainly localized to PD1 in P680&lt;sup/&gt;.	Histidine	73-76	programmed cell death 1	Homo sapiens	168-171
16735073-4	2006	In order to obtain human LOX-1 and identify its mimic ligand for facilitating the study of LOX-1 function, a recombinant plasmid pPIC9K-His-hLOX-1 was structured and expressed human LOX-1 in Pichia pastoris GS115.	Histidine	136-139	oxidized low density lipoprotein receptor 1	Homo sapiens	140-146
28414724-2	2017	In this study, sequence alignment revealed that the His-Asp-Ser catalytic triad is embedded in the TAAHC-DIAL-GDSGGP sequence motif, establishing Bm-SP142 as a serine protease.	Histidine	52-55	serine protease	Bombyx mori	160-175
16967187-8	2006	All these findings suggested that the fused expressed His-DR inhibited the activity of natural DDR2, and relevant MMP-1 and MMP-2 expression in synoviocytes and NIH3T3 cells provoked by collagen II.	Histidine	54-57	matrix metallopeptidase 13	Mus musculus	114-119
25509392-9	2013	In the LH2 complex, coordination of bacteriochlorophyll Mg2+ by conservative histidine residues of the alpha and beta polypeptides is the main factor responsible for the maintenance of its cylindrical structure.	Histidine	77-86	LIM homeobox 2	Homo sapiens	7-10
28414756-0	2017	Reduction in the copy number and expression level of the recurrent human papillomavirus integration gene fragile histidine triad (FHIT) predicts the transition of cervical lesions.	Histidine	113-122	fragile histidine triad diadenosine triphosphatase	Homo sapiens	130-134
23864225-0	2013	Mechanism of activation of elongation factor Tu by ribosome: catalytic histidine activates GTP by protonation.	Histidine	71-80	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	27-47
28202392-2	2017	It is usually composed of three proteins or protein complexes, enzyme I, HPr, and enzyme II, which are phosphorylated at histidine or cysteine residues.	Histidine	121-130	haptoglobin-related protein	Homo sapiens	73-76
23610131-5	2013	Here, we studied the role of different His residues, predicted within TMDs or ECLs of MCT8, in substrate recognition and translocation.	Histidine	39-42	solute carrier family 16 member 2	Homo sapiens	86-90
16934294-0	2006	Histidine triad-like motif of the rotavirus NSP2 octamer mediates both RTPase and NTPase activities.	Histidine	0-9	reticulon 2	Homo sapiens	44-48
28272426-7	2017	For the new strain, histidine hydrogen-deuterium mass spectrometry revealed altered packing arrangements of beta-sheets that encompass residues 139 and 186 of PrPSc.	Histidine	20-29	prion protein	Mus musculus	159-164
16978018-8	2006	KIAA1363 reactivates faster than AChE presumably due to differences in the uncoupling of the catalytic triad His upon phosphorylation.	Histidine	109-112	acetylcholinesterase	Mus musculus	33-37
16895604-2	2006	The two most commonly expressed fragile sites FRA3B and FRA16D host the histidine triad (FHIT) and WW domain containing oxidoreductase (WWOX) genes respectively.	Histidine	72-81	fragile histidine triad diadenosine triphosphatase	Homo sapiens	46-51
16895604-2	2006	The two most commonly expressed fragile sites FRA3B and FRA16D host the histidine triad (FHIT) and WW domain containing oxidoreductase (WWOX) genes respectively.	Histidine	72-81	fragile histidine triad diadenosine triphosphatase	Homo sapiens	89-93
23653353-2	2013	Although His-69 within the furin prodomain serves as the pH sensor that detects transport of the propeptide-enzyme complex to the trans-Golgi network, where it promotes cleavage and release of the inhibitory propeptide, a mechanistic understanding of how His-69 protonation mediates furin activation remains unclear.	Histidine	9-12	furin, paired basic amino acid cleaving enzyme	Homo sapiens	27-32
23653353-2	2013	Although His-69 within the furin prodomain serves as the pH sensor that detects transport of the propeptide-enzyme complex to the trans-Golgi network, where it promotes cleavage and release of the inhibitory propeptide, a mechanistic understanding of how His-69 protonation mediates furin activation remains unclear.	Histidine	9-12	furin, paired basic amino acid cleaving enzyme	Homo sapiens	283-288
23653353-2	2013	Although His-69 within the furin prodomain serves as the pH sensor that detects transport of the propeptide-enzyme complex to the trans-Golgi network, where it promotes cleavage and release of the inhibitory propeptide, a mechanistic understanding of how His-69 protonation mediates furin activation remains unclear.	Histidine	255-258	furin, paired basic amino acid cleaving enzyme	Homo sapiens	27-32
23653353-4	2013	Structural analyses and binding experiments comparing the wild-type furin propeptide with a nonprotonatable His-69   Leu mutant that blocks furin activation in vivo revealed protonation of His-69 reduces both the thermodynamic stability of the propeptide as well as its affinity for furin at pH 6.0.	Histidine	108-111	furin, paired basic amino acid cleaving enzyme	Homo sapiens	140-145
23653353-4	2013	Structural analyses and binding experiments comparing the wild-type furin propeptide with a nonprotonatable His-69   Leu mutant that blocks furin activation in vivo revealed protonation of His-69 reduces both the thermodynamic stability of the propeptide as well as its affinity for furin at pH 6.0.	Histidine	108-111	furin, paired basic amino acid cleaving enzyme	Homo sapiens	140-145
16863736-2	2006	The fragile histidine triad (FHIT) gene is considered a tumor suppressor gene in different human epithelial cancers.	Histidine	12-21	fragile histidine triad diadenosine triphosphatase	Homo sapiens	29-33
28057518-2	2017	Here, we report on X-ray analyses of human apo- and holo-CRBP1, showing nearly identical structures, at variance with the results of a recent study on the same proteins containing a His-Tag, which appears to be responsible for a destabilizing effect on the apoprotein.	Histidine	182-185	retinol binding protein 1	Homo sapiens	57-62
16777221-10	2006	The selective modulation of CaV3.2 by G-proteins, CaMKII and PKA is determined by the II-III linker and the high-affinity inhibition of CaV3.2 by Ni2+ relies on a histidine residue in the IS3-S4 linker.	Histidine	163-172	calcium voltage-gated channel subunit alpha1 H	Homo sapiens	28-34
23653353-5	2013	Structural modeling combined with mathematical modeling and molecular dynamic simulations suggested that His-69 does not directly contribute to the propeptide-enzyme interface but, rather, triggers movement of a loop region in the propeptide that modulates access to the cleavage site and, thus, allows for the tight pH regulation of furin activation.	Histidine	105-108	furin, paired basic amino acid cleaving enzyme	Homo sapiens	334-339
23653353-6	2013	Our work establishes a mechanism by which His-69 functions as a pH sensor that regulates compartment-specific furin activation and provides insights into how other convertases and proteases may regulate their precise spatiotemporal activation.	Histidine	42-45	furin, paired basic amino acid cleaving enzyme	Homo sapiens	110-115
16777221-10	2006	The selective modulation of CaV3.2 by G-proteins, CaMKII and PKA is determined by the II-III linker and the high-affinity inhibition of CaV3.2 by Ni2+ relies on a histidine residue in the IS3-S4 linker.	Histidine	163-172	calcium voltage-gated channel subunit alpha1 H	Homo sapiens	136-142
23640895-8	2013	Removal of the histidine-rich domain (RL1-DeltaHis) or entire intracellular sequence (RL1-DeltaC) resulted in greater retention at the plasma membrane and significantly reduced ligand-independent ERK1/2 responses.	Histidine	15-24	mitogen-activated protein kinase 3	Mus musculus	196-202
28165386-5	2017	Markedly, oxidative modifications of MNSOD were identified at histidine (H54 and H55), tyrosine (Y58), tryptophan (W147, W149, W205 and W210) and asparagine (N206 and N209) residues additional to methionine.	Histidine	62-71	superoxide dismutase 2	Homo sapiens	37-42
23664973-6	2013	Domain-swapping and site-directed mutagenesis of GCY-14 reveal that GCY-14 functions as a homodimer, in which histidine of the extracellular domains plays a crucial role in alkalinity detection.	Histidine	110-119	Receptor-type guanylate cyclase gcy-14	Caenorhabditis elegans	49-55
16873255-3	2006	NSP2 of the rotavirus group causing endemic infantile diarrhea (group A) was shown to self-assemble into large doughnut-shaped octamers with circumferential grooves and deep clefts containing nucleotide-binding histidine triad (HIT)-like motifs.	Histidine	211-220	reticulon 2	Homo sapiens	0-4
16611635-2	2006	Pyroglutamyl peptidase II (PPII), a highly specific membrane-bound omegapeptidase, removes N-terminal pyroglutamyl from thyrotropin-releasing hormone (&lt;Glu-His-Pro-NH(2)), inactivating the peptide in the extracellular space.	Histidine	159-162	thyrotropin releasing hormone	Homo sapiens	120-149
16910776-4	2006	To examine this question, we used site-directed mutagenesis to produce a mutant form of human MnSOD that has a leucine at amino acid 26 in the active site rather than the usual histidine.	Histidine	177-186	superoxide dismutase 2	Homo sapiens	94-99
23664973-6	2013	Domain-swapping and site-directed mutagenesis of GCY-14 reveal that GCY-14 functions as a homodimer, in which histidine of the extracellular domains plays a crucial role in alkalinity detection.	Histidine	110-119	Receptor-type guanylate cyclase gcy-14	Caenorhabditis elegans	68-74
27774581-5	2017	Patients with psoriasis showed a strong association for IL17F rs763780 [odds ratio (OR) = 3 27, P = 0 04], which results in a histidine-to-arginine substitution, and JAK2 rs2274471 (OR = 2 66, P = 0 02).	Histidine	126-135	interleukin 17F	Homo sapiens	56-61
23280549-4	2013	Biochemical pull down assays using secreted GDF-15 and His-tagged CCN2 produced in PC-3 prostate cancer cells confirmed a direct interaction between these proteins.	Histidine	55-58	cellular communication network factor 2	Homo sapiens	66-70
16563127-11	2006	To further examine the requirement of C/EBPbeta in OM-stimulated LDLR expression, we developed a His-tagged dominant-negative mutant of C/EBPbeta (His-C/EBPbeta-P4; where P4 is plasmid 4 in our mutation series), consisting of the DNA-binding and leucine zipper domains of C/EBPbeta (amino acids 246-345).	Histidine	147-150	CCAAT enhancer binding protein beta	Homo sapiens	136-145
28030949-0	2017	Human Neuronal Calcium Sensor-1 Protein Avoids Histidine Residues To Decrease pH Sensitivity.	Histidine	47-56	neuronal calcium sensor 1	Homo sapiens	6-31
16563127-11	2006	To further examine the requirement of C/EBPbeta in OM-stimulated LDLR expression, we developed a His-tagged dominant-negative mutant of C/EBPbeta (His-C/EBPbeta-P4; where P4 is plasmid 4 in our mutation series), consisting of the DNA-binding and leucine zipper domains of C/EBPbeta (amino acids 246-345).	Histidine	147-150	CCAAT enhancer binding protein beta	Homo sapiens	136-145
16563127-11	2006	To further examine the requirement of C/EBPbeta in OM-stimulated LDLR expression, we developed a His-tagged dominant-negative mutant of C/EBPbeta (His-C/EBPbeta-P4; where P4 is plasmid 4 in our mutation series), consisting of the DNA-binding and leucine zipper domains of C/EBPbeta (amino acids 246-345).	Histidine	147-150	CCAAT enhancer binding protein beta	Homo sapiens	136-145
16749776-1	2006	Peptide dendrimers built by iteration of the diamino acid dendron Dap-His-Ser (His = histidine, Ser = Serine, Dap = diamino propionic acid) display a strong positive dendritic effect for the catalytic hydrolysis of 8-acyloxypyrene 1,3,6-trisulfonates, which proceeds with enzyme-like kinetics in aqueous medium (Delort, E.; Darbre, T.; Reymond, J.-L. J.	Histidine	70-73	death associated protein	Homo sapiens	66-69
23443656-3	2013	Herein, we produced recombinant histidine-tagged Toxoplasma gondii MIF (TgMIF), a 12-kDa protein that lacks oxidoreductase activity but exhibits tautomerase activity with a specific activity of 19.3 mumol/min/mg that cannot be inhibited by the human MIF inhibitor ISO-1.	Histidine	32-41	macrophage migration inhibitory factor	Homo sapiens	67-70
16749776-1	2006	Peptide dendrimers built by iteration of the diamino acid dendron Dap-His-Ser (His = histidine, Ser = Serine, Dap = diamino propionic acid) display a strong positive dendritic effect for the catalytic hydrolysis of 8-acyloxypyrene 1,3,6-trisulfonates, which proceeds with enzyme-like kinetics in aqueous medium (Delort, E.; Darbre, T.; Reymond, J.-L. J.	Histidine	70-73	death associated protein	Homo sapiens	110-113
28030949-8	2017	This study highlights the conformational dynamics effects of the R102H and S83H mutations on the local structural flexibility and global stability of NCS-1, whereas protonated histidine decreases the stability of NCS-1.	Histidine	176-185	neuronal calcium sensor 1	Homo sapiens	213-218
16749776-1	2006	Peptide dendrimers built by iteration of the diamino acid dendron Dap-His-Ser (His = histidine, Ser = Serine, Dap = diamino propionic acid) display a strong positive dendritic effect for the catalytic hydrolysis of 8-acyloxypyrene 1,3,6-trisulfonates, which proceeds with enzyme-like kinetics in aqueous medium (Delort, E.; Darbre, T.; Reymond, J.-L. J.	Histidine	85-94	death associated protein	Homo sapiens	66-69
16749776-1	2006	Peptide dendrimers built by iteration of the diamino acid dendron Dap-His-Ser (His = histidine, Ser = Serine, Dap = diamino propionic acid) display a strong positive dendritic effect for the catalytic hydrolysis of 8-acyloxypyrene 1,3,6-trisulfonates, which proceeds with enzyme-like kinetics in aqueous medium (Delort, E.; Darbre, T.; Reymond, J.-L. J.	Histidine	85-94	death associated protein	Homo sapiens	110-113
28951869-2	2017	mTAT, a TAT peptide sequence bearing histidine and cysteine residues, has been successfully used for intracellular gene delivery.	Histidine	37-46	tyrosine aminotransferase	Mus musculus	1-4
16380267-2	2006	The sequence corresponding to the mature lipase was subcloned in the pET-14b expression vector, with a strong T7 promoter, to construct a recombinant lipase protein containing six histidine residues at the N-terminal.	Histidine	180-189	YSIRK-type signal peptide-containing protein	Staphylococcus xylosus	41-47
16380267-2	2006	The sequence corresponding to the mature lipase was subcloned in the pET-14b expression vector, with a strong T7 promoter, to construct a recombinant lipase protein containing six histidine residues at the N-terminal.	Histidine	180-189	YSIRK-type signal peptide-containing protein	Staphylococcus xylosus	150-156
22760783-4	2013	CaCDPK1 expressed as histidine-tag fusion protein was purified using Ni-NTA affinity chromatography till homogeneity.	Histidine	21-30	calcium-dependent protein kinase 21-like	Cicer arietinum	0-7
27893431-2	2016	TDP1-mediated hydrolysis uses a nucleophilic histidine (Hisnuc) and a general acid/base histidine (Hisgab).	Histidine	45-54	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	0-4
23461587-4	2013	The major differences between the QM/MM optimized active sites of WT MnSOD and Mn(Fe)SOD are a smaller (His)N-Mn-N(His) equatorial angle and a longer (Gln146(69))NH   O(sol) H-bond distance in the metal-substituted protein.	Histidine	104-107	superoxide dismutase 2	Homo sapiens	69-74
23461587-4	2013	The major differences between the QM/MM optimized active sites of WT MnSOD and Mn(Fe)SOD are a smaller (His)N-Mn-N(His) equatorial angle and a longer (Gln146(69))NH   O(sol) H-bond distance in the metal-substituted protein.	Histidine	104-107	superoxide dismutase 2	Homo sapiens	71-74
16607661-4	2006	The significant enhancement of the scattering intensity of QDs observed upon conjugation with the P450(BSbeta) due to the refractive-index increment and the systematic variation in zeta potential resulting from charge neutralization of the anionic QDs by the cationic histidine-tagged P450(BSbeta) have been used for stoichiometry determination.	Histidine	268-277	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	98-110
27808173-4	2016	Moreover, bFGF treatment corrected diabetes-induced reductions in citrate, lactate, choline, glycine, creatine, histidine, phenylalanine, tyrosine and glutamine in serum.	Histidine	112-121	fibroblast growth factor 2	Rattus norvegicus	10-14
16407838-1	2006	The Fhit tumor suppressor binds and hydrolyses diadenosine polyphosphates and the Fhit-substrate complex has been proposed as a proapoptotic effector, as determined by infection of susceptible cancer cells with adenoviruses carrying wild-type fragile histidine triad (FHIT) or catalytic site mutants.	Histidine	251-260	fragile histidine triad diadenosine triphosphatase	Homo sapiens	4-8
16407838-1	2006	The Fhit tumor suppressor binds and hydrolyses diadenosine polyphosphates and the Fhit-substrate complex has been proposed as a proapoptotic effector, as determined by infection of susceptible cancer cells with adenoviruses carrying wild-type fragile histidine triad (FHIT) or catalytic site mutants.	Histidine	251-260	fragile histidine triad diadenosine triphosphatase	Homo sapiens	82-86
23407638-6	2013	The inhibited complex was recovered with residues 1-60 of bovine IF1 with a C-terminal green fluorescent protein followed by a His-tag, and the active enzyme with the same inhibitor with a C-terminal glutathione-S-transferase domain.	Histidine	127-130	ATP synthase inhibitory factor subunit 1	Bos taurus	65-68
23385758-1	2013	Histidine-containing phosphotransfer proteins from Arabidopsis thaliana (AHP1-5) act as intermediates between sensor histidine kinases and response regulators in a signalling system called multi-step phosphorelay (MSP).	Histidine	0-9	histidine-containing phosphotransmitter 1	Arabidopsis thaliana	73-77
27809838-5	2016	METHODS: ATP-dependent DNA helicase gene (PfRuvB3) of Plasmodium falciparum strain K1, a chloroquine and pyrimethamine-resistant strain, was inserted into pQE-TriSystem His-Strep 2 vector, heterologously expressed and affinity purified.	Histidine	169-172	helicase for meiosis 1	Homo sapiens	27-35
23195954-2	2013	We demonstrate unknown facets of calnuc, which is a serine protease in which Ser-378 of GXSXG motif, Asp-328 of DTG motif, and His-339 form the "catalytic triad," locating the enzyme active site in the C-terminal region.	Histidine	127-130	nucleobindin 1	Homo sapiens	33-39
16800968-1	2006	BACKGROUND: The fragile histidine triad (FHIT) gene is located at 3p14.2, a region frequently lost in various tumor types.	Histidine	24-33	fragile histidine triad diadenosine triphosphatase	Homo sapiens	41-45
27693831-2	2016	The human amylin is shown to interact with zinc ions with major contribution from the single histidine residue, which is absent in amylin from other species such as cat, rhesus and rodents.	Histidine	93-102	islet amyloid polypeptide	Homo sapiens	10-16
16777001-0	2006	[Expression of fragile histidine triad (FHIT) protein and its significance in diagnosing classical Hodgkin lymphoma].	Histidine	23-32	fragile histidine triad diadenosine triphosphatase	Homo sapiens	40-44
23276281-6	2013	This analysis, combined with studies of mutant proteins, suggests that four histidine residues (H17 and H27 of S100A8; H91 and H95 of S100A9) coordinate Mn(II) in addition to two as-yet unidentified ligands.	Histidine	76-85	S100 calcium binding protein A8	Homo sapiens	111-117
23534718-0	2013	Expression of fragile histidine triad (FHIT) and WW-domain oxidoreductase gene (WWOX) in nasopharyngeal carcinoma.	Histidine	22-31	fragile histidine triad diadenosine triphosphatase	Homo sapiens	39-43
27693831-2	2016	The human amylin is shown to interact with zinc ions with major contribution from the single histidine residue, which is absent in amylin from other species such as cat, rhesus and rodents.	Histidine	93-102	islet amyloid polypeptide	Homo sapiens	131-137
15935551-1	2006	The fragile histidine triad (FHIT), located in chromosome region 3p14.2, had been reported to be a frequent allele with loss of heterozygosity (LOH) in smoking lung cancer and HPV-associated cervical cancer.	Histidine	12-21	fragile histidine triad diadenosine triphosphatase	Homo sapiens	29-33
27541598-3	2016	CP has two distinct transition-metal-binding sites formed at the S100A8/S100A9 dimer interface, including a histidine-rich site composed of S100A8 residues His17 and His27 and S100A9 residues His91 and His95.	Histidine	108-117	S100 calcium binding protein A8	Homo sapiens	140-146
16539846-10	2006	CONCLUSION: IL-28 and IL-29 cDNAs were successfully cloned and expressed in eukaryotic cells via transfection with pcDNA3.1/V5-His-TOPO-IL-28/IL-29.	Histidine	127-130	interferon lambda 1	Homo sapiens	22-27
27711373-3	2016	BACE1 is a catalytic Asp dyad [Asp, Asp-] containing aspartyl protease, while IDE and BILAP are mononuclear [Zn(His, His, Glu)] and binuclear [Zn1(Asp, Glu, Asp)-Zn2(Lys, Glu, Asp, Asp)] core possessing metallopeptidases, respectively.	Histidine	112-115	insulin degrading enzyme	Bos taurus	78-81
16696901-3	2006	In present study, the extracellular domain of human PD-1 with a carboxyl terminal His-tag (designated as sPD-1) was expressed as inclusion bodies in Escherichia coli.	Histidine	82-85	programmed cell death 1	Homo sapiens	52-56
22940581-5	2013	Here we determined kinetic and structural properties of POP with mutations in loop A, loop B, and in two additional flexible loops (the catalytic His loop, propeller Asp/Glu loop).	Histidine	146-149	prolyl endopeptidase	Homo sapiens	56-59
27711373-3	2016	BACE1 is a catalytic Asp dyad [Asp, Asp-] containing aspartyl protease, while IDE and BILAP are mononuclear [Zn(His, His, Glu)] and binuclear [Zn1(Asp, Glu, Asp)-Zn2(Lys, Glu, Asp, Asp)] core possessing metallopeptidases, respectively.	Histidine	117-120	insulin degrading enzyme	Bos taurus	78-81
23200251-1	2013	Mutation of amino acid residues 94, 96 and 119 to histidine(s) in the human carbonic anhydrase (CA, EC 4.2.1.1) related proteins CARP VIII, X and XI restored the zinc binding and catalytic activity for the hydration of CO(2) to bicarbonate.	Histidine	50-59	cytochrome c oxidase subunit 8A	Homo sapiens	134-138
27537339-0	2016	Caprine PrP variants harboring Asp-146, His-154 and Gln-211 alleles display reduced convertibility upon interaction with pathogenic murine prion protein in scrapie infected cells.	Histidine	40-43	prion protein	Mus musculus	8-11
23163895-6	2013	The introduction of point mutations at the "active site" of MK-STYX that convert serine and phenylalanine to histidine and cysteine, respectively, is sufficient to generate an active enzyme.	Histidine	109-118	serine/threonine/tyrosine interacting like 1	Homo sapiens	60-67
16875543-10	2006	Data from multivariate analysis showed that the allele of SULT1A1 His and CYP19 (TTTA)10 was positively associated with the risk of breast cancer.	Histidine	66-69	sulfotransferase family 1A member 1	Homo sapiens	58-65
27537339-3	2016	Field studies identified scrapie-protective caprine PrP variants, harboring specific single amino acid changes (Met-142, Arg-143, Asp-146, Ser-146, His-154, Gln-211 and Lys-222).	Histidine	148-151	prion protein	Mus musculus	52-55
27346274-9	2016	Mutagenesis of each amino acid difference in EC1 between BB3 receptor/BB2 receptor showed replacement of His(107) in BB3 receptor by Lys(107) (H107K-BB3 receptor-mutant) from BB2 receptor, decreased affinity 60-fold, and three replacements [H107K, E11D, G112R] decreased affinity 500-fold.	Histidine	105-108	bombesin receptor subtype 3	Homo sapiens	57-60
23443232-1	2012	AIM: To characterize aberrant crypt focus (ACF) in adjoining mucosa in sporadic colorectal carcinoma and to evaluate fragile histidine triad (Fhit) protein and Ki67.	Histidine	125-134	fragile histidine triad diadenosine triphosphatase	Homo sapiens	142-146
27346274-9	2016	Mutagenesis of each amino acid difference in EC1 between BB3 receptor/BB2 receptor showed replacement of His(107) in BB3 receptor by Lys(107) (H107K-BB3 receptor-mutant) from BB2 receptor, decreased affinity 60-fold, and three replacements [H107K, E11D, G112R] decreased affinity 500-fold.	Histidine	105-108	bombesin receptor subtype 3	Homo sapiens	117-120
27346274-9	2016	Mutagenesis of each amino acid difference in EC1 between BB3 receptor/BB2 receptor showed replacement of His(107) in BB3 receptor by Lys(107) (H107K-BB3 receptor-mutant) from BB2 receptor, decreased affinity 60-fold, and three replacements [H107K, E11D, G112R] decreased affinity 500-fold.	Histidine	105-108	bombesin receptor subtype 3	Homo sapiens	117-120
22628489-3	2012	Among them, a functional FCGR2A polymorphism leading to amino acid change of histidine (H) to arginine (R) at position 131 appears to be a major candidate in adult invasive pneumococcal diseases (IPDs).	Histidine	77-86	Fc gamma receptor IIa	Homo sapiens	25-31
27464742-1	2016	This study is focused on a new amide derivative of the peptide HLDF-6 (Thr-Gly-Glu-Asn-His-Arg).	Histidine	87-90	ribosomal protein S21	Homo sapiens	63-67
23046926-4	2012	A novel mutation at codon 163 was found in PSEN1, which was changed from histidine to proline.	Histidine	73-82	presenilin 1	Homo sapiens	43-48
27542194-0	2016	Histidine phosphorylation relieves copper inhibition in the mammalian potassium channel KCa3.1.	Histidine	0-9	potassium calcium-activated channel subfamily N member 4	Homo sapiens	88-94
27542194-2	2016	KCa3.1 is unique among these four channels in that activation requires, in addition to calcium, phosphorylation of a single histidine residue (His358) in the cytoplasmic region, by nucleoside diphosphate kinase-B (NDPK-B).	Histidine	124-133	potassium calcium-activated channel subfamily N member 4	Homo sapiens	0-6
27542194-3	2016	The mechanism by which KCa3.1 is activated by histidine phosphorylation is unknown.	Histidine	46-55	potassium calcium-activated channel subfamily N member 4	Homo sapiens	23-29
22782802-8	2012	Poly-His (His-tag)-containing peptides, fused to the UGT C terminus, allow sensitive immunodetection of expressed enzymes with monoclonal antibodies.	Histidine	5-8	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	53-56
27542194-6	2016	Furthermore, we show that activated CD4(+) T cells deficient in intracellular copper exhibit increased KCa3.1 histidine phosphorylation and channel activity, leading to increased calcium flux and cytokine production.	Histidine	110-119	potassium calcium-activated channel subfamily N member 4	Homo sapiens	103-109
27247265-3	2016	Previous in vitro studies revealed that palmitoylation of NCAM is required for fibroblast growth factor 2 (FGF2)-stimulated neurite outgrowth and identified the zinc finger DHHC (Asp-His-His-Cys)-containing proteins ZDHHC3 and ZDHHC7 as specific NCAM-palmitoylating enzymes.	Histidine	183-186	zinc finger DHHC-type palmitoyltransferase 7	Homo sapiens	227-233
27247265-3	2016	Previous in vitro studies revealed that palmitoylation of NCAM is required for fibroblast growth factor 2 (FGF2)-stimulated neurite outgrowth and identified the zinc finger DHHC (Asp-His-His-Cys)-containing proteins ZDHHC3 and ZDHHC7 as specific NCAM-palmitoylating enzymes.	Histidine	187-190	zinc finger DHHC-type palmitoyltransferase 7	Homo sapiens	227-233
27328714-8	2016	Indirect ELISA revealed the ability of the sfGFP-AhR, but not the sfGFP, to bind to the immobilized dioxin with the possibility to detect such interaction by both its 6 x His and GFP tags,Competitive ELISA showed that anti-dioxin antibody was more sensitive to low dioxin concentrations than sfGFP-AhR.	Histidine	171-174	aryl hydrocarbon receptor	Homo sapiens	49-52
22805477-5	2012	METHODS: Recombinant HMW-glutenin was expressed as histidine-tag protein in E. coli and purified by histidine-tag affinity column.	Histidine	51-60	cilia and flagella associated protein 97	Homo sapiens	21-24
27191381-3	2016	Compared with the self-assembled catalytic nanofibers (SA-H), which contain only the catalytic histidine residue, the highest activity of CoA-HSD occurs when histidine, serine, and aspartate residues are at a ratio of 40:1:1.	Histidine	95-104	acyl-CoA synthetase medium chain family member 3	Homo sapiens	55-59
22621930-7	2012	An analysis of homology models docked with UDP-sugar donors indicates that Asn-391 in UGT3A1 is able to accommodate the N-acetyl group on C2 of UDP-GlcNAc so that the anomeric carbon atom (C1) is optimally situated for catalysis involving His-35.	Histidine	239-242	UDP glycosyltransferase family 3 member A1	Homo sapiens	86-92
22452398-8	2012	Mutation analysis of the CYP17A1 gene identified a homozygous missense mutation changing His (CAC) to Leu (CTC) at codon 373.	Histidine	89-92	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	25-32
27191381-3	2016	Compared with the self-assembled catalytic nanofibers (SA-H), which contain only the catalytic histidine residue, the highest activity of CoA-HSD occurs when histidine, serine, and aspartate residues are at a ratio of 40:1:1.	Histidine	158-167	acyl-CoA synthetase medium chain family member 3	Homo sapiens	55-59
26769972-6	2016	Comparison between the high-resolution SFX and SRX data revealed the subtle structural change of a catalytic His residue by X-ray photoreduction.	Histidine	109-112	sulfiredoxin 1	Homo sapiens	47-50
22713565-4	2012	Here, we find H2O2-enhanced oligomerization of KCNQ4 subunits, as reported by nondenaturing polyacrylamide gel electrophoresis, at C643 at the end of the D-helix, where KCNQ3 possesses a histidine.	Histidine	187-196	potassium voltage-gated channel subfamily Q member 4	Homo sapiens	47-52
22713565-4	2012	Here, we find H2O2-enhanced oligomerization of KCNQ4 subunits, as reported by nondenaturing polyacrylamide gel electrophoresis, at C643 at the end of the D-helix, where KCNQ3 possesses a histidine.	Histidine	187-196	potassium voltage-gated channel subfamily Q member 3	Homo sapiens	169-174
26875527-10	2016	Of importance, the intranasal delivery of miR-210-LNA 4h after the HI insult produced similar effects in decreasing HI-induced neonatal brain injury and improving neurological function later in life.	Histidine	67-69	microRNA 210	Rattus norvegicus	42-49
22437839-3	2012	These enzymes share high sequence identity and catalyze 4-pro-(R)-hydride transfer from NADPH to an electrophilic carbon but differ in that one residue in the conserved AKR catalytic tetrad, His(120) (AKR1D1 numbering), is substituted by a glutamate in AKR1D1.	Histidine	191-194	aldo-keto reductase family 1 member D1	Homo sapiens	201-207
22437839-3	2012	These enzymes share high sequence identity and catalyze 4-pro-(R)-hydride transfer from NADPH to an electrophilic carbon but differ in that one residue in the conserved AKR catalytic tetrad, His(120) (AKR1D1 numbering), is substituted by a glutamate in AKR1D1.	Histidine	191-194	aldo-keto reductase family 1 member D1	Homo sapiens	253-259
23961177-10	2012	However, Met, Ile, Phe and His were significantly higher for beta-casein of Majaheim compared to the other two milk breeds.	Histidine	27-30	beta-casein	Camelus bactrianus	61-72
26854536-4	2016	One inhibitor pole locates in the phospholipid headgroup binding site and the second solvent-exposed ring binds to the His-Tag of another INPP5B molecule, while a molecule of inorganic phosphate is also present in the active site.	Histidine	119-122	inositol polyphosphate-5-phosphatase B	Homo sapiens	138-144
22185821-5	2012	Cyclooxygenase-2 and matrix metalloproteinase 3, two gene products governed by NF-kappaB, were down-regulated by cyclo(His-Pro) and up-regulated in heme oxygenase-1 knock-down cells.	Histidine	119-122	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	0-47
26829225-5	2016	Snu114 harbours GTP, but its putative catalytic histidine is held away from the gamma-phosphate by hydrogen bonding to a tyrosine in the amino-terminal domain of Prp8.	Histidine	48-57	U5 snRNP GTPase SNU114	Saccharomyces cerevisiae S288C	0-6
22034099-8	2012	In an analysis involving recombinant His-DDX3 and His-DDX5, PP2A pretreatment of His-DDX5 increased the interaction with endogenous DDX3, and vice versa.	Histidine	37-40	DEAD-box helicase 3 X-linked	Homo sapiens	41-45
22034099-8	2012	In an analysis involving recombinant His-DDX3 and His-DDX5, PP2A pretreatment of His-DDX5 increased the interaction with endogenous DDX3, and vice versa.	Histidine	37-40	DEAD-box helicase 3 X-linked	Homo sapiens	132-136
22034099-8	2012	In an analysis involving recombinant His-DDX3 and His-DDX5, PP2A pretreatment of His-DDX5 increased the interaction with endogenous DDX3, and vice versa.	Histidine	50-53	DEAD-box helicase 3 X-linked	Homo sapiens	132-136
22034099-8	2012	In an analysis involving recombinant His-DDX3 and His-DDX5, PP2A pretreatment of His-DDX5 increased the interaction with endogenous DDX3, and vice versa.	Histidine	50-53	DEAD-box helicase 3 X-linked	Homo sapiens	132-136
26829225-5	2016	Snu114 harbours GTP, but its putative catalytic histidine is held away from the gamma-phosphate by hydrogen bonding to a tyrosine in the amino-terminal domain of Prp8.	Histidine	48-57	U4/U6-U5 snRNP complex subunit PRP8	Saccharomyces cerevisiae S288C	162-166
26707622-11	2016	Immunoblotting indicated that maltose-binding protein (MBP)-OGT inhibited the binding of His-p120 to GST-ECD in a dose-dependent manner.	Histidine	89-92	myelin basic protein	Homo sapiens	30-53
22259020-4	2012	These studies showed that aspartate-8, histidine-11, glycine-6, proline-4, arginine-1, and proline-9, arranged in an order of importance, were critical, while threonine-2, valine-3, serine-5, and the previously assigned hydroxylation and arabinosylation residue proline-7 were trivial for the endogenous CLV3 function in SAM maintenance.	Histidine	39-48	CLAVATA3	Arabidopsis thaliana	304-308
26707622-11	2016	Immunoblotting indicated that maltose-binding protein (MBP)-OGT inhibited the binding of His-p120 to GST-ECD in a dose-dependent manner.	Histidine	89-92	myelin basic protein	Homo sapiens	55-58
26707622-11	2016	Immunoblotting indicated that maltose-binding protein (MBP)-OGT inhibited the binding of His-p120 to GST-ECD in a dose-dependent manner.	Histidine	89-92	catenin delta 1	Homo sapiens	93-97
26657863-6	2016	Progesterone receptor membrane component-1 (PGRMC1) was required for HIS-dependent increases in hepcidin biosynthesis, as PGRMC1 depletion in cultured hepatoma cells and zebrafish blocked the ability of HISs to increase hepcidin mRNA levels.	Histidine	69-72	progesterone receptor membrane component 1	Danio rerio	122-128
22133715-6	2012	The CCT1 subunit was engineered to carry a hexa-histidine tag or FLAG tag in the internal loop region.	Histidine	48-57	t-complex 1	Homo sapiens	4-8
26606132-6	2016	The ability of Ser(F7) and His(FG3) in Mb to form stabilizing contacts with the heme-7-propionate maintains hemin within the globin whereas Leu(F7) and Leu(FG3) of Hb cannot form stabilizing contacts which results in low hemin affinity.	Histidine	27-30	myoglobin	Bos taurus	39-41
22083354-9	2012	The missense mutation of the conserved histidine residue of the lx2 allele was developed into a single nucleotide-amplified polymorphism (SNAP) marker.	Histidine	39-48	seed linoleate 9S-lipoxygenase-2	Glycine max	64-67
22178916-5	2012	SPR measurements also proved the conjugation of His-AP with the NTA-modified DNA via an Ni2+ complex.	Histidine	48-51	sepiapterin reductase	Homo sapiens	0-3
16607940-2	2006	In this paper, hBNP was expressed as a fusion protein with a histidine tag and Ssp dnaB mini-intein which was capable of self-cleavage.	Histidine	61-70	natriuretic peptide B	Homo sapiens	15-19
26310108-1	2015	In this investigation, chitosan-histidine-cysteine (CHC) was engineered for oral delivery of Survivin short hairpin RNA (shRNA)-expressing plasmid DNA (shSur-pDNA) to promote hepatoma regression through integrating the advantages of histidine and cysteine to conquer serial cellular and systemic barriers.	Histidine	32-41	baculoviral IAP repeat-containing 5	Mus musculus	93-101
16828466-5	2006	Moving in vivo, we demonstrated that subcutaneously administered his(6)CTLA-4.FasL modulates the in vivo response of infused allogeneic splenocytes.	Histidine	65-68	Fas ligand (TNF superfamily, member 6)	Mus musculus	78-82
26310108-3	2015	Sequential modification with histidine and cysteine conferred CHC NC with the beneficial attributes for shRNA delivery including improved stability, facilitated internalization, promoted endosomal escape, increased nuclear localization, and GSH-responsive release, which contributed to their superior performance in terms of apoptosis promotion, proliferation inhibition, and Survivin down-regulation of tumor cells.	Histidine	29-38	baculoviral IAP repeat-containing 5	Mus musculus	376-384
21310790-7	2012	Moreover, mutation of a conserved histidine in the NACHT domain also has contrasting effects on NOD1 and NOD2 mediated NF-kappaB activation.	Histidine	34-43	nucleotide binding oligomerization domain containing 2	Homo sapiens	105-109
26445170-2	2015	Mutation of the tryptophan in the WPD loop of the PTP YopH to any other residue with a planar, aromatic side chain (phenylalanine, tyrosine, or histidine) disables general acid catalysis.	Histidine	144-153	protein tyrosine phosphatase receptor type U	Homo sapiens	50-53
16862454-2	2006	The changes in the distance between N(epsilon2) of His(12) and N(delta1) of His(119) at the catalytic center of RNase A upon the addition of sodium sulfate, sodium hydrogen sulfate and sodium thiocyanate were evaluated by molecular dynamic methods.	Histidine	51-54	ribonuclease A family member 1, pancreatic	Homo sapiens	112-119
16862454-2	2006	The changes in the distance between N(epsilon2) of His(12) and N(delta1) of His(119) at the catalytic center of RNase A upon the addition of sodium sulfate, sodium hydrogen sulfate and sodium thiocyanate were evaluated by molecular dynamic methods.	Histidine	76-79	ribonuclease A family member 1, pancreatic	Homo sapiens	112-119
26335560-3	2015	The results showed that CPN caused a small increase in the number of histidine revertant colonies in S. typhimurium strains TA98 and TA100, but not statistically significant (p &gt; 0.05).	Histidine	69-78	carboxypeptidase N, polypeptide 1	Mus musculus	24-27
16584607-5	2006	While there is a translation-enhancing sequence T7-g10 in the PRSETA-B7-2-PE40KDEL expression vector, so it adds 6 histidines to the N terminus of the protein of interest, this allows to purify the protein of interest by metal chelating chromatography.	Histidine	115-125	CD86 molecule	Homo sapiens	69-73
20810007-7	2012	B. arenarum oviductin is a multi-domain protein with a protease domain at the N-terminal region followed by two CUB domains and toward the C-terminal region another protease domain, which lacked an active histidine site, and one CUB domain.	Histidine	205-214	oviductal glycoprotein 1	Homo sapiens	12-21
22033154-7	2012	The system enabled us to monitor in real-time the selective extraction of two histidine-tagged proteins, PIGEA14 (14 kDa) and ezrin (70 kDa), directly from cell lysate solutions using a DOGS-NTA(Ni)/DOPC (1:9) membrane.	Histidine	78-87	ezrin	Canis lupus familiaris	126-131
26323297-3	2015	In this study, the short form of the coiled-coil domain of SYCP1 was overexpressed in Escherichia coli with an engineered C-terminal His tag.	Histidine	133-136	synaptonemal complex protein 1	Homo sapiens	59-64
23189152-0	2012	The peripheral binding of 14-3-3gamma to membranes involves isoform-specific histidine residues.	Histidine	77-86	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma	Homo sapiens	26-37
16388582-0	2006	Structural changes of phenylalanine 338 and histidine 447 revealed by the crystal structures of tabun-inhibited murine acetylcholinesterase.	Histidine	44-53	acetylcholinesterase	Mus musculus	119-139
26226559-0	2015	Allosteric Breakage of the Hydrogen Bond within the Dual-Histidine Motif in the Active Site of Human Pin1 PPIase.	Histidine	57-66	peptidylprolyl isomerase like 3	Homo sapiens	106-112
21204476-14	2006	Erf2p and Akr1p are integral membrane proteins harboring a cysteine-rich domain containing a conserved DHHC (Asp-His-His-Cys) motif.	Histidine	113-116	palmitoyltransferase AKR1	Saccharomyces cerevisiae S288C	10-15
22139181-2	2011	In this work, two types of recombinant HP0902 protein were crystallized: one with an N-terminal His(6) tag ((H6)HP0902) and the other with a C-terminal His(6) tag (HP0902(H6)).	Histidine	96-99	cupin domain-containing protein	Helicobacter pylori 26695	39-45
22139181-2	2011	In this work, two types of recombinant HP0902 protein were crystallized: one with an N-terminal His(6) tag ((H6)HP0902) and the other with a C-terminal His(6) tag (HP0902(H6)).	Histidine	152-155	cupin domain-containing protein	Helicobacter pylori 26695	39-45
26110992-0	2015	Determination of Histidine pKa Values in the Propeptides of Furin and Proprotein Convertase 1/3 Using Histidine Hydrogen-Deuterium Exchange Mass Spectrometry.	Histidine	17-26	furin, paired basic amino acid cleaving enzyme	Homo sapiens	60-65
21750908-1	2011	Mutation of galectin-3 at position 191 (rs4644) substituting proline to histidine (gal-3H(64)) resulted in the acquisition of resistance to drug-induced apoptosis by breast cancer cells.	Histidine	72-81	galectin 3	Homo sapiens	12-22
21939771-8	2011	CsCatL has an N-terminal cathepsin propeptide inhibitor domain followed by a Papain family cysteine protease domain, the latter containing four conserved catalytic residues: Gln-133, Cys-139, His-279, and Asn-303.	Histidine	192-195	cathepsin L	Cynoglossus semilaevis	0-6
16328055-2	2006	Histidine decarboxylase (HDC) catalyzes the formation of histamine from histidine.	Histidine	72-81	histidine decarboxylase	Homo sapiens	0-23
16328055-2	2006	Histidine decarboxylase (HDC) catalyzes the formation of histamine from histidine.	Histidine	72-81	histidine decarboxylase	Homo sapiens	25-28
26110992-0	2015	Determination of Histidine pKa Values in the Propeptides of Furin and Proprotein Convertase 1/3 Using Histidine Hydrogen-Deuterium Exchange Mass Spectrometry.	Histidine	102-111	furin, paired basic amino acid cleaving enzyme	Homo sapiens	60-65
21703367-3	2011	It is shown that protonation of the pyridine ring of PLP in aspartate aminotransferase (AspAT) is achieved by (i) an intermolecular OHN hydrogen bond with an aspartate residue, assisted by the imidazole group of a histidine side chain and (ii) a local polarity as found for related model systems in a polar organic solvent exhibiting a dielectric constant of about 30.	Histidine	214-223	pyridoxal phosphatase	Homo sapiens	53-56
26110992-2	2015	Earlier experimental work highlighted the importance of a conserved histidine residue within the propeptide of a widely studied member, furin.	Histidine	68-77	furin, paired basic amino acid cleaving enzyme	Homo sapiens	136-141
16314460-6	2005	Thus, in U4 atac snRNA we identified His 270 in the spliceosomal U4/U6 snRNP-specific protein 61 K (hPrp31p) cross-linked to U 44; in the U1 snRNP we show that Leu175 of the U1 snRNP-specific 70K protein is cross-linked to U 30 of U1 snRNA.	Histidine	37-40	RNA, U1 small nuclear 1	Homo sapiens	138-146
26110992-6	2015	In this manuscript, we measured the pKa values of histidines within the propeptides of furin and proprotein convertase 1/3 using a histidine hydrogen-deuterium exchange mass spectrometry approach.	Histidine	50-60	furin, paired basic amino acid cleaving enzyme	Homo sapiens	87-92
16168961-3	2005	HOXA1 contains a string of 10 histidine repeats.	Histidine	30-39	homeobox A1	Homo sapiens	0-5
26110992-6	2015	In this manuscript, we measured the pKa values of histidines within the propeptides of furin and proprotein convertase 1/3 using a histidine hydrogen-deuterium exchange mass spectrometry approach.	Histidine	50-59	furin, paired basic amino acid cleaving enzyme	Homo sapiens	87-92
26110992-9	2015	Finally, we demonstrate that the pKa of the conserved histidine in proprotein convertase 1/3 is acid-shifted compared with furin and is consistent with its lower pH of activation.	Histidine	54-63	furin, paired basic amino acid cleaving enzyme	Homo sapiens	123-128
26190207-3	2015	We found that, unlike previous report, Arg 100 contributes less to PP5-inhibitor binding, and the residues His 69, Asn 128, His 129, Arg 225, His 252 and Arg 250 are of importance to PP5-inhibitor binding.	Histidine	107-110	protein phosphatase 5 catalytic subunit	Homo sapiens	183-186
16040738-5	2005	These experiments reveal that, in ferric SOLly GLB1, one of the histidine planes is rotated 20 degrees (+/-10 degrees ) away from a N(heme)-Fe-N(heme) axis.	Histidine	64-73	non-symbiotic hemoglobin class 1	Solanum lycopersicum	47-51
22977637-6	2011	The risk of prostate cancer in individuals carrying the SULT1A1(*)2 allele (His(213) allele) was determined by combining the SULT1A1(*)1/SULT1A1(*)2 (Arg/His(213)) and SULT1A1(*)2/SULT1A1(*)2 (His/His(213)) genotypes.	Histidine	76-79	sulfotransferase family 1A member 1	Homo sapiens	56-63
22977637-6	2011	The risk of prostate cancer in individuals carrying the SULT1A1(*)2 allele (His(213) allele) was determined by combining the SULT1A1(*)1/SULT1A1(*)2 (Arg/His(213)) and SULT1A1(*)2/SULT1A1(*)2 (His/His(213)) genotypes.	Histidine	76-79	sulfotransferase family 1A member 1	Homo sapiens	125-132
26190207-3	2015	We found that, unlike previous report, Arg 100 contributes less to PP5-inhibitor binding, and the residues His 69, Asn 128, His 129, Arg 225, His 252 and Arg 250 are of importance to PP5-inhibitor binding.	Histidine	124-127	protein phosphatase 5 catalytic subunit	Homo sapiens	183-186
22977637-6	2011	The risk of prostate cancer in individuals carrying the SULT1A1(*)2 allele (His(213) allele) was determined by combining the SULT1A1(*)1/SULT1A1(*)2 (Arg/His(213)) and SULT1A1(*)2/SULT1A1(*)2 (His/His(213)) genotypes.	Histidine	76-79	sulfotransferase family 1A member 1	Homo sapiens	125-132
22977637-6	2011	The risk of prostate cancer in individuals carrying the SULT1A1(*)2 allele (His(213) allele) was determined by combining the SULT1A1(*)1/SULT1A1(*)2 (Arg/His(213)) and SULT1A1(*)2/SULT1A1(*)2 (His/His(213)) genotypes.	Histidine	76-79	sulfotransferase family 1A member 1	Homo sapiens	125-132
26190207-3	2015	We found that, unlike previous report, Arg 100 contributes less to PP5-inhibitor binding, and the residues His 69, Asn 128, His 129, Arg 225, His 252 and Arg 250 are of importance to PP5-inhibitor binding.	Histidine	124-127	protein phosphatase 5 catalytic subunit	Homo sapiens	183-186
22977637-6	2011	The risk of prostate cancer in individuals carrying the SULT1A1(*)2 allele (His(213) allele) was determined by combining the SULT1A1(*)1/SULT1A1(*)2 (Arg/His(213)) and SULT1A1(*)2/SULT1A1(*)2 (His/His(213)) genotypes.	Histidine	76-79	sulfotransferase family 1A member 1	Homo sapiens	125-132
22977637-6	2011	The risk of prostate cancer in individuals carrying the SULT1A1(*)2 allele (His(213) allele) was determined by combining the SULT1A1(*)1/SULT1A1(*)2 (Arg/His(213)) and SULT1A1(*)2/SULT1A1(*)2 (His/His(213)) genotypes.	Histidine	154-157	sulfotransferase family 1A member 1	Homo sapiens	56-63
25937317-3	2015	Proteins enriched in lysine and other positively charged residues (histidine and arginine) as well as glycosaminoglycans and gangliosides bind Plg.	Histidine	67-76	plasminogen	Homo sapiens	143-146
21821028-3	2011	Point mutations were then introduced, and residues Cys-56, Tyr-77, His-79, and Tyr-90 were essential for the EYA3s threonine-phosphatase.	Histidine	67-70	EYA transcriptional coactivator and phosphatase 3	Mus musculus	109-113
16237777-1	2005	AIM: To investigate the expression of fragile histidine triad (FHIT) protein, and the possible relationship between FHIT expression and clinicopathological indices in gastric carcinoma.	Histidine	46-55	fragile histidine triad diadenosine triphosphatase	Homo sapiens	63-67
16142915-9	2005	We use this continuous assay to analyze catalysis by wild-type human PDI and a variant in which the C-terminal cysteine residue within each Cys-Gly-His-Cys active site is replaced with alanine.	Histidine	148-151	prolyl 4-hydroxylase subunit beta	Homo sapiens	69-72
25990001-0	2015	Contribution of two conserved histidines to the dual activity of archaeal RNA guide-dependent and -independent pseudouridine synthase Cbf5.	Histidine	30-40	dyskerin pseudouridine synthase 1	Homo sapiens	134-138
15994298-0	2005	Identification of a crucial histidine involved in metal transport activity in the Arabidopsis cation/H+ exchanger CAX1.	Histidine	28-37	cation exchanger 1	Arabidopsis thaliana	114-118
15994298-3	2005	We have used site-directed mutagenesis to assess the impact of altering the seven histidine residues to alanine within Arabidopsis CAX1.	Histidine	82-91	cation exchanger 1	Arabidopsis thaliana	131-135
21730068-4	2011	Detailed analysis, including a comparison of the tertiary structure of Pos5 with the structures of human and bacterial NAD kinases, revealed that Arg-293 of Pos5, corresponding to His-351 of human NAD kinase, confers a positive charge on the surface of NADH-binding site, whereas the corresponding His residue does not.	Histidine	180-183	NADH kinase	Saccharomyces cerevisiae S288C	71-75
21730068-4	2011	Detailed analysis, including a comparison of the tertiary structure of Pos5 with the structures of human and bacterial NAD kinases, revealed that Arg-293 of Pos5, corresponding to His-351 of human NAD kinase, confers a positive charge on the surface of NADH-binding site, whereas the corresponding His residue does not.	Histidine	180-183	NADH kinase	Saccharomyces cerevisiae S288C	157-161
21730068-4	2011	Detailed analysis, including a comparison of the tertiary structure of Pos5 with the structures of human and bacterial NAD kinases, revealed that Arg-293 of Pos5, corresponding to His-351 of human NAD kinase, confers a positive charge on the surface of NADH-binding site, whereas the corresponding His residue does not.	Histidine	298-301	NADH kinase	Saccharomyces cerevisiae S288C	71-75
21730068-4	2011	Detailed analysis, including a comparison of the tertiary structure of Pos5 with the structures of human and bacterial NAD kinases, revealed that Arg-293 of Pos5, corresponding to His-351 of human NAD kinase, confers a positive charge on the surface of NADH-binding site, whereas the corresponding His residue does not.	Histidine	298-301	NADH kinase	Saccharomyces cerevisiae S288C	157-161
25560907-0	2015	protonation behavior of histidine during HSF1 activation by physiological acidification.	Histidine	24-33	heat shock transcription factor 1	Homo sapiens	41-45
21730068-6	2011	Conversely, simultaneous changes of Ala-330 and His-351 of human NAD kinase into Ser and Arg residues significantly increased the ratio of NADH kinase activity to NAD kinase activity from 0.043 to 1.39; human Ala-330 corresponds to Pos5 Ser-272, which interacts with the side chain of Arg-293.	Histidine	48-51	NADH kinase	Saccharomyces cerevisiae S288C	232-236
15951563-8	2005	The bromo domain and cysteine- and histidine-rich domains of p300 were required for repression by cyclin D1.	Histidine	35-44	E1A binding protein p300	Homo sapiens	61-65
15951563-8	2005	The bromo domain and cysteine- and histidine-rich domains of p300 were required for repression by cyclin D1.	Histidine	35-44	cyclin D1	Homo sapiens	98-107
15967801-1	2005	The human gonadotropin-releasing hormone (GnRH) receptor is evolutionarily configured for high affinity binding of GnRH I ([Tyr(5),Leu(7),Arg(8)]GnRH) but at lower affinity for GnRH II ([His(5),Trp(7),Tyr(8)]GnRH).	Histidine	187-190	gonadotropin releasing hormone receptor	Homo sapiens	10-56
15967801-1	2005	The human gonadotropin-releasing hormone (GnRH) receptor is evolutionarily configured for high affinity binding of GnRH I ([Tyr(5),Leu(7),Arg(8)]GnRH) but at lower affinity for GnRH II ([His(5),Trp(7),Tyr(8)]GnRH).	Histidine	187-190	gonadotropin releasing hormone 1	Homo sapiens	42-46
21825130-0	2011	Iroquois homeobox gene 3 establishes fast conduction in the cardiac His-Purkinje network.	Histidine	68-71	iroquois homeobox 3	Homo sapiens	0-24
15967801-1	2005	The human gonadotropin-releasing hormone (GnRH) receptor is evolutionarily configured for high affinity binding of GnRH I ([Tyr(5),Leu(7),Arg(8)]GnRH) but at lower affinity for GnRH II ([His(5),Trp(7),Tyr(8)]GnRH).	Histidine	187-190	gonadotropin releasing hormone 1	Homo sapiens	115-119
25560907-6	2015	The histidine 83 (His83) residue, which could be protonated by mild decrease in pH, causes mild acidic-induced HSF1 activation (including in-vitro trimerization, DNA binding, in-vivo nuclear accumulation, and HSPs expression).	Histidine	4-13	heat shock transcription factor 1	Homo sapiens	111-115
15967801-1	2005	The human gonadotropin-releasing hormone (GnRH) receptor is evolutionarily configured for high affinity binding of GnRH I ([Tyr(5),Leu(7),Arg(8)]GnRH) but at lower affinity for GnRH II ([His(5),Trp(7),Tyr(8)]GnRH).	Histidine	187-190	gonadotropin releasing hormone 1	Homo sapiens	115-119
25560907-8	2015	Therefore, low-pH-induced activation of HSF1 by the protonation of histidine can help us better to understand the HSF1 mechanism and develop more therapeutic applications (particularly in cancer therapy).	Histidine	67-76	heat shock transcription factor 1	Homo sapiens	40-44
25560907-8	2015	Therefore, low-pH-induced activation of HSF1 by the protonation of histidine can help us better to understand the HSF1 mechanism and develop more therapeutic applications (particularly in cancer therapy).	Histidine	67-76	heat shock transcription factor 1	Homo sapiens	114-118
15951442-8	2005	Therefore, the conserved histidines and Glu405 are absolutely required for the catalytic mechanism of BCMO1.	Histidine	25-35	beta-carotene oxygenase 1	Mus musculus	102-107
26055918-0	2015	Leucine and histidine independently regulate milk protein synthesis in bovine mammary epithelial cells via mTOR signaling pathway.	Histidine	12-21	mechanistic target of rapamycin kinase	Bos taurus	107-111
26055918-7	2015	In conclusion, the milk protein synthesis was up-regulated through activation of the mTOR pathway with the addition of Leu and His in CMEC-H.	Histidine	127-130	mechanistic target of rapamycin kinase	Bos taurus	85-89
25936509-4	2015	HMT activity after reserpine, pargyline and L-histidine treatment showed no differences compared to the control values.	Histidine	44-55	histamine N-methyltransferase	Rattus norvegicus	0-3
16027075-1	2005	OBJECTIVE: To detect the expressions of fragile histidine triad (FHIT) and cyclin D1/CDK4 in oral squamous cell carcinoma (OSCC) and oral precancerous lesions and investigate the relationship between the expressions and the histopathological changes.	Histidine	48-57	fragile histidine triad diadenosine triphosphatase	Homo sapiens	65-69
21402045-5	2011	The presence of these vesicles in the reaction buffer enhanced the specific activity of the His-tagged PDK1 (full-length, and the truncated kinase domain) and the activity of the full-length His-tagged AKT1 and AKT2 when assayed in a cascade-type reaction.	Histidine	191-194	RAC-alpha serine/threonine-protein kinase	Cricetulus griseus	202-206
24998847-1	2015	Fragile histidine triad (FHIT) loss by the two-hit mechanism of loss of heterozygosity and promoter hypermethylation commonly occurrs in non-small cell lung cancer (NSCLC) and may confer cisplatin resistance in NSCLC cells.	Histidine	8-17	fragile histidine triad diadenosine triphosphatase	Homo sapiens	25-29
21568282-3	2011	Using a combinatorial histidine-scanning phage display library, potential metal binding sites were introduced throughout an anti-RNase A antibody interface.	Histidine	22-31	ribonuclease A family member 1, pancreatic	Homo sapiens	129-136
21711110-3	2011	Fragile histidine triad (FHIT) gene deletion, methylation, and reduced Fhit protein expression occur in about 70% of human epithelial tumors and are clearly associated with tumor progression.	Histidine	8-17	fragile histidine triad diadenosine triphosphatase	Homo sapiens	25-29
15942648-2	2005	We previously isolated a mouse orthologue of HAUSP, mHAUSP, encoding 1103 amino acids with a molecular weight of approximately 135 kDa containing highly conserved Cys, Asp (I), His, and Asn/Asp (II) domains.	Histidine	177-180	ubiquitin specific peptidase 7	Mus musculus	45-50
15942648-2	2005	We previously isolated a mouse orthologue of HAUSP, mHAUSP, encoding 1103 amino acids with a molecular weight of approximately 135 kDa containing highly conserved Cys, Asp (I), His, and Asn/Asp (II) domains.	Histidine	177-180	ubiquitin specific peptidase 7	Mus musculus	52-58
16013617-4	2005	In this paper, we present the isolation of a his-tagged lac repressor, its non-covalent immobilisation to different matrices and binding of DNA, thus enabling us to screen for combinations of ligands and stationary phases by using a building block principle.	Histidine	4-7	lactase	Homo sapiens	56-59
25811613-2	2015	Here, a micellar system employing TfR-specific 7peptide (histidine-alanine-isoleucine-tyrosine- proline-arginine-histidine, HAIYPRH, 7pep) as the targeting moiety was constructed; and its endocytosis, intracellular trafficking as well as influence on TfR expression and in vivo tumor targeting were explored in the MCF-7 tumor model.	Histidine	57-66	transferrin receptor	Homo sapiens	34-37
15924435-7	2005	In a direct test of the model, we compared Sst2 phosphorylation following systematic substitution of the -1 residue His-538.	Histidine	116-119	GTPase-activating protein SST2	Saccharomyces cerevisiae S288C	43-47
21440039-2	2011	Histidine decarboxylase (HDC) synthesizes histamine from histidine; in the brain, its mRNA is expressed exclusively in the posterior hypothalamus.	Histidine	57-66	histidine decarboxylase	Mus musculus	0-23
21440039-2	2011	Histidine decarboxylase (HDC) synthesizes histamine from histidine; in the brain, its mRNA is expressed exclusively in the posterior hypothalamus.	Histidine	57-66	histidine decarboxylase	Mus musculus	25-28
15929169-1	2005	AIM: To examine the aberrant expression of fragile histidine triad (FHIT) gene and protein in gastric cancer, and to evaluate the role of FHIT gene and the relationship between FHIT gene and EBV infection in gastric carcinogenesis.	Histidine	51-60	fragile histidine triad diadenosine triphosphatase	Homo sapiens	68-72
25596185-5	2015	hETHE1 contains an alphabetabetaalpha MBL-fold, which supports metal-binding by the side chains of an aspartate and two histidine residues; three water molecules complete octahedral coordination of the iron.	Histidine	120-129	ETHE1 persulfide dioxygenase	Homo sapiens	0-6
15731110-6	2005	Mutation of a single Glu residue in the S3-S4 linker and a His residue in the pore region each reduced sensitivity of TRPM5 currents to fast acid block (IC(50) pH = 5.8 for both), and the double mutant was nearly insensitive to acidic pH (IC(50) pH = 5.0).	Histidine	59-62	transient receptor potential cation channel subfamily M member 5	Homo sapiens	118-123
20957682-0	2011	Effect of histidine on autotaxin activity in experimentally induced liver fibrosis.	Histidine	10-19	ectonucleotide pyrophosphatase/phosphodiesterase 2	Rattus norvegicus	23-32
20957682-5	2011	Upon treatment with histidine, a significant decrease in liver enzymes, ATX activities, and liver hydroxyproline was observed with a significant increase in plasma TAC in Group IV and a significant decrease in Group V. Histidine as an antioxidant has a protective effect on TAA-induced liver fibrosis; it is beneficial in rats not only by inhibition of collagen synthesis and increasing TAC but also by inhibition of ATX activities thus reducing its capacity to produce lysophosphatidic acid, which has a role in liver fibrosis.	Histidine	20-29	ectonucleotide pyrophosphatase/phosphodiesterase 2	Rattus norvegicus	72-75
20957682-5	2011	Upon treatment with histidine, a significant decrease in liver enzymes, ATX activities, and liver hydroxyproline was observed with a significant increase in plasma TAC in Group IV and a significant decrease in Group V. Histidine as an antioxidant has a protective effect on TAA-induced liver fibrosis; it is beneficial in rats not only by inhibition of collagen synthesis and increasing TAC but also by inhibition of ATX activities thus reducing its capacity to produce lysophosphatidic acid, which has a role in liver fibrosis.	Histidine	20-29	ectonucleotide pyrophosphatase/phosphodiesterase 2	Rattus norvegicus	417-420
25596185-7	2015	The histidine and aspartate residues involved in iron-binding in ETHE1, occupy similar positions to those observed across both the zinc 1 and zinc 2 binding sites in classical MBLs.	Histidine	4-13	ETHE1 persulfide dioxygenase	Homo sapiens	65-70
25720604-2	2015	A pre-defined stem-loop library, containing LNA in the forward primer region, was enriched with CD73 binding sequences through six rounds of SELEX with recombinant his-tagged CD73 immobilised on anti-his plates.	Histidine	164-167	5'-nucleotidase ecto	Homo sapiens	175-179
21243331-4	2011	Comparisons of the sequences for lipoxygenase 1 (Lx1) and lipoxygenase 2 (Lx2) genes in the mutant (OX948) with those in a line with normal lipoxygenase levels (RG10) showed that the mutations in these genes affected a highly conserved group of six histidines necessary for enzymatic activity.	Histidine	249-259	seed linoleate 9S-lipoxygenase-2	Glycine max	58-72
15788390-7	2005	The active site histidines, His-10 of IIA(Man) and His-15 (italics indicate HPr residues) of HPr, are in close proximity.	Histidine	28-31	haptoglobin-related protein	Homo sapiens	93-96
15788390-7	2005	The active site histidines, His-10 of IIA(Man) and His-15 (italics indicate HPr residues) of HPr, are in close proximity.	Histidine	51-54	haptoglobin-related protein	Homo sapiens	76-79
15788390-7	2005	The active site histidines, His-10 of IIA(Man) and His-15 (italics indicate HPr residues) of HPr, are in close proximity.	Histidine	51-54	haptoglobin-related protein	Homo sapiens	93-96
21243331-6	2011	A single T-A substitution in Lx2 changes histidine H532 (one of the iron-binding ligands essential for L-2 activity) to glutamine.	Histidine	41-50	seed linoleate 9S-lipoxygenase-2	Glycine max	29-32
25776553-4	2015	We identify five histidine residues in eEF2K that are crucial for the activation of eEF2K during acidosis.	Histidine	17-26	eukaryotic elongation factor 2 kinase	Homo sapiens	39-44
21243331-6	2011	A single T-A substitution in Lx2 changes histidine H532 (one of the iron-binding ligands essential for L-2 activity) to glutamine.	Histidine	41-50	seed linoleate 9S-lipoxygenase-2	Glycine max	103-106
21343298-8	2011	The E-loop of Nox4 but not Nox1 and Nox2 contains a highly conserved histidine that could serve as a source for protons to accelerate spontaneous dismutation of superoxide to form H(2)O(2).	Histidine	69-78	NADPH oxidase 4	Homo sapiens	14-18
21343298-9	2011	Mutation of this but not of four other conserved histidines also switched Nox4 from H(2)O(2) to O(2)( -) formation.	Histidine	49-59	NADPH oxidase 4	Homo sapiens	74-78
25776553-4	2015	We identify five histidine residues in eEF2K that are crucial for the activation of eEF2K during acidosis.	Histidine	17-26	eukaryotic elongation factor 2 kinase	Homo sapiens	84-89
25776553-6	2015	The other two histidines (H227 and H230) lie in the catalytic domain of eEF2K.	Histidine	14-24	eukaryotic elongation factor 2 kinase	Homo sapiens	72-77
25583361-8	2015	Results suggest that His(7.36(305)) of the GnRH receptor forms two distinct interactions that determine binding to Trp(3) and couple agonist binding to the conserved transmembrane domain network that activates GPCRs.	Histidine	21-24	gonadotropin releasing hormone 1	Homo sapiens	43-47
25643626-7	2015	Serine, proline, or histidine-mediated lifespan extension was greatly inhibited in eat-2 worms, a model of dietary restriction, in daf-16/FOXO, sir-2.1, rsks-1 (ribosomal S6 kinase), gcn-2, and aak-2 (AMPK) longevity pathway mutants, and in bec-1 autophagy-defective knockdown worms.	Histidine	20-29	Ribosomal protein S6 kinase beta	Caenorhabditis elegans	153-159
21424225-0	2011	Influence of v5/6-His tag on the properties of gap junction channels composed of connexin43, connexin40 or connexin45.	Histidine	18-21	gap junction protein alpha 1	Homo sapiens	81-91
25643626-7	2015	Serine, proline, or histidine-mediated lifespan extension was greatly inhibited in eat-2 worms, a model of dietary restriction, in daf-16/FOXO, sir-2.1, rsks-1 (ribosomal S6 kinase), gcn-2, and aak-2 (AMPK) longevity pathway mutants, and in bec-1 autophagy-defective knockdown worms.	Histidine	20-29	5'-AMP-activated protein kinase catalytic subunit alpha-2	Caenorhabditis elegans	194-199
25643626-7	2015	Serine, proline, or histidine-mediated lifespan extension was greatly inhibited in eat-2 worms, a model of dietary restriction, in daf-16/FOXO, sir-2.1, rsks-1 (ribosomal S6 kinase), gcn-2, and aak-2 (AMPK) longevity pathway mutants, and in bec-1 autophagy-defective knockdown worms.	Histidine	20-29	Beclin homolog	Caenorhabditis elegans	241-246
25554218-5	2015	ML-18 and EMY-98 inhibited specific (125)I-BA1 (DTyr-Gln-Trp-Ala-Val-betaAla-His-Phe-Nle-NH2)BB(6-14) binding to NCI-H1299 lung cancer cells stably transfected with BRS-3 with IC50 values of 4.8 and &gt;100muM, respectively.	Histidine	77-80	bombesin receptor subtype 3	Homo sapiens	165-170
21329668-2	2011	Using the recombinant extracellular region (coding for AA 22-258) of NKp46 tagged with 6x His (NKp46-H6), and mutants K136Q, R139Q, H142Q, R145Q, and K149Q, we determined their binding affinities to sulfate- and NeuAc-containing glycans-coated plates.	Histidine	90-93	natural cytotoxicity triggering receptor 1	Homo sapiens	69-74
25371203-1	2015	Thyrotropin-releasing hormone is a tripeptide that consists of 5-oxoproline, histidine, and proline.	Histidine	77-86	thyrotropin releasing hormone	Homo sapiens	0-29
21168482-9	2011	Co-expression of secretory forms of TNSALP (W) and TNSALP (A116T), which are engineered to replace the C-terminal GPI anchor with a tag sequence (his-tag or flag-tag), resulted in the release of heteromeric complexes consisting of TNSALP (W)-his and TNSALP (A116T)-flag.	Histidine	146-149	alkaline phosphatase, biomineralization associated	Homo sapiens	36-42
21168482-9	2011	Co-expression of secretory forms of TNSALP (W) and TNSALP (A116T), which are engineered to replace the C-terminal GPI anchor with a tag sequence (his-tag or flag-tag), resulted in the release of heteromeric complexes consisting of TNSALP (W)-his and TNSALP (A116T)-flag.	Histidine	146-149	alkaline phosphatase, biomineralization associated	Homo sapiens	51-57
21168482-9	2011	Co-expression of secretory forms of TNSALP (W) and TNSALP (A116T), which are engineered to replace the C-terminal GPI anchor with a tag sequence (his-tag or flag-tag), resulted in the release of heteromeric complexes consisting of TNSALP (W)-his and TNSALP (A116T)-flag.	Histidine	146-149	alkaline phosphatase, biomineralization associated	Homo sapiens	51-57
21168482-9	2011	Co-expression of secretory forms of TNSALP (W) and TNSALP (A116T), which are engineered to replace the C-terminal GPI anchor with a tag sequence (his-tag or flag-tag), resulted in the release of heteromeric complexes consisting of TNSALP (W)-his and TNSALP (A116T)-flag.	Histidine	146-149	alkaline phosphatase, biomineralization associated	Homo sapiens	51-57
21168482-9	2011	Co-expression of secretory forms of TNSALP (W) and TNSALP (A116T), which are engineered to replace the C-terminal GPI anchor with a tag sequence (his-tag or flag-tag), resulted in the release of heteromeric complexes consisting of TNSALP (W)-his and TNSALP (A116T)-flag.	Histidine	242-245	alkaline phosphatase, biomineralization associated	Homo sapiens	36-42
21168482-9	2011	Co-expression of secretory forms of TNSALP (W) and TNSALP (A116T), which are engineered to replace the C-terminal GPI anchor with a tag sequence (his-tag or flag-tag), resulted in the release of heteromeric complexes consisting of TNSALP (W)-his and TNSALP (A116T)-flag.	Histidine	242-245	alkaline phosphatase, biomineralization associated	Homo sapiens	51-57
21168482-9	2011	Co-expression of secretory forms of TNSALP (W) and TNSALP (A116T), which are engineered to replace the C-terminal GPI anchor with a tag sequence (his-tag or flag-tag), resulted in the release of heteromeric complexes consisting of TNSALP (W)-his and TNSALP (A116T)-flag.	Histidine	242-245	alkaline phosphatase, biomineralization associated	Homo sapiens	51-57
25608940-1	2015	We determined whether ring-2 carbon of histidine is folate-dependently transferred to carbons 8 (C8) and/or 2 (C2) in urinary uric acid in humans.	Histidine	39-48	ring finger protein 2	Homo sapiens	22-28
21168482-9	2011	Co-expression of secretory forms of TNSALP (W) and TNSALP (A116T), which are engineered to replace the C-terminal GPI anchor with a tag sequence (his-tag or flag-tag), resulted in the release of heteromeric complexes consisting of TNSALP (W)-his and TNSALP (A116T)-flag.	Histidine	242-245	alkaline phosphatase, biomineralization associated	Homo sapiens	51-57
25832641-0	2015	Analysis of cysteine and histidine residues required for zinc response of the transcription factor human MTF-1.	Histidine	25-34	metal regulatory transcription factor 1	Homo sapiens	105-110
21123168-4	2011	By means of site-directed mutagenesis and by UV-visible and EPR spectroscopy, we also show that the ferric heme of reduced (dithiol) Rev-erbbeta can undergo a redox-triggered switch from imidazole/thiol ligation (via His-568 and Cys-384, based on a prior crystal structure) to His/neutral residue ligation upon oxidation to the disulfide form.	Histidine	217-220	nuclear receptor subfamily 1 group D member 2	Homo sapiens	133-144
21123168-4	2011	By means of site-directed mutagenesis and by UV-visible and EPR spectroscopy, we also show that the ferric heme of reduced (dithiol) Rev-erbbeta can undergo a redox-triggered switch from imidazole/thiol ligation (via His-568 and Cys-384, based on a prior crystal structure) to His/neutral residue ligation upon oxidation to the disulfide form.	Histidine	277-280	nuclear receptor subfamily 1 group D member 2	Homo sapiens	133-144
25832641-3	2015	In the present study, Cys and His residues of human MTF-1 (hMTF-1), some of which may be involved in interaction with metals or with each other, were screened for their contribution to Zn-dependent transcription.	Histidine	30-33	metal regulatory transcription factor 1	Homo sapiens	52-57
21121676-4	2011	On the basis of a pH titration of LC elution buffers and MS/MS identification, recombinant NM23-H1 subjected to autophosphorylation was shown to contain phosphorylated histidine at residue 118 at pH 5 and 6, with each level giving over 75% peptide coverage for identification.	Histidine	168-177	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	91-98
25832641-3	2015	In the present study, Cys and His residues of human MTF-1 (hMTF-1), some of which may be involved in interaction with metals or with each other, were screened for their contribution to Zn-dependent transcription.	Histidine	30-33	metal regulatory transcription factor 1	Homo sapiens	59-65
26235586-6	2015	To produce and purify CMAH as simply as possible, we generated simian CMAH as a secretory protein with a histidine tag using a baculovirus protein expression system.	Histidine	105-114	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	70-74
21870644-2	2011	The present study aimed to identify and analyze the role of homozygous deletion (HZD) and transcriptional alterations of fragile histidine triad (FHIT) gene in the development and progression of bilharzial bladder cancer in Egyptian patients.	Histidine	129-138	fragile histidine triad diadenosine triphosphatase	Homo sapiens	146-150
25714963-7	2015	CONCLUSION: We found higher level of His in migraine patients without and with aura and lower level of Val and Leu in patients with migraine without aura.	Histidine	37-40	aurora kinase A	Homo sapiens	79-83
21941573-8	2011	Binding of a D5-derived peptide, HKH20 (His(479)-His(498)), to the fungal cell membrane was visualized by fluorescence microscopy.	Histidine	40-43	defensin alpha 24	Rattus norvegicus	13-15
21941573-8	2011	Binding of a D5-derived peptide, HKH20 (His(479)-His(498)), to the fungal cell membrane was visualized by fluorescence microscopy.	Histidine	49-52	defensin alpha 24	Rattus norvegicus	13-15
25492567-8	2015	Histamine is synthesized from l-histidine by histidine decarboxylase (HDC) in a single enzymatic step.	Histidine	30-41	histidine decarboxylase	Mus musculus	45-68
20589455-4	2011	ER-beta protein was immunologically detected as a 53 kDa his-tag protein in the pellet of the bacterial lysate.	Histidine	57-60	estrogen receptor 2 (beta)	Mus musculus	0-7
25492567-8	2015	Histamine is synthesized from l-histidine by histidine decarboxylase (HDC) in a single enzymatic step.	Histidine	30-41	histidine decarboxylase	Mus musculus	70-73
25617389-2	2015	The usefulness of the morpholinopropanesulfonic acid (MOPS)-histidine buffer in detecting beta2-transferrin, which is only found in the cerebrospinal fluid, was compared with the standard barbital buffer.	Histidine	60-69	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	90-95
25466186-1	2014	An asparagine or a histidine are present in a similar position in the outer pore region of SK2 and SK3 channels, respectively.	Histidine	19-28	sphingosine kinase 2	Homo sapiens	91-94
25538624-6	2014	UV/Vis spectroscopy, visible CD and catalase-like activity suggested that heme is accommodated inside His-tagged (tgA1M) and tagless A1M (ntA1M) in a rather similar fashion although the His-tag is very likely involved into coordination with iron of the heme molecule.	Histidine	102-105	alpha-1-microglobulin/bikunin precursor	Homo sapiens	116-119
21241597-0	2010	[Expression of fragile histidine triad (FHIT) protein and Ki-67 in transformed epithelial cells induced by Yunnan tin mine dust].	Histidine	23-32	fragile histidine triad diadenosine triphosphatase	Homo sapiens	40-44
21241597-1	2010	OBJECTIVE: To study the expression and significance of fragile histidine triad (FHIT) and Ki-67 in transformed epithelial cells induced by Yunnan tin mine dust.	Histidine	63-72	fragile histidine triad diadenosine triphosphatase	Homo sapiens	80-84
20958083-5	2010	Using nanografting, a tip-induced lithographic technique, and an affinity immobilization strategy based on two different histidine tagged antibodies, with high nM affinity for two different regions of PrP, we successfully demonstrated the immobilization of recombinant mouse PrP onto nanostructured surfaces, in two different orientations.	Histidine	121-130	prion protein	Mus musculus	201-204
21092292-7	2010	Alanine (Ala)-substitution of histidine (His) single amino acid repeats at 637,638 and/or 647,648 in Dvl3, like C-terminal deletion, abolishes Wnt 5a signal propagation.	Histidine	30-39	dishevelled segment polarity protein 3	Homo sapiens	101-105
21092292-7	2010	Alanine (Ala)-substitution of histidine (His) single amino acid repeats at 637,638 and/or 647,648 in Dvl3, like C-terminal deletion, abolishes Wnt 5a signal propagation.	Histidine	41-44	dishevelled segment polarity protein 3	Homo sapiens	101-105
21092292-7	2010	Alanine (Ala)-substitution of histidine (His) single amino acid repeats at 637,638 and/or 647,648 in Dvl3, like C-terminal deletion, abolishes Wnt 5a signal propagation.	Histidine	41-44	Wnt family member 3A	Homo sapiens	143-146
21092292-8	2010	Phenylalanine (Phe)-substitution of the same His-repeats in Dvl3 mimics Wnt5a stimulated NF-AT-sensitive transcription.	Histidine	45-48	dishevelled segment polarity protein 3	Homo sapiens	60-64
15897145-1	2005	OBJECTIVE: To detect the expression of fragile histidine triad (FHIT) in oral cancer and oral precancerous lesions and investigate the relationship between the FHIT expression and the histopathological changes.	Histidine	47-56	fragile histidine triad diadenosine triphosphatase	Homo sapiens	64-68
15767264-1	2005	In Arabidopsis thaliana, AUTHENTIC RESPONSE REGULATORS (ARRs) act as downstream components of the His-to-Asp phosphorelay (two-component) signaling pathway that is propagated primarily by the cytokinin receptor kinases, AUTHENTIC HIS-KINASES (AHK2, AHK3 and AHK4/CRE1).	Histidine	98-101	CHASE domain containing histidine kinase protein	Arabidopsis thaliana	258-262
15767264-1	2005	In Arabidopsis thaliana, AUTHENTIC RESPONSE REGULATORS (ARRs) act as downstream components of the His-to-Asp phosphorelay (two-component) signaling pathway that is propagated primarily by the cytokinin receptor kinases, AUTHENTIC HIS-KINASES (AHK2, AHK3 and AHK4/CRE1).	Histidine	98-101	CHASE domain containing histidine kinase protein	Arabidopsis thaliana	263-267
15949315-1	2005	OBJECTIVE: To investigate the inhibition effects of fragile histidine triad (FHIT) gene on the malignant growth of A549 cell line.	Histidine	60-69	fragile histidine triad diadenosine triphosphatase	Homo sapiens	77-81
15835917-1	2005	The human tumor suppressor Fhit is a homodimeric histidine triad (HIT) protein of 147 amino acids which has Ap(3)A hydrolase activity.	Histidine	49-58	fragile histidine triad diadenosine triphosphatase	Homo sapiens	27-31
15835917-1	2005	The human tumor suppressor Fhit is a homodimeric histidine triad (HIT) protein of 147 amino acids which has Ap(3)A hydrolase activity.	Histidine	49-58	fragile histidine triad diadenosine triphosphatase	Homo sapiens	108-124
15812576-6	2005	Direct rescue of the calcification phenotype was achieved by the administration of exogenous recombinant rat, histidine-fused OPN (rat His-OPN) to the implant site via soluble injection (up to 72% mitigation achieved) or adsorption onto the implant materials (up to 91% mitigation achieved).	Histidine	110-119	secreted phosphoprotein 1	Mus musculus	126-129
15812576-6	2005	Direct rescue of the calcification phenotype was achieved by the administration of exogenous recombinant rat, histidine-fused OPN (rat His-OPN) to the implant site via soluble injection (up to 72% mitigation achieved) or adsorption onto the implant materials (up to 91% mitigation achieved).	Histidine	110-119	secreted phosphoprotein 1	Rattus norvegicus	139-142
15812576-6	2005	Direct rescue of the calcification phenotype was achieved by the administration of exogenous recombinant rat, histidine-fused OPN (rat His-OPN) to the implant site via soluble injection (up to 72% mitigation achieved) or adsorption onto the implant materials (up to 91% mitigation achieved).	Histidine	135-138	secreted phosphoprotein 1	Mus musculus	126-129
15812576-6	2005	Direct rescue of the calcification phenotype was achieved by the administration of exogenous recombinant rat, histidine-fused OPN (rat His-OPN) to the implant site via soluble injection (up to 72% mitigation achieved) or adsorption onto the implant materials (up to 91% mitigation achieved).	Histidine	135-138	secreted phosphoprotein 1	Rattus norvegicus	139-142
15812576-8	2005	The maximum anti-calcific effect was achieved only when rat His-OPN was adequately phosphorylated and contained a functional arginine-glycine-aspartate (RGD) cell adhesive domain.	Histidine	60-63	secreted phosphoprotein 1	Rattus norvegicus	64-67
15812576-9	2005	Furthermore, CAII levels in host cells surrounding GFBP were greatest when phosphorylated, RGD-containing rat His-OPN was adsorbed.	Histidine	110-113	secreted phosphoprotein 1	Rattus norvegicus	114-117
15747135-3	2005	We have studied the Co(II)- and Zn(II)-binding of a series of derivatives of L36, a small zinc ribbon protein containing a (Cys)(3)His metal coordination site.	Histidine	131-134	ribosomal protein L36	Homo sapiens	77-80
15735016-1	2005	We used gene targeting in mice to insert a His(6)-tagged mouse c-Myc cDNA, Myc(His), head to head into the mouse immunoglobulin heavy-chain locus, Igh, just 5" of the intronic enhancer, Emu.	Histidine	43-46	myelocytomatosis oncogene	Mus musculus	75-78
15569679-3	2005	A recombinant toxin, His-Css4, was obtained when fused to a His tag and a thrombin cleavage site and had similar binding affinity for and effect on Na currents of rat brain sodium channels as those of the native toxin isolated from the scorpion venom.	Histidine	21-24	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	25-29
15572352-4	2005	A defect in the uptake of histidine, lysine, or arginine was also observed in the vacuolar membrane vesicles of mutants YBR293w (VBA2) and YCL069w (VBA3).	Histidine	26-35	Vba2p	Saccharomyces cerevisiae S288C	129-133
15572352-4	2005	A defect in the uptake of histidine, lysine, or arginine was also observed in the vacuolar membrane vesicles of mutants YBR293w (VBA2) and YCL069w (VBA3).	Histidine	26-35	basic amino acid transporter	Saccharomyces cerevisiae S288C	148-152
15686464-6	2005	The dissociation constants of ristocetin-induced (125)I-labelled VWF binding to two forms of soluble recombinant GPIb alpha [(1)His-(302)Ala, either (145)Thr (145T) or (145)Met (145M)] were not different.	Histidine	128-131	von Willebrand factor	Cricetulus griseus	65-68
15576555-0	2005	Crystal structure of the histidine-containing phosphotransfer protein ZmHP2 from maize.	Histidine	25-34	histidine-containing phosphotransfer protein 2	Zea mays	70-75
15576555-5	2005	In ZmHP2, almost all of the conserved residues among plant HPt proteins surround this histidine, probably forming the docking interface for the receiver domain of histidine kinase or the response regulator.	Histidine	86-95	histidine-containing phosphotransfer protein 2	Zea mays	3-8
15906520-1	2005	OBJECTIVE: To investigate the loss of heterozygosity (LOH) and microsatellite instability (MSI) of fragile histidine triad (FHIT) gene in laryngeal squamous cell carcinoma (LSCC).	Histidine	107-116	fragile histidine triad diadenosine triphosphatase	Homo sapiens	124-128
15337768-8	2004	FA2H also contains the iron-binding histidine motif conserved among membrane-bound desaturases/hydroxylases.	Histidine	36-45	fatty acid 2-hydroxylase	Homo sapiens	0-4
15569992-1	2004	The fragile histidine triad (FHIT) gene located on chromosome 3p14.2 is frequently deleted in human tumors.	Histidine	12-21	fragile histidine triad diadenosine triphosphatase	Homo sapiens	29-33
15474520-2	2004	Through the use of positional scanning combinatorial substrate libraries, prostasin was shown to have a preference for poly-basic substrates: in position P4 preference was for arginine or lysine; in P3 preference was for histidine, lysine or arginine; in P2 preference was for basic or large hydrophobic amino acids; and in P1 preference was for arginine and lysine.	Histidine	221-230	serine protease 8	Homo sapiens	74-83
15474520-7	2004	In the presence of sub-inhibitory concentrations of zinc, the activity of prostasin increased several-fold and its substrate specificity was significantly altered in favor of a strong preference for histidine in positions P3 or P4 of the substrate.	Histidine	199-208	serine protease 8	Homo sapiens	74-83
15361849-1	2004	Abnormalities in the expression of the tumour suppressor fragile histidine triad (FHIT) gene have been reported in a variety of human tumours, including lung cancer and restoration of its expression in cancer cell lines resulted in the inhibition of proliferation and apoptosis induction.	Histidine	65-74	fragile histidine triad diadenosine triphosphatase	Homo sapiens	82-86
15544487-1	2004	Gonadotropin-releasing hormone (GnRH) or luteinizing hormone-releasing hormone (LHRH) is a decapeptide (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2) hypothalamic hormone that acts upon 7-trans membrane spanning GnRH receptors in the pituitary.	Histidine	109-112	gonadotropin releasing hormone 1	Homo sapiens	0-30
15544487-1	2004	Gonadotropin-releasing hormone (GnRH) or luteinizing hormone-releasing hormone (LHRH) is a decapeptide (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2) hypothalamic hormone that acts upon 7-trans membrane spanning GnRH receptors in the pituitary.	Histidine	109-112	gonadotropin releasing hormone 1	Homo sapiens	32-36
15573771-1	2004	OBJECTIVE: To explore the relationship between reduction of FHIT expression of fragile histidine triad (FHIT) and the development of cervical carcinoma.	Histidine	87-96	fragile histidine triad diadenosine triphosphatase	Homo sapiens	60-64
15573771-1	2004	OBJECTIVE: To explore the relationship between reduction of FHIT expression of fragile histidine triad (FHIT) and the development of cervical carcinoma.	Histidine	87-96	fragile histidine triad diadenosine triphosphatase	Homo sapiens	104-108
21085684-2	2010	Two classical PLDs, PLD1 and PLD2, contain phosphatidylinositide-binding PX and PH domains and two conserved His-x-Lys-(x)(4)-Asp (HKD) motifs, which are critical for PLD activity.	Histidine	109-112	phospholipase D1	Mus musculus	20-24
21051640-3	2010	EF-Tu is in its active conformation, the switch I loop is ordered, and the catalytic histidine is coordinating the nucleophilic water in position for inline attack on the gamma-phosphate of GTP.	Histidine	85-94	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	0-5
25577831-8	2014	Some of the recombinant hZP3 with His-tag could bind affinity matrix and got purified but most of the solubilized hZP3 passed through and the reasons remained unknown.	Histidine	34-37	zona pellucida glycoprotein 3	Homo sapiens	24-28
15304516-8	2004	Classical pathway regulation, both through decay acceleration and factor I cleavage of C4b, required a cluster of positively charged amino acids in CCP1 stretching into CCP2 (Arg-20, Arg-33, Arg-35, Lys-64, Lys-65, and Lys-88) as well as positively (Lys-131, Lys-133, and His-135) and negatively (Glu-99, Glu-152, and Asp-155) charged areas at opposing faces of the border region between CCPs 2 and 3.	Histidine	272-275	complement C4B (Chido blood group)	Homo sapiens	87-90
25490830-3	2014	Afterward, CS, which exhibited five different molecular weights and deacetylation degrees, was complexed with pIRES2-EGFP-hBMP2-His to form CS/pIRES2-EGFP-hBMP2-His nanoparticles; in this procedure, a desolvent method was used at different N/P ratios (amino in CS to phospho in plasmid DNA).	Histidine	128-131	bone morphogenetic protein 2	Homo sapiens	122-127
15377847-2	2004	A common arginine (R) to histidine (H) polymorphism at amino acid position 213 influences SULT1A1 activity and has been suggested as risk factor for a different types of cancers.	Histidine	25-34	sulfotransferase family 1A member 1	Homo sapiens	90-97
20979597-6	2010	As only TIP39 causes internalisation of the receptor and the primary difference being an aspartic acid in position 7 of TIP39 that interacts with histidine 396 in the receptor, versus isoleucine/histidine residues in the related hormones, this might be a trigger interaction for the events that cause internalisation.	Histidine	146-155	parathyroid hormone 2	Homo sapiens	120-125
25490830-3	2014	Afterward, CS, which exhibited five different molecular weights and deacetylation degrees, was complexed with pIRES2-EGFP-hBMP2-His to form CS/pIRES2-EGFP-hBMP2-His nanoparticles; in this procedure, a desolvent method was used at different N/P ratios (amino in CS to phospho in plasmid DNA).	Histidine	128-131	bone morphogenetic protein 2	Homo sapiens	155-160
20979597-7	2010	CONCLUSIONS: A model is constructed for the complex and a trigger interaction for full agonistic activation between aspartic acid 7 of TIP39 and histidine 396 in the receptor is proposed.	Histidine	145-154	parathyroid hormone 2	Homo sapiens	135-140
25490830-3	2014	Afterward, CS, which exhibited five different molecular weights and deacetylation degrees, was complexed with pIRES2-EGFP-hBMP2-His to form CS/pIRES2-EGFP-hBMP2-His nanoparticles; in this procedure, a desolvent method was used at different N/P ratios (amino in CS to phospho in plasmid DNA).	Histidine	161-164	bone morphogenetic protein 2	Homo sapiens	122-127
15627891-0	2004	Aberrations in the fragile histidine triad(FHIT) gene may be involved in lung carcinogenesis in patients with chronic pulmonary tuberculosis.	Histidine	27-36	fragile histidine triad diadenosine triphosphatase	Homo sapiens	43-47
25490830-3	2014	Afterward, CS, which exhibited five different molecular weights and deacetylation degrees, was complexed with pIRES2-EGFP-hBMP2-His to form CS/pIRES2-EGFP-hBMP2-His nanoparticles; in this procedure, a desolvent method was used at different N/P ratios (amino in CS to phospho in plasmid DNA).	Histidine	161-164	bone morphogenetic protein 2	Homo sapiens	155-160
25490830-7	2014	2) CS/pIRES2-EGFP-hBMP2-His nanoparticles were synthesized and pIRES2-EGFP-hBMP2-His was packaged by CS.	Histidine	24-27	bone morphogenetic protein 2	Homo sapiens	18-23
20812745-5	2010	We report that when a single amino acid within the MoFe protein (beta-98(Tyr)) is substituted by His, the resulting MoFe protein supports catalytic reduction of the nitrogenous substrate hydrazine (N(2)H(4)) to two ammonia molecules when provided with a low potential reductant, polyaminocarboxylate ligated Eu(II) (E(m) -1.1 V vs NHE).	Histidine	97-100	solute carrier family 9 member C1	Homo sapiens	331-334
25490830-7	2014	2) CS/pIRES2-EGFP-hBMP2-His nanoparticles were synthesized and pIRES2-EGFP-hBMP2-His was packaged by CS.	Histidine	81-84	bone morphogenetic protein 2	Homo sapiens	18-23
25490830-7	2014	2) CS/pIRES2-EGFP-hBMP2-His nanoparticles were synthesized and pIRES2-EGFP-hBMP2-His was packaged by CS.	Histidine	81-84	bone morphogenetic protein 2	Homo sapiens	75-80
24867409-6	2014	There are at least two binding sites for divalent metal ions binding to the C-terminal domain of Hv1, either of which is close to His(244) or His(266) residue.	Histidine	130-133	hydrogen voltage gated channel 1	Homo sapiens	97-100
20628046-0	2010	The identification of Histidine 712 as a critical residue for constitutive TRPV5 internalization.	Histidine	22-31	transient receptor potential cation channel, subfamily V, member 5	Mus musculus	75-80
20628046-5	2010	Removal of amino acid His(712) elevated the [Ca(2+)](i), indicating enlarged TRPV5 activity.	Histidine	22-25	transient receptor potential cation channel, subfamily V, member 5	Mus musculus	77-82
20628046-6	2010	In addition, substitution of the positively charged His(712) for a negative (H712D) or neutral (H712N) amino acid also stimulated TRPV5 activity.	Histidine	52-55	transient receptor potential cation channel, subfamily V, member 5	Mus musculus	130-135
20628046-7	2010	This critical role of His(712) was confirmed by patch clamp analysis, which demonstrates increased Na(+) and Ca(2+) currents for TRPV5-H712D.	Histidine	22-25	transient receptor potential cation channel, subfamily V, member 5	Mus musculus	129-134
15313924-1	2004	The antiangiogenic activity of the multidomain plasma protein histidine-proline-rich glycoprotein (HPRG) is localized to its histidine-proline-rich (H/P) domain and has recently been shown to be mediated, at least partially, through binding to cell-surface tropomyosin in fibroblast growth factor-2-activated endothelial cells (X. Guan et al., Thromb Haemost, in press).	Histidine	62-71	fibroblast growth factor 2	Mus musculus	272-298
15273299-6	2004	The reaction PQQ--&gt;PQQH- occurs with Glu 171-CO2- and His 144-Im as the base species in MDH and sGDH, respectively.	Histidine	57-60	NADH:ubiquinone oxidoreductase subunit B5	Homo sapiens	99-103
20628046-11	2010	Together, these results demonstrate that His(712) plays an essential role in plasma membrane regulation of TRPV5 via a constitutive endocytotic mechanism.	Histidine	41-44	transient receptor potential cation channel, subfamily V, member 5	Mus musculus	107-112
24867409-6	2014	There are at least two binding sites for divalent metal ions binding to the C-terminal domain of Hv1, either of which is close to His(244) or His(266) residue.	Histidine	142-145	hydrogen voltage gated channel 1	Homo sapiens	97-100
15182206-0	2004	The mechanism of action of the fragile histidine triad, Fhit: isolation of a covalent adenylyl enzyme and chemical rescue of H96G-Fhit.	Histidine	39-48	fragile histidine triad diadenosine triphosphatase	Homo sapiens	56-60
15182206-0	2004	The mechanism of action of the fragile histidine triad, Fhit: isolation of a covalent adenylyl enzyme and chemical rescue of H96G-Fhit.	Histidine	39-48	fragile histidine triad diadenosine triphosphatase	Homo sapiens	130-134
24754256-1	2014	Membrane transporter PhT2 (SLC15A3), which belongs to the proton-coupled oligopeptide transporter family, mediates the transport of di/tripeptides and histidine utilizing an inwardly directed proton gradient and negative membrane potential.	Histidine	151-160	solute carrier family 15, member 3	Mus musculus	27-34
15182206-1	2004	The human fragile histidine triad protein Fhit catalyzes the Mg(2+)-dependent hydrolysis of P(1)-5"-O-adenosine-P(3)-5"-O-adenosine triphosphate, Ap(3)A, to AMP and ADP.	Histidine	18-27	fragile histidine triad diadenosine triphosphatase	Homo sapiens	42-46
15208030-3	2004	The replacement of histidine 236 from hIKCa1 channel with a smaller amino acid, cystein, did not change MTX binding affinity, however, partially affected the pH0 dependency of its block at low pH0.	Histidine	19-28	potassium calcium-activated channel subfamily N member 4	Homo sapiens	38-44
20799012-8	2010	These results suggest that Tyr/His(1) and Ile/Thr(7) of GIP/GLP-1 peptides confer differential ligand selectivity toward GIPR and GLP1R.	Histidine	31-34	glucagon like peptide 1 receptor	Homo sapiens	130-135
24799395-6	2014	Bond Critical Points (BCP) information between the minor groove of the DNA and the metallopeptides shows an increase in electronic density between Gly(1) , the His residues, and the oxygen atoms of the thymine nucleotide.	Histidine	160-163	threonine aldolase 1, pseudogene	Homo sapiens	147-153
21162995-7	2010	77-amino acid of Vpr protein had three polymorphism forms as Arginin, Glutamine and Histidine, with Glutamine as the wild form.	Histidine	84-93	Vpr	Human immunodeficiency virus 1	17-20
24464917-1	2014	UNLABELLED: In many cancers, including lung carcinomas, Fragile histidine triad (Fhit) is frequently decreased or lost.	Histidine	64-73	fragile histidine triad diadenosine triphosphatase	Homo sapiens	81-85
20689140-0	2010	Homozygous deletion but not mutation of exons 5 and 8 of the fragile histidine triad (FHIT) gene is associated with features of differentiated thyroid carcinoma.	Histidine	69-78	fragile histidine triad diadenosine triphosphatase	Homo sapiens	86-90
20689140-1	2010	The fragile histidine triad (FHIT) gene encompasses the most common human fragile site, FRA3B at 3p14.2, a region that is involved in homozygous deletions in a variety of human tumors.	Histidine	12-21	fragile histidine triad diadenosine triphosphatase	Homo sapiens	29-33
20689140-1	2010	The fragile histidine triad (FHIT) gene encompasses the most common human fragile site, FRA3B at 3p14.2, a region that is involved in homozygous deletions in a variety of human tumors.	Histidine	12-21	fragile histidine triad diadenosine triphosphatase	Homo sapiens	88-93
15154840-2	2004	The biotinylated and histidine-tagged subunits of the bacterial F(0)F(1)-ATPase complex were used for immobilization of the complex on artificial semi-permeable membranes resulting in 88+/-7.8 and 72+/-5.2% coupling of the enzymes.	Histidine	21-30	ATP synthase F1 subunit epsilon	Homo sapiens	64-79
15214434-1	2004	The influence of the two histidine and two arginine residues of mast cell degranulating peptide (MCD) in activity and binding was studied by replacing these amino acids in the MCD sequence with L-alanine.	Histidine	25-34	mucin 1, cell surface associated	Homo sapiens	97-100
15214434-7	2004	The analogs Ala8 (for His) and Ala16 (for Arg) showed the same binding affinities as MCD, whereas analog Ala7 (for Arg) and analog Ala13 (for His) showed slightly better binding affinity than the parent compound.	Histidine	22-25	mucin 1, cell surface associated	Homo sapiens	85-88
20589574-10	2010	The results indicated that the both EIF1 fusion proteins with the N-terminally His-tagged form gave rise to the accumulation of two expected 19 kDa polypeptide.	Histidine	79-82	eukaryotic translation initiation factor 1	Ailuropoda melanoleuca	36-40
25059370-1	2014	OBJECTIVE: To explore the effect of folate on cell proliferation and apoptosis as well as on DNA methylation, expression of mRNA and protein of fragile histidine triad (FHIT)gene in cervical cancer cells.	Histidine	152-161	fragile histidine triad diadenosine triphosphatase	Homo sapiens	169-173
20411530-4	2010	Dpl is able to bind at least one copper ion, and the specific metal-binding site has been identified as the histidine residue at the beginning of the third helical region.	Histidine	108-117	prion like protein doppel	Homo sapiens	0-3
15147186-3	2004	The zinc ligands in D-CDA are one histidine and two cysteine residues, whereas in T-CDA zinc is coordinated to three cysteines.	Histidine	34-43	cytidine deaminase	Homo sapiens	22-25
15147186-6	2004	Moreover, one of the zinc-liganding cysteines has been substituted by histidine to mimic D-CDA, alone (C53H) and in combination with R56Q (C53H/R56Q).	Histidine	70-79	cytidine deaminase	Homo sapiens	91-94
24570481-2	2014	We show here that the expression of C. albicans GCN4, which encodes a transcription factor that regulates morphogenetic and metabolic responses, is translationally regulated in response to amino acid starvation induced by exposure to the histidine analog 3-aminotriazole (3AT).	Histidine	238-247	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	48-52
15122909-1	2004	Metal response element (MRE) binding transcription factor-1 (MTF1) is a six Cys(2)His(2) zinc finger-containing transcription factor required for basal and zinc-induced transcription of metallothionein genes.	Histidine	82-85	metal regulatory transcription factor 1	Homo sapiens	0-59
15122909-1	2004	Metal response element (MRE) binding transcription factor-1 (MTF1) is a six Cys(2)His(2) zinc finger-containing transcription factor required for basal and zinc-induced transcription of metallothionein genes.	Histidine	82-85	metal regulatory transcription factor 1	Homo sapiens	61-65
15122671-1	2004	The intracellular pH (pHi) of a series of cancer cell lines was determined using the pH-sensitive indicators imidazole (Im) or histidine (His) and diffusion-weighted (DW) proton NMR spectroscopy.	Histidine	127-136	glucose-6-phosphate isomerase	Homo sapiens	22-25
15122671-1	2004	The intracellular pH (pHi) of a series of cancer cell lines was determined using the pH-sensitive indicators imidazole (Im) or histidine (His) and diffusion-weighted (DW) proton NMR spectroscopy.	Histidine	138-141	glucose-6-phosphate isomerase	Homo sapiens	22-25
20622329-1	2010	OBJECTIVE: To determine the role of fragile histidine triad (FHIT) and MDM2 in carcinogenesis of oral submucous fibrosis (OSF).	Histidine	44-53	fragile histidine triad diadenosine triphosphatase	Homo sapiens	61-65
19768521-4	2010	Thus we analyzed the D-amino acid contents of His-tag-purified beta-galactosidase and human urocortin, which were synthesized by Escherichia coli grown in controlled synthetic media.	Histidine	46-49	galactosidase beta 1	Homo sapiens	63-81
15093672-3	2004	A functional polymorphism of the SULT1A1 gene has been implicated in a decreased activity and thermostability when the wild-type arginine (Arg) at codon 213 is substituted by a histidine (His).	Histidine	177-186	sulfotransferase family 1A member 1	Homo sapiens	33-40
15093672-3	2004	A functional polymorphism of the SULT1A1 gene has been implicated in a decreased activity and thermostability when the wild-type arginine (Arg) at codon 213 is substituted by a histidine (His).	Histidine	188-191	sulfotransferase family 1A member 1	Homo sapiens	33-40
24757411-0	2014	Fragile histidine triad (FHIT) suppresses proliferation and promotes apoptosis in cholangiocarcinoma cells by blocking PI3K-Akt pathway.	Histidine	8-17	fragile histidine triad diadenosine triphosphatase	Homo sapiens	25-29
24757411-1	2014	Fragile histidine triad (FHIT) is a tumor suppressor protein that regulates cancer cell proliferation and apoptosis.	Histidine	8-17	fragile histidine triad diadenosine triphosphatase	Homo sapiens	25-29
24374040-4	2014	Two polymorphisms of LMP2-60 (Arg His) and LMP7-145 (Gln Lys) were identified by PCR-RFLP (RFLP, restriction fragment length polymorphism) method.	Histidine	34-37	proteasome 20S subunit beta 9	Homo sapiens	21-25
14961766-1	2004	HDC (L-histidine decarboxylase), the enzyme responsible for the catalytic production of histamine from L-histidine, belongs to an evolutionarily conserved family of vitamin B6-dependent enzymes known as the group II decarboxylases.	Histidine	5-16	histidine decarboxylase	Homo sapiens	0-3
14961766-6	2004	This involves a protease sensitive loop, and incubating recombinant HDC with an L-histidine substrate analogue altered enzyme structure so that the loop was no longer exposed for tryptic proteolysis.	Histidine	80-91	histidine decarboxylase	Homo sapiens	68-71
20418308-13	2010	CONCLUSIONS: LCT and LCT/MCT emulsions reversed the lengthening of His ventricle, QRS, atrial-His, and PQ intervals induced by the IV injection of 4 mg .	Histidine	67-70	lactase	Homo sapiens	13-16
24240276-7	2014	The uracil base at the extreme 3" end is sandwiched by His 36 and Arg 69 from Lsm3, through pi-pi and cation-pi interactions, respectively.	Histidine	55-58	LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated	Homo sapiens	78-82
20418308-13	2010	CONCLUSIONS: LCT and LCT/MCT emulsions reversed the lengthening of His ventricle, QRS, atrial-His, and PQ intervals induced by the IV injection of 4 mg .	Histidine	67-70	lactase	Homo sapiens	21-24
14715079-4	2004	Two missense mutations in the C-terminal domain of Smad4, D351H (Asp351--&gt;His) and D537Y (Asp537--&gt;Tyr), have been described recently in the human colorectal cancer cell lines CACO-2 and SW948 respectively [Woodford-Richens, Rowan, Gorman, Halford, Bicknell, Wasan, Roylance, Bodmer and Tomlinson (2001) Proc.	Histidine	77-80	SMAD family member 4	Homo sapiens	51-56
15168591-2	2004	In 1996 the fragile histidine triad (FHIT) gene was isolated from the region encompassing the most active fragile FRA3B locus, and recently the WW domain-containing oxidoreductase gene (WWOX) was identified at FRA16D.	Histidine	20-29	fragile histidine triad diadenosine triphosphatase	Homo sapiens	37-41
15168591-2	2004	In 1996 the fragile histidine triad (FHIT) gene was isolated from the region encompassing the most active fragile FRA3B locus, and recently the WW domain-containing oxidoreductase gene (WWOX) was identified at FRA16D.	Histidine	20-29	fragile histidine triad diadenosine triphosphatase	Homo sapiens	114-119
20226173-6	2010	Results showed that TOP His(600) residue makes important interactions with the substrate, supporting the prediction that His(600) moves toward the substrate due to a hinge movement similar to the Dcp and ACE-2.	Histidine	24-27	angiotensin converting enzyme 2	Homo sapiens	204-209
24338687-6	2014	X-ray crystallographic studies of chronophin(A194K,A195K) revealed that dimer formation is essential for an intermolecular arginine-arginine-tryptophan stacking interaction that positions a critical histidine residue in the substrate specificity loop of chronophin for PLP coordination.	Histidine	199-208	pyridoxal phosphatase	Homo sapiens	34-44
20226173-6	2010	Results showed that TOP His(600) residue makes important interactions with the substrate, supporting the prediction that His(600) moves toward the substrate due to a hinge movement similar to the Dcp and ACE-2.	Histidine	121-124	angiotensin converting enzyme 2	Homo sapiens	204-209
19526311-5	2010	Furthermore, the MS/MS fragmentation pattern of TRH has been investigated to develop a selected reaction monitoring (SRM) method that allows the detection of a specific b2 product ion at m/z 249.1, corresponding to the N-terminus dipeptide pyroglutamic acid-histidine.	Histidine	258-267	thyrotropin releasing hormone	Rattus norvegicus	48-51
14699136-6	2004	Consistent with this observation, substitution of the equivalent His(140) enabled EP3beta to stimulate cAMP formation with the rank order of Phe &gt; Tyr &gt; Trp &gt; Leu.	Histidine	65-68	epididymal protein 3B	Homo sapiens	82-89
24333423-6	2014	To directly evaluate the effects of cholesterol on HAS activity, a recombinant human HAS2 protein with a histidine-tag was expressed as a membrane protein by using a baculovirus system, then successfully solubilized, and isolated by affinity chromatography.	Histidine	105-114	hyaluronan synthase 2	Homo sapiens	85-89
15032614-2	2004	In 1996, the human fragile histidine triad gene, FHIT, was identified by positional cloning of the chromosome region spanning the carcinogen-sensitive, common fragile site, FRA3B at 3p14.2.	Histidine	27-36	fragile histidine triad diadenosine triphosphatase	Homo sapiens	49-53
15032614-2	2004	In 1996, the human fragile histidine triad gene, FHIT, was identified by positional cloning of the chromosome region spanning the carcinogen-sensitive, common fragile site, FRA3B at 3p14.2.	Histidine	27-36	fragile histidine triad diadenosine triphosphatase	Homo sapiens	173-178
15012592-3	2004	In the present study, a novel His(7)-modified analogue of GLP-1, N-pyroglutamyl-GLP-1, as well as N-acetyl-GLP-1 were synthesised and tested for DPP IV stability and biological activity.	Histidine	30-33	glucagon like peptide 1 receptor	Homo sapiens	58-63
20206584-10	2010	Mass-spectrometric analysis subsequently identified a histidine-related degradation product associated with the CDR2 of the heavy chain.	Histidine	54-63	cerebellar degeneration related protein 2	Homo sapiens	112-116
25486479-1	2014	Fragile histidine triad (FHIT) gene deletions are among the earliest and most frequent events in carcinogenesis, particularly in carcinogen-exposed tissues.	Histidine	8-17	fragile histidine triad diadenosine triphosphatase	Homo sapiens	25-29
20033706-1	2010	BACKGROUND: The human fragile histidine triad (FHIT) gene is a putative tumor suppressor gene, which is located at chromosome region 3p14.2.	Histidine	30-39	fragile histidine triad diadenosine triphosphatase	Homo sapiens	47-51
14760383-1	2004	The fragile histidine triad (FHIT) gene, encompassing the FRA3B fragile site at chromosome 3p14.2, is a candidate tumour suppressor gene involved in a variety of tumours, including gastric carcinomas.	Histidine	12-21	fragile histidine triad diadenosine triphosphatase	Homo sapiens	29-33
14760383-1	2004	The fragile histidine triad (FHIT) gene, encompassing the FRA3B fragile site at chromosome 3p14.2, is a candidate tumour suppressor gene involved in a variety of tumours, including gastric carcinomas.	Histidine	12-21	fragile histidine triad diadenosine triphosphatase	Homo sapiens	58-63
24063889-6	2013	Cu(2+) interacts with at least two conserved histidines, at positions 72 and 95 modifying the structure of native monomeric CSTB.	Histidine	45-55	cystatin B	Rattus norvegicus	124-128
15176429-3	2004	Direct sequencing of the calsequestrin 2 (CASQ2), a candidate gene from within the linkage interval, revealed a negatively charged aspartic acid change to a positively charged histidine at position 307 of the protein.	Histidine	176-185	calsequestrin 2	Homo sapiens	25-40
15176429-3	2004	Direct sequencing of the calsequestrin 2 (CASQ2), a candidate gene from within the linkage interval, revealed a negatively charged aspartic acid change to a positively charged histidine at position 307 of the protein.	Histidine	176-185	calsequestrin 2	Homo sapiens	42-47
21222265-3	2010	alpha-Melanocyte stimulating hormone is a tridecapeptide, with the core sequence His(6)-Phe(7)-Arg(8)-Trp(9) shared with beta- and gamma-MSH and identified as essential for receptor activation and stimulation of pigmentation.	Histidine	81-84	pro-opiomelanocortin-alpha	Mus musculus	0-36
24219289-7	2013	(iv) His-CIRH1A is phosphorylated at Thr(131) by a mitotic Xenopus egg extract, and binding with GST-UTP15 and GST-WDR43 is suppressed.	Histidine	5-8	WD repeat domain 43 L homeolog	Xenopus laevis	115-120
20671953-9	2010	In Glo I lenses, formation of AGEs was significantly inhibited; the argpyrimidine levels were 82 +/- 18 pmoles/mg protein, and the HI levels were 2.6 +/- 2.3 units/mug protein.	Histidine	131-133	gulonolactone (L-) oxidase	Mus musculus	3-6
15752073-3	2004	This family of hypothetical proteins is referred to as SDH proteinase family based on conserved sequential order of Ser, Asp and His residues and predicted serine proteinase activity.	Histidine	129-132	serine dehydratase	Homo sapiens	55-58
15752073-5	2004	However, the best sequence alignment we could obtain suggests that while catalytic Ser is conserved across Clp and SDH proteinases the location of the other catalytic triad residues, namely, His and Asp are swapped in their amino acid alignment positions and hence in 3-D structure.	Histidine	191-194	serine dehydratase	Homo sapiens	115-118
14569398-4	2004	The FHIT (fragile histidine triad) tumour suppressor gene, located at 3p14.2, has been proposed to be a target to major human lung carcinogens, such as tobacco smoke and asbestos.	Histidine	18-27	fragile histidine triad diadenosine triphosphatase	Homo sapiens	4-8
24579380-5	2013	A histidine residue, which is conserved across all functional sucrose transporter proteins in higher plants, is located at position 66 of the BnSUT1C.	Histidine	2-11	sucrose transport protein SUC1	Brassica napus	62-81
14680799-2	2003	Expression of a soluble form of recombinant histidine-tagged XT-I (rXT-I-HIS) was accomplished at a high level with High Five/pCG255-1 insect cells in suspension culture.	Histidine	44-53	xylosyltransferase 1	Homo sapiens	61-65
19819873-2	2009	Multiple sequence alignment of human M1 aminopeptidase revealed that the first Gly residue within the conserved exopeptidase motif of the M1 family, GXMEN motif, is uniquely substituted for His in human LVRN/APQ.	Histidine	190-193	laeverin	Homo sapiens	203-211
19819873-3	2009	In this study, we evaluated the roles of nonconserved His(379), comprising the exopeptidase motif in the enzymatic properties of human LVRN/APQ.	Histidine	54-57	laeverin	Homo sapiens	135-139
19819873-3	2009	In this study, we evaluated the roles of nonconserved His(379), comprising the exopeptidase motif in the enzymatic properties of human LVRN/APQ.	Histidine	54-57	laeverin	Homo sapiens	140-143
24579380-5	2013	A histidine residue, which is conserved across all functional sucrose transporter proteins in higher plants, is located at position 66 of the BnSUT1C.	Histidine	2-11	sucrose transport protein SUC1	Brassica napus	142-149
14643027-12	2003	In conclusion, this study provides epidemiologic evidence of a reduced bladder cancer risk associated with the SULT1A1 His(213) polymorphism.	Histidine	119-122	sulfotransferase family 1A member 1	Homo sapiens	111-118
24045953-8	2013	Photocross-linking of synthetic ghrelin analogs and inhibitors demonstrates binding to the C-terminal region of GOAT, consistent with a role of His-338 in the active site.	Histidine	144-147	appetite-regulating hormone	Capra hircus	32-39
14695704-1	2003	BACKGROUND/AIMS: The fragile histidine triad (FHIT) gene located at chromosome 3p14.2, is a candidate tumor suppressor gene often involved in various tumors.	Histidine	29-38	fragile histidine triad diadenosine triphosphatase	Homo sapiens	46-50
14584947-3	2003	To probe the receptor active conformation of the pharmacophore His-Phe-Arg-Trp in gamma-MSH, two different series of gamma-MSH analogues have been designed and synthesized and their biological activities determined at hMC3R, hMC4R, and hMC5R.	Histidine	63-66	melanocortin 3 receptor	Homo sapiens	218-223
19771477-3	2009	Squirrel RNase 1 genes encode typical RNase A ribonucleases, each with eight cysteines, a conserved CKXXNTF signature motif, and a canonical His(12)-Lys(41)-His(119) catalytic triad.	Histidine	141-144	ribonuclease A family member 1, pancreatic	Homo sapiens	9-16
19771477-3	2009	Squirrel RNase 1 genes encode typical RNase A ribonucleases, each with eight cysteines, a conserved CKXXNTF signature motif, and a canonical His(12)-Lys(41)-His(119) catalytic triad.	Histidine	157-160	ribonuclease A family member 1, pancreatic	Homo sapiens	9-16
24021113-9	2013	Simulations of RhCG also reveal that the signature histidine dyad is occasionally exposed to the extracellular bulk, which is never observed in AmtB.	Histidine	51-60	Rh family C glycoprotein	Homo sapiens	15-19
19722713-2	2009	Unprecedented photochemical, site-selective cleavage of a His-Trp (HW) motif in the GH1 family TIM-barrel proteins is observed upon exposure to 240-308 nm light to cleanly release N-terminal primary amide and C-terminal indolylenamide fragments.	Histidine	58-61	Rho guanine nucleotide exchange factor 5	Homo sapiens	95-98
14678517-2	2003	In 1996, the human fragile histidine triad gene, FHIT, was identified by positional cloning at 3p14.2, a chromosomal region spanning the carcinogen-sensitive, common fragile site FRA3B.	Histidine	27-36	fragile histidine triad diadenosine triphosphatase	Homo sapiens	49-53
19487247-1	2009	An N-terminal domain histidine [corresponding to position 39 of UDP-glucuronosyltransferase (UGT) 1A1] is conserved in all UGT1A and UGT2B subfamily proteins except UGT1A4 (Pro-40) and UGT2B10 (Leu-34).	Histidine	21-30	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	123-128
24086630-10	2013	T cells from hi-dose sensitized mice showed a robust increase in TGF-b production, and Treg from these mice were able to efficiently suppress effector T cell proliferation in vitro.	Histidine	13-15	transforming growth factor, beta 1	Mus musculus	65-70
19487247-5	2009	The conserved N-terminal domain histidine of UGT1A1, UGT1A6, UGT1A9, and UGT2B7 was mutated to proline and leucine 34 of UGT2B10 was substituted with histidine, and the capacity of the wild-type and mutant proteins to glucuronidate 4MU, 1NP, LTG, TFP, and naproxen was characterized.	Histidine	32-41	UDP glucuronosyltransferase family 1 member A6	Homo sapiens	53-59
19487247-5	2009	The conserved N-terminal domain histidine of UGT1A1, UGT1A6, UGT1A9, and UGT2B7 was mutated to proline and leucine 34 of UGT2B10 was substituted with histidine, and the capacity of the wild-type and mutant proteins to glucuronidate 4MU, 1NP, LTG, TFP, and naproxen was characterized.	Histidine	32-41	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	61-67
19487247-5	2009	The conserved N-terminal domain histidine of UGT1A1, UGT1A6, UGT1A9, and UGT2B7 was mutated to proline and leucine 34 of UGT2B10 was substituted with histidine, and the capacity of the wild-type and mutant proteins to glucuronidate 4MU, 1NP, LTG, TFP, and naproxen was characterized.	Histidine	150-159	UDP glucuronosyltransferase family 1 member A6	Homo sapiens	53-59
19487247-5	2009	The conserved N-terminal domain histidine of UGT1A1, UGT1A6, UGT1A9, and UGT2B7 was mutated to proline and leucine 34 of UGT2B10 was substituted with histidine, and the capacity of the wild-type and mutant proteins to glucuronidate 4MU, 1NP, LTG, TFP, and naproxen was characterized.	Histidine	150-159	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	61-67
14556983-2	2003	Histamine, synthesized by histidine decarboxylase (HDC) from L-histidine, plays an essential role in allergic and inflammatory processes and in cell differentiation.	Histidine	61-72	histidine decarboxylase	Mus musculus	26-49
14556983-2	2003	Histamine, synthesized by histidine decarboxylase (HDC) from L-histidine, plays an essential role in allergic and inflammatory processes and in cell differentiation.	Histidine	61-72	histidine decarboxylase	Mus musculus	51-54
12964015-1	2003	It is unclear how expression of the FHIT (fragile histidine triad) gene by the colorectal neoplasm correlates with histogenesis and progression of the disease.	Histidine	50-59	fragile histidine triad diadenosine triphosphatase	Homo sapiens	36-40
23912193-3	2013	An active mature CLV3 is a tridecapeptide linked to beta-L-Araf-(1 2)-beta-L-Araf-(1 2)-beta-L-Araf at a Hyp residue in the center of the peptide sequence such as Arg-Thr-Val-Hyp-Ser-Gly-Hyp(L-Arafn)-Asp-Pro-Leu-His-His-His (n = 3).	Histidine	212-215	CLAVATA3	Arabidopsis thaliana	17-21
14503883-6	2003	However, substitutions of Gly75 in the second binding loop of cystatin A by Trp or His, making the loop similar to those of cystatins C or B, respectively, increased the affinity for papain by approximately 10-fold.	Histidine	83-86	cystatin A	Homo sapiens	62-72
19587037-6	2009	Introduction of targeted amino acid mutations in the protease domain confirmed the importance of the putative Cys(55)- His(124) catalytic motif for nsp2/3 proteolysis in vitro, as were three additional conserved cysteine residues (Cys(111), Cys(142), and Cys(147)).	Histidine	119-122	reticulon 2	Homo sapiens	148-152
23912193-3	2013	An active mature CLV3 is a tridecapeptide linked to beta-L-Araf-(1 2)-beta-L-Araf-(1 2)-beta-L-Araf at a Hyp residue in the center of the peptide sequence such as Arg-Thr-Val-Hyp-Ser-Gly-Hyp(L-Arafn)-Asp-Pro-Leu-His-His-His (n = 3).	Histidine	212-215	alpha-L-arabinofuranosidase 1	Arabidopsis thaliana	59-63
23912193-3	2013	An active mature CLV3 is a tridecapeptide linked to beta-L-Araf-(1 2)-beta-L-Araf-(1 2)-beta-L-Araf at a Hyp residue in the center of the peptide sequence such as Arg-Thr-Val-Hyp-Ser-Gly-Hyp(L-Arafn)-Asp-Pro-Leu-His-His-His (n = 3).	Histidine	212-215	alpha-L-arabinofuranosidase 1	Arabidopsis thaliana	77-81
12969785-2	2003	The Fragile Histidine Triad (FHIT) gene, encompassing the FRA3B fragile site at chromosome 3p14.2, is a candidate tumor suppressor gene in a variety of human malignancies.	Histidine	12-21	fragile histidine triad diadenosine triphosphatase	Homo sapiens	29-33
19655810-0	2009	Histidine residues in the peptide D-Lys(6)-GnRH: potential for copolymerization in polymeric nanoparticles.	Histidine	0-9	gonadotropin releasing hormone 1	Homo sapiens	43-47
12969785-2	2003	The Fragile Histidine Triad (FHIT) gene, encompassing the FRA3B fragile site at chromosome 3p14.2, is a candidate tumor suppressor gene in a variety of human malignancies.	Histidine	12-21	fragile histidine triad diadenosine triphosphatase	Homo sapiens	58-63
23912193-3	2013	An active mature CLV3 is a tridecapeptide linked to beta-L-Araf-(1 2)-beta-L-Araf-(1 2)-beta-L-Araf at a Hyp residue in the center of the peptide sequence such as Arg-Thr-Val-Hyp-Ser-Gly-Hyp(L-Arafn)-Asp-Pro-Leu-His-His-His (n = 3).	Histidine	212-215	alpha-L-arabinofuranosidase 1	Arabidopsis thaliana	77-81
19655810-4	2009	MALDI TOF/TOF (tandem) analysis revealed that the histidine residue in position 2 of d-Lys(6)-GnRH interacts covalently in the polymerization process.	Histidine	50-59	gonadotropin releasing hormone 1	Homo sapiens	94-98
23912193-3	2013	An active mature CLV3 is a tridecapeptide linked to beta-L-Araf-(1 2)-beta-L-Araf-(1 2)-beta-L-Araf at a Hyp residue in the center of the peptide sequence such as Arg-Thr-Val-Hyp-Ser-Gly-Hyp(L-Arafn)-Asp-Pro-Leu-His-His-His (n = 3).	Histidine	216-219	CLAVATA3	Arabidopsis thaliana	17-21
23912193-3	2013	An active mature CLV3 is a tridecapeptide linked to beta-L-Araf-(1 2)-beta-L-Araf-(1 2)-beta-L-Araf at a Hyp residue in the center of the peptide sequence such as Arg-Thr-Val-Hyp-Ser-Gly-Hyp(L-Arafn)-Asp-Pro-Leu-His-His-His (n = 3).	Histidine	216-219	alpha-L-arabinofuranosidase 1	Arabidopsis thaliana	59-63
19540766-4	2009	The nucleoside-serine conjugate occupies the active site of RNase A and preferential perturbs the pK(a) value of His-119 by its "free amino group" as found from (1)H NMR studies.	Histidine	113-116	ribonuclease A family member 1, pancreatic	Homo sapiens	60-67
19540766-5	2009	Docking studies revealed that the free amino groups of the most active compounds are within hydrogen bonding distance of His-119 in inhibitor-RNase A complexes.	Histidine	121-124	ribonuclease A family member 1, pancreatic	Homo sapiens	142-149
12946947-2	2003	Connexin43 (Cx43) is abundantly expressed in the atrial and ventricular myocardium and the rapid ventricular conduction tissues (ie, His-Purkinje system) of the mammalian heart and is important to conduction through these cardiac tissues.	Histidine	133-136	gap junction protein alpha 1	Homo sapiens	0-10
23912193-3	2013	An active mature CLV3 is a tridecapeptide linked to beta-L-Araf-(1 2)-beta-L-Araf-(1 2)-beta-L-Araf at a Hyp residue in the center of the peptide sequence such as Arg-Thr-Val-Hyp-Ser-Gly-Hyp(L-Arafn)-Asp-Pro-Leu-His-His-His (n = 3).	Histidine	216-219	alpha-L-arabinofuranosidase 1	Arabidopsis thaliana	77-81
12946947-2	2003	Connexin43 (Cx43) is abundantly expressed in the atrial and ventricular myocardium and the rapid ventricular conduction tissues (ie, His-Purkinje system) of the mammalian heart and is important to conduction through these cardiac tissues.	Histidine	133-136	gap junction protein alpha 1	Homo sapiens	12-16
23912193-3	2013	An active mature CLV3 is a tridecapeptide linked to beta-L-Araf-(1 2)-beta-L-Araf-(1 2)-beta-L-Araf at a Hyp residue in the center of the peptide sequence such as Arg-Thr-Val-Hyp-Ser-Gly-Hyp(L-Arafn)-Asp-Pro-Leu-His-His-His (n = 3).	Histidine	216-219	alpha-L-arabinofuranosidase 1	Arabidopsis thaliana	77-81
23912193-3	2013	An active mature CLV3 is a tridecapeptide linked to beta-L-Araf-(1 2)-beta-L-Araf-(1 2)-beta-L-Araf at a Hyp residue in the center of the peptide sequence such as Arg-Thr-Val-Hyp-Ser-Gly-Hyp(L-Arafn)-Asp-Pro-Leu-His-His-His (n = 3).	Histidine	216-219	CLAVATA3	Arabidopsis thaliana	17-21
19486340-1	2009	Though the fragile histidine triad gene product, Fhit, was discovered and characterized as a tumor suppressor 13 years ago, its sequence, structure, and cellular location did not provide clues to aid discovery of its mechanisms of suppression.	Histidine	19-28	fragile histidine triad diadenosine triphosphatase	Homo sapiens	49-53
23912193-3	2013	An active mature CLV3 is a tridecapeptide linked to beta-L-Araf-(1 2)-beta-L-Araf-(1 2)-beta-L-Araf at a Hyp residue in the center of the peptide sequence such as Arg-Thr-Val-Hyp-Ser-Gly-Hyp(L-Arafn)-Asp-Pro-Leu-His-His-His (n = 3).	Histidine	216-219	alpha-L-arabinofuranosidase 1	Arabidopsis thaliana	59-63
21966230-3	2009	The day 28 anti-Tat specific IgG titer with his-Tat/Ni-NP was significantly greater than that with Alum/his-Tat.	Histidine	44-47	tyrosine aminotransferase	Mus musculus	16-19
21966230-3	2009	The day 28 anti-Tat specific IgG titer with his-Tat/Ni-NP was significantly greater than that with Alum/his-Tat.	Histidine	44-47	tyrosine aminotransferase	Mus musculus	48-51
12810727-2	2003	By use of site-directed mutagenesis and sequence comparisons, we have identified Cys-235, Asp-328, and His-362 as constituting a catalytic triad in human BACAT (hBACAT) and identifying BACAT as a member of the type I acyl-CoA thioesterase gene family.	Histidine	103-106	bile acid-CoA:amino acid N-acyltransferase	Homo sapiens	154-159
12810727-2	2003	By use of site-directed mutagenesis and sequence comparisons, we have identified Cys-235, Asp-328, and His-362 as constituting a catalytic triad in human BACAT (hBACAT) and identifying BACAT as a member of the type I acyl-CoA thioesterase gene family.	Histidine	103-106	bile acid-CoA:amino acid N-acyltransferase	Homo sapiens	161-167
12810727-2	2003	By use of site-directed mutagenesis and sequence comparisons, we have identified Cys-235, Asp-328, and His-362 as constituting a catalytic triad in human BACAT (hBACAT) and identifying BACAT as a member of the type I acyl-CoA thioesterase gene family.	Histidine	103-106	bile acid-CoA:amino acid N-acyltransferase	Homo sapiens	162-167
21966230-3	2009	The day 28 anti-Tat specific IgG titer with his-Tat/Ni-NP was significantly greater than that with Alum/his-Tat.	Histidine	44-47	tyrosine aminotransferase	Mus musculus	48-51
21966230-6	2009	The initial results indicated that co-immunization of mice using his-p24/his-Nef/Ni-NP induced greater antibody response compared to using Alum/his-p24/his-Nef.	Histidine	65-68	TNFAIP3 interacting protein 1	Mus musculus	77-80
23912193-3	2013	An active mature CLV3 is a tridecapeptide linked to beta-L-Araf-(1 2)-beta-L-Araf-(1 2)-beta-L-Araf at a Hyp residue in the center of the peptide sequence such as Arg-Thr-Val-Hyp-Ser-Gly-Hyp(L-Arafn)-Asp-Pro-Leu-His-His-His (n = 3).	Histidine	216-219	alpha-L-arabinofuranosidase 1	Arabidopsis thaliana	77-81
23912193-3	2013	An active mature CLV3 is a tridecapeptide linked to beta-L-Araf-(1 2)-beta-L-Araf-(1 2)-beta-L-Araf at a Hyp residue in the center of the peptide sequence such as Arg-Thr-Val-Hyp-Ser-Gly-Hyp(L-Arafn)-Asp-Pro-Leu-His-His-His (n = 3).	Histidine	216-219	alpha-L-arabinofuranosidase 1	Arabidopsis thaliana	77-81
23818523-8	2013	However, PEDF-R polypeptides without the His(203)-Leu(232) region lost the PEDF affinity that stimulated their enzymatic activity.	Histidine	41-44	serpin family F member 1	Homo sapiens	9-13
21966230-6	2009	The initial results indicated that co-immunization of mice using his-p24/his-Nef/Ni-NP induced greater antibody response compared to using Alum/his-p24/his-Nef.	Histidine	65-68	TNFAIP3 interacting protein 1	Mus musculus	156-159
21966230-6	2009	The initial results indicated that co-immunization of mice using his-p24/his-Nef/Ni-NP induced greater antibody response compared to using Alum/his-p24/his-Nef.	Histidine	73-76	TNFAIP3 interacting protein 1	Mus musculus	77-80
21966230-6	2009	The initial results indicated that co-immunization of mice using his-p24/his-Nef/Ni-NP induced greater antibody response compared to using Alum/his-p24/his-Nef.	Histidine	73-76	TNFAIP3 interacting protein 1	Mus musculus	156-159
21966230-6	2009	The initial results indicated that co-immunization of mice using his-p24/his-Nef/Ni-NP induced greater antibody response compared to using Alum/his-p24/his-Nef.	Histidine	73-76	TNFAIP3 interacting protein 1	Mus musculus	77-80
21966230-6	2009	The initial results indicated that co-immunization of mice using his-p24/his-Nef/Ni-NP induced greater antibody response compared to using Alum/his-p24/his-Nef.	Histidine	73-76	TNFAIP3 interacting protein 1	Mus musculus	156-159
21966230-6	2009	The initial results indicated that co-immunization of mice using his-p24/his-Nef/Ni-NP induced greater antibody response compared to using Alum/his-p24/his-Nef.	Histidine	73-76	TNFAIP3 interacting protein 1	Mus musculus	77-80
21966230-6	2009	The initial results indicated that co-immunization of mice using his-p24/his-Nef/Ni-NP induced greater antibody response compared to using Alum/his-p24/his-Nef.	Histidine	73-76	TNFAIP3 interacting protein 1	Mus musculus	156-159
12860998-5	2003	Mutation of histidine residues 19 and 22 to leucine on the p21-binding domain of Pak5 completely abolished the binding of Cdc42 and the Cdc42-mediated autophosphorylation.	Histidine	12-21	cell division cycle 42	Homo sapiens	122-127
12860998-5	2003	Mutation of histidine residues 19 and 22 to leucine on the p21-binding domain of Pak5 completely abolished the binding of Cdc42 and the Cdc42-mediated autophosphorylation.	Histidine	12-21	cell division cycle 42	Homo sapiens	136-141
14499900-4	2003	We also show that the ionization state of a network of five histidines, His108, His119, His121, His132 and His137, and two aspartic acids Asp141 and Asp144, contributes approximately 12 kcal/mol to the stability of the catalytic site of GART, out of a total stability of 16 kcal/mol of the whole enzyme.	Histidine	60-70	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	Homo sapiens	237-241
12944466-7	2003	The interaction involves the I-mfa domain of HIC and the regulatory histidine-rich region of cyclin T1.	Histidine	68-77	MyoD family inhibitor	Homo sapiens	29-34
23947369-2	2013	The Fhit protein is a member of the ubiquitous histidine triad proteins which hydrolyze dinucleoside polyphosphates such as Ap3A.	Histidine	47-56	fragile histidine triad diadenosine triphosphatase	Homo sapiens	4-8
12893290-6	2003	Such increases, however, were markedly or completely abolished in mutants that had a substitution (Ala, Cys, Asp, or His) on the serine residue in the GXSXG motif, providing direct evidence that NRE is a serine hydrolase.	Histidine	117-120	patatin-like phospholipase domain containing 7	Rattus norvegicus	195-198
19473029-5	2009	Substitution of His in MTII also provided functional selectivity for the hMC3R or the hMC4R.	Histidine	16-19	melanocortin 3 receptor	Homo sapiens	73-78
23874440-9	2013	Histidine mimicked the effect of protease inhibitors causing an almost complete nNOS inhibition in cells incubated additionally in lysine that depletes the exchangeable arginine pool.	Histidine	0-9	nitric oxide synthase 1	Homo sapiens	80-84
19346561-2	2009	Like other alpha-oxamine synthase subfamily enzymes, SPT is different from most of the fold type I enzymes in that its re face of the PLP-Lys aldimine is occupied by a His residue (His(159)) instead of an aromatic amino acid residue.	Histidine	168-171	pyridoxal phosphatase	Homo sapiens	134-137
19346561-2	2009	Like other alpha-oxamine synthase subfamily enzymes, SPT is different from most of the fold type I enzymes in that its re face of the PLP-Lys aldimine is occupied by a His residue (His(159)) instead of an aromatic amino acid residue.	Histidine	181-184	pyridoxal phosphatase	Homo sapiens	134-137
19578286-1	2009	The fragile histidine triad (FHIT) gene is a tumor-associated gene, and aberrant FHIT gene and protein expression have been described in many types of human tumors.	Histidine	12-21	fragile histidine triad diadenosine triphosphatase	Homo sapiens	29-33
12754209-5	2003	MKP3 activation requires residues Tyr-111, Thr-116, Leu-119, Lys-149, Arg-189, Trp-190, Glu-218, Arg-223, Lys-229, and His-230 in the ERK2 substrate-binding region, located distal to the common docking site.	Histidine	119-122	dual specificity phosphatase 6	Homo sapiens	0-4
19578286-1	2009	The fragile histidine triad (FHIT) gene is a tumor-associated gene, and aberrant FHIT gene and protein expression have been described in many types of human tumors.	Histidine	12-21	fragile histidine triad diadenosine triphosphatase	Homo sapiens	81-85
12941880-1	2003	The Arabidopsis thaliana AHK4 histidine kinase (also known as CRE1 or WOL) acts as a cytokinin signal transducer, presumably, in concert with downstream components, such as histidine-containing phosphotransfer factors (AHPs) and response regulators (ARRs), through the histidine-to-aspartate (His--&gt;Asp) phosphorelay.	Histidine	30-39	CHASE domain containing histidine kinase protein	Arabidopsis thaliana	25-29
23592749-0	2013	Histidines in potential substrate recognition sites affect thyroid hormone transport by monocarboxylate transporter 8 (MCT8).	Histidine	0-10	solute carrier family 16 member 2	Canis lupus familiaris	88-117
12941880-1	2003	The Arabidopsis thaliana AHK4 histidine kinase (also known as CRE1 or WOL) acts as a cytokinin signal transducer, presumably, in concert with downstream components, such as histidine-containing phosphotransfer factors (AHPs) and response regulators (ARRs), through the histidine-to-aspartate (His--&gt;Asp) phosphorelay.	Histidine	30-39	CHASE domain containing histidine kinase protein	Arabidopsis thaliana	62-66
12941880-1	2003	The Arabidopsis thaliana AHK4 histidine kinase (also known as CRE1 or WOL) acts as a cytokinin signal transducer, presumably, in concert with downstream components, such as histidine-containing phosphotransfer factors (AHPs) and response regulators (ARRs), through the histidine-to-aspartate (His--&gt;Asp) phosphorelay.	Histidine	30-39	CHASE domain containing histidine kinase protein	Arabidopsis thaliana	70-73
12941880-1	2003	The Arabidopsis thaliana AHK4 histidine kinase (also known as CRE1 or WOL) acts as a cytokinin signal transducer, presumably, in concert with downstream components, such as histidine-containing phosphotransfer factors (AHPs) and response regulators (ARRs), through the histidine-to-aspartate (His--&gt;Asp) phosphorelay.	Histidine	173-182	CHASE domain containing histidine kinase protein	Arabidopsis thaliana	25-29
12941880-1	2003	The Arabidopsis thaliana AHK4 histidine kinase (also known as CRE1 or WOL) acts as a cytokinin signal transducer, presumably, in concert with downstream components, such as histidine-containing phosphotransfer factors (AHPs) and response regulators (ARRs), through the histidine-to-aspartate (His--&gt;Asp) phosphorelay.	Histidine	173-182	CHASE domain containing histidine kinase protein	Arabidopsis thaliana	62-66
12941880-1	2003	The Arabidopsis thaliana AHK4 histidine kinase (also known as CRE1 or WOL) acts as a cytokinin signal transducer, presumably, in concert with downstream components, such as histidine-containing phosphotransfer factors (AHPs) and response regulators (ARRs), through the histidine-to-aspartate (His--&gt;Asp) phosphorelay.	Histidine	173-182	CHASE domain containing histidine kinase protein	Arabidopsis thaliana	70-73
12941880-1	2003	The Arabidopsis thaliana AHK4 histidine kinase (also known as CRE1 or WOL) acts as a cytokinin signal transducer, presumably, in concert with downstream components, such as histidine-containing phosphotransfer factors (AHPs) and response regulators (ARRs), through the histidine-to-aspartate (His--&gt;Asp) phosphorelay.	Histidine	293-296	CHASE domain containing histidine kinase protein	Arabidopsis thaliana	25-29
12941880-1	2003	The Arabidopsis thaliana AHK4 histidine kinase (also known as CRE1 or WOL) acts as a cytokinin signal transducer, presumably, in concert with downstream components, such as histidine-containing phosphotransfer factors (AHPs) and response regulators (ARRs), through the histidine-to-aspartate (His--&gt;Asp) phosphorelay.	Histidine	293-296	CHASE domain containing histidine kinase protein	Arabidopsis thaliana	62-66
12941880-1	2003	The Arabidopsis thaliana AHK4 histidine kinase (also known as CRE1 or WOL) acts as a cytokinin signal transducer, presumably, in concert with downstream components, such as histidine-containing phosphotransfer factors (AHPs) and response regulators (ARRs), through the histidine-to-aspartate (His--&gt;Asp) phosphorelay.	Histidine	293-296	CHASE domain containing histidine kinase protein	Arabidopsis thaliana	70-73
19402665-2	2009	These compounds were examined for affinity and ATPase stimulation in isolated MDR3 CL P-gp and human P-gp-His(10), for their ability to promote uptake of calcein AM and vinblastine in multidrug-resistant MDCKII-MDR1 cells, and for transport in monolayers of MDCKII-MDR1 cells.	Histidine	105-109	dynein axonemal heavy chain 8	Homo sapiens	47-53
12941880-6	2003	These results support the view that ARR15 acts as a repressor that mediates a negative feedback loop in the cytokinin and AHK4-mediated His--&gt;Asp phosphorelay.	Histidine	136-139	CHASE domain containing histidine kinase protein	Arabidopsis thaliana	122-126
23592749-0	2013	Histidines in potential substrate recognition sites affect thyroid hormone transport by monocarboxylate transporter 8 (MCT8).	Histidine	0-10	solute carrier family 16 member 2	Canis lupus familiaris	119-123
23193992-7	2013	Application of 3-methylcholanthrene, the AHR agonist, enhances BRET signals in cells co-expressing AHR-RL, AIP-His, P23-His and ARNT-YFP (AAPA cells), while suppressing BRET signals in cells co-expressing AHR-RL, AIP-His, P23-His and HSP90-YFP (AAPH cells).	Histidine	111-114	aryl hydrocarbon receptor	Homo sapiens	41-44
12865924-1	2003	Abnormalities of fragile histidine triad (FHIT) and TP53 have been found frequently in nonsmall cell lung cancers.	Histidine	25-34	fragile histidine triad diadenosine triphosphatase	Homo sapiens	42-46
19450486-3	2009	The models differed in the protonation site of His(260) in the chromophore-binding pocket such that either the delta-nitrogen (M-HSD) or the epsilon-nitrogen (M-HSE) carried a hydrogen.	Histidine	47-50	hydroxysteroid 17-beta dehydrogenase 6	Homo sapiens	161-164
23352388-3	2013	In the two ZnF proteins, an arginine that precedes the first Zn-binding histidine (RH motif) can interact with a 5mCpG or TpG dinucleotide.	Histidine	72-81	zinc finger protein 763	Homo sapiens	11-14
20716420-4	2009	Autoradiography was used for detecting the serine and histidine autophosphorylation of wild type (WT) and mutant nm23-H1 (P96S, H118F, S120G and S44A); RP-HPLC was used for detecting the NDPK activity of above proteins.	Histidine	54-63	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	113-120
12691605-7	2003	Biosynthetic analysis of pro-alpha4 and its H592R and H592K mutants in the presence or absence of the weak base, NH(4)Cl, revealed that the P6 histidine residue renders its processing by furin sensitive to cellular pH.	Histidine	143-152	furin, paired basic amino acid cleaving enzyme	Homo sapiens	187-192
12691605-9	2003	In conclusion, although the accepted furin processing motif is Arg-Xaa-(Lys/Arg)-Arg downward arrow, our data further extend it to include a regulatory histidine residue at P6 in precursors that lack a basic residue at P4.	Histidine	152-161	furin, paired basic amino acid cleaving enzyme	Homo sapiens	37-42
23617075-10	2013	The LOX-2 showed conserved six Histidine residues within a span of 520 to 590 amino acid position, a signature element for the enzyme activity.	Histidine	31-40	seed linoleate 9S-lipoxygenase-2	Glycine max	4-9
12779324-2	2003	We determined the X-ray crystal structure of a His-tagged variant of an isozyme of patatin, Pat17, to 2.2 A resolution, employing SeMet multiwavelength anomalous dispersion (MAD) phasing methods.	Histidine	47-50	Patatin-2-Kuras 1	Solanum tuberosum	83-90
19243223-3	2009	A 1.9 A crystal structure of the REV-ERBbeta LBD, in complex with the oxidized Fe(III) form of heme, shows that heme binds in a prototypical NR ligand-binding pocket, where the heme iron is coordinately bound by histidine 568 and cysteine 384.	Histidine	212-221	nuclear receptor subfamily 1 group D member 2	Homo sapiens	33-44
18983266-4	2009	We show using purified His(6)-tagged Rab11 protein and beta2AR intracellular domains fused to GST (glutathione transferase) that Rab11 interacts directly with the C-terminal tail of beta2AR, but not with the other intracellular domains of the receptor.	Histidine	23-26	RAB11A, member RAS oncogene family	Homo sapiens	129-134
12758078-0	2003	Investigation of the role of the histidine-aspartate pair in the human exonuclease III-like abasic endonuclease, Ape1.	Histidine	33-42	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	113-117
23955828-5	2013	Conserved amino acid residues involved in recognition of the 5" end of the small RNA guide strand and of the conserved (aspartate, aspartate and histidine [DDH]) motif present in their PIWI domains suggest that these four Argonaute family members may have conserved slicer activities.	Histidine	145-154	P-element induced wimpy testis	Drosophila melanogaster	185-189
12758078-4	2003	Here, we apply liquid-state NMR to investigate the role of a critical histidine residue of apurinic endonuclease 1 (Ape1), a human DNA repair enzyme that cleaves adjacent to abasic sites in DNA using one or more divalent cations and an active-site His-Asp pair.	Histidine	70-79	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	91-114
12758078-4	2003	Here, we apply liquid-state NMR to investigate the role of a critical histidine residue of apurinic endonuclease 1 (Ape1), a human DNA repair enzyme that cleaves adjacent to abasic sites in DNA using one or more divalent cations and an active-site His-Asp pair.	Histidine	70-79	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	116-120
12758078-4	2003	Here, we apply liquid-state NMR to investigate the role of a critical histidine residue of apurinic endonuclease 1 (Ape1), a human DNA repair enzyme that cleaves adjacent to abasic sites in DNA using one or more divalent cations and an active-site His-Asp pair.	Histidine	248-251	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	91-114
12758078-4	2003	Here, we apply liquid-state NMR to investigate the role of a critical histidine residue of apurinic endonuclease 1 (Ape1), a human DNA repair enzyme that cleaves adjacent to abasic sites in DNA using one or more divalent cations and an active-site His-Asp pair.	Histidine	248-251	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	116-120
12758078-5	2003	The results of these studies suggest that the Ape1 His-Asp pair does not function as either a general base catalyst or a metal ligand.	Histidine	51-54	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	46-50
18987357-2	2009	Using chimeric human-rat alphaIIbbeta3 molecules, we found that this difference in Arg-Gly-Asp-Ser (RGDS) sensitivity was the result of amino acid substitutions at residues 157, 159, and 162 in the W3:4-1 loop and an Asp-His replacement at residue 232 in the W4:4-1 loop of the alphaIIb beta propeller.	Histidine	221-224	ral guanine nucleotide dissociation stimulator	Rattus norvegicus	100-104
23293326-13	2013	Finally, discovery of this mutation indicates that in humans, the amino acid sequence His(6)Phe(7)Arg(8)Trp(9) is important not only for cAMP activation but also for ACTH binding to MC2R.	Histidine	86-89	melanocortin 2 receptor	Homo sapiens	182-186
23282202-4	2013	The longer CYC-2.2 has a lower thermodynamic stability than CYC-2.1 and lacks His residues to misligate to the heme in the protein"s denatured state.	Histidine	78-81	putative cytochrome c 2.2	Caenorhabditis elegans	11-18
12595087-7	2003	The enhancement of both rates with ATX-S10 was suppressed by 10 mM histidine.	Histidine	67-76	diencephalon/mesencephalon homeobox 1	Mus musculus	35-38
23256819-5	2013	Thus, while the modification of proteins or peptides in solution takes several days to lead to a significant amount of modification, in RHE the modifications of nucleophilic amino acids were observable already at 24 h. The chemioselectivity also appeared to be different with major modifications taking place on histidine, methionine, and cysteine residues in RHE, while on HSA, significant modifications were observed on lysine residues with the formation of methylated and dimethylated amino groups.	Histidine	312-321	factor interacting with PAPOLA and CPSF1	Homo sapiens	136-139
12574506-3	2003	Fhit, a member of branch 2 of the histidine-triad superfamily of nucleoside monophosphate hydrolases and transferases, is a diadenosine polyphosphate hydrolase, the active-site histidine of which is not required for tumor suppression.	Histidine	34-43	fragile histidine triad diadenosine triphosphatase	Homo sapiens	0-4
18782082-7	2009	In contrast with all of the other GLX2 proteins characterized, GLX2-1 contains an arginine in place of one of the metal-binding histidine residues at position 246.	Histidine	128-137	glyoxalase 2-1	Arabidopsis thaliana	63-69
19526842-2	2009	It was shown that interrelation of genotypes Arg/Arg, Arg/His and His/His in LMP2 gene polymorphisms account 42.5 %, 46.4% and 11.1% correspondingly (in control--63.9%, 28.6%, 7.5%; P = 0.001 by c2-test).	Histidine	58-61	proteasome 20S subunit beta 9	Homo sapiens	77-81
19526842-2	2009	It was shown that interrelation of genotypes Arg/Arg, Arg/His and His/His in LMP2 gene polymorphisms account 42.5 %, 46.4% and 11.1% correspondingly (in control--63.9%, 28.6%, 7.5%; P = 0.001 by c2-test).	Histidine	66-69	proteasome 20S subunit beta 9	Homo sapiens	77-81
19526842-2	2009	It was shown that interrelation of genotypes Arg/Arg, Arg/His and His/His in LMP2 gene polymorphisms account 42.5 %, 46.4% and 11.1% correspondingly (in control--63.9%, 28.6%, 7.5%; P = 0.001 by c2-test).	Histidine	66-69	proteasome 20S subunit beta 9	Homo sapiens	77-81
23276281-4	2013	We demonstrate that the unusual His(4) motif (site 2) formed at the S100A8/S100A9 dimer interface is the site of high-affinity Mn(II) coordination.	Histidine	32-35	S100 calcium binding protein A8	Homo sapiens	68-74
12515557-1	2003	Nup475 (also known as tristetraprolin and TIS11) includes two zinc-binding domains of the form Cys-X8-Cys-X5-Cys-X3-His.	Histidine	116-119	ZFP36 ring finger protein	Homo sapiens	0-6
12515557-1	2003	Nup475 (also known as tristetraprolin and TIS11) includes two zinc-binding domains of the form Cys-X8-Cys-X5-Cys-X3-His.	Histidine	116-119	ZFP36 ring finger protein	Homo sapiens	22-37
23724516-0	2013	Loss of heterozygosity in the fragile histidine triad (FHIT) locus and expression analysis of FHIT protein in patients with breast disorders.	Histidine	38-47	fragile histidine triad diadenosine triphosphatase	Homo sapiens	55-59
12515557-1	2003	Nup475 (also known as tristetraprolin and TIS11) includes two zinc-binding domains of the form Cys-X8-Cys-X5-Cys-X3-His.	Histidine	116-119	ZFP36 ring finger protein	Homo sapiens	42-47
12765788-1	2003	Earlier work described the cloning of a gene from murine 3T3 cells encoding a cytoplasmic protein Chrp containing a cysteine- and histidine-rich motif characteristic of Zn-finger proteins.	Histidine	130-139	cysteine and histidine rich 1	Mus musculus	98-102
19672046-11	2009	We conclude that elevated amounts of His-15-phosphorylated HPr, formed in the hprK mutant, are responsible for its growth defect.	Histidine	37-40	haptoglobin-related protein	Homo sapiens	59-62
18829452-7	2008	Here we report on the interactions of RhoA, Rac1, and Cdc42 with mDia1 and an mDia1 mutant (mDia(N)-Thr-Ser-His (TSH)), which based on structural information should mimic mDia2 and -3.	Histidine	108-111	cell division cycle 42	Homo sapiens	54-59
18829452-7	2008	Here we report on the interactions of RhoA, Rac1, and Cdc42 with mDia1 and an mDia1 mutant (mDia(N)-Thr-Ser-His (TSH)), which based on structural information should mimic mDia2 and -3.	Histidine	108-111	diaphanous related formin 1	Mus musculus	78-83
18829452-10	2008	The triple N motif of mDia1 allows tight interaction with Rho because of the presence of Phe-106, whereas the corresponding His-104 in Rac and Cdc42 forms a complementary interface with the TSH motif in mDia2/3.	Histidine	124-127	diaphanous related formin 1	Mus musculus	22-27
18829452-10	2008	The triple N motif of mDia1 allows tight interaction with Rho because of the presence of Phe-106, whereas the corresponding His-104 in Rac and Cdc42 forms a complementary interface with the TSH motif in mDia2/3.	Histidine	124-127	cell division cycle 42	Homo sapiens	143-148
23724516-1	2013	PURPOSE OF INVESTIGATION: The fragile histidine triad (FHIT) gene is a tumor suppressor frequently inactivated in various types of tumors.	Histidine	38-47	fragile histidine triad diadenosine triphosphatase	Homo sapiens	55-59
18829452-10	2008	The triple N motif of mDia1 allows tight interaction with Rho because of the presence of Phe-106, whereas the corresponding His-104 in Rac and Cdc42 forms a complementary interface with the TSH motif in mDia2/3.	Histidine	124-127	diaphanous related formin 3	Mus musculus	203-210
12457722-2	2003	Fragile histidine triad (FHIT) gene is located at 3p14.2 encompassing a common fragile site, and is identified as a tumor suppressor gene.	Histidine	8-17	fragile histidine triad diadenosine triphosphatase	Homo sapiens	25-29
23724516-8	2013	The changes in the locus of the FHIT gene occur with greater frequency in the coded region of the gene, principally near exons 5 and 8, where the FRA3B site and the histidine triad respectively are found.	Histidine	165-174	fragile histidine triad diadenosine triphosphatase	Homo sapiens	32-36
12355215-1	2002	BACKGROUND AND AIMS: The fragile histidine triad (FHIT) gene, which is frequently lost in many cancers, has been identified as a candidate tumor suppressor gene at chromosome 3p locus 14.2.	Histidine	33-42	fragile histidine triad diadenosine triphosphatase	Homo sapiens	50-54
12381809-5	2002	To examine physical association between Kir2.1 and Kir2.4, Cos-7 cells were co-transfected with a His(6)-tagged Kir2.1 subunit (Kir2.1-His(6)) and a FLAG-tagged Kir2.4 subunit (Kir2.4-FLAG).	Histidine	98-101	potassium inwardly rectifying channel subfamily J member 2 L homeolog	Xenopus laevis	112-118
12381809-5	2002	To examine physical association between Kir2.1 and Kir2.4, Cos-7 cells were co-transfected with a His(6)-tagged Kir2.1 subunit (Kir2.1-His(6)) and a FLAG-tagged Kir2.4 subunit (Kir2.4-FLAG).	Histidine	98-101	potassium inwardly rectifying channel subfamily J member 2 L homeolog	Xenopus laevis	112-118
12381809-6	2002	After pulldown with a His(6)-binding resin, Kir2.4-FLAG could be detected in the eluted cell lysate by Western blotting, indicating co-assembly of Kir2.1-His(6) and Kir2.4-FLAG.	Histidine	22-25	potassium inwardly rectifying channel subfamily J member 2 L homeolog	Xenopus laevis	147-153
12381809-6	2002	After pulldown with a His(6)-binding resin, Kir2.4-FLAG could be detected in the eluted cell lysate by Western blotting, indicating co-assembly of Kir2.1-His(6) and Kir2.4-FLAG.	Histidine	154-157	potassium inwardly rectifying channel subfamily J member 2 L homeolog	Xenopus laevis	147-153
12441142-5	2002	In this study we describe abrogation of IL-7 driven proliferation and attenuated phosphotyrosine signaling by IL-7(143) (Trp-Ala) and IL-7(143) (Trp-His) in IL-7R expressing T and B leukemia cells.	Histidine	149-152	interleukin 7 receptor	Homo sapiens	157-162
19649236-3	2002	Direct sequencing of calsequestrin 2 (CASQ2), a candidate gene from within the linkage interval, revealed a negatively charged aspartic acid change to a positively charged histidine at position 307 of the protein.	Histidine	172-181	calsequestrin 2	Homo sapiens	21-36
19649236-3	2002	Direct sequencing of calsequestrin 2 (CASQ2), a candidate gene from within the linkage interval, revealed a negatively charged aspartic acid change to a positively charged histidine at position 307 of the protein.	Histidine	172-181	calsequestrin 2	Homo sapiens	38-43
12177781-1	2002	The Fragile Histidine Triad gene, encompassing the FRA3B fragile site at chromosome 3p14.2, is a candidate tumour suppressor gene involved in multiple tumour types including colorectal carcinomas.	Histidine	12-21	fragile histidine triad diadenosine triphosphatase	Homo sapiens	51-56
11937506-7	2002	The abolishment of the Abf1p-binding site within the HIS7 promoter significantly enhances transcriptional interference, resulting in a histidine auxotrophic strain.	Histidine	135-144	imidazoleglycerol-phosphate synthase	Saccharomyces cerevisiae S288C	53-57
12023363-7	2002	The codons determining the isotype, Asp(1054), Leu(1101), Ser(1102), Ile(1105) and His(1106), were characteristic of C4B gene, whereas the polymorphic sites in exon and intron 28 were indicative of C4A3a sequence.	Histidine	83-86	complement C4B (Chido blood group)	Homo sapiens	117-120
11912212-3	2002	The PIMT binding sites on CBP and p300 are located in the cysteine-histidine-rich C/H1 and C/H3 domains, and the PIMT binding site on PBP is in the region encompassing amino acids 1101-1560.	Histidine	67-76	E1A binding protein p300	Homo sapiens	34-38
12048684-1	2002	OBJECTIVE: To explore the role of fragile histidine triad(FHIT) gene in the proliferation, apoptosis and tumorigenesis of human lung cancer cells.	Histidine	42-51	fragile histidine triad diadenosine triphosphatase	Homo sapiens	58-62
11850428-7	2002	The mutation of MBP-A His(189) to its MBP-C equivalent, valine, causes Man alpha 1-3Man to bind in a mixture of orientations.	Histidine	22-25	myelin basic protein	Homo sapiens	16-19
12027899-0	2002	Histidine mutagenesis of Arabidopsis thaliana pyruvate dehydrogenase kinase.	Histidine	0-9	pyruvate dehydrogenase kinase	Arabidopsis thaliana	46-75
12027899-3	2002	This seeming contradiction might be resolved if the PDK-catalyzed reaction employed a phospho-His intermediate.	Histidine	94-97	pyruvate dehydrogenase kinase	Arabidopsis thaliana	52-55
11955062-3	2002	Mutagenesis revealed that part of the bias to initiate with GTP is due to an interaction between histidine 784 and the 2-amino group of a guanosine bound in the initiating triphosphate position.	Histidine	97-106	mitochondrial ribosome associated GTPase 1	Homo sapiens	60-63
11959990-2	2002	We report the solution structure of the cysteine/histidine-rich 1 (CH1) domain of p300 bound to the C-terminal transactivation domain of HIF-1 alpha.	Histidine	49-58	E1A binding protein p300	Homo sapiens	82-86
12455952-2	2002	Sln1p consists of a sensor kinase module that undergoes histidine autophosphorylation and a receiver module that autocatalytically transfers the phosphoryl group from histidine to aspartate.	Histidine	56-65	histidine kinase	Saccharomyces cerevisiae S288C	0-5
12455952-2	2002	Sln1p consists of a sensor kinase module that undergoes histidine autophosphorylation and a receiver module that autocatalytically transfers the phosphoryl group from histidine to aspartate.	Histidine	167-176	histidine kinase	Saccharomyces cerevisiae S288C	0-5
11744733-5	2002	The interaction occurs between the cysteine-histidine-rich domain 1 of p300 and the carboxyl terminus of CITED4.	Histidine	44-53	E1A binding protein p300	Homo sapiens	71-75
11744733-5	2002	The interaction occurs between the cysteine-histidine-rich domain 1 of p300 and the carboxyl terminus of CITED4.	Histidine	44-53	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4	Homo sapiens	105-111
11858723-1	2002	Human fibroblast activation protein (FAP), an integral membrane serine protease, was produced in insect cells as a hexa-His-tagged protein using a recombinant baculovirus expression system.	Histidine	120-123	fibroblast activation protein alpha	Homo sapiens	6-35
11858723-1	2002	Human fibroblast activation protein (FAP), an integral membrane serine protease, was produced in insect cells as a hexa-His-tagged protein using a recombinant baculovirus expression system.	Histidine	120-123	fibroblast activation protein alpha	Homo sapiens	37-40
11858723-2	2002	Two isoforms of FAP, glycosylated and nonglycosylated, were identified by Western blotting using an anti-His-tag antibody and separated by lectin chromatography.	Histidine	105-108	fibroblast activation protein alpha	Homo sapiens	16-19
11841228-5	2002	Since crystallographic studies have shown that the 5-coordinate nitrosyl complex of cytochrome c" binds NO to the proximal (rather than distal) face of the heme, the NO dependence of the 6- to 5-coordinate NO conversion supports a mechanism in which the weakened His ligand, as well as the distally bound NO, is displaced by a second NO molecule which attacks and is retained in the proximal coordination position.	Histidine	263-266	D-alanyl-D-alanine carboxypeptidase	Achromobacter xylosoxidans	84-96
11841228-6	2002	The fact that a dependent 6- to 5-coordinate nitrosyl conversion has been previously reported for soluble guanylate cyclase suggests that the mechanism of Fe-His bond cleavage may be similar to that of cytochrome c" and strengthens the recent proposal that both proteins exhibit proximal NO binding in their 5-coordinate nitrosyl adducts.	Histidine	158-161	D-alanyl-D-alanine carboxypeptidase	Achromobacter xylosoxidans	202-214
11782371-5	2002	The rescue function mapped to the cysteine-histidine rich domain CH3, a region of p300/CBP that we found to interact directly with the conserved COOH-terminal activation domain (AF-2) of ER-alpha.	Histidine	43-52	E1A binding protein p300	Homo sapiens	82-86
11840265-7	2002	Moreover, we found that normal human stem cells treated with high doses of His-TRAIL maintain a repopulating potential when transplanted into NOD/SCID mice.	Histidine	75-78	atrophin 1	Homo sapiens	142-145
12401339-4	2002	Chronic lithium effect on TRH receptor binding studies: The effect of 1 and 2 weeks of dietary lithium on [(3)H]3-Me-His-TRH binding to plasma membranes of nucleus accumbens, amygdala and pituitary of young adult male Wistar and the endogenously "depressed" Wistar Kyoto (WKY) rats was measured by the method of Burt and Taylor [Burt, D.R., Taylor, R.L., Endocrinology 106 (1980) 1416-1423].	Histidine	117-120	thyrotropin releasing hormone	Rattus norvegicus	121-124
11752426-8	2001	One of the Janus kinases, human TYK2, has an SH2 domain that contains a histidine instead of the conserved arginine at the key phosphotyrosine-binding position, betaB5.	Histidine	72-81	tyrosine kinase 2	Homo sapiens	32-36
11752426-9	2001	Calculations of the pK(a) values of the betaB5 arginines in a number of SH2 domains and of the betaB5 histidine in a homology model of TYK2 suggest that this histidine is likely to be neutral around pH 7, thus indicating that it may have lost the ability to bind phosphotyrosine.	Histidine	102-111	tyrosine kinase 2	Homo sapiens	135-139
11752426-9	2001	Calculations of the pK(a) values of the betaB5 arginines in a number of SH2 domains and of the betaB5 histidine in a homology model of TYK2 suggest that this histidine is likely to be neutral around pH 7, thus indicating that it may have lost the ability to bind phosphotyrosine.	Histidine	158-167	tyrosine kinase 2	Homo sapiens	135-139
11553629-0	2001	Structural model of the catalytic core of carnitine palmitoyltransferase I and carnitine octanoyltransferase (COT): mutation of CPT I histidine 473 and alanine 381 and COT alanine 238 impairs the catalytic activity.	Histidine	134-143	carnitine palmitoyltransferase 1B	Rattus norvegicus	42-74
11553629-0	2001	Structural model of the catalytic core of carnitine palmitoyltransferase I and carnitine octanoyltransferase (COT): mutation of CPT I histidine 473 and alanine 381 and COT alanine 238 impairs the catalytic activity.	Histidine	134-143	carnitine O-octanoyltransferase	Rattus norvegicus	79-108
11553629-0	2001	Structural model of the catalytic core of carnitine palmitoyltransferase I and carnitine octanoyltransferase (COT): mutation of CPT I histidine 473 and alanine 381 and COT alanine 238 impairs the catalytic activity.	Histidine	134-143	carnitine O-octanoyltransferase	Rattus norvegicus	110-113
11553629-0	2001	Structural model of the catalytic core of carnitine palmitoyltransferase I and carnitine octanoyltransferase (COT): mutation of CPT I histidine 473 and alanine 381 and COT alanine 238 impairs the catalytic activity.	Histidine	134-143	carnitine palmitoyltransferase 1B	Rattus norvegicus	128-133
11745997-4	2001	Sequencing analysis of the TNSALP gene showed two heterozygous mutations, 648+1A, a mutation affecting the donor splice site in exon 6, and N400S, a novel missense mutation in exon 11, located near the active site and very close to histidins 364 and 437, two crucial residues of the active site.	Histidine	232-241	alkaline phosphatase, biomineralization associated	Homo sapiens	27-33
11489879-2	2001	In an effort to identify amino acid residues near the phylloquinone binding sites, all tryptophans and histidines that are conserved between PsaA and PsaB in the region of the 10th and 11th transmembrane alpha-helices were mutated in Chlamydomonas reinhardtii.	Histidine	103-113	photosystem I P700 chlorophyll a apoprotein A1	Chlamydomonas reinhardtii	141-145
18773979-5	2008	In the first case we presumably mimic binding of the ternary complex EF-Tu.GTP.aa-tRNA to the ribosome and allow the histidine (His85) side chain of the protein to approach the reaction active site.	Histidine	117-126	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	69-74
18773979-6	2008	In the second case, corresponding to the GTP hydrolysis by EF-Tu alone, the side chain of His85 stays away from the active site, and the chemical reaction GTP+H(2)O--&gt;GDP+Pi proceeds without participation of the histidine but through water molecules.	Histidine	215-224	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	59-64
18780819-11	2008	Our analysis also reveals that a histidine residue (His124), highly conserved in the DEDDh family, is involved in the activity of TREX1, as confirmed by mutational studies.	Histidine	33-42	three prime repair exonuclease 1	Homo sapiens	130-135
20641607-4	2004	Neuromedin B (NMB) is a peptide of 32 amino acids from porcine spinal cords with Gly-His-Phe-Met at its C-terminus.	Histidine	85-88	neuromedin B	Homo sapiens	0-12
20641607-4	2004	Neuromedin B (NMB) is a peptide of 32 amino acids from porcine spinal cords with Gly-His-Phe-Met at its C-terminus.	Histidine	85-88	neuromedin B	Homo sapiens	14-17
18635554-0	2008	Single histidine-substituted cardiac troponin I confers protection from age-related systolic and diastolic dysfunction.	Histidine	7-16	troponin I, cardiac 3	Mus musculus	29-47
18635554-4	2008	METHODS AND RESULTS: To address this, we investigated transgenic (Tg) mice expressing a histidine-substituted form of adult cardiac troponin I (cTnI A164H), which increases myofilament calcium sensitivity in a pH-dependent manner.	Histidine	88-97	troponin I, cardiac 3	Mus musculus	124-142
18635554-4	2008	METHODS AND RESULTS: To address this, we investigated transgenic (Tg) mice expressing a histidine-substituted form of adult cardiac troponin I (cTnI A164H), which increases myofilament calcium sensitivity in a pH-dependent manner.	Histidine	88-97	troponin I, cardiac 3	Mus musculus	144-148
18635554-8	2008	CONCLUSION: This study shows that increasing myofilament function by means of a pH-responsive histidine button engineered into cTnI results in enhanced baseline heart function in Tg mice over their lifetime, and during acute hypoxia improves survival in aged mice by maintaining cardiac contractility.	Histidine	94-103	troponin I, cardiac 3	Mus musculus	127-131
18694821-2	2008	PLC-beta(1) mutational analysis revealed the importance of His(331) and His(378) for the catalysis.	Histidine	59-62	phospholipase C, beta 1	Mus musculus	0-10
18694821-2	2008	PLC-beta(1) mutational analysis revealed the importance of His(331) and His(378) for the catalysis.	Histidine	72-75	phospholipase C, beta 1	Mus musculus	0-10
18830969-4	2008	Plasmid pCMVbeta, expressing beta-galactosidase, was encapsulated with cationic liposome, and then the histidine-tagged preS domain of hepatitis B virus was coated on the surface of liposome/DNA to form preS/liposome/ DNA VLP.	Histidine	103-112	galactosidase beta 1	Homo sapiens	29-47
18665614-7	2008	The p K a values of three of four histidine residues (His12, -105, and -119) in RNase A were successfully determined by this method and were in good agreement with those determined by (1)H NMR and hydrogen-tritium exchange methods.	Histidine	34-43	ribonuclease A family member 1, pancreatic	Homo sapiens	80-87
18214462-1	2008	The Kv1.3 channel inactivates via the P/C-type mechanism, which is influenced by a histidine residue in the pore region (H399, equivalent of Shaker 449).	Histidine	83-92	potassium voltage-gated channel subfamily A member 3	Homo sapiens	4-9
18539702-4	2008	First, the absence of efficacy for PTHrP at PTH-2R is due to the presence of His-5 in PTHrP (Ile-5 in PTH), which interacts with the receptor"s juxtamembrane domain.	Histidine	77-80	parathyroid hormone like hormone	Homo sapiens	86-91
18544529-0	2008	Modulation of double-stranded RNA recognition by the N-terminal histidine-rich region of the human toll-like receptor 3.	Histidine	64-73	toll like receptor 3	Homo sapiens	99-119
18544529-6	2008	To elucidate the pH-dependent binding mechanism of TLR3 at the structural level, we focused on three highly conserved histidine residues clustered at the N-terminal region of the TLR3 ECD: His39 in the N-cap region, His60 in LRR1, and His108 in LRR3.	Histidine	118-127	toll like receptor 3	Homo sapiens	51-55
18544529-6	2008	To elucidate the pH-dependent binding mechanism of TLR3 at the structural level, we focused on three highly conserved histidine residues clustered at the N-terminal region of the TLR3 ECD: His39 in the N-cap region, His60 in LRR1, and His108 in LRR3.	Histidine	118-127	toll like receptor 3	Homo sapiens	179-183
18482847-4	2008	The assembled fragment was introduced into P. pastoris expression vector pPIC9K and the resultant plasmid pPIC9K-zbtb7a-his(6) was transformed into the P. pastoris strain GS115 by electroporation.	Histidine	120-123	zinc finger and BTB domain containing 7A	Homo sapiens	113-119
18474604-7	2008	A single amino acid substitution of Asp at residue position 218 of TRAIL to His or Tyr was predicted to have a favorable effect on DR4 binding specificity.	Histidine	76-79	TNF receptor superfamily member 10a	Homo sapiens	131-134
18445588-4	2008	His --&gt; Glu/Asp mutations of the active site histidines designed to mimic the phosphorylated states reveal binding equilibria that favor phosphoryl transfer from EIN to HPr.	Histidine	0-3	haptoglobin-related protein	Homo sapiens	172-175
18445588-4	2008	His --&gt; Glu/Asp mutations of the active site histidines designed to mimic the phosphorylated states reveal binding equilibria that favor phosphoryl transfer from EIN to HPr.	Histidine	48-58	haptoglobin-related protein	Homo sapiens	172-175
18491920-6	2008	The tail histidine residues, along with two previously identified lysine residues, account for a major part of the polyelectrolyte contribution to binding and for the nonspecific affinity of Mbp1 for DNA.	Histidine	9-18	transcription factor MBP1	Saccharomyces cerevisiae S288C	191-195
18384742-2	2008	Fluorescence polarization studies presented here demonstrate a specific interaction of ETR1 with the histidine-containing transfer protein AHP1, supporting the idea that a phosphorelay module is involved in ethylene signaling.	Histidine	101-110	CUGBP Elav-like family member 3	Homo sapiens	87-91
18561331-10	2008	Among the radical scavengers, histidine significantly inhibited the cytotoxic activity of H2-a, suggesting the involvement of singlet oxygen in the cytotoxicity.	Histidine	30-39	H2A clustered histone 18	Homo sapiens	90-94
18357366-1	2008	The fragile histidine triad (FHIT), frequently lost in many cancers, was identified as a candidate tumor suppressor gene at chromosome 3p locus 14.2.	Histidine	12-21	fragile histidine triad diadenosine triphosphatase	Homo sapiens	29-33
18178100-2	2008	In this study, a new mouse recombinant ACBP was produced by insertion of a histidine (his) tag at the C-terminus to allow efficient purification by Ni-affinity chromatography.	Histidine	75-84	diazepam binding inhibitor	Mus musculus	39-43
18178100-2	2008	In this study, a new mouse recombinant ACBP was produced by insertion of a histidine (his) tag at the C-terminus to allow efficient purification by Ni-affinity chromatography.	Histidine	4-7	diazepam binding inhibitor	Mus musculus	39-43
18178100-5	2008	His-ACBP bound the naturally occurring fluorescent cis-parinaroyl-CoA with very high affinity (K(d)=2.15 nM), but exhibited no affinity for non-esterified cis-parinaric acid.	Histidine	0-3	diazepam binding inhibitor	Mus musculus	4-8
18178100-6	2008	To determine if the presence of the C-terminal his-tag altered ACBP interactions with other proteins, direct binding to hepatocyte nuclear factor-4alpha (HNF-4alpha), a nuclear receptor regulating transcription of genes involved in lipid metabolism, was examined.	Histidine	47-50	diazepam binding inhibitor	Mus musculus	63-67
18646716-1	2008	OBJECTIVE: To investigate the expression of nuclear factor-kappa-B (NF-KB)/P65 and fragile histidine triad (FHIT) in colorectal carcinoma and clinical significance thereof.	Histidine	91-100	fragile histidine triad diadenosine triphosphatase	Homo sapiens	108-112
18310146-9	2008	In both patients, alpha-globin gene sequencing revealed a mutation resulting in a histidine-to-aspartatic acid substitution at position alpha87.	Histidine	82-91	hemoglobin subunit alpha 2	Homo sapiens	18-30
18234162-4	2008	However, the characterisation of a novel radioligand ([(125)I-his(9)]-ghrelin), has enabled the distribution of GHS-R receptor protein to be directly demonstrated.	Histidine	62-65	growth hormone secretagogue receptor	Rattus norvegicus	112-117
11522606-4	2001	Furthermore, we have discovered that [125I-His(9)]-ghrelin density is significantly increased in atherosclerosis.	Histidine	43-46	ghrelin and obestatin prepropeptide	Rattus norvegicus	51-58
11522606-13	2001	Our results suggest that the native receptor for [125I-His(9)]-ghrelin may be widely distributed in the human cardiovascular system.	Histidine	55-58	ghrelin and obestatin prepropeptide	Rattus norvegicus	63-70
11513095-6	2001	The activity of bovine brain glyoxalase I was found to be particularly sensitive to 2,3-butanedione and diethylpyrocarbonate, selective reagents for arginine and histidine residues, respectively.	Histidine	162-171	glyoxalase I	Bos taurus	29-41
22824487-7	2012	Histidines were found to play a role in the interactions of BMP-2 with heparin; however, a pK(a) analysis suggests that histidines are likely not protonated.	Histidine	0-10	bone morphogenetic protein 2	Homo sapiens	60-65
11352900-6	2001	Two histidine residues in the extracellular loop between transmembrane domains three and four of EAAT4 appear to confer Zn(2+) inhibition of the anion conductance.	Histidine	4-13	solute carrier family 1 member 6	Homo sapiens	97-102
11415452-13	2001	Our results reveal that Cys-396 and His-480 of CopB are key residues for ATPase function, and similar roles are suggested for Cys-1000 and His-1069 of Menkes and Wilson ATPases respectively.	Histidine	36-39	dynein axonemal heavy chain 8	Homo sapiens	73-79
17872377-7	2008	Divergent residue 5 in the ligand, Ile in PTH and His in PTHrP, was identified as a key determinant of the altered receptor-interaction responses exhibited by the two peptides.	Histidine	50-53	parathyroid hormone like hormone	Homo sapiens	57-62
22981363-3	2012	The equivalent position in UGT1A4 is also known to influence enzyme activity, whilst an N-terminal domain histidine (His37 in UGT1A9) is believed to function as the catalytic base in most UGT enzymes.	Histidine	106-115	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	126-132
18077326-1	2007	The Fra3B locus on chromosome 3p14.2 targeting the fragile histidine triad (Fhit) gene represents one of the most common fragile sites of the human genome and is associated with early preneoplastic and malignant disorders in multiple human tumors.	Histidine	59-68	fragile histidine triad diadenosine triphosphatase	Homo sapiens	4-9
18077326-1	2007	The Fra3B locus on chromosome 3p14.2 targeting the fragile histidine triad (Fhit) gene represents one of the most common fragile sites of the human genome and is associated with early preneoplastic and malignant disorders in multiple human tumors.	Histidine	59-68	fragile histidine triad diadenosine triphosphatase	Homo sapiens	76-80
11406559-1	2001	The fragile histidine triad (FHIT) gene is a tumor suppressor gene that is altered by deletion in a large fraction of human tumors, including pancreatic cancer.	Histidine	12-21	fragile histidine triad diadenosine triphosphatase	Homo sapiens	29-33
22893680-7	2012	Expression of the CaM isoform Gly-Ser-His-CaM (GSH-CaM), which has much higher binding affinity than wild-type CaM for RyR1, restored normal CaM binding to RyR2 in both SR and myocytes of failing hearts.	Histidine	38-41	calmodulin-2	Canis lupus familiaris	18-21
11337267-5	2001	Recently, the human fragile histidine triad (FHIT) gene was isolated from this region, abnormalities of which have been found at high frequencies in several types of human cancers.	Histidine	28-37	fragile histidine triad diadenosine triphosphatase	Homo sapiens	45-49
20641798-8	2004	alpha-MSH (Ac-Ser(1)-Tyr(2)-Ser(3)-Met(4)-Glu(5)-His(6)-Phe(7)-Arg(8)-Trp(9)-Gly(10)-Lys(11)-Pro(12)-Val(13)-NH2), composed of 13 amino acids, is the most potent naturally occurring melanotropic peptide (5).	Histidine	49-52	pro-opiomelanocortin-alpha	Mus musculus	0-9
22893680-7	2012	Expression of the CaM isoform Gly-Ser-His-CaM (GSH-CaM), which has much higher binding affinity than wild-type CaM for RyR1, restored normal CaM binding to RyR2 in both SR and myocytes of failing hearts.	Histidine	38-41	calmodulin-2	Canis lupus familiaris	42-45
22893680-7	2012	Expression of the CaM isoform Gly-Ser-His-CaM (GSH-CaM), which has much higher binding affinity than wild-type CaM for RyR1, restored normal CaM binding to RyR2 in both SR and myocytes of failing hearts.	Histidine	38-41	calmodulin-2	Canis lupus familiaris	42-45
11402444-1	2001	OBJECTIVE: To investigate the role of FHIT(fragile histidine triad) gene in oncogenesis and progression of human lung cancer and explore the relationship of FHIT gene expression with the proliferation and apoptosis of tumor cells.	Histidine	51-60	fragile histidine triad diadenosine triphosphatase	Homo sapiens	38-42
22893680-7	2012	Expression of the CaM isoform Gly-Ser-His-CaM (GSH-CaM), which has much higher binding affinity than wild-type CaM for RyR1, restored normal CaM binding to RyR2 in both SR and myocytes of failing hearts.	Histidine	38-41	calmodulin-2	Canis lupus familiaris	42-45
22893680-7	2012	Expression of the CaM isoform Gly-Ser-His-CaM (GSH-CaM), which has much higher binding affinity than wild-type CaM for RyR1, restored normal CaM binding to RyR2 in both SR and myocytes of failing hearts.	Histidine	38-41	calmodulin-2	Canis lupus familiaris	42-45
23021866-6	2012	Two SNPs were associated with BV as diagnosed by the Nugent score and the combined criteria: a minor allele G of rs4986790 (frequency=0.07), which encodes a His to Tyr substitution in TLR4 (HR=1.47, 95% CI 1.15-1.87) and rs187084 (frequency=0.24) on TLR9.	Histidine	157-160	toll like receptor 9	Homo sapiens	250-254
11278438-1	2001	We report a novel phospholipase A(2) (PLA(2)), group XII (GXII) PLA(2), distinct from other cysteine-rich groups with a catalytic histidine motif, by its 20-kDa size and distribution of the 14 cysteine residues within the protein.	Histidine	130-139	phospholipase A2, group XIIA	Mus musculus	47-56
11278438-1	2001	We report a novel phospholipase A(2) (PLA(2)), group XII (GXII) PLA(2), distinct from other cysteine-rich groups with a catalytic histidine motif, by its 20-kDa size and distribution of the 14 cysteine residues within the protein.	Histidine	130-139	phospholipase A2, group XIIA	Mus musculus	58-62
18039930-19	2007	Site-directed mutagenesis of these His residues results in the loss of RIDalpha-RILP interaction and RIDalpha activity in cells.	Histidine	35-38	Rab interacting lysosomal protein	Homo sapiens	80-84
22985939-9	2012	Although both His-CIPK3 and His-CIPK3T183D also accumulated in inclusion bodies, they were expressed as a single protein species.	Histidine	14-17	CBL-interacting protein kinase 3	Arabidopsis thaliana	18-23
17712558-4	2007	The O6 methylguanine DNA methyltransferase (MGMT) and fragile histidine triad (FHIT) genes are transcriptionally silenced by promoter hypermethylation in DLBCL.	Histidine	62-71	fragile histidine triad diadenosine triphosphatase	Homo sapiens	79-83
18028869-5	2007	Replacement of both Sdh3p His-106 and Sdh4p Cys-78 with alanine residues leads to an undetectable level of cytochrome b(562).	Histidine	26-29	succinate dehydrogenase cytochrome b subunit SDH3	Saccharomyces cerevisiae S288C	20-25
11278524-3	2001	We genetically modified the C terminus of hIL-18BP by appending a 15-amino acid biotinylation recognition site and a six-histidine tag and then performed site-directed mutagenesis to determine the functional epitopes that mediate efficient binding to IL-18.	Histidine	121-130	interleukin 18 binding protein	Homo sapiens	42-50
11331007-2	2001	Both catalytic sites are comprised of two histidine side chains acting as a general base-general acid pair and a phosphate-activating residue: an arginine in the case of PI-PLC and a lysine in RNase A.	Histidine	42-51	phospholipase C beta 1	Homo sapiens	170-176
11331007-2	2001	Both catalytic sites are comprised of two histidine side chains acting as a general base-general acid pair and a phosphate-activating residue: an arginine in the case of PI-PLC and a lysine in RNase A.	Histidine	42-51	ribonuclease A family member 1, pancreatic	Homo sapiens	193-200
22985939-12	2012	In addition, a 9-fold increase in kinase activity in His-CIPK3T183D was observed, indicating that Thr(183) to Asp(183) substitution in the activation loop of CIPK3 had succeeded in enhancing the kinase activity.	Histidine	53-56	CBL-interacting protein kinase 3	Arabidopsis thaliana	57-62
17539022-3	2007	Consistent with a prior report, we demonstrated by RT-PCR of RNA from lymphoblastoid cells fusion mRNAs derived from the fragile histidine triad (FHIT) at 3p14 and TRC8 at 8q24.1 in both affected siblings.	Histidine	129-138	fragile histidine triad diadenosine triphosphatase	Homo sapiens	146-150
11356174-9	2001	These results indicate that the histidine residues His-131 and His-340 are the sites responsible for the interaction of these two inhibitors, which inhibit COT by interacting with the same sites.	Histidine	32-41	carnitine O-octanoyltransferase	Rattus norvegicus	156-159
23087673-2	2012	A molecular form known as GnRH2 ([His(5) Trp(7) Tyr(8)]GnRH, also known as chicken GnRH II) is widely distributed in vertebrates except for rodents, and has recently been implicated in the regulation of feeding behavior in goldfish.	Histidine	34-37	gonadotropin-releasing hormone 2	Danio rerio	26-31
11356174-9	2001	These results indicate that the histidine residues His-131 and His-340 are the sites responsible for the interaction of these two inhibitors, which inhibit COT by interacting with the same sites.	Histidine	51-54	carnitine O-octanoyltransferase	Rattus norvegicus	156-159
11356174-9	2001	These results indicate that the histidine residues His-131 and His-340 are the sites responsible for the interaction of these two inhibitors, which inhibit COT by interacting with the same sites.	Histidine	63-66	carnitine O-octanoyltransferase	Rattus norvegicus	156-159
22743102-4	2012	Previous studies identified a histidine residue (His69) that functions as a pH sensor in the propeptide of furin (PRO(FUR)), which regulates furin activation at pH~6.5 within the trans-Golgi network.	Histidine	30-39	furin, paired basic amino acid cleaving enzyme	Homo sapiens	107-112
11325823-1	2001	Allele loss and loss of expression of fragile histidine triad (FHIT), a putative tumor suppressor gene located in chromosome region 3p14.2, are frequent in several types of cancers.	Histidine	46-55	fragile histidine triad diadenosine triphosphatase	Homo sapiens	63-67
17701542-0	2007	Histidine and not tyrosine is required for the peroxide-induced formation of haem to protein cross-linked myoglobin.	Histidine	0-9	myoglobin	Physeter catodon	106-115
17701542-9	2007	Moreover, addition of a distal histidine to myoglobin from Aplysia limacina, that naturally lacks this histidine, restores the haem protein"s capacity to generate haem to protein cross-links.	Histidine	31-40	myoglobin	Physeter catodon	44-53
17701542-9	2007	Moreover, addition of a distal histidine to myoglobin from Aplysia limacina, that naturally lacks this histidine, restores the haem protein"s capacity to generate haem to protein cross-links.	Histidine	103-112	myoglobin	Physeter catodon	44-53
11327770-5	2001	Here, we present the solution structure of a C-terminal fragment of IF(1) (44-84) containing all five of the histidine residues present in the sequence.	Histidine	109-118	ATP synthase inhibitory factor subunit 1	Bos taurus	68-73
22743102-4	2012	Previous studies identified a histidine residue (His69) that functions as a pH sensor in the propeptide of furin (PRO(FUR)), which regulates furin activation at pH~6.5 within the trans-Golgi network.	Histidine	30-39	furin, paired basic amino acid cleaving enzyme	Homo sapiens	141-146
11305910-0	2001	Contribution of the active site histidine residues of ribonuclease A to nucleic acid binding.	Histidine	32-41	ribonuclease A family member 1, pancreatic	Homo sapiens	54-68
17468165-5	2007	Oxygen, nitric oxide, or carbon monoxide can displace the distal histidine which, in ferrous Ngb as well as in ferric Ngb, is bound to the iron, yielding a reversible adduct.	Histidine	65-74	neuroglobin	Mus musculus	93-96
22822061-8	2012	Prediction of whole hTLR9 ECD-CpG ODN interactions revealed that Arg-337 and Lys-338 directly contact CpG ODN through hydrogen bonding, whereas Lys-347, Arg-348, and His-353 contribute to stabilizing the shape of the ligand binding region.	Histidine	166-169	toll like receptor 9	Homo sapiens	20-25
17468165-5	2007	Oxygen, nitric oxide, or carbon monoxide can displace the distal histidine which, in ferrous Ngb as well as in ferric Ngb, is bound to the iron, yielding a reversible adduct.	Histidine	65-74	neuroglobin	Mus musculus	118-121
11312671-0	2001	Down-modulation of the costimulatory molecule, CD28, is a conserved activity of multiple SIV Nefs and is dependent on histidine 196 of Nef.	Histidine	118-127	CD28 molecule	Homo sapiens	47-51
22767596-2	2012	L-histidine decarboxylase (HDC) is the primary enzyme responsible for histamine synthesis and produces histamine from histidine in a one-step reaction.	Histidine	2-11	histidine decarboxylase	Homo sapiens	27-30
11096085-8	2001	In contrast, ATP activated a chimera containing the hIK1 C-terminal amino acids His(299)-Lys(427).	Histidine	80-83	potassium calcium-activated channel subfamily N member 4	Homo sapiens	52-56
17468165-7	2007	We report the results of extended (90 ns) molecular dynamics simulations in water of ferrous deoxy and carboxy murine neuroglobin, which are both coordinated on the distal site, in the latter case by CO and in the former one by the distal His(64)(E7).	Histidine	239-242	neuroglobin	Mus musculus	118-129
22843886-2	2012	AIM: Our study aimed to characterise alterations in the immunohistochemical expression of the Fragile Histidine Traid (FHIT) and Cyclin-dependent Kinase Inhibitor 2A (CDKN2A) (p16(INK4a)) genes during tumour progression model from PSA to Ca-ex-PA in a cross sectional study.	Histidine	102-111	fragile histidine triad diadenosine triphosphatase	Homo sapiens	119-123
17475521-2	2007	msh-2(RIP-LK1) exhibited a mutator phenotype conferring a 17-fold increase in the frequency of spontaneous mitotic reversion of his-3 allele K458.	Histidine	128-131	mutS homolog 2	Homo sapiens	0-5
17475521-3	2007	In msh-2(RIP-LK1) homozygotes, recombination frequency at the his-3 locus increased up to 2.9-fold over that in msh-2(+) diploids.	Histidine	62-65	mutS homolog 2	Homo sapiens	3-8
17475521-3	2007	In msh-2(RIP-LK1) homozygotes, recombination frequency at the his-3 locus increased up to 2.9-fold over that in msh-2(+) diploids.	Histidine	62-65	mutS homolog 2	Homo sapiens	112-117
11413003-5	2001	Deletion of the four octarepeats or mutation of the histidine residues (H68/76 dyad) in the central two repeats abolished endocytosis, indicating that the internalization of PrP(C) is governed by metal binding to the octarepeats.	Histidine	52-61	prion protein	Mus musculus	174-180
11248707-4	2001	Based on our recent functional expression of the full-length rat and human dihydroorotate dehydrogenase, here we expressed N-terminal-truncated C-terminal-histidine-tagged constructs of the mouse, rat and human enzymes in Escherichia coli.	Histidine	155-164	dihydroorotate dehydrogenase	Mus musculus	75-103
22315171-1	2012	BACKGROUND: The relationship between the expression of CD133 and fragile histidine triad (FHIT) or prognosis in Chinese colorectal adenocarcinoma is unknown and needs to be explored.	Histidine	73-82	prominin 1	Homo sapiens	55-60
17438030-3	2007	To investigate the LcrV-TLR2 interaction in vitro, His-tagged recombinant LcrV (rLcrV) from Yersinia pestis was cloned and expressed in Escherichia coli and purified through Ni-nitrilotriacetic acid column chromatography.	Histidine	51-54	toll-like receptor 2	Mus musculus	24-28
17596760-1	2007	OBJECTIVE: This cross-sectional study was intended to assess the association between immunohistochemical analysis of p16 and fragile histidine triad (FHIT) and the presence of precancerous cervical lesions.	Histidine	133-142	fragile histidine triad diadenosine triphosphatase	Homo sapiens	150-154
11237699-1	2001	A histidine-tagged, carboxy-terminal fragment of the murine double minute 2 gene product, p90(MDM2), was purified by Ni--NTA chromatography and preparative gel electrophoresis.	Histidine	2-11	transferrin receptor	Mus musculus	90-93
22315171-1	2012	BACKGROUND: The relationship between the expression of CD133 and fragile histidine triad (FHIT) or prognosis in Chinese colorectal adenocarcinoma is unknown and needs to be explored.	Histidine	73-82	fragile histidine triad diadenosine triphosphatase	Homo sapiens	90-94
21895963-6	2012	The molecular interaction of PED/PEA-15 with 67LR was confirmed by pull-down experiments with recombinant His-tagged 37LRP on lysates of PED/PEA-15 transfected HEK-293 cells.	Histidine	106-109	OCA2 melanosomal transmembrane protein	Homo sapiens	29-32
21895963-6	2012	The molecular interaction of PED/PEA-15 with 67LR was confirmed by pull-down experiments with recombinant His-tagged 37LRP on lysates of PED/PEA-15 transfected HEK-293 cells.	Histidine	106-109	OCA2 melanosomal transmembrane protein	Homo sapiens	137-140
11063749-7	2001	Likewise, Leu-344, Leu-345, Cys-388, and Cys-393 in the cysteine- and histidine-rich 1 domain of p300 have also been shown to be essential for the functional interaction.	Histidine	70-79	E1A binding protein p300	Homo sapiens	97-101
21118644-1	2007	BACKGROUND: Fragile histidine triad (FHIT) is a candidate tumor suppressor gene.	Histidine	20-29	fragile histidine triad diadenosine triphosphatase	Homo sapiens	37-41
22196020-5	2012	Five examples of these secondary interactions are discussed: carbonic anhydrase (where secondary interactions involving histidine residues stabilize the zinc-binding site thermodynamically and kinetically), retroviral nucleocapsid proteins and TRAF proteins (where cysteinate sulfur to peptide NH hydrogen bonds contribute to the structural relationships between adjacent domains), and nucleic acid binding proteins, Zif268 and TIS11 where secondary interactions participate in protein-nucleic acid interactions.	Histidine	120-129	ZFP36 ring finger protein	Homo sapiens	428-433
17531387-2	2007	Histamine is synthesized by histidine decarboxylase (HDC) from histidine.	Histidine	28-37	histidine decarboxylase	Rattus norvegicus	53-56
17531387-7	2007	In experiment 3, we intraperitoneally injected fluoromethylhistidine (FMH), an antagonistic inhibitor of HDC, in rats fed with a histidine-enriched diet.	Histidine	59-68	histidine decarboxylase	Rattus norvegicus	105-108
22342614-9	2012	In comparison with a lower resolution structure of this enzyme, binding of the inhibitor induces a conformational change in part of the TIM barrel loop 4, as well as protonation of the active site histidine.	Histidine	197-206	Rho guanine nucleotide exchange factor 5	Homo sapiens	136-139
17482720-1	2007	Recently we have demonstrated that replacing His(6) by constrained amino acids(2) in the well-known antagonist SHU-9119 resulted in potent and selective antagonist ligands especially at the hMC3R and hMC5 receptors.	Histidine	45-48	melanocortin 3 receptor	Homo sapiens	190-195
11230563-4	2001	Taking advantage of this AHK4-dependent His--&gt;Asp phosphorelay system in E. coli, a phosphorelay interaction between the Arabidopsis His-kinase and histidine-containing phosphotransmitters (AHPs) was also demonstrated for the first time.	Histidine	40-43	CHASE domain containing histidine kinase protein	Arabidopsis thaliana	25-29
11230563-4	2001	Taking advantage of this AHK4-dependent His--&gt;Asp phosphorelay system in E. coli, a phosphorelay interaction between the Arabidopsis His-kinase and histidine-containing phosphotransmitters (AHPs) was also demonstrated for the first time.	Histidine	151-160	CHASE domain containing histidine kinase protein	Arabidopsis thaliana	25-29
11341960-2	2001	Alignment of the amino acid sequences of FAE1 KCS, KCS1, and five other putative elongase condensing enzymes (KCSs) revealed the presence of six conserved cysteine and four conserved histidine residues.	Histidine	183-192	3-ketoacyl-CoA synthase 18	Arabidopsis thaliana	41-45
11208993-7	2001	A T855C polymorphism resulting in a histidine to arginine transition was present in the open reading frame of NPT2.	Histidine	36-45	solute carrier family 34 member 1	Homo sapiens	110-114
17475008-8	2007	Molecular docking experiments identified key residues in donor and acceptor recognition and provided insight into the catalytic mechanism of UGT glucuronidation, suggesting the human UGT1A1 residue histidine 39 (H39) as a general base and the residue aspartic acid 151 (D151) as an important electron-transfer helper.	Histidine	198-207	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	141-144
22389474-7	2012	Purified His(6)-GS and His(6)-GPI proteins bound to type I collagen, and His(6)-GS also bound to laminin, and their level of binding was higher at pH 5.5 than at pH 6.5.	Histidine	23-26	glucose-6-phosphate isomerase	Lactobacillus crispatus ST1	30-33
11156380-6	2000	Using an RFLP that distinguishes an arginine to histidine change in exon 7 of the SULT1A1 gene, we characterized SULT1A1 genotypes in relation to breast cancer risk.	Histidine	48-57	sulfotransferase family 1A member 1	Homo sapiens	82-89
22077443-8	2012	Furthermore, we found the interaction of LOX-1 with the HNE-histidine adduct to have a dissociation constant of 1.22x10(-8) M using a surface plasmon resonance assay.	Histidine	60-69	oxidized low density lipoprotein receptor 1	Homo sapiens	41-46
11085938-0	2000	Association of FHIT (fragile histidine triad), a candidate tumour suppressor gene, with the ubiquitin-conjugating enzyme hUBC9.	Histidine	29-38	fragile histidine triad diadenosine triphosphatase	Homo sapiens	15-19
11085938-0	2000	Association of FHIT (fragile histidine triad), a candidate tumour suppressor gene, with the ubiquitin-conjugating enzyme hUBC9.	Histidine	29-38	ubiquitin conjugating enzyme E2 I	Homo sapiens	121-126
17382284-3	2007	Pnc1p displays a cluster of surface histidine residues likely responsible for its co-fractionation with IDH from Ni(2+)-coupled chromatography resins.	Histidine	36-45	nicotinamidase	Saccharomyces cerevisiae S288C	0-5
17382284-4	2007	Researchers expressing histidine-tagged proteins in yeast should be aware of the propensity of Pnc1p to crystallize, even when overwhelmed in concentration by the protein of interest.	Histidine	23-32	nicotinamidase	Saccharomyces cerevisiae S288C	95-100
22068049-8	2012	Serum His-Gag p41-specific antibody levels were found to be significantly higher at 1 and 0.5 mug doses of Gag p41-His-Ni-NCs (His-Gag p41 equivalent) compared with His-Gag p41 (1 mug) adjuvanted with aluminum hydroxide (AH).	Histidine	6-9	erythrocyte membrane protein band 4.1	Mus musculus	14-17
17303572-5	2007	In this model the Switch 1 region acts as an allosteric activator that facilitates electrostatic interactions between Arg-196 in Kir/Gem and Asp-194, -270, and -272 in the nucleotide-kinase (NK) domain of Cavbeta3 and wedging Val-223 and His-225 of Kir/Gem into a hydrophobic pocket in the NK domain.	Histidine	238-241	GTP binding protein overexpressed in skeletal muscle	Homo sapiens	129-132
17303572-5	2007	In this model the Switch 1 region acts as an allosteric activator that facilitates electrostatic interactions between Arg-196 in Kir/Gem and Asp-194, -270, and -272 in the nucleotide-kinase (NK) domain of Cavbeta3 and wedging Val-223 and His-225 of Kir/Gem into a hydrophobic pocket in the NK domain.	Histidine	238-241	GTP binding protein overexpressed in skeletal muscle	Homo sapiens	133-136
11085938-1	2000	FHIT (fragile histidine triad), a candidate tumour suppressor gene, has recently been identified at chromosomal region 3p14.2, and deletions of the gene have been reported in many types of human cancer.	Histidine	14-23	fragile histidine triad diadenosine triphosphatase	Homo sapiens	0-4
17303572-5	2007	In this model the Switch 1 region acts as an allosteric activator that facilitates electrostatic interactions between Arg-196 in Kir/Gem and Asp-194, -270, and -272 in the nucleotide-kinase (NK) domain of Cavbeta3 and wedging Val-223 and His-225 of Kir/Gem into a hydrophobic pocket in the NK domain.	Histidine	238-241	GTP binding protein overexpressed in skeletal muscle	Homo sapiens	249-252
11090193-2	2000	Addition of six-histidine (His(6)) affinity tags to selective sites within PrP106 resulted unexpectedly in new PrP proteins that spontaneously adopted protease-resistant conformations when expressed in neuroblastoma cells and Tg mice.	Histidine	27-30	prion protein	Mus musculus	75-78
22068049-8	2012	Serum His-Gag p41-specific antibody levels were found to be significantly higher at 1 and 0.5 mug doses of Gag p41-His-Ni-NCs (His-Gag p41 equivalent) compared with His-Gag p41 (1 mug) adjuvanted with aluminum hydroxide (AH).	Histidine	6-9	erythrocyte membrane protein band 4.1	Mus musculus	111-114
11090193-2	2000	Addition of six-histidine (His(6)) affinity tags to selective sites within PrP106 resulted unexpectedly in new PrP proteins that spontaneously adopted protease-resistant conformations when expressed in neuroblastoma cells and Tg mice.	Histidine	27-30	prion protein	Mus musculus	111-114
17303572-5	2007	In this model the Switch 1 region acts as an allosteric activator that facilitates electrostatic interactions between Arg-196 in Kir/Gem and Asp-194, -270, and -272 in the nucleotide-kinase (NK) domain of Cavbeta3 and wedging Val-223 and His-225 of Kir/Gem into a hydrophobic pocket in the NK domain.	Histidine	238-241	GTP binding protein overexpressed in skeletal muscle	Homo sapiens	253-256
22068049-8	2012	Serum His-Gag p41-specific antibody levels were found to be significantly higher at 1 and 0.5 mug doses of Gag p41-His-Ni-NCs (His-Gag p41 equivalent) compared with His-Gag p41 (1 mug) adjuvanted with aluminum hydroxide (AH).	Histidine	6-9	erythrocyte membrane protein band 4.1	Mus musculus	111-114
22068049-8	2012	Serum His-Gag p41-specific antibody levels were found to be significantly higher at 1 and 0.5 mug doses of Gag p41-His-Ni-NCs (His-Gag p41 equivalent) compared with His-Gag p41 (1 mug) adjuvanted with aluminum hydroxide (AH).	Histidine	6-9	erythrocyte membrane protein band 4.1	Mus musculus	111-114
22068049-8	2012	Serum His-Gag p41-specific antibody levels were found to be significantly higher at 1 and 0.5 mug doses of Gag p41-His-Ni-NCs (His-Gag p41 equivalent) compared with His-Gag p41 (1 mug) adjuvanted with aluminum hydroxide (AH).	Histidine	115-118	erythrocyte membrane protein band 4.1	Mus musculus	14-17
11087949-4	2000	As a result, the rate of autoxidation of Tetrahymena oxymyoglobin (MbO(2)) was found to be almost comparable to that of sperm whale MbO(2) over a wide range of pH 4-12 in 0.1 M buffer at 25 degrees C. Moreover, both pH profiles exhibited the remarkable proton-assisted process, which can be performed in sperm whale myoglobin by the distal (E7) histidine as its catalytic residue.	Histidine	345-354	myoglobin	Physeter catodon	56-65
22068049-8	2012	Serum His-Gag p41-specific antibody levels were found to be significantly higher at 1 and 0.5 mug doses of Gag p41-His-Ni-NCs (His-Gag p41 equivalent) compared with His-Gag p41 (1 mug) adjuvanted with aluminum hydroxide (AH).	Histidine	115-118	erythrocyte membrane protein band 4.1	Mus musculus	111-114
11087949-5	2000	These kinetic observations are also in full accord with spectral examinations for the presence of a distal histidine in ciliated protozoa myoglobin.	Histidine	107-116	myoglobin	Physeter catodon	138-147
17215247-7	2007	The solution structure of yeast Cox4 elucidated by multidimensional NMR reveals a C-terminal globular domain consisting of two beta sheets analogous to the bovine ortholog except the loop containing the coordinating His in the yeast protein and the fourth Cys in the bovine protein are in different positions in the two structures.	Histidine	216-219	cytochrome c oxidase subunit IV	Saccharomyces cerevisiae S288C	32-36
11025551-2	2000	The overall three-dimensional structures of the enzymes are composed of similar alpha/beta TIM-barrels, and the active site residues Tyr 50, His 113, and Trp 114 interacting with the hydrophilic heads of inhibitors are conserved.	Histidine	141-144	Rho guanine nucleotide exchange factor 5	Homo sapiens	91-94
22068049-8	2012	Serum His-Gag p41-specific antibody levels were found to be significantly higher at 1 and 0.5 mug doses of Gag p41-His-Ni-NCs (His-Gag p41 equivalent) compared with His-Gag p41 (1 mug) adjuvanted with aluminum hydroxide (AH).	Histidine	115-118	erythrocyte membrane protein band 4.1	Mus musculus	111-114
11063570-9	2000	These results indicate that the AE1 binding site is located within the first 17 residues of CAII, and that the interaction is mediated by electrostatic interactions involving histidine and/or lysine residues.	Histidine	175-184	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	32-35
22068049-8	2012	Serum His-Gag p41-specific antibody levels were found to be significantly higher at 1 and 0.5 mug doses of Gag p41-His-Ni-NCs (His-Gag p41 equivalent) compared with His-Gag p41 (1 mug) adjuvanted with aluminum hydroxide (AH).	Histidine	115-118	erythrocyte membrane protein band 4.1	Mus musculus	111-114
22068049-8	2012	Serum His-Gag p41-specific antibody levels were found to be significantly higher at 1 and 0.5 mug doses of Gag p41-His-Ni-NCs (His-Gag p41 equivalent) compared with His-Gag p41 (1 mug) adjuvanted with aluminum hydroxide (AH).	Histidine	115-118	erythrocyte membrane protein band 4.1	Mus musculus	14-17
22068049-8	2012	Serum His-Gag p41-specific antibody levels were found to be significantly higher at 1 and 0.5 mug doses of Gag p41-His-Ni-NCs (His-Gag p41 equivalent) compared with His-Gag p41 (1 mug) adjuvanted with aluminum hydroxide (AH).	Histidine	115-118	erythrocyte membrane protein band 4.1	Mus musculus	111-114
17290983-6	2007	The effective nodal plane of low-spin NP1, NP4, and NP2 complexes is in all cases of imidazole and histamine complexes quite similar to the average of the His-59 or -57 and the exogenous ligand angles seen in the X-ray crystal structures.	Histidine	155-158	neuropilin 1	Homo sapiens	38-41
22068049-8	2012	Serum His-Gag p41-specific antibody levels were found to be significantly higher at 1 and 0.5 mug doses of Gag p41-His-Ni-NCs (His-Gag p41 equivalent) compared with His-Gag p41 (1 mug) adjuvanted with aluminum hydroxide (AH).	Histidine	115-118	erythrocyte membrane protein band 4.1	Mus musculus	111-114
11029294-10	2000	Other contributors to the distinct pH sensitivity were histidine residues in the COOH terminus, whose numbers are fewer in Kir4.1 than Kir1.1.	Histidine	55-64	potassium inwardly rectifying channel subfamily J member 1	Homo sapiens	135-141
11029294-11	2000	Mutation of two of these histidine residues in Kir1.1 (H342Q/H354N) reduced CO(2)/pH sensitivities, whereas the creation of two histidines (S328H/G340H) in Kir4.1 increased the CO(2)/pH sensitivities.	Histidine	25-34	potassium inwardly rectifying channel subfamily J member 1	Homo sapiens	47-53
22068049-8	2012	Serum His-Gag p41-specific antibody levels were found to be significantly higher at 1 and 0.5 mug doses of Gag p41-His-Ni-NCs (His-Gag p41 equivalent) compared with His-Gag p41 (1 mug) adjuvanted with aluminum hydroxide (AH).	Histidine	115-118	erythrocyte membrane protein band 4.1	Mus musculus	111-114
22068049-8	2012	Serum His-Gag p41-specific antibody levels were found to be significantly higher at 1 and 0.5 mug doses of Gag p41-His-Ni-NCs (His-Gag p41 equivalent) compared with His-Gag p41 (1 mug) adjuvanted with aluminum hydroxide (AH).	Histidine	115-118	erythrocyte membrane protein band 4.1	Mus musculus	14-17
17250822-3	2007	Major anatomical and functional disturbances were detected in the His-Purkinje system of adult Nkx2.5(+/-)/Cx40(eGFP/+) mice, including hypoplasia of eGFP-positive Purkinje fibers and the disorganization of the Purkinje fiber network in the ventricular apex.	Histidine	66-69	NK2 homeobox 5	Mus musculus	95-101
22068049-8	2012	Serum His-Gag p41-specific antibody levels were found to be significantly higher at 1 and 0.5 mug doses of Gag p41-His-Ni-NCs (His-Gag p41 equivalent) compared with His-Gag p41 (1 mug) adjuvanted with aluminum hydroxide (AH).	Histidine	115-118	erythrocyte membrane protein band 4.1	Mus musculus	111-114
11023836-0	2000	Inhibition by etomoxir of rat liver carnitine octanoyltransferase is produced through the co-ordinate interaction with two histidine residues.	Histidine	123-132	carnitine O-octanoyltransferase	Rattus norvegicus	36-65
22068049-8	2012	Serum His-Gag p41-specific antibody levels were found to be significantly higher at 1 and 0.5 mug doses of Gag p41-His-Ni-NCs (His-Gag p41 equivalent) compared with His-Gag p41 (1 mug) adjuvanted with aluminum hydroxide (AH).	Histidine	115-118	erythrocyte membrane protein band 4.1	Mus musculus	111-114
22068049-8	2012	Serum His-Gag p41-specific antibody levels were found to be significantly higher at 1 and 0.5 mug doses of Gag p41-His-Ni-NCs (His-Gag p41 equivalent) compared with His-Gag p41 (1 mug) adjuvanted with aluminum hydroxide (AH).	Histidine	115-118	erythrocyte membrane protein band 4.1	Mus musculus	111-114
22068049-9	2012	The serum IgG2a levels induced by Gag p41-His-Ni-NCs (1 mug) were significantly higher than AH adjuvanted His-Gag p41.	Histidine	42-45	erythrocyte membrane protein band 4.1	Mus musculus	38-41
17158894-4	2007	Like human MIF, histidine-tagged purified recombinant PMIF shows tautomerase and oxidoreductase activities (although the activities are reduced compared to those of histidine-tagged human MIF) and efficiently inhibits AP-1 activity in human embryonic kidney cells.	Histidine	16-25	macrophage migration inhibitory factor	Homo sapiens	11-14
17158894-4	2007	Like human MIF, histidine-tagged purified recombinant PMIF shows tautomerase and oxidoreductase activities (although the activities are reduced compared to those of histidine-tagged human MIF) and efficiently inhibits AP-1 activity in human embryonic kidney cells.	Histidine	16-25	macrophage migration inhibitory factor	Homo sapiens	55-58
21963446-8	2012	A comparison of sequences surrounding the cleavage site revealed human GAA contains histidine at 201 while other species contain hydrophobic amino acids at position 201 in the otherwise conserved sequence.	Histidine	84-93	alpha glucosidase	Homo sapiens	71-74
17158894-4	2007	Like human MIF, histidine-tagged purified recombinant PMIF shows tautomerase and oxidoreductase activities (although the activities are reduced compared to those of histidine-tagged human MIF) and efficiently inhibits AP-1 activity in human embryonic kidney cells.	Histidine	165-174	macrophage migration inhibitory factor	Homo sapiens	55-58
17169356-8	2007	Likewise, the ischemia induced increase in the number of CD68-positive cells after 24 h was suppressed by L-histidine injections.	Histidine	106-117	Cd68 molecule	Rattus norvegicus	57-61
11003587-9	2000	The data indicate that the NH(2)-terminal Tx [4-7 repeats of a sequence motif His-(Glu/Ala)-Glu-Ala-His] extension confers a specific conformational modulation in the slow skeletal muscle TnT.	Histidine	78-81	troponin T1, skeletal, slow	Mus musculus	188-191
11003587-9	2000	The data indicate that the NH(2)-terminal Tx [4-7 repeats of a sequence motif His-(Glu/Ala)-Glu-Ala-His] extension confers a specific conformational modulation in the slow skeletal muscle TnT.	Histidine	100-103	troponin T1, skeletal, slow	Mus musculus	188-191
11018721-2	2000	The murine Unp oncoprotein and its human homologue, Unph, both contain regions similar to the conserved Cys and His boxes common to all the Ubps.	Histidine	112-115	ubiquitin specific peptidase 4 (proto-oncogene)	Mus musculus	11-14
11018721-4	2000	Mutation of the conserved Unp Cys and His residues abolishes this activity, and identifies the likely His residue in the catalytic triad.	Histidine	102-105	ubiquitin specific peptidase 4 (proto-oncogene)	Mus musculus	26-29
17166829-7	2007	In contrast, we found that CBP intrinsic activity was increased by Akt through threonine 1872, a consensus site for Akt in the cysteine- and histidine-rich 3 domain of CBP, indicating that such enhanced transcriptional potential of CBP did not serve to activate ERbeta.	Histidine	141-150	estrogen receptor 2	Homo sapiens	262-268
10964565-1	2000	We have used a method for the two-dimensional crystallization of retroviral structural proteins to obtain a three-dimensional structure of negatively stained, membrane-bound, histidine-tagged Moloney murine leukemia virus (M-MuLV) capsid protein (his-MoCA) arrays.	Histidine	175-184	dedicator of cytokinesis 3	Homo sapiens	251-255
22613411-1	2012	OBJECTIVES: The role and clinical significance of fragile histidine triad (FHIT) gene in the pathogenesis of bladder urothelial carcinoma (UC) and the potential of Fhit protein as a prognostic biomarker for UC were investigated.	Histidine	58-67	fragile histidine triad diadenosine triphosphatase	Homo sapiens	75-79
10951267-2	2000	Histidine decarboxylase, the only enzyme that catalyzes the formation of histamine from L-histidine, is an essential regulator of histamine levels.	Histidine	88-99	histidine decarboxylase	Homo sapiens	0-23
22768673-6	2012	We identified a heterozygous T to C transition in exon 5 of the LMNB2 gene (c.694T&gt;C), and, consequently, tyrosine for histidine (p.Y232H).	Histidine	122-131	lamin B2	Homo sapiens	64-69
10945855-6	2000	The most pronounced effect was observed for p-fluorofentanyl, suggesting that an interaction between the 4-fluorophenylpropanamide moiety of the drug and residues Trp-318 and His-319 is important for the resulting enhanced GIRK1/GIRK2 channel activation through the mu-opioid receptor.	Histidine	175-178	potassium inwardly rectifying channel subfamily J member 3	Homo sapiens	223-228
10877846-3	2000	In this work, we show that an ade16 ade17 double disruption also leads to histidine auxotrophy, similar to the adenine/histidine auxotrophy of ade3 mutant yeast strains.	Histidine	74-83	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase ADE17	Saccharomyces cerevisiae S288C	36-41
10877846-3	2000	In this work, we show that an ade16 ade17 double disruption also leads to histidine auxotrophy, similar to the adenine/histidine auxotrophy of ade3 mutant yeast strains.	Histidine	119-128	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase ADE17	Saccharomyces cerevisiae S288C	36-41
10931311-0	2000	Functional roles of conserved amino acid residues surrounding the phosphorylatable histidine of the yeast phosphorelay protein YPD1.	Histidine	83-92	Ypd1p	Saccharomyces cerevisiae S288C	127-131
10931311-1	2000	The histidine-containing phosphotransfer (HPt) protein YPD1 is an osmoregulatory protein in yeast that facilitates phosphoryl transfer between the two response regulator domains associated with SLN1 and SSK1.	Histidine	4-13	Ypd1p	Saccharomyces cerevisiae S288C	55-59
17085448-11	2007	Taken together, His-15 of HPr processes sensing information, while Arg-17 is involved in determining the genetic output.	Histidine	16-19	haptoglobin-related protein	Homo sapiens	26-29
17090548-6	2007	The subunits constituting PF4 form a tetrahedron having at its corners a RPRH motif that mimics (in reverse orientation) the Gly-His-Arg-Pro-amide peptides that co-crystallize with fibrin.	Histidine	129-132	platelet factor 4	Homo sapiens	26-29
10931311-1	2000	The histidine-containing phosphotransfer (HPt) protein YPD1 is an osmoregulatory protein in yeast that facilitates phosphoryl transfer between the two response regulator domains associated with SLN1 and SSK1.	Histidine	4-13	histidine kinase	Saccharomyces cerevisiae S288C	194-198
22083954-5	2012	We provide the first evidence that HPL-1 interacts with HIS-24 monomethylated at lysine 14 (HIS-24K14me1) and associates in vivo with promoters of genes involved in antimicrobial response.	Histidine	56-59	Chromo domain-containing protein	Caenorhabditis elegans	35-40
10860499-0	2000	Histidine-tagged ubiquitin substitutes for wild-type ubiquitin in Saccharomyces cerevisiae and facilitates isolation and identification of in vivo substrates of the ubiquitin pathway.	Histidine	0-9	ubiquitin	Saccharomyces cerevisiae S288C	17-26
17035026-0	2007	Modifications of the pyroglutamic acid and histidine residues in thyrotropin-releasing hormone (TRH) yield analogs with selectivity for TRH receptor type 2 over type 1.	Histidine	43-52	thyrotropin releasing hormone	Homo sapiens	65-94
17035026-0	2007	Modifications of the pyroglutamic acid and histidine residues in thyrotropin-releasing hormone (TRH) yield analogs with selectivity for TRH receptor type 2 over type 1.	Histidine	43-52	thyrotropin releasing hormone	Homo sapiens	96-99
10860499-0	2000	Histidine-tagged ubiquitin substitutes for wild-type ubiquitin in Saccharomyces cerevisiae and facilitates isolation and identification of in vivo substrates of the ubiquitin pathway.	Histidine	0-9	ubiquitin	Saccharomyces cerevisiae S288C	53-62
22006939-7	2011	Substituting the Tyr276 residue of phyB with histidine (Y276H) is known to confer constitutive phyB signaling.	Histidine	45-54	phytochrome B	Arabidopsis thaliana	95-99
10860499-0	2000	Histidine-tagged ubiquitin substitutes for wild-type ubiquitin in Saccharomyces cerevisiae and facilitates isolation and identification of in vivo substrates of the ubiquitin pathway.	Histidine	0-9	ubiquitin	Saccharomyces cerevisiae S288C	53-62
10860499-2	2000	The utility of a N-terminal histidine-tagged ubiquitin (HisUb) for in vivo conjugation and isolation of ubiquitinated proteins by metal chelation chromatography is conditioned by the requirement that HisUb conjugate to the same set of proteins as wild-type ubiquitin.	Histidine	28-37	ubiquitin	Saccharomyces cerevisiae S288C	45-54
10860499-2	2000	The utility of a N-terminal histidine-tagged ubiquitin (HisUb) for in vivo conjugation and isolation of ubiquitinated proteins by metal chelation chromatography is conditioned by the requirement that HisUb conjugate to the same set of proteins as wild-type ubiquitin.	Histidine	28-37	ubiquitin	Saccharomyces cerevisiae S288C	104-113
10873085-1	2000	Abnormalities in structure and expression of the fragile histidine triad transcription (FHIT) gene have been reported in a variety of cancers, including endometrial cancers.	Histidine	57-66	fragile histidine triad diadenosine triphosphatase	Homo sapiens	88-92
17035026-0	2007	Modifications of the pyroglutamic acid and histidine residues in thyrotropin-releasing hormone (TRH) yield analogs with selectivity for TRH receptor type 2 over type 1.	Histidine	43-52	thyrotropin releasing hormone	Homo sapiens	136-139
17035026-3	2007	For example, the most selective agonist of the series 13, in which pGlu is replaced with the pAad and histidine residue is substituted at the N-1 position with an isopropyl group, was found to activate TRH-R2 with a potency (EC(50)=1.9microM) but did not activate TRH-R1 (potency&gt;100 microM); that is, exhibited &gt;51-fold greater selectivity for TRH-R2 versus TRH-R1.	Histidine	102-111	thyrotropin releasing hormone	Homo sapiens	202-205
17035026-3	2007	For example, the most selective agonist of the series 13, in which pGlu is replaced with the pAad and histidine residue is substituted at the N-1 position with an isopropyl group, was found to activate TRH-R2 with a potency (EC(50)=1.9microM) but did not activate TRH-R1 (potency&gt;100 microM); that is, exhibited &gt;51-fold greater selectivity for TRH-R2 versus TRH-R1.	Histidine	102-111	thyrotropin releasing hormone	Homo sapiens	264-267
17035026-3	2007	For example, the most selective agonist of the series 13, in which pGlu is replaced with the pAad and histidine residue is substituted at the N-1 position with an isopropyl group, was found to activate TRH-R2 with a potency (EC(50)=1.9microM) but did not activate TRH-R1 (potency&gt;100 microM); that is, exhibited &gt;51-fold greater selectivity for TRH-R2 versus TRH-R1.	Histidine	102-111	thyrotropin releasing hormone	Homo sapiens	264-267
17035026-3	2007	For example, the most selective agonist of the series 13, in which pGlu is replaced with the pAad and histidine residue is substituted at the N-1 position with an isopropyl group, was found to activate TRH-R2 with a potency (EC(50)=1.9microM) but did not activate TRH-R1 (potency&gt;100 microM); that is, exhibited &gt;51-fold greater selectivity for TRH-R2 versus TRH-R1.	Histidine	102-111	thyrotropin releasing hormone	Homo sapiens	264-267
17902185-11	2007	The role played by His18 in the modulation of the biophysical properties of this hIAPP region was assessed by synthesising and studying the R18HrIAPP17-29 peptide; the replacement of a single Arg with a His residue is not sufficient to induce either amyloidogenic propensity or membrane interaction in this region.	Histidine	19-22	islet amyloid polypeptide	Homo sapiens	81-86
22545226-6	2011	Multiple methods have been employed to enhance the stability of Rnd1, including by cleavage of an N-terminal His expression tag and by addition of non-hydrolysable GMPPNP (beta: gamma-imidoguanosine 5"-triphosphate) nucleotide.	Histidine	109-112	Rho family GTPase 1	Homo sapiens	64-68
10813812-2	2000	The trans-substituted histidine to glycine mutant of sperm whale myoglobin (H93G Mb) is used to study energetics of proximal hydrogen bonding, proximal ligand-heme interactions, and coupling to distal ligand binding.	Histidine	22-31	myoglobin	Physeter catodon	65-74
21859715-13	2011	Treatment with the minor groove- and GC-specific chemical chromomycin A(3) demonstrated that chromomycin prevented His-Mor binding but could not disrupt a pre-formed His-Mor DNA complex, consistent with the prediction that Mor interacts with the minor groove of the GC-rich spacer in the Mor binding site.	Histidine	115-118	Mor	Escherichia phage Mu	119-122
10788495-3	2000	Functionally active Gbeta(5)gamma(2) dimers were purified from Sf9 cell membranes following coexpression of Gbeta(5) and Ggamma(2-His).	Histidine	130-133	succinate-CoA ligase GDP-forming subunit beta	Homo sapiens	20-25
10812172-1	2000	The fragile histidine triad (FHIT) gene is localized on chromosome 3p14 and spans the common fragile site FRA3B.	Histidine	12-21	fragile histidine triad diadenosine triphosphatase	Homo sapiens	29-33
10812172-1	2000	The fragile histidine triad (FHIT) gene is localized on chromosome 3p14 and spans the common fragile site FRA3B.	Histidine	12-21	fragile histidine triad diadenosine triphosphatase	Homo sapiens	106-111
17393360-1	2007	The FHIT gene, a member of the histidine triad gene family, is a tumor suppressor gene exhibiting deletions in the majority of human cancers.	Histidine	31-40	fragile histidine triad diadenosine triphosphatase	Homo sapiens	4-8
17913635-6	2007	The cDNA for bovine IF2(mt) was expressed in Escherichia coli under the control of the T7 polymerase promoter in a vector that provides a His(6)-tag at the C-terminus of the expressed protein.	Histidine	138-141	eukaryotic translation initiation factor 5B	Homo sapiens	20-23
21856937-8	2011	Finally, crystal structures of LR (histidine, H134) allele of FcgammaRIIa and FcgammaRIIa-HR reveal two distinct receptor dimers that may represent quaternary states on the cell surface.	Histidine	35-44	Fc gamma receptor IIa	Homo sapiens	62-73
18029758-6	2007	To clarify the pH-dependent binding mechanism of TLR3 at the structural level, we focused on some highly conserved histidine residues clustered at the N-terminal region of the TLR3 ECD.	Histidine	115-124	toll like receptor 3	Homo sapiens	49-53
18029758-6	2007	To clarify the pH-dependent binding mechanism of TLR3 at the structural level, we focused on some highly conserved histidine residues clustered at the N-terminal region of the TLR3 ECD.	Histidine	115-124	toll like receptor 3	Homo sapiens	176-180
10832607-11	2000	These results indicate that histidine increases interstitial adenosine concentration via NA release-mediated activation of ecto-5"-nucleotidase.	Histidine	28-37	5' nucleotidase, ecto	Rattus norvegicus	123-143
10754525-1	2000	BACKGROUND: The fragile histidine triad (FHIT) is frequently deleted and altered in many human cancers.	Histidine	24-33	fragile histidine triad diadenosine triphosphatase	Homo sapiens	41-45
17140699-3	2007	Very few modifications of [Arg(7)]-corazonin, originally isolated from cockroaches, are known, namely [His(7)]-corazonin which is expressed in certain locusts and the stick insect Carausius morosus, and [Thr(4), His(7)]-corazonin recently described from the honey bee Apis mellifera.	Histidine	103-106	pro-corazonin	Apis mellifera	35-44
21856937-8	2011	Finally, crystal structures of LR (histidine, H134) allele of FcgammaRIIa and FcgammaRIIa-HR reveal two distinct receptor dimers that may represent quaternary states on the cell surface.	Histidine	35-44	Fc gamma receptor IIa	Homo sapiens	78-89
17140699-3	2007	Very few modifications of [Arg(7)]-corazonin, originally isolated from cockroaches, are known, namely [His(7)]-corazonin which is expressed in certain locusts and the stick insect Carausius morosus, and [Thr(4), His(7)]-corazonin recently described from the honey bee Apis mellifera.	Histidine	103-106	pro-corazonin	Apis mellifera	111-120
17140699-3	2007	Very few modifications of [Arg(7)]-corazonin, originally isolated from cockroaches, are known, namely [His(7)]-corazonin which is expressed in certain locusts and the stick insect Carausius morosus, and [Thr(4), His(7)]-corazonin recently described from the honey bee Apis mellifera.	Histidine	103-106	pro-corazonin	Apis mellifera	111-120
21628446-4	2011	Chromatographic purification and structural analysis by matrix-assisted laser desorption/ionization time-of-flight/time-of-flight (MALDI-TOF/TOF) revealed an Ang II-like octapeptide, angioprotectin, with the sequence Pro-Glu-Val-Tyr-Ile-His-Pro-Phe, which differs from Ang II in Pro1 and Glu2 instead of Asp1 and Arg2.	Histidine	237-240	angiogenin	Homo sapiens	158-161
17140699-8	2007	The third isoform, [Thr(4), His(7)]-corazonin, seems to be restricted to bees (Apidae); whereas wasps (Vespidae) and a bumble bee (Apidae) express other corazonins, specifically [His(7)]-corazonin and [Tyr(3), Gln(7), Gln(10)]-corazonin, respectively.	Histidine	28-31	pro-corazonin	Apis mellifera	36-45
10779594-10	2000	The mutant His-485--&gt;Gln had a normal K(m) for glutathione disulphide reduction but only 0.8% residual catalytic activity when compared with wild-type GR, which confirms its function as an acid/base catalyst.	Histidine	11-14	glutathione reductase	Plasmodium falciparum 3D7	154-156
21788481-2	2011	The rare 1-His and 3-Cys coordination of mNT"s [2Fe-2S] leads to cluster lability that is strongly dependent on the presence of the single histidine ligand (His87).	Histidine	139-148	max binding protein	Mus musculus	41-44
10733881-0	2000	Expression, purification, and characterization of histidine-tagged mouse monoglyceride lipase from baculovirus-infected insect cells.	Histidine	50-59	monoglyceride lipase	Mus musculus	73-93
10733881-2	2000	The mouse MGL cDNA was subcloned into a baculovirus transfer vector in frame with a sequence encoding an N-terminal stretch of six histidine residues.	Histidine	131-140	monoglyceride lipase	Mus musculus	10-13
10733886-2	2000	We have cloned the human cDNA Fhit in the pPROEX-1 vector and expressed with high yield in Escherichia coli with the sequence Met-Gly-His(6)-Asp-Tyr-Asp-Ile-Pro-Thr-Thr followed by a rTEV protease cleavage site, denoted as "H6TV," fused to the N-terminus of Fhit.	Histidine	134-137	fragile histidine triad diadenosine triphosphatase	Homo sapiens	30-34
17023418-6	2006	The differential binding of AhR by Arnt and Arnt2 can be ascribed to a single His/Pro amino acid difference in the PASB region of Arnt and Arnt2, suggesting that the PASB/PASB interaction between bHLH-PAS transcription factors plays a selective role for their specific partner molecule.	Histidine	78-81	aryl hydrocarbon receptor	Homo sapiens	28-31
17157250-0	2006	Histidine phosphorylation of the potassium channel KCa3.1 by nucleoside diphosphate kinase B is required for activation of KCa3.1 and CD4 T cells.	Histidine	0-9	potassium calcium-activated channel subfamily N member 4	Homo sapiens	51-57
17157250-0	2006	Histidine phosphorylation of the potassium channel KCa3.1 by nucleoside diphosphate kinase B is required for activation of KCa3.1 and CD4 T cells.	Histidine	0-9	potassium calcium-activated channel subfamily N member 4	Homo sapiens	123-129
17157250-4	2006	NDPK-B directly binds and activates KCa3.1 by phosphorylating histidine 358 in the carboxyl terminus of KCa3.1.	Histidine	62-71	potassium calcium-activated channel subfamily N member 4	Homo sapiens	36-42
17157250-4	2006	NDPK-B directly binds and activates KCa3.1 by phosphorylating histidine 358 in the carboxyl terminus of KCa3.1.	Histidine	62-71	potassium calcium-activated channel subfamily N member 4	Homo sapiens	104-110
10713095-0	2000	Involvement of histidine residues in proton sensing of ROMK1 channel.	Histidine	15-24	potassium inwardly rectifying channel subfamily J member 1	Homo sapiens	55-60
21709160-5	2011	We expressed a C-terminally His-tagged form of human HEBP1 in yeast and purified it to homogeneity.	Histidine	28-31	heme binding protein 1	Homo sapiens	53-58
10713095-4	2000	To test the hypothesis that certain histidine residues are engaged in CO(2) and pH sensing of ROMK1, we performed experiments by systematic mutations of all histidine residues in the channel using the site-directed mutagenesis.	Histidine	36-45	potassium inwardly rectifying channel subfamily J member 1	Homo sapiens	94-99
10713095-4	2000	To test the hypothesis that certain histidine residues are engaged in CO(2) and pH sensing of ROMK1, we performed experiments by systematic mutations of all histidine residues in the channel using the site-directed mutagenesis.	Histidine	157-166	potassium inwardly rectifying channel subfamily J member 1	Homo sapiens	94-99
10713095-13	2000	These results therefore indicate that histidine residues contribute to the sensitivity of the ROMK1 channel to hypercapnia and intracellular acidosis.	Histidine	38-47	potassium inwardly rectifying channel subfamily J member 1	Homo sapiens	94-99
21683813-3	2011	Addition of the amino alcohol histidinol, which prevents the formation of histidinyl-tRNA(His), also increased DKK1 mRNA to a level similar to that observed when cells were deprived of all amino acids.	Histidine	90-93	dickkopf WNT signaling pathway inhibitor 1	Homo sapiens	111-115
10718748-0	2000	Mutation of histidine 286 of the human P2X4 purinoceptor removes extracellular pH sensitivity.	Histidine	12-21	purinergic receptor P2X 4	Homo sapiens	39-43
10718748-8	2000	Site-directed mutagenesis of histidine 286 (H286) to alanine completely abolished the pH sensitivity of the P2X4 receptor at all agonist concentrations.	Histidine	29-38	purinergic receptor P2X 4	Homo sapiens	108-112
10718748-10	2000	Mutagenesis of the other three histidines present in the P2X4 sequence had no effect on pH sensitivity.	Histidine	31-41	purinergic receptor P2X 4	Homo sapiens	57-61
10683263-2	2000	The primary catalytic residue, His-458 (maize C(4) PPDK), is involved in the ultimate transfer of the beta-phosphate from ATP to pyruvate.	Histidine	31-34	pyruvate, phosphate dikinase 1, chloroplastic	Zea mays	51-55
10683263-11	2000	The inability of RP to phosphorylate its native target Thr residue when Asn is substituted for His-458 documents that RP requires the His-P catalytic intermediate form of PPDK as its protein substrate.	Histidine	95-98	pyruvate, phosphate dikinase 1, chloroplastic	Zea mays	171-175
16963503-0	2006	Effect of charge substitutions at residue his-142 on voltage gating of connexin43 channels.	Histidine	42-45	gap junction protein alpha 1	Homo sapiens	71-81
16919600-1	2006	Histidine decarboxylase gene (HDC) encodes histidine decarboxylase which is the crucial enzyme for the biosynthesis of histidine.	Histidine	43-52	histidine decarboxylase	Homo sapiens	0-23
24048792-9	2011	Patients who were heterozygous for the CD32a (Fcgamma receptor IIa) 131 histidine (H) to arginine (R) polymorphism had a significantly decreased PFS (P = .009) after R-bortezomib compared with HH and RR homozygotes.	Histidine	72-81	Fc gamma receptor IIa	Homo sapiens	39-44
16919600-1	2006	Histidine decarboxylase gene (HDC) encodes histidine decarboxylase which is the crucial enzyme for the biosynthesis of histidine.	Histidine	43-52	histidine decarboxylase	Homo sapiens	30-33
24048792-9	2011	Patients who were heterozygous for the CD32a (Fcgamma receptor IIa) 131 histidine (H) to arginine (R) polymorphism had a significantly decreased PFS (P = .009) after R-bortezomib compared with HH and RR homozygotes.	Histidine	72-81	Fc gamma receptor IIa	Homo sapiens	46-66
16735122-1	2006	Thyrotropin-releasing hormone (TRH) analogues in which the N(1)-position of the imidazole ring of the centrally placed histidine residue is substituted with various alkyl groups were synthesized and studied as agonists for TRH receptor subtype 1 (TRH-R1) and subtype 2 (TRH-R2).	Histidine	119-128	thyrotropin releasing hormone	Homo sapiens	0-29
10691967-3	2000	The cDNA sequences of C. elegans predict two catalases very similar to each other throughout the molecule, except for the short C-terminal sequence; catalase-2 (500 residues long) carries a peroxisomal targeting signal 1-like sequence (Ser-His-Ile), whereas catalase-1 does not.	Histidine	240-243	Catalase-2	Caenorhabditis elegans	149-159
21530495-0	2011	A conserved histidine in human DNLZ/HEP is required for stimulation of HSPA9 ATPase activity.	Histidine	12-21	dynein axonemal heavy chain 8	Homo sapiens	77-83
16735122-1	2006	Thyrotropin-releasing hormone (TRH) analogues in which the N(1)-position of the imidazole ring of the centrally placed histidine residue is substituted with various alkyl groups were synthesized and studied as agonists for TRH receptor subtype 1 (TRH-R1) and subtype 2 (TRH-R2).	Histidine	119-128	thyrotropin releasing hormone	Homo sapiens	31-34
16735122-5	2006	The results of this study indicate that modulation of central histidine residue is important for designing analogues which were selective agonist at TRH receptor subtypes.	Histidine	62-71	thyrotropin releasing hormone	Homo sapiens	149-152
21830375-1	2011	BACKGROUND/AIMS: The fragile histidine triad (FHIT) gene is a candidate tumor suppressor gene.	Histidine	29-38	fragile histidine triad diadenosine triphosphatase	Homo sapiens	46-50
16985034-1	2006	AIM: The fragile histidine triad (FHIT) gene was discovered and proposed as a tumor suppressor gene for most human cancers.	Histidine	17-26	fragile histidine triad diadenosine triphosphatase	Homo sapiens	34-38
10745170-1	2000	The FHIT (fragile histidine triad) gene at chromosome 3p14.2 spans the FRA3B fragile site and encodes for a diadenosine triphosphate hydrolase-type protein.	Histidine	18-27	fragile histidine triad diadenosine triphosphatase	Homo sapiens	4-8
10745170-1	2000	The FHIT (fragile histidine triad) gene at chromosome 3p14.2 spans the FRA3B fragile site and encodes for a diadenosine triphosphate hydrolase-type protein.	Histidine	18-27	fragile histidine triad diadenosine triphosphatase	Homo sapiens	71-76
10745171-1	2000	Genetic alterations at the FHIT (fragile histidine triad) tumor suppressor gene have been found in various human cancers.	Histidine	41-50	fragile histidine triad diadenosine triphosphatase	Homo sapiens	27-31
16814409-4	2006	The 190th leucine of rpS3, and the 118th histidine and the 120th serine of nm23-H1 play key roles in the interaction of two proteins, respectively.	Histidine	41-50	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	75-82
10712555-2	2000	AB025251] and AtATP-PRT2), catalyzing the first step of the pathway of hisidine (His) biosynthesis.	Histidine	81-84	ATP phosphoribosyl transferase 2	Arabidopsis thaliana	14-24
21305248-5	2011	We stably transfected FADU cells with pSwitch and subsequently transiently separated pSwitch clones with pGene/V5-His-ETA.	Histidine	114-117	endothelin receptor type A	Homo sapiens	118-121
10671479-1	2000	Fhit, a member of the histidine triad superfamily of nucleotide-binding proteins, binds and cleaves diadenosine polyphosphates and functions as a tumor suppressor in human epithelial cancers.	Histidine	22-31	fragile histidine triad diadenosine triphosphatase	Homo sapiens	0-4
21250662-0	2011	Alteration of hydrogen bonding in the vicinity of histidine 48 disrupts millisecond motions in RNase A.	Histidine	50-59	ribonuclease A family member 1, pancreatic	Homo sapiens	95-102
10671535-3	2000	Amino acid sequence alignment of the 2-enoyl-CoA hydratase 2 domain in human MFE-2 with other MFE-2s reveals conserved protic residues: Tyr-347, Glu-366, Asp-370, His-406, Glu-408, Tyr-410, Asp-490, Tyr-505, Asp-510, His-515, Asp-517, and His-532.	Histidine	163-166	hydroxysteroid 17-beta dehydrogenase 4	Homo sapiens	77-82
10671535-3	2000	Amino acid sequence alignment of the 2-enoyl-CoA hydratase 2 domain in human MFE-2 with other MFE-2s reveals conserved protic residues: Tyr-347, Glu-366, Asp-370, His-406, Glu-408, Tyr-410, Asp-490, Tyr-505, Asp-510, His-515, Asp-517, and His-532.	Histidine	163-166	hydroxysteroid 17-beta dehydrogenase 4	Homo sapiens	94-99
10671535-3	2000	Amino acid sequence alignment of the 2-enoyl-CoA hydratase 2 domain in human MFE-2 with other MFE-2s reveals conserved protic residues: Tyr-347, Glu-366, Asp-370, His-406, Glu-408, Tyr-410, Asp-490, Tyr-505, Asp-510, His-515, Asp-517, and His-532.	Histidine	217-220	hydroxysteroid 17-beta dehydrogenase 4	Homo sapiens	77-82
10671535-3	2000	Amino acid sequence alignment of the 2-enoyl-CoA hydratase 2 domain in human MFE-2 with other MFE-2s reveals conserved protic residues: Tyr-347, Glu-366, Asp-370, His-406, Glu-408, Tyr-410, Asp-490, Tyr-505, Asp-510, His-515, Asp-517, and His-532.	Histidine	217-220	hydroxysteroid 17-beta dehydrogenase 4	Homo sapiens	94-99
10671535-3	2000	Amino acid sequence alignment of the 2-enoyl-CoA hydratase 2 domain in human MFE-2 with other MFE-2s reveals conserved protic residues: Tyr-347, Glu-366, Asp-370, His-406, Glu-408, Tyr-410, Asp-490, Tyr-505, Asp-510, His-515, Asp-517, and His-532.	Histidine	217-220	hydroxysteroid 17-beta dehydrogenase 4	Homo sapiens	77-82
10671535-3	2000	Amino acid sequence alignment of the 2-enoyl-CoA hydratase 2 domain in human MFE-2 with other MFE-2s reveals conserved protic residues: Tyr-347, Glu-366, Asp-370, His-406, Glu-408, Tyr-410, Asp-490, Tyr-505, Asp-510, His-515, Asp-517, and His-532.	Histidine	217-220	hydroxysteroid 17-beta dehydrogenase 4	Homo sapiens	94-99
10675363-4	2000	Because the single nucleotide polymorphism in FcgammaRIIA - which encodes histidine or arginine at position 131 - strongly influences IgG2 binding, we determined this polymorphism"s effect on CRP binding.	Histidine	74-83	Fc gamma receptor IIa	Homo sapiens	46-57
16717093-2	2006	An important feature of the nucleotide exchange is the structural rearrangement of EF-Tu in the EF-Tu.EF-Ts complex caused by insertion of Phe-81 of EF-Ts between His-84 and His-118 of EF-Tu.	Histidine	163-166	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	83-88
16717093-2	2006	An important feature of the nucleotide exchange is the structural rearrangement of EF-Tu in the EF-Tu.EF-Ts complex caused by insertion of Phe-81 of EF-Ts between His-84 and His-118 of EF-Tu.	Histidine	163-166	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	96-101
16717093-2	2006	An important feature of the nucleotide exchange is the structural rearrangement of EF-Tu in the EF-Tu.EF-Ts complex caused by insertion of Phe-81 of EF-Ts between His-84 and His-118 of EF-Tu.	Histidine	163-166	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	96-101
16717093-2	2006	An important feature of the nucleotide exchange is the structural rearrangement of EF-Tu in the EF-Tu.EF-Ts complex caused by insertion of Phe-81 of EF-Ts between His-84 and His-118 of EF-Tu.	Histidine	174-177	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	83-88
16717093-2	2006	An important feature of the nucleotide exchange is the structural rearrangement of EF-Tu in the EF-Tu.EF-Ts complex caused by insertion of Phe-81 of EF-Ts between His-84 and His-118 of EF-Tu.	Histidine	174-177	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	96-101
16717093-2	2006	An important feature of the nucleotide exchange is the structural rearrangement of EF-Tu in the EF-Tu.EF-Ts complex caused by insertion of Phe-81 of EF-Ts between His-84 and His-118 of EF-Tu.	Histidine	174-177	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	96-101
16717093-3	2006	In this study, the contribution of His-118 to nucleotide release was studied by pre-steady state kinetic analysis of nucleotide exchange in EF-Tu mutants in which His-118 was replaced by Ala or Glu.	Histidine	35-38	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	140-145
16717093-6	2006	The K(d) for GTP is increased by more than 40 times when His-118 is replaced with Glu, which may explain the inhibition by His-118 mutations of aminoacyl-tRNA binding to EF-Tu.	Histidine	57-60	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	170-175
21268659-0	2011	Histidines in the octapeptide repeat of PrPC react with PrPSc at an acidic pH.	Histidine	0-10	prion protein	Mus musculus	40-44
16698048-2	2006	Human FHIT (fragile histidine triad) gene is highly conserved gene whose loss of function may be important in the development and/or progression of various types of cancer.	Histidine	20-29	fragile histidine triad diadenosine triphosphatase	Homo sapiens	6-10
10648838-0	2000	Identification of the two histidine residues responsible for the inhibition by malonyl-CoA in peroxisomal carnitine octanoyltransferase from rat liver.	Histidine	26-35	carnitine O-octanoyltransferase	Rattus norvegicus	106-135
21268659-0	2011	Histidines in the octapeptide repeat of PrPC react with PrPSc at an acidic pH.	Histidine	0-10	prion protein	Mus musculus	56-61
16891471-6	2006	However, these cells did undergo apoptosis in response to another form of recombinant TRAIL, histidine-tagged TRAIL, suggesting differing contributions of DR4 and DR5 in the response to these two forms of TRAIL.	Histidine	93-102	TNF receptor superfamily member 10a	Homo sapiens	155-158
21268659-8	2011	However, modified PrP containing histidine to alanine substitutions within the octapeptide repeats was still converted to PrP(Sc) in N2a cells.	Histidine	33-42	prion protein	Mus musculus	18-21
16749776-11	2006	The fastest catalyst was the threonine mutant A3C ((Ac-His-Thr)8(Dap-His-Thr)4(Dap-His-Thr)2Dap-His-Thr-NH2), with kcat = 1.3 min(-1), kcat/k(uncat) = 90"000, KM = 160 microM for 8-bytyryloxypyrene 1,3,6-trisulfonate, corresponding to a rate acceleration of 18"000 per catalytic site and a 5-fold improvement over the original sequence A3.	Histidine	55-58	death associated protein	Homo sapiens	65-68
11015575-6	2000	Identification of the conserved catalytic triad (Ser(221&lt;/SUP &gt;, His(468), and Glu354)) and the SEDCLY motif places human macrophage CEH in the family of carboxylesterases.	Histidine	71-74	carboxylesterase 1	Homo sapiens	139-142
11015575-7	2000	A greater than 20-fold increase in CEH activity was observed when COS-1 and COS-7 cells were transiently transfected with an eukaryotic expression vector, pcDNA3.1/V5/His-TOPO, containing the cDNA for human macrophage CEH.	Histidine	167-170	carboxylesterase 1	Homo sapiens	35-38
16749776-11	2006	The fastest catalyst was the threonine mutant A3C ((Ac-His-Thr)8(Dap-His-Thr)4(Dap-His-Thr)2Dap-His-Thr-NH2), with kcat = 1.3 min(-1), kcat/k(uncat) = 90"000, KM = 160 microM for 8-bytyryloxypyrene 1,3,6-trisulfonate, corresponding to a rate acceleration of 18"000 per catalytic site and a 5-fold improvement over the original sequence A3.	Histidine	55-58	death associated protein	Homo sapiens	79-82
21268659-8	2011	However, modified PrP containing histidine to alanine substitutions within the octapeptide repeats was still converted to PrP(Sc) in N2a cells.	Histidine	33-42	prion protein	Mus musculus	122-125
10681067-5	2000	The cDNA of Cpr6 was cloned into a pRSET A-plasmid with an N-terminal 6 x histidine-tag (his-tag) and transformed into the BL21[DE3]pLysS strain.	Histidine	74-83	peptidylprolyl isomerase CPR6	Saccharomyces cerevisiae S288C	12-16
20857210-8	2011	In western blotting analysis, His(6)-tagged gcADSL protein expressed in Escherichia coli could be recognized not only by an anti-His(6)-tag monoclonal antibody but also by an anti-human ADSL polyclonal antibody, indicating immunological crossreactivity occurs between grass carp and human ADSL protein.	Histidine	30-33	adenylosuccinate lyase	Homo sapiens	46-50
10681067-5	2000	The cDNA of Cpr6 was cloned into a pRSET A-plasmid with an N-terminal 6 x histidine-tag (his-tag) and transformed into the BL21[DE3]pLysS strain.	Histidine	74-77	peptidylprolyl isomerase CPR6	Saccharomyces cerevisiae S288C	12-16
20857210-8	2011	In western blotting analysis, His(6)-tagged gcADSL protein expressed in Escherichia coli could be recognized not only by an anti-His(6)-tag monoclonal antibody but also by an anti-human ADSL polyclonal antibody, indicating immunological crossreactivity occurs between grass carp and human ADSL protein.	Histidine	30-33	adenylosuccinate lyase	Homo sapiens	186-190
16699185-1	2006	The structures of the PDI-related protein Wind (with a C-terminal His(6) tag) and the mutants Y53S, Y53F and Y55K have been determined and compared with the wild-type structure with the His(6) tag at the N-terminus.	Histidine	66-69	prolyl 4-hydroxylase subunit beta	Homo sapiens	22-25
21121676-0	2011	Mass spectrometry detection of histidine phosphorylation on NM23-H1.	Histidine	31-40	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	60-67
10636429-0	2000	Clinical phenotype associated with the arg141 his mutation in the X-linked retinoschisis gene.	Histidine	46-49	retinoschisin 1	Homo sapiens	66-88
21121676-3	2011	Here, we present a novel buffer system to show histidine phosphorylation of NM23-H1, the product of the first identified putative human metastasis suppressor gene (NME1), which catalyzes the transfer of the gamma-phosphate from nucleoside triphosphates to nucleoside diphosphates.	Histidine	47-56	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	76-83
21121676-3	2011	Here, we present a novel buffer system to show histidine phosphorylation of NM23-H1, the product of the first identified putative human metastasis suppressor gene (NME1), which catalyzes the transfer of the gamma-phosphate from nucleoside triphosphates to nucleoside diphosphates.	Histidine	47-56	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	164-168
22110750-5	2011	The data showed that SENP8 only cleaved the peptide bond beyond the di-glycine motif of CrNEDD8 and His-RUB1 was subsequently generated, confirming that SENP8 has exquisite specificity for CrNEDD8 but not CrUb.	Histidine	100-103	SUMO peptidase family member, NEDD8 specific	Homo sapiens	21-26
10620301-5	2000	These results are consistent with a model in which dimers constitute structural building blocks and where membrane-proximal and distal his-MoCA regions interact with different partners in membrane-bound arrays.	Histidine	135-138	dedicator of cytokinesis 3	Homo sapiens	139-143
10585483-4	1999	ArcB is a tripartite kinase, possessing a primary transmitter, a receiver, and a secondary transmitter domain that catalyzes the phosphorylation of ArcA via a His --&gt; Asp --&gt; His --&gt; Asp phosphorelay, as well as the dephosphorylation of ArcA-P by a reverse phosphorelay.	Histidine	181-184	arginine deiminase	Escherichia coli	148-152
16357063-1	2006	Histidine decarboxylase (HDC) is the enzyme that converts histidine to histamine, a bioamine that plays an important role in many physiological aspects including allergic responses, inflammation, neurotransmission, and gastric acid secretion.	Histidine	58-67	histidine decarboxylase	Homo sapiens	0-23
16357063-1	2006	Histidine decarboxylase (HDC) is the enzyme that converts histidine to histamine, a bioamine that plays an important role in many physiological aspects including allergic responses, inflammation, neurotransmission, and gastric acid secretion.	Histidine	58-67	histidine decarboxylase	Homo sapiens	25-28
16513785-5	2006	When D1-His(190) is protonated, corresponding to a thermally activated state, the calculated E(m)(Y(Z)) was +1216 mV, which is as high as the E(m) for P(D1/D2).	Histidine	8-11	programmed cell death 1	Homo sapiens	151-158
10585483-4	1999	ArcB is a tripartite kinase, possessing a primary transmitter, a receiver, and a secondary transmitter domain that catalyzes the phosphorylation of ArcA via a His --&gt; Asp --&gt; His --&gt; Asp phosphorelay, as well as the dephosphorylation of ArcA-P by a reverse phosphorelay.	Histidine	181-184	arginine deiminase	Escherichia coli	246-250
22110750-5	2011	The data showed that SENP8 only cleaved the peptide bond beyond the di-glycine motif of CrNEDD8 and His-RUB1 was subsequently generated, confirming that SENP8 has exquisite specificity for CrNEDD8 but not CrUb.	Histidine	100-103	SUMO peptidase family member, NEDD8 specific	Homo sapiens	153-158
10570056-1	1999	A vasoactive intestinal polypeptide (VIP) analog, acylated on the amino-terminal histidine by hexanoic acid (C(6)-VIP), behaved as a VPAC(2) preferring agonist in binding and functional studies on human VIP receptors, and radioiodinated C(6)-VIP was a suitable ligand for binding studies on wild-type and chimeric receptors.	Histidine	81-90	vasoactive intestinal peptide receptor 2	Homo sapiens	133-140
21912672-4	2011	The phosphoryl group is then transferred onto a histidine at the canonical phosphorylation site in AHP1.	Histidine	48-57	histidine-containing phosphotransmitter 1	Arabidopsis thaliana	99-103
10625469-1	1999	The proton-coupled Pho84 phosphate permease of Saccharomyces cerevisiae, overexpressed as a histidine-tagged chimera in Escherichia coli, was detergent-solubilized, purified, and reconstituted into proteoliposomes.	Histidine	92-101	phosphate transporter PHO84	Saccharomyces cerevisiae S288C	19-24
10569723-1	1999	The present paper reports two new alpha-globin chain variants: Hb Boghe [alpha58(E7)His-->Gln, alpha2] and Hb Charolles [alpha103(G10)His-->Tyr, alpha1].	Histidine	84-87	hemoglobin subunit alpha 2	Homo sapiens	34-46
10569723-1	1999	The present paper reports two new alpha-globin chain variants: Hb Boghe [alpha58(E7)His-->Gln, alpha2] and Hb Charolles [alpha103(G10)His-->Tyr, alpha1].	Histidine	134-137	hemoglobin subunit alpha 2	Homo sapiens	34-46
16821595-2	2006	The purpose of this study was to clarify whether the fragile histidine triad (FHIT) is their target gene in esophageal carcinogenesis as well as in multicentric carcinogenesis.	Histidine	61-70	fragile histidine triad diadenosine triphosphatase	Homo sapiens	78-82
16332725-6	2006	Individuals having ALDH2 Glu/Glu with ADH2 Arg+, ALDH2 Lys+ with ADH2 His/His and ALDH2 Lys+ with ADH2 Arg+ showed ORs of 0.10(0.04-0.21), 0.10 (0.06-0.19) and 1.36 (0.94-1.97), respectively, compared with ALDH2 Glu/Glu with ADH2 His/His.	Histidine	74-77	aldehyde dehydrogenase 2 family member	Homo sapiens	19-24
16332725-6	2006	Individuals having ALDH2 Glu/Glu with ADH2 Arg+, ALDH2 Lys+ with ADH2 His/His and ALDH2 Lys+ with ADH2 Arg+ showed ORs of 0.10(0.04-0.21), 0.10 (0.06-0.19) and 1.36 (0.94-1.97), respectively, compared with ALDH2 Glu/Glu with ADH2 His/His.	Histidine	74-77	aldehyde dehydrogenase 2 family member	Homo sapiens	49-54
16332725-6	2006	Individuals having ALDH2 Glu/Glu with ADH2 Arg+, ALDH2 Lys+ with ADH2 His/His and ALDH2 Lys+ with ADH2 Arg+ showed ORs of 0.10(0.04-0.21), 0.10 (0.06-0.19) and 1.36 (0.94-1.97), respectively, compared with ALDH2 Glu/Glu with ADH2 His/His.	Histidine	74-77	aldehyde dehydrogenase 2 family member	Homo sapiens	49-54
16332725-6	2006	Individuals having ALDH2 Glu/Glu with ADH2 Arg+, ALDH2 Lys+ with ADH2 His/His and ALDH2 Lys+ with ADH2 Arg+ showed ORs of 0.10(0.04-0.21), 0.10 (0.06-0.19) and 1.36 (0.94-1.97), respectively, compared with ALDH2 Glu/Glu with ADH2 His/His.	Histidine	74-77	aldehyde dehydrogenase 2 family member	Homo sapiens	49-54
10669907-3	1999	Intraperitoneal injection of L-histidine also resulted in an increase in rCBF in the hippocampus, in parallel with elevation of histamine content in the brain.	Histidine	29-40	CCAAT/enhancer binding protein zeta	Rattus norvegicus	73-77
21090702-9	2010	The protonation state of two histidines (His559 and His516) at the catalytic site of this flavoprotein is found to have a remarkable influence on the isotropic hyperfine coupling of one of the methyl groups on the neutral FAD radical, which is consistent with experimental findings in other flavoproteins (J. Biol.	Histidine	29-39	Suppressor of variegation 3-3	Drosophila melanogaster	90-102
10669907-4	1999	The increase in rCBF in the hippocampus induced by L-histidine was antagonized by both H1 and H2 antagonists (diphenhydramine, pyrilamine and zolantidine).	Histidine	51-62	CCAAT/enhancer binding protein zeta	Rattus norvegicus	16-20
16332725-6	2006	Individuals having ALDH2 Glu/Glu with ADH2 Arg+, ALDH2 Lys+ with ADH2 His/His and ALDH2 Lys+ with ADH2 Arg+ showed ORs of 0.10(0.04-0.21), 0.10 (0.06-0.19) and 1.36 (0.94-1.97), respectively, compared with ALDH2 Glu/Glu with ADH2 His/His.	Histidine	74-77	aldehyde dehydrogenase 2 family member	Homo sapiens	19-24
16332725-6	2006	Individuals having ALDH2 Glu/Glu with ADH2 Arg+, ALDH2 Lys+ with ADH2 His/His and ALDH2 Lys+ with ADH2 Arg+ showed ORs of 0.10(0.04-0.21), 0.10 (0.06-0.19) and 1.36 (0.94-1.97), respectively, compared with ALDH2 Glu/Glu with ADH2 His/His.	Histidine	74-77	aldehyde dehydrogenase 2 family member	Homo sapiens	49-54
16332725-6	2006	Individuals having ALDH2 Glu/Glu with ADH2 Arg+, ALDH2 Lys+ with ADH2 His/His and ALDH2 Lys+ with ADH2 Arg+ showed ORs of 0.10(0.04-0.21), 0.10 (0.06-0.19) and 1.36 (0.94-1.97), respectively, compared with ALDH2 Glu/Glu with ADH2 His/His.	Histidine	74-77	aldehyde dehydrogenase 2 family member	Homo sapiens	49-54
20889499-3	2010	The hPRL receptor binding interface contains four histidines whose protonation is hypothesized to regulate pH-dependent receptor recognition.	Histidine	50-60	prolactin receptor	Homo sapiens	4-17
16332725-6	2006	Individuals having ALDH2 Glu/Glu with ADH2 Arg+, ALDH2 Lys+ with ADH2 His/His and ALDH2 Lys+ with ADH2 Arg+ showed ORs of 0.10(0.04-0.21), 0.10 (0.06-0.19) and 1.36 (0.94-1.97), respectively, compared with ALDH2 Glu/Glu with ADH2 His/His.	Histidine	74-77	aldehyde dehydrogenase 2 family member	Homo sapiens	49-54
10608665-6	1999	In vitro experiments demonstrated that the putative signaling factors can transfer the phosphoryl group from His-80 of ZmHP2 to Asp-90 of ZmRRs.	Histidine	109-112	histidine-containing phosphotransfer protein 2	Zea mays	119-124
20690795-0	2010	Restoration of fragile histidine triad (FHIT) expression inhibits cell growth and induces apoptosis in cutaneous T-cell lymphoma cell line.	Histidine	23-32	fragile histidine triad diadenosine triphosphatase	Homo sapiens	40-44
10820843-2	1999	On the basis of calculating the constants of ionization it was supposed that in the case of actomyosin ATPase imidazole groups of two histidins had an essential role in reaction of ATP hydrolysis and in superprecipitation process--imidazol group of histidine and carboxyl group of asparagin acid.	Histidine	134-143	dynein axonemal heavy chain 8	Homo sapiens	103-109
10820843-2	1999	On the basis of calculating the constants of ionization it was supposed that in the case of actomyosin ATPase imidazole groups of two histidins had an essential role in reaction of ATP hydrolysis and in superprecipitation process--imidazol group of histidine and carboxyl group of asparagin acid.	Histidine	249-258	dynein axonemal heavy chain 8	Homo sapiens	103-109
16231322-1	2006	The fragile histidine triad (FHIT) gene is a frequent target of deletions in lung cancer.	Histidine	12-21	fragile histidine triad diadenosine triphosphatase	Homo sapiens	29-33
20690795-1	2010	To investigate the effects of fragile histidine triad (FHIT) restoration on cell proliferation and apoptosis in human cutaneous T-cell lymphoma cell line, Hut-78, in vitro and in nude mouse.	Histidine	38-47	fragile histidine triad diadenosine triphosphatase	Homo sapiens	55-59
20718765-9	2010	RESULTS: PAX8 gene sequencing revealed a heterozygous mutation that consists of the substitution of a histidine residue with a glutamine at position 55 of the PAX8 protein (H55Q).	Histidine	102-111	paired box 8	Homo sapiens	9-13
16755491-3	2006	The origin of this variant is a mutation in codon 47 (GAC --&gt; CAC) of the alpha2-globin gene, resulting in the replacement of asparagine by histidine during the translation process.	Histidine	143-152	hemoglobin subunit alpha 2	Homo sapiens	77-90
16519518-2	2006	To expedite functional and structural study of this enzyme, an expression plasmid encoding His-tagged human PMK has been constructed and recombinant enzyme isolated in an active, stable form.	Histidine	91-94	phosphomevalonate kinase	Homo sapiens	108-111
10508853-2	1999	SPP contains a signature zinc-binding motif, His-X-X-Glu-His, that places it in a metallopeptidase family which includes the mitochondrial processing peptidase.	Histidine	45-48	histocompatibility minor 13	Homo sapiens	0-3
10508853-2	1999	SPP contains a signature zinc-binding motif, His-X-X-Glu-His, that places it in a metallopeptidase family which includes the mitochondrial processing peptidase.	Histidine	57-60	histocompatibility minor 13	Homo sapiens	0-3
20718765-9	2010	RESULTS: PAX8 gene sequencing revealed a heterozygous mutation that consists of the substitution of a histidine residue with a glutamine at position 55 of the PAX8 protein (H55Q).	Histidine	102-111	paired box 8	Homo sapiens	159-163
10488113-1	1999	Histidine 30 in human manganese superoxide dismutase (MnSOD) is located at a site partially exposed to solvent with its side chain participating in a hydrogen-bonded network that includes the active-site residues Tyr(166) and Tyr(34) and extends to the manganese-bound solvent molecule.	Histidine	0-9	superoxide dismutase 2	Homo sapiens	22-52
16475789-6	2006	Using size exclusion chromatography and static light scattering to monitor trimer to 60-mer ratios in BAFF preparations, we find that 60-mer formation is pH-dependent and requires histidine 218 within the DE loop of BAFF.	Histidine	180-189	TNF superfamily member 13b	Homo sapiens	102-106
16475789-6	2006	Using size exclusion chromatography and static light scattering to monitor trimer to 60-mer ratios in BAFF preparations, we find that 60-mer formation is pH-dependent and requires histidine 218 within the DE loop of BAFF.	Histidine	180-189	TNF superfamily member 13b	Homo sapiens	216-220
10488113-1	1999	Histidine 30 in human manganese superoxide dismutase (MnSOD) is located at a site partially exposed to solvent with its side chain participating in a hydrogen-bonded network that includes the active-site residues Tyr(166) and Tyr(34) and extends to the manganese-bound solvent molecule.	Histidine	0-9	superoxide dismutase 2	Homo sapiens	54-59
21091672-8	2010	The mutation causes substitution of glutamine with histidine (p.Q331H) in the tumor necrosis factor homology domain of EDA.	Histidine	51-60	ectodysplasin A	Homo sapiens	119-122
10488113-2	1999	We have replaced His(30) with a series of amino acids and Tyr(166) with Phe in human MnSOD.	Histidine	17-20	superoxide dismutase 2	Homo sapiens	85-90
10473550-1	1999	Zinc increases the affinity of human growth hormone (hGH) for the human prolactin receptor (hPRLR) due to the coordination of one zinc ion involving Glu-174(hGH) and His-18(hGH).	Histidine	166-169	prolactin receptor	Homo sapiens	72-90
10473550-1	1999	Zinc increases the affinity of human growth hormone (hGH) for the human prolactin receptor (hPRLR) due to the coordination of one zinc ion involving Glu-174(hGH) and His-18(hGH).	Histidine	166-169	prolactin receptor	Homo sapiens	92-97
16428454-4	2006	We identified sites of Bas1p-DNA interactions upstream of 71 genes, many of which are involved in histidine and purine biosynthesis.	Histidine	98-107	Bas1p	Saccharomyces cerevisiae S288C	23-28
16428455-0	2006	The proline-histidine-rich CDK2/CDK4 interaction region of C/EBPalpha is dispensable for C/EBPalpha-mediated growth regulation in vivo.	Histidine	12-21	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	59-69
10518922-2	1999	The Pho84 protein has been modified by a gene fusion approach, yielding two different N-terminal His-tagged chimeras which can be expressed in Escherichia coli, purified and functionally reconstituted into defined proteoliposomes.	Histidine	97-100	phosphate transporter PHO84	Saccharomyces cerevisiae S288C	4-9
20977193-3	2010	The active site of this superfamily of enzymes includes a Ser1/Ser2(Tyr)/Lys1(His)/Lys2 tetrad in which Ser1 is a nucleophilic catalyst that becomes acylated in the formation of an acyl-enzyme intermediate.	Histidine	78-81	jagged canonical Notch ligand 2	Homo sapiens	63-67
10482317-8	1999	The apparent amino acid residue in position 143 (Pen alloantigen) of canine platelet beta3 is histidine compared with arginine in human beings.	Histidine	94-103	calcium channel, voltage-dependent, beta 3 subunit	Mus musculus	85-90
16428455-3	2006	In fetal liver it has been proposed that a short, centrally located, 15-amino-acid proline-histidine-rich region (PHR) of C/EBPalpha is responsible for the growth-inhibitory function of the protein through its ability to interact with CDK2 and CDK4, thereby inhibiting their activities.	Histidine	91-100	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	122-132
20977208-1	2010	The octapeptide angiotensin II (Ang II; Asp(1)-Arg(2)-Val(3)-Tyr(4)-Ile(5)-His(6)-Pro(7)-Phe(8)) is the primary active hormone of the renin/angiotensin system (RAS) and has been implicated in various cardiovascular diseases.	Histidine	75-78	angiogenin	Homo sapiens	32-35
20977208-2	2010	Numerous structure-activity relationship studies have identified Asp(1), Arg(2), and His(6) of Ang II to be critical for its biological activity and receptor binding.	Histidine	85-88	angiogenin	Homo sapiens	95-98
20948543-3	2010	Nanos has two conserved Cys-Cys-His-Cys zinc-finger motifs that are indispensable for its function.	Histidine	32-35	nanos homolog 3	Danio rerio	0-5
16884532-6	2006	The UGT1A424Thr/48Leu and UGT1A424Pro/48Val variants were generated by site-directed mutagenesis of the pcDNA3.1/V5-His-TOPO plasmid expressing wild-type UGT1A424Pro/48Leu.	Histidine	116-119	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	4-9
16884532-6	2006	The UGT1A424Thr/48Leu and UGT1A424Pro/48Val variants were generated by site-directed mutagenesis of the pcDNA3.1/V5-His-TOPO plasmid expressing wild-type UGT1A424Pro/48Leu.	Histidine	116-119	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	26-31
16884532-6	2006	The UGT1A424Thr/48Leu and UGT1A424Pro/48Val variants were generated by site-directed mutagenesis of the pcDNA3.1/V5-His-TOPO plasmid expressing wild-type UGT1A424Pro/48Leu.	Histidine	116-119	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	26-31
10446255-7	1999	Bacterially expressed, purified His-C/EBPalpha is able to disrupt E2F/p107 complexes that are observed at earlier stages of 3T3-L1 differentiation.	Histidine	32-35	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	36-46
10446255-7	1999	Bacterially expressed, purified His-C/EBPalpha is able to disrupt E2F/p107 complexes that are observed at earlier stages of 3T3-L1 differentiation.	Histidine	32-35	RB transcriptional corepressor like 1	Mus musculus	70-74
20679445-6	2010	Cy2-labeled SitC-His colocalized specifically with TLR2 in MKs and was also internalized in TLR2 knockout MKs, suggesting a TLR2-independent uptake.	Histidine	17-20	toll-like receptor 2	Mus musculus	51-55
10441372-3	1999	To better understand the molecular mechanism of the KIR-mediated inhibitory signal transduction, we developed an in vitro assay system using a purified His-tag fusion protein of KIR cytoplasmic tail (His-CytKIR) and Jurkat T cell lysates.	Histidine	152-155	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	52-55
10441372-3	1999	To better understand the molecular mechanism of the KIR-mediated inhibitory signal transduction, we developed an in vitro assay system using a purified His-tag fusion protein of KIR cytoplasmic tail (His-CytKIR) and Jurkat T cell lysates.	Histidine	152-155	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	178-181
16331989-3	2005	Human IAPP contains a single histidine at position 18.	Histidine	29-38	islet amyloid polypeptide	Homo sapiens	6-10
20679445-6	2010	Cy2-labeled SitC-His colocalized specifically with TLR2 in MKs and was also internalized in TLR2 knockout MKs, suggesting a TLR2-independent uptake.	Histidine	17-20	toll-like receptor 2	Mus musculus	92-96
16267770-2	2005	METHODS: Fc gamma RIIa mutation at amino acid position 131 (arginine or histidine) was detected by polymerase chain reaction, and in vitro cultures for parasites were used to assess the invasion rate.	Histidine	72-81	Fc gamma receptor IIa	Homo sapiens	9-22
10417309-9	1999	A histidine residue at position 140 in rat liver CPT I has been indicated to be important for inhibition by malonyl-CoA.	Histidine	2-11	carnitine palmitoyltransferase 1B	Rattus norvegicus	49-54
20679445-6	2010	Cy2-labeled SitC-His colocalized specifically with TLR2 in MKs and was also internalized in TLR2 knockout MKs, suggesting a TLR2-independent uptake.	Histidine	17-20	toll-like receptor 2	Mus musculus	92-96
20715794-6	2010	Zn(II)-loaded R246H GLX2-1 enzyme bound 2 equiv of Zn(II), and (1)H NMR spectra of the Co(II)-substituted analogue of this enzyme strongly suggest that the introduced histidine binds to Co(II).	Histidine	167-176	hydroxyacylglutathione hydrolase	Homo sapiens	20-24
20878579-1	2010	OBJECTIVE: To investigate the effect of fragile histidine triad (FHIT) gene transfection on human colorectal cancer cell line SW480 through up-regulation of caspase-8 expression.	Histidine	48-57	fragile histidine triad diadenosine triphosphatase	Homo sapiens	65-69
10427728-1	1999	To investigate the functional role of an invariant histidine residue in Trigonopsis variabilis D-amino acid oxidase (DAAO), a set of mutant enzymes with replacement of the histidine residue at position 324 was constructed and their enzymatic properties were examined.	Histidine	51-60	D-amino acid oxidase	Sus scrofa	117-121
10427728-1	1999	To investigate the functional role of an invariant histidine residue in Trigonopsis variabilis D-amino acid oxidase (DAAO), a set of mutant enzymes with replacement of the histidine residue at position 324 was constructed and their enzymatic properties were examined.	Histidine	172-181	D-amino acid oxidase	Sus scrofa	117-121
16361827-7	2005	This is the first report to characterize AQP2 mutations in Korean patients with autosomal recessive CNDI, and expands the spectrum of AQP2 mutations by reporting two novel mutation, 70Ala (GCC) to Asp (GAC) and 187Arg (CGC) to His (CAC).	Histidine	227-230	guanylate cyclase 2C	Homo sapiens	189-192
16388371-3	2005	Analysis of presenilin-1 gene revealed a missense mutation at codon 166, leading to the substitution from leucine to histidine.	Histidine	117-126	presenilin 1	Homo sapiens	12-24
10424441-4	1999	To better understand the molecular interaction between KIR and TCR zeta-chain, we generated a His-tag fusion protein of a p70 KIR cytoplasmic tail (His-CytKIR) and used this protein to coprecipitate TCR zeta-chain from Jurkat T cells.	Histidine	94-97	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	55-58
10424441-4	1999	To better understand the molecular interaction between KIR and TCR zeta-chain, we generated a His-tag fusion protein of a p70 KIR cytoplasmic tail (His-CytKIR) and used this protein to coprecipitate TCR zeta-chain from Jurkat T cells.	Histidine	94-97	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	126-129
10424441-4	1999	To better understand the molecular interaction between KIR and TCR zeta-chain, we generated a His-tag fusion protein of a p70 KIR cytoplasmic tail (His-CytKIR) and used this protein to coprecipitate TCR zeta-chain from Jurkat T cells.	Histidine	148-151	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	55-58
10424441-4	1999	To better understand the molecular interaction between KIR and TCR zeta-chain, we generated a His-tag fusion protein of a p70 KIR cytoplasmic tail (His-CytKIR) and used this protein to coprecipitate TCR zeta-chain from Jurkat T cells.	Histidine	148-151	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	126-129
20878579-1	2010	OBJECTIVE: To investigate the effect of fragile histidine triad (FHIT) gene transfection on human colorectal cancer cell line SW480 through up-regulation of caspase-8 expression.	Histidine	48-57	caspase 8	Homo sapiens	157-166
20497104-4	2010	D-Lys6-GnRH and [Asn1-Val5]-angiotensin II were modified at their histidine side chain within the peptide, whilst IGF-1 (1-3) was modified at the C-terminal glutamic acid residue.	Histidine	66-75	gonadotropin releasing hormone 1	Homo sapiens	7-11
19965803-5	2010	The presence of an arginine instead of a histidine residue at amino acid position 131 (H131R) in the extracellular domain of FcgammaRIIa reduces the affinity of the receptor for IgG(2) and IgG(3) isotypes but increases the binding activity for C reactive protein (CRP).	Histidine	41-50	Fc gamma receptor IIa	Homo sapiens	125-136
10318835-3	1999	Comparison of primary sequence to that of lipoprotein and hepatic lipase reveals conservation of the serine, aspartic acid, and histidine catalytic residues as well as the 10 cysteine residues involved in disulfide bond formation.	Histidine	128-137	lipase C, hepatic type	Homo sapiens	58-72
10220559-8	1999	A histidine residue in the third extracellular loop of Kv1.5 (H452) accounts for the difference in pH sensitivity between the Kv1.5 and Kv1.2 channels.	Histidine	2-11	potassium voltage-gated channel subfamily A member 4 L homeolog	Xenopus laevis	55-60
10220559-8	1999	A histidine residue in the third extracellular loop of Kv1.5 (H452) accounts for the difference in pH sensitivity between the Kv1.5 and Kv1.2 channels.	Histidine	2-11	potassium voltage-gated channel subfamily A member 4 L homeolog	Xenopus laevis	126-131
16175316-7	2005	Similarly, the risk associated with a long duration (&gt;or=30 years) of menstruation also substantially differed by the SULT1A1 genotype (p for interaction = 0.05), with an OR of 4.0 (95% CI = 1.3-12.8) for women with the Arg/His genotype and 1.4 (0.8-2.5) for women with the Arg/Arg genotype.	Histidine	227-230	sulfotransferase family 1A member 1	Homo sapiens	121-128
16106046-9	2005	We propose that one disulfide bond between C65 and C89 and free cysteine residues at C330 and C371 and the triad, serine-198, aspartic acid-360, and histidine-392, are required for the full expression of mLPLA2 activity.	Histidine	149-158	phospholipase A2, group XV	Mus musculus	204-210
10220559-9	1999	Mutation of histidine H452 to a glutamine residue in Kv1.5 yields a channel that no longer shows enhanced inactivation with acidification.	Histidine	12-21	potassium voltage-gated channel subfamily A member 4 L homeolog	Xenopus laevis	53-58
20162441-2	2010	C(2)H(2) (Cys-Cys-His-His motif) ZFPs are the most abundant proteins among the founding members of the ZFP super family in eukaryotes.	Histidine	18-21	zinc finger with KRAB and SCAN domains 7	Homo sapiens	33-36
10206968-2	1999	Our previous studies identified a pore histidine as a major component of the acid activation mechanism of the potato guard cell K+ channel KST1 (1).	Histidine	39-48	solute carrier family 5 member 11	Homo sapiens	139-143
10206968-4	1999	In both channels, KST1 and KAT1, aspartate mutants in the K+ channel consensus sequence GYGD adjacent to the histidine (KST1-D269N and KAT1-D265N) were inhibited by a rise in the extracellular proton concentration.	Histidine	109-118	solute carrier family 5 member 11	Homo sapiens	18-22
10206968-4	1999	In both channels, KST1 and KAT1, aspartate mutants in the K+ channel consensus sequence GYGD adjacent to the histidine (KST1-D269N and KAT1-D265N) were inhibited by a rise in the extracellular proton concentration.	Histidine	109-118	solute carrier family 5 member 11	Homo sapiens	120-124
10206968-7	1999	From our electrophysiological studies on channel mutants with respect to the pore histidine as well as the aspartate, we conclude that the common proton-supported shift in the voltage dependence of KST1 and KAT1 is based on distinct molecular elements.	Histidine	82-91	solute carrier family 5 member 11	Homo sapiens	198-202
10213617-7	1999	In a mutant P-gp (E875C) that gave about equal amounts of both topologies, only the C-Half (CL3-cyt) could be recovered by nickel chromatography after coexpression with the histidine-tagged N-Half P-gp.	Histidine	173-182	adhesion G protein-coupled receptor L3	Homo sapiens	92-95
16141202-3	2005	We confirm here that the Tdp1 catalytic cycle involves a covalent reaction intermediate in which a histidine residue is connected to a DNA 3"-phosphate through a phosphoamide linkage.	Histidine	99-108	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	25-29
20445167-3	2010	Here, we describe an analysis of linkage in a two-generation pedigree leading to the identification of a rare functional mutation in the HDC gene encoding L-histidine decarboxylase, the rate-limiting enzyme in histamine biosynthesis.	Histidine	155-166	histidine decarboxylase	Homo sapiens	137-140
16162016-1	2005	Thyrotropin-releasing hormone (TRH) analogues in which the C-2 position of the imidazole ring of the centrally placed histidine residue is substituted with various alkyl groups were synthesized and studied as agonists for TRH receptor subtype 1 (TRH-R1) and subtype 2 (TRH-R2).	Histidine	118-127	thyrotropin releasing hormone	Homo sapiens	0-29
16162016-1	2005	Thyrotropin-releasing hormone (TRH) analogues in which the C-2 position of the imidazole ring of the centrally placed histidine residue is substituted with various alkyl groups were synthesized and studied as agonists for TRH receptor subtype 1 (TRH-R1) and subtype 2 (TRH-R2).	Histidine	118-127	thyrotropin releasing hormone	Homo sapiens	31-34
10222643-5	1999	The molecular analysis of the cathodally shifted APOJ*2 allele on IEF gels revealed an amino acid substitution of asparagine by histidine resulting from a missense mutation (A--&gt;C) at codon 317 in exon 7.	Histidine	128-137	clusterin	Homo sapiens	49-53
20005226-3	2010	In the lamprey, a most basal vertebrate, the third amino acid of the "DRY" in lamprey (lGnRHR-1) is His, while it is most often His/Gln in the type II GnRHR.	Histidine	100-103	gonadotropin releasing hormone receptor	Homo sapiens	88-93
10026163-5	1999	This difference is consistent with preferential binding of Cu(II) in Hb A0 to a high affinity site involving His-beta2, which is ineffective in promoting electron exchange between Cu(II) and the beta heme iron.	Histidine	109-112	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	113-118
20033885-5	2010	Recent work in breast carcinoma has implicated the histidine variant of CASP8 D302H (rs1045485) as a protective risk allele.	Histidine	51-60	caspase 8	Homo sapiens	72-77
9915818-0	1999	Effects of the location of distal histidine in the reaction of myoglobin with hydrogen peroxide.	Histidine	34-43	myoglobin	Physeter catodon	63-72
20033885-10	2010	CONCLUSION: These results suggest that histidine variant of CASP8 D302H is a protective allele for aggressive PCa with potential utility for identification of patients at differential risk for this clinically significant phenotype.	Histidine	39-48	caspase 8	Homo sapiens	60-65
10025963-0	1999	Possible role for ligand binding of histidine 81 in the second transmembrane domain of the rat prostaglandin F2alpha receptor.	Histidine	36-45	prostaglandin F receptor	Rattus norvegicus	95-125
10025963-6	1999	The aim of the current study was to analyze the potential role in ligand binding of His-81 in the second transmembrane domain of the rat PGF2alpha receptor, which is conserved among all PGF2alpha receptors from different species.	Histidine	84-87	prostaglandin F receptor	Rattus norvegicus	137-155
20368109-9	2010	Western blot showed recombinant protein can specificly reacted with anti-human HMGB1 polyclonal antibody and anti-His-Tag polyclonal antibody.The purpose protein was found more than 90% after purified, and can effectively inhibit the production of BAFF, IFN-gamma and TNF-alpha in monocyte which were induced by IC.	Histidine	114-117	high mobility group box 1	Homo sapiens	79-84
10025963-15	1999	The data indicate that the His-81 in the second transmembrane domain of the PGF2alpha receptor in concert with Arg-291 in the seventh transmembrane domain may be involved in ligand binding, most likely not by ionic interaction with the prostaglandin"s carboxyl group but rather as a hydrogen bond donor.	Histidine	27-30	prostaglandin F receptor	Homo sapiens	76-94
20368109-9	2010	Western blot showed recombinant protein can specificly reacted with anti-human HMGB1 polyclonal antibody and anti-His-Tag polyclonal antibody.The purpose protein was found more than 90% after purified, and can effectively inhibit the production of BAFF, IFN-gamma and TNF-alpha in monocyte which were induced by IC.	Histidine	114-117	TNF superfamily member 13b	Homo sapiens	248-252
20167204-6	2010	These results collectively suggest that the third C(3)H zinc finger, Cys-His motif and C(3)HC(4) RING zinc finger are indispensable for the anti-neurogenic activity of mkrn2.	Histidine	73-76	E3 ubiquitin-protein ligase makorin-2	Xenopus laevis	168-173
9926922-1	1999	Aberrant FHIT mRNA transcripts are present in malignant and normal haematopoiesis, but absence of FHIT protein is restricted to leukaemia Alterations of the recently cloned fragile histidine triad (FHIT) gene at chromosome 3p14.2 are frequent in a variety of solid tumours and cancer cell lines.	Histidine	181-190	fragile histidine triad diadenosine triphosphatase	Homo sapiens	9-13
9888182-1	1999	The complexation between an 18-residue zinc finger peptide of CCHC type (CCHC = Cys-X2-Cys-X4-His-X4-Cys, X = variable amino acid) from the gag protein p55 of human immunodeficiency virus type 1 (HIV-1) and various transition metal ions was studied by means of circular dichroism spectroscopy and matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS).	Histidine	94-97	Pr55(Gag)	Human immunodeficiency virus 1	140-143
20117128-8	2010	Surprisingly, mutation of a conserved catalytic histidine residue in the core sirtuin domain not only abrogates SIRT6 enzymatic activity but also leads to impaired chromatin association in cells.	Histidine	48-57	sirtuin 6	Homo sapiens	112-117
10619374-5	1999	The aim of this study was to elucidate whether central injection of substituted GLP-1 in which N-terminal histidine of mammalian GLP-1 (7-36) amide was replaced with tyrosine, inhibits food intake in the chick.	Histidine	106-115	glucagon like peptide 1 receptor	Homo sapiens	80-85
10619374-5	1999	The aim of this study was to elucidate whether central injection of substituted GLP-1 in which N-terminal histidine of mammalian GLP-1 (7-36) amide was replaced with tyrosine, inhibits food intake in the chick.	Histidine	106-115	glucagon like peptide 1 receptor	Homo sapiens	129-134
10619374-7	1999	These results indicate that N-terminal histidine of GLP-1 (7-36) amide is important for efficacy, but not essential for its bioactivity.	Histidine	39-48	glucagon	Gallus gallus	52-57
20158486-4	2010	D-Lys6-GnRH and [Asn1-Val5]-angiotensin II were modified at their histidine side chain within the peptide, whilst IGF-1 (1-3) was modified at the C-terminal glutamic acid residue.	Histidine	66-75	gonadotropin releasing hormone 1	Homo sapiens	7-11
19730990-3	2010	Fragile Histidine Triad (FHIT) has been shown to play a pivotal role in carcinogenesis.	Histidine	8-17	fragile histidine triad diadenosine triphosphatase	Homo sapiens	25-29
10386039-4	1999	In this work is analysed endonuclease activity of recombinant pancreatic RNase A (K7H), that in position seven instead of a lysine there is a histidine, amino acid residue that participates in main catalytic site p1.	Histidine	142-151	ribonuclease A family member 1, pancreatic	Homo sapiens	73-80
10386039-6	1999	Results of this investigation have shown that substitution of lysine by histidine in position seven of RNase A has produced total deletion of p2 subsite, and K7H has lost endonuclease activity, and has become exonuclease.	Histidine	72-81	ribonuclease A family member 1, pancreatic	Homo sapiens	103-110
10413210-4	1999	The allele FcgammaRIIA-H131 encodes a receptor with a histidine at the 131 amino acid position; the other allele FcgammaRIIA-R131 encodes an arginine.	Histidine	54-63	Fc gamma receptor IIa	Homo sapiens	11-22
19876776-4	2010	Recombinant histidine-tagged S. xylosus lipase was purified by affinity chromatography in an HPLC system.	Histidine	12-21	YSIRK-type signal peptide-containing protein	Staphylococcus xylosus	40-46
10604277-2	1999	Biochemical characterization of MMPs, a family of neutral proteolytic enzymes involved in extracellular matrix modeling, included determination of substrate specificity and Ca+2 dependency, as well as the effects of protease inactivators, carboxylic and His (histidine) residue modifiers, and antibiotics.	Histidine	259-268	matrix metallopeptidase 2	Homo sapiens	32-36
20946858-5	2010	In addition, experimental protocols for studying the consequences of heterotrimeric G protein activation via NDPK/Gbetagamma mediated phosphorelay, the regulation of ACL activity and of KCa3.1 conductivity by histidine phosphorylation will be presented.	Histidine	209-218	potassium calcium-activated channel subfamily N member 4	Homo sapiens	186-192
20061554-4	2010	The interactions between DDB1 and COP1, SPA1, and SPA3 were disrupted by mutations in the WDXR motifs of MBP-COP1, His-SPA1, and His-SPA3.	Histidine	115-118	Transducin/WD40 repeat-like superfamily protein	Arabidopsis thaliana	34-38
9857030-7	1998	A chimeric tetramer composed of three ubiquitins and one histidine-tagged NEDD8 binds to the 26 S proteasome with an affinity similar to that of tetraubiquitin.	Histidine	57-66	NEDD8 ubiquitin like modifier	Homo sapiens	74-79
20061554-4	2010	The interactions between DDB1 and COP1, SPA1, and SPA3 were disrupted by mutations in the WDXR motifs of MBP-COP1, His-SPA1, and His-SPA3.	Histidine	115-118	SPA (suppressor of phyA-105) protein family	Arabidopsis thaliana	40-44
20061554-4	2010	The interactions between DDB1 and COP1, SPA1, and SPA3 were disrupted by mutations in the WDXR motifs of MBP-COP1, His-SPA1, and His-SPA3.	Histidine	115-118	SPA (suppressor of phyA-105) protein family	Arabidopsis thaliana	119-123
9830034-2	1998	Under those conditions, the tripartite sensor kinase ArcB undergoes autophosphorylation at the expense of ATP and subsequently transphosphorylates its cognate response regulator ArcA through a His --&gt; Asp --&gt; His --&gt; Asp phosphorelay pathway.	Histidine	193-196	arginine deiminase	Escherichia coli	178-182
9830034-2	1998	Under those conditions, the tripartite sensor kinase ArcB undergoes autophosphorylation at the expense of ATP and subsequently transphosphorylates its cognate response regulator ArcA through a His --&gt; Asp --&gt; His --&gt; Asp phosphorelay pathway.	Histidine	215-218	arginine deiminase	Escherichia coli	178-182
20061554-4	2010	The interactions between DDB1 and COP1, SPA1, and SPA3 were disrupted by mutations in the WDXR motifs of MBP-COP1, His-SPA1, and His-SPA3.	Histidine	129-132	Transducin/WD40 repeat-like superfamily protein	Arabidopsis thaliana	34-38
9824201-2	1998	Recently, the FHIT (fragile histidine triad) gene was identified in this part of chromosome 3 as a candidate suppressor gene, and abnormal transcripts of this gene have been observed in various human tumors, including breast tumors.	Histidine	28-37	fragile histidine triad diadenosine triphosphatase	Homo sapiens	14-18
20061554-4	2010	The interactions between DDB1 and COP1, SPA1, and SPA3 were disrupted by mutations in the WDXR motifs of MBP-COP1, His-SPA1, and His-SPA3.	Histidine	129-132	SPA (suppressor of phyA-105) protein family	Arabidopsis thaliana	40-44
9822821-4	1998	The same combined approach, used to study histidine biosynthesis gene expression, showed that HIS1 and HIS4 expression is co-regulated with purine biosynthesis genes whereas HIS2, HIS3, HIS5 and HIS6 expression is not.	Histidine	42-51	ATP phosphoribosyltransferase	Saccharomyces cerevisiae S288C	94-98
19320425-6	2009	Cd(2+) and Msh2-Msh6 interactions involve cysteine sulfhydryl groups, and the high Cd(2+):Msh2-Msh6 ratio implicates other ligands such as histidine, aspartate, glutamate, and the peptide backbone as well.	Histidine	139-148	mutS homolog 2	Homo sapiens	90-94
9744812-4	1998	The present report may be related to the recent finding that human Fhit (fragile histidine triad) protein, encoded by the FHIT putative tumor suppressor gene, is a typical dinucleoside 5",5""-P1,P3-triphosphate (Ap3A) hydrolase (EC 3.6.1.29).	Histidine	81-90	fragile histidine triad diadenosine triphosphatase	Homo sapiens	67-71
19751438-1	2009	BACKGROUND: The expression of a fragile histidine triad (FHIT) protein is lost in stomach tumors.	Histidine	40-49	fragile histidine triad diadenosine triphosphatase	Homo sapiens	57-61
9744812-4	1998	The present report may be related to the recent finding that human Fhit (fragile histidine triad) protein, encoded by the FHIT putative tumor suppressor gene, is a typical dinucleoside 5",5""-P1,P3-triphosphate (Ap3A) hydrolase (EC 3.6.1.29).	Histidine	81-90	fragile histidine triad diadenosine triphosphatase	Homo sapiens	122-126
9744812-4	1998	The present report may be related to the recent finding that human Fhit (fragile histidine triad) protein, encoded by the FHIT putative tumor suppressor gene, is a typical dinucleoside 5",5""-P1,P3-triphosphate (Ap3A) hydrolase (EC 3.6.1.29).	Histidine	81-90	fragile histidine triad diadenosine triphosphatase	Homo sapiens	212-227
9699676-1	1998	Previous studies suggested that the FHIT (fragile histidine triad) gene on 3p14.2 might be involved in the development of esophageal squamous cell carcinomas, but the mechanisms for inactivating the gene have not been fully revealed.	Histidine	50-59	fragile histidine triad diadenosine triphosphatase	Homo sapiens	36-40
19553567-2	2009	Homology models constructed on the basis of the experimental structures of Escherichia coli AmtB and Nitrosomonas europaea Rh50 indicated a channel structure for human RhA (RhAG), RhB (RhBG), and RhC (RhCG) glycoproteins in which external and internal vestibules are linked by a pore containing two strictly conserved histidines.	Histidine	318-328	Rh family C glycoprotein	Homo sapiens	196-199
9683496-4	1998	Results of recent in vitro studies revealed multistep His-to-Asp phosphotransfer circuitry in the ArcB-ArcA signaling system.	Histidine	54-57	arginine deiminase	Escherichia coli	103-107
9683496-7	1998	Nonetheless, the ArcB mutant lacking this crucial His-717 site does not necessarily exhibit a null phenotype with respect to ArcB-ArcA signaling.	Histidine	50-53	arginine deiminase	Escherichia coli	130-134
9693743-14	1998	Conserved histidine residues in the CcsA and Ccs1 may serve as ligands to the heme iron.	Histidine	10-19	copper chaperone CCS1	Saccharomyces cerevisiae S288C	45-49
19553567-2	2009	Homology models constructed on the basis of the experimental structures of Escherichia coli AmtB and Nitrosomonas europaea Rh50 indicated a channel structure for human RhA (RhAG), RhB (RhBG), and RhC (RhCG) glycoproteins in which external and internal vestibules are linked by a pore containing two strictly conserved histidines.	Histidine	318-328	Rh family C glycoprotein	Homo sapiens	201-205
19415463-1	2009	The guest editor (AM) provides his perspective on the most recent advances on nucleoside diphosphate kinase (NDPK, otherwise known as AWD or NM23) showcasing phospho-histidine biochemistry and its impact on diverse pathology when disordered.	Histidine	166-175	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	141-145
9636708-7	1998	Cross-linking, co-immunoprecipitation, and histidine tagging experiments showed that YccA11 as well as YccA can associate with both the FtsH and the HflKC proteins.	Histidine	43-52	YccA	Escherichia coli	85-89
9582326-10	1998	In contrast, complex p38.p37.p36-his displayed no ATPase, suggesting that p40 is essential for ATPase activity.	Histidine	33-36	nucleoporin 37	Homo sapiens	25-28
19479888-1	2009	The fragile histidine triad gene (human FHIT, mouse Fhit) has been shown to act as a tumor suppressor gene.	Histidine	12-21	fragile histidine triad diadenosine triphosphatase	Homo sapiens	40-44
9582326-10	1998	In contrast, complex p38.p37.p36-his displayed no ATPase, suggesting that p40 is essential for ATPase activity.	Histidine	33-36	interleukin 9	Homo sapiens	74-77
9582326-11	1998	Although p38 was not required for ATPase activity, the activity of the p40-his.p38.p37.	Histidine	75-78	interleukin 9	Homo sapiens	71-74
9582326-11	1998	Although p38 was not required for ATPase activity, the activity of the p40-his.p38.p37.	Histidine	75-78	nucleoporin 37	Homo sapiens	83-86
19289096-3	2009	In this communication, two plant lines were produced using the psbo1 mutant as transgenic host, which contained an N-terminally histidine(6)-tagged PsbO-1 protein.	Histidine	128-137	PS II oxygen-evolving complex 1	Arabidopsis thaliana	63-68
9582326-12	1998	p36 complex was more salt-resistant than that of the p40-his.p37.p36 complex.	Histidine	57-60	interleukin 9	Homo sapiens	53-56
9582326-12	1998	p36 complex was more salt-resistant than that of the p40-his.p37.p36 complex.	Histidine	57-60	nucleoporin 37	Homo sapiens	61-64
19289096-3	2009	In this communication, two plant lines were produced using the psbo1 mutant as transgenic host, which contained an N-terminally histidine(6)-tagged PsbO-1 protein.	Histidine	128-137	PS II oxygen-evolving complex 1	Arabidopsis thaliana	148-154
19289096-6	2009	Examination of the Photosystem II closure kinetics demonstrated that the defective double reduction of Q(B) and the delayed exchange of Q(B)H(2) with the plastoquinone pool which were observed during the characterization of the psbo1 mutant were effectively restored to wild-type levels by the His(6)-tagged PsbO-1 protein.	Histidine	294-297	PS II oxygen-evolving complex 1	Arabidopsis thaliana	228-233
9553063-13	1998	SBCRK and histidine-tagged CRK3 activities were inhibited by the purine analogue olomoucine with an IC50 of 28 and 42 microM, respectively, 5-6-fold higher than human p34(cdc2)/cyclinB.	Histidine	10-19	cyclin H	Homo sapiens	167-170
19457868-2	2009	In this group of enzymes, the FAD cofactor is linked via its 8alpha-methyl group and the C-6 atom to conserved histidine and cysteine residues, His-104 and Cys-166 for BBE, respectively.	Histidine	111-120	complement C6	Homo sapiens	89-92
9546397-3	1998	The 2.6 A crystal structure of HFE reveals the locations of hemochromatosis mutations and a patch of histidines that could be involved in pH-dependent interactions.	Histidine	101-111	homeostatic iron regulator	Homo sapiens	31-34
19457868-2	2009	In this group of enzymes, the FAD cofactor is linked via its 8alpha-methyl group and the C-6 atom to conserved histidine and cysteine residues, His-104 and Cys-166 for BBE, respectively.	Histidine	144-147	complement C6	Homo sapiens	89-92
9521166-1	1998	BACKGROUND: The fragile histidine triad (FHIT) gene at chromosome 3p14.2 has been proposed to be a candidate tumor suppressor gene in human cancers.	Histidine	24-33	fragile histidine triad diadenosine triphosphatase	Homo sapiens	41-45
19401904-1	2009	PURPOSE: To study whether fragile histidine triad (Fhit) prevents IR-induced hypoxanthineguanine phosphoribosyltransferase (HPRT) mutation and whether Fhit plays any role in preventing HPRT mutation through low dose-induced adaptive response.	Histidine	34-43	fragile histidine triad diadenosine triphosphatase	Homo sapiens	51-55
9539420-6	1998	Recessive mutations in these two genes led to highly unregulated GCN4 expression and to derepressed transcription of genes in the histidine biosynthetic pathway under GCN4 control.	Histidine	130-139	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	167-171
19401904-1	2009	PURPOSE: To study whether fragile histidine triad (Fhit) prevents IR-induced hypoxanthineguanine phosphoribosyltransferase (HPRT) mutation and whether Fhit plays any role in preventing HPRT mutation through low dose-induced adaptive response.	Histidine	34-43	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	124-128
19131950-5	2009	In addition, microdeletions at 3p14.2 were detected in 3 (5%) cSCCs, implicating the fragile histidine triad (FHIT) gene as a possible target for inactivation.	Histidine	93-102	fragile histidine triad diadenosine triphosphatase	Homo sapiens	110-114
9473467-4	1998	We have expressed the murine BST-1 in yeast as a 6 x His-tagged secreted protein.	Histidine	53-56	bone marrow stromal cell antigen 1	Mus musculus	29-34
19339245-7	2009	The positions of the cysteine/histidine residues in this region bear similarity to parkin RING1 and RING2 domains, as well as other E3 ligase RING domains.	Histidine	30-39	ring finger protein 1	Homo sapiens	90-95
9490854-5	1998	Removal of K+o had a similar effect on current through Kv1.3 when the histidine at the homologous position (H404) was protonated (pH 6.0).	Histidine	70-79	potassium voltage-gated channel subfamily A member 3	Homo sapiens	55-60
19266161-1	2009	Histidine decarboxylase (HDC) catalyzes the formation of histamine from histidine.	Histidine	72-81	histidine decarboxylase	Homo sapiens	0-23
9407045-0	1997	On the formation and reactivity of compound I of the His-64 myoglobin mutants.	Histidine	53-56	myoglobin	Physeter catodon	60-69
9407045-5	1997	The results unambiguously indicate that His-64 plays a key role in destabilizing wild type Mb-I.	Histidine	40-43	myoglobin	Physeter catodon	91-95
9407092-11	1997	Taken together, these data reveal a second region of interaction with the p75 receptor in NGF with the positively charged residues Lys-74 and His-75 as candidate points of contact.	Histidine	142-145	nerve growth factor receptor	Rattus norvegicus	74-77
19266161-1	2009	Histidine decarboxylase (HDC) catalyzes the formation of histamine from histidine.	Histidine	72-81	histidine decarboxylase	Homo sapiens	25-28
19146426-8	2009	This His/Arg-18 mutation results in reduced affinity binding of human IAPP to insulin in comparison to rat IAPP as it is detected by surface plasmon resonance biosensor analysis.	Histidine	5-8	islet amyloid polypeptide	Homo sapiens	70-74
19028475-4	2009	First, the steroid 5beta-reductase (AKR1D1), which reduces CC double bonds instead of carbonyl groups, has a Glu substituted for His.	Histidine	129-132	aldo-keto reductase family 1 member D1	Homo sapiens	36-42
9398335-3	1997	Sequence comparisons of ACC oxidases with isopenicillin N synthase (IPNS) and members of the 2-oxoglutarate Fe(II) dependent dioxygenases show an aspartate and two of six ACC oxidase conserved histidine residues are completely conserved throughout this subfamily of Fe(II) dependent oxygenases/oxidases.	Histidine	193-202	1-aminocyclopropane-1-carboxylate oxidase	Solanum lycopersicum	24-35
19330843-7	2009	The results showed that (1) His-tag purification was more effective than immunoprecipitation for TTP purification; (2) mutations in TTP increased the yield of His-TTP by both purification procedures; and (3) mutations in TTP increased the binding affinity of mutant proteins for Ni-NTA beads.	Histidine	28-31	ZFP36 ring finger protein	Homo sapiens	132-135
9435528-4	1997	Enzymatic degradation of TRH in vivo produces other bioactive peptides such as cyclo(His-Pro).	Histidine	85-88	thyrotropin releasing hormone	Rattus norvegicus	25-28
19330843-7	2009	The results showed that (1) His-tag purification was more effective than immunoprecipitation for TTP purification; (2) mutations in TTP increased the yield of His-TTP by both purification procedures; and (3) mutations in TTP increased the binding affinity of mutant proteins for Ni-NTA beads.	Histidine	28-31	ZFP36 ring finger protein	Homo sapiens	132-135
19330843-7	2009	The results showed that (1) His-tag purification was more effective than immunoprecipitation for TTP purification; (2) mutations in TTP increased the yield of His-TTP by both purification procedures; and (3) mutations in TTP increased the binding affinity of mutant proteins for Ni-NTA beads.	Histidine	28-31	ZFP36 ring finger protein	Homo sapiens	132-135
9435528-5	1997	Because of the short half-life of TRH and the stability of cyclo(His-Pro) in vivo, we postulated that at least part of the peripheral TRH effects on the exocrine pancreatic secretion may be attributed to cyclo(His-Pro), which has been shown to have other biological activities.	Histidine	65-68	thyrotropin releasing hormone	Rattus norvegicus	134-137
19330843-7	2009	The results showed that (1) His-tag purification was more effective than immunoprecipitation for TTP purification; (2) mutations in TTP increased the yield of His-TTP by both purification procedures; and (3) mutations in TTP increased the binding affinity of mutant proteins for Ni-NTA beads.	Histidine	159-162	ZFP36 ring finger protein	Homo sapiens	132-135
19330843-7	2009	The results showed that (1) His-tag purification was more effective than immunoprecipitation for TTP purification; (2) mutations in TTP increased the yield of His-TTP by both purification procedures; and (3) mutations in TTP increased the binding affinity of mutant proteins for Ni-NTA beads.	Histidine	159-162	ZFP36 ring finger protein	Homo sapiens	132-135
9435528-5	1997	Because of the short half-life of TRH and the stability of cyclo(His-Pro) in vivo, we postulated that at least part of the peripheral TRH effects on the exocrine pancreatic secretion may be attributed to cyclo(His-Pro), which has been shown to have other biological activities.	Histidine	210-213	thyrotropin releasing hormone	Rattus norvegicus	134-137
9435528-7	1997	TRH and its metabolite cyclo(His-Pro) dose dependently inhibited 2-deoxy-D-glucose (2-DG)-stimulated pancreatic secretion.	Histidine	29-32	thyrotropin releasing hormone	Rattus norvegicus	0-3
19330843-7	2009	The results showed that (1) His-tag purification was more effective than immunoprecipitation for TTP purification; (2) mutations in TTP increased the yield of His-TTP by both purification procedures; and (3) mutations in TTP increased the binding affinity of mutant proteins for Ni-NTA beads.	Histidine	159-162	ZFP36 ring finger protein	Homo sapiens	132-135
20716406-1	2009	BACKGROUND: Fragile histidine triad (FHIT) is a candidate tumor suppressor gene.	Histidine	20-29	fragile histidine triad diadenosine triphosphatase	Homo sapiens	37-41
9414234-0	1997	The tautomeric state of histidines in myoglobin.	Histidine	24-34	myoglobin	Physeter catodon	38-47
9414234-3	1997	Of the nine histidines not interacting with the heme in sperm whale myoglobin, it was found that seven (His-12, His-48, His-81, His-82, His-113, His-116, and His-119) are predominantly in the N epsilon2H form with varying degrees of contribution from the Ndelta1 H form.	Histidine	12-22	myoglobin	Physeter catodon	68-77
9414234-10	1997	With the experimentally determined tautomeric state composition in solution, it will be possible to broaden the scope of other studies focused on the electrostatic contribution of histidines to the thermodynamic properties of myoglobin.	Histidine	180-190	myoglobin	Physeter catodon	226-235
15907824-3	2005	Disruptions to gap junctional connexin40 (Cx40) have been reported in distal (i.e., apically located), but not proximal His-Purkinje conduction tissues of the HF-1b knockout mouse.	Histidine	120-123	gap junction protein, alpha 5	Mus musculus	30-40
15907824-3	2005	Disruptions to gap junctional connexin40 (Cx40) have been reported in distal (i.e., apically located), but not proximal His-Purkinje conduction tissues of the HF-1b knockout mouse.	Histidine	120-123	gap junction protein, alpha 5	Mus musculus	42-46
18927217-3	2009	We found that its amino acid sequence (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH(2)) was identical to that of mammalian GnRH.	Histidine	44-47	gonadotropin releasing hormone 1	Homo sapiens	122-126
9382895-2	1997	We have mutated Arg148, which is perfectly conserved in all inward rectifiers, to His in the H5 of IRK1 (<protein-id="3759">Kir2.	Histidine	82-85	potassium inwardly rectifying channel subfamily J member 2	Homo sapiens	99-103
9356458-3	1997	Most HH patients are homozygous for a Cys-282--&gt;Tyr (C282Y) mutation in HFE gene, which has been shown to disrupt interaction with beta2-microglobulin; a second mutation, His-63--&gt;Asp (H63D), is enriched in HH patients who are heterozygous for C282Y mutation.	Histidine	174-177	homeostatic iron regulator	Homo sapiens	75-78
19129393-4	2009	Ammonia and intracellular alkalization activate TRPV1 through a mechanism that involves a cytoplasmic histidine residue, not used by other TRPV1 agonists such as heat, capsaicin or low pH.	Histidine	102-111	transient receptor potential cation channel subfamily V member 1	Homo sapiens	48-53
9390441-9	1997	Overall, LHT1 belongs to a new class of amino acid transporter that is specific for Lys and histidine, and, given its substrate specificity, it has significant promise as a tool for improving the Lys content of Lys-deficient grains.	Histidine	92-101	lysine histidine transporter 1	Arabidopsis thaliana	9-13
16115913-2	2005	The fragile histidine triad (FHIT) gene is a tumor suppressor gene that is altered in 80% of tobacco-associated lung cancers.	Histidine	12-21	fragile histidine triad diadenosine triphosphatase	Homo sapiens	29-33
15951442-0	2005	Key role of conserved histidines in recombinant mouse beta-carotene 15,15"-monooxygenase-1 activity.	Histidine	22-32	beta-carotene oxygenase 1	Mus musculus	54-90
15951442-1	2005	Alignment of sequences of vertebrate beta-carotene 15,15"-monooxygenase-1 (BCMO1) and related oxygenases revealed four perfectly conserved histidines and five acidic residues (His172, His237, His308, His514, Asp52, Glu140, Glu314, Glu405, and Glu457 in mouse BCMO1).	Histidine	139-149	beta-carotene oxygenase 1	Mus musculus	37-73
15951442-1	2005	Alignment of sequences of vertebrate beta-carotene 15,15"-monooxygenase-1 (BCMO1) and related oxygenases revealed four perfectly conserved histidines and five acidic residues (His172, His237, His308, His514, Asp52, Glu140, Glu314, Glu405, and Glu457 in mouse BCMO1).	Histidine	139-149	beta-carotene oxygenase 1	Mus musculus	75-80
15951442-3	2005	To test this hypothesis, we produced mutant forms of mouse BCMO1 by replacing the conserved histidines and acidic residues as well as four histidines and one glutamate non-conserved in the overall family with alanines by site-directed mutagenesis.	Histidine	92-102	beta-carotene oxygenase 1	Mus musculus	59-64
16055450-1	2005	Six Cys(2)His(2) zinc fingers (F1-6) comprise the DNA binding domain of metal-responsive element binding transcription factor-1 (MTF-1).	Histidine	10-13	metal regulatory transcription factor 1	Homo sapiens	129-134
18991392-8	2008	The pH dependence of V(max) for both glutamate variants yields pK(a) values of 6.0 and 8.7, compared to those in the wild-type enzyme of 6.4 and 9.3, respectively, indicating that the basicity of His-464" in TrxR in complex with its substrate, DmTrx-2, is significantly lower in the glutamate variants than in wild-type enzyme.	Histidine	196-199	thioredoxin-2	Drosophila melanogaster	244-251
18717684-2	2008	However, a significant fraction of periocular sebaceous gland carcinomas exhibits microsatellite stability associated with a frequent loss of the candidate tumour suppressor fragile histidine triad (FHIT).	Histidine	182-191	fragile histidine triad diadenosine triphosphatase	Homo sapiens	199-203
9367166-0	1997	Effect of chemical glycosylation of RNase A on the protein stability and surface histidines accessibility in immobilized metal ion affinity electrophoresis (IMAGE) system.	Histidine	81-91	ribonuclease A family member 1, pancreatic	Homo sapiens	36-43
18797193-5	2008	We identified a permissive region in the pore-loop of repeat IV within the Ca(V)2.1 alpha(1) subunit, which allowed integration of several different tags (hemagluttinine [HA], double HA; 6-histidine tag [His], 9-His, bungarotoxin-binding site) without compromising alpha(1) subunit protein expression (in transfected tsA-201 cells) and function (after expression in X. laevis oocytes).	Histidine	204-207	immunoglobulin lambda variable 3-1	Homo sapiens	75-83
9367166-1	1997	Immobilized metal ion affinity gel electrophoresis (IMAGE) has been applied to study the change of the surface histidines topography of RNase A when chemically glycosylated on exposed carboxylic groups with glucosamine using carbodiimide as cross-linker, under mild conditions.	Histidine	111-121	ribonuclease A family member 1, pancreatic	Homo sapiens	136-143
15803144-6	2005	After screening several histidine-lysine polymers in complex with Raf-1 siRNA to reduce tumor growth, we further evaluated the efficacy of this siRNA in complex with the optimal histidine-lysine carrier to reduce the tumor growth in vivo.	Histidine	24-33	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	66-71
18797193-5	2008	We identified a permissive region in the pore-loop of repeat IV within the Ca(V)2.1 alpha(1) subunit, which allowed integration of several different tags (hemagluttinine [HA], double HA; 6-histidine tag [His], 9-His, bungarotoxin-binding site) without compromising alpha(1) subunit protein expression (in transfected tsA-201 cells) and function (after expression in X. laevis oocytes).	Histidine	212-215	immunoglobulin lambda variable 3-1	Homo sapiens	75-83
9466326-5	1997	Based upon binding and activity data obtained from ten different GLP-1 analogues we show that not the positive charge of the free alpha-amino group but the positive charge of the imidazole side chain of histidine is crucial for GLP-1 action.	Histidine	203-212	glucagon like peptide 1 receptor	Homo sapiens	65-70
18486465-2	2008	The recombinant histidine-tagged silk proteinase inhibitor protein (rSPI2-His(6)) expressed in Pichia system selected as antigen for this immonosensor.	Histidine	16-25	serine (or cysteine) proteinase inhibitor, clade A, member 3C	Rattus norvegicus	68-73
9466326-5	1997	Based upon binding and activity data obtained from ten different GLP-1 analogues we show that not the positive charge of the free alpha-amino group but the positive charge of the imidazole side chain of histidine is crucial for GLP-1 action.	Histidine	203-212	glucagon like peptide 1 receptor	Homo sapiens	228-233
9332345-0	1997	Paralogous histidine biosynthetic genes: evolutionary analysis of the Saccharomyces cerevisiae HIS6 and HIS7 genes.	Histidine	11-20	1-(5-phosphoribosyl)-5- ((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase HIS6	Saccharomyces cerevisiae S288C	95-99
15902282-1	2005	To clarify the role of fragile histidine triad (FHIT) in hematological malignancies, we examined the methylation status and the expression level of the FHIT gene in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) cells in comparison with the methylation of the p15(INK4B) gene.	Histidine	31-40	fragile histidine triad diadenosine triphosphatase	Homo sapiens	48-52
16255988-10	2005	Caspase-2 protein expression was positive in 8 of the 10 (80%) of the control rats with an HIS of 5.92 +/- 0.9.	Histidine	91-94	caspase 2	Rattus norvegicus	0-9
9332345-0	1997	Paralogous histidine biosynthetic genes: evolutionary analysis of the Saccharomyces cerevisiae HIS6 and HIS7 genes.	Histidine	11-20	imidazoleglycerol-phosphate synthase	Saccharomyces cerevisiae S288C	104-108
18694848-4	2008	Both SMS1 and SMS2 contain two histidines and one aspartic acid which are evolutionary conserved within the lipid phosphate phosphatase superfamily.	Histidine	31-41	sphingomyelin synthase 2	Homo sapiens	14-18
9349705-1	1997	The HIS7 gene of Saccharomyces cerevisiae encodes a bifunctional glutamine amidotransferase: cyclase that catalyzes the formation of biosynthetic precursors for histidine and adenine.	Histidine	161-170	imidazoleglycerol-phosphate synthase	Saccharomyces cerevisiae S288C	4-8
18794864-3	2008	Using an interactive computational-experimental approach, we show that sodium sensitivity of Kir channels involves the side chains of an aspartate and a histidine located across from each other in a crucial loop in the cytosolic domain, as well as the backbone carbonyls of two more residues and a water molecule.	Histidine	153-162	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	93-96
9256424-3	1997	Here we report that nm23-H1 can transfer a phosphate from its catalytic histidine to aspartate or glutamate residues on 43-kDa membrane proteins.	Histidine	72-81	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	20-27
9256424-5	1997	Nm23-H1 also can transfer phosphate from its catalytic histidine to histidines on ATP-citrate lyase and succinic thiokinase.	Histidine	55-64	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	0-7
9256424-5	1997	Nm23-H1 also can transfer phosphate from its catalytic histidine to histidines on ATP-citrate lyase and succinic thiokinase.	Histidine	68-78	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	0-7
9273895-6	1997	Peptides Boc-His-Pro-Phe-His-Ads-Val-Ile-His-NH2 (VII) having Ads at position 10 had an IC50 of 12 nM against rat renin.	Histidine	13-16	renin	Rattus norvegicus	114-119
9273895-6	1997	Peptides Boc-His-Pro-Phe-His-Ads-Val-Ile-His-NH2 (VII) having Ads at position 10 had an IC50 of 12 nM against rat renin.	Histidine	25-28	renin	Rattus norvegicus	114-119
9273895-6	1997	Peptides Boc-His-Pro-Phe-His-Ads-Val-Ile-His-NH2 (VII) having Ads at position 10 had an IC50 of 12 nM against rat renin.	Histidine	25-28	renin	Rattus norvegicus	114-119
15963506-2	2005	To purify and study the function of the ATPase, the enzyme was truncated by five of the six metal binding domains and endowed with an N-terminal histidine-tag for affinity purification.	Histidine	145-154	dynein axonemal heavy chain 8	Homo sapiens	40-46
15849248-4	2005	In wild-type deoxy myoglobin, the passage between the distal pocket and the solvent is strictly correlated to the presence/absence of a water molecule that simultaneously interacts with the distal histidine side chain and the heme iron; conversely, in the photodissociated myoglobin, the connection with the bulk solvent is always open when CO is in the vicinity of the A pyrrole ring.	Histidine	197-206	myoglobin	Physeter catodon	19-28
18796614-3	2008	We now show that the mammalian protein histidine phosphatase (PHPT-1) directly binds and inhibits KCa3.1 by dephosphorylating histidine 358 on KCa3.1.	Histidine	39-48	potassium calcium-activated channel subfamily N member 4	Homo sapiens	98-104
18796614-3	2008	We now show that the mammalian protein histidine phosphatase (PHPT-1) directly binds and inhibits KCa3.1 by dephosphorylating histidine 358 on KCa3.1.	Histidine	39-48	potassium calcium-activated channel subfamily N member 4	Homo sapiens	143-149
18756395-3	2008	In most histamine-containing foods the majority of the histamine is generated by decarboxylation of the histidine through histidine decarboxylase enzymes derived from the bacteria present in food.	Histidine	104-113	histidine decarboxylase	Homo sapiens	122-145
16030101-1	2005	OBJECTIVE: The fragile histidine triad (FHIT) gene is a putative tumor suppressor gene that is thought to be involved in the carcinogenesis of breast cancer.	Histidine	23-32	fragile histidine triad diadenosine triphosphatase	Homo sapiens	40-44
9261067-1	1997	BACKGROUND: The fragile histidine triad (FHIT) protein is a member of the large and ubiquitous histidine triad (HIT) family of proteins.	Histidine	24-33	fragile histidine triad diadenosine triphosphatase	Homo sapiens	41-45
9261067-1	1997	BACKGROUND: The fragile histidine triad (FHIT) protein is a member of the large and ubiquitous histidine triad (HIT) family of proteins.	Histidine	95-104	fragile histidine triad diadenosine triphosphatase	Homo sapiens	41-45
18450746-5	2008	In the present study we demonstrate that His-119/His-120 and Cys-409 are the axial ligands for the Fe(III)-protoporphyrin IX complex (hemin) in HRI, based on spectral data on site-directed mutant proteins.	Histidine	41-44	eukaryotic translation initiation factor 2 alpha kinase 1	Homo sapiens	144-147
9166854-7	1997	In a Northern blot analysis from homogeneous tissue biopsy from the intradermal injection sites, RANTES was more potent than MCP-1 in increasing histidine decarboxylase (HDC) mRNA, the sole enzyme responsible for the production of histamine from histidine.	Histidine	145-154	histidine decarboxylase	Rattus norvegicus	170-173
16029163-0	2005	Expression, refolding and characterization of human brain serine racemase in Escherichia coli with N-terminal His-tag.	Histidine	110-113	serine racemase	Homo sapiens	58-73
16029163-1	2005	Human brain serine racemase (hSR) was expressed in large amounts in E. coli with N-terminal His-tag (His-hSR).	Histidine	92-95	serine racemase	Homo sapiens	12-27
16029163-1	2005	Human brain serine racemase (hSR) was expressed in large amounts in E. coli with N-terminal His-tag (His-hSR).	Histidine	101-104	serine racemase	Homo sapiens	12-27
18450746-5	2008	In the present study we demonstrate that His-119/His-120 and Cys-409 are the axial ligands for the Fe(III)-protoporphyrin IX complex (hemin) in HRI, based on spectral data on site-directed mutant proteins.	Histidine	49-52	eukaryotic translation initiation factor 2 alpha kinase 1	Homo sapiens	144-147
18467526-7	2008	The different residues in GnRH II (His(5), Trp(7), Tyr(8)) were introduced singly or in pairs into GnRH I. Tyr(5) replacement by His(5) produced the highest increase in the antiproliferative potency of GnRH I. Tyr(8) substitution of Arg(8) produced the most selective analog, with very poor inositol phosphate generation but high antiproliferative potency.	Histidine	35-38	gonadotropin releasing hormone 2	Homo sapiens	26-33
16078573-1	2005	OBJECTIVE: To explore the relationship of loss of heterozygosity (LOH) and microsatellite instability (MI) of fragile histidine triad (FHIT) gene to the development of cervical carcinoma.	Histidine	118-127	fragile histidine triad diadenosine triphosphatase	Homo sapiens	135-139
18395846-7	2008	The His(5)-Phe(23)-PTHrP-1-36 caused an increase in the K(D) from 2.0 +/- 0.03 nM to 2.75 +/- 0.045 nM in MCF7 cells, but had no significant effect in SaOS-2 cells.	Histidine	4-7	parathyroid hormone like hormone	Homo sapiens	19-24
15899373-3	2005	The DUE-B protein was expressed with an added C-terminal sequence of six adjacent histidine residues, a His6-tag and immobilized on a chiral ligand exchange support, the CLC-L column, using Ni2+ as the coordinating metal ion.	Histidine	82-91	D-aminoacyl-tRNA deacylase 1	Homo sapiens	4-9
19471558-1	2008	OBJECTIVE: The abnormal expression of fragile histidine triad (FHIT) gene has been frequently reported in a variety of epithelial malignancies including cervical carcinoma.	Histidine	46-55	fragile histidine triad diadenosine triphosphatase	Homo sapiens	63-67
15906398-2	2005	For example, histidine and phenylalanine ammonia-lyases (HAL and PAL) trigger the abstraction of the nonacidic beta protons of these amino acids while leaving the much more acidic ammonium hydrogen atoms untouched.	Histidine	13-22	SHC binding and spindle associated 1	Homo sapiens	65-68
15870890-7	2005	Rat Nlk gene encoded 515-aa Nlk protein with the serine/threonine kinase domain, poly(His) tracts and poly(Ala) tract, which showed 100, 99.8, 97.1 and 89.5% total-amino-acid identity with mouse Nlk, human NLK, Xenopus nlk and zebrafish nlk, respectively.	Histidine	86-89	nemo like kinase	Rattus norvegicus	4-7
18596417-7	2008	Here, we summarize these findings with special emphasis on the histidine triad proteins Hint1 and Fhit and their repressive activity on the beta-catenin signaling function.	Histidine	63-72	fragile histidine triad diadenosine triphosphatase	Homo sapiens	98-102
18221322-1	2008	BACKGROUND: The purpose of this study was to determine fragile histidine triad (FHIT) and p53 protein expression, and to analyze FHIT and p53 gene status in keratocystic odontogenic tumor (KOT), dentigerous cysts (DC) and radicular cysts (RC).	Histidine	63-72	fragile histidine triad diadenosine triphosphatase	Homo sapiens	80-84
15870890-7	2005	Rat Nlk gene encoded 515-aa Nlk protein with the serine/threonine kinase domain, poly(His) tracts and poly(Ala) tract, which showed 100, 99.8, 97.1 and 89.5% total-amino-acid identity with mouse Nlk, human NLK, Xenopus nlk and zebrafish nlk, respectively.	Histidine	86-89	nemo like kinase	Rattus norvegicus	28-31
15870890-7	2005	Rat Nlk gene encoded 515-aa Nlk protein with the serine/threonine kinase domain, poly(His) tracts and poly(Ala) tract, which showed 100, 99.8, 97.1 and 89.5% total-amino-acid identity with mouse Nlk, human NLK, Xenopus nlk and zebrafish nlk, respectively.	Histidine	86-89	nemo like kinase	Mus musculus	28-31
15788390-7	2005	The active site histidines, His-10 of IIA(Man) and His-15 (italics indicate HPr residues) of HPr, are in close proximity.	Histidine	16-26	haptoglobin-related protein	Homo sapiens	76-79
21479430-3	2008	We investigated whether this 10-residue histidine tract polymorphism of the ZIC2 gene (c.718_720dupCAC) was associated with the risk of NTDs in a sample of 138 patients and their parents from the Latin American Collaborative Study of Congenital Malformations (ECLAMC) hospital network.	Histidine	40-49	Zic family member 2	Homo sapiens	76-80
15788390-7	2005	The active site histidines, His-10 of IIA(Man) and His-15 (italics indicate HPr residues) of HPr, are in close proximity.	Histidine	16-26	haptoglobin-related protein	Homo sapiens	93-96
15788390-7	2005	The active site histidines, His-10 of IIA(Man) and His-15 (italics indicate HPr residues) of HPr, are in close proximity.	Histidine	28-31	haptoglobin-related protein	Homo sapiens	76-79
18227067-4	2008	Mutation of the S4 arginine closest to the cytosolic side of KCa3.1 to histidine resulted in expression at the cell surface.	Histidine	71-80	potassium calcium-activated channel subfamily N member 4	Homo sapiens	61-67
15858043-2	2005	Among these residues, aspartate 92 and histidine 117 are both required for Fv1(b) resistance, whereas the latter is sufficient to confer Ref1 resistance.	Histidine	39-48	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	137-141
18275840-1	2008	The influence of the histidine axial ligand to the PD1 chlorophyll of photosystem II on the redox potential and spectroscopic properties of the primary electron donor, P680, was investigated in mutant oxygen-evolving photosystem II (PSII) complexes purified from the thermophilic cyanobacterium Thermosynechococcus elongatus.	Histidine	21-30	programmed cell death 1	Homo sapiens	51-54
15741341-8	2005	This pH-sensitive aggregation behavior is explained by a dense cluster of positively charged residues at the SDF1 dimer interface that includes a histidine side chain at its center.	Histidine	146-155	C-X-C motif chemokine ligand 12	Homo sapiens	109-113
18297188-5	2008	We have expressed IRP1 using the plasmid pT7-His-hIRP1, which codifies for human IRP1 attached to an NH2-terminal 6-His tag.	Histidine	45-48	aconitase 1	Homo sapiens	18-22
15837191-5	2005	These two domains, as well as the structurally unrelated ubiquitin binding motif UIM, provide a common, crucial recognition site for ubiquitin, comprising a hydrogen-bonding acceptor for the amide group of Gly-47, and a methyl group that packs against the hydrophobic pocket of ubiquitin formed by Leu-8, Ile-44, His-68, and Val-70.	Histidine	313-316	ubiquitin	Saccharomyces cerevisiae S288C	57-66
18297188-5	2008	We have expressed IRP1 using the plasmid pT7-His-hIRP1, which codifies for human IRP1 attached to an NH2-terminal 6-His tag.	Histidine	45-48	aconitase 1	Homo sapiens	49-54
15837191-5	2005	These two domains, as well as the structurally unrelated ubiquitin binding motif UIM, provide a common, crucial recognition site for ubiquitin, comprising a hydrogen-bonding acceptor for the amide group of Gly-47, and a methyl group that packs against the hydrophobic pocket of ubiquitin formed by Leu-8, Ile-44, His-68, and Val-70.	Histidine	313-316	ubiquitin	Saccharomyces cerevisiae S288C	133-142
15837191-5	2005	These two domains, as well as the structurally unrelated ubiquitin binding motif UIM, provide a common, crucial recognition site for ubiquitin, comprising a hydrogen-bonding acceptor for the amide group of Gly-47, and a methyl group that packs against the hydrophobic pocket of ubiquitin formed by Leu-8, Ile-44, His-68, and Val-70.	Histidine	313-316	ubiquitin	Saccharomyces cerevisiae S288C	133-142
18297188-5	2008	We have expressed IRP1 using the plasmid pT7-His-hIRP1, which codifies for human IRP1 attached to an NH2-terminal 6-His tag.	Histidine	45-48	aconitase 1	Homo sapiens	50-54
18021260-5	2008	Replacement of a single residue (His--&gt;Ala) in the catalytic center reduced the activity of HDACs 1 and 2 by 80%, and abolished HDAC3 activity; the mutant HDACs were expressed at similar levels and in the same multiprotein complexes as wild-type HDACs.	Histidine	33-36	histone deacetylase 3	Homo sapiens	131-136
15713463-11	2005	Since the overall structure of hCNP-CF differs considerably from that of RNase A, it is likely that the similar active sites with two catalytic histidine residues in these enzymes arose through convergent evolution.	Histidine	144-153	ribonuclease A family member 1, pancreatic	Homo sapiens	73-80
15574419-1	2005	To compare kinetic properties of homologous isozymes of NADP+-specific isocitrate dehydrogenase, histidine-tagged forms of yeast mitochondrial (IDP1) and cytosolic (IDP2) enzymes were expressed and purified.	Histidine	97-106	isocitrate dehydrogenase (NADP(+)) IDP2	Saccharomyces cerevisiae S288C	165-169
15650878-7	2005	Indeed, the mutation spectrums of purified His-hAID and GST-hAID matched the trinucleotide mutability indexes in Ramos cells and in msh2(-/-)ung(-/-) mice.	Histidine	43-46	mutS homolog 2	Homo sapiens	132-136
15567179-1	2005	The three human SEC14-like proteins TAP1, TAP2, and TAP3 were expressed in Escherichia coli and purified by means of an amino-terminal His-tag.	Histidine	135-138	SEC14 like lipid binding 4	Homo sapiens	52-56
18272581-4	2008	In vitro kinase assays using full-length His-IRF-3 as a substrate combined with mass spectrometry analysis revealed that serine 402 and serine 396 are directly targeted by TBK1.	Histidine	41-44	interferon regulatory factor 3	Mus musculus	45-50
15567419-1	2005	pH-Dependent studies of the folding kinetics and stability of a set of His to Gln point mutants were used to characterize the denatured state and transition state ensembles for the C-terminal domain of the ribosomal protein L9 (CTL9).	Histidine	71-74	ribosomal protein L9	Homo sapiens	206-226
18272581-4	2008	In vitro kinase assays using full-length His-IRF-3 as a substrate combined with mass spectrometry analysis revealed that serine 402 and serine 396 are directly targeted by TBK1.	Histidine	41-44	TANK-binding kinase 1	Mus musculus	172-176
18243046-5	2008	Furthermore, the status of the fragile histidine triad gene (FHIT) in chromosome band 3p14.2 was studied by fluorescence in situ hybridization (FISH) in epithelial cells that had been cultured after removal of bleomycin.	Histidine	39-48	fragile histidine triad diadenosine triphosphatase	Homo sapiens	61-65
15610452-1	2005	BACKGROUND AND AIM: The present study was conducted to address whether homozygous deletion (HZD) or transcriptional alterations of the fragile histidine triad (FHIT) gene play a role in the development and progression of hepatitis C virus-associated hepatocellular carcinoma (HCC).	Histidine	143-152	fragile histidine triad diadenosine triphosphatase	Homo sapiens	160-164
17965005-3	2008	PCC6803 in which the axial ligand, D1-His198, of special pair chlorophyll PD1 was replaced with Gln and where D1-Thr179, which overlies monomeric chlorophyll ChlD1, was replaced with His.	Histidine	38-41	programmed cell death 1	Homo sapiens	74-77
18226913-5	2008	The mode of inhibition has also been confirmed by (1)H NMR studies of the active site histidines of RNase A.	Histidine	86-96	ribonuclease A family member 1, pancreatic	Homo sapiens	100-107
15344908-9	2004	A unique zinc-finger motif composed of two contiguous Cys(2)His(2)-type fingers is common to both forms of ZFF29.	Histidine	60-63	zinc finger protein 367	Homo sapiens	107-112
18202004-3	2008	CCM1 has two putative zinc-binding domains with several conserved cysteine and histidine residues in its N-terminal region.	Histidine	79-88	uncharacterized protein	Chlamydomonas reinhardtii	0-4
15548613-3	2004	Unlike in Mb, in Ngb the sixth coordination position of the heme iron is occupied by the distal histidine, in the absence of an exogenous ligand.	Histidine	96-105	neuroglobin	Mus musculus	17-20
18247301-1	2008	OBJECTIVE: To study the methylation status of fragile histidine triad (FHIT) gene promoter in patients with myelodysplastic syndrome (MDS) and its clinical relevance.	Histidine	54-63	fragile histidine triad diadenosine triphosphatase	Homo sapiens	71-75
15480422-4	2004	All of the deleted regions were located within the fragile histidine triad (FHIT) gene, and the most frequent region of loss was mapped to 0.4 Mbp of the region encompassing the introns 4 and 5 and exon 5 of the FHIT gene.	Histidine	59-68	fragile histidine triad diadenosine triphosphatase	Homo sapiens	76-80
18235846-10	2008	Comparative modeling of the three-dimensional structure of E. histolytica putative ODC shows that the putative binding site for DFMO is disrupted by the substitution of three amino acids-aspartate-332, aspartate-361, and tyrosine-323-by histidine-296, phenylalanine-305, and asparagine-334, through which this inhibitor interacts with the protein.	Histidine	237-246	ornithine decarboxylase 1	Homo sapiens	83-86
15489891-1	2004	The expression of the tumour suppressor protein fragile histidine triad (Fhit) is often impaired in many human cancers and its restoration in Fhit-negative cancer cell lines suppresses tumorigenicity and induces apoptosis.	Histidine	56-65	fragile histidine triad diadenosine triphosphatase	Homo sapiens	73-77
15489891-1	2004	The expression of the tumour suppressor protein fragile histidine triad (Fhit) is often impaired in many human cancers and its restoration in Fhit-negative cancer cell lines suppresses tumorigenicity and induces apoptosis.	Histidine	56-65	fragile histidine triad diadenosine triphosphatase	Homo sapiens	142-146
9157994-2	1997	Recently, the FHIT (fragile histidine triad) gene was identified at 3p14.2 as a candidate tumor suppressor gene.	Histidine	28-37	fragile histidine triad diadenosine triphosphatase	Homo sapiens	14-18
18618300-0	2008	Inverse correlation of aberrant expression of fragile histidine triad (FHIT) protein with cyclin D1 protein and prognosis in Chinese patients with cholangiocarcinoma.	Histidine	54-63	fragile histidine triad diadenosine triphosphatase	Homo sapiens	71-75
9169852-3	1997	Sequencing of the three pag-3 alleles showed that two apparent null alleles encode a nonsense mutation before the zinc fingers and a missense mutation in the fourth zinc finger that changes a coordinating histidine to a tyrosine.	Histidine	205-214	Uncharacterized protein	Caenorhabditis elegans	24-29
15384174-0	2004	Frequent silencing of fragile histidine triad gene (FHIT) in Burkitt"s lymphoma is associated with aberrant hypermethylation.	Histidine	30-39	fragile histidine triad diadenosine triphosphatase	Homo sapiens	52-56
15384174-1	2004	The fragile histidine triad (FHIT) gene, a potential tumor-suppressor gene, is frequently inactivated in multiple human cancers.	Histidine	12-21	fragile histidine triad diadenosine triphosphatase	Homo sapiens	29-33
18618300-0	2008	Inverse correlation of aberrant expression of fragile histidine triad (FHIT) protein with cyclin D1 protein and prognosis in Chinese patients with cholangiocarcinoma.	Histidine	54-63	cyclin D1	Homo sapiens	90-99
18037383-1	2007	We recently reported that a histidine (H191) in the S3-S4 loop of domain I is critical for nickel inhibition of the Cav3.2 T-type Ca2+ channel.	Histidine	28-37	calcium voltage-gated channel subunit alpha1 H	Homo sapiens	116-122
15375167-5	2004	In silico modeling followed by mutagenesis and the in vitro and cell-based binding studies showed that the His(171)-Glu-Lys-Gln-Ala-Asp(176) and Val(223)-Arg-Asn(224) peptide sequences of MT1-MMP are directly involved in the binding with C1q.	Histidine	107-110	matrix metallopeptidase 14	Homo sapiens	188-195
9114073-5	1997	Mutational analysis allowed us to relate this acid activation to both extracellular histidines in KST1.	Histidine	84-94	solute carrier family 5 member 11	Homo sapiens	98-102
9114073-8	1997	Among the single mutants, replacement of the pore histidine, which is highly conserved in plant K+ channels, increased or even inverted the pH sensitivity of KST1.	Histidine	50-59	solute carrier family 5 member 11	Homo sapiens	158-162
18037383-2	2007	As in Cav3.2, two histidine residues are commonly found in the IS3-IS4 loops of mammalian Cav2.3 Ca2+ channels, which are also blocked by low micromolar concentrations of nickel.	Histidine	18-27	calcium voltage-gated channel subunit alpha1 H	Homo sapiens	6-12
9137418-9	1997	The hMSH2 human mismatch repair protein linked to the hereditary nonpolyposis colon cancer gene, has a weak nuclear signal containing two histidines.	Histidine	138-148	mutS homolog 2	Homo sapiens	4-9
15355958-3	2004	It was recently reported, however, that when Myc-MAP1LC3B-His is expressed in HEK293 cells, its carboxyl terminus is not cleaved.	Histidine	58-61	microtubule associated protein 1 light chain 3 beta	Homo sapiens	49-57
15355958-8	2004	When MAP1LC3B-3xFLAG and Myc-MAP1LC3B-His were expressed in HEK293 cells, their carboxyl termini were cleaved, whereas there was little cleavage of mutant proteins MAP1LC3B(G120A)-3xFLAG and Myc-MAP1LC3B(G120A)-His, containing Ala in place of Gly(120).	Histidine	38-41	microtubule associated protein 1 light chain 3 beta	Homo sapiens	29-37
15355958-8	2004	When MAP1LC3B-3xFLAG and Myc-MAP1LC3B-His were expressed in HEK293 cells, their carboxyl termini were cleaved, whereas there was little cleavage of mutant proteins MAP1LC3B(G120A)-3xFLAG and Myc-MAP1LC3B(G120A)-His, containing Ala in place of Gly(120).	Histidine	38-41	microtubule associated protein 1 light chain 3 beta	Homo sapiens	29-37
17359554-6	2007	In nasopharyngeal carcinoma, loss of heterozygosity at the FRA3B/fragile histidine triad locus correlated with the following clinicopathological parameters: tumour T-stage, lymph node status, clinical stage, tumour differentiation and serum antibody titres of immunoglobulin (Ig) A against Epstein-Barr virus capsid antigen.	Histidine	73-82	fragile histidine triad diadenosine triphosphatase	Homo sapiens	59-64
15355958-8	2004	When MAP1LC3B-3xFLAG and Myc-MAP1LC3B-His were expressed in HEK293 cells, their carboxyl termini were cleaved, whereas there was little cleavage of mutant proteins MAP1LC3B(G120A)-3xFLAG and Myc-MAP1LC3B(G120A)-His, containing Ala in place of Gly(120).	Histidine	38-41	microtubule associated protein 1 light chain 3 beta	Homo sapiens	29-37
9119391-10	1997	The two polymorphic GPT isozymes are the results of a nucleotide substitution in codon 14, coding for a histidine in GPT-1 and an asparagine in GPT-2, which causes a gain or loss of an NlaIII restriction site.	Histidine	104-113	glutamic--pyruvic transaminase	Homo sapiens	20-23
9119391-10	1997	The two polymorphic GPT isozymes are the results of a nucleotide substitution in codon 14, coding for a histidine in GPT-1 and an asparagine in GPT-2, which causes a gain or loss of an NlaIII restriction site.	Histidine	104-113	glutamic--pyruvic transaminase	Homo sapiens	117-122
17141918-4	2007	The deduced amino acid sequences of the FAD2-3 displayed the typical three histidine boxes characteristic of all membrane-bound desaturases, and possessed a C-terminal signal for ER retention.	Histidine	75-84	omega-6 fatty acid desaturase	Glycine max	40-44
20836168-8	2007	Histidine, methionine and tyrosine are the amino acids most likely to be responsible for the strong antioxidant activity of phosvitin peptides.	Histidine	0-9	casein kinase 2 beta	Homo sapiens	124-133
9058595-0	1997	Arginine 52 and histidine 54 located in a conserved amino-terminal hydrophobic region (LX2-R52-G-H54-X3-V-L) are important amino acids for the functional and structural integrity of the human liver UDP-glucuronosyltransferase UGT1*6.	Histidine	16-25	UDP glucuronosyltransferase family 1 member A6	Homo sapiens	226-232
9164465-1	1997	Histidine triad nucleotide-binding protein (HINT), a dimeric purine nucleotide-binding protein from rabbit heart, is a member of the HIT (histidine triad) superfamily which includes HINT homologues and FHIT (HIT protein encoded at the chromosome 3 fragile site) homologues.	Histidine	138-147	bis(5'-adenosyl)-triphosphatase	Oryctolagus cuniculus	202-206
15520806-4	2004	Erf2 and Akr1 are integral membrane proteins that contain a cysteine-rich domain and an Asp-His-His-Cys motif, both of which catalyse acylation at the carboxyl terminus of their target proteins.	Histidine	92-95	palmitoyltransferase AKR1	Saccharomyces cerevisiae S288C	9-13
15604023-1	2004	A guanine to adenine point mutation results in an arginine (R) to histidine (H) substitution in FcgammaRIIa at residue 131 that strongly impacts receptor function.	Histidine	66-75	Fc gamma receptor IIa	Homo sapiens	96-107
17918862-1	2007	Previous structural studies of the histidine-containing phosphocarrier protein (HPr) have shown that active site residue His15 can adopt two distinct conformations which were termed OPEN and CLOSED.	Histidine	35-44	haptoglobin-related protein	Homo sapiens	80-83
16028355-5	2004	The model also suggested that the structural preference of BPHL for hydrophobic amino acyl promoieties and its limited activity for the secondary alcohol substrates may be attributed to the hydrophobic acyl-binding site formed by residues I158, G161, I162, and L229, and the spatial constraint around the catalytic site by a loop on one side, the active serine and histidine on the other side, and L53 and L179 on top.	Histidine	365-374	biphenyl hydrolase like	Homo sapiens	59-63
15453723-0	2004	Rational design of an L-histidine-derived minimal artificial acylase for the kinetic resolution of racemic alcohols.	Histidine	22-33	aminoacylase 1	Homo sapiens	61-68
15453723-1	2004	This communication describes the rational design of an l-histidine-derived minimal artificial acylase.	Histidine	55-66	aminoacylase 1	Homo sapiens	94-101
9063454-6	1997	Analysis of the full-length protein was possible with GCNF polypeptides that contain epitopes of six consecutive histidines.	Histidine	113-123	nuclear receptor subfamily 6, group A, member 1	Mus musculus	54-58
17526652-5	2007	This interaction involves the histidine- and glutamic acid-rich domain of HRC (320-460 aa) and the part of the NH(2)-terminal cation transporter domain of SERCA2 (74-90 aa) that projects into the SR lumen.	Histidine	30-39	histidine rich calcium binding protein	Homo sapiens	74-77
9000709-2	1997	We typed 285 IDDM patients and 337 HLA-DRB1-DQA1-DQB1 genotypically matched control subjects from an ethnically homogeneous population for both the G/T polymorphism in intron 6 of the LMP7 gene and the Arg-His polymorphism in the LMP2 gene.	Histidine	206-209	proteasome 20S subunit beta 8	Homo sapiens	184-188
15453723-2	2004	Our new artificial acylase, tert-butyldiphenylsilyl ether of N-(2,4,6-triisopropylbenzenesulfonyl)-pi(Me)-l-histidinol, is a simple and small molecule (molecular weight = 660) that contains only one chiral carbon center that originates from natural l-histidine.	Histidine	249-260	aminoacylase 1	Homo sapiens	19-26
17526652-5	2007	This interaction involves the histidine- and glutamic acid-rich domain of HRC (320-460 aa) and the part of the NH(2)-terminal cation transporter domain of SERCA2 (74-90 aa) that projects into the SR lumen.	Histidine	30-39	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	Homo sapiens	155-161
15319871-2	2004	Previous studies have shown that individuals with the IgG1/3-binding Fc gamma RIIa-Arg/Arg131 genotype are relatively protected against high-density malaria, whereas individuals with the IgG2-binding Fc gamma RIIa-His/His131 genotype are at increased risk for developing cerebral malaria.	Histidine	214-217	Fc gamma receptor IIa	Homo sapiens	200-213
9041652-5	1997	Structure-function analysis of the human glucose-6-phosphatase has shown that two of the conserved residues (the first domain arginine and the central domain histidine) are essential for enzyme activity.	Histidine	158-167	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	41-62
17660358-2	2007	Through expression of profluorescent, photoinsensitive Tyr-to-His mutant alleles of Arabidopsis thaliana phytochrome B (PHYB(Y276H)) and Arabidopsis phytochrome A (PHYA(Y242H)) in transgenic Arabidopsis plants, we demonstrate that photoconversion is not a prerequisite for phytochrome signaling.	Histidine	62-65	phytochrome B	Arabidopsis thaliana	120-124
9116497-6	1997	The histidine-tagged SRP19 bound specifically to a 150-nucleotide RNA derived from SRP RNA, with an apparent Kd of 1 nM, and bound, with greatly reduced affinity, to a mutagenized form of the SRP RNA derivative that contained an altered helix 6 tetranucleotide loop.	Histidine	4-13	signal recognition particle 19	Homo sapiens	21-26
15363189-2	2004	Fragile histidine triad (FHIT) gene is located in 3p14.2, and its deletion or abnormal expression was found in many kinds of cancers.	Histidine	8-17	fragile histidine triad diadenosine triphosphatase	Homo sapiens	25-29
17428396-9	2007	The polyclonal anti-His-RPS13 antibody was obtained by immunizing the mice with RPS13 protein.	Histidine	20-23	ribosomal protein S13	Mus musculus	24-29
15341994-1	2004	The relative contribution of promoter hypermethylation and aberrant splicing to the inactivation of the fragile histidine triad (FHIT) gene is unclear.	Histidine	112-121	fragile histidine triad diadenosine triphosphatase	Homo sapiens	129-133
15181008-3	2004	Mutation of His-10 in PGM abolishes the Nm23-H1.GAPDH complex-induced phosphorylation.	Histidine	12-15	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	40-47
8972223-5	1997	In the C terminus of the IGF-I receptor, two mutations, one at tyrosine 1251 and one which replaced residues histidine 1293 and lysine 1294, abolished the antiapoptotic function, whereas mutation of the four serines at 1280 to 1283 did not.	Histidine	109-118	insulin-like growth factor 1 receptor	Rattus norvegicus	25-39
17428396-9	2007	The polyclonal anti-His-RPS13 antibody was obtained by immunizing the mice with RPS13 protein.	Histidine	20-23	ribosomal protein S13	Mus musculus	80-85
8961563-4	1996	The histidine-tagged RepC retains its initiation and topoisomerase activities in vitro.	Histidine	4-13	RepC	Staphylococcus aureus	21-25
8955402-1	1996	Selection for the ability of Saccharomyces cerevisiae cells to take up histidinol, the biosynthetic precursor to histidine, results in dominant mutations at HOL1.	Histidine	113-122	Hol1p	Saccharomyces cerevisiae S288C	157-161
17428396-11	2007	CONCLUSION: RPS13 has bene expressed and purified successfully and polyclonal anti-His-RPS13 antibody has been prepared.	Histidine	83-86	ribosomal protein S13	Mus musculus	87-92
17428396-12	2007	Our study can be used for the preparation of monoclonal anti-His-RPS13 antibody and for further research of the function of the RPS13 protein in tumor.	Histidine	61-64	ribosomal protein S13	Mus musculus	65-70
17428396-12	2007	Our study can be used for the preparation of monoclonal anti-His-RPS13 antibody and for further research of the function of the RPS13 protein in tumor.	Histidine	61-64	ribosomal protein S13	Mus musculus	128-133
17170198-2	2007	By introducing a His residue at position III:05 in the CXCR3 receptor a metal ion site was built between the extracellular ends of transmembrane (TM) III and TM-IV to anchor aromatic chelators at a location corresponding to the presumed binding pocket for adrenergic receptor agonists.	Histidine	17-20	C-X-C motif chemokine receptor 3	Homo sapiens	55-60
8808595-2	1996	Two unrelated CDGS type II patients are shown to have point mutations (one patient having Ser-->Phe and the other having His-->Arg) in the catalytic domain of the gene MGAT2, encoding UDP-GlcNAc:alpha-6-D-mannoside beta-1,2-N- acetylglucosaminyltransferase II (GnT II), an enzyme essential for biosynthesis of complex Asn-linked glycans.	Histidine	121-124	alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Homo sapiens	168-173
8828480-14	1996	The mechanism of the specificity "switch" remains to be elucidated, but may result from a subtle perturbation of the bioactive conformation and/or from a direct steric hindrance at the hPTH2 receptor-ligand interface created by histidine at position 5.	Histidine	228-237	parathyroid hormone 2	Homo sapiens	185-190
15246872-1	2004	Fhit protein is the product of the putative tumor suppressor fragile histidine triad (FHIT) gene.	Histidine	69-78	fragile histidine triad diadenosine triphosphatase	Homo sapiens	0-4
15246872-1	2004	Fhit protein is the product of the putative tumor suppressor fragile histidine triad (FHIT) gene.	Histidine	69-78	fragile histidine triad diadenosine triphosphatase	Homo sapiens	86-90
8841182-2	1996	We now report that an Arg-His substitution at residue 117 of the cationic trypsinogen gene is associated with the HP phenotype.	Histidine	26-29	serine protease 1	Homo sapiens	65-85
17242203-4	2007	In contrast, an activated His(6)-GFP-Atrop6(CA) mutant protein accumulated exclusively in detergent-resistant membranes.	Histidine	26-29	RAC-like 3	Arabidopsis thaliana	37-43
8863827-6	1996	Induction of a pheromone-responsive FUS1-HIS3 reporter gene in far1 his3 cells permits cell growth in medium lacking histidine.	Histidine	117-126	Fus1p	Saccharomyces cerevisiae S288C	36-40
15356332-7	2004	The purified ARR22 protein had the ability to undergo phosphorylation in vitro, when incubated with phospho-AHP5, indicating that ARR22 has the fundamental ability to participate into a His-Asp phosphorelay pathway in its own right.	Histidine	186-189	response regulator 22	Arabidopsis thaliana	13-18
17242203-10	2007	In agreement, activated His(6)-GFP-Atrop6(CA)mS(156) in which cysteine(156) was mutated into serine accumulated in Triton-soluble membranes.	Histidine	24-27	RAC-like 3	Arabidopsis thaliana	35-41
17306029-5	2007	Unexpectedly, we find that His-950 in human MR, which is conserved in the MR in chimpanzee, orangutan and macaque, is glutamine in all teleost and land vertebrate MRs, including New World monkeys and prosimians.	Histidine	27-30	nuclear receptor subfamily 3 group C member 2	Homo sapiens	44-46
15189499-1	2004	Previously we demonstrated that histidine decarboxylase (HDC), which produces histamine from l-histidine, was detected in monocytes/macrophages located in human atherosclerotic lesions.	Histidine	93-104	histidine decarboxylase	Homo sapiens	32-55
15189499-1	2004	Previously we demonstrated that histidine decarboxylase (HDC), which produces histamine from l-histidine, was detected in monocytes/macrophages located in human atherosclerotic lesions.	Histidine	93-104	histidine decarboxylase	Homo sapiens	57-60
8872162-9	1996	Another point mutation in the CDR2 region of BV17S1, which results in the amino acid replacement of Gln by His, originally identified form a cDNA clone, has now been confirmed as an allele by ARMS analysis using genomic DNA preparations and designated to as BV17S1*3.	Histidine	107-110	cerebellar degeneration related protein 2	Homo sapiens	30-34
17306029-5	2007	Unexpectedly, we find that His-950 in human MR, which is conserved in the MR in chimpanzee, orangutan and macaque, is glutamine in all teleost and land vertebrate MRs, including New World monkeys and prosimians.	Histidine	27-30	nuclear receptor subfamily 3 group C member 2	Homo sapiens	74-76
8812499-3	1996	HKE4 may encode a membrane protein with histidine-rich charge clusters.	Histidine	40-49	solute carrier family 39 member 7	Homo sapiens	0-4
17306029-7	2007	A mutation corresponding to His-950 in human MR may have been important in physiological changes associated with emergence of Old World monkeys from prosimians.	Histidine	28-31	nuclear receptor subfamily 3 group C member 2	Homo sapiens	45-47
15100231-8	2004	Electrophysiological studies using 80K-H mutants showed that three domains of 80K-H (the two EF-hand structures, the highly acidic glutamic stretch, and the His-Asp-Glu-Leu sequence) are critical determinants for TRPV5 activity.	Histidine	157-160	transient receptor potential cation channel subfamily V member 5	Homo sapiens	213-218
17005605-0	2007	Transmembrane domain histidines contribute to regulation of AE2-mediated anion exchange by pH.	Histidine	21-31	solute carrier family 4 (anion exchanger), member 2	Mus musculus	60-63
15135396-6	2004	Proteins were purified as the p85alpha/p110 complex by nickel affinity chromatography through an N-terminal His-tag on the p110 subunit using an imidazole gradient.	Histidine	108-111	endogenous retrovirus group K member 15	Homo sapiens	39-43
8659121-5	1996	In vitro phosphorylation of recombinant VSV P protein could be enhanced in MxA-negative cell extracts after exogenous addition of recombinant His-MxA.	Histidine	142-145	MX dynamin like GTPase 1	Homo sapiens	75-78
8659121-5	1996	In vitro phosphorylation of recombinant VSV P protein could be enhanced in MxA-negative cell extracts after exogenous addition of recombinant His-MxA.	Histidine	142-145	MX dynamin like GTPase 1	Homo sapiens	146-149
15134452-5	2004	TMX-3 has two important structural features: a proline residue in the hydrophobic core that discourages the formation of highly helical aggregates in solution and two histidine residues that allow control of membrane and solution interactions by means of pH changes.	Histidine	167-176	thioredoxin related transmembrane protein 3	Homo sapiens	0-5
8621548-5	1996	In addition, p300 is able to interact both in vivo and in vitro with MyoD through a portion at the carboxyl-terminal cysteine/histidine-rich domain and associates with the components of the basal transcriptional complex through its two separate transactivation domains at the amino and carboxyl termini.	Histidine	126-135	E1A binding protein p300	Homo sapiens	13-17
17005605-3	2007	We have investigated the importance to pH sensitivity of the eight histidine (His) residues within the AE2 COOH-terminal transmembrane domain (TMD).	Histidine	67-76	solute carrier family 4 (anion exchanger), member 2	Mus musculus	103-106
15134452-6	2004	The partitioning of TMX-3 into membranes followed complex kinetics, induced helicity, and shifted the histidine pK(a) from 6.8 to approximately 6.	Histidine	102-111	thioredoxin related transmembrane protein 3	Homo sapiens	20-25
15134452-9	2004	The free energies of IF partitioning of TMX-3 with deprotonated (pH 7.6) and protonated histidines (pH 4.5) were estimated by fluorescence titration to be -6.7 and -5.0 kcal/mol, respectively.	Histidine	88-98	thioredoxin related transmembrane protein 3	Homo sapiens	40-45
17005605-3	2007	We have investigated the importance to pH sensitivity of the eight histidine (His) residues within the AE2 COOH-terminal transmembrane domain (TMD).	Histidine	78-81	solute carrier family 4 (anion exchanger), member 2	Mus musculus	103-106
8627324-7	1996	Participation by system ASC was indicated by trans-acceleration of Na+ -dependent uptake, preferential inhibition of an Li+ -intolerant component of uptake by cysteine, and inhibition by cysteine of a component resistant to inhibition by histidine and alpha-(methylamino) isobutyric acid.	Histidine	238-247	steroid sulfatase	Mus musculus	24-27
17005605-10	2007	The simultaneous mutation of five or more His residues, however, greatly decreased basal AE2 activity, consistent with the inhibitory effects of DEPC modification.	Histidine	42-45	solute carrier family 4 (anion exchanger), member 2	Mus musculus	89-92
17005605-11	2007	The results show that multiple TMD His residues contribute to basal AE2 activity and its sensitivity to pH(i) and pH(o).	Histidine	35-38	solute carrier family 4 (anion exchanger), member 2	Mus musculus	68-71
24557626-1	2007	We detected loss of heterozygosity (LOH) and microsatellite instabilities (MSI), as well as extron expression of the fragile histidine triad (FHIT) gene in gastric carcinoma (GC), in order to evaluate their association with clinicopathological processes in gastric carcinogenesis.	Histidine	125-134	fragile histidine triad diadenosine triphosphatase	Homo sapiens	142-146
8642596-1	1996	The distal histidine residue, His64(E7), and the proximal histidine residue, His93(F8), in myoglobin (Mb) are important for the function of the protein.	Histidine	11-20	myoglobin	Physeter catodon	91-100
8642596-1	1996	The distal histidine residue, His64(E7), and the proximal histidine residue, His93(F8), in myoglobin (Mb) are important for the function of the protein.	Histidine	58-67	myoglobin	Physeter catodon	91-100
15128298-6	2004	The coding sequences were expressed in Escherichia coli as six-histidine tagged recombinant proteins and generated products with molecular masses of 86.1 kDa for HSP and 22.4 kDa for MnSOD.	Histidine	63-72	superoxide dismutase 2	Homo sapiens	183-188
15078916-6	2004	In the killifish AQP0 homologue, MIPfun, with His at position 39 in loop A, alkaline rather than acid pH increased water permeability.	Histidine	46-49	major intrinsic protein of lens fiber	Bos taurus	17-21
17137614-0	2007	Abnormal fragile histidine triad (Fhit) expression in invasive cervical adenocarcinoma: association with tumor aggressiveness.	Histidine	17-26	fragile histidine triad diadenosine triphosphatase	Homo sapiens	34-38
15096035-1	2004	Cu-Zn superoxide dismutase (SOD) contains a conserved, metal-free His residue at an opening of the backbone beta-barrel in addition to six Cu- and/or Zn-bound His residues in the active site.	Histidine	66-69	superoxide dismutase [Cu-Zn]	Bos taurus	0-26
15096035-1	2004	Cu-Zn superoxide dismutase (SOD) contains a conserved, metal-free His residue at an opening of the backbone beta-barrel in addition to six Cu- and/or Zn-bound His residues in the active site.	Histidine	159-162	superoxide dismutase [Cu-Zn]	Bos taurus	0-26
15047186-3	2004	For development of high-throughput P450 substrate profiling procedures, membrane proteins derived from cells overexpressing CYP73A5 and/or NADPH P450 reductase were incorporated into soluble His(6)-tagged nanoscale lipid bilayers (Nanodiscs) using a simple self-assembly process.	Histidine	191-194	cinnamate-4-hydroxylase	Arabidopsis thaliana	124-131
8547339-15	1996	We propose that mouse CPO is copper-containing enzyme and Cu2+ interacts with a conserved histidine residue.	Histidine	90-99	immunoglobulin kappa variable 1-35	Mus musculus	58-61
8899819-2	1996	Ac-Ser.Tyr-Ser-Nle4-Glu- His-DPhe7-Arg-Trp-Gly-Lys-Pro-Val-NH2(NDP-MSH), led to the discovery of tripeptide agonists possessing prolonged bioactivity in the frog skin assay.	Histidine	25-28	norrin cystine knot growth factor NDP	Homo sapiens	63-66
17137614-1	2007	The fragile histidine triad (FHIT) gene is a candidate tumor suppressor gene.	Histidine	12-21	fragile histidine triad diadenosine triphosphatase	Homo sapiens	29-33
17085448-0	2007	Residues His-15 and Arg-17 of HPr participate differently in catabolite signal processing via CcpA.	Histidine	9-12	haptoglobin-related protein	Homo sapiens	30-33
8537336-5	1995	A close comparison with the human P2Y2 sequence reveals the conservation of histidine 262, arginine 265, lysine 289, and arginine 292, which were reported to be involved in nucleotide binding (Erb, L., Garrad, R., Wang, Y., Quinn, T., Turner, J. T., and Weisman, G. A.	Histidine	76-85	estrogen receptor 2	Homo sapiens	193-196
14766940-3	2004	Two important charge differences in beta-TM compared to alpha-TM are the exchange of serine and histidine at positions 229 and 276 with glutamic acid and asparagine, respectively, imparting a more negative charge to beta-TM relative to alpha-TM.	Histidine	96-105	tropomyosin 1, alpha	Mus musculus	56-64
14766940-3	2004	Two important charge differences in beta-TM compared to alpha-TM are the exchange of serine and histidine at positions 229 and 276 with glutamic acid and asparagine, respectively, imparting a more negative charge to beta-TM relative to alpha-TM.	Histidine	96-105	tropomyosin 1, alpha	Mus musculus	236-244
17609851-1	2007	The fragile histidine triad (FHIT), which was located on chromosome 3p14.2, was currently considered a promising candidate for a tumor suppressor gene.	Histidine	12-21	fragile histidine triad diadenosine triphosphatase	Homo sapiens	29-33
14699117-0	2004	Role of the histidine triad-like motif in nucleotide hydrolysis by the rotavirus RNA-packaging protein NSP2.	Histidine	12-21	reticulon 2	Homo sapiens	103-107
14699117-3	2004	Comparison of x-ray structures has revealed significant structural homology between NSP2 and the histidine triad (HIT) family of nucleotidyl hydrolases, which in turn has suggested the location of the active site for NTP hydrolysis in NSP2.	Histidine	97-106	reticulon 2	Homo sapiens	84-88
14699117-3	2004	Comparison of x-ray structures has revealed significant structural homology between NSP2 and the histidine triad (HIT) family of nucleotidyl hydrolases, which in turn has suggested the location of the active site for NTP hydrolysis in NSP2.	Histidine	97-106	reticulon 2	Homo sapiens	235-239
8522591-3	1995	Expression of K18 arg89--&gt;his/cys and its normal K8 partner in cultured cells resulted in punctate staining as compared with the typical filaments obtained after expression of wild-type K8/18.	Histidine	29-32	keratin 18	Mus musculus	14-17
8825099-2	1995	This class of bacterial sensory kinases, typified by ArcB and BarA, possesses two phospho-donor (His) sites, together with a phospho-accepting (Asp) site.	Histidine	97-100	lin-9 DREAM MuvB core complex component	Homo sapiens	62-66
17726229-1	2007	Lipopolysaccharide (LPS) is a proinflammatory and depressogenic agent whereas thyrotropin-releasing hormone (TRH; pGlu-His-Pro-NH2) is an endogenous antidepressant and neuroprotective peptide.	Histidine	119-122	thyrotropin releasing hormone	Rattus norvegicus	78-107
8772237-2	1995	A polymorphism at amino acid 131 [arginine (Arg) or histidine (His)] of Fc gamma RIIa was first shown to be determinant for MoAb-IgG1 binding on monocytes.	Histidine	52-61	Fc gamma receptor IIa	Homo sapiens	72-85
8772237-2	1995	A polymorphism at amino acid 131 [arginine (Arg) or histidine (His)] of Fc gamma RIIa was first shown to be determinant for MoAb-IgG1 binding on monocytes.	Histidine	63-66	Fc gamma receptor IIa	Homo sapiens	72-85
8772237-3	1995	To clarify the role of this polymorphism in platelet activation by MoAb-IgG1 we (i) established the Fc gamma RIIa polymorphism at the gene level by adapting the denaturating gradient gel electrophoresis method, (ii) analyzed the binding affinity of the MoAbs to Fc gamma RIIa on platelets from homozygous Arg, homozygous His, and heterozygous Arg/His donors, and (iii) characterized the different reactivities of platelets according to the Fc gamma RIIA polymorphism.	Histidine	321-324	Fc gamma receptor IIa	Homo sapiens	100-113
8772237-3	1995	To clarify the role of this polymorphism in platelet activation by MoAb-IgG1 we (i) established the Fc gamma RIIa polymorphism at the gene level by adapting the denaturating gradient gel electrophoresis method, (ii) analyzed the binding affinity of the MoAbs to Fc gamma RIIa on platelets from homozygous Arg, homozygous His, and heterozygous Arg/His donors, and (iii) characterized the different reactivities of platelets according to the Fc gamma RIIA polymorphism.	Histidine	347-350	Fc gamma receptor IIa	Homo sapiens	100-113
14672930-3	2004	We systematically mutated all the histidine and cysteine residues in Sdh3p and Sdh4p to identify the residues involved in axial heme ligation.	Histidine	34-43	succinate dehydrogenase cytochrome b subunit SDH3	Saccharomyces cerevisiae S288C	69-74
14672930-5	2004	Mutation of Sdh3p His-46 or His-113 leads to a marked reduction in the catalytic efficiency of the enzyme for quinone reduction, suggesting that these residues form part of a quinone-binding site.	Histidine	18-21	succinate dehydrogenase cytochrome b subunit SDH3	Saccharomyces cerevisiae S288C	12-17
14672930-6	2004	We identified Sdh3p His-106 and Sdh4p Cys-78 as the most probable axial ligands for cytochrome b(562).	Histidine	20-23	succinate dehydrogenase cytochrome b subunit SDH3	Saccharomyces cerevisiae S288C	14-19
14672930-6	2004	We identified Sdh3p His-106 and Sdh4p Cys-78 as the most probable axial ligands for cytochrome b(562).	Histidine	20-23	cytochrome b	Saccharomyces cerevisiae S288C	84-96
14672930-7	2004	Replacement of His-106 or Cys-78 with an alanine residue leads to a marked reduction in cytochrome b(562) content and to altered heme spectral characteristics that are consistent with a direct perturbation of heme b environment.	Histidine	15-18	cytochrome b	Saccharomyces cerevisiae S288C	88-100
17726229-1	2007	Lipopolysaccharide (LPS) is a proinflammatory and depressogenic agent whereas thyrotropin-releasing hormone (TRH; pGlu-His-Pro-NH2) is an endogenous antidepressant and neuroprotective peptide.	Histidine	119-122	thyrotropin releasing hormone	Rattus norvegicus	109-112
8555090-2	1995	A single base polymorphism at position 131 of Fc gamma RIIA changes the native arginine to histidine.	Histidine	91-100	Fc gamma receptor IIa	Homo sapiens	46-59
17140699-9	2007	A novel corazonin form, [His(4), Gln(7)]-corazonin, was also detected in all South African members of the newly described insect order Mantophasmatodea.	Histidine	25-28	pro-corazonin	Apis mellifera	8-17
17140699-9	2007	A novel corazonin form, [His(4), Gln(7)]-corazonin, was also detected in all South African members of the newly described insect order Mantophasmatodea.	Histidine	25-28	pro-corazonin	Apis mellifera	41-50
17140699-10	2007	The [His(4), Gln(7)]-corazonin separates these species from the Namibian Mantophasmatodea which express [Arg(7)]-corazonin and can be used as a distinct character to distinguish these morphologically similar insects.	Histidine	5-8	pro-corazonin	Apis mellifera	21-30
8710835-0	1995	Homology modeling of histidine-containing phosphocarrier protein and eosinophil-derived neurotoxin: construction of models and comparison with experiment.	Histidine	21-30	ribonuclease A family member 2	Homo sapiens	69-98
17068338-5	2006	At the second nucleotide binding site, a glutamic acid (TAP2 Glu(632)) follows the Walker B motif, and the switch region contains a histidine (TAP2 His(661)).	Histidine	132-141	transporter 2, ATP binding cassette subfamily B member	Homo sapiens	143-147
15025965-0	2004	[Abnormal expression of fragile histidine triad (FHIT) and Mut S homolog 2 (MSH2) proteins in human sporadic colorectal carcinoma and their clinical significance].	Histidine	32-41	fragile histidine triad diadenosine triphosphatase	Homo sapiens	49-53
15025965-1	2004	BACKGROUND &amp; OBJECTIVE: Frequent loss of fragile histidine triad (FHIT) expression in human gastrointestinal tract carcinomas has been reported; however, there were divergent opinions regarding FHIT expression in colorectal carcinoma.	Histidine	53-62	fragile histidine triad diadenosine triphosphatase	Homo sapiens	70-74
17068338-5	2006	At the second nucleotide binding site, a glutamic acid (TAP2 Glu(632)) follows the Walker B motif, and the switch region contains a histidine (TAP2 His(661)).	Histidine	148-151	transporter 2, ATP binding cassette subfamily B member	Homo sapiens	143-147
15025965-1	2004	BACKGROUND &amp; OBJECTIVE: Frequent loss of fragile histidine triad (FHIT) expression in human gastrointestinal tract carcinomas has been reported; however, there were divergent opinions regarding FHIT expression in colorectal carcinoma.	Histidine	53-62	fragile histidine triad diadenosine triphosphatase	Homo sapiens	198-202
15134829-5	2004	A low cell-free endosome-lysosome transfer of the internalized IR was only observed in response to HI and H2-analogue injection.	Histidine	99-101	insulin receptor	Rattus norvegicus	63-65
17068338-6	2006	We found that alterations at Glu(632) and His(661) of TAP2 significantly reduced peptide translocation and/or TAP-induced major histocompatibility complex class I surface expression.	Histidine	42-45	transporter 2, ATP binding cassette subfamily B member	Homo sapiens	54-58
17046815-6	2006	VGLUT2s with mutations in the transmembrane-located residues Arg(184), His(128), and Glu(191) showed a dramatic loss in l-glutamate transport activity, whereas Na(+)-dependent inorganic phosphate (P(i)) uptake remained comparable to that of the wild type.	Histidine	71-74	solute carrier family 17 member 6	Homo sapiens	0-6
15071908-1	2004	OBJECTIVE: To study the expression of fragile histidine triad (FHIT) protein in rhabdomyosarcoma(RMS) and the possible mechanisms of its effect on tumor.	Histidine	46-55	fragile histidine triad diadenosine triphosphatase	Homo sapiens	63-67
7577928-1	1995	To test the hypothesis that pGlu of the thyrotropin-releasing hormone (TRH, pGlu-His-ProNH2) binds to Asn289 in the third extracellular loop (EL3) of its receptor through a hydrogen bonding interaction, we converted Asn289 to Asp (N289D mutant) and measured the potencies of TRH and Pro1TRH for the wild-type and mutant receptors.	Histidine	81-84	thyrotropin releasing hormone	Rattus norvegicus	40-69
7577928-1	1995	To test the hypothesis that pGlu of the thyrotropin-releasing hormone (TRH, pGlu-His-ProNH2) binds to Asn289 in the third extracellular loop (EL3) of its receptor through a hydrogen bonding interaction, we converted Asn289 to Asp (N289D mutant) and measured the potencies of TRH and Pro1TRH for the wild-type and mutant receptors.	Histidine	81-84	thyrotropin releasing hormone	Rattus norvegicus	71-74
7577928-1	1995	To test the hypothesis that pGlu of the thyrotropin-releasing hormone (TRH, pGlu-His-ProNH2) binds to Asn289 in the third extracellular loop (EL3) of its receptor through a hydrogen bonding interaction, we converted Asn289 to Asp (N289D mutant) and measured the potencies of TRH and Pro1TRH for the wild-type and mutant receptors.	Histidine	81-84	thyrotropin releasing hormone	Rattus norvegicus	275-278
16788146-3	2006	In the present study, histidine-tagged hRS1 was expressed in oocytes or Sf9 cells and purified using nickel(II)-charged nitrilotriacetic acid-agarose.	Histidine	22-31	retinoschisin 1	Homo sapiens	39-43
7664666-2	1995	Rat pro-TRH contains five copies of the TRH progenitor sequence (Gln-His-Pro-Gly) and seven other cryptic peptides.	Histidine	69-72	thyrotropin releasing hormone	Rattus norvegicus	4-11
7559398-5	1995	Furthermore, activated His-tagged Cdc42Hs and His-tagged Rac stimulate mPAK-3 autophosphorylation and phosphorylation of myelin basic protein by mPAK-3 in vitro.	Histidine	23-26	p21 (RAC1) activated kinase 3	Mus musculus	71-77
7559398-5	1995	Furthermore, activated His-tagged Cdc42Hs and His-tagged Rac stimulate mPAK-3 autophosphorylation and phosphorylation of myelin basic protein by mPAK-3 in vitro.	Histidine	23-26	myelin basic protein	Mus musculus	121-141
7559398-5	1995	Furthermore, activated His-tagged Cdc42Hs and His-tagged Rac stimulate mPAK-3 autophosphorylation and phosphorylation of myelin basic protein by mPAK-3 in vitro.	Histidine	23-26	p21 (RAC1) activated kinase 3	Mus musculus	145-151
7559398-5	1995	Furthermore, activated His-tagged Cdc42Hs and His-tagged Rac stimulate mPAK-3 autophosphorylation and phosphorylation of myelin basic protein by mPAK-3 in vitro.	Histidine	46-49	Rac family small GTPase 1	Mus musculus	57-60
7559398-5	1995	Furthermore, activated His-tagged Cdc42Hs and His-tagged Rac stimulate mPAK-3 autophosphorylation and phosphorylation of myelin basic protein by mPAK-3 in vitro.	Histidine	46-49	p21 (RAC1) activated kinase 3	Mus musculus	71-77
15067734-1	2004	OBJECTIVE: To investigate the effect of fragile histidine triad (FHIT) gene on the apoptosis of gastric cancer cells.	Histidine	48-57	fragile histidine triad diadenosine triphosphatase	Homo sapiens	65-69
17125395-1	2006	X-ray analyses of matrix metalloproteinases (MMPs) have shown that the catalytic zinc ion (Zn1) can bind to one to three water molecules in addition to three conserved histidine residues.	Histidine	168-177	matrix metallopeptidase 2	Homo sapiens	45-49
14697262-5	2004	One is F455W whose homologous position in Torped AChE (Phe331) is located in the vicinity of the catalytic His in the acyl pocket of the active site gorge.	Histidine	107-110	Acetylcholine esterase	Drosophila melanogaster	49-53
7559398-5	1995	Furthermore, activated His-tagged Cdc42Hs and His-tagged Rac stimulate mPAK-3 autophosphorylation and phosphorylation of myelin basic protein by mPAK-3 in vitro.	Histidine	46-49	myelin basic protein	Mus musculus	121-141
7559398-5	1995	Furthermore, activated His-tagged Cdc42Hs and His-tagged Rac stimulate mPAK-3 autophosphorylation and phosphorylation of myelin basic protein by mPAK-3 in vitro.	Histidine	46-49	p21 (RAC1) activated kinase 3	Mus musculus	145-151
7559470-2	1995	Both diphtheria toxin and Pseudomonas exotoxin A inhibit eukaryotic protein synthesis by ADP-ribosylating diphthamide, a posttranslationally modified histidine residue present in the elongation factor 2 (EF-2) protein.	Histidine	150-159	elongation factor 2	Cricetulus griseus	183-202
7559470-2	1995	Both diphtheria toxin and Pseudomonas exotoxin A inhibit eukaryotic protein synthesis by ADP-ribosylating diphthamide, a posttranslationally modified histidine residue present in the elongation factor 2 (EF-2) protein.	Histidine	150-159	elongation factor 2	Cricetulus griseus	204-208
7559470-3	1995	Elongation factor 2 cannot be ADP-ribosylated by the toxins unless this histidine is modified.	Histidine	72-81	elongation factor 2	Cricetulus griseus	0-19
17125395-5	2006	On the other hand, B3LYP/OPLS-AA hybrid QM/molecular mechanical calculations in the solvated catalytic domain of the MMP-2 enzyme complemented with electrostatic Poisson-Boltzmann calculations show that the mature enzyme presents most likely a Zn1 ion coordinated by three histidine residues and two water molecules, while the active site glutamic acid is negatively charged.	Histidine	273-282	matrix metallopeptidase 2	Homo sapiens	117-122
17119051-1	2006	BACKGROUND: In a retrospective analysis of 195 patients with small cell lung cancer (SCLC), we examined the prognostic value of a coexpression of fragile histidine triad (FHIT) protein and c-kit on patient"s survival.	Histidine	154-163	fragile histidine triad diadenosine triphosphatase	Homo sapiens	171-175
7556671-2	1995	Deduced from its nucleotide sequence, PDIR has the three CXXC-like motifs (Cys-Ser-Met-Cys, Cys-Gly-His-Cys and Cys-Pro-His-Cys), which are found in proteins within the PDI superfamily and are responsible for oxidoreductase activity.	Histidine	100-103	protein disulfide isomerase family A member 5	Homo sapiens	38-42
7556671-2	1995	Deduced from its nucleotide sequence, PDIR has the three CXXC-like motifs (Cys-Ser-Met-Cys, Cys-Gly-His-Cys and Cys-Pro-His-Cys), which are found in proteins within the PDI superfamily and are responsible for oxidoreductase activity.	Histidine	120-123	protein disulfide isomerase family A member 5	Homo sapiens	38-42
7665595-7	1995	NDPK phosphorylated the histidine at the catalytic site of ATP-citrate lyase.	Histidine	24-33	ATP citrate lyase	Rattus norvegicus	59-76
7665595-8	1995	This histidine can also be phosphorylated by ATP, and its phosphorylation is the first step in the conversion of citrate and CoA to oxaloacetate and acetyl-CoA by ATP-citrate lyase.	Histidine	5-14	ATP citrate lyase	Rattus norvegicus	163-180
14525539-3	2004	Amino acid sequence alignments identified a conserved histidine residue located in the putative phosphohistidine domain of potato GWD.	Histidine	54-63	alpha-glucan water dikinase, chloroplastic	Solanum tuberosum	130-133
16735073-4	2006	In order to obtain human LOX-1 and identify its mimic ligand for facilitating the study of LOX-1 function, a recombinant plasmid pPIC9K-His-hLOX-1 was structured and expressed human LOX-1 in Pichia pastoris GS115.	Histidine	136-139	oxidized low density lipoprotein receptor 1	Homo sapiens	25-30
14605231-3	2003	One of the isolated mutants, eid6, is a novel recessive allele of the COP1 gene (constitutive photomorphogenic 1) that carries an amino acid transition in a conserved histidine residue of the RING finger domain.	Histidine	167-176	Transducin/WD40 repeat-like superfamily protein	Arabidopsis thaliana	70-74
14656441-2	2003	YPD1 functions as a histidine-phosphorylated protein intermediate required for phosphoryl group transfer from a membrane-bound sensor histidine kinase (SLN1) to two distinct response regulator proteins (SSK1 and SKN7).	Histidine	20-29	Ypd1p	Saccharomyces cerevisiae S288C	0-4
17075268-1	2006	BACKGROUND: Histamine synthesized by histidine decarboxylase (HDC) from L-histidine is a major chemical mediator in the development of nasal allergy which is characterized by nasal hypersensitivity.	Histidine	72-83	histidine decarboxylase	Rattus norvegicus	37-60
14656441-2	2003	YPD1 functions as a histidine-phosphorylated protein intermediate required for phosphoryl group transfer from a membrane-bound sensor histidine kinase (SLN1) to two distinct response regulator proteins (SSK1 and SKN7).	Histidine	20-29	histidine kinase	Saccharomyces cerevisiae S288C	152-156
14656441-5	2003	Here we report the first crystal structure of a prototypical monomeric histidine-containing phosphotransfer (HPt) protein YPD1 in complex with its upstream phosphodonor, the response regulator domain associated with SLN1.	Histidine	71-80	Ypd1p	Saccharomyces cerevisiae S288C	122-126
14656441-5	2003	Here we report the first crystal structure of a prototypical monomeric histidine-containing phosphotransfer (HPt) protein YPD1 in complex with its upstream phosphodonor, the response regulator domain associated with SLN1.	Histidine	71-80	histidine kinase	Saccharomyces cerevisiae S288C	216-220
12959987-7	2003	However, l-His potentiates cAMP response element reporter activity in INS-1 cells and in human embryonic kidney-293 cells expressing either the GLP-1R alone or the CaSR and GLP-1R.	Histidine	9-14	glucagon like peptide 1 receptor	Homo sapiens	144-150
12959987-7	2003	However, l-His potentiates cAMP response element reporter activity in INS-1 cells and in human embryonic kidney-293 cells expressing either the GLP-1R alone or the CaSR and GLP-1R.	Histidine	9-14	glucagon like peptide 1 receptor	Homo sapiens	173-179
14733360-6	2003	The coactivator recruitment assay for FXR activation was carried out with the three variants of the FXR protein by using dissociation-enhanced lanthanide fluoroimmunoassay-europium-N1-labeled anti-His antibody.	Histidine	197-200	nuclear receptor subfamily 1 group H member 4	Homo sapiens	38-41
14733360-6	2003	The coactivator recruitment assay for FXR activation was carried out with the three variants of the FXR protein by using dissociation-enhanced lanthanide fluoroimmunoassay-europium-N1-labeled anti-His antibody.	Histidine	197-200	nuclear receptor subfamily 1 group H member 4	Homo sapiens	100-103
14638866-2	2003	Because the fragile histidine triad (FHIT) gene, a tumor suppressor gene encompassing the most active, common fragile site FRA3B, is frequently deleted in various cancers, we evaluated the expression of WWOX and FHIT in 74 cases of primary hematopoietic neoplasias and 20 leukemia cell lines.	Histidine	20-29	fragile histidine triad diadenosine triphosphatase	Homo sapiens	37-41
12869545-2	2003	We generated mice with a point mutation in the thyroid hormone receptor alpha (TRalpha) gene producing a dominant-negative TRalpha mutant receptor with a proline to histidine substitution (P398H).	Histidine	165-174	thyroid hormone receptor alpha	Mus musculus	47-77
12869563-4	2003	These data indicate that ectodomain cleavage of ErbB-4 occurs between His-651 and Ser-652, placing the cleavage site within the ectodomain stalk region approximately 8 residues prior to the transmembrane domain.	Histidine	70-73	erb-b2 receptor tyrosine kinase 4	Homo sapiens	48-54
12940738-5	2003	The splicing product MBP-His was detected by Western blotting and immunoprecipitation in cells treated with rapamycin or a nontoxic analogue thereof.	Histidine	25-28	myelin basic protein	Homo sapiens	21-24
12924932-12	2003	Given the calculated protein-induced E(m) shift and measured cytochrome E(m) the five-coordinate, His heme in c" is predicted to have a solution E(m) between that of isolated bis-His and His-Met hemes, while the reference E(m) for His-Ntr ligands in cytochrome f should be near that of His-Met hemes.	Histidine	98-101	neurotensin receptor 1	Homo sapiens	235-238
12893195-1	2003	OBJECTIVE: The fragile histidine triad (FHIT) gene is located at chromosome 3p14.2 and encompasses the common fragile site, FRA3B, which may contribute to chromosome breakage and rearrangement of cancer cells.	Histidine	23-32	fragile histidine triad diadenosine triphosphatase	Homo sapiens	40-44
12893195-1	2003	OBJECTIVE: The fragile histidine triad (FHIT) gene is located at chromosome 3p14.2 and encompasses the common fragile site, FRA3B, which may contribute to chromosome breakage and rearrangement of cancer cells.	Histidine	23-32	fragile histidine triad diadenosine triphosphatase	Homo sapiens	124-129
12966075-4	2003	In particular, the proposed catalytic residues (Ser, Asp, and His) of AARE, called the "catalytic triad residues, " were completely conserved.	Histidine	62-65	acylaminoacyl-peptidase-like protein	Arabidopsis thaliana	70-74
12837291-6	2003	However, the responses of the two templates differ mechanistically in that the CREB-binding protein p300 potentiates activation from the transient template in a manner dependent on its Cys/His-rich region 3, but does not appear to affect the repression of the replicating chromatin template.	Histidine	189-192	E1A binding protein p300	Homo sapiens	100-104
12835493-4	2003	The inhibition of amidolytic plasmin activity by Zn2+ and Cu2+ was reduced in the presence of EDTA, histidine, or albumin.	Histidine	100-109	plasminogen	Homo sapiens	29-36
12800227-1	2003	AIM: To investigate the expression of fragile histidine triad (FHIT) gene protein, Fhit, which is recently thought to be a candidate tumor suppressor.	Histidine	46-55	fragile histidine triad diadenosine triphosphatase	Homo sapiens	63-67
12800227-1	2003	AIM: To investigate the expression of fragile histidine triad (FHIT) gene protein, Fhit, which is recently thought to be a candidate tumor suppressor.	Histidine	46-55	fragile histidine triad diadenosine triphosphatase	Homo sapiens	83-87
12570875-9	2003	Co-immunoprecipitation experiments from Tyr(505) --&gt; Phe/V5-His-expressing cells revealed that LAT preferentially interacts with the "open" form of Lck in T cell raft domains.	Histidine	63-66	linker for activation of T cells	Homo sapiens	98-101
12765029-5	2003	With this system, the NLS-tetR-GFP and DsRed genes were successfully integrated at the thr1 locus, and the RVB1 gene was tagged at the C-terminus with the V5-epitope-6-histidine tag.	Histidine	168-177	RuvB family ATP-dependent DNA helicase pontin	Saccharomyces cerevisiae S288C	107-111
12684778-3	2003	In this study we describe the cloning and expression patterns of a novel gene encoding a protein containing a His-Thr domain, Spot-2.	Histidine	110-113	DNA binding protein with his-thr domain	Mus musculus	126-132
12698186-1	2003	We analysed the expression of the fragile histidine triad (FHIT) gene in cervical cancer to evaluate its clinical relevance in relation to human papillomavirus (HPV) infection.	Histidine	42-51	fragile histidine triad diadenosine triphosphatase	Homo sapiens	59-63
12650996-3	2003	Although individual domains of PRH have been expressed in bacterial cells as GST- and histidine-tagged fusion proteins, attempts to express and purify the full-length protein have met with little success.	Histidine	86-95	hematopoietically expressed homeobox	Homo sapiens	31-34
12650996-4	2003	Here we describe the purification of a histidine-tagged full-length PRH fusion protein.	Histidine	39-48	hematopoietically expressed homeobox	Homo sapiens	68-71
12627943-0	2003	Catalytic and structural effects of amino acid substitution at histidine 30 in human manganese superoxide dismutase: insertion of valine C gamma into the substrate access channel.	Histidine	63-72	superoxide dismutase 2	Homo sapiens	85-115
12614157-3	2003	Nuclear uptake of biotinylated recombinant His-tagged Rev-GFP was assessed in nuclear extracts from digitonin-permeabilized cells by binding to either importin beta-receptors or nickel molecules immobilized on a microtiter plate.	Histidine	43-46	Rev	Human immunodeficiency virus 1	54-57
7543843-2	1995	We have added six histidine residues to the C-terminus of Tif3 protein (Tif3-His6p) and purified the tagged protein by affinity chromatography.	Histidine	18-27	Tif3p	Saccharomyces cerevisiae S288C	58-62
7543843-2	1995	We have added six histidine residues to the C-terminus of Tif3 protein (Tif3-His6p) and purified the tagged protein by affinity chromatography.	Histidine	18-27	Tif3p	Saccharomyces cerevisiae S288C	72-76
7544282-1	1995	The peptide AcAla-Ser-Gln-Lys-Arg-Pro-Ser-Gln-Arg-His-Gly-Ser-Lys-Tyr, which comprises the first 14 residues of the acetylated N-terminus of myelin basic protein, is an epitopic site for two monoclonal antibodies to the human protein.	Histidine	50-53	myelin basic protein	Homo sapiens	141-161
7593830-2	1995	The nature of the interaction of the peptide His98-Pro-His-Pro-His-Leu-Ser-Phe105-Met-Ala-Ile-Pro-Pro- Lys111 with chymosin and porcine pepsin was investigated using molecular modelling and energy minimization techniques.	Histidine	45-48	chymosin	Bos taurus	115-123
7593830-2	1995	The nature of the interaction of the peptide His98-Pro-His-Pro-His-Leu-Ser-Phe105-Met-Ala-Ile-Pro-Pro- Lys111 with chymosin and porcine pepsin was investigated using molecular modelling and energy minimization techniques.	Histidine	55-58	chymosin	Bos taurus	115-123
7542207-1	1995	The histidine at position 1106 of the C4B isotype of human complement is involved in catalyzing the covalent binding of the thioester to glycerol and water.	Histidine	4-13	complement C4B (Chido blood group)	Homo sapiens	38-41
7612603-5	1995	The appearance of a new histidine resonance in the cold-denatured and pressure-denatured RNase A spectra, compared to the absence of this resonance in the heat-denatured state, indicates that the pressure-denatured and cold-denatured states may contain partially folded structures that are similar to that of the early folding intermediate found in the temperature-jump experiment reported by Blum et al.	Histidine	24-33	ribonuclease A family member 1, pancreatic	Homo sapiens	89-96
7630732-9	1995	While most mutations abolish DNA binding, substitution of a histidine residue results in a GCN4 derivative with ATF/CREB binding specificity.	Histidine	60-69	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	91-95
7583761-3	1995	The latter characterized by a unique histidine residue in the zinc binding motif (C2HC5 and C3HC4 for the LIM and RING respectively) may constitute protein/protein interaction interfaces.	Histidine	37-46	PDZ and LIM domain 5	Homo sapiens	106-109
7539429-5	1995	Purified His-MxA exhibited specific GTP hydrolysis rates of up to 350 nmol of GTP/min/mg of protein, corresponding to a turnover number of 27 min-1.	Histidine	9-12	MX dynamin like GTPase 1	Homo sapiens	13-16
7539429-9	1995	Competitive binding studies with nonlabeled nucleotides revealed a similar binding preference of His-MxA for GTP over GDP: the Kd for GTP was 20 microM, whereas the Kd for GDP was 100 microM.	Histidine	97-100	MX dynamin like GTPase 1	Homo sapiens	101-104
7774057-9	1995	Among the anti-F40D monoclonal autoantibodies, one histidine residue located in position 35 of the CDR1 region was constantly found.	Histidine	51-60	cerebellar degeneration related antigen 1	Mus musculus	99-103
7490252-3	1995	To determine whether the sequence of beta-MPP is essential for the enzymatic activity, we individually mutated the histidines and glutamic acid to arginines and glutamine, respectively.	Histidine	115-125	peptidase, mitochondrial processing subunit beta	Rattus norvegicus	37-45
7744838-10	1995	There exist 9 conserved His residues in human G6Pase.	Histidine	24-27	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	46-52
7744838-13	1995	Substitution of His-119 with amino acids of diverse structures also yielded mutant G6Pase with no activity, suggesting that His-119 is the phosphate acceptor in G6Pase catalysis.	Histidine	16-19	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	83-89
7744838-13	1995	Substitution of His-119 with amino acids of diverse structures also yielded mutant G6Pase with no activity, suggesting that His-119 is the phosphate acceptor in G6Pase catalysis.	Histidine	16-19	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	161-167
7744838-13	1995	Substitution of His-119 with amino acids of diverse structures also yielded mutant G6Pase with no activity, suggesting that His-119 is the phosphate acceptor in G6Pase catalysis.	Histidine	124-127	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	83-89
7744838-13	1995	Substitution of His-119 with amino acids of diverse structures also yielded mutant G6Pase with no activity, suggesting that His-119 is the phosphate acceptor in G6Pase catalysis.	Histidine	124-127	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	161-167
7798029-1	1995	TRH-like peptides share the N- and C-terminal amino acids with TRH (pGlu-His-Pro-NH2) but differ in the middle amino acid residue.	Histidine	73-76	thyrotropin releasing hormone	Rattus norvegicus	0-3
7798029-1	1995	TRH-like peptides share the N- and C-terminal amino acids with TRH (pGlu-His-Pro-NH2) but differ in the middle amino acid residue.	Histidine	73-76	thyrotropin releasing hormone	Rattus norvegicus	63-66
15299314-5	1995	A probe model composed of the backbone atoms of the N-terminal 77 residues of lysine-, arginine-, ornithine-binding protein (LAO, a total of 238 residues) liganded with lysine correctly finds its position on LAO liganded with histidine which crystallizes as a monomer in the asymmetric unit.	Histidine	226-235	interleukin 4 induced 1	Homo sapiens	78-123
15299314-5	1995	A probe model composed of the backbone atoms of the N-terminal 77 residues of lysine-, arginine-, ornithine-binding protein (LAO, a total of 238 residues) liganded with lysine correctly finds its position on LAO liganded with histidine which crystallizes as a monomer in the asymmetric unit.	Histidine	226-235	interleukin 4 induced 1	Homo sapiens	125-128
7847389-4	1995	A genomic polymorphism of LMP7 was found strongly associated with IDDM, and the Arg/His-60 polymorphism in LMP2 was found associated with IDDM only in subjects containing an HLA DR4-DQB1*0302 haplotype.	Histidine	84-87	proteasome 20S subunit beta 9	Homo sapiens	107-111
7732725-2	1995	The his1 cDNA was isolated by functional complementation of the His- phenotype in a his1-29 gcn3 Saccharomyces cerevisiae strain, while the his5 cDNA was isolated as a suppressor of the 3-amino-1,2, 4-triazole (3-AT) sensitivity in a gcn3 S. cerevisiae strain.	Histidine	64-67	ATP phosphoribosyltransferase	Saccharomyces cerevisiae S288C	4-8
7837273-5	1995	In Ala68 deoxymyoglobin, as in the wild-type protein, a water molecule hydrogen-bonded to the N epsilon atom of the distal histidine restricts ligand binding and appears to be more important in regulating the function of myoglobin than direct steric interactions between the ligand and the C gamma atoms of the native valine side-chain.	Histidine	123-132	myoglobin	Physeter catodon	14-23
7947969-8	1994	The EPR spectrum of the NO-compound of reduced (ferrous) hCP strongly suggests that the proximal ligand of the heme is the imidazole group of a histidine residue.	Histidine	144-153	coproporphyrinogen oxidase	Homo sapiens	57-60
7853145-1	1994	L-Histidine decarboxylase (HDC) catalyzes the formation of histamine from L-histidine.	Histidine	74-85	histidine decarboxylase	Mus musculus	0-25
7853145-1	1994	L-Histidine decarboxylase (HDC) catalyzes the formation of histamine from L-histidine.	Histidine	74-85	histidine decarboxylase	Mus musculus	27-30
7932578-5	1994	This heterocyclic nitrogen atom would provide a critical hydrogen-bond interaction with the histidine residue of the catalytic triad in PEP.	Histidine	92-101	prolyl endopeptidase	Homo sapiens	136-139
7939659-3	1994	Variants of RNase A were produced in which the catalytic histidines at positions 12 and 119 were substituted with the unnatural amino acid 4-fluorohistidine, which has a pKa of 3.5 compared to 6.8 for histidine.	Histidine	57-67	ribonuclease A family member 1, pancreatic	Homo sapiens	12-19
7939659-3	1994	Variants of RNase A were produced in which the catalytic histidines at positions 12 and 119 were substituted with the unnatural amino acid 4-fluorohistidine, which has a pKa of 3.5 compared to 6.8 for histidine.	Histidine	57-66	ribonuclease A family member 1, pancreatic	Homo sapiens	12-19
7824523-6	1994	Titration of the histidine side chain in NP-2 was examined and the results are mapped to the three-dimensional structure.	Histidine	17-26	corticostatin-4	Oryctolagus cuniculus	41-45
8078898-0	1994	Roles of heme iron-coordinating histidine residues of human hemopexin expressed in baculovirus-infected insect cells.	Histidine	32-41	hemopexin	Homo sapiens	60-69
7519613-11	1994	Histidine-tagged NF45 and NF90 proteins, affinity-purified on nickel chelate columns, encode a NF-AT DNA-binding activity that is enhanced following T-cell stimulation, and this enhancement is blocked when T-cells are stimulated in the presence of cyclosporin A or FK506.	Histidine	0-9	interleukin enhancer binding factor 2	Homo sapiens	17-21
12501240-10	2003	Mutations of any of these histidine residues in GIRK4 or their counterparts in GIRK1 were sufficient to eliminate the pH(i) sensitivity of the heteromeric GIRK1/GIRK4 channels.	Histidine	26-35	potassium inwardly rectifying channel subfamily J member 3	Homo sapiens	79-84
12501240-10	2003	Mutations of any of these histidine residues in GIRK4 or their counterparts in GIRK1 were sufficient to eliminate the pH(i) sensitivity of the heteromeric GIRK1/GIRK4 channels.	Histidine	26-35	potassium inwardly rectifying channel subfamily J member 3	Homo sapiens	155-160
12435745-11	2003	When co-infected with His-tagged UGT1A9, however, part of the HA-tagged enzyme was bound to the column and was eluted by imidazole concentration gradient together with the His-tagged UGT1A9, suggesting the formation of stable dimers that contain one His-tagged and one HA-tagged UGT1A9 monomers.	Histidine	22-25	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	33-39
12435745-11	2003	When co-infected with His-tagged UGT1A9, however, part of the HA-tagged enzyme was bound to the column and was eluted by imidazole concentration gradient together with the His-tagged UGT1A9, suggesting the formation of stable dimers that contain one His-tagged and one HA-tagged UGT1A9 monomers.	Histidine	22-25	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	183-189
12435745-11	2003	When co-infected with His-tagged UGT1A9, however, part of the HA-tagged enzyme was bound to the column and was eluted by imidazole concentration gradient together with the His-tagged UGT1A9, suggesting the formation of stable dimers that contain one His-tagged and one HA-tagged UGT1A9 monomers.	Histidine	22-25	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	183-189
12435745-11	2003	When co-infected with His-tagged UGT1A9, however, part of the HA-tagged enzyme was bound to the column and was eluted by imidazole concentration gradient together with the His-tagged UGT1A9, suggesting the formation of stable dimers that contain one His-tagged and one HA-tagged UGT1A9 monomers.	Histidine	172-175	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	33-39
12435745-11	2003	When co-infected with His-tagged UGT1A9, however, part of the HA-tagged enzyme was bound to the column and was eluted by imidazole concentration gradient together with the His-tagged UGT1A9, suggesting the formation of stable dimers that contain one His-tagged and one HA-tagged UGT1A9 monomers.	Histidine	172-175	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	183-189
12435745-11	2003	When co-infected with His-tagged UGT1A9, however, part of the HA-tagged enzyme was bound to the column and was eluted by imidazole concentration gradient together with the His-tagged UGT1A9, suggesting the formation of stable dimers that contain one His-tagged and one HA-tagged UGT1A9 monomers.	Histidine	172-175	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	183-189
12582120-1	2003	Ypd1p, a histidine-containing phosphotransfer protein, plays an important role in a branched His-Asp phosphorelay signal transduction pathway that regulates cellular responses to hyperosmotic stress in Saccharomyces cerevisiae.	Histidine	9-18	Ypd1p	Saccharomyces cerevisiae S288C	0-5
12582120-1	2003	Ypd1p, a histidine-containing phosphotransfer protein, plays an important role in a branched His-Asp phosphorelay signal transduction pathway that regulates cellular responses to hyperosmotic stress in Saccharomyces cerevisiae.	Histidine	93-96	Ypd1p	Saccharomyces cerevisiae S288C	0-5
12527768-3	2003	Recombinant RNase 7 is ribonucleolytically active against yeast tRNA, as expected from the presence of eight conserved cysteines and the catalytic histidine-lysine- histidine triad which are signature motifs of this superfamily.	Histidine	147-156	ribonuclease A family member 7	Homo sapiens	12-19
12527768-3	2003	Recombinant RNase 7 is ribonucleolytically active against yeast tRNA, as expected from the presence of eight conserved cysteines and the catalytic histidine-lysine- histidine triad which are signature motifs of this superfamily.	Histidine	165-174	ribonuclease A family member 7	Homo sapiens	12-19
12480542-1	2003	The histidine-rich Ca(2+) binding protein (HRC) is a high capacity Ca(2+) binding protein in the sarcoplasmic reticulum (SR).	Histidine	4-13	histidine rich calcium binding protein	Rattus norvegicus	43-46
12455060-2	2003	It has been suggested that the SULT1A1 his (histidine) allele, which is caused by a his for arg (arginine) substitution due to a G--&gt;A transition at codon 213, carries a significantly higher risk for women to develop breast cancer.	Histidine	39-42	sulfotransferase family 1A member 1	Homo sapiens	31-38
12455060-2	2003	It has been suggested that the SULT1A1 his (histidine) allele, which is caused by a his for arg (arginine) substitution due to a G--&gt;A transition at codon 213, carries a significantly higher risk for women to develop breast cancer.	Histidine	44-53	sulfotransferase family 1A member 1	Homo sapiens	31-38
12455060-2	2003	It has been suggested that the SULT1A1 his (histidine) allele, which is caused by a his for arg (arginine) substitution due to a G--&gt;A transition at codon 213, carries a significantly higher risk for women to develop breast cancer.	Histidine	44-47	sulfotransferase family 1A member 1	Homo sapiens	31-38
12643213-2	2003	Human Fc gamma RIIa has 2 codominantly expressed alleles, H131 and R131, which differ at amino acid position 131 in the second extracellular domain (histidine or arginine respectively) and differ substantially in their ability to bind human IgG2.	Histidine	149-158	Fc gamma receptor IIa	Homo sapiens	6-19
12501179-6	2002	The crystal structure suggests that the conformation of the 4-carboxamide of AICAR is poised to increase the nucleophilicity of the C5 amine, while proton abstraction occurs via His(268) concomitant with formyl transfer.	Histidine	178-181	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	Homo sapiens	77-82
12483524-2	2002	Previous reports indicate aphidicolin-induced FRA3B instability occurs over approximately 500 kb which is spanned by the 1.5 Mb fragile histidine triad (FHIT) gene.	Histidine	136-145	fragile histidine triad diadenosine triphosphatase	Homo sapiens	46-51
12483524-2	2002	Previous reports indicate aphidicolin-induced FRA3B instability occurs over approximately 500 kb which is spanned by the 1.5 Mb fragile histidine triad (FHIT) gene.	Histidine	136-145	fragile histidine triad diadenosine triphosphatase	Homo sapiens	153-157
12440857-0	2002	Characterization of novel histidine-tagged Tat-peptide complexes dual-labeled with (99m)Tc-tricarbonyl and fluorescein for scintigraphy and fluorescence microscopy.	Histidine	26-35	tyrosine aminotransferase	Homo sapiens	43-46
12163505-5	2002	Nsp4 adopts the smallest known chymotrypsin-like fold with a canonical catalytic triad of Ser-120, His-39, and Asp-65, as well as a novel alpha/beta C-terminal extension domain that may play a role in mediating protein-protein interactions.	Histidine	99-102	serine protease 57	Homo sapiens	0-4
12215525-9	2002	Histidine limitation in the presence of histidinol induced a twofold increase in the phosphorylation of eIF2alpha and a concomitant reduction in eIF2B activity in perfused livers from wild-type mice, but no changes in livers from Gcn2(-/-) mice.	Histidine	0-9	eukaryotic translation initiation factor 2A	Mus musculus	104-113
12165038-3	2002	The arylsulphotransferase SULT1A1 has been implicated in a decreased activity and thermostability when the wild-type arginine at position 213 of the coding sequence is substituted by a histidine.	Histidine	185-194	sulfotransferase family 1A member 1	Homo sapiens	26-33
12139475-4	2002	The graphical method of Tsou indicates that of six His residues modified in the presence of DEP, only one is essential for ADA activity.	Histidine	51-54	adenosine deaminase	Bos taurus	123-126
12069614-5	2002	Both MS methods detected six CcO subunits with an increased mass of 156 Da after reaction with HNE (subunits II, IV, Vb, VIIa, VIIc, and VIII); this result indicates a single Michael-type reaction site on either a lysine or histidine residue within each subunit.	Histidine	224-233	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	29-32
12069614-8	2002	Reaction of HNE with His-36 of subunit VIII is most consistent with the approximately 50% inhibition of CcO: (1) subunit VIII is modified more than any other subunit by HNE; (2) the time dependence of subunit VIII modification is consistent with the percent inhibition of CcO; (3) His-36 was identified as the HNE-modified amino acid residue within subunit VIII by tandem MS analysis.	Histidine	21-24	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	104-107
12069614-8	2002	Reaction of HNE with His-36 of subunit VIII is most consistent with the approximately 50% inhibition of CcO: (1) subunit VIII is modified more than any other subunit by HNE; (2) the time dependence of subunit VIII modification is consistent with the percent inhibition of CcO; (3) His-36 was identified as the HNE-modified amino acid residue within subunit VIII by tandem MS analysis.	Histidine	21-24	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	272-275
12069614-8	2002	Reaction of HNE with His-36 of subunit VIII is most consistent with the approximately 50% inhibition of CcO: (1) subunit VIII is modified more than any other subunit by HNE; (2) the time dependence of subunit VIII modification is consistent with the percent inhibition of CcO; (3) His-36 was identified as the HNE-modified amino acid residue within subunit VIII by tandem MS analysis.	Histidine	281-284	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	104-107
12004076-4	2002	The hydroxyproline inserts into a gap in the pVHL hydrophobic core, at a site that is a hotspot for tumorigenic mutations, with its 4-hydroxyl group recognized by buried serine and histidine residues.	Histidine	181-190	von Hippel-Lindau tumor suppressor	Homo sapiens	45-49
12115653-1	2002	Histidine decarboxylase (HDC) synthesizes endogenous histamine from histidine in mammals.	Histidine	68-77	histidine decarboxylase	Mus musculus	0-23
12115653-1	2002	Histidine decarboxylase (HDC) synthesizes endogenous histamine from histidine in mammals.	Histidine	68-77	histidine decarboxylase	Mus musculus	25-28
12039800-6	2002	Connexons were solubilized from HeLa-Cx43(His)(6)/Cx45 cells by using Triton X-100 and were applied to a Ni(2+)-NTA column, which binds the His(6) sequence.	Histidine	140-143	gap junction protein alpha 1	Homo sapiens	37-41
11992403-7	2002	Although in 2 of 3 SCC lines 3p loss was correlated with reduced expression of the FHIT (fragile histidine triad) gene, the potential tumor suppressor mapped to 3p14.2 and 2 MCC lines with normal 3p showed aberrant or no FHIT transcripts.	Histidine	97-106	fragile histidine triad diadenosine triphosphatase	Homo sapiens	83-87
11844803-8	2002	EKLF/KLF-1 containing histidine to alanine mutations that disrupt the structure of all three fingers retains appropriate nuclear localization, indicating that neither the tertiary structure of the zinc fingers nor specific DNA binding are necessary for nuclear localization.	Histidine	22-31	Kruppel like factor 1	Homo sapiens	0-4
11844803-8	2002	EKLF/KLF-1 containing histidine to alanine mutations that disrupt the structure of all three fingers retains appropriate nuclear localization, indicating that neither the tertiary structure of the zinc fingers nor specific DNA binding are necessary for nuclear localization.	Histidine	22-31	Kruppel like factor 1	Homo sapiens	5-10
11981042-6	2002	Site-directed mutagenesis of nine nonconserved residues in the C-terminal domain of extracellular loop 2 of the human GnRH receptor showed that a minimum of two mutations (Val(5.24(197))Ala and Trp(5.32(205))His) is needed in this region for agonist activity of antagonist 135-18.	Histidine	208-211	gonadotropin releasing hormone receptor	Homo sapiens	118-131
12013404-0	2002	Effect of repeated L-histidine administration on plasma prolactin and growth hormone levels in rats.	Histidine	19-30	gonadotropin releasing hormone receptor	Rattus norvegicus	70-84
11922755-4	2002	Ligation-independent cloning generated a construct in pET-30 encoding an alpha-TTP fusion protein (pET-30/ttp) containing a six-histidine tag and an S-tag, each cleavable by a separate protease upon expression in Escherichia coli.	Histidine	128-137	SH3 domain binding protein 4	Homo sapiens	106-109
11857562-5	2002	While we did not find ZIC2 mutations in these patients, we did find some evidence of a possible association between a histidine tract polymorphism in ZIC2 and NTDs.	Histidine	118-127	Zic family member 2	Homo sapiens	150-154
11896678-1	2002	FHIT (Fragile Histidine Triad) is a human tumor suppressor gene.	Histidine	14-23	fragile histidine triad diadenosine triphosphatase	Homo sapiens	0-4
11896678-13	2002	Since Cys-39 is not readily accessible in the Fhit molecule, the reaction is most likely facilitated by conformational changes which follow the coordination of Cu(II) by the surface histidines 35, 94, and/or 96.	Histidine	182-192	fragile histidine triad diadenosine triphosphatase	Homo sapiens	46-50
11835994-5	2002	Ac-[D-Tyr(11), His(12), Nle(17)Svg(11-40), named K31440, showed high specific binding to hCRF(2alpha) (K(i) = 1.48 +/- 0.34 nM) and hCRF(2beta) (K(i) = 2.05 +/- 0.61 nM) but not the hCRF(1) receptor (K(i) = 288 +/- 13 nM) and decreased Svg-stimulated cAMP activity in hCRF(2)-expressing cells in a similar fashion as aSvg-30.	Histidine	15-18	corticotropin releasing hormone receptor 1	Homo sapiens	182-189
11741896-6	2002	In GIRK4/GIRK1 heteromers the GIRK4 His-64 and Leu-268 residues showed greater contributions to G beta zeta sensitivity than did the corresponding GIRK1 His-57 and Leu-262 residues.	Histidine	36-39	potassium inwardly rectifying channel subfamily J member 3	Homo sapiens	9-14
11741896-6	2002	In GIRK4/GIRK1 heteromers the GIRK4 His-64 and Leu-268 residues showed greater contributions to G beta zeta sensitivity than did the corresponding GIRK1 His-57 and Leu-262 residues.	Histidine	153-156	potassium inwardly rectifying channel subfamily J member 3	Homo sapiens	9-14
11741896-6	2002	In GIRK4/GIRK1 heteromers the GIRK4 His-64 and Leu-268 residues showed greater contributions to G beta zeta sensitivity than did the corresponding GIRK1 His-57 and Leu-262 residues.	Histidine	153-156	potassium inwardly rectifying channel subfamily J member 3	Homo sapiens	147-152
11939506-0	2002	Hb A2-Monreale [delta146(HC3)His-->Arg], a novel delta chain variant detected in west Sicily.	Histidine	29-32	hemoglobin subunit alpha 2	Homo sapiens	0-5
11784781-9	2002	Replacement of histidines 147 and 151 with tyrosine and lysine residues conferred this neuroprotective Cu phenotype to human APP, APLP2, and Xenopus APP CuBD peptides.	Histidine	15-25	amyloid beta precursor like protein 2	Homo sapiens	130-135
12090476-1	2002	The FHIT gene, a member of the histidine triad family has been identified as a tumor suppressor gene.	Histidine	31-40	fragile histidine triad diadenosine triphosphatase	Homo sapiens	4-8
11912930-5	2002	The active site of MnSOD is dominated by a hydrogen bond network comprising the manganese-bound aqueous ligand, the side chains of four residues (Gln-143, Tyr-34, His-30, and Tyr-166 from an adjacent subunit), as well as other water molecules.	Histidine	163-166	superoxide dismutase 2	Homo sapiens	19-24
11881332-7	2002	In the experiment that follows compared effects of TRH (pyroGlu-His-Pro-NH2) and its metabolite dipeptide cHis-Pro-NH2 (10(-10) M, 10(-5) M).	Histidine	64-67	thyrotropin releasing hormone	Rattus norvegicus	51-54
11739018-3	2001	The activity of the allelic variant or allozyme SULT1A1*1, which possesses an arginine at amino acid position 213 (Arg213) has been shown to be more thermostable than the activity of the SULT1A1*2 allozyme which possesses a histidine at this position (His213) when using p-nitrophenol as the substrate.	Histidine	224-233	sulfotransferase family 1A member 1	Homo sapiens	48-55
11739018-3	2001	The activity of the allelic variant or allozyme SULT1A1*1, which possesses an arginine at amino acid position 213 (Arg213) has been shown to be more thermostable than the activity of the SULT1A1*2 allozyme which possesses a histidine at this position (His213) when using p-nitrophenol as the substrate.	Histidine	224-233	sulfotransferase family 1A member 1	Homo sapiens	187-194
11719446-11	2001	Using purified histidine-tagged P450 1B1, the binding kinetic analysis was performed with TMS, yielding a K(d) of 3 microM.	Histidine	15-24	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	32-40
7919003-2	1994	The homonuclear Nuclear Overhauser and exchange spectroscopy spectrum of the uridine vanadate/RNase A complex exhibits cross peaks between both the C5H and C6H protons of uridine vanadate and the H epsilon 1 proton of His-12 of ribonuclease A.	Histidine	218-221	ribonuclease A family member 1, pancreatic	Homo sapiens	94-101
7919003-3	1994	These cross peaks suggest that the H epsilon 1 proton of His-12 is in the vicinity of the uracil base of uridine vanadate, as observed in the crystallographic structure of the uridine vanadate/RNase A complex.	Histidine	57-60	ribonuclease A family member 1, pancreatic	Homo sapiens	193-200
8003490-3	1994	CDPK isoform AK1 from Arabidopsis was expressed in Escherichia coli as a fusion protein sandwiched between glutathione S-transferase and six consecutive histidines at the N- and C-terminal ends, respectively.	Histidine	153-163	aspartate kinase 1	Arabidopsis thaliana	13-16
8175966-1	1994	The synthetic hexapeptide GH-releasing peptide (GHRP; His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) specifically stimulates GH secretion in humans in vivo and in animals in vitro and in vivo via a still unknown receptor and mechanism.	Histidine	54-57	growth hormone secretagogue receptor	Homo sapiens	26-46
8175966-1	1994	The synthetic hexapeptide GH-releasing peptide (GHRP; His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) specifically stimulates GH secretion in humans in vivo and in animals in vitro and in vivo via a still unknown receptor and mechanism.	Histidine	54-57	growth hormone secretagogue receptor	Homo sapiens	48-52
8135537-0	1994	Chemical modification of human UDP-glucuronosyltransferase UGT1*6 by diethyl pyrocarbonate: possible involvement of a histidine residue in the catalytic process.	Histidine	118-127	UDP glucuronosyltransferase family 1 member A6	Homo sapiens	59-65
8135537-8	1994	The data of the chemical modification of the recombinant enzyme together with that of the pH dependence of the activity strongly suggest the involvement of a histidine residue, highly reactive toward DEPC, which could be the base catalyst of the glucuronidation reaction supported by human UGT1*6.	Histidine	158-167	UDP glucuronosyltransferase family 1 member A6	Homo sapiens	290-296
8307974-4	1994	The three-dimensional crystal structure of the histidine-binding protein complexed with histidine has been determined at 2.5-A resolution by the molecular replacement method using a probe structure the previously solved lysine-liganded structure of the lysine-, arginine-, ornithine-binding protein (LAO), which shares 70% sequence identity with HisJ.	Histidine	47-56	interleukin 4 induced 1	Homo sapiens	253-298
8307974-4	1994	The three-dimensional crystal structure of the histidine-binding protein complexed with histidine has been determined at 2.5-A resolution by the molecular replacement method using a probe structure the previously solved lysine-liganded structure of the lysine-, arginine-, ornithine-binding protein (LAO), which shares 70% sequence identity with HisJ.	Histidine	47-56	interleukin 4 induced 1	Homo sapiens	300-303
8307974-4	1994	The three-dimensional crystal structure of the histidine-binding protein complexed with histidine has been determined at 2.5-A resolution by the molecular replacement method using a probe structure the previously solved lysine-liganded structure of the lysine-, arginine-, ornithine-binding protein (LAO), which shares 70% sequence identity with HisJ.	Histidine	88-97	interleukin 4 induced 1	Homo sapiens	253-298
8307974-4	1994	The three-dimensional crystal structure of the histidine-binding protein complexed with histidine has been determined at 2.5-A resolution by the molecular replacement method using a probe structure the previously solved lysine-liganded structure of the lysine-, arginine-, ornithine-binding protein (LAO), which shares 70% sequence identity with HisJ.	Histidine	88-97	interleukin 4 induced 1	Homo sapiens	300-303
8088501-10	1994	Endogenous (auto)phosphorylation of the ACL histidine as well as its response to vanadate depended on the presence of he substrate (citrate + CoA).	Histidine	44-53	ATP citrate lyase	Rattus norvegicus	40-43
8188630-1	1994	Histidinol dehydrogenase (HDH), a Zn-metalloenzyme, produces His from histidinol through two successive oxidation reactions with NAD+ as a coenzyme.	Histidine	0-3	histidinol dehydrogenase, chloroplastic	Brassica oleracea	26-29
8269928-3	1993	Induction of the regulatory GCN4 mechanism upon histidine starvation, using the anti-metabolite 3-amino-1,2,4-triazole, increased the levels of PDA1 mRNA by approximately 40%.	Histidine	48-57	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	28-32
8376981-2	1993	An antiserum was raised against the synthetic peptide Asp-Ala-Gly-His-Gly-Gln-Ile-Ser-His [neuropeptide gamma-(1-9)-peptide, equivalent to gamma-preprotachykinin-(72-80)-peptide], that showed &lt; 1% reactivity with intact neuropeptide gamma and other tachykinins.	Histidine	86-89	crystallin, gamma E	Rattus norvegicus	104-114
8366040-3	1993	The yeast HIS7 gene represents the first isolated eukaryotic gene encoding the enzymatic activities which catalyze the fifth and sixth step in histidine biosynthesis.	Histidine	143-152	imidazoleglycerol-phosphate synthase	Saccharomyces cerevisiae S288C	10-14
8366040-6	1993	First, the N-terminal and C-terminal segments of the deduced HIS7 amino acid sequence show significant homology to prokaryotic monofunctional glutamine amidotransferases and cyclases, respectively, involved in histidine biosynthesis.	Histidine	210-219	imidazoleglycerol-phosphate synthase	Saccharomyces cerevisiae S288C	61-65
8394123-4	1993	The acid stabilization of insulin"s conformation was attributed to the protonation of histidine at position 5 on the B-chain (HB5) as determined by 1H-NMR of the histidines, selective amino acid alteration, and enthalpies of ionization.	Histidine	162-172	keratin 85	Homo sapiens	126-129
8228729-1	1993	His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 (GHRP-6) is a synthetic peptide unrelated to any known hypothalamic-releasing hormone including growth hormone-releasing hormone (GHRH).	Histidine	0-3	growth hormone releasing hormone	Canis lupus familiaris	162-166
8329391-1	1993	Protein disulfide-isomerase (PDI) contains two thioredoxin-like domains with the active-site sequence: Cys-Gly-His-Cys.	Histidine	111-114	prolyl 4-hydroxylase subunit beta	Bos taurus	0-27
8329391-1	1993	Protein disulfide-isomerase (PDI) contains two thioredoxin-like domains with the active-site sequence: Cys-Gly-His-Cys.	Histidine	111-114	prolyl 4-hydroxylase subunit beta	Bos taurus	29-32
8329391-1	1993	Protein disulfide-isomerase (PDI) contains two thioredoxin-like domains with the active-site sequence: Cys-Gly-His-Cys.	Histidine	111-114	thioredoxin	Bos taurus	47-58
8329391-9	1993	A Pro to His exchange in the active site contributes to half of the change; the other half remains to be identified in the structure of PDI.	Histidine	9-12	prolyl 4-hydroxylase subunit beta	Bos taurus	136-139
8405897-6	1993	The sequence His-Ala-Asp-Gly-Thr5-Phe-Thr-Asn-Asp-Met10-Thr-Ser-Tyr- Leu-Asp15-Ala-Lys-Ala-Ala-Arg20-Asp-Phe-Val-Ser-Trp25- Leu-Ala-Arg-Ser-Asp30- Lys-Ser shows 16 amino acid substitutions compared with the corresponding region of mammalian GLP-1 and 15 substitutions compared with that of salmon GLP.	Histidine	13-16	glucagon like peptide 1 receptor	Homo sapiens	241-246
8411214-3	1993	Imidazole-substituted TRH analogues, which modify the middle amino acid (histidine) of the tripeptide, have more recently been developed but have not been evaluated in models of central nervous system (CNS) trauma.	Histidine	73-82	thyrotropin releasing hormone	Rattus norvegicus	22-25
8433982-0	1993	Histidine residue in the zinc-binding motif of aminopeptidase A is critical for enzymatic activity.	Histidine	0-9	glutamyl aminopeptidase	Mus musculus	47-63
8433982-2	1993	The amino acid sequence deduced from a BP-1 cDNA predicted a type II integral membrane protein with a zinc-binding motif (His-Glu-Xaa-Xaa-His) found in zinc-dependent metallopeptidases, and functional analysis suggested that BP-1 is aminopeptidase A [APA; L-alpha-aspartyl(L-alpha-glutamyl)-peptide hydrolase, EC 3.4.11.7].	Histidine	122-125	glutamyl aminopeptidase	Mus musculus	233-249
8433982-2	1993	The amino acid sequence deduced from a BP-1 cDNA predicted a type II integral membrane protein with a zinc-binding motif (His-Glu-Xaa-Xaa-His) found in zinc-dependent metallopeptidases, and functional analysis suggested that BP-1 is aminopeptidase A [APA; L-alpha-aspartyl(L-alpha-glutamyl)-peptide hydrolase, EC 3.4.11.7].	Histidine	138-141	glutamyl aminopeptidase	Mus musculus	233-249
8419328-4	1993	We have purified the SRS2 protein from Escherichia coli extracts by tagging the SRS2 gene with 6 carboxyl-terminal histidine residues and overexpressing the tagged protein in a pET-3c vector.	Histidine	115-124	DNA helicase SRS2	Saccharomyces cerevisiae S288C	21-25
1397329-3	1992	Recent determination of the three-dimensional structures of pancreatic and microbial lipases has shown that the order of their catalytic residues is Ser, Asp, His, and this fits the order Ser, His of prolyl oligopeptidase.	Histidine	193-196	prolyl endopeptidase	Homo sapiens	200-221
1390778-2	1992	We previously identified five such mutations located in the extracellular domain of the insulin receptor (Asn--&gt;Lys15, His--&gt;Arg209, Phe--&gt;Val382, Lys--&gt;Glu460, and Asn--&gt;Ser462) and studied the effects of these mutations upon posttranslational processing, insulin binding, and tyrosine autophosphorylation.	Histidine	122-125	insulin receptor	Homo sapiens	88-104
1425659-1	1992	L-Histidine decarboxylase (HisDC) is the enzyme catalyzing the formation of histamine from L-histidine.	Histidine	91-102	histidine decarboxylase	Homo sapiens	2-25
1526985-0	1992	Utilization of an active serine 101----cysteine mutant to demonstrate the proximity of the catalytic serine 101 and histidine 237 residues in thioesterase II.	Histidine	116-125	oleoyl-ACP hydrolase	Homo sapiens	142-157
1518828-0	1992	Site-directed mutagenesis of histidine residues involved in Cu(II) binding and reduction by sperm whale myoglobin.	Histidine	29-38	myoglobin	Physeter catodon	104-113
1518828-1	1992	Sperm whale myoglobin (Mb) reduces Cu(II) through a site-specific mechanism involving complexation by one or more surface histidine residues.	Histidine	122-131	myoglobin	Physeter catodon	12-21
1512262-5	1992	In the R-state, His-97 beta 2 is positioned between Thr-38 alpha 1 and Thr-41 alpha 1, whereas in transition to the T-state His 97 beta 2 must "jump" a turn in the alpha 1 C helix to form nonpolar contacts with Thr-41 alpha 1 and Pro-44 alpha 1.	Histidine	16-19	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	23-29
1512262-5	1992	In the R-state, His-97 beta 2 is positioned between Thr-38 alpha 1 and Thr-41 alpha 1, whereas in transition to the T-state His 97 beta 2 must "jump" a turn in the alpha 1 C helix to form nonpolar contacts with Thr-41 alpha 1 and Pro-44 alpha 1.	Histidine	16-19	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	131-137
1512262-5	1992	In the R-state, His-97 beta 2 is positioned between Thr-38 alpha 1 and Thr-41 alpha 1, whereas in transition to the T-state His 97 beta 2 must "jump" a turn in the alpha 1 C helix to form nonpolar contacts with Thr-41 alpha 1 and Pro-44 alpha 1.	Histidine	124-127	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	23-29
1512262-5	1992	In the R-state, His-97 beta 2 is positioned between Thr-38 alpha 1 and Thr-41 alpha 1, whereas in transition to the T-state His 97 beta 2 must "jump" a turn in the alpha 1 C helix to form nonpolar contacts with Thr-41 alpha 1 and Pro-44 alpha 1.	Histidine	124-127	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	131-137
1512262-7	1992	In the R2-state, His-97 beta 2 simply rotates away from threonines 38 alpha 1 and 41 alpha 1, breaking contact with these residues and allowing water access to the center of the alpha 1 beta 2 interface.	Histidine	17-20	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	24-30
1512262-7	1992	In the R2-state, His-97 beta 2 simply rotates away from threonines 38 alpha 1 and 41 alpha 1, breaking contact with these residues and allowing water access to the center of the alpha 1 beta 2 interface.	Histidine	17-20	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	186-192
1495962-0	1992	Coregulation of purine and histidine biosynthesis by the transcriptional activators BAS1 and BAS2.	Histidine	27-36	Bas1p	Saccharomyces cerevisiae S288C	84-88
1495962-2	1992	The transcription factors BAS1 and BAS2/PHO2, which are also regulators of the histidine pathway, participate in the regulation of the purine biosynthetic pathway.	Histidine	79-88	Bas1p	Saccharomyces cerevisiae S288C	26-30
1352085-10	1992	Nevertheless, low levels of endogenous His-Pro DKP and TRH-OH identified in neonatal rat pancreas suggest that TRH or TRH-like peptides may be metabolized in this tissue in intact rats, albeit at low rates.	Histidine	39-42	thyrotropin releasing hormone	Rattus norvegicus	111-114
17075268-1	2006	BACKGROUND: Histamine synthesized by histidine decarboxylase (HDC) from L-histidine is a major chemical mediator in the development of nasal allergy which is characterized by nasal hypersensitivity.	Histidine	72-83	histidine decarboxylase	Rattus norvegicus	62-65
17009983-2	2006	However, no report existed regarding the methylation status of the fragile histidine triad (FHIT) and E-cadherin genes in plasma samples of cervical cancer patients.	Histidine	75-84	fragile histidine triad diadenosine triphosphatase	Homo sapiens	92-96
1304916-0	1992	Characterization of the structure and properties of the His 62--&gt;Ala and Arg 38--&gt;Ala mutants of yeast phosphoglycerate kinase: an investigation of the catalytic and activatory sites by site-directed mutagenesis and NMR.	Histidine	56-59	phosphoglycerate kinase	Saccharomyces cerevisiae S288C	109-132
1314591-1	1992	Analogs of thyrotropin-releasing hormone (Glp-His-Pro-NH2, TRH) have been prepared which contain thioamide moieties in the pyroglutamic acid ring, the carboxyamide proline terminus, and in both positions (dithio).	Histidine	46-49	thyrotropin releasing hormone	Rattus norvegicus	11-40
26626853-2	2006	Molecular dynamics simulations were performed to clarify the most likely binding orientations of Ni(II) Gly-Gly-His and Ni(II) L-Arg-Gly-His upon association with the B-form oligonucleotide d(CGCGAATTCGCG)2.	Histidine	137-140	Rho guanine nucleotide exchange factor 12	Homo sapiens	127-132
1370813-9	1992	Structural comparison of serine proteases (i.e. acyl-amino acid hydrolase or prolyl endopeptidase) with the most conserved domain of THAM identified a stretch of 200 amino acids containing a putative catalytic triad arranged in a novel topological order (Ser-624, Asp-702, and His-734) thereby defining a subfamily of nonclassical serine proteases.	Histidine	277-280	prolyl endopeptidase	Mus musculus	77-97
17064501-1	2006	OBJECTIVE: To investigate the expression of the genes fragile histidine triad (FHIT), Bcl-2, and Bax, biological markers of breast infiltrating ductal carcinoma in this carcinoma and clinicopathological significance thereof.	Histidine	62-71	fragile histidine triad diadenosine triphosphatase	Homo sapiens	79-83
1730807-1	1992	It has been shown that iv GH-releasing peptide (GHRP; His-DTrp-Ala-Trp-DPhe-Lys-NH2) specifically releases GH in man.	Histidine	54-57	growth hormone secretagogue receptor	Homo sapiens	26-46
1730807-1	1992	It has been shown that iv GH-releasing peptide (GHRP; His-DTrp-Ala-Trp-DPhe-Lys-NH2) specifically releases GH in man.	Histidine	54-57	growth hormone secretagogue receptor	Homo sapiens	48-52
16733051-1	2006	Fragile histidine triad (FHIT) gene is involved in the deletions at the 3p14.2 region in various cancers.	Histidine	8-17	fragile histidine triad diadenosine triphosphatase	Homo sapiens	25-29
1325726-1	1992	Thyrotropin Releasing Hormone (TRH; pyroGlu-His-Pro-NH2) is rapidly hydrolyzed at the pyroGlu-His bond by a heterogeneously distributed ectoenzyme and a TRH-degrading serum enzyme.	Histidine	44-47	thyrotropin releasing hormone	Homo sapiens	0-29
1325726-1	1992	Thyrotropin Releasing Hormone (TRH; pyroGlu-His-Pro-NH2) is rapidly hydrolyzed at the pyroGlu-His bond by a heterogeneously distributed ectoenzyme and a TRH-degrading serum enzyme.	Histidine	44-47	thyrotropin releasing hormone	Homo sapiens	31-34
1325726-1	1992	Thyrotropin Releasing Hormone (TRH; pyroGlu-His-Pro-NH2) is rapidly hydrolyzed at the pyroGlu-His bond by a heterogeneously distributed ectoenzyme and a TRH-degrading serum enzyme.	Histidine	44-47	thyrotropin releasing hormone	Homo sapiens	153-156
16518858-5	2006	TAA90K-His bound to fibronectin, collagen IV, laminins-1, -5, and -10 and galectin-3 (Mac-2) but poorly to collagen I and galectin-1.	Histidine	7-10	galectin 3	Homo sapiens	74-84
1310004-1	1992	An analogue of thyrotropin-releasing hormone (TRH, pGlu-His-ProNH2), i.e. pGlu-His-ProNH-(CH2)6-(4-azidosalicylamide) (TRH-ASA), has been synthesized and, in a radioiodinated form (TRH-IASA), characterized and used as a photoaffinity reagent to label the TRH receptor on rat pituitary GH4C1 cells.	Histidine	56-59	thyrotropin releasing hormone	Rattus norvegicus	15-44
16518858-5	2006	TAA90K-His bound to fibronectin, collagen IV, laminins-1, -5, and -10 and galectin-3 (Mac-2) but poorly to collagen I and galectin-1.	Histidine	7-10	galectin 3	Homo sapiens	86-91
1310004-1	1992	An analogue of thyrotropin-releasing hormone (TRH, pGlu-His-ProNH2), i.e. pGlu-His-ProNH-(CH2)6-(4-azidosalicylamide) (TRH-ASA), has been synthesized and, in a radioiodinated form (TRH-IASA), characterized and used as a photoaffinity reagent to label the TRH receptor on rat pituitary GH4C1 cells.	Histidine	56-59	thyrotropin releasing hormone	Rattus norvegicus	46-49
16518858-8	2006	However, at low concentrations, TAA90K-His enhanced galectin-3-mediated HT-29 cell adhesion while at high concentrations, it inhibited cell adhesion.	Histidine	39-42	galectin 3	Homo sapiens	52-62
16885564-1	2006	Loss of fragile histidine triad (Fhit) expression is often associated with human malignancies, and Fhit functions as a tumor suppressor in controlling cell growth and apoptosis, although specific signal pathways are still undefined.	Histidine	16-25	fragile histidine triad diadenosine triphosphatase	Homo sapiens	33-37
1928091-4	1991	This histidine is invariant in all amniotic CA isozymes sequenced to date, as well as the CAs from elasmobranch and algal sources and in a viral CA-related protein.	Histidine	5-14	carbonic anhydrase 8	Homo sapiens	145-163
1915339-7	1991	The His-Phe-Xaa-Asp-Ala sequence (positions 60-64) is similar to the sequence (His-Phe-Asp-Ala) involving the active-site His119 of bovine pancreatic RNase A, and the Pro-Leu-His sequence (positions 124-126) is identical with the sequence involving the active-site His134 of porcine pancreatic DNase I.	Histidine	4-7	deoxyribonuclease 1	Bos taurus	294-301
1915339-7	1991	The His-Phe-Xaa-Asp-Ala sequence (positions 60-64) is similar to the sequence (His-Phe-Asp-Ala) involving the active-site His119 of bovine pancreatic RNase A, and the Pro-Leu-His sequence (positions 124-126) is identical with the sequence involving the active-site His134 of porcine pancreatic DNase I.	Histidine	79-82	deoxyribonuclease 1	Bos taurus	294-301
16790022-0	2006	Histamine, histidine, and growth-phase mediated regulation of the histidine decarboxylase gene in lactic acid bacteria isolated from wine.	Histidine	11-20	histidine decarboxylase	Homo sapiens	66-89
16790022-4	2006	With northern blots and specific activity analysis, we observed that histidine induces the expression of the histidine decarboxylase gene (hdc) and that histamine causes a decrease in the expression of this gene.	Histidine	69-78	histidine decarboxylase	Homo sapiens	109-132
1712588-1	1991	Since the growth hormone-releasing peptide (GHRP), His-D-Trp-Ala-Trp-D-Phe-Lys-NH2, was found to specifically release growth hormone by a complementary but yet not clearly defined action on the pituitary as well as the hypothalamus, in vitro studies have been performed to demonstrate and characterized GHRP binding sites on peripheral membranes of both the rat anterior pituitary and hypothalamus.	Histidine	51-54	ghrelin and obestatin prepropeptide	Rattus norvegicus	10-42
1712588-1	1991	Since the growth hormone-releasing peptide (GHRP), His-D-Trp-Ala-Trp-D-Phe-Lys-NH2, was found to specifically release growth hormone by a complementary but yet not clearly defined action on the pituitary as well as the hypothalamus, in vitro studies have been performed to demonstrate and characterized GHRP binding sites on peripheral membranes of both the rat anterior pituitary and hypothalamus.	Histidine	51-54	ghrelin and obestatin prepropeptide	Rattus norvegicus	44-48
16790022-4	2006	With northern blots and specific activity analysis, we observed that histidine induces the expression of the histidine decarboxylase gene (hdc) and that histamine causes a decrease in the expression of this gene.	Histidine	69-78	histidine decarboxylase	Homo sapiens	139-142
1712588-1	1991	Since the growth hormone-releasing peptide (GHRP), His-D-Trp-Ala-Trp-D-Phe-Lys-NH2, was found to specifically release growth hormone by a complementary but yet not clearly defined action on the pituitary as well as the hypothalamus, in vitro studies have been performed to demonstrate and characterized GHRP binding sites on peripheral membranes of both the rat anterior pituitary and hypothalamus.	Histidine	51-54	ghrelin and obestatin prepropeptide	Rattus norvegicus	303-307
16773697-1	2006	AIM: To detect the loss of heterozygosity (LOH) and microsatellite instabi1ities (MSI) of fragile histidine triad (FHIT) gene in gastric carcinoma and to study their association with the clinical pathological characteristics of gastric carcinoma.	Histidine	98-107	fragile histidine triad diadenosine triphosphatase	Homo sapiens	115-119
1828889-7	1991	Placing the Ca2+ ATP of actin on the ATPase fragment structure suggests Asp-206 (corresponding to His-161 of actin) as a candidate proton acceptor for the ATPase reaction.	Histidine	98-101	actin epsilon 1	Bos taurus	24-29
1828889-7	1991	Placing the Ca2+ ATP of actin on the ATPase fragment structure suggests Asp-206 (corresponding to His-161 of actin) as a candidate proton acceptor for the ATPase reaction.	Histidine	98-101	actin epsilon 1	Bos taurus	109-114
11705857-9	2001	In transport assays with [(3)H]methotrexate and [(3)H]5-formyl tetrahydrofolate, nearly identical uptake rates were measured for the arginine-27- and histidine-27-hRFC proteins expressed in transport-impaired K562 cells.	Histidine	150-159	solute carrier family 19 member 1	Homo sapiens	163-167
11504710-4	2001	Using a fusion protein binding assay, we further identified the histidine-rich acidic repeats of HRC as responsible for the binding of HRC to triadin.	Histidine	64-73	histidine rich calcium binding protein	Homo sapiens	97-100
11504710-4	2001	Using a fusion protein binding assay, we further identified the histidine-rich acidic repeats of HRC as responsible for the binding of HRC to triadin.	Histidine	64-73	histidine rich calcium binding protein	Homo sapiens	135-138
16601116-8	2006	Together, our data explain the pH-regulated activation of furin and how this His-dependent regulatory mechanism is a model for other proteins.	Histidine	77-80	furin, paired basic amino acid cleaving enzyme	Homo sapiens	58-63
11572945-3	2001	Mutagenesis studies with the human enzyme in which the invariant histidines and lysines of the HKD motifs are changed confirm that these highly conserved residues are essential for Tdp1 activity.	Histidine	65-75	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	181-185
2026262-0	1991	ATP-citrate lyase is another enzyme the histidine phosphorylation of which is inhibited by vanadate.	Histidine	40-49	ATP citrate lyase	Rattus norvegicus	0-17
16817893-9	2006	Enzymatic analysis of the purified hexamer His-AtUGD1 revealed that AtUGD1 activity is strongly inhibited by UDP-D-xylose, suggesting that AtUGD1 maintains intracellular levels of UDP-D-glucose in cooperation with AtUXS3 via the inhibition of AtUGD1 by UDP-D-xylose.	Histidine	43-46	UDP-glucuronic acid decarboxylase 3	Arabidopsis thaliana	214-220
1674284-1	1991	The hexapeptide His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 (GHRP-6) and GH-releasing factor (GHRH) produced a rapid release of GH upon perifusion of dispersed rat pituitary cells.	Histidine	16-19	growth hormone releasing hormone	Rattus norvegicus	82-86
1905410-0	1991	The effects of the TRH metabolite cyclo(His-Pro) and its analogs on feeding.	Histidine	40-43	thyrotropin releasing hormone	Rattus norvegicus	19-22
11532518-1	2001	The FHIT (fragile histidine triad) gene, which is located on 3p14.2 and believed to be a tumor suppressor gene, has been reported to lose its expression in several solid tumors and hematologic malignancies, including acute lymphoblastic leukemia (ALL).	Histidine	18-27	fragile histidine triad diadenosine triphosphatase	Homo sapiens	4-8
16731983-1	2006	The Saccharomyces cerevisiae His6 gene codes for the enzyme phosphoribosyl-5-amino-1-phosphoribosyl-4-imidazolecarboxamide isomerase, catalyzing the fourth step in histidine biosynthesis.	Histidine	164-173	1-(5-phosphoribosyl)-5- ((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase HIS6	Saccharomyces cerevisiae S288C	29-33
11525944-1	2001	Five years ago the fragile histidine triad (FHIT) gene including the most common fragile site locus of the human genome, FRA3B, was identified.	Histidine	27-36	fragile histidine triad diadenosine triphosphatase	Homo sapiens	44-48
1905410-1	1991	Cyclo(His-Pro), or cHP, is a putative metabolite of thyrotropin-releasing hormone (TRH), and, like TRH, can inhibit food intake but requires higher doses.	Histidine	6-9	calcineurin-like EF-hand protein 1	Rattus norvegicus	19-22
1905410-1	1991	Cyclo(His-Pro), or cHP, is a putative metabolite of thyrotropin-releasing hormone (TRH), and, like TRH, can inhibit food intake but requires higher doses.	Histidine	6-9	thyrotropin releasing hormone	Rattus norvegicus	52-81
1905410-1	1991	Cyclo(His-Pro), or cHP, is a putative metabolite of thyrotropin-releasing hormone (TRH), and, like TRH, can inhibit food intake but requires higher doses.	Histidine	6-9	thyrotropin releasing hormone	Rattus norvegicus	83-86
1905410-1	1991	Cyclo(His-Pro), or cHP, is a putative metabolite of thyrotropin-releasing hormone (TRH), and, like TRH, can inhibit food intake but requires higher doses.	Histidine	6-9	thyrotropin releasing hormone	Rattus norvegicus	99-102
11525944-1	2001	Five years ago the fragile histidine triad (FHIT) gene including the most common fragile site locus of the human genome, FRA3B, was identified.	Histidine	27-36	fragile histidine triad diadenosine triphosphatase	Homo sapiens	121-126
1825304-5	1991	The entire procedure of kinasing the primer, amplification by PCR, Exo lambda digestion and second step of PCR can be performed in less than 6 h. We have used this approach to generate a number of mutations in the Salmonella typhimurium hisP gene of the histidine transport operon.	Histidine	254-263	exo	Escherichia virus Lambda	67-70
11549352-9	2001	The recombinant histidine tagged MLK7 expressed and purified from insect cells exhibited serine/threonine kinase activity in vitro with myelin basic protein as substrate.	Histidine	16-25	myelin basic protein	Homo sapiens	136-156
17197349-9	2006	Other than histidine 118 residue (amino acid sequence 118: histidine) concerned with NDP kinase activity of nm23-H1, serine 120 (amino acid sequence 120: serine) related activity of histidine-dependent protein phosphotransfer was recently reported to be responsible for its biological suppressive effects.	Histidine	11-20	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	108-127
1812710-10	1991	The positively charged histidine residues (98, 100, and 102) of kappa-casein, which are located prior to the cleavage site, appear to be able to interact with negatively charged residues of chymosin which are quite distant from the active site.	Histidine	23-32	chymosin	Bos taurus	190-198
17197349-9	2006	Other than histidine 118 residue (amino acid sequence 118: histidine) concerned with NDP kinase activity of nm23-H1, serine 120 (amino acid sequence 120: serine) related activity of histidine-dependent protein phosphotransfer was recently reported to be responsible for its biological suppressive effects.	Histidine	59-68	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	108-127
2049934-1	1991	Comparison of amino acid sequences of the alpha-chain fragment of human C4, C4d, has shown C4A- and C4B-specific sequences at residues 1101-1106 in which the aspartic acid-histidine substitution at position 1106 may be related to the amide and ester bond forming properties of these molecules.	Histidine	172-181	complement C4B (Chido blood group)	Homo sapiens	100-103
11561721-0	2001	An essential histidine residue in GTP binding domain of bovine brain glutamate dehydrogenase isoproteins.	Histidine	13-22	glutamate dehydrogenase 1, mitochondrial	Bos taurus	69-92
16637701-6	2006	LC-MS-MS identified four histidine residues (His 36, 81, 88, and 152) of bovine Mb that were readily adducted by HNE, whereas in porcine Mb only two histidine residues (His 24 and 36) were adducted.	Histidine	25-34	myoglobin	Bos taurus	80-82
11561721-1	2001	Greater than 90% of the original activity of the enzymes remained after modification of histidine residues of glutamate dehydrogenase (GDH) isoproteins from bovine brains with diethyl pyrocarbonate (DEPC).	Histidine	88-97	glutamate dehydrogenase 1, mitochondrial	Bos taurus	110-133
11561721-1	2001	Greater than 90% of the original activity of the enzymes remained after modification of histidine residues of glutamate dehydrogenase (GDH) isoproteins from bovine brains with diethyl pyrocarbonate (DEPC).	Histidine	88-97	glutamate dehydrogenase 1, mitochondrial	Bos taurus	135-138
11561721-3	2001	The influence of DEPC modified histidine residue(s) on binding of GTP to GDH isoproteins was investigated by protection studies.	Histidine	31-40	glutamate dehydrogenase 1, mitochondrial	Bos taurus	73-76
11561721-7	2001	These results indicate that the histidine residues may play an important role in the GTP binding on GDH isoproteins.	Histidine	32-41	glutamate dehydrogenase 1, mitochondrial	Bos taurus	100-103
11561721-9	2001	These results indicate that one of the histidine residues is involved in the GTP binding domain of GDH isoproteins.	Histidine	39-48	glutamate dehydrogenase 1, mitochondrial	Bos taurus	99-102
2118103-0	1990	The molecular characterization of PRP6 and PRP9 yeast genes reveals a new cysteine/histidine motif common to several splicing factors.	Histidine	83-92	U4/U6-U5 snRNP complex subunit PRP6	Saccharomyces cerevisiae S288C	34-38
2118103-6	1990	Both PRP6 and PRP9 proteins have cysteine/histidine motifs loosely related to those found in zinc finger proteins.	Histidine	42-51	U4/U6-U5 snRNP complex subunit PRP6	Saccharomyces cerevisiae S288C	5-9
16332725-6	2006	Individuals having ALDH2 Glu/Glu with ADH2 Arg+, ALDH2 Lys+ with ADH2 His/His and ALDH2 Lys+ with ADH2 Arg+ showed ORs of 0.10(0.04-0.21), 0.10 (0.06-0.19) and 1.36 (0.94-1.97), respectively, compared with ALDH2 Glu/Glu with ADH2 His/His.	Histidine	70-73	aldehyde dehydrogenase 2 family member	Homo sapiens	19-24
11493674-3	2001	One of these, designated type II GnRH (GnRH II: pGlu-His-Ser-His-Gly-Trp-Tyr-Pro-Gly-NH2), is conserved from fish to man and is widely distributed in the brain, suggesting important neuromodulatory functions such as regulating K+ channels and stimulating sexual arousal.	Histidine	53-56	gonadotropin releasing hormone 2	Homo sapiens	39-46
11493674-3	2001	One of these, designated type II GnRH (GnRH II: pGlu-His-Ser-His-Gly-Trp-Tyr-Pro-Gly-NH2), is conserved from fish to man and is widely distributed in the brain, suggesting important neuromodulatory functions such as regulating K+ channels and stimulating sexual arousal.	Histidine	61-64	gonadotropin releasing hormone 2	Homo sapiens	39-46
16332725-6	2006	Individuals having ALDH2 Glu/Glu with ADH2 Arg+, ALDH2 Lys+ with ADH2 His/His and ALDH2 Lys+ with ADH2 Arg+ showed ORs of 0.10(0.04-0.21), 0.10 (0.06-0.19) and 1.36 (0.94-1.97), respectively, compared with ALDH2 Glu/Glu with ADH2 His/His.	Histidine	70-73	aldehyde dehydrogenase 2 family member	Homo sapiens	49-54
2122435-3	1990	Bioreversible derivatization of TRH (pGlu-His-Pro-NH2) to protect the tripeptide against rapid enzymatic inactivation in the systemic circulation and to improve the lipophilicity of this highly hydrophilic peptide was performed by N-acylation of the imidazole group of the histidine residue with various chloroformates.	Histidine	273-282	thyrotropin releasing hormone	Homo sapiens	32-35
2122435-4	1990	Whereas TRH was rapidly hydrolyzed at its pGlu-His bond in human plasma by a TRH-specific pyroglutamyl aminopeptidase serum enzyme, the N-alkoxycarbonyl derivatives were resistant to cleavage by the enzyme.	Histidine	47-50	thyrotropin releasing hormone	Homo sapiens	8-11
16332725-6	2006	Individuals having ALDH2 Glu/Glu with ADH2 Arg+, ALDH2 Lys+ with ADH2 His/His and ALDH2 Lys+ with ADH2 Arg+ showed ORs of 0.10(0.04-0.21), 0.10 (0.06-0.19) and 1.36 (0.94-1.97), respectively, compared with ALDH2 Glu/Glu with ADH2 His/His.	Histidine	70-73	aldehyde dehydrogenase 2 family member	Homo sapiens	49-54
16332725-6	2006	Individuals having ALDH2 Glu/Glu with ADH2 Arg+, ALDH2 Lys+ with ADH2 His/His and ALDH2 Lys+ with ADH2 Arg+ showed ORs of 0.10(0.04-0.21), 0.10 (0.06-0.19) and 1.36 (0.94-1.97), respectively, compared with ALDH2 Glu/Glu with ADH2 His/His.	Histidine	70-73	aldehyde dehydrogenase 2 family member	Homo sapiens	49-54
2238092-1	1990	alpha-Fluoromethyl-[S]-histidine (FMH) is a specific and potent inhibitor of histidine decarboxylase, which forms histamine from histidine.	Histidine	23-32	histidine decarboxylase	Homo sapiens	77-100
16332725-6	2006	Individuals having ALDH2 Glu/Glu with ADH2 Arg+, ALDH2 Lys+ with ADH2 His/His and ALDH2 Lys+ with ADH2 Arg+ showed ORs of 0.10(0.04-0.21), 0.10 (0.06-0.19) and 1.36 (0.94-1.97), respectively, compared with ALDH2 Glu/Glu with ADH2 His/His.	Histidine	74-77	aldehyde dehydrogenase 2 family member	Homo sapiens	19-24
16332725-6	2006	Individuals having ALDH2 Glu/Glu with ADH2 Arg+, ALDH2 Lys+ with ADH2 His/His and ALDH2 Lys+ with ADH2 Arg+ showed ORs of 0.10(0.04-0.21), 0.10 (0.06-0.19) and 1.36 (0.94-1.97), respectively, compared with ALDH2 Glu/Glu with ADH2 His/His.	Histidine	74-77	aldehyde dehydrogenase 2 family member	Homo sapiens	49-54
16332725-6	2006	Individuals having ALDH2 Glu/Glu with ADH2 Arg+, ALDH2 Lys+ with ADH2 His/His and ALDH2 Lys+ with ADH2 Arg+ showed ORs of 0.10(0.04-0.21), 0.10 (0.06-0.19) and 1.36 (0.94-1.97), respectively, compared with ALDH2 Glu/Glu with ADH2 His/His.	Histidine	74-77	aldehyde dehydrogenase 2 family member	Homo sapiens	49-54
11382765-0	2001	Conformational change in the vinculin C-terminal depends on a critical histidine residue (His-906).	Histidine	71-80	vinculin	Homo sapiens	29-37
11382765-0	2001	Conformational change in the vinculin C-terminal depends on a critical histidine residue (His-906).	Histidine	90-93	vinculin	Homo sapiens	29-37
2380176-10	1990	Analysis of the results suggests much easier movement of ligand between the heme pocket and the exterior than in sperm whale myoglobin (His(E7].	Histidine	136-139	myoglobin	Physeter catodon	125-134
16332725-6	2006	Individuals having ALDH2 Glu/Glu with ADH2 Arg+, ALDH2 Lys+ with ADH2 His/His and ALDH2 Lys+ with ADH2 Arg+ showed ORs of 0.10(0.04-0.21), 0.10 (0.06-0.19) and 1.36 (0.94-1.97), respectively, compared with ALDH2 Glu/Glu with ADH2 His/His.	Histidine	74-77	aldehyde dehydrogenase 2 family member	Homo sapiens	49-54
16525032-7	2006	DNA sequence analysis revealed a homozygous missense mutation in the hair matrix and cuticle keratin KRTHB5, leading to histidine substitution of a conserved arginine residue (R78H) located in the head domain.	Histidine	120-129	keratin 85	Homo sapiens	101-107
2197413-1	1990	A previously reported renin inhibitor, Boc-Pro-Phe-N(Me)His-Leu psi [CHOHCH2]Val-Ile-Amp (U-71038), was altered by the incorporation of polar, hydrophilic moieties at either end, e.g., tris(hydroxymethyl)aminomethane (THAM) or glucosamine urea groups at the N-terminus, and the THAM amide or aminomethylpyridine N-oxide at the C-terminus.	Histidine	56-59	renin	Rattus norvegicus	22-27
11543851-7	2001	GnRH-I pGlu-His-Trp-Ser-Try-Gly-Leu-Arg-Pro-Gly-NH2 and 2.	Histidine	12-15	gonadotropin releasing hormone 2	Homo sapiens	0-4
16475789-2	2006	Myc-tagged BAFF starting at residue Gln136 was previously reported to crystallize as trimers at pH 4.5, whereas a histidine-tagged construct of BAFF, starting at residue Ala134, formed a virus-like cluster containing 60 monomers when crystallized at pH 9.0.	Histidine	114-123	TNF superfamily member 13b	Homo sapiens	144-148
11543851-8	2001	GnRH-II pGlu-His-Trp-Ser-His-Gly-Trp-Tyr-Pro-Gly-NH2.	Histidine	13-16	gonadotropin releasing hormone 2	Homo sapiens	0-7
11543851-8	2001	GnRH-II pGlu-His-Trp-Ser-His-Gly-Trp-Tyr-Pro-Gly-NH2.	Histidine	25-28	gonadotropin releasing hormone 2	Homo sapiens	0-7
2118634-1	1990	The kinetics and mechanism of degradation of the tripeptide TRH (pGlu-His-Pro-NH2) and its various primary and secondary degradation products (TRH-OH, His-Pro-NH2, and His-Pro) have been determined in human plasma at 37 degrees C. The rates of degradation of both TRH and TRH-OH (pGlu-His-Pro) showed mixed zero-order and first-order kinetics.	Histidine	151-154	thyrotropin releasing hormone	Homo sapiens	60-63
2118634-1	1990	The kinetics and mechanism of degradation of the tripeptide TRH (pGlu-His-Pro-NH2) and its various primary and secondary degradation products (TRH-OH, His-Pro-NH2, and His-Pro) have been determined in human plasma at 37 degrees C. The rates of degradation of both TRH and TRH-OH (pGlu-His-Pro) showed mixed zero-order and first-order kinetics.	Histidine	151-154	thyrotropin releasing hormone	Homo sapiens	60-63
16282320-4	2006	Yeast expression experiments demonstrated that HMA1 is involved in copper homeostasis and that deletion of its N-terminal His-domain partially affects the metal transport.	Histidine	122-125	heavy metal atpase 1	Arabidopsis thaliana	47-51
2118634-1	1990	The kinetics and mechanism of degradation of the tripeptide TRH (pGlu-His-Pro-NH2) and its various primary and secondary degradation products (TRH-OH, His-Pro-NH2, and His-Pro) have been determined in human plasma at 37 degrees C. The rates of degradation of both TRH and TRH-OH (pGlu-His-Pro) showed mixed zero-order and first-order kinetics.	Histidine	151-154	thyrotropin releasing hormone	Homo sapiens	60-63
2118634-3	1990	The initial step in the plasma-catalyzed degradation of TRH is due to hydrolysis of the pGlu-His bond by the TRH-specific pyroglutamyl aminopeptidase serum enzyme, resulting in the exclusive formation of histidyl-proline amide (His-Pro-NH2).	Histidine	93-96	thyrotropin releasing hormone	Homo sapiens	56-59
2118634-3	1990	The initial step in the plasma-catalyzed degradation of TRH is due to hydrolysis of the pGlu-His bond by the TRH-specific pyroglutamyl aminopeptidase serum enzyme, resulting in the exclusive formation of histidyl-proline amide (His-Pro-NH2).	Histidine	93-96	thyrotropin releasing hormone	Homo sapiens	109-112
2113484-2	1990	TRH-extended peptides have been detected in the rat olfactory lobe: these peptides accounted for approximately 11% of the total TRH immunoreactivity present in the tissue and contained the sequence pGlu-His-Pro-Gly-Arg exclusively at their N-termini.	Histidine	203-206	thyrotropin releasing hormone	Rattus norvegicus	0-3
11478947-1	2001	Histidine decarboxylase (HDC) synthesizes histamine from histidine in mammals.	Histidine	57-66	histidine decarboxylase	Mus musculus	0-23
11478947-1	2001	Histidine decarboxylase (HDC) synthesizes histamine from histidine in mammals.	Histidine	57-66	histidine decarboxylase	Mus musculus	25-28
11461085-1	2001	The FHIT (fragile histidine triad) gene on chromosome 3p14.2 is a candidate tumour suppressor gene.	Histidine	18-27	fragile histidine triad diadenosine triphosphatase	Homo sapiens	4-8
16391790-4	2006	The recombinant TK1-2 prepared through E. coli expression, His-tag affinity chromatography and in vitro refolding was injected intraperitoneally once daily into nude mice 7 days after subcutaneous implantation with PC14 lung cancer cells (n=10).	Histidine	59-62	thymidine kinase 2, mitochondrial	Mus musculus	16-21
34633480-0	2021	Partial structure, dampened mobility, and modest impact of a His tag in the SARS-CoV-2 Nsp2 C-terminal region.	Histidine	61-64	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	87-91
34633480-7	2021	The 13Cbeta and backbone 13CO, 1HN, 13Calpha, and 15N nuclei of Nsp2"s 45-residue CtR were assigned and used to characterize its structure and dynamics in three contexts; namely: (1) retaining an N-terminal His tag, (2) without the His tag and with an adventitious internal cleavage, and (3) lacking both the His tag and the internal cleavage.	Histidine	309-312	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	64-68
16513840-1	2006	The fragile histidine triad (FHIT) gene located at the 3p14.2 locus plays an important role in the pathogenesis of lung cancer.	Histidine	12-21	fragile histidine triad diadenosine triphosphatase	Homo sapiens	29-33
34901149-1	2021	The fragile histidine triad (FHIT) protein is a member of the large and ubiquitous histidine triad (HIT) family of proteins.	Histidine	12-21	fragile histidine triad diadenosine triphosphatase	Homo sapiens	29-33
34901149-1	2021	The fragile histidine triad (FHIT) protein is a member of the large and ubiquitous histidine triad (HIT) family of proteins.	Histidine	83-92	fragile histidine triad diadenosine triphosphatase	Homo sapiens	29-33
11358956-4	2001	Consistent with a pore-blocking mechanism, inhibition was dependent on voltage, potassium concentration, and a histidine in the first P domain (P1H).	Histidine	111-120	minichromosome maintenance complex component 3	Homo sapiens	144-147
16429145-0	2006	Histidine button engineered into cardiac troponin I protects the ischemic and failing heart.	Histidine	0-9	troponin I, cardiac 3	Mus musculus	33-51
11423433-3	2001	Previous studies revealed that Cu(2+) binds to the unstructured N-terminal PrP(C) segment (residues 23-120) through conserved histidine residues.	Histidine	126-135	prion protein	Mus musculus	75-81
34880885-5	2021	In this study, we isolated one large dumbbell-shaped and asymmetric division chloroplast Arabidopsis mutant Chloroplast Division Mutant 75 (cdm75) that contains a missense mutation, changing the arginine at residue 49 to a histidine (R49H), and this mutant point is located in the N-terminal Conserved Terrestrial Sequence (NCTS) motif of AtMinD1, which is only typically found in terrestrial plants.	Histidine	223-232	septum site-determining protein (MIND)	Arabidopsis thaliana	339-346
16407156-3	2006	Here, we analyzed the function of three residues in the ar/R constriction (Phe-56, His-180, and Arg-195) in rat AQP1.	Histidine	83-86	aquaporin 1	Rattus norvegicus	112-116
11702710-4	2001	The recombinant 6 x His-GDF-8 fusion protein expressed in the Top10 cells was purified by Ni(+)-Affinity Chromatography for future study.	Histidine	20-23	myostatin	Gallus gallus	24-29
16378185-2	2006	Two tumor suppressor genes, the fragile histidine triad (FHIT) gene and the WW domain-containing oxidoreductase (WWOX), map to the common fragile sites, FRA3B and FRA16D, respectively.	Histidine	40-49	fragile histidine triad diadenosine triphosphatase	Homo sapiens	57-61
16378185-2	2006	Two tumor suppressor genes, the fragile histidine triad (FHIT) gene and the WW domain-containing oxidoreductase (WWOX), map to the common fragile sites, FRA3B and FRA16D, respectively.	Histidine	40-49	fragile histidine triad diadenosine triphosphatase	Homo sapiens	153-158
34828026-7	2021	Furthermore, the mRNA expression of PCK1 was significantly elevated (p < 0.05) by the addition of 1.2 mM His at 3, 6, 12, and 24 h of incubation.	Histidine	105-108	phosphoenolpyruvate carboxykinase 1	Bos taurus	36-40
16080185-4	2005	Digestion of the hexahistidine tag of MBP-His(6) by Factor Xa and HT15-MBP by DAPase-1 was successful.	Histidine	42-45	myelin basic protein	Homo sapiens	38-41
11389064-0	2001	Abnormal fragile histidine triad (FHIT) expression in advanced cervical carcinoma: a poor prognostic factor.	Histidine	17-26	fragile histidine triad diadenosine triphosphatase	Homo sapiens	34-38
16080185-5	2005	The time taken to complete the conversion of MBP-His(6) to MBP was 16 h, as judged by SDS-PAGE and Western blots against anti-His antibody.	Histidine	49-52	myelin basic protein	Homo sapiens	45-48
11145957-8	2001	At pH 5.5, the affinity of the wild-type peptide for heparin/heparan sulfate was increased, implying a role for histidine residues at positions 6 and 28 of pro-IAPP.	Histidine	112-121	islet amyloid polypeptide	Homo sapiens	160-164
34230963-10	2021	Hi-C data reveal that the physical interactions between Plp1-E1/2 and PLP1 are among the strongest in OLs and specific to OLs.	Histidine	0-2	proteolipid protein 1	Rattus norvegicus	56-60
34230963-10	2021	Hi-C data reveal that the physical interactions between Plp1-E1/2 and PLP1 are among the strongest in OLs and specific to OLs.	Histidine	0-2	proteolipid protein 1	Rattus norvegicus	70-74
16080185-5	2005	The time taken to complete the conversion of MBP-His(6) to MBP was 16 h, as judged by SDS-PAGE and Western blots against anti-His antibody.	Histidine	49-52	myelin basic protein	Homo sapiens	59-62
16080185-5	2005	The time taken to complete the conversion of MBP-His(6) to MBP was 16 h, as judged by SDS-PAGE and Western blots against anti-His antibody.	Histidine	126-129	myelin basic protein	Homo sapiens	45-48
16080185-5	2005	The time taken to complete the conversion of MBP-His(6) to MBP was 16 h, as judged by SDS-PAGE and Western blots against anti-His antibody.	Histidine	126-129	myelin basic protein	Homo sapiens	59-62
11339812-2	2001	Utilizing an efficient heterologous expression system that produces a histidine-tagged form of the hydrophilic, diaphorase domain of the enzyme, site-directed mutagenesis has been used to generate cb5r mutants with substitutions at position 91 in the primary sequence.	Histidine	70-79	dihydrolipoamide dehydrogenase	Homo sapiens	112-122
16080185-11	2005	The detagged MBP proteins were isolated from the digestion mixtures using a simple subtractive IMAC column procedure with the detagged protein appearing in the flowthrough and washing fractions while residual dipeptides and DAPase-I (which was engineered to exhibit a poly-His tail) were adsorbed to the column.	Histidine	273-276	myelin basic protein	Homo sapiens	13-16
16271884-4	2005	Mutation of Tf histidine residues predicted to interact with the W641/F760 patch eliminates TfR-dependent acceleration of iron release.	Histidine	15-24	transferrin receptor	Homo sapiens	92-95
11382545-0	2001	Dietary supplements of mixtures of indispensable amino acids lacking threonine, phenylalanine or histidine increase the activity of hepatic threonine dehydrogenase, phenylalanine hydroxylase or histidase, respectively, and prevent growth depressions in chicks caused by dietary excesses of threonine, phenylalanine, or histidine* Experiments were carried out to determine whether the addition of a mixture of indispensable amino acids (IAA) lacking in threonine, phenylalanine or histidine, respectively, to a nutritionally complete diet would increase the hepatic activities of the rate-limiting enzymes for catabolism of threonine, phenylalanine or histidine and prevent the adverse effects of the amino acid on growth when the dietary level of the amino acid is excessive.	Histidine	97-106	phenylalanine hydroxylase	Homo sapiens	165-190
34734351-2	2021	Histidine decarboxylase (HDC), the unique enzyme that converts L-histidine to histamine, is highly expressed in CD11b+ immature myeloid cells.	Histidine	63-74	histidine decarboxylase	Homo sapiens	0-23
34734351-2	2021	Histidine decarboxylase (HDC), the unique enzyme that converts L-histidine to histamine, is highly expressed in CD11b+ immature myeloid cells.	Histidine	63-74	histidine decarboxylase	Homo sapiens	25-28
34255889-3	2021	We identified SNPs in FCGR2A (131 histidine (H) or arginine (R); rs1801274) and reviewed the infectious complication-free survival after ICU discharge.	Histidine	34-43	Fc gamma receptor IIa	Homo sapiens	22-28
11306145-1	2001	Histamine, a principal mediator in various physiological and pathological cell functions is synthesized from L-histidine exclusively by histidine decarboxylase, an enzyme, which is expressed in many tissues of mammalian organism.	Histidine	109-120	histidine decarboxylase	Homo sapiens	136-159
16396320-2	2005	It was shown that interrelation of genotypes Arg/Arg, Arg/His and His/His in LMP2 gene polymorphism is 52, 40.5 and 7.5 % correspondingly (in control group 53.8, 38.7, 7.5 %; P &gt; 0.05 by chi2-test).	Histidine	66-69	proteasome 20S subunit beta 9	Homo sapiens	77-81
34453614-6	2021	We further show that the extra electron in the (2Fe-2S)+ clusters of one of the NEET proteins (mNT) is localized on the His-bound iron ion, consistently with our previous spectroscopic studies.	Histidine	120-123	max binding protein	Mus musculus	95-98
16396320-2	2005	It was shown that interrelation of genotypes Arg/Arg, Arg/His and His/His in LMP2 gene polymorphism is 52, 40.5 and 7.5 % correspondingly (in control group 53.8, 38.7, 7.5 %; P &gt; 0.05 by chi2-test).	Histidine	66-69	proteasome 20S subunit beta 9	Homo sapiens	77-81
16102717-3	2005	It also allowed us to accurately determine the kinetic rate constants for the interaction between His-CypA and CsA.	Histidine	98-101	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	111-114
34231327-4	2021	Due to the unique properties and significant role of histidine in protein sequences, here for the first time, the tautomeric effect of histidine at the early stages of amylin misfolding was investigated via molecular dynamics simulations.	Histidine	53-62	islet amyloid polypeptide	Homo sapiens	168-174
34231327-4	2021	Due to the unique properties and significant role of histidine in protein sequences, here for the first time, the tautomeric effect of histidine at the early stages of amylin misfolding was investigated via molecular dynamics simulations.	Histidine	135-144	islet amyloid polypeptide	Homo sapiens	168-174
11261897-1	2001	The purpose of this investigation was to study the effectiveness of two nickel-binding amino acids, histidine (His) and cysteine (Cys), to prevent the inhibitory action of Ni2+ on testosterone (T) production by mouse primary Leydig cell culture.	Histidine	100-109	vacuole membrane protein 1	Mus musculus	172-175
11261897-1	2001	The purpose of this investigation was to study the effectiveness of two nickel-binding amino acids, histidine (His) and cysteine (Cys), to prevent the inhibitory action of Ni2+ on testosterone (T) production by mouse primary Leydig cell culture.	Histidine	111-114	vacuole membrane protein 1	Mus musculus	172-175
16198348-0	2005	Identification of conserved histidines and glutamic acid as key residues for isomerohydrolase activity of RPE65, an enzyme of the visual cycle in the retinal pigment epithelium.	Histidine	28-38	retinoid isomerohydrolase RPE65	Homo sapiens	106-111
11261897-12	2001	Our results show that both His and Cys are able to moderate the effects of Ni2+ on Leydig cell T production, depending on the concentration of this metal ion, as well as on amino acid.	Histidine	27-30	vacuole membrane protein 1	Mus musculus	75-78
11261897-13	2001	However, at higher Ni2+ concentrations the complete protection by His or Cys is only temporary.	Histidine	66-69	vacuole membrane protein 1	Mus musculus	19-22
34476115-5	2021	Ultimately, MVP  emerged as a primitive means to promote His-Purkinje activation, and it is not a coincidence that its roots can be traced back to first-in-man permanent His-bundle pacing.	Histidine	57-60	major vault protein	Homo sapiens	12-15
34476115-5	2021	Ultimately, MVP  emerged as a primitive means to promote His-Purkinje activation, and it is not a coincidence that its roots can be traced back to first-in-man permanent His-bundle pacing.	Histidine	170-173	major vault protein	Homo sapiens	12-15
11301476-3	2001	The region of 3p14.2-pter encompasses a region of frequent loss and contains at least three tumor-suppressor genes: fragile histidine triad (FHIT), transforming growth factor-beta receptor II (T beta R-II), and Von Hippel-Lindau.	Histidine	124-133	fragile histidine triad diadenosine triphosphatase	Homo sapiens	141-145
16198348-2	2005	Here, we demonstrated that mutation of any one of the absolutely conserved four histidine and one glutamic acid residues to alanine in RPE65 abolished its isomerohydrolase activity.	Histidine	80-89	retinoid isomerohydrolase RPE65	Homo sapiens	135-140
16204026-1	2005	Fragile histidine triad (FHIT) gene deletion or promoter methylation and reduced Fhit protein expression occur in approximately 70% of human epithelial tumors and, in some cancers, are clearly associated with tumor progression.	Histidine	8-17	fragile histidine triad diadenosine triphosphatase	Homo sapiens	25-29
11219777-2	2001	A G---&gt;A transition at codon 213 (CGC/Arg to CAC/His) of the SULT1A1 gene was reported recently, and individuals homozygous for the His allele have a substantially lower activity of this enzyme than those with other genotypes.	Histidine	52-55	sulfotransferase family 1A member 1	Homo sapiens	64-71
11230563-3	2001	By employing the well-known His--&gt;Asp phosphorelay systems in both the fission yeast and Escherichia coli, evidence is presented showing that the AHK4 His-kinase has an ability to serve as a cytokinin-responsive environmental sensor.	Histidine	28-31	CHASE domain containing histidine kinase protein	Arabidopsis thaliana	149-153
34350692-3	2022	Structural analyses of 1-Pro-His suggested that the peptide backbone of (SeH,SeH) is rigidly bent to form a gamma-turn, possibly including an NH   Se hydrogen bond between the imidazole ring of His and selenol group, thus stabilizing the (SeH,SeH) form thermodynamically, and dramatically enhancing the catalytic activity.	Histidine	194-197	epoxide hydrolase 2	Homo sapiens	73-76
34350692-3	2022	Structural analyses of 1-Pro-His suggested that the peptide backbone of (SeH,SeH) is rigidly bent to form a gamma-turn, possibly including an NH   Se hydrogen bond between the imidazole ring of His and selenol group, thus stabilizing the (SeH,SeH) form thermodynamically, and dramatically enhancing the catalytic activity.	Histidine	194-197	epoxide hydrolase 2	Homo sapiens	77-80
34350692-3	2022	Structural analyses of 1-Pro-His suggested that the peptide backbone of (SeH,SeH) is rigidly bent to form a gamma-turn, possibly including an NH   Se hydrogen bond between the imidazole ring of His and selenol group, thus stabilizing the (SeH,SeH) form thermodynamically, and dramatically enhancing the catalytic activity.	Histidine	194-197	epoxide hydrolase 2	Homo sapiens	239-242
34350692-3	2022	Structural analyses of 1-Pro-His suggested that the peptide backbone of (SeH,SeH) is rigidly bent to form a gamma-turn, possibly including an NH   Se hydrogen bond between the imidazole ring of His and selenol group, thus stabilizing the (SeH,SeH) form thermodynamically, and dramatically enhancing the catalytic activity.	Histidine	194-197	epoxide hydrolase 2	Homo sapiens	243-246
16533025-6	2005	With trypsin inhibitor, this loss of activity is associated with the selective oxidation of Trp, Tyr, and His residues, which results in protein unfolding and the disruption of complex formation with active trypsin.	Histidine	106-109	cysteine rich secretory protein LCCL domain containing 2	Homo sapiens	5-22
34126150-0	2021	Synthesis of magnetic nanoparticles functionalized with histidine and nickel to immobilize His-tagged enzymes using beta-galactosidase as a model.	Histidine	56-65	galactosidase beta 1	Homo sapiens	116-134
34126150-0	2021	Synthesis of magnetic nanoparticles functionalized with histidine and nickel to immobilize His-tagged enzymes using beta-galactosidase as a model.	Histidine	91-94	galactosidase beta 1	Homo sapiens	116-134
34126150-1	2021	The aim of this study was to synthesize iron magnetic nanoparticles functionalized with histidine and nickel (Fe3O4-His-Ni) to be used as support materials for oriented immobilization of His-tagged recombinant enzymes of high molecular weight, using beta-galactosidase as a model.	Histidine	88-97	galactosidase beta 1	Homo sapiens	250-268
34126150-9	2021	The iron nanoparticles functionalized with histidine and nickel were efficient in the oriented immobilization of the recombinant beta-galactosidase, showing its potential application in other high-molecular-weight enzymes.	Histidine	43-52	galactosidase beta 1	Homo sapiens	129-147
11246544-0	2001	Factor VIII Arg2304 --&gt; His binds to phosphatidylserine and is a functional cofactor in the factor X-ase complex.	Histidine	27-30	cytochrome c oxidase subunit 8A	Homo sapiens	7-11
11231005-0	2001	Two histidine residues are essential for catalysis by lecithin retinol acyl transferase.	Histidine	4-13	lecithin retinol acyltransferase	Homo sapiens	54-87
16164414-8	2005	The same results were observed with C-terminally His-tagged PFK2.	Histidine	49-52	6-phosphofructokinase subunit beta	Saccharomyces cerevisiae S288C	60-64
11115560-2	2001	The majority (4/5) of the patients had LOH at or close to the fragile histidine triad (FHIT) gene (3p14.2; D3S1300), which is a candidate tumor suppressor gene for many cancer types.	Histidine	70-79	fragile histidine triad diadenosine triphosphatase	Homo sapiens	87-91
34264642-5	2021	Incubation of IAPP with exogenous HNE accelerated its self-assembly into beta-sheet fibrils and led to the formation of a Michael adduct on the His-18 side chain.	Histidine	144-147	islet amyloid polypeptide	Homo sapiens	14-18
34264642-7	2021	IAPP lipidated at His-18 showed a hastened random coil-to-beta-sheet conformational conversion into fibrillar assemblies with a distinct morphology, a low level of binding to thioflavin T, and a high surface hydrophobicity.	Histidine	18-21	islet amyloid polypeptide	Homo sapiens	0-4
15976002-4	2005	Histidine (His)-tagged soluble RAP (amino acids 39 to 356) lacking the amino-terminal signal peptide and the carboxy-terminal endoplasmic reticulum retention signal was prepared by bacterial expression (designated His-sRAP).	Histidine	0-9	low density lipoprotein receptor-related protein associated protein 1	Mus musculus	31-34
34073441-9	2021	hCST3 proteins were efficiently purified from muscle and egg white of transgenic chickens using a His-tag purification system.	Histidine	98-101	cystatin C	Homo sapiens	0-5
11199158-8	2001	In addition, normal and neoplastic cells expressed fragile histidine triad (FHIT) protein; surprisingly, some pagetoid cells did not.	Histidine	59-68	fragile histidine triad diadenosine triphosphatase	Bos taurus	76-80
15976002-4	2005	Histidine (His)-tagged soluble RAP (amino acids 39 to 356) lacking the amino-terminal signal peptide and the carboxy-terminal endoplasmic reticulum retention signal was prepared by bacterial expression (designated His-sRAP).	Histidine	0-3	low density lipoprotein receptor-related protein associated protein 1	Mus musculus	31-34
15799721-3	2005	Previous studies have demonstrated that replacement of histidine in TRH (thyrotropin-releasing hormone) with asparagine produces a competitive PPII inhibitor (Ki 17.5 microM).	Histidine	55-64	thyrotropin releasing hormone	Rattus norvegicus	68-71
11120754-3	2000	Here, we demonstrate that PV IgGs eluted from rDsg1-Ig-His and rDsg3-Ig-His show similar antigenic profiles, including the 38-, 43-, 115-, and 190-kDa keratinocyte proteins and a non-Dsg 3 130-kDa polypeptide present in keratinocytes from Dsg 3 knockout mouse.	Histidine	72-75	desmoglein 3	Rattus norvegicus	63-68
34490059-5	2021	The calculated pH effects in pre-fusion spike trimers are modulated mainly by aspartic acid residues, rather than the more familiar histidine role at mild acidic pH.	Histidine	132-141	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	40-45
11093802-0	2000	Importance of histidine residues for the function of the human liver UDP-glucuronosyltransferase UGT1A6: evidence for the catalytic role of histidine 370.	Histidine	14-23	UDP glucuronosyltransferase family 1 member A6	Homo sapiens	97-103
15799721-3	2005	Previous studies have demonstrated that replacement of histidine in TRH (thyrotropin-releasing hormone) with asparagine produces a competitive PPII inhibitor (Ki 17.5 microM).	Histidine	55-64	thyrotropin releasing hormone	Rattus norvegicus	73-102
11093802-0	2000	Importance of histidine residues for the function of the human liver UDP-glucuronosyltransferase UGT1A6: evidence for the catalytic role of histidine 370.	Histidine	140-149	UDP glucuronosyltransferase family 1 member A6	Homo sapiens	97-103
35429681-1	2022	Histamine is synthesised from l-histidine through the catalysis of histidine decarboxylase (HDC).	Histidine	30-41	histidine decarboxylase	Mus musculus	67-90
35429681-1	2022	Histamine is synthesised from l-histidine through the catalysis of histidine decarboxylase (HDC).	Histidine	30-41	histidine decarboxylase	Mus musculus	92-95
15908697-7	2005	Molecular modeling of the Rad51-G103E mutant protein shows that the negatively charged glutamate residue lies on the surface of the N-terminal domain facing a positively charged patch composed of Arg-260, His-302, and Lys-305 on the ATPase core domain.	Histidine	205-208	recombinase RAD51	Saccharomyces cerevisiae S288C	26-31
35429681-11	2022	This beneficial effect of histidine on memory was cancelled by intracerebroventricular injection of the HDC inhibitor alpha-fluoromethylhistidine.	Histidine	26-35	histidine decarboxylase	Mus musculus	104-107
11053353-3	2000	We performed site-directed mutagenesis to generate a series of NH(2)-terminal histidine (His)-tagged mutants of human SM22 in Escherichia coli and used these to analyze the functional importance of potential actin binding domains.	Histidine	78-87	transgelin	Homo sapiens	118-122
11053353-3	2000	We performed site-directed mutagenesis to generate a series of NH(2)-terminal histidine (His)-tagged mutants of human SM22 in Escherichia coli and used these to analyze the functional importance of potential actin binding domains.	Histidine	89-92	transgelin	Homo sapiens	118-122
17160139-12	2005	All the His-containing analogs behave like TRH in terms of the above properties.	Histidine	8-11	thyrotropin releasing hormone	Homo sapiens	43-46
11095181-0	2000	Divergent solid-phase synthesis and candidacidal activity of MUC7 D1, a 51-residue histidine-rich N-terminal domain of human salivary mucin MUC7.	Histidine	83-92	mucin 7, secreted	Homo sapiens	61-65
11095181-0	2000	Divergent solid-phase synthesis and candidacidal activity of MUC7 D1, a 51-residue histidine-rich N-terminal domain of human salivary mucin MUC7.	Histidine	83-92	mucin 7, secreted	Homo sapiens	140-144
35629830-5	2022	At present, existing pH-sensitive materials are mainly based on polyaniline (PANI), hydrogen ionophores (HIs) and metal oxides (MOx).	Histidine	105-108	phenylalanine hydroxylase	Homo sapiens	21-23
15769590-2	2005	A histidine-containing phosphotransfer protein, YPD1, represents a bifurcation point between the SLN1-YPD1-SSK1 pathway responsible for osmotic stress responses and the SLN1-YPD1-SKN7 pathway involved in cell wall biosynthesis and cell cycle control.	Histidine	2-11	Ypd1p	Saccharomyces cerevisiae S288C	48-52
35529437-9	2022	Histidine can be decarboxylated to histamine by histidine decarboxylase.	Histidine	0-9	histidine decarboxylase	Homo sapiens	48-71
11022003-2	2000	Previously we reported that the N-terminal Tyr residue of nsP4 of Sindbis virus, the type species of the genus Alphavirus, can be substituted with Phe, Trp, or His without altering the wild-type phenotype in cultured cells but that other substitutions tested, except for Met, were lethal or quasilethal.	Histidine	160-163	serine protease 57	Homo sapiens	58-62
15769590-2	2005	A histidine-containing phosphotransfer protein, YPD1, represents a bifurcation point between the SLN1-YPD1-SSK1 pathway responsible for osmotic stress responses and the SLN1-YPD1-SKN7 pathway involved in cell wall biosynthesis and cell cycle control.	Histidine	2-11	histidine kinase	Saccharomyces cerevisiae S288C	97-101
11027581-5	2000	Since the His and Asp residues are both responsible for binding Zn which would serve to maintain the folded structure, the structural integrity supported by the coordinated Zn ion would be essential for CCS function.	Histidine	10-13	copper chaperone for superoxide dismutase	Homo sapiens	203-206
10998365-7	2000	Both PDT-induced caspase-3 activation and PAK2 cleavage/activation can be inhibited by the singlet oxygen scavengers, L-histidine and alpha-tocopherol, but not the hydroxyl radical scavenger, mannitol, demonstrating that singlet oxygen is an immediate early-apoptotic signal generated by PDT.	Histidine	118-129	p21 (RAC1) activated kinase 2	Homo sapiens	42-46
10962030-6	2000	The receptors for GHRH antagonists on CAKI-1 tumors are distinct from binding sites detected with (125)I-VIP (K(d) = 0.89 +/- 0.14 nM; B(max) = 183.5 +/- 2.6 fmol/mg of protein) and also have different characteristics from GHRH receptors on rat pituitary as documented by the insignificant binding of [His(1),(125)I-Tyr(10), Nle(27)]hGHRH(1-32)NH(2).	Histidine	302-305	growth hormone releasing hormone	Rattus norvegicus	18-22
11007995-9	2000	Interestingly, the human fragile histidine triad (Fhit) tumor suppressor protein appears to be a typical Np(3)N" hydrolase.	Histidine	33-42	fragile histidine triad diadenosine triphosphatase	Homo sapiens	50-54
11007995-16	2000	In contrast, the Schizosaccharomyces pombe Ap(4)A/Ap(3)A hydrolase, the human Fhit protein, and the yeast Np(n)N" phosphorylases belong to a superfamily GAFH, which includes the histidine triad proteins.	Histidine	178-187	fragile histidine triad diadenosine triphosphatase	Homo sapiens	78-82
10889019-4	2000	61(98))Glu mutation markedly decreased the affinity for a series of GnRH analogues containing the native His(2) residue.	Histidine	105-108	gonadotropin releasing hormone 1	Homo sapiens	68-72
10896716-0	2000	Inhibition of the K+ channel kv1.4 by acidosis: protonation of an extracellular histidine slows the recovery from N-type inactivation.	Histidine	80-89	potassium voltage-gated channel subfamily A member 4 S homeolog	Xenopus laevis	29-34
10896994-1	2000	BACKGROUND: Recently, fragile histidine triad (FHIT) gene abnormality has been thought to be associated with several malignancies and smoking history.	Histidine	30-39	fragile histidine triad diadenosine triphosphatase	Homo sapiens	47-51
10777498-7	2000	Physical interactions between J-MTJ1 and BiP/GRP78 are stable and can be abolished by a single histidine --&gt; glutamine substitution in the highly conserved HPD motif shared by all DnaJ-like proteins.	Histidine	95-104	DnaJ heat shock protein family (Hsp40) member C14	Homo sapiens	183-187
10843688-5	2000	A histidine-tagged form of porcine sB7-1 (sB7-1-His) interacted with both CD28 and CTLA-4, and effectively blocked IL-2 production from human responder cells stimulated with PHA and either porcine or human stimulator cells.	Histidine	2-11	CD28 molecule	Homo sapiens	74-78
10850413-1	2000	Hemizygous deletions of the fragile histidine triad (FHIT) gene at human chromosome band 3p14.2 and down-regulation of its gene product are found in the majority of renal cell carcinomas (RCCs).	Histidine	36-45	fragile histidine triad diadenosine triphosphatase	Homo sapiens	53-57
10833391-1	2000	A functional recombinant mitochondrial ADP/ATP carrier from the yeast Saccharomyces cerevisiae that bears a six-histidine tag at the C-terminus, Anc2(His(6))p, has been engineered to allow its purification by immobilized metal-ion affinity chromatography (IMAC).	Histidine	112-121	ADP/ATP carrier protein PET9	Saccharomyces cerevisiae S288C	145-149
10833391-7	2000	Large-scale purification of Anc2(His(6))p-CATR and Anc2(His(6))p-BA complexes by IMAC will be of major interest for structural analysis of the ADP/ATP carrier.	Histidine	33-36	ADP/ATP carrier protein PET9	Saccharomyces cerevisiae S288C	28-32
10785382-2	2000	Thyrotropin-releasing hormone-degrading ectoenzyme is a member of the M1 family of Zn-dependent aminopeptidases and catalyzes the degradation of thyrotropin-releasing hormone (TRH; Glp-His-Pro-NH2).	Histidine	185-188	thyrotropin releasing hormone	Homo sapiens	0-29
10785382-2	2000	Thyrotropin-releasing hormone-degrading ectoenzyme is a member of the M1 family of Zn-dependent aminopeptidases and catalyzes the degradation of thyrotropin-releasing hormone (TRH; Glp-His-Pro-NH2).	Histidine	185-188	thyrotropin releasing hormone	Homo sapiens	145-174
10745077-8	2000	Based on the X-ray structural analysis of caspase-8, a main chain carbonyl oxygen appears to be involved in a catalytic triad with the active site Cys and His residues.	Histidine	155-158	caspase 8	Homo sapiens	42-51
10715127-0	2000	Histidine 450 plays a critical role in catalysis and, with Ca2+, contributes to the substrate specificity of aminopeptidase A.	Histidine	0-9	glutamyl aminopeptidase	Mus musculus	109-125
10715127-3	2000	Aligning the sequences of the mouse APA, APN, and other monozinc aminopeptidases led to the identification of a conserved histidine (His 450 in mouse APA).	Histidine	122-131	glutamyl aminopeptidase	Mus musculus	36-39
10715127-3	2000	Aligning the sequences of the mouse APA, APN, and other monozinc aminopeptidases led to the identification of a conserved histidine (His 450 in mouse APA).	Histidine	122-131	glutamyl aminopeptidase	Mus musculus	150-153
10715127-3	2000	Aligning the sequences of the mouse APA, APN, and other monozinc aminopeptidases led to the identification of a conserved histidine (His 450 in mouse APA).	Histidine	133-136	glutamyl aminopeptidase	Mus musculus	36-39
10715127-3	2000	Aligning the sequences of the mouse APA, APN, and other monozinc aminopeptidases led to the identification of a conserved histidine (His 450 in mouse APA).	Histidine	133-136	glutamyl aminopeptidase	Mus musculus	150-153
10715127-10	2000	Furthermore, His 450, together with Ca2+, may contribute to the substrate specificity of APA for N-terminal acidic amino acid residues.	Histidine	13-16	glutamyl aminopeptidase	Mus musculus	89-92
10773313-2	2000	The expressed protein (esigmaNS) consistent with the expected molecular size of the avian reovirus protein sigmaNS synthesized in infected cells was readily purified by His-Bind Resin.	Histidine	169-172	sigma-NS protein	Avian orthoreovirus	24-31
10652418-1	2000	The fhit (fragile histidine triad) gene on chromosome 3p14.2 is a candidate tumour-suppressor gene; its abnormal transcripts are detected in several human cancers.	Histidine	18-27	fragile histidine triad diadenosine triphosphatase	Homo sapiens	4-8
10652256-7	2000	The HNE-mediated activation of caspases, cleavage of PARP and DNA fragmentation were blocked by antioxidants cysteine, N-acety-L-cysteine and dithiothreitol, but not by two other HNE-reactive amino acids lysine and histidine, or by cystine, the oxidized form of cysteine.	Histidine	215-224	caspase 8	Homo sapiens	31-39
10888270-1	2000	Histamine is produced from histidine by histidine decarboxylase (HDC) in many cells including normal and malignant lymphocytes.	Histidine	27-36	histidine decarboxylase	Homo sapiens	40-63
10888270-1	2000	Histamine is produced from histidine by histidine decarboxylase (HDC) in many cells including normal and malignant lymphocytes.	Histidine	27-36	histidine decarboxylase	Homo sapiens	65-68
11255560-1	2000	Gonadotropin-releasing hormone (GnRH) is a decapeptide (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly.NH2) which is produced from a precursor polypeptide in hypothalamic neurons and secreted in a pulsatile fashion to stimulate the secretion of LH and FSH via its interaction with a cognate receptor on gonadotropes.	Histidine	61-64	gonadotropin releasing hormone 1	Homo sapiens	0-30
11255560-1	2000	Gonadotropin-releasing hormone (GnRH) is a decapeptide (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly.NH2) which is produced from a precursor polypeptide in hypothalamic neurons and secreted in a pulsatile fashion to stimulate the secretion of LH and FSH via its interaction with a cognate receptor on gonadotropes.	Histidine	61-64	gonadotropin releasing hormone 1	Homo sapiens	32-36
11025357-2	2000	AIMS: This study was designed to investigate how water extracts (WE) of Hp applied on rat gastric mucosa affect gastric secretion and mucosal histamine concentration as well as the gene expression for histamine decarboxylase (HDC), the key enzyme converting histidine to histamine and for interleukin-1beta (IL-1beta), the important proinflammatory cytokine.	Histidine	258-267	histidine decarboxylase	Rattus norvegicus	201-224
11025357-2	2000	AIMS: This study was designed to investigate how water extracts (WE) of Hp applied on rat gastric mucosa affect gastric secretion and mucosal histamine concentration as well as the gene expression for histamine decarboxylase (HDC), the key enzyme converting histidine to histamine and for interleukin-1beta (IL-1beta), the important proinflammatory cytokine.	Histidine	258-267	histidine decarboxylase	Rattus norvegicus	226-229
10585575-1	2000	We have reported a significant frequency of an alteration of the fragile histidine triad (fhit) gene in squamous-cell carcinoma of the uterine cervix (series 1).	Histidine	73-82	fragile histidine triad diadenosine triphosphatase	Homo sapiens	90-94
10984068-2	2000	The hypothalamic thyrotropin-releasing hormone (TRH) was the first chemically defined hypophyseotropic hormone with the primary structure pGLU-HIS-PRO.NH2.	Histidine	143-146	thyrotropin releasing hormone	Homo sapiens	17-46
10984068-2	2000	The hypothalamic thyrotropin-releasing hormone (TRH) was the first chemically defined hypophyseotropic hormone with the primary structure pGLU-HIS-PRO.NH2.	Histidine	143-146	thyrotropin releasing hormone	Homo sapiens	48-51
10574918-2	1999	We describe the novel properties of a carboxyl-terminal histidine-tagged recombinant HCII (rHCII-CHis(6)).	Histidine	56-65	serpin family D member 1	Homo sapiens	85-89
10559306-2	1999	To better understand the structure and function of the protein, C-terminally His-tagged NSP2 was expressed in bacteria and purified to homogeneity.	Histidine	77-80	reticulon 2	Homo sapiens	88-92
10567378-8	1999	A small fragment of p300 containing the carboxyl-terminal cysteine/histidine-rich domain, sufficient to interact with GATA-5, prevents transcriptional activation by GATA-5 as a dominant-negative mutant.	Histidine	67-76	E1A binding protein p300	Homo sapiens	20-24
10589760-1	1999	To determine whether transcriptional alterations of the fragile histidine triad (FHIT) gene play a role in the development and progression of human hepatocellular carcinoma (HCC) we used reverse transcription-PCR to examine mRNA FHIT expression in 28 paired samples of HCC (24 in cirrhotic and 4 in noncirrhotic livers) and matched noncancerous tissue and in 10 normal livers.	Histidine	64-73	fragile histidine triad diadenosine triphosphatase	Homo sapiens	81-85
10512701-0	1999	Conservation of structure and function among histidine-containing phosphotransfer (HPt) domains as revealed by the crystal structure of YPD1.	Histidine	45-54	Ypd1p	Saccharomyces cerevisiae S288C	136-140
10512701-7	1999	Structure-based comparisons of YPD1 to other proteins having a similar function, such as the Escherichia coli ArcB histidine-containing phosphotransfer (HPt) domain and the P1 domain of the CheA kinase, revealed that the helical bundle and several structural features around the active-site histidine residue are conserved between the prokaryotic and eukaryotic kingdoms.	Histidine	115-124	Ypd1p	Saccharomyces cerevisiae S288C	31-35
10512701-7	1999	Structure-based comparisons of YPD1 to other proteins having a similar function, such as the Escherichia coli ArcB histidine-containing phosphotransfer (HPt) domain and the P1 domain of the CheA kinase, revealed that the helical bundle and several structural features around the active-site histidine residue are conserved between the prokaryotic and eukaryotic kingdoms.	Histidine	291-300	Ypd1p	Saccharomyces cerevisiae S288C	31-35
10512701-8	1999	Despite limited amino acid sequence homology among HPt domains, our analysis of YPD1 as a prototypical family member, indicates that these phosphotransfer domains are likely to share a similar fold and common features with regard to response regulator binding and mechanism for histidine-aspartate phosphoryl transfer.	Histidine	278-287	Ypd1p	Saccharomyces cerevisiae S288C	80-84
35077997-1	2022	Protein disulfide isomerase (PDI), an oxidoreductase, possesses two vicinal cysteines in the -Cys-Gly-His-Cys-motif that either form a disulfide bridge (S-S) or exist in a sulfhydryl form (-SH), forming oxidized or reduced PDI, respectively.	Histidine	102-105	prolyl 4-hydroxylase subunit beta	Homo sapiens	0-27
35077997-1	2022	Protein disulfide isomerase (PDI), an oxidoreductase, possesses two vicinal cysteines in the -Cys-Gly-His-Cys-motif that either form a disulfide bridge (S-S) or exist in a sulfhydryl form (-SH), forming oxidized or reduced PDI, respectively.	Histidine	102-105	prolyl 4-hydroxylase subunit beta	Homo sapiens	29-32
35077997-1	2022	Protein disulfide isomerase (PDI), an oxidoreductase, possesses two vicinal cysteines in the -Cys-Gly-His-Cys-motif that either form a disulfide bridge (S-S) or exist in a sulfhydryl form (-SH), forming oxidized or reduced PDI, respectively.	Histidine	102-105	prolyl 4-hydroxylase subunit beta	Homo sapiens	223-226
35437514-5	2022	The first approach demonstrates single-color fluorescent imaging of ACE2-GFPSpark binding to His-tagged S1-Receptor Binding Domain (RBD-His) immobilized beads.	Histidine	93-96	angiotensin converting enzyme 2	Homo sapiens	68-72
35142326-0	2022	Importance of Ile71 in beta-actin on histidine methyltransferase SETD3 catalysis.	Histidine	37-46	SET domain containing 3, actin histidine methyltransferase	Homo sapiens	65-70
15769590-2	2005	A histidine-containing phosphotransfer protein, YPD1, represents a bifurcation point between the SLN1-YPD1-SSK1 pathway responsible for osmotic stress responses and the SLN1-YPD1-SKN7 pathway involved in cell wall biosynthesis and cell cycle control.	Histidine	2-11	Ypd1p	Saccharomyces cerevisiae S288C	102-106
35038117-6	2022	Using mutant PrP (H95A, H110A), we also investigated whether histidine residues outside the octarepeat region in PrP, which is known to bind tPA and Plg, are also involved in their binding.	Histidine	61-70	plasminogen	Mus musculus	149-152
35038117-9	2022	The mutant form of PrP did not stimulate Plg activation to the same degree as apo-PrP indicating that the histidine residues outside the octarepeat region are also involved in binding to tPA and Plg.	Histidine	106-115	plasminogen	Mus musculus	195-198
15769590-2	2005	A histidine-containing phosphotransfer protein, YPD1, represents a bifurcation point between the SLN1-YPD1-SSK1 pathway responsible for osmotic stress responses and the SLN1-YPD1-SKN7 pathway involved in cell wall biosynthesis and cell cycle control.	Histidine	2-11	histidine kinase	Saccharomyces cerevisiae S288C	169-173
15769590-2	2005	A histidine-containing phosphotransfer protein, YPD1, represents a bifurcation point between the SLN1-YPD1-SSK1 pathway responsible for osmotic stress responses and the SLN1-YPD1-SKN7 pathway involved in cell wall biosynthesis and cell cycle control.	Histidine	2-11	Ypd1p	Saccharomyces cerevisiae S288C	102-106
15851033-4	2005	The crystal structure of the PKCdelta C2 domain in complex with an optimal phosphopeptide reveals a new mode of phosphotyrosine binding in which the phosphotyrosine moiety forms a ring-stacking interaction with a histidine residue of the C2 domain.	Histidine	213-222	protein kinase C delta	Homo sapiens	29-37
10504263-1	1999	MRE-binding transcription factor-1 (MTF-1) contains six Cys(2)-His(2) zinc finger sequences, and it has been suggested that the zinc finger domain itself may function as a zinc sensor in zinc-activated expression of metallothioneins (MTs).	Histidine	63-66	metal regulatory transcription factor 1	Homo sapiens	0-34
10504263-1	1999	MRE-binding transcription factor-1 (MTF-1) contains six Cys(2)-His(2) zinc finger sequences, and it has been suggested that the zinc finger domain itself may function as a zinc sensor in zinc-activated expression of metallothioneins (MTs).	Histidine	63-66	metal regulatory transcription factor 1	Homo sapiens	36-41
10440747-1	1999	The FHIT (fragile histidine triad) gene has been recently identified and cloned at chromosome 3p14.2 including FRA3B, the most common fragile site in the human genome.	Histidine	18-27	fragile histidine triad diadenosine triphosphatase	Homo sapiens	4-8
10440747-1	1999	The FHIT (fragile histidine triad) gene has been recently identified and cloned at chromosome 3p14.2 including FRA3B, the most common fragile site in the human genome.	Histidine	18-27	fragile histidine triad diadenosine triphosphatase	Homo sapiens	111-116
15680477-1	2005	The hexapeptide Thr-Gly-Glu-Asn-His-Arg (HLDF-6), which was first identified as an active fragment of the human leukemia differentiation factor (HLDF) molecule, displays differentiation-inducing, neuroprotective and anti-drug abuse activities.	Histidine	32-35	ribosomal protein S21	Homo sapiens	41-45
15680477-1	2005	The hexapeptide Thr-Gly-Glu-Asn-His-Arg (HLDF-6), which was first identified as an active fragment of the human leukemia differentiation factor (HLDF) molecule, displays differentiation-inducing, neuroprotective and anti-drug abuse activities.	Histidine	32-35	ribosomal protein S21	Homo sapiens	106-143
15680477-1	2005	The hexapeptide Thr-Gly-Glu-Asn-His-Arg (HLDF-6), which was first identified as an active fragment of the human leukemia differentiation factor (HLDF) molecule, displays differentiation-inducing, neuroprotective and anti-drug abuse activities.	Histidine	32-35	ribosomal protein S21	Homo sapiens	145-149
10416589-0	1999	Induction of apoptosis and inhibition of tumorigenicity and tumor growth by adenovirus vector-mediated fragile histidine triad (FHIT) gene overexpression.	Histidine	111-120	fragile histidine triad diadenosine triphosphatase	Homo sapiens	128-132
15736924-8	2005	The Zn-EXAFS of WT CCS showed a 3-4 histidine ligand environment that is consistent with Zn binding in the SOD-like domain II of CCS.	Histidine	36-45	copper chaperone for superoxide dismutase	Homo sapiens	19-22
10416589-1	1999	We studied the effects of fragile histidine triad (FHIT) gene overexpression mediated by an adenoviral vector, Ad-FHIT, on cell proliferation, apoptosis, and cell cycle kinetics in human cancer cells and on tumorigenicity and tumor growth in nude mice.	Histidine	34-43	fragile histidine triad diadenosine triphosphatase	Homo sapiens	51-55
15736924-8	2005	The Zn-EXAFS of WT CCS showed a 3-4 histidine ligand environment that is consistent with Zn binding in the SOD-like domain II of CCS.	Histidine	36-45	copper chaperone for superoxide dismutase	Homo sapiens	129-132
16851400-2	2005	Based on these calculations, we have proposed a model of CcO proton pumping that involves His291, one of the Cu(B) histidine ligands, which was found to respond to redox changes of the enzyme Fe(a)(3)-Cu(B) catalytic center.	Histidine	115-124	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	57-60
10410979-3	1999	Employing this method, a recombinant C3a (rC3a) anaphylatoxin with a His-tag at its N-terminus could be shown to bind to C3a receptor (C3aR)-expressing RBL-2H3 transfectants with a half-maximal effective concentration (EC50) of about 3 nM which is well within the range of published affinity constants.	Histidine	69-72	complement C3a receptor 1	Homo sapiens	121-133
10410979-3	1999	Employing this method, a recombinant C3a (rC3a) anaphylatoxin with a His-tag at its N-terminus could be shown to bind to C3a receptor (C3aR)-expressing RBL-2H3 transfectants with a half-maximal effective concentration (EC50) of about 3 nM which is well within the range of published affinity constants.	Histidine	69-72	complement C3a receptor 1	Homo sapiens	135-139
10358012-0	1999	Histidine 179 mutants of GTP cyclohydrolase I catalyze the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone triphosphate.	Histidine	0-9	GTP cyclohydrolase 1	Homo sapiens	25-45
15674328-1	2005	This study aimed to (a) determine if DNA methylation is a mechanism of WWOX (WW domain containing oxidoreductase) and FHIT (fragile histidine triad) inactivation in lung, breast and bladder cancers; (b) examine distinct methylation patterns in neoplastic and adjacent tissues and (c) seek correlation of methylation patterns with disease status.	Histidine	132-141	fragile histidine triad diadenosine triphosphatase	Homo sapiens	118-122
10360578-8	1999	The Phe-X-His-X2-His portion of the CRIB motif and the alpha-helix appear to mediate sensitivity to the nucleotide switch through contacts to residues 36-40 of Cdc42.	Histidine	10-13	cell division cycle 42	Homo sapiens	160-165
15716133-1	2005	Cicer arietinum GRP1 and GRP2 are rich in glycine interposed with histidine and tyrosine.	Histidine	66-75	glycine-rich cell wall structural protein	Cicer arietinum	16-20
10223242-3	1999	Recently, the fragile histidine triad (FHIT) gene, which is frequently lost in many cancers, was identified as a candidate tumor suppressor gene at chromosome 3p locus 14.2.	Histidine	22-31	fragile histidine triad diadenosine triphosphatase	Homo sapiens	39-43
15716133-1	2005	Cicer arietinum GRP1 and GRP2 are rich in glycine interposed with histidine and tyrosine.	Histidine	66-75	glycine-rich protein 2	Cicer arietinum	25-29
15642354-3	2005	We investigate here whether ZIP14 (SLC39A14), lacking the initial histidine in this motif, is still able to transport zinc.	Histidine	66-75	solute carrier family 39 member 14	Homo sapiens	28-33
10402203-3	1999	Here, we show that two neighboring histidine residues on NR2A represent the critical determinant (termed the "short spacer") for high-affinity, voltage-independent Zn2+ inhibition using the Xenopus oocyte expression system and site-directed mutagenesis.	Histidine	35-44	glutamate receptor, ionotropic, N-methyl D-aspartate 2A L homeolog	Xenopus laevis	57-61
10402203-4	1999	Mutation of either one of these two histidine residues (H42 and H44) in the extracellular N-terminal domain of NR2A shifted the IC50 for high-affinity Zn2+ inhibition approximately 200-fold without affecting the EC50 of the coagonists NMDA and glycine.	Histidine	36-45	glutamate receptor, ionotropic, N-methyl D-aspartate 2A L homeolog	Xenopus laevis	111-115
15642354-3	2005	We investigate here whether ZIP14 (SLC39A14), lacking the initial histidine in this motif, is still able to transport zinc.	Histidine	66-75	solute carrier family 39 member 14	Homo sapiens	35-43
10231019-3	1999	Histidine, cysteine and glycine were shown to block the effect of GAA.	Histidine	0-9	alpha glucosidase	Homo sapiens	66-69
15628880-10	2005	In addition, we have examined the roles of several conserved amino acid residues surrounding the phosphorylatable histidine (H64) of YPD1 using phosphoryl transfer reactions involving YPD1 mutants.	Histidine	114-123	Ypd1p	Saccharomyces cerevisiae S288C	133-137
10050767-6	1999	The parathyroid hormone-related protein(1-34) structure and the structure of human parathyroid hormone(1-37) as well as human parathyroid hormone(1-34) are highly similar, except for the well defined turn, His-14-Ser-17, present in parathyroid hormone.	Histidine	206-209	parathyroid hormone like hormone	Homo sapiens	4-39
15629079-8	2005	Western blot analysis showed the expressed Tat fusion protein with relative molecular mass (M(r)) 24 000 could bind to anti-His-tag monoclonal antibody.	Histidine	124-127	tyrosine aminotransferase	Homo sapiens	43-46
15609997-5	2004	On the contrary, finger 1 can use only two residues for DNA recognition, Lys550 and His553 at positions -1 and 3 of the helix, and has more relaxed sequence and site specificity than other Cys(2)His(2) zinc fingers.	Histidine	84-87	Yip1 domain family member 1	Homo sapiens	17-25
10022949-1	1999	Histidine auxotrophs of wild-type strain I-182 of Candida oleophila, produced using ethyl methanesulfonate, were transformed with plasmids containing the HIS3, HIS4 and HIS5 genes of Saccharomyces cerevisiae.	Histidine	0-9	histidinol-phosphate transaminase	Saccharomyces cerevisiae S288C	169-173
10022949-2	1999	Histidine auxotrophy was complemented by the HIS5 gene of S. cerevisiae.	Histidine	0-9	histidinol-phosphate transaminase	Saccharomyces cerevisiae S288C	45-49
15506957-5	2004	Our aim is to study the consequences of putative GR (glucagon receptor)-activating mutations using glucagon and partial agonist des-His(1)-[Glu(9)]glucagon amide (glucagon-NH(2)).	Histidine	132-135	glucagon receptor	Homo sapiens	53-70
15537357-0	2004	Centrally acting and metabolically stable thyrotropin-releasing hormone analogues by replacement of histidine with substituted pyridinium.	Histidine	100-109	thyrotropin releasing hormone	Rattus norvegicus	42-71
15537357-1	2004	Metabolically stable and centrally acting thyrotropin-releasing hormone (TRH) analogues were designed by replacing the central histidine with substituted pyridinium moieties.	Histidine	127-136	thyrotropin releasing hormone	Rattus norvegicus	42-71
15537357-1	2004	Metabolically stable and centrally acting thyrotropin-releasing hormone (TRH) analogues were designed by replacing the central histidine with substituted pyridinium moieties.	Histidine	127-136	thyrotropin releasing hormone	Rattus norvegicus	73-76
15328354-5	2004	These modes, also identified in Cu,Zn-SOD by using (15)N labeling, showed that the electronic properties of the histidine Ntau ligands of copper are mostly affected upon copper reduction.	Histidine	112-121	superoxide dismutase [Cu-Zn]	Bos taurus	32-41
9885976-1	1999	Occurrence of abnormal transcripts of the FHIT (fragile histidine triad) gene has been reported in various types of cancer.	Histidine	56-65	fragile histidine triad diadenosine triphosphatase	Homo sapiens	42-46
10191473-1	1999	The peptide Val-Arg-Arg-Pro-Asn-Leu-His-Pro-Ser-Phe-Ile-Ala-Ile-Pro-Pro- Lys-Lys-Ile, which corresponds to residues 84-101 of human kappa-casein, has been synthesized and its conformation preferences determined by 1H-nuclear magnetic resonance spectroscopy in dimethyl sulphoxide.	Histidine	36-39	casein kappa	Homo sapiens	132-144
15339932-3	2004	However, the Cys-X2-His-X16-Cys-X2-Cys (CHCC) motif present near the C terminus of NEIL2 is distinct from the zinc finger motifs of Nei/Fpg, which are of the C4 type.	Histidine	20-23	nei like DNA glycosylase 2	Homo sapiens	83-88
10048929-1	1999	The solution structure of the first protein-protein complex of the bacterial phosphoenolpyruvate: sugar phosphotransferase system between the N-terminal domain of enzyme I (EIN) and the histidine-containing phosphocarrier protein HPr has been determined by NMR spectroscopy, including the use of residual dipolar couplings that provide long-range structural information.	Histidine	186-195	haptoglobin-related protein	Homo sapiens	230-233
10447101-2	1999	Replacement of His with Ala resulted in [Ala6]-MT-II with affinity and agonist potency at human MC3, MC4, and MC5 receptors similar to MT-II.	Histidine	15-18	melanocortin 3 receptor	Homo sapiens	96-99
15504035-9	2004	The purified TTP was shown to be intact by N-terminal His-tag purification, C-terminal peptide sequencing, and mass spectrometry analysis.	Histidine	54-57	ZFP36 ring finger protein	Homo sapiens	13-16
15464720-6	2004	The competitive inhibitor that is not at all digested by DPP III, Hisprophen (His-Pro-Phe-His-Leu-d-Leu-Val-Tyr), has been determined.	Histidine	66-69	dipeptidyl peptidase 3	Homo sapiens	57-64
9990655-2	1998	To inhibit AT2 receptors we used their selective antagonist CGP 42112A (nicotinic acid-Tyr-N-benzoxyl-carbonyl-Arg-Lys-His-Pro-Ile-OH).	Histidine	119-122	angiotensin II receptor, type 2	Rattus norvegicus	11-14
15464720-6	2004	The competitive inhibitor that is not at all digested by DPP III, Hisprophen (His-Pro-Phe-His-Leu-d-Leu-Val-Tyr), has been determined.	Histidine	78-81	dipeptidyl peptidase 3	Homo sapiens	57-64
9757042-2	1998	The importance of the N-terminal amino acid, histidine, for the bioactivity of GLP-1(7-36) in the central nervous system was suggested, though the role for C-terminal amino acids in the central nervous system has not been reported.	Histidine	45-54	glucagon	Gallus gallus	79-84
15646642-8	2004	The major site of interferon alpha-2b monopegylation is histidine (His34), with additional pegylation sites at lysine and cysteine residues.	Histidine	56-65	interferon alpha 2	Homo sapiens	18-37
9751525-4	1998	We used immunocytochemical methods to visualize histamine, histidine decarboxylase (HDC, the enzyme that converts histidine to histamine), and the type 1 vesicular monoamine transporter (VMAT1, the protein responsible for moving histamine into vesicles for storage and release).	Histidine	59-68	histidine decarboxylase	Rattus norvegicus	84-87
15231689-1	2004	Fragile histidine triad (FHIT) gene plays an important role in the pathogenesis of lung cancer.	Histidine	8-17	fragile histidine triad diadenosine triphosphatase	Homo sapiens	25-29
9827668-2	1998	The limited proteolysis of thyrotropin-releasing hormone (TRH) by Pyroglutamate aminopeptidase yields cyclo(His-Pro) or CHP, a new biopeptide associated with a variety of pharmacological activities, including regulation of body temperature, inhibition of prolactin secretion, and modulation of motor functions.	Histidine	108-111	thyrotropin releasing hormone	Homo sapiens	27-56
9827668-2	1998	The limited proteolysis of thyrotropin-releasing hormone (TRH) by Pyroglutamate aminopeptidase yields cyclo(His-Pro) or CHP, a new biopeptide associated with a variety of pharmacological activities, including regulation of body temperature, inhibition of prolactin secretion, and modulation of motor functions.	Histidine	108-111	thyrotropin releasing hormone	Homo sapiens	58-61
15505035-4	2004	FOXC1-enriched chromatin complexes were isolated by using the tight electrostatic interaction between histidine residues of the recombinant FOXC1 protein and nickel.	Histidine	102-111	forkhead box C1	Homo sapiens	0-5
15505035-4	2004	FOXC1-enriched chromatin complexes were isolated by using the tight electrostatic interaction between histidine residues of the recombinant FOXC1 protein and nickel.	Histidine	102-111	forkhead box C1	Homo sapiens	140-145
9729477-3	1998	These UBPs have virtually identical catalytic domains spanning the sequence of UBP41 between the active-site Cys and the His box (95% identity).	Histidine	121-124	ubiquitin specific peptidase 2	Gallus gallus	79-84
15299007-8	2004	H2A.Z modifies the surface of a canonical nucleosome by creating an extended acidic patch and a metal ion-binding site stabilized by two histidine residues.	Histidine	137-146	H2A.Z variant histone 1 L homeolog	Xenopus laevis	0-5
15299007-12	2004	Remarkably, modification of a single stabilizing histidine residue located on the exposed surface of an H2A.Z containing nucleosome was sufficient to disrupt normal trunk formation mimicking the effect observed by RNA interference.	Histidine	49-58	H2A.Z variant histone 1 L homeolog	Xenopus laevis	104-109
9733991-3	1998	RcAAP1-mediated histidine uptake was pH dependent with highest transport rates at acidic pH; it was sensitive to protonophores and uncouplers and the Km for histidine uptake was 96 microM.	Histidine	16-25	amino acid permease 3	Ricinus communis	0-6
15383297-4	2004	A comparative sequence alignment of Pf HGPRT with the human, Tricomonus foetus and Toxoplasma gondii HGPRT, coupled with the 3D structural alignment between these enzymes indicated that a histidine residue at position 196 of the Pf HGPRT sequence was located in the close proximity to the active site.	Histidine	188-197	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	39-44
9733991-3	1998	RcAAP1-mediated histidine uptake was pH dependent with highest transport rates at acidic pH; it was sensitive to protonophores and uncouplers and the Km for histidine uptake was 96 microM.	Histidine	157-166	amino acid permease 3	Ricinus communis	0-6
9705508-1	1998	Bas1p is a yeast transcription factor that activates expression of purine and histidine biosynthesis genes in response to extracellular purine limitation.	Histidine	78-87	Bas1p	Saccharomyces cerevisiae S288C	0-5
15383297-4	2004	A comparative sequence alignment of Pf HGPRT with the human, Tricomonus foetus and Toxoplasma gondii HGPRT, coupled with the 3D structural alignment between these enzymes indicated that a histidine residue at position 196 of the Pf HGPRT sequence was located in the close proximity to the active site.	Histidine	188-197	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	101-106
15383297-4	2004	A comparative sequence alignment of Pf HGPRT with the human, Tricomonus foetus and Toxoplasma gondii HGPRT, coupled with the 3D structural alignment between these enzymes indicated that a histidine residue at position 196 of the Pf HGPRT sequence was located in the close proximity to the active site.	Histidine	188-197	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	101-106
15388974-8	2004	Through transient expression assays with T87 protoplasts, it is shown that the intracellular localization profiles of the phosphorelay intermediate Arabidopsis histidine-containing phosphotransfer factor (AHPs; e.g., AHP1 and AHP4) were markedly affected in response to cytokinin, but those of type-A ARRs were not (e.g., ARR15 and ARR16).	Histidine	160-169	histidine-containing phosphotransmitter 1	Arabidopsis thaliana	217-221
9681494-3	1998	Bufo insulin was, however, more potent (4-fold) than human insulin in inhibiting the binding of [125I-Tyr-A14] insulin to the soluble full-length recombinant human insulin receptor, which is probably a consequence of the substitution (Thr --&gt; His) at position A-8.	Histidine	246-249	insulin receptor	Homo sapiens	164-180
15388974-8	2004	Through transient expression assays with T87 protoplasts, it is shown that the intracellular localization profiles of the phosphorelay intermediate Arabidopsis histidine-containing phosphotransfer factor (AHPs; e.g., AHP1 and AHP4) were markedly affected in response to cytokinin, but those of type-A ARRs were not (e.g., ARR15 and ARR16).	Histidine	160-169	HPT phosphotransmitter 4	Arabidopsis thaliana	226-230
15358233-5	2004	Furthermore, His-p53 and FLAG-XPG, but not PCNA, stimulated the Tg DNA glycosylase/AP lyase activity of GST-NTH1 or NTH1.	Histidine	13-16	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	83-91
9671501-2	1998	We purified a polyhistidine-tagged form of Prt1p (His-Prt1p) by Ni2+ affinity and gel filtration chromatography and obtained a complex of approximately 600 kDa composed of six polypeptides whose copurification was completely dependent on the polyhistidine tag on His-Prt1p.	Histidine	263-266	translation initiation factor eIF3 core subunit b	Saccharomyces cerevisiae S288C	43-48
9671501-3	1998	All five polypeptides associated with His-Prt1p were identified by mass spectrometry, and four were found to be the other putative homologs of human eIF3 subunits encoded in S. cerevisiae: YBR079c/Tif32p, Nip1p, Tif34p, and YDR429c/Tif35p.	Histidine	38-41	eukaryotic translation initiation factor 3 subunit B	Homo sapiens	42-47
15299133-4	2004	AtPng1p contains the Cys-His-Asp triad present in the TGase catalytic domain.	Histidine	25-28	peptide-N-glycanase 1	Arabidopsis thaliana	0-7
15356332-7	2004	The purified ARR22 protein had the ability to undergo phosphorylation in vitro, when incubated with phospho-AHP5, indicating that ARR22 has the fundamental ability to participate into a His-Asp phosphorelay pathway in its own right.	Histidine	186-189	response regulator 22	Arabidopsis thaliana	130-135
15356332-12	2004	These results suggested that ARR22 might also be implicated, directly or indirectly, in the cytokinin-responsive His--&gt;Asp phophorelay signal transduction.	Histidine	113-116	response regulator 22	Arabidopsis thaliana	29-34
9665804-2	1998	All classical cadherins share common structural and functional properties, one of which is the cell adhesion recognition (CAR) sequence HAV (His-Ala-Val).	Histidine	141-144	SPG7 matrix AAA peptidase subunit, paraplegin	Homo sapiens	122-125
15161915-9	2004	Chemical protonation with diethyl pyrocarbonate of HGF histidine residues impeded the ability of 500 microM copper(II) to inhibit the binding of HGF to immobilized Met-IgG.	Histidine	55-64	hepatocyte growth factor	Homo sapiens	51-54
9675070-9	1998	The recombinant 6PGDH with His-tag was purified using the Ni-NTA affinity column supplied by Qiagen.	Histidine	27-30	6-phosphogluconate dehydrogenase, decarboxylating	Ovis aries	16-21
15161915-9	2004	Chemical protonation with diethyl pyrocarbonate of HGF histidine residues impeded the ability of 500 microM copper(II) to inhibit the binding of HGF to immobilized Met-IgG.	Histidine	55-64	hepatocyte growth factor	Homo sapiens	145-148
15161915-10	2004	Based on the NK1 domain structure, we propose that copper(II) may interact with HGF via the histidine residues in either N-terminal or kringle domains.	Histidine	92-101	hepatocyte growth factor	Homo sapiens	80-83
15236912-4	2004	The assay involves the capture of the Triton X-100 solubilized human CSF-1R, from HEK293E cells overexpressing histidine epitope-tagged CSF-1R (CSF-1R/HEK293E), with immobilized CSF-1R antibody and detection of phosphosphorylation of the activated receptor with a phosphotyrosine specific antibody.	Histidine	111-120	colony stimulating factor 1 receptor	Homo sapiens	136-142
9660202-5	1998	The IC50 of the best peptides is 30 microM which is close to the K(M) (6 microM) of EI for its natural substrate HPr (histidine containing phosphoryl carrier protein of the PTS).	Histidine	118-127	haptoglobin-related protein	Homo sapiens	113-116
15236912-4	2004	The assay involves the capture of the Triton X-100 solubilized human CSF-1R, from HEK293E cells overexpressing histidine epitope-tagged CSF-1R (CSF-1R/HEK293E), with immobilized CSF-1R antibody and detection of phosphosphorylation of the activated receptor with a phosphotyrosine specific antibody.	Histidine	111-120	colony stimulating factor 1 receptor	Homo sapiens	144-158
15236912-4	2004	The assay involves the capture of the Triton X-100 solubilized human CSF-1R, from HEK293E cells overexpressing histidine epitope-tagged CSF-1R (CSF-1R/HEK293E), with immobilized CSF-1R antibody and detection of phosphosphorylation of the activated receptor with a phosphotyrosine specific antibody.	Histidine	111-120	colony stimulating factor 1 receptor	Homo sapiens	136-142
9621287-5	1998	The fragile histidine triad (FHIT) gene is localized at the most common fragile site at chromosome 3p14.2.	Histidine	12-21	fragile histidine triad diadenosine triphosphatase	Homo sapiens	29-33
15239028-1	2004	OBJECTIVE: To determine the prognostic significance of p53 and fragile histidine triad (FHIT) expression in advanced oropharyngeal squamous cell carcinoma.	Histidine	71-80	fragile histidine triad diadenosine triphosphatase	Homo sapiens	88-92
9663674-8	1998	In the absence of PTS substrates, the HPr protein is phosphorylated by enzyme I at His-15.	Histidine	83-86	haptoglobin-related protein	Homo sapiens	38-41
15194464-4	2004	RESULTS: In the heart of the Cx40(EGFP/+) mice, EGFP signal was seen in the coronary arteries, the atria, the atrioventricular (AV) node and the His-Purkinje system.	Histidine	145-148	gap junction protein, alpha 5	Mus musculus	29-33
9600911-6	1998	Kinetic analysis indicates that a DNA-histidine complex may perform a reaction that is analogous to the first step of the proposed catalytic mechanism of RNase A, in which the imidazole group of histidine serves as a general base catalyst.	Histidine	38-47	ribonuclease A family member 1, pancreatic	Homo sapiens	154-161
15219888-1	2004	OBJECTIVE: Loss of the fragile histidine triad (Fhit) protein has been documented in cervical cancer and dysplasia.	Histidine	31-40	fragile histidine triad diadenosine triphosphatase	Homo sapiens	48-52
9600911-6	1998	Kinetic analysis indicates that a DNA-histidine complex may perform a reaction that is analogous to the first step of the proposed catalytic mechanism of RNase A, in which the imidazole group of histidine serves as a general base catalyst.	Histidine	195-204	ribonuclease A family member 1, pancreatic	Homo sapiens	154-161
9582292-2	1998	We characterized the consequences of the general control response upon the signal "amino acid starvation" induced by the histidine analogue 3-aminotriazole with respect to Gcn4p levels in more detail.	Histidine	121-130	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	172-177
15030318-2	2004	In this study we have identified Ser-304 (Phe301-Asp-His-Ser304-Pro-Asn-Lys307) as a major TCPTP phosphory-lation site and demonstrate that TC45, but not TC48, is phosphorylated on this site in vivo.	Histidine	53-56	protein tyrosine phosphatase non-receptor type 2	Homo sapiens	91-96
9575172-4	1998	Phosphoryl groups are transferred from the phosphoryl carrier protein phospho-HPr to His-10, hence to His-175 and finally to the 6" OH of the transported hexose.	Histidine	85-88	haptoglobin-related protein	Homo sapiens	78-81
15214434-0	2004	Partial alanine scan of mast cell degranulating peptide (MCD): importance of the histidine- and arginine residues.	Histidine	81-90	mucin 1, cell surface associated	Homo sapiens	57-60
9575172-4	1998	Phosphoryl groups are transferred from the phosphoryl carrier protein phospho-HPr to His-10, hence to His-175 and finally to the 6" OH of the transported hexose.	Histidine	102-105	haptoglobin-related protein	Homo sapiens	78-81
15169884-5	2004	Mutations of the cysteine or histidine residues in the C2HR motif abolish the interaction of Nizp1 with NSD1 and compromise the ability of Nizp1 to repress transcription.	Histidine	29-38	nuclear receptor binding SET domain protein 1	Homo sapiens	104-108
9546316-2	1998	Basophils and mast cells are the main sources of histamine, which is formed from L-histidine by histidine decarboxylase (HDC).	Histidine	81-92	histidine decarboxylase	Homo sapiens	96-119
9546316-2	1998	Basophils and mast cells are the main sources of histamine, which is formed from L-histidine by histidine decarboxylase (HDC).	Histidine	81-92	histidine decarboxylase	Homo sapiens	121-124
9516405-6	1998	Additionally, HIV-1 matrix protein trimer unit structures align to the His-HIVCA trimer units such that residues previously shown to interact with the HIV-1 gp120/gp41 envelope protein complex are oriented toward the hexamer cage holes.	Histidine	71-74	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	157-162
15144399-1	2004	Histidine decarboxylase (HDC) is an enzyme for decarboxylating l-histidine to histamine and is expressed in various types of cells including neuroendocrine tumors.	Histidine	63-74	histidine decarboxylase	Homo sapiens	0-23
9546649-8	1998	To compare the general biochemical properties of AATP2 with the known transport properties of AATP1 we cloned the entire AATP2 cDNA into plasmid pJT118, leading to the presence of an additional N-terminal histidine tag of 10 amino acids.	Histidine	205-214	AAA-ATPase 1	Arabidopsis thaliana	94-99
15144399-1	2004	Histidine decarboxylase (HDC) is an enzyme for decarboxylating l-histidine to histamine and is expressed in various types of cells including neuroendocrine tumors.	Histidine	63-74	histidine decarboxylase	Homo sapiens	25-28
14741044-5	2004	Homology modelling of furin"s pro-region revealed that residues Ile-60 and His-66 might be crucial in forming the binding interface with the catalytic domain, while residues Trp-34 and Phe-67 might be involved in maintaining a hydrophobic core within the pro-region itself.	Histidine	75-78	furin, paired basic amino acid cleaving enzyme	Homo sapiens	22-27
9497333-5	1998	During catalysis, a phosphoryl-enzyme intermediate is formed, and the phosphoryl acceptor in G6Pase is a His residue.	Histidine	105-108	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	93-99
9497333-7	1998	Active-site alignment of the vanadium-containing chloroperoxidase and G6Pases predicts that Arg-83, His-119, and His-176 in G6Pase contribute to the active site and that His-176 is the residue that covalently binds the phosphoryl moiety during catalysis.	Histidine	100-103	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	70-76
9497333-7	1998	Active-site alignment of the vanadium-containing chloroperoxidase and G6Pases predicts that Arg-83, His-119, and His-176 in G6Pase contribute to the active site and that His-176 is the residue that covalently binds the phosphoryl moiety during catalysis.	Histidine	113-116	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	70-76
9497333-7	1998	Active-site alignment of the vanadium-containing chloroperoxidase and G6Pases predicts that Arg-83, His-119, and His-176 in G6Pase contribute to the active site and that His-176 is the residue that covalently binds the phosphoryl moiety during catalysis.	Histidine	113-116	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	70-76
9497333-8	1998	This alignment also predicts that Arg-83, His-119, and His-176 reside on the same side of the endoplasmic reticulum membrane, which is supported by the recently predicted nine-transmembrane helical model for G6Pase.	Histidine	42-45	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	208-214
9497333-8	1998	This alignment also predicts that Arg-83, His-119, and His-176 reside on the same side of the endoplasmic reticulum membrane, which is supported by the recently predicted nine-transmembrane helical model for G6Pase.	Histidine	55-58	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	208-214
15096035-0	2004	Catalytic and structural role of a metal-free histidine residue in bovine Cu-Zn superoxide dismutase.	Histidine	46-55	superoxide dismutase [Cu-Zn]	Bos taurus	74-100
9497333-9	1998	We have previously shown that Arg-83 is involved in positioning the phosphate during catalysis and that His-119 is essential for G6Pase activity.	Histidine	104-107	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	129-135
9497333-10	1998	Here we demonstrate that substitution of His-176 with structurally similar or dissimilar amino acids inactivates the enzyme, suggesting that His-176 could be the phosphoryl acceptor in G6Pase during catalysis.	Histidine	41-44	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	185-191
9497333-10	1998	Here we demonstrate that substitution of His-176 with structurally similar or dissimilar amino acids inactivates the enzyme, suggesting that His-176 could be the phosphoryl acceptor in G6Pase during catalysis.	Histidine	141-144	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	185-191
15043985-6	2004	Full-length human genes for HDAC1 and HDAC3 were cloned into the pcDNA 3.1 vector containing a N-terminal His-tag with an enterokinase cleavage site.	Histidine	106-109	histone deacetylase 3	Homo sapiens	38-43
15013851-5	2004	In this report, the amino acid modification method was used for studies of His residues in the active site of P-PST and M-PST.	Histidine	75-78	sulfotransferase family 1A member 1	Homo sapiens	110-115
9442028-1	1998	Two histidine residues in glutamate decarboxylase from Escherichia coli, potential participants in catalysis because they are conserved among amino acid decarboxylases and because they are at the active site in the homologous enzyme ornithine decarboxylase, were mutated.	Histidine	4-13	ornithine decarboxylase 1	Homo sapiens	233-256
15013851-7	2004	Diethylpyrocarbonate inactivation kinetic data suggest that there is one His residue in the active site that is critical for catalytic activity of both P-PST and M-PST.	Histidine	73-76	sulfotransferase family 1A member 1	Homo sapiens	152-157
15013851-9	2004	The experimental results agree with amino acid sequence alignment, mutation, and the crystal structures of P-PST and M-PST and suggest that His108 is the only critical His residue in both P-PST and M-PST.	Histidine	140-143	sulfotransferase family 1A member 1	Homo sapiens	107-112
9492319-3	1998	Purification of the denatured fusion protein was simplified greatly by the introduction of a C-terminal histidine anchor, leading to 255 mg pure GST-PrPc-His6/l bacterial broth, which could be refolded easily by dilution in 20 mM Tris, 5 mM dithiothreitol, 1 mM EDTA, pH 9.0.	Histidine	104-113	glutathione S-transferase	Mesocricetus auratus	145-148
15013851-9	2004	The experimental results agree with amino acid sequence alignment, mutation, and the crystal structures of P-PST and M-PST and suggest that His108 is the only critical His residue in both P-PST and M-PST.	Histidine	140-143	sulfotransferase family 1A member 1	Homo sapiens	188-193
14976524-1	2004	The fragile histidine triad (FHIT) gene, located at chromosome 3p14.2, is deleted in many solid tumors, including lung cancer.	Histidine	12-21	fragile histidine triad diadenosine triphosphatase	Homo sapiens	29-33
14718531-0	2004	Histidine 167 is the phosphate acceptor in glucose-6-phosphatase-beta forming a phosphohistidine enzyme intermediate during catalysis.	Histidine	0-9	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	43-64
9425070-0	1998	Conformational fluctuations in deoxy hemoglobin revealed as a major contributor to anionic modulation of function through studies of the oxygenation and oxidation of hemoglobins A0 and Deer Lodge beta2(NA2)His --&gt; Arg.	Histidine	206-209	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	196-201
14718531-7	2004	Using [(32)P]Glc-6-P coupled with cyanogen bromide mapping, we demonstrated that the phosphate acceptor in Glc-6-Pase-beta is His(167) and that it lies inside the ER lumen with the active site residues, Arg(79) and His(114).	Histidine	126-129	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	107-117
14718531-7	2004	Using [(32)P]Glc-6-P coupled with cyanogen bromide mapping, we demonstrated that the phosphate acceptor in Glc-6-Pase-beta is His(167) and that it lies inside the ER lumen with the active site residues, Arg(79) and His(114).	Histidine	215-218	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	107-117
15026336-1	2004	The human FHIT (fragile histidine triad) gene is a putative tumor suppressor gene located at chromosome region 3p14.2.	Histidine	24-33	fragile histidine triad diadenosine triphosphatase	Homo sapiens	10-14
15026987-0	2004	An essential role for the His-8 residue of the SDF-1alpha-chimeric, tropism-redirected Env protein of the Moloney murine leukemia virus in regulating postbinding fusion events.	Histidine	26-29	endogenous retrovirus group K member 6, envelope	Homo sapiens	87-90
15026987-9	2004	These results indicate that the His-8 residue of the S3-D84K Env protein is indispensable and may be fully functional in postbinding membrane fusion.	Histidine	32-35	endogenous retrovirus group K member 6, envelope	Homo sapiens	61-64
15026987-10	2004	CONCLUSIONS: Insertion of a ligand at Pro-79 of the Moloney MLV Env protein has proved to be a valuable strategy for constructing direct targeting retroviral vectors, since it permits the formation of a redirected Env protein without ecotropism, and it does not disrupt the function of the essential His-8 residue.	Histidine	300-303	endogenous retrovirus group K member 6, envelope	Homo sapiens	64-67
15026987-10	2004	CONCLUSIONS: Insertion of a ligand at Pro-79 of the Moloney MLV Env protein has proved to be a valuable strategy for constructing direct targeting retroviral vectors, since it permits the formation of a redirected Env protein without ecotropism, and it does not disrupt the function of the essential His-8 residue.	Histidine	300-303	endogenous retrovirus group K member 6, envelope	Homo sapiens	214-217
14746454-3	2004	The bacterial PI-PLC has no sequence homology with known glucose-6-phosphatase enzymes, which need His, Arg, and negatively charged residues (Asp or Glu) at the active site.	Histidine	99-102	phospholipase C beta 1	Homo sapiens	14-20
14746454-3	2004	The bacterial PI-PLC has no sequence homology with known glucose-6-phosphatase enzymes, which need His, Arg, and negatively charged residues (Asp or Glu) at the active site.	Histidine	99-102	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	57-78
14752623-3	2004	Using either rabbit antibody raised against purified rat liver CDO or against purified recombinant his(6)-tagged CDO (r-his(6)-CDO) and using 15% (wt/vol) polyacrylamide for the SDS-PAGE, we consistently detected the approximately 25 kDa band, but never detected a approximately 68 kDa band, in rat liver, kidney, lung and brain.	Histidine	99-102	cysteine dioxygenase type 1	Rattus norvegicus	113-116
14752623-3	2004	Using either rabbit antibody raised against purified rat liver CDO or against purified recombinant his(6)-tagged CDO (r-his(6)-CDO) and using 15% (wt/vol) polyacrylamide for the SDS-PAGE, we consistently detected the approximately 25 kDa band, but never detected a approximately 68 kDa band, in rat liver, kidney, lung and brain.	Histidine	99-102	cysteine dioxygenase type 1	Rattus norvegicus	113-116
14767880-5	2004	It is now well established that modifying GLP-1 at the N-terminal amino acids, His(7) and Ala(8), can greatly improve resistance to this enzyme.	Histidine	79-82	glucagon like peptide 1 receptor	Homo sapiens	42-47
14719919-0	2004	Hybridization of modified-heme reconstitution and distal histidine mutation to functionalize sperm whale myoglobin.	Histidine	57-66	myoglobin	Physeter catodon	105-114
15323354-2	2004	Analysis of known protein disulphide isomerase and thioredoxin sequences has revealed the presence of conserved Cys, His and Asp residues required for transglutaminases to catalyze the incorporation of primary amines into protein-bound glutamine residues.	Histidine	117-120	prolyl 4-hydroxylase subunit beta	Homo sapiens	18-46
14653956-5	2003	On the other hand, the ameliorating effect of histidine (100 mg/kg, ip) was completely antagonized by alpha-fluoromethylhistidine (alpha-FMH, 5 microg/site, ih), a potent and selective histidine decarboxylase (HDC) inhibitor, and H1-antagonist pyrilamine (1 microg/site, ih), but not by H2-antagonist cimetidine, even at a high dose (2.5 microg/site, ih).	Histidine	46-55	histidine decarboxylase	Rattus norvegicus	185-208
14653956-5	2003	On the other hand, the ameliorating effect of histidine (100 mg/kg, ip) was completely antagonized by alpha-fluoromethylhistidine (alpha-FMH, 5 microg/site, ih), a potent and selective histidine decarboxylase (HDC) inhibitor, and H1-antagonist pyrilamine (1 microg/site, ih), but not by H2-antagonist cimetidine, even at a high dose (2.5 microg/site, ih).	Histidine	46-55	histidine decarboxylase	Rattus norvegicus	210-213
15015733-0	2003	Pradimicin-resistance of yeast is caused by a point mutation of the histidine-containing phosphotransfer protein Ypd1.	Histidine	68-77	Ypd1p	Saccharomyces cerevisiae S288C	113-117
15015733-6	2003	In the reverse turn, glycine (relative position +10 to the active-site histidine) is highly conserved in Ypd1 and other histidine-containing phosphotransfer proteins.	Histidine	71-80	Ypd1p	Saccharomyces cerevisiae S288C	105-109
15015733-6	2003	In the reverse turn, glycine (relative position +10 to the active-site histidine) is highly conserved in Ypd1 and other histidine-containing phosphotransfer proteins.	Histidine	120-129	Ypd1p	Saccharomyces cerevisiae S288C	105-109
12964199-1	2003	The second step in the enzyme-catalyzed hydrolysis of phosphate esters by ribonuclease A (RNase A) was studied using an ab initio quantum-based model of the active site including constrained parts of three critical residues, His-12, His-119, and Lys-41, and a small substrate.	Histidine	225-228	ribonuclease A family member 1, pancreatic	Homo sapiens	74-88
12964199-1	2003	The second step in the enzyme-catalyzed hydrolysis of phosphate esters by ribonuclease A (RNase A) was studied using an ab initio quantum-based model of the active site including constrained parts of three critical residues, His-12, His-119, and Lys-41, and a small substrate.	Histidine	225-228	ribonuclease A family member 1, pancreatic	Homo sapiens	90-97
12964199-1	2003	The second step in the enzyme-catalyzed hydrolysis of phosphate esters by ribonuclease A (RNase A) was studied using an ab initio quantum-based model of the active site including constrained parts of three critical residues, His-12, His-119, and Lys-41, and a small substrate.	Histidine	233-236	ribonuclease A family member 1, pancreatic	Homo sapiens	74-88
12964199-1	2003	The second step in the enzyme-catalyzed hydrolysis of phosphate esters by ribonuclease A (RNase A) was studied using an ab initio quantum-based model of the active site including constrained parts of three critical residues, His-12, His-119, and Lys-41, and a small substrate.	Histidine	233-236	ribonuclease A family member 1, pancreatic	Homo sapiens	90-97
14584938-5	2003	The absence of this COX-2 secondary pocket in the COX-1 binding site is due to the presence of the bulky Ile(523) in COX-1 such that access to the amino acid residues (Ile(517), Phe(518), Gln(192), and His(90)), which line the COX-2 secondary pocket with which the SO(2)Me pharmacophore could interact, is hindered.	Histidine	202-205	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	20-25
12975461-9	2003	Conversely, both the Fc gamma RIIIa 158 valine/valine and the Fc gamma RIIa 131 histidine/histidine genotypes were found to be independently associated with the response rate and freedom from progression.	Histidine	80-89	Fc gamma receptor IIa	Homo sapiens	62-75
12975461-9	2003	Conversely, both the Fc gamma RIIIa 158 valine/valine and the Fc gamma RIIa 131 histidine/histidine genotypes were found to be independently associated with the response rate and freedom from progression.	Histidine	90-99	Fc gamma receptor IIa	Homo sapiens	62-75
14678517-2	2003	In 1996, the human fragile histidine triad gene, FHIT, was identified by positional cloning at 3p14.2, a chromosomal region spanning the carcinogen-sensitive, common fragile site FRA3B.	Histidine	27-36	fragile histidine triad diadenosine triphosphatase	Homo sapiens	179-184
14519125-6	2003	Affinity purification of histidine-tagged eIF3k from transiently transfected COS cells copurifies other eIF3 subunits.	Histidine	25-34	eukaryotic translation initiation factor 3 subunit K	Homo sapiens	42-47
12899615-5	2003	We suggest that the catalytic mechanism of CAD involves a conserved histidine residue, acting as a general base, and another histidine as well as an aspartic acid residue required for cofactor binding.	Histidine	68-77	DNA fragmentation factor subunit beta	Homo sapiens	43-46
12899615-5	2003	We suggest that the catalytic mechanism of CAD involves a conserved histidine residue, acting as a general base, and another histidine as well as an aspartic acid residue required for cofactor binding.	Histidine	125-134	DNA fragmentation factor subunit beta	Homo sapiens	43-46
12867297-4	2003	Using the antibodies and a monoclonal antibody specific to the carboxyl terminal histidine of BNP, a radioimmunoassay for proBNP was constructed.	Histidine	81-90	natriuretic peptide B	Homo sapiens	94-97
12867802-2	2003	Since little is known about the development of this cancer, we searched for alterations to the fragile histidine triad (FHIT) gene, a putative tumour suppressor gene on chromosome 3p14.2.	Histidine	103-112	fragile histidine triad diadenosine triphosphatase	Homo sapiens	120-124
9427740-3	1998	We have performed a systematic survey of conserved histidines in the last six transmembrane segments of the related polytopic membrane proteins PsaA and PsaB in the green alga Chlamydomonas reinhardtii.	Histidine	51-61	photosystem I P700 chlorophyll a apoprotein A1	Chlamydomonas reinhardtii	144-148
9427740-6	1998	Only mutations in the histidines of helix 10 (PsaA-His676 and PsaB-His656) resulted in changes in spectroscopic properties of P700, leading us to conclude that these histidines are most likely the axial ligands to the P700 chlorophylls.	Histidine	22-32	photosystem I P700 chlorophyll a apoprotein A1	Chlamydomonas reinhardtii	46-50
9427740-6	1998	Only mutations in the histidines of helix 10 (PsaA-His676 and PsaB-His656) resulted in changes in spectroscopic properties of P700, leading us to conclude that these histidines are most likely the axial ligands to the P700 chlorophylls.	Histidine	166-176	photosystem I P700 chlorophyll a apoprotein A1	Chlamydomonas reinhardtii	46-50
10063967-1	1998	In early 1996, the Fragile Histidine Triad or FHIT gene (pronounced FIT) was cloned and shown to straddle the most fragile human chromosome site at chromosome band 3p14.2.	Histidine	27-36	fragile histidine triad diadenosine triphosphatase	Homo sapiens	46-50
9442929-4	1997	The plausible role of histidine residues at the active site of brain adenosine deaminase was proved by chemical modification with (DEP).	Histidine	22-31	adenosine deaminase	Bos taurus	69-88
9448095-13	1997	Human liver HMW-ZnAP is sensitive to temperatures higher than 40 degrees C. The pH-dependence of the steady-state kinetic parameters indicates the existence of an essential ionizable group with a pKa of 7.25-7.50, similar to that of histidine.	Histidine	233-242	cilia and flagella associated protein 97	Homo sapiens	12-15
9341195-7	1997	Of the two histidines that compose the type-2 binding site, the His-1957 --&gt; Ala mutant displayed secretion, light and heavy chain assembly, and activity similar to wild-type FVIII, while mutant His-99 --&gt; Ala was partially defective for secretion and had low levels of heavy and light chain association and activity.	Histidine	11-21	coagulation factor VIII	Homo sapiens	178-183
9341195-7	1997	Of the two histidines that compose the type-2 binding site, the His-1957 --&gt; Ala mutant displayed secretion, light and heavy chain assembly, and activity similar to wild-type FVIII, while mutant His-99 --&gt; Ala was partially defective for secretion and had low levels of heavy and light chain association and activity.	Histidine	64-67	coagulation factor VIII	Homo sapiens	178-183
9408001-6	1997	PACAP-27 altered the atrio-His bundle interval but did not alter the His-ventricle interval.	Histidine	27-30	adenylate cyclase activating polypeptide 1	Rattus norvegicus	0-5
9218460-5	1997	The carboxyl-terminal tetrapeptide His-Asp-Glu-Phe was shown to be responsible for retention of calumenin in ER by the retention assay, immunostaining with a confocal laser microscope, and the deglycosylation assay.	Histidine	35-38	calumenin	Mus musculus	96-105
9224937-1	1997	The enzymatic activity of many ribonucleases (RNases) depends on two histidines, as in RNase A, or one histidine and/or glutamate, as in microbial RNases belonging to the T1 family.	Histidine	69-79	ribonuclease A family member 1, pancreatic	Homo sapiens	87-94
9224937-1	1997	The enzymatic activity of many ribonucleases (RNases) depends on two histidines, as in RNase A, or one histidine and/or glutamate, as in microbial RNases belonging to the T1 family.	Histidine	69-78	ribonuclease A family member 1, pancreatic	Homo sapiens	87-94
9266488-18	1997	The other analogs exhibited only a moderate to weak inhibition of furin, suggesting that substitution of all His by aromatic residues (Phe or Tyr) drastically reduces their inhibitory potency.	Histidine	109-112	furin, paired basic amino acid cleaving enzyme	Homo sapiens	66-71
9194196-2	1997	Recombinant human URO-D has been expressed in Escherichia coli with a histidine tag and has been purified to homogeneity.	Histidine	70-79	uroporphyrinogen decarboxylase	Homo sapiens	18-23
9194196-5	1997	URO-D containing an amino-terminal histidine tag was crystallized in space group P3(1)21 or its enantiomer P3(2)21 with unit cell dimensions a = b = 103.6 A, c = 75.2 A.	Histidine	35-44	uroporphyrinogen decarboxylase	Homo sapiens	0-5
9115288-3	1997	Site-directed mutagenesis indicated that a number of residues including arginine 19, cysteine 122, histidine 126, glutamic acid 152, arginine 155, and methionine 167 were needed for protection of SSAT by BE-3-4-3.	Histidine	99-108	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	196-200
9125392-2	1997	The (human) MBP epitope for MS anti-MBP is: Pro85-Val-Val-His-Phe-Phe-Lys-Asn-Ile-Val-Thr-Pro96.	Histidine	58-61	myelin basic protein	Homo sapiens	12-15
9125392-2	1997	The (human) MBP epitope for MS anti-MBP is: Pro85-Val-Val-His-Phe-Phe-Lys-Asn-Ile-Val-Thr-Pro96.	Histidine	58-61	myelin basic protein	Homo sapiens	36-39
9186907-0	1997	Human lysosomal acid lipase/cholesteryl ester hydrolase and human gastric lipase: identification of the catalytically active serine, aspartic acid, and histidine residues.	Histidine	152-161	lipase A, lysosomal acid type	Homo sapiens	6-55
9085937-2	1997	Thus, the mature IFN-alpha2a protein product is characterized by a lysine residue at position 23 (AAA) and a histidine at position 34 (CAA), IFN-alpha2b has an arginine at position 23 (AGA) and histidine at position 34 (CAT), and IFN-alpha2c has arginine residues at both positions 23 (AGA) and 34 (CGT).	Histidine	109-118	interferon alpha 2	Homo sapiens	17-27
9038158-7	1997	Nm23-H1(S120G), found in advanced human neuroblastomas, exhibited deficient activity in several histidine-dependent protein phosphotransfer reactions, including histidine autophosphorylation, downstream phosphorylation on serines, and slightly decreased histidine protein kinase activity; significant NDPK activity was observed.	Histidine	96-105	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	0-4
9038158-7	1997	Nm23-H1(S120G), found in advanced human neuroblastomas, exhibited deficient activity in several histidine-dependent protein phosphotransfer reactions, including histidine autophosphorylation, downstream phosphorylation on serines, and slightly decreased histidine protein kinase activity; significant NDPK activity was observed.	Histidine	161-170	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	0-4
9038158-8	1997	The Nm23-H1(S120A) mutant was deficient in only histidine-dependent serine autophosphorylation.	Histidine	48-57	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	4-11
18475765-1	1997	The interaction of the dinucleotides d(ApG) and d(ApA) with [Pd(aa)Cl(2)], where aa = L- or D-histidine or the methyl ester of L-histidine, and with [Pt(Met)Cl(2)], where Met = L-methionine was studied by (1)H and (13)C NMR and CD measurements.	Histidine	127-138	glutamyl aminopeptidase	Homo sapiens	50-53
18475765-3	1997	The reaction of L-histidine with d(ApA) seemed to form the bimetallic adduct (L-His)PdN7(1)N7(2)Pd(L-His).	Histidine	16-27	glutamyl aminopeptidase	Homo sapiens	35-38
18475765-3	1997	The reaction of L-histidine with d(ApA) seemed to form the bimetallic adduct (L-His)PdN7(1)N7(2)Pd(L-His).	Histidine	78-83	glutamyl aminopeptidase	Homo sapiens	35-38
18475765-3	1997	The reaction of L-histidine with d(ApA) seemed to form the bimetallic adduct (L-His)PdN7(1)N7(2)Pd(L-His).	Histidine	99-104	glutamyl aminopeptidase	Homo sapiens	35-38
9170214-1	1997	The FHIT (fragile histidine triad) gene on chromosome 3p14 is a candidate tumor suppressor gene, and its transcripts are shown to be abnormal in several human cancers.	Histidine	18-27	fragile histidine triad diadenosine triphosphatase	Homo sapiens	4-8
8942668-0	1996	Site-directed mutagenesis of histidine 238 in mouse adenosine deaminase: substitution of histidine 238 does not impede hydroxylate formation.	Histidine	29-38	adenosine deaminase	Mus musculus	52-71
8942668-1	1996	His 238, a conserved amino acid located in hydrogen-bonding distance from C-6 of the substrate in the active site of murine adenosine deaminase (mADA) and postulated to play an important role in catalysis, was altered into an alanine, a glutamate, and an arginine using site-directed mutagenesis.	Histidine	0-3	adenosine deaminase	Mus musculus	124-143
8942668-1	1996	His 238, a conserved amino acid located in hydrogen-bonding distance from C-6 of the substrate in the active site of murine adenosine deaminase (mADA) and postulated to play an important role in catalysis, was altered into an alanine, a glutamate, and an arginine using site-directed mutagenesis.	Histidine	0-3	adenosine deaminase	Mus musculus	145-149
2611263-2	1989	The inactivation of TFIIIA by DEP as detected by an in vitro 5S RNA gene transcription assay was correlated with the extent of modification of histidine residues and Zn2+ release.	Histidine	143-152	general transcription factor 3A L homeolog	Xenopus laevis	20-26
2555360-7	1989	This conclusion is based primarily on comparisons of the spectral properties of the enzyme with those of parallel derivatives of myoglobin (histidine proximal ligand) and P-450 (cysteinate proximal ligand).	Histidine	140-149	myoglobin	Homo sapiens	129-138
2692849-2	1989	The ADE3 locus encodes the trifunctional enzyme C1-tetrahydrofolate synthase, which is required for the biosynthesis of purines, thymidylate, methionine, histidine, pantothenic acid and formylmethionyl-tRNA(fMet.	Histidine	154-163	trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase ADE3	Saccharomyces cerevisiae S288C	4-8
2526198-8	1989	The results demonstrate that CpAse H catalyses the release of C-terminal histidine with great difficulty.	Histidine	73-82	carboxypeptidase E	Homo sapiens	29-36
2499329-2	1989	Glucose-6-phosphate dehydrogenase from the yeast Pichia jadinii has a reactive lysine residue in a segment of amino acid sequence Ile-Asp-His-Tyr-Leu-Gly-Lys*-Glu-Met-Val-Lys.	Histidine	138-141	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	0-33
2930185-3	1989	Of the observable ring protons of the three histidine residues, only the C delta 1H of His46 shows a large chemical shift perturbation on formation of the ternary complex, (nuclease H124L).pdTp.Ca2+.	Histidine	44-53	nuclease	Escherichia coli	173-181
2764952-1	1989	Changes in the circular dichroic and absorption spectra were studied on solutions of myoglobin whose histidine residues had been modified by carboxymethylation under denaturing conditions.	Histidine	101-110	myoglobin	Homo sapiens	85-94
2764952-3	1989	This was accompanied by a remarkable change in the secondary structure of the protein involving helix-to-random coil transition, indicating that extensive histidine modification prevented unfolded myoglobin from refolding to its native conformation.	Histidine	155-164	myoglobin	Homo sapiens	197-206
12890001-4	2003	This nucleotide change causes an amino acid substitution from aspartic acid in DPB1*3901 to histidine at codon 64 in the novel allele.	Histidine	92-101	major histocompatibility complex, class II, DP beta 1	Homo sapiens	79-83
3191138-4	1988	The pH-dependence of KQ1 indicates that the protonation of one amino acid residue (His-GH1 (119] is important for the process.	Histidine	83-86	somatotropin	Physeter catodon	87-90
8960098-1	1996	A polymorphism of the gene for Fc gamma RIIA, arginine (R) or histidine (H) at position 131, alters the ability of the receptor to bind certain IgG subclasses.	Histidine	62-71	Fc gamma receptor IIa	Homo sapiens	31-44
8943007-10	1996	On the basis of the nuclear magnetic resonance data, we propose a structure for the Nup475 metal-binding domain in which the zinc ion is coordinated by the conserved cysteines and histidine, and the conserved YKTEL motif forms a parallel sheet-like structure with the C terminus of this domain.	Histidine	180-189	ZFP36 ring finger protein	Homo sapiens	84-90
8900202-9	1996	Both L-histidine and N-acetyl-L-cysteine showed a significant inhibitory effect on PDT-induced SAPK and p38 HOG1 activation.	Histidine	5-16	mitogen-activated protein kinase 14	Mus musculus	104-107
12777814-2	2003	YPD1, a histidine-containing phosphotransfer (HPt) protein, mediates the transfer of a phosphoryl group between the two response-regulator domains associated with SLN1 and SSK1, the R1 and R2 domains, respectively.	Histidine	8-17	Ypd1p	Saccharomyces cerevisiae S288C	0-4
3372522-5	1988	The hemopexin-SnPP interaction, like that of heme-hemopexin, is dependent on the histidine residues of hemopexin.	Histidine	81-90	hemopexin	Mus musculus	4-13
3372522-5	1988	The hemopexin-SnPP interaction, like that of heme-hemopexin, is dependent on the histidine residues of hemopexin.	Histidine	81-90	hemopexin	Mus musculus	50-59
3372522-5	1988	The hemopexin-SnPP interaction, like that of heme-hemopexin, is dependent on the histidine residues of hemopexin.	Histidine	81-90	hemopexin	Mus musculus	50-59
12777814-2	2003	YPD1, a histidine-containing phosphotransfer (HPt) protein, mediates the transfer of a phosphoryl group between the two response-regulator domains associated with SLN1 and SSK1, the R1 and R2 domains, respectively.	Histidine	8-17	histidine kinase	Saccharomyces cerevisiae S288C	163-167
12926121-1	2003	BACKGROUND: The fragile histidine triad (FHIT) gene is a candidate tumor suppressor gene located at 3p14.2, and the absence or reduction of Fhit protein expression has recently been reported in various carcinomas.	Histidine	24-33	fragile histidine triad diadenosine triphosphatase	Homo sapiens	41-45
3410637-4	1988	The pK2 of His-12 was not affected by the interaction of the enzyme with these ligands, whereas, the perturbation of the pK2 of His-119 was clearly dependent on the nature of the ligand.	Histidine	11-14	prokineticin 2	Bos taurus	4-7
3410637-4	1988	The pK2 of His-12 was not affected by the interaction of the enzyme with these ligands, whereas, the perturbation of the pK2 of His-119 was clearly dependent on the nature of the ligand.	Histidine	128-131	prokineticin 2	Bos taurus	121-124
8849681-2	1996	Residues that are conserved in ORL1 and the three types of opioid receptor, but also a residue, His in the sixth putative transmembrane (TM6) helix, which is present in all opioid receptor types but absent in ORL1, appear to play a key role in receptor recognition and/or activation.	Histidine	96-99	opioid related nociceptin receptor 1	Homo sapiens	31-35
8849681-2	1996	Residues that are conserved in ORL1 and the three types of opioid receptor, but also a residue, His in the sixth putative transmembrane (TM6) helix, which is present in all opioid receptor types but absent in ORL1, appear to play a key role in receptor recognition and/or activation.	Histidine	96-99	opioid related nociceptin receptor 1	Homo sapiens	209-213
12724542-8	2003	WAX2 has six transmembrane domains, a His-rich diiron binding region at the N-terminal region, and a large soluble C-terminal domain.	Histidine	38-41	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	0-4
8849681-3	1996	Here we have sought to create an opioid binding pocket in the non-opioid ORL1 receptor by replacing residue Gln280 in its TM6 by the corresponding His residue of opioid receptors.	Histidine	147-150	opioid related nociceptin receptor 1	Homo sapiens	73-77
8849681-7	1996	The mutation Q280H, which increases affinity while decreasing intrinsic activity of opioids at ORL1, emphasizes the importance of the His residue for opioid recognition and activation.	Histidine	134-137	opioid related nociceptin receptor 1	Homo sapiens	95-99
8828480-6	1996	PTH and PTHrP differ in several positions, including position 5 (Ile in PTH; His in PTHrP).	Histidine	77-80	parathyroid hormone like hormone	Homo sapiens	8-13
8828480-6	1996	PTH and PTHrP differ in several positions, including position 5 (Ile in PTH; His in PTHrP).	Histidine	77-80	parathyroid hormone like hormone	Homo sapiens	84-89
2452199-9	1988	Monoclonal IgM RF which bound best to histidine-modified IgG also bound well to IgG3.	Histidine	38-47	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	80-84
12744737-1	2003	FHIT (fragile histidine triad) gene at chromosome 3p14.2 usually expresses at a very low level in human tissue and cells.	Histidine	14-23	fragile histidine triad diadenosine triphosphatase	Homo sapiens	0-4
3287426-0	1988	Ergothioneine, histidine, and two naturally occurring histidine dipeptides as radioprotectors against gamma-irradiation inactivation of bacteriophages T4 and P22.	Histidine	54-63	calcineurin like EF-hand protein 1	Homo sapiens	158-161
21153111-7	1996	However, some ubiquitin residues known to function in the ligation (Arg-54) to targeted proteins and in the processing of conjugates through the proteasome (His-68), have been lost through mutation in bUCRP.	Histidine	157-160	ubiquitin	Bos taurus	14-23
8816462-14	1996	Mutations in the cysteine- and histidine-rich region of Upf1p abolish Upf1p-Upf2p interaction.	Histidine	31-40	Nmd2p	Saccharomyces cerevisiae S288C	76-81
8848048-5	1996	Binding occurs between the first cysteine-histidine-rich region of p300/CBP and the carboxy-terminal segment of Stat2, a domain essential for ISGF3 function.	Histidine	42-51	E1A binding protein p300	Homo sapiens	67-75
3240339-1	1988	In order to study biosynthetic processing of preprovasoactive intestinal peptide (prepro VIP) we have raised antisera to sequences that flank the biologically active peptides VIP and PHI (peptide with N-terminal His and C-terminal Ile).	Histidine	212-215	glucose-6-phosphate isomerase	Rattus norvegicus	183-186
12651009-6	2003	The purification of MnSOD was performed by chromatography applying the His-tag technology.	Histidine	71-74	superoxide dismutase 2	Homo sapiens	20-25
8816823-5	1996	Tunicate GnRH-I (pGlu-His-Trp-Ser-Asp-Tyr-Phe-Lys-Pro-Gly-NH2) has 60% of its residues conserved, compared with mammalian GnRH, whereas tunicate GnRH-II (pGlu-His-Trp-Ser-Leu-Cys-His-Ala-Pro-Gly-NH2) is unusual in that it was isolated as a disulfide-linked dimer.	Histidine	22-25	gonadotropin releasing hormone 1	Homo sapiens	9-13
12646236-4	2003	In contrast, mMCP-4 hydrolyzed Ang I at two sites, Tyr(4)-Ile(5) and Phe(8)-His(9), with Ang II formation being tentative.	Histidine	76-79	mast cell protease 4	Mus musculus	13-19
8816823-5	1996	Tunicate GnRH-I (pGlu-His-Trp-Ser-Asp-Tyr-Phe-Lys-Pro-Gly-NH2) has 60% of its residues conserved, compared with mammalian GnRH, whereas tunicate GnRH-II (pGlu-His-Trp-Ser-Leu-Cys-His-Ala-Pro-Gly-NH2) is unusual in that it was isolated as a disulfide-linked dimer.	Histidine	22-25	gonadotropin releasing hormone 2	Homo sapiens	145-152
8816823-5	1996	Tunicate GnRH-I (pGlu-His-Trp-Ser-Asp-Tyr-Phe-Lys-Pro-Gly-NH2) has 60% of its residues conserved, compared with mammalian GnRH, whereas tunicate GnRH-II (pGlu-His-Trp-Ser-Leu-Cys-His-Ala-Pro-Gly-NH2) is unusual in that it was isolated as a disulfide-linked dimer.	Histidine	159-162	gonadotropin releasing hormone 1	Homo sapiens	9-13
8816823-5	1996	Tunicate GnRH-I (pGlu-His-Trp-Ser-Asp-Tyr-Phe-Lys-Pro-Gly-NH2) has 60% of its residues conserved, compared with mammalian GnRH, whereas tunicate GnRH-II (pGlu-His-Trp-Ser-Leu-Cys-His-Ala-Pro-Gly-NH2) is unusual in that it was isolated as a disulfide-linked dimer.	Histidine	159-162	gonadotropin releasing hormone 1	Homo sapiens	9-13
2454175-9	1988	The Asp in C4-A and His in C4-B seem likely to be the major specificity-defining residues.	Histidine	20-23	complement component 4B (Chido blood group)	Mus musculus	27-31
12627509-1	2003	BACKGROUND: The fragile histidine triad (FHIT) gene is a tumor suppressor gene that belongs to the histidine triad family of nucleoside binding proteins.	Histidine	24-33	fragile histidine triad diadenosine triphosphatase	Homo sapiens	41-45
2962936-5	1988	Tyrosine and histidine were observed in a ratio of 2:1, respectively, and therefore this polymorphism is likely to represent a sequence difference between the two most abundant charge variants, FH1 and FH2, of factor H.	Histidine	13-22	filamin B	Homo sapiens	194-197
12649173-0	2003	Restoration of fragile histidine triad (FHIT) expression induces apoptosis and suppresses tumorigenicity in breast cancer cell lines.	Histidine	23-32	fragile histidine triad diadenosine triphosphatase	Homo sapiens	40-44
3227014-4	1988	These are Ser 103 and Leu 155 in gamma-II, which are replaced by Met 103 and His 155 in gamma-IIb.	Histidine	77-80	G protein subunit gamma 7	Bos taurus	33-41
3427072-2	1987	The first histidine in this sequence in the tyrosyl-tRNA synthetase, His-45, has been shown to form part of a binding site for the gamma-phosphate of ATP in the transition state for the reaction as does Thr-40.	Histidine	10-19	tyrosyl-tRNA synthetase 1	Homo sapiens	44-67
3427072-2	1987	The first histidine in this sequence in the tyrosyl-tRNA synthetase, His-45, has been shown to form part of a binding site for the gamma-phosphate of ATP in the transition state for the reaction as does Thr-40.	Histidine	69-72	tyrosyl-tRNA synthetase 1	Homo sapiens	44-67
8798433-4	1996	The murine Cux-2 homeobox was similar to Drosophila cut and encoded a homeodomain that contained a characteristic histidine residue at position 50.	Histidine	114-123	cut	Drosophila melanogaster	52-55
8794732-6	1996	Site-directed mutagenesis of FHIT demonstrated that all four conserved histidines are required for full activity, and the central histidine of the triad is absolutely essential for Ap3A hydrolase activity.	Histidine	71-81	fragile histidine triad diadenosine triphosphatase	Homo sapiens	29-33
8794732-6	1996	Site-directed mutagenesis of FHIT demonstrated that all four conserved histidines are required for full activity, and the central histidine of the triad is absolutely essential for Ap3A hydrolase activity.	Histidine	71-80	fragile histidine triad diadenosine triphosphatase	Homo sapiens	29-33
8794732-8	1996	Also, Fhit is the first HIT protein in which the histidine residues have been demonstrated by mutagenesis to be critical for function.	Histidine	49-58	fragile histidine triad diadenosine triphosphatase	Homo sapiens	6-10
8841413-4	1996	Substitution of the His or Lys residues with Ala in the IF1-(42-58)-peptide decreased the inhibition of ATP hydrolysis.	Histidine	20-23	ATP synthase inhibitory factor subunit 1	Bos taurus	56-59
8760503-8	1996	(1) A highly conserved histidine residue in the first complementarity-determining region of the TcR beta chain (beta:CDR1) points outward and interacts with highly conserved side-chains on the MHC alpha 2 helix.	Histidine	23-32	cerebellar degeneration related antigen 1	Mus musculus	112-121
8774702-6	1996	Glu103, and two histidine residues at positions 37 and 200 in human recombinant eIF-4E were suggested to be important for the recognition of the mRNA cap structure through direct interaction and/or indirect contributions.	Histidine	16-25	eukaryotic translation initiation factor 4E	Homo sapiens	80-86
8672465-8	1996	One interaction is between the aromatic ring of Tyr 282 of TM-6 and His of TRH.	Histidine	68-71	thyrotropin releasing hormone	Homo sapiens	75-78
8649348-1	1996	Thyrotropin-releasing hormone (TRH) is a tripeptide (&lt; Glu-His-Pro-NH2) that signals through a G protein-coupled receptor.	Histidine	62-65	thyrotropin releasing hormone	Homo sapiens	0-29
8649348-1	1996	Thyrotropin-releasing hormone (TRH) is a tripeptide (&lt; Glu-His-Pro-NH2) that signals through a G protein-coupled receptor.	Histidine	62-65	thyrotropin releasing hormone	Homo sapiens	31-34
8639621-3	1996	The protein shares 40% identity with yeast bleomycin hydrolase and contains the conserved active site residues (Cys, His, Asn) characteristic for cysteine proteases of the papain superfamily.	Histidine	117-120	bleomycin hydrolase	Saccharomyces cerevisiae S288C	43-62
8634235-1	1996	Histidinol dehydrogenase (HDH), a dimeric protein, catalyzes two sequential oxidation reactions to yield L-histidine from L-histidinol via L-histidinal.	Histidine	105-116	histidinol dehydrogenase, chloroplastic	Brassica oleracea	0-24
8634235-1	1996	Histidinol dehydrogenase (HDH), a dimeric protein, catalyzes two sequential oxidation reactions to yield L-histidine from L-histidinol via L-histidinal.	Histidine	105-116	histidinol dehydrogenase, chloroplastic	Brassica oleracea	26-29
8634235-6	1996	113Cd NMR spectra of [113Cd]HDH were measured as complexes with two substrates (L-histidinol and DL-histidinal) and four inhibitors (imidazole, histamine, L-histidine, and DL-4-(4-imidazolyl)-3-amino-2-butanone) in the absence and presence of NAD+.	Histidine	155-166	histidinol dehydrogenase, chloroplastic	Brassica oleracea	28-31
8928792-1	1996	The enzyme L-histidine decarboxylase (HDC; EC 4.1.1.22), which converts L-histidine to histamine, plays a key role in the regulation of acid secretion.	Histidine	11-22	histidine decarboxylase	Rattus norvegicus	38-41
8967341-3	1996	JNK1 (p45) and JNK2 (p54) isoforms phosphorylated His-c-jun in mesangial cells.	Histidine	50-53	interferon induced protein with tetratricopeptide repeats 2	Homo sapiens	21-24
8639516-10	1996	In conclusion, our studies suggest that the unique histidine residues H90 and H109 in B. subtilis PPIase are, at least in part, responsible for its intermediate CsA affinity and that the v52 residue confers the low conversion rate.	Histidine	51-60	peptidylprolyl isomerase like 3	Homo sapiens	98-104
8838085-2	1996	L-Histidine decarboxylase (HDC) is a unique enzyme in mammals which catalyzes histamine formation from L-histidine.	Histidine	103-114	histidine decarboxylase	Homo sapiens	0-25
8838085-2	1996	L-Histidine decarboxylase (HDC) is a unique enzyme in mammals which catalyzes histamine formation from L-histidine.	Histidine	103-114	histidine decarboxylase	Homo sapiens	27-30
8546716-9	1996	These data describe a potential alternative mechanism for the activation of GTP-binding proteins in beta cells which contrasts with the classical receptor-agonist mechanism: G beta undergoes transient phosphorylation at a histidine residue by a GTP-specific protein kinase; this phosphate, in turn, may be transferred via a classical Ping-Pong mechanism to G alpha.GDP (inactive), yielding the active configuration G alpha.GTP in secretory granules (a strategic location to modulate exocytosis).	Histidine	222-231	succinate-CoA ligase GDP-forming subunit beta	Homo sapiens	174-180
7594568-4	1995	An abundance of histidine residues in the first extracellular domain of KIR, including the signature zinc binding motif HEXXH, suggested that this receptor may bind zinc.	Histidine	16-25	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	72-75
8596196-6	1995	Histidine significantly enhanced ecto-5"-nucleotidase activity (6.55 +/- 0.52 mumol/min/g dry weight, P &lt; 0.05 v ischemic control).	Histidine	0-9	5' nucleotidase, ecto	Rattus norvegicus	33-53
8819982-1	1995	Two mutant forms of human glutathione transferase (GST) A1-1 with affinity for metal ions were constructed by introduction of His residues by site-directed mutagenesis.	Histidine	126-129	glutathione S-transferase alpha 1	Homo sapiens	26-60
7608199-1	1995	Three amino acid transporter genes (AAP3-5) were isolated from Arabidopsis by complementation of a yeast mutant defective in histidine uptake.	Histidine	125-134	amino acid permease 3	Arabidopsis thaliana	36-42
7543292-8	1995	However, detection of a single-stranded conformation polymorphism (SSCP) allowed the identification of a single C to G substitution (His to Gln) in the dck cDNA of the DAC-resistant RD/1 clone.	Histidine	133-136	deoxycytidine kinase	Rattus norvegicus	152-155
7633464-9	1995	The isolated clone encodes the highly conserved active site residues (His, Asp, Ser) and specificity pocket residues present in bovine chymotrypsinogen B.	Histidine	70-73	chymotrypsinogen B	Bos taurus	135-153
7671010-2	1995	The SH3 (src homolog type 3) domain of yeast Cdc25p, fused both to a tail of 6 histidine (His) and to glutathione-S-transferase (GST), was purified and then, using His affinity for Ni2+ ions, bound to a Ni-NTA column.	Histidine	79-88	Ras family guanine nucleotide exchange factor CDC25	Saccharomyces cerevisiae S288C	45-51
7671010-2	1995	The SH3 (src homolog type 3) domain of yeast Cdc25p, fused both to a tail of 6 histidine (His) and to glutathione-S-transferase (GST), was purified and then, using His affinity for Ni2+ ions, bound to a Ni-NTA column.	Histidine	90-93	Ras family guanine nucleotide exchange factor CDC25	Saccharomyces cerevisiae S288C	45-51
7667069-6	1995	When an extracellular histidine at position 401 of Kv1.3 is replaced with tyrosine, the residue at the equivalent position (430) in Kv1.6, the resulting Kv1.3 H401Y mutant channel does not undergo the on-cell/off-cell change.	Histidine	22-31	potassium channel, voltage gated shaker related subfamily A, member 3 S homeolog	Xenopus laevis	51-56
7667069-6	1995	When an extracellular histidine at position 401 of Kv1.3 is replaced with tyrosine, the residue at the equivalent position (430) in Kv1.6, the resulting Kv1.3 H401Y mutant channel does not undergo the on-cell/off-cell change.	Histidine	22-31	potassium channel, voltage gated shaker related subfamily A, member 3 S homeolog	Xenopus laevis	153-158
7713895-2	1995	Our results are consistent with the involvement of Asp-333 and His-523 in a catalytic mechanism similar to that of other alpha/beta hydrolase fold enzymes.	Histidine	63-66	abhydrolase domain containing 15	Mus musculus	121-141
7744028-4	1995	The weak affinity of CyP-40 for cyclosporin A was postulated to arise from a histidine residue that replaces a tryptophan residue critical for cyclosporin A binding and highly conserved in other cyclophilins that have high affinity for cyclosporin A.	Histidine	77-86	peptidylprolyl isomerase D	Homo sapiens	21-27
7757200-7	1995	Dihydrolipoamide, dihydrolipoic acid, Captopril, acetylcysteine, EDTA, DETAPAC, histidine, bathocuproine, GSSG and trypanothione prevented LADH inactivation.	Histidine	80-89	dihydrolipoamide dehydrogenase	Sus scrofa	139-143
7761629-7	1995	The amino acid sequence of sturgeon GnRH is pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2.	Histidine	49-52	gonadotropin releasing hormone 1	Homo sapiens	36-40
8830494-9	1995	The putative ORF3 product which had been tagged by a 6 Histidine tail, was expressed in E. coli and purified by nickel chelate affinity chromatography before 2-dimensional polyacrylamide gel electrophoresis and immunostaining with a rabbit anti-peptide serum directed against the N-terminus of the ORF3 product.	Histidine	55-64	hypothetical protein	Escherichia coli	13-17
7869829-1	1995	The aim of our study was to investigate the effects of His-DTrp-Ala-Trp-Phe-Lys-NH2 (GHRP-6) on baseline and growth hormone-releasing hormone (GHRH) stimulated growth hormone (GH) release in conscious, freely-moving rats receiving chronic glucocorticoid treatment.	Histidine	55-58	growth hormone releasing hormone	Rattus norvegicus	109-141
7869829-1	1995	The aim of our study was to investigate the effects of His-DTrp-Ala-Trp-Phe-Lys-NH2 (GHRP-6) on baseline and growth hormone-releasing hormone (GHRH) stimulated growth hormone (GH) release in conscious, freely-moving rats receiving chronic glucocorticoid treatment.	Histidine	55-58	growth hormone releasing hormone	Rattus norvegicus	143-147
7869829-1	1995	The aim of our study was to investigate the effects of His-DTrp-Ala-Trp-Phe-Lys-NH2 (GHRP-6) on baseline and growth hormone-releasing hormone (GHRH) stimulated growth hormone (GH) release in conscious, freely-moving rats receiving chronic glucocorticoid treatment.	Histidine	55-58	gonadotropin releasing hormone receptor	Rattus norvegicus	109-123
7869829-1	1995	The aim of our study was to investigate the effects of His-DTrp-Ala-Trp-Phe-Lys-NH2 (GHRP-6) on baseline and growth hormone-releasing hormone (GHRH) stimulated growth hormone (GH) release in conscious, freely-moving rats receiving chronic glucocorticoid treatment.	Histidine	55-58	gonadotropin releasing hormone receptor	Rattus norvegicus	85-87
7821797-1	1994	The Tat protein of equine infectious anemia virus (EIAV) was synthesized in Escherichia coli using the inducible expression plasmid, pET16b, which contains a His.Tag leader, thus allowing for rapid and efficient enrichment of the histidine-tagged protein by metal affinity chromatography.	Histidine	158-161	tyrosine aminotransferase	Homo sapiens	4-7
8556514-2	1994	We investigated the His-Arg (CAT/CGT) polymorphism at codon 131 of the Fc gamma receptor IIA gene, which influences ligand binding by the receptor.	Histidine	20-23	Fc gamma receptor IIa	Homo sapiens	71-92
7929349-2	1994	The structural basis of the multiple ligand specificity of the periplasmic lysine-, arginine-, ornithine-binding protein (LAO) was investigated by determining and analyzing the structures of the protein unliganded and liganded with each of the three high-affinity ligands (L-lysine, L-arginine, and L-ornithine) and with one low-affinity ligand (L-histidine).	Histidine	346-357	interleukin 4 induced 1	Homo sapiens	75-120
7929349-2	1994	The structural basis of the multiple ligand specificity of the periplasmic lysine-, arginine-, ornithine-binding protein (LAO) was investigated by determining and analyzing the structures of the protein unliganded and liganded with each of the three high-affinity ligands (L-lysine, L-arginine, and L-ornithine) and with one low-affinity ligand (L-histidine).	Histidine	346-357	interleukin 4 induced 1	Homo sapiens	122-125
7929349-5	1994	The structure of the LAO-histidine complex indicates that the 30-fold reduced affinity of the protein for histidine is primarily due to unavailability of one ionic interaction of the histidine side chain with the protein which is present in the other three complexes.	Histidine	25-34	interleukin 4 induced 1	Homo sapiens	21-24
7929349-5	1994	The structure of the LAO-histidine complex indicates that the 30-fold reduced affinity of the protein for histidine is primarily due to unavailability of one ionic interaction of the histidine side chain with the protein which is present in the other three complexes.	Histidine	106-115	interleukin 4 induced 1	Homo sapiens	21-24
7929349-5	1994	The structure of the LAO-histidine complex indicates that the 30-fold reduced affinity of the protein for histidine is primarily due to unavailability of one ionic interaction of the histidine side chain with the protein which is present in the other three complexes.	Histidine	106-115	interleukin 4 induced 1	Homo sapiens	21-24
7702747-3	1994	Comparison of the predicted model and crystal structure shows that the active-site histidine residues and the core of the angiogenin molecule, including most of the beta-strands and alpha-helices, were predicted reasonably well.	Histidine	83-92	angiogenin	Homo sapiens	122-132
7916381-7	1994	Native pre-beta-lactamase could be stabilized by lowering the pH value from 7.0 to 5.5, probably by protonating a histidine residue leading to an improved solubility of the signal sequence.	Histidine	114-123	beta-lactamase	Escherichia coli	11-25
8037463-1	1994	Cabbage histidinol dehydrogenase (HDH) oxidizes L-histidinol to L-histidine through two sequential NAD(+)-linked reactions via an alkaline-labile, L-histidinaldehyde intermediate.	Histidine	64-75	histidinol dehydrogenase, chloroplastic	Brassica oleracea	34-37
8037463-10	1994	The overall oxidation from histidinol to histidine proceeded about three times slower than the partial oxidation from histidinaldehyde to histidine, suggesting that the first-half forward reaction is the rate-determining step in the total reaction of cabbage HDH.	Histidine	41-50	histidinol dehydrogenase, chloroplastic	Brassica oleracea	259-262
8037463-10	1994	The overall oxidation from histidinol to histidine proceeded about three times slower than the partial oxidation from histidinaldehyde to histidine, suggesting that the first-half forward reaction is the rate-determining step in the total reaction of cabbage HDH.	Histidine	138-147	histidinol dehydrogenase, chloroplastic	Brassica oleracea	259-262
8046255-2	1994	The method, requiring PCR amplification of genomic DNA and Southern analysis with allele specific oligonucleotide probes, detects a single nucleotide difference (G or A) at base 494 which results in an arginine (R) or histidine (H) at amino acid 131 of the Fc gamma RIIA protein.	Histidine	218-227	Fc gamma receptor IIa	Homo sapiens	257-270
7920712-1	1994	Complete DNA sequences encoding the Arabidopsis thaliana STP1 monosaccharide/H+ symporter or a histidine-tagged STP1-His6 protein were expressed in baker"s yeast Saccharomyces cerevisiae.	Histidine	95-104	1-(5-phosphoribosyl)-5- ((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase HIS6	Saccharomyces cerevisiae S288C	117-121
8016074-0	1994	Molecular basis of a null mutation in soybean lipoxygenase 2: substitution of glutamine for an iron-ligand histidine.	Histidine	107-116	seed linoleate 9S-lipoxygenase-2	Glycine max	46-60
8016074-6	1994	It is known that His-504 in soybean lipoxygenase 1, which corresponds to His-532 in lipoxygenase 2, is one of the iron-binding ligands essential for lipoxygenase activity.	Histidine	17-20	seed linoleate 9S-lipoxygenase-2	Glycine max	84-98
8016074-6	1994	It is known that His-504 in soybean lipoxygenase 1, which corresponds to His-532 in lipoxygenase 2, is one of the iron-binding ligands essential for lipoxygenase activity.	Histidine	73-76	seed linoleate 9S-lipoxygenase-2	Glycine max	84-98
8201622-5	1994	A naturally occurring variant of beta 1 alcohol dehydrogenase, found in approximately 50% of the Asian population, possesses a His at position 47 (beta 2 or beta 47H) and was crystallized in a complex with NAD+ and the inhibitor 4-iodopyrazole.	Histidine	127-130	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	147-153
8054481-0	1994	Production and structural characterization of amino terminally histidine tagged human oncostatin M in E. coli.	Histidine	63-72	oncostatin M	Homo sapiens	86-98
7523245-4	1994	p300 contains three cysteine- and histidine-rich regions of which the most carboxy-terminal region interacts specifically with E1A.	Histidine	34-43	E1A binding protein p300	Homo sapiens	0-4
8194104-1	1994	The mechanism of action of His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 (GHRP-6), a synthetic peptide which specifically induces the secretion of growth hormone (GH) in rat somatotrophs, is still poorly understood.	Histidine	27-30	gonadotropin releasing hormone receptor	Rattus norvegicus	133-147
8194104-1	1994	The mechanism of action of His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 (GHRP-6), a synthetic peptide which specifically induces the secretion of growth hormone (GH) in rat somatotrophs, is still poorly understood.	Histidine	27-30	gonadotropin releasing hormone receptor	Rattus norvegicus	60-62
8106349-3	1994	The results confirm that ODC activity requires the formation of a dimer and that this dimer contains two active sites, each made up from part of one subunit that contains amino acids lysine 69, lysine 169, and histidine 197 and a part of the other subunit that contains cysteine 360.	Histidine	210-219	ornithine decarboxylase 1	Homo sapiens	25-28
8307321-5	1993	A recessive RRol mutation of rol-6 is a replacement of one of the same conserved arginines by histidine.	Histidine	94-103	Cuticle collagen rol-6	Caenorhabditis elegans	29-34
8138543-1	1993	Histidinol dehydrogenase (HDH) catalyzes two sequential oxidation reactions to produce histidine from histidinol via histidinaldehyde.	Histidine	87-96	histidinol dehydrogenase, chloroplastic	Brassica oleracea	26-29
8138543-6	1993	All the Cys-112 mutant HDHs catalyzed both the alcohol dehydrogenase and aldehyde dehydrogenase reactions, producing 1 mol of L-histidine during the reduction of 2 mol of NAD+, as did the wild type HDH.	Histidine	126-137	histidinol dehydrogenase, chloroplastic	Brassica oleracea	23-26
8230194-0	1993	High-resolution crystal structures of distal histidine mutants of sperm whale myoglobin.	Histidine	45-54	myoglobin	Physeter catodon	78-87
8230194-1	1993	The highly conserved distal histidine residue (His64) of sperm whale myoglobin modulates the affinity of ligands.	Histidine	28-37	myoglobin	Physeter catodon	69-78
7691185-1	1993	Substitution of Asn, Ala or His for Asp-116 in angiogenin increases its ribonucleolytic activity towards tRNA and, at least in the case of His, its ability to induce blood-vessel formation (Harper, J.W.	Histidine	28-31	angiogenin	Homo sapiens	47-57
7691185-13	1993	The results demonstrate that the principal effect of replacing Asp-116 in angiogenin is to modulate enzymatic activity, possibly through an effect on His-114, and suggest that Asp-116 plays a role in controlling specificity.	Histidine	150-153	angiogenin	Homo sapiens	74-84
3624221-5	1987	The 1H and 13C nuclear magnetic resonance data indicated that imidazole C-2 of histidine is linked to C-6 of norleucine (epsilon-deaminated lysine residue) which in turn is linked to the C-6 amino group of hydroxylysine.	Histidine	79-88	complement C6	Bos taurus	102-105
3624221-5	1987	The 1H and 13C nuclear magnetic resonance data indicated that imidazole C-2 of histidine is linked to C-6 of norleucine (epsilon-deaminated lysine residue) which in turn is linked to the C-6 amino group of hydroxylysine.	Histidine	79-88	complement C6	Bos taurus	187-190
2440383-3	1987	Zn2+-induced precipitation of alpha 2M-CH3NH2 or alpha 2M-trypsin is prevented by acylation of the protein employing the histidine-specific reagent diethylpyrocarbonate (DEP).	Histidine	121-130	alpha-2-macroglobulin	Homo sapiens	30-38
2440383-3	1987	Zn2+-induced precipitation of alpha 2M-CH3NH2 or alpha 2M-trypsin is prevented by acylation of the protein employing the histidine-specific reagent diethylpyrocarbonate (DEP).	Histidine	121-130	alpha-2-macroglobulin	Homo sapiens	49-57
3036144-3	1987	The NO-ferrous cytochrome c" would be a mixture of NO complexes with six- and five-coordinate nitrosylheme, suggesting that the heme-iron to histidine bond in the ferrous cytochrome c" is more stable than that from chemoheterotrophic bacteria.	Histidine	141-150	cytochrome c, somatic	Equus caballus	15-27
3036144-3	1987	The NO-ferrous cytochrome c" would be a mixture of NO complexes with six- and five-coordinate nitrosylheme, suggesting that the heme-iron to histidine bond in the ferrous cytochrome c" is more stable than that from chemoheterotrophic bacteria.	Histidine	141-150	cytochrome c, somatic	Equus caballus	171-183
2821278-1	1987	A re-examination of the C-2 histidine proton resonances of haemoglobins A and Cowtown (His HC3(146) beta----Leu) in chloride-free Hepes buffer has shown that all the resonances present in haemoglobin A are present in haemoglobin Cowtown, so that the pKa of His HC3(146) beta cannot be determined by nuclear magnetic resonance in this buffer.	Histidine	28-37	complement C2	Homo sapiens	24-27
3030432-5	1987	The function of the heme c moieties in the catalytic cycle of the enzyme is discussed on the basis of their homology with the proximal histidine region of peroxidase (horseradish peroxidase and yeast cytochrome-c peroxidase) and cytochromes (horse cytochrome c and Pseudomonas cytochrome c-551).	Histidine	135-144	cytochrome c, somatic	Equus caballus	248-260
3030432-5	1987	The function of the heme c moieties in the catalytic cycle of the enzyme is discussed on the basis of their homology with the proximal histidine region of peroxidase (horseradish peroxidase and yeast cytochrome-c peroxidase) and cytochromes (horse cytochrome c and Pseudomonas cytochrome c-551).	Histidine	135-144	cytochrome c, somatic	Equus caballus	277-289
3548429-1	1987	Less than Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2, the luteinizing hormone-releasing hormone, LHRH, is degraded in renal proximal tubules (PT) in vivo (rat) and in vitro (rabbit) to less than Glu-His (2), less than Glu-His-Trp (3), and less than Glu-His-Trp-Ser (4).	Histidine	14-17	gonadotropin releasing hormone 1	Rattus norvegicus	98-102
3548429-1	1987	Less than Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2, the luteinizing hormone-releasing hormone, LHRH, is degraded in renal proximal tubules (PT) in vivo (rat) and in vitro (rabbit) to less than Glu-His (2), less than Glu-His-Trp (3), and less than Glu-His-Trp-Ser (4).	Histidine	200-203	gonadotropin releasing hormone 1	Rattus norvegicus	59-96
3548429-1	1987	Less than Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2, the luteinizing hormone-releasing hormone, LHRH, is degraded in renal proximal tubules (PT) in vivo (rat) and in vitro (rabbit) to less than Glu-His (2), less than Glu-His-Trp (3), and less than Glu-His-Trp-Ser (4).	Histidine	200-203	gonadotropin releasing hormone 1	Rattus norvegicus	98-102
3548429-1	1987	Less than Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2, the luteinizing hormone-releasing hormone, LHRH, is degraded in renal proximal tubules (PT) in vivo (rat) and in vitro (rabbit) to less than Glu-His (2), less than Glu-His-Trp (3), and less than Glu-His-Trp-Ser (4).	Histidine	200-203	gonadotropin releasing hormone 1	Rattus norvegicus	59-96
3548429-1	1987	Less than Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2, the luteinizing hormone-releasing hormone, LHRH, is degraded in renal proximal tubules (PT) in vivo (rat) and in vitro (rabbit) to less than Glu-His (2), less than Glu-His-Trp (3), and less than Glu-His-Trp-Ser (4).	Histidine	200-203	gonadotropin releasing hormone 1	Rattus norvegicus	98-102
3548429-1	1987	Less than Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2, the luteinizing hormone-releasing hormone, LHRH, is degraded in renal proximal tubules (PT) in vivo (rat) and in vitro (rabbit) to less than Glu-His (2), less than Glu-His-Trp (3), and less than Glu-His-Trp-Ser (4).	Histidine	200-203	gonadotropin releasing hormone 1	Rattus norvegicus	59-96
3548429-1	1987	Less than Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2, the luteinizing hormone-releasing hormone, LHRH, is degraded in renal proximal tubules (PT) in vivo (rat) and in vitro (rabbit) to less than Glu-His (2), less than Glu-His-Trp (3), and less than Glu-His-Trp-Ser (4).	Histidine	200-203	gonadotropin releasing hormone 1	Rattus norvegicus	98-102
3548429-4	1987	[D-Ser4]LHRH was not cleaved at D Ser4-Tyr5 but yielded less than Glu-His-Trp-D-Ser-Tyr-Gly as the major metabolite plus 2 and 3.	Histidine	70-73	gonadotropin releasing hormone 1	Rattus norvegicus	8-12
3548429-8	1987	[3H]LHRH was cleaved by BBM or by endopeptidase-24.11 from porcine PT to metabolites 2, 4, small amounts of 3, and less than Glu-His-Trp-Ser-Tyr-Gly, but cleavage was strongly inhibited by the specific inhibitor phosphoramidon.	Histidine	129-132	gonadotropin releasing hormone 1	Rattus norvegicus	4-8
2947813-3	1986	Three different point mutants in a unique histidine residue (position 30) exhibited varying degrees of reduced IL-1 receptor binding affinity, whereas point mutants at five other residues behaved normally.	Histidine	42-51	interleukin 1 alpha	Homo sapiens	111-115
2947813-5	1986	These data suggest that the unique histidine residue influences the architecture of the receptor binding site on human IL-1.	Histidine	35-44	interleukin 1 alpha	Homo sapiens	119-123
3540940-7	1986	Cytochrome b5 is normally a six-coordinate low spin heme protein with histidine-39 and histidine-63 as axial ligands.	Histidine	70-79	cytochrome b5 type A	Homo sapiens	0-13
3540940-7	1986	Cytochrome b5 is normally a six-coordinate low spin heme protein with histidine-39 and histidine-63 as axial ligands.	Histidine	87-96	cytochrome b5 type A	Homo sapiens	0-13
3026342-14	1986	Reaction of diethyl pyrocarbonate-treated alpha 2M with hydroxylamine reversed derivatization of 43 of the 53 histidine residues.	Histidine	110-119	alpha-2-macroglobulin	Homo sapiens	42-50
3768297-2	1986	Resonances corresponding to the histidine residues in fragments of both TM and Tn-T can be resolved and assigned in the 1H NMR spectrum.	Histidine	32-41	troponin T1, slow skeletal type	Homo sapiens	79-83
3768297-5	1986	While fragment CB2 (residues 71-151) of Tn-T interacts weakly (dissociation constant of 0.1-0.2 mM) with NH2-terminal fragments of TM, this appears to be nonspecific since the absence of residues 1-10 and 128-189 of TM does not affect the observed perturbations of the titration profiles of His-79 of CB2.	Histidine	291-294	cannabinoid receptor 2	Homo sapiens	15-18
3768297-5	1986	While fragment CB2 (residues 71-151) of Tn-T interacts weakly (dissociation constant of 0.1-0.2 mM) with NH2-terminal fragments of TM, this appears to be nonspecific since the absence of residues 1-10 and 128-189 of TM does not affect the observed perturbations of the titration profiles of His-79 of CB2.	Histidine	291-294	troponin T1, slow skeletal type	Homo sapiens	40-44
3012323-4	1986	It was shown that the number of Asp, Glu and His residues on the surface of Fc is about twice as many as that of Fab.	Histidine	45-48	FA complementation group B	Homo sapiens	113-116
3003366-1	1985	We have recorded the C-2 proton resonances of the histidines of carbonmonoxyhaemoglobin A and of four abnormal human HbCOs in different buffers and at different concentrations of haemoglobin.	Histidine	50-60	complement C2	Homo sapiens	21-24
3937527-0	1985	The involvement of histidine at the active site of Harding-Passey mouse melanoma tyrosinase.	Histidine	19-28	tyrosinase	Mus musculus	81-91
3001041-3	1985	In the amino acid compositions of Ch1 and Ch2, two residues of histidine were contained in Ch2, but none in Ch1, and one residue of cysteine was contained in Ch1, but none in Ch2.	Histidine	63-72	acylphosphatase 1	Gallus gallus	42-45
3001041-3	1985	In the amino acid compositions of Ch1 and Ch2, two residues of histidine were contained in Ch2, but none in Ch1, and one residue of cysteine was contained in Ch1, but none in Ch2.	Histidine	63-72	acylphosphatase 1	Gallus gallus	91-94
3001041-3	1985	In the amino acid compositions of Ch1 and Ch2, two residues of histidine were contained in Ch2, but none in Ch1, and one residue of cysteine was contained in Ch1, but none in Ch2.	Histidine	63-72	acylphosphatase 1	Gallus gallus	91-94
3928381-3	1985	The combined results reveal a pronounced selectivity of CBPP for the peptide bonds at the carboxy ends of Ala, Val, Leu, Ser, His and Thr residues with Ala, Val and Leu most favoured, indicating a close catalytic relationship to porcine pancreatic elastase [Narayanan, A. S. &amp; Anwar, R. A.	Histidine	126-129	chymotrypsin like elastase 3B	Homo sapiens	56-60
3018530-0	1985	A mutation allowing an mRNA secondary structure diminishes translation of Saccharomyces cerevisiae iso-1-cytochrome c. The CYC1-239-O mutation in the yeast Saccharomyces cerevisiae produces a -His-Leu- replacement of the normal -Ala-Gly- sequence at amino acid positions 5 and 6, which lie within a dispensable region of iso-1-cytochrome c; this mutation can accommodate the formation of a hairpin structure at the corresponding site in the mRNA.	Histidine	193-196	cytochrome c isoform 1	Saccharomyces cerevisiae S288C	123-127
2860921-2	1985	The Cd2+ binding loci consist of the two His(B10) sites and a new site involving the Glu(B13) residues located at the center of the hexamer [Sudmeier, J. L., Bell, S. J., Storm, M. C., &amp; Dunn, M. F. (1981) Science (Washington, D.C.) 212, 560-562].	Histidine	41-44	CD2 molecule	Homo sapiens	4-7
3871336-3	1985	The pH dependence of the chemical shift of the C-2 carbon in the histidine ring of carnosine was used for estimation of the intracellular pH in the intact muscle.	Histidine	65-74	complement C2	Homo sapiens	47-50
3905514-9	1985	The hip1 deletion mutant can grow when it is supplemented with 30 mM histidine, 50 times the amount required for the growth of HIP1 cells.	Histidine	69-78	histidine permease	Saccharomyces cerevisiae S288C	4-8
3905514-9	1985	The hip1 deletion mutant can grow when it is supplemented with 30 mM histidine, 50 times the amount required for the growth of HIP1 cells.	Histidine	69-78	histidine permease	Saccharomyces cerevisiae S288C	127-131
3904081-4	1985	The sites of cleavage in the oxidized B chain of insulin were identified as Ser(9)-His(10), His(10)-Leu(11), Ala(14)-Leu(15), Leu(15)-Tyr(16) and Tyr(16)-Leu(17).	Histidine	83-86	insulin	Protobothrops mucrosquamatus	49-56
3904081-4	1985	The sites of cleavage in the oxidized B chain of insulin were identified as Ser(9)-His(10), His(10)-Leu(11), Ala(14)-Leu(15), Leu(15)-Tyr(16) and Tyr(16)-Leu(17).	Histidine	92-95	insulin	Protobothrops mucrosquamatus	49-56
6333250-10	1984	Nuclear Overhauser methods, used to differentiate direct (protonation) and indirect (conformation) effects on the chemical shift changes in the spectra of mEGF by varying the pH, yield evidence for a pH-induced conformational transition in the protein hormone associated with the breaking of the His-22 salt bridge or hydrogen bond.	Histidine	296-299	epidermal growth factor	Mus musculus	155-159
6086335-12	1984	Since this section contains the catalytic residues such as His-36 and Asp-93, we conclude that AK1 can serve as a three-dimensional model of AK2 in mechanistic and drug-designing studies.	Histidine	59-62	adenylate kinase 2	Bos taurus	141-144
6087798-1	1984	We have examined the interactions of the histidine-specific reagent diethyl pyrocarbonate (DEPC) with the components of the rat hepatic glucose-6-phosphatase system (EC 3.1.3.9).	Histidine	41-50	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	136-157
6722174-8	1984	The correlation of activity loss with histidine modification supports the view that this residue participates in the catalytic function of dopamine beta-hydroxylase.	Histidine	38-47	dopamine beta-hydroxylase	Homo sapiens	139-164
6712945-3	1984	These high-molecular-weight filaggrin precursors can be rapidly labeled with histidine and extracted from the epidermis under denaturing conditions.	Histidine	77-86	filaggrin	Homo sapiens	28-37
6325586-4	1984	At normal [Na+]i, Nao+/Hi+ exchange was undetectable at pHi greater than or equal to 6.9 but was markedly stimulated by internal acidification.	Histidine	23-26	glucose-6-phosphate isomerase	Rattus norvegicus	56-59
6325586-13	1984	At normal Nai+ values, the Nao+/Hi+ antiport of thymocytes is ideally suited for the regulation of pHi.	Histidine	32-35	glucose-6-phosphate isomerase	Rattus norvegicus	99-102
6319392-14	1984	The 6-phosphofructo-2-kinase, fructose 2,6-bisphosphatase, and ATP/ADP exchange were all inhibited by diethylpyrocarbonate, suggesting the involvement of histidine residues in all three reactions.	Histidine	154-163	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	4-57
6335884-1	1984	L-Histidine (L-His) and human serum albumin (HSA) at physiological concentrations, like the exogenous ligands D-penicillamine (D-PEN) and EDTA, are shown to inhibit the uptake of physiological levels of Ni2+ by B-lymphoblasts of human origin, human erythrocytes and rabbit alveolar macrophages.	Histidine	0-5	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	129-132
6360218-0	1983	Direct tritium-labelling into histidine of luteinizing hormone-releasing hormone agonists and use of the tracers in studies on proteolytic breakdown.	Histidine	30-39	gonadotropin releasing hormone 1	Rattus norvegicus	43-80
6360218-2	1983	In the present study, conditions for the direct 3H-labelling at the histidine residue of analogs of LHRH were worked out, circumventing the synthesis of precursor peptides for labelling.	Histidine	68-77	gonadotropin releasing hormone 1	Rattus norvegicus	100-104
6352261-5	1983	The B10 histidine, which is involved in the formation of the insulin hexamers in higher vertebrates through the co-ordination of zinc, is present in this elasmobranch insulin.	Histidine	8-17	insulin	Bos taurus	61-68
6352261-5	1983	The B10 histidine, which is involved in the formation of the insulin hexamers in higher vertebrates through the co-ordination of zinc, is present in this elasmobranch insulin.	Histidine	8-17	insulin	Bos taurus	167-174
6352261-6	1983	Several substitutions relative to bovine insulin occur in the proposed receptor binding region (A5Gln leads to His, B21Glu leads to Pro, B22Arg leads to Lys, B25Phe leads to Tyr).	Histidine	111-114	insulin	Bos taurus	41-48
8407917-4	1993	The addition of purified pyroglutamyl aminopeptidase resulted in the transformation of TRH-Gly to His-Pro-Gly and cyclo (His-Pro) but not to TRH.	Histidine	98-101	thyrotropin releasing hormone	Homo sapiens	87-90
8364203-12	1993	The active site His residue may be the target of oxidative inactivation, as evidenced by the partial protection afforded plasmin by the addition of Zn(II), histidine, or the platinum derivative, platinum(II) (2,2":6",2"-terpyridine) chloride.	Histidine	156-165	plasminogen	Homo sapiens	121-128
8103451-6	1993	Supplementing a PF diet with His was sufficient to maintain hypothalamic prepro-GRF mRNA expression, as 3 days of feeding replete rats with PF diet or PF diet with added Trp resulted in a 50% reduction in prepro-GRF mRNA, whereas levels were reduced 25% by feeding animals a PF diet with His.	Histidine	29-32	growth hormone releasing hormone	Rattus norvegicus	80-83
8395004-2	1993	The ability of spt2 mutations to suppress the transcriptional interference caused by the delta promoter insertion his-4-912 delta correlates with an increase in wild-type HIS4 mRNA levels.	Histidine	114-117	Spt2p	Saccharomyces cerevisiae S288C	15-19
8395004-9	1993	The competence of these mutant SPT2 proteins to interfere with the maintenance of the His- (Spt+) phenotype of a his4-912 delta SPT2+ strain is lost by deletion of internal HMG1-like sequences and is sensitive to the wild-type SPT2+ gene dosage.	Histidine	86-89	Spt2p	Saccharomyces cerevisiae S288C	31-35
8395004-9	1993	The competence of these mutant SPT2 proteins to interfere with the maintenance of the His- (Spt+) phenotype of a his4-912 delta SPT2+ strain is lost by deletion of internal HMG1-like sequences and is sensitive to the wild-type SPT2+ gene dosage.	Histidine	86-89	Spt2p	Saccharomyces cerevisiae S288C	128-132
12649173-1	2003	The fragile histidine triad (FHIT) gene at chromosome 3p14.2 is a tumor suppressor gene that is altered mainly by deletion in a large fraction of human tumors, including breast cancers.	Histidine	12-21	fragile histidine triad diadenosine triphosphatase	Homo sapiens	29-33
8395004-9	1993	The competence of these mutant SPT2 proteins to interfere with the maintenance of the His- (Spt+) phenotype of a his4-912 delta SPT2+ strain is lost by deletion of internal HMG1-like sequences and is sensitive to the wild-type SPT2+ gene dosage.	Histidine	86-89	hydroxymethylglutaryl-CoA reductase (NADPH) HMG1	Saccharomyces cerevisiae S288C	173-177
8395004-9	1993	The competence of these mutant SPT2 proteins to interfere with the maintenance of the His- (Spt+) phenotype of a his4-912 delta SPT2+ strain is lost by deletion of internal HMG1-like sequences and is sensitive to the wild-type SPT2+ gene dosage.	Histidine	86-89	Spt2p	Saccharomyces cerevisiae S288C	128-132
6871162-5	1983	Guaiacol, o-toluidine, and histidine brought about a frequency shift of the v4 mode for LPO but not for HRP.	Histidine	27-36	lactoperoxidase	Bos taurus	88-91
12651893-2	2003	For activating the expression of eukaryotic genes, the histidine-rich sequence in CycT1 binds the heptapeptide repeats in the C-terminal domain (CTD) of RNA polymerase II (RNAPII), whereupon Cdk9 phosphorylates the CTD.	Histidine	55-64	putative cyclin-dependent kinase 9	Caenorhabditis elegans	191-195
6843552-3	1983	The C2-H proton signal of His-435 in the CH3 domain of IgG1 was assigned by comparing the spectra of the Fc fragment of IgG1 with that of IgG3 [G3m(g)] where there is a substitution of histidine by arginine at position 435.	Histidine	26-29	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	138-142
6843552-7	1983	NMR measurements clearly show that IgG3 Jir, which was isolated from a Japanese patient with cryoglobulinemia, has histidine at position 435 as in the case of IgG1.	Histidine	115-124	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	35-39
6843552-13	1983	The pH titration curve of His-435 observed for IgG3 Jir is quite different from that for IgG1.	Histidine	26-29	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	47-51
6843552-15	1983	In the case of the pFc" fragments, His-435 gives identical titration curves for IgG1 and IgG3 [G3m(st)].	Histidine	35-38	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	89-93
6319870-2	1983	Brain angiotensin-converting enzyme (PDP-1) cleaves Hip-His-Leu, but not 80 nM [3H-Tyr1, Leu5]-enkephalin, and is markedly inhibited by several specific inhibitors such as captopril, teprotide, and <protein-id="24590">MK-422.	Histidine	56-59	pyruvate dehydrogenase phosphatase catalytic subunit 1	Rattus norvegicus	37-42
8357837-3	1993	Of 12 histidine and 3 cysteine residues, conserved between the proteins from two species, some are anticipated to form the active site of ACY-1 as either catalytic residues or ligands for an essential Zn2+ atom.	Histidine	6-15	aminoacylase 1	Homo sapiens	138-143
8394123-4	1993	The acid stabilization of insulin"s conformation was attributed to the protonation of histidine at position 5 on the B-chain (HB5) as determined by 1H-NMR of the histidines, selective amino acid alteration, and enthalpies of ionization.	Histidine	86-95	keratin 85	Homo sapiens	126-129
7852885-1	1993	Pyroglutamyglutamylprolineamide (pGlu-Glu-ProNH2) is a tripeptide with structural and immunological similarities to thyrotrophin-releasing hormone (TRH; pGlu-His-ProNH2).	Histidine	158-161	thyrotropin releasing hormone	Gallus gallus	116-146
7118436-2	1982	This rate is independent of pH throughout the pH range 5.5-8.5 as determined by pH jump from low pH with potentiometric recording of the slow approach to equilibrium pH, and by integration of the histidine C-2 and C-4 proton n.m.r.	Histidine	196-205	complement C2	Rattus norvegicus	206-209
12725421-9	2003	Our findings are consistent with a prior report that the Arg/His polymorphism in SULT1A1 is associated with breast cancer risk.	Histidine	61-64	sulfotransferase family 1A member 1	Homo sapiens	81-88
7299136-8	1981	These results suggest that the positively charged residues His-285, Lys-288, Lys-290, and Arg-292, which are located on the outer surface of the C gamma 2 domain, may be involved in the C1q-binding site of human IgG.	Histidine	59-62	complement C1q A chain	Homo sapiens	186-189
7852885-1	1993	Pyroglutamyglutamylprolineamide (pGlu-Glu-ProNH2) is a tripeptide with structural and immunological similarities to thyrotrophin-releasing hormone (TRH; pGlu-His-ProNH2).	Histidine	158-161	thyrotropin releasing hormone	Gallus gallus	148-151
12486123-1	2003	Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta.	Histidine	75-78	succinate-CoA ligase GDP-forming subunit beta	Homo sapiens	86-91
8229845-2	1993	Histidine decarboxylase in the enterochromaffin-like cells of the gastric corpus mucosa converts histidine to histamine which in turn stimulates gastric acid secretion.	Histidine	97-106	histidine decarboxylase	Rattus norvegicus	0-23
6267047-2	1981	Diphtheria toxin inactivates protein synthesis elongation factor 2 by catalyzing the ADP-ribosylation of a novel derivative of histidine, diphthamide, in the protein (Van Ness, B. G., Howard, J.	Histidine	127-136	eukaryotic translation elongation factor 2	Homo sapiens	47-66
8506386-0	1993	Breaching the conformational integrity of the catalytic triad of the serine protease plasmin: localized disruption of a side chain of His-603 strongly inhibits the amidolytic activity of human plasmin.	Histidine	134-137	plasminogen	Homo sapiens	85-92
12486123-10	2003	The sequence information produced by both methods identified specific labeled fragments of bovine Gbeta(1) that overlapped in the heptapeptide, Leu-Met-Thr-Tyr-Ser-His-Asp (amino acids 261-267).	Histidine	164-167	succinate-CoA ligase GDP-forming subunit beta	Homo sapiens	98-103
8506386-0	1993	Breaching the conformational integrity of the catalytic triad of the serine protease plasmin: localized disruption of a side chain of His-603 strongly inhibits the amidolytic activity of human plasmin.	Histidine	134-137	plasminogen	Homo sapiens	193-200
8506386-3	1993	After activation of this zymogen to its corresponding form of the serine protease plasmin (MrhPm), this latter enzyme was essentially inactive toward an amide plasmin substrate, most likely from alteration of the spatial relationships of the active-site His-603 to its partners of the catalytic triad, Asp-646 and Ser-741.	Histidine	254-257	plasminogen	Homo sapiens	82-89
7019446-1	1981	Metabolic breakdown of the luteinizing hormone-releasing hormone (LH-RH) could lead to the following fragments containing pyroglutamic acid: pyroglutamic acid (1), pGlu-His (2), pGLu-His-Trp (3), pGlu-His-Trp-Ser (4), etc., and finally pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly (10).	Histidine	169-172	gonadotropin releasing hormone 1	Rattus norvegicus	27-64
7019446-1	1981	Metabolic breakdown of the luteinizing hormone-releasing hormone (LH-RH) could lead to the following fragments containing pyroglutamic acid: pyroglutamic acid (1), pGlu-His (2), pGLu-His-Trp (3), pGlu-His-Trp-Ser (4), etc., and finally pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly (10).	Histidine	169-172	gonadotropin releasing hormone 1	Rattus norvegicus	66-71
12480932-4	2003	Analogous studies for mutated neuroglobin (mutation of E7-His to Leu, Val, or Gln) reveal the predominant presence of the nitrosyl ferrous form.	Histidine	58-61	neuroglobin	Mus musculus	30-41
7019446-1	1981	Metabolic breakdown of the luteinizing hormone-releasing hormone (LH-RH) could lead to the following fragments containing pyroglutamic acid: pyroglutamic acid (1), pGlu-His (2), pGLu-His-Trp (3), pGlu-His-Trp-Ser (4), etc., and finally pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly (10).	Histidine	183-186	gonadotropin releasing hormone 1	Rattus norvegicus	27-64
7019446-1	1981	Metabolic breakdown of the luteinizing hormone-releasing hormone (LH-RH) could lead to the following fragments containing pyroglutamic acid: pyroglutamic acid (1), pGlu-His (2), pGLu-His-Trp (3), pGlu-His-Trp-Ser (4), etc., and finally pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly (10).	Histidine	183-186	gonadotropin releasing hormone 1	Rattus norvegicus	66-71
7019446-1	1981	Metabolic breakdown of the luteinizing hormone-releasing hormone (LH-RH) could lead to the following fragments containing pyroglutamic acid: pyroglutamic acid (1), pGlu-His (2), pGLu-His-Trp (3), pGlu-His-Trp-Ser (4), etc., and finally pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly (10).	Histidine	183-186	gonadotropin releasing hormone 1	Rattus norvegicus	27-64
7019446-1	1981	Metabolic breakdown of the luteinizing hormone-releasing hormone (LH-RH) could lead to the following fragments containing pyroglutamic acid: pyroglutamic acid (1), pGlu-His (2), pGLu-His-Trp (3), pGlu-His-Trp-Ser (4), etc., and finally pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly (10).	Histidine	183-186	gonadotropin releasing hormone 1	Rattus norvegicus	66-71
8472950-1	1993	A DNA fragment encoding the yeast GAL4 transcriptional activator DNA-binding domain (amino acids 1-93) was cloned into an Escherichia coli expression vector such that the overproduced protein is tagged with six histidine residues and a factor Xa protease cleavage site.	Histidine	211-220	galactose-responsive transcription factor GAL4	Saccharomyces cerevisiae S288C	34-38
12582819-1	2003	The sperm whale myoglobin mutant H64V, where the distal histidine is mutated to valine, is known to be five coordinated in the ferric state at room temperature and physiological pH.	Histidine	56-65	myoglobin	Physeter catodon	16-25
229899-4	1979	The spectra of guanidine hydrochloride unfolded cytochrome c-552 were dependent on the pH; the titration curve showed the presence of a cooperative single transition of pK = 4.7, with a one-proton dissociation, suggesting the ionization of a histidine residue.	Histidine	242-251	cytochrome c, somatic	Equus caballus	48-60
12561436-2	2003	Fragile histidine triad (FHIT) gene is an important tumor suppressor gene at the fragile sites region of 3p14.	Histidine	8-17	fragile histidine triad diadenosine triphosphatase	Homo sapiens	25-29
37081-1	1979	The titration curves of the histidine residues of porcine lutropin and its isolated alpha and beta subunits have been determined by following the pH-dependence of the imidazole C-2 proton resonances.	Histidine	28-37	complement C2	Homo sapiens	177-180
37081-2	1979	The isolated alpha subunit contains a buried histidine, whose C-2 proton does not exchange with solvent, and which has the unusually low pK of 3.3.	Histidine	45-54	complement C2	Homo sapiens	62-65
8385489-8	1993	The pH-rate profile for the peroxidase activity indicates the involvement of the active site histidine (His64) in the rate-determining step, which these investigations suggest is attack of ArS- on ESeSAr.	Histidine	93-102	RIEG2	Homo sapiens	189-192
8384828-6	1993	These results suggest that a major role for the bridging histidine in Cu,Zn superoxide dismutase is to provide identical electrostatic steering of the substrate in the two oxidation states of the enzyme by redox-linked protonation-deprotonation processes.	Histidine	57-66	superoxide dismutase [Cu-Zn]	Bos taurus	70-96
420793-3	1979	We assign two titratable resonances (pKa = 5.1) at delta = 9.0 and 7.5 ppm at pH 2.5 and at 7.7 and 7.1 ppm at pH 9.5 to the C-2 and C-4 ring protons, respectively, of His-4.	Histidine	168-171	complement C2	Homo sapiens	125-128
420793-3	1979	We assign two titratable resonances (pKa = 5.1) at delta = 9.0 and 7.5 ppm at pH 2.5 and at 7.7 and 7.1 ppm at pH 9.5 to the C-2 and C-4 ring protons, respectively, of His-4.	Histidine	168-171	complement C4A (Rodgers blood group)	Homo sapiens	133-136
420793-4	1979	Two other titratable resonances (pKa = 5.7) at delta = 8.8 and 6.9 ppm at pH 2.5 and at 7.8 and 6.7 ppm at pH 9.5 are assigned to the C-2 and C-4 ring protons of His-32, respectively.	Histidine	162-165	complement C2	Homo sapiens	134-137
420793-4	1979	Two other titratable resonances (pKa = 5.7) at delta = 8.8 and 6.9 ppm at pH 2.5 and at 7.8 and 6.7 ppm at pH 9.5 are assigned to the C-2 and C-4 ring protons of His-32, respectively.	Histidine	162-165	complement C4A (Rodgers blood group)	Homo sapiens	142-145
12619897-4	2003	The first criteria of the screen for monoclonals was an ELISA (Enzyme Linked Immunosorbant Assay) assay performed in 96-well plates against the purified recombinant histidine-tagged aurora-A.	Histidine	165-174	aurora kinase A	Homo sapiens	182-190
99021-1	1978	Some of the histidine residues of actin and myosin are methylated after synthesis of these contractile muscle proteins.	Histidine	12-21	myosin heavy chain 14	Homo sapiens	44-50
8094490-4	1993	DNA sequencing showed a mis-sense mutation within thyroglobulin gene exon 10, resulting in a glutamine to histidine substitution.	Histidine	106-115	thyroglobulin	Homo sapiens	50-63
12576087-5	2003	All the endogenous (POMC-derived) melanocortin agonists contain the putative message sequence "His-Phe-Arg-Trp."	Histidine	95-98	pro-opiomelanocortin-alpha	Mus musculus	20-24
8498964-6	1993	Both effects were sensitive to captopril (CAS 62571-86-2) and to the renin inhibitor H-142 (H-Pro-His-Pro-Phe-His-Leu-Val-Ile-His-OH).	Histidine	98-101	renin	Rattus norvegicus	69-74
29604-6	1978	One group, with pKa in the range 6.3--6.7, is the active-site histidine residue and its deprotonation weakens binding of reduced coenzyme 3-fold.	Histidine	62-71	protein kinase cAMP-activated catalytic subunit alpha	Sus scrofa	16-19
12589073-6	2002	The Arabidopsis CRE1 histidine kinase and its related proteins AHK2 and AHK3 perceive cytokinins in the environment and transduce a signal, presumably through the AHP bridge components that carry the histidine-containing phosphotransfer (HPt) domain, to the ARR1 response regulator that transcriptionally activates genes immediately responsive to cytokinins.	Histidine	21-30	CHASE domain containing histidine kinase protein	Arabidopsis thaliana	16-20
12213229-1	2002	Cocaine administration has previously been reported to alter the levels of prepro-TRH mRNA and TRH (pGlu-His-Pro-NH(2)) in the limbic system of rats (J. Neurochem.	Histidine	105-108	thyrotropin releasing hormone	Rattus norvegicus	95-98
655262-4	1978	This acyl hydrolase activity can be simply and efficiently removed on a large scale by treatment of CoF with p-bromophenacyl bromide (BPB), an irreversible modifier of the histidine residue in the active site of phospholipase A2.	Histidine	172-181	phospholipase A2	Oryctolagus cuniculus	212-228
649256-3	1978	A description is given of the synthesis by fragment condensation of the peptide Gly-Glu-Ser-Arg-Glu-Ser-Ser-Ala-Asp-Lys-Phe-Lys-Arg-Gln-His-Met-Asp-Thr-Glu-Gly-Pro-Ser-Lys corresponding to the 1--23 amino acid sequence of rat pancreatic ribonuclease.	Histidine	136-139	ribonuclease A family member 1, pancreatic	Rattus norvegicus	226-249
8416973-7	1993	The protein has the sequence His-Asp-Glu-Leu (HDEL) at its carboxyl terminus.	Histidine	29-32	KDEL endoplasmic reticulum protein retention receptor 1	Homo sapiens	46-50
1469349-9	1992	Further deletion of gag sequences upstream of the Cys-His boxes led to the abolition of particle-forming ability, and we show that one boundary of the gag sequence necessary for particle formation lies within eight amino acids spanning one of the known protease cleavage sites at the C terminus of Pr24.	Histidine	54-57	Pr55(Gag)	Human immunodeficiency virus 1	20-23
12413488-0	2002	Identification of histidine residues important in the catalysis and structure of aspartyl aminopeptidase.	Histidine	18-27	aspartyl aminopeptidase	Homo sapiens	81-104
23288-9	1977	The chemical shifts of the C-2 and C-4 protons of histidine-12 of S-peptide are followed as a function of pH and a pK" value of 6.75 is obtained.	Histidine	50-59	complement C2	Homo sapiens	27-30
23288-9	1977	The chemical shifts of the C-2 and C-4 protons of histidine-12 of S-peptide are followed as a function of pH and a pK" value of 6.75 is obtained.	Histidine	50-59	complement C4A (Rodgers blood group)	Homo sapiens	35-38
23288-10	1977	The reassignment of the three C-2 histidine resonances of S-protein is confirmed by partial deuteration studies.	Histidine	34-43	complement C2	Homo sapiens	30-33
1327760-2	1992	It has two -Cys-Gly-His-Cys- sequences which represent two independently acting catalytic sites of PDI activity.	Histidine	20-23	prolyl 4-hydroxylase subunit beta	Homo sapiens	99-102
12413488-5	2002	Eight histidine residues of human DAP were sequentially mutated to phenylalanine.	Histidine	6-15	death associated protein	Homo sapiens	34-37
781528-4	1976	The right arm is marked with ade3 (simultaneous requirement for adenine and histidine).	Histidine	76-85	trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase ADE3	Saccharomyces cerevisiae S288C	29-33
12413488-11	2002	These studies reveal an important role for histidine residues both in catalysis and in the structural integrity of DAP.	Histidine	43-52	death associated protein	Homo sapiens	115-118
12429822-6	2002	Herein, we show that it is in fact a Golgi protein with a C-terminal TMD and shares with giantin and golgin-84 a conserved histidine in its TMD.	Histidine	123-132	golgin A5	Homo sapiens	101-110
234738-6	1975	The first three reflect residues with pK values of 7.23, 6.98, and 6 and can be assigned to the C-2 protons of histidines.	Histidine	111-121	complement C2	Homo sapiens	96-99
234738-10	1975	Six histidine C-2 protons are observed in the C enzyme and reflect groups with pK values of approximately 7.3, 6.5, 5.7, 6.6, 6.6, and 6.4.	Histidine	4-13	complement C2	Homo sapiens	14-17
234740-4	1975	Results of difference spectroscopy and observation of the C-2 resonance of an additional titratable histidine in some of these spectra suggest a conformational change in the enzyme, while the large number of unaltered resonances indicates involvement of only a few residues.	Histidine	100-109	complement C2	Homo sapiens	58-61
1527044-11	1992	One mol of histidine residue was found/mole of KS-1, KS-2, KS-4, and KM-6.	Histidine	11-20	zinc finger protein 382	Homo sapiens	47-51
1512262-8	1992	With the switch region in an open position in the R2-state, His-97 beta 2 should be able to move by Thr-41 alpha 1 and make the transition to the T-state with a steric barrier that is less than that for the R-T transition.	Histidine	60-63	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	67-73
12429822-9	2002	The conserved histidine is necessary for Coy1p"s activity in cells lacking Gos1p, suggesting that the TMD of these transmembrane Golgi coiled-coil proteins is directly involved in their function.	Histidine	14-23	cut like homeobox 1	Homo sapiens	41-46
1423781-2	1992	In order to synthesize TRH-labeled beta-D-galactosidase (beta-gal), a newly devised TRH derivative, pGlu-His-Pro-NH-(CH2)6-NH2 (TRH-Hex), was employed.	Histidine	105-108	thyrotropin releasing hormone	Homo sapiens	23-26
1423781-2	1992	In order to synthesize TRH-labeled beta-D-galactosidase (beta-gal), a newly devised TRH derivative, pGlu-His-Pro-NH-(CH2)6-NH2 (TRH-Hex), was employed.	Histidine	105-108	thyrotropin releasing hormone	Homo sapiens	84-87
1423781-2	1992	In order to synthesize TRH-labeled beta-D-galactosidase (beta-gal), a newly devised TRH derivative, pGlu-His-Pro-NH-(CH2)6-NH2 (TRH-Hex), was employed.	Histidine	105-108	thyrotropin releasing hormone	Homo sapiens	84-87
4733837-0	1973	Hydrogen-deuterium exchange kinetics of the C-2 protons of imidazole and histidine compounds.	Histidine	73-82	complement C2	Homo sapiens	44-47
12145299-3	2002	Pho2 + Swi5 activates HO, Pho2 + Pho4 activates PHO5, and Pho2 + Bas1 activates genes in the purine and histidine biosynthesis pathways.	Histidine	104-113	Bas1p	Saccharomyces cerevisiae S288C	65-69
5780195-0	1969	Hemoglobin Hasharon (alpha-2-47 his(CD5)beta-2): a hemoglobin found in low concentration.	Histidine	32-35	CD5 molecule	Homo sapiens	36-39
12093795-3	2002	The amino acids comprising the catalytic center of G6Pase include Lys(76), Arg(83), His(119), Arg(170), and His(176).	Histidine	84-87	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	51-57
5922545-16	1966	They differed, however, in that the Qbeta-protein lacked tryptophan and histidine, whereas the MS-2 protein lacked only histidine.	Histidine	120-129	MS2	Homo sapiens	95-99
1639022-2	1992	In the present study, designed to determine the role of endogenous TRH, we first characterized chromatographically the identity of immunoreactive TRH with synthetic pGlu-His-Pro-NH2.	Histidine	170-173	thyrotropin releasing hormone	Rattus norvegicus	146-149
1541289-14	1992	From the amino acid compositions, it appears that all six proteins are rich in arginine, cysteine and histidine and are closely related to pmP2 and mP2.	Histidine	102-111	peripheral myelin protein 2	Mus musculus	139-143
12093795-3	2002	The amino acids comprising the catalytic center of G6Pase include Lys(76), Arg(83), His(119), Arg(170), and His(176).	Histidine	108-111	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	51-57
12093795-4	2002	During catalysis, a His residue in G6Pase becomes phosphorylated generating an enzyme-phosphate intermediate.	Histidine	20-23	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	35-41
1605801-1	1992	Preferable conformations of thyrotropin-releasing hormone (TRH, Glp-His-Pro-NH2) and its analogues Glp-Glu(R)-Pro-NH2 (R = NHCH(CH3)CH2Ar), Glp-Gln-Abu-NH2, Dho-Gln-Abu-NH2 in DMSO solution are determined using two-dimensional 1H NMR spectroscopy (delta-J-correlated, COSY and NOESY).	Histidine	68-71	thyrotropin releasing hormone	Homo sapiens	28-57
12093795-7	2002	To identify the His residue that covalently bound the phosphate moiety, we generated recombinant adenoviruses carrying G6Pase wild type and active site mutants.	Histidine	16-19	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	119-125
1370684-6	1992	Mutation of histidine 81 in the DR1 beta chain to tyrosine reduced SEA/SEE binding, but did not prevent recognition of two DR1-restricted peptides by six of eight antigen-specific T cell lines.	Histidine	12-21	down-regulator of transcription 1	Homo sapiens	32-35
33452697-7	2021	Furthermore, using an amplified luminescent proximity homogeneous assay (Alpha) with GST-TXNIP and His-NLRP3, we obtained a small molecule named PSSM1443 that could disrupt the TXNIP-NLRP3 interaction in vitro, impairing NLRP3 downstream events.	Histidine	99-102	NLR family, pyrin domain containing 3	Mus musculus	103-108
33452697-7	2021	Furthermore, using an amplified luminescent proximity homogeneous assay (Alpha) with GST-TXNIP and His-NLRP3, we obtained a small molecule named PSSM1443 that could disrupt the TXNIP-NLRP3 interaction in vitro, impairing NLRP3 downstream events.	Histidine	99-102	NLR family, pyrin domain containing 3	Mus musculus	183-188
33452697-7	2021	Furthermore, using an amplified luminescent proximity homogeneous assay (Alpha) with GST-TXNIP and His-NLRP3, we obtained a small molecule named PSSM1443 that could disrupt the TXNIP-NLRP3 interaction in vitro, impairing NLRP3 downstream events.	Histidine	99-102	NLR family, pyrin domain containing 3	Mus musculus	183-188
12093795-11	2002	We show that after digestion of a non-glycosylated [(32)P]phosphate-G6Pase intermediate by cyanogen bromide, the [(32)P]phosphate remains bound to a peptide of 17 kDa with an isoelectric point above 9, demonstrating that His(176) is the phosphate acceptor in G6Pase.	Histidine	221-224	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	68-74
12110379-5	2002	K(i) values for the library peptides at [3H][3-Me-His(2)]TRH-labelled sites varied from 10(-3) to 10(-9)M; the potency order was: [3-Me-His(2)]&gt;His&gt;Thi&gt;Leu,Phe,Asn&gt;Gln, Arg, Thr, Ala, HomoPhe.	Histidine	136-139	thyrotropin releasing hormone	Rattus norvegicus	57-60
33942499-1	2021	In this study a histidine containing elastin-like polypeptide (ELP) diblock copolymer is described with multiresponsive assembly behavior.	Histidine	16-25	nuclear receptor subfamily 5 group A member 1	Homo sapiens	37-61
33942499-1	2021	In this study a histidine containing elastin-like polypeptide (ELP) diblock copolymer is described with multiresponsive assembly behavior.	Histidine	16-25	nuclear receptor subfamily 5 group A member 1	Homo sapiens	63-66
1428951-0	1992	Hb Ethiopia or alpha 2(140)(HC2)Tyr----His beta 2.	Histidine	39-42	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	43-49
1657933-6	1991	We suggest that at least one of the 3 histidine residues located in the rubredoxin-like center of rubrerythrin may be liganded to one iron atom of the hemerythrin-like center.	Histidine	38-47	DVU3184	Desulfovibrio vulgaris str. Hildenborough	72-82
12119112-7	2002	The predicted mature BNP comprised 35 amino acids with likely 26- and 29-aa isomers, including a histidine residue at the C-terminus.	Histidine	97-106	natriuretic peptide B	Homo sapiens	21-24
1718750-2	1991	One peptide, His-Gly-Arg-Val-Gly-Ile-Tyr-Phe-Gly-Met-Lys (peptide 11; Ile, isoleucine) is antigenic and binds with a high affinity to a monoclonal antibody that recognizes the native beta 2 subunit.	Histidine	13-16	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	183-189
33754715-9	2021	These studies suggest that the FeCN fragment in hHO-1 is tilted more strongly toward the porphyrin macrocycle compared to other histidine-ligated proteins, reflecting the propensity of the exogenous hHO-l ligands to position toward the alpha-meso-carbon, which is crucial for the HO reactivity and essential for regioselectivity.	Histidine	128-137	heme oxygenase 1	Homo sapiens	48-53
12452072-1	2002	BACKGROUND &amp; OBJECTIVE: Fragile histidine triad(FHIT), a tumor suppressor candidate gene, encompasses FRA3B, a common region with the highest fragility in the human genome, and is altered in a large number of human cancers, particularly those of epithelial cell origin and associated with known carcinogenic agents.	Histidine	36-45	fragile histidine triad diadenosine triphosphatase	Homo sapiens	52-56
33245199-1	2021	HLA-B*40:468 showed one nucleotide difference compared to HLA-B*40:06:01:01 at position 80 (A>C) Histidine to Proline residue 3.	Histidine	97-106	major histocompatibility complex, class I, B	Homo sapiens	0-5
33245199-1	2021	HLA-B*40:468 showed one nucleotide difference compared to HLA-B*40:06:01:01 at position 80 (A>C) Histidine to Proline residue 3.	Histidine	97-106	major histocompatibility complex, class I, B	Homo sapiens	58-63
1946385-12	1991	Cysteine-rich intestinal protein contains a recently identified conserved sequence of histidine and cysteine residues, the LIM motif, which our results suggest confers metal-binding properties that are important for zinc transport and/or functions of this micronutrient.	Histidine	86-95	cysteine rich protein 1	Rattus norvegicus	0-32
12452072-1	2002	BACKGROUND &amp; OBJECTIVE: Fragile histidine triad(FHIT), a tumor suppressor candidate gene, encompasses FRA3B, a common region with the highest fragility in the human genome, and is altered in a large number of human cancers, particularly those of epithelial cell origin and associated with known carcinogenic agents.	Histidine	36-45	fragile histidine triad diadenosine triphosphatase	Homo sapiens	106-111
12057912-2	2002	Our recent allelotyping analyses have indicated that chromosome 3p loss of heterozygosity (LOH), including the fragile histidine triad (FHIT) candidate tumor-suppressor gene locus at 3p14.2, is frequently detected in this neoplasm.	Histidine	119-128	fragile histidine triad diadenosine triphosphatase	Homo sapiens	136-140
1924357-6	1991	Conversely, dipeptides His-Ala, Arg-Ala, and Lys-Ala inhibit the degradation of Arg-nsP4 but not of Tyr-nsP4 or Phe-nsP4.	Histidine	23-26	serine protease 57	Homo sapiens	84-88
33258295-1	2021	HLA-B*55:71 has one nucleotide change from HLA-B*55:02:01:01 where Histidine (3) is changed to Tyrosine.	Histidine	67-76	major histocompatibility complex, class I, B	Homo sapiens	0-5
33258295-1	2021	HLA-B*55:71 has one nucleotide change from HLA-B*55:02:01:01 where Histidine (3) is changed to Tyrosine.	Histidine	67-76	major histocompatibility complex, class I, B	Homo sapiens	43-48
33750840-3	2021	Human CRISP1 is, however, one of the few family members that lack one of these characteristic histidine residues.	Histidine	94-103	cysteine rich secretory protein 1	Homo sapiens	6-12
12039800-9	2002	Dye-coupling experiments showed that HeLa-Cx43(His)(6) cells readily passed Lucifer yellow and N-(2-aminoethyl)biotinamide hydrochloride (neurobiotin); in contrast, HeLa-Cx45 and HeLa-Cx43(His)(6)/Cx45 cells showed extensive intercellular passage of neurobiotin but little coupling with Lucifer yellow.	Histidine	47-50	gap junction protein alpha 1	Homo sapiens	42-46
1868080-0	1991	Oligonucleotide site directed mutagenesis of all histidine residues within the T4 endonuclease V gene: role in enzyme-nontarget DNA binding.	Histidine	49-58	endonuclease V	Homo sapiens	82-96
1868080-1	1991	In order to evaluate the contributions that histidine residues might play both in the catalytic activities of endonuclease V and in binding to nontarget DNA, the technique of oligonucleotide site directed mutagenesis was used to create mutations at each of the four histidine residues in the endonuclease V gene.	Histidine	44-53	endonuclease V	Homo sapiens	110-124
12039800-9	2002	Dye-coupling experiments showed that HeLa-Cx43(His)(6) cells readily passed Lucifer yellow and N-(2-aminoethyl)biotinamide hydrochloride (neurobiotin); in contrast, HeLa-Cx45 and HeLa-Cx43(His)(6)/Cx45 cells showed extensive intercellular passage of neurobiotin but little coupling with Lucifer yellow.	Histidine	47-50	gap junction protein alpha 1	Homo sapiens	184-188
12039800-9	2002	Dye-coupling experiments showed that HeLa-Cx43(His)(6) cells readily passed Lucifer yellow and N-(2-aminoethyl)biotinamide hydrochloride (neurobiotin); in contrast, HeLa-Cx45 and HeLa-Cx43(His)(6)/Cx45 cells showed extensive intercellular passage of neurobiotin but little coupling with Lucifer yellow.	Histidine	189-192	gap junction protein alpha 1	Homo sapiens	42-46
33360738-0	2021	The interaction of half-sandwich (eta5-Cp*)Rh(III) cation with histidine containing peptides and their ternary species with (N,N) bidentate ligands.	Histidine	63-72	ceruloplasmin	Homo sapiens	39-42
11966977-6	2002	For these peptides, the affinity and activity at all three human receptors (MC3R, MC4R and MC5R) decreased significantly, demonstrating that the His-Phe-Arg-Trp sequence in gamma-MSH is important for activity at these three melanocortin receptors.	Histidine	145-148	melanocortin 3 receptor	Homo sapiens	76-80
33360738-1	2021	Our goal was to explore the possible interactions of the potential metallodrug (eta5-Cp*)Rh(III) complexes with histidine containing biomolecules (peptides/proteins) in order to understand the most important thermodynamic factors influencing the biospeciation and biotransformation of (eta5-Cp*)Rh(III) complexes.	Histidine	112-121	ceruloplasmin	Homo sapiens	85-88
33360738-1	2021	Our goal was to explore the possible interactions of the potential metallodrug (eta5-Cp*)Rh(III) complexes with histidine containing biomolecules (peptides/proteins) in order to understand the most important thermodynamic factors influencing the biospeciation and biotransformation of (eta5-Cp*)Rh(III) complexes.	Histidine	112-121	ceruloplasmin	Homo sapiens	291-294
1859409-2	1991	By considering the structure of the protease"s cDNA, we concluded that His-238 is the C-terminal residue of medullasin.	Histidine	71-74	elastase, neutrophil expressed	Homo sapiens	108-118
1859409-3	1991	Therefore, medullasin is composed of 238 amino acid residues with Ile as the amino terminal and His as the carboxyl terminal.	Histidine	96-99	elastase, neutrophil expressed	Homo sapiens	11-21
33360738-2	2021	To this end, here we report systematic solution thermodynamic and solution structural study on the interaction of (eta5-Cp*)Rh(III) cation with histidine containing peptides and their constituents ((N-methyl)imidazole, GGA-OH, GGH-OH, histidine-amide, HGG-OH, GHG-NH2), based on extensive 1H NMR, ESI-MS and potentiometric investigations.	Histidine	144-153	ceruloplasmin	Homo sapiens	120-123
11931695-5	2002	The inhibitory action of histidine was enhanced significantly by thioperamide (5 microg), however, was antagonized by both alpha fluoromethylhistidine (20 microg), a selective histidine decarboxylase inhibitor and H1 ant agonist pyrilamine (2, 5 mg/kg), dose-dependently and significantly.	Histidine	25-34	histidine decarboxylase	Rattus norvegicus	176-199
33360738-2	2021	To this end, here we report systematic solution thermodynamic and solution structural study on the interaction of (eta5-Cp*)Rh(III) cation with histidine containing peptides and their constituents ((N-methyl)imidazole, GGA-OH, GGH-OH, histidine-amide, HGG-OH, GHG-NH2), based on extensive 1H NMR, ESI-MS and potentiometric investigations.	Histidine	144-153	gamma-glutamyl hydrolase	Homo sapiens	227-230
33360738-5	2021	At pH 7.4 the (eta5-Cp*)Rh(III) binding affinity of peptides follow the order GGA-OH < < GGH-OH < < histidine-amide < HGG-OH < GHG-NH2, i.e. the observed binding strength essentially depends on the presence and position of histidine within the peptide sequence.	Histidine	100-109	ceruloplasmin	Homo sapiens	20-23
33360738-5	2021	At pH 7.4 the (eta5-Cp*)Rh(III) binding affinity of peptides follow the order GGA-OH < < GGH-OH < < histidine-amide < HGG-OH < GHG-NH2, i.e. the observed binding strength essentially depends on the presence and position of histidine within the peptide sequence.	Histidine	223-232	ceruloplasmin	Homo sapiens	20-23
33189720-4	2021	Exchange activity of arginine and histidine/arginine, as observed for Ypq2 of S. cerevisiae, was also detected in the vesicles expressing stm1+.	Histidine	34-43	Stm1p	Saccharomyces cerevisiae S288C	138-142
33189720-5	2021	The expression levels of stm1+ in S. pombe cells significantly affected the vacuolar contents of lysine, histidine, and arginine.	Histidine	105-114	Stm1p	Saccharomyces cerevisiae S288C	25-29
1680656-6	1991	The pseudo-first order rate constants for inactivation of low-KM ALDH depends on both effects, suggesting that electrostatic forces are involved in the process and that a group with pK approximately 6.8, presumably a histidine residue, at the active site of ALDH could be involved.	Histidine	217-226	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	65-69
1680656-6	1991	The pseudo-first order rate constants for inactivation of low-KM ALDH depends on both effects, suggesting that electrostatic forces are involved in the process and that a group with pK approximately 6.8, presumably a histidine residue, at the active site of ALDH could be involved.	Histidine	217-226	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	258-262
1646804-1	1991	The primary amino acid sequence of the major herpes simplex virus type 1 (HSV-1)-infected cell polypeptide 8 (ICP8) deduced from the DNA sequence of the unique long open reading frame 29 (UL29 ORF) contains a potential metal-binding domain of the form Cys-X2-5-Cys-X2-15-A-X2-4-A where A may be either histidine or cysteine and X is any amino acid.	Histidine	302-311	single-stranded DNA-binding protein	Human alphaherpesvirus 1	188-192
32525264-5	2021	Compared to galectin-1, -3 and -8, Gal-14 has two key amino acids (a histidine and an arginine) in the normally conserved, canonical sugar binding site are substituted by glutamine (Gln53) and histidine (His57), thus likely explaining why lactose binding to this lectin is very weak.	Histidine	69-78	galectin 14	Homo sapiens	35-41
11920739-1	2002	Clear cell renal cell carcinomas (RCCs) are characterized by a deletion of chromosome 3p, which might result in the inactivation of the FHIT (fragile histidine triad) gene, a putative tumour suppressor gene.	Histidine	150-159	fragile histidine triad diadenosine triphosphatase	Homo sapiens	136-140
32525264-5	2021	Compared to galectin-1, -3 and -8, Gal-14 has two key amino acids (a histidine and an arginine) in the normally conserved, canonical sugar binding site are substituted by glutamine (Gln53) and histidine (His57), thus likely explaining why lactose binding to this lectin is very weak.	Histidine	193-202	galectin 14	Homo sapiens	35-41
33280408-5	2021	The effects of S1P inhibition were all reversed by supplement with histidine-tagged sPRR termed as sPRR-His.	Histidine	67-76	membrane-bound transcription factor peptidase, site 1	Mus musculus	15-18
11884585-2	2002	The HAT domains of CBP and p300 are characterized by the presence of a highly conserved putative plant homeodomain (PHD) (C4HC3) type zinc finger, which is part of the functionally uncharacterized cysteine-histidine-rich region 2 (CH2).	Histidine	206-215	E1A binding protein p300	Homo sapiens	27-31
1711024-11	1991	This protein is highly homologous with the AroP (general aromatic transport) system of E. coli (59.6% identity) and to a lesser extent with the yeast permeases CAN1 (arginine), PUT4 (proline), and HIP1 (histidine) of Saccharomyces cerevisiae.	Histidine	203-212	proline permease PUT4	Saccharomyces cerevisiae S288C	177-181
12074388-6	2002	For the class of imidazole derivatives such rules are derived, and a model degradation mechanism is proposed in analogy to the urocanate-hydratase mechanism from histidine metabolism.	Histidine	162-171	urocanate hydratase 1	Homo sapiens	127-146
2026610-8	1991	The purified enzyme phosphorylates specifically histidine 75 in histone H4 and does not phosphorylate histidine 18 nor histidine residues in any other core histone.	Histidine	48-57	histone H4	Saccharomyces cerevisiae S288C	64-74
33335079-7	2021	In deletion mutant analyses, large portions of the TDAG51 domains, including the pleckstrin homology-like, glutamine repeat and prolineglutamine repeat domains but not the proline-histidine repeat domain, are involved in the interaction with the region between residues 140 and 506, including the DNA binding domain, hinge, ligand binding domain and activation function-2 domain, in PPARgamma.	Histidine	180-189	pleckstrin homology like domain, family A, member 1	Mus musculus	51-57
21315018-1	2002	BACKGROUND: To investigate the role of FHIT (fragile histidine triad) gene in oncogenesis and progression of human lung cancer.	Histidine	53-62	fragile histidine triad diadenosine triphosphatase	Homo sapiens	39-43
32705968-6	2020	Histidine 193 plays an important role in the inhibition of UGCG via a known UGCG inhibitor, D-PDMP.	Histidine	0-9	UDP-glucose ceramide glucosyltransferase	Homo sapiens	59-63
32705968-6	2020	Histidine 193 plays an important role in the inhibition of UGCG via a known UGCG inhibitor, D-PDMP.	Histidine	0-9	UDP-glucose ceramide glucosyltransferase	Homo sapiens	76-80
32705968-7	2020	However, cambinol was found to inhibit UGCG activity in a histidine 193-independent manner.	Histidine	58-67	UDP-glucose ceramide glucosyltransferase	Homo sapiens	39-43
11896765-4	2002	Microinjection of a His-tagged HdCdtB subunit, homologous to the mammalian DNase I, was sufficient to induce re-localization of the Mre11 complex 1 h post treatment.	Histidine	20-23	deoxyribonuclease 1	Bos taurus	75-82
11795944-5	2002	Association of endogenous Gas7 protein with microfilaments was verified by F-actin affinity chromatography; direct binding of purified His-Gas7 to actin also was demonstrated and shown to be mediated by the Gas7 C-terminal domain.	Histidine	135-138	growth arrest specific 7	Mus musculus	139-143
33057331-1	2020	Diphthamide is a unique post-translationally modified histidine residue (His715 in all mammals) found only in eukaryotic elongation factor-2 (eEF-2).	Histidine	54-63	eukaryotic translation elongation factor 2	Homo sapiens	110-140
33057331-1	2020	Diphthamide is a unique post-translationally modified histidine residue (His715 in all mammals) found only in eukaryotic elongation factor-2 (eEF-2).	Histidine	54-63	eukaryotic translation elongation factor 2	Homo sapiens	142-147
2037047-4	1991	Alternative mechanisms of ligand stabilization may therefore be operative in Mb"s lacking the distal histidine.	Histidine	101-110	myoglobin	Physeter catodon	77-79
2069873-9	1991	Replacement of some of these cysteine and histidine residues completely abolished the transforming activity of vav genes.	Histidine	42-51	vav guanine nucleotide exchange factor 1	Homo sapiens	111-114
11795944-5	2002	Association of endogenous Gas7 protein with microfilaments was verified by F-actin affinity chromatography; direct binding of purified His-Gas7 to actin also was demonstrated and shown to be mediated by the Gas7 C-terminal domain.	Histidine	135-138	growth arrest specific 7	Mus musculus	139-143
11738621-1	2002	We report synthesis and biological activities of several thyrotropin-releasing hormone (TRH) analogues in which the N-terminal pyroglutamic acid residue has been replaced with various carboxylic acids and the central histidine is modified with substituted-imidazole derivatives.	Histidine	217-226	thyrotropin releasing hormone	Homo sapiens	57-86
1991896-1	1991	Patients with atrioventricular (AV) node reentrant tachycardia characteristically have short and constant retrograde His-atrium conduction times (H2A2 intervals) during the introduction of ventricular extrastimuli.	Histidine	117-120	H2A clustered histone 18	Homo sapiens	146-150
33101590-10	2020	Rh-CSF1 treatment significantly attenuated neurological deficits, infarct volume, OS, neuronal apoptosis, and degeneration at 48 h after HI.	Histidine	137-139	colony stimulating factor 1	Homo sapiens	3-7
33101590-13	2020	These results suggested that rh-CSF1 treatment attenuated OS-induced neuronal degeneration and apoptosis after HI, at least in part, through the CSF1R/PLCG2/PKA/UCP2 signaling pathway.	Histidine	111-113	colony stimulating factor 1	Homo sapiens	32-36
32860079-11	2020	In summary, our studies indicate that NME1 and NME2 are involved in TGF-beta1-induced HSC activation and CCl4-induced liver fibrosis, which may be mediated by histidine phosphorylation.	Histidine	159-168	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	47-51
32860079-11	2020	In summary, our studies indicate that NME1 and NME2 are involved in TGF-beta1-induced HSC activation and CCl4-induced liver fibrosis, which may be mediated by histidine phosphorylation.	Histidine	159-168	fucosyltransferase 1 (H blood group)	Homo sapiens	86-89
32860079-11	2020	In summary, our studies indicate that NME1 and NME2 are involved in TGF-beta1-induced HSC activation and CCl4-induced liver fibrosis, which may be mediated by histidine phosphorylation.	Histidine	159-168	C-C motif chemokine ligand 4	Homo sapiens	105-109
32579975-5	2020	Only when PD-1 interacts with PD-L1 did the FSY react with a proximal histidine of PD-L1 selectively, enabling irreversible binding of PD-1 to only PD-L1 in vitro and in vivo.	Histidine	70-79	CD274 molecule	Homo sapiens	83-88
1846969-4	1991	Fusion of the Ty1-H3mHIS3AI element to the inducible GAL1 promoter resulted in a high frequency of histidine prototrophs upon galactose induction.	Histidine	99-108	galactokinase	Saccharomyces cerevisiae S288C	53-57
11738621-1	2002	We report synthesis and biological activities of several thyrotropin-releasing hormone (TRH) analogues in which the N-terminal pyroglutamic acid residue has been replaced with various carboxylic acids and the central histidine is modified with substituted-imidazole derivatives.	Histidine	217-226	thyrotropin releasing hormone	Homo sapiens	88-91
11788786-5	2002	Pretreatment of the rats with an ip bolus injection of alpha-fluoromethylhistidine, a suicide inhibitor of a histidine decarboxylase (HDC), at a dosage of 224 micromol/kg blocked the conversion of histidine into histamine and attenuated the suppressive effect of histidine on food intake from 64.2% to 88.1% of the controls (P &lt; 0.05).	Histidine	73-82	histidine decarboxylase	Rattus norvegicus	109-132
1671047-5	1991	The inhibition of protein synthesis caused by histidine deprivation alone was accompanied by a 2-fold increase in the number of free ribosomal particles, a 29% decrease in Met-tRNA(i) binding to 43 S preinitiation complexes, and a 31% reduction in activity of eukaryotic initiation factor 2B (eIF-2B).	Histidine	46-55	eukaryotic translation initiation factor 2B subunit delta	Rattus norvegicus	260-291
32371395-10	2020	Substitution of either conserved histidine compromised the ability of Sts-1 to suppress signaling pathways downstream of both the TCR and the Dectin-1 receptor.	Histidine	33-42	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	130-133
32392889-5	2020	NME1 and NME2 have been shown to possess histidine (His) kinase activity.	Histidine	41-50	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	9-13
1671047-5	1991	The inhibition of protein synthesis caused by histidine deprivation alone was accompanied by a 2-fold increase in the number of free ribosomal particles, a 29% decrease in Met-tRNA(i) binding to 43 S preinitiation complexes, and a 31% reduction in activity of eukaryotic initiation factor 2B (eIF-2B).	Histidine	46-55	eukaryotic translation initiation factor 2B subunit delta	Rattus norvegicus	293-299
11788786-5	2002	Pretreatment of the rats with an ip bolus injection of alpha-fluoromethylhistidine, a suicide inhibitor of a histidine decarboxylase (HDC), at a dosage of 224 micromol/kg blocked the conversion of histidine into histamine and attenuated the suppressive effect of histidine on food intake from 64.2% to 88.1% of the controls (P &lt; 0.05).	Histidine	73-82	histidine decarboxylase	Rattus norvegicus	134-137
1671047-6	1991	By comparison, histidine deprivation combined with histidinol addition resulted in a 3-fold increase in free ribosomal particles, a 66% decrease in Met-tRNAi binding, and a 78% reduction in eIF-2B activity.	Histidine	15-24	eukaryotic translation initiation factor 2B subunit delta	Rattus norvegicus	190-196
11788786-5	2002	Pretreatment of the rats with an ip bolus injection of alpha-fluoromethylhistidine, a suicide inhibitor of a histidine decarboxylase (HDC), at a dosage of 224 micromol/kg blocked the conversion of histidine into histamine and attenuated the suppressive effect of histidine on food intake from 64.2% to 88.1% of the controls (P &lt; 0.05).	Histidine	109-118	histidine decarboxylase	Rattus norvegicus	134-137
11788786-7	2002	HDC activity was increased simultaneously by histidine administration compared with the controls (P &lt; 0.05).	Histidine	45-54	histidine decarboxylase	Rattus norvegicus	0-3
32202304-1	2020	Ubiquitin-specific protease 26 (USP26) encodes a predicted protein containing his- and cys- domains that are conserved among deubiquitinating enzymes.	Histidine	78-81	ubiquitin specific peptidase 26	Homo sapiens	0-30
11747299-2	2001	A construct encoding PP1beta9C with a short NH(2)-terminal fusion including six histidine residues was introduced into the X-33 and KM71H strains of P. pastoris by homologous recombination.	Histidine	80-89	flapwing	Drosophila melanogaster	21-30
32202304-1	2020	Ubiquitin-specific protease 26 (USP26) encodes a predicted protein containing his- and cys- domains that are conserved among deubiquitinating enzymes.	Histidine	78-81	ubiquitin specific peptidase 26	Homo sapiens	32-37
32346830-4	2020	Cu2+ can decrease fluorescence of NAC-AuNCs, and then L-His can effectively recover the fluorescence of NAC-AuNCs.	Histidine	54-59	synuclein alpha	Homo sapiens	104-107
32346830-5	2020	The possible reason is that the stronger affinity between Cu2+ and L-His can pull Cu2+ away from the surface of NAC-AuNCs.	Histidine	67-72	synuclein alpha	Homo sapiens	112-115
1989490-9	1991	Histidinol dehydrogenase is the first histidine enzyme that has been purified to homogeneity and characterized from plants.	Histidine	38-47	histidinol dehydrogenase, chloroplastic	Brassica oleracea	0-24
1864444-6	1991	Reversion of the diethylpyrocarbonate reaction with hydroxylamine as well as protection of the enzymes with uroporphyrinogen III indicated that histidine is involved at least in the first decarboxylation active site of the porphyrinogen carboxylyase, and perhaps in one or more sites where the removal of the other carboxyl groups take place.	Histidine	144-153	uroporphyrinogen decarboxylase	Rattus norvegicus	223-249
11724898-6	2001	Moreover, incubation of the tissue sections with an anti-IGFR-1 blocking antibody abolished IGF-1-His binding, demonstrating that the interaction was mediated by the IGFR-1.	Histidine	98-101	Fc gamma receptor Ic, pseudogene	Homo sapiens	57-63
11724898-6	2001	Moreover, incubation of the tissue sections with an anti-IGFR-1 blocking antibody abolished IGF-1-His binding, demonstrating that the interaction was mediated by the IGFR-1.	Histidine	98-101	Fc gamma receptor Ic, pseudogene	Homo sapiens	166-172
11724898-8	2001	The IGF-1-His binding pattern was observed in brain, cartilage, lung, skin, heart, diaphragm, and tongue, and paralleled the previously reported IGFR-1 distribution.	Histidine	10-13	Fc gamma receptor Ic, pseudogene	Homo sapiens	145-151
2121465-1	1990	TRH (pGlu-His-Pro-NH2) arises from the post-translational processing of a larger precursor peptide containing multiple copies of the TRH progenitor sequence, Gln-His-Pro-Gly.	Histidine	10-13	thyrotropin releasing hormone	Rattus norvegicus	0-3
11689613-4	2001	When tested in an RSV minigenome replicon system using beta-galactosidase as a reporter gene, C7G, C15G, and C21G located in the Cys(3)-His(1) motif showed a significant reduction in processive RNA synthesis compared to wild-type (wt) M2-1.	Histidine	136-139	galactosidase beta 1	Homo sapiens	55-73
2121465-1	1990	TRH (pGlu-His-Pro-NH2) arises from the post-translational processing of a larger precursor peptide containing multiple copies of the TRH progenitor sequence, Gln-His-Pro-Gly.	Histidine	10-13	thyrotropin releasing hormone	Rattus norvegicus	133-136
2121465-1	1990	TRH (pGlu-His-Pro-NH2) arises from the post-translational processing of a larger precursor peptide containing multiple copies of the TRH progenitor sequence, Gln-His-Pro-Gly.	Histidine	162-165	thyrotropin releasing hormone	Rattus norvegicus	0-3
2121465-1	1990	TRH (pGlu-His-Pro-NH2) arises from the post-translational processing of a larger precursor peptide containing multiple copies of the TRH progenitor sequence, Gln-His-Pro-Gly.	Histidine	162-165	thyrotropin releasing hormone	Rattus norvegicus	133-136
32321505-12	2020	Total protein was positively correlated with PHE and TRP (both p = 0.031, r = 0.30) and albumin was positively correlated with HIS (p = 0.025, r = 0.31), PHE and TRP (both p = 0.001, r = 0.46).	Histidine	127-130	albumin	Canis lupus familiaris	88-95
32741898-9	2020	These results revealed that the changes in the histidine catabolism by PPARalpha agonists might be partially, but not directly, involved in the hepatocyte proliferation in rats, and there is a large genetic distance even between rat and mouse.	Histidine	47-56	peroxisome proliferator activated receptor alpha	Rattus norvegicus	71-80
2117926-5	1990	The enzyme was inhibited by alpha-fluoromethylhistidine but not by carbidopa, was unable to form dopamine from L-3,4-dihydroxyphenylalanine, and had a Km value for histidine of 0.27 mM, indicating that it was HDC and not aromatic amino acid decarboxylase.	Histidine	46-55	histidine decarboxylase	Homo sapiens	209-212
11553629-6	2001	When the critical histidine residue 473 in CPT I (327 in COT), localized in the acyl-CoA pocket in the model, was mutated to alanine, the catalytic activity was abolished.	Histidine	18-27	carnitine palmitoyltransferase 1B	Rattus norvegicus	43-48
31493373-5	2019	In this work, we characterized a highly conserved histidine (H208), present at TM5-ICL3 region of T2R14 and its role in agonist-induced T2R14 signaling.	Histidine	50-59	taste 2 receptor member 14	Homo sapiens	98-103
31493373-5	2019	In this work, we characterized a highly conserved histidine (H208), present at TM5-ICL3 region of T2R14 and its role in agonist-induced T2R14 signaling.	Histidine	50-59	taste 2 receptor member 14	Homo sapiens	136-141
11553629-6	2001	When the critical histidine residue 473 in CPT I (327 in COT), localized in the acyl-CoA pocket in the model, was mutated to alanine, the catalytic activity was abolished.	Histidine	18-27	carnitine O-octanoyltransferase	Rattus norvegicus	57-60
11553629-7	2001	Mutation of the conserved alanine residue to aspartic acid, A381D (in CPT I) and A238D (in COT), which are 92/89 amino acids far from the catalytic histidine, respectively (but very close to the acyl-CoA pocket in the structural model), decreased the activity by 86 and 80%, respectively.	Histidine	148-157	carnitine O-octanoyltransferase	Rattus norvegicus	91-94
11524427-1	2001	The human metalloregulatory transcription factor, metal-response element (MRE)-binding transcription factor-1 (MTF-1), contains six TFIIIA-type Cys(2)-His(2) motifs, each of which was projected to form well-structured betabetaalpha domains upon Zn(II) binding.	Histidine	151-154	metal regulatory transcription factor 1	Homo sapiens	50-109
31167910-11	2019	Collectively, our data indicate that the essential HBx cysteine and histidine residues form a zinc-binding motif that is required for HBx function.IMPORTANCE The structural maintenance of chromosomes 5/6 complex (Smc5/6) is a host restriction factor that suppresses HBV transcription.	Histidine	68-77	X protein	Hepatitis B virus	134-137
2395880-0	1990	Substitution of a single amino acid (aspartic acid for histidine) converts the functional activity of human complement C4B to C4A.	Histidine	55-64	complement C4B (Chido blood group)	Homo sapiens	108-122
2118634-1	1990	The kinetics and mechanism of degradation of the tripeptide TRH (pGlu-His-Pro-NH2) and its various primary and secondary degradation products (TRH-OH, His-Pro-NH2, and His-Pro) have been determined in human plasma at 37 degrees C. The rates of degradation of both TRH and TRH-OH (pGlu-His-Pro) showed mixed zero-order and first-order kinetics.	Histidine	70-73	thyrotropin releasing hormone	Homo sapiens	60-63
11524427-1	2001	The human metalloregulatory transcription factor, metal-response element (MRE)-binding transcription factor-1 (MTF-1), contains six TFIIIA-type Cys(2)-His(2) motifs, each of which was projected to form well-structured betabetaalpha domains upon Zn(II) binding.	Histidine	151-154	metal regulatory transcription factor 1	Homo sapiens	111-116
11604542-5	2001	Low pK(a) values of 5.3, 5.3, 3.9, 1.7, and 4.7 have been calculated for five functionally important histidines, His108, His119, His121, His132, and His137, respectively, using the high pH E70A GART structure.	Histidine	101-111	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	Homo sapiens	194-198
2300558-2	1990	In biological systems the formation of histamine from its precursor histidine is catalyzed by the enzyme L-histidine decarboxylase (HDC; L-histidine carboxy-lyase, EC 4.1.1.22).	Histidine	68-77	histidine decarboxylase	Rattus norvegicus	105-130
2300558-2	1990	In biological systems the formation of histamine from its precursor histidine is catalyzed by the enzyme L-histidine decarboxylase (HDC; L-histidine carboxy-lyase, EC 4.1.1.22).	Histidine	68-77	histidine decarboxylase	Rattus norvegicus	132-135
31073693-7	2019	In the cell line LN405, the competitive inhibitors beta-alanyl-L-alanine (inhibits all transporters) and L-histidine (inhibitor of PHT1/2) both inhibited the uptake of carnosine.	Histidine	105-116	solute carrier family 15 member 4	Homo sapiens	131-137
31220181-3	2019	Crystal structure of A26 protein revealed that His48 and His53 are in close contact with Lys47, Arg57, His314 and Arg312, suggesting that at low pH these His-cation pairs could initiate conformational changes through protonation of His48 and His53 and subsequent electrostatic repulsion.	Histidine	47-50	immunoglobulin kappa variable 6-21 (non-functional)	Homo sapiens	21-24
11604543-10	2001	Using the formylated locally minimized construct of GART, a high pK(a) for His108 was calculated, indicating a protonated histidine, and a low pK(a) for GAR(NH(2)) was calculated, indicating that GAR is in neutral form.	Histidine	122-131	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	Homo sapiens	52-56
30807919-10	2019	These results suggested that S1PC alters histidine metabolism and consequently exerts the antihypertensive effect via the central histamine H3 receptor.	Histidine	41-50	histamine receptor H3	Rattus norvegicus	130-151
34699768-3	2022	Control of hAQP10-mediated glycerol flux has been linked to the cytoplasmic end of the channel, where a unique loop is regulated by the protonation status of histidine 80 (H80).	Histidine	158-167	aquaporin 10	Homo sapiens	11-17
11753800-2	2001	Recently, the genetic defect has been mapped to chromosome 7q35 and consists mainly of a point mutation in exon 3 of the cationic trypsinogen gene which causes an Arg(CGC)-His(CAC) substitution at residue 117.	Histidine	172-175	serine protease 1	Homo sapiens	121-141
11473116-8	2001	These results support a mechanism for copper transfer in which CCS and SOD1 dock via their highly conserved dimer interfaces in a manner that precisely orients the Cys-rich copper donor sites of CCS and the His-rich acceptor sites of SOD1 to form a copper-bridged intermediate.	Histidine	207-210	copper chaperone for superoxide dismutase	Homo sapiens	63-66
34954523-11	2022	The intracellular histidine increased under ox-LDL condition, which was further increased by Hdc knockout.	Histidine	18-27	histidine decarboxylase	Mus musculus	93-96
31087539-4	2019	To test this hypothesis, we compared changes in the kidney structure and function in control mice and mice that carry a point mutation at a conserved histidine (H355Y) of SIRT1 that renders the enzyme catalytically inactive.	Histidine	150-159	sirtuin 1	Mus musculus	171-176
11473116-8	2001	These results support a mechanism for copper transfer in which CCS and SOD1 dock via their highly conserved dimer interfaces in a manner that precisely orients the Cys-rich copper donor sites of CCS and the His-rich acceptor sites of SOD1 to form a copper-bridged intermediate.	Histidine	207-210	copper chaperone for superoxide dismutase	Homo sapiens	195-198
11473128-2	2001	Spectral measurements with human and mouse recombinant neuroglobin provide evidence for a hexacoordinated deoxy ferrous (Fe(2+)) form, indicating a His-Fe(2+)-His binding scheme.	Histidine	148-151	neuroglobin	Mus musculus	55-66
31133770-3	2019	These studies showed that mutation of the proximal histidine residue with both natural and non-natural amino acids result in stable myoglobin variants that can function as both carbene and nitrene transferases.	Histidine	51-60	myoglobin	Homo sapiens	132-141
31133770-4	2019	In addition, substitution of the proximal histidine with an aspartate residue led to a myoglobin-based catalyst capable of promoting stereoselective olefin cyclopropanation under nonreducing conditions.	Histidine	42-51	myoglobin	Homo sapiens	87-96
34572578-4	2021	The genuine 4-HNE-Enzyme-Linked Immunosorbent Assay (HNE-ELISA), based on monoclonal antibody specific for HNE-histidine (HNE-His) adducts, was used to determine plasma HNE-protein conjugates.	Histidine	111-120	elastase, neutrophil expressed	Homo sapiens	107-110
34572578-4	2021	The genuine 4-HNE-Enzyme-Linked Immunosorbent Assay (HNE-ELISA), based on monoclonal antibody specific for HNE-histidine (HNE-His) adducts, was used to determine plasma HNE-protein conjugates.	Histidine	126-129	elastase, neutrophil expressed	Homo sapiens	122-125
11473128-2	2001	Spectral measurements with human and mouse recombinant neuroglobin provide evidence for a hexacoordinated deoxy ferrous (Fe(2+)) form, indicating a His-Fe(2+)-His binding scheme.	Histidine	159-162	neuroglobin	Mus musculus	55-66
11473128-4	2001	The ferric (Fe(3+)) form of neuroglobin is also hexacoordinated with the protein ligand E7-His and does not exhibit pH dependence.	Histidine	91-94	neuroglobin	Mus musculus	28-39
11768238-1	2001	The FHIT (fragile histidine triad) gene located at chromosome 3p14.2 has been proposed as a candidate tumor suppressor gene in human cancers.	Histidine	18-27	fragile histidine triad diadenosine triphosphatase	Homo sapiens	4-8
34092254-3	2021	The tumor suppressor gene, Fragile Histidine Triad Diadenosine Triphosphatase (FHIT), is frequently lost in cancer through epigenetic modifications and/or deletion.	Histidine	35-44	fragile histidine triad diadenosine triphosphatase	Homo sapiens	79-83
30842276-3	2019	We demonstrate that mda-7/IL-24, administered through a replication incompetent type 5 adenovirus (Ad.mda-7) or with His-MDA-7/IL-24 protein, down-regulates DICER, a critical regulator in miRNA processing.	Histidine	117-120	interleukin 24	Homo sapiens	20-25
30842276-3	2019	We demonstrate that mda-7/IL-24, administered through a replication incompetent type 5 adenovirus (Ad.mda-7) or with His-MDA-7/IL-24 protein, down-regulates DICER, a critical regulator in miRNA processing.	Histidine	117-120	interleukin 24	Homo sapiens	26-31
30842276-3	2019	We demonstrate that mda-7/IL-24, administered through a replication incompetent type 5 adenovirus (Ad.mda-7) or with His-MDA-7/IL-24 protein, down-regulates DICER, a critical regulator in miRNA processing.	Histidine	117-120	interleukin 24	Homo sapiens	121-126
30842276-3	2019	We demonstrate that mda-7/IL-24, administered through a replication incompetent type 5 adenovirus (Ad.mda-7) or with His-MDA-7/IL-24 protein, down-regulates DICER, a critical regulator in miRNA processing.	Histidine	117-120	interleukin 24	Homo sapiens	127-132
30842276-3	2019	We demonstrate that mda-7/IL-24, administered through a replication incompetent type 5 adenovirus (Ad.mda-7) or with His-MDA-7/IL-24 protein, down-regulates DICER, a critical regulator in miRNA processing.	Histidine	117-120	dicer 1, ribonuclease III	Homo sapiens	157-162
11451959-0	2001	Glutamate 170 of human l-3-hydroxyacyl-CoA dehydrogenase is required for proper orientation of the catalytic histidine and structural integrity of the enzyme.	Histidine	109-118	enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase	Homo sapiens	23-56
11451959-2	2001	Similar to other dehydrogenases, HAD contains a general acid/base, His(158), which is within hydrogen bond distance of a carboxylate, Glu(170).	Histidine	67-70	enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase	Homo sapiens	33-36
30740100-7	2019	In Sardinia, the prevalence of HLA-B*2709, which differs from the strongly AS-associated B*2705 prototype for one amino acid (His/Asp116) in the F pocket of the peptide binding groove, is around 20% of all HLA-B27 alleles.	Histidine	126-129	major histocompatibility complex, class I, B	Homo sapiens	31-36
35504076-6	2022	The umami structures in the six core umami peptides with the lowest binding energy were easy to connect with Ser, Glu, His, Gln, Arg and Lys residues in T1R3 through hydrogen bond and salt bridge.	Histidine	119-122	taste 1 receptor member 3	Homo sapiens	153-157
11566179-1	2001	We investigated the localization of histidine decarboxylase (HDC), which is the rate-limiting enzyme that generates histamine from histidine, in human aorta/coronary artery.	Histidine	36-45	histidine decarboxylase	Homo sapiens	61-64
35525598-2	2022	By immobilizing histidine (His)-tagged SARS-CoV-2 spike (S1) protein onto tris-nitrilotriacetic acid (tris-NTA) sensor and using the early association phase for mass-transfer-controlled concentration determination, we developed a rapid and regenerable surface plasmon resonance (SPR) method for quantifying anti-SARS-CoV-2 antibody.	Histidine	16-25	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	50-55
35525598-2	2022	By immobilizing histidine (His)-tagged SARS-CoV-2 spike (S1) protein onto tris-nitrilotriacetic acid (tris-NTA) sensor and using the early association phase for mass-transfer-controlled concentration determination, we developed a rapid and regenerable surface plasmon resonance (SPR) method for quantifying anti-SARS-CoV-2 antibody.	Histidine	27-30	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	50-55
30554660-5	2019	GST-SSL5 was found to attenuate the inhibitory activity of recombinant histidine-tagged C1Inh (C1Inh-His) toward complement C1s.	Histidine	71-80	glutathione S-transferase kappa 1	Homo sapiens	0-3
11387315-8	2001	To answer this question, we utilized the two previously described mutant forms of PTHR, H401 and H402, which contain a naturally present histidine residue at position 301 in H3 and a second substituted histidine residue at positions 401 and 402 in H6, respectively.	Histidine	137-146	parathyroid hormone like hormone	Homo sapiens	82-86
31140178-7	2019	Herein, we demonstrated that nitro-oleic acid (NO2-OA) nitroalkylate alpha-syn, forming a covalent adduct at histidine-50.	Histidine	109-118	synuclein alpha	Homo sapiens	69-78
30120407-11	2019	Brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), hepatocyte growth factor (HGF), and stromal cell-derived factor-1 (SDF-1) gene expressions in hAFS were elevated when exposed to HI-induced brain extract.	Histidine	198-200	brain derived neurotrophic factor	Mus musculus	0-33
30251657-7	2018	NMR data demonstrate that the recombinant domains of THB2 and THB4 coordinate the ferrous heme iron with the proximal histidine and a lysine from the distal helix.	Histidine	118-127	uncharacterized protein	Chlamydomonas reinhardtii	62-66
35630268-4	2022	Cleavage of peptide substrate results in the generation of a copper-binding chelator peptide with a histidine residue in the first or third position (His1 or His3) at the N-terminal.	Histidine	100-109	viral integration site 1	Homo sapiens	150-154
35578055-6	2022	The strong and stable binding of these safe and cheap vitamins at the important residues (R403, K417, Y449, Y453, N501, and Y505) in the S-protein-ACE2 interface and 3CLpro binding site residues especially active site residues (His 41 and Cys 145), indicating that they could be valuable repurpose drugs for inhibiting SARS-CoV-2 entry into the host and replication.	Histidine	228-231	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	137-138
35578055-6	2022	The strong and stable binding of these safe and cheap vitamins at the important residues (R403, K417, Y449, Y453, N501, and Y505) in the S-protein-ACE2 interface and 3CLpro binding site residues especially active site residues (His 41 and Cys 145), indicating that they could be valuable repurpose drugs for inhibiting SARS-CoV-2 entry into the host and replication.	Histidine	228-231	angiotensin converting enzyme 2	Homo sapiens	147-151
11387315-8	2001	To answer this question, we utilized the two previously described mutant forms of PTHR, H401 and H402, which contain a naturally present histidine residue at position 301 in H3 and a second substituted histidine residue at positions 401 and 402 in H6, respectively.	Histidine	202-211	parathyroid hormone like hormone	Homo sapiens	82-86
11531281-0	2001	FHIT (fragile histidine triad) gene analysis in cervical intraepithelial neoplasia.	Histidine	14-23	fragile histidine triad diadenosine triphosphatase	Homo sapiens	0-4
35481649-0	2022	Histidine methyltransferase SETD3 methylates structurally diverse histidine mimics in actin.	Histidine	66-75	SET domain containing 3, actin histidine methyltransferase	Homo sapiens	28-33
30613344-3	2018	When compared with the structure of a mercaptoacetamide bound to the class I isozyme HDAC8, different interactions are observed with the conserved tandem histidine pair in the active site.	Histidine	154-163	histone deacetylase 8	Homo sapiens	85-90
30335802-1	2018	In eukaryotes, the modification of an invariant histidine (His-699 in yeast) residue in translation elongation factor 2 (EF2) with diphthamide involves a conserved pathway encoded by the DPH1-DPH7 gene network.	Histidine	48-57	diphthamide synthase	Saccharomyces cerevisiae S288C	192-196
30335802-1	2018	In eukaryotes, the modification of an invariant histidine (His-699 in yeast) residue in translation elongation factor 2 (EF2) with diphthamide involves a conserved pathway encoded by the DPH1-DPH7 gene network.	Histidine	59-62	diphthamide synthase	Saccharomyces cerevisiae S288C	192-196
35481649-1	2022	Actin histidine Ntau -methylation by histidine methyltransferase SETD3 plays an important role in human biology and diseases.	Histidine	6-15	SET domain containing 3, actin histidine methyltransferase	Homo sapiens	65-70
35481649-2	2022	Here, we report integrated synthetic, biocatalytic, biostructural, and computational analyses on human SETD3-catalyzed methylation of actin peptides possessing histidine and its structurally and chemically diverse mimics.	Histidine	160-169	SET domain containing 3, actin histidine methyltransferase	Homo sapiens	103-108
11531281-1	2001	OBJECTIVE: Recently a candidate tumor suppressor gene, FHIT (fragile histidine triad), was identified at chromosome 3p14.2.	Histidine	69-78	fragile histidine triad diadenosine triphosphatase	Homo sapiens	55-59
35481649-4	2022	Quantum mechanical/molecular mechanical molecular dynamics and free-energy simulations provide insight into binding geometries and the free energy barrier for the enzymatic methyl transfer to histidine mimics, further supporting experimental data that histidine is the superior SETD3 substrate over its analogs.	Histidine	192-201	SET domain containing 3, actin histidine methyltransferase	Homo sapiens	278-283
35481649-5	2022	This work demonstrates that human SETD3 has a potential to catalyze efficient methylation of several histidine mimics, overall providing mechanistic, biocatalytic, and functional insight into actin histidine methylation by SETD3.	Histidine	101-110	SET domain containing 3, actin histidine methyltransferase	Homo sapiens	34-39
30054272-4	2018	The mutation causes a substitution of a glutamine residue that is highly conserved in the extracellular S1-S2 loop of domain II in all Cav channels with a histidine and was identified by whole-exome sequencing of an individual with moderate hearing impairment, developmental delay, and epilepsy.	Histidine	155-164	caveolin 2	Homo sapiens	135-138
35481649-5	2022	This work demonstrates that human SETD3 has a potential to catalyze efficient methylation of several histidine mimics, overall providing mechanistic, biocatalytic, and functional insight into actin histidine methylation by SETD3.	Histidine	101-110	SET domain containing 3, actin histidine methyltransferase	Homo sapiens	223-228
11468363-5	2001	Phosphate binds to the catalytic site of both Ang and Q117G in essentially the same manner observed in the RNase A-phosphate complex, forming hydrogen bonds with the side chains of His 13, His 114, and Gln 12, and the main chain of Leu 115; it makes an additional interaction with the Lys 40 ammonium group in the Ang complex.	Histidine	181-184	angiogenin	Homo sapiens	46-49
35481649-5	2022	This work demonstrates that human SETD3 has a potential to catalyze efficient methylation of several histidine mimics, overall providing mechanistic, biocatalytic, and functional insight into actin histidine methylation by SETD3.	Histidine	198-207	SET domain containing 3, actin histidine methyltransferase	Homo sapiens	34-39
35481649-5	2022	This work demonstrates that human SETD3 has a potential to catalyze efficient methylation of several histidine mimics, overall providing mechanistic, biocatalytic, and functional insight into actin histidine methylation by SETD3.	Histidine	198-207	SET domain containing 3, actin histidine methyltransferase	Homo sapiens	223-228
30048132-3	2018	To better understand ligand-transporter interactions that could improve potency, we developed structural LAT1 models to guide the design of substituted analogues of phenylalanine and histidine.	Histidine	183-192	solute carrier family 7 member 5	Homo sapiens	105-109
11468363-5	2001	Phosphate binds to the catalytic site of both Ang and Q117G in essentially the same manner observed in the RNase A-phosphate complex, forming hydrogen bonds with the side chains of His 13, His 114, and Gln 12, and the main chain of Leu 115; it makes an additional interaction with the Lys 40 ammonium group in the Ang complex.	Histidine	189-192	angiogenin	Homo sapiens	46-49
11461677-4	2001	In addition, NT-3 and NT-4 sequences contained additional substitutions, including asparagine at position 22, lysine at position 77 and histidine at position 110, that were absent in transmitting mother and consensus subtype B sequences.	Histidine	136-145	3'-nucleotidase	Homo sapiens	13-17
11453994-8	2001	The enzymatic activity of purified His-tagged GST T1-1 variants expressed in Escherichia coli was markedly reduced with both dichloromethane and the alternative substrate 1,2-epoxy-3-(4"-nitrophenoxy)propane.	Histidine	35-38	glutathione S-transferase theta 1	Rattus norvegicus	46-52
30073125-6	2018	The caspase family signature histidine active motif H233SAYDCCVVIILSHG247, cysteine active motif K287PKLFFIQACGG298 and pentapeptide "QACGG" active sites present in the p20 domain of Lrcasp9 was conserved across fish species, mouse and human caspase-9.	Histidine	29-38	caspase 9	Homo sapiens	4-11
35487958-3	2022	Limiting phosphate and iron in growth media induced expression of the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein from the P. tricornutum HASP1 promoter in the wild-type strain and in a histidine auxotrophic strain that alleviates the requirement for antibiotic selection of expression plasmids.	Histidine	204-213	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	118-123
35339000-4	2022	The activated caspase-3 and changes of ATPase activity in UMH-treated meat accelerated the postmortem ageing, and L-histidine might competitively inhibit the actin-myosin binding by the imidazole group.	Histidine	114-125	dynein axonemal heavy chain 8	Homo sapiens	39-45
11390663-11	2001	Finally, profiling of a gcn4Delta mutant uncovered an alternative induction pathway operating at many Gcn4p target genes in histidine-starved cells.	Histidine	124-133	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	102-107
29685090-3	2018	Interestingly, SULT2A8 lacks a conservative catalytic His residue at position 99th.	Histidine	54-57	sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 8	Mus musculus	15-22
11683369-1	2001	BACKGROUND: Human FHIT (fragile histidine triad) gene is highly conserved gene homologous to a group of genes identified in prokaryotes and eukaryotes.	Histidine	32-41	fragile histidine triad diadenosine triphosphatase	Homo sapiens	18-22
29914368-3	2018	The ribosomal oxygenases RIOX1 (NO66) and RIOX2 (MINA53) modify ribosomal proteins by histidine hydroxylation.	Histidine	86-95	ribosomal oxygenase 2	Homo sapiens	49-55
29849110-3	2018	In this research we report a FRalpha binding peptide C7(Met-His-Thr-Ala-Pro-Gly-Trp-Gly-Tyr-Arg-Leu-Ser) discovered by phage display and this peptide showed specific binding to FRalpha expressing cells by cell ELISA and flow cytometry.	Histidine	60-63	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	177-184
11439928-8	2001	In contrast, ATP activated a chimera containing the hIK1 C-terminal amino acids His(299)-Lys(427).	Histidine	80-83	potassium calcium-activated channel subfamily N member 4	Homo sapiens	52-56
29844495-6	2018	Structure comparisons identify a TIRR histidine (H106) that is absent from the TIRR homolog Nudt16, but essential for 53BP1 Tudor binding.	Histidine	38-47	tumor protein p53 binding protein 1	Homo sapiens	118-123
11278664-6	2001	His(348) in ST8Sia II and His(331) in ST8Sia IV, respectively) within the sialyl motif VS in all sialyltransferase genes cloned to date.	Histidine	0-3	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	Homo sapiens	38-47
11278664-6	2001	His(348) in ST8Sia II and His(331) in ST8Sia IV, respectively) within the sialyl motif VS in all sialyltransferase genes cloned to date.	Histidine	26-29	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	Homo sapiens	38-47
29436593-2	2018	In the present study, the proliferation of recA-deficient Escherichia coli strains was revealed to be inhibited by 1% L-histidine under aerobic conditions.	Histidine	118-129	DNA recombination/repair protein RecA	Escherichia coli str. K-12 substr. MG1655	43-47
29436593-4	2018	Reverse transcription-quantitative polymerase chain reaction analysis demonstrated that the expression of recA in E. coli MG1655 increased ~7-fold following treatment with 10 mM hydrogen peroxide (H2O2) plus 1% L-histidine, compared with that following exposure to H2O2 alone.	Histidine	211-222	DNA recombination/repair protein RecA	Escherichia coli str. K-12 substr. MG1655	106-110
11278664-7	2001	Mutant ST8Sia II and IV enzymes in which this His residue was changed to Lys showed no detectable enzyme activity, even though they were folded correctly and could bind to CDP-hexanolamine, suggesting the importance of the His residue for their catalytic activity.	Histidine	46-49	cut like homeobox 1	Homo sapiens	172-175
11278668-0	2001	Heparin-binding histidine and lysine residues of rat selenoprotein P.	Histidine	16-25	selenoprotein P	Rattus norvegicus	53-68
11278668-11	2001	The present results indicate that histidine is a constituent of the heparin-binding site of selenoprotein P.	Histidine	34-43	selenoprotein P	Rattus norvegicus	92-107
11278668-12	2001	The presence of histidine, the pK(a) of which is 7.0, explains the release of selenoprotein P from heparin binding as pH rises above 7.0.	Histidine	16-25	selenoprotein P	Rattus norvegicus	78-93
11437244-1	2001	Histidine decarboxylase (HDC) synthesizes endogenous histamine from histidine in mammals.	Histidine	68-77	histidine decarboxylase	Mus musculus	0-23
29402466-3	2018	Most of vertebrate CTR1 proteins contain the His residue in position three from N-terminus, creating a well-known Amino Terminal Cu(II)- and Ni(II)-Binding (ATCUN) site.	Histidine	45-48	solute carrier family 31 member 1	Homo sapiens	19-23
29402466-4	2018	CTR1 from humans, primates and many other species contains the Met-Asp-His (MDH) sequence, while some rodents including mouse have the Met-Asn-His (MNH) N-terminal sequence.	Histidine	71-74	solute carrier family 31 member 1	Homo sapiens	0-4
11437244-1	2001	Histidine decarboxylase (HDC) synthesizes endogenous histamine from histidine in mammals.	Histidine	68-77	histidine decarboxylase	Mus musculus	25-28
11287669-8	2001	In addition, complementation assay and identification of the mutation site of another pleiotropic mutant, cia5, revealed that His-54 within the putative zinc-finger motif of the CCM1 is crucial to its regulatory function.	Histidine	126-129	uncharacterized protein	Chlamydomonas reinhardtii	178-182
29896284-5	2018	Gene set enrichment analysis showed that the high-risk group with lower expression levels of the three genes was enriched in bladder cancer and cell cycle pathway, whereas the low-risk group with higher expression levels of the three genes was enriched in drug metabolism-cytochrome P450, PPAR signaling pathway, fatty acid and histidine metabolisms.	Histidine	328-337	peroxisome proliferator activated receptor alpha	Homo sapiens	289-293
11361146-5	2001	Analysis by site-directed mutagenesis suggested that at least four histidine residues in the C-terminal part of the molecule are essential for the catalytic activity of CAD DNase.	Histidine	67-76	DNA fragmentation factor subunit beta	Homo sapiens	169-172
29642034-6	2018	Substitution of histidine at the cognate position 164 in cTnI confers the same pH insensitivity to adult cardiac myocytes.	Histidine	16-25	troponin I3, cardiac type	Rattus norvegicus	57-61
11092895-2	2001	Analysis of the amino-terminal region of the FILAMENTOUS FLOWER protein suggests that seven cysteine residues at positions 14, 26, 30, 33, 54, 56, and 57, and two histidine residues at positions 18 and 24 contribute to a putative zinc finger motif, Cys-X(3)-His-X(5)-His-X-Cys-X(3)-Cys-X(2)-Cys-X(20)-Cys-X-Cys-Cys.	Histidine	163-172	Plant-specific transcription factor YABBY family protein	Arabidopsis thaliana	45-63
29632894-2	2018	We show how a unique GNAT subfamily member uses a previously unidentified noncanonical catalytic triad, consisting of a glutamic acid, a histidine, and the antibiotic substrate itself, which acts as a nucleophile and attacks the acetyl donor molecule.	Histidine	137-146	glycine-N-acyltransferase like 1	Homo sapiens	21-25
29480716-4	2018	We have engineered histidine into highly solvent accessible positions of UBA(2), creating six single histidine variants.	Histidine	19-28	ubiquitin like modifier activating enzyme 2	Homo sapiens	73-78
29480716-4	2018	We have engineered histidine into highly solvent accessible positions of UBA(2), creating six single histidine variants.	Histidine	101-110	ubiquitin like modifier activating enzyme 2	Homo sapiens	73-78
29480716-6	2018	Furthermore, engineered histidine residues in UBA(2) strongly destabilize the iso-1-cytochrome c domain.	Histidine	24-33	ubiquitin like modifier activating enzyme 2	Homo sapiens	46-51
11092895-2	2001	Analysis of the amino-terminal region of the FILAMENTOUS FLOWER protein suggests that seven cysteine residues at positions 14, 26, 30, 33, 54, 56, and 57, and two histidine residues at positions 18 and 24 contribute to a putative zinc finger motif, Cys-X(3)-His-X(5)-His-X-Cys-X(3)-Cys-X(2)-Cys-X(20)-Cys-X-Cys-Cys.	Histidine	258-261	Plant-specific transcription factor YABBY family protein	Arabidopsis thaliana	45-63
11092895-2	2001	Analysis of the amino-terminal region of the FILAMENTOUS FLOWER protein suggests that seven cysteine residues at positions 14, 26, 30, 33, 54, 56, and 57, and two histidine residues at positions 18 and 24 contribute to a putative zinc finger motif, Cys-X(3)-His-X(5)-His-X-Cys-X(3)-Cys-X(2)-Cys-X(20)-Cys-X-Cys-Cys.	Histidine	267-270	Plant-specific transcription factor YABBY family protein	Arabidopsis thaliana	45-63
11258897-12	2001	Specifically, linkage of acyl-chains to the alpha-amino group of His(1) and replacement of Ala(2) result in significantly increased biological effects of GLP-1 in vivo, likely due to decreased degradation rather than enhanced receptor interactions.	Histidine	65-68	glucagon	Mus musculus	154-159
29590073-3	2018	In the presence of the substrate protein, elongation factor 2, this intermediate converts to an organic radical, formed by addition of the ACP radical to a histidine side chain.	Histidine	156-165	eukaryotic translation elongation factor 2	Homo sapiens	42-61
11341914-0	2001	Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.	Histidine	88-97	homoserine dehydrogenase	Saccharomyces cerevisiae S288C	26-50
29237553-8	2018	However, IL-11 R112H fails to support the survival of osteoclast progenitor cells and is less thermally stable, which is caused by the loss of the positive charge on the protein surface since protonation of the histidine side chain recovers stability.	Histidine	211-220	interleukin 11	Homo sapiens	9-14
11341914-6	2001	UV difference spectra revealed an increase in absorbance at 240 nm for DEPC-modified HSD consistent with the modification of two histidines (His) per subunit.	Histidine	129-139	homoserine dehydrogenase	Saccharomyces cerevisiae S288C	85-88
11341914-6	2001	UV difference spectra revealed an increase in absorbance at 240 nm for DEPC-modified HSD consistent with the modification of two histidines (His) per subunit.	Histidine	141-144	homoserine dehydrogenase	Saccharomyces cerevisiae S288C	85-88
11341914-7	2001	Amino acid sequence alignment of HSD illustrated the conservation of two His residues among HSDs.	Histidine	73-76	homoserine dehydrogenase	Saccharomyces cerevisiae S288C	33-36
11133756-2	2001	This interaction involves the A1 domain of vWF and the N-terminal extracellular region of GP Ibalpha (His-1-Glu-282), and it can also be induced under static conditions by the modulators ristocetin and botrocetin.	Histidine	102-105	von Willebrand factor	Cricetulus griseus	43-46
29020666-3	2018	Herein, we describe a simple histidine (H) conjugated perylene diimide (PDI) bolaamphiphile (HPH) as a dual-responsive optical marker to develop highly selective and sensitive probe as visible (sol-to-gel transformation), fluorescence and SERS-based Hg2+sensor platform in the water.	Histidine	29-38	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	239-243
29224352-1	2018	The proton-coupled oligopeptide transporter PHT1 (SLC15A4), which facilitates cross-membrane transport of histidine and small peptides from inside the endosomes or lysosomes to cytosol, plays an important role in intracellular peptides homeostasis and innate immune responses.	Histidine	106-115	solute carrier family 15 member 4	Homo sapiens	44-48
29224352-1	2018	The proton-coupled oligopeptide transporter PHT1 (SLC15A4), which facilitates cross-membrane transport of histidine and small peptides from inside the endosomes or lysosomes to cytosol, plays an important role in intracellular peptides homeostasis and innate immune responses.	Histidine	106-115	solute carrier family 15 member 4	Homo sapiens	50-57
12120225-1	2001	BACKGROUND/AIMS: This study attempts to identify the biochemical alterations in human cationic trypsinogen and trypsin caused by the hereditary pancreatitis-associated mutations Arg117--&gt;His and Asn21--&gt;Ile.	Histidine	190-193	serine protease 1	Homo sapiens	86-106
30296200-0	2018	Expression, purification, and characterization of N-terminal His-tagged proteins with mutations in zinc finger 3 of zinc finger protein ZNF191(243-368).	Histidine	61-64	zinc finger protein 24	Homo sapiens	136-142
11095676-3	2000	Bas1p is a Myb-related transcription factor that acts together with the homeodomain-related Bas2p (Pho2p) to regulate purine and histidine biosynthesis genes in response to extracellular purine limitation.	Histidine	129-138	Bas1p	Saccharomyces cerevisiae S288C	0-5
29148740-2	2017	Iso-1-cytochrome c variants with a Lys54   His mutation form a particularly stable His-heme loop in the denatured state, suggestive of loop-induced residual structure.	Histidine	43-46	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	0-5
28724665-4	2017	Tumor-associated macrophages in surgical specimens and sensitivity to CSF-1R inhibitors were used to determine macrophage function.Results: A CSF1R c.1085A&gt;G genetic variant causing the change of histidine to arginine in the domain of receptor dimerization was identified as a high allele frequency in Eastern Asian population.	Histidine	199-208	colony stimulating factor 1	Homo sapiens	142-146
11169249-2	2000	Both alleles differ from DPB1*0402 by a single nucleotide: DPB1*8201 has a difference at position 359 (codon 91) leading to an amino acid change from arg to his, making this position a new polymorphic site; DPB1*8301 has a difference at position 280 (codon 65) changing the amino acid from ile to phe.	Histidine	157-160	major histocompatibility complex, class II, DP beta 1	Homo sapiens	25-29
28952923-0	2017	A Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1.	Histidine	2-11	RAS guanyl releasing protein 1	Homo sapiens	98-105
28724772-2	2017	Two-hybrid and pulldown assays demonstrated that UL20, but no other HSV-1 gene-encoded proteins, binds specifically to GODZ (also known as DHHC3), a cellular Golgi apparatus-specific Asp-His-His-Cys (DHHC) zinc finger protein.	Histidine	187-190	zinc finger DHHC-type palmitoyltransferase 3	Homo sapiens	119-123
11169249-2	2000	Both alleles differ from DPB1*0402 by a single nucleotide: DPB1*8201 has a difference at position 359 (codon 91) leading to an amino acid change from arg to his, making this position a new polymorphic site; DPB1*8301 has a difference at position 280 (codon 65) changing the amino acid from ile to phe.	Histidine	157-160	major histocompatibility complex, class II, DP beta 1	Homo sapiens	59-63
11169249-2	2000	Both alleles differ from DPB1*0402 by a single nucleotide: DPB1*8201 has a difference at position 359 (codon 91) leading to an amino acid change from arg to his, making this position a new polymorphic site; DPB1*8301 has a difference at position 280 (codon 65) changing the amino acid from ile to phe.	Histidine	157-160	major histocompatibility complex, class II, DP beta 1	Homo sapiens	59-63
11029294-12	2000	Combined mutations of the lysine and histidine residues in Kir4.1 (K53V/S328H/G340H) gave rise to a channel that had CO(2)/pH sensitivities almost identical to those of the wild-type Kir1.1.	Histidine	37-46	potassium inwardly rectifying channel subfamily J member 1	Homo sapiens	183-189
28882106-6	2017	By utilizing plasmid flag-p27kip1, HA-RanBP2, GST-RanBP2 and His-p27kip1 and immunoprecipitation assay, we validated that p27kip1 can serve as the sumoylation target of RanBP2 in QBC939.	Histidine	61-64	cyclin dependent kinase inhibitor 1B	Homo sapiens	65-72
11062153-9	2000	Cloning and sequencing of SULT1A1 cDNA from MCF-7 cells revealed that mRNAs encoding two previously identified allelic variants, SULT1A1*1 ((213)Arg) and SULT1A1*2 ((213)His), were expressed in these cells.	Histidine	170-173	sulfotransferase family 1A member 1	Homo sapiens	26-33
28882106-6	2017	By utilizing plasmid flag-p27kip1, HA-RanBP2, GST-RanBP2 and His-p27kip1 and immunoprecipitation assay, we validated that p27kip1 can serve as the sumoylation target of RanBP2 in QBC939.	Histidine	61-64	cyclin dependent kinase inhibitor 1B	Homo sapiens	65-72
11083248-2	2000	Because expression of Cx40 occurs predominantly in the atria and His-Purkinje system of the mouse heart, the AV conduction disturbances were thought to be secondary to disruption in His-Purkinje function.	Histidine	65-68	gap junction protein, alpha 5	Mus musculus	22-26
28592540-8	2017	Importantly, the covalent coupling not only enhanced gp120-directed responses compared to soluble trimers, it also completely eliminated antibodies directed to the C-terminal His tag located at the "bottom" of the spike.	Histidine	175-178	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	53-58
28425671-6	2017	Importantly, the endogenous proteasomal E3 ligase UBE3C was also successfully labelled by Ub-PA and His-UBE2D2-Ub-ABP in lysate of cells grown under basal conditions.	Histidine	100-103	ubiquitin conjugating enzyme E2 D2	Homo sapiens	104-110
11083248-2	2000	Because expression of Cx40 occurs predominantly in the atria and His-Purkinje system of the mouse heart, the AV conduction disturbances were thought to be secondary to disruption in His-Purkinje function.	Histidine	182-185	gap junction protein, alpha 5	Mus musculus	22-26
11083248-8	2000	CONCLUSION: Cx40-deficient mice exhibit significant delay not only in infra-Hisian conduction, as would be expected from the expression of Cx40 in the His-Purkinje system but also in the electrophysiologic parameters that reflect AV nodal conduction.	Histidine	76-79	gap junction protein, alpha 5	Mus musculus	12-16
28500133-7	2017	Furthermore, as measured in a co-immunoprecipitation assay, substitution of the His or Cys heme ligands in Rev-erbbeta was accompanied by a significant loss of NCoR1 binding.	Histidine	80-83	nuclear receptor corepressor 1	Homo sapiens	160-165
11021840-3	2000	In this study we demonstrate that rDsg3-Ig-His adsorbs out autoantibodies to different keratinocyte antigens, including a non-Dsg 3 130-kd polypeptide.	Histidine	43-46	desmoglein 3	Rattus norvegicus	34-39
28387856-0	2017	Involvement of C-Terminal Histidines in Soybean PM1 Protein Oligomerization and Cu2+ Binding.	Histidine	26-36	late embryogenesis abundant group 4 protein PM1	Glycine max	48-51
28387856-7	2017	When the histidine residues in PM1 and PM1-C were chemically modified, oligomerization was abolished, suggesting that histidines play a key role in this process.	Histidine	9-18	late embryogenesis abundant group 4 protein PM1	Glycine max	31-34
11046183-2	2000	Cx40 is solely expressed in the atrium and His-Purkinje system.	Histidine	43-46	gap junction protein, alpha 5	Mus musculus	0-4
28387856-7	2017	When the histidine residues in PM1 and PM1-C were chemically modified, oligomerization was abolished, suggesting that histidines play a key role in this process.	Histidine	9-18	late embryogenesis abundant group 4 protein PM1	Glycine max	39-42
28387856-7	2017	When the histidine residues in PM1 and PM1-C were chemically modified, oligomerization was abolished, suggesting that histidines play a key role in this process.	Histidine	118-128	late embryogenesis abundant group 4 protein PM1	Glycine max	31-34
28387856-7	2017	When the histidine residues in PM1 and PM1-C were chemically modified, oligomerization was abolished, suggesting that histidines play a key role in this process.	Histidine	118-128	late embryogenesis abundant group 4 protein PM1	Glycine max	39-42
10985794-3	2000	It was used with mitochondria isolated from genetically modified strains of Saccharomyces cerevisiae, producing the native or the His-tagged Anc2p isoform of the carrier.	Histidine	130-133	ADP/ATP carrier protein PET9	Saccharomyces cerevisiae S288C	141-146
28270603-3	2017	In Arabidopsis thaliana accession Cvi-0, one of the two copies of a duplicated histidine biosynthesis gene, HISN6A, is mutated, making HISN6B essential.	Histidine	79-88	histidinol phosphate aminotransferase 1	Arabidopsis thaliana	108-114
28328125-1	2017	De novo heterozygous mutations changing R179 to histidine, leucine, or cysteine in the ACTA2 gene are associated with Multisystemic Smooth Muscle Dysfunction Syndrome (MSMDS).	Histidine	48-57	actin alpha 2, smooth muscle	Homo sapiens	87-92
10871611-6	2000	Mutations of two additional histidines (His-138 and His-151), conserved only in eukaryotes, resulted in reduced neutral sphingomyelinase activity.	Histidine	28-38	sphingomyelin phosphodiesterase 2	Homo sapiens	112-136
27665193-4	2017	The SERS results for BN and its fragment demonstrated that (1) three amino acids from these peptides sequence; i.e., l-histidine, l-methionine, and l-tryptophan, are involved in the interaction with gold coated silicon wafer and (2) the strength of these interactions depends upon the aforementioned amino acids position in the peptide sequence.	Histidine	117-128	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	4-8
10871611-6	2000	Mutations of two additional histidines (His-138 and His-151), conserved only in eukaryotes, resulted in reduced neutral sphingomyelinase activity.	Histidine	40-43	sphingomyelin phosphodiesterase 2	Homo sapiens	112-136
10871611-6	2000	Mutations of two additional histidines (His-138 and His-151), conserved only in eukaryotes, resulted in reduced neutral sphingomyelinase activity.	Histidine	52-55	sphingomyelin phosphodiesterase 2	Homo sapiens	112-136
10964674-2	2000	In this study, the mutant protein L325H, which replaced a leucine 325 of the glutamate transporter EAAT1 by a histidine, was evaluated.	Histidine	110-119	solute carrier family 1 member 3 L homeolog	Xenopus laevis	99-104
27895090-3	2017	Here, we assessed roles for six histidine residues for which either genetic or structural data suggested a possible role in the acid-responsiveness of the LDLR.	Histidine	32-41	low density lipoprotein receptor	Homo sapiens	155-159
10951567-5	2000	Mutating W342 to aspartate (D), lysine (K) or histidine (H) also inactivated c-Raf whether assayed as a purified immunoprecipitate or when recruited to the plasma membrane.	Histidine	46-55	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	77-82
27640900-3	2017	The current study demonstrated that the amino acids histidine, lysine, threonine inhibited mTOR signaling and IgE-mediated mast cell activation, while the amino acids leucine, isoleucine, valine had no effect on mTOR signaling in BMMCs.	Histidine	52-61	mechanistic target of rapamycin kinase	Mus musculus	91-95
10764784-5	2000	Surprisingly, in the presence of Mg-ADP, GroES was able to cap the GroEL-alphabeta complex in cis, despite the size of 86 kDa of the heterodimer (with a His(6) tag and a linker).	Histidine	153-156	heat shock protein family E (Hsp10) member 1	Homo sapiens	41-46
27923678-3	2017	The C-terminal cytosolic domain of mitoNEET hosts a redox active [2Fe-2S] cluster via three cysteine and one histidine residues.	Histidine	109-118	CDGSH iron sulfur domain 1	Homo sapiens	35-43
10908805-2	2000	In this report, a C-terminal histidine-tagged cationic peanut peroxidase gene was expressed in transgenic tobacco (Nicotiana tabacum).	Histidine	29-38	peroxidase N1-like	Nicotiana tabacum	62-72
27934216-5	2016	Here, we combine various biophysical methods to explore the interaction between this Ctr1 segment and metallochaperone Atox1 and clearly demonstrate that the Ctr1 intracellular loop (1) can coordinate Cu(I) via interactions with the side chains of one histidine and two methionine residues and (2) closely interacts with the Atox1 metallochaperone.	Histidine	252-261	solute carrier family 31 member 1	Homo sapiens	85-89
27934216-5	2016	Here, we combine various biophysical methods to explore the interaction between this Ctr1 segment and metallochaperone Atox1 and clearly demonstrate that the Ctr1 intracellular loop (1) can coordinate Cu(I) via interactions with the side chains of one histidine and two methionine residues and (2) closely interacts with the Atox1 metallochaperone.	Histidine	252-261	solute carrier family 31 member 1	Homo sapiens	158-162
28096792-1	2016	Haemoglobin (Hb)-M Hyde Park, also known as Hb-M Akita is a rare type of hereditary Hb M due to autosomal dominant mutation of CAC&gt;TAC on codon 92 of beta globin gene resulting in the replacement of histidine by tyrosine on beta globin chain.	Histidine	202-211	hemoglobin subunit beta	Homo sapiens	153-164
10861226-6	2000	Here we describe the expression of a 6 x His-tagged rat L-CPT I in Pichia pastoris and purification of the detergent-solubilized enzyme in milligram quantities.	Histidine	41-44	carnitine palmitoyltransferase 1B	Rattus norvegicus	58-63
27374989-8	2016	We suggest that Dm eIF4E-3 and Dm eIF4E-5 bind the second nucleoside of the cap in an unusual manner via stacking interactions with a histidine or a phenylalanine residue, respectively.	Histidine	134-143	eukaryotic translation initiation factor 4E3	Drosophila melanogaster	19-26
10861226-16	2000	Second, the kinetics of the reconstituted, 6 x His-tagged L-CPT I with regard to substrate and pH responses were similar to what is observed with rat liver mitochondria (whereas in P. pastoris mitochondria the enzyme behaved anomalously), confirming that the purified preparation is a suitable model for studying the functional properties of the enzyme.	Histidine	47-50	carnitine palmitoyltransferase 1B	Rattus norvegicus	60-65
10937063-1	2000	The fragile histidine triad (FHIT) protein is a suspected tumor-suppressor gene frequently expressed in adenocarcinomas of the lung and other organs.	Histidine	12-21	fragile histidine triad diadenosine triphosphatase	Homo sapiens	29-33
27553280-8	2016	The peptide/histidine transporter 1 (PHT1) was highly expressed in both myoblasts and myotubes, and co-administration of histidine inhibited Hyp-Gly-induced phosphorylation of p70S6K in myoblasts and myotubes.	Histidine	12-21	solute carrier family 15 member 4	Homo sapiens	37-41
27553280-8	2016	The peptide/histidine transporter 1 (PHT1) was highly expressed in both myoblasts and myotubes, and co-administration of histidine inhibited Hyp-Gly-induced phosphorylation of p70S6K in myoblasts and myotubes.	Histidine	12-21	ribosomal protein S6 kinase B1	Homo sapiens	176-182
27588329-9	2016	The complex structure of cyt c meant that this reactant was represented solely by the heme group including the chiral axial ligands L-His and L-Met.	Histidine	132-137	cytochrome c, somatic	Equus caballus	25-30
10825448-0	2000	Diethyl pyrocarbonate inactivates CD39/ecto-ATPDase by modifying His-59.	Histidine	65-68	tripartite motif containing 33	Homo sapiens	39-43
27373844-7	2016	We also identified a region of MGAT2 associated with the ER membrane that contains the histidine-proline-histidine-glycine sequence present in all DGAT2 family members that is thought to comprise the active site.	Histidine	87-96	diacylglycerol O-acyltransferase 2	Homo sapiens	147-152
10825448-6	2000	Comparison of known sequences of CD39-like ecto-ATP(D)ases with the results on inactivation by DEPC revealed His-59 and His-251 (according to the human CD39 sequence) as equally possible targets of the inactivating DEPC modification.	Histidine	109-112	tripartite motif containing 33	Homo sapiens	43-47
27416303-7	2016	A mutant form of PAI-1 lacking two N-terminal histidine residues at positions 2 and 3 exhibits similar increases in dynamics upon Cu(II) binding compared to that of active wild-type PAI-1, indicating that the observed structural effects are not a result of coordination of Cu(II) to these histidine residues.	Histidine	46-55	serpin family E member 1	Homo sapiens	17-22
10825448-6	2000	Comparison of known sequences of CD39-like ecto-ATP(D)ases with the results on inactivation by DEPC revealed His-59 and His-251 (according to the human CD39 sequence) as equally possible targets of the inactivating DEPC modification.	Histidine	120-123	tripartite motif containing 33	Homo sapiens	43-47
10856480-7	2000	RESULT(S): Two different mutations were detected on CYP17: One was a deletion of the phenylalanine codon (TTC) at either amino acid 53 or 54 in exon 1, and the other was a missense mutation with the substitution of histidine (CAC) by leucine (CTC) at position 373 in exon 6.	Histidine	215-224	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	52-57
27284008-5	2016	All four sdAb-Fcs recognize the C-terminal Cys-His-rich domain of PCSK9.	Histidine	47-50	proprotein convertase subtilisin/kexin type 9	Homo sapiens	66-71
10747932-6	2000	These analyses identified a subset of cysteine and histidine residues required for stimulation of late gene expression, physical interaction with E1b 55k, and p53 destabilization.	Histidine	51-60	branched chain keto acid dehydrogenase E1 subunit beta	Homo sapiens	146-149
10893046-10	2000	CONCLUSIONS: L-Histidine uptaken by rat BMEC was shown to be converted to histamine, suggesting that HDC plays an important role in BBB.	Histidine	13-24	histidine decarboxylase	Rattus norvegicus	101-104
27380437-3	2016	Histidine and citrate buffers with/without sodium chloride were employed to modulate the mAb"s conformational stability, solubility (in the presence of polyethylene glycol, PEG), and protein-protein interactions as measured by differential scanning calorimetry, PEG precipitation, and static light scattering, respectively.	Histidine	0-9	progestagen associated endometrial protein	Homo sapiens	173-176
27380437-3	2016	Histidine and citrate buffers with/without sodium chloride were employed to modulate the mAb"s conformational stability, solubility (in the presence of polyethylene glycol, PEG), and protein-protein interactions as measured by differential scanning calorimetry, PEG precipitation, and static light scattering, respectively.	Histidine	0-9	progestagen associated endometrial protein	Homo sapiens	262-265
10766788-0	2000	Identification of the proximal ligand His-20 in heme oxygenase (Hmu O) from Corynebacterium diphtheriae.	Histidine	38-41	biliverdin-producing heme oxygenase	Corynebacterium diphtheriae	48-62
27467577-3	2016	Recently, specific non-conserved histidines on human TLR4 have been shown activated by cobalt and nickel ions in solution.	Histidine	33-43	toll like receptor 4	Homo sapiens	53-57
28164627-1	2016	BACKGROUND: Fragile histidine triad (FHIT), fibronectin (FN), and phosphatase and tensin homology deleted on chromosome ten (PTEN) are widely reported as having abnormal expression in malignant tumors.	Histidine	20-29	phosphatase and tensin homolog	Homo sapiens	125-129
27560991-9	2016	Among the amino acids tested (all in L configuration), arginine, lysine, tryptophan and histidine enhanced residual activity of rCA1 and rCA4.	Histidine	88-97	carbonic anhydrase 1	Rattus norvegicus	128-132
10766788-7	2000	Based on sequence identity with the mammalian enzymes the proximal ligand in HO-1 (His-25) and HO-2 (His-45) is conserved (His-20) in the bacterial enzyme.	Histidine	83-86	heme oxygenase 2	Homo sapiens	95-99
10766788-7	2000	Based on sequence identity with the mammalian enzymes the proximal ligand in HO-1 (His-25) and HO-2 (His-45) is conserved (His-20) in the bacterial enzyme.	Histidine	101-104	heme oxygenase 2	Homo sapiens	95-99
10766788-7	2000	Based on sequence identity with the mammalian enzymes the proximal ligand in HO-1 (His-25) and HO-2 (His-45) is conserved (His-20) in the bacterial enzyme.	Histidine	101-104	heme oxygenase 2	Homo sapiens	95-99
27834323-1	2016	BACKGROUND &amp; OBJECTIVES: CNDP1 gene, present on chromosome 18q22.3-23, encodes carnosinase, the rate-limiting enzyme in hydrolysis of carnosine to ss-alanine and L-histidine.	Histidine	166-177	carnosine dipeptidase 1	Homo sapiens	29-34
10985924-7	2000	If DA was not removed, [3-Me-His(2)]-TRH was ineffective.	Histidine	29-32	thyrotropin releasing hormone	Homo sapiens	37-40
27239044-4	2016	Histamine reduction is most likely caused by increased catabolism of the histamine precursor histidine, triggered by rerouting of alanine flux from AGT to the glutamic-pyruvate transaminase (GPT, also known as the alanine-transaminase ALT).	Histidine	93-102	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	148-151
27239044-5	2016	Alanine administration reduces histamine levels in wild-type mice, while overexpression of GPT in PH1 mice increases plasma histidine, normalizes histamine levels, restores vascular permeability, and decreases urinary oxalate levels.	Histidine	124-133	glutamic pyruvic transaminase, soluble	Mus musculus	91-94
27239044-5	2016	Alanine administration reduces histamine levels in wild-type mice, while overexpression of GPT in PH1 mice increases plasma histidine, normalizes histamine levels, restores vascular permeability, and decreases urinary oxalate levels.	Histidine	124-133	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	98-101
10698688-0	2000	Histidine to aspartate phosphotransferase activity of nm23 proteins: phosphorylation of aldolase C on Asp-319.	Histidine	0-9	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	54-58
27082999-7	2016	We constructed two express vector pET28a-His-Hsp65-6P277 and pET28a-His-Hsp65-6IA2P2.	Histidine	41-44	heat shock protein 1 (chaperonin)	Mus musculus	45-50
27082999-7	2016	We constructed two express vector pET28a-His-Hsp65-6P277 and pET28a-His-Hsp65-6IA2P2.	Histidine	68-71	heat shock protein 1 (chaperonin)	Mus musculus	72-77
27082999-10	2016	In conclusion, we suggested that fusion protein His-Hsp65-6IA2P2 could be reconstructed and purified successively.	Histidine	48-51	heat shock protein 1 (chaperonin)	Mus musculus	52-57
10698688-2	2000	We have previously described the transfer of phosphate from the catalytic histidine residues of nm23 proteins to an aspartic or a glutamic residue on one or more 43 kDa proteins in detergent extracts of bovine brain membranes.	Histidine	74-83	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	96-100
10698688-8	2000	The sequence around Asp-319 of aldolase C has some similarities to those around the histidine residues on ATP-citrate lyase and succinic thiokinase that are phosphorylated by nm23 proteins.	Histidine	84-93	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	175-179
26994138-0	2016	Structural Studies of Medicago truncatula Histidinol Phosphate Phosphatase from Inositol Monophosphatase Superfamily Reveal Details of Penultimate Step of Histidine Biosynthesis in Plants.	Histidine	155-164	bifunctional phosphatase IMPL2, chloroplastic	Medicago truncatula	80-104
10684817-1	2000	In the brain of all vertebrate classes, chicken (c) GnRH-II ([His(5), Trp(7),Tyr(8)]GnRH, cGnRH-II) is expressed in the mesencephalon.	Histidine	62-65	gonadotropin releasing hormone 1	Homo sapiens	52-56
10762004-12	2000	The same was observed for the haplotype SULT1A1*His/SULT1A2*Thr, whose frequency was 0.35.	Histidine	48-51	sulfotransferase family 1A member 1	Homo sapiens	40-47
25693639-3	2016	The protonation of histidines in the sequence of [D]-H6L9 under pH 6.3 could switch the surface charge of D-Lip from negative (under pH 7.4) to positive (under pH 6.3), and the cellular uptake and tumor spheroids uptake were increased accordingly.	Histidine	19-29	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	108-111
10762004-12	2000	The same was observed for the haplotype SULT1A1*His/SULT1A2*Thr, whose frequency was 0.35.	Histidine	48-51	sulfotransferase family 1A member 2	Homo sapiens	52-59
10681426-1	2000	We determined the structure of the photolytic intermediate of a sperm whale myoglobin (Mb) mutant called Mb-YQR [Leu-(B10)--&gt;Tyr; His(E7)--&gt;Gln; Thr(E10)--&gt;Arg] to 1.4-A resolution by ultra-low temperature (20 K) x-ray diffraction.	Histidine	133-136	myoglobin	Physeter catodon	76-85
27018888-3	2016	Here, we use activity-based profiling to discover that the poorly characterized multipass transmembrane proteins AIG1 and ADTRP are atypical hydrolytic enzymes that depend on conserved threonine and histidine residues for catalysis.	Histidine	199-208	androgen induced 1	Homo sapiens	113-117
27018888-3	2016	Here, we use activity-based profiling to discover that the poorly characterized multipass transmembrane proteins AIG1 and ADTRP are atypical hydrolytic enzymes that depend on conserved threonine and histidine residues for catalysis.	Histidine	199-208	androgen dependent TFPI regulating protein	Homo sapiens	122-127
10675384-2	2000	The fragile histidine triad (FHIT) gene at chromosome region 3p14.2 is a candidate tumor suppressor gene that may play a role in cervical tumorigenesis.	Histidine	12-21	fragile histidine triad diadenosine triphosphatase	Homo sapiens	29-33
26773745-4	2016	In this study we used an optimized codon sequence to overexpress histidine-tagged human KAT2 (hKAT2) using an Escherichia coli expression system.	Histidine	65-74	aminoadipate aminotransferase	Homo sapiens	88-92
26773745-4	2016	In this study we used an optimized codon sequence to overexpress histidine-tagged human KAT2 (hKAT2) using an Escherichia coli expression system.	Histidine	65-74	aminoadipate aminotransferase	Homo sapiens	94-99
26792558-4	2016	The functionality and validity of the nickel magnetic nanoparticles were attested by purification of three different bioactive His-tagged recombinant fusion proteins including hIGF-1, GM-CSF and bFGF.	Histidine	127-130	colony stimulating factor 2	Homo sapiens	184-190
10672909-4	2000	DPP IV requires an intact alpha-amino-group of the N-terminal histidine of GLP-1 in order to perform its enzymatic activity.	Histidine	62-71	dipeptidylpeptidase 4	Rattus norvegicus	0-6
27035963-9	2016	Modeling based on recent crystal structures, along with mutational analysis, suggests that each subunit within a TREK1-TREK2 channel is regulated independently via titratable His.	Histidine	175-178	potassium two pore domain channel subfamily K member 10	Homo sapiens	119-124
10631090-0	2000	Histidine modifying agents abolish pyruvate dehydrogenase kinase activity.	Histidine	0-9	pyruvate dehydrogenase kinase	Arabidopsis thaliana	35-64
26867578-9	2016	A comparison with the PIG-L deacetylases led to a proposed mechanism for GalB wherein Glu-48 positions and activates the metal-ligated water for the hydration reaction and His-164 acts as a catalytic acid.	Histidine	172-175	phosphatidylinositol glycan anchor biosynthesis class L	Sus scrofa	22-27
10620501-6	2000	A 12-residue spacer, Thr-Arg-His-Arg-Gln-Pro-Arg-Gly-Trp-Glu-Gln-Leu, containing the recognition site for the protease furin, was incorporated between the toxin and the ligand to generate restrictocin-spacer-anti-TFR(scFv) and anti-TFR(scFv)-spacer-restrictocin.	Histidine	29-32	furin, paired basic amino acid cleaving enzyme	Homo sapiens	119-124
26925779-6	2016	In particular, a functionally critical STK-conserved histidine that stabilizes the regulatory spine in STKs is selectively mutated to an alanine, serine or glutamate in PTKs, and this loss-of-function mutation is accommodated, in part, through compensatory PTK-specific interactions in the core.	Histidine	53-62	protein tyrosine kinase 2 beta	Homo sapiens	169-172
26925779-7	2016	In particular, a PTK-conserved phenylalanine in the I-helix appears to structurally and functionally compensate for the loss of STK-histidine by interacting with the regulatory spine, which has far-reaching effects on enzyme activity, inhibitor sensing, and stability.	Histidine	132-141	protein tyrosine kinase 2 beta	Homo sapiens	17-20
10646844-1	2000	Abnormal expression of the fragile histidine triad (FHIT) candidate tumor suppressor gene has been observed in a variety of human tumors, but little is known about its expression during colorectal tumorigenesis.	Histidine	35-44	fragile histidine triad diadenosine triphosphatase	Homo sapiens	52-56
26551063-1	2016	The copper-gonadotropin-releasing hormone molecule (Cu-GnRH) is a GnRH analog, which preserves its amino acid sequence, but which contains a Cu(2+) ion stably bound to the nitrogen atoms including that of the imidazole ring of Histidine(2).	Histidine	227-236	gonadotropin releasing hormone 1	Rattus norvegicus	55-59
10701841-6	2000	Therefore, both GST-SStp and His-S-SStp can be used as affinity-tagged substrates to study prokaryotic chaperone/transit peptide interactions as well as to provide a novel functional probe to study the dynamics of DnaK/DnaJ/GrpE interactions in vivo.	Histidine	29-32	GrpE like 1, mitochondrial	Homo sapiens	224-228
27132720-6	2016	Molecular docking study reveals the selectivity of these molecules towards ALDH1A1 (PDB: 4WP7) and important binding residues (GLY 125, 458; THR 129; TRP 178; TYR 297; PHE 171, 466; VAL 174, 460; MET 175; HIS 293 etc.)	Histidine	205-208	aldehyde dehydrogenase 1 family member A1	Homo sapiens	75-82
10668803-1	2000	Rpb5-H147R is an AT-GC transition replacing CAC(His) by CGC(Arg) at a conserved and critical position of ABC27 (Rpb5p), one of the five common and essential subunits shared by all three eukaryotic RNA polymerases.	Histidine	48-51	RNA polymerase II, I and III subunit E	Homo sapiens	0-4
26596869-7	2015	By conducting pepsin digestion, amino-acid specific chemical modifications, peptide mapping, and measuring the effects of elution residence time, a histidine in the variable fragment (Fab) was identified to be the root cause.	Histidine	148-157	FA complementation group B	Homo sapiens	184-187
10668803-1	2000	Rpb5-H147R is an AT-GC transition replacing CAC(His) by CGC(Arg) at a conserved and critical position of ABC27 (Rpb5p), one of the five common and essential subunits shared by all three eukaryotic RNA polymerases.	Histidine	48-51	RNA polymerase II, I and III subunit E	Homo sapiens	112-117
26104663-8	2015	Sequence analysis showed the mutation in LDD731 caused a histidine-to-tyrosine substitution of the amino acid codon 382 within the RING finger domain of c-Cbl.	Histidine	57-66	Cbl proto-oncogene	Homo sapiens	153-158
10608884-5	1999	N-SMase activity in cells overexpressing the protein with hexa-histidine tag was immunoprecipitated with anti-hexa-histidine antibody.	Histidine	63-72	sphingomyelin phosphodiesterase 2	Homo sapiens	0-7
26402434-4	2015	Rat GLUT4 containing FLAG and His tags at the amino and carboxy termini, respectively, was engineered and stably transfected into HEK-293 cells.	Histidine	30-33	solute carrier family 2 member 4	Rattus norvegicus	4-9
10608884-5	1999	N-SMase activity in cells overexpressing the protein with hexa-histidine tag was immunoprecipitated with anti-hexa-histidine antibody.	Histidine	115-124	sphingomyelin phosphodiesterase 2	Homo sapiens	0-7
10601249-4	1999	In CCS the fourth histidine is replaced by an aspartate (Asp(200)).	Histidine	18-27	copper chaperone for superoxide dismutase	Homo sapiens	3-6
26183761-9	2015	To identify the location of the acid-induced inhibition, mutations were made on each of all histidine residues in cytoplasmic part of ANO1.	Histidine	92-101	anoctamin 1	Homo sapiens	134-138
10606511-4	1999	It reveals that residues Gln-14, His-15, Lys-38, Thr-42, and His-128 at the active site are conserved as in all other RNase A homologues.	Histidine	33-36	ribonuclease A family member 1, pancreatic	Homo sapiens	118-125
26329791-3	2015	To test this, recombinant UGT1A4-P24T, with a C-terminal His-tag, was expressed in sf9 insect cells and affinity-purified for N-terminal protein sequencing.	Histidine	57-60	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	26-32
10606511-4	1999	It reveals that residues Gln-14, His-15, Lys-38, Thr-42, and His-128 at the active site are conserved as in all other RNase A homologues.	Histidine	61-64	ribonuclease A family member 1, pancreatic	Homo sapiens	118-125
10585483-4	1999	ArcB is a tripartite kinase, possessing a primary transmitter, a receiver, and a secondary transmitter domain that catalyzes the phosphorylation of ArcA via a His --&gt; Asp --&gt; His --&gt; Asp phosphorelay, as well as the dephosphorylation of ArcA-P by a reverse phosphorelay.	Histidine	159-162	arginine deiminase	Escherichia coli	148-152
10585483-4	1999	ArcB is a tripartite kinase, possessing a primary transmitter, a receiver, and a secondary transmitter domain that catalyzes the phosphorylation of ArcA via a His --&gt; Asp --&gt; His --&gt; Asp phosphorelay, as well as the dephosphorylation of ArcA-P by a reverse phosphorelay.	Histidine	159-162	arginine deiminase	Escherichia coli	246-250
26668776-1	2015	L-type amino acid transporter 1 (LAT1) is an L-type amino acid transporter and transports large neutral amino acids such as leucine, isoleucine, valine, phenylalanine, tyrosine, tryptophan, methionine, and histidine.	Histidine	206-215	solute carrier family 7 member 5	Homo sapiens	0-31
26668776-1	2015	L-type amino acid transporter 1 (LAT1) is an L-type amino acid transporter and transports large neutral amino acids such as leucine, isoleucine, valine, phenylalanine, tyrosine, tryptophan, methionine, and histidine.	Histidine	206-215	solute carrier family 7 member 5	Homo sapiens	33-37
10632340-1	1999	Loss or reduced expression of the fragile histidine triad (FHIT) gene, a tumor suppressor gene localized at chromosome 3p14.2, is common in several solid and hematological cancers and has been associated with tumor progression and worse prognosis.	Histidine	42-51	fragile histidine triad diadenosine triphosphatase	Homo sapiens	59-63
25923177-12	2015	A shampoo and conditioner containing chelants (EDDS in shampoo and histidine in conditioner) is shown to reduce copper uptake from tap water and reduce protein loss and formation of S100A3 protein fragment.	Histidine	67-76	S100 calcium binding protein A3	Homo sapiens	182-188
10497298-3	1999	Hint-related proteins, found in all forms of life, and fragile histidine triad (Fhit)-related proteins, found in animals and fungi, represent the two main branches of the HIT superfamily.	Histidine	63-72	fragile histidine triad diadenosine triphosphatase	Homo sapiens	80-84
26340532-4	2015	The histidine functionalized perylenediimide (PDI-HIS) molecule could coassemble with amyloid beta (Abeta) peptides via hydrogen bonding that leads to the enhancement in the pi-pi interactions between Abeta and PDI-HIS moieties.	Histidine	4-13	peptidyl arginine deiminase 1	Homo sapiens	46-49
26340532-4	2015	The histidine functionalized perylenediimide (PDI-HIS) molecule could coassemble with amyloid beta (Abeta) peptides via hydrogen bonding that leads to the enhancement in the pi-pi interactions between Abeta and PDI-HIS moieties.	Histidine	4-13	peptidyl arginine deiminase 1	Homo sapiens	211-214
10551739-1	1999	The expression of Fhit (fragile histidine triad) protein in oral squamous cell carcinoma (OSCC) and adjacent oral epithelium was evaluated by immunohistochemistry on formalin-fixed paraffin-embedded blocks of 32 cases of OSCC.	Histidine	32-41	fragile histidine triad diadenosine triphosphatase	Homo sapiens	18-22
26340532-4	2015	The histidine functionalized perylenediimide (PDI-HIS) molecule could coassemble with amyloid beta (Abeta) peptides via hydrogen bonding that leads to the enhancement in the pi-pi interactions between Abeta and PDI-HIS moieties.	Histidine	50-53	peptidyl arginine deiminase 1	Homo sapiens	46-49
26340532-4	2015	The histidine functionalized perylenediimide (PDI-HIS) molecule could coassemble with amyloid beta (Abeta) peptides via hydrogen bonding that leads to the enhancement in the pi-pi interactions between Abeta and PDI-HIS moieties.	Histidine	50-53	peptidyl arginine deiminase 1	Homo sapiens	211-214
26340532-4	2015	The histidine functionalized perylenediimide (PDI-HIS) molecule could coassemble with amyloid beta (Abeta) peptides via hydrogen bonding that leads to the enhancement in the pi-pi interactions between Abeta and PDI-HIS moieties.	Histidine	215-218	peptidyl arginine deiminase 1	Homo sapiens	46-49
26340532-4	2015	The histidine functionalized perylenediimide (PDI-HIS) molecule could coassemble with amyloid beta (Abeta) peptides via hydrogen bonding that leads to the enhancement in the pi-pi interactions between Abeta and PDI-HIS moieties.	Histidine	215-218	peptidyl arginine deiminase 1	Homo sapiens	211-214
10669907-5	1999	In addition, when both antagonists were injected simultaneously, an additive effect was observed in antagonism of the L-histidine-induced increase in rCBF.	Histidine	118-129	CCAAT/enhancer binding protein zeta	Rattus norvegicus	150-154
26172912-0	2015	Distal Histidine Modulates the Unusual O-Binding of Nitrite to Myoglobin: Evidence from the Quantum Chemical Analysis of EPR Parameters.	Histidine	7-16	myoglobin	Homo sapiens	63-72
10669907-6	1999	L-Histidine caused no marked changes in blood pressure even at a dose of 1,500 mg/kg, which showed an increase in rCBF in the hippocampus.	Histidine	0-11	CCAAT/enhancer binding protein zeta	Rattus norvegicus	114-118
10525531-6	1999	Recombinant GST-Kap122p formed a complex with recombinant His(6)-Toa1p/Toa2p.	Histidine	58-61	transcription initiation factor IIA large subunit	Saccharomyces cerevisiae S288C	65-70
26035384-3	2015	The interaction with iron is likely to be important in the dimerisation of Abeta and is mediated by three N-terminal histidines.	Histidine	117-127	beta amyloid protein precursor-like	Drosophila melanogaster	75-80
10527871-4	1999	UCH-6 belonged to members of the UCH family containing highly conserved Cys, His, and Asp domains and showed 86% amino acid identity to human UCH-L3.	Histidine	77-80	ubiquitin C-terminal hydrolase L3	Gallus gallus	0-5
26132828-11	2015	Catalysis is based on a cysteine-histidine-asparagine triad, which is shared with human PAD1-PAD4 and other guanidino-group modifying enzymes.	Histidine	33-42	peptidyl arginine deiminase 1	Homo sapiens	88-92
26132828-11	2015	Catalysis is based on a cysteine-histidine-asparagine triad, which is shared with human PAD1-PAD4 and other guanidino-group modifying enzymes.	Histidine	33-42	peptidyl arginine deiminase 4	Homo sapiens	93-97
10502677-2	1999	To facilitate purification, an oligonucleotide consisting of 6 tandem codons for histidine and a stop codon was engineered into the TNSALP cDNA.	Histidine	81-90	alkaline phosphatase, biomineralization associated	Homo sapiens	132-138
25941362-4	2015	Based on the close proximity of the phosphate oxygen of A2662 of the SRL to the supposedly catalytic histidine of EF-G (His87), we probed this interaction by an atomic mutagenesis approach.	Histidine	101-110	G elongation factor mitochondrial 1	Homo sapiens	114-118
10550637-0	1999	Susceptibility of the guard-cell K(+)-uptake channel KST1 to Zn(2+) requires histidine residues in the S3-S4 linker and in the channel pore Potassium channels are inhibited by several mono- and divalent cations.	Histidine	77-86	Potassium channel KAT1-like	Solanum tuberosum	53-57
25886189-0	2015	Posttranslational modification and mutation of histidine 50 trigger alpha synuclein aggregation and toxicity.	Histidine	47-56	synuclein alpha	Homo sapiens	68-83
25574816-7	2015	RESULTS: Histone H1.2, which lacks histidine, was phosphorylated by phosphoramidate on several lysine residues, as shown by MS. PHPT1 was shown to dephosphorylate phosphohistone H1 at a rate similar to that previously described for the dephosphorylation of phosphohistidine-containing peptides.	Histidine	35-44	H1.2 linker histone, cluster member	Homo sapiens	17-21
10550637-6	1999	Since both histidines alter the susceptibility of KST1 to Zn(2+), the block may predominantly result from these two sites.	Histidine	11-21	Potassium channel KAT1-like	Solanum tuberosum	50-54
10455016-2	1999	Single amino acid mutations in human CYP17, Arg(347)--&gt;His and Arg(358)--&gt;Gln, have been reported to result in the loss of the lyase activity and to cause sexual phenotypic changes in 46XY male patients.	Histidine	58-61	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	37-42
24961462-6	2015	This article will therefore give an overview of our current knowledge on protein histidine phosphorylation in prokaryotes and lower eukaryotes and compare it with the regulatory phosphorylation and dephosphorylation of histidine residues in vertebrates by NDPK and PHP, respectively.	Histidine	81-90	cytidine/uridine monophosphate kinase 2	Homo sapiens	256-260
25608886-4	2015	In this study, we dissected the molecular mechanisms by which CCL2 neutralization inhibits HIV-1 replication in monocyte-derived macrophages (MDM), and the potential involvement of the innate restriction factors protein sterile alpha motif (SAM) histidine/aspartic acid (HD) domain containing 1 (SAMHD1) and apolipoprotein B mRNA-editing, enzyme-catalytic, polypeptide-like 3 (APOBEC3) family members.	Histidine	246-255	C-C motif chemokine ligand 2	Homo sapiens	62-66
10610126-5	1999	It was demonstrated for the first time that the receiver domain in this sensor exhibits a strong phosphohistidine phosphatase activity toward some Arabidopsis HPt phosphotransmitters (AHP1 and AHP2), suggesting the functional importance of the receiver domain for a resumed interaction of the sensor His-kinase with other His-Asp phosphorelay components.	Histidine	300-303	histidine-containing phosphotransmitter 1	Arabidopsis thaliana	184-188
25522875-4	2015	In this study, by incubating the Escherichia coli-derived His-tagged Oct4 proteins with the whole cell lysates of a variety of human cells followed by retrieving the reacted Oct4 proteins with the Ni-NTA beads, we developed a labor- and cost-effective in vitro PTM method that allowed for mass spectrometric determination of the phosphorylation profiles of Oct4 proteins exposed to various cell-free systems.	Histidine	58-61	POU class 5 homeobox 1	Homo sapiens	69-73
10411902-1	1999	Alteration of the FHIT (fragile histidine triad) gene occurs as an early and frequent event in lung carcinogenesis.	Histidine	32-41	fragile histidine triad diadenosine triphosphatase	Homo sapiens	18-22
25522875-4	2015	In this study, by incubating the Escherichia coli-derived His-tagged Oct4 proteins with the whole cell lysates of a variety of human cells followed by retrieving the reacted Oct4 proteins with the Ni-NTA beads, we developed a labor- and cost-effective in vitro PTM method that allowed for mass spectrometric determination of the phosphorylation profiles of Oct4 proteins exposed to various cell-free systems.	Histidine	58-61	POU class 5 homeobox 1	Homo sapiens	174-178
25522875-4	2015	In this study, by incubating the Escherichia coli-derived His-tagged Oct4 proteins with the whole cell lysates of a variety of human cells followed by retrieving the reacted Oct4 proteins with the Ni-NTA beads, we developed a labor- and cost-effective in vitro PTM method that allowed for mass spectrometric determination of the phosphorylation profiles of Oct4 proteins exposed to various cell-free systems.	Histidine	58-61	POU class 5 homeobox 1	Homo sapiens	174-178
10417619-4	1999	As the human Fc gamma receptor IIa proteins exist in two allotypes (one with a histidine at position 131, which binds immunoglobulin G1, 2, 3 and the other with an arginine at position 131, which binds immunoglobulin G1, and 3, but is unable to bind immunoglobulin G2), we expected an altered prevalence of histidine 131 forms in vasculitis patients.	Histidine	79-88	Fc gamma receptor IIa	Homo sapiens	13-34
25396429-4	2014	We demonstrate that binding of hemin to TCTP is mediated by a conserved His-containing motif (His76His77) followed by dimerization, an event that involves ligand-mediated conformational changes and that is necessary to trigger TCTP"s cytokine-like activity.	Histidine	72-75	tumor protein, translationally-controlled 1	Homo sapiens	40-44
25396429-4	2014	We demonstrate that binding of hemin to TCTP is mediated by a conserved His-containing motif (His76His77) followed by dimerization, an event that involves ligand-mediated conformational changes and that is necessary to trigger TCTP"s cytokine-like activity.	Histidine	72-75	tumor protein, translationally-controlled 1	Homo sapiens	227-231
10417619-4	1999	As the human Fc gamma receptor IIa proteins exist in two allotypes (one with a histidine at position 131, which binds immunoglobulin G1, 2, 3 and the other with an arginine at position 131, which binds immunoglobulin G1, and 3, but is unable to bind immunoglobulin G2), we expected an altered prevalence of histidine 131 forms in vasculitis patients.	Histidine	307-316	Fc gamma receptor IIa	Homo sapiens	13-34
25295538-2	2014	Here, through transcriptional profiling of genetically labeled cardiomyocytes, we identified expression of Purkinje cell protein-4 (Pcp4), a putative regulator of calmodulin and Ca2+/calmodulin-dependent kinase II (CaMKII) signaling, exclusively within the His-Purkinje network.	Histidine	257-260	Purkinje cell protein 4	Mus musculus	107-130
10364171-2	1999	Increases of external pH decrease the single-channel conductance in mutant R148H of the Kir2.1 channel (arginine is mutated into histidine) but not in the wild type channel.	Histidine	129-138	potassium inwardly rectifying channel subfamily J member 2	Homo sapiens	88-94
25295538-2	2014	Here, through transcriptional profiling of genetically labeled cardiomyocytes, we identified expression of Purkinje cell protein-4 (Pcp4), a putative regulator of calmodulin and Ca2+/calmodulin-dependent kinase II (CaMKII) signaling, exclusively within the His-Purkinje network.	Histidine	257-260	Purkinje cell protein 4	Mus musculus	132-136
10356324-2	1999	Recombinant Pus1, tagged with six histidine residues at its N terminus was expressed in Escherichia coli and purified.	Histidine	34-43	pseudouridine synthase PUS1	Saccharomyces cerevisiae S288C	12-16
25290245-7	2014	Previously, we reported that the His-rich domain of selenoprotein P (SelP-H) inhibited metal-induced aggregation and toxicity of Abeta, due to its metal chelation ability.	Histidine	33-36	selectin P	Homo sapiens	69-73
25290245-10	2014	This work implies that the surface-exposed His-rich domain of SelP makes it capable of modulating Cu(+)/Cu(2+)-mediated aggregation and neurotoxicity of both Ass and tau and may play important roles in the prevention of AD progression.	Histidine	43-46	selectin P	Homo sapiens	62-66
25160622-4	2014	AtCM1 is activated by tryptophan with phenylalanine and tyrosine acting as negative effectors; however, tryptophan, cysteine, and histidine activate AtCM3.	Histidine	130-139	chorismate mutase 1	Arabidopsis thaliana	0-5
10224104-5	1999	Mutation of Gln356 (Gln233 in E. coli MetAP) to alanine results in a catalytic efficiency about one-third that of native with normal substrates but which can cleave methionine from substrates with penultimate histidine, asparagine, glutamine, leucine, methionine, phenylalanine, and tryptophan.	Histidine	209-218	methionine aminopeptidase	Saccharomyces cerevisiae S288C	38-43
10222201-1	1999	The high-resolution X-ray structures have been determined for ten complexes formed between bovine beta-trypsin and P1 variants (Gly, Asp, Glu, Gln, Thr, Met, Lys, His, Phe, Trp) of bovine pancreatic trypsin inhibitor (BPTI).	Histidine	163-166	serine protease 1	Bos taurus	98-110
25049081-4	2014	Here, we constructed and characterized three catalytic triad mutants of TSP50 and found that all the mutants could significantly depress TSP50-induced cell proliferation and colony formation in vitro and tumor formation in vivo, and the aspartic acid at position 206 in the catalytic triad played a more crucial role than threonine and histidine in this process.	Histidine	336-345	serine protease 50	Homo sapiens	72-77
25049081-4	2014	Here, we constructed and characterized three catalytic triad mutants of TSP50 and found that all the mutants could significantly depress TSP50-induced cell proliferation and colony formation in vitro and tumor formation in vivo, and the aspartic acid at position 206 in the catalytic triad played a more crucial role than threonine and histidine in this process.	Histidine	336-345	serine protease 50	Homo sapiens	137-142
10226360-9	1999	During this study, the amino acid sequence originally derived from the DNA sequence of the gene coding for invertase was also verified and it was found that this protein when expressed from SUC2 gene might be created as more than one sequence which differ by a few amino acid substitutions (Asn58&lt;--&gt;Thr, Asn65--&gt;His and Val412&lt;--&gt;Ala).	Histidine	322-325	beta-fructofuranosidase SUC2	Saccharomyces cerevisiae S288C	190-194
25229620-6	2014	In the present study, we expressed and purified recombinant human endostatin (rhEndostatin) that contained 3 additional amino acid residues (arginine, glycine, and serine) at the amino-terminus and 6 histidine residues in its carboxyl terminus.	Histidine	200-209	collagen type XVIII alpha 1 chain	Homo sapiens	66-76
10082561-10	1999	The addition of bacterially expressed, purified His-C/EBPalpha to the E2F binding reaction resulted in the disruption of E2F complexes containing p107 in nuclear extracts from C/EBPalpha knockout mouse livers.	Histidine	48-51	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	52-62
25330531-0	2014	Hemoglobin Lansing (Alpha) [HBA2 CD87 (HIS&gt;GLU) (C&gt;A)] in a Turkish Individual Resulting from Another Nucleotide Substitution.	Histidine	39-42	plasminogen activator, urokinase receptor	Homo sapiens	33-37
10082561-10	1999	The addition of bacterially expressed, purified His-C/EBPalpha to the E2F binding reaction resulted in the disruption of E2F complexes containing p107 in nuclear extracts from C/EBPalpha knockout mouse livers.	Histidine	48-51	RB transcriptional corepressor like 1	Mus musculus	146-150
10082561-10	1999	The addition of bacterially expressed, purified His-C/EBPalpha to the E2F binding reaction resulted in the disruption of E2F complexes containing p107 in nuclear extracts from C/EBPalpha knockout mouse livers.	Histidine	48-51	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	176-186
25100325-0	2014	The C113D mutation in human Pin1 causes allosteric structural changes in the phosphate binding pocket of the PPIase domain through the tug of war in the dual-histidine motif.	Histidine	158-167	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	28-32
10090754-5	1999	The active site of Fhit contains a histidine motif that is reminiscent of the HPH motif in galactose-1-phosphate uridylyltransferases, in which the first histidine residue serves as the nucleophilic catalyst to which the nucleotidyl group is bonded covalently in the covalent intermediate.	Histidine	35-44	fragile histidine triad diadenosine triphosphatase	Homo sapiens	19-23
25027712-2	2014	Here we report structural results illuminating how LIMP-2 binds and releases beta-GCase according to changes in pH, via a histidine trigger, and suggesting that LIMP-2 localizes the ceramide portion of the substrate adjacent to the beta-GCase catalytic site.	Histidine	122-131	scavenger receptor class B member 2	Homo sapiens	51-57
25027712-2	2014	Here we report structural results illuminating how LIMP-2 binds and releases beta-GCase according to changes in pH, via a histidine trigger, and suggesting that LIMP-2 localizes the ceramide portion of the substrate adjacent to the beta-GCase catalytic site.	Histidine	122-131	glucosylceramidase beta	Homo sapiens	77-87
10090754-5	1999	The active site of Fhit contains a histidine motif that is reminiscent of the HPH motif in galactose-1-phosphate uridylyltransferases, in which the first histidine residue serves as the nucleophilic catalyst to which the nucleotidyl group is bonded covalently in the covalent intermediate.	Histidine	154-163	fragile histidine triad diadenosine triphosphatase	Homo sapiens	19-23
10102990-5	1999	The essential three amino acids in the active site triad, His, Asp, and Ser, and the single putative N-glycosylation site were conserved in human and mouse neuropsin.	Histidine	58-61	opsin 5	Mus musculus	156-165
24840168-4	2014	Structural and experimental studies are still unable to resolve the mechanistic role and protonation states of two adjacent histidines (His59 and His157) and a cysteine (Cys113) in the active site of Pin1.	Histidine	124-134	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	200-204
24840168-5	2014	Here, we show that the protonation state of Cys113 mediates a dynamic hydrogen-bonding network in the active site of Pin1, involving the two adjacent histidines and several other residues that are highly conserved and necessary for catalysis.	Histidine	150-160	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	117-121
24840168-6	2014	We have used detailed free energy calculations and molecular dynamics simulations, complementing previous experiments, to resolve the ambiguities in the orientations of the histidines and protonation states of these key active site residues, details that are critical for fully understanding the mechanism of Pin1 and necessary for developing potent inhibitors.	Histidine	173-183	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	309-313
24829455-2	2014	However, recent analysis of an Exo1-E109K knockin mouse has concluded that Exo1 function in mammalian mismatch repair is restricted to a structural role, a conclusion based on a prior report that N-terminal His-tagged Exo1-E109K is hydrolytically defective.	Histidine	207-210	exonuclease 1	Homo sapiens	75-79
11776848-1	1999	OBJECTIVE: To investigate alterations of fragile histidine triad (FHIT) gene and p16 gene in lung cancer.	Histidine	49-58	fragile histidine triad diadenosine triphosphatase	Homo sapiens	66-70
24736394-5	2014	We further mapped the interaction regions to the 1-9 armadillo repeats of beta-catenin and the BTB domain of KCTD1, especially Position Ala-30 and His-33.	Histidine	147-150	catenin beta 1	Homo sapiens	74-86
10024455-5	1999	The active site of PTPS consists of the pterin-anchoring Glu A107 neighboured by two catalytic motifs: a Zn(II) binding site and an intersubunit catalytic triad formed by Cys A42, Asp B88 and His B89.	Histidine	192-195	6-pyruvoyltetrahydropterin synthase	Homo sapiens	19-23
24291446-2	2014	We used auto-induction for histidine-tagged BZLF1 expression in Escherichia coli and immobilized cobalt affinity membrane chromatography for protein purification under native conditions.	Histidine	27-36	protein Zta	Human gammaherpesvirus 4	44-49
10027335-1	1999	To investigate involvement of an aberrant expression of the FHIT (fragile histidine triad) gene in the process of carcinogenesis and progression in cervical carcinoma, we examined its expression by the reverse transcriptase polymerase chain reaction (RT-PCR) and cDNA sequence method in 32 cervical invasive carcinomas (25 squamous cell carcinomas and seven adeno- or adenosquamous carcinomas) and 18 of its precursor lesions [four low-grade and 14 high-grade cervical intraepithelial neoplasias (CINs)].	Histidine	74-83	fragile histidine triad diadenosine triphosphatase	Homo sapiens	60-64
24140707-2	2014	A single histidine residue in eEF2 (H715) is modified to form diphthamide.	Histidine	9-18	eukaryotic translation elongation factor 2	Homo sapiens	30-34
24282278-7	2014	Recombinant MDA-7/IL-24 (His-MDA-7) induces SARI expression, supporting the involvement of SARI in the MDA-7/IL-24-driven autocrine loop, culminating in antitumor effects.	Histidine	25-28	interleukin 24	Homo sapiens	12-17
24282278-7	2014	Recombinant MDA-7/IL-24 (His-MDA-7) induces SARI expression, supporting the involvement of SARI in the MDA-7/IL-24-driven autocrine loop, culminating in antitumor effects.	Histidine	25-28	interleukin 24	Homo sapiens	18-23
24282278-7	2014	Recombinant MDA-7/IL-24 (His-MDA-7) induces SARI expression, supporting the involvement of SARI in the MDA-7/IL-24-driven autocrine loop, culminating in antitumor effects.	Histidine	25-28	interleukin 24	Homo sapiens	29-34
24282278-7	2014	Recombinant MDA-7/IL-24 (His-MDA-7) induces SARI expression, supporting the involvement of SARI in the MDA-7/IL-24-driven autocrine loop, culminating in antitumor effects.	Histidine	25-28	interleukin 24	Homo sapiens	29-34
24282278-7	2014	Recombinant MDA-7/IL-24 (His-MDA-7) induces SARI expression, supporting the involvement of SARI in the MDA-7/IL-24-driven autocrine loop, culminating in antitumor effects.	Histidine	25-28	interleukin 24	Homo sapiens	109-114
10051705-2	1999	Histamine is synthesized by L-histidine, catalysed by L-histidine decarboxylase (HDC) and metabolized mainly by histamine N-methyltransferase (HMT).	Histidine	28-39	histidine decarboxylase	Homo sapiens	54-79
24282278-8	2014	Moreover, His-MDA-7, after binding to its cognate receptors (IL-20R1/IL-20R2 or IL-22R/IL-20R2), induces intracellular signaling by phosphorylation of p38 MAPK, leading to transcription of a family of growth arrest and DNA damage inducible (GADD) genes, culminating in apoptosis.	Histidine	10-13	interleukin 24	Homo sapiens	14-19
2611263-8	1989	These results indicate that the two Zn2+ ions in TFIIIA are coordinated with the cysteine and histidine residues and are required for maintenance of the proper conformation of TFIIIA.	Histidine	94-103	general transcription factor 3A L homeolog	Xenopus laevis	49-55
2611263-8	1989	These results indicate that the two Zn2+ ions in TFIIIA are coordinated with the cysteine and histidine residues and are required for maintenance of the proper conformation of TFIIIA.	Histidine	94-103	general transcription factor 3A L homeolog	Xenopus laevis	176-182
2691018-5	1989	A point mutation at this location corresponds to a substitution of histidine for glutamine in the N-ras gene product, p21.	Histidine	67-76	H3 histone pseudogene 16	Homo sapiens	118-121
24635366-9	2014	RESULTS: Thirteen potentially functional IL-11 gene variants, the G to A transversions at the position 3651 (G3651A) leading to the arginin to histidin exchange on the position 113 (R113H) were detected in the group of infertile women.	Histidine	143-151	interleukin 11	Homo sapiens	41-46
10051705-2	1999	Histamine is synthesized by L-histidine, catalysed by L-histidine decarboxylase (HDC) and metabolized mainly by histamine N-methyltransferase (HMT).	Histidine	28-39	histidine decarboxylase	Homo sapiens	81-84
23666425-8	2013	This NO acts on the RGSZ2 zinc finger, providing the zinc ions that are required for PKC/Raf-1 cysteine-rich domains to simultaneously bind to the histidines present in the HINT1 homodimer.	Histidine	147-157	protein kinase C gamma	Homo sapiens	85-88
9839518-4	1998	METHODS: The amino-terminus of hEDN was extended by four amino acid residues, corresponding to the proximal part of the hEDN signal peptide (serine, leucine, histidine, and valine; positions -4 to -1, respectively), by use of the polymerase chain reaction and an hEDN complementary DNA.	Histidine	158-167	ribonuclease A family member 2	Homo sapiens	31-35
24100012-3	2013	Combining the yeast two-hybrid system with genetic analysis, we show here that the cysteine- and histidine-rich (CH) domain and the RNA helicase domain of yeast Upf1 can engage in two new types of molecular interactions: an intramolecular interaction between these two domains and self-association of each of these domains.	Histidine	97-106	ATP-dependent RNA helicase NAM7	Saccharomyces cerevisiae S288C	161-165
2526198-1	1989	A hypothesis was examined that carboxypeptidase H (CpAse H), which is known to catalyse the release of lysine and arginine from the C-terminus of peptides, can also release histidine, tyrosine, and phenylalanine.	Histidine	173-182	carboxypeptidase E	Homo sapiens	31-49
2526198-1	1989	A hypothesis was examined that carboxypeptidase H (CpAse H), which is known to catalyse the release of lysine and arginine from the C-terminus of peptides, can also release histidine, tyrosine, and phenylalanine.	Histidine	173-182	carboxypeptidase E	Homo sapiens	51-58
2793310-7	1989	However, derivative II presents some differences as it was found an enhancement of the pK2 values of both His-12 and His-119.	Histidine	106-109	prokineticin 2	Bos taurus	87-90
2793310-7	1989	However, derivative II presents some differences as it was found an enhancement of the pK2 values of both His-12 and His-119.	Histidine	117-120	prokineticin 2	Bos taurus	87-90
9839518-4	1998	METHODS: The amino-terminus of hEDN was extended by four amino acid residues, corresponding to the proximal part of the hEDN signal peptide (serine, leucine, histidine, and valine; positions -4 to -1, respectively), by use of the polymerase chain reaction and an hEDN complementary DNA.	Histidine	158-167	ribonuclease A family member 2	Homo sapiens	120-124
2793310-8	1989	Interaction of derivative II and derivative E with dApdA increases the pK2 of His-119, whereas a decrease is found when it interacts with ribonuclease A.	Histidine	78-81	prokineticin 2	Bos taurus	71-74
24082096-4	2013	Functional studies on channel mutants and structural investigations on recombinant inactivation ball domain peptides encompassing the first 61 residues of Kv1.4 revealed a heme-responsive binding motif involving Cys13:His16 and a secondary histidine at position 35.	Histidine	240-249	potassium voltage-gated channel subfamily A member 4	Homo sapiens	155-160
9839518-4	1998	METHODS: The amino-terminus of hEDN was extended by four amino acid residues, corresponding to the proximal part of the hEDN signal peptide (serine, leucine, histidine, and valine; positions -4 to -1, respectively), by use of the polymerase chain reaction and an hEDN complementary DNA.	Histidine	158-167	ribonuclease A family member 2	Homo sapiens	120-124
9813077-1	1998	L-Histidine decarboxylase (HDC) catalyzes the formation of histamine from L-histidine, and in hematopoietic cell lineages the gene is expressed only in mast cells and basophils.	Histidine	74-85	histidine decarboxylase	Homo sapiens	0-25
24137022-8	2013	Also the pathophysiological relevance of serum carnosinase, the enzyme actively degrading carnosine into l-histidine and beta-alanine, is discussed.	Histidine	105-116	carnosine dipeptidase 1	Homo sapiens	41-58
2567165-4	1989	The tyrosinase gene in the Himalayan mouse contains an A----G change at nucleotide 1259 that alters a histidine residue to an arginine residue at amino acid 420.	Histidine	102-111	tyrosinase	Mus musculus	4-14
2707256-0	1989	The histidine residue of codon 715 is essential for function of elongation factor 2.	Histidine	4-13	eukaryotic translation elongation factor 2	Mus musculus	64-83
9813077-1	1998	L-Histidine decarboxylase (HDC) catalyzes the formation of histamine from L-histidine, and in hematopoietic cell lineages the gene is expressed only in mast cells and basophils.	Histidine	74-85	histidine decarboxylase	Homo sapiens	27-30
24001608-6	2013	Analyses of oastlABC pollen demonstrated that the presence of at least one functional OAS-TL isoform is essential for the proper function of the male gametophyte, although the synthesis of histidine, lysine, and tryptophan is dispensable in pollen.	Histidine	189-198	O-acetylserine (thiol) lyase (OAS-TL) 	Arabidopsis thaliana	86-92
9794789-0	1998	Roles of the N- and C-terminal domains of carnitine palmitoyltransferase I isoforms in malonyl-CoA sensitivity of the enzymes: insights from expression of chimaeric proteins and mutation of conserved histidine residues.	Histidine	200-209	carnitine palmitoyltransferase 1B	Rattus norvegicus	42-74
23873822-8	2013	Amino acid residues of histidine at position 171 and phenylalanine at position 67, both of which are located in antigen binding grooves of the HLA-B protein, were associated with TAK susceptibility (P &lt;= 3.8 x 10(-5)) with a significant difference from other amino acid variations (DeltaAIC &gt;= 9.65).	Histidine	23-32	major histocompatibility complex, class I, B	Homo sapiens	143-148
2707256-2	1989	Amino acid substitution for the histidine residue of codon 715, which is modified post-translationally to diphthamide, resulted in non-functional EF-2 and this substitution did not render EF-2 resistant to Pseudomonas aeruginosa exotoxin A, which inactivates EF-2 transferring ADP-ribose to the diphthamide residue.	Histidine	32-41	eukaryotic translation elongation factor 2	Mus musculus	146-150
9794789-8	1998	Additionally, further weight is added to the notion that one or more histidine residues may be involved in the CPT I-malonyl-CoA interaction.	Histidine	69-78	carnitine palmitoyltransferase 1B	Rattus norvegicus	111-116
2725819-6	1989	Results indicate that normal human CSF does not contain ChAT and all ACh-SA in CSF reflects non-enzymatic imidazole/histidine-like catalyzed synthesis.	Histidine	116-125	colony stimulating factor 2	Homo sapiens	35-38
2725819-6	1989	Results indicate that normal human CSF does not contain ChAT and all ACh-SA in CSF reflects non-enzymatic imidazole/histidine-like catalyzed synthesis.	Histidine	116-125	colony stimulating factor 2	Homo sapiens	79-82
23863217-3	2013	The VCS spectra revealed for the first time several low-frequency heme modes that are sensitive to cyt c unfolding: gamma(a) (~50 cm(-1)), gamma(b) (~80 cm(-1)), gamma(c) (~100 cm(-1)), and nu(s)(His-Fe-His) at 205 cm(-1).	Histidine	196-199	cytochrome c, somatic	Equus caballus	99-104
23863217-3	2013	The VCS spectra revealed for the first time several low-frequency heme modes that are sensitive to cyt c unfolding: gamma(a) (~50 cm(-1)), gamma(b) (~80 cm(-1)), gamma(c) (~100 cm(-1)), and nu(s)(His-Fe-His) at 205 cm(-1).	Histidine	203-206	cytochrome c, somatic	Equus caballus	99-104
9753439-8	1998	Both the mono- and pentaglutamate derivatives of 5-CHO-H4PteGlun were cross-linked to SHMT by a carbodiimide reaction to Lys-450 which resides in a stretch of Lys, His, and Arg residues.	Histidine	164-167	serine hydroxymethyltransferase, cytosolic	Oryctolagus cuniculus	86-90
2713873-6	1989	The resonance of the H-2 atom of the histidine, considered to be the N-terminal residue and to be located in the heparin binding-site, is strongly perturbed by heparin binding both to native and modified antithrombin.	Histidine	37-46	serpin family C member 1	Homo sapiens	204-216
24058416-7	2013	A structural comparison of the RING2 domain with the HECT E3 ligase NEDD4 reveals a near mirror image of the cysteine and histidine residues in the catalytic site.	Histidine	122-131	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	68-73
2713873-8	1989	Resonances from two of the remaining four histidine units are sensitive to longer-range conformational changes, and show differences between binding of the two heparin species both in native and modified ATIII.	Histidine	42-51	serpin family C member 1	Homo sapiens	204-209
9724051-4	1998	Histamine is formed from L-histidine by histidine decarboxylase (HDC).	Histidine	25-36	histidine decarboxylase	Mus musculus	40-63
2901989-0	1988	Effect of site-specific mutagenesis of tyrosine-55, methionine-110 and histidine-217 in porcine kidney D-amino acid oxidase on its catalytic function.	Histidine	71-80	D-amino acid oxidase	Homo sapiens	103-123
2901989-1	1988	To assess the contributions of Tyr-55, Met-110 and His-217 in porcine kidney D-amino acid oxidase (EC 1.4.3.3, DAO) to its catalytic function, we constructed three mutant cDNAs coding for the enzymes possessing Phe-55, Leu-110 and Leu-217 by site-specific mutagenesis.	Histidine	51-54	D-amino acid oxidase	Homo sapiens	77-97
23474485-6	2013	Inhibition of HGP by histidine was also blocked by ICV administration of a histamine H1 receptor antagonist.	Histidine	21-30	histamine receptor H1	Mus musculus	75-96
23652332-5	2013	Here, we reported that the His-rich domain of selenoprotein P (SelP-H) and the Sec-to-Cys mutant selenoprotein M (SelM") are capable of binding transition metal ions and modulating the Zn(2+)-mediated Abeta aggregation, ROS production and neurotoxicity.	Histidine	27-30	selectin P	Homo sapiens	63-67
9724051-4	1998	Histamine is formed from L-histidine by histidine decarboxylase (HDC).	Histidine	25-36	histidine decarboxylase	Mus musculus	65-68
9718294-5	1998	The mutant with the fewest residues deleted, apo Delta(88-98)A-I(+his), has the least secondary structure (only 34% helix) and is also the least stable (DeltaG = 2.9 kcal/mol).	Histidine	66-69	serine peptidase inhibitor, Kunitz type 1	Homo sapiens	61-64
23678519-20	2004	A cyclic heptapeptide, cyclo(Cys-Asn-Asn-Ser-Lys-Ser-His-Thr-Cys) (R832), was identified with phage screening against VCAM-1 (12).	Histidine	53-56	vascular cell adhesion molecule 1	Mus musculus	118-124
3180829-1	1988	Bovine lens calf gamma-II crystallin contains five histidine residues at sequence positions 14, 53, 84, 117, and 122.	Histidine	51-60	G protein subunit gamma 7	Bos taurus	17-25
26105914-8	2013	Furthermore we could show a fourfold reduction to encounter severe course of preeclampsia (defined as occurrence of HELLP-syndrome or eclampsia) in carriers of the EPHX1 polymorphism encoding histidine.	Histidine	192-201	epoxide hydrolase 1	Homo sapiens	164-169
9718294-7	1998	Apo Delta(1-65)A-I(+his) exhibited a discrete species which was less asymmetric (dimensions equal to 9 x 2.9 nm).	Histidine	20-23	serine peptidase inhibitor, Kunitz type 1	Homo sapiens	15-18
9718294-11	1998	Apo Delta(1-43)A-I, apo Delta(1-65)A-I(+his), and apo Delta(88-98)A-I(+his) show lipid affinities statistically similar to apo wtA-I(+his), but significantly defective DMPC clearance kinetics.	Histidine	40-43	serine peptidase inhibitor, Kunitz type 1	Homo sapiens	35-38
3292705-11	1988	It is concluded that LHRH degradation is primarily initiated by the membrane-bound form of endopeptidase-24.15 to yield pGlu-His-Trp-Ser-Tyr and to a lesser extent by endopeptidase-24.11 to yield pGlu-His-Trp-Ser-Tyr-Gly.	Histidine	125-128	gonadotropin releasing hormone 1	Mus musculus	21-25
3292705-11	1988	It is concluded that LHRH degradation is primarily initiated by the membrane-bound form of endopeptidase-24.15 to yield pGlu-His-Trp-Ser-Tyr and to a lesser extent by endopeptidase-24.11 to yield pGlu-His-Trp-Ser-Tyr-Gly.	Histidine	201-204	gonadotropin releasing hormone 1	Mus musculus	21-25
23212911-0	2013	The pH sensitivity of murine heat shock protein 47 (HSP47) binding to collagen is affected by mutations in the breach histidine cluster.	Histidine	118-127	serine (or cysteine) peptidase inhibitor, clade H, member 1	Mus musculus	29-50
9718294-11	1998	Apo Delta(1-43)A-I, apo Delta(1-65)A-I(+his), and apo Delta(88-98)A-I(+his) show lipid affinities statistically similar to apo wtA-I(+his), but significantly defective DMPC clearance kinetics.	Histidine	40-43	serine peptidase inhibitor, Kunitz type 1	Homo sapiens	35-38
23212911-0	2013	The pH sensitivity of murine heat shock protein 47 (HSP47) binding to collagen is affected by mutations in the breach histidine cluster.	Histidine	118-127	serine (or cysteine) peptidase inhibitor, clade H, member 1	Mus musculus	52-57
23212911-3	2013	HSP47 binds procollagen at a neutral pH but releases at a pH similar to the pK(a) of the imidazole side chain of histidine residues.	Histidine	113-122	serine (or cysteine) peptidase inhibitor, clade H, member 1	Mus musculus	0-5
9718294-14	1998	Importantly, studies on apo Delta(88-98)A-I(+his) provide the first experimental evidence that a native-like structure is not necessary for native-like lipid affinity, but apparently is necessary for both DMPC solubilization and LCAT activation.	Histidine	45-48	serine peptidase inhibitor, Kunitz type 1	Homo sapiens	40-43
23212911-5	2013	Murine HSP47 has 14 histidine residues grouped into three clusters, known as the breach, gate, and shutter.	Histidine	20-29	serine (or cysteine) peptidase inhibitor, clade H, member 1	Mus musculus	7-12
23212911-6	2013	Here, we report the use of histidine mutagenesis to demonstrate the relative contribution of these three clusters to HSP47 structure and the "pH switch."	Histidine	27-36	serine (or cysteine) peptidase inhibitor, clade H, member 1	Mus musculus	117-122
23212911-9	2013	Thus, His-198, His-197 and His-191 are important (if not central) to HSP47 mechanism of binding/release to collagen.	Histidine	6-9	serine (or cysteine) peptidase inhibitor, clade H, member 1	Mus musculus	69-74
9685724-6	1998	Amino acid substitutions at a signal peptide-cleavage site, His-Ser-Leu4 to Pro-Met-Va14, in the mature Mn-SOD prevented the processing of the precursor protein, and thus resulted in the accumulation of the precursor protein within mitochondria, as judged on immunostaining with an anti-Mn-SOD antibody.	Histidine	60-63	superoxide dismutase 2	Homo sapiens	104-110
23212911-9	2013	Thus, His-198, His-197 and His-191 are important (if not central) to HSP47 mechanism of binding/release to collagen.	Histidine	15-18	serine (or cysteine) peptidase inhibitor, clade H, member 1	Mus musculus	69-74
23212911-9	2013	Thus, His-198, His-197 and His-191 are important (if not central) to HSP47 mechanism of binding/release to collagen.	Histidine	15-18	serine (or cysteine) peptidase inhibitor, clade H, member 1	Mus musculus	69-74
3131338-4	1988	Diethyl pyrocarbonate measurements indicate that the old enzyme has 1 histidine residue less than the young enzyme.	Histidine	70-79	hyaluronan synthase 1	Rattus norvegicus	64-69
9685724-6	1998	Amino acid substitutions at a signal peptide-cleavage site, His-Ser-Leu4 to Pro-Met-Va14, in the mature Mn-SOD prevented the processing of the precursor protein, and thus resulted in the accumulation of the precursor protein within mitochondria, as judged on immunostaining with an anti-Mn-SOD antibody.	Histidine	60-63	superoxide dismutase 2	Homo sapiens	287-293
2835106-2	1988	The ability of cytochrome b5 to support methoxyfluorane oxidation is affected by treatment with diethylpyrocarbonate, a reagent that at neutral pH is relatively specific for histidine residues.	Histidine	174-183	cytochrome b5 type A	Homo sapiens	15-28
22967951-6	2013	MsrA adsorbs on the hydrophobic carbon electrode surface preferentially through the three hydrophobic domains, C1, C2 and C3, which contain the tyrosine, tryptophan and histidine residues, and tryptophan exists only in these regions, and undergo electrochemical oxidation.	Histidine	169-178	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	111-124
9671501-2	1998	We purified a polyhistidine-tagged form of Prt1p (His-Prt1p) by Ni2+ affinity and gel filtration chromatography and obtained a complex of approximately 600 kDa composed of six polypeptides whose copurification was completely dependent on the polyhistidine tag on His-Prt1p.	Histidine	50-53	translation initiation factor eIF3 core subunit b	Saccharomyces cerevisiae S288C	43-48
2835106-4	1988	The studies reported in this paper were undertaken to determine whether histidine modification was involved in the decrease in effectiveness of cytochrome b5, or whether the inactivation could be attributed to modification of another amino acid.	Histidine	72-81	cytochrome b5 type A	Homo sapiens	144-157
2835106-5	1988	Our experiments demonstrate that diethylpyrocarbonate inactivates detergent-solubilized cytochrome b5 by modifying the axial histidines and displacing the heme.	Histidine	125-135	cytochrome b5 type A	Homo sapiens	88-101
9671501-2	1998	We purified a polyhistidine-tagged form of Prt1p (His-Prt1p) by Ni2+ affinity and gel filtration chromatography and obtained a complex of approximately 600 kDa composed of six polypeptides whose copurification was completely dependent on the polyhistidine tag on His-Prt1p.	Histidine	50-53	translation initiation factor eIF3 core subunit b	Saccharomyces cerevisiae S288C	54-59
9671501-2	1998	We purified a polyhistidine-tagged form of Prt1p (His-Prt1p) by Ni2+ affinity and gel filtration chromatography and obtained a complex of approximately 600 kDa composed of six polypeptides whose copurification was completely dependent on the polyhistidine tag on His-Prt1p.	Histidine	50-53	translation initiation factor eIF3 core subunit b	Saccharomyces cerevisiae S288C	54-59
23154171-5	2013	NMR pH titration of histidine residues of beta2m has also indicated that His84 has an abnormally low pK(a) value in the native state.	Histidine	20-29	beta-2-microglobulin	Homo sapiens	42-48
9632755-4	1998	Affinity isolation of histidine-tagged Sba1p (Sba1(His6)) after expression in yeast led to coisolation of Hsp90 and the cyclophilin homolog Cpr6.	Histidine	22-31	Hsp90 cochaperone SBA1	Saccharomyces cerevisiae S288C	39-44
2450576-7	1988	By magnetization transfer experiments with selectively deuteriated Fab fragment of the antibody, we have found that in TE32 and TE33 the histidine residue of the peptide is buried in a hydrophobic pocket of the antibody combining site, formed by a tryptophan and two tyrosine residues.	Histidine	137-146	FA complementation group B	Homo sapiens	67-70
9632755-4	1998	Affinity isolation of histidine-tagged Sba1p (Sba1(His6)) after expression in yeast led to coisolation of Hsp90 and the cyclophilin homolog Cpr6.	Histidine	22-31	Hsp90 cochaperone SBA1	Saccharomyces cerevisiae S288C	39-43
23172351-2	2012	We recently reported that NIa efficiently cleaved the amyloid-beta (Abeta) peptide, which contains the sequence Val-His-His-Gln in the vicinity of the cleavage site by alpha-secretase, and that the expression of NIa using a lentiviral system in the brain of AD mouse model reduced plaque deposition levels.	Histidine	116-119	amyloid beta (A4) precursor protein	Mus musculus	68-73
23172351-2	2012	We recently reported that NIa efficiently cleaved the amyloid-beta (Abeta) peptide, which contains the sequence Val-His-His-Gln in the vicinity of the cleavage site by alpha-secretase, and that the expression of NIa using a lentiviral system in the brain of AD mouse model reduced plaque deposition levels.	Histidine	120-123	amyloid beta (A4) precursor protein	Mus musculus	68-73
3197399-4	1988	Three histidyl residues/subunit were modified by DEP (0.2 mM, pH 6.8), but activity was completely lost after the first one had reacted, indicating the presence of one histidine residue essential for ALA-D catalysis.	Histidine	168-177	aminolevulinate dehydratase	Sus scrofa	200-205
9632755-4	1998	Affinity isolation of histidine-tagged Sba1p (Sba1(His6)) after expression in yeast led to coisolation of Hsp90 and the cyclophilin homolog Cpr6.	Histidine	22-31	1-(5-phosphoribosyl)-5- ((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase HIS6	Saccharomyces cerevisiae S288C	51-55
9632755-4	1998	Affinity isolation of histidine-tagged Sba1p (Sba1(His6)) after expression in yeast led to coisolation of Hsp90 and the cyclophilin homolog Cpr6.	Histidine	22-31	peptidylprolyl isomerase CPR6	Saccharomyces cerevisiae S288C	140-144
23105118-0	2012	The M2 module of the Cys-His-rich domain (CHRD) of PCSK9 protein is needed for the extracellular low-density lipoprotein receptor (LDLR) degradation pathway.	Histidine	25-28	proprotein convertase subtilisin/kexin type 9	Homo sapiens	51-56
9576908-3	1998	Fhit protein is a diadenosine P1,P3-triphosphate (ApppA) hydrolase whose fungal and animal homologs form a branch of the histidine triad (HIT) superfamily of nucleotide-binding proteins.	Histidine	121-130	fragile histidine triad diadenosine triphosphatase	Homo sapiens	0-4
23105118-0	2012	The M2 module of the Cys-His-rich domain (CHRD) of PCSK9 protein is needed for the extracellular low-density lipoprotein receptor (LDLR) degradation pathway.	Histidine	25-28	low density lipoprotein receptor	Homo sapiens	97-129
23105118-0	2012	The M2 module of the Cys-His-rich domain (CHRD) of PCSK9 protein is needed for the extracellular low-density lipoprotein receptor (LDLR) degradation pathway.	Histidine	25-28	low density lipoprotein receptor	Homo sapiens	131-135
22945239-1	2012	Human mitochondrial protein mitoNEET is a novel target of type II diabetes drug pioglitazone, and contains a redox active [2Fe-2S] cluster that is hosted by a unique ligand arrangement of three cysteine and one histidine residues.	Histidine	211-220	CDGSH iron sulfur domain 1	Homo sapiens	28-36
3663595-5	1987	258, 14048-14053] at low denaturant concentration was detected here by discontinuous changes in the chemical shifts of the C(2) protons of two of the five histidines in human antithrombin III and of three of the six histidines in bovine antithrombin III.	Histidine	155-165	serpin family C member 1	Homo sapiens	175-191
3663595-5	1987	258, 14048-14053] at low denaturant concentration was detected here by discontinuous changes in the chemical shifts of the C(2) protons of two of the five histidines in human antithrombin III and of three of the six histidines in bovine antithrombin III.	Histidine	155-165	serpin family C member 1	Homo sapiens	237-253
3663595-5	1987	258, 14048-14053] at low denaturant concentration was detected here by discontinuous changes in the chemical shifts of the C(2) protons of two of the five histidines in human antithrombin III and of three of the six histidines in bovine antithrombin III.	Histidine	216-226	serpin family C member 1	Homo sapiens	175-191
3663595-5	1987	258, 14048-14053] at low denaturant concentration was detected here by discontinuous changes in the chemical shifts of the C(2) protons of two of the five histidines in human antithrombin III and of three of the six histidines in bovine antithrombin III.	Histidine	216-226	serpin family C member 1	Homo sapiens	237-253
9576908-7	1998	The form of Fhit bound to two ApppA substrates would present to the cell a dramatically phosphorylated surface, prominently displaying six phosphate groups and two adenosine moieties in place of a deep cavity lined with histidines, arginines, and glutamines.	Histidine	220-230	fragile histidine triad diadenosine triphosphatase	Homo sapiens	12-16
3663595-6	1987	These two histidines in human antithrombin III are assigned to residue 1 and, more tentatively, to residue 65.	Histidine	10-20	serpin family C member 1	Homo sapiens	30-46
3663595-10	1987	From the tentative assignment of one of these resonances to histidine-1, it is proposed that the heparin binding site of antithrombin III is located in the N-terminal region and that this region forms a separate domain from the rest of the protein.	Histidine	60-69	serpin family C member 1	Homo sapiens	121-137
9600253-8	1998	The invariant PrP residues Tyr-128 and His-177 align with the two presumed active-site residues of signal peptidases and are in close spatial proximity in the three-dimensional structure of PrP(121-231).	Histidine	39-42	prion protein	Mus musculus	190-193
3663595-12	1987	Thermal denaturation also leads to major perturbation of these two histidine resonances in human antithrombin III, though stable intermediates in the unfolding were not detected.	Histidine	67-76	serpin family C member 1	Homo sapiens	97-113
23078533-0	2012	Evidence for a dual functional role of a conserved histidine in RNA DNA heteroduplex cleavage by human RNase H1.	Histidine	51-60	ribonuclease H1	Homo sapiens	103-111
3106550-6	1987	BALB/c apoA-II contains one residue each of histidine and arginine, neither of which are found in the human A-II protein.	Histidine	44-53	apolipoprotein A2	Homo sapiens	7-14
9537583-2	1998	Recent studies have localized the FHIT (fragile histidine triad) gene in this region and also demonstrated a high frequency of abnormalities of this gene in various cancers.	Histidine	48-57	fragile histidine triad diadenosine triphosphatase	Homo sapiens	34-38
3792312-1	1986	Starvation of the mouse hepatoma cell line Hepa for an essential amino acid (Trp, His, Leu, Ile or Phe) stimulated the incorporation of [3H]adenosine as ADP-ribose monomer into an 80,000-Mr protein, P80.	Histidine	82-85	coilin	Mus musculus	199-202
22932941-3	2012	The non-TFPI expressing cell line CHO-K1 was stably transfected with pcDNA3.1/V5-His-TOPO-TFPI and control cells were established by transfecting the CHO-K1 cells with pcDNA3.1/V5-His-TOPO.	Histidine	81-84	tissue factor pathway inhibitor	Cricetulus griseus	90-94
23166962-20	2004	Cy5.5-8-Amino-octanoic acid-Ser-Cys-Pro-Pro-Trp-Gln-Glu-Trp-His-Asn-Phe-Met-Pro-Phe-NH2 (Cy5.5-Aoc-EGBP) was evaluated for use with in vivo near-infrared (NIR) fluorescence imaging in mice with EGFR-positive tumors.	Histidine	60-63	epidermal growth factor receptor	Mus musculus	194-198
9579727-16	1998	The effect of 500 mg kg(-1) L-histidine was completely prevented by the selective histidine decarboxylase inhibitor, (S)-alpha-fluoromethylhistidine (50 mg kg(-1), i.p.	Histidine	28-39	histidine decarboxylase	Mus musculus	82-105
22490985-6	2012	Sequence analysis of the coding region of the SCN5A gene, identified a G to A heterozygous missense mutation at nucleotide site 2066 that resulted in a amino-acid substitution of arginine to histidine at amino-acid site 689 (R689H).	Histidine	191-200	sodium voltage-gated channel alpha subunit 5	Homo sapiens	46-51
3796733-4	1986	Analysis of the amino-acid sequence of TFIIIA revealed nine similar domains of approximately 30 amino acids, each containing two invariant pairs of histidines and cysteines, which have been implicated as possible binding sites for the zinc atoms.	Histidine	148-158	general transcription factor 3A L homeolog	Xenopus laevis	39-45
3796733-6	1986	Here, we report the results of an EXAFS (extended X-ray absorption fine structure) study of TFIIIA which shows that the coordination sphere of the zinc sites consists of two cysteine and two histidine residues.	Histidine	191-200	general transcription factor 3A L homeolog	Xenopus laevis	92-98
9713284-0	1998	Expression of abnormal transcripts of the FHIT (fragile histidine triad) gene in ovarian carcinoma.	Histidine	56-65	fragile histidine triad diadenosine triphosphatase	Homo sapiens	42-46
3091083-1	1986	The histidine derivative diphthamide occurs uniquely in eukaryotic elongation factor 2 (EF-2), and is the specific target for the diphtheria toxin mono(ADP-ribosyl)transferase.	Histidine	4-13	eukaryotic translation elongation factor 2	Mus musculus	67-86
3091083-1	1986	The histidine derivative diphthamide occurs uniquely in eukaryotic elongation factor 2 (EF-2), and is the specific target for the diphtheria toxin mono(ADP-ribosyl)transferase.	Histidine	4-13	eukaryotic translation elongation factor 2	Mus musculus	88-92
3091083-2	1986	The first step in diphthamide biosynthesis may involve the transfer of aminocarboxypropyl moiety from S-adenosylmethionine to the imidazole ring of histidine in EF-2, to yield 2-(3-carboxy-3-aminopropyl)histidine and 5"-deoxy-5"-methylthioadenosine (MeSAdo).	Histidine	148-157	eukaryotic translation elongation factor 2	Mus musculus	161-165
3720741-1	1986	Active-site histidine residues of bovine seminal RNase have been found to react with bromoacetic acid and with 2"(3")-O-bromoacetyluridine (BrAcUrd) at a much faster rate than free histidine.	Histidine	12-21	seminal ribonuclease	Bos taurus	41-54
3720741-1	1986	Active-site histidine residues of bovine seminal RNase have been found to react with bromoacetic acid and with 2"(3")-O-bromoacetyluridine (BrAcUrd) at a much faster rate than free histidine.	Histidine	181-190	seminal ribonuclease	Bos taurus	41-54
22780202-0	2012	Viscoelasticity of thin biomolecular films: a case study on nucleoporin phenylalanine-glycine repeats grafted to a histidine-tag capturing QCM-D sensor.	Histidine	115-124	ArfGAP with FG repeats 2	Homo sapiens	60-71
22904127-5	2012	We detected 31 (41.9%) heterozygous IDH1 mutations resulting in arginine-to-histidine substitution (R132H;CGT-CAT).	Histidine	76-85	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	36-40
9713284-1	1998	To elucidate the role of the FHIT (fragile histidine triad) gene in ovarian carcinogenesis, the expression of the gene was analysed by reverse transcription-polymerase chain reaction (RT-PCR) in 51 cases of ovarian carcinoma, 6 cases of borderline tumour and 4 cases of benign ovarian tumour.	Histidine	43-52	fragile histidine triad diadenosine triphosphatase	Homo sapiens	29-33
9480926-3	1998	Treatment of CPT-II with the histidine-selective reagent, diethyl pyrocarbonate (DEPC), resulted in simple linear pseudo-first-order kinetics.	Histidine	29-38	carnitine palmitoyltransferase 2	Homo sapiens	13-19
21812836-10	2012	The concomittant presence of low concentrations of histidine, alanine and either glycine or pyrrolidone-5-carboxylic acid (PCA) in the SC was associated with FLG mutations with 92% specificity.	Histidine	51-60	filaggrin	Homo sapiens	158-161
22863590-5	2012	RESULTS: Recombinant His-AKR7A5 was successfully purified as confirmed by SDS-PAGE and Western blotting.	Histidine	21-24	aldo-keto reductase family 7, member A5 (aflatoxin aldehyde reductase)	Mus musculus	25-31
9480926-5	1998	The order of the inactivation kinetics showed that 1mol of histidine was modified per mol of CPT-II.	Histidine	59-68	carnitine palmitoyltransferase 2	Homo sapiens	93-99
22240897-3	2012	Here, we repot that golgi-specific Asp-His-His-Cys (DHHC) zinc finger protein (GODZ) regulates TRAIL/DR4-mediated apoptosis.	Histidine	39-42	zinc finger DHHC-type palmitoyltransferase 3	Homo sapiens	79-83
3539098-6	1986	The histidine and arginine residues implicated as being important for the activity of yeast enolase are conserved in the chicken enzyme.	Histidine	4-13	enolase 3 (beta, muscle)	Gallus gallus	92-99
9499091-7	1998	In the case of Cys-, Leu-, Asn-, Gln-, or Arg-nsP4, revertants that were indistinguishable in plaque phenotype from the wild-type virus arose by same-site reversion to Tyr, Trp, Phe, or His by a single nucleotide substitution in the original mutant codon.	Histidine	186-189	serine protease 57	Homo sapiens	46-50
3537709-6	1986	The effect of gcd5 is a posttranscriptional increase in histidine biosynthetic enzyme activity.	Histidine	56-65	lysine--tRNA ligase KRS1	Saccharomyces cerevisiae S288C	14-18
9541386-4	1998	The overall structure of murine CAIV is generally similar to that of human CAIV; however, some local structural differences are found in the active site resulting from amino acid sequence differences in the "130"s segment" and the residue-63 loop (these may affect the nearby catalytic proton shuttle, His-64).	Histidine	302-305	carbonic anhydrase 4	Mus musculus	32-36
22434504-6	2012	The activity of gp74 in the presence of Ni(2+)  is significantly decreased below neutral pH, suggesting the presence of one or more His residues in metal binding and/or DNA digestion.	Histidine	132-135	Gp74	Escherichia phage HK97	16-20
22542587-5	2012	Most of the expressed human ATAD3A-Myc-HIS co-purified with the yeast mitochondrial fraction thus suggesting that targeting to this organelle is preserved in yeast.	Histidine	39-42	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	35-38
22542587-8	2012	By contrast, urea-denaturated ATAD3A-Myc-HIS bound to agarose-nickel beads and could be renatured and eluted to obtain highly pure ATAD3A-Myc-HIS.	Histidine	41-44	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	37-40
22542587-8	2012	By contrast, urea-denaturated ATAD3A-Myc-HIS bound to agarose-nickel beads and could be renatured and eluted to obtain highly pure ATAD3A-Myc-HIS.	Histidine	41-44	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	138-141
3956484-7	1986	It is proposed that the Ser-Phe combination present in L16, L11 and L6 is involved in transesterification in addition to the single histidine in L16.	Histidine	132-141	immunoglobulin kappa variable 3D-15	Homo sapiens	55-58
3956484-7	1986	It is proposed that the Ser-Phe combination present in L16, L11 and L6 is involved in transesterification in addition to the single histidine in L16.	Histidine	132-141	immunoglobulin kappa variable 3D-15	Homo sapiens	145-148
9468479-0	1998	Identification of histidine 45 as the axial heme iron ligand of heme oxygenase-2.	Histidine	18-27	heme oxygenase 2	Homo sapiens	64-80
3956484-8	1986	The single histidine in L16 appears to be important in the catalysis of peptide bond formation and transesterification.	Histidine	11-20	immunoglobulin kappa variable 3D-15	Homo sapiens	24-27
22468687-5	2012	Additionally these membranes isolate His-tagged COP9 signalosome complex subunit 8 from cell extracts and show &gt;90% recovery of His-tagged ubiquitin.	Histidine	37-40	COP9 signalosome subunit 8	Homo sapiens	48-52
22468687-5	2012	Additionally these membranes isolate His-tagged COP9 signalosome complex subunit 8 from cell extracts and show &gt;90% recovery of His-tagged ubiquitin.	Histidine	131-134	COP9 signalosome subunit 8	Homo sapiens	48-52
3471106-1	1986	We report dynamic simulations of the process by which a dioxygen molecule enters or leaves the heme pocket region of myoglobin along a path between the distal histidine (E7) and valine (E11).	Histidine	159-168	myoglobin	Homo sapiens	117-126
9461622-8	1998	Moreover, recombinant M1Pase is subject to active site-directed, hydroxylamine-reversible inhibition by the histidine-selective acylating reagent diethyl pyrocarbonate.	Histidine	108-117	ETH_00027300	Eimeria tenella	22-28
3027598-3	1986	Copper, complexed to histidine (CuHis), stimulates LHRH release from explants of the median eminence area (MEA).	Histidine	21-30	gonadotropin releasing hormone 1	Rattus norvegicus	51-55
22181833-4	2012	We found that not only lysine but also arginine and histidine bound well, and when present with an additional proximal positive charge, accounted for about half of the total binding energy of a protein ligand such as PAI-1 (plasminogen activator inhibitor-1).	Histidine	52-61	serpin family E member 1	Homo sapiens	217-222
22181833-4	2012	We found that not only lysine but also arginine and histidine bound well, and when present with an additional proximal positive charge, accounted for about half of the total binding energy of a protein ligand such as PAI-1 (plasminogen activator inhibitor-1).	Histidine	52-61	serpin family E member 1	Homo sapiens	224-257
9461622-9	1998	These results indicate the presence of an essential histidine residue(s) at the M1Pase active site, as predicted for a histidine phosphatase.	Histidine	52-61	ETH_00027300	Eimeria tenella	80-86
9426066-5	1998	Only two alterations, both at codon 24, have been identified in CDK4: an activating arginine-to-cysteine transition and a germ-line arginine-to-histidine substitution in one French kindred.	Histidine	144-153	cyclin dependent kinase 4	Homo sapiens	64-68
22541546-9	2012	The method used to purify rBdh-2 was affinity chromatography on a His-Trap column following ion-exchange chromatography on a DEAE-Sephacel column.	Histidine	66-69	3-hydroxybutyrate dehydrogenase 2	Rattus norvegicus	26-32
22186895-3	2011	We reveal that this occurs because of a single amino acid difference at position 435, where IgG3 has an arginine instead of the histidine found in all other IgG subclasses.	Histidine	128-137	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	92-96
22131323-3	2011	Divalent cations Zn(2+), Cu(2+) and Ni(2+) inhibit Ca(V)3.2 channels more efficiently than Ca(V)3.1 and Ca(V)3.3 channels via second high-affinity binding site including histidine H191 specific for the Ca(V)3.2 channel.	Histidine	170-179	immunoglobulin lambda variable 7-43	Homo sapiens	51-59
3905974-6	1985	Both [32P] phosphate and [3H]histidine were incorporated into the high-Mr band after pulse labeling for 3 h. After a 15-h chase, [3H]histidine, but not [32P]phosphate appeared in filaggrin.	Histidine	133-142	filaggrin	Homo sapiens	179-188
3905974-11	1985	These studies suggest that human skin filaggrin, like rodent filaggrin, is synthesized as a high-Mr, phosphorylated, histidine-rich precursor (profilaggrin) that is processed via posttranslational modification to filaggrin.	Histidine	117-126	filaggrin	Homo sapiens	38-47
9633819-0	1998	Different missense mutations in histidine-108 of lysosomal acid lipase cause cholesteryl ester storage disease in unrelated compound heterozygous and hemizygous individuals.	Histidine	32-41	lipase A, lysosomal acid type	Homo sapiens	49-70
2863142-7	1985	The results suggested essential tryptophan, lysine and histidine residues at a common catalytic site for pseudocholinesterase and aryl acylamidase and an arginine residue (or residues) exclusively for pseudocholinesterase.	Histidine	55-64	butyrylcholinesterase	Homo sapiens	105-125
21900231-6	2011	We also employed structure-based mutagenesis; the results support the importance of the alpha-amino methionine-specific pocket of Naa50p and are consistent with the proposal that conserved histidine and tyrosine residues play important catalytic roles.	Histidine	189-198	N-alpha-acetyltransferase 50, NatE catalytic subunit	Homo sapiens	130-136
21757694-2	2011	Carboxyl-terminally His-FLAG-tagged human P2X1 receptors were stably expressed in HEK293 cells and co-purified with cytoskeletal proteins including actin.	Histidine	20-23	purinergic receptor P2X 1	Homo sapiens	42-46
9461294-0	1997	Three-dimensional solution structure of human angiogenin determined by 1H,15N-NMR spectroscopy--characterization of histidine protonation states and pKa values.	Histidine	116-125	angiogenin	Homo sapiens	46-56
21768284-3	2011	The pneumococcal genome encodes two conserved proteins of an as yet unknown function, SP1298 and SP2205, classified as DHH (Asp-His-His) subfamily 1 proteins.	Histidine	128-131	desert hedgehog	Mus musculus	119-122
21768284-3	2011	The pneumococcal genome encodes two conserved proteins of an as yet unknown function, SP1298 and SP2205, classified as DHH (Asp-His-His) subfamily 1 proteins.	Histidine	132-135	desert hedgehog	Mus musculus	119-122
3923165-4	1985	Serum somatomedin (Sm) activity was significantly decreased in lysine- (0.55 U/ml), methionine- (0.32 U/ml) and histidine-deficient (0.38 U/ml) rats compared to rats fed the control diet ad libitum (1.6 U/ml).	Histidine	112-121	insulin-like growth factor 1	Rattus norvegicus	6-17
9401074-1	1997	Recently the FHIT gene (fragile histidine triad gene) has been identified at chromosome 3p14.2 and a high frequency of abnormalities in this gene has been demonstrated in various cancers.	Histidine	32-41	fragile histidine triad diadenosine triphosphatase	Homo sapiens	13-17
6203787-1	1984	The identification of PHI (the 27-amino acid peptide (P) having an N-terminal histidine (H) and a C-terminal isoleucine amide (I] in median eminence suggested that PHI influences the secretory function of the anterior pituitary.	Histidine	78-87	glucose-6-phosphate isomerase	Rattus norvegicus	22-25
6203787-1	1984	The identification of PHI (the 27-amino acid peptide (P) having an N-terminal histidine (H) and a C-terminal isoleucine amide (I] in median eminence suggested that PHI influences the secretory function of the anterior pituitary.	Histidine	78-87	glucose-6-phosphate isomerase	Rattus norvegicus	164-167
6362724-11	1984	Enhanced absorption effects in the two histidines (B5 and B10) of the insulin monomer were observed at pH 10 in the presence of 0.1 M phosphate.	Histidine	39-49	insulin	Bos taurus	70-77
21882401-12	2004	A DOTA-Gly-benzoyl group was added to the C-terminus to form DOTA-Gly-benzoyl-d-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2 (RM1).	Histidine	104-107	GCY	Homo sapiens	108-111
21680741-7	2011	These data indicated that His-396 is important for the formation of the C4a-hydroperoxy-FMN intermediate but is not involved in H(2)O(2) elimination.	Histidine	26-29	formin 1	Homo sapiens	88-91
21680741-11	2011	The double mutant S171A/H396V reacted with oxygen to directly form the oxidized flavin without stabilizing the C4a-hydroperoxy-FMN intermediate, which confirmed the findings based on the single mutation that His-396 was important for formation and Ser-171 for stabilization of the C4a-hydroperoxy-FMN intermediate in C(2).	Histidine	208-211	complement C4A (Rodgers blood group)	Homo sapiens	281-284
21680741-11	2011	The double mutant S171A/H396V reacted with oxygen to directly form the oxidized flavin without stabilizing the C4a-hydroperoxy-FMN intermediate, which confirmed the findings based on the single mutation that His-396 was important for formation and Ser-171 for stabilization of the C4a-hydroperoxy-FMN intermediate in C(2).	Histidine	208-211	formin 1	Homo sapiens	297-300
9497501-6	1997	Second, IF1 possesses a histidine-rich region in the same area, which is thought to be important for regulation of mammalian inhibitors.	Histidine	24-33	ATP synthase inhibitory factor subunit 1	Homo sapiens	8-11
9354703-6	1997	Sf9 cells infected with the histidine-tagged NaSi-1 or untagged NaSi-1 protein expressed sodium-dependent sulfate cotransport up to 60-fold higher compared to noninfected cells.	Histidine	28-37	solute carrier family 13 member 1	Homo sapiens	45-51
21659509-8	2011	Mutations of two alpha, two beta, and two gamma His residues within extracellular domains significantly reduced the inhibition of human ENaC by Cu(2+).	Histidine	48-51	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	136-140
21680735-6	2011	Furthermore, exchange of His-88, mediating an intramolecular H(+)-shuttle in CAIV, to alanine resulted only in a slight decrease in CAIV-mediated augmentation of MCT2 activity.	Histidine	25-28	carbonic anhydrase 4 gene 1 S homeolog	Xenopus laevis	77-81
21680735-6	2011	Furthermore, exchange of His-88, mediating an intramolecular H(+)-shuttle in CAIV, to alanine resulted only in a slight decrease in CAIV-mediated augmentation of MCT2 activity.	Histidine	25-28	carbonic anhydrase 4 gene 1 S homeolog	Xenopus laevis	132-136
6329161-1	1984	Preparations of horse heart cytochrome c have been obtained immobilized on Sepharose derivatives via lysine epsilon-amino groups, carboxyl groups of aspartic and glutamic acid residues, methionine and histidine residues as well as imidazole groups additionally introduced by means of modification of free carboxyl groups by histamine.	Histidine	201-210	cytochrome c, somatic	Equus caballus	28-40
6689645-1	1984	We have recently described the ability of abrupt short-to-long changes in atrial cycle length (CL) to prolong refractoriness of the His-Purkinje system (HPS) and increase the likelihood of aberrant ventricular conduction.	Histidine	132-135	doublecortin like kinase 3	Homo sapiens	95-97
6335884-1	1984	L-Histidine (L-His) and human serum albumin (HSA) at physiological concentrations, like the exogenous ligands D-penicillamine (D-PEN) and EDTA, are shown to inhibit the uptake of physiological levels of Ni2+ by B-lymphoblasts of human origin, human erythrocytes and rabbit alveolar macrophages.	Histidine	0-11	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	129-132
21673098-6	2011	The role of the dipeptides His-Ala and Tyr-Ala as DPP-4-generated GLP-1 and glucose-dependent insulinotropic peptide (GIP) degradation products was studied in vivo and in vitro on isolated islets.	Histidine	27-30	dipeptidylpeptidase 4	Mus musculus	50-55
9336452-2	1997	Three of these genes (mR-3, mR-4, mR-5) include complete open reading frames, encoding ribonucleases with eight cysteines and appropriately spaced histidines (His11 and His124) and lysine (Lys35) that are characteristic of this enlarging protein family; the fourth sequence encodes a non-functional pseudogene (mR-6P).	Histidine	147-157	eosinophil-associated, ribonuclease A family, member 3	Mus musculus	22-32
21680522-10	2011	We generated several E1B-55K mutants with mutations at positions occupied by the conserved Phe/Trp/His residues.	Histidine	99-102	small nucleolar RNA, H/ACA box 73A	Homo sapiens	21-24
9367815-4	1997	The ratio of recovery of the pure active recombinant protein was better when the purification of the protein was made easier by addition of a short His-Tag at the C-terminal moiety of AADC, as achieved in the case of pET-20b+ vector expression.	Histidine	148-151	dopa decarboxylase	Rattus norvegicus	184-188
21549153-5	2011	There was a significant difference in HI antibody levels (P&lt;0.05) elicited by either rFPV-HA or rFPV-HA/IL18.	Histidine	38-40	interleukin 18	Gallus gallus	107-111
6200430-4	1984	RF-AN is reactive with IgG1, 2, 4 and IgG3m (15,16) proteins having histidine at 435.	Histidine	68-77	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	38-42
6091699-1	1983	Preparations of horse heart cytochrome c have been obtained immobilized on Sepharose derivatives via lysine epsilon-amino groups, carboxyl groups of aspartic and glutamic acid residues, methionine and histidine residues as well as imidazole groups additionally introduced by means of chemical modification of free carboxyl groups by histamine.	Histidine	201-210	cytochrome c, somatic	Equus caballus	28-40
9352462-2	1997	In vitro, peptide Piv-His-Pro-Phe-His-Leu-psi[CH(OH)CH2]Leu-Tyr-Tyr-Ser-NH2(XXI) is the most potent inhibitor of rat plasma renin reported having an IC50 of 0.21 nM; it is a much weaker inhibitor of human renin (IC50 45 nM).	Histidine	22-25	renin	Rattus norvegicus	124-129
9352462-2	1997	In vitro, peptide Piv-His-Pro-Phe-His-Leu-psi[CH(OH)CH2]Leu-Tyr-Tyr-Ser-NH2(XXI) is the most potent inhibitor of rat plasma renin reported having an IC50 of 0.21 nM; it is a much weaker inhibitor of human renin (IC50 45 nM).	Histidine	34-37	renin	Rattus norvegicus	124-129
9352462-3	1997	Peptide Boc-His-Pro-Phe-His-Leu-psi[CH(OH)CH2] Leu-Val-Ile-His-NH2 (XX) was a highly effective inhibitor of rat renin in vivo.	Histidine	12-15	renin	Rattus norvegicus	112-117
6409092-14	1983	Myosin, examined at both pH 5.7 and 6.7, exhibited generally similar behaviour, there being losses of other amino acid residues as well as histidine: the viscosity was decreased to a low value, and a range of peptides of widely varying size was produced.	Histidine	139-148	myosin heavy chain 14	Homo sapiens	0-6
21619030-3	2011	Attachment of a His tag to the N-terminus of the robust globular protein myoglobin leads to only minor changes to the electrostatic environment of the heme pocket, as evinced by the nearly unchanged Fourier transform infrared spectrum of CO bound to the heme of His-tagged myoglobin.	Histidine	16-19	myoglobin	Homo sapiens	73-82
21619030-3	2011	Attachment of a His tag to the N-terminus of the robust globular protein myoglobin leads to only minor changes to the electrostatic environment of the heme pocket, as evinced by the nearly unchanged Fourier transform infrared spectrum of CO bound to the heme of His-tagged myoglobin.	Histidine	16-19	myoglobin	Homo sapiens	273-282
9352462-3	1997	Peptide Boc-His-Pro-Phe-His-Leu-psi[CH(OH)CH2] Leu-Val-Ile-His-NH2 (XX) was a highly effective inhibitor of rat renin in vivo.	Histidine	24-27	renin	Rattus norvegicus	112-117
21619030-3	2011	Attachment of a His tag to the N-terminus of the robust globular protein myoglobin leads to only minor changes to the electrostatic environment of the heme pocket, as evinced by the nearly unchanged Fourier transform infrared spectrum of CO bound to the heme of His-tagged myoglobin.	Histidine	262-265	myoglobin	Homo sapiens	73-82
9352462-3	1997	Peptide Boc-His-Pro-Phe-His-Leu-psi[CH(OH)CH2] Leu-Val-Ile-His-NH2 (XX) was a highly effective inhibitor of rat renin in vivo.	Histidine	24-27	renin	Rattus norvegicus	112-117
6411645-1	1983	Titration curves of the histidine residues in lutropin, thyrotropin, follitropin and chorionic gonadotropin have been assigned using imidazole C-2 proton nuclear magnetic resonance spectra and their estimated pK values determined.	Histidine	24-33	complement C2	Homo sapiens	143-146
9290961-1	1997	The FHIT (fragile histidine triad) gene has been isolated from the chromosome region 3p14.2, which includes the fragile site locus FRA3B and the breakpoint of the t(3;8) of familial renal carcinoma.	Histidine	18-27	fragile histidine triad diadenosine triphosphatase	Homo sapiens	4-8
6339504-9	1983	These results are in accord with the proposed structure of diphthamide and suggest that in its biosynthesis the backbone and 3 methyl groups of methionine are added to a histidine residue in the peptide chain of EF-2.	Histidine	170-179	elongation factor 2	Saccharomyces cerevisiae S288C	212-216
21574551-1	2011	ZIF268, a member of the classical zinc finger protein family, contains three Cys(2)His(2) zinc binding domains that together recognize the DNA sequence 5"-AGCGTGGGCGT-3".	Histidine	83-86	early growth response 1	Homo sapiens	0-6
9290961-1	1997	The FHIT (fragile histidine triad) gene has been isolated from the chromosome region 3p14.2, which includes the fragile site locus FRA3B and the breakpoint of the t(3;8) of familial renal carcinoma.	Histidine	18-27	fragile histidine triad diadenosine triphosphatase	Homo sapiens	131-136
9223530-3	1997	The integrity of the helicase function is dependent on the conserved DEAD motif and can be abolished by a His-Ala point mutation, leaving a fully functional nucleoside triphosphatase.	Histidine	106-109	helicase for meiosis 1	Homo sapiens	21-29
21377473-8	2011	We propose a model of the tetrahedral coordination of a Zn(2+) by (Cys)(3)His residues that is compatible with SS2 formation in S100A3.	Histidine	74-77	S100 calcium binding protein A3	Homo sapiens	128-134
6291931-3	1982	The C-2 and C-4 proton resonances of the active-center histidine His-36 could be identified; the pK of His-36 was determined as 6.1.	Histidine	55-64	complement C2	Homo sapiens	4-7
6291931-3	1982	The C-2 and C-4 proton resonances of the active-center histidine His-36 could be identified; the pK of His-36 was determined as 6.1.	Histidine	55-64	complement C4A (Rodgers blood group)	Homo sapiens	12-15
6291931-3	1982	The C-2 and C-4 proton resonances of the active-center histidine His-36 could be identified; the pK of His-36 was determined as 6.1.	Histidine	65-68	complement C2	Homo sapiens	4-7
6291931-3	1982	The C-2 and C-4 proton resonances of the active-center histidine His-36 could be identified; the pK of His-36 was determined as 6.1.	Histidine	65-68	complement C4A (Rodgers blood group)	Homo sapiens	12-15
6291931-3	1982	The C-2 and C-4 proton resonances of the active-center histidine His-36 could be identified; the pK of His-36 was determined as 6.1.	Histidine	103-106	complement C2	Homo sapiens	4-7
6291931-3	1982	The C-2 and C-4 proton resonances of the active-center histidine His-36 could be identified; the pK of His-36 was determined as 6.1.	Histidine	103-106	complement C4A (Rodgers blood group)	Homo sapiens	12-15
21443971-6	2011	In both cases, His-tHBP-HA shows similar apparent K(m) and apparent V(max) values.	Histidine	15-18	trans-o-hydroxybenzylidenepyruvate hydratase-aldolase	Pseudomonas fluorescens	19-26
21443971-7	2011	Further analyses showed that the optimal pH and temperature of His-tHBP-HA activity are 7.0 and 30 C, respectively.	Histidine	63-66	trans-o-hydroxybenzylidenepyruvate hydratase-aldolase	Pseudomonas fluorescens	67-74
9218440-6	1997	Our previous studies have identified a mutation at position 332 within Drosophila TBP that changes a highly conserved arginine residue to a histidine residue, which renders it specifically defective in its ability to support RNA polymerase III transcription in S-2 cells (Trivedi, A., Vilalta, A., Gopalan, S., and Johnson, D. L. (1996) Mol.	Histidine	140-149	TATA binding protein	Drosophila melanogaster	82-85
21531294-14	2011	In the untreated group, intense uptake of His(10)-annexin V was visualized in the defect which was shown in MPI, whereas in the adenosine group a mild uptake of (99m)Tc-His(10)-annexin was found in the risk area which showed no defects in the (99m)Tc-MIBI image.	Histidine	42-45	annexin A5	Homo sapiens	50-59
21531294-17	2011	Uptake of His(10)-annexin V in RI correlated with TUNEL-positive nuclei.	Histidine	10-13	annexin A5	Homo sapiens	18-27
9211872-8	1997	PDI/beta polypeptide containing a histidine tag in its N terminus was found to form prolyl 4-hydroxylase tetramers as readily as the wild-type PDI/beta polypeptide, and histidine-tagged forms of prolyl 4-hydroxylase appear to offer an excellent source for a simple large scale purification of the recombinant enzyme.	Histidine	34-43	prolyl 4-hydroxylase subunit beta	Homo sapiens	0-3
21375246-0	2011	Model peptides provide new insights into the role of histidine residues as potential ligands in human cellular copper acquisition via Ctr1.	Histidine	53-62	solute carrier family 31 member 1	Homo sapiens	134-138
7104374-5	1982	Inhibition of lipoprotein lipase by benzene boronic acid is likely to be due to the formation of an inhibitor-enzyme complex having analogous bonding to the active site histidine and serine as the transition-state complex which precedes the formation of an obligatory acyl-enzyme intermediate.	Histidine	169-178	lipoprotein lipase	Homo sapiens	14-32
21375246-3	2011	Unlike yeast, mammalian Ctr1 also contains extracellular histidine-rich motifs, although a role for these regions in copper uptake has not been explored in detail.	Histidine	57-66	solute carrier family 31 member 1	Homo sapiens	24-28
9289426-7	1997	This mechanism involves GCN4-independent activation of expression of genes of purine and histidine metabolism.	Histidine	89-98	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	24-28
21375246-6	2011	These model studies suggest that the histidine domains may play a direct role in copper acquisition from serum copper-binding proteins and in facilitating the reduction of Cu(II) to the active Ctr1 substrate, Cu(I).	Histidine	37-46	solute carrier family 31 member 1	Homo sapiens	193-197
21375246-8	2011	Results from live cell studies support the hypothesis that extracellular amino-terminal His residues directly participate in the copper transport function of Ctr1.	Histidine	88-91	solute carrier family 31 member 1	Homo sapiens	158-162
6297137-1	1982	Chemical modification of a histidine and lysine residue inactivates pea seed nucleoside diphosphate kinase (NDP kinase).	Histidine	27-36	cytidine/uridine monophosphate kinase 2	Homo sapiens	77-106
6297137-1	1982	Chemical modification of a histidine and lysine residue inactivates pea seed nucleoside diphosphate kinase (NDP kinase).	Histidine	27-36	cytidine/uridine monophosphate kinase 2	Homo sapiens	108-118
6297137-2	1982	Thus there seems to be a reactive lysine residue, at the active site of pea seed NDP kinase, in addition to the histidine residue phosphorylated by the substrate ATP as a consequence of the enzyme reaction.	Histidine	112-121	cytidine/uridine monophosphate kinase 2	Homo sapiens	81-91
9225464-5	1997	A repeated domain was identified within the predicted 3AF1 amino acid sequence, which includes a series of histidines and cysteines, suggestive of zinc binding, and this repeat is conserved in E4/E8BP-1.	Histidine	107-117	peptide methionine sulfoxide reductase	Solanum lycopersicum	193-200
7288634-6	1981	Structural analysis with fingerprint mapping of the hemoglobin beta chain after pretreatment with cysteine and histidine blocking agents such as p-nitrophenacyl bromide, 2-bromoethylamine hydrobromide and diethylprocarbonate indicated that the 2,3-epoxide preferentially binds to the cysteinyl residue, whereas the 3,4-epoxide binds to the histidinyl residue.	Histidine	111-120	hemoglobin subunit beta	Homo sapiens	52-67
21324305-10	2011	One possible candidate could be the histidine-rich C-terminal domain of PCSK9.	Histidine	36-45	proprotein convertase subtilisin/kexin type 9	Homo sapiens	72-77
21074618-4	2011	The secreted single chain murine soluble CD40L monomers, dimers, and trimers were initially enriched through histidine tag capture by Ni-Sepharose 6 fast flow resin and further purified on a cation exchange resin.	Histidine	109-118	CD40 ligand	Mus musculus	41-46
9148890-8	1997	A mutant JEM1p carrying a mutation in the highly conserved His-Pro-Asp sequence in the J-domain could not complement either temperature-sensitive growth of the Deltajem1 Deltascj1 double mutant or defects in karyogamy of the Deltajem1 mutant.	Histidine	59-62	Jem1p	Saccharomyces cerevisiae S288C	9-14
21167151-5	2011	The intake of histidine or carnosine significantly diminished the activity and mRNA expression of malic enzyme, FAS, HMG-CoA reductase, SREBP-1c and SREBP-2, which led to lower body weight, epididymal fat, and hepatic triglyceride and cholesterol levels (P&lt;0.05).	Histidine	14-23	sterol regulatory element binding transcription factor 1	Mus musculus	136-144
6167582-4	1981	The C4a anaphylatoxin is a cationic polypeptide of Mr = 9000 composed of 77 residues and devoid of histidine, tryptophan, and carbohydrate.	Histidine	99-108	complement C4A (Rodgers blood group)	Homo sapiens	4-7
7019446-1	1981	Metabolic breakdown of the luteinizing hormone-releasing hormone (LH-RH) could lead to the following fragments containing pyroglutamic acid: pyroglutamic acid (1), pGlu-His (2), pGLu-His-Trp (3), pGlu-His-Trp-Ser (4), etc., and finally pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly (10).	Histidine	183-186	gonadotropin releasing hormone 1	Rattus norvegicus	27-64
7019446-1	1981	Metabolic breakdown of the luteinizing hormone-releasing hormone (LH-RH) could lead to the following fragments containing pyroglutamic acid: pyroglutamic acid (1), pGlu-His (2), pGLu-His-Trp (3), pGlu-His-Trp-Ser (4), etc., and finally pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly (10).	Histidine	183-186	gonadotropin releasing hormone 1	Rattus norvegicus	66-71
7306027-12	1981	In isolated stratum corneum, the residual histidine can be converted into urocanic acid by the histidine ammonia-lyase in the tissue only if the natural acidity of the tissue is neutralized.	Histidine	42-51	histidine ammonia-lyase	Cavia porcellus	95-118
20641535-0	2004	(111)In-DOTA-Gly-benzoyl-D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2 The amphibian bombesin (BBN or BN, a peptide of 14 amino acids) is an analog of human gastrin-releasing peptide (GRP, a peptide of 27 amino acids) that binds to GRP receptors (GRPR) with high affinity and specificity (1).	Histidine	51-54	GCY	Homo sapiens	55-58
20641535-12	2004	DOTA-Gly-benzoyl group was added to the C-terminus to form DOTA-Gly-benzoyl-D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2 (RM1).	Histidine	102-105	GCY	Homo sapiens	106-109
9175718-5	1997	Inactivation of glutathione reductase by alpha,beta-unsaturated aldehydes was followed by slower NADPH-independent reactions that led to formation of nonfluorescent cross-linked products, accompanied by loss of lysine and histidine residues.	Histidine	222-231	glutathione-disulfide reductase	Homo sapiens	16-37
21628886-5	2011	Twelve metabolites in mesencephalon of S100B transgenic mice were identified as potential biomarkers, among which, glutamic acid (Glu) detected by RP/MS in negative ionization mode, gamma-aminobutyric acid (GABA) and tryptophan (Trp) detected by HILIC/MS in positive ionization mode, phenylalanine (Phe) and histidine (His) detected by HILIC/MS in negative ionization mode, related to metabolic pathway of neurotransmitters in mice central nervous system.	Histidine	308-317	S100 protein, beta polypeptide, neural	Mus musculus	39-44
21628886-5	2011	Twelve metabolites in mesencephalon of S100B transgenic mice were identified as potential biomarkers, among which, glutamic acid (Glu) detected by RP/MS in negative ionization mode, gamma-aminobutyric acid (GABA) and tryptophan (Trp) detected by HILIC/MS in positive ionization mode, phenylalanine (Phe) and histidine (His) detected by HILIC/MS in negative ionization mode, related to metabolic pathway of neurotransmitters in mice central nervous system.	Histidine	319-322	S100 protein, beta polypeptide, neural	Mus musculus	39-44
6164624-1	1981	The N-terminal sequence 1-10 of interferon HuIFN-alpha(Ly) from human lymphoblasts Ser-Asp-Leu-Pro-Gln-Thr-His-Ser-Leu-Gly (LIF[1-10]) was synthesized by the Merrifield method.	Histidine	107-110	LIF interleukin 6 family cytokine	Homo sapiens	124-127
6821370-5	1980	The binding of Co(II) to the mono-zinc(II)-enzyme caused only one marked change in the spectrum, namely a decrease in the intensity of the resonances assigned to the C-2 and C-4 protons of one histidine residue (residue E).	Histidine	193-202	complement C2	Homo sapiens	166-169
6821370-5	1980	The binding of Co(II) to the mono-zinc(II)-enzyme caused only one marked change in the spectrum, namely a decrease in the intensity of the resonances assigned to the C-2 and C-4 protons of one histidine residue (residue E).	Histidine	193-202	complement C4A (Rodgers blood group)	Homo sapiens	174-177
6987229-0	1980	Primary structure of a histidine-rich proteolytic fragment of human ceruloplasmin.	Histidine	23-32	ceruloplasmin	Homo sapiens	68-81
6987229-2	1980	A histidine-rich fragment, Cp F5, with a molecular weight of 18,650 was isolated from human ceruloplasmin.	Histidine	2-11	ceruloplasmin	Homo sapiens	92-105
9045649-4	1997	Functional recombinant RF-C containing p40-his, p37-his, or p36-his was isolated using affinity resin.	Histidine	43-46	interleukin 9	Homo sapiens	39-42
6987230-0	1980	Primary structure of a histidine-rich proteolytic fragment of human ceruloplasmin.	Histidine	23-32	ceruloplasmin	Homo sapiens	68-81
6987230-3	1980	Amino acid sequence studies of tryptic peptides isolated from a histidine-rich fragment (Cp F5) of human ceruloplasmin are described.	Histidine	64-73	ceruloplasmin	Homo sapiens	105-118
21966400-0	2011	Fibrillization of human tau is accelerated by exposure to lead via interaction with His-330 and His-362.	Histidine	96-99	microtubule associated protein tau	Homo sapiens	24-27
21966400-8	2011	The results from isothermal titration calorimetry show that one Pb(2+) binds to one Tau monomer via interaction with His-330 and His-362, with sub-micromolar affinity.	Histidine	117-120	microtubule associated protein tau	Homo sapiens	84-87
21966400-8	2011	The results from isothermal titration calorimetry show that one Pb(2+) binds to one Tau monomer via interaction with His-330 and His-362, with sub-micromolar affinity.	Histidine	129-132	microtubule associated protein tau	Homo sapiens	84-87
21966400-9	2011	CONCLUSIONS/SIGNIFICANCE: We demonstrate for the first time that the fibrillization of human Tau protein is accelerated by exposure to lead via interaction with His-330 and His-362.	Histidine	161-164	microtubule associated protein tau	Homo sapiens	93-96
21966400-9	2011	CONCLUSIONS/SIGNIFICANCE: We demonstrate for the first time that the fibrillization of human Tau protein is accelerated by exposure to lead via interaction with His-330 and His-362.	Histidine	173-176	microtubule associated protein tau	Homo sapiens	93-96
21208569-2	2011	METHODS: The recombinant expression plasmid pET32a-His-PCGF1-128/189 was made and transformed into E.coli (BL21), and then the recombinant fusion protein His-PCGF1-128/189 was expressed and purified.	Histidine	51-54	polycomb group ring finger 1	Homo sapiens	55-60
21208569-2	2011	METHODS: The recombinant expression plasmid pET32a-His-PCGF1-128/189 was made and transformed into E.coli (BL21), and then the recombinant fusion protein His-PCGF1-128/189 was expressed and purified.	Histidine	51-54	polycomb group ring finger 1	Homo sapiens	158-163
21208569-2	2011	METHODS: The recombinant expression plasmid pET32a-His-PCGF1-128/189 was made and transformed into E.coli (BL21), and then the recombinant fusion protein His-PCGF1-128/189 was expressed and purified.	Histidine	154-157	polycomb group ring finger 1	Homo sapiens	55-60
115864-2	1979	An enzyme which catalyzes the deamidation of thyroliberin (TRF; less than Glu-His-Pro-NH2) has been purified 110-fold from extracts of bovine anterior pituitary by ammonium sulfate fractionation, ion exchange chromatography on DEAE-cellulose, and gel filtration.	Histidine	78-81	interleukin 5	Bos taurus	59-62
21208569-8	2011	RESULTS: The recombinant protein His-PCGF1-128/189 was expressed and purified.	Histidine	33-36	polycomb group ring finger 1	Homo sapiens	37-42
9085937-2	1997	Thus, the mature IFN-alpha2a protein product is characterized by a lysine residue at position 23 (AAA) and a histidine at position 34 (CAA), IFN-alpha2b has an arginine at position 23 (AGA) and histidine at position 34 (CAT), and IFN-alpha2c has arginine residues at both positions 23 (AGA) and 34 (CGT).	Histidine	194-203	interferon alpha 2	Homo sapiens	17-27
20884616-3	2010	We previously showed that NDPK-B activates the K(+) channel KCa3.1 via histidine phosphorylation of the C terminus of KCa3.1, which is required for T cell receptor-stimulated Ca(2+) flux and proliferation of activated naive human CD4 T cells.	Histidine	71-80	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	26-32
41713-0	1979	Proton-nuclear-magnetic-resonance/pH-titration studies of the histidines of pancreatic phospholipase A2.	Histidine	62-72	LOC104974671	Bos taurus	87-103
41713-1	1979	The study by means of 1H nuclear magnetic resonance (NMR) of the histidines of phospholipase A2 isolated from porcine, bovine and equine pancreas is reported.	Histidine	65-75	LOC104974671	Bos taurus	79-95
9023081-3	1997	On SDS gels the recombinant hydra LBP displayed an apparent molecular mass of 43 kDa, although the calculated mass, including six additional histidines, is 33.7 kDa.	Histidine	141-151	galectin 3	Homo sapiens	34-37
83954-0	1978	The effect of L-thyroxine, antithyroid substances and L-histidine on either form of catalase in guinea pig liver and brain.	Histidine	54-65	catalase	Cavia porcellus	84-92
20828147-12	2010	Finally, we show that the mutant of His alpha-syn with all five proline residues mutated to alanine is more structured (more alpha-helix) than His-WT alpha-syn, indicating the role of the Pro residues as potential helix breakers in the inhibitory conformation of the C-terminus.	Histidine	36-39	synuclein alpha	Homo sapiens	40-49
20828147-12	2010	Finally, we show that the mutant of His alpha-syn with all five proline residues mutated to alanine is more structured (more alpha-helix) than His-WT alpha-syn, indicating the role of the Pro residues as potential helix breakers in the inhibitory conformation of the C-terminus.	Histidine	36-39	synuclein alpha	Homo sapiens	150-159
410450-6	1977	As with bovine alpha-lactalbumin, at pH 2.7, 2-hydroxy-5-nitrobenzyl bromide is specific for tryptophan but at pH 7 His-32 also reacts.	Histidine	116-119	lactalbumin alpha	Bos taurus	15-32
9041627-5	1997	The binding of the C4B isotype, and most likely C3, to hydroxyl nucleophiles, however, involves a histidine residue, which attacks the thioester to form an intramolecular acyl-imidazole bond.	Histidine	98-107	complement C4B (Chido blood group)	Homo sapiens	19-22
16883-0	1977	Magnetic resonance studies of concanavalin A: assignment of histidine resonances in 220 MHz proton spectrum of complexes with Co2+ and Zn2+.	Histidine	60-69	complement C2	Homo sapiens	126-129
20978114-4	2010	Here, we uncover an MLH1 clinical mutation with a leucine (L)-to-histidine (H) amino acid change at position 607 that ablates MLH1 binding to FANCJ.	Histidine	65-74	mutL homolog 1	Homo sapiens	20-24
20978114-4	2010	Here, we uncover an MLH1 clinical mutation with a leucine (L)-to-histidine (H) amino acid change at position 607 that ablates MLH1 binding to FANCJ.	Histidine	65-74	mutL homolog 1	Homo sapiens	126-130
20978114-4	2010	Here, we uncover an MLH1 clinical mutation with a leucine (L)-to-histidine (H) amino acid change at position 607 that ablates MLH1 binding to FANCJ.	Histidine	65-74	BRCA1 interacting helicase 1	Homo sapiens	142-147
20594158-2	2010	However, GLP-1 is rapidly degraded to GLP-1(9-36) by dipeptidyl peptidase-IV (DPP-IV), which removes the N-terminal dipeptide His(7)-Ala(8).	Histidine	126-129	dipeptidylpeptidase 4	Mus musculus	53-76
9002937-3	1997	The observation that a common functional polymorphism of Fc gamma RIIA, involving either an arginine (R) or histidine (H) at amino acid 131, may underlie disease susceptibility prompted us to investigate the prevalence of receptor isoforms in patients with HIT and HITT.	Histidine	108-117	Fc gamma receptor IIa	Homo sapiens	57-70
20594158-2	2010	However, GLP-1 is rapidly degraded to GLP-1(9-36) by dipeptidyl peptidase-IV (DPP-IV), which removes the N-terminal dipeptide His(7)-Ala(8).	Histidine	126-129	dipeptidylpeptidase 4	Mus musculus	78-84
16883-3	1977	The magnitude of these shifts can be used to determine the orientation of axis of anisotropy of the Co2+ ligand field since the distances from the C2 protons of the histidines to S1 can be computed from the crystal structure coordinates.	Histidine	165-175	complement C2	Homo sapiens	100-103
9238644-3	1997	The histidine-epsilon-amino caproic acid-beta-alanine-histidine (His-epsilon Ahx-beta Ala-His) sequence was found to yield optimal inhibition of both MMP-2 and MMP-9.	Histidine	65-68	matrix metallopeptidase 2	Homo sapiens	150-155
1004498-3	1976	The proteins studied essentially regained their native structures after the treatment, except for broadening and shifting of the histidine resonances in the case of alpha-lactalbumin.	Histidine	129-138	lactalbumin alpha	Bos taurus	165-182
20847263-5	2010	We used mass spectrometry to show that the phosphate from PEP is transferred to the catalytic histidine (His11) on human PGAM1.	Histidine	94-103	phosphoglycerate mutase 1	Homo sapiens	121-126
20847263-7	2010	The presence of histidine-phosphorylated PGAM1 correlated with the expression of PKM2 in cancer cell lines and tumor tissues.	Histidine	16-25	phosphoglycerate mutase 1	Homo sapiens	41-46
20847263-7	2010	The presence of histidine-phosphorylated PGAM1 correlated with the expression of PKM2 in cancer cell lines and tumor tissues.	Histidine	16-25	pyruvate kinase M1/2	Homo sapiens	81-85
20847263-8	2010	Thus, decreased pyruvate kinase activity in PKM2-expressing cells allows PEP-dependent histidine phosphorylation of PGAM1 and may provide an alternate glycolytic pathway that decouples adenosine triphosphate production from PEP-mediated phosphotransfer, allowing for the high rate of glycolysis to support the anabolic metabolism observed in many proliferating cells.	Histidine	87-96	pyruvate kinase M1/2	Homo sapiens	44-48
20847263-8	2010	Thus, decreased pyruvate kinase activity in PKM2-expressing cells allows PEP-dependent histidine phosphorylation of PGAM1 and may provide an alternate glycolytic pathway that decouples adenosine triphosphate production from PEP-mediated phosphotransfer, allowing for the high rate of glycolysis to support the anabolic metabolism observed in many proliferating cells.	Histidine	87-96	phosphoglycerate mutase 1	Homo sapiens	116-121
9016654-3	1996	TIF1 beta, TIF1 alpha, PML and efp belong to a characteristic subgroup of RING finger proteins that contain one or two other Cys/His-rich clusters (B boxes) and a putative coiled-coil in addition to the classical C3HC4 RING finger motif (RBCC configuration).	Histidine	129-132	tripartite motif containing 25	Homo sapiens	31-34
8937850-5	1996	The yield of His-P-PST from the pET-15b vector was improved 12-fold, compared with P-PST from the original vector.	Histidine	13-16	sulfotransferase family 1A member 1	Homo sapiens	17-22
20720509-8	2010	Increased AQP4 andalpha-syntrophin levels were inhibited by L-histidine, an inhibitor of glutamine transport into mitochondria, suggesting a role for glutamine in the increase of PM levels of AQP4.	Histidine	60-71	aquaporin 4	Rattus norvegicus	10-14
20720509-8	2010	Increased AQP4 andalpha-syntrophin levels were inhibited by L-histidine, an inhibitor of glutamine transport into mitochondria, suggesting a role for glutamine in the increase of PM levels of AQP4.	Histidine	60-71	aquaporin 4	Rattus norvegicus	192-196
20715989-2	2010	USP17 has highly conserved Cys, His, and Asp domains responsible for the deubiquitinating activity, and two hyaluronan binding motifs in its sequence.	Histidine	32-35	ubiquitin specific peptidase 17 like family member 9, pseudogene	Homo sapiens	0-5
1237492-4	1975	This group is considered to be responsible for the low pH inflection with pKa 4.2 present in the NMR titration curve of the C-2 proton resonance of histidine 48.	Histidine	148-157	complement C2	Homo sapiens	124-127
53066-4	1975	End group analysis of human antithrombin II/III shows histidine as the N-terminal amino acid.	Histidine	54-63	serpin family C member 1	Homo sapiens	28-47
8937850-8	1996	The sulfonation of several substrates was very similar for His-P-PST and P-PST, with Vmax/KM values (first order rate constants) for the high-affinity substrate p-nitrophenol of 143 +/- 27 and 120 +/- 25 ml min-1 microgram-1 PST [mean +/- SE; not significant (NS)], respectively, and for the low-affinity substrate acetaminophen of 0.21 +/- 0.11 and 0.14 +/- 0.07 ml min-1 microgram-1 PST (NS).	Histidine	59-62	sulfotransferase family 1A member 1	Homo sapiens	63-68
8937850-9	1996	The Vmax/KM for the sulfonation of the isoproterenol enantiomers showed a (+)/(-)-enantiomer ratio of 6.2 for His-P-PST and 7.4 for P-PST.	Histidine	110-113	sulfotransferase family 1A member 1	Homo sapiens	114-119
1165251-3	1975	The proximal histidine of the globins and two adjacent helices are equivalent to the sixth iron ligand and adjacent helices of cytochrome b5.	Histidine	13-22	cytochrome b5 type A	Homo sapiens	127-140
20484158-9	2010	In addition, we find that His(132), Val(134), and Asn(141) in human ssTnI, previously identified as enabling contractile function during cellular acidosis, are present in all vertebrate cTnI isoforms except those from monotremes, marsupials, and eutherian mammals.	Histidine	26-29	troponin I1, slow skeletal type	Homo sapiens	68-73
8937850-12	1996	The additional amino acid residues in the His-P-PST, compared with the recombinant P-PST, thus did not significantly alter the catalytic properties.	Histidine	42-45	sulfotransferase family 1A member 1	Homo sapiens	46-51
8910340-6	1996	This binding was inhibited by the replacement in p202 of a histidine (from the M(F/L)HATVA(T/S) sequence that is conserved among all of the 200 family proteins) by phenylalanine.	Histidine	59-68	interferon activated gene 202B	Mus musculus	49-53
20382256-0	2010	The conserved histidine in epidermal growth factor-like domains of stabilin-2 modulates pH-dependent recognition of phosphatidylserine in apoptotic cells.	Histidine	14-23	stabilin 2	Homo sapiens	67-77
20382256-6	2010	The PS binding activity of stabilin-2 is enhanced in low pH, and a conserved histidine(1403) in close proximity to the PS binding loop is critical for pH-dependent activity.	Histidine	77-86	stabilin 2	Homo sapiens	27-37
20382256-7	2010	We propose that protonation of His(1403) may rearrange the PS binding loop to enhance binding affinity in low pH, indicating that acidic pH might act as a danger signal to stimulate stabilin-2-mediated phagocytosis to resolve inflammation.	Histidine	31-34	stabilin 2	Homo sapiens	182-192
20460111-7	2010	In this study we show, that denuded IQ2 favours a closed conformation of myosin with a low HIS-MLC-1 binding affinity.	Histidine	91-94	myosin heavy chain 14	Homo sapiens	73-79
4590450-0	1973	The role of histidine residues in yeast hexokinase.	Histidine	12-21	hexokinase	Saccharomyces cerevisiae S288C	40-50
4515001-1	1973	The thermal denaturation of ribonuclease A has been studied by use of Fourier transform nuclear magnetic resonance by monitoring the imidazole C-2 proton resonances of the histidine residues as a function of temperature at pH 1.3.	Histidine	172-181	complement C2	Homo sapiens	143-146
8798701-0	1996	Characterization of histidine residues essential for receptor binding and activity of nerve growth factor.	Histidine	20-29	nerve growth factor	Rattus norvegicus	86-105
20436286-4	2010	Mutation of conserved motif C cysteines and histidines disrupted the association of Dbf4 with ARS1 origin DNA and Mcm2, but not other known ligands including Cdc7, Rad53 or the origin recognition complex subunit Orc2.	Histidine	44-54	MCM DNA helicase complex subunit MCM2	Saccharomyces cerevisiae S288C	114-118
8798701-4	1996	Slight perturbations in circular dichroism spectra and weakened self-association of the mutants indicated that His-75 and His-84 may be involved in stability, dimerization, and/or folding of NGF.	Histidine	111-114	nerve growth factor	Rattus norvegicus	191-194
8798701-4	1996	Slight perturbations in circular dichroism spectra and weakened self-association of the mutants indicated that His-75 and His-84 may be involved in stability, dimerization, and/or folding of NGF.	Histidine	122-125	nerve growth factor	Rattus norvegicus	191-194
20194481-8	2010	The rs540825 polymorphism is a nonsynonymous SNP in the final exon of the mu-opioid receptor-1X isoform of the OPRM1 gene, resulting in a histidine to glutamine change in the intracellular domain of the receptor.	Histidine	138-147	opioid receptor mu 1	Homo sapiens	111-116
8798701-12	1996	At least three and possibly all four histidines, which are located in three spatially distinct regions, contribute to maintenance of functional sites that are essential for receptor binding and activity of NGF.	Histidine	37-47	nerve growth factor	Rattus norvegicus	206-209
19697087-6	2010	Treatment of undeveloped ovarian explant cultures with recombinant histidine (His)-RPL10a stimulated the expression of translationally controlled tumor protein (TCTP), heat shock protein 70 (HSP70), and shrimp ovarian peritrophin (SOP) genes, previously shown to be involved in ovarian maturation.	Histidine	67-76	tumor protein, translationally-controlled 1	Homo sapiens	119-159
21153109-0	1996	Effects of TRH and TRH-like peptide pGLU-HIS-GLY-NH(2) on adrenocortical cell proliferation in rats.	Histidine	41-44	thyrotropin releasing hormone	Rattus norvegicus	19-22
19697087-6	2010	Treatment of undeveloped ovarian explant cultures with recombinant histidine (His)-RPL10a stimulated the expression of translationally controlled tumor protein (TCTP), heat shock protein 70 (HSP70), and shrimp ovarian peritrophin (SOP) genes, previously shown to be involved in ovarian maturation.	Histidine	67-76	tumor protein, translationally-controlled 1	Homo sapiens	161-165
19697087-6	2010	Treatment of undeveloped ovarian explant cultures with recombinant histidine (His)-RPL10a stimulated the expression of translationally controlled tumor protein (TCTP), heat shock protein 70 (HSP70), and shrimp ovarian peritrophin (SOP) genes, previously shown to be involved in ovarian maturation.	Histidine	78-81	tumor protein, translationally-controlled 1	Homo sapiens	119-159
19697087-6	2010	Treatment of undeveloped ovarian explant cultures with recombinant histidine (His)-RPL10a stimulated the expression of translationally controlled tumor protein (TCTP), heat shock protein 70 (HSP70), and shrimp ovarian peritrophin (SOP) genes, previously shown to be involved in ovarian maturation.	Histidine	78-81	tumor protein, translationally-controlled 1	Homo sapiens	161-165
13346044-7	1956	It involves the exposure of 1 new acid-binding group per mole of rhodopsin with pK about 6.6, close therefore to that of the imidazole group of histidine.	Histidine	144-153	rhodopsin	Bos taurus	65-74
8809067-11	1996	G beta phosphorylation was confirmed by immunoprecipitation with G beta-specific antibodies, and the target amino acid was identified as histidine.	Histidine	137-146	succinate-CoA ligase GDP-forming subunit beta	Homo sapiens	0-6
33998793-4	2021	Here we report a pH increase during fibril formation of alpha-synuclein, observed using three complementary experimental methods: pH electrode measurements in water; colorimetric changes of a fluorescent indicator; and chemical shift changes for histidine residues using solution state NMR spectroscopy.	Histidine	246-255	synuclein alpha	Homo sapiens	56-71
20099820-0	2010	Binding of histidine in the (Cys)3(His)1-coordinated [2Fe-2S] cluster of human mitoNEET.	Histidine	11-20	CDGSH iron sulfur domain 1	Homo sapiens	79-87
20099820-6	2010	Simulation and least-squares fitting of orientation-selective Ka- and Q-band ENDOR, 1D ESEEM, and HYSCORE spectra of (14)N and (15)N-labeled mitoNEET yield the principal values and orientations of both the hyperfine tensor ((14)N, A(iso) = -6.25 MHz, T = -0.94 MHz) and the quadrupolar tensor (e(2)Qq/h = -2.47 MHz, eta = 0.38) of the ligating histidine nitrogen N(delta).	Histidine	344-353	CDGSH iron sulfur domain 1	Homo sapiens	141-149
8718865-6	1996	The ability of bleomycin hydrolase to oligomerize was neither affected by the subtle cysteine/serine mutation nor affected by cysteine/arginine or histidine/glycine mutations.	Histidine	147-156	bleomycin hydrolase	Saccharomyces cerevisiae S288C	15-34
19875381-5	2010	We further characterized a novel ADP-dependent HSP90 interaction with the cysteine- and histidine-rich domain (CHORD)-containing protein CHORDC1.	Histidine	88-97	heat shock protein 90 alpha family class A member 1	Homo sapiens	47-52
19940152-3	2010	A histidine at position 191 was recently identified as a critical determinant for both trace metal block of Ca(v)3.2 and modulation by redox agents.	Histidine	2-11	immunoglobulin lambda variable 7-43	Homo sapiens	108-116
34032179-8	2021	We propose that His-190 may play a role in the hydrolysis of pyrophosphate from GTP and in releasing the product, DARP.	Histidine	16-19	ankyrin repeat domain 23	Homo sapiens	114-118
8702701-5	1996	The results showed that two sites in PTH and PTHrP fully account for the different potencies that the two ligands exhibited with PTH-2 receptors; residue 5 (His in PTHrP and Ile in PTH) determined signaling capability, while residue 23 (Phe in PTHrP and Trp in PTH) determined binding affinity.	Histidine	157-160	parathyroid hormone like hormone	Homo sapiens	45-50
33975942-7	2021	The DnaK/DnaJ/DksA complex enables the formation of an enzymatically active RNA polymerase holoenzyme that stimulates transcription of branched-chain amino acid and histidine metabolic genes in Salmonella exposed to reactive oxygen species.	Histidine	165-174	DnaJ	Escherichia coli	9-13
19940152-5	2010	Mutation of the corresponding residue in Ca(v)3.1 to histidine, Gln(172), significantly enhances trace metal inhibition, but not to the level observed in wild-type Ca(v)3.2, implying that other residues also contribute to the metal binding site.	Histidine	53-62	immunoglobulin lambda variable 7-43	Homo sapiens	164-172
8702701-5	1996	The results showed that two sites in PTH and PTHrP fully account for the different potencies that the two ligands exhibited with PTH-2 receptors; residue 5 (His in PTHrP and Ile in PTH) determined signaling capability, while residue 23 (Phe in PTHrP and Trp in PTH) determined binding affinity.	Histidine	157-160	parathyroid hormone like hormone	Homo sapiens	164-169
8702701-5	1996	The results showed that two sites in PTH and PTHrP fully account for the different potencies that the two ligands exhibited with PTH-2 receptors; residue 5 (His in PTHrP and Ile in PTH) determined signaling capability, while residue 23 (Phe in PTHrP and Trp in PTH) determined binding affinity.	Histidine	157-160	parathyroid hormone like hormone	Homo sapiens	164-169
20057140-6	2010	The C-terminal catalytic segment of the human Frk kinase conjugating hexahistidine purification tag (His-tag) was expressed in Escherichia coli.	Histidine	101-104	fyn related Src family tyrosine kinase	Homo sapiens	46-49
8706892-2	1996	We overexpressed MoaA from pAO1 of Arthrobacter nicotinovorans in Escherichia coli as a N-terminal fusion with either glutathione-S-transferase or a 6-histidine tag.	Histidine	151-160	moaA	Paenarthrobacter nicotinovorans	17-21
19566844-6	2010	Intracerebroventricular injection of L-histidine (0.01 microg / 5 microL) also caused a decrease in MAP, which was reversed by cotreatment with the histamine H3 receptor antagonist thioperamide (20.4 microg / 5 microL, i.c.v.).	Histidine	37-48	histamine receptor H3	Rattus norvegicus	148-169
33887099-2	2021	Unusually, AspH employs two histidine residues to chelate Fe(II) rather than the typical triad of two histidine and one glutamate/aspartate residue.	Histidine	28-37	aspartate beta-hydroxylase	Homo sapiens	11-15
33887099-2	2021	Unusually, AspH employs two histidine residues to chelate Fe(II) rather than the typical triad of two histidine and one glutamate/aspartate residue.	Histidine	102-111	aspartate beta-hydroxylase	Homo sapiens	11-15
33887099-3	2021	We report kinetic, inhibition, and crystallographic studies concerning human AspH variants in which either of its Fe(II) binding histidine residues are substituted for alanine.	Histidine	129-138	aspartate beta-hydroxylase	Homo sapiens	77-81
8764101-2	1996	Recently, we have cloned the FHIT (fragile histidine triad) gene, located at 3p14.2.	Histidine	43-52	fragile histidine triad diadenosine triphosphatase	Homo sapiens	29-33
33881737-4	2021	RESULTS: The sugars mannitol, sucrose and trehalose, and the amino acids Arg, Lys, and His significantly promote the oxidation of peptide Met to peptide Met sulfoxide.	Histidine	87-90	SAFB like transcription modulator	Homo sapiens	138-141
33881737-4	2021	RESULTS: The sugars mannitol, sucrose and trehalose, and the amino acids Arg, Lys, and His significantly promote the oxidation of peptide Met to peptide Met sulfoxide.	Histidine	87-90	SAFB like transcription modulator	Homo sapiens	153-156
33625414-8	2021	The interaction of the complexes with human transferrin (hTf) proteins was studied through molecular docking calculations, suggesting favorable binding through histidine residues and possible internalization into cancer cells via TfR-mediated endocytosis.	Histidine	160-169	coagulation factor III, tissue factor	Homo sapiens	57-60
19860422-6	2009	Electron transfer to protonated HAL and AHL triggers an exothermic and dynamically barrierless transfer of the carboxyl proton onto the C-2" position of the His ring that occurs on a 120-240 ns time scale.	Histidine	157-160	complement C2	Homo sapiens	136-139
19860422-11	2009	These radicals undergo proton migrations to the His ring C-5" positions that have moderate energy barriers and are less efficient.	Histidine	48-51	complement C5	Homo sapiens	57-60
19758826-4	2009	We propose that this newly discovered unstable M-hemoglobin (M-Hb) variant, named Hb Dothan [GGT/GAG-->GAG//Gly/Glu-->Glu], is caused by a shift in the amino acid sequence and altered packing of the B and E helices during beta globin synthesis, and also changes the orientation of the critical proximal and distal histidine in the F and E helices respectively.	Histidine	314-323	hemoglobin subunit beta	Homo sapiens	222-233
8663175-5	1996	Furthermore, the AT2 receptor agonist N-alpha-nicotinoyl-Tyr-Lys-(N-alphaCBZ-Arg)-His-Pro-Ile-OH (CGP42112A) (10-50 nM) caused significant decreases in neuronal Erk1 and Erk2 activities, which were abolished by PD 123319 (1 microM) and by the PP2A inhibitor okadaic acid (3 nM).	Histidine	82-85	angiotensin II receptor, type 2	Rattus norvegicus	17-20
19669174-0	2009	Reactivity of platinum-based antitumor drugs towards a Met- and His-rich 20mer peptide corresponding to the N-terminal domain of human copper transporter 1.	Histidine	64-67	solute carrier family 31 member 1	Homo sapiens	135-155
19669174-3	2009	In the work reported here, we constructed a Met- and His-rich 20mer peptide (hCtr1-N20) corresponding to the N-terminal domain of hCtr1, which is the essential domain of hCtr1 for transporting platinum drugs.	Histidine	53-56	solute carrier family 31 member 1	Homo sapiens	77-82
19669174-3	2009	In the work reported here, we constructed a Met- and His-rich 20mer peptide (hCtr1-N20) corresponding to the N-terminal domain of hCtr1, which is the essential domain of hCtr1 for transporting platinum drugs.	Histidine	53-56	solute carrier family 31 member 1	Homo sapiens	130-135
19669174-3	2009	In the work reported here, we constructed a Met- and His-rich 20mer peptide (hCtr1-N20) corresponding to the N-terminal domain of hCtr1, which is the essential domain of hCtr1 for transporting platinum drugs.	Histidine	53-56	solute carrier family 31 member 1	Homo sapiens	130-135
8663175-5	1996	Furthermore, the AT2 receptor agonist N-alpha-nicotinoyl-Tyr-Lys-(N-alphaCBZ-Arg)-His-Pro-Ile-OH (CGP42112A) (10-50 nM) caused significant decreases in neuronal Erk1 and Erk2 activities, which were abolished by PD 123319 (1 microM) and by the PP2A inhibitor okadaic acid (3 nM).	Histidine	82-85	mitogen activated protein kinase 3	Rattus norvegicus	161-165
8663175-5	1996	Furthermore, the AT2 receptor agonist N-alpha-nicotinoyl-Tyr-Lys-(N-alphaCBZ-Arg)-His-Pro-Ile-OH (CGP42112A) (10-50 nM) caused significant decreases in neuronal Erk1 and Erk2 activities, which were abolished by PD 123319 (1 microM) and by the PP2A inhibitor okadaic acid (3 nM).	Histidine	82-85	mitogen activated protein kinase 1	Rattus norvegicus	170-174
8647857-7	1996	A combination of two mutations, Ile99 --&gt; His and Ser200 --&gt; Pro, converted P450 2C9 to an enzyme with a turnover number of omeprazole 5-hyrdroxylation, which resembled that of P450 /c19.	Histidine	45-48	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	82-86
19684018-6	2009	Using a series of hCTR1 mutants, we show that cleavage occurs preferentially between residues Ala(29)-Ser(30)-His(31).	Histidine	110-113	solute carrier family 31 member 1	Homo sapiens	18-23
8647857-7	1996	A combination of two mutations, Ile99 --&gt; His and Ser200 --&gt; Pro, converted P450 2C9 to an enzyme with a turnover number of omeprazole 5-hyrdroxylation, which resembled that of P450 /c19.	Histidine	45-48	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	183-187
8631881-6	1996	Identification of a second mouse gene highly homologous to NZF-1, encoded by a distinct genomic locus, reveals a dispersed gene family encoding proteins containing Cys-Cys, His-Cys motifs.	Histidine	173-176	myelin transcription factor 1-like	Mus musculus	59-64
19783046-9	2009	Domains I and II, in particular a histidine residue within Ca(V)3.2 (H191), are responsible for the subtype-prevalent N(2)O inhibition.	Histidine	34-43	immunoglobulin lambda variable 7-43	Homo sapiens	59-67
8622873-6	1996	The mutations are located within the Cys/His-rich regions, which are assumed to play important roles in the function of p300.	Histidine	41-44	E1A binding protein p300	Homo sapiens	120-124
19736979-1	2009	CW EPR spectra of reduced [2Fe-2S](Cys)(3)(His)(1) clusters of mammalian mitoNEET soluble domain appear to produce features resulting from the interaction of the electron spins of the two adjacent clusters, which can be explained by employing the local spin model.	Histidine	43-46	CDGSH iron sulfur domain 1	Homo sapiens	73-81
19757839-2	2009	The substitution of the His(4)-Pro(5) dipeptide sequence by the constrained Trp analogue Aia-Gly, in combination with beta(2)hVal substitution at the N-terminus, provided a new stable analogue H-(R)-beta(2)hVal-Tyr-Ile-Aia-Gly-Phe-OH (AL-40) that is a potent ligand for the Ang IV receptor IRAP and selective versus AP-N and the AT1 receptor.	Histidine	24-27	interleukin 1 receptor antagonist	Homo sapiens	290-294
19767579-5	2009	Mmp-20 cleaves amelogenin sequences after Pro(162), Ser(148), His(62), Ala(63), and Trp(45).	Histidine	62-65	amelogenin	Sus scrofa	15-25
8743562-7	1996	The N-terminal amino acid sequence of MTSP-1 was Ile-Val-Gly-Gly-Tyr-Thr-His-Leu-Asp-Asn-Gln-Val-Pro-Tyr.	Histidine	73-76	suppression of tumorigenicity 14 (colon carcinoma)	Mus musculus	38-44
19535453-5	2009	In the CD4-bound conformation, the highly conserved histidine 66 is located between the receptor-binding and gp41-interactive surfaces of gp120.	Histidine	52-61	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	138-143
19728931-6	2009	In this study, mouse FADD (80-205) containing DD domain and C-terminal region, designated as C-FADD, was expressed in E. coli with His-tag at the N-terminus and purified by Ni2+ affinity chromatography.	Histidine	131-134	Fas (TNFRSF6)-associated via death domain	Mus musculus	95-99
19728931-8	2009	In vitro His-tag pull-down assay demonstrated that the purified C-FADD possessed the CK Ialpha-binding activity which was important for its non-apoptotic function.	Histidine	9-12	Fas (TNFRSF6)-associated via death domain	Mus musculus	66-70
8601310-3	1996	CDK2 binds the Cks single domain conformation and interacts with conserved hydrophobic residues plus His-60 and Glu-63 in their closed beta-hinge motif conformation.	Histidine	101-104	cyclin dependent kinase 2	Homo sapiens	0-4
19389703-1	2009	This report addresses the functional role of His residues in the proton-coupled folate transporter (PCFT; SLC46A1), which mediates intestinal folate absorption.	Histidine	45-48	solute carrier family 46 member 1	Homo sapiens	106-113
8621424-5	1996	Here we show that the binding site of NT-3 to its non-preferred receptors TrkA and TrkB is dominated by two positively charged residues, Arg-31 and His-33, previously shown to constitute a main determinant of binding to p75LNGFR.	Histidine	148-151	neurotrophic receptor tyrosine kinase 1	Homo sapiens	74-78
8621424-5	1996	Here we show that the binding site of NT-3 to its non-preferred receptors TrkA and TrkB is dominated by two positively charged residues, Arg-31 and His-33, previously shown to constitute a main determinant of binding to p75LNGFR.	Histidine	148-151	neurotrophic receptor tyrosine kinase 2	Homo sapiens	83-87
19502167-2	2009	In this study, we investigated the influence of DNA methyltransferase 3b (DNMT3b) on fragile histidine trial (FHIT) expression and on DNA methylation of the FHIT promoter region in the hepatoma cell line SMMC-7721.	Histidine	93-102	DNA methyltransferase 3 beta	Homo sapiens	48-72
19502167-2	2009	In this study, we investigated the influence of DNA methyltransferase 3b (DNMT3b) on fragile histidine trial (FHIT) expression and on DNA methylation of the FHIT promoter region in the hepatoma cell line SMMC-7721.	Histidine	93-102	DNA methyltransferase 3 beta	Homo sapiens	74-80
9053785-1	1996	The present study was designed to examine the effects of intracerebroventricular injection of His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 (GHRP) on GH secretion in freely moving conscious male rats and to determine whether the central action of GHRP is mediated by increased GHRH and/or somatostatin (SRIF) release.	Histidine	94-97	growth hormone secretagogue receptor	Rattus norvegicus	127-131
19318355-3	2009	In the present study, we mapped the region of mouse ANGPTL4 recognized by mAb 14D12 to amino acids Gln(29)-His(53), which we designate as specific epitope 1 (SE1).	Histidine	107-110	angiopoietin-like 4	Mus musculus	52-59
19318355-3	2009	In the present study, we mapped the region of mouse ANGPTL4 recognized by mAb 14D12 to amino acids Gln(29)-His(53), which we designate as specific epitope 1 (SE1).	Histidine	107-110	granzyme A	Mus musculus	138-161
19318355-5	2009	Alignment of all angiopoietin family members revealed that a sequence similar to ANGPTL4 SE1 was present only in ANGPTL3, corresponding to amino acids Glu(32)-His(55).	Histidine	159-162	angiopoietin-like 4	Mus musculus	81-88
9053785-1	1996	The present study was designed to examine the effects of intracerebroventricular injection of His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 (GHRP) on GH secretion in freely moving conscious male rats and to determine whether the central action of GHRP is mediated by increased GHRH and/or somatostatin (SRIF) release.	Histidine	94-97	growth hormone secretagogue receptor	Rattus norvegicus	233-237
19318355-5	2009	Alignment of all angiopoietin family members revealed that a sequence similar to ANGPTL4 SE1 was present only in ANGPTL3, corresponding to amino acids Glu(32)-His(55).	Histidine	159-162	granzyme A	Mus musculus	89-92
9053785-1	1996	The present study was designed to examine the effects of intracerebroventricular injection of His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 (GHRP) on GH secretion in freely moving conscious male rats and to determine whether the central action of GHRP is mediated by increased GHRH and/or somatostatin (SRIF) release.	Histidine	94-97	growth hormone releasing hormone	Rattus norvegicus	263-267
8631326-6	1996	Protein mass fingerprinting with tryptic fragments identified p57 as a protein related to protein disulfide-isomerase which belongs to the superfamily of Cys-Gly-His-Cys-containing sequences.	Histidine	162-165	cyclin-dependent kinase inhibitor 1C	Rattus norvegicus	62-65
19413965-3	2009	We reasoned that histidine 562 in hERG1 could play an important structure-function role.	Histidine	17-26	potassium voltage-gated channel subfamily H member 2	Homo sapiens	34-39
8787920-0	1996	TEM-28 from an Escherichia coli clinical isolate is a member of the His-164 family of TEM-1 extended-spectrum beta-lactamases.	Histidine	68-71	hypothetical protein	Escherichia coli	86-91
19211747-5	2009	Histidine 66 is located within the gp41-interactive inner domain of gp120 and, in other studies, has been shown to decrease the sampling of the CD4-bound conformation by unliganded gp120.	Histidine	0-9	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	68-73
19211747-5	2009	Histidine 66 is located within the gp41-interactive inner domain of gp120 and, in other studies, has been shown to decrease the sampling of the CD4-bound conformation by unliganded gp120.	Histidine	0-9	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	181-186
8750797-5	1995	This ameliorating effect of histidine was abolished by alpha-fluoromethylhistidine, an inhibitor of histidine decarboxylase, suggesting that histidine itself has no such ameliorating effect.	Histidine	28-37	histidine decarboxylase	Mus musculus	100-123
18952181-6	2009	In this work, the putative trpE gene of M. tuberculosis H37Rv was expressed as a fusion protein with a 6x His-tag on the N-terminal (His-TrpE) in Escherichia coli.	Histidine	106-109	anthranilate synthase component I	Mycobacterium tuberculosis H37Rv	27-31
8750797-5	1995	This ameliorating effect of histidine was abolished by alpha-fluoromethylhistidine, an inhibitor of histidine decarboxylase, suggesting that histidine itself has no such ameliorating effect.	Histidine	73-82	histidine decarboxylase	Mus musculus	100-123
18952181-6	2009	In this work, the putative trpE gene of M. tuberculosis H37Rv was expressed as a fusion protein with a 6x His-tag on the N-terminal (His-TrpE) in Escherichia coli.	Histidine	133-136	anthranilate synthase component I	Mycobacterium tuberculosis H37Rv	27-31
8547483-3	1995	A six-histidine tag, which was coexpressed at the carboxyl terminus of re-mSP-10, provided the means for purification of re-mSP-10 by immobilized metal chelation affinity chromatography technique.	Histidine	6-15	acrosomal vesicle protein 1	Mus musculus	74-80
18952181-6	2009	In this work, the putative trpE gene of M. tuberculosis H37Rv was expressed as a fusion protein with a 6x His-tag on the N-terminal (His-TrpE) in Escherichia coli.	Histidine	133-136	anthranilate synthase component I	Mycobacterium tuberculosis H37Rv	137-141
18758694-1	2009	The full-length hNdrg2 cDNA-coded 357 amino acids was cloned and expressed in Escherichia coli strain DH5alpha as a 6x His-tagged protein.	Histidine	119-122	NDRG family member 2	Homo sapiens	16-22
19139268-2	2009	Using a heterologous expression cloning approach, we isolated beta4GalNAcTB together with beta4GalNAcTB pilot (GABPI), a multimembrane-spanning protein related to Asp-His-His-Cys (DHHC) proteins but lacking the DHHC consensus sequence.	Histidine	167-170	beta4GalNAcTB pilot	Drosophila melanogaster	111-116
8547483-3	1995	A six-histidine tag, which was coexpressed at the carboxyl terminus of re-mSP-10, provided the means for purification of re-mSP-10 by immobilized metal chelation affinity chromatography technique.	Histidine	6-15	acrosomal vesicle protein 1	Mus musculus	124-130
7562931-4	1995	These compounds inhibit HNE by forming both a covalent bond between the ketone carbonyl carbon atom and the hydroxyl group of Ser-195 and a hydrogen bond between the benzoxazole nitrogen atom and His-57.	Histidine	196-199	elastase, neutrophil expressed	Homo sapiens	24-27
19000777-9	2009	Moreover, mutagenesis studies showed crucial roles of His-154 and Cys-241 of rat iNAT in the catalysis and a possible role of the N-terminal domain in membrane association or protein-protein interaction.	Histidine	54-57	phospholipase A and acyltransferase 5	Rattus norvegicus	81-85
7673129-4	1995	AE1 protein was solubilized from yeast membranes with lysophosphatidyl choline, and the protein, tagged with six histidines at its amino terminus, was purified to 35% homogeneity by metal chelation affinity chromatography.	Histidine	113-123	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	0-3
19384417-5	2009	The FLG2 gene encodes a histidine- and glutamine-rich protein of approximately 248 kDa, which shares common structural features with other SFTP members, in particular filaggrin.	Histidine	24-33	filaggrin 2	Homo sapiens	4-8
19384417-5	2009	The FLG2 gene encodes a histidine- and glutamine-rich protein of approximately 248 kDa, which shares common structural features with other SFTP members, in particular filaggrin.	Histidine	24-33	filaggrin	Homo sapiens	167-176
33718276-4	2021	Our recent study has shown that ZIKV capsid protein interacted with Dicer and antagonized its endoribonuclease activity, which requires its histidine residue at the 41st amino acid.	Histidine	140-149	dicer 1, ribonuclease III	Homo sapiens	68-73
33468235-9	2021	GSEA revealed that butanoate metabolism, histidine metabolism, propanoate metabolism, pyruvate metabolism, tryptophan metabolism, PPAR signalling pathway, and renin-angiotensin system were differentially enriched in PHYH high-expression phenotype.	Histidine	41-50	phytanoyl-CoA 2-hydroxylase	Homo sapiens	216-220
19206287-1	2008	We have demonstrated that nanostructures, and in particular nanorings incorporating a homodimeric enzyme, can be prepared by chemically induced self-assembly of dihydrofolate reductase (DHFR)-histidine triad nucleotide binding 1 (Hint1) fusion proteins.	Histidine	192-201	dihydrofolate reductase	Homo sapiens	161-184
7653521-2	1995	NHE1 was protected by cimetidine and amiloride from DEPC, and DEPC inhibition was reversed with hydroxylamine, suggesting a role for critical histidine groups in NHE activity.	Histidine	142-151	solute carrier family 9 member C1	Homo sapiens	0-3
19206287-1	2008	We have demonstrated that nanostructures, and in particular nanorings incorporating a homodimeric enzyme, can be prepared by chemically induced self-assembly of dihydrofolate reductase (DHFR)-histidine triad nucleotide binding 1 (Hint1) fusion proteins.	Histidine	192-201	dihydrofolate reductase	Homo sapiens	186-190
7653521-7	1995	Kinetic analysis of DEPC inhibition indicated that two "critical" histidine residues are required for NHE transport activity.	Histidine	66-75	solute carrier family 9 member C1	Homo sapiens	102-105
7479707-0	1995	Phe-46(CD4) orients the distal histidine for hydrogen bonding to bound ligands in sperm whale myoglobin.	Histidine	31-40	myoglobin	Physeter catodon	94-103
18725328-5	2008	In addition, polymerization appears to depend on formation of the phosphoryl-Histidine intermediate of the enzyme, suggesting a previously unappreciated conformational change in NDPK during its catalytic cycle.	Histidine	77-86	cytidine/uridine monophosphate kinase 2	Homo sapiens	178-182
33320079-5	2021	IolQ was produced and purified as a C-terminal histidine (His)-tagged fusion protein in Escherichia coli and subjected to an in vitro gel electrophoresis mobility shift assay to examine its DNA-binding property.	Histidine	47-56	transcriptional regulator DegA	Bacillus subtilis	0-4
33320079-5	2021	IolQ was produced and purified as a C-terminal histidine (His)-tagged fusion protein in Escherichia coli and subjected to an in vitro gel electrophoresis mobility shift assay to examine its DNA-binding property.	Histidine	58-61	transcriptional regulator DegA	Bacillus subtilis	0-4
7479707-10	1995	In wild-type myoglobin, the van der Waals contact between C zeta of Phe-46 and C beta of His-64 appears to restrict rotation of the imidazole side chain.	Histidine	89-92	myoglobin	Physeter catodon	13-22
19008408-0	2008	Histidine at codon 154 of the prion protein gene is a risk factor for Nor98 scrapie in goats.	Histidine	0-9	major prion protein	Ovis aries	30-43
7612650-2	1995	A cDNA encoding rat bFGF was subcloned into the expression plasmid pQE-9 (Qiagen) in such a way that the bFGF which is produced from the resulting construct contains 6 histidine residues near the amino terminus.	Histidine	168-177	fibroblast growth factor 2	Rattus norvegicus	20-24
18952862-5	2008	Mutational analysis of Arabidopsis (Arabidopsis thaliana) DEG15 revealed that conserved histidine, aspartic acid, and serine residues are essential for the proteolytic activity of this enzyme in vitro.	Histidine	88-97	protease-like protein	Arabidopsis thaliana	58-63
33275641-5	2020	In addition, further analysis suggests that a histidine to glutamine mutation at residue number 197 can potentially allow the MMP8 protein to utilize Cu(II) in reactions.	Histidine	46-55	matrix metallopeptidase 8	Homo sapiens	126-130
32603918-6	2020	Myosin light chain (MYL1 and MYL3) showed high oxidative susceptibility owing to peptidyl methionine and proline oxidation as well as acetaldehyde adduct formation on lysine or histidine residues.	Histidine	177-186	myosin light chain 1	Homo sapiens	20-24
7612650-2	1995	A cDNA encoding rat bFGF was subcloned into the expression plasmid pQE-9 (Qiagen) in such a way that the bFGF which is produced from the resulting construct contains 6 histidine residues near the amino terminus.	Histidine	168-177	fibroblast growth factor 2	Rattus norvegicus	105-109
7782943-4	1995	We have developed an efficient histidine-tagged bacterial expression system that allows the folding and assembly of E1 alpha and E1 beta subunits into the E1 heterotetramer (alpha 2 beta 2) in the presence of overexpressed chaperonins GroEL and GroES.	Histidine	31-40	heat shock protein family E (Hsp10) member 1	Homo sapiens	245-250
33001366-6	2020	In this study we have developed a method for large-scale expression of Gal-1 and its histidine-tagged analog for use in binding studies by isothermal titration calorimetry (ITC) and development of an analytical method based on AlphaScreen technology to screen for Gal-1 inhibitors.	Histidine	85-94	galectin 1	Homo sapiens	71-76
33251782-2	2020	HbM-Milwaukee-2 is a rare variant caused by the point mutation CAC>TAC on codon 93 of the hemoglobin subunit beta (HBB) gene, resulting in the replacement of histidine by tyrosine.	Histidine	158-167	hemoglobin subunit beta	Homo sapiens	90-113
33251782-2	2020	HbM-Milwaukee-2 is a rare variant caused by the point mutation CAC>TAC on codon 93 of the hemoglobin subunit beta (HBB) gene, resulting in the replacement of histidine by tyrosine.	Histidine	158-167	hemoglobin subunit beta	Homo sapiens	115-118
33000160-4	2020	In mammals, l-histidine is rapidly incorporated into epidermal FLG and subsequent FLG proteolysis releases l-histidine as an important natural moisturizing factor (NMF).	Histidine	12-23	filaggrin	Homo sapiens	63-66
33000160-4	2020	In mammals, l-histidine is rapidly incorporated into epidermal FLG and subsequent FLG proteolysis releases l-histidine as an important natural moisturizing factor (NMF).	Histidine	12-23	filaggrin	Homo sapiens	82-85
18799458-7	2008	Structure-function analyses demonstrated that the C-terminal cysteine-histidine-rich domain of PCSK9 interacts specifically with the N-terminal repeat R1 of AnxA2.	Histidine	70-79	proprotein convertase subtilisin/kexin type 9	Homo sapiens	95-100
18799458-7	2008	Structure-function analyses demonstrated that the C-terminal cysteine-histidine-rich domain of PCSK9 interacts specifically with the N-terminal repeat R1 of AnxA2.	Histidine	70-79	annexin A2	Homo sapiens	157-162
18847225-1	2008	The release of ligand from the low-density lipoprotein receptor (LDLR) has been postulated to involve a "histidine switch"-induced intramolecular rearrangement that discharges bound ligand.	Histidine	105-114	low density lipoprotein receptor	Homo sapiens	31-63
18847225-1	2008	The release of ligand from the low-density lipoprotein receptor (LDLR) has been postulated to involve a "histidine switch"-induced intramolecular rearrangement that discharges bound ligand.	Histidine	105-114	low density lipoprotein receptor	Homo sapiens	65-69
18767117-8	2008	Supplementation of Lys, His, and Thr abrogated mTOR Ser 2448 phosphorylation, with no effect on Akt Ser 473-an mTORC2 target.	Histidine	24-27	mechanistic target of rapamycin kinase	Mus musculus	47-51
7890772-6	1995	EPR and Raman scattering studies indicated that a neutral imidazole of a histidine residue served as the proximal ligand in the heme-heme oxygenase-2 fragment complex.	Histidine	73-82	heme oxygenase 2	Homo sapiens	133-149
18767117-10	2008	The individual supplementation of Lys, His, and Thr maintained a low level of IRS-1 phosphorylation, which was dose-dependently increased by their combined addition.	Histidine	39-42	insulin receptor substrate 1	Mus musculus	78-83
19140321-4	2008	We first obtained antiserum to recombinant His-Xvent-2 and showed that the transcription factor Xvent-2 was present in eggs and embryos of Xenopus laevis from the cleavage up to the beginning of spontaneous motions (stage 26).	Histidine	43-46	VENT homeobox 2, gene 2 L homeolog	Xenopus laevis	47-54
19140321-4	2008	We first obtained antiserum to recombinant His-Xvent-2 and showed that the transcription factor Xvent-2 was present in eggs and embryos of Xenopus laevis from the cleavage up to the beginning of spontaneous motions (stage 26).	Histidine	43-46	VENT homeobox 2, gene 2 L homeolog	Xenopus laevis	96-103
33000160-4	2020	In mammals, l-histidine is rapidly incorporated into epidermal FLG and subsequent FLG proteolysis releases l-histidine as an important natural moisturizing factor (NMF).	Histidine	107-118	filaggrin	Homo sapiens	82-85
33000160-5	2020	It has therefore been hypothesized that l-histidine supplementation would be a safe approach to augment both FLG and the NMF, enhance skin barrier function, and reduce AD severity.	Histidine	40-51	filaggrin	Homo sapiens	109-112
15299314-5	1995	A probe model composed of the backbone atoms of the N-terminal 77 residues of lysine-, arginine-, ornithine-binding protein (LAO, a total of 238 residues) liganded with lysine correctly finds its position on LAO liganded with histidine which crystallizes as a monomer in the asymmetric unit.	Histidine	226-235	interleukin 4 induced 1	Homo sapiens	208-211
32808171-4	2020	To accomplish this, the codon-optimized 1507 bp coding sequence of the human ETS2 gene in fusion with a His-tag, a cell-penetrating peptide, and a nuclear localization sequence was cloned in the protein expression vector and transformed into E. coli strain BL21(DE3) for expression.	Histidine	104-107	ETS proto-oncogene 2, transcription factor	Homo sapiens	77-81
18811882-3	2008	Based chi on the polymorphisms of EPHX1 gene (tyrosine/histidine 113, histidine/arginine 139), the population can be classified into four groups of putative EPHX1 phenotypes (fast, normal, slow and very slow).	Histidine	55-64	epoxide hydrolase 1	Homo sapiens	34-39
7795152-0	1995	Protein C infusion in a patient with inherited protein C deficiency caused by two missense mutations: Arg 178 to Gln and Arg-1 to His.	Histidine	130-133	arginase 1	Homo sapiens	121-126
18811882-3	2008	Based chi on the polymorphisms of EPHX1 gene (tyrosine/histidine 113, histidine/arginine 139), the population can be classified into four groups of putative EPHX1 phenotypes (fast, normal, slow and very slow).	Histidine	70-79	epoxide hydrolase 1	Homo sapiens	34-39
18703510-5	2008	We successfully pulled down histidine-tagged hsp90alpha- and PA28alpha-induced, newly assembled 26 S proteasomes from the cell extracts for in vitro epitope production assay, and we found these structures to be sensitive to geldanamycin, an hsp90 inhibitor.	Histidine	28-37	heat shock protein 90 alpha family class A member 1	Homo sapiens	45-55
18703510-5	2008	We successfully pulled down histidine-tagged hsp90alpha- and PA28alpha-induced, newly assembled 26 S proteasomes from the cell extracts for in vitro epitope production assay, and we found these structures to be sensitive to geldanamycin, an hsp90 inhibitor.	Histidine	28-37	heat shock protein 90 alpha family class A member 1	Homo sapiens	45-50
32973174-0	2020	Author Correction: The protonation state of an evolutionarily conserved histidine modulates domain swapping stability of FoxP1.	Histidine	72-81	forkhead box P1	Homo sapiens	121-126
7831809-4	1995	We now used purified histidine-tagged MxA (His-MxA) that we produced in Escherichia coli to successfully inhibit VSV in vitro transcription, a reaction catalyzed by VSV ribonucleoprotein complexes isolated from virus-infected cells or from purified virions.	Histidine	21-30	MX dynamin like GTPase 1	Homo sapiens	38-41
32559275-3	2020	Although histidine residues on the external side of domain I have been implicated in the effects on Cav2.3 channel gating, the exact mechanisms involved in channel modulation remain incompletely understood.	Histidine	9-18	calcium voltage-gated channel subunit alpha1 E	Homo sapiens	100-106
18768683-6	2008	Of the 23 members of the aspartate-histidine-histidine-cysteine (DHHC) domain containing proteins, DHHC-7 most strongly stimulated palmitoylation of NCAM, and enzyme activity was enhanced by FGF2.	Histidine	35-44	neural cell adhesion molecule 1	Homo sapiens	149-153
7831809-4	1995	We now used purified histidine-tagged MxA (His-MxA) that we produced in Escherichia coli to successfully inhibit VSV in vitro transcription, a reaction catalyzed by VSV ribonucleoprotein complexes isolated from virus-infected cells or from purified virions.	Histidine	21-30	MX dynamin like GTPase 1	Homo sapiens	47-50
18694828-7	2008	A conserved loop and histidine residue in the sequences of OMCI, TSGP2 and TSGP3 are implicated in the interaction with complement C5.	Histidine	21-30	complement C5	Homo sapiens	120-133
32877466-6	2020	Here we produced His-tagged domain 11 (D11), an IGF2-binding element of IGF2R; we immobilized it on the solid support through a well-defined sandwich, consisting of neutravidin, biotin and synthetic anti-His-tag antibodies.	Histidine	17-20	insulin like growth factor 2 receptor	Homo sapiens	48-52
32877466-6	2020	Here we produced His-tagged domain 11 (D11), an IGF2-binding element of IGF2R; we immobilized it on the solid support through a well-defined sandwich, consisting of neutravidin, biotin and synthetic anti-His-tag antibodies.	Histidine	17-20	insulin like growth factor 2 receptor	Homo sapiens	72-77
18676617-3	2008	The Cys- and His-rich repeated N terminus (CH domain) of Upf1 has been implicated in its binding to Upf2.	Histidine	13-16	ATP-dependent RNA helicase NAM7	Saccharomyces cerevisiae S288C	57-61
18676617-7	2008	Substitution of the coordinated Cys and His residues in the CH domain impaired not only self-ubiquitination of Upf1 but also rapid decay of aberrant mRNAs.	Histidine	40-43	ATP-dependent RNA helicase NAM7	Saccharomyces cerevisiae S288C	111-115
7831809-4	1995	We now used purified histidine-tagged MxA (His-MxA) that we produced in Escherichia coli to successfully inhibit VSV in vitro transcription, a reaction catalyzed by VSV ribonucleoprotein complexes isolated from virus-infected cells or from purified virions.	Histidine	43-46	MX dynamin like GTPase 1	Homo sapiens	38-41
7831809-4	1995	We now used purified histidine-tagged MxA (His-MxA) that we produced in Escherichia coli to successfully inhibit VSV in vitro transcription, a reaction catalyzed by VSV ribonucleoprotein complexes isolated from virus-infected cells or from purified virions.	Histidine	43-46	MX dynamin like GTPase 1	Homo sapiens	47-50
7803390-0	1994	Structural consequences of histidine phosphorylation: NMR characterization of the phosphohistidine form of histidine-containing protein from Bacillus subtilis and Escherichia coli.	Histidine	27-36	haptoglobin-related protein	Homo sapiens	107-135
18600814-4	2008	The reactivity achieved with the HJ1 polypeptide, rationally designed to catalyze the hydrolysis of phosphodiesters, is based on two histidine residues flanked by four arginines and two adjacent tyrosine residues, all located on the surface of a helix-loop-helix motif.	Histidine	133-142	jagged canonical Notch ligand 1	Homo sapiens	33-36
18460012-1	2008	Diphthamide is a post-translational derivative of histidine in protein synthesis elongation factor-2 (eEF-2) that is present in all eukaryotes with no known normal physiological role.	Histidine	50-59	eukaryotic translation elongation factor 2	Homo sapiens	81-100
32973811-4	2020	We found that multiple immunizations of HIS-CD8/NKT mice with the nanovaccine resulted in the activation and/or expansion of human CD141+ DCs and iNKT cells and ultimately elicited a potent Melan-A-specific CD8+ T cell response, as determined by tetramer staining and ELISpot assay.	Histidine	40-43	thrombomodulin	Homo sapiens	131-136
32579975-5	2020	Only when PD-1 interacts with PD-L1 did the FSY react with a proximal histidine of PD-L1 selectively, enabling irreversible binding of PD-1 to only PD-L1 in vitro and in vivo.	Histidine	70-79	CD274 molecule	Homo sapiens	30-35
32579975-5	2020	Only when PD-1 interacts with PD-L1 did the FSY react with a proximal histidine of PD-L1 selectively, enabling irreversible binding of PD-1 to only PD-L1 in vitro and in vivo.	Histidine	70-79	CD274 molecule	Homo sapiens	83-88
7534047-0	1994	A mammalian expression vector for the expression of GAL4 fusion proteins with an epitope tag and histidine tail.	Histidine	97-106	galactose-responsive transcription factor GAL4	Saccharomyces cerevisiae S288C	52-56
32328689-3	2020	First, overexpressed DHFR with a His-tag was roughly purified with a Ni-sepharose resin and subjected to native mass spectrometry with or without incubation with an inhibitor, Methotrexate (MTX).	Histidine	33-36	Dihydrofolate reductase	Escherichia coli	21-25
18463094-7	2008	Using liquid chromatography-mass spectroscopy and a VTC2-H238N mutant, we provide evidence that the reaction proceeds through a covalent guanylylated histidine residue within the histidine triad motif.	Histidine	150-159	GDP-L-galactose phosphorylase 1	Arabidopsis thaliana	52-56
18463094-7	2008	Using liquid chromatography-mass spectroscopy and a VTC2-H238N mutant, we provide evidence that the reaction proceeds through a covalent guanylylated histidine residue within the histidine triad motif.	Histidine	179-188	GDP-L-galactose phosphorylase 1	Arabidopsis thaliana	52-56
7534047-6	1994	We describe the construction of two mammalian expression vectors, pMFH/GAL4 and pMFH2/GAL4 (where pMFH stands for pM2, Flag, Histidine tail), which encode the DNA-binding domain of the yeast transcription factor GAL4 with a Flag peptide (consisting of the 11-amino-acid leader peptide of the gene 10 product from bacteriophage T7) at the NH2-terminus and a tail of six histidines at the COOH-terminus.	Histidine	125-134	galactose-responsive transcription factor GAL4	Saccharomyces cerevisiae S288C	86-90
18373493-0	2008	The role of the diphthamide-containing loop within eukaryotic elongation factor 2 in ADP-ribosylation by Pseudomonas aeruginosa exotoxin A. eEF2 (eukaryotic elongation factor 2) contains a post-translationally modified histidine residue, known as diphthamide, which is the specific ADP-ribosylation target of diphtheria toxin, cholix toxin and Pseudomonas aeruginosa exotoxin A. Site-directed mutagenesis was conducted on residues within the diphthamide-containing loop (Leu693-Gly703) of eEF2 by replacement with alanine.	Histidine	219-228	elongation factor 2	Saccharomyces cerevisiae S288C	157-176
7534047-6	1994	We describe the construction of two mammalian expression vectors, pMFH/GAL4 and pMFH2/GAL4 (where pMFH stands for pM2, Flag, Histidine tail), which encode the DNA-binding domain of the yeast transcription factor GAL4 with a Flag peptide (consisting of the 11-amino-acid leader peptide of the gene 10 product from bacteriophage T7) at the NH2-terminus and a tail of six histidines at the COOH-terminus.	Histidine	125-134	galactose-responsive transcription factor GAL4	Saccharomyces cerevisiae S288C	86-90
18465874-8	2008	The presence in PfFKBD of Cys-106 and Ser-109 (substituting for His-87 and Ile-90, respectively, in human FKBP12), which are 4-5 A from the nearest atom of the FK506 compound, suggests possible routes for the rational design of analogues of FK506 with specific antiparasitic activity.	Histidine	64-67	FKBP prolyl isomerase 1A pseudogene 4	Homo sapiens	106-112
32350077-5	2020	Mutational analyses revealed that three histidine residues conserved in the Mpo1 family are especially important for Mpo1 activity, suggesting that they may be responsible for the formation of coordinate bonds with Fe2+ We found that, in addition to activity toward 2-OH long-chain FAs, Mpo1 also exhibits activity toward 2-OH very-long-chain FAs derived from the FA moiety of sphingolipids.	Histidine	40-49	Mpo1p	Saccharomyces cerevisiae S288C	76-80
32350077-5	2020	Mutational analyses revealed that three histidine residues conserved in the Mpo1 family are especially important for Mpo1 activity, suggesting that they may be responsible for the formation of coordinate bonds with Fe2+ We found that, in addition to activity toward 2-OH long-chain FAs, Mpo1 also exhibits activity toward 2-OH very-long-chain FAs derived from the FA moiety of sphingolipids.	Histidine	40-49	Mpo1p	Saccharomyces cerevisiae S288C	117-121
18222027-5	2008	The post-intake of histidine and carnosine significantly decreased MDA formations, increased GSH content, enhanced catalase and GPX activities, and suppressed CYP2E1 activity (P&lt;0.05), in which the effects on catalase and CYP2E1 activities were dose-dependent (P&lt;0.05).	Histidine	19-28	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	159-165
32350077-5	2020	Mutational analyses revealed that three histidine residues conserved in the Mpo1 family are especially important for Mpo1 activity, suggesting that they may be responsible for the formation of coordinate bonds with Fe2+ We found that, in addition to activity toward 2-OH long-chain FAs, Mpo1 also exhibits activity toward 2-OH very-long-chain FAs derived from the FA moiety of sphingolipids.	Histidine	40-49	Mpo1p	Saccharomyces cerevisiae S288C	117-121
7990714-0	1994	Folate-mediated incorporation of ring-2-carbon of histidine into nucleic acids: influence of thyroid hormone.	Histidine	50-59	ring finger protein 2	Homo sapiens	33-39
32279993-2	2020	The specific histidine residues at the extracellular surface of OGR1 are suggested to be involved in the proton sensing.	Histidine	13-22	G protein-coupled receptor 68	Homo sapiens	64-68
18222027-5	2008	The post-intake of histidine and carnosine significantly decreased MDA formations, increased GSH content, enhanced catalase and GPX activities, and suppressed CYP2E1 activity (P&lt;0.05), in which the effects on catalase and CYP2E1 activities were dose-dependent (P&lt;0.05).	Histidine	19-28	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	225-231
18230330-0	2008	Mutational analysis of histidine residues in the human proton-coupled amino acid transporter PAT1.	Histidine	23-32	solute carrier family 36 member 1	Homo sapiens	93-97
18230330-4	2008	Three histidine residues are conserved among the H+-coupled amino acid transporters PAT1 to 4 from different animal species.	Histidine	6-15	solute carrier family 36 member 1	Homo sapiens	84-88
7833918-0	1994	A histidine to tyrosine replacement in lysosomal acid lipase causes cholesteryl ester storage disease.	Histidine	2-11	lipase A, lysosomal acid type	Homo sapiens	39-60
18230330-6	2008	His-55 was found to be essential for the catalytic activity of hPAT1 because the corresponding mutants H55A, H55N and H55E had no detectable l-proline transport activity.	Histidine	0-3	solute carrier family 36 member 1	Homo sapiens	63-68
18230330-9	2008	We conclude that His-55 might be responsible for binding and translocation of H+ in the course of cellular amino acid uptake by PAT1.	Histidine	17-20	solute carrier family 36 member 1	Homo sapiens	128-132
7913895-4	1994	The two essential histidines in the type II copper binding site of APP are conserved in the related protein APLP2.	Histidine	18-28	amyloid beta precursor like protein 2	Homo sapiens	108-113
18203721-0	2008	Deletion of a histidine-rich loop of AtMTP1, a vacuolar Zn(2+)/H(+) antiporter of Arabidopsis thaliana, stimulates the transport activity.	Histidine	14-23	zinc transporter	Arabidopsis thaliana	37-43
18203721-9	2008	We prepared a mutant AtMTP1 that lacked the major part (32 residues from 185 to 216) of a long histidine-rich hydrophilic loop in the central part of AtMTP1.	Histidine	95-104	zinc transporter	Arabidopsis thaliana	21-27
32398349-7	2020	Furthermore, mutation of the conserved His151 abolished the pH dependence of RIPK1 activation, suggesting that this histidine residue functions as a proton acceptor to modulate RIPK1 activity in response to pH changes.	Histidine	116-125	receptor interacting serine/threonine kinase 1	Homo sapiens	77-82
32398349-7	2020	Furthermore, mutation of the conserved His151 abolished the pH dependence of RIPK1 activation, suggesting that this histidine residue functions as a proton acceptor to modulate RIPK1 activity in response to pH changes.	Histidine	116-125	receptor interacting serine/threonine kinase 1	Homo sapiens	177-182
32552204-2	2020	The histidine residue at position 103 is integral to the AHSP hydrogen bond formation where disruption results in an increased quantity of cytotoxic free alpha-globin chains, thereby creating a similar pathophysiology as beta-thalassemia (beta-thal).	Histidine	4-13	alpha hemoglobin stabilizing protein	Homo sapiens	57-61
8034671-6	1994	The carboxyl-terminal sequence His-Asp-Glu-Leu (HDEL) is required for retention of ERC-55 in the ER.	Histidine	31-34	KDEL endoplasmic reticulum protein retention receptor 1	Homo sapiens	48-52
32272966-10	2020	At amino acid level, the strongest association seen in uncontrolled analysis was with histidine at position 114 in HLA-B (P = 7.24 x 10-241), but conditional analyses suggest that the primary amino acid associations are with lysine at position 70 and asparagine at position 97.	Histidine	86-95	major histocompatibility complex, class I, B	Homo sapiens	115-120
18241934-2	2008	In order to develop a rapid and sensitive rotavirus group A LAT, part of segment 6 corresponding to conserved N-terminal portion of the VP6 (1-245 aa) was cloned in Escherichia coli expression pGEX vector (glutathione S-transferase-GST gene fusion system) that has been modified previously containing a histidine tail at C-terminus.	Histidine	303-312	VP6	Rotavirus A	136-139
18194362-2	2008	This allele is identical to the HLA-B*570101 allele except for two point mutations in exon 3 at codon 138 (ACG--&gt;ACC) with no amino acid change [persisting threonine (T)] and at codon 171 (TAC--&gt;CAC), resulting in an amino acid change from tyrosine (Y) to histidine (H).	Histidine	262-271	major histocompatibility complex, class I, B	Homo sapiens	32-37
32328082-7	2020	This strategy was tested successfully by generating a recombinant gene, BiP:p38:bdSUMO : His:hLIF, that produced human leukemia inhibitory factor (hLIF) fused to p38, a coat protein of the Turnip crinkle virus; the inclusion of p38 increased levels of protein expression.	Histidine	89-92	LIF interleukin 6 family cytokine	Homo sapiens	93-97
32328082-7	2020	This strategy was tested successfully by generating a recombinant gene, BiP:p38:bdSUMO : His:hLIF, that produced human leukemia inhibitory factor (hLIF) fused to p38, a coat protein of the Turnip crinkle virus; the inclusion of p38 increased levels of protein expression.	Histidine	89-92	LIF interleukin 6 family cytokine	Homo sapiens	119-145
8034671-6	1994	The carboxyl-terminal sequence His-Asp-Glu-Leu (HDEL) is required for retention of ERC-55 in the ER.	Histidine	31-34	reticulocalbin 2	Homo sapiens	83-89
32328082-7	2020	This strategy was tested successfully by generating a recombinant gene, BiP:p38:bdSUMO : His:hLIF, that produced human leukemia inhibitory factor (hLIF) fused to p38, a coat protein of the Turnip crinkle virus; the inclusion of p38 increased levels of protein expression.	Histidine	89-92	LIF interleukin 6 family cytokine	Homo sapiens	147-151
8007970-7	1994	PPS1 was isolated and shown to be a previously undescribed gene coding for a protein similar in amino acid sequence to phosphoribosylpyrophosphate synthase, a rate-limiting enzyme in the biosynthesis of nucleotides, histidine, and tryptophan.	Histidine	216-225	tyrosine/serine/threonine protein phosphatase PPS1	Saccharomyces cerevisiae S288C	0-4
31841392-3	2020	In cultured mpkCCD cells, administration of recombinant histidine-tagged sPRR (sPRR-His) at 10 nM within minutes induced a significant and transient increase in the amiloride-sensitive short-circuit current as assessed using the Ussing chamber technique.	Histidine	56-65	small proline-rich protein 1A	Rattus norvegicus	73-77
31841392-3	2020	In cultured mpkCCD cells, administration of recombinant histidine-tagged sPRR (sPRR-His) at 10 nM within minutes induced a significant and transient increase in the amiloride-sensitive short-circuit current as assessed using the Ussing chamber technique.	Histidine	56-65	small proline-rich protein 1A	Rattus norvegicus	79-83
18177055-5	2008	First, variants of RAP-D3 resistant to low pH-induced unfolding were constructed by replacing interior histidine residues with phenylalanines.	Histidine	103-112	LDL receptor related protein associated protein 1	Homo sapiens	19-25
18227430-4	2008	To investigate whether this serine addition is assisted by the catalytic His-Asp dyad, we generated two mutants of DPP-IV, S630A and H740Q, and assayed them for ability to bind inhibitor.	Histidine	73-76	dipeptidyl peptidase 4	Homo sapiens	115-121
7920705-8	1994	A modified SUC1-His6 cDNA encoding a histidine tag at the SUC1 C-terminus was also expressed in S. cerevisiae.	Histidine	37-46	1-(5-phosphoribosyl)-5- ((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase HIS6	Saccharomyces cerevisiae S288C	16-20
18203258-4	2008	Site-specific, dose-dependent modification of Cys47 in native and His-tagged GSTP was revealed by MS, and correlated with inhibition of glutathione (GSH) conjugating activity.	Histidine	66-69	glutathione S-transferase pi 1	Homo sapiens	77-81
31820933-4	2020	The histidine residues contained in these fragments are potential binding sites for metal ions and are located close to the regions that drive the formation of amyloid aggregates of tau.	Histidine	4-13	microtubule associated protein tau	Homo sapiens	182-185
8204590-0	1994	Replacement of the proximal ligand of sperm whale myoglobin with free imidazole in the mutant His-93--&gt;Gly.	Histidine	94-97	myoglobin	Physeter catodon	50-59
31276825-10	2020	However, this may be specific for human IDO1 because G9th/His was demonstrated to be very effective in increasing the L-Trp affinity even in vertebrate IDOs.	Histidine	58-61	indoleamine 2,3-dioxygenase 1	Homo sapiens	40-44
17956868-8	2007	Replacing Pro-40 of UGT1A4 by histidine expanded the glucuronidation activity of the enzyme to phenolic and carboxylic compounds, therefore, leading to UGT1A3-type isoform in terms of substrate specificity.	Histidine	30-39	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	20-26
17956868-9	2007	Conversely, when His-40 residue of UGT1A3 was replaced with proline, the substrate specificity shifted toward that of UGT1A4 with loss of glucuronidation of phenolic substrates.	Histidine	17-20	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	118-124
17956868-10	2007	Furthermore, mutation of His-39 residue of UGT1A1 (His-40 in UGT1A4) to proline led to loss of glucuronidation of phenols but not of estrogens.	Histidine	25-28	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	61-67
17956868-10	2007	Furthermore, mutation of His-39 residue of UGT1A1 (His-40 in UGT1A4) to proline led to loss of glucuronidation of phenols but not of estrogens.	Histidine	51-54	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	61-67
8158118-1	1994	A histidine residue (His394) that is likely to be located in the ligand-binding region of the D2 dopamine receptor has been mutated to a leucine (Leu394), and the properties of the mutant receptor have been determined.	Histidine	2-11	dopamine receptor D2	Homo sapiens	94-114
17939663-2	2007	In the complex formed between morphinone reductase (MR) and the NADH analogue 1,4,5,6-tetrahydro-NADH (NADH4) the nicotinamide moiety is restrained close to the FMN isoalloxazine ring by hydrogen bonds from Asn-189 and His-186 as determined from the X-ray crystal structure.	Histidine	219-222	formin 1	Homo sapiens	161-164
17620335-5	2007	The epitope for 4B6.13 anti-TSP-2 was localized to His-722 and Leu-703 in repeat 1C of the wire; recognition only occurred in constructs that included EGF3, the rest of the wire, and the lectin-like module and in the presence of calcium.	Histidine	51-54	thrombospondin 2	Homo sapiens	28-33
32943150-2	2020	Over the past few years, our group has explored several strategies to modulate the carbene transfer reactivity of myoglobin-based catalysts, including the substitution of the native heme cofactor and conserved histidine axial ligand with non-native porphynoid ligands and alternative natural and unnatural amino acids as the metal-coordinating ligands, respectively.	Histidine	210-219	myoglobin	Homo sapiens	114-123
31401272-4	2019	We have observed that while the migration of acidic bovine serum albumin (BSA) was independent of the buffer concentration, the behavior of basic lysozyme was greatly improved at higher buffer concentration, e.g., 100 mM histidine-100 mM MES.	Histidine	221-230	albumin	Bos taurus	59-72
8013745-3	1994	The role of histidine on the decarboxylation of porphyrinogens of 7-, 6-, and 5-COOH III brought about by porphyrinogen carboxy-lyase (PCL) was studied.	Histidine	12-21	uroporphyrinogen decarboxylase	Rattus norvegicus	106-133
31639017-2	2019	The common features of MCPIP proteins are the zinc finger domain, consisting of three cysteines and one histidine (CCCH), and the N-terminal domain of the PilT protein (PilT-N-terminal domain (PIN domain)).	Histidine	104-113	zinc finger CCCH-type containing 12A	Homo sapiens	23-28
31351182-6	2019	Furthermore, one residue located at 10 A distance from the catalytic site is different between the sub-families but highly conserved within each sub-family (Asp in AOC1, His in AOC2, Thr in AOC3 and Asn in AOC4) and likely contributes to substrate selectivity.	Histidine	170-173	amine oxidase copper containing 2	Homo sapiens	177-181
17763374-5	2007	Docking analysis indicated that the binding to D(2) and 5-HT(1A) receptors is based on (i) interaction between protonated N1 of the piperazine ring and various aspartate residues, (ii) hydrogen bonds between various moieties of the ligand and the residues of threonine, serine, histidine or tryptophane, and (iii) edge-to-face interactions of the aromatic ring of the arylpiperazine moiety with phenylalanine or tyrosine residues.	Histidine	278-287	5-hydroxytryptamine receptor 1A	Homo sapiens	56-63
8013745-3	1994	The role of histidine on the decarboxylation of porphyrinogens of 7-, 6-, and 5-COOH III brought about by porphyrinogen carboxy-lyase (PCL) was studied.	Histidine	12-21	uroporphyrinogen decarboxylase	Rattus norvegicus	135-138
8144593-0	1994	Role of histidine 35 of the S1 subunit of pertussis toxin in the ADP-ribosylation of transducin.	Histidine	8-17	retinoschisin 1	Rattus norvegicus	28-30
17565994-10	2007	The results of kinetic studies of site-directed mutants of GmIF7GT showed that both His-15 and Asp-125, which correspond to the catalytic residues of UGT71G1 and VvGT1, are not important for GmIF7GT activity.	Histidine	84-87	isoflavone 7-O-glucosyltransferase 1	Glycine max	59-66
17567580-6	2007	On the basis of structural analysis, along with site-directed mutagenesis, a mechanism for the enzyme is proposed in which a decarboxylation reaction occurs directly, and the invariant histidine residue in the OHCU decarboxylase family plays an essential role in producing (S)-allantoin through a proton transfer from the hydroxyl group at C4 to C5 at the re-face of OHCU.	Histidine	185-194	ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase	Homo sapiens	210-228
31078062-2	2019	To do this, multiwalled carbon nanotube (MWCNT)/L-histidine functionalized reduced graphene oxide (His-rGO) was demonstrated as a bifunctional nanoplatform for covalently attaching thionine redox indicator and anti-PSA antibody (Ab).	Histidine	50-59	kallikrein related peptidase 3	Homo sapiens	215-218
31078062-2	2019	To do this, multiwalled carbon nanotube (MWCNT)/L-histidine functionalized reduced graphene oxide (His-rGO) was demonstrated as a bifunctional nanoplatform for covalently attaching thionine redox indicator and anti-PSA antibody (Ab).	Histidine	99-102	kallikrein related peptidase 3	Homo sapiens	215-218
31150637-3	2019	Positively charged arginine (R) and histidine (H) of mouse AQP0 ELA and ELC were substituted individually with glutamine (Q) to create R33Q, H40Q, R113Q and H122Q by mutagenesis.	Histidine	36-45	apelin receptor early endogenous ligand	Mus musculus	64-67
17526865-4	2007	In the passive smoking group, there was a remarkable decrease in birth weight with the C/C6235 genotype (156.3 g, 95% confidence interval (CI): -283.6, -29.0) for CYP1A1 MspI and with Tyr/His113 (93.8 g, 95% CI: -188.6, -1.1) as compared with His/His113 (244.6 g, 95% CI: -491.0, -1.9) for EPHX1.	Histidine	188-191	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	163-169
8144593-1	1994	Molecular modeling of the S1 subunit (S1) of pertussis toxin with other ADP-ribosylating bacterial exotoxins predicted that histidine 35 (His-35) would residue within the active site of S1.	Histidine	124-133	retinoschisin 1	Rattus norvegicus	26-28
17526865-5	2007	When results were stratified by maternal genotype, passive smoking conferred a significantly negative effect in the EPHX1 Tyr/His113 group (103.5 g, 95% CI: -205.8, -9.2) and in the His/His113 group (687.3 g, 95% CI: -748.3, -178.3).	Histidine	126-129	epoxide hydrolase 1	Homo sapiens	116-121
8144593-1	1994	Molecular modeling of the S1 subunit (S1) of pertussis toxin with other ADP-ribosylating bacterial exotoxins predicted that histidine 35 (His-35) would residue within the active site of S1.	Histidine	124-133	retinoschisin 1	Rattus norvegicus	38-40
31082440-6	2019	15N NMR spectra indicate that removal of the second histidine converted the protonation and tautomeric equilibria of H19 to be similar to the H37 behavior in AM2, indicating that the peripheral H27 is indeed the origin of the low pKa"s of H19 in wild-type BM2.	Histidine	52-61	H19 imprinted maternally expressed transcript	Homo sapiens	117-120
31082440-6	2019	15N NMR spectra indicate that removal of the second histidine converted the protonation and tautomeric equilibria of H19 to be similar to the H37 behavior in AM2, indicating that the peripheral H27 is indeed the origin of the low pKa"s of H19 in wild-type BM2.	Histidine	52-61	adrenomedullin 2	Homo sapiens	158-161
31082440-6	2019	15N NMR spectra indicate that removal of the second histidine converted the protonation and tautomeric equilibria of H19 to be similar to the H37 behavior in AM2, indicating that the peripheral H27 is indeed the origin of the low pKa"s of H19 in wild-type BM2.	Histidine	52-61	H19 imprinted maternally expressed transcript	Homo sapiens	239-242
8144593-1	1994	Molecular modeling of the S1 subunit (S1) of pertussis toxin with other ADP-ribosylating bacterial exotoxins predicted that histidine 35 (His-35) would residue within the active site of S1.	Histidine	124-133	retinoschisin 1	Rattus norvegicus	38-40
17670971-3	2007	Here, we demonstrate that reducing agents as well as endogenous metal chelators sensitize C-type dorsal root ganglion nociceptors by chelating Zn2+ ions off specific extracellular histidine residues on Ca(v)3.2 T-channels, thus relieving tonic channel inhibition, enhancing Ca(v)3.2 currents, and lowering the threshold for nociceptor excitability in vitro and in vivo.	Histidine	180-189	immunoglobulin lambda variable 7-43	Homo sapiens	202-210
8144593-1	1994	Molecular modeling of the S1 subunit (S1) of pertussis toxin with other ADP-ribosylating bacterial exotoxins predicted that histidine 35 (His-35) would residue within the active site of S1.	Histidine	138-141	retinoschisin 1	Rattus norvegicus	26-28
17670971-3	2007	Here, we demonstrate that reducing agents as well as endogenous metal chelators sensitize C-type dorsal root ganglion nociceptors by chelating Zn2+ ions off specific extracellular histidine residues on Ca(v)3.2 T-channels, thus relieving tonic channel inhibition, enhancing Ca(v)3.2 currents, and lowering the threshold for nociceptor excitability in vitro and in vivo.	Histidine	180-189	immunoglobulin lambda variable 7-43	Homo sapiens	274-282
8144593-1	1994	Molecular modeling of the S1 subunit (S1) of pertussis toxin with other ADP-ribosylating bacterial exotoxins predicted that histidine 35 (His-35) would residue within the active site of S1.	Histidine	138-141	retinoschisin 1	Rattus norvegicus	38-40
8144593-1	1994	Molecular modeling of the S1 subunit (S1) of pertussis toxin with other ADP-ribosylating bacterial exotoxins predicted that histidine 35 (His-35) would residue within the active site of S1.	Histidine	138-141	retinoschisin 1	Rattus norvegicus	38-40
17567089-1	2007	A series of myoglobin mutants, in which distal sites are modified by site-directed mutagenesis, are able to catalyze peroxidase, catalase, and P450 reactions even though their proximal histidine ligands are intact.	Histidine	185-194	myoglobin	Homo sapiens	12-21
7510762-4	1994	Complexes of human HLA-DR2 (DRB1*1501/DRB5*0101) and a peptide analog from human myelin basic protein MBP(84-102) containing a 6 histidine tag (6 x His) and a tyrosine residue at the N-terminus end [6 x His-MBP(83-102)Y83] were prepared and purified.	Histidine	129-138	myelin basic protein	Homo sapiens	102-105
31222087-6	2019	DTA exerts its toxic activity through inhibition of eukaryotic translation elongation factor 2 (eEF2) via adenosine diphosphate (ADP)-ribosylation of a modified histidine residue, diphthamide, at His715, which blocks protein translation and leads to cell death.	Histidine	161-170	eukaryotic translation elongation factor 2	Homo sapiens	52-94
31222087-6	2019	DTA exerts its toxic activity through inhibition of eukaryotic translation elongation factor 2 (eEF2) via adenosine diphosphate (ADP)-ribosylation of a modified histidine residue, diphthamide, at His715, which blocks protein translation and leads to cell death.	Histidine	161-170	eukaryotic translation elongation factor 2	Homo sapiens	96-100
7510762-4	1994	Complexes of human HLA-DR2 (DRB1*1501/DRB5*0101) and a peptide analog from human myelin basic protein MBP(84-102) containing a 6 histidine tag (6 x His) and a tyrosine residue at the N-terminus end [6 x His-MBP(83-102)Y83] were prepared and purified.	Histidine	148-151	myelin basic protein	Homo sapiens	81-101
7510762-4	1994	Complexes of human HLA-DR2 (DRB1*1501/DRB5*0101) and a peptide analog from human myelin basic protein MBP(84-102) containing a 6 histidine tag (6 x His) and a tyrosine residue at the N-terminus end [6 x His-MBP(83-102)Y83] were prepared and purified.	Histidine	203-206	myelin basic protein	Homo sapiens	102-105
17479226-6	2007	The results demonstrated that 4 x Ala, 4 x His, 4 x Gln, and 4 x Cys produced over 200% of the yield of wild-type GST.	Histidine	43-46	glutathione S-transferase kappa 1	Homo sapiens	114-117
7510762-7	1994	The quantitation of bound peptide in the eluted complexes showed 100% occupancy of HLA-DR2 (DRB1*1501/DRB5*0101) with [6 x His-MBP(83-102)Y83] peptide with a recovery of 50-75%.	Histidine	123-126	myelin basic protein	Homo sapiens	127-130
7510762-10	1994	Finally, we demonstrate that both MBP(84-102) and [6 x His-MBP(83-102)Y83] peptides were equally capable of stimulating restricted T cell line in the presence of autologous antigen presenting cells (APCs).	Histidine	55-58	myelin basic protein	Homo sapiens	59-62
8194740-8	1994	In some experiments, the PRL isoforms, PRLI and PRLII, could be separately measured and their release appeared to be differentially affected by TRH and cyclo(His-Pro).	Histidine	158-161	prolactin	Oncorhynchus mykiss	25-28
17503777-8	2007	Sco1, a distantly related thioredoxin-fold protein, has histidine in place of the cis-proline, and this residue binds copper.	Histidine	56-65	thioredoxin	Homo sapiens	26-37
31182777-0	2019	Insight into the structural stability of wild-type and histidine mutants in Pin1 by experimental and computational methods.	Histidine	55-64	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	76-80
8152420-4	1994	In the presence of heme, it binds through a cysteine-rich domain in which a histidine residue occupies the position of the sixth and essential cysteine of the otherwise classical zinc cluster DNA-binding domain exemplified by GAL4.	Histidine	76-85	galactose-responsive transcription factor GAL4	Saccharomyces cerevisiae S288C	226-230
30453113-4	2019	Here, we analysis the structural effects of 4-HNE modification through formation of Michael adducts of Cys-4HNE, His-4HNE and Lys-4HNE on Serum Albumin (BSA) and Thioredoxin (TRX).	Histidine	113-116	thioredoxin	Homo sapiens	162-173
30251657-7	2018	NMR data demonstrate that the recombinant domains of THB2 and THB4 coordinate the ferrous heme iron with the proximal histidine and a lysine from the distal helix.	Histidine	118-127	uncharacterized protein	Chlamydomonas reinhardtii	53-57
17542813-4	2007	When expressed in X-ALD fibroblasts lacking ALDP, the expression level of mutant His-ALDPs (S606L, R617H, and H667D) was lower than that of wild type and other mutant ALDPs.	Histidine	81-84	ATP binding cassette subfamily D member 1	Homo sapiens	44-48
17542813-9	2007	In addition, mutant His-ALDP (Y174C), which has a mutation between transmembrane domain 2 and 3, did not exhibit peroxisomal localization by immunofluorescense study.	Histidine	20-23	ATP binding cassette subfamily D member 1	Homo sapiens	24-28
8159788-6	1994	Escherichia coli produced histidine-tagged A.t.Rab6 protein-bound GTP, whereas a mutation in one of the guanine nucleotide-binding sites (asparagine122 to isoleucine) rendered it incapable of binding GTP.	Histidine	26-35	Ras-related small GTP-binding family protein	Arabidopsis thaliana	47-51
17593742-3	2007	Studies on protein sequences and on synthesized peptides revealed that a histidine-containing sequence had specific interactions with precious metal ions (Au3+ and Pd2+).	Histidine	73-82	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	164-167
30187100-6	2018	A large amount of the small P particles and the trimer and dimer complexes formed by 12, 6, and 2 P monomers were observed in both the expression of the NoV P-His and P containing cysteine tag at the N-terminus.	Histidine	159-162	plexin A1	Homo sapiens	153-158
30187100-7	2018	Dynamic light scattering and transmission electron microscopy analysis of the purified NoV P-His and P revealed that most of these small P particles are triangle-, square-, and ring-shaped with a diameter of 14-15 nm.	Histidine	93-96	plexin A1	Homo sapiens	87-92
30207701-6	2018	Comparison of the nuCO and nuFe-C values of the heme-DNA complexes with those of myoglobin (Mb) revealed that the donor strength of the axial ligation trans to the CO in a complex is considerably weaker than that of the proximal histidine in Mb, as expected from the coordination of H2O trans to the CO in the complex.	Histidine	229-238	myoglobin	Homo sapiens	81-90
17084858-7	2007	Antibodies 3F1 through 3F4, which are similar to our previously identified 3A6 class of antibodies, catalyze hydrolysis through transition state stabilization by tyrosine or histidine residues H50 and L94.	Histidine	174-183	histocompatibility 50	Mus musculus	193-196
8300566-0	1994	Identification of oxidized histidine generated at the active site of Cu,Zn-superoxide dismutase exposed to H2O2.	Histidine	27-36	superoxide dismutase [Cu-Zn]	Bos taurus	69-95
17098236-2	2007	The medaka ppTRH cDNA codes for 270 amino acid residues including eight TRH progenitor sequences (-Lys/Arg-Arg-Gln-His-Pro-Gly-Lys/Arg-Arg-).	Histidine	115-118	thyrotropin-releasing hormone	Oryzias latipes	11-16
17584126-3	2007	Our initial efforts in this area have focused on affinity and selectivity directed optimization of the native beta-MSH(5-22) sequence and resulted in the discovery of a potent MC4R agonist: Ac-Tyr-Arg-[Cys-Glu-His-D-Phe-Arg-Trp-Cys]-NH(2) (10).	Histidine	210-213	melanocortin 4 receptor	Mus musculus	176-180
17143275-0	2007	HLA-DM targets the hydrogen bond between the histidine at position beta81 and peptide to dissociate HLA-DR-peptide complexes.	Histidine	45-54	major histocompatibility complex, class II, DM alpha	Homo sapiens	0-6
29991592-4	2018	We identified a highly conserved, 13-residue segment (ADP-1) from adiponectin"s collagen domain, which comprises GXXG motifs and has one asparagine and two histidine residues that assist in oligomeric protein assembly.	Histidine	156-165	adiponectin, C1Q and collagen domain containing	Mus musculus	66-77
8300566-5	1994	Here we report on the identification of oxidized histidines generated at the active site of Cu,Zn-SOD by reaction with H2O2.	Histidine	49-59	superoxide dismutase [Cu-Zn]	Bos taurus	92-101
30138320-6	2018	Therefore, three experimental positives were used in addition to the negative control (Flg-his).	Histidine	91-94	filaggrin	Homo sapiens	87-90
16997281-2	2006	In this study we produced, and expressed in Xenopus oocytes, individual alanine point mutants of positively charged amino acids (eight lysine, seven arginine and one histidine) in the intracellular domains of the human P2X1 receptor.	Histidine	166-175	purinergic receptor P2X 1	Homo sapiens	219-232
8300566-6	1994	When bovine erythrocyte Cu,Zn-SOD (0.5 mg/ml) was treated with 5 mM H2O2 in 50 mM sodium phosphate buffer (pH 7.2), histidine was significantly lost; however, except for a significant increase in aspartate and glutamate, nothing new appeared in the amino acid analysis of oxidized Cu,Zn-SOD.	Histidine	116-125	superoxide dismutase [Cu-Zn]	Bos taurus	24-33
8300566-12	1994	Trypsin digestion of H2O2-treated Cu,Zn-SOD showed selective reactions at the sequences of Gly24-Lys67 and Thr114-Arg126, in that histidine residues locate at the active center.	Histidine	130-139	superoxide dismutase [Cu-Zn]	Bos taurus	34-43
8300566-16	1994	Taken together, the present study provided direct evidence that 2-oxo-histidine was generated in the Cu,Zn-SOD exposed to H2O2 and that its generation was selective at histidine 118 of the active site of the enzyme.	Histidine	70-79	superoxide dismutase [Cu-Zn]	Bos taurus	101-110
8188630-4	1994	We concluded that the His residue at position 261 is essential for the ligation of the Zn of cabbage HDH.	Histidine	22-25	histidinol dehydrogenase, chloroplastic	Brassica oleracea	101-104
16901896-4	2006	The SNAP50 zinc finger domain contains 15 cysteine and histidine residues configured in two potential zinc coordination arrangements.	Histidine	55-64	small nuclear RNA activating complex polypeptide 3	Homo sapiens	4-10
30123127-5	2018	Histidine residue acts as general base thus leading to attacking water molecule activation and subsequent SN2 inline hydrolysis resulting in BChE reactivation.	Histidine	0-9	butyrylcholinesterase	Homo sapiens	141-145
8245015-2	1993	Nm23 was previously demonstrated to exhibit nucleoside diphosphate kinase (NDPK) activity, which transfers a phosphate among nucleoside tri- and diphosphates via an Nm23-phospho-histidine intermediate.	Histidine	178-187	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	0-4
29897749-5	2018	Here we show that Trp binding to the Si site or the mutation of S167 to histidine in hIDO1 retards its turnover activity and that the inhibited activity can be rescued by an effector, 3-indole ethanol (IDE).	Histidine	72-81	indoleamine 2,3-dioxygenase 1	Homo sapiens	85-90
16977317-6	2006	Modeling with F-actin predicts that the length of this WH2-containing arm is critical for severing function, and the addition of a single amino acid (alanine or histidine) eliminates CapG-sev severing activity, confirming this prediction.	Histidine	161-170	capping actin protein, gelsolin like	Homo sapiens	183-187
8245015-2	1993	Nm23 was previously demonstrated to exhibit nucleoside diphosphate kinase (NDPK) activity, which transfers a phosphate among nucleoside tri- and diphosphates via an Nm23-phospho-histidine intermediate.	Histidine	178-187	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	165-169
29696512-7	2018	Expression of PI3K-Akt-mTOR/JNK (24 h after HI or OGD/R) proteins was detected by Western blotting after stimulation with HI, NGR1, LY294002 (PI3K inhibitor), 740Y-P (PI3K agonist), or ICI 182780(estrogen receptors inhibitor).	Histidine	44-46	mitogen-activated protein kinase 8	Rattus norvegicus	28-31
16844077-0	2006	Histidine residues in the region between transmembrane domains III and IV of hZip1 are required for zinc transport across the plasma membrane in PC-3 cells.	Histidine	0-9	solute carrier family 39 member 1	Homo sapiens	77-82
8366106-2	1993	A cysteine-rich motif identified the COP1 protein as a member of a group of regulatory proteins which share the amino acid motif Cys-X-X-Cys-loop I-Cys-X-His-X-X-Cys-X-X-Cys-loop II-Cys-X-X-Cys (ring finger).	Histidine	154-157	Transducin/WD40 repeat-like superfamily protein	Arabidopsis thaliana	37-41
16945939-6	2006	Although this configuration is similar to those of other beta-lactamases, TTHA0252 has one conserved His residue characteristic of the beta-CASP family as a ligand.	Histidine	101-104	MBL fold metallo-hydrolase	Thermus thermophilus HB8	74-82
29849110-3	2018	In this research we report a FRalpha binding peptide C7(Met-His-Thr-Ala-Pro-Gly-Trp-Gly-Tyr-Arg-Leu-Ser) discovered by phage display and this peptide showed specific binding to FRalpha expressing cells by cell ELISA and flow cytometry.	Histidine	60-63	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	29-36
8370708-2	1993	In healthy humans, the synthetic peptide GH-releasing peptide (GHRP) (His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) releases GH by a putative mechanism of action that is independent of GHRH.	Histidine	70-73	growth hormone secretagogue receptor	Homo sapiens	41-61
16967187-8	2006	All these findings suggested that the fused expressed His-DR inhibited the activity of natural DDR2, and relevant MMP-1 and MMP-2 expression in synoviocytes and NIH3T3 cells provoked by collagen II.	Histidine	54-57	discoidin domain receptor family, member 2	Mus musculus	95-99
29624837-0	2018	Two Histidines in an alpha-Helix: A Rigid Co2+ -Binding Motif for PCS Measurements by NMR Spectroscopy.	Histidine	4-14	complement C2	Homo sapiens	42-45
29624837-3	2018	We show that two histidine residues in sequential turns of an alpha-helix provide a binding site for a Co2+ ion, which positions the metal ion in a uniquely well-defined and predictable location.	Histidine	17-26	complement C2	Homo sapiens	103-106
16842804-0	2006	Adsorptive refolding of histidine-tagged glutathione S-transferase using metal affinity chromatography.	Histidine	24-33	glutathione S-transferase kappa 1	Homo sapiens	41-66
8370708-2	1993	In healthy humans, the synthetic peptide GH-releasing peptide (GHRP) (His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) releases GH by a putative mechanism of action that is independent of GHRH.	Histidine	70-73	growth hormone secretagogue receptor	Homo sapiens	63-67
8336737-7	1993	Analysis of mRNAs produced from the ADE4, ADE5,7, ADE8, and ADE1 genes indicates that GCN4 stimulates the expression of these genes under conditions of histidine starvation, and it appeared that ADE8 mRNA was also derepressed by GCN4 in purine-starved cells.	Histidine	152-161	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	86-90
16310386-5	2006	Primary (Val(87), Phe(90)) and secondary (Asn(92), Ile(93), Thr(95)) MHC anchors occupy the same region in space, whereas T-cell receptor (TCR) contacts (His(88), Phe(89)) have different orientation between the two structures.	Histidine	154-157	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	122-137
16310386-5	2006	Primary (Val(87), Phe(90)) and secondary (Asn(92), Ile(93), Thr(95)) MHC anchors occupy the same region in space, whereas T-cell receptor (TCR) contacts (His(88), Phe(89)) have different orientation between the two structures.	Histidine	154-157	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	139-142
8321192-8	1993	Within the NFKB1 portion of this fusion protein, a single amino acid change of His to Arg altered the DNA-binding specificity to favor interaction with the RelA-selective DNA motif.	Histidine	79-82	RELA proto-oncogene, NF-kB subunit	Homo sapiens	156-160
29688719-2	2018	We demonstrate herein that the photoactive platinum(IV) anticancer complex trans,trans,trans-[Pt(N3)2(OH)2(Py)2] (1) can bind to His, Glu, and Gln residues of Trx upon the irradiation of blue light.	Histidine	129-132	thioredoxin	Homo sapiens	159-162
8100523-7	1993	When human serum was incubated with GIP or GLP-1(7-36)amide the same fragments as with the purified dipeptidyl-peptidase IV, namely the des-Xaa-Ala peptides and Tyr-Ala in the case of GIP or His-Ala in the case of GLP-1(7-36)amide, were identified as the main degradation products of these peptide hormones.	Histidine	191-194	glucagon like peptide 1 receptor	Homo sapiens	43-48
29698455-6	2018	Mitochondria are tagged by insertion of 6 histidines (6xHis) into the TOM70 (Translocase of outer membrane 70) gene at its chromosomal locus, isolated using Ni-NTA (nickel (II) nitrilotriacetic acid) paramagnetic beads and released from the magnetic beads by washing with imidazole.	Histidine	42-52	protein channel TOM70	Saccharomyces cerevisiae S288C	70-75
16815950-0	2006	The hpa1 mutant of Arabidopsis reveals a crucial role of histidine homeostasis in root meristem maintenance.	Histidine	57-66	histidinol phosphate aminotransferase 1	Arabidopsis thaliana	4-8
16815950-5	2006	Biochemical analysis shows that the mutation in hpa1 only resulted in a 30% reduction in free His content and had no significant impact on the total His content.	Histidine	94-97	histidinol phosphate aminotransferase 1	Arabidopsis thaliana	48-52
16815950-8	2006	We have demonstrated that the root meristem failure in the mutant is tightly linked to the reduction in free His content and could be rescued by either exogenous His supplementation or AtHPA1 overexpression.	Histidine	109-112	histidinol phosphate aminotransferase 1	Arabidopsis thaliana	185-191
8357536-7	1993	The histidines beta 2 and beta 143 of the two beta-chains form hydrogen bonds with the phosphates.	Histidine	4-14	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	15-21
16563127-12	2006	Expression of His-C/EBPbeta-P4 in HepG2 cells significantly diminishes the OM-induced increase in LDLR promoter activity and the elevation of endogenous LDLR mRNA expression.	Histidine	14-17	low density lipoprotein receptor	Homo sapiens	98-102
16563127-12	2006	Expression of His-C/EBPbeta-P4 in HepG2 cells significantly diminishes the OM-induced increase in LDLR promoter activity and the elevation of endogenous LDLR mRNA expression.	Histidine	14-17	low density lipoprotein receptor	Homo sapiens	153-157
16636053-6	2006	Mutations of His/Cys residues in the HCCH motif impair zinc coordination, Cul5 binding, and APOBEC3G degradation.	Histidine	13-16	cullin 5	Homo sapiens	74-78
29287303-6	2018	Recombinant His-tagged full-length DEK protein (1-375 amino acids [aa]) and the 187-375-aa and 1-350-aa His-tagged DEK fragments made in a baculovirus system were used for enzyme-linked immunosorbent assay (ELISA) and immunoblotting.	Histidine	12-15	DEK proto-oncogene	Homo sapiens	35-38
29590114-6	2018	The c.2510G&gt;A transition variant is predicted to substitute a highly invariant arginine residue with histidine (p.Arg837His) in the phosphatase domain of PPIP5K2.	Histidine	104-113	diphosphoinositol pentakisphosphate kinase 2	Mus musculus	157-164
8504086-0	1993	Solution structure determination of the heme cavity in the E7 His--&gt;Val cyano-met myoglobin point mutant based on the 1H NMR detected dipolar field of the iron: evidence for contraction of the heme pocket.	Histidine	62-65	myoglobin	Physeter catodon	85-94
29547723-5	2018	Direct metal binding to a histidine-rich stretch in IRT1 triggers its phosphorylation by the CIPK23 kinase and facilitates the subsequent recruitment of the IDF1 E3 ligase.	Histidine	26-35	allograft inflammatory factor 1	Homo sapiens	52-56
16597698-9	2006	GUP1 function depends on the active site histidine of the MBOAT motif.	Histidine	41-50	O-acyltransferase	Saccharomyces cerevisiae S288C	0-4
8427859-0	1993	Glutamine/histidine polymorphism in apo A-IV affects plasma concentrations of lipoprotein(a) and fibrin split products in coronary heart disease patients.	Histidine	10-19	lipoprotein(a)	Homo sapiens	78-92
8427859-1	1993	A glutamine/histidine polymorphism at residue 360 in apolipoprotein (apo) A-IV that generates two electrophoretically detectable isoforms, apo A-IV-1 and apo A-IV-2, affects the plasma concentration of lipoprotein(a) (Lp[a]) in a healthy population.	Histidine	12-21	lipoprotein(a)	Homo sapiens	202-216
8419357-0	1993	The roles of His-64, Tyr-103, Tyr-146, and Tyr-151 in the epoxidation of styrene and beta-methylstyrene by recombinant sperm whale myoglobin.	Histidine	13-16	myoglobin	Physeter catodon	131-140
16625026-4	2006	We show here that Thg1 is &gt;10,000-fold more selective for its cognate substrate tRNA(His) than for the noncognate substrate tRNA(Phe).	Histidine	88-91	tRNA guanylyltransferase	Saccharomyces cerevisiae S288C	18-22
29134764-0	2018	Peptides derived from histidine and methionine-rich regions of copper transporter 1 exhibit anti-angiogenic property by chelating extracellular Cu.	Histidine	22-31	solute carrier family 31 member 1	Homo sapiens	63-83
29134764-6	2018	In this study, we have designed three peptides from copper-binding regions of CTR1 which are rich in histidine and methionine.	Histidine	101-110	solute carrier family 31 member 1	Homo sapiens	78-82
8474224-1	1993	Monoclonal antibodies (TB1 & TB2), which were obtained by immunization of 24 amino acids in BALB/c mice, bound specifically to the amyloid senile plaque and amyloid-angiopathic lesions of brain tissues of patients with Alzheimer"s disease (AD) or with senile dementia of Alzheimer type (SDAT), and strongly reacted with the 1st part (Asp-Ala-Glu-Phe-Arg-His-Asp) of beta-protein.	Histidine	354-357	trophoblast specific protein alpha	Mus musculus	23-26
16690078-7	2006	Therefore the Fab fragment of 9F8 was cloned and recombinant 9F8 Fab (rFab) was purified from E. coli periplasmic fraction using a C-terminal His tag.	Histidine	142-145	FA complementation group B	Homo sapiens	65-68
1472066-6	1992	PTHrP 1-139 lacks the carboxy-terminal arginine and histidine residues of PTHrP 1-141; these two basic amino acids could have significant effects on the biological activity of PTHrP.	Histidine	52-61	parathyroid hormone like hormone	Homo sapiens	0-5
16554024-1	2006	A half-type ABC transporter, human TAP-like (hTAPL) tagged with histidine cluster, was expressed in budding yeast protease-deficient strain BJ5457, and the effect of expression for resistance to peptide compounds including antibiotics and proteinase inhibitor was examined.	Histidine	64-73	ATP binding cassette subfamily B member 9	Homo sapiens	45-50
16537570-9	2006	Surprisingly, cells expressing torsinA with the polymorphic histidine developed inclusions similar to those associated with DeltaGAG-torsinA, indicating that this change may also affect torsinA structure.	Histidine	60-69	torsin family 1 member A	Homo sapiens	31-38
1472066-6	1992	PTHrP 1-139 lacks the carboxy-terminal arginine and histidine residues of PTHrP 1-141; these two basic amino acids could have significant effects on the biological activity of PTHrP.	Histidine	52-61	parathyroid hormone like hormone	Homo sapiens	74-79
1472066-6	1992	PTHrP 1-139 lacks the carboxy-terminal arginine and histidine residues of PTHrP 1-141; these two basic amino acids could have significant effects on the biological activity of PTHrP.	Histidine	52-61	parathyroid hormone like hormone	Homo sapiens	74-79
1448929-5	1992	These results suggest that nsP2 is a papain-like proteinase whose catalytic dyad is composed of Cys-481 and His-558.	Histidine	108-111	reticulon 2	Homo sapiens	27-31
16432504-7	2006	Chiral alpha-branched analogues exhibited a marked stereoselectivity at the H3R and H4R, the enantiomers with a configuration equivalent to L-histidine being preferred at both receptors.	Histidine	140-151	histamine receptor H3	Homo sapiens	76-79
16432504-7	2006	Chiral alpha-branched analogues exhibited a marked stereoselectivity at the H3R and H4R, the enantiomers with a configuration equivalent to L-histidine being preferred at both receptors.	Histidine	140-151	histamine receptor H4	Homo sapiens	84-87
16595957-1	2006	A two-step binding assay for globotriaosylceramide (Gb3) content was developed by histidine-tagging strategy, which is a well-established method for the purification of recombinant proteins.	Histidine	82-91	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	52-55
16595957-2	2006	The complete binding of the recombinant His-tagged Shiga toxin 1B subunit (1B-His) (1 microg/ml) to the standard Gb3 adsorbed on a multi-well H type plate was observed within 30 min at 37 degrees C; and its binding could be visualized by the following applications of HisProbe-HRP (8 microg/ml) and tetramethylbenzidine (TMB) peroxidase substrate.	Histidine	40-43	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	113-116
1487235-1	1992	The formation of histamine from its precursor histidine is catalyzed by histidine decarboxylase (HDC), a pyridoxal phosphate (PLP)-dependent decarboxylase.	Histidine	46-55	histidine decarboxylase	Rattus norvegicus	72-95
16415340-2	2006	Here, we demonstrate that the DNA-binding domain of Spt10p is located between residues 283 and 396 and includes a His(2)-Cys(2) zinc finger.	Histidine	114-117	Spt10p	Saccharomyces cerevisiae S288C	52-58
1487235-1	1992	The formation of histamine from its precursor histidine is catalyzed by histidine decarboxylase (HDC), a pyridoxal phosphate (PLP)-dependent decarboxylase.	Histidine	46-55	histidine decarboxylase	Rattus norvegicus	97-100
1379588-4	1992	We have identified, however, three FKBP12 surface residues (Asp-37, Arg-42, and His-87) proximal to a solvent-exposed segment of bound FK506 that may be direct contacts in the calcineurin complex.	Histidine	80-83	FKBP prolyl isomerase 1A pseudogene 2	Homo sapiens	35-41
16278015-2	2006	In this study, an oligohistidine (His(6)) epitope tag was incorporated at the N-terminus of an ELP using recombinant DNA techniques to permit tracking without compromising on material biocompatibility.	Histidine	34-37	nuclear receptor subfamily 5 group A member 1	Homo sapiens	95-98
1592884-1	1992	Intravenous infusions of the synthetic hexapeptide GH-releasing peptide (His-DTrp-Ala-Trp-DPhe-Lys-NH2; GHRP) specifically stimulate GH release in man.	Histidine	73-76	growth hormone secretagogue receptor	Homo sapiens	104-108
16637264-8	2006	Theoretical possibility of copper transfer from His-Cys-His CTR1 C-terminal motif to cytosolic Cys-X-X-Cys Cu(I) chaperon sites has been shown.	Histidine	48-51	solute carrier family 31 member 1	Homo sapiens	60-64
16637264-8	2006	Theoretical possibility of copper transfer from His-Cys-His CTR1 C-terminal motif to cytosolic Cys-X-X-Cys Cu(I) chaperon sites has been shown.	Histidine	56-59	solute carrier family 31 member 1	Homo sapiens	60-64
1314325-1	1992	Thyroliberin E-H-P-NH2 (TRH) is a small neuropeptide pGlu-His-Pro-NH2 widely distributed in neural sites.	Histidine	58-61	thyrotropin releasing hormone	Rattus norvegicus	24-27
16377633-7	2006	These findings indicate that His-191 in the S3-S4 loop is a critical residue conferring nickel block to Ca(v)3.2 and reveal a novel role for the S3-S4 loop to control ion permeation through T-type Ca2+ channels.	Histidine	29-32	immunoglobulin lambda variable 7-43	Homo sapiens	104-112
1421205-0	1992	Effects of dexamethasone on TRH and TRH precursor peptide (Lys-Arg-Gln-His-Pro-Gly-Arg-Arg) levels in various rat organs.	Histidine	71-74	thyrotropin releasing hormone	Rattus norvegicus	36-39
16395674-2	2006	In knockout mice mismatch-repair (MMR) defects or inactivation of the fragile histidine triad (FHIT) gene are associated with MTS-like signs, including SGC.	Histidine	78-87	serglycin	Mus musculus	152-155
1421205-1	1992	The effect of an acute dexamethasone administration on thyrotropin-releasing hormone (TRH) and TRH precursor peptide (Lys-Arg-Gln-His-Pro-Gly-Arg-Arg) (p-8) levels in various rat organs has been studied.	Histidine	130-133	thyrotropin releasing hormone	Rattus norvegicus	95-98
1551461-0	1992	Involvement of histidine residues in catalytic activity of xanthine dehydrogenase from hen liver.	Histidine	15-24	xanthine dehydrogenase	Homo sapiens	59-81
16293613-11	2006	His-216 occupies a position similar to that of Tyr-136 in bovine rhodopsin, part of the DRY motif of the latter receptor.	Histidine	0-3	rhodopsin	Bos taurus	65-74
21204476-14	2006	Erf2p and Akr1p are integral membrane proteins harboring a cysteine-rich domain containing a conserved DHHC (Asp-His-His-Cys) motif.	Histidine	113-116	palmitoyltransferase ERF2	Saccharomyces cerevisiae S288C	0-5
1551461-2	1992	Modification of histidine residue(s) of xanthine dehydrogenase from hen liver by DEP and photooxidation results in loss of the ability to transfer electrons from xanthine to NAD+ and also from NADH to 2,6-dichlorophenolindophenol (DCIP).	Histidine	16-25	xanthine dehydrogenase	Homo sapiens	40-62
1540654-7	1992	The transition observed for loss of alpha-helix coincides with the previously measured transition for His-12 by NMR from a partially folded state to the unfolded state, suggesting that the unfolding of the N-terminal helix in RNase A is lost after unfolding of the core beta-sheet during thermal denaturation.	Histidine	102-105	ribonuclease A family member 1, pancreatic	Homo sapiens	226-233
16320010-0	2006	Insights into the role of the histidines in the structure and stability of cytochrome c.	Histidine	30-40	cytochrome c, somatic	Equus caballus	75-87
1413735-11	1992	Modification of the enzyme by EDC or DEPC led to complete loss of activity, which suggests that carboxyl group(s) and histidine residue(s) are essential for activity of alpha-glucosidase.	Histidine	118-127	TTH_RS10165	Thermus thermophilus HB8	169-186
16320010-1	2006	In this paper we investigate the role played by each histidine in the amino acid sequence of yeast iso-1-cytochrome c (with the exception of H18, the residue axially coordinated to the heme iron) in determining the protein structure and stability.	Histidine	53-62	cytochrome c, somatic	Equus caballus	105-117
16328052-4	2006	rHAUSP cDNA encodes 3,312 bp and 1,103 amino acids with a molecular weight of approximately 135 kDa containing highly conserved Cys, Asp (I), His, and Asn/Asp (II) domains characteristic of the ubiquitin-specific processing proteases.	Histidine	142-145	ubiquitin specific peptidase 7	Rattus norvegicus	0-6
16246823-2	2005	We replaced Ser71 in Mc b5 with Leu, with the prediction that it would retard heme loss by diminishing polypeptide expansion accompanying rupture of the histidine to iron bonds.	Histidine	153-162	cytochrome b5 type A	Homo sapiens	21-26
16314460-6	2005	Thus, in U4 atac snRNA we identified His 270 in the spliceosomal U4/U6 snRNP-specific protein 61 K (hPrp31p) cross-linked to U 44; in the U1 snRNP we show that Leu175 of the U1 snRNP-specific 70K protein is cross-linked to U 30 of U1 snRNA.	Histidine	37-40	RNA binding region (RNP1, RRM) containing 3	Homo sapiens	174-182
1414511-5	1992	As demonstrated in experiments with an inhibitor of histidine decarboxylase--semicarbazide, this effect comprised 15% inhibition evoked by the histamine precursor--histidine, whereas the remaining 60% inhibition could be ascribed to the effect of newly synthesized histamine.	Histidine	162-173	histidine decarboxylase	Rattus norvegicus	52-75
1659529-0	1991	Evidence for a role of protein kinase-C in His-D-Trp-Ala-Trp-D-Phe-Lys-NH2-induced growth hormone release from rat primary pituitary cells.	Histidine	43-46	gonadotropin releasing hormone receptor	Rattus norvegicus	83-97
16285720-7	2005	Remarkable similarities between the results obtained in this study and those reported previously for the related Cbl-dependent isomerase methylmalonyl-CoA mutase indicate that a common mechanism by which the cofactor"s Co-C bond is activated for homolytic cleavage may be operative for all base-off/His-on Cbl-dependent isomerases.	Histidine	299-302	Cbl proto-oncogene	Homo sapiens	113-116
16285720-7	2005	Remarkable similarities between the results obtained in this study and those reported previously for the related Cbl-dependent isomerase methylmalonyl-CoA mutase indicate that a common mechanism by which the cofactor"s Co-C bond is activated for homolytic cleavage may be operative for all base-off/His-on Cbl-dependent isomerases.	Histidine	299-302	Cbl proto-oncogene	Homo sapiens	306-309
1659529-1	1991	We have recently reported that His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 (GHRP-6) synergizes with GH-releasing factor (GRF) to increase GH release and cAMP accumulation in rat pituitary cells in vitro.	Histidine	31-34	growth hormone releasing hormone	Rattus norvegicus	109-112
1799213-7	1991	The endotoxins adsorbed on immobilized histidine are directly reacted with the LAL reagent in a filter cup and show enough activity for assay.	Histidine	39-48	lipase A, lysosomal acid type	Homo sapiens	79-82
16274251-5	2005	Interestingly, a histidine outside the central polyproline motif contributes significantly to Lck SH3 binding affinity and specificity.	Histidine	17-26	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	94-97
1799213-9	1991	The new endotoxin assay method using immobilized histidine can be utilized for the determination of endotoxins in a solution containing LAL-inhibiting or -enhancing substances such as amino acids and antibiotics instead of requiring employment of the more common gel-clot technique.	Histidine	49-58	lipase A, lysosomal acid type	Homo sapiens	136-139
1919003-2	1991	Comparison of amino acid sequences of the alpha-chain fragment of C4, C4d, has shown C4A- and C4B-specific sequences at residues 1101-1106 are the only consistent structural difference between isotype, i.e., Pro, Cys, Pro, Val, Leu, Asp in C4A and Leu, Ser, Pro, Val Ile, His in C4B.	Histidine	272-275	complement C4B (Chido blood group)	Homo sapiens	94-97
16154994-9	2005	In the current study, we show that the conserved His-460 is a key active site residue for hACAT1.	Histidine	49-52	acetyl-CoA acetyltransferase 1	Homo sapiens	90-96
16292933-4	2005	The role of the proximal histidine is, in particular, clearly demonstrated in the first step of the myoglobin relaxation from its liganded to it deliganded form.	Histidine	25-34	myoglobin	Homo sapiens	100-109
1918039-0	1991	Modification of histidine 56 in adrenodoxin with diethyl pyrocarbonate inhibited the interaction with cytochrome P-450scc and adrenodoxin reductase.	Histidine	16-25	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	102-121
16141206-0	2005	Two conserved histidine residues are critical to the function of the TagF-like family of enzymes.	Histidine	14-23	CDP-glycerol:polyglycerol phosphate glycero-phosphotransferase (poly(glycerol phosphate) polymerase)	Bacillus subtilis subsp. subtilis str. 168	69-73
1680393-0	1991	Involvement of the carboxy-terminal residue in the active site of the histidine-containing protein, HPr, of the phosphoenolpyruvate:sugar phosphotransferase system of Escherichia coli.	Histidine	70-79	haptoglobin-related protein	Homo sapiens	100-103
16141206-5	2005	Alteration of histidine residues 474 and 612 by site-directed mutagenesis abolished TagF activity in vitro (5000-fold reduction in k(cat)/K(m)) while variants in four other conserved acidic residues showed minimal loss of activity.	Histidine	14-23	CDP-glycerol:polyglycerol phosphate glycero-phosphotransferase (poly(glycerol phosphate) polymerase)	Bacillus subtilis subsp. subtilis str. 168	84-88
1680393-1	1991	Histidine-containing protein, HPr, of the Escherichia coli phosphoenolpyruvate:sugar phosphotransferase system has an active site that involves His-15, which is phosphorylated to form a N delta 1-P-histidine, Arg-17, and the carboxy-terminal residue Glu-85.	Histidine	0-9	haptoglobin-related protein	Homo sapiens	30-33
1680393-1	1991	Histidine-containing protein, HPr, of the Escherichia coli phosphoenolpyruvate:sugar phosphotransferase system has an active site that involves His-15, which is phosphorylated to form a N delta 1-P-histidine, Arg-17, and the carboxy-terminal residue Glu-85.	Histidine	0-3	haptoglobin-related protein	Homo sapiens	30-33
16061414-0	2005	Catalytic mechanism of S-adenosylhomocysteine hydrolase: roles of His 54, Asp130, Glu155, Lys185, and Aspl89.	Histidine	66-69	adenosylhomocysteinase	Homo sapiens	23-55
1805795-2	1991	The azotization at histidine and or tyrosine of GnRH was carried out and characterized extensively.	Histidine	19-28	gonadotropin releasing hormone 1	Homo sapiens	48-52
16195551-1	2005	Human peripheral-type cannabinoid receptor (CB2) was expressed in Escherichia coli as a fusion with the maltose-binding protein, thioredoxin, and a deca-histidine tag.	Histidine	153-162	cannabinoid receptor 2	Homo sapiens	44-47
1898367-5	1991	The protein sequence of G7a contains two short consensus sequences, His-Ile-Gly-His and Lys-Met-Ser-Lys-Ser, which is the typical signature structure of class I tRNA synthetases and indicative of the presence of the Rossman fold.	Histidine	68-71	valyl-tRNA synthetase 1	Homo sapiens	24-27
1898367-5	1991	The protein sequence of G7a contains two short consensus sequences, His-Ile-Gly-His and Lys-Met-Ser-Lys-Ser, which is the typical signature structure of class I tRNA synthetases and indicative of the presence of the Rossman fold.	Histidine	80-83	valyl-tRNA synthetase 1	Homo sapiens	24-27
16511155-1	2005	Imidazoleglycerol-phosphate dehydratase catalyses the sixth step of the histidine-biosynthesis pathway in plants and microorganisms and has been identified as a possible target for the development of novel herbicides.	Histidine	72-81	imidazoleglycerol-phosphate dehydratase	Arabidopsis thaliana	0-39
1717598-7	1991	This was further substantiated by the observation that MON-101 and MON-102 specifically recognized a conjugate between bovine serum albumin and the synthetic peptide Phe-Glu-Pro-Glu-His-Asp-Tyr-Pro-Gly-Leu-Gly-Lys based upon the deduced amino acid sequence of the predicted epitope region in 7B2.	Histidine	182-185	secretogranin V	Rattus norvegicus	292-295
15843493-2	2005	SLC38A3 is a sodium-coupled neutral amino acid transporter having substrate preference for l-glutamate, l-histidine, and l-alanine.	Histidine	104-115	solute carrier family 38, member 3	Mus musculus	0-7
15905212-3	2005	Swapping the divergent histidine (H107) residue in GlyR alpha1, which together with the conserved H109 forms part of an intersubunit Zn2+-binding site, for the equivalent asparagine residue present in GlyR alpha2 and alpha3, reversed this phenotype.	Histidine	23-32	glycine receptor alpha 1	Homo sapiens	51-62
1889406-3	1991	Protamine HP4 contains high amounts of arginine, cysteine and histidine.	Histidine	62-71	defensin alpha 4	Homo sapiens	10-13
15908428-1	2005	Herein, we report the heterologous expression of the human peroxisomal 63-kDa calcium-independent phospholipase A2gamma (iPLA2gamma) isoform in Sf9 cells, purification of the N-terminal His-tagged enzyme by affinity chromatography, and the identification of its remarkable substrate selectivity that results in the highly selective generation of 2-arachidonoyl lysophosphatidylcholine.	Histidine	186-189	patatin like phospholipase domain containing 8	Homo sapiens	78-119
15908428-1	2005	Herein, we report the heterologous expression of the human peroxisomal 63-kDa calcium-independent phospholipase A2gamma (iPLA2gamma) isoform in Sf9 cells, purification of the N-terminal His-tagged enzyme by affinity chromatography, and the identification of its remarkable substrate selectivity that results in the highly selective generation of 2-arachidonoyl lysophosphatidylcholine.	Histidine	186-189	patatin like phospholipase domain containing 8	Homo sapiens	121-131
1856262-1	1991	GH-releasing peptide (GHRP; His-D-Trp-Ala-Trp-D-Phe-Lys-NH2), a hexapeptide derived from enkephalin, has been shown to have GH-releasing activity in man and several animal species.	Histidine	28-31	growth hormone secretagogue receptor	Homo sapiens	0-20
16176092-10	2005	This suggested that pET-His-beta3/BL21(DE3)plysS was a suitable expression system for beta3, and the expressed beta3 specially inhibited the adhesion of cancer cells.	Histidine	24-27	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	28-33
16176092-10	2005	This suggested that pET-His-beta3/BL21(DE3)plysS was a suitable expression system for beta3, and the expressed beta3 specially inhibited the adhesion of cancer cells.	Histidine	24-27	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	86-91
16176092-10	2005	This suggested that pET-His-beta3/BL21(DE3)plysS was a suitable expression system for beta3, and the expressed beta3 specially inhibited the adhesion of cancer cells.	Histidine	24-27	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	86-91
1856262-1	1991	GH-releasing peptide (GHRP; His-D-Trp-Ala-Trp-D-Phe-Lys-NH2), a hexapeptide derived from enkephalin, has been shown to have GH-releasing activity in man and several animal species.	Histidine	28-31	growth hormone secretagogue receptor	Homo sapiens	22-26
2064618-7	1991	This residue (His-680) probably represents the active-site histidine of prolyl endopeptidase.	Histidine	14-17	prolyl endopeptidase	Homo sapiens	72-92
16008726-5	2005	Furthermore, serum deprivation-induced apoptosis in a keloid fibroblast line was blocked by a caspase-9 inhibitor (acetyl-Leu-Glu-His-Asp-al), indicating that activation of caspase-9 was necessary for the process of apoptosis in keloid fibroblasts.	Histidine	130-133	caspase 9	Homo sapiens	94-103
16008726-5	2005	Furthermore, serum deprivation-induced apoptosis in a keloid fibroblast line was blocked by a caspase-9 inhibitor (acetyl-Leu-Glu-His-Asp-al), indicating that activation of caspase-9 was necessary for the process of apoptosis in keloid fibroblasts.	Histidine	130-133	caspase 9	Homo sapiens	173-182
2064618-7	1991	This residue (His-680) probably represents the active-site histidine of prolyl endopeptidase.	Histidine	59-68	prolyl endopeptidase	Homo sapiens	72-92
2017175-3	1991	Fusions of the yeast ribosomal protein genes RPL16A, CRY1, RPS16A, and RPL25 with the Escherichia coli lacZ gene were used to show that the expression of these genes is reduced by a factor of 2 to 5 during histidine-limited exponential growth and that this regulation occurs at the level of transcription.	Histidine	206-215	ribosomal 60S subunit protein L25	Saccharomyces cerevisiae S288C	71-76
15952772-5	2005	Using the microdialysis ATR-FTIR setup, we determined that a histidine and the carboxylate group of a glutamate are involved in Zn(2+) binding.	Histidine	61-70	ATR serine/threonine kinase	Equus caballus	24-27
2017175-7	1991	Yeast strains bearing a mutation in any one of the genes GCN1 to GCN4 are defective in derepression of amino acid biosynthetic genes in 10 different pathways under conditions of histidine limitation.	Histidine	178-187	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	65-69
2014261-2	1991	Competition experiments followed by mutational analysis show that the epitope on hGH for hPRL receptor consists of strong determinants in the middle of helix 1 (comprising residues His-18, His-21, and Phe-25), a loop region (including Ile-58, Ser-62, and Asn-63), and the central portion of helix 4 (containing residues Arg-167, Lys-168, Lys-172, Glu-174, Phe-176, and Arg-178).	Histidine	181-184	prolactin receptor	Homo sapiens	89-102
15744050-6	2005	Finally, we revisit the histidine auxotrophy of ade3 or ade16 ade17 mutants.	Histidine	24-33	trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase ADE3	Saccharomyces cerevisiae S288C	48-52
15744050-7	2005	Interestingly, overexpression of PMU1, encoding a potential phosphomutase, partially suppresses the histidine requirement of an ade3 ade16 ade17 triple mutant, most probably by reducing the level of AICAR in this mutant.	Histidine	100-109	trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase ADE3	Saccharomyces cerevisiae S288C	128-132
29399652-5	2018	In this study, we determine the effect of N-terminal His-tags on the thermal stability of select proteins using differential scanning fluorimetry and identify that the removal of the His-tag can have both beneficial and deleterious effects on their stability.	Histidine	53-56	long intergenic non-protein coding RNA 1194	Homo sapiens	57-60
29399652-5	2018	In this study, we determine the effect of N-terminal His-tags on the thermal stability of select proteins using differential scanning fluorimetry and identify that the removal of the His-tag can have both beneficial and deleterious effects on their stability.	Histidine	183-186	long intergenic non-protein coding RNA 1194	Homo sapiens	57-60
2014261-2	1991	Competition experiments followed by mutational analysis show that the epitope on hGH for hPRL receptor consists of strong determinants in the middle of helix 1 (comprising residues His-18, His-21, and Phe-25), a loop region (including Ile-58, Ser-62, and Asn-63), and the central portion of helix 4 (containing residues Arg-167, Lys-168, Lys-172, Glu-174, Phe-176, and Arg-178).	Histidine	189-192	prolactin receptor	Homo sapiens	89-102
16849170-3	2005	His-26 and His-33 are both solvent exposed, and the results suggest that one of these histidine residues acts as a bridge in the electron transfer to and from the haem iron of cytochrome c.	Histidine	0-3	cytochrome c, somatic	Equus caballus	176-188
2014261-4	1991	Three of these side chains (His-18, His-21, and Glu-174) are ligands for binding Zn2+, which is required for high-affinity hGH-hPRL receptor complex formation.	Histidine	28-31	prolactin receptor	Homo sapiens	127-140
16849170-3	2005	His-26 and His-33 are both solvent exposed, and the results suggest that one of these histidine residues acts as a bridge in the electron transfer to and from the haem iron of cytochrome c.	Histidine	11-14	cytochrome c, somatic	Equus caballus	176-188
16849170-3	2005	His-26 and His-33 are both solvent exposed, and the results suggest that one of these histidine residues acts as a bridge in the electron transfer to and from the haem iron of cytochrome c.	Histidine	86-95	cytochrome c, somatic	Equus caballus	176-188
15713471-8	2005	Addition of an 11 amino acid residue extension to the C terminus of P(6) also produced a dimer, whereas the P(6) labelled with a His-tag at the N terminus displayed a monomer structure.	Histidine	129-132	exosome component 9	Homo sapiens	108-112
29387685-3	2017	The Hsp90-mediated activation of NLR receptors (Nucleotide-binding domain and Leucine-rich Repeat) in the innate immunity of both plants and animals is dependent on the co-chaperone Sgt1 and in plants on Rar1, a cysteine- and histidine-rich domain (CHORD)-containing protein.	Histidine	226-235	heat shock protein 90 alpha family class A member 1	Homo sapiens	4-9
2014261-4	1991	Three of these side chains (His-18, His-21, and Glu-174) are ligands for binding Zn2+, which is required for high-affinity hGH-hPRL receptor complex formation.	Histidine	36-39	prolactin receptor	Homo sapiens	127-140
15735016-1	2005	We used gene targeting in mice to insert a His(6)-tagged mouse c-Myc cDNA, Myc(His), head to head into the mouse immunoglobulin heavy-chain locus, Igh, just 5" of the intronic enhancer, Emu.	Histidine	43-46	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	65-68
2015894-1	1991	The conversion of histidine to histamine by histidine decarboxylase (HDC) is of central importance in the control of vertebrate acid secretion.	Histidine	18-27	histidine decarboxylase	Rattus norvegicus	44-67
2015894-1	1991	The conversion of histidine to histamine by histidine decarboxylase (HDC) is of central importance in the control of vertebrate acid secretion.	Histidine	18-27	histidine decarboxylase	Rattus norvegicus	69-72
1676519-2	1991	Multiple sequence alignments for CAT and LAT have highlighted two conserved motifs that contain the active-site histidine and serine residues of CAT.	Histidine	112-121	chloramphenicol acetyltransferase	Escherichia coli	33-36
15697300-6	2005	The thioredoxin is a recombinant form of the natural globular protein with a histidine patch (His-patch-thioredoxin) and is zwitterionic.	Histidine	77-86	thioredoxin	Homo sapiens	4-15
15697300-6	2005	The thioredoxin is a recombinant form of the natural globular protein with a histidine patch (His-patch-thioredoxin) and is zwitterionic.	Histidine	77-86	thioredoxin	Homo sapiens	104-115
15697300-6	2005	The thioredoxin is a recombinant form of the natural globular protein with a histidine patch (His-patch-thioredoxin) and is zwitterionic.	Histidine	94-97	thioredoxin	Homo sapiens	4-15
15697300-6	2005	The thioredoxin is a recombinant form of the natural globular protein with a histidine patch (His-patch-thioredoxin) and is zwitterionic.	Histidine	94-97	thioredoxin	Homo sapiens	104-115
28624997-4	2018	The CYP55B1 protein was characterized spectrally and purified by a HIS-trap column.	Histidine	67-70	uncharacterized protein	Chlamydomonas reinhardtii	4-11
1676519-2	1991	Multiple sequence alignments for CAT and LAT have highlighted two conserved motifs that contain the active-site histidine and serine residues of CAT.	Histidine	112-121	chloramphenicol acetyltransferase	Escherichia coli	145-148
29218639-3	2018	In this work, we examine two of such His-rich regions from forkhead box and MAFA proteins-MB3 (contains 18 His) and MB6 (with 21 His residues), focusing on the affinity and binding modes of Cu2+ and Zn2+ towards the two His-rich regions.	Histidine	37-40	MAF bZIP transcription factor A	Homo sapiens	76-80
29218639-3	2018	In this work, we examine two of such His-rich regions from forkhead box and MAFA proteins-MB3 (contains 18 His) and MB6 (with 21 His residues), focusing on the affinity and binding modes of Cu2+ and Zn2+ towards the two His-rich regions.	Histidine	107-110	MAF bZIP transcription factor A	Homo sapiens	76-80
15661533-4	2005	OVCA1 appears to be the homolog of yeast DPH2, which participates in the first biosynthetic step of diphthamide, by modification of histidine on translation elongation factor 2 (EF-2).	Histidine	132-141	2-(3-amino-3-carboxypropyl)histidine synthase	Saccharomyces cerevisiae S288C	41-45
29218639-3	2018	In this work, we examine two of such His-rich regions from forkhead box and MAFA proteins-MB3 (contains 18 His) and MB6 (with 21 His residues), focusing on the affinity and binding modes of Cu2+ and Zn2+ towards the two His-rich regions.	Histidine	107-110	MAF bZIP transcription factor A	Homo sapiens	76-80
1826349-5	1991	Several lines of evidence indicate that the zinc finger-like structure is essential for the binding of protein C to U1 snRNP particles: i) deletion analysis of protein C showed that the N-terminal 45 amino acids are sufficient for binding to U1 snRNPs, ii) modification of the cysteine residues in the N-terminal domain with N-ethylmaleimide and iii) single point mutations of the cysteines and histidines contributing to the putative zinc finger abolished binding of protein C to U1 snRNPs.	Histidine	395-405	RNA, U1 small nuclear 1	Homo sapiens	116-124
29218639-3	2018	In this work, we examine two of such His-rich regions from forkhead box and MAFA proteins-MB3 (contains 18 His) and MB6 (with 21 His residues), focusing on the affinity and binding modes of Cu2+ and Zn2+ towards the two His-rich regions.	Histidine	107-110	MAF bZIP transcription factor A	Homo sapiens	76-80
29027595-1	2018	Carnosinase (CN1) is a dipeptidase, encoded by the CNDP1 gene, that degrades histidine-containing dipeptides, such as carnosine, anserine and homocarnosine.	Histidine	77-86	carnosine dipeptidase 1	Homo sapiens	13-16
15724202-1	2005	The electron transfer reaction of wild-type myoglobin at an electrode was significantly facilitated in a D2O buffer as compared with that in an H2O buffer, with k(0)"(H2O)/k(0)"(D2O)= 0.13, while a minimal deuterium kinetic isotope effect on the myoglobin with modification at distal histidine (His-64) was observed.	Histidine	284-293	myoglobin	Homo sapiens	44-53
29027595-1	2018	Carnosinase (CN1) is a dipeptidase, encoded by the CNDP1 gene, that degrades histidine-containing dipeptides, such as carnosine, anserine and homocarnosine.	Histidine	77-86	carnosine dipeptidase 1	Homo sapiens	51-56
1847591-2	1991	A series of VIP analogues, including pituitary adenylate cyclase-activating polypeptide (PACAP), displaced 125I-VIP binding and activated adenylate cyclase in the same order of relative potency: PACAP-38 greater than helodermin greater than VIP, PACAP-27 greater than PHM (human peptide with NH2-terminal histidine and COOH-terminal methionine amide).	Histidine	305-314	adenylate cyclase activating polypeptide 1	Homo sapiens	37-87
15659125-0	2005	Pharmacokinetics of His-tag recombinant human endostatin in Rhesus monkeys.	Histidine	20-23	collagen type XVIII alpha 1 chain	Homo sapiens	46-56
15659125-1	2005	AIM: To study the pharmacokinetics and accumulation of an Escherichia coli expressed His-tag fused recombinant human endostatin (rh-endostatin) in Rhesus monkeys.	Histidine	85-88	collagen type XVIII alpha 1 chain	Homo sapiens	117-127
15659125-1	2005	AIM: To study the pharmacokinetics and accumulation of an Escherichia coli expressed His-tag fused recombinant human endostatin (rh-endostatin) in Rhesus monkeys.	Histidine	85-88	collagen type XVIII alpha 1 chain	Homo sapiens	132-142
30097101-5	2018	Radical SAM enzymes in diphthamide biosynthesis cleave a different CS bond in SAM to generate a 3-amino-3-carboxypropyl radical and modify a histidine residue of substrate protein EF2.	Histidine	141-150	eukaryotic translation elongation factor 2	Homo sapiens	180-183
1847591-2	1991	A series of VIP analogues, including pituitary adenylate cyclase-activating polypeptide (PACAP), displaced 125I-VIP binding and activated adenylate cyclase in the same order of relative potency: PACAP-38 greater than helodermin greater than VIP, PACAP-27 greater than PHM (human peptide with NH2-terminal histidine and COOH-terminal methionine amide).	Histidine	305-314	adenylate cyclase activating polypeptide 1	Homo sapiens	89-94
15671563-1	2005	PURPOSE: The novel fusion protein, DAB389EGF, composed of the catalytic and translocation domains of diphtheria toxin (DAB389) fused with a His-Ala linker to human epidermal growth factor (EGF) was tested for antiglioma efficacy in an in vivo model of human glioma.	Histidine	140-143	epidermal growth factor	Homo sapiens	164-187
15671563-1	2005	PURPOSE: The novel fusion protein, DAB389EGF, composed of the catalytic and translocation domains of diphtheria toxin (DAB389) fused with a His-Ala linker to human epidermal growth factor (EGF) was tested for antiglioma efficacy in an in vivo model of human glioma.	Histidine	140-143	epidermal growth factor	Homo sapiens	41-44
1899022-0	1991	Substitution of histidine-84 and the GTPase mechanism of elongation factor Tu.	Histidine	16-25	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	57-77
15508143-12	2005	Further sequence analysis revealed total conservation of ATCUN histidines in four proteins including the transcription factor TBX3, implicated in Ulnar-Mammary Syndrome.	Histidine	63-73	T-box transcription factor 3	Homo sapiens	126-130
28987271-7	2017	For Kv11.1 channels (hERG1) the extracellularly accessible histidines H578 and H587 are CORM-2 targets.	Histidine	59-69	potassium voltage-gated channel subfamily H member 2	Homo sapiens	4-10
28987271-7	2017	For Kv11.1 channels (hERG1) the extracellularly accessible histidines H578 and H587 are CORM-2 targets.	Histidine	59-69	potassium voltage-gated channel subfamily H member 2	Homo sapiens	21-26
1723945-3	1990	The canine shaking pup carries such a mutation, a single base change that substitutes a proline for a histidine near the first transmembrane region of PLP and DM-20.	Histidine	102-111	proteolipid protein 1	Canis lupus familiaris	151-154
28987271-8	2017	The strong CO-independent action of CORM-2 on Kv11.1 and Kv1.5 channels can be completely abolished when CORM-2 is applied in the presence of an excess of free histidine or human serum albumin; cysteine and methionine are further potential targets.	Histidine	160-169	potassium voltage-gated channel subfamily H member 2	Homo sapiens	46-52
15489893-2	2004	The ST18 gene encodes a zinc-finger DNA-binding protein with six fingers of the C2HC type (configuration Cys-X5-Cys-X12-His-X4-Cys) and an SMC domain.	Histidine	120-123	ST18 C2H2C-type zinc finger transcription factor	Homo sapiens	4-8
2198287-7	1990	The residue His-391 in the recombinant inner-core domain (E2b delta 167) was changed to Asn or Gln by site-directed mutagenesis.	Histidine	12-15	dihydrolipoamide branched chain transacylase E2	Bos taurus	58-61
15476823-2	2004	The site of interaction of the tumor suppressor p53 and the oncoprotein E1A with CBP/p300 has been identified with the third cysteine-histidine-rich (CH3) domain, which incorporates two zinc-binding motifs, ZZ and TAZ2.	Histidine	134-143	transformation related protein 53, pseudogene	Mus musculus	48-51
15304516-8	2004	Classical pathway regulation, both through decay acceleration and factor I cleavage of C4b, required a cluster of positively charged amino acids in CCP1 stretching into CCP2 (Arg-20, Arg-33, Arg-35, Lys-64, Lys-65, and Lys-88) as well as positively (Lys-131, Lys-133, and His-135) and negatively (Glu-99, Glu-152, and Asp-155) charged areas at opposing faces of the border region between CCPs 2 and 3.	Histidine	272-275	coiled-coil domain containing 115	Homo sapiens	148-152
28991911-7	2017	Some haplotypes of IgG3 have histidine at position 435.	Histidine	29-38	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	19-23
29042806-4	2017	In mammalian skin, l-histidine is rapidly incorporated into filaggrin.	Histidine	19-30	filaggrin	Homo sapiens	60-69
2103453-3	1990	The sequence around a conserved histidine residue in a putative membrane-spanning region of the polypeptide resembles sequences present in cytochrome b from chromaffin granules and neutrophil membranes, suggesting that the open reading frame may encode a haem-binding polypeptide, possibly a b-type cytochrome.	Histidine	32-41	cytochrome b	Nicotiana tabacum	139-151
29042806-5	2017	Subsequent filaggrin proteolysis releases l-histidine as an important natural moisturizing factor (NMF).	Histidine	42-53	filaggrin	Homo sapiens	11-20
29042806-6	2017	In vitro studies were conducted to investigate the influence of l-histidine on filaggrin processing and barrier function in human skin-equivalent models.	Histidine	64-75	filaggrin	Homo sapiens	79-88
29042806-9	2017	In vitro studies demonstrated that l-histidine significantly increased both filaggrin formation and skin barrier function (P&lt;0.01, respectively).	Histidine	35-46	filaggrin	Homo sapiens	76-85
29042806-12	2017	The clinical effect of oral l-histidine in AD was similar to that of mid-potency topical corticosteroids and combined with its safety profile suggests that it may be a safe, nonsteroidal approach suitable for long-term use in skin conditions that are associated with filaggrin deficits such as AD.	Histidine	28-39	filaggrin	Homo sapiens	267-276
15454439-9	2004	Mutation of an extracellular histidine residue, H508, that mediates the inhibitory effect of protons on Kv1.4 current, abolished both K+ activation and the enhancement of K+ activation at acidic pH.	Histidine	29-38	potassium voltage-gated channel subfamily A member 4	Homo sapiens	104-109
2117583-2	1990	TRH derives from a 242-amino acid precursor protein, prepro-TRH, with six repetitive sequences of -Lys-Arg-Gln-His-Pro-Gly-Lys/Arg)-Arg- connected by hydrophobic linking sequences.	Histidine	111-114	thyrotropin releasing hormone	Homo sapiens	0-3
15355340-5	2004	Here we report that 48 h after induction with methanol, soluble Gas1p was produced at a yield of approximately 10 mg x L(-1) of medium, and this value was unaffected by the further removal of the serine-rich region or by fusion to a 6 x His tag.	Histidine	237-240	1,3-beta-glucanosyltransferase GAS1	Saccharomyces cerevisiae S288C	64-69
15313924-1	2004	The antiangiogenic activity of the multidomain plasma protein histidine-proline-rich glycoprotein (HPRG) is localized to its histidine-proline-rich (H/P) domain and has recently been shown to be mediated, at least partially, through binding to cell-surface tropomyosin in fibroblast growth factor-2-activated endothelial cells (X. Guan et al., Thromb Haemost, in press).	Histidine	62-71	histidine-rich glycoprotein	Mus musculus	99-103
15225714-0	2004	Analogs of sub-nanomolar hMC1R agonist LK-184 [Ph(CH2)3CO-His-D-Phe-Arg-Trp-NH2].	Histidine	58-61	melanocortin 1 receptor	Homo sapiens	25-30
15225714-6	2004	This suggests the existence of an additional binding site within hMC1R next to that for the core sequence His-d-Phe-Arg-Trp-NH(2).	Histidine	106-109	melanocortin 1 receptor	Homo sapiens	65-70
28913669-10	2017	These studies identified a copper-binding site involving histidines at positions 2 and 3 that confers a remarkable stabilization of PAI-1 beyond what is observed with vitronectin alone.	Histidine	57-67	serpin family E member 1	Homo sapiens	132-137
28805803-4	2017	PGAM1 needs to be histidine phosphorylated to become catalytically active.	Histidine	18-27	phosphoglycerate mutase 1	Homo sapiens	0-5
28630069-5	2017	The kcat/Km values of recombinant DPP4s ranged from 721 +- 55 to 1,283 +- 23 muM-1s-1 toward Gly-Pro-4-methylcoumaryl-7-amide (MCA), while those were much lower for His-Ala-MCA.	Histidine	165-168	dipeptidyl peptidase 4	Homo sapiens	34-38
28630069-6	2017	Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) analysis showed His/Tyr-Ala dipeptide release from the N termini of incretins, glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide, respectively, with the action of microbial DPP4.	Histidine	108-111	dipeptidyl peptidase 4	Homo sapiens	296-300
2117583-3	1990	Antibodies to TRH-Gly (pGlu-His-Pro-Gly), a final precursor for TRH formation, were used to detect this tetrapeptide as well as other prepro-TRH fragments which cross-react with these antibodies.	Histidine	28-31	thyrotropin releasing hormone	Homo sapiens	14-17
15481890-5	2004	The DNA sequence of the alpha1 gene revealed a C--&gt;G transversion at position 89, changing the local positively charged histidine to a neutral glutamine.	Histidine	123-132	adrenoceptor alpha 1D	Homo sapiens	24-30
2117583-3	1990	Antibodies to TRH-Gly (pGlu-His-Pro-Gly), a final precursor for TRH formation, were used to detect this tetrapeptide as well as other prepro-TRH fragments which cross-react with these antibodies.	Histidine	28-31	thyrotropin releasing hormone	Homo sapiens	64-67
2117583-3	1990	Antibodies to TRH-Gly (pGlu-His-Pro-Gly), a final precursor for TRH formation, were used to detect this tetrapeptide as well as other prepro-TRH fragments which cross-react with these antibodies.	Histidine	28-31	thyrotropin releasing hormone	Homo sapiens	64-67
2117583-7	1990	A minor, TRH-Gly immunoreactive peak increased 50-fold (P less than 0.001) during 20 h at 60 degrees C. This material co-eluted with Arg-Gln-His-Pro-Gly which is formed by enzymic cleavage of the paired basic residues flanking this sequence in prepro-TRH.	Histidine	141-144	thyrotropin releasing hormone	Homo sapiens	9-12
15265919-0	2004	Histidines are critical for heparin-dependent activation of mast cell tryptase.	Histidine	0-10	tryptase alpha/beta 1	Mus musculus	70-78
2117583-8	1990	When synthetic Arg-Gln-His-Pro-Gly was incubated with fresh semen at 60 degrees C a rapid conversion of most of this peptide to Glu-His-Pro-Gly, Gln-His-Pro-Gly and TRH-Gly occurred within 30 min.	Histidine	23-26	thyrotropin releasing hormone	Homo sapiens	165-168
1691825-4	1990	In addition, Isl-1, like the lin-11 and mec-3 gene products, contains a novel Cys-His domain which is reminiscent of known metal-binding regions.	Histidine	82-85	Mechanosensory protein 3	Caenorhabditis elegans	40-45
15206929-2	2004	The cDNA encoding a C-terminally histidine-tagged (10xHis) human histamine H1 receptor was used to generate recombinant baculovirus in a Spodoptera frugiperda-derived cell line (IPLB-Sf9).	Histidine	33-42	histamine receptor H1	Homo sapiens	65-86
28332148-4	2017	Here, we demonstrate that HSPB1 responds to pH via a similar mechanism through pH-dependent structural changes that are induced via protonation of the structurally analogous histidine.	Histidine	174-183	heat shock protein family B (small) member 1	Homo sapiens	26-31
28277678-0	2017	Unravelling the Non-Native Low-Spin State of the Cytochrome c-Cardiolipin Complex: Evidence of the Formation of a His-Ligated Species Only.	Histidine	114-117	cytochrome c, somatic	Equus caballus	49-61
2108187-1	1990	The acute GH release stimulated by the synthetic hexapeptide, His-DTrp-Ala-Trp-DPhe-Lys-NH2 [GH releasing peptide (GHRP)], was determined in 18 normal men and compared with the effects of GH-releasing hormone, GHRH-(1-44)-NH2.	Histidine	62-65	growth hormone secretagogue receptor	Homo sapiens	93-113
26764162-2	2017	The self-assembled nanocomposite probe comprised of amino acid (histidine) functionalized perylenediimide (PDI-HIS), copper ion and graphene oxide (GO) and that could be utilized as a highly effective sensing platform in biological conditions and cellular environment via fluorescence "turn-on" for PPi detection.	Histidine	64-73	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	107-110
15218992-7	2004	During combined analysis of genetic polymorphisms for mEPHX, GSTM1 and GSTP1, it was found that there are strong indicators for susceptibility to COPD (genotype combination with at least one mutant mEPHX exon-3 allele (histidine 113), GSTM1 null and homozygous for the GSTPI isoleucine 105 allele).	Histidine	219-228	glutathione S-transferase pi 1	Homo sapiens	71-76
15135404-3	2004	Recombinant SAP (r-SAP) was produced in a bioreactor with computer controlled fed-batch mode and purified by use of a C-terminal histidine tag.	Histidine	129-138	amyloid P component, serum	Homo sapiens	12-15
15135404-3	2004	Recombinant SAP (r-SAP) was produced in a bioreactor with computer controlled fed-batch mode and purified by use of a C-terminal histidine tag.	Histidine	129-138	amyloid P component, serum	Homo sapiens	19-22
2108187-1	1990	The acute GH release stimulated by the synthetic hexapeptide, His-DTrp-Ala-Trp-DPhe-Lys-NH2 [GH releasing peptide (GHRP)], was determined in 18 normal men and compared with the effects of GH-releasing hormone, GHRH-(1-44)-NH2.	Histidine	62-65	growth hormone secretagogue receptor	Homo sapiens	115-119
2318937-5	1990	Polymorphisms in the nucleotide sequences for codons 523 (Ala), 1058 (His), and 1062 (Leu) provided useful markers to differentiate the patient"s two alleles of the insulin receptor gene.	Histidine	70-73	insulin receptor	Homo sapiens	165-181
15185439-2	2004	the mutations responsible are located in the CACNA1S gene (type 1) and in the SCN4A gene (type 2), and are all missense mutations where arginine is mostly replaced by histidine or sometimes glycine.	Histidine	167-176	sodium voltage-gated channel alpha subunit 4	Homo sapiens	78-83
15123430-1	2004	Production of seven single surface histidine variants of yeast iso-1-cytochrome c allowed measurement of the apparent pK(a), pK(a)(obs), for histidine-heme loop formation for loops of nine to 83 amino acid residues under varying denaturing conditions (2 M to 6 M guanidine hydrochloride, gdnHCl).	Histidine	35-44	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	63-68
2158826-6	1990	The distribution of histidine side-chain conformations in the TRH analogue was deduced from coupling constants and from the short-range interaction between the imidazole ring and one of the prochiral faces of the 2,4-MePro side chain.	Histidine	20-29	thyrotropin releasing hormone	Homo sapiens	62-65
15109246-2	2004	The IDO(II)NO adduct, which is likely to play a physiological role in the immune system, differs from similar adducts such as Mb(II)NO and Lb(II)NO in that the Fe-His bond is essentially broken.	Histidine	163-166	indoleamine 2,3-dioxygenase 1	Homo sapiens	4-7
2117689-0	1990	Oral activity of the growth hormone releasing peptide His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 in rats, dogs and monkeys.	Histidine	54-57	gonadotropin releasing hormone receptor	Rattus norvegicus	21-35
14982931-1	2004	Hint, histidine triad nucleotide-binding protein, is a universally conserved enzyme that hydrolyzes AMP linked to lysine and, in yeast, functions as a positive regulator of the RNA polymerase II C-terminal domain kinase, Kin28.	Histidine	6-15	adenosine 5'-monophosphoramidase HINT1	Oryctolagus cuniculus	0-4
14982931-1	2004	Hint, histidine triad nucleotide-binding protein, is a universally conserved enzyme that hydrolyzes AMP linked to lysine and, in yeast, functions as a positive regulator of the RNA polymerase II C-terminal domain kinase, Kin28.	Histidine	6-15	TFIIH complex serine/threonine-protein kinase subunit KIN28	Saccharomyces cerevisiae S288C	221-226
2117689-1	1990	The purpose of this study was to evaluate the growth hormone (GH) releasing activity of orally administered His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 (GHRP-6, SK&amp;F 110679) in rats, dogs and monkeys.	Histidine	108-111	gonadotropin releasing hormone receptor	Rattus norvegicus	46-60
15012592-0	2004	N-terminal His(7)-modification of glucagon-like peptide-1(7-36) amide generates dipeptidyl peptidase IV-stable analogues with potent antihyperglycaemic activity.	Histidine	11-14	dipeptidyl peptidase 4	Homo sapiens	80-103
2117689-1	1990	The purpose of this study was to evaluate the growth hormone (GH) releasing activity of orally administered His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 (GHRP-6, SK&amp;F 110679) in rats, dogs and monkeys.	Histidine	108-111	gonadotropin releasing hormone receptor	Rattus norvegicus	62-64
33815739-3	2021	Based on docking studies and molecular dynamics simulations of the protein structure and a chondroitin substrate, we suggest a novel mechanism of DS-epi1, involving a His/double-Tyr motif.	Histidine	167-170	dermatan sulfate epimerase	Homo sapiens	146-153
14762077-12	2004	Based on evolution of extraction rate and ratio of uptake to output, His and Leu could have limited the milk protein yield response to glucose infusions.	Histidine	69-72	PY	Bos taurus	104-122
12905028-9	2004	PHT1 and PHT2 were shown to transport free histidine and certain di- and tripeptides, but it is not yet clear whether they are located on the plasma membrane or represent lysosomal transporters for the proton-dependent export of histidine and dipeptides from lysosomal protein degradation into the cytosol.	Histidine	43-52	solute carrier family 15 member 4	Homo sapiens	0-4
12905028-9	2004	PHT1 and PHT2 were shown to transport free histidine and certain di- and tripeptides, but it is not yet clear whether they are located on the plasma membrane or represent lysosomal transporters for the proton-dependent export of histidine and dipeptides from lysosomal protein degradation into the cytosol.	Histidine	229-238	solute carrier family 15 member 4	Homo sapiens	0-4
7601289-4	1995	Magnetic/electronic asymmetry of heme induced by two axial His makes spread the hyperfine shifted heme carbon resonances over the range of 280 ppm at 25 degrees C, which would be the more sensitive probe than those of proton resonances in characterizing the nature of heme electronic structure of ferricytochrome b5.	Histidine	59-62	HEME	Bos taurus	33-37
14556652-8	2004	One of the ligands to the catalytic metal, His(5), was altered to glutamine, a side chain found in the Zn(2+)-active Homo sapiens GlxI.	Histidine	43-46	glyoxalase I	Homo sapiens	130-134
15471342-4	2004	One surprising result, which will be stressed in the discussion, is the observation of a distinct product state vibrational coherence (the iron-histidine stretching vibration of deoxy Mb at 220 cm(-1)) that depends upon the presence of pump field interactions having a wavelength mismatch that is equal to the 220 cm(-1) vibrational frequency.	Histidine	144-153	myoglobin	Homo sapiens	184-186
15752073-5	2004	However, the best sequence alignment we could obtain suggests that while catalytic Ser is conserved across Clp and SDH proteinases the location of the other catalytic triad residues, namely, His and Asp are swapped in their amino acid alignment positions and hence in 3-D structure.	Histidine	191-194	calmodulin like 3	Homo sapiens	107-110
7601289-4	1995	Magnetic/electronic asymmetry of heme induced by two axial His makes spread the hyperfine shifted heme carbon resonances over the range of 280 ppm at 25 degrees C, which would be the more sensitive probe than those of proton resonances in characterizing the nature of heme electronic structure of ferricytochrome b5.	Histidine	59-62	HEME	Bos taurus	98-102
14659886-1	2003	Human zinc-fingers and homeoboxes (ZHX) 1, ZHX2 and ZHX3, members of the ZHX family, contain two Cys(2)-His(2)-type zinc-finger motifs and five homeodomains (HDs).	Histidine	104-107	zinc fingers and homeoboxes 3	Mus musculus	52-56
7601289-4	1995	Magnetic/electronic asymmetry of heme induced by two axial His makes spread the hyperfine shifted heme carbon resonances over the range of 280 ppm at 25 degrees C, which would be the more sensitive probe than those of proton resonances in characterizing the nature of heme electronic structure of ferricytochrome b5.	Histidine	59-62	HEME	Bos taurus	98-102
34811564-7	2021	CS-His hydrogels demonstrate larger storage moduli than ELPs with other amino acids.	Histidine	3-6	citrate synthase	Homo sapiens	0-2
12959987-4	2003	L-Histidine (L-His) increases the sensitivity of the CaSR to extracellular Ca2+ and potentiates glucose-dependent insulin secretion from INS-1 cells.	Histidine	0-11	insulin 1	Rattus norvegicus	137-142
12959987-4	2003	L-Histidine (L-His) increases the sensitivity of the CaSR to extracellular Ca2+ and potentiates glucose-dependent insulin secretion from INS-1 cells.	Histidine	0-5	insulin 1	Rattus norvegicus	137-142
12837132-8	2003	Taken together, the selectivity of Abz-HPGGPQ-EDN2ph to cathepsin K primarily depends on the S2 and S2" subsite specificities of cathepsin K and the ionization state of histidine at P3.	Histidine	169-178	cathepsin K	Homo sapiens	56-67
34563592-4	2021	This carrier, known as the Hex carrier, is comprised of a self-assembling coiled coil hexamer at the core, with each alpha helix fused to a linker, an antibody binding domain, and a six Histidine-tag (His-tag).	Histidine	186-195	hematopoietically expressed homeobox	Homo sapiens	27-30
14519942-4	2003	Oral administration of histidine at 200 mg/kg once daily for 5 d before intravenous LPS injection increased the plasma alanine aminotransferase (ALT) activity to 2936.5+/-356.3 IU/l, a significant change compared with the controls (2244.8+/-425.5 IU/l, p&lt;0.05).	Histidine	23-32	glutamic pyruvic transaminase, soluble	Mus musculus	145-148
12860998-5	2003	Mutation of histidine residues 19 and 22 to leucine on the p21-binding domain of Pak5 completely abolished the binding of Cdc42 and the Cdc42-mediated autophosphorylation.	Histidine	12-21	p21 (RAC1) activated kinase 5	Homo sapiens	81-85
34563592-4	2021	This carrier, known as the Hex carrier, is comprised of a self-assembling coiled coil hexamer at the core, with each alpha helix fused to a linker, an antibody binding domain, and a six Histidine-tag (His-tag).	Histidine	201-204	hematopoietically expressed homeobox	Homo sapiens	27-30
34685411-0	2021	The Structure, Activity, and Function of the SETD3 Protein Histidine Methyltransferase.	Histidine	59-68	SET domain containing 3, actin histidine methyltransferase	Homo sapiens	45-50
12939145-1	2003	In the elucidation of structural requirements of heme vicinity for hydrogen peroxide activation, we found that the replacement of His-64 of myoglobin (Mb) with a negatively charged aspartate residue enhanced peroxidase and peroxygenase activities by 78- and 580-fold, respectively.	Histidine	130-133	myoglobin	Homo sapiens	140-149
12944466-7	2003	The interaction involves the I-mfa domain of HIC and the regulatory histidine-rich region of cyclin T1.	Histidine	68-77	MyoD family inhibitor domain containing	Homo sapiens	45-48
34685411-1	2021	SETD3 has been recently identified as a long sought, actin specific histidine methyltransferase that catalyzes the Ntau-methylation reaction of histidine 73 (H73) residue in human actin or its equivalent in other metazoans.	Histidine	68-77	SET domain containing 3, actin histidine methyltransferase	Homo sapiens	0-5
12873485-0	2003	Sub-nanomolar hMC1R agonists by end-capping of the melanocortin tetrapeptide His-D-Phe-Arg-Trp-NH(2).	Histidine	77-80	melanocortin 1 receptor	Homo sapiens	14-19
34685411-1	2021	SETD3 has been recently identified as a long sought, actin specific histidine methyltransferase that catalyzes the Ntau-methylation reaction of histidine 73 (H73) residue in human actin or its equivalent in other metazoans.	Histidine	144-153	SET domain containing 3, actin histidine methyltransferase	Homo sapiens	0-5
12873485-2	2003	The SAR within this series allowed us to map the hMCRs near the His(6) binding site and design a superpotent MC1R agonist, LK-184, Ph(CH(2))(3)CO-His-D-Phe-Arg-Trp-NH(2) (19) with EC(50) 0.01 nM (5 nM at MC3 and MC4Rs).	Histidine	64-67	melanocortin 1 receptor	Homo sapiens	109-113
12873485-2	2003	The SAR within this series allowed us to map the hMCRs near the His(6) binding site and design a superpotent MC1R agonist, LK-184, Ph(CH(2))(3)CO-His-D-Phe-Arg-Trp-NH(2) (19) with EC(50) 0.01 nM (5 nM at MC3 and MC4Rs).	Histidine	146-149	melanocortin 1 receptor	Homo sapiens	109-113
34327612-2	2021	The obtained recombinant Mb without His-tag showed non-cooperative thermal denaturation profile.	Histidine	36-39	myoglobin	Oncorhynchus mykiss	25-27
12905023-6	2003	Expression of AtGCN2 in yeast gcn2 mutants complemented the mutation, enabling growth in the presence of sulfometuron methyl, an inhibitor of branched-chain amino acid biosynthesis, and 3-aminotriazole, an inhibitor of histidine biosynthesis.	Histidine	219-228	protein kinase family protein	Arabidopsis thaliana	14-20
12672482-6	2003	The complete amino acid sequence of 157 residues of Theliostyla myoglobin shows that it has a long N-terminal extension of seven residues and contains three functional key residues: CD1-Phe, E7-His, and F8-His.	Histidine	194-197	myoglobin	Homo sapiens	64-73
34471328-0	2021	Rapid identification of histamine-producing bacteria isolated from fish using MALDI-TOF MS. Histamine-producing bacteria (HPB) produce histamine from histidine contained in food through the action of histidine decarboxylase.	Histidine	150-159	histidine decarboxylase	Homo sapiens	200-223
12672482-6	2003	The complete amino acid sequence of 157 residues of Theliostyla myoglobin shows that it has a long N-terminal extension of seven residues and contains three functional key residues: CD1-Phe, E7-His, and F8-His.	Histidine	206-209	myoglobin	Homo sapiens	64-73
12808042-10	2003	Instead, a conserved histidine (H434) present within a hydrophobic peptide segment, may be essential for ACAT catalysis.	Histidine	21-30	sterol O-acyltransferase 1	Cricetulus griseus	105-109
34630499-3	2021	Perception of cytokinin signaling involves (i) a hormone molecule binding to the CHASE domain, (ii) CRE1 autophosphorylation at a conserved His residue in the HK domain, followed by a phosphorelay to (iii) a conserved Asp residue in the REC domain, (iv) a histidine-containing phosphotransfer protein (HPt), and (v) a response regulator (RR).	Histidine	140-143	CHASE domain containing histidine kinase protein	Arabidopsis thaliana	100-104
12522007-0	2003	Iron transport by Nramp2/DMT1: pH regulation of transport by 2 histidines in transmembrane domain 6.	Histidine	63-73	solute carrier family 11 member 2	Homo sapiens	18-24
12522007-0	2003	Iron transport by Nramp2/DMT1: pH regulation of transport by 2 histidines in transmembrane domain 6.	Histidine	63-73	solute carrier family 11 member 2	Homo sapiens	25-29
28125045-3	2017	Here we show the binding of a soluble histidine tagged l-selectin to a recently described shortened variant of an l-selectin specific DNA aptamer with surface plasmon resonance.	Histidine	38-47	selectin L	Homo sapiens	55-65
28125045-3	2017	Here we show the binding of a soluble histidine tagged l-selectin to a recently described shortened variant of an l-selectin specific DNA aptamer with surface plasmon resonance.	Histidine	38-47	selectin L	Homo sapiens	114-124
34575967-7	2021	The functionality of His-tagged Caf1R was demonstrated in vivo, but insolubility was a problem with overproduction.	Histidine	21-24	F1 capsule positive regulator	Yersinia pestis	32-37
28107384-4	2017	A mutation to histidine in Q170 residue in olNbs1, which corresponds to Q185 residue of hNBS1, was widely distributed in the closed colonies derived from the eastern Korean population of medaka.	Histidine	14-23	nibrin	Homo sapiens	88-93
12711688-4	2003	The AtTFIIIA cDNA encodes a protein with nine Cys(2)-His(2)-type zinc fingers, a 23 amino acid spacer between fingers 1 and 2, a 66 amino acid spacer between fingers 4 and 5, and a 50 amino acid non-finger C-terminal tail.	Histidine	53-56	transcription factor IIIA	Arabidopsis thaliana	4-12
34452239-1	2021	The peptide hormone Angiotensin (1-7), Ang (1-7) or (Asp-Arg-Val-Tyr-Ile-His-Pro), is an essential component of the renin-angiotensin system (RAS) peripherally and is an agonist of the Mas receptor centrally.	Histidine	73-76	angiopoietin 1	Homo sapiens	39-47
12681501-0	2003	Histidine 454 plays an important role in polymerization of human glutamate dehydrogenase.	Histidine	0-9	glutamate dehydrogenase 1	Homo sapiens	65-88
27870532-0	2017	Distinguishing the Protonation State of the Histidine Ligand to the Oxidized Iron-Sulfur Cluster from the MitoNEET Family of Proteins.	Histidine	44-53	CDGSH iron sulfur domain 1	Homo sapiens	106-114
35397203-6	2022	In response to the flavin redox state, two conserved histidine residues contributed to a robust on/off switch by mediating CTT interactions with the flavin pocket and TIM.	Histidine	53-62	timeless	Drosophila melanogaster	167-170
27860283-3	2017	In the present study, we tested whether creation of an endogenous proton antenna by introduction of a cluster of histidine residues into the C-terminal tail of MCT4 (MCT4-6xHis) could facilitate MCT4 transport activity when heterologously expressed in Xenopus oocytes.	Histidine	113-122	solute carrier family 16 member 3 S homeolog	Xenopus laevis	160-164
27860283-3	2017	In the present study, we tested whether creation of an endogenous proton antenna by introduction of a cluster of histidine residues into the C-terminal tail of MCT4 (MCT4-6xHis) could facilitate MCT4 transport activity when heterologously expressed in Xenopus oocytes.	Histidine	113-122	solute carrier family 16 member 3 S homeolog	Xenopus laevis	166-176
27860283-3	2017	In the present study, we tested whether creation of an endogenous proton antenna by introduction of a cluster of histidine residues into the C-terminal tail of MCT4 (MCT4-6xHis) could facilitate MCT4 transport activity when heterologously expressed in Xenopus oocytes.	Histidine	113-122	solute carrier family 16 member 3 S homeolog	Xenopus laevis	166-170
27860283-4	2017	Our results show that integration of six histidines into the C-terminal tail does indeed increase transport activity of MCT4 to the same extent as did coexpression of MCT4-WT with CAII.	Histidine	41-51	solute carrier family 16 member 3	Homo sapiens	120-124
27860283-6	2017	Injection of an antibody against the histidine cluster into MCT4-expressing oocytes decreased transport activity of MCT4-6xHis, while leaving activity of MCT4-WT unaltered.	Histidine	37-46	solute carrier family 16 member 3	Homo sapiens	60-64
27860283-6	2017	Injection of an antibody against the histidine cluster into MCT4-expressing oocytes decreased transport activity of MCT4-6xHis, while leaving activity of MCT4-WT unaltered.	Histidine	37-46	solute carrier family 16 member 3	Homo sapiens	116-126
27860283-6	2017	Injection of an antibody against the histidine cluster into MCT4-expressing oocytes decreased transport activity of MCT4-6xHis, while leaving activity of MCT4-WT unaltered.	Histidine	37-46	solute carrier family 16 member 3	Homo sapiens	116-120
12551944-4	2003	Western blot revealed that YggB-His(6) oligomers are more stable in the presence of Ni(2+), providing evidence that Ni(2+) is coordinated between C termini from different subunits of the channel.	Histidine	32-35	hypothetical protein	Escherichia coli	27-31
12623125-4	2003	Human AhR and Arnt with a C-terminal histidine tag have been expressed functionally using a baculovirus expression system.	Histidine	37-46	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	14-18
35254116-1	2022	BACKGROUND: Fragile histidine triad (FHIT) is a strong tumor suppressor gene, and cells deficient in FHIT are prone to acquiring cancer-promoting mutations.	Histidine	20-29	fragile histidine triad diadenosine triphosphatase	Homo sapiens	37-41
12675566-3	2003	The highest G6PDH production (1164 U/L) and specific activity (517 U/g(cell)) were obtained using the following conditions: glucose, 5.0 g/L; adenine, 8 microg/mL; histidine, 8 microg/mL; tryptophan, 8 microg/mL; temperature, 30 degrees C; inoculum, 1.28 g/L; pH, 5.7; agitation, 400 rpm; aeration, 2.2 vvm; and K, 0.2 h(-)(1).	Histidine	164-173	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	12-17
12493732-5	2003	To gain mechanistic insight, we measured the effects of Saccharomyces cerevisiae Ssa1p (Hsp70) and Ydj1p (Hsp40) on the translocation of histidine-tagged prepro-alpha-factor (ppalphaF6H) into microsomes.	Histidine	137-146	Hsp70 family ATPase SSA1	Saccharomyces cerevisiae S288C	81-86
27792302-5	2016	Each STEAP1 protomer binds one heme prosthetic group that is mainly low-spin with a pair of histidine axial ligands, with small portions of high-spin and P450-type heme.	Histidine	92-101	STEAP family member 1	Homo sapiens	5-11
12458209-4	2003	The validity of using the crystal structure of UvrB as a template for the development of an XPD model was tested by mimicking human disease-causing mutations (XPD: R112H, D234N, R601L) in UvrB (E110R, D338N, R506A) and by mutating two highly conserved residues (XPD, His-237 and Asp-609; UvrB, H341A and D510A).	Histidine	267-270	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	92-95
35254116-1	2022	BACKGROUND: Fragile histidine triad (FHIT) is a strong tumor suppressor gene, and cells deficient in FHIT are prone to acquiring cancer-promoting mutations.	Histidine	20-29	fragile histidine triad diadenosine triphosphatase	Homo sapiens	101-105
35522782-1	2022	The tumor suppressor protein fragile histidine triad (Fhit) is known to be associated with genomic instability and apoptosis.	Histidine	37-46	fragile histidine triad diadenosine triphosphatase	Homo sapiens	54-58
12446736-2	2003	Like the other ZnT proteins, the protein (387 amino acids) predicted from this gene contains six transmembrane domains and a histidine-rich loop between transmembrane domains IV and V. We show that Znt7 is widely transcribed in mouse tissues with abundant expression in the liver and small intestine and moderate expression in the kidney, spleen, brain, and lung.	Histidine	125-134	solute carrier family 30 (zinc transporter), member 7	Mus musculus	198-202
12540540-4	2003	Immunization of mice with His-tag Cbp or His-tag Csp did not provide effective protection against the lethal activity of His-tag Cpa.	Histidine	26-29	phosphoprotein associated with glycosphingolipid microdomains 1	Mus musculus	34-37
12867744-4	2003	These organisms also possess (1) HPr, the substrate for HprK/P; (2) enzyme I, which phosphorylates HPr at His-15, and (3) one or several enzymes IIA, which receive the phosphoryl group from P approximately His-HPr.	Histidine	106-109	colicin Ia immunity protein	Escherichia coli	145-148
27580602-11	2016	In addition, a fused histidine-tagged cecropin b-human epidermal growth factor (CB-EGF) from Escherichia coli crude extract was purified by the Ni(II)-chelated stationary phase, and the purity of the CB-EGF was determined to be at least 90 %.	Histidine	21-30	epidermal growth factor	Homo sapiens	55-78
27807034-4	2016	CNOT3 interacts with EBF1, and we identified histidine 240 in EBF1 as a critical residue for this interaction.	Histidine	45-54	early B cell factor 1	Mus musculus	21-25
27807034-4	2016	CNOT3 interacts with EBF1, and we identified histidine 240 in EBF1 as a critical residue for this interaction.	Histidine	45-54	early B cell factor 1	Mus musculus	62-66
35151127-2	2022	The obtained Ni-NTA@SiO2 nanoflowers were used to specifically adsorb and purify His-tagged old yellow enzyme (OYE1) and glucose dehydrogenase (GDH), which allows access to optically pure (3 S)- 3-methyl-cyclohexanone through asymmetric hydrogenation reaction, and forms a cofactor regeneration system.	Histidine	81-84	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	121-142
29741343-0	2016	[Ubiquitination regulation of histidine transporter Hip1p on histidine utilization in Saccharomyces cerevisiae].	Histidine	30-39	histidine permease	Saccharomyces cerevisiae S288C	52-57
12509991-9	2003	Six His residues at the C terminus of human TyrRS have little effect on the activities of the enzyme compared with other eukaryotic TyrRSs.	Histidine	4-7	tyrosyl-tRNA synthetase 1	Homo sapiens	44-49
35151127-2	2022	The obtained Ni-NTA@SiO2 nanoflowers were used to specifically adsorb and purify His-tagged old yellow enzyme (OYE1) and glucose dehydrogenase (GDH), which allows access to optically pure (3 S)- 3-methyl-cyclohexanone through asymmetric hydrogenation reaction, and forms a cofactor regeneration system.	Histidine	81-84	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	144-147
12270930-4	2002	Experiments with substitution mutants showed that tyrosine 571, histidine 572, and their flanking leucine and isoleucine amino acids, which are all highly conserved in many fas-1 domains, are essential for mediating MRC-5 cell adhesion.	Histidine	64-73	Fas cell surface death receptor	Homo sapiens	173-178
35216047-0	2022	Mechanistic Insights into the Polymorphic Associations and Cross-Seeding of Abeta and hIAPP in the Presence of Histidine Tautomerism: An All-Atom Molecular Dynamic Study.	Histidine	111-120	islet amyloid polypeptide	Homo sapiens	86-91
26510381-3	2016	In this study, we have selected hydroxamic acid derivatives as HDACi and performed fragment-based G-QSAR, molecular docking studies and molecular dynamics simulations for elucidating the dynamic mode of action of HDACi with His-Asp catalytic dyad of HDAC4.	Histidine	224-227	histone deacetylase 4	Homo sapiens	250-255
26510381-9	2016	The interaction of the compounds with His-Asp dyad in terms of H-bond interactions with His802, Asp840, Pro942, and Gly975 residues of HDAC4 was evaluated by docking and 20 ns long molecular dynamics simulations.	Histidine	38-41	histone deacetylase 4	Homo sapiens	135-140
27346274-11	2016	Additional mutants in EC1/TM3 explored the molecular basis for these changes demonstrated in EC1, particularly important is the presence of aromatic-interactions by His(107), rather than hydrogen-bonding or charge-charge interactions, for determining Bantag-1 high affinity/selectivity.	Histidine	165-168	Susceptibility to lysis by alloreactive natural killer cells	Homo sapiens	22-25
12531019-8	2002	Pull-down of hOgg1 by histidine-tagged CSB and co-localization of those two proteins after gamma-radiation indicated their co-existence in vivo, particularly under cellular stress.	Histidine	22-31	8-oxoguanine DNA glycosylase	Homo sapiens	13-18
27346274-11	2016	Additional mutants in EC1/TM3 explored the molecular basis for these changes demonstrated in EC1, particularly important is the presence of aromatic-interactions by His(107), rather than hydrogen-bonding or charge-charge interactions, for determining Bantag-1 high affinity/selectivity.	Histidine	165-168	Susceptibility to lysis by alloreactive natural killer cells	Homo sapiens	93-96
2611202-0	1989	Effect of the distal histidine modification (Cyanation) of myoglobin on the ligand binding kinetics and the heme environmental structures.	Histidine	21-30	myoglobin	Homo sapiens	59-68
27453048-2	2016	Here we show that phosphoglycerate mutase family 5 (PGAM5) functions as a phosphohistidine phosphatase that specifically associates with and dephosphorylates the catalytic histidine on nucleoside diphosphate kinase B (NDPK-B).	Histidine	81-90	PGAM family member 5, mitochondrial serine/threonine protein phosphatase	Homo sapiens	18-50
27453048-2	2016	Here we show that phosphoglycerate mutase family 5 (PGAM5) functions as a phosphohistidine phosphatase that specifically associates with and dephosphorylates the catalytic histidine on nucleoside diphosphate kinase B (NDPK-B).	Histidine	81-90	PGAM family member 5, mitochondrial serine/threonine protein phosphatase	Homo sapiens	52-57
27453048-2	2016	Here we show that phosphoglycerate mutase family 5 (PGAM5) functions as a phosphohistidine phosphatase that specifically associates with and dephosphorylates the catalytic histidine on nucleoside diphosphate kinase B (NDPK-B).	Histidine	81-90	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	185-216
27453048-2	2016	Here we show that phosphoglycerate mutase family 5 (PGAM5) functions as a phosphohistidine phosphatase that specifically associates with and dephosphorylates the catalytic histidine on nucleoside diphosphate kinase B (NDPK-B).	Histidine	81-90	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	218-224
27453048-3	2016	By dephosphorylating NDPK-B, PGAM5 negatively regulates CD4(+) T cells by inhibiting NDPK-B-mediated histidine phosphorylation and activation of the K(+) channel KCa3.1, which is required for TCR-stimulated Ca(2+) influx and cytokine production.	Histidine	101-110	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	21-27
27453048-3	2016	By dephosphorylating NDPK-B, PGAM5 negatively regulates CD4(+) T cells by inhibiting NDPK-B-mediated histidine phosphorylation and activation of the K(+) channel KCa3.1, which is required for TCR-stimulated Ca(2+) influx and cytokine production.	Histidine	101-110	PGAM family member 5, mitochondrial serine/threonine protein phosphatase	Homo sapiens	29-34
27453048-3	2016	By dephosphorylating NDPK-B, PGAM5 negatively regulates CD4(+) T cells by inhibiting NDPK-B-mediated histidine phosphorylation and activation of the K(+) channel KCa3.1, which is required for TCR-stimulated Ca(2+) influx and cytokine production.	Histidine	101-110	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	85-91
27414641-0	2016	A Cytolethal Distending Toxin Variant from Aggregatibacter actinomycetemcomitans with an Aberrant CdtB That Lacks the Conserved Catalytic Histidine 160.	Histidine	138-147	corneal dystrophy of Bowman's layer type II (Thiel-Behnke)	Homo sapiens	98-102
27399771-5	2016	The primary structure of N. nomurai CTRL-1 includes a leader peptide and a highly conserved catalytic triad of His(69), Asp(117), and Ser(216).	Histidine	111-114	chymotrypsin like	Homo sapiens	36-40
26476866-8	2016	In addition to these we have also observed a significant binding site for l-histidine and histidyl moieties at Fab region of IgG.	Histidine	74-85	FA complementation group B	Homo sapiens	111-114
26593463-0	2016	Solubilisation of myosin in a solution of low ionic strength L-histidine: Significance of the imidazole ring.	Histidine	61-72	myosin heavy chain 14	Homo sapiens	18-24
26593463-1	2016	Myosin, a major muscle protein, can be solubilised in a low ionic strength solution containing L-histidine (His).	Histidine	95-106	myosin heavy chain 14	Homo sapiens	0-6
26593463-1	2016	Myosin, a major muscle protein, can be solubilised in a low ionic strength solution containing L-histidine (His).	Histidine	108-111	myosin heavy chain 14	Homo sapiens	0-6
26593463-5	2016	Therefore, the imidazole ring of His appeared to be the significant chemical constituent in solubilising myosin at low ionic strength solution, presumably by affecting its secondary structure.	Histidine	33-36	myosin heavy chain 14	Homo sapiens	105-111
25759426-8	2016	The recombinant TGFalphaL3-SEB fusion protein with molecular weight of 31 kDa was expressed and confirmed by anti-His Western-blot analysis.	Histidine	114-117	seborrheic dermatitis	Mus musculus	27-30
26927547-3	2016	The fragment containing Oct4 gene, amplified by reverse transcription PCR (RT-PCR) from human HeLa cell cDNA as the template, was subcloned into pET-22b(+) and pcDNA3.1(+) vectors to construct the gene recombinant prokaryotic expression vector pET-22b(+)-Oct4 and eukaryotic expression vector pcDNA3.1(+)-his-Oct4, respectively.	Histidine	305-308	POU class 5 homeobox 1	Homo sapiens	24-28
26927547-5	2016	The prokaryotic expression vector pET-22b(+)-Oct4 and eukaryotic expression vector pcDNA3.1(+)- his-Oct4 from the positive clones were respectively transformed into E.coli BL21 (DE3) and the embryo HEK293T cells for protein expression.	Histidine	96-99	POU class 5 homeobox 1	Homo sapiens	100-104
27524954-6	2016	Our findings suggest that insertion of a His-tag at the N-terminal or C-terminal end of ZNF191(243-368) has different effects on the protein.	Histidine	41-44	zinc finger protein 24	Homo sapiens	88-94
26900445-3	2016	Mutagenesis of the "distal" histidine residue was particularly effective in enhancing the azide oxidation reactivity of myoglobin, enabling these reactions to proceed in good to excellent yields (37-89%) and to be carried out at a synthetically useful scale.	Histidine	28-37	myoglobin	Homo sapiens	120-129
27631796-5	2016	We describe the bacterial expression and purification of all complex components, namely an 86 kDa His-tagged RanBP2 fragment, the SUMO E2-conjugating enzyme Ubc9, RanGAP1, and SUMO1, and we provide a protocol for quantitative SUMOylation of RanGAP1.	Histidine	98-101	RAN binding protein 2	Homo sapiens	109-115
26235215-0	2015	The reaction of a platinated methionine motif of CTR1 with cysteine and histidine is dependent upon the type of precursor platinum complex.	Histidine	72-81	solute carrier family 31 member 1	Homo sapiens	49-53
26195630-6	2015	In contrast, mutations in the C-terminal hinge-cysteine-histidine-rich domain segment primarily affected the PCSK9-induced CD81 degradation.	Histidine	56-65	proprotein convertase subtilisin/kexin type 9	Homo sapiens	109-114
26195630-7	2015	Furthermore, when C-terminally fused to an ACE2 transmembrane anchor, the secretory N-terminal catalytic or hinge-cysteine-histidine-rich domain domains of PCSK9 were able to reduce CD81 and LDLR levels.	Histidine	123-132	proprotein convertase subtilisin/kexin type 9	Homo sapiens	156-161
26195630-7	2015	Furthermore, when C-terminally fused to an ACE2 transmembrane anchor, the secretory N-terminal catalytic or hinge-cysteine-histidine-rich domain domains of PCSK9 were able to reduce CD81 and LDLR levels.	Histidine	123-132	low density lipoprotein receptor	Homo sapiens	191-195
26337119-6	2015	The imidazole ring of L-Histidine captures the Cd ions from the solution, and prevents the growth of the CdS nanoparticles.	Histidine	22-33	CDP-diacylglycerol synthase 1	Homo sapiens	105-108
26337119-7	2015	Furthermore, the photocatalytic contrast experiments illustrate that the as-synthesized flower-like CdS with L-Histidine is more stable than CdS without L-Histidine in the hydrogen generation.	Histidine	109-120	CDP-diacylglycerol synthase 1	Homo sapiens	100-103
26337119-7	2015	Furthermore, the photocatalytic contrast experiments illustrate that the as-synthesized flower-like CdS with L-Histidine is more stable than CdS without L-Histidine in the hydrogen generation.	Histidine	153-164	CDP-diacylglycerol synthase 1	Homo sapiens	100-103
26213944-3	2015	A peptide receptor (His-Pro-Asn-Phe-Ser-Lys-Tyr-Ile-Leu-His-Gln-Arg) that has high binding affinity for 2,4-DNT was immobilized on the surface of the cantilever sensors to detect 2,4-DNT vapor for highly selective detection.	Histidine	20-23	5', 3'-nucleotidase, cytosolic	Homo sapiens	108-111
26213944-3	2015	A peptide receptor (His-Pro-Asn-Phe-Ser-Lys-Tyr-Ile-Leu-His-Gln-Arg) that has high binding affinity for 2,4-DNT was immobilized on the surface of the cantilever sensors to detect 2,4-DNT vapor for highly selective detection.	Histidine	20-23	5', 3'-nucleotidase, cytosolic	Homo sapiens	183-186
26213944-3	2015	A peptide receptor (His-Pro-Asn-Phe-Ser-Lys-Tyr-Ile-Leu-His-Gln-Arg) that has high binding affinity for 2,4-DNT was immobilized on the surface of the cantilever sensors to detect 2,4-DNT vapor for highly selective detection.	Histidine	56-59	5', 3'-nucleotidase, cytosolic	Homo sapiens	108-111
26001783-11	2015	Carnosine and Gly-His were the best substrates for all UPF0586 orthologs studied, although the enzymes also methylated other l-histidine-containing di- and tripeptides.	Histidine	125-136	carnosine N-methyltransferase 1	Homo sapiens	55-62
26013822-5	2015	The acid-induced dissociation of RAP is mediated by its D3 domain, a relatively unstable three-helical bundle that denatures at pH &lt;6.2 due to protonation of key histidine residues on helices 2 and 3.	Histidine	165-174	LDL receptor related protein associated protein 1	Homo sapiens	33-36
26013822-7	2015	By combining this disulfide bond with elimination of key histidine residues, we generated a stable RAP molecule that is resistant to both pH- and heat-induced denaturation.	Histidine	57-66	LDL receptor related protein associated protein 1	Homo sapiens	99-102
25863146-6	2015	Domain 5 of CI-MPR was expressed in Escherichia coli BL21 (DE3) cells as a fusion protein containing an N-terminal histidine tag and the small ubiquitin-like modifier (SUMO) protein.	Histidine	115-124	insulin like growth factor 2 receptor	Homo sapiens	12-18
25960268-5	2015	Moreover, the H174R mutation of the HxD-histidine, in the tumor suppressor LKB1 abrogates the inhibition of anchorage-independent growth of A549 cells by WT LKB1.	Histidine	40-49	serine/threonine kinase 11	Homo sapiens	75-79
25960268-5	2015	Moreover, the H174R mutation of the HxD-histidine, in the tumor suppressor LKB1 abrogates the inhibition of anchorage-independent growth of A549 cells by WT LKB1.	Histidine	40-49	serine/threonine kinase 11	Homo sapiens	157-161
25923690-5	2015	Overall, the pooled results indicated that the EPHX1 Tyr113His polymorphism was significantly associated with increased HNC risk (Tyr/His vs. Tyr/Tyr, OR = 1.26, 95%1.02-1.57;His/His+ Tyr/His vs. Tyr/Tyr, OR = 1.29, 95% I = 1.03-1.61).	Histidine	59-62	epoxide hydrolase 1	Homo sapiens	47-52
25923690-5	2015	Overall, the pooled results indicated that the EPHX1 Tyr113His polymorphism was significantly associated with increased HNC risk (Tyr/His vs. Tyr/Tyr, OR = 1.26, 95%1.02-1.57;His/His+ Tyr/His vs. Tyr/Tyr, OR = 1.29, 95% I = 1.03-1.61).	Histidine	134-137	epoxide hydrolase 1	Homo sapiens	47-52
25923690-5	2015	Overall, the pooled results indicated that the EPHX1 Tyr113His polymorphism was significantly associated with increased HNC risk (Tyr/His vs. Tyr/Tyr, OR = 1.26, 95%1.02-1.57;His/His+ Tyr/His vs. Tyr/Tyr, OR = 1.29, 95% I = 1.03-1.61).	Histidine	134-137	epoxide hydrolase 1	Homo sapiens	47-52
25923690-5	2015	Overall, the pooled results indicated that the EPHX1 Tyr113His polymorphism was significantly associated with increased HNC risk (Tyr/His vs. Tyr/Tyr, OR = 1.26, 95%1.02-1.57;His/His+ Tyr/His vs. Tyr/Tyr, OR = 1.29, 95% I = 1.03-1.61).	Histidine	134-137	epoxide hydrolase 1	Homo sapiens	47-52
25689174-0	2015	A novel synthetic derivative of melatonin, 5-hydroxy-2"-isobutyl-streptochlorin (HIS), inhibits inflammatory responses via regulation of TRIF-dependent signaling and inflammasome activation.	Histidine	81-84	toll-like receptor adaptor molecule 1	Mus musculus	137-141
25689174-9	2015	Mechanistic studies revealed that the inhibitory effects of HIS were mediated through the regulation of the TIR domain-containing, adaptor-inducing, interferon-beta (TRIF)-dependent signaling pathway from toll-like receptors.	Histidine	60-63	toll-like receptor adaptor molecule 1	Mus musculus	108-164
25689174-9	2015	Mechanistic studies revealed that the inhibitory effects of HIS were mediated through the regulation of the TIR domain-containing, adaptor-inducing, interferon-beta (TRIF)-dependent signaling pathway from toll-like receptors.	Histidine	60-63	toll-like receptor adaptor molecule 1	Mus musculus	166-170
25760390-2	2015	C-terminal His extension of dap (L = 2GH) instead of Gly (L = 3G) lowers the pKa for Cu(III)H-2L (9.36 vs. 9.98) and improves the TOF at pH 11 (53 vs. 24 s(-1)).	Histidine	11-14	FEZ family zinc finger 2	Homo sapiens	130-133
25803856-2	2015	This activation is due to the coordination of nickel by a cluster of histidine residues on the ectodomain of human TLR4, which is absent in most other species.	Histidine	69-78	toll like receptor 4	Homo sapiens	115-119
25803856-6	2015	Activation of TLR4 by cobalt required MD-2 and was abolished by human TLR4 mutations of histidine residues at positions 456 and 458.	Histidine	88-97	toll like receptor 4	Homo sapiens	14-18
25803856-6	2015	Activation of TLR4 by cobalt required MD-2 and was abolished by human TLR4 mutations of histidine residues at positions 456 and 458.	Histidine	88-97	toll like receptor 4	Homo sapiens	70-74
25306337-5	2015	These results demonstrate that the introduction of L-lys and L-his causes the unfolding of myosin, resulting in loss of alpha-helical structure, which is followed by increases in random coils, beta-turns and beta-sheets, which exposes buried hydrophobic and sulphydryl groups to the myosin surface, ultimately increasing the solubility of porcine myosin.	Histidine	61-66	myosin heavy chain 14	Homo sapiens	91-97
25306337-5	2015	These results demonstrate that the introduction of L-lys and L-his causes the unfolding of myosin, resulting in loss of alpha-helical structure, which is followed by increases in random coils, beta-turns and beta-sheets, which exposes buried hydrophobic and sulphydryl groups to the myosin surface, ultimately increasing the solubility of porcine myosin.	Histidine	61-66	myosin heavy chain 14	Homo sapiens	283-289
25306337-5	2015	These results demonstrate that the introduction of L-lys and L-his causes the unfolding of myosin, resulting in loss of alpha-helical structure, which is followed by increases in random coils, beta-turns and beta-sheets, which exposes buried hydrophobic and sulphydryl groups to the myosin surface, ultimately increasing the solubility of porcine myosin.	Histidine	61-66	myosin heavy chain 14	Homo sapiens	283-289
25853107-2	2015	In particular, missense mutations in isocitrate dehydrogenase-1 (IDH1) at arginine 132, mostly substituted into histidine (IDH1-R132H) were observed to frequently occur in glioma patients.	Histidine	112-121	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	37-63
25853107-2	2015	In particular, missense mutations in isocitrate dehydrogenase-1 (IDH1) at arginine 132, mostly substituted into histidine (IDH1-R132H) were observed to frequently occur in glioma patients.	Histidine	112-121	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	65-69
25853107-2	2015	In particular, missense mutations in isocitrate dehydrogenase-1 (IDH1) at arginine 132, mostly substituted into histidine (IDH1-R132H) were observed to frequently occur in glioma patients.	Histidine	112-121	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	123-127
25655782-4	2015	The former 2 antibodies (7S1 and 10S2) had a high affinity for both GPVI-His and GPVI-Fc, while the latter 2 antibodies (19D1 and 21D1) showed a high affinity for GPVI-Fc but low affinity for GPVI-His.	Histidine	73-76	glycoprotein VI platelet	Homo sapiens	68-72
25761704-7	2015	24 hours after HI, TRPM7 protein level in the ipsilateral hemisphere was significantly higher than in the contralateral hemisphere.	Histidine	15-17	transient receptor potential cation channel, subfamily M, member 7	Rattus norvegicus	19-24
25742191-15	2015	In the example presented, the His3 enzyme, which is required for histidine biosynthesis, was fused to Deg1-Sec62.	Histidine	65-74	pseudouridine synthase DEG1	Saccharomyces cerevisiae S288C	102-106
25742191-15	2015	In the example presented, the His3 enzyme, which is required for histidine biosynthesis, was fused to Deg1-Sec62.	Histidine	65-74	Sec63 complex subunit SEC62	Saccharomyces cerevisiae S288C	107-112
25561737-8	2015	In CAII, binding to MCT1 and MCT4 is mediated by a histidine residue at position 64.	Histidine	51-60	solute carrier family 16 member 3 S homeolog	Xenopus laevis	29-33
25438246-6	2015	In the present study, histidine based pseudobioaffinity adsorbents have been used for the selective adsorption and separation of anti-double stranded DNA (anti-dsDNA), anticardiolipin (aCL) and anti-beta2-glycoprotein-I (anti-beta2-GPI) antibodies from sera of patients with SLE.	Histidine	22-31	apolipoprotein H	Homo sapiens	226-235
26095376-1	2015	An alpha-MSH peptide analogue, named MTII (Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]- NH2), is one of the most important ligands of melanotropic receptors but are relatively nonselective.	Histidine	56-59	metallothionein 2A	Homo sapiens	37-41
25342750-5	2014	We identified the cysteine- and histidine-rich domain containing 1 (CHORDC1) as a novel host factor target of miR-26b.	Histidine	32-41	microRNA 26b	Homo sapiens	110-117
25012655-3	2014	The C-terminal phosphoglycerate mutase domain of PGAM5 shares homology with the catalytic domains found in other members of the phosphoglycerate mutase family, including a conserved histidine that is absolutely required for catalytic activity.	Histidine	182-191	PGAM family member 5, mitochondrial serine/threonine protein phosphatase	Homo sapiens	49-54
25140899-5	2014	By modulating the amino acid sequence of alpha-synuclein at only two positions in which we introduced a pair of histidine residues found in Abeta, we created a chimeric alpha-synuclein/Abeta peptide with extended ganglioside-binding properties.	Histidine	112-121	synuclein alpha	Homo sapiens	41-56
25140899-5	2014	By modulating the amino acid sequence of alpha-synuclein at only two positions in which we introduced a pair of histidine residues found in Abeta, we created a chimeric alpha-synuclein/Abeta peptide with extended ganglioside-binding properties.	Histidine	112-121	synuclein alpha	Homo sapiens	169-184
24816719-7	2014	FAD2 proteins include highly conserved histidine-rich motifs (HECGHH, HRRHH and HV[A/C/T]HH) that are located by three to five transmembrane anchors.	Histidine	39-48	omega-6 fatty acid desaturase, endoplasmic reticulum isozyme 2	Sesamum indicum	0-4
25068395-3	2014	Here, presteady-state and steady-state kinetics of the PSA-catalyzed hydrolysis of the fluorogenic substrate Mu-His-Ser-Ser-Lys-Leu-Gln-AMC (spanning from pH 6.5 to pH 9.0, at 37.0 C) are reported.	Histidine	112-115	kallikrein related peptidase 3	Homo sapiens	55-58
24590270-3	2014	Mutations of IDH1 have been identified at codon 132, with arginine being replaced with histidine in most cases.	Histidine	87-96	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	13-17
24706745-4	2014	In sharp contrast, mice homozygous for a point mutation in the Prss8 gene, which causes the substitution of the active site serine within the catalytic histidine-aspartate-serine triad with alanine and renders prostasin catalytically inactive (Prss8(Cat-/Cat-) mice), develop barrier function and are healthy when followed for up to 20 weeks.	Histidine	152-161	protease, serine 8 (prostasin)	Mus musculus	63-68
24970226-7	2014	XAS on HPRG isolated from the AMPD complex showed that zinc is bound to the protein in a dinuclear cluster where each Zn2+ ion is coordinated by three histidine and one heavier ligand, likely sulfur from cysteine.	Histidine	151-160	adenosine monophosphate deaminase 1	Homo sapiens	30-34
24626950-4	2014	The present study, showed that forced expression of an IDH1 mutant, of which the 132th amino acid residue arginine is substituted by histidine (IDH1R132H), promoted cell proliferation in cultured cells, while wild-type IDH1 overexpression had no effect on cell proliferation.	Histidine	133-142	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	55-59
24626950-4	2014	The present study, showed that forced expression of an IDH1 mutant, of which the 132th amino acid residue arginine is substituted by histidine (IDH1R132H), promoted cell proliferation in cultured cells, while wild-type IDH1 overexpression had no effect on cell proliferation.	Histidine	133-142	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	144-148
24733123-9	2014	Using specific beta-adrenoceptor antagonists, HIS-induced visceral hypersensitivity was alleviated by beta2 adrenoceptor antagonist but not by beta1- or beta3-adrenoceptor antagonist.	Histidine	46-49	adrenoceptor beta 2	Rattus norvegicus	102-120
23235339-2	2014	The most common IDH1 mutation affects codon 132 and results in the conversion of amino acid residue arginine (R) to histidine (H).	Histidine	116-125	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	16-20
24523290-0	2014	Regulation of the epithelial Ca2+ channel TRPV5 by reversible histidine phosphorylation mediated by NDPK-B and PHPT1.	Histidine	62-71	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	100-106
24523290-3	2014	Here we show that the histidine kinase, nucleoside diphosphate kinase B (NDPK-B), activates TRPV5 channel activity and Ca(2+) flux, and this activation requires histidine 711 in the carboxy-terminal tail of TRPV5.	Histidine	22-31	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	40-71
24523290-3	2014	Here we show that the histidine kinase, nucleoside diphosphate kinase B (NDPK-B), activates TRPV5 channel activity and Ca(2+) flux, and this activation requires histidine 711 in the carboxy-terminal tail of TRPV5.	Histidine	22-31	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	73-79
24509845-7	2014	We show that, contrary to the previously reported structures, Sgf73 ZnF adopts a C2H2 coordination with unusual tautomeric forms for the coordinating histidines.	Histidine	150-160	deubiquitination module subunit SGF73	Saccharomyces cerevisiae S288C	62-67
24606199-0	2014	Imidazole C-2 hydrogen/deuterium exchange reaction at histidine for probing protein structure and function with matrix-assisted laser desorption ionization mass spectrometry.	Histidine	54-63	complement C2	Homo sapiens	10-13
24548272-1	2014	In eukaryotes, the tRNA(His) guanylyltransferase (Thg1) catalyzes 3"-5" addition of a single guanosine residue to the -1 position (G-1) of tRNA(His), across from a highly conserved adenosine at position 73 (A73).	Histidine	24-27	tRNA guanylyltransferase	Saccharomyces cerevisiae S288C	50-54
24422557-3	2014	The first step is the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-l-methionine (SAM) to the histidine residue of EF2, forming a C-C bond.	Histidine	110-119	eukaryotic translation elongation factor 2	Homo sapiens	131-134
24714493-5	2014	Modification of MICOS subunits Mic12 or Mic26 by His-tags in the absence of Aim24 leads to complete loss of cristae and respiratory complexes.	Histidine	49-52	apolipoprotein O	Homo sapiens	40-45
23932357-1	2014	Increasing concentration of histidine significantly increased stearidonic acid production and cell growth in oleaginous Saccharomyces cerevisiae that has been genetically modified by Deltasnf2 disruption, DGA1 and Delta6 desaturase gene overexpression, and LEU2 expression.	Histidine	28-37	diacylglycerol O-acyltransferase	Saccharomyces cerevisiae S288C	205-209
24056062-6	2013	A histidine stretch disrupts CGPD1 continuity in Otx1 determining its loss of CG promoting activity; this histidine-rich region acts as an actively CG repressing domain.	Histidine	2-11	orthodenticle homeobox 1 L homeolog	Xenopus laevis	49-53
24056062-6	2013	A histidine stretch disrupts CGPD1 continuity in Otx1 determining its loss of CG promoting activity; this histidine-rich region acts as an actively CG repressing domain.	Histidine	106-115	orthodenticle homeobox 1 L homeolog	Xenopus laevis	49-53
24037091-2	2013	Here, we show that after acute myocardial infarction in mice, mature B lymphocytes selectively produce Ccl7 and induce Ly6C(hi) monocyte mobilization and recruitment to the heart, leading to enhanced tissue injury and deterioration of myocardial function.	Histidine	124-126	lymphocyte antigen 6 complex, locus C1	Mus musculus	119-123
24043698-6	2013	http://dx.doi.org/10.1083/jcb.201308034) show that pHi increase activates FAK by causing deprotonation of histidine 58 in its FERM (band 4.1, ezrin, radixin, moesin) homology domain, which exposes a region important for FAK autophosphorylation.	Histidine	106-115	ezrin	Homo sapiens	142-148
23679855-4	2013	Huprine W in hAChE and tacrine in hBChE reside in strikingly similar positions highlighting the conservation of key interactions, namely, pi-pi/cation-pi interactions with Trp86 (Trp82), and hydrogen bonding with the main chain carbonyl of the catalytic histidine residue.	Histidine	254-263	butyrylcholinesterase	Homo sapiens	34-39
23686495-8	2013	The E2 region contained a predicted Lck substrate site, and substitution of an alanine or histidine for the tyrosine reversed TCR-signaling inhibition.	Histidine	90-99	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	126-129
23575474-0	2013	Effect of distal histidines on hydrogen peroxide activation by manganese reconstituted myoglobin.	Histidine	17-27	myoglobin	Homo sapiens	87-96
22961760-0	2013	Disruption of the histidine triad nucleotide-binding hint2 gene in mice affects glycemic control and mitochondrial function.	Histidine	18-27	histidine triad nucleotide binding protein 2	Mus musculus	53-58
22961760-1	2013	UNLABELLED: The histidine triad nucleotide-binding (HINT2) protein is a mitochondrial adenosine phosphoramidase expressed in the liver and pancreas.	Histidine	16-25	histidine triad nucleotide binding protein 2	Mus musculus	52-57
23772397-0	2013	Zinc-binding and structural properties of the histidine-rich loop of Arabidopsis thaliana vacuolar membrane zinc transporter MTP1.	Histidine	46-55	zinc transporter	Arabidopsis thaliana	125-129
23772397-1	2013	The vacuolar Zn(2+)/H(+) antiporter of Arabidopsis thaliana, AtMTP1, has a cytosolic histidine-rich loop (His-loop).	Histidine	85-94	zinc transporter	Arabidopsis thaliana	61-67
23772397-1	2013	The vacuolar Zn(2+)/H(+) antiporter of Arabidopsis thaliana, AtMTP1, has a cytosolic histidine-rich loop (His-loop).	Histidine	106-109	zinc transporter	Arabidopsis thaliana	61-67
23510298-0	2013	Involvement of histidine residues in the pH-dependent beta-galactoside binding activity of human galectin-1.	Histidine	15-24	galectin 1	Homo sapiens	97-107
22867050-5	2013	RESULTS: Incubation with HNE promoted the oligomerization of recombinant human alpha-synuclein via adduct formation at the lysine and histidine residues.	Histidine	134-143	synuclein alpha	Homo sapiens	79-94
23297402-1	2013	Since the elucidation of the myoglobin (Mb) structure, a histidine residue on the E helix (His-E7) has been proposed to act as a gate with an open or closed conformation controlling access to the active site.	Histidine	57-66	myoglobin	Homo sapiens	29-38
23297402-1	2013	Since the elucidation of the myoglobin (Mb) structure, a histidine residue on the E helix (His-E7) has been proposed to act as a gate with an open or closed conformation controlling access to the active site.	Histidine	57-66	myoglobin	Homo sapiens	40-42
23297402-1	2013	Since the elucidation of the myoglobin (Mb) structure, a histidine residue on the E helix (His-E7) has been proposed to act as a gate with an open or closed conformation controlling access to the active site.	Histidine	91-94	myoglobin	Homo sapiens	29-38
23297402-1	2013	Since the elucidation of the myoglobin (Mb) structure, a histidine residue on the E helix (His-E7) has been proposed to act as a gate with an open or closed conformation controlling access to the active site.	Histidine	91-94	myoglobin	Homo sapiens	40-42
12419835-10	2002	Selective caspase 9 inhibitor [z-Leu-Glu(OMe)-His-Asp(OMe)-FMK] showed only partial inhibition of GSE-induced apoptosis whereas GSE-induced protease activity of caspase 9 was completely inhibited.	Histidine	46-49	caspase 9	Homo sapiens	10-19
12546417-2	2002	ERG25p contains three histidine clusters common to nonheme iron binding enzymes and endoplasmic reticulum retrieval signal.	Histidine	22-31	methylsterol monooxygenase	Saccharomyces cerevisiae S288C	0-6
12193598-6	2002	The Erf2p/Erf4p complex is required for Ras PAT activity, and mutations within conserved residues (Cys(189), His(201), and Cys(203)) of the Erf2p DHHC-CRD domain abolish Ras PAT activity.	Histidine	109-112	palmitoyltransferase ERF2	Saccharomyces cerevisiae S288C	4-9
12193598-6	2002	The Erf2p/Erf4p complex is required for Ras PAT activity, and mutations within conserved residues (Cys(189), His(201), and Cys(203)) of the Erf2p DHHC-CRD domain abolish Ras PAT activity.	Histidine	109-112	palmitoyltransferase ERF2	Saccharomyces cerevisiae S288C	140-145
12459266-5	2002	The presence of this motif, together with a conserved order and spacing of the Ser, Asp, and His residues that form the catalytic triad in DPP IV, places DPP9 in the "DPP IV gene family".	Histidine	93-96	dipeptidyl peptidase 4	Homo sapiens	167-173
12241546-4	2002	An anti-cathepsin L monoclonal antibody (mAb), named 3D8, was isolated from mice immunized with purified procathepsin L-His.	Histidine	118-123	cathepsin L	Mus musculus	8-19
12045193-7	2002	The crystal structure of S100A3 allows the prediction of one putative Zn(2+) binding site in the C terminus of each subunit of S100A3 involving Cys and His residues in the coordination of the metal ion.	Histidine	152-155	S100 calcium binding protein A3	Homo sapiens	25-31
12045193-7	2002	The crystal structure of S100A3 allows the prediction of one putative Zn(2+) binding site in the C terminus of each subunit of S100A3 involving Cys and His residues in the coordination of the metal ion.	Histidine	152-155	S100 calcium binding protein A3	Homo sapiens	127-133
12199707-3	2002	By site-directed mutagenesis we have produced three mutants of cyt b5: Phe35--&gt;Tyr, Phe35--&gt;Leu, and Phe35--&gt;His.	Histidine	118-121	cytochrome b5 type A	Homo sapiens	63-69
12161759-2	2002	We demonstrate this approach for granulocyte colony-stimulating factor by using computationally predicted histidine substitutions that switch protonation states between cell-surface and endosomal pH.	Histidine	106-115	colony stimulating factor 3	Homo sapiens	33-70
11986319-2	2002	In this study, we identified His(308) and Arg(277) residues as essential determinants for the donor substrate (UDP-glucuronic acid) selectivity of the human GlcAT-I.	Histidine	29-32	beta-1,3-glucuronyltransferase 3	Homo sapiens	157-164
11986319-10	2002	Our results are consistent with crucial interactions between the His(308) and Arg(277) residues and the glucuronic acid moiety that governs the specificity of GlcAT-I toward the nucleotide sugar donor substrate.	Histidine	65-68	beta-1,3-glucuronyltransferase 3	Homo sapiens	159-166
12065763-6	2002	Substituting this histidine with arginine not only accelerated the time course of macroscopic channel inactivation but also eliminated the H+ effects on hKv1.4.	Histidine	18-27	potassium voltage-gated channel subfamily A member 4	Homo sapiens	153-159
12070317-1	2002	Nucleoside diphosphate (NDP) kinase is transiently phosphorylated on a histidine of the active site during the catalytic cycle.	Histidine	71-80	cytidine/uridine monophosphate kinase 2	Homo sapiens	0-35
12070317-3	2002	We describe the synthesis of an analog of the phosphoenzyme intermediate with an inactive mutant of NDP kinase in which the catalytic histidine is replaced by a cysteine.	Histidine	134-143	cytidine/uridine monophosphate kinase 2	Homo sapiens	100-110
12110368-3	2002	Since several other enzymes of intermediary metabolism (e.g. ATP-citrate lyase and glucose-6-phosphatase) also undergo histidine phosphorylation, these initial findings may have a more generalized significance to beta cells.	Histidine	119-128	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	83-104
12069902-7	2002	Point mutations were created to exchange the histidine and aspartate residues of the alpha1 and alpha5 subunits.	Histidine	45-54	adrenoceptor alpha 1D	Homo sapiens	85-91
11850428-7	2002	The mutation of MBP-A His(189) to its MBP-C equivalent, valine, causes Man alpha 1-3Man to bind in a mixture of orientations.	Histidine	22-25	mannose binding lectin 2	Homo sapiens	38-43
11973426-8	2002	Furthermore, intracerebral ventricular infusion of the relatively specific caspase-9 inhibitor N-benzyloxycarbonyl-Leu-Glu-His-Asp-fluoro-methylketone before ischemia attenuated caspase-3-like activity and significantly enhanced neuronal survival in the CA1 sector.	Histidine	123-126	caspase-3-like	Rattus norvegicus	178-192
11973426-8	2002	Furthermore, intracerebral ventricular infusion of the relatively specific caspase-9 inhibitor N-benzyloxycarbonyl-Leu-Glu-His-Asp-fluoro-methylketone before ischemia attenuated caspase-3-like activity and significantly enhanced neuronal survival in the CA1 sector.	Histidine	123-126	carbonic anhydrase 1	Rattus norvegicus	254-257
11906734-3	2002	A plasmid was constructed encoding a recombinant P22 with a Histidine-tag at its N-terminal extremity (P22r).	Histidine	60-69	calcineurin like EF-hand protein 1	Homo sapiens	49-52
11805111-1	2002	The histidine triad superfamily of nucleotide hydrolases and nucleotide transferases consists of a branch of proteins related to Hint and Aprataxin, a branch of Fhit-related hydrolases, and a branch of galactose-1-phosphate uridylyltransferase (GalT)-related transferases.	Histidine	4-13	adenosine 5'-monophosphoramidase HINT1	Oryctolagus cuniculus	129-133
12419163-9	2002	In Western blot analysis, the single domain antibody from 2 of 4 clones proved to react with the His-tagged hTERT fusion protein (Mr = 167 000) without dependence of His-tags and also detect the native hTERT (Mr = 127 000) extracted from the human HeLa cancer cell line.	Histidine	97-100	telomerase reverse transcriptase	Homo sapiens	108-113
11781309-8	2002	Furthermore, mutations in this lysine and in a histidine residue that is also predicted to be important for pyridoxal 5"-phosphate binding to Lcb2p also dominantly inactivate SPT similar to the hereditary sensory neuropathy type 1-like mutations in Lcb1p.	Histidine	47-56	serine C-palmitoyltransferase LCB1	Saccharomyces cerevisiae S288C	249-254
11901108-3	2002	We now show that mutation of a highly conserved histidine residue in Npt1p results in a silencing defect, indicating that Npt1p enzymatic activity is required for silencing.	Histidine	48-57	nicotinate phosphoribosyltransferase	Saccharomyces cerevisiae S288C	69-74
11901108-3	2002	We now show that mutation of a highly conserved histidine residue in Npt1p results in a silencing defect, indicating that Npt1p enzymatic activity is required for silencing.	Histidine	48-57	nicotinate phosphoribosyltransferase	Saccharomyces cerevisiae S288C	122-127
11707435-4	2002	To study the ion selectivity of the AtNHX1 protein, we have purified a histidine-tagged version of the protein from yeast microsomes by Ni(2+) affinity chromatography, reconstituted the protein into lipid vesicles, and measured cation-dependent H(+) exchange with the fluorescent pH indicator pyranine.	Histidine	71-80	Na+/H+ exchanger 1	Arabidopsis thaliana	36-42
11802740-0	2002	Rapid intrachain binding of histidine-26 and histidine-33 to heme in unfolded ferrocytochrome C. Time-resolved spectroscopic studies of unfolded horse iron(II) cytochrome c have suggested that the imidazole side chains of His26 and His33 bind transiently to the heme iron on microsecond time scales, after photodissociation of a carbon monoxide ligand from the heme.	Histidine	28-37	cytochrome c, somatic	Equus caballus	160-172
11802740-3	2002	Transient binding of these histidine side chains to the heme therefore generates one of the fast kinetic phases observed in previous photochemically triggered spectroscopic studies of dynamics in unfolded iron(II) cytochrome c.	Histidine	27-36	cytochrome c, somatic	Equus caballus	214-226
11814878-1	2002	N-Bromosuccinimide (NBS) is a known protein reagent able to modify amino acids and proteins, resulting in oxidation of tryptophan, tyrosine and histidine residues, as well as sulfhydryl, alcohol and phenol groups.	Histidine	144-153	nibrin	Homo sapiens	20-23
20569305-4	2002	Expression of AAT1p in a histidine uptake-defective yeast mutant revealed energy-dependent transport of (14)C-histidine, with a K(M) value of 25.8 microm.	Histidine	25-34	aspartate transaminase AAT1	Saccharomyces cerevisiae S288C	14-19
20569305-6	2002	Using Xenopus oocytes as expression system, AAT1p-dependent symport of protons with a broad spectrum of amino acids was observed, with the highest activities obtained with histidine and lysine.	Histidine	172-181	aspartate transaminase AAT1	Saccharomyces cerevisiae S288C	44-49
11527975-6	2001	SKCa3 was rendered sensitive to Lei-Dab(7) by replacing His(521) with the corresponding SKCa2 residue (Asn(367)).	Histidine	56-59	potassium calcium-activated channel subfamily N member 3	Homo sapiens	0-5
11597395-3	2001	GC109 harbours a putative Cys-His cluster, a nuclear localisation signal, a leucine zipper and a ret finger protein (rfp)-like domain.	Histidine	30-33	tripartite motif containing 68	Homo sapiens	0-5
11676607-7	2001	Insertion of a small oligopeptide (13 amino acids) containing the histidine hexamer and factor Xa cleavage site between the signal peptide and the mature hG-CSF protein allowed successful secretion of hG-CSF into the periplasm without cell lysis.	Histidine	66-75	colony stimulating factor 3	Homo sapiens	201-207
11687974-4	2001	5qNCA encodes a 191-kD nuclear protein which contains a highly-conserved C-terminus containing a zinc finger with the unique spacing Cys-X2-Cys-X7-His-X2-Cys-X2-Cys-X4-Cys-X2-Cys and a jmjC domain, which is often found in proteins that regulate chromatin remodeling.	Histidine	147-150	lysine demethylase 3B	Homo sapiens	0-5
11567902-3	2001	Three active sites characteristic for cathepsin B were conserved in the deduced amino acid sequences of BmCtB cDNA at positions Cys-111, His-280 and Asn-300.	Histidine	137-140	cathepsin B	Bombyx mori	38-49
11677272-3	2001	We prepared two His-tagged recombinant 7B2s by overexpression in bacteria: 7B2-Ser-Ser (SS), with an inactivating mutation in the CT peptide from Lys171-Lys172 (KK) to SS, rendering the CT peptide non-inhibitory; blockade-SS, a double mutant of both the CT peptide as well as of the pentabasic furin cleavage site.	Histidine	16-19	secretogranin V	Homo sapiens	39-42
11447225-5	2001	Recombinant His(6)-Plk3 phosphorylated glutathione S-transferase (GST)-p53 fusion protein but not GST alone.	Histidine	12-15	glutathione S-transferase kappa 1	Homo sapiens	39-64
11447225-5	2001	Recombinant His(6)-Plk3 phosphorylated glutathione S-transferase (GST)-p53 fusion protein but not GST alone.	Histidine	12-15	glutathione S-transferase kappa 1	Homo sapiens	66-69
11313341-5	2001	Ascidian acrosin has paired basic residues (Lys(56)-His(57)) in the N-terminal region, which is one of the most characteristic features of mammalian acrosin.	Histidine	52-55	acrosin	Homo sapiens	9-16
11313341-5	2001	Ascidian acrosin has paired basic residues (Lys(56)-His(57)) in the N-terminal region, which is one of the most characteristic features of mammalian acrosin.	Histidine	52-55	acrosin	Homo sapiens	149-156
11415453-4	2001	Mutation of the active-site residues Asp(88) or His(118) within the human PP2A catalytic subunit (PP2Ac)alpha impaired catalytic activity in vitro; the D88N and H118N substitutions caused a 9- and 23-fold reduction in specific activity respectively, when compared with wild-type recombinant PP2Ac, indicating an important role for these residues in catalysis.	Histidine	48-51	protein phosphatase 2 phosphatase activator	Homo sapiens	74-78
11415453-4	2001	Mutation of the active-site residues Asp(88) or His(118) within the human PP2A catalytic subunit (PP2Ac)alpha impaired catalytic activity in vitro; the D88N and H118N substitutions caused a 9- and 23-fold reduction in specific activity respectively, when compared with wild-type recombinant PP2Ac, indicating an important role for these residues in catalysis.	Histidine	48-51	protein phosphatase 2 catalytic subunit alpha	Homo sapiens	98-103
11396977-3	2001	The soluble cytosolic His(6)-hAR demonstrated similar association and dissociation half-times for mibolerone, similar binding affinity for mibolerone, and similar steroid specificity as bona fide AR.	Histidine	22-25	lymphatic vessel endothelial hyaluronan receptor 1	Homo sapiens	29-32
11396977-3	2001	The soluble cytosolic His(6)-hAR demonstrated similar association and dissociation half-times for mibolerone, similar binding affinity for mibolerone, and similar steroid specificity as bona fide AR.	Histidine	22-25	lymphatic vessel endothelial hyaluronan receptor 1	Homo sapiens	30-32
11380262-4	2001	As expected, mutation of the P1 arginine to tryptophan, histidine, leucine, and methionine converted the specificity of antithrombin from a trypsin inhibitor (k(assoc) = 2 x 10(5) M(-1) s(-1)) to a chymotrypsin inhibitor (k(assoc) = 10(3)-10(5) M(-1) s(-1)).	Histidine	56-65	serpin family C member 1	Homo sapiens	120-132
11341833-2	2001	We have previously shown by proton NMR that horse serum butyryl cholinesterase, like serine proteases, forms a short, strong hydrogen bond (SSHB) between the Glu-His pair upon binding mechanism-based inhibitors, which form tetrahedral adducts, analogous to the tetrahedral intermediates in catalysis [Viragh, C., et al.	Histidine	162-165	butyrylcholinesterase	Homo sapiens	56-78
11278664-4	2001	Because the pH dependence of ST8Sia II and IV enzyme activities and the pK profile of His residues are similar, we hypothesized that a histidine residue would be involved in their catalytic activity.	Histidine	135-144	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	Homo sapiens	29-38
11278664-6	2001	His(348) in ST8Sia II and His(331) in ST8Sia IV, respectively) within the sialyl motif VS in all sialyltransferase genes cloned to date.	Histidine	0-3	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	Homo sapiens	12-21
11457012-0	2001	Raman spectroscopic and electrochemical characterization of myoglobin thin film: implication of the role of histidine 64 for fast heterogeneous electron transfer.	Histidine	108-117	myoglobin	Homo sapiens	60-69
11124949-0	2001	Role of two histidines in the (6-4) photolyase reaction.	Histidine	12-22	6-4 photolyase	Xenopus laevis	31-46
11124949-2	2001	In the active site, which is homologous between the cis,syn-cyclobutane pyrimidine dimer and (6-4) photolyases, four amino acid residues that are specific to (6-4) photolyase, Gln(288), His(354), Leu(355), and His(358), and two conserved tryptophans, Trp(291) and Trp(398), were substituted with alanine.	Histidine	186-189	6-4 photolyase	Xenopus laevis	94-109
11124949-2	2001	In the active site, which is homologous between the cis,syn-cyclobutane pyrimidine dimer and (6-4) photolyases, four amino acid residues that are specific to (6-4) photolyase, Gln(288), His(354), Leu(355), and His(358), and two conserved tryptophans, Trp(291) and Trp(398), were substituted with alanine.	Histidine	210-213	6-4 photolyase	Xenopus laevis	94-109
11124949-5	2001	Taking the pH profile of the (6-4) photolyase reaction into consideration with this observation, we propose a mechanism in which these histidines catalyze the formation of the four-membered ring intermediate in the repair process of this enzyme.	Histidine	135-145	6-4 photolyase	Xenopus laevis	30-45
11080498-10	2001	The reverse substitution of Ser by His in PMA2 resulted in the failure of this enzyme to complement the absence of yeast H(+)-ATPases.	Histidine	35-38	H(+)-exporting P2-type ATPase PMA2	Saccharomyces cerevisiae S288C	42-46
11237694-1	2001	We succeeded in the expression, purification, and refolding of the immunoglobulin-like (Ig) domain of human granulocyte-colony-stimulating factor (G-CSF) receptor with amino-terminal His-tag in Escherichia coli.	Histidine	183-186	colony stimulating factor 3 receptor	Homo sapiens	108-162
11237694-3	2001	The eluted His-Ig/G-CSF complex could be separated from excess G-CSF by Ni-NTA column chromatography.	Histidine	11-14	colony stimulating factor 3	Homo sapiens	18-23
11237694-3	2001	The eluted His-Ig/G-CSF complex could be separated from excess G-CSF by Ni-NTA column chromatography.	Histidine	11-14	colony stimulating factor 3	Homo sapiens	63-68
11237699-1	2001	A histidine-tagged, carboxy-terminal fragment of the murine double minute 2 gene product, p90(MDM2), was purified by Ni--NTA chromatography and preparative gel electrophoresis.	Histidine	2-11	transformed mouse 3T3 cell double minute 2	Mus musculus	94-98
11082042-3	2000	The deduced amino acid sequence of porcine thyroid cathepsin K predicted a 37 kDa preproenzyme, with the active site residues Cys-140, His-277 and Asn-297, and one potential N-glycosylation site.	Histidine	135-138	cathepsin K	Homo sapiens	51-62
11029294-10	2000	Other contributors to the distinct pH sensitivity were histidine residues in the COOH terminus, whose numbers are fewer in Kir4.1 than Kir1.1.	Histidine	55-64	potassium inwardly rectifying channel subfamily J member 10	Homo sapiens	123-129
11029294-11	2000	Mutation of two of these histidine residues in Kir1.1 (H342Q/H354N) reduced CO(2)/pH sensitivities, whereas the creation of two histidines (S328H/G340H) in Kir4.1 increased the CO(2)/pH sensitivities.	Histidine	25-34	potassium inwardly rectifying channel subfamily J member 10	Homo sapiens	156-162
11205269-0	2000	Failure of detection of the tyrosine to histidine substitution at the residue 33 of thymidylate synthase in human colorectal cancer.	Histidine	40-49	thymidylate synthetase	Homo sapiens	84-104
11060015-1	2000	The solution structure of the second protein-protein complex of the Escherichia coli phosphoenolpyruvate: sugar phosphotransferase system, that between histidine-containing phosphocarrier protein (HPr) and glucose-specific enzyme IIA(Glucose) (IIA(Glc)), has been determined by NMR spectroscopy, including the use of dipolar couplings to provide long-range orientational information and newly developed rigid body minimization and constrained/restrained simulated annealing methods.	Histidine	152-161	colicin Ia immunity protein	Escherichia coli	230-252
11089639-11	2000	The model predicted a pattern of interactions between amino acids and DNA bases which reflect for ARNT what is experimentally observed among different X-ray structures of other bHLH transcription factors possessing the H (His), E (Glu), R (Arg) triad, as ARNT does.	Histidine	222-225	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	98-102
11089639-11	2000	The model predicted a pattern of interactions between amino acids and DNA bases which reflect for ARNT what is experimentally observed among different X-ray structures of other bHLH transcription factors possessing the H (His), E (Glu), R (Arg) triad, as ARNT does.	Histidine	222-225	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	255-259
10869342-9	2000	Identification of a modified histidine and analysis of cobU mutants indicate that histidine 46 is the site of guanylylation.	Histidine	82-91	bifunctional adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase	Salmonella enterica subsp. enterica serovar Typhimurium str. LT2	55-59
11027165-3	2000	A recombinant vaccinia virus/T7 RNA polymerase expression system was developed to express and produce large amounts of gp120 tagged with six histidine residues.	Histidine	141-150	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	119-124
11042490-2	2000	Plasmids with point mutations in ecoRII gene resulting in substitutions of amino acid residues in the Asp110-Glu112 region of the EcoRII endonuclease (Asp110 --&gt; Lys, Asn, Thr, Val, or Ile; Pro111 --&gt; Arg, His, Ala, or Leu; Glu112 --&gt; Lys, Gln, or Asp) have been constructed.	Histidine	212-215	EcoRII restriction enzyme	Escherichia coli	33-39
11042490-2	2000	Plasmids with point mutations in ecoRII gene resulting in substitutions of amino acid residues in the Asp110-Glu112 region of the EcoRII endonuclease (Asp110 --&gt; Lys, Asn, Thr, Val, or Ile; Pro111 --&gt; Arg, His, Ala, or Leu; Glu112 --&gt; Lys, Gln, or Asp) have been constructed.	Histidine	212-215	EcoRII restriction enzyme	Escherichia coli	130-136
10926844-8	2000	Mutation of two adjacent histidine residues within the predicted active site severely decreases activity, confirming these residues as important for HDAC8 enzyme activity.	Histidine	25-34	histone deacetylase 8	Homo sapiens	149-154
10887113-7	2000	Through these interactions, HKa or its recombinant His-Gly-Lys-rich domain 5 completely inhibited the uPAR-dependent adhesion of myelomonocytic U937 cells and uPAR-transfected BAF-3 cells to VN and thereby promoted cell detachment.	Histidine	51-54	plasminogen activator, urokinase receptor	Homo sapiens	102-106
10887113-7	2000	Through these interactions, HKa or its recombinant His-Gly-Lys-rich domain 5 completely inhibited the uPAR-dependent adhesion of myelomonocytic U937 cells and uPAR-transfected BAF-3 cells to VN and thereby promoted cell detachment.	Histidine	51-54	plasminogen activator, urokinase receptor	Homo sapiens	159-163
10908322-2	2000	Mutant forms of hOgg1 with mutations Arg(46)--&gt;Gln (alpha-hOgg1-Gln(46)) and Arg(154)--&gt;His (alpha-hOgg1-His(154)) have previously been identified in human tumors.	Histidine	94-97	8-oxoguanine DNA glycosylase	Homo sapiens	16-21
10908322-2	2000	Mutant forms of hOgg1 with mutations Arg(46)--&gt;Gln (alpha-hOgg1-Gln(46)) and Arg(154)--&gt;His (alpha-hOgg1-His(154)) have previously been identified in human tumors.	Histidine	111-114	8-oxoguanine DNA glycosylase	Homo sapiens	16-21
10908322-3	2000	The mutant proteins alpha-hOgg1-Gln(46) and alpha-hOgg1-His(154) were expressed in Escherichia coli and purified to homogeneity.	Histidine	56-59	8-oxoguanine DNA glycosylase	Homo sapiens	50-55
10832103-4	2000	Introduction of single mutations into either of the histidine residues at positions 136 and 272, putative active sites, entirely abolished the activity, supporting a common mechanism for the nSMase family independent of the species.	Histidine	52-61	sphingomyelin phosphodiesterase 2	Rattus norvegicus	191-197
10832103-5	2000	However, mutation in histidine 151, conserved only in eukaryotes, also abolished the activity, suggesting eukaryote-specific control of nSMase linked to this histidine 151.	Histidine	21-30	sphingomyelin phosphodiesterase 2	Rattus norvegicus	136-142
10832103-5	2000	However, mutation in histidine 151, conserved only in eukaryotes, also abolished the activity, suggesting eukaryote-specific control of nSMase linked to this histidine 151.	Histidine	158-167	sphingomyelin phosphodiesterase 2	Rattus norvegicus	136-142
10821667-1	2000	Cytochrome b(5) (cyt b(5)) holds heme using two axial histidines, His63 and His39, that are located in the centers of the two heme-binding loops.	Histidine	54-64	cytochrome b5 type A	Homo sapiens	0-15
10821667-1	2000	Cytochrome b(5) (cyt b(5)) holds heme using two axial histidines, His63 and His39, that are located in the centers of the two heme-binding loops.	Histidine	54-64	cytochrome b5 type A	Homo sapiens	17-25
10801361-0	2000	Coupled kinetic traps in cytochrome c folding: His-heme misligation and proline isomerization.	Histidine	47-50	cytochrome c, somatic	Equus caballus	25-37
10801361-2	2000	The variant contains a single misligating His residue at position 26, a location at which His residues are found in several cytochrome c homologues, including horse, tuna, and yeast iso-1.	Histidine	42-45	cytochrome c, somatic	Equus caballus	124-136
10801361-2	2000	The variant contains a single misligating His residue at position 26, a location at which His residues are found in several cytochrome c homologues, including horse, tuna, and yeast iso-1.	Histidine	42-45	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	182-187
10799485-3	2000	Like yeast Ulp1, SUSP1 is a cysteine protease containing the well conserved His/Asp/Cys catalytic triad.	Histidine	76-79	SUMO protease ULP1	Saccharomyces cerevisiae S288C	11-15
10788795-1	2000	The ArcB sensor plays a crucial role in the histidine to aspartate (His-to-Asp) phosphorelay signal transduction, which is involved in the transcriptional regulatory network that allows Escherichia coli cells to sense various respiratory growth conditions.	Histidine	44-53	hypothetical protein	Escherichia coli	4-8
10788795-1	2000	The ArcB sensor plays a crucial role in the histidine to aspartate (His-to-Asp) phosphorelay signal transduction, which is involved in the transcriptional regulatory network that allows Escherichia coli cells to sense various respiratory growth conditions.	Histidine	68-71	hypothetical protein	Escherichia coli	4-8
10788795-2	2000	ArcB is one of the best-studied hybrid His-kinases involved in the multi-step His-to-Asp phosphorelay.	Histidine	39-42	hypothetical protein	Escherichia coli	0-4
10708444-7	2000	Furthermore, using proteins expressed in Escherichia coli, a glutathione S-transferase-Nef fusion protein coprecipitated histidine-tagged portions of the TCR zeta cytoplasmic domain which contained SNID-1 or SNID-2.	Histidine	121-130	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	154-157
10712555-0	2000	Molecular cloning and characterization of ATP-phosphoribosyl transferase from Arabidopsis, a key enzyme in the histidine biosynthetic pathway.	Histidine	111-120	ATP phosphoribosyl transferase 1	Arabidopsis thaliana	42-72
10684599-13	2000	In particular, CDR1 provides a strong interaction to the hapten through two histidine residues bound to its copper atoms.	Histidine	76-85	cerebellar degeneration related protein 1	Homo sapiens	15-19
10672011-8	2000	Analysis of CD spectra suggests an overall fold similar to that of the CCHH fingers, and indeed a point mutant of FOG-F1 in which the final cysteine residue is replaced by histidine remains capable of folding.	Histidine	172-181	folded gastrulation	Drosophila melanogaster	114-117
10676874-0	2000	A critical histidine in the vesicular acetylcholine transporter.	Histidine	11-20	solute carrier family 18 member A3	Homo sapiens	28-63
10667598-6	2000	However, we also discovered that a subset of TTD cells, in which arg112 in the NH2-terminal region of the XPD protein is mutated to histidine, had an ICAM-1 response similar to that of XP-D cells.	Histidine	132-141	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	106-109
10601301-5	1999	The Delta-5 desaturase contains two membrane-spanning domains, three histidine-rich regions, and a cytochrome b(5) domain that all align perfectly with the same domains located in the Delta-6 desaturase.	Histidine	69-78	fatty acid desaturase 1	Homo sapiens	4-22
10585483-4	1999	ArcB is a tripartite kinase, possessing a primary transmitter, a receiver, and a secondary transmitter domain that catalyzes the phosphorylation of ArcA via a His --&gt; Asp --&gt; His --&gt; Asp phosphorelay, as well as the dephosphorylation of ArcA-P by a reverse phosphorelay.	Histidine	181-184	hypothetical protein	Escherichia coli	0-4
10658591-4	1999	The amino acids found to be important for MDL103,392 binding to the NK-1 receptor are Gln-165, His-197, Leu-203, Ile-204, Phe-264, His-265 and Tyr-272.	Histidine	95-98	tachykinin receptor 1	Homo sapiens	68-81
10658591-4	1999	The amino acids found to be important for MDL103,392 binding to the NK-1 receptor are Gln-165, His-197, Leu-203, Ile-204, Phe-264, His-265 and Tyr-272.	Histidine	131-134	tachykinin receptor 1	Homo sapiens	68-81
10625445-4	1999	The displacement from an interface with cytochrome c(1) in native crystals to an interface with cytochrome b is induced by stigmatellin or 5-n-undecyl-6-hydroxy-4,7-dioxobenzothiazole (UHDBT) and involves ligand formation between His-161 of the [2Fe-2S] binding cluster and the inhibitor.	Histidine	230-233	cytochrome c, somatic	Gallus gallus	40-52
10506413-6	1999	Starting with the NusA/hIL-3 fusion protein with an N-terminal histidine tag, purified hIL-3 with full biological activity was obtained using immobilized metal affinity chromatography, factor Xa protease cleavage, and anion exchange chromatography.	Histidine	63-72	interleukin 3	Homo sapiens	87-92
10531349-7	1999	These interactions probably involve sulfate groups in the glycosaminoglycans and positively charged histidine residues in GM-CSF.	Histidine	100-109	colony stimulating factor 2	Homo sapiens	122-128
10556563-8	1999	The other two cleavage sites in alpha(2)M by lebetase are Gly(679)-Leu(680) and His(694)-Ala(695).	Histidine	80-83	alpha-2-macroglobulin	Homo sapiens	32-41
10441372-5	1999	The His-CytKIR was tyrosine phosphorylated by Lck in vitro, and the phosphorylated His-CytKIR recruited SHP-1.	Histidine	4-7	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	46-49
10451024-6	1999	GST-AA-NAT enzyme activity is also inhibited by reagents that are known biochemically to modify thiol groups (N-ethylmaleimide, NEM) and histidine residues (p-chloromercuribenzoate, NBS and diethyl pyrocarbonate, DEPC), suggesting the presence of essential cysteine and histidine moieties.	Histidine	137-146	aralkylamine N-acetyltransferase	Rattus norvegicus	4-10
10451024-6	1999	GST-AA-NAT enzyme activity is also inhibited by reagents that are known biochemically to modify thiol groups (N-ethylmaleimide, NEM) and histidine residues (p-chloromercuribenzoate, NBS and diethyl pyrocarbonate, DEPC), suggesting the presence of essential cysteine and histidine moieties.	Histidine	270-279	aralkylamine N-acetyltransferase	Rattus norvegicus	4-10
10451024-7	1999	Moreover, preincubation of acetyl CoA completely protects the recombinant AA-NAT from inactivation by NEM and DEPC, indicating that specific cysteine and histidine residues may be at the acetylation site.	Histidine	154-163	aralkylamine N-acetyltransferase	Rattus norvegicus	74-80
10391916-12	1999	LAT-2 exhibits higher affinity (Km = 30-50 microM) to Tyr, Phe, Trp, Thr, Asn, Ile, Cys, Ser, Leu, Val, and Gln and relatively lower affinity (Km = 180-300 microM) to His, Ala, Met, and Gly.	Histidine	167-170	solute carrier family 7 member 8	Rattus norvegicus	0-5
10381378-9	1999	When a conserved histidine within the human SIRT2 sirtuin was converted to a tyrosine, the mutant recombinant protein was unable to transfer radioactivity from [32P]NAD to BSA.	Histidine	17-26	sirtuin 2	Homo sapiens	44-49
10424441-4	1999	To better understand the molecular interaction between KIR and TCR zeta-chain, we generated a His-tag fusion protein of a p70 KIR cytoplasmic tail (His-CytKIR) and used this protein to coprecipitate TCR zeta-chain from Jurkat T cells.	Histidine	148-151	CD247 molecule	Homo sapiens	63-77
10424441-4	1999	To better understand the molecular interaction between KIR and TCR zeta-chain, we generated a His-tag fusion protein of a p70 KIR cytoplasmic tail (His-CytKIR) and used this protein to coprecipitate TCR zeta-chain from Jurkat T cells.	Histidine	148-151	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	63-66
10424441-6	1999	Interestingly, the association between the His-CytKIR and TCR zeta was dependent on the phosphorylation of the His-CytKIR.	Histidine	43-46	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	58-61
10424441-6	1999	Interestingly, the association between the His-CytKIR and TCR zeta was dependent on the phosphorylation of the His-CytKIR.	Histidine	111-114	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	58-61
10350625-10	1999	For cholesterol esterase, carbamates 8-10 are more potent than carbamates S-2, 4, and 5 probably due to the fact that the inhibitor molecules interact with the second alkyl chain binding site of the enzyme through a hydrogen bond between the phenol hydroxy group of the inhibitor molecules and the His 435 residue in that site.	Histidine	298-301	carboxyl ester lipase	Homo sapiens	4-24
10350627-3	1999	The deduced amino acid sequence of CA-RP XI showed an overall similarity of 42-53% to the active site residues of other active CA isozymes; however, it lacked three zinc-binding histidine residues, raising questions regarding its CA catalytic activity.	Histidine	178-187	carbonic anhydrase 11	Homo sapiens	35-43
10397171-5	1999	The entire coding region of p40phox was shown to interact with TRX both in assays of histidine prototrophy and beta-galactosidase activity; in contrast, no interaction was observed with substituted mutant TRX (C32S/C35S), which lacks reducing activity.	Histidine	85-94	neutrophil cytosolic factor 4	Homo sapiens	28-35
10397171-5	1999	The entire coding region of p40phox was shown to interact with TRX both in assays of histidine prototrophy and beta-galactosidase activity; in contrast, no interaction was observed with substituted mutant TRX (C32S/C35S), which lacks reducing activity.	Histidine	85-94	thioredoxin	Homo sapiens	63-66
10233054-3	1999	A histidine at position 355 in the Kv1.1 channel protein (homologous to Shaker 425) was responsible for this pH-dependent reduction of TEA+ sensitivity, since the TEA+ effect became independent of pHo after chemical modification of the Kv1.1 channel at H355 and in the H355G and H355K mutant Kv1.1 channels.	Histidine	2-11	potassium voltage-gated channel subfamily A member 1	Homo sapiens	35-40
10233054-3	1999	A histidine at position 355 in the Kv1.1 channel protein (homologous to Shaker 425) was responsible for this pH-dependent reduction of TEA+ sensitivity, since the TEA+ effect became independent of pHo after chemical modification of the Kv1.1 channel at H355 and in the H355G and H355K mutant Kv1.1 channels.	Histidine	2-11	potassium voltage-gated channel subfamily A member 1	Homo sapiens	236-241
10233054-3	1999	A histidine at position 355 in the Kv1.1 channel protein (homologous to Shaker 425) was responsible for this pH-dependent reduction of TEA+ sensitivity, since the TEA+ effect became independent of pHo after chemical modification of the Kv1.1 channel at H355 and in the H355G and H355K mutant Kv1.1 channels.	Histidine	2-11	potassium voltage-gated channel subfamily A member 1	Homo sapiens	236-241
10385247-7	1999	Mutations of threonine 100 and arginine 102 at the extracellular side of transmembrane II of the guinea-pig 5-HT1D receptor to the corresponding primate residues, isoleucine and histidine, respectively, enhanced its affinity for isochromans to that of the gorilla receptor, with little effects on its affinities for serotonin, sumatriptan and metergoline.	Histidine	178-187	5-hydroxytryptamine receptor 1D	Cavia porcellus	108-123
10218494-2	1999	However, another form of GnRH of unknown function (pGlu-His-Trp-Ser-His-Gly-Trp-Tyr-Pro-Gly; GnRH-II) is expressed in the mesencephalon of all vertebrate classes except jawless fish.	Histidine	56-59	gonadotropin releasing hormone 1	Mus musculus	25-29
10218494-2	1999	However, another form of GnRH of unknown function (pGlu-His-Trp-Ser-His-Gly-Trp-Tyr-Pro-Gly; GnRH-II) is expressed in the mesencephalon of all vertebrate classes except jawless fish.	Histidine	56-59	gonadotropin releasing hormone 1	Mus musculus	93-97
10350163-0	1999	Histamine H3 receptor binding sites in rat cortex following L-histidine loading.	Histidine	60-71	histamine receptor H3	Rattus norvegicus	0-21
10051442-6	1999	MET8 was further cloned into pET14b to allow expression of the protein with an N-terminal His-tag.	Histidine	90-93	bifunctional precorrin-2 dehydrogenase/sirohydrochlorin ferrochelatase MET8	Saccharomyces cerevisiae S288C	0-4
10037691-4	1999	IIABMan transfers phosphoryl groups from the phospho-histidine-containing phospho-carrier protein of the PTS to His-10 on IIA, hence to His-175 on IIB, and finally to the 6"-OH of the transported hexose.	Histidine	53-62	colicin Ia immunity protein	Escherichia coli	0-3
10037691-4	1999	IIABMan transfers phosphoryl groups from the phospho-histidine-containing phospho-carrier protein of the PTS to His-10 on IIA, hence to His-175 on IIB, and finally to the 6"-OH of the transported hexose.	Histidine	112-115	colicin Ia immunity protein	Escherichia coli	0-3
10037691-4	1999	IIABMan transfers phosphoryl groups from the phospho-histidine-containing phospho-carrier protein of the PTS to His-10 on IIA, hence to His-175 on IIB, and finally to the 6"-OH of the transported hexose.	Histidine	136-139	colicin Ia immunity protein	Escherichia coli	0-3
10022850-5	1999	Zta bound directly to two related cysteine- and histidine-rich domains of CBP, referred to as C/H1 and C/H3.	Histidine	48-57	SUN domain containing ossification factor	Homo sapiens	94-107
10081961-3	1999	While a hydrophobic residue is found at position 21 in most of the KH modules, a buried His is conserved in all the 15 KH repeats of vigilin.	Histidine	88-91	high density lipoprotein binding protein	Homo sapiens	133-140
10081961-6	1999	ii) can we define the interactions that allow a conserved buried position to be occupied by a histidine both in vig-KH6 and in the whole vigilin KH sub-family?	Histidine	94-103	high density lipoprotein binding protein	Homo sapiens	137-144
10024463-6	1999	Recombinant P5, with an N terminal extension of 10 residues that included six histidines, was cloned and expressed in Escherichia coli.	Histidine	78-88	protein disulfide isomerase family A, member 6	Rattus norvegicus	12-14
10089421-2	1999	Recent biochemical studies have shown that SixA is involved in the signal transduction of the His-Asp phosphorelay through the dephosphorylation of the histidine-containing phosphotransfer (HPt) domain of the anaerobic sensor kinase ArcB.	Histidine	94-97	hypothetical protein	Escherichia coli	233-237
10089421-2	1999	Recent biochemical studies have shown that SixA is involved in the signal transduction of the His-Asp phosphorelay through the dephosphorylation of the histidine-containing phosphotransfer (HPt) domain of the anaerobic sensor kinase ArcB.	Histidine	152-161	hypothetical protein	Escherichia coli	233-237
10780478-3	1999	Here, we found that other mature tRNAs of Drosophila were also hyperprocessed by M1 RNA in vitro and that some of such tRNAs were probably alanine and histidine tRNAs.	Histidine	151-160	transfer RNA:Serine-AGA 3-1	Drosophila melanogaster	33-38
10780478-3	1999	Here, we found that other mature tRNAs of Drosophila were also hyperprocessed by M1 RNA in vitro and that some of such tRNAs were probably alanine and histidine tRNAs.	Histidine	151-160	transfer RNA:Serine-AGA 3-1	Drosophila melanogaster	119-124
10780478-3	1999	Here, we found that other mature tRNAs of Drosophila were also hyperprocessed by M1 RNA in vitro and that some of such tRNAs were probably alanine and histidine tRNAs.	Histidine	151-160	transfer RNA:Serine-AGA 3-1	Drosophila melanogaster	119-124
9830034-2	1998	Under those conditions, the tripartite sensor kinase ArcB undergoes autophosphorylation at the expense of ATP and subsequently transphosphorylates its cognate response regulator ArcA through a His --&gt; Asp --&gt; His --&gt; Asp phosphorelay pathway.	Histidine	193-196	hypothetical protein	Escherichia coli	53-57
9830034-2	1998	Under those conditions, the tripartite sensor kinase ArcB undergoes autophosphorylation at the expense of ATP and subsequently transphosphorylates its cognate response regulator ArcA through a His --&gt; Asp --&gt; His --&gt; Asp phosphorelay pathway.	Histidine	215-218	hypothetical protein	Escherichia coli	53-57
9830034-5	1998	This reverse phosphorelay involves both the conserved His-717 of the secondary transmitter domain and the conserved Asp-576 of the receiver domain of ArcB but not the conserved His-292 of its primary transmitter domain.	Histidine	54-57	hypothetical protein	Escherichia coli	150-154
9826622-4	1998	We expressed histidine-tagged rat cardiac myosin motor domains along with rat ventricular light chain 1 in mammalian COS cells.	Histidine	13-22	myosin heavy chain 14	Homo sapiens	42-48
9792674-0	1998	Lysine 58 and histidine 66 at the C-terminal alpha-helix of monocyte chemoattractant protein-1 are essential for glycosaminoglycan binding.	Histidine	14-23	C-C motif chemokine ligand 2	Homo sapiens	60-94
9792674-4	1998	We substituted lysine or histidine residues at the C-terminal end of MCP-1 with alanine residues and tested these mutants for their ability to bind heparin, heparan sulfate, hyaluronic acid, and chondroitin sulfate-C.	Histidine	25-34	C-C motif chemokine ligand 2	Homo sapiens	69-74
9792674-9	1998	Therefore, we conclude that the Lys-58 and His-66 residues in the C-terminal alpha-helix of MCP-1 are essential for glycosaminoglycan binding and probably for the binding to the endothelial surface proteoglycans.	Histidine	43-46	C-C motif chemokine ligand 2	Homo sapiens	92-97
9771897-0	1998	An Arabidopsis protein that interacts with the cytokinin-inducible response regulator, ARR4, implicated in the His-Asp phosphorylay signal transduction.	Histidine	111-114	response regulator 4	Arabidopsis thaliana	87-91
9790586-2	1998	The mutation was found to be located in HIP1, a gene known to encode a high-affinity permease for histidine.	Histidine	98-107	histidine permease	Saccharomyces cerevisiae S288C	40-44
9683496-0	1998	A dual-signaling mechanism mediated by the ArcB hybrid sensor kinase containing the histidine-containing phosphotransfer domain in Escherichia coli.	Histidine	84-93	hypothetical protein	Escherichia coli	43-47
9683496-2	1998	ArcB is a hybrid sensor kinase having multiple phosphorylation sites in its primary amino acid sequence, including a transmitter, a receiver, and a histidine-containing phosphotransfer (HPt) domain.	Histidine	148-157	hypothetical protein	Escherichia coli	0-4
9683496-4	1998	Results of recent in vitro studies revealed multistep His-to-Asp phosphotransfer circuitry in the ArcB-ArcA signaling system.	Histidine	54-57	hypothetical protein	Escherichia coli	98-102
9683496-6	1998	The results suggested that the phosphorylated His-717 site in the HPt domain of ArcB is essential for anaerobic repression of sdh.	Histidine	46-49	hypothetical protein	Escherichia coli	80-84
9683496-7	1998	Nonetheless, the ArcB mutant lacking this crucial His-717 site does not necessarily exhibit a null phenotype with respect to ArcB-ArcA signaling.	Histidine	50-53	hypothetical protein	Escherichia coli	17-21
9685739-0	1998	The structure and function of the histidine-containing phosphotransfer (HPt) signaling domain of the Escherichia coli ArcB sensor.	Histidine	34-43	hypothetical protein	Escherichia coli	118-122
9685739-2	1998	ArcB is an unorthodox His-kinase, in that it contains three types of phosphotransfer signaling domains in its primary amino acid sequence, namely, transmitter (or His-kinase), receiver, and histidine-containing phosphotransfer (HPt) domains.	Histidine	190-199	hypothetical protein	Escherichia coli	0-4
9582326-10	1998	In contrast, complex p38.p37.p36-his displayed no ATPase, suggesting that p40 is essential for ATPase activity.	Histidine	33-36	annexin A2	Homo sapiens	29-32
9582326-12	1998	p36 complex was more salt-resistant than that of the p40-his.p37.p36 complex.	Histidine	57-60	annexin A2	Homo sapiens	65-68
9553063-11	1998	Depletion of histidine-tagged CRK3 from L. mexicana cell extracts, by Ni-nitrilotriacetic acid agarose selection, reduced histone H1 kinase activity binding to p13(suc1).	Histidine	13-22	H3 histone pseudogene 6	Homo sapiens	160-163
9553063-13	1998	SBCRK and histidine-tagged CRK3 activities were inhibited by the purine analogue olomoucine with an IC50 of 28 and 42 microM, respectively, 5-6-fold higher than human p34(cdc2)/cyclinB.	Histidine	10-19	cyclin dependent kinase 1	Homo sapiens	171-175
9512488-0	1998	Mutational analysis of histidine residues in the rabbit Na+/dicarboxylate co-transporter NaDC-1.	Histidine	23-32	solute carrier family 13 member 2	Oryctolagus cuniculus	89-95
9512488-2	1998	Therefore the role of histidine residues in the function of NaDC-1 was examined by site-directed mutagenesis.	Histidine	22-31	solute carrier family 13 member 2	Oryctolagus cuniculus	60-66
9512488-3	1998	All 11 histidine residues in NaDC-1 were converted to alanine, but only mutant H106A exhibited a decrease in succinate transport.	Histidine	7-16	solute carrier family 13 member 2	Oryctolagus cuniculus	29-35
9512488-4	1998	Additional mutations of NaDC-1 at position 106 showed that aspartic acid and asparagine, but not arginine, can substitute for histidine.	Histidine	126-135	solute carrier family 13 member 2	Oryctolagus cuniculus	24-30
9521770-3	1998	There are four conserved histidine residues in the heme binding region of sGC.	Histidine	25-34	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	74-77
9521770-5	1998	Site-directed mutagenesis was used to individually change each of the conserved histidines in sGC beta1(1-385) to alanine or glycine, and the resulting mutants were expressed in E. coli.	Histidine	80-90	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	94-97
9482873-4	1998	Comparison of the GliPR model with the P14a structure lead to the identification of a common partially solvent-exposed spatial cluster of four amino acid residues, His-69, Glu-88, Glu-110, and His-127 in the GliPR numeration.	Histidine	164-167	pathogenesis-related leaf protein 6	Solanum lycopersicum	39-43
9482873-4	1998	Comparison of the GliPR model with the P14a structure lead to the identification of a common partially solvent-exposed spatial cluster of four amino acid residues, His-69, Glu-88, Glu-110, and His-127 in the GliPR numeration.	Histidine	193-196	pathogenesis-related leaf protein 6	Solanum lycopersicum	39-43
9425044-2	1998	By placing a His near the oxyanion hole of human butyrylcholinesterase (BChE), we made an esterase (G117H) that catalyzed the hydrolysis of several OP, including sarin and VX [Millard et al.	Histidine	13-16	butyrylcholinesterase	Homo sapiens	49-70
9425044-2	1998	By placing a His near the oxyanion hole of human butyrylcholinesterase (BChE), we made an esterase (G117H) that catalyzed the hydrolysis of several OP, including sarin and VX [Millard et al.	Histidine	13-16	butyrylcholinesterase	Homo sapiens	72-76
9438388-4	1998	A soluble VEGF receptor was constructed by fusing the entire extracellular domain of murine flk-1 to a six-histidine tag at the COOH terminus (ExFlk.6His).	Histidine	107-116	vascular endothelial growth factor A	Rattus norvegicus	10-14
9450689-0	1997	An active-site histidine of NR1/2C mediates voltage-independent inhibition by zinc.	Histidine	15-24	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	28-31
9450689-6	1997	Reduction of zinc inhibition of NR1/2C heteromers was seen after labeling with the histidine-modifying reagent diethylpyrocarbonate.	Histidine	83-92	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	32-35
9450689-7	1997	This finding suggests that the NR1/2C heteromeric ion channel contains an active-site histidine responsible for zinc inhibition.	Histidine	86-95	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	31-34
9414554-5	1997	Analysis of the tryptic digestion products of the iodoacetate-modified S-RNase by reversed-phase high-performance liquid chromatography and electrospray-ionization mass spectrometry showed that histidine-32 was preferentially modified in the absence of 3"-GMP.	Histidine	194-203	GDP-mannose pyrophosphorylase	Solanum lycopersicum	256-259
9364964-5	1997	Furthermore, this complex can be reconstituted in vitro by adding recombinant STI1 containing an amino-terminal histidine tag to promastigote lysate and subsequent purification using metal chelate affinity chromatography.	Histidine	112-121	Hsp90 cochaperone STI1	Saccharomyces cerevisiae S288C	78-82
9379177-4	1997	Binding investigations on the natural substrates SCN- and I-, at varying pH and temperature, showed that their interaction with lactoperoxidase involves the protonation of a common site in proximity of the iron (possibly distal histidine).	Histidine	228-237	lactoperoxidase	Bos taurus	128-143
9272156-3	1997	We observed a novel germline mutation in the hMLH1 gene (His--&gt;Pro at codon 329) in an HNPCC family.	Histidine	57-60	mutL homolog 1	Homo sapiens	45-50
9268342-7	1997	Furthermore, the predicted secondary structure of LysoPLA I resembles that of the alpha/beta-hydrolase fold, with Ser-119, Asp-174, and His-208 occupying the conserved topological location of the catalytic triad in the alpha/beta-hydrolases.	Histidine	136-139	lysophospholipase 1	Mus musculus	50-59
9256341-2	1997	We demonstrated previously that individuals affected with an autosomal dominant disorder of skull morphogenesis (craniosynostosis, Boston type) bear a mutated form of Msx2 in which a histidine is substituted for a highly conserved proline in position 7 of the N-terminal arm of the homeodomain (p148h).	Histidine	183-192	msh homeobox 2	Rattus norvegicus	167-171
9200711-1	1997	Histidine-235 of human 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) lyase is the second basic residue in a conserved HXH motif.	Histidine	0-9	3-hydroxy-3-methylglutaryl-CoA lyase	Homo sapiens	23-69
9166854-7	1997	In a Northern blot analysis from homogeneous tissue biopsy from the intradermal injection sites, RANTES was more potent than MCP-1 in increasing histidine decarboxylase (HDC) mRNA, the sole enzyme responsible for the production of histamine from histidine.	Histidine	145-154	C-C motif chemokine ligand 2	Rattus norvegicus	125-130
23297402-2	2013	Although it is believed that at low pH, the His-E7 gate is in its open conformation, the full relationship between the His-E7 protonation state, its conformation, and ligand migration in Mb is hotly debated.	Histidine	44-47	myoglobin	Homo sapiens	187-189
23297402-2	2013	Although it is believed that at low pH, the His-E7 gate is in its open conformation, the full relationship between the His-E7 protonation state, its conformation, and ligand migration in Mb is hotly debated.	Histidine	119-122	myoglobin	Homo sapiens	187-189
23002992-7	2013	The DmCBS heme bears histidine and cysteine axial ligands, and the enzyme becomes inactive when the cysteine ligand is replaced.	Histidine	21-30	Cystathionine beta-synthase	Drosophila melanogaster	4-9
23685414-2	2013	Since this mutation is expected to change amino acid coding from histidine to tyrosine and cause an altered insulin receptor substrate-4 protein, and the insulin receptor substrate-4 protein may be involved in neuronal growth and function in the brain, it is possible that it is this insulin receptor substrate-4 gene mutation that underlies this patient"s schizophrenia development.	Histidine	65-74	insulin receptor substrate 4	Homo sapiens	108-136
22974464-5	2013	Our data indicate that the cysteine-histidine-rich (CH) and helicase domains of UPF1 are only essential for the early steps of NMD, whereas the heavily phosphorylated N- and C-terminal regions play a redundant but essential role in the target transcript degradation steps of NMD.	Histidine	36-45	UPF1 RNA helicase and ATPase	Homo sapiens	80-84
22906720-0	2012	A role for His-160 in peroxide inhibition of S. cerevisiae S-formylglutathione hydrolase: evidence for an oxidation sensitive motif.	Histidine	11-14	S-formylglutathione hydrolase	Saccharomyces cerevisiae S288C	59-88
22739622-7	2012	Since repeated administration of L-histidine (a precursor of histamine) to Wt mice also showed the same effects, our observations suggested that OCT3 is the molecule responsible for clearance of ischemia-induced histamine in the brain and targeted disruption of Oct3 ameliorated ischemic brain damage through an increase in regulatory T cells.	Histidine	33-44	solute carrier family 22 (organic cation transporter), member 3	Mus musculus	145-149
22632602-1	2012	The proximal cavity mutant of myoglobin consists of a mutation of the proximal histidine to glycine (H93G), which permits exogenous ligands to bind to the heme iron.	Histidine	79-88	myoglobin	Homo sapiens	30-39
22187146-5	2012	First, the N-terminal 6 x His-tag of the single-chain relaxin-3 precursor was removed by Aeromonas aminopeptidase and all of the primary amines of the resultant peptide were reversibly blocked by citroconic anhydride.	Histidine	26-29	relaxin 3	Homo sapiens	54-63
22773562-4	2012	Chloramines of taurine and histidine caused slight damage to PCNA in cells.	Histidine	27-36	proliferating cell nuclear antigen	Homo sapiens	61-65
22451660-7	2012	Each of the six FAD2 substitutions was individually converted back to the FADX equivalent identifying residues 111 and 115, adjacent to the first histidine box, as key determinants of conjugase product partitioning.	Histidine	146-155	fatty acid desaturase 2	Arabidopsis thaliana	16-20
22451665-3	2012	Utilizing biophysical and biochemical methods, we characterized two independent domains, Ala-35-Lys-124 and His-291-Gly-382, on the TRPM3 N terminus, responsible for interactions with the Ca(2+)-binding proteins calmodulin (CaM) and S100A1.	Histidine	108-111	transient receptor potential cation channel subfamily M member 3	Homo sapiens	132-137
2611202-1	1989	The kinetics of carbon monoxide (CO) binding to myoglobin (Mb) modified at the distal histidine (His) by cyanogen bromide (BrCN) has been studied.	Histidine	86-95	myoglobin	Homo sapiens	48-57
9162080-9	1997	Within the catalytic domain, the essential Asp, His, and Ser residues that conform the catalytic triad of this family of proteases are conserved in P69B.	Histidine	48-51	subtilisin-like protease	Solanum lycopersicum	148-152
2611202-1	1989	The kinetics of carbon monoxide (CO) binding to myoglobin (Mb) modified at the distal histidine (His) by cyanogen bromide (BrCN) has been studied.	Histidine	97-100	myoglobin	Homo sapiens	48-57
22529353-0	2012	Histidine pairing at the metal transport site of mammalian ZnT transporters controls Zn2+ over Cd2+ selectivity.	Histidine	0-9	CD2 molecule	Homo sapiens	95-98
2775230-5	1989	The differences are tentatively ascribed to ionization of the proximal histidine ligand in alkaline myoglobin peroxide.	Histidine	71-80	myoglobin	Homo sapiens	100-109
22441676-3	2012	In the present study, we developed a transgenic mouse (designated H60H Tg) expressing a variant of H60, designated H60H, in which the arginine residue at position 4 of the H60 epitope sequence (LTFNYRNL) is replaced by a histidine residue (LTFHYRNL).	Histidine	221-230	histocompatibility 60a	Mus musculus	99-102
9171884-5	1997	The peptide Ac-Nle-c[Asp-His-Phe-Arg-D-Trp9-Ala-Lys]-NH2 demonstrated the greatest differentiation in binding affinity between the hMC1R and hMC4R (78-fold).	Histidine	25-28	melanocortin 1 receptor	Homo sapiens	131-146
9150409-6	1997	In addition, a dramatic change in the catalytic activity was observed when the histidine residue (27d) in the CDR1 light chain was replaced with alanine.	Histidine	79-88	cerebellar degeneration related protein 1	Homo sapiens	110-114
2570065-0	1989	Site-specific mutagenesis of lysine-204, tyrosine-224, tyrosine-228, and histidine-307 of porcine kidney D-amino acid oxidase and the implications as to its catalytic function.	Histidine	73-82	D-amino acid oxidase	Homo sapiens	105-125
9036967-6	1997	Thus, in addition to the previously defined role of 1253 in the FcRn-IgG interaction, these histidines play a key role in mediating the functions conducted by this Fc receptor.	Histidine	92-102	Fc receptor	Mus musculus	164-175
9164465-0	1997	Crystal structures of HINT demonstrate that histidine triad proteins are GalT-related nucleotide-binding proteins.	Histidine	44-53	adenosine 5'-monophosphoramidase HINT1	Oryctolagus cuniculus	22-26
9164465-1	1997	Histidine triad nucleotide-binding protein (HINT), a dimeric purine nucleotide-binding protein from rabbit heart, is a member of the HIT (histidine triad) superfamily which includes HINT homologues and FHIT (HIT protein encoded at the chromosome 3 fragile site) homologues.	Histidine	138-147	adenosine 5'-monophosphoramidase HINT1	Oryctolagus cuniculus	0-42
2570065-1	1989	In order to evaluate the possible contributions of Lys-204, Tyr-224, Tyr-228, and His-307 in porcine kidney D-amino acid oxidase [EC 1.4.3.3] (DAO) to its catalytic function, we constructed four point mutant cDNAs encoding enzymes possessing Glu-204, Phe-224, Phe-228, and Leu-307 by oligonucleotide-directed in vitro mutagenesis.	Histidine	82-85	D-amino acid oxidase	Homo sapiens	108-128
9164465-1	1997	Histidine triad nucleotide-binding protein (HINT), a dimeric purine nucleotide-binding protein from rabbit heart, is a member of the HIT (histidine triad) superfamily which includes HINT homologues and FHIT (HIT protein encoded at the chromosome 3 fragile site) homologues.	Histidine	138-147	adenosine 5'-monophosphoramidase HINT1	Oryctolagus cuniculus	44-48
9164465-1	1997	Histidine triad nucleotide-binding protein (HINT), a dimeric purine nucleotide-binding protein from rabbit heart, is a member of the HIT (histidine triad) superfamily which includes HINT homologues and FHIT (HIT protein encoded at the chromosome 3 fragile site) homologues.	Histidine	138-147	adenosine 5'-monophosphoramidase HINT1	Oryctolagus cuniculus	182-186
21983886-9	2012	In conclusion, individuals with EPHX1 113His/His slow activity genotype may not detoxify reactive carcinogenic epoxides efficiently, binding of reactive epoxides to DNA cause DNA damage.	Histidine	41-44	epoxide hydrolase 1	Homo sapiens	32-37
22034099-8	2012	In an analysis involving recombinant His-DDX3 and His-DDX5, PP2A pretreatment of His-DDX5 increased the interaction with endogenous DDX3, and vice versa.	Histidine	37-40	protein phosphatase 2 phosphatase activator	Homo sapiens	60-64
2570348-3	1989	beta-Galactosidase and glutamine synthetase expression in chromosomally integrated GLN1-lacZ fusion strains were co-regulated in response to a shift from glutamine to glutamate as the nitrogen source, purine limitation, and 3-aminotriazole-induced histidine starvation.	Histidine	248-257	glutamate--ammonia ligase	Saccharomyces cerevisiae S288C	83-87
22034099-8	2012	In an analysis involving recombinant His-DDX3 and His-DDX5, PP2A pretreatment of His-DDX5 increased the interaction with endogenous DDX3, and vice versa.	Histidine	37-40	DEAD-box helicase 5	Homo sapiens	85-89
22034099-8	2012	In an analysis involving recombinant His-DDX3 and His-DDX5, PP2A pretreatment of His-DDX5 increased the interaction with endogenous DDX3, and vice versa.	Histidine	50-53	DEAD-box helicase 5	Homo sapiens	54-58
22034099-8	2012	In an analysis involving recombinant His-DDX3 and His-DDX5, PP2A pretreatment of His-DDX5 increased the interaction with endogenous DDX3, and vice versa.	Histidine	50-53	protein phosphatase 2 phosphatase activator	Homo sapiens	60-64
22034099-8	2012	In an analysis involving recombinant His-DDX3 and His-DDX5, PP2A pretreatment of His-DDX5 increased the interaction with endogenous DDX3, and vice versa.	Histidine	50-53	DEAD-box helicase 5	Homo sapiens	85-89
22034099-8	2012	In an analysis involving recombinant His-DDX3 and His-DDX5, PP2A pretreatment of His-DDX5 increased the interaction with endogenous DDX3, and vice versa.	Histidine	50-53	DEAD-box helicase 5	Homo sapiens	54-58
22034099-8	2012	In an analysis involving recombinant His-DDX3 and His-DDX5, PP2A pretreatment of His-DDX5 increased the interaction with endogenous DDX3, and vice versa.	Histidine	50-53	protein phosphatase 2 phosphatase activator	Homo sapiens	60-64
8954946-2	1996	Using histidine-tagged TBP as a ligand for affinity-purification of proteins bound to TBP, we purified a 120-kD protein, termed TBP-interacting protein 120 (TIP120), from rat liver nuclear extracts.	Histidine	6-15	TATA box binding protein	Rattus norvegicus	23-26
8954946-2	1996	Using histidine-tagged TBP as a ligand for affinity-purification of proteins bound to TBP, we purified a 120-kD protein, termed TBP-interacting protein 120 (TIP120), from rat liver nuclear extracts.	Histidine	6-15	TATA box binding protein	Rattus norvegicus	86-89
8962082-12	1996	Both the MBP and the thioredoxin-His-tags do not appear to interfere with the catalytic activity of human FAS or its partial activities.	Histidine	33-36	thioredoxin	Homo sapiens	21-32
8962099-5	1996	mCPEB shows 80% overall identity with its Xenopus counterpart, with a higher homology in the carboxyl-terminal portion, which contains two RNA recognition motifs and a cysteine/histidine repeat.	Histidine	177-186	cytoplasmic polyadenylation element binding protein 1	Mus musculus	0-5
22034099-8	2012	In an analysis involving recombinant His-DDX3 and His-DDX5, PP2A pretreatment of His-DDX5 increased the interaction with endogenous DDX3, and vice versa.	Histidine	50-53	DEAD-box helicase 5	Homo sapiens	85-89
2566116-4	1989	This mutation converts the 340th amino acid of NADH dehydrogenase subunit 4 from an arginine to a histidine and eliminates an SfaNI endonuclease restriction site.	Histidine	98-107	mitochondrially encoded NADH dehydrogenase 4	Homo sapiens	47-75
22170566-3	2012	Using the structure of a complex between the C-terminus of SNAP25 and BoNT/A-LC as a model to design SNAP25-derived pseudosubstrate inhibitors (SNAPIs) that prevent presentation of the scissile bond to the active site, we introduced multiple His residues to replace Ala-Asn-Gln-Arg (residues 195-198) at the substrate cleavage site, with the intent to identify possible side-chain interactions with the active site Zn.	Histidine	242-245	synaptosome associated protein 25	Homo sapiens	59-65
9050160-1	1996	113Cd NMR spectroscopy in both the solution and solid state has been used to investigate the role of the metal ion and the proximal histidine on metalloporphyrin reorientation in myoglobin.	Histidine	132-141	myoglobin	Homo sapiens	179-188
22170566-3	2012	Using the structure of a complex between the C-terminus of SNAP25 and BoNT/A-LC as a model to design SNAP25-derived pseudosubstrate inhibitors (SNAPIs) that prevent presentation of the scissile bond to the active site, we introduced multiple His residues to replace Ala-Asn-Gln-Arg (residues 195-198) at the substrate cleavage site, with the intent to identify possible side-chain interactions with the active site Zn.	Histidine	242-245	synaptosome associated protein 25	Homo sapiens	101-107
2765496-9	1989	The LPL hydrolysis reaction is base catalyzed, exhibiting two pKa values; the more acidic of these is 6.5, consistent with base catalysis by histidine.	Histidine	141-150	lipoprotein lipase	Homo sapiens	4-7
8947475-3	1996	The C-terminus (His-Lys-Met) of trihydroxycoprostanoyl-CoA oxidase did not seem to interact with the C-terminal peroxisomal targeting signal 1 (PTS1) import receptor, although the tripeptide fits the rule of conserved PTS1 variants for targeting of proteins to glycosomes of Trypanosomatidae.	Histidine	16-19	acyl-CoA oxidase 2	Rattus norvegicus	32-66
2650908-3	1989	Using oligonucleotide probes we have shown that the N-ras gene is activated by a point mutation at the third base of codon 61 resulting in the substitution of histidine for glutamine in the p21 ras gene product.	Histidine	159-168	HRas proto-oncogene, GTPase	Homo sapiens	190-197
8810323-7	1996	Greater than two-thirds of GRP-1 are only two amino acids, namely glutamine (50%) and histidine (18%).	Histidine	86-95	glutamine repeat protein 1	Mus musculus	27-32
2707256-3	1989	These non-functional EF-2s with replacements of the histidine-715 residue showed various extents of inhibition of protein synthesis by competing with functional EF-2 in vivo.	Histidine	52-61	eukaryotic translation elongation factor 2	Mus musculus	21-25
8931940-2	1996	A novel artificial peptide named HPH-Pep, comprising a pyridine and two histidine units, was synthesized.	Histidine	72-81	progestagen associated endometrial protein	Homo sapiens	37-40
22590679-5	2012	However, when dialyzed together with Gst-gp3 or with Gst-gp4, His-gp2b and His-gp4 remain soluble and oligomers are obtained by affinity-chromatography.	Histidine	62-65	CD36 molecule	Homo sapiens	57-60
21310790-7	2012	Moreover, mutation of a conserved histidine in the NACHT domain also has contrasting effects on NOD1 and NOD2 mediated NF-kappaB activation.	Histidine	34-43	nucleotide binding oligomerization domain containing 1	Homo sapiens	96-100
2707256-4	1989	These results suggest that histidine-715 is essential for the translocase activity of EF-2 and that the region around diphthamide functions in recognition of, and/or binding to ribosomes.	Histidine	27-36	eukaryotic translation elongation factor 2	Mus musculus	86-90
2919172-5	1989	Cucumber ascorbate oxidase contained four histidine-rich regions with striking sequence homology to the corresponding parts of the other multicopper oxidases such as Neurospora crassa laccase and human ceruloplasmin and, to some extent, to a low molecular weight copper protein such as plastocyanin.	Histidine	42-51	L-ascorbate oxidase	Cucumis sativus	9-26
22139846-6	2012	Expression of HvMTP1/AtMTP1 chimeras in yeast revealed a five-residue sequence within the AtMTP1 N-segment of the His-rich intracytoplasmic loop that confines specificity to Zn(2+).	Histidine	114-117	zinc transporter	Arabidopsis thaliana	21-27
22139846-6	2012	Expression of HvMTP1/AtMTP1 chimeras in yeast revealed a five-residue sequence within the AtMTP1 N-segment of the His-rich intracytoplasmic loop that confines specificity to Zn(2+).	Histidine	114-117	zinc transporter	Arabidopsis thaliana	90-96
8836129-0	1996	Histidine residues in rabbit liver microsomal cytochrome P-450 2B4 control electron transfer from NADPH-cytochrome P-450 reductase and cytochrome b5.	Histidine	0-9	cytochrome P450 2B4	Oryctolagus cuniculus	46-66
8836129-1	1996	Treatment of cytochrome P-450 2B4 (P-450 2B4) with diethylpyrocarbonate to introduce 10-11 equivalents of acylating agent per polypeptide chain resulted in the selective derivatization of histidine residues characterized by differential susceptibility toward the modifier.	Histidine	188-197	cytochrome P450 2B4	Oryctolagus cuniculus	13-33
8755573-3	1996	FGFR2/Neu chimeras were generated by substituting the extracellular domain of Neu with that of FGFR2 containing the following Crouzon mutations: Tyr-340--&gt;His; Cys-342--&gt;Tyr; Cys-342--&gt;Arg; Cys-342--&gt;Ser; Ser-354--&gt;Cys: and delta17 (deletion of amino acids 345-361).	Histidine	158-161	fibroblast growth factor receptor 2	Homo sapiens	0-5
2919172-5	1989	Cucumber ascorbate oxidase contained four histidine-rich regions with striking sequence homology to the corresponding parts of the other multicopper oxidases such as Neurospora crassa laccase and human ceruloplasmin and, to some extent, to a low molecular weight copper protein such as plastocyanin.	Histidine	42-51	ceruloplasmin	Homo sapiens	202-215
22076863-0	2012	Histidine affinity tags affect MSP1(42)  structural stability and immunodominance in mice.	Histidine	0-9	salivary protein electrophoretic 1, regulator	Mus musculus	31-35
2560194-1	1989	Semisynthesis has been employed to replace the axial methionine in horse heart cytochrome c with histidine.	Histidine	97-106	cytochrome c, somatic	Equus caballus	79-91
22553750-4	2012	RESULTS: Mutational analysis of mtDNA in these two Chinese pedigrees revealed one common LHON-associated mutation, G11778A (Arg His), in the MT-ND4 gene.	Histidine	128-131	mitochondrially encoded NADH dehydrogenase 4	Homo sapiens	141-147
8694771-16	1996	The (beta 1-3)GalT activity was also inhibited by diethyl pyrocarbonate, but not by N-ethylmaleimide or iodoacetamide, suggesting that active-site histidine residues, rather than cysteine residue(s), are important for enzyme activity.	Histidine	147-156	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	5-13
3042777-2	1988	The inactivation of elongation factor 2 (EF-2) by diphtheria toxin requires the presence of a post-translationally modified histidine residue in EF-2.	Histidine	124-133	elongation factor 2	Saccharomyces cerevisiae S288C	20-39
9373320-13	1996	However, when expressed together with the consensus motif His-Arg, as in HRWWXXXX or in HRXKWWXX, binding of these peptides to Fab 2925 increased as compared to peptides expressing the His-Arg motif only.	Histidine	58-61	FA complementation group B	Homo sapiens	127-130
22056627-3	2012	The substitution of arginine to histidine (R279H), due to a c.836G&gt;A mutation in exon 7 of the p63 gene, represents 55% of the identified mutations and is considered a mutational hot spot.	Histidine	32-41	tumor protein p63	Homo sapiens	98-101
3042777-2	1988	The inactivation of elongation factor 2 (EF-2) by diphtheria toxin requires the presence of a post-translationally modified histidine residue in EF-2.	Histidine	124-133	elongation factor 2	Saccharomyces cerevisiae S288C	41-45
8662772-5	1996	Using a degenerate phosphopeptide library screen, we show that the PTB domain of ShcC preferentially binds the sequence His-hydrophobic-Asn/hydrophobic-Asn-Pro-Ser/Thr-Tyr(P).	Histidine	120-123	SHC adaptor protein 3	Homo sapiens	81-85
3042777-2	1988	The inactivation of elongation factor 2 (EF-2) by diphtheria toxin requires the presence of a post-translationally modified histidine residue in EF-2.	Histidine	124-133	elongation factor 2	Saccharomyces cerevisiae S288C	145-149
2839508-2	1988	While each isozyme is encoded by the same structural gene, they differ by the amino acid sequence at the COOH-terminal end, with GPDH-3 having the sequence Asn-His-Pro-Glu-His-Met-COOH and with GPDH-1 extended by the three amino acid sequence Glu-Asn-Leu-COOH.	Histidine	160-163	uncharacterized protein	Drosophila melanogaster	129-135
8809190-1	1996	Using photoaffinity labeling with the progesterone analogue, progesterone-11 alpha-hemisuccinate-(2-[125I]-iodohistamine) ([125I]-his-PG), we identified and characterized a protein band of MW 29 kDa (p29) in mouse cerebellar membranes whose labeling is markedly inhibited by estrogens.	Histidine	111-114	SYF2 homolog, RNA splicing factor (S. cerevisiae)	Mus musculus	200-203
8638712-8	1996	We concluded that gastrin, acting through "gastrin/CCK-B type" receptors coupled to PTX-sensitive G protein, exerts a short-term regulation of histamine synthesis in gastric ECL cells by increasing both the affinity of HDC for L-histidine and the number of active enzyme molecules.	Histidine	227-238	histidine decarboxylase	Oryctolagus cuniculus	219-222
8617783-3	1996	The combined effect of two histidine mutants, E30H and Q62H, gave thioredoxin the capacity to bind to nickel ions immobilized on iminodiacetic acid- and nitrilotriacetic acid-Sepharose resins.	Histidine	27-36	thioredoxin	Homo sapiens	66-77
8617783-4	1996	Even though these two histidines were more than 30 residues apart in thioredoxin"s primary sequence, they were found to satisfy the geometric constraints for metal ion coordination as a result of the thioredoxin tertiary fold.	Histidine	22-32	thioredoxin	Homo sapiens	69-80
22161108-7	2011	As Bmh and Amh contain anti-HI in sera, great attention should be paid to avoid adverse reaction of blood transfusion in clinics.	Histidine	28-30	anti-Mullerian hormone	Homo sapiens	11-14
22026475-4	2011	In previous work, we showed that the kinetics of formation of a His73-heme alkaline conformer of yeast iso-1-cytochrome c requires ionization of the histidine ligand (pK(HL) ~ 6.5).	Histidine	149-158	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	103-108
8617783-4	1996	Even though these two histidines were more than 30 residues apart in thioredoxin"s primary sequence, they were found to satisfy the geometric constraints for metal ion coordination as a result of the thioredoxin tertiary fold.	Histidine	22-32	thioredoxin	Homo sapiens	200-211
2839508-2	1988	While each isozyme is encoded by the same structural gene, they differ by the amino acid sequence at the COOH-terminal end, with GPDH-3 having the sequence Asn-His-Pro-Glu-His-Met-COOH and with GPDH-1 extended by the three amino acid sequence Glu-Asn-Leu-COOH.	Histidine	172-175	uncharacterized protein	Drosophila melanogaster	129-135
8617783-5	1996	A third histidine mutation, S1H, provided additional metal ion chelation affinity, but the native histidine at position 6 of thioredoxin was found not to participate in binding.	Histidine	98-107	thioredoxin	Homo sapiens	125-136
8617783-6	1996	All of the histidine mutants exhibited decreased thermal stability as compared with wild-type thioredoxin; however, the introduction of an additional mutation, D26A, increased their melting temperatures beyond that of wild-type thioredoxin.	Histidine	11-20	thioredoxin	Homo sapiens	94-105
2966489-10	1988	A histidine to tyrosine substitution at the corresponding position of the v-mos protein and the yeast CDC28 gene product causes a similar effect on the kinase activity.	Histidine	2-11	cyclin-dependent serine/threonine-protein kinase CDC28	Saccharomyces cerevisiae S288C	102-107
8617783-6	1996	All of the histidine mutants exhibited decreased thermal stability as compared with wild-type thioredoxin; however, the introduction of an additional mutation, D26A, increased their melting temperatures beyond that of wild-type thioredoxin.	Histidine	11-20	thioredoxin	Homo sapiens	228-239
8617783-7	1996	The metal chelating abilities of these histidine mutants of thioredoxin were successfully utilized for convenient purifications of human interleukin-8 and -11 expressed in E. coli as soluble thioredoxin fusion proteins.	Histidine	39-48	thioredoxin	Homo sapiens	60-71
8617783-7	1996	The metal chelating abilities of these histidine mutants of thioredoxin were successfully utilized for convenient purifications of human interleukin-8 and -11 expressed in E. coli as soluble thioredoxin fusion proteins.	Histidine	39-48	thioredoxin	Homo sapiens	191-202
3162733-1	1988	Congenital substitution of arginine 393 to cysteine in antithrombin Northwick Park and to histidine in antithrombin Glasgow.	Histidine	90-99	serpin family C member 1	Homo sapiens	103-115
9172776-2	1996	A recombinant baculovirus was generated which contains the mouse FAK cDNA cloned into a histidine tag transfer vector.	Histidine	88-97	PTK2 protein tyrosine kinase 2	Mus musculus	65-68
8547275-0	1996	Heme oxygenase (HO-1): His-132 stabilizes a distal water ligand and assists catalysis.	Histidine	23-26	heme oxygenase 1	Homo sapiens	16-20
8547275-1	1996	His-25 and His-132 are the primary candidates for the proximal heme iron ligand in heme oxygenase isozyme-1 (HO-1).	Histidine	0-3	heme oxygenase 1	Homo sapiens	83-107
8547275-1	1996	His-25 and His-132 are the primary candidates for the proximal heme iron ligand in heme oxygenase isozyme-1 (HO-1).	Histidine	0-3	heme oxygenase 1	Homo sapiens	109-113
22103913-8	2011	Histidine (His)-tagged PTEN fusion protein was generated in Sf9 baculovirus expression system.	Histidine	0-9	phosphatase and tensin homolog	Homo sapiens	23-27
22103913-8	2011	Histidine (His)-tagged PTEN fusion protein was generated in Sf9 baculovirus expression system.	Histidine	0-3	phosphatase and tensin homolog	Homo sapiens	23-27
22057958-5	2011	Sequence analysis showed that five binding sites of iron, including  two consensus histidines in the LOX domain, are highly conserved in the  cucumber LOX proteins.	Histidine	83-93	linoleate 9S-lipoxygenase 6-like	Cucumis sativus	101-104
8547275-1	1996	His-25 and His-132 are the primary candidates for the proximal heme iron ligand in heme oxygenase isozyme-1 (HO-1).	Histidine	11-14	heme oxygenase 1	Homo sapiens	83-107
22057958-5	2011	Sequence analysis showed that five binding sites of iron, including  two consensus histidines in the LOX domain, are highly conserved in the  cucumber LOX proteins.	Histidine	83-93	linoleate 9S-lipoxygenase 6-like	Cucumis sativus	151-154
2840927-3	1988	The 15 amino-acid-residue sequence comprising the histidine-715, supposed to be of importance for the biological function of EF-2, is preserved in human EF-2.	Histidine	50-59	eukaryotic translation elongation factor 2	Homo sapiens	125-129
21849510-5	2011	C-terminal topology reporters added to truncated versions of Gup1p yield a topology predicting a lumenal location of its uniquely conserved histidine 447 residue.	Histidine	140-149	O-acyltransferase	Saccharomyces cerevisiae S288C	61-66
21849510-6	2011	The same approach shows that Ale1p and Are2p also have the uniquely conserved histidine residing in the ER lumen.	Histidine	78-87	sterol acyltransferase	Saccharomyces cerevisiae S288C	39-44
8547275-1	1996	His-25 and His-132 are the primary candidates for the proximal heme iron ligand in heme oxygenase isozyme-1 (HO-1).	Histidine	11-14	heme oxygenase 1	Homo sapiens	109-113
8547275-7	1996	These results place His-132 close to the iron on the distal side of the heme pocket and indicate that His-132 facilitates, but is not absolutely required for, the catalytic turnover of HO-1.	Histidine	20-23	heme oxygenase 1	Homo sapiens	185-189
8547275-7	1996	These results place His-132 close to the iron on the distal side of the heme pocket and indicate that His-132 facilitates, but is not absolutely required for, the catalytic turnover of HO-1.	Histidine	102-105	heme oxygenase 1	Homo sapiens	185-189
8547339-15	1996	We propose that mouse CPO is copper-containing enzyme and Cu2+ interacts with a conserved histidine residue.	Histidine	90-99	coproporphyrinogen oxidase	Mus musculus	22-25
2840927-3	1988	The 15 amino-acid-residue sequence comprising the histidine-715, supposed to be of importance for the biological function of EF-2, is preserved in human EF-2.	Histidine	50-59	eukaryotic translation elongation factor 2	Homo sapiens	153-157
8550561-11	1996	PAF transacetylase activity is widely distributed among several tissues and may involve histidine and cysteine for its catalytic activity due to inhibitory effects to the enzyme by diethyl pyrocarbonate and N-ethylmaleimide, respectively.	Histidine	88-97	PCNA clamp associated factor	Homo sapiens	0-3
2900016-4	1988	The amino-acid composition of erythrocyte transglutaminase differed substantially from that of the guinea-pig liver enzyme, notably with respect to the number of histidine, cysteine and acidic amino-acid residues.	Histidine	162-171	protein-glutamine gamma-glutamyltransferase 2	Cavia porcellus	42-58
8881287-4	1996	Use of deletion mutants showed that both activation functions (AF1 and AF2) of PR as well as the coiled coil and His-Cys rich domains of PML were required for transcriptional enhancement.	Histidine	113-116	PML nuclear body scaffold	Homo sapiens	137-140
8907170-8	1996	103, 4912-4921], the anti-Curie behavior observed for the heme methyl proton resonance in met-cyano cytochrome c is attributed to a rotational displacement of the heme about the iron-His bond relative to the protein moiety due to a temperature-dependent conformational alteration of the heme-protein linkage.	Histidine	183-186	cytochrome c, somatic	Equus caballus	100-112
21647154-3	2011	The identified IDH1 mutations occurred in codon 132 resulting in replacement of arginine with either cysteine (N=3) or histidine (N=1).	Histidine	119-128	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	15-19
21730068-4	2011	Detailed analysis, including a comparison of the tertiary structure of Pos5 with the structures of human and bacterial NAD kinases, revealed that Arg-293 of Pos5, corresponding to His-351 of human NAD kinase, confers a positive charge on the surface of NADH-binding site, whereas the corresponding His residue does not.	Histidine	180-183	NAD kinase	Homo sapiens	119-129
21730068-4	2011	Detailed analysis, including a comparison of the tertiary structure of Pos5 with the structures of human and bacterial NAD kinases, revealed that Arg-293 of Pos5, corresponding to His-351 of human NAD kinase, confers a positive charge on the surface of NADH-binding site, whereas the corresponding His residue does not.	Histidine	298-301	NAD kinase	Homo sapiens	119-129
21730068-6	2011	Conversely, simultaneous changes of Ala-330 and His-351 of human NAD kinase into Ser and Arg residues significantly increased the ratio of NADH kinase activity to NAD kinase activity from 0.043 to 1.39; human Ala-330 corresponds to Pos5 Ser-272, which interacts with the side chain of Arg-293.	Histidine	48-51	NAD kinase	Homo sapiens	65-75
21730068-6	2011	Conversely, simultaneous changes of Ala-330 and His-351 of human NAD kinase into Ser and Arg residues significantly increased the ratio of NADH kinase activity to NAD kinase activity from 0.043 to 1.39; human Ala-330 corresponds to Pos5 Ser-272, which interacts with the side chain of Arg-293.	Histidine	48-51	NAD kinase	Homo sapiens	163-173
21680741-2	2011	Based on the crystal structure of the oxygenase component (C(2)), His-396 is 4.5 A from the flavin C4a locus, whereas Ser-171 is 2.9 A from the flavin N5 locus.	Histidine	66-69	complement C4A (Rodgers blood group)	Homo sapiens	99-102
3275777-7	1988	10-fold) in renin inhibitory activity as exemplified by the pentapeptide Ac-Ftr-Pro-Phe-His-Sta-NH2 (12; IC50 = 3.8 X 10(-9) M).	Histidine	88-91	GCY	Homo sapiens	92-95
3238351-5	1988	Furthermore, it was found that the interaction between the streptococcal IgG Fc receptor and IgG--like the RF/IgG interaction--took place in the interface between C gamma 2 and C gamma 3 and that histidine 435, tyrosine 436 and/or one both of histidine 433 and 310 were involved.	Histidine	243-252	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	163-186
21787747-2	2011	In this study we identified the catalytic triad of diacylglycerol lipase alpha, consisting of serine 472, aspartate 524 and histidine 650.	Histidine	124-133	diacylglycerol lipase alpha	Homo sapiens	51-78
8553584-7	1996	Purified recombinant histidine-tagged PKR(1-551)K296R mutant protein was phosphorylated by purified wild-type PKR; this intermolecular phosphorylation of PKR was dependent on double-stranded RNA.	Histidine	21-30	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	38-41
8553584-7	1996	Purified recombinant histidine-tagged PKR(1-551)K296R mutant protein was phosphorylated by purified wild-type PKR; this intermolecular phosphorylation of PKR was dependent on double-stranded RNA.	Histidine	21-30	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	110-113
8553584-7	1996	Purified recombinant histidine-tagged PKR(1-551)K296R mutant protein was phosphorylated by purified wild-type PKR; this intermolecular phosphorylation of PKR was dependent on double-stranded RNA.	Histidine	21-30	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	110-113
8553584-8	1996	At a fixed RNA concentration, high concentrations of the HIS-PKR(1-551)K296R mutant both impaired the autophosphorylation of wild-type PKR and blocked the trans-phosphorylation of itself.	Histidine	57-60	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	61-64
8553584-8	1996	At a fixed RNA concentration, high concentrations of the HIS-PKR(1-551)K296R mutant both impaired the autophosphorylation of wild-type PKR and blocked the trans-phosphorylation of itself.	Histidine	57-60	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	135-138
3566767-0	1987	Evidence for the involvement of histidine at the active site of glutathione S-transferase psi from human liver.	Histidine	32-41	glutathione S-transferase kappa 1	Homo sapiens	64-89
8618839-5	1995	AAT1-mediated histidine transport is sensitive to protonophores and occurs against a concentration gradient, indicating that AAT1 may function as a proton symporter.	Histidine	14-23	amino acid transporter 1	Arabidopsis thaliana	125-129
20652826-7	2011	LPS treatment of HepG2 cells transiently expressing a histidine-tagged human cardiolipin synthase-1 (hCLS1) reduced hCLS1 mRNA and newly synthesized CLS activity indicating that LPS inhibits production of newly synthesized hCLS1 via reduction in hCLS1 mRNA.	Histidine	54-63	cardiolipin synthase 1	Homo sapiens	77-99
20652826-7	2011	LPS treatment of HepG2 cells transiently expressing a histidine-tagged human cardiolipin synthase-1 (hCLS1) reduced hCLS1 mRNA and newly synthesized CLS activity indicating that LPS inhibits production of newly synthesized hCLS1 via reduction in hCLS1 mRNA.	Histidine	54-63	cardiolipin synthase 1	Homo sapiens	101-106
20652826-7	2011	LPS treatment of HepG2 cells transiently expressing a histidine-tagged human cardiolipin synthase-1 (hCLS1) reduced hCLS1 mRNA and newly synthesized CLS activity indicating that LPS inhibits production of newly synthesized hCLS1 via reduction in hCLS1 mRNA.	Histidine	54-63	cardiolipin synthase 1	Homo sapiens	116-121
20652826-7	2011	LPS treatment of HepG2 cells transiently expressing a histidine-tagged human cardiolipin synthase-1 (hCLS1) reduced hCLS1 mRNA and newly synthesized CLS activity indicating that LPS inhibits production of newly synthesized hCLS1 via reduction in hCLS1 mRNA.	Histidine	54-63	cardiolipin synthase 1	Homo sapiens	102-105
20652826-7	2011	LPS treatment of HepG2 cells transiently expressing a histidine-tagged human cardiolipin synthase-1 (hCLS1) reduced hCLS1 mRNA and newly synthesized CLS activity indicating that LPS inhibits production of newly synthesized hCLS1 via reduction in hCLS1 mRNA.	Histidine	54-63	cardiolipin synthase 1	Homo sapiens	116-121
20652826-7	2011	LPS treatment of HepG2 cells transiently expressing a histidine-tagged human cardiolipin synthase-1 (hCLS1) reduced hCLS1 mRNA and newly synthesized CLS activity indicating that LPS inhibits production of newly synthesized hCLS1 via reduction in hCLS1 mRNA.	Histidine	54-63	cardiolipin synthase 1	Homo sapiens	116-121
7498539-1	1995	When monitored by 1H NMR at various pH values, most of the C-2 proton signals from 12 His residues of the isolated beta subunit of thermophilic F1-ATPase (TF1) could be separately observed.	Histidine	86-89	complement C2	Homo sapiens	59-62
3492201-4	1986	Rat EGF contains six aromatic residues, i.e. one histidine and five tyrosine residues.	Histidine	49-58	epidermal growth factor	Rattus norvegicus	4-7
8720075-8	1995	alpha1,3GT linked to six histidines (His)6 at the N-terminus.	Histidine	25-35	adrenoceptor alpha 1D	Homo sapiens	0-10
8720075-8	1995	alpha1,3GT linked to six histidines (His)6 at the N-terminus.	Histidine	37-40	adrenoceptor alpha 1D	Homo sapiens	0-10
8522591-3	1995	Expression of K18 arg89--&gt;his/cys and its normal K8 partner in cultured cells resulted in punctate staining as compared with the typical filaments obtained after expression of wild-type K8/18.	Histidine	29-32	keratin 8	Mus musculus	189-194
21811984-5	2011	RESULTS: A heterozygous 467G&gt;A mutation was found in the patient, resulting in the substitution of arginine (R) by histidine (H) in codon 156 (R156H) in the 1A domain of the KRT10 protein but not in the healthy individuals from the family and the 50 unrelated individuals.	Histidine	118-127	keratin 10	Homo sapiens	177-182
21402045-5	2011	The presence of these vesicles in the reaction buffer enhanced the specific activity of the His-tagged PDK1 (full-length, and the truncated kinase domain) and the activity of the full-length His-tagged AKT1 and AKT2 when assayed in a cascade-type reaction.	Histidine	92-95	pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial	Cricetulus griseus	103-107
3492201-8	1986	data give evidence for solvent exposure of the one histidine and the five tyrosine residues in rat EGF.	Histidine	51-60	epidermal growth factor	Rattus norvegicus	99-102
8614401-2	1995	The Mus musculus molossinus Sry open reading frame (ORF) encodes a 395-amino acid transcription factor (mSry) that specifically binds and bends DNA through its N-terminal HMG domain and activates transcription through its long C-terminal (residues 144-366) glutamine/histidine-rich activation domain.	Histidine	267-276	sex determining region Y	Homo sapiens	28-31
3026342-9	1986	The only other residue altered by H2O2 treatment of alpha 2M was histidine.	Histidine	65-74	alpha-2-macroglobulin	Homo sapiens	52-60
8614415-4	1995	The use of deletion mutants showed that both activation functions (AF1 and AF2) of PR as well as the coiled coil and His-Cys-rich domains of PML were required for transcriptional enhancement.	Histidine	117-120	PML nuclear body scaffold	Homo sapiens	141-144
8825099-2	1995	This class of bacterial sensory kinases, typified by ArcB and BarA, possesses two phospho-donor (His) sites, together with a phospho-accepting (Asp) site.	Histidine	97-100	hypothetical protein	Escherichia coli	53-57
21324097-2	2011	The substitution of arginine (R) for histidine (H) in the 131 position defines three allelic patterns, H/H, R/R, and H/R, resulting in FcgammaRIIA-H/H131 affinity for IgG2 and higher affinity for IgG3 subclasses.	Histidine	37-46	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	196-200
3026342-12	1986	This treatment modified 53 histidine residues in both native and fast-form alpha 2M.	Histidine	27-36	alpha-2-macroglobulin	Homo sapiens	75-83
8847995-2	1995	This mutation results in substitution of histidine by glutamine in the PLP molecule and produces severe hypomyelination.	Histidine	41-50	myelin proteolipid protein	Oryctolagus cuniculus	71-74
21449573-3	2011	It has been confirmed that FXYD1 spontaneously associates in vitro with the alpha(1)/His(10)-beta(1) complex and stabilizes it in an active mode.	Histidine	85-88	adrenoceptor alpha 1D	Homo sapiens	76-84
3016549-1	1986	Cytochrome c can be modified by [(NH3)5RuII/III-] specifically at the imidazole moiety of histidine 33, and we have recently discussed the thermodynamics and kinetics of electron transfer within this modified protein.	Histidine	90-99	cytochrome c, somatic	Equus caballus	0-12
21449573-4	2011	The functional properties of the alpha(1)/His(10)-beta(1) and alpha(1)/His(10)-beta(1)/FXYD1 complexes have been investigated by fluorescence methods.	Histidine	42-45	adrenoceptor alpha 1D	Homo sapiens	33-41
21449573-4	2011	The functional properties of the alpha(1)/His(10)-beta(1) and alpha(1)/His(10)-beta(1)/FXYD1 complexes have been investigated by fluorescence methods.	Histidine	71-74	adrenoceptor alpha 1D	Homo sapiens	62-70
21563332-0	2004	(111)In-DOTA-4-amino-1-carboxymethyl-piperidine-D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2 The amphibian bombesin (BBN or BN, a peptide of 14 amino acids) is an analog of human gastrin-releasing peptide (GRP, a peptide of 27 amino acids) that binds to GRP receptor (GRPR) with high affinity and specificity (1).	Histidine	74-77	GCY	Homo sapiens	78-81
21563332-12	2004	A DOTA-Gly-benzoyl group was added to the C-terminus to form DOTA-Gly-benzoyl-d-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2 (RM1).	Histidine	104-107	GCY	Homo sapiens	108-111
7489765-6	1995	HLA-B*2709 differs from the most frequent and disease-associated HLA-B*2705 allele for a single substitution (His vs. Asp) at position 116.	Histidine	110-113	major histocompatibility complex, class I, B	Homo sapiens	0-5
7489765-6	1995	HLA-B*2709 differs from the most frequent and disease-associated HLA-B*2705 allele for a single substitution (His vs. Asp) at position 116.	Histidine	110-113	major histocompatibility complex, class I, B	Homo sapiens	65-70
3729426-1	1986	1H-NMR spectra for the angiotensin agonist sarcosine-(Sar)Arg-Val-Tyr-Ile-His-Sar-Phe [( Sar1,Sar7]Ang II) and the antagonist Sar-Arg-Val-Tyr-Ile-His-Sar-Ile in dimethylsulfoxide-d6 were examined at 400 MHz.	Histidine	74-77	secretion associated Ras related GTPase 1A	Homo sapiens	89-105
8561849-11	1995	His-400 may act as a zinc-binding ligand similar to the His-197 in interstitial collagenase (MMP-7) and Asp-432 and Asp-433 residues are probably involved in stabilization of the active site of the enzyme.	Histidine	0-3	matrix metallopeptidase 1	Homo sapiens	67-91
8561849-11	1995	His-400 may act as a zinc-binding ligand similar to the His-197 in interstitial collagenase (MMP-7) and Asp-432 and Asp-433 residues are probably involved in stabilization of the active site of the enzyme.	Histidine	0-3	matrix metallopeptidase 7	Homo sapiens	93-98
8561849-11	1995	His-400 may act as a zinc-binding ligand similar to the His-197 in interstitial collagenase (MMP-7) and Asp-432 and Asp-433 residues are probably involved in stabilization of the active site of the enzyme.	Histidine	56-59	matrix metallopeptidase 1	Homo sapiens	67-91
8561849-11	1995	His-400 may act as a zinc-binding ligand similar to the His-197 in interstitial collagenase (MMP-7) and Asp-432 and Asp-433 residues are probably involved in stabilization of the active site of the enzyme.	Histidine	56-59	matrix metallopeptidase 7	Homo sapiens	93-98
8561849-12	1995	The His-400 and Asp-433 residues are conserved in all members of the MMP family.	Histidine	4-7	matrix metallopeptidase 1	Homo sapiens	69-72
21183608-6	2011	RESULTS: Children with the EPHX1 Arg/His or Arg/Arg genotypes at codon 139 were significantly associated with increased risks of lifetime asthma (adjusted OR [aOR] = 1.3; 95% CI, 1.1-1.7; and aOR = 1.5; 95% CI, 1.1-2.1, respectively).	Histidine	37-40	epoxide hydrolase 1	Homo sapiens	27-32
3729426-3	1986	Comparison of the chemical shifts for the His6 and Phe8 ring protons in these peptides suggested a His/Phe stacking interaction in [Sar1,Sar7]Ang II which is important for agonist activity.	Histidine	42-45	secretion associated Ras related GTPase 1A	Homo sapiens	132-148
3736769-5	1986	His was reduced by about 90% in the CSF, in the plasma and in the urine.	Histidine	0-3	colony stimulating factor 2	Homo sapiens	36-39
21212878-0	2011	The role of His-50 of alpha-synuclein in binding Cu(II): pH dependence, speciation, thermodynamics and structure.	Histidine	12-15	synuclein alpha	Homo sapiens	22-37
7480319-1	1995	Imidazoleglycerolphosphate dehydratase (IGPD; EC 4.2.1.19), which is involved in the histidine biosynthetic pathway of Arabidopsis thaliana and wheat (Triticum aestivum), has been expressed in insect cells using the baculovirus expression vector system.	Histidine	85-94	imidazoleglycerol-phosphate dehydratase	Arabidopsis thaliana	0-38
7480319-1	1995	Imidazoleglycerolphosphate dehydratase (IGPD; EC 4.2.1.19), which is involved in the histidine biosynthetic pathway of Arabidopsis thaliana and wheat (Triticum aestivum), has been expressed in insect cells using the baculovirus expression vector system.	Histidine	85-94	imidazoleglycerol-phosphate dehydratase	Arabidopsis thaliana	40-44
21359214-0	2011	Histidine hydrogen-deuterium exchange mass spectrometry for probing the microenvironment of histidine residues in dihydrofolate reductase.	Histidine	0-9	Dihydrofolate reductase	Escherichia coli	114-137
21359214-0	2011	Histidine hydrogen-deuterium exchange mass spectrometry for probing the microenvironment of histidine residues in dihydrofolate reductase.	Histidine	92-101	Dihydrofolate reductase	Escherichia coli	114-137
21359214-3	2011	His-HDX-MS was used to probe the microenvironment of histidine residues of E. coli dihydrofolate reductase (DHFR), an enzyme proposed to undergo multiple conformational changes during catalysis.	Histidine	53-62	Dihydrofolate reductase	Escherichia coli	83-106
7642636-8	1995	Site-directed mutagenesis confirmed the prediction that the conversion of His residues 8,68, and 70 in the positively charged region into Glu prevents the binding of pro-mMCP-7 to heparin.	Histidine	74-77	tryptase alpha/beta 1	Mus musculus	170-176
7642636-9	1995	Because the binding requires positively charged His residues, native mMCP-7 is able to dissociate from the protease/proteoglycan macromolecular complex when the complex is exocytosed from bone marrow-derived mast cells into a neutral pH environment.	Histidine	48-51	tryptase alpha/beta 1	Mus musculus	69-75
2422647-5	1986	The active site residues of histidine, aspartic acid, and serine comprising the charge-relay system of typical serine proteases were found in similar positions in PA (histidine-41, aspartic acid-96, and serine-192).	Histidine	28-37	kallikrein related peptidase 3	Homo sapiens	163-165
7642551-6	1995	Mutations at FKBP12 residues Asp-37, Arg-42, His-87, and Ile-90 decrease calcineurin affinity of the mutant FKBP12.FK506 complex by as much as 2600-fold in the case of I90K.	Histidine	45-48	FKBP prolyl isomerase 1A pseudogene 4	Homo sapiens	13-19
7642551-6	1995	Mutations at FKBP12 residues Asp-37, Arg-42, His-87, and Ile-90 decrease calcineurin affinity of the mutant FKBP12.FK506 complex by as much as 2600-fold in the case of I90K.	Histidine	45-48	FKBP prolyl isomerase 1A pseudogene 4	Homo sapiens	108-114
21359214-3	2011	His-HDX-MS was used to probe the microenvironment of histidine residues of E. coli dihydrofolate reductase (DHFR), an enzyme proposed to undergo multiple conformational changes during catalysis.	Histidine	53-62	Dihydrofolate reductase	Escherichia coli	108-112
21359214-4	2011	METHODOLOGY/PRINCIPAL FINDINGS: Using His-HDX-MS, the pK(a) values and the half-lives (t(1/2)) of HDX reactions of five histidine residues of apo-DHFR, DHFR in complex with methotrexate (DHFR-MTX), DHFR in complex with MTX and NADPH (DHFR-MTX-NADPH), and DHFR in complex with folate and NADP+ (DHFR-folate-NADP+) were determined.	Histidine	120-129	Dihydrofolate reductase	Escherichia coli	146-150
21359214-4	2011	METHODOLOGY/PRINCIPAL FINDINGS: Using His-HDX-MS, the pK(a) values and the half-lives (t(1/2)) of HDX reactions of five histidine residues of apo-DHFR, DHFR in complex with methotrexate (DHFR-MTX), DHFR in complex with MTX and NADPH (DHFR-MTX-NADPH), and DHFR in complex with folate and NADP+ (DHFR-folate-NADP+) were determined.	Histidine	120-129	Dihydrofolate reductase	Escherichia coli	152-156
21359214-4	2011	METHODOLOGY/PRINCIPAL FINDINGS: Using His-HDX-MS, the pK(a) values and the half-lives (t(1/2)) of HDX reactions of five histidine residues of apo-DHFR, DHFR in complex with methotrexate (DHFR-MTX), DHFR in complex with MTX and NADPH (DHFR-MTX-NADPH), and DHFR in complex with folate and NADP+ (DHFR-folate-NADP+) were determined.	Histidine	120-129	Dihydrofolate reductase	Escherichia coli	152-156
21359214-4	2011	METHODOLOGY/PRINCIPAL FINDINGS: Using His-HDX-MS, the pK(a) values and the half-lives (t(1/2)) of HDX reactions of five histidine residues of apo-DHFR, DHFR in complex with methotrexate (DHFR-MTX), DHFR in complex with MTX and NADPH (DHFR-MTX-NADPH), and DHFR in complex with folate and NADP+ (DHFR-folate-NADP+) were determined.	Histidine	120-129	Dihydrofolate reductase	Escherichia coli	152-156
7556478-8	1995	These data confirm the roles of histidine in the catalytic process of this enzyme-crystallin and suggest that the change of His91 to Gln91 observed in the duck and chicken delta 1-crystallin molecules may be sufficient to account for the lack of enzymatic activity of those proteins.	Histidine	32-41	delta-1 crystallin	Gallus gallus	172-190
2422647-5	1986	The active site residues of histidine, aspartic acid, and serine comprising the charge-relay system of typical serine proteases were found in similar positions in PA (histidine-41, aspartic acid-96, and serine-192).	Histidine	167-176	kallikrein related peptidase 3	Homo sapiens	163-165
21359214-4	2011	METHODOLOGY/PRINCIPAL FINDINGS: Using His-HDX-MS, the pK(a) values and the half-lives (t(1/2)) of HDX reactions of five histidine residues of apo-DHFR, DHFR in complex with methotrexate (DHFR-MTX), DHFR in complex with MTX and NADPH (DHFR-MTX-NADPH), and DHFR in complex with folate and NADP+ (DHFR-folate-NADP+) were determined.	Histidine	120-129	Dihydrofolate reductase	Escherichia coli	152-156
21359214-4	2011	METHODOLOGY/PRINCIPAL FINDINGS: Using His-HDX-MS, the pK(a) values and the half-lives (t(1/2)) of HDX reactions of five histidine residues of apo-DHFR, DHFR in complex with methotrexate (DHFR-MTX), DHFR in complex with MTX and NADPH (DHFR-MTX-NADPH), and DHFR in complex with folate and NADP+ (DHFR-folate-NADP+) were determined.	Histidine	120-129	Dihydrofolate reductase	Escherichia coli	152-156
21359214-4	2011	METHODOLOGY/PRINCIPAL FINDINGS: Using His-HDX-MS, the pK(a) values and the half-lives (t(1/2)) of HDX reactions of five histidine residues of apo-DHFR, DHFR in complex with methotrexate (DHFR-MTX), DHFR in complex with MTX and NADPH (DHFR-MTX-NADPH), and DHFR in complex with folate and NADP+ (DHFR-folate-NADP+) were determined.	Histidine	120-129	Dihydrofolate reductase	Escherichia coli	152-156
7541849-2	1995	A catalytically deficient, histidine-tagged mutant PKR protein [His-PKR(K296R)] was used as the substrate for characterization of the intermolecular phosphorylation catalyzed by purified wild-type PKR [PKR(Wt)].	Histidine	27-36	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	51-54
2422647-7	1986	The cleavage sites of these proteins by PA were chemically analyzed as the alpha-carboxyl side of some hydrophobic residues, tyrosine, leucine, valine, and phenylalanine, and of basic residues histidine, lysine, and arginine.	Histidine	193-202	kallikrein related peptidase 3	Homo sapiens	40-42
7541849-2	1995	A catalytically deficient, histidine-tagged mutant PKR protein [His-PKR(K296R)] was used as the substrate for characterization of the intermolecular phosphorylation catalyzed by purified wild-type PKR [PKR(Wt)].	Histidine	27-36	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	68-71
7541849-2	1995	A catalytically deficient, histidine-tagged mutant PKR protein [His-PKR(K296R)] was used as the substrate for characterization of the intermolecular phosphorylation catalyzed by purified wild-type PKR [PKR(Wt)].	Histidine	27-36	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	68-71
3088682-2	1986	Peptides related to thyrotropin releasing hormone (TRH) were identified in the eluted fractions by trypsin digestion and radioimmunoassay (RIA) using antibodies to the TRH tripeptide pGlu-His-Pro amide or to a TRH-related pentapeptide pGlu-His-Pro-Gly-Lys.	Histidine	188-191	thyrotropin-releasing hormone L homeolog	Xenopus laevis	20-49
7541849-2	1995	A catalytically deficient, histidine-tagged mutant PKR protein [His-PKR(K296R)] was used as the substrate for characterization of the intermolecular phosphorylation catalyzed by purified wild-type PKR [PKR(Wt)].	Histidine	27-36	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	68-71
7541849-2	1995	A catalytically deficient, histidine-tagged mutant PKR protein [His-PKR(K296R)] was used as the substrate for characterization of the intermolecular phosphorylation catalyzed by purified wild-type PKR [PKR(Wt)].	Histidine	64-67	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	51-54
7541849-2	1995	A catalytically deficient, histidine-tagged mutant PKR protein [His-PKR(K296R)] was used as the substrate for characterization of the intermolecular phosphorylation catalyzed by purified wild-type PKR [PKR(Wt)].	Histidine	64-67	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	68-71
7541849-2	1995	A catalytically deficient, histidine-tagged mutant PKR protein [His-PKR(K296R)] was used as the substrate for characterization of the intermolecular phosphorylation catalyzed by purified wild-type PKR [PKR(Wt)].	Histidine	64-67	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	68-71
7541849-2	1995	A catalytically deficient, histidine-tagged mutant PKR protein [His-PKR(K296R)] was used as the substrate for characterization of the intermolecular phosphorylation catalyzed by purified wild-type PKR [PKR(Wt)].	Histidine	64-67	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	68-71
7541849-3	1995	The intermolecular autophosphorylation of His-PKR(K296R) by PKR(Wt) was RNA dependent.	Histidine	42-45	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	46-49
7541849-3	1995	The intermolecular autophosphorylation of His-PKR(K296R) by PKR(Wt) was RNA dependent.	Histidine	42-45	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	60-67
7541849-4	1995	Excess His-PKR(K296R) substrate inhibited both the auto- and the trans-phosphorylation activities of PKR(Wt).	Histidine	7-10	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	11-14
21290626-0	2004	3-Cyano-4-[(18)F]fluoro-benzoyl-Arg-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2 3-Cyano-4-[(18)F]fluoro-benzoyl-Arg-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2, abbreviated as [(18)F]6b, is a bombesin (BN)-based (18)F-labeled peptide synthesized by Mu et al.	Histidine	63-66	GCY	Homo sapiens	67-70
21290626-0	2004	3-Cyano-4-[(18)F]fluoro-benzoyl-Arg-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2 3-Cyano-4-[(18)F]fluoro-benzoyl-Arg-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2, abbreviated as [(18)F]6b, is a bombesin (BN)-based (18)F-labeled peptide synthesized by Mu et al.	Histidine	63-66	GCY	Homo sapiens	146-149
21290626-0	2004	3-Cyano-4-[(18)F]fluoro-benzoyl-Arg-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2 3-Cyano-4-[(18)F]fluoro-benzoyl-Arg-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2, abbreviated as [(18)F]6b, is a bombesin (BN)-based (18)F-labeled peptide synthesized by Mu et al.	Histidine	142-145	GCY	Homo sapiens	67-70
21290626-0	2004	3-Cyano-4-[(18)F]fluoro-benzoyl-Arg-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2 3-Cyano-4-[(18)F]fluoro-benzoyl-Arg-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2, abbreviated as [(18)F]6b, is a bombesin (BN)-based (18)F-labeled peptide synthesized by Mu et al.	Histidine	142-145	GCY	Homo sapiens	146-149
21290627-0	2004	3-Cyano-4-[(18)F]fluoro-benzoyl-Ala(SO3H)-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2 3-Cyano-4-[(18)F]fluoro-benzoyl-Ala(SO3H)-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2, abbreviated as [(18)F]7b, is a bombesin (BN)-based (18)F-labeled peptide synthesized by Mu et al.	Histidine	69-72	GCY	Homo sapiens	73-76
21290627-0	2004	3-Cyano-4-[(18)F]fluoro-benzoyl-Ala(SO3H)-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2 3-Cyano-4-[(18)F]fluoro-benzoyl-Ala(SO3H)-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2, abbreviated as [(18)F]7b, is a bombesin (BN)-based (18)F-labeled peptide synthesized by Mu et al.	Histidine	69-72	GCY	Homo sapiens	158-161
7608158-2	1995	Pig and human myoglobin have been engineered to reverse the positions of the distal histidine and valine (i.e. His64(E7)--&gt;Val and Val68(E11)--&gt;His).	Histidine	84-93	myoglobin	Homo sapiens	14-23
7608158-2	1995	Pig and human myoglobin have been engineered to reverse the positions of the distal histidine and valine (i.e. His64(E7)--&gt;Val and Val68(E11)--&gt;His).	Histidine	111-114	myoglobin	Homo sapiens	14-23
3088682-2	1986	Peptides related to thyrotropin releasing hormone (TRH) were identified in the eluted fractions by trypsin digestion and radioimmunoassay (RIA) using antibodies to the TRH tripeptide pGlu-His-Pro amide or to a TRH-related pentapeptide pGlu-His-Pro-Gly-Lys.	Histidine	188-191	thyrotropin-releasing hormone L homeolog	Xenopus laevis	51-54
3088682-5	1986	Evidence was also obtained for the presence of small amounts of the TRH-related pentapeptide pGlu-His-Pro-Gly-Lys.	Histidine	98-101	thyrotropin-releasing hormone L homeolog	Xenopus laevis	68-71
7790073-12	1995	Thus, HIS-62 is a member of the hsp 60 family, and the recombinant hsp 60 is protective against pulmonary histoplasmosis in mice.	Histidine	6-9	heat shock protein 1 (chaperonin)	Mus musculus	32-38
3486005-4	1986	Chemical modification of arginine and histidine residues on C1q as well as pretreatment of C1q at pH 4.45 or at 56 degrees C reduced its spectrin binding activity.	Histidine	38-47	complement C1q A chain	Homo sapiens	60-63
7790073-12	1995	Thus, HIS-62 is a member of the hsp 60 family, and the recombinant hsp 60 is protective against pulmonary histoplasmosis in mice.	Histidine	6-9	heat shock protein 1 (chaperonin)	Mus musculus	67-73
7608102-3	1995	We used Gln3p tagged with six histidine codons at the 5" terminus and equipped with a galactose-inducible promoter to overproduce histidine-tagged Gln3p.	Histidine	30-39	nitrogen-responsive transcriptional regulator GLN3	Saccharomyces cerevisiae S288C	8-13
7608102-3	1995	We used Gln3p tagged with six histidine codons at the 5" terminus and equipped with a galactose-inducible promoter to overproduce histidine-tagged Gln3p.	Histidine	130-139	nitrogen-responsive transcriptional regulator GLN3	Saccharomyces cerevisiae S288C	8-13
7608102-3	1995	We used Gln3p tagged with six histidine codons at the 5" terminus and equipped with a galactose-inducible promoter to overproduce histidine-tagged Gln3p.	Histidine	130-139	nitrogen-responsive transcriptional regulator GLN3	Saccharomyces cerevisiae S288C	147-152
21734345-7	2011	Analysis of combinations showed a significant association of 113His/His EPHX1/null-GSTM1 (OR=4.07) and null-GSTM1/105Val/Val GSTP1 (OR =3.56) genotypes with increased risk of COPD (respectively P=0.0094 and P=0.0153).	Histidine	64-67	epoxide hydrolase 1	Homo sapiens	72-77
21966400-0	2011	Fibrillization of human tau is accelerated by exposure to lead via interaction with His-330 and His-362.	Histidine	84-87	microtubule associated protein tau	Homo sapiens	24-27
21085684-2	2010	Two classical PLDs, PLD1 and PLD2, contain phosphatidylinositide-binding PX and PH domains and two conserved His-x-Lys-(x)(4)-Asp (HKD) motifs, which are critical for PLD activity.	Histidine	109-112	phospholipase D2	Mus musculus	29-33
20828147-8	2010	For this purpose, we produced and purified His-WT alpha-syn, a recombinant alpha-syn with a polyhistidine tag (six His residues) and a linker, and a number of Pro-to-Ala mutants.	Histidine	43-46	synuclein alpha	Homo sapiens	50-59
2864083-6	1985	In contrast, the observed inactivation of the enzyme by p-hydroxymercuribenzoate or p-hydroxymercuriphenylsulfonate is probably due to a modification of a histidine residue, consistent with previous reports that histidine is near the active site of arylsulfatase A.	Histidine	155-164	arylsulfatase A	Oryctolagus cuniculus	249-264
20682345-5	2010	The addition of GST, Trx or GB1 to the N-terminal His(6) tag significantly improved both the expression and solubility of target proteins as compared to His(6) tag alone.	Histidine	50-53	thioredoxin	Homo sapiens	21-24
20682345-5	2010	The addition of GST, Trx or GB1 to the N-terminal His(6) tag significantly improved both the expression and solubility of target proteins as compared to His(6) tag alone.	Histidine	153-156	thioredoxin	Homo sapiens	21-24
7607235-4	1995	The first is defined by a tryptic cleavage at Lys429 and lies within the alpha/beta-hydrolase fold in bile-salt-activated lipase between a central beta-sheet and an active-site histidine residue, as deduced from sequence similarity across the cholinesterases and known structural properties.	Histidine	177-186	carboxyl ester lipase	Homo sapiens	102-128
7721851-7	1995	This set of tPA-specific PAI-1 mutants contained a wide range of amino acid substitutions at P1 including Asn, Gln, His, Ser, Thr, Leu, Met, and all the aromatic amino acids.	Histidine	116-119	serpin family E member 1	Homo sapiens	25-30
7696259-9	1995	Finally, a mutant cholesterol esterase lacking a histidine (435) residue essential for esterasic catalysis was found to be equally capable of increasing sterol transfer and binding to charged monolayers.	Histidine	49-58	carboxyl ester lipase	Homo sapiens	18-38
2864083-6	1985	In contrast, the observed inactivation of the enzyme by p-hydroxymercuribenzoate or p-hydroxymercuriphenylsulfonate is probably due to a modification of a histidine residue, consistent with previous reports that histidine is near the active site of arylsulfatase A.	Histidine	212-221	arylsulfatase A	Oryctolagus cuniculus	249-264
4037808-4	1985	These observations, combined with the result of the deuterium exchange rates of the histidine C-2 protons, led us to conclude that His-25 and His-62, which are buried in the globular domain, play an important role in the conformational stability of histone H5.	Histidine	131-134	complement C2	Homo sapiens	94-97
7988710-5	1994	We have identified one His residue in VMAT1 from rat which is conserved in other vesicular neurotransmitter transporters.	Histidine	23-26	solute carrier family 18 member A1	Rattus norvegicus	38-43
7988710-8	1994	It is concluded that His-419 plays a role in energy coupling in r-VMAT1.	Histidine	21-24	solute carrier family 18 member A1	Rattus norvegicus	66-71
20718505-1	2010	Zif268 is a zinc-finger protein containing three Cys(2)-His(2)-type zinc-finger domains that bind the target DNA sequence GCGTGGGCG in a cooperative manner.	Histidine	56-59	early growth response 1	Homo sapiens	0-6
4037808-4	1985	These observations, combined with the result of the deuterium exchange rates of the histidine C-2 protons, led us to conclude that His-25 and His-62, which are buried in the globular domain, play an important role in the conformational stability of histone H5.	Histidine	142-145	complement C2	Homo sapiens	94-97
7947682-10	1994	A similar experiment using the His-specific reagent diethyl pyrocarbonate indicates that one of the six Fbp-encoded His residues is protected by iron.	Histidine	31-34	folate receptor beta	Homo sapiens	104-107
7947682-10	1994	A similar experiment using the His-specific reagent diethyl pyrocarbonate indicates that one of the six Fbp-encoded His residues is protected by iron.	Histidine	116-119	folate receptor beta	Homo sapiens	104-107
2897250-6	1985	Six of these locations encode the genes for tRNA(phe), tRNA(his), tRNA(trp), and tRNA(glu), and the duplicate tRNA(tyr) genes which are located at the inverted terminal repeat segments.	Histidine	60-63	trnW(uca)	Tetrahymena pyriformis	110-119
7703854-1	1994	To probe the role of the Asp-99 ... His-48 pair in phospholipase A2 (PLA2) catalysis, the X-ray structure and kinetic characterization of the mutant Asp-99--&gt;Asn-99 (D99N) of bovine pancreatic PLA2 was undertaken.	Histidine	36-39	LOC104974671	Bos taurus	69-73
20567816-4	2010	Immunoblotting using anti-6x His and anti-FLAG antibodies revealed that, in addition to full-length protein, Dga1p lacking the N-terminus was produced only in the Deltasnf2 disruptant.	Histidine	29-32	diacylglycerol O-acyltransferase	Saccharomyces cerevisiae S288C	109-114
6096143-2	1984	The results show that the replacement of the distal histidine of the hemoglobin beta chains by an arginine greatly enhances the susceptibility of the heme-iron to oxidative challenge.	Histidine	52-61	hemoglobin subunit beta	Homo sapiens	69-84
20711192-5	2010	Studies with mutant TLR4 proteins revealed that the non-conserved histidines 456 and 458 of human TLR4 are required for activation by Ni(2+) but not by the natural ligand lipopolysaccharide.	Histidine	66-76	toll like receptor 4	Homo sapiens	20-24
20711192-5	2010	Studies with mutant TLR4 proteins revealed that the non-conserved histidines 456 and 458 of human TLR4 are required for activation by Ni(2+) but not by the natural ligand lipopolysaccharide.	Histidine	66-76	toll like receptor 4	Homo sapiens	98-102
7957907-0	1994	Antithrombin histidine variants 1H NMR resonance assignments and functional properties.	Histidine	13-22	serpin family C member 1	Homo sapiens	0-12
7918443-9	1994	Computer graphics of the three-dimensional structure of beta 2M suggested that the high specificity for the glycated site at Ile-1 may be explained by its high solvent accessibility and the nearby imidazole group of His-31 as an acid-base catalyst of the Amadori rearrangement.	Histidine	216-219	beta-2-microglobulin	Homo sapiens	56-63
6517492-1	1984	A sensitive, accurate method has been established for the assay of serum carnosinase by measuring the fluorescence emitted from the L-histidine liberated on treatment with o-phthaldialdehyde.	Histidine	132-143	carnosine dipeptidase 1	Homo sapiens	67-84
7522258-3	1994	The analysis indicated that residues 144 (tryptophan) and 147 (histidine) were the TCR binding sites and that residues 145 (leucine) and 148 (proline) were important for MHC class II (IAs) binding.	Histidine	63-72	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	83-86
20599753-12	2010	The active site of the catalytic domain of GBBH is similar to that of other 2KG oxygenases, and Fe(II)-binding residues form a conserved His-X-Asp-X(n)-His triad, which is found in all related enzymes.	Histidine	137-140	gamma-butyrobetaine hydroxylase 1	Homo sapiens	43-47
20388494-2	2010	A pair of mutation-sensitive and highly conserved histidines in the sixth transmembrane domain (TM6) of DMT1 was found to be important for proton-metal ion cotransport.	Histidine	50-60	solute carrier family 11 member 2	Homo sapiens	104-108
20388494-13	2010	The specific "alpha-helix-extended segment-alpha-helix" structure of TM6 may have an important implication for the binding of the transporter to H(+) and metal ions and the conformation change induced by the mutations of two highly conserved histidines may be correlated to the deficiency of the transport activity of DMT1.	Histidine	242-252	solute carrier family 11 member 2	Homo sapiens	318-322
6092873-3	1984	Bacteria of strain TK610 uvrA-6 his-4 umuC-36, when allowed to replicate their DNA for some hours after irradiation show induction of His+ mutations when subsequently exposed to visible light.	Histidine	32-35	DNA polymerase V subunit UmuC	Escherichia coli	38-42
20302943-5	2010	Both soluble renalase forms have been purified to homogeneity exploiting their N-terminal His-tag.	Histidine	90-93	renalase, FAD dependent amine oxidase	Homo sapiens	13-21
7520873-4	1994	It has been assessed by comparison with 1H NMR data on the ionization behaviour of the six histidine residues in LIF, the imidazolium pKa values of which range from 3.6 to 7.4.	Histidine	91-100	LIF interleukin 6 family cytokine	Homo sapiens	113-116
8170953-4	1994	This sequence is similar to the Arg-His-Gly-Xaa-Arg* sequence of the distantly related acid phosphatases, which catalyze as BPGM similar phosphoryl transfers but to a greater extent.	Histidine	36-39	bisphosphoglycerate mutase	Homo sapiens	124-128
6636168-6	1983	The same mechanism was suggested for hemolysis caused by T-2 toxin on the basis of the additional following observations: (1) darkness inhibited hemolysis; (2) specific free radical scavengers, i.e., vitamin E, mannitol, and histidine, inhibited hemolysis caused by T-2 toxin.	Histidine	225-234	brachyury 2	Rattus norvegicus	57-60
8004636-5	1994	Investigations of site-directed mutagenesis of the histidine residues of human pancreatic alpha-amylase support this identification.	Histidine	51-60	amylase alpha 2A	Homo sapiens	79-103
20304780-5	2010	The activated DJ-1 functions as a cysteine protease with Cys-106 and His-126 as the catalytic diad.	Histidine	69-72	Parkinsonism associated deglycase	Homo sapiens	14-18
7512983-4	1994	Two severe cases have the same mutation, K10-R156:C, at a conserved arginine that we previously showed was mutated to a histidine in two unrelated EH families.	Histidine	120-129	keratin 10	Homo sapiens	41-44
6625608-0	1983	Is the onset of actin histidine methylation under development control in the chick embryo.	Histidine	22-31	actin, beta	Gallus gallus	16-21
7511204-5	1994	P58, expressed as a histidine fusion protein in Escherichia coli, blocked both the autophosphorylation of PKR and phosphorylation of the alpha subunit of eIF-2.	Histidine	20-29	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	106-109
7511204-5	1994	P58, expressed as a histidine fusion protein in Escherichia coli, blocked both the autophosphorylation of PKR and phosphorylation of the alpha subunit of eIF-2.	Histidine	20-29	eukaryotic translation initiation factor 2 subunit beta	Homo sapiens	154-159
20130963-5	2010	After purification with Ni-NTA His-Bind resin, the yield of recombinant lactoferrin was 17 mg l(-1) with purity of 92.1%, and that of lactoferrin N-lobe was 20 mg l(-1) with purity of 98.5%.	Histidine	31-34	lactotransferrin	Mus musculus	72-83
6625608-9	1983	Thus, in the chick embryo, contrary to those reports published earlier, it was found that actin histidine methylation is not under developmental control.	Histidine	96-105	actin, beta	Gallus gallus	90-95
6311172-5	1983	Spectroscopic measurements of pKa values for Lys-55 (horse and tuna cytochromes c) and His-33 and His-39 (C. krusei and S. cerevisiae cytochromes c) are in excellent agreement with expectations based on chemical-modification studies of horse cytochrome c.	Histidine	87-90	cytochrome c, somatic	Equus caballus	242-254
20439756-2	2010	The crystal structure of apo UCHL1 showed that the active-site residues are not aligned in a canonical form, with the nucleophilic cysteine being 7.7 A from the general base histidine, an arrangement consistent with an inactive form of the enzyme.	Histidine	174-183	ubiquitin C-terminal hydrolase L1	Homo sapiens	29-34
8132589-11	1994	These results confirm that histidine 118 is the critical residue for NDPK-B activity.	Histidine	27-36	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	69-75
8026990-5	1994	A26.4 (A*2603) was different from the other A26 splits at three positions: 74 histidine, 76 valine, and 77 aspartate.	Histidine	78-87	immunoglobulin kappa variable 6-21 (non-functional)	Homo sapiens	0-3
6135456-3	1983	Data from protein photooxidation in the presence of methylene blue and the type of pH-dependence of pKm suggest that glutamate binding takes place on the imidazole ring of the histidine molecule.	Histidine	176-185	pyruvate kinase M1/2	Homo sapiens	100-103
7508181-5	1994	Using direct sequencing of PCR-amplified genomic DNA, we have identified mutations in six families, in which five mutations occur in the beginning of the 1A rod domain of keratin 10-namely, two ARg10 to His, one Arg10 to Cys, and Asn8 to His, and a Tyr14 to Asp.	Histidine	203-206	keratin 10	Homo sapiens	171-181
20351192-2	2010	An N-terminally His-tagged C1inhDelta97 variant was also produced.	Histidine	16-19	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	27-39
6187370-2	1983	Filaggrin is a histidine-rich, cationic protein that aggregates with keratin filaments in vitro and may function as the keratin matrix protein in the terminally differentiated cells of the epidermis.	Histidine	15-24	filaggrin	Homo sapiens	0-9
20044482-3	2010	Hexahistidine-tagged rat TRPV4 (His-rTRPV4) was solubilized with detergent and purified through affinity chromatography and size-exclusion chromatography.	Histidine	32-35	transient receptor potential cation channel, subfamily V, member 4	Rattus norvegicus	25-30
20044482-3	2010	Hexahistidine-tagged rat TRPV4 (His-rTRPV4) was solubilized with detergent and purified through affinity chromatography and size-exclusion chromatography.	Histidine	32-35	transient receptor potential cation channel, subfamily V, member 4	Rattus norvegicus	36-42
20044482-4	2010	Chemical cross-linking analysis revealed that detergent-solubilized His-rTRPV4 was a tetramer.	Histidine	68-71	transient receptor potential cation channel, subfamily V, member 4	Rattus norvegicus	72-78
8198697-3	1994	Based on the histidine-hexapeptide moiety, the recombinant CENP-B was purified to homogeneity by single-step affinity chromatography using metal chelating matrix.	Histidine	13-22	centromere protein B	Homo sapiens	59-65
6633518-6	1983	Two of the peptides of the 11K complex appear to be derived from the 19K fragment of the ceruloplasmin molecule (18); one peptide in the complex appears to correspond to the aspartic acid-rich portion, residues 7-30, and the other to the histidine-rich portion, residues 103-157.	Histidine	238-247	ceruloplasmin	Homo sapiens	89-102
8169525-2	1994	A single base pair substitution of a guanine for cytosine in codon 183 of exon 5 of the LPL gene results in a change of histidine to glutamine in the mature enzyme protein.	Histidine	120-129	lipoprotein lipase	Homo sapiens	88-91
8300604-0	1994	The role of histidine 265 in antagonist binding to the neurokinin-1 receptor.	Histidine	12-21	tachykinin receptor 1	Rattus norvegicus	55-76
6216475-6	1982	The Thr at position 55 in plasminogen (plasmin) Tochigi may perturb His-57 such that the proton transfers associated with the normal catalytic process cannot occur in the abnormal plasmin.	Histidine	68-71	plasminogen	Bos taurus	26-33
8300604-6	1994	In contrast to the human neurokinin-1 receptor, both histidine 197 and histidine 265 in the rat neurokinin-1 receptor appear to interact with both CP-96,345 and RP67580.	Histidine	53-62	tachykinin receptor 1	Rattus norvegicus	96-117
8288565-0	1994	1H NMR study of the solution molecular and electronic structure of engineered distal myoglobin His64(E7) Val/Val68(E11) His double mutant.	Histidine	95-98	myoglobin	Homo sapiens	85-94
8288565-2	1994	A genetically engineered human myoglobin (Mb) in which the distal His, His64(E7), and the distal Val, Val68(E11), are replaced by Val and His, respectively, has been expressed in Escherichia coli, for the purpose of assessing the potential role of a E11 residue in providing a hydrogen bond donor to the coordinated ligand.	Histidine	66-69	myoglobin	Homo sapiens	31-40
7779406-5	1994	The 1H chemical shifts of the 12 conserved aromatic residues and the pKa values of the five conserved histidine residues in MH35 and human LIF are very similar.	Histidine	102-111	LIF interleukin 6 family cytokine	Homo sapiens	139-142
7506493-4	1993	In this article, we studied the regulation by histamine of histidine decarboxylase (HDC) activity (enzyme responsible for the formation of histamine by decarboxylation of L-histidine) in a fraction of isolated rabbit gastric mucosal cells enriched in mucous and endocrine cells.	Histidine	171-182	histidine decarboxylase	Oryctolagus cuniculus	59-82
7506493-4	1993	In this article, we studied the regulation by histamine of histidine decarboxylase (HDC) activity (enzyme responsible for the formation of histamine by decarboxylation of L-histidine) in a fraction of isolated rabbit gastric mucosal cells enriched in mucous and endocrine cells.	Histidine	171-182	histidine decarboxylase	Oryctolagus cuniculus	84-87
7804366-4	1993	The data showed that a single amino acid substitution of tyrosine by phenylalanine and a number of amino acids including serine, asparagine, histidine and arginine at position 97 in the VH CDR3 region all resulted in approximate 18-fold lower binding affinity, whereas the substitution of tyrosine by phenylalanine at position 96 in the VH CDR3 region did not affect the binding affinity of the cB72.3m4 antibody.	Histidine	141-150	cerebellar degeneration-related 3	Mus musculus	189-193
8371339-7	1993	A sequence encoding six consecutive histidines was added to the A1L ORF, which was then incorporated into the genome of a baculovirus expression vector.	Histidine	36-46	late transcription factor VLTF-2	Vaccinia virus	64-67
8234904-9	1993	Hedgehog PP exhibits only 2 unique amino acid substitutions, at positions 1 (Val) and 19 (His), when compared with other mammalian analogues.	Histidine	90-93	pancreatic prohormone	Erinaceus europaeus	9-11
8102366-0	1993	Identification of serine 624, aspartic acid 702, and histidine 734 as the catalytic triad residues of mouse dipeptidyl-peptidase IV (CD26).	Histidine	53-62	dipeptidylpeptidase 4	Mus musculus	108-131
8102366-0	1993	Identification of serine 624, aspartic acid 702, and histidine 734 as the catalytic triad residues of mouse dipeptidyl-peptidase IV (CD26).	Histidine	53-62	dipeptidylpeptidase 4	Mus musculus	133-137
8344434-1	1993	Mouse IgG1, IgG2a, and IgG2b proteins have been selectively labeled with 13C at the carbonyl carbon of His, Met, Trp or Tyr residue and used to prepare the corresponding Fc fragments by limited proteolysis.	Histidine	103-106	immunoglobulin heavy variable V1-9	Mus musculus	12-17
8343114-1	1993	Reaction of human GSH transferase P1-1 (GSTP1-1) with diethylpyrocarbonate (DEPC) at pH 7.0 and 4 degrees C resulted in covalent modification of an equivalent of one histidine and one tyrosine residue per subunit, with loss of activity.	Histidine	166-175	glutathione S-transferase pi 1	Homo sapiens	40-47
8506324-1	1993	The infrared spectra of CO bound to human myoglobin and myoglobin mutants at positions His-64, Val-68, Asp-60, and Lys-45 on the distal side have been measured between 100 and 300 K. Large differences are observed with mutations at His-64 and Val-68 as well as with temperature and pH.	Histidine	87-90	myoglobin	Homo sapiens	56-65
8439557-4	1993	Rabbit CEase (RCEase) retains the active-site serine (gxsxg), the active-site histidine and the tentative heparin binding site (KKRCLQ) at similar positions in comparison to pancreatic CEases of other species.	Histidine	78-87	carboxyl ester lipase	Homo sapiens	7-12
8432848-4	1993	The mAb had nearly identical VH gene sequences; H8 differed from H238 and H161 by a single nucleotide in FR1 that resulted in a histidine for glutamine substitution.	Histidine	128-137	aldo-keto reductase family 1, member B8	Mus musculus	105-108
8380576-2	1993	In the present study, the single-site hEGF mutants Tyr13--&gt;His, Tyr22--&gt;Asp, Ile23--&gt;Thr, and Leu26--&gt;Gly were genetically combined with the Leu47--&gt;Ala hEGF mutant to produce a series of double-site mutant hEGF gene products having alterations simultaneously at two sites, in separate domains, within the same hEGF molecule.	Histidine	62-65	epidermal growth factor	Homo sapiens	38-42
8380576-3	1993	Similarly, the combination of the single-site hEGF mutants Tyr13--&gt;His and Ile23--&gt;Thr generated a double-site mutant having two mutations within the same domain.	Histidine	70-73	epidermal growth factor	Homo sapiens	46-50
8380334-0	1993	Roles of proximal ligand in heme proteins: replacement of proximal histidine of human myoglobin with cysteine and tyrosine by site-directed mutagenesis as models for P-450, chloroperoxidase, and catalase.	Histidine	67-76	myoglobin	Homo sapiens	86-95
8380334-1	1993	Histidine-93(F8) in human myoglobin (Mb), which is the proximal ligand of the heme iron, has been replaced with cysteine or tyrosine by site-directed mutagenesis.	Histidine	0-9	myoglobin	Homo sapiens	26-35
1295893-0	1992	Modification of pig liver dimeric dihydrodiol dehydrogenase with diethylpyrocarbonate and by rose bengal-sensitized photooxidation: evidence for an active-site histidine residue.	Histidine	160-169	trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Sus scrofa	26-59
1453445-1	1992	Myoglobin extracted from the triturative stomach of Dolabella auricularia, a common mollusc found on the Japanese coast, possesses naturally occurring substitution at the distal E7 position (Val-E7) and its oxygen affinity is only slightly lower than those of the common mammalian myoglobins possessing the usual His-E7.	Histidine	313-316	myoglobin	Homo sapiens	0-9
1429680-5	1992	Ubp2 (1,264 residues), Ubp3 (912 residues), and the previously cloned Ubp1 (809 residues) are largely dissimilar except for two short regions containing Cys and His which encompass their putative active sites.	Histidine	161-164	ubiquitin-specific protease UBP2	Saccharomyces cerevisiae S288C	0-4
1512262-5	1992	In the R-state, His-97 beta 2 is positioned between Thr-38 alpha 1 and Thr-41 alpha 1, whereas in transition to the T-state His 97 beta 2 must "jump" a turn in the alpha 1 C helix to form nonpolar contacts with Thr-41 alpha 1 and Pro-44 alpha 1.	Histidine	16-19	adrenoceptor alpha 1D	Homo sapiens	59-66
1512262-5	1992	In the R-state, His-97 beta 2 is positioned between Thr-38 alpha 1 and Thr-41 alpha 1, whereas in transition to the T-state His 97 beta 2 must "jump" a turn in the alpha 1 C helix to form nonpolar contacts with Thr-41 alpha 1 and Pro-44 alpha 1.	Histidine	16-19	adrenoceptor alpha 1D	Homo sapiens	78-85
1512262-5	1992	In the R-state, His-97 beta 2 is positioned between Thr-38 alpha 1 and Thr-41 alpha 1, whereas in transition to the T-state His 97 beta 2 must "jump" a turn in the alpha 1 C helix to form nonpolar contacts with Thr-41 alpha 1 and Pro-44 alpha 1.	Histidine	16-19	adrenoceptor alpha 1D	Homo sapiens	78-85
1512262-5	1992	In the R-state, His-97 beta 2 is positioned between Thr-38 alpha 1 and Thr-41 alpha 1, whereas in transition to the T-state His 97 beta 2 must "jump" a turn in the alpha 1 C helix to form nonpolar contacts with Thr-41 alpha 1 and Pro-44 alpha 1.	Histidine	16-19	adrenoceptor alpha 1D	Homo sapiens	78-85
1512262-5	1992	In the R-state, His-97 beta 2 is positioned between Thr-38 alpha 1 and Thr-41 alpha 1, whereas in transition to the T-state His 97 beta 2 must "jump" a turn in the alpha 1 C helix to form nonpolar contacts with Thr-41 alpha 1 and Pro-44 alpha 1.	Histidine	16-19	adrenoceptor alpha 1D	Homo sapiens	78-85
1512262-7	1992	In the R2-state, His-97 beta 2 simply rotates away from threonines 38 alpha 1 and 41 alpha 1, breaking contact with these residues and allowing water access to the center of the alpha 1 beta 2 interface.	Histidine	17-20	adrenoceptor alpha 1D	Homo sapiens	70-92
1512262-7	1992	In the R2-state, His-97 beta 2 simply rotates away from threonines 38 alpha 1 and 41 alpha 1, breaking contact with these residues and allowing water access to the center of the alpha 1 beta 2 interface.	Histidine	17-20	adrenoceptor alpha 1D	Homo sapiens	70-77
1495962-0	1992	Coregulation of purine and histidine biosynthesis by the transcriptional activators BAS1 and BAS2.	Histidine	27-36	Pho2p	Saccharomyces cerevisiae S288C	93-97
1495962-2	1992	The transcription factors BAS1 and BAS2/PHO2, which are also regulators of the histidine pathway, participate in the regulation of the purine biosynthetic pathway.	Histidine	79-88	Pho2p	Saccharomyces cerevisiae S288C	35-39
1495962-2	1992	The transcription factors BAS1 and BAS2/PHO2, which are also regulators of the histidine pathway, participate in the regulation of the purine biosynthetic pathway.	Histidine	79-88	Pho2p	Saccharomyces cerevisiae S288C	40-44
1441742-6	1992	Recognition by the toxin requires the presence in EF-2 of the unique post-translationally modified histidine derivative, diphthamide.	Histidine	99-108	elongation factor 2	Saccharomyces cerevisiae S288C	50-54
1376415-4	1992	Reactions with single replacement analogs of the RAHEV sequence showed that immunodominant (unreplaceable) residues for the MAbs GPA33 and OSK4-1 were His and Glu, respectively, whereas no such residue was found for the MAb GPA105.	Histidine	151-154	glycoprotein A33	Homo sapiens	129-134
1577716-2	1992	Recent studies have shown that a protein-bound heme adduct formed from the reaction of BrCCl3 with myoglobin was due to bonding of the proximal histidine residue through the ring I vinyl of a heme-CCl2 moiety.	Histidine	144-153	C-C motif chemokine ligand 2	Homo sapiens	197-201
1374249-10	1992	It is concluded that the epitope for this antibody is Phe-Arg-His-Ser-Ser-Phe, which lies at positions 380-385 in rat CYP1A1.	Histidine	62-65	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	118-124
1600556-18	1992	The groups with pKa 7.0 and 6.5 on Torpedo nAChR can be tentatively identified as His residues, whereas those with pKa 5.6 and 4.7 on mouse receptor as Glu or Asp residues.	Histidine	82-85	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	43-48
1543499-0	1992	Multi-functional roles of a histidine residue in human pancreatic alpha-amylase.	Histidine	28-37	amylase alpha 2A	Homo sapiens	55-79
1543499-1	1992	Functional roles of histidine residues at the active site in human pancreatic alpha-amylase were examined by protein engineering.	Histidine	20-29	amylase alpha 2A	Homo sapiens	67-91
1370813-9	1992	Structural comparison of serine proteases (i.e. acyl-amino acid hydrolase or prolyl endopeptidase) with the most conserved domain of THAM identified a stretch of 200 amino acids containing a putative catalytic triad arranged in a novel topological order (Ser-624, Asp-702, and His-734) thereby defining a subfamily of nonclassical serine proteases.	Histidine	277-280	dipeptidylpeptidase 4	Mus musculus	133-137
1362860-2	1992	The deduced amino acid sequence shows a high degree of identity to LPL from other species, and contains the Ser/His/Asp triade characteristic of serine proteases and esterases.	Histidine	112-115	lipoprotein lipase	Homo sapiens	67-70
1552831-1	1992	The synthetic hexapeptide, His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 (GHRP, Growth Hormone-Releasing Peptide), has no structural similarities with any of the GH-releasing peptides known and its action in releasing GH is by a complementary but yet not clearly defined action on the pituitary as well as hypothalamus.	Histidine	27-30	ghrelin and obestatin prepropeptide	Homo sapiens	60-64
1552831-1	1992	The synthetic hexapeptide, His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 (GHRP, Growth Hormone-Releasing Peptide), has no structural similarities with any of the GH-releasing peptides known and its action in releasing GH is by a complementary but yet not clearly defined action on the pituitary as well as hypothalamus.	Histidine	27-30	ghrelin and obestatin prepropeptide	Homo sapiens	66-98
1660880-1	1991	Recombinant human myoglobin mutants with the distal histidine residue replaced by Leu, Val, or Gln residues have been prepared by site-directed mutagenesis and expression in Escherichia coli.	Histidine	52-61	myoglobin	Homo sapiens	18-27
1932123-2	1991	Functional domains like the catalytic triad (His-70, Asp-124, Ser-222) are highly conserved not only between the available acrosin primary structures of different mammals but also in comparison with other serine proteinases.	Histidine	45-48	acrosin	Rattus norvegicus	123-130
1910315-2	1991	Histidine partially abolished the Co2+ inhibition of the iron-dependent lipid peroxidation.	Histidine	0-9	complement C2	Homo sapiens	34-37
2033048-1	1991	To mimic the active sites (Trp-Cys-Gly-His-Cys) contained in two thioredoxin-like domains of the eukaryotic enzyme protein disulfide-isomerase (PDI, EC 5.3.4.1), the Pro-34 residue of Escherichia coli thioredoxin (Trx) was replaced by His using site-directed mutagenesis.	Histidine	39-42	protein-disulfide isomerase	Escherichia coli	115-142
1897979-0	1991	Site-directed mutagenesis of glutathione S-transferase YaYa: nonessential role of histidine in catalysis.	Histidine	82-91	hematopoietic prostaglandin D synthase	Rattus norvegicus	29-54
1897979-2	1991	In order to examine the catalytic role of histidine in the glutathione S-transferase Ya homodimer, site-directed mutagenesis was used to replace all three histidine residues (at positions 8, 143, and 159) by other amino acid residues.	Histidine	42-51	hematopoietic prostaglandin D synthase	Rattus norvegicus	59-84
1908917-2	1991	NIK-244 injected intraarterially into the isolated preparations showed dose-related negative chronotropic, negative inotropic, and coronary vasodilator effects, which are comparable to those of flecainide, and it also showed a dose-related negative dromotropic effect on both atrio-His (AH) and His-ventricular (HV) conduction.	Histidine	282-285	mitogen-activated protein kinase kinase kinase 14	Homo sapiens	0-3
20360762-3	2010	We describe procedures (i) for obtaining genetically modified sensors that are fully functional and suitable for AFM analysis, i.e., elongated Wsc1 derivatives terminated with a His-tag, and (ii) for detecting and stretching single Wsc1 sensors on the surface of living S. cerevisiae cells, using AFM tips functionalized with Ni(2+)-NTA groups.	Histidine	178-181	Slg1p	Saccharomyces cerevisiae S288C	232-236
20376793-7	2010	RESULTS: A novel missense mutation, CAC to CGC, was found at codon 283 of the ABCD1 gene from the patient, resulting in the replacement of histidine by arginine.	Histidine	139-148	ATP binding cassette subfamily D member 1	Homo sapiens	78-83
20113314-8	2010	Substituting the histidine residue at position 3 in human hepcidin-25 and comparably the asparagine residue at position 3 in murine hepcidin-25 with an alanine residue markedly diminished the affinity for copper.	Histidine	17-26	hepcidin antimicrobial peptide	Homo sapiens	58-66
20025906-5	2010	Conserved residues in the predicted transmembrane domains II, IV, V and VII of LIT1 are essential for iron transport in yeast, including histidines that were proposed to function as metal ligands in ZIP transporters.	Histidine	137-147	phosphatidylinositol 4,5-bisphosphate-binding protein	Saccharomyces cerevisiae S288C	79-83
20029090-7	2010	Furthermore, the MVC inhibition is mediated by His-142, suggesting that this residue is protonated for maximal HDAC8 activity.	Histidine	47-50	histone deacetylase 8	Homo sapiens	111-116
19925783-5	2010	Reversible binding of CYP2C9 via an engineered His tag to a phospholipid bilayer was facilitated using nickel-chelating lipids, presenting potential applications for biosensor technologies.	Histidine	47-50	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	22-28
19679188-3	2010	In this study, recombinant methods were used to produce substantial quantities of his-tagged recombinant mouse zeta-crystallin, which was then purified to homogeneity.	Histidine	4-7	crystallin, zeta	Mus musculus	111-126
19940144-9	2010	A conserved histidine in mammalian alpha1(III) at A1 may have prevented 3-hydroxylation because this site in chicken type III was fully hydroxylated, and tyrosine replaced histidine.	Histidine	12-21	adrenoceptor alpha 1D	Homo sapiens	35-52
19940144-9	2010	A conserved histidine in mammalian alpha1(III) at A1 may have prevented 3-hydroxylation because this site in chicken type III was fully hydroxylated, and tyrosine replaced histidine.	Histidine	172-181	adrenoceptor alpha 1D	Homo sapiens	35-52
19906646-7	2010	This property is likely caused by histidine residues in the vicinity of the mapped heparin binding site and could be important for the proposed adhesive function of APL-1.	Histidine	34-43	acireductone dioxygenase 1	Homo sapiens	165-170
19793363-2	2010	Since, in patients with ccTGA(SLL), an elongated His-bundle runs medially toward the upper septum to the site of the fibrous continuity between the right-sided mitral valve and pulmonary artery, the His-bundle may easily be captured by a pacing lead, unlike in normal hearts.	Histidine	49-52	solute carrier family 35 member B2	Homo sapiens	30-33
19793363-2	2010	Since, in patients with ccTGA(SLL), an elongated His-bundle runs medially toward the upper septum to the site of the fibrous continuity between the right-sided mitral valve and pulmonary artery, the His-bundle may easily be captured by a pacing lead, unlike in normal hearts.	Histidine	199-202	solute carrier family 35 member B2	Homo sapiens	30-33
19778616-2	2010	The amino acid sequence of Rv2613c contained a histidine triad (HIT) motif consisting of H-phi-H-phi-H-phi-phi, where phi is a hydrophobic amino acid.	Histidine	47-56	AP-4-A phosphorylase	Mycobacterium tuberculosis H37Rv	27-34
19481969-3	2010	The imidazole ring of histidine captures the Cd ions from the solution, and prevents the growth of the CdS nanoparticles.	Histidine	22-31	CDP-diacylglycerol synthase 1	Homo sapiens	103-106
19481969-5	2010	CdS nanoparticles synthesized using histidine as organic chelating agent have band edge emission at approximately 481 nm and have greater photoluminescence intensity with blue-shift to higher energy due to typical quantum confinement effect.	Histidine	36-45	CDP-diacylglycerol synthase 1	Homo sapiens	0-3
19791753-2	2009	MitoNEET also binds a unique three-Cys- and one-His-ligated [corrected] [2Fe-2S] cluster.	Histidine	48-51	CDGSH iron sulfur domain 1	Homo sapiens	0-8
19559727-7	2009	The soluble Fab fragments, expressed in Escherichia coli were purified by a single step Nickel-NTA affinity chromatography via a hexa-histidine tag and their binding specificities to rabies virus were confirmed.	Histidine	134-143	FA complementation group B	Homo sapiens	12-15
19875047-7	2009	The utility of this class of ligands was further demonstrated by the radiolabelling of a cyclic peptide that is known to target the serine protease receptor uPAR; essentially quantitative incorporation of (99m)Tc occurred exclusively at the SAAC site, despite the presence of a His residue, and without disruption of the disulfide bond.	Histidine	278-281	plasminogen activator, urokinase receptor	Homo sapiens	157-161
19786583-0	2009	Inhibition of K(Ca)2.2 and K(Ca)2.3 channel currents by protonation of outer pore histidine residues.	Histidine	82-91	potassium calcium-activated channel subfamily N member 2	Homo sapiens	14-22
19786583-0	2009	Inhibition of K(Ca)2.2 and K(Ca)2.3 channel currents by protonation of outer pore histidine residues.	Histidine	82-91	potassium calcium-activated channel subfamily N member 3	Homo sapiens	27-35
19786583-5	2009	K(Ca)2.2 and K(Ca)2.3 subunits both possess a histidine residue in their outer pore region between the transmembrane S5 segment and the pore helix, with K(Ca)2.3 also exhibiting an additional histidine residue between the selectivity filter and S6.	Histidine	46-55	potassium calcium-activated channel subfamily N member 2	Homo sapiens	0-8
19786583-5	2009	K(Ca)2.2 and K(Ca)2.3 subunits both possess a histidine residue in their outer pore region between the transmembrane S5 segment and the pore helix, with K(Ca)2.3 also exhibiting an additional histidine residue between the selectivity filter and S6.	Histidine	46-55	potassium calcium-activated channel subfamily N member 3	Homo sapiens	13-21
19786583-5	2009	K(Ca)2.2 and K(Ca)2.3 subunits both possess a histidine residue in their outer pore region between the transmembrane S5 segment and the pore helix, with K(Ca)2.3 also exhibiting an additional histidine residue between the selectivity filter and S6.	Histidine	192-201	potassium calcium-activated channel subfamily N member 2	Homo sapiens	0-8
19786583-5	2009	K(Ca)2.2 and K(Ca)2.3 subunits both possess a histidine residue in their outer pore region between the transmembrane S5 segment and the pore helix, with K(Ca)2.3 also exhibiting an additional histidine residue between the selectivity filter and S6.	Histidine	192-201	potassium calcium-activated channel subfamily N member 3	Homo sapiens	13-21
19786583-7	2009	The greater sensitivity of K(Ca)2.3 currents to protons arose from the additional histidine residue in the pore, which was more proximal to the conduction pathway and in the electrostatic vicinity of the ion conduction pathway.	Histidine	82-91	potassium calcium-activated channel subfamily N member 3	Homo sapiens	27-35
19786583-8	2009	The decrease of channel conductance by extracellular protons was mimicked by mutation of the outer pore histidine in K(Ca)2.2 to an asparagine residue.	Histidine	104-113	potassium calcium-activated channel subfamily N member 2	Homo sapiens	117-125
19707690-2	2009	Here we highlight a crucial role of a basic amino acid triad the entrance of the heme pocket in rHSA (Arg-114, His-146, Lys-190) for O(2) and CO binding to the prosthetic Fe(2+)PP group.	Histidine	111-114	CD24 molecule	Rattus norvegicus	96-100
19487247-1	2009	An N-terminal domain histidine [corresponding to position 39 of UDP-glucuronosyltransferase (UGT) 1A1] is conserved in all UGT1A and UGT2B subfamily proteins except UGT1A4 (Pro-40) and UGT2B10 (Leu-34).	Histidine	21-30	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	165-171
19487247-1	2009	An N-terminal domain histidine [corresponding to position 39 of UDP-glucuronosyltransferase (UGT) 1A1] is conserved in all UGT1A and UGT2B subfamily proteins except UGT1A4 (Pro-40) and UGT2B10 (Leu-34).	Histidine	21-30	UDP glucuronosyltransferase family 2 member B10	Homo sapiens	185-192
19487247-5	2009	The conserved N-terminal domain histidine of UGT1A1, UGT1A6, UGT1A9, and UGT2B7 was mutated to proline and leucine 34 of UGT2B10 was substituted with histidine, and the capacity of the wild-type and mutant proteins to glucuronidate 4MU, 1NP, LTG, TFP, and naproxen was characterized.	Histidine	32-41	UDP glucuronosyltransferase family 2 member B10	Homo sapiens	121-128
19487247-5	2009	The conserved N-terminal domain histidine of UGT1A1, UGT1A6, UGT1A9, and UGT2B7 was mutated to proline and leucine 34 of UGT2B10 was substituted with histidine, and the capacity of the wild-type and mutant proteins to glucuronidate 4MU, 1NP, LTG, TFP, and naproxen was characterized.	Histidine	150-159	UDP glucuronosyltransferase family 2 member B10	Homo sapiens	121-128
19399589-3	2009	Here, we show in human, mouse and sheep airway membranes, that the phosphorylation state of membrane-bound NDPK on histidine and serine residues differs dependent on many regulatory factors.	Histidine	115-124	cytidine/uridine monophosphate kinase 2	Homo sapiens	107-111
19728931-6	2009	In this study, mouse FADD (80-205) containing DD domain and C-terminal region, designated as C-FADD, was expressed in E. coli with His-tag at the N-terminus and purified by Ni2+ affinity chromatography.	Histidine	131-134	Fas (TNFRSF6)-associated via death domain	Mus musculus	21-25
19580301-5	2009	Calculation of the complete series of alkaline earth/histidine complexes confirms the increasing stability of the SB conformations relative to CS with increasing metal ion size, as well as showing that among SB conformations the most highly chelated conformation (SB3) is favored for small metals, whereas the most extended conformation (SB1) is favored for large metals.	Histidine	53-62	SH3KBP1 binding protein 1	Homo sapiens	338-341
19389703-1	2009	This report addresses the functional role of His residues in the proton-coupled folate transporter (PCFT; SLC46A1), which mediates intestinal folate absorption.	Histidine	45-48	solute carrier family 46 member 1	Homo sapiens	100-104
19388667-2	2009	It exhibits a novel protein fold, and in contrast to other 2Fe-2S proteins such as Rieske proteins and ferredoxins, the metal clusters in the mitoNEET homodimer are each coordinated by one histidine residue and three cysteine residues.	Histidine	189-198	CDGSH iron sulfur domain 1	Homo sapiens	142-150
19346561-2	2009	Like other alpha-oxamine synthase subfamily enzymes, SPT is different from most of the fold type I enzymes in that its re face of the PLP-Lys aldimine is occupied by a His residue (His(159)) instead of an aromatic amino acid residue.	Histidine	168-171	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	53-56
19346561-2	2009	Like other alpha-oxamine synthase subfamily enzymes, SPT is different from most of the fold type I enzymes in that its re face of the PLP-Lys aldimine is occupied by a His residue (His(159)) instead of an aromatic amino acid residue.	Histidine	181-184	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	53-56
19344784-5	2009	Pretreatment of host cells with P21-His(6) inhibited cell invasion by extracellular amastigotes from G and CL strains.	Histidine	36-39	H3 histone pseudogene 16	Homo sapiens	32-35
19382167-3	2009	The C-terminus of Vif contains a conserved His-X(5)-Cys-X(17-18)-Cys-X(3-5)-His (HCCH) motif that binds zinc and interacts with Cul5.	Histidine	43-46	cullin 5	Homo sapiens	128-132
19382167-3	2009	The C-terminus of Vif contains a conserved His-X(5)-Cys-X(17-18)-Cys-X(3-5)-His (HCCH) motif that binds zinc and interacts with Cul5.	Histidine	76-79	cullin 5	Homo sapiens	128-132
18448192-2	2009	Triticain alpha, beta and gamma were constituted with 461, 472 and 365 amino acid residues, respectively, and had Cys-His-Asn catalytic triads as well as signal and propeptide sequences.	Histidine	118-121	oryzain alpha chain	Triticum aestivum	0-15
18952607-5	2008	A direct interaction was indicated by in vitro pull-down assay, in which S-His-RASA3 preferentially bound guanosine 5"-O-(gamma-thio)triphosphate-activated Galphai3 and Galphai2 compared with guanosine 5"-O-(beta-thio)diphosphate-inactivated proteins.	Histidine	75-78	G protein subunit alpha i2	Rattus norvegicus	169-177
18848840-7	2008	Compared with individuals carrying genotypes of hOGG1 326Cys/Cys and hMYH 324His/His at the same time, there was a 0.33-fold (OR(adj), 0.33; 95% CI: 0.15-0.72; P&lt;0.05) decreased risk of CBP for those with genotypes of hOGG1 326Ser/Cys+Ser/Ser and hMYH 324His/Gln+Gln/Gln.	Histidine	77-80	8-oxoguanine DNA glycosylase	Homo sapiens	48-53
18848840-7	2008	Compared with individuals carrying genotypes of hOGG1 326Cys/Cys and hMYH 324His/His at the same time, there was a 0.33-fold (OR(adj), 0.33; 95% CI: 0.15-0.72; P&lt;0.05) decreased risk of CBP for those with genotypes of hOGG1 326Ser/Cys+Ser/Ser and hMYH 324His/Gln+Gln/Gln.	Histidine	77-80	8-oxoguanine DNA glycosylase	Homo sapiens	221-226
19261968-0	2008	Leptin influences histidine dipeptides and nitric oxide release from anterior pituitary cells of sheep in vitro.	Histidine	18-27	leptin	Ovis aries	0-6
19568996-8	2008	The mutation was present in a critical region of the COX1 gene, the V374M change being close to the two histidine residues His376 and His378 co-ordinating with the heme a and a (3), and His367 which co-ordinates a magnesium ion.	Histidine	104-113	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	53-57
21836246-4	2008	Among the other amino acids, histidine is most efficient in quenching the emission of the CdS nanoparticles.	Histidine	29-38	CDP-diacylglycerol synthase 1	Homo sapiens	90-93
18557974-0	2008	A proline-to-histidine mutation in POU1F1 is associated with production traits in dairy cattle.	Histidine	13-22	POU class 1 homeobox 1	Bos taurus	35-41
18557974-5	2008	An SNP in exon 3 of POU1F1 that changes a proline to a histidine was identified.	Histidine	55-64	POU class 1 homeobox 1	Bos taurus	20-26
18728031-10	2008	However, unlike thrombopoietin, butyzamide did not react with murine Mpl and was shown to require the histidine residue in the transmembrane domain of Mpl for its agonistic activity.	Histidine	102-111	myeloproliferative leukemia virus oncogene	Mus musculus	151-154
18680512-2	2008	The isotypic residues at position 1101-1106 of the C4A gene contain the Pro-Cys-Pro-Val-Leu-Asp sequence which has a higher affinity for binding amino group-containing antigens, while C4B contains the Leu-Ser-Pro-Val-Ileu-His sequence which has a higher affinity for hydroxyl group-containing antigens.	Histidine	222-225	complement C4A (Rodgers blood group)	Homo sapiens	51-54
1908917-6	1991	Our results suggest that NIK-244 may be a more powerful and longer-lasting antiarrhythmic agent than flecainide, since the antiarrhythmic action of class I drugs is considered to result from inhibition of the fast inward current, which is the most important depolarizing current responsible for the intraatrial and His-Purkinje-ventricular conduction.	Histidine	315-318	mitogen-activated protein kinase kinase kinase 14	Homo sapiens	25-28
2012805-1	1991	Mouse nerve growth factor (NGF) is cleaved at a histidine-methionine bond to release an NH2-terminal octapeptide (NGF1-8).	Histidine	48-57	neurotrophin 3	Mus musculus	114-120
1999399-2	1991	In the first approach, comparison of the primary structure of rat pancreatic cholesterol esterase with that of acetylcholinesterase and cholinesterase revealed two conserved histidine residues located at positions 420 and 435.	Histidine	174-183	acetylcholinesterase	Rattus norvegicus	111-131
1993699-6	1991	T. thermophilus MetRS has a zinc finger-like sequence with all the three cysteine residues and a histidine residue.	Histidine	97-106	methionine--tRNA ligase	Thermus thermophilus HB8	16-21
1996961-7	1991	of rC5a inactivated by GBS 7360 showed that the GBS cleaved the rC5a between histidine-67 and lysine-68 near the C-terminus of rC5a.	Histidine	77-86	complement C5	Rattus norvegicus	3-7
1996961-7	1991	of rC5a inactivated by GBS 7360 showed that the GBS cleaved the rC5a between histidine-67 and lysine-68 near the C-terminus of rC5a.	Histidine	77-86	complement C5	Rattus norvegicus	64-68
18797515-7	2008	Both antifungal and membrane-rupturing activities of HRG were enhanced at low pH, and mapped to the histidine-rich region of the protein.	Histidine	100-109	histidine-rich glycoprotein	Mus musculus	53-56
6216475-6	1982	The Thr at position 55 in plasminogen (plasmin) Tochigi may perturb His-57 such that the proton transfers associated with the normal catalytic process cannot occur in the abnormal plasmin.	Histidine	68-71	plasminogen	Bos taurus	39-46
18373493-0	2008	The role of the diphthamide-containing loop within eukaryotic elongation factor 2 in ADP-ribosylation by Pseudomonas aeruginosa exotoxin A. eEF2 (eukaryotic elongation factor 2) contains a post-translationally modified histidine residue, known as diphthamide, which is the specific ADP-ribosylation target of diphtheria toxin, cholix toxin and Pseudomonas aeruginosa exotoxin A. Site-directed mutagenesis was conducted on residues within the diphthamide-containing loop (Leu693-Gly703) of eEF2 by replacement with alanine.	Histidine	219-228	elongation factor 2	Saccharomyces cerevisiae S288C	62-81
1996961-7	1991	of rC5a inactivated by GBS 7360 showed that the GBS cleaved the rC5a between histidine-67 and lysine-68 near the C-terminus of rC5a.	Histidine	77-86	complement C5	Rattus norvegicus	64-68
6294750-2	1982	The presence of receptors, recognized by vasoactive intestinal peptide (VIP) as well as by PHI (a peptide with N-terminal histidine and C-terminal isoleucine amide), was documented in lung membranes from rat, mouse, guinea pig and man by the ability of these receptors, once occupied, to stimulate adenylate cyclase.	Histidine	122-131	glucose-6-phosphate isomerase	Rattus norvegicus	91-94
1915110-0	1991	Intranasal administration of His-D-Trp-Ala-Trp-D-Phe-LysNH2 (growth hormone releasing peptide) increased plasma growth hormone and insulin-like growth factor-I levels in normal men.	Histidine	29-32	ghrelin and obestatin prepropeptide	Homo sapiens	61-93
18640599-1	2008	A genetically engineered porcine myoglobin triple mutant (H64V/V68H/H93A) (VHA-Mb) contains 6 non-axial His residues (His24, His36, His48, His81, His82, and His119) besides two candidate axial His residues (His68 and His97).	Histidine	104-107	myoglobin	Homo sapiens	33-42
6115414-12	1981	It seems possible that glucose-6-phosphate isomerase, triose phosphate isomerase and pyruvate kinase all contain a histidine and a glutamate residue at the active site.	Histidine	115-124	triosephosphate isomerase 1	Sus scrofa	54-80
18577015-8	2008	The nutritional properties of sample showed that enrichment of semolina with MPI had a pronounced effect on lysine, cysteine, arginine, and histidine contents.	Histidine	140-149	mannose phosphate isomerase	Homo sapiens	77-80
1713327-0	1991	Characterization of His-X3-His sites in alpha-helices of synthetic metal-binding bovine somatotropin.	Histidine	20-23	somatotropin	Bos taurus	88-100
1713327-0	1991	Characterization of His-X3-His sites in alpha-helices of synthetic metal-binding bovine somatotropin.	Histidine	27-30	somatotropin	Bos taurus	88-100
1713327-1	1991	Variants of bovine somatotropin have been engineered to contain synthetic metal-binding sites consisting of two solvent-exposed histidines separated by a single turn of an alpha-helix (His-X3-His variants).	Histidine	128-138	somatotropin	Bos taurus	19-31
2049934-1	1991	Comparison of amino acid sequences of the alpha-chain fragment of human C4, C4d, has shown C4A- and C4B-specific sequences at residues 1101-1106 in which the aspartic acid-histidine substitution at position 1106 may be related to the amide and ester bond forming properties of these molecules.	Histidine	172-181	complement C4A (Rodgers blood group)	Homo sapiens	72-79
6970745-4	1981	C4a is devoid of tryptophan, histidine, and carbohydrate.	Histidine	29-38	complement C4A (Rodgers blood group)	Homo sapiens	0-3
2120051-5	1990	The predicted odd protein of 392 amino acids is highly basic and contains four tandem Cys-Cys/His-His zinc finger repeats, consistent with a presumed function for odd as a DNA binding protein and transcriptional regulator.	Histidine	94-97	odd skipped	Drosophila melanogaster	14-17
2120051-5	1990	The predicted odd protein of 392 amino acids is highly basic and contains four tandem Cys-Cys/His-His zinc finger repeats, consistent with a presumed function for odd as a DNA binding protein and transcriptional regulator.	Histidine	94-97	odd skipped	Drosophila melanogaster	163-166
2120051-5	1990	The predicted odd protein of 392 amino acids is highly basic and contains four tandem Cys-Cys/His-His zinc finger repeats, consistent with a presumed function for odd as a DNA binding protein and transcriptional regulator.	Histidine	98-101	odd skipped	Drosophila melanogaster	14-17
2120051-5	1990	The predicted odd protein of 392 amino acids is highly basic and contains four tandem Cys-Cys/His-His zinc finger repeats, consistent with a presumed function for odd as a DNA binding protein and transcriptional regulator.	Histidine	98-101	odd skipped	Drosophila melanogaster	163-166
18263814-1	2008	PURPOSE: A Tyr-to-His (Y402H) sequence variant in the factor H (FH) and factor H-like protein (FHL-1) gene is strongly associated with an increased susceptibility for age-related macular degeneration (AMD).	Histidine	18-21	four and a half LIM domains 1	Homo sapiens	95-100
6256747-6	1980	When the temperature or the hemoglobin concentration was increased (i) several additional histidine resonances in sickle hemoglobin solutions had larger T1-1 values than the corresponding ones in normal hemoglobin and (ii) the differences between the T1-1 values (sickle versus normal hemoglobin) of these histidine resonances as well as that of the beta 2 histidine resonance gradually increased.	Histidine	90-99	CD2 molecule	Homo sapiens	153-157
18370410-2	2008	Here, we address the role of the conserved active site Ser167 residue in human IDO (S167A and S167H variants), which is replaced with a histidine in other mammalian and bacterial TDO enzymes.	Histidine	136-145	indoleamine 2,3-dioxygenase 1	Homo sapiens	79-82
2146491-0	1990	The degradation sequence of adenovirus E1A consists of the amino-terminal tetrapeptide Met-Arg-His-Ile.	Histidine	95-98	macrophage stimulating 1 S homeolog	Xenopus laevis	39-42
2146491-8	1990	In this study, we have used Xenopus laevis oocytes injected with mRNAs encoding altered E1A proteins to show that the amino-terminal tetrapeptide Met-Arg-His-Ile is required for E1A degradation.	Histidine	154-157	macrophage stimulating 1 S homeolog	Xenopus laevis	88-91
2146491-8	1990	In this study, we have used Xenopus laevis oocytes injected with mRNAs encoding altered E1A proteins to show that the amino-terminal tetrapeptide Met-Arg-His-Ile is required for E1A degradation.	Histidine	154-157	macrophage stimulating 1 S homeolog	Xenopus laevis	178-181
18405501-9	2008	Beta globin gene sequentiation showed the CD92 His --&gt; Pro mutation Hb Newcastle in heterocygote condition in patient and her mother.	Histidine	47-50	hemoglobin subunit beta	Homo sapiens	0-11
6256747-6	1980	When the temperature or the hemoglobin concentration was increased (i) several additional histidine resonances in sickle hemoglobin solutions had larger T1-1 values than the corresponding ones in normal hemoglobin and (ii) the differences between the T1-1 values (sickle versus normal hemoglobin) of these histidine resonances as well as that of the beta 2 histidine resonance gradually increased.	Histidine	90-99	CD2 molecule	Homo sapiens	251-255
2395880-4	1990	The differences in covalent binding properties correlate only with amino acid changes between residues 1101 and 1106 (pro-C4 numbering)--namely, Pro-1101, Cys-1102, Leu-1105, and Asp-1106 in C4A and Leu-1101, Ser-1102, Ile-1105, and His-1106 in C4B, which are located in the C4d region of the alpha chain.	Histidine	233-236	complement C4A (Rodgers blood group)	Homo sapiens	191-194
7191473-7	1980	The role of ionization of His-GH1 in the process of oxidation of sperm whale myoglobin is discussed.	Histidine	26-29	somatotropin	Physeter catodon	30-33
2167456-9	1990	They are bis-histidine, as in mammalian cytochrome b5, methionine-histidine, typified by cytochrome c and lysine-histidine, recently recognized by spectroscopic methods in cytochrome f. Here we report the electron paramagnetic resonance and near infrared magnetic circular dichroism spectra of the oxidized state of Ps.	Histidine	13-22	cytochrome b5 type A	Homo sapiens	40-53
2167456-9	1990	They are bis-histidine, as in mammalian cytochrome b5, methionine-histidine, typified by cytochrome c and lysine-histidine, recently recognized by spectroscopic methods in cytochrome f. Here we report the electron paramagnetic resonance and near infrared magnetic circular dichroism spectra of the oxidized state of Ps.	Histidine	66-75	cytochrome b5 type A	Homo sapiens	40-53
1973165-0	1990	Site-directed mutagenesis of arginine 246, glutamic acid 247, and histidine 248 in the eukaryotic transcription factor S-II.	Histidine	66-75	transcription elongation factor A1	Homo sapiens	119-123
1972730-8	1990	Thus, alteration of histidine 264 and/or arginine 265 within the first PPPGHR motif affects the process of signal transduction via CD2, whereas identical mutations in residues at 271-272 or 278-279 were individually without effect.	Histidine	20-29	CD2 molecule	Homo sapiens	131-134
18302339-6	2008	We found that the work of adhesion between PIP 2-bound ezrin and F-actin is substantially larger than that measured between F-actin and ezrin bound to the membrane via the His tag.	Histidine	172-175	ezrin	Homo sapiens	55-60
18302339-6	2008	We found that the work of adhesion between PIP 2-bound ezrin and F-actin is substantially larger than that measured between F-actin and ezrin bound to the membrane via the His tag.	Histidine	172-175	ezrin	Homo sapiens	136-141
18325109-12	2008	CONCLUSION: Based on the results of our mutagenesis study, we conclude that the two histidine residues in close proximity to the chromophore are approximately equal determinants of the blue-shifted fluorescence emission of mTFP1.	Histidine	84-93	mitochondrial fission process 1	Mus musculus	223-228
7407045-4	1980	His-8 plays a central role in the mechanism of interaction of uteroglobin with progesterone.	Histidine	0-3	secretoglobin family 1A member 1	Homo sapiens	62-73
18042043-7	2008	Final proof that the ORF encoded UROS came from the fact that the recombinant protein expressed with an N-terminal histidine-tag was found to have UROS activity.	Histidine	115-124	uroporphyrinogen-III synthase family protein	Arabidopsis thaliana	33-37
18042043-7	2008	Final proof that the ORF encoded UROS came from the fact that the recombinant protein expressed with an N-terminal histidine-tag was found to have UROS activity.	Histidine	115-124	uroporphyrinogen-III synthase family protein	Arabidopsis thaliana	147-151
2355004-4	1990	It was found that the prosthetic heme was modified by a CCl2 moiety derived from BrCCl3 and was covalently bound to histidine residue 93, the normal proximal ligand to the heme-iron.	Histidine	116-125	C-C motif chemokine ligand 2	Homo sapiens	56-60
7350910-1	1980	Conditions were sought to increase the yield of HCN from L-histidine incubated with L-amino acid oxidase (L-amino acid:oxygen oxidoreductase (deaminating), EC 1.4.3.2) from snake venom, and horseradish peroxidase (donor:hydrogen-peroxide oxidoreductase, EC 1.11.1.7).	Histidine	57-68	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	48-51
2110661-11	1990	Strict conservation of only the Cys/His motif is observed between X. laevis and R. catesbeiana TFIIIA.	Histidine	36-39	general transcription factor 3A L homeolog	Xenopus laevis	95-101
2183181-4	1990	By use of a series of deletion mutants of Ski synthesized in an in vitro translation system, two portions in Ski were found to be necessary for the DNA binding of the Ski complex: the N-proximal portion containing a cystein/histidine-rich domain and the C-terminal portion including a region rich in basic amino acids.	Histidine	224-233	SKI proto-oncogene	Homo sapiens	42-45
2183181-4	1990	By use of a series of deletion mutants of Ski synthesized in an in vitro translation system, two portions in Ski were found to be necessary for the DNA binding of the Ski complex: the N-proximal portion containing a cystein/histidine-rich domain and the C-terminal portion including a region rich in basic amino acids.	Histidine	224-233	SKI proto-oncogene	Homo sapiens	109-112
18163536-9	2008	In vivo, the non-His-tagged variant 111 In-[MMA-DOTA-Cys61]-Z HER2:2395-Cys demonstrated appreciably lower liver uptake than its His-tag-containing counterpart.	Histidine	17-20	erb-b2 receptor tyrosine kinase 2	Mus musculus	62-66
18163536-9	2008	In vivo, the non-His-tagged variant 111 In-[MMA-DOTA-Cys61]-Z HER2:2395-Cys demonstrated appreciably lower liver uptake than its His-tag-containing counterpart.	Histidine	129-132	erb-b2 receptor tyrosine kinase 2	Mus musculus	62-66
7350910-2	1980	Small amounts of histidine and high buffer concentrations favored high HCN yields, which reached a maximum of 72%.	Histidine	17-26	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	71-74
7378050-3	1980	Resonances are assigned to the C-2 and C-4 protons of histidine residues in the active site, and it is suggested that five or six histidine residues serve as ligands to the metal ions in each subunit of the enzyme.	Histidine	54-63	complement C2	Homo sapiens	31-34
26619992-5	2008	In this paper HSMD is developed further as applied to the flexible 7-residue surface loop, 304-310 (Gly-His-Gly-Ala-Gly-Gly-Ser) of the enzyme porcine pancreatic alpha-amylase.	Histidine	104-107	amylase alpha 2A	Homo sapiens	151-175
2296580-2	1990	The spectra of deoxy myoglobin at low pH within 6 ms of the pH drop demonstrate that the iron-histidine bond has been ruptured but that the heme is still five-coordinate.	Histidine	94-103	myoglobin	Homo sapiens	21-30
2296580-6	1990	Three different structural changes are detected at low pH: (i) the iron-proximal histidine (F8) bond in ligand-free myoglobin is broken and replaced by a weak-field ligand, (ii) the distal pocket in MbCO is opened, and (iii) protein constraints on the heme group in MbCO are relaxed.	Histidine	81-90	myoglobin	Homo sapiens	116-125
7378050-3	1980	Resonances are assigned to the C-2 and C-4 protons of histidine residues in the active site, and it is suggested that five or six histidine residues serve as ligands to the metal ions in each subunit of the enzyme.	Histidine	54-63	complement C4A (Rodgers blood group)	Homo sapiens	39-42
7378050-3	1980	Resonances are assigned to the C-2 and C-4 protons of histidine residues in the active site, and it is suggested that five or six histidine residues serve as ligands to the metal ions in each subunit of the enzyme.	Histidine	130-139	complement C2	Homo sapiens	31-34
7378050-3	1980	Resonances are assigned to the C-2 and C-4 protons of histidine residues in the active site, and it is suggested that five or six histidine residues serve as ligands to the metal ions in each subunit of the enzyme.	Histidine	130-139	complement C4A (Rodgers blood group)	Homo sapiens	39-42
34962759-3	2022	Upon measuring the tautomer ratios of several histidine residues in myoglobin, we find good agreement with previous 2D NMR data on this protein.	Histidine	46-55	myoglobin	Homo sapiens	68-77
7014359-1	1980	The frequency of UV-induced arg+ and his+ reversions is found to be enhanced by the presence of colicinogenic plasmids Ib-P9 and Ia-CA53 and reduced by the presence of plasmid V-K30.	Histidine	37-40	cellular communication network factor 3	Homo sapiens	119-124
34402126-6	2021	Of the 361 compounds detected in the liver, 41 compounds, including amino acids related to the Cit-arginine (Arg) cycle, argininosuccinic acid, Arg, ornithine, and Cit, as well as gamma aminobutyric acid, glycine, histidine, and nicotinamide adenine dinucleotide were abundant in l-Cit-treated livers.	Histidine	214-223	citron rho-interacting serine/threonine kinase	Homo sapiens	282-285
17644065-1	2007	Endostar, a novel recombinant human endostatin expressed and purified in Escherichia coli with an additional nine-amino acid sequence and forming another his-tag structure, was approved by the SFDA in 2005 for the treatment of non-small-cell lung cancer.	Histidine	154-157	collagen type XVIII alpha 1 chain	Homo sapiens	36-46
17604220-5	2007	In the present work hexameric histidine tagged Faa1p was purified to homogeneity through a two-step process in the presence of 0.1% eta-dodecyl-beta-maltoside following expression at 15 degrees C in Escherichia coli.	Histidine	30-39	long-chain fatty acid-CoA ligase FAA1	Saccharomyces cerevisiae S288C	47-52
287005-0	1979	Complete amino acid sequence of a histidine-rich proteolytic fragment of human ceruloplasmin.	Histidine	34-43	ceruloplasmin	Homo sapiens	79-92
17668007-4	2007	We show that RRM2 binds to RNA in a new way, by using a tryptophan within a conserved SWQLKD motif that resides on helix alpha1, together with amino acids from strand beta2 and a histidine on loop 5.	Histidine	179-188	ribonucleotide reductase regulatory subunit M2	Homo sapiens	13-17
34383999-1	2021	HLA-B*46:64 has one nucleotide change from HLA-B*46:01:01:01 where Histidine (113) is changed to Arginine.	Histidine	67-76	major histocompatibility complex, class I, B	Homo sapiens	0-5
33180-2	1979	Resonances due to histidine C-2 protons were observed over the full pH range for 3 of the residues; such resonances for the remaining 2 histidine residues broadened out as the pH was increased.	Histidine	18-27	complement C2	Homo sapiens	28-31
34672568-1	2021	MitoNEET, a key regulatory protein in mitochondrial energy metabolism, exhibits a uniquely ligated (2Fe-2S) cluster with one histidine and three cysteines.	Histidine	125-134	CDGSH iron sulfur domain 1	Homo sapiens	0-8
17493829-5	2007	Here we report successful tri-cistronic cloning, overexpression and purification of this three-protein complex using a single hexa-histidine tag.	Histidine	131-140	tRNA-Ile (anticodon AAT) 9-1	Homo sapiens	26-29
33180-6	1979	Histidine 105, immediately adjacent to the site of attachment of a heterosaccharide side chain, has a C-2 proton chemical shift and pK that are insensitive to the large alteration in the bulk of the carbohydrate side chain.	Histidine	0-9	complement C2	Homo sapiens	102-105
17559587-2	2007	This allele is identical to the HLA-B*3503 allele except for one point mutation in exon 4 at codon 188 (CAC--&gt;CGC), resulting in an amino acid change from histidine to arginine.	Histidine	158-167	major histocompatibility complex, class I, B	Homo sapiens	32-37
34425475-5	2021	Heating Rh2(AcO)4 -histidine solutions to 40  C (near body temperature) or 95  C accelerated the formation of RhII2(AcO)2(His)2 and RhIII(His)2(AcO) complexes.	Histidine	122-125	Rh associated glycoprotein	Homo sapiens	8-17
34425475-7	2021	In the case of HSA with 16 histidine and one cysteine residues, UV-vis spectroscopy indicates that mono- and di-histidine HSA adducts with Rh2(AcO)4 are formed.	Histidine	27-36	Rh associated glycoprotein	Homo sapiens	139-148
33180-7	1979	The chemical shifts of the C-2 proton of histidine 48 and of the C-4 proton of histidine 80, histidine residues that are close to one another and to another heterosaccharide side chain, show a similar insensitivity.	Histidine	41-50	complement C2	Homo sapiens	27-30
34425475-10	2021	The partial decomposition of Rh2(AcO)4 both through coordination to histidine or to human serum albumin, the most abundant protein in blood plasma, is a factor to consider for its efficacy as a potential anticancer agent.	Histidine	68-77	Rh associated glycoprotein	Homo sapiens	29-38
17454001-4	2007	Analysis of amino acid sequence revealed conserved residues of cysteine, histidine, asparagine, occluding loop pattern, hemoglobinase motif and glutamine of the oxyanion hole characteristic of cathepsin B like proteases (CBL).	Histidine	73-82	Cbl proto-oncogene	Homo sapiens	193-219
33180-7	1979	The chemical shifts of the C-2 proton of histidine 48 and of the C-4 proton of histidine 80, histidine residues that are close to one another and to another heterosaccharide side chain, show a similar insensitivity.	Histidine	79-88	complement C4A (Rodgers blood group)	Homo sapiens	65-68
33180-7	1979	The chemical shifts of the C-2 proton of histidine 48 and of the C-4 proton of histidine 80, histidine residues that are close to one another and to another heterosaccharide side chain, show a similar insensitivity.	Histidine	79-88	complement C4A (Rodgers blood group)	Homo sapiens	65-68
34370447-13	2021	However, the most modified protein, mainly on histidine residues, was filaggrin, a protein that is of low abundance (0.0266 mol %) and rich in histidine.	Histidine	46-55	filaggrin	Homo sapiens	70-79
34370447-13	2021	However, the most modified protein, mainly on histidine residues, was filaggrin, a protein that is of low abundance (0.0266 mol %) and rich in histidine.	Histidine	143-152	filaggrin	Homo sapiens	70-79
617985-3	1977	Biochemical studies of the histidinemic subjects showed elevated histidine levels in urine, CSF, and brain, while in a few urine samples histidine related imidazole compounds were found.	Histidine	27-36	colony stimulating factor 2	Homo sapiens	92-95
34231327-5	2021	Considering Tau and Pi tautomeric forms of histidine (Tau and Pi tautomers are denoted as epsilon and delta, respectively), simulations were performed on two possible isomers of amylin.	Histidine	43-52	microtubule associated protein tau	Homo sapiens	12-15
17339136-0	2007	Effect of surface histidine mutations and their number on the partitioning and refolding of recombinant human granulocyte-colony stimulating factor (Cys17Ser) in aqueous two-phase systems containing chelated metal ions.	Histidine	18-27	colony stimulating factor 3	Homo sapiens	110-147
892988-3	1977	A description is given of the synthesis by fragment condensation of the peptides Glu-Ser-Ser-Ala-Asp-Lys-Phe-Lys-Arg-Gln-His-Met-Asp and Gly-Glu-Ser-Arg-Glu-Ser-Ser-Ala-Asp-Lys-Phe-Lys-Arg-Gln-His-Met-Asp respectively corresponding to the 5-17 and 1-17 amino acid sequences of rat pancreatic ribonuclease.	Histidine	121-124	ribonuclease A family member 1, pancreatic	Rattus norvegicus	281-304
17339136-4	2007	In this work, the effect of surface histidine mutations and their number on the partitioning and refolding of recombinant human granulocyte-colony stimulating factor Cys17Ser variant (rhG-CSF (C17S)) from solubilized inclusion bodies in aqueous two-phase systems polyethylene glycol (PEG)-dextran, containing metal ions, chelated by dye Light Resistant Yellow 2KT (LR Yellow 2KT)-PEG derivative, was investigated.	Histidine	36-45	colony stimulating factor 3	Homo sapiens	128-165
17459427-10	2007	In conclusion, multiple extracellular histidine residues (H107, H109, H215 and H419) and threonine residues of the alpha1 and beta Zn(2+) coordination sites are critical for modulation of the glycine receptor by protons.	Histidine	38-47	adrenoceptor alpha 1D	Homo sapiens	115-130
34124944-6	2021	Random mutagenesis of the SwrB sequence found that a histidine within the transmembrane segment was conditionally required for activity and punctate localization.	Histidine	53-62	swarming motility protein SwrB	Bacillus subtilis	26-30
34163842-6	2021	Both Ru1 and Ru2 contain an extended planar imidazo(4,5-f)(1,10)phenanthroline ligand, as compared to a 2,2"-bipyridine ligand for Ru3, and we show that the presence of the phenanthroline ligand promotes covalent binding to Abeta peptide His residues, and in addition, leads to a pronounced effect on peptide aggregation immediately after photoactivation.	Histidine	238-241	Scm like with four mbt domains 1	Homo sapiens	5-8
34163842-6	2021	Both Ru1 and Ru2 contain an extended planar imidazo(4,5-f)(1,10)phenanthroline ligand, as compared to a 2,2"-bipyridine ligand for Ru3, and we show that the presence of the phenanthroline ligand promotes covalent binding to Abeta peptide His residues, and in addition, leads to a pronounced effect on peptide aggregation immediately after photoactivation.	Histidine	238-241	doublecortin domain containing 2	Homo sapiens	13-16
12962-6	1976	The PMR spectra show that the structured region includes most of the aromatic residues of both histones, at least two histidine residues of H2B and probably histidines 31 and 82 of histone H2A.	Histidine	118-127	H2B clustered histone 21	Homo sapiens	140-143
17455907-9	2007	A full-length DGKepsilon with a C-terminal His tag exhibited substrate specificity similar to that of the other two forms of the enzyme, indicating that the nature and position of the epitope tag did not strongly affect this property.	Histidine	43-46	diacylglycerol kinase epsilon	Homo sapiens	14-24
35429859-3	2022	A water-soluble histidine-modified perylene diimide fluorescent probe was synthesized by a one-step method, and the probe can form supramolecular aggregates in the presence of Cd2+.	Histidine	16-25	CD2 molecule	Homo sapiens	176-179
12155-0	1976	Hydrogen-deuterium exchange in the histidine residues of bovine alpha-lactalbumin.	Histidine	35-44	lactalbumin alpha	Bos taurus	64-81
17510397-1	2007	There is accumulating evidence that histidine triad (HIT) nucleotide-binding protein 1 (HINT1), a member of the evolutionary highly conserved HIT protein super family, is a novel tumor suppressor.	Histidine	36-45	NUBP iron-sulfur cluster assembly factor 1, cytosolic	Homo sapiens	58-86
239749-3	1975	By high resolution NMR one can detect in the pH range 5-8 the C-2 protons of histidines 105, 12, and 119.	Histidine	77-87	complement C2	Homo sapiens	62-65
17210184-5	2007	We constructed the recombinant expression vector pET28a(+)/hALR with a full-length cDNA encoding hALR protein from normal human liver tissue by one-step reverse transcription-polymerase chain reaction and his-tag recognition sequence encoding polyhistidine (6 x His).	Histidine	262-265	growth factor, augmenter of liver regeneration	Homo sapiens	97-101
35450651-0	2022	Novel biocatalytic strategy of levan: His-ELP-intein-tagged protein purification and biomimetic mineralization.	Histidine	38-41	nuclear receptor subfamily 5 group A member 1	Homo sapiens	42-45
239749-5	1975	On the other hand Mn2+ broadens the C-2 proton of His-105 much more than it does those of His-12 and 119.	Histidine	50-53	complement C2	Homo sapiens	36-39
237758-0	1975	Proton-magnetic-resonance spectroscopic study of the histidine residues of bovine alpha-lactalbumin.	Histidine	53-62	lactalbumin alpha	Bos taurus	82-99
35500664-5	2022	Based on the analysis of the intricately broadened shapes of the MAS NMR peaks observed for isotopically 13C-labeled His-50 of alphaSyn, we show that the distribution of the alphaSyn conformation is skewed from the initial completely random state to a loose beta-rich ensembles at/around His-50 as early as day-3 (d3) within the droplet.	Histidine	117-120	synuclein alpha	Homo sapiens	127-135
35500664-5	2022	Based on the analysis of the intricately broadened shapes of the MAS NMR peaks observed for isotopically 13C-labeled His-50 of alphaSyn, we show that the distribution of the alphaSyn conformation is skewed from the initial completely random state to a loose beta-rich ensembles at/around His-50 as early as day-3 (d3) within the droplet.	Histidine	117-120	synuclein alpha	Homo sapiens	174-182
35500664-5	2022	Based on the analysis of the intricately broadened shapes of the MAS NMR peaks observed for isotopically 13C-labeled His-50 of alphaSyn, we show that the distribution of the alphaSyn conformation is skewed from the initial completely random state to a loose beta-rich ensembles at/around His-50 as early as day-3 (d3) within the droplet.	Histidine	288-291	synuclein alpha	Homo sapiens	127-135
35500664-5	2022	Based on the analysis of the intricately broadened shapes of the MAS NMR peaks observed for isotopically 13C-labeled His-50 of alphaSyn, we show that the distribution of the alphaSyn conformation is skewed from the initial completely random state to a loose beta-rich ensembles at/around His-50 as early as day-3 (d3) within the droplet.	Histidine	288-291	synuclein alpha	Homo sapiens	174-182
35429681-8	2022	Histidine intake increased extracellular histamine concentration around the prefrontal cortex (PFC) and the basal forebrain (BF), leading to a robust increase in the number of c-fos-positive cells around these areas.	Histidine	0-9	FBJ osteosarcoma oncogene	Mus musculus	176-181
17194704-8	2007	The ferric state of the AHSP/alpha-Hb complex shows hexacoordination even at atmospheric pressures, indicating a His-Fe-His binding scheme as previously observed in neuroglobin and cytoglobin.	Histidine	113-116	alpha hemoglobin stabilizing protein	Homo sapiens	24-28
17194704-8	2007	The ferric state of the AHSP/alpha-Hb complex shows hexacoordination even at atmospheric pressures, indicating a His-Fe-His binding scheme as previously observed in neuroglobin and cytoglobin.	Histidine	120-123	alpha hemoglobin stabilizing protein	Homo sapiens	24-28
17355802-2	2007	This study was to express and purify His-hIDO fusion protein and to generate rabbit anti-human IDO polyclonal antibody, which was used to analyze IDO expression in tumor cells.	Histidine	37-40	indoleamine 2,3-dioxygenase 1	Homo sapiens	42-45
17182859-4	2007	This was validated by binding in vitro of both purified full-length HIS-tagged GCP6 and a GCP6(1397-1819) fragment to keratins, and pull-down with native IFs.	Histidine	68-71	tubulin gamma complex associated protein 6	Homo sapiens	79-83
17190829-8	2007	Moreover, a kinetic analysis of purified His(6)-tagged RHM2-N protein revealed 5.9-fold higher affinity of RHM2 for UDP-D-glucose than for dTDP-D-glucose, the preferred substrate for dTDP-D-glucose 4,6-dehydratase from bacteria.	Histidine	41-44	NAD-dependent epimerase/dehydratase family protein	Arabidopsis thaliana	55-59
17164245-0	2007	Electron nuclear double resonance differentiates complementary roles for active site histidines in (6-4) photolyase.	Histidine	85-95	6-4 photolyase	Xenopus laevis	100-115
17164245-5	2007	Shifts in the hyperfine couplings as a function of structural modifications induced by point mutations and pH changes distinguish the protonation states of two highly conserved histidines, His(354) and His(358), in Xenopus laevis (6-4) photolyase.	Histidine	177-187	6-4 photolyase	Xenopus laevis	231-246
17164245-5	2007	Shifts in the hyperfine couplings as a function of structural modifications induced by point mutations and pH changes distinguish the protonation states of two highly conserved histidines, His(354) and His(358), in Xenopus laevis (6-4) photolyase.	Histidine	189-192	6-4 photolyase	Xenopus laevis	231-246
17164245-5	2007	Shifts in the hyperfine couplings as a function of structural modifications induced by point mutations and pH changes distinguish the protonation states of two highly conserved histidines, His(354) and His(358), in Xenopus laevis (6-4) photolyase.	Histidine	202-205	6-4 photolyase	Xenopus laevis	231-246
16908189-6	2007	Addition of both the long and short N-terminal his-tags slows the refolding kinetics of FKBP-12.	Histidine	47-50	FKBP prolyl isomerase 1A pseudogene 4	Homo sapiens	88-95
17040910-4	2006	Four conserved residues in the C-terminal loop of DPP8 (Phe(822), Val(833), Tyr(844), and His(859)), corresponding to those located at the dimer interface of DPP-IV, were individually mutated to Ala.	Histidine	90-93	dipeptidyl peptidase 4	Homo sapiens	158-164
17023418-6	2006	The differential binding of AhR by Arnt and Arnt2 can be ascribed to a single His/Pro amino acid difference in the PASB region of Arnt and Arnt2, suggesting that the PASB/PASB interaction between bHLH-PAS transcription factors plays a selective role for their specific partner molecule.	Histidine	78-81	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	35-39
17023418-6	2006	The differential binding of AhR by Arnt and Arnt2 can be ascribed to a single His/Pro amino acid difference in the PASB region of Arnt and Arnt2, suggesting that the PASB/PASB interaction between bHLH-PAS transcription factors plays a selective role for their specific partner molecule.	Histidine	78-81	aryl hydrocarbon receptor nuclear translocator 2	Homo sapiens	44-49
17023418-6	2006	The differential binding of AhR by Arnt and Arnt2 can be ascribed to a single His/Pro amino acid difference in the PASB region of Arnt and Arnt2, suggesting that the PASB/PASB interaction between bHLH-PAS transcription factors plays a selective role for their specific partner molecule.	Histidine	78-81	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	44-48
17023418-6	2006	The differential binding of AhR by Arnt and Arnt2 can be ascribed to a single His/Pro amino acid difference in the PASB region of Arnt and Arnt2, suggesting that the PASB/PASB interaction between bHLH-PAS transcription factors plays a selective role for their specific partner molecule.	Histidine	78-81	aryl hydrocarbon receptor nuclear translocator 2	Homo sapiens	139-144
17157250-0	2006	Histidine phosphorylation of the potassium channel KCa3.1 by nucleoside diphosphate kinase B is required for activation of KCa3.1 and CD4 T cells.	Histidine	0-9	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	61-92
17157250-4	2006	NDPK-B directly binds and activates KCa3.1 by phosphorylating histidine 358 in the carboxyl terminus of KCa3.1.	Histidine	62-71	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	0-6
17078101-5	2006	We found that among GSTT1(+) individuals the DEB-induced SCE level was significantly lower when the EPHX 139 codon was His/Arg rather than His/His.	Histidine	119-122	epoxide hydrolase 1	Homo sapiens	100-104
17105194-5	2006	Herein we report identification of a conserved Mc b5 core 2 packing motif that plays a key role in stabilizing apoprotein conformation in the vicinity of Trp-22, thereby compensating for the presence of Ser at position 71: a pi-stacking interaction between the side chains of Trp-22 and His-15 that is extended by hydrogen bonding between the side chains of His-15, Ser-20, and Glu-11.	Histidine	287-290	cytochrome b5 type A	Homo sapiens	47-52
17105194-5	2006	Herein we report identification of a conserved Mc b5 core 2 packing motif that plays a key role in stabilizing apoprotein conformation in the vicinity of Trp-22, thereby compensating for the presence of Ser at position 71: a pi-stacking interaction between the side chains of Trp-22 and His-15 that is extended by hydrogen bonding between the side chains of His-15, Ser-20, and Glu-11.	Histidine	358-361	cytochrome b5 type A	Homo sapiens	47-52
17087501-2	2006	The sequence of DesA3 is homologous with those of other membrane desaturases, including the presence of the eight-His motif proposed to bind the diiron center active site.	Histidine	114-117	stearoyl-CoA 9-desaturase	Mycobacterium tuberculosis H37Rv	16-21
17042779-2	2006	In order to characterize its enzymatic properties, the soluble form of the recombinant Och1p was expressed in the methylotrophic yeast Pichia pastoris as a secreted protein, after truncation of its transmembrane region and fusion with myc and histidine tags at the C-terminus, and purified using a metal chelating column.	Histidine	243-252	initiation-specific alpha-1,6-mannosyltransferase	Saccharomyces cerevisiae S288C	87-92
16901746-0	2006	Site-specific mutagenesis of the histidine precursor of diphthamide in the human elongation factor-2 gene confers resistance to diphtheria toxin.	Histidine	33-42	eukaryotic translation elongation factor 2	Homo sapiens	81-100
16901746-1	2006	Protein synthesis elongation factor 2 (EF-2) from eukaryotes contains a conserved post-translationally modified histidine residue known as diphthamide.	Histidine	112-121	eukaryotic translation elongation factor 2	Homo sapiens	18-37
16901746-1	2006	Protein synthesis elongation factor 2 (EF-2) from eukaryotes contains a conserved post-translationally modified histidine residue known as diphthamide.	Histidine	112-121	eukaryotic translation elongation factor 2	Homo sapiens	39-43
16963788-2	2006	Analyses with various spectroscopic methods including MALDI-TOF-MS indicated that two axial His residues (His44 and His68) of cytochrome b(5) were protected from the modification by several factors, i.e., limited steric exposure of the axial imidazole to the solvent, the Fe-N(epsilon2) coordination bond, and protonation of the N(delta1) position by forming a hydrogen bond with its immediate surroundings.	Histidine	92-95	cytochrome b5 type A	Homo sapiens	126-141
16769050-2	2006	We have shown that a fragment released from the central histidine/proline-rich (His/Pro-rich) domain of HRGP blocks endothelial cell migration in vitro and vascularization and growth of murine fibrosarcoma in vivo.	Histidine	56-65	histidine-rich glycoprotein	Mus musculus	104-108
16769050-2	2006	We have shown that a fragment released from the central histidine/proline-rich (His/Pro-rich) domain of HRGP blocks endothelial cell migration in vitro and vascularization and growth of murine fibrosarcoma in vivo.	Histidine	80-83	histidine-rich glycoprotein	Mus musculus	104-108
16769050-3	2006	The minimal active HRGP domain exerting the anti-angiogenic effect was recently narrowed down to a 35 amino acid peptide, HRGP330, derived from the His/Pro-rich domain of HRGP.	Histidine	148-151	histidine-rich glycoprotein	Mus musculus	19-23
16769050-3	2006	The minimal active HRGP domain exerting the anti-angiogenic effect was recently narrowed down to a 35 amino acid peptide, HRGP330, derived from the His/Pro-rich domain of HRGP.	Histidine	148-151	histidine-rich glycoprotein	Mus musculus	122-126
16766478-2	2006	Both H oximes (HI-6, HLo-7) and the oxime BI-6 were found to be more efficacious reactivators of VX-inhibited acetylcholinesterase than pralidoxime and obidoxime.	Histidine	15-17	acetylcholinesterase	Rattus norvegicus	110-130
16717093-2	2006	An important feature of the nucleotide exchange is the structural rearrangement of EF-Tu in the EF-Tu.EF-Ts complex caused by insertion of Phe-81 of EF-Ts between His-84 and His-118 of EF-Tu.	Histidine	163-166	Ts translation elongation factor, mitochondrial	Homo sapiens	102-107
16717093-2	2006	An important feature of the nucleotide exchange is the structural rearrangement of EF-Tu in the EF-Tu.EF-Ts complex caused by insertion of Phe-81 of EF-Ts between His-84 and His-118 of EF-Tu.	Histidine	163-166	Ts translation elongation factor, mitochondrial	Homo sapiens	149-154
16717093-2	2006	An important feature of the nucleotide exchange is the structural rearrangement of EF-Tu in the EF-Tu.EF-Ts complex caused by insertion of Phe-81 of EF-Ts between His-84 and His-118 of EF-Tu.	Histidine	174-177	Ts translation elongation factor, mitochondrial	Homo sapiens	102-107
16717093-2	2006	An important feature of the nucleotide exchange is the structural rearrangement of EF-Tu in the EF-Tu.EF-Ts complex caused by insertion of Phe-81 of EF-Ts between His-84 and His-118 of EF-Tu.	Histidine	174-177	Ts translation elongation factor, mitochondrial	Homo sapiens	149-154
16790357-2	2006	To investigate how GluR1-containing AMPA receptors contribute to dendrite morphogenesis, we characterized a mutant form of GluR1 (containing a histidine in the Q/R editing site) with unique electrophysiological properties.	Histidine	143-152	glutamate ionotropic receptor AMPA type subunit 1	Homo sapiens	19-24
16790357-2	2006	To investigate how GluR1-containing AMPA receptors contribute to dendrite morphogenesis, we characterized a mutant form of GluR1 (containing a histidine in the Q/R editing site) with unique electrophysiological properties.	Histidine	143-152	glutamate ionotropic receptor AMPA type subunit 1	Homo sapiens	123-128
16891471-6	2006	However, these cells did undergo apoptosis in response to another form of recombinant TRAIL, histidine-tagged TRAIL, suggesting differing contributions of DR4 and DR5 in the response to these two forms of TRAIL.	Histidine	93-102	TNF receptor superfamily member 10b	Homo sapiens	163-166
16545906-7	2006	The cytosolic fraction was obtained from the cerebral cortical tissue following centrifugation at 100,000 x g for 1h and caspase-9 activity was assayed using Ac-Leu-Glu-His-Asp-amino-4-methyl coumarin, a specific fluorogenic substrate for caspase-9.	Histidine	169-172	caspase 9	Homo sapiens	121-130
16754992-5	2006	Here, Drep-3 was expressed with a C-terminal His tag in Escherichia coli and the protein was purified to homogeneity.	Histidine	45-48	DNA fragmentation factor-related protein 3	Drosophila melanogaster	6-12
16603126-5	2006	ZmPUMP was also used to investigate the importance of a histidine pair present in the second matrix loop of mammalian UCP1 and absent in plant UCPs.	Histidine	56-65	uncoupling protein 1	Homo sapiens	118-122
16647063-0	2006	A critical role for the histidine residues in the catalytic function of acyl-CoA:cholesterol acyltransferase catalysis: evidence for catalytic difference between ACAT1 and ACAT2.	Histidine	24-33	acetyl-CoA acetyltransferase 1	Homo sapiens	72-108
16647063-7	2006	These results demonstrate that the histidine residues located at the active site are very crucial both for the catalytic activity of the enzyme and for distinguishing ACAT1 from ACAT2 with respect to enzyme catalysis and substrate specificity.	Histidine	35-44	acetyl-CoA acetyltransferase 1	Homo sapiens	167-172
16533814-12	2006	Our results provide strong evidence that Fe(II) is the active-site-bound metal critical for DOHH catalysis and that the strictly conserved His-Glu motifs are essential for iron binding and catalysis.	Histidine	139-142	deoxyhypusine hydroxylase	Homo sapiens	92-96
16533814-13	2006	Furthermore, the iron to DOHH stoichiometry and dependence of iron binding on each of the four conserved His-Glu motifs suggest a binuclear iron mediated reaction mechanism, distinct from that of other Fe(II)-dependent protein hydroxylases, such as prolyl 4-hydroxylase or lysyl hydroxylases.	Histidine	105-108	deoxyhypusine hydroxylase	Homo sapiens	25-29
16396634-2	2006	Anti-rCRDH1 phage clones were obtained after four rounds of screening with rCRDH1-coated immunotubes and single positive colonies were further selected with the expressed thioredoxin-His-S tag of the wild-type pET32c.	Histidine	183-186	thioredoxin	Homo sapiens	171-182
16784457-2	2006	A variety of dicarboxylic acid linkers introduced between the alpha-amino group of His(6) and the epsilon-amino group of Lys(10) lead to high-affinity, selective human melanocortin receptor-1 and -5 (hMC1R and hMC5R) antagonists.	Histidine	83-86	melanocortin 1 receptor	Homo sapiens	168-198
16784457-2	2006	A variety of dicarboxylic acid linkers introduced between the alpha-amino group of His(6) and the epsilon-amino group of Lys(10) lead to high-affinity, selective human melanocortin receptor-1 and -5 (hMC1R and hMC5R) antagonists.	Histidine	83-86	melanocortin 1 receptor	Homo sapiens	200-205
16399879-6	2006	RESULTS: Sequence analysis of the Cct5 gene revealed a missense A492G mutation in exon 4 that results in the substitution of a highly conserved histidine for arginine amino acid 147.	Histidine	144-153	chaperonin containing TCP1 subunit 5	Homo sapiens	34-38
16755491-3	2006	The origin of this variant is a mutation in codon 47 (GAC --&gt; CAC) of the alpha2-globin gene, resulting in the replacement of asparagine by histidine during the translation process.	Histidine	143-152	glutaminase	Homo sapiens	54-57
16371355-10	2006	Within a highly conserved motif known to be important for catalysis, human ACSBG2 contains a histidine residue where all other known acyl-CoA synthetases, including mouse and rat ACSBG2, contain an arginine.	Histidine	93-102	acyl-CoA synthetase bubblegum family member 2	Homo sapiens	75-81
16371355-10	2006	Within a highly conserved motif known to be important for catalysis, human ACSBG2 contains a histidine residue where all other known acyl-CoA synthetases, including mouse and rat ACSBG2, contain an arginine.	Histidine	93-102	acyl-CoA synthetase bubblegum family member 2	Rattus norvegicus	179-185
16540079-5	2006	Synthesis and evaluation of LAH mutants provided evidence that the transfection efficiency depends on the number and positioning of histidine residues in the peptide as well as on the pH at which the in-plane to transmembrane transition takes place.	Histidine	132-141	desmoglein 4	Homo sapiens	28-31
16489009-2	2006	We have shown that the antiangiogenic effect of HRGP is dependent on its histidine/proline-rich domain, which needs to be released from the mother protein to exert its effects.	Histidine	73-82	histidine-rich glycoprotein	Mus musculus	48-52
16420561-5	2006	METHODS AND RESULTS: A recombinant VWF substrate containing the ADAMTS-13 cleavage site and a 6X Histidine tag was cleaved by ADAMTS-13 in a dose-dependent manner, generating approximately 7739 Da peptide containing a 6X Histidine tag.	Histidine	97-106	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	126-135
16420561-5	2006	METHODS AND RESULTS: A recombinant VWF substrate containing the ADAMTS-13 cleavage site and a 6X Histidine tag was cleaved by ADAMTS-13 in a dose-dependent manner, generating approximately 7739 Da peptide containing a 6X Histidine tag.	Histidine	221-230	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	64-73
16420561-5	2006	METHODS AND RESULTS: A recombinant VWF substrate containing the ADAMTS-13 cleavage site and a 6X Histidine tag was cleaved by ADAMTS-13 in a dose-dependent manner, generating approximately 7739 Da peptide containing a 6X Histidine tag.	Histidine	221-230	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	126-135
16091957-10	2006	Our data indicate (i) that H(+) coupling in DMT1 serves to increase affinity for Fe(2+) and provide a thermodynamic driving force for Fe(2+) transport and (ii) that His-272 is critical in transducing the effects of H(+) coupling.	Histidine	165-168	solute carrier family 11 member 2	Homo sapiens	44-48
16249174-2	2005	PTOX and AOX are diiron carboxylate proteins, and based on crystal structures of other members of this protein class, a structural model of PTOX has been proposed in which the ligation sphere of the diiron center is composed of six conserved histidine and glutamate residues.	Histidine	242-251	Alternative oxidase family protein	Arabidopsis thaliana	0-4
16249174-2	2005	PTOX and AOX are diiron carboxylate proteins, and based on crystal structures of other members of this protein class, a structural model of PTOX has been proposed in which the ligation sphere of the diiron center is composed of six conserved histidine and glutamate residues.	Histidine	242-251	Alternative oxidase family protein	Arabidopsis thaliana	140-144
16330094-4	2005	rpL23-GFP-His is among the fusion proteins used in our previous study for ribosomal coupling of C-terminally His-tagged green fluorescent protein.	Histidine	10-13	ribosomal protein L23	Mus musculus	0-5
16330094-4	2005	rpL23-GFP-His is among the fusion proteins used in our previous study for ribosomal coupling of C-terminally His-tagged green fluorescent protein.	Histidine	109-112	ribosomal protein L23	Mus musculus	0-5
16330094-6	2005	We therefore purified rpL23-GFP-His, rpL23-His and GFP from E. coli recombinants using affinity, ion exchange and hydrophobic interaction chromatography.	Histidine	32-35	ribosomal protein L23	Mus musculus	22-27
16226749-4	2005	Recombinant histidine-tagged human PCNA can substitute for purified endogenous human PCNA to initiate human chromosomal DNA replication.	Histidine	12-21	proliferating cell nuclear antigen	Homo sapiens	35-39
16226749-4	2005	Recombinant histidine-tagged human PCNA can substitute for purified endogenous human PCNA to initiate human chromosomal DNA replication.	Histidine	12-21	proliferating cell nuclear antigen	Homo sapiens	85-89
16511245-2	2005	However, the products of the two alleles differ by only two amino acids, at heavy-chain residues 114 (His in HLA-B*2704; Asp in HLA-B*2706) and 116 (Asp in HLA-B*2704; Tyr in HLA-B*2706).	Histidine	102-105	major histocompatibility complex, class I, B	Homo sapiens	109-114
16361827-7	2005	This is the first report to characterize AQP2 mutations in Korean patients with autosomal recessive CNDI, and expands the spectrum of AQP2 mutations by reporting two novel mutation, 70Ala (GCC) to Asp (GAC) and 187Arg (CGC) to His (CAC).	Histidine	227-230	aquaporin 2	Homo sapiens	134-138
16177094-6	2005	Interestingly, they differ at the residue corresponding to the thioester-catalytic histidine, as seen in the human C4A and C4B isotypes, suggesting their distinct substrate specificities in the binding reaction of the thioester.	Histidine	83-92	complement C4A (Rodgers blood group)	Homo sapiens	115-126
16095919-3	2005	Pharmacological studies using specific ligands demonstrated a typical opioid profile for the HuMOR-c-myc-his-tag construct, whereas the GFP-HuMOR-c-myc-his-tag receptor was unable to bind opioid drugs.	Histidine	105-108	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	99-104
16176589-3	2005	Serine lipases, acetylcholinesterase, butyrylcholinesterase, and cholesterol esterase belong to a large family of proteins called the alpha/beta-hydrolase fold, and they share the same catalytic machinery as serine proteases in that they have an active site serine residue which, with a histidine and an aspartic or glutamic acid, forms a catalytic triad.	Histidine	287-296	carboxyl ester lipase	Homo sapiens	0-85
16027123-7	2005	Protonation of two histidine residues (His83 and His87) in helix C of hGM-CSF appears to act as a pH-dependent molecular switch to control the interaction with GAGs.	Histidine	19-28	colony stimulating factor 2	Homo sapiens	70-77
16853158-1	2005	Ultrafast protein dynamics of the CO adduct of a myoglobin mutant with the polar distal histidine replaced by a nonpolar valine (H64V) have been investigated by spectrally resolved infrared stimulated vibrational echo experiments and molecular dynamics (MD) simulations.	Histidine	88-97	myoglobin	Homo sapiens	49-58
15958283-14	2005	Rat Bex3 protein can likely bind transition metals through a histidine-rich domain.	Histidine	61-70	brain expressed X-linked 3	Rattus norvegicus	4-8
15919716-2	2005	We have investigated whether Hi+ mobility varies with pHi.	Histidine	29-32	glucose-6-phosphate isomerase	Rattus norvegicus	54-57
15919716-14	2005	One consequence of a decline in Hi+ mobility at low pHi is that it will predispose the myocardium to pHi nonuniformity.	Histidine	32-35	glucose-6-phosphate isomerase	Rattus norvegicus	52-55
15919716-14	2005	One consequence of a decline in Hi+ mobility at low pHi is that it will predispose the myocardium to pHi nonuniformity.	Histidine	32-35	glucose-6-phosphate isomerase	Rattus norvegicus	101-104
19565007-5	2005	A G --&gt; A single nucleotide polymorphism, which causes an arginine (R) to be replaced with histidine (H) at position 131, defines two allotypes which difer in their avidity for complexed human IgG(2) and IgG(3).	Histidine	94-103	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	207-213
15912551-4	2005	The results indicated that the haem of C357M cytochrome P450cam is possibly axially coordinated to a methionine and a histidine, analogously to cytochrome c.	Histidine	118-127	cytochrome c, somatic	Equus caballus	144-156
15952772-6	2005	The implication of His 33 and Glu 104 in the binding site was deduced from the comparison of FTIR data recorded with horse heart and the variant tuna cytochrome c lacking these two amino acids.	Histidine	19-22	cytochrome c, somatic	Equus caballus	150-162
15952772-7	2005	A two-dimensional NMR analysis of the Zn(2+)-binding site in horse heart cytochrome c confirmed that His 33 and residues close to the C terminus are sensitive to Zn(2+) binding.	Histidine	101-104	cytochrome c, somatic	Equus caballus	73-85
35460908-4	2022	In brief, Met and glucose oxidase (GOx) was encapsulated into histidine/zeolitic imidazolate framework-8 (His/ZIF-8), which was followed by coating with Arg-Gly-Asp (RGD) peptides to obtain the desired nanomedicine (Met/GOx@His/ZIF-8~RGD).	Histidine	62-71	SAFB like transcription modulator	Homo sapiens	10-13
35460908-4	2022	In brief, Met and glucose oxidase (GOx) was encapsulated into histidine/zeolitic imidazolate framework-8 (His/ZIF-8), which was followed by coating with Arg-Gly-Asp (RGD) peptides to obtain the desired nanomedicine (Met/GOx@His/ZIF-8~RGD).	Histidine	62-71	SAFB like transcription modulator	Homo sapiens	216-219
35609787-4	2022	Here we investigate how the loss of histidine methyltransferase Hpm1p results in diverse phenotypes, through use of targeted mass spectrometry, growth assays, quantitative proteomics and differential cross-linking mass spectrometry.	Histidine	36-45	protein-histidine N-methyltransferase	Saccharomyces cerevisiae S288C	64-69
34710488-3	2022	We previously provided evidence that rabbit AMPD1 is composed by two HPRG 73 kDa subunits and two 85 kDa catalytic subunits with a dinuclear zinc site with an average of two histidine residues at each metal site.	Histidine	174-183	adenosine monophosphate deaminase 1	Homo sapiens	44-49
34710488-7	2022	RESULTS: The study confirms the presence of a dinuclear zinc site in rabbit AMPD1 and shows that carbethoxylation of His-51 at the N-terminus of the catalytic subunit removes the inhibition of the enzyme by ATP at pH 7.1.	Histidine	117-120	adenosine monophosphate deaminase 1	Homo sapiens	76-81
35225667-9	2022	In this study, we tried to determine the binding epitope of rituximab for CD20 using histidine-tag insertion for epitope mapping (HisMAP) method.	Histidine	85-94	membrane-spanning 4-domains, subfamily A, member 1	Mus musculus	74-78
237758-1	1975	A study of the three histidine residues of bovine alpha-lactalbumin has been made using proton magnetic resonance (PMR) spectroscopy in order to obtain information on their environments in the protein and thereby to test in part the previously proposed structure.	Histidine	21-30	lactalbumin alpha	Bos taurus	50-67
47704-18	1975	Antithrombin III neutralizes the activity of prethrombin-E and thrombin-E; consequently, an active histidine center found in the B1 chain of thrombin is not essential for the binding of antithrombin.	Histidine	99-108	serpin family C member 1	Homo sapiens	0-16
15920280-4	2005	To overcome this problem we attached a signal sequence, as well as an amino-terminal His-tag fusion to the GM-CSF gene.	Histidine	85-88	colony stimulating factor 2	Homo sapiens	107-113
4641712-0	1972	Assignment of the C-2 histidine proton magnetic resonances of ribonuclease-A.	Histidine	22-31	complement C2	Homo sapiens	18-21
15977068-0	2005	GABAA receptor-associated protein (GABARAP) induces apoptosis by interacting with DEAD (Asp-Glu-Ala-Asp/His) box polypeptide 47 (DDX 47).	Histidine	104-107	GABA type A receptor-associated protein	Homo sapiens	0-33
15977068-0	2005	GABAA receptor-associated protein (GABARAP) induces apoptosis by interacting with DEAD (Asp-Glu-Ala-Asp/His) box polypeptide 47 (DDX 47).	Histidine	104-107	GABA type A receptor-associated protein	Homo sapiens	35-42
15977068-0	2005	GABAA receptor-associated protein (GABARAP) induces apoptosis by interacting with DEAD (Asp-Glu-Ala-Asp/His) box polypeptide 47 (DDX 47).	Histidine	104-107	DEAD-box helicase 47	Homo sapiens	129-135
15858043-2	2005	Among these residues, aspartate 92 and histidine 117 are both required for Fv1(b) resistance, whereas the latter is sufficient to confer Ref1 resistance.	Histidine	39-48	Friend virus susceptibility 1	Mus musculus	75-78
34002224-6	2021	We also observed that HLA-DRB1*13 is more than twice as frequent in the modern population, whereas HLA-B alleles encoding an isoleucine at position 80 (I-80+), HLA C*06:02 and HLA-DPB1 alleles encoding histidine at position 9 are half as frequent in the modern population.	Histidine	202-211	major histocompatibility complex, class I, B	Homo sapiens	99-104
15864132-4	2005	HuH7 human hepatoma cells were transfected with vectors encoding for the human Ala- or Val-MnSOD variants fused to a Myc-His-tag.	Histidine	121-124	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	117-120
33978396-0	2021	Histidine Tautomeric Effect on the Key Fragment R3 of Tau Protein from Atomistic Simulations.	Histidine	0-9	microtubule associated protein tau	Homo sapiens	10-13
15802216-10	2005	To overcome the proteolysis by thrombin, C-terminal His-tagged LMP2A NTD and intein-fused LMP2A NTD were prepared.	Histidine	52-55	LMP2A	Human gammaherpesvirus 4	63-68
33978396-3	2021	In the current study, replica-exchange molecular dynamics (REMD) were performed to investigate the effect of histidine tautomerism on the structures of a key fragment (R3) of tau protein and the transformation between different conformations.	Histidine	109-118	microtubule associated protein tau	Homo sapiens	119-122
15766882-5	2005	In this study, we produced a 6 x His-tagged GST-CD38 fusion protein using a recombinant baculovirus/insect cell expression technique that was purified as a soluble protein.	Histidine	33-36	CD38 molecule	Homo sapiens	48-52
33978396-4	2021	Based on the simulation results, we propose the histidine tautomerism hypothesis for tau protein misfolding.	Histidine	48-57	microtubule associated protein tau	Homo sapiens	58-61
33899866-0	2021	Molecular mechanism of amyloidogenicity and neurotoxicity of a pro-aggregated tau mutant in the presence of histidine tautomerism via replica-exchange simulation.	Histidine	108-117	microtubule associated protein tau	Homo sapiens	78-81
15741231-5	2005	Additionally, the triadic His562 residue of LDLR, which is putatively involved in ligand uncoupling, was mutated to Asn, corresponding to Asn643 in LpR, to analyse the role of the His triad in receptor functioning.	Histidine	26-29	low density lipoprotein receptor	Homo sapiens	44-48
33899866-2	2021	Recently, we proposed a histidine tautomerization hypothesis of tau fibrillogenesis for the pathobiology of AD and other neuro diseases.	Histidine	24-33	microtubule associated protein tau	Homo sapiens	34-37
15710513-2	2005	Previous research has shown that biodegradable, multiblock copolymers (MBC), PEG-PLL-g-16% His, are efficient gene carriers with negligible cellular toxicities.	Histidine	91-94	progestagen associated endometrial protein	Homo sapiens	77-80
33693809-0	2021	Human METTL18 is a histidine-specific methyltransferase that targets RPL3 and affects ribosome biogenesis and function.	Histidine	19-28	methyltransferase like 18	Homo sapiens	6-13
15651042-6	2005	By means of DFT (B3LYP, lacv3p**) calculations, we could show that the formation of such a triad is essential to support the proton transfer from selenol to a histidine to stabilise a selenolate anion, which is able to interact with the disulfide of thioredoxin and catalyses the reductive disulfide opening.	Histidine	159-168	thioredoxin	Homo sapiens	250-261
15724202-1	2005	The electron transfer reaction of wild-type myoglobin at an electrode was significantly facilitated in a D2O buffer as compared with that in an H2O buffer, with k(0)"(H2O)/k(0)"(D2O)= 0.13, while a minimal deuterium kinetic isotope effect on the myoglobin with modification at distal histidine (His-64) was observed.	Histidine	295-298	myoglobin	Homo sapiens	44-53
33693809-0	2021	Human METTL18 is a histidine-specific methyltransferase that targets RPL3 and affects ribosome biogenesis and function.	Histidine	19-28	ribosomal protein L3	Homo sapiens	69-73
33693809-6	2021	We found that His-245 in RPL3 carries a 3-methylhistidine (3MH; tau-methylhistidine) modification, which was absent in METTL18 KO cells.	Histidine	14-17	ribosomal protein L3	Homo sapiens	25-29
33693809-6	2021	We found that His-245 in RPL3 carries a 3-methylhistidine (3MH; tau-methylhistidine) modification, which was absent in METTL18 KO cells.	Histidine	14-17	methyltransferase like 18	Homo sapiens	119-126
33693809-7	2021	In addition, both recombinant and endogenous METTL18 were found to be automethylated at His-154, thus further corroborating METTL18 as a histidine-specific MTase.	Histidine	88-91	methyltransferase like 18	Homo sapiens	45-52
33152392-1	2021	We developed a pH-activatable cell-penetrating peptide dimer LH2 with histidine residues, which can penetrate cells, specifically in weak acidic conditions, even at few tens of nanomolar concentrations.	Histidine	70-79	LIM homeobox protein 2	Mus musculus	61-64
15701055-8	2005	The 14-3-3-binding motif Lys-Lys-Glu-Ser-His-Pro (371-376) was detected in the HvNHX2 amino acid sequence, which is suggestive of possible involvement of the 14-3-3 proteins in the regulation of HvNHX2 function.	Histidine	41-44	sodium/proton exchanger	Hordeum vulgare	79-85
15701055-8	2005	The 14-3-3-binding motif Lys-Lys-Glu-Ser-His-Pro (371-376) was detected in the HvNHX2 amino acid sequence, which is suggestive of possible involvement of the 14-3-3 proteins in the regulation of HvNHX2 function.	Histidine	41-44	sodium/proton exchanger	Hordeum vulgare	195-201
33175428-5	2021	Common feature of [ 1 +AA+H] +   complexes is the presence of a protonated AA bound to neutral 1 , in spite of the fact that the gas phase basicity of 1 is comparable to the one of Lys and His.	Histidine	189-192	aspartate beta-hydroxylase	Homo sapiens	23-27
33175428-7	2021	Within [ 1 +AA+H] +   the side chain substituents (imidazole group for His and terminal amino group for Lys) present comparable basic properties as the a-amino group, taking part to a cooperative H-bond network.	Histidine	71-74	aspartate beta-hydroxylase	Homo sapiens	12-16
33167279-8	2021	Then more His-tag can be left on the Au film and a bigger SPR signal could be record, this signal is associated with the concentration of OGT.	Histidine	10-13	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	138-141
33147004-7	2020	The present research will aid in obtaining insight into the organizational and accumulation properties of tau protein in the presence of histidine tautomerism to control AD.	Histidine	137-146	microtubule associated protein tau	Homo sapiens	106-109
33075108-8	2020	The results showed that 2280 His-p30 could directly degrade IFNAR1 RNA but not IFNAR2 RNA.	Histidine	29-32	interferon alpha and beta receptor subunit 1	Homo sapiens	60-66
32865988-0	2020	Differential roles of extracellular Histidine residues of GPR68 for proton-sensing and allosteric modulation by divalent metal ions.	Histidine	36-45	G protein-coupled receptor 68	Homo sapiens	58-63
32576658-5	2020	The catalytic domain displayed a polypeptide fold similar overall to those of other members in the DNA cross-link repair gene SNM1 family and in mRNA 3"-end-processing endonuclease CPSF-73, containing metallo-beta-lactamase and beta-CASP domains and a cluster of conserved histidine and aspartate residues capable of binding two metal atoms in the catalytic site.	Histidine	273-282	DNA cross-link repair 1A	Homo sapiens	126-130
32515247-0	2020	Cardiospecific Overexpression of ATPGD1 (Carnosine Synthase) Increases Histidine Dipeptide Levels and Prevents Myocardial Ischemia Reperfusion Injury.	Histidine	71-80	carnosine synthase 1	Mus musculus	33-39
32522286-12	2020	Rh-CSF1 significantly improved the neurological deficits at 48 h and 4 weeks after HI, which was accompanied by a reduction in the brain infarct area, brain edema, brain atrophy, and neuroinflammation.	Histidine	83-85	colony stimulating factor 1	Homo sapiens	3-7
32522286-14	2020	Inhibition of CSF1R and PLCG2 abolished these neuroprotective effects of rh-CSF1 after HI.	Histidine	87-89	phospholipase C, gamma 2	Rattus norvegicus	24-29
32522286-14	2020	Inhibition of CSF1R and PLCG2 abolished these neuroprotective effects of rh-CSF1 after HI.	Histidine	87-89	colony stimulating factor 1	Homo sapiens	14-18
32522286-15	2020	CONCLUSIONS: Our findings demonstrated that the activation of CSF1R by rh-CSF1 attenuated neuroinflammation and improved neurological deficits after HI.	Histidine	149-151	colony stimulating factor 1	Homo sapiens	62-66
32423671-0	2020	Exploration of dipeptidyl-peptidase IV (DPP IV) inhibitors in a low-molecular mass extract of the earthworm Eisenia fetida and identification of the inhibitors as amino acids like methionine, leucine, histidine, and isoleucine.	Histidine	201-210	dipeptidyl peptidase 4	Homo sapiens	40-46
32029268-4	2020	The oriented immobilization of PNGase F on magnetic particles utilizes the affinity of its co-expressed His-tag towards iminodiacetic acid-Nickel modified magnetic particles.	Histidine	104-107	N-glycanase 1	Homo sapiens	31-37
32433611-6	2020	A structure obtained with oleoyl-CoA substrate resolved at approximately 3.2 A shows that the CoA moiety binds DGAT1 on the cytosolic side and the acyl group lies deep within a hydrophobic channel, positioning the acyl-CoA thioester bond near an invariant catalytic histidine residue.	Histidine	266-275	diacylglycerol O-acyltransferase 1	Homo sapiens	111-116
32696751-5	2020	Then the recombinant plasmid of pcDNA3.4/beta2m-linker 2-HLA A24-His tag was constructed and transfected into Expi293F cells.	Histidine	65-68	alpha-2-macroglobulin	Homo sapiens	41-47
32696751-10	2020	The recombinant plasmids of pcDNA3.4/beta2m-linker 2-HLA A24-His tag was successfully constructed and expressed in the Expi293F cells.	Histidine	61-64	alpha-2-macroglobulin	Homo sapiens	37-43
31678368-4	2020	For studies on characterization of the protein, two different constructs of SOS1 comprising of the residues 28 to 460 and 28 to 990 were cloned and overexpressed in methylotropic yeast strain of Pichia pastoris with a C-terminal histidine tag using the expression vector pPICZA.	Histidine	229-238	sodium proton exchanger, putative (NHX7) (SOS1)	Arabidopsis thaliana	76-80
32392205-5	2020	The differential specificity of ligands to BLT1 and BLT2 is explained by the replacement of histidine with tyrosine.	Histidine	92-101	leukotriene B4 receptor 2	Homo sapiens	52-56
32188384-4	2020	Recently, however, molecular identities of first two distinct histidine-specific protein methyltransferases have been established in yeast (Hpm1) and in metazoan (actin-histidine N-methyltransferase), giving new insights into the phenomenon of protein methylation at histidine sites.	Histidine	62-71	protein-histidine N-methyltransferase	Saccharomyces cerevisiae S288C	140-144
31740583-8	2019	Indeed, histidine 59 in HLA-B*27:03 leads to a series of local conformational changes that act in concert to reduce the accessibility of the nearby cysteine 67, an essential amino acid residue for the formation of HLA-B27 homodimers.	Histidine	8-17	major histocompatibility complex, class I, B	Homo sapiens	24-29
31740583-8	2019	Indeed, histidine 59 in HLA-B*27:03 leads to a series of local conformational changes that act in concert to reduce the accessibility of the nearby cysteine 67, an essential amino acid residue for the formation of HLA-B27 homodimers.	Histidine	8-17	major histocompatibility complex, class I, B	Homo sapiens	214-221
15613086-5	2004	Expressed protein encoded by a carboxy (C)-terminal His-tagged CB2 construct displayed a B(max) value of 9.3 pmol/mg with a K(D) of 7.30 nM using [3(H)]CP-55(940), a standard cannabinoid radioligand, and was selected for subsequent purification experiments.	Histidine	52-55	cannabinoid receptor 2	Homo sapiens	63-66
31384872-3	2019	Here, we report that the presence of a composite non-ELP sequence that includes both His and T7 tags or a short Ser-Lys-Gly-Pro-Gly (SKGPG) sequence can dramatically change the LCST behavior of a positively-charged ELP domain.	Histidine	85-88	nuclear receptor subfamily 5 group A member 1	Homo sapiens	53-56
15564475-7	2004	However, the recognition of this exposed epitope by an anti-HBc antibody appeared to be affected by the I97E mutation or by histidine tagging at the C terminus of mutant HBcAg, which is presumably in the capsid interior.	Histidine	124-133	keratin 88, pseudogene	Homo sapiens	60-63
15375167-5	2004	In silico modeling followed by mutagenesis and the in vitro and cell-based binding studies showed that the His(171)-Glu-Lys-Gln-Ala-Asp(176) and Val(223)-Arg-Asn(224) peptide sequences of MT1-MMP are directly involved in the binding with C1q.	Histidine	107-110	complement C1q A chain	Homo sapiens	238-241
15339918-6	2004	These findings suggest that His(320) is located in the distal heme pocket of OxdA and would donate a proton to the substrate in the aldoxime dehydration mechanism.	Histidine	28-31	D-amino acid oxidase	Homo sapiens	77-81
31384872-3	2019	Here, we report that the presence of a composite non-ELP sequence that includes both His and T7 tags or a short Ser-Lys-Gly-Pro-Gly (SKGPG) sequence can dramatically change the LCST behavior of a positively-charged ELP domain.	Histidine	85-88	nuclear receptor subfamily 5 group A member 1	Homo sapiens	215-218
31463593-1	2019	Diphthamide, the target of diphtheria toxin, is a post-translationally modified histidine residue found in archaeal and eukaryotic translation elongation factor 2 (EF2).	Histidine	80-89	eukaryotic translation elongation factor 2	Homo sapiens	120-162
31463593-1	2019	Diphthamide, the target of diphtheria toxin, is a post-translationally modified histidine residue found in archaeal and eukaryotic translation elongation factor 2 (EF2).	Histidine	80-89	eukaryotic translation elongation factor 2	Homo sapiens	164-167
31032878-8	2019	Low sensitivity of Kv 12.1 and characteristics of quinine-dependent inhibition were determined by histidine 462, as site-directed mutagenesis of this residue into the homologous tyrosine of Kv 11.1 conferred Kv 11.1-like quinine block to Kv 12.1(H462Y).	Histidine	98-107	potassium voltage-gated channel subfamily H member 2	Homo sapiens	190-197
15518569-5	2004	Mutation of His42 (the only His of SOUL) to Ala resulted in loss of heme binding, confirming that this residue is an axial ligand of SOUL.	Histidine	12-15	heme binding protein 2	Mus musculus	35-39
15518569-5	2004	Mutation of His42 (the only His of SOUL) to Ala resulted in loss of heme binding, confirming that this residue is an axial ligand of SOUL.	Histidine	12-15	heme binding protein 2	Mus musculus	133-137
15520806-4	2004	Erf2 and Akr1 are integral membrane proteins that contain a cysteine-rich domain and an Asp-His-His-Cys motif, both of which catalyse acylation at the carboxyl terminus of their target proteins.	Histidine	92-95	palmitoyltransferase ERF2	Saccharomyces cerevisiae S288C	0-4
31032878-8	2019	Low sensitivity of Kv 12.1 and characteristics of quinine-dependent inhibition were determined by histidine 462, as site-directed mutagenesis of this residue into the homologous tyrosine of Kv 11.1 conferred Kv 11.1-like quinine block to Kv 12.1(H462Y).	Histidine	98-107	potassium voltage-gated channel subfamily H member 2	Homo sapiens	208-215
15453723-2	2004	Our new artificial acylase, tert-butyldiphenylsilyl ether of N-(2,4,6-triisopropylbenzenesulfonyl)-pi(Me)-l-histidinol, is a simple and small molecule (molecular weight = 660) that contains only one chiral carbon center that originates from natural l-histidine.	Histidine	249-260	telomerase reverse transcriptase	Homo sapiens	28-32
31267017-4	2019	Conversely, increasing the pH sensitivity of TremeIgG1 by introducing designed tyrosine-to-histidine mutations prevents antibody-triggered lysosomal CTLA-4 downregulation and dramatically attenuates irAE.	Histidine	91-100	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	149-155
15313223-1	2004	In comparison with the amino acid sequences of seven species of glucosyltransferases and six species of galactosyltransferases, glutamine and histidine are highly conserved as the last amino acid residue of a glycosyltransferase-specific conserved region (UDPGT) in glucosyltransferases and galactosyltransferases, respectively.	Histidine	142-151	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	256-261
2777799-6	1989	The distal histidine in this subunit inhibits the bimolecular rate of binding of both O2 and CO, sterically hinders bound CO and methyl isocyanide, and stabilizes bound O2 by hydrogen bonding.	Histidine	11-20	immunoglobulin kappa variable 1D-39	Homo sapiens	86-95
31273433-4	2019	We show here that the SLC30A8 gene is also inactivated in sheep, cows, chinchillas and naked mole rats but in all four species a histidine is retained at amino acid 10 in the B chain of insulin.	Histidine	129-138	LOW QUALITY PROTEIN: zinc transporter 8	Ovis aries	22-29
2605694-1	1989	A heptadecapeptide, H-Arg-Lys-Ala-Val-Tyr-Val-Glu-Leu-Tyr-Leu-Gln-Ser-Leu-Thr-Ala-Glu-His-OH , corresponding to amino acids 32 to 48 of human splenin (hSP) and an analog in which the amino acid residue at position 34 is changed from Ala to Glu, were synthesized.	Histidine	86-89	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	151-154
15218029-4	2004	Pam16 forms a complex with Pam18 and displays similarity to J-proteins but lacks the canonical tripeptide motif His-Pro-Asp (HPD).	Histidine	112-115	presequence translocase associated motor 16	Homo sapiens	0-5
31223255-5	2019	Filaggrin is a multifunctional, histidine-rich, insoluble protein.	Histidine	32-41	filaggrin	Homo sapiens	0-9
15265741-3	2004	To identify novel Hsp90 inhibitors, a highly robust time-resolved fluorescence resonance energy transfer (TR-FRET)-based HTS assay that measures the binding of biotinylated geldanamycin (biotin-GM) to the His-tagged human Hsp90 N-terminal ATP-binding domain (Hsp90N) was developed.	Histidine	205-208	heat shock protein 90 alpha family class A member 1	Homo sapiens	18-23
15265919-10	2004	Taken together, this study shows that surface-exposed histidines mediate the interaction of mast cell tryptase with heparin and are of critical importance in the formation of active tryptase tetramers.	Histidine	54-64	tryptase alpha/beta 1	Mus musculus	102-110
15265919-10	2004	Taken together, this study shows that surface-exposed histidines mediate the interaction of mast cell tryptase with heparin and are of critical importance in the formation of active tryptase tetramers.	Histidine	54-64	tryptase alpha/beta 1	Mus musculus	182-190
2545905-4	1989	The protein predicted by this reading frame (STP; saimiri transformation-associated protein) has a highly hydrophobic stretch of 26 amino acids sufficient for a membrane-spanning domain near its carboxy terminus; this domain is immediately preceded by a sequence appropriate for formation of a metal-binding domain (His X2 His X6 Cys X2 Cys, where Xs are other amino acids).	Histidine	316-319	thyroid hormone receptor interactor 10	Homo sapiens	45-48
30992364-0	2019	Tau repeat regions contain conserved histidine residues that modulate microtubule-binding in response to changes in pH.	Histidine	37-46	microtubule associated protein tau	Homo sapiens	0-3
30992364-4	2019	Here, we used molecular dynamics, microtubule-binding experiments, and live-cell microscopy, revealing that highly-conserved histidine residues near the C terminus of each microtubule-binding repeat are pH sensors that can modulate tau-microtubule interaction strength within the physiological intracellular pH range.	Histidine	125-134	microtubule associated protein tau	Homo sapiens	232-235
2787670-0	1989	The microheterogeneity of desialylated alpha 1-antichymotrypsin: the occurrence of two amino-terminal isoforms, one lacking a His-Pro dipeptide.	Histidine	126-129	serpin family A member 3	Homo sapiens	39-63
15260978-6	2004	The PDE1B structure shows that in dual-specific PDEs a key histidine residue may enable the invariant glutamine to toggle between cAMP and cGMP.	Histidine	59-68	phosphodiesterase 1B	Homo sapiens	4-9
30992364-7	2019	Electrostatic and hydrophobic characteristics of histidine were both required for tau-microtubule binding, as substitutions with constitutively and positively charged nonaromatic lysine or uncharged alanine greatly reduced or abolished tau-microtubule binding.	Histidine	49-58	microtubule associated protein tau	Homo sapiens	82-85
2811897-3	1989	The catalytic His and Asp residues tentatively identified in p14 together with the Ser residue of the GDSGG sequence, presumably, constitute the "catalytic triad" characteristic of chymotrypsin-like proteases.	Histidine	14-17	ribonuclease P/MRP subunit p14	Homo sapiens	61-64
30992364-7	2019	Electrostatic and hydrophobic characteristics of histidine were both required for tau-microtubule binding, as substitutions with constitutively and positively charged nonaromatic lysine or uncharged alanine greatly reduced or abolished tau-microtubule binding.	Histidine	49-58	microtubule associated protein tau	Homo sapiens	236-239
30826286-13	2019	Furthermore, a specific residue difference between CRFR1 subtypes (glutamate) and CRFR2beta (histidine) in this interface region may impair CRFR2beta:RAMP2 interaction by electrostatic repulsion.	Histidine	93-102	receptor activity modifying protein 2	Homo sapiens	150-155
2645140-6	1989	The affinity of the mutant E. coli SSB proteins for single-stranded DNA decreased in the order Trp greater than Phe (wild-type) greater than Tyr greater than Leu greater than His greater than Val greater than Ser, leading to the conclusion that position 60 is a site of hydrophobic interaction of the protein with DNA.	Histidine	175-178	single-stranded DNA-binding protein	Escherichia coli	35-38
30885568-0	2019	New SIRT2 inhibitors: Histidine-based bleomycin spin-off.	Histidine	22-31	sirtuin 2	Homo sapiens	4-9
3199133-1	1988	One equivalent of Fe3+ -mesoporphyrin (heme) is coordinated by two axial histidine ligands to a preferred site on histidine-rich glycoprotein (HRG).	Histidine	73-82	histidine rich glycoprotein	Homo sapiens	114-141
3199133-1	1988	One equivalent of Fe3+ -mesoporphyrin (heme) is coordinated by two axial histidine ligands to a preferred site on histidine-rich glycoprotein (HRG).	Histidine	73-82	histidine rich glycoprotein	Homo sapiens	143-146
15178418-4	2004	To further investigate the drugs metabolized by UGT1A4, the Bac-to-Bac expression system was used to express the recombinant UGT1A4 with His-tag on the C-terminal.	Histidine	137-140	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	48-54
15178418-4	2004	To further investigate the drugs metabolized by UGT1A4, the Bac-to-Bac expression system was used to express the recombinant UGT1A4 with His-tag on the C-terminal.	Histidine	137-140	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	125-131
15149817-3	2004	Folding of cyt c leads to a state having the heme iron coordinated to a histidine (His18) and a methionine (Met80) as axial ligands.	Histidine	72-81	cytochrome c, somatic	Equus caballus	11-16
31149044-8	2019	Though BAP2 contains a weak Michael acceptor, interaction with PDI relies on Histidine 256 in the b" domain of PDI, suggesting allosteric binding.	Histidine	77-86	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	63-66
15144374-4	2004	Here, we show that the N-terminal conserved motif (EFWG) and histidine 25 (H25), a potential catalytic residue, were important for the gene repression activity of HD2A.	Histidine	61-70	histone deacetylase 3	Arabidopsis thaliana	163-167
15078916-9	2004	Alkaline pH increased the water permeability of AQP4 that contains His at position 129 in loop C. Acid and alkaline pH sensitivity was induced in AQP1 by adding histidines 48 (in loop A) and 130 (in loop C).	Histidine	67-70	aquaporin 4	Bos taurus	48-52
15078916-9	2004	Alkaline pH increased the water permeability of AQP4 that contains His at position 129 in loop C. Acid and alkaline pH sensitivity was induced in AQP1 by adding histidines 48 (in loop A) and 130 (in loop C).	Histidine	161-171	aquaporin 4	Bos taurus	48-52
2849988-8	1988	Sequence comparisons of RSKG-7, RSKG-3, and other kallikrein-related enzymes reveal the key amino acid residues needed for both serine protease activity (His/Asp/Ser) and kallikrein-like cleavage specificity at basic amino acids.	Histidine	154-157	kallikrein 1	Rattus norvegicus	24-30
2849988-8	1988	Sequence comparisons of RSKG-7, RSKG-3, and other kallikrein-related enzymes reveal the key amino acid residues needed for both serine protease activity (His/Asp/Ser) and kallikrein-like cleavage specificity at basic amino acids.	Histidine	154-157	kallikrein 1-related peptidase C12	Rattus norvegicus	32-38
3233287-1	1988	Possible interactions of the His-12 ring with other side chain and backbone groups of C-peptide lactone (CPL) are discussed.	Histidine	29-32	hephaestin	Homo sapiens	86-103
3233287-1	1988	Possible interactions of the His-12 ring with other side chain and backbone groups of C-peptide lactone (CPL) are discussed.	Histidine	29-32	hephaestin	Homo sapiens	105-108
3233287-3	1988	The main new conclusion is that in the helical conformation of CPL, the Phe-8 and His-12 rings are clustered together.	Histidine	82-85	hephaestin	Homo sapiens	63-66
3233287-4	1988	Studies of Phe-8----Ala analogs of CPL and calculations of ring current effects satisfactorily explain the observed environmental shifts of Phe-8 and His-12 protons in NMR spectra of CPL.	Histidine	150-153	hephaestin	Homo sapiens	35-38
15604682-9	2004	Both (His)6-ACBP4 and (His)6-ACBP5 bind [14C]oleoyl-CoA with high affinity, [14C]palmitoyl-CoA with lower affinity and did not bind [14C]arachidonyl-CoA.	Histidine	6-9	acyl-CoA binding protein 4	Arabidopsis thaliana	12-17
14715082-3	2004	The present study describes the increased expression of both mRNA and protein for the cyclin-dependent kinase inhibitors p21 and p27 in response to deprivation of HepG2 cells for a single essential amino acid, histidine.	Histidine	210-219	H3 histone pseudogene 16	Homo sapiens	121-124
3233287-4	1988	Studies of Phe-8----Ala analogs of CPL and calculations of ring current effects satisfactorily explain the observed environmental shifts of Phe-8 and His-12 protons in NMR spectra of CPL.	Histidine	150-153	hephaestin	Homo sapiens	183-186
31149044-8	2019	Though BAP2 contains a weak Michael acceptor, interaction with PDI relies on Histidine 256 in the b" domain of PDI, suggesting allosteric binding.	Histidine	77-86	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	111-114
14715082-3	2004	The present study describes the increased expression of both mRNA and protein for the cyclin-dependent kinase inhibitors p21 and p27 in response to deprivation of HepG2 cells for a single essential amino acid, histidine.	Histidine	210-219	interferon alpha inducible protein 27	Homo sapiens	129-132
14715082-5	2004	For p21, increase in mRNA by histidine depletion appeared to be independent of p53 transactivation, and the absolute level of p53 protein was unaffected by this treatment.	Histidine	29-38	H3 histone pseudogene 16	Homo sapiens	4-7
30931977-0	2019	The protonation state of an evolutionarily conserved histidine modulates domainswapping stability of FoxP1.	Histidine	53-62	forkhead box P1	Homo sapiens	101-106
14715082-6	2004	Histidine limitation caused an increase in the phosphorylation of ERK1/ERK2 (extracellular-signal-regulated kinase), and inhibition of the ERK signal transduction pathway resulted in a reduction in the starvation-dependent increase in p21 mRNA.	Histidine	0-9	H3 histone pseudogene 16	Homo sapiens	235-238
15063568-2	2004	Recombinant histidine-tagged SafB chaperone complexed with SafD adhesin was expressed in Escherichia coli and purified.	Histidine	12-21	scaffold attachment factor B	Mus musculus	29-33
2900138-6	1988	T1 is related to TC1, and has the structure: Ser-Ser(P)-Met-Ser-Gly-Leu-His-Leu-Val-Lys.	Histidine	72-75	Serum cholesterol level QTL 22	Rattus norvegicus	17-20
3410637-2	1988	The titration curves of the C-2 histidine protons of bovine pancreatic ribonuclease A in the presence of several dideoxynucleoside monophosphates (dNpdN) were studied by means of proton nuclear magnetic resonance at 270 MHz in order to obtain information on the ligand--RNase A interaction.	Histidine	32-41	complement C2	Bos taurus	28-31
3410637-3	1988	The changes in the chemical shift and pKs of the C-2 proton resonances of His-12, -48, -119 in the complexes RNase A--dNpdN were smaller than those previously found when the enzyme interacted with mononucleotides.	Histidine	74-77	complement C2	Bos taurus	49-52
2962936-4	1988	Protein sequence studies on peptides generated by trypsin digestion of factor H, purified from pooled plasma from 12 donors, confirmed the presence of both tyrosine and histidine at this position.	Histidine	169-178	complement factor H	Homo sapiens	71-79
2962936-5	1988	Tyrosine and histidine were observed in a ratio of 2:1, respectively, and therefore this polymorphism is likely to represent a sequence difference between the two most abundant charge variants, FH1 and FH2, of factor H.	Histidine	13-22	complement factor H	Homo sapiens	210-218
30931977-5	2019	Here, we explore the consequences of the protonation state of another histidine (H59), only conserved within FoxM/O/P subfamilies, on folding and dimerization of the forkhead domain of human FoxP1.	Histidine	70-79	forkhead box P1	Homo sapiens	191-196
2827651-1	1987	We synthesized a hexapeptide, Gly-His-His-Pro-His-Gly, previously identified as a tandem motif in the histidine-rich glycoprotein (HRG) which has multiple heme-binding sites.	Histidine	38-41	histidine rich glycoprotein	Homo sapiens	102-129
30841425-3	2019	The fusion protein His-HSP65-STEAP1 186-193 (HHST1), His-HSP65-2xSTEAP1 186-193 (HHST2) and His-HSP65-6xSTEAP1 186-193 (HHST6) were obtained by setting different copy number of STEAP1 186-193 and adding His purification tag before HSP65.	Histidine	19-22	heat shock protein 1 (chaperonin)	Mus musculus	23-28
2827651-1	1987	We synthesized a hexapeptide, Gly-His-His-Pro-His-Gly, previously identified as a tandem motif in the histidine-rich glycoprotein (HRG) which has multiple heme-binding sites.	Histidine	38-41	histidine rich glycoprotein	Homo sapiens	131-134
3122823-2	1987	The active enzyme contains 227 residues, including three corresponding to the catalytic triad characteristic of serine protease (His-57, Asp-102, and Ser-195 in chymotrypsin).	Histidine	129-132	cell division cycle 34, ubiqiutin conjugating enzyme	Rattus norvegicus	112-127
15001397-4	2004	When cells expressing the recombinant TPI protein with histidine tag were exposed to hypoxia and the TPI protein was affinity-purified, the catalytic activity (specific activity) of the TPI protein purified from hypoxic cells was substantially lower than that obtained from normoxic cells.	Histidine	55-64	triosephosphate isomerase 1	Mus musculus	38-41
15025965-0	2004	[Abnormal expression of fragile histidine triad (FHIT) and Mut S homolog 2 (MSH2) proteins in human sporadic colorectal carcinoma and their clinical significance].	Histidine	32-41	serpin family B member 3	Homo sapiens	100-129
15026177-11	2004	In addition to characterizing catalytic residues, these studies have identified the structural basis (His(156)) for an exploitable difference in the substrate and inhibition kinetics of 3 beta-HSD1 and 3 beta-HSD2.	Histidine	102-105	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	186-213
30598506-3	2019	Here, using immunoprecipitation, subcellular fractionation, His-ubiquitin pulldown, and immunofluorescence microscopy assays, along with siRNA-based knockdown approaches, we demonstrate that ribosomal protein L6 (RPL6) directly interacts with histone H2A and is involved in the DNA damage response (DDR).	Histidine	60-63	ribosomal protein L6	Homo sapiens	191-211
14769043-2	2004	The two thioether bonds linking protein to heme in cyt c are present in 1, and the native axial ligand His-18 remains coordinated to iron.	Histidine	103-106	cytochrome c, somatic	Equus caballus	51-56
3435555-6	1987	It was revealed that polypeptides (Ala-Tyr-Glu)n and (His-Ser-Glu)n possess, in hydrolysis of Z-L-Ala-ONp- and Z-D-Ala-ONp some enantioselectivity with the value of KD/KL 1.3 and 1.17, resp.	Histidine	54-57	KIT ligand	Homo sapiens	168-172
30376305-4	2019	X-ray protein crystallography of the {[Pt(ppy)(PPh3)]/ubiquitin} conjugate revealed direct bonding of the platinum center to unique histidine-68 residue through the nitrogen atom of imidazole function, the coordination being also supported by noncovalent interaction of the ligands with the protein secondary structure.	Histidine	132-141	protein phosphatase 4 catalytic subunit	Homo sapiens	47-51
3305492-11	1987	Acyl-peptide hydrolase appears to be a serine protease utilizing a charge relay system involving serine, histidine, and, probably, a carboxyl group(s).	Histidine	105-114	acylaminoacyl-peptide hydrolase	Rattus norvegicus	0-22
3624221-5	1987	The 1H and 13C nuclear magnetic resonance data indicated that imidazole C-2 of histidine is linked to C-6 of norleucine (epsilon-deaminated lysine residue) which in turn is linked to the C-6 amino group of hydroxylysine.	Histidine	79-88	complement C2	Bos taurus	72-75
14725977-12	2004	These findings indicate that the elevation of histamine H(2) receptor stimulation by massive administration of histidine suppresses reperfusion injury in the brain.	Histidine	111-120	histamine receptor H 2	Rattus norvegicus	46-69
14705189-8	2004	Moreover, the utilization of histidine-immobilized agarose gel effectively concentrated the trace amount of LPS from the C(12)E(10)-solubilized HbV solution and washed out C(12)E(10) as an inhibitory element.	Histidine	29-38	interferon regulatory factor 6	Homo sapiens	108-111
30576128-13	2019	These findings add to the understanding of [2Fe-2S] cluster nitrosylation and will help to identify DNICs resulting from the reaction of NO with Fe/S cofactors featuring alternative, proton-responsive histidine ligands such as the Rieske and mitoNEET [2Fe-2S] clusters.	Histidine	201-210	CDGSH iron sulfur domain 1	Homo sapiens	242-250
3112579-8	1987	All four mutations that altered invariant cysteine or histidine residues led to an adr1 null phenotype.	Histidine	54-63	DNA-binding transcription factor ADR1	Saccharomyces cerevisiae S288C	83-87
30243846-5	2019	The imprints created with cysteine (CME) and histidine modified epitopes (HME) could detect the peptide in a concentration range of 2-128 microM and 15.6 nM to 128 microM, respectively.	Histidine	45-54	L1 cell adhesion molecule	Mus musculus	74-77
2437111-2	1987	Bovine NRP was identified as H-Ile-Ala-Arg-Arg-His-Pro-Tyr-Phe-Leu-OH, which is similar in structure to both neurotensin and angiotensin I. Canine and human NRP also had the above amino acid composition, whereas that obtained from rat plasma had valine substituted for isoleucine.	Histidine	47-50	neurotensin	Bos taurus	109-120
3030432-5	1987	The function of the heme c moieties in the catalytic cycle of the enzyme is discussed on the basis of their homology with the proximal histidine region of peroxidase (horseradish peroxidase and yeast cytochrome-c peroxidase) and cytochromes (horse cytochrome c and Pseudomonas cytochrome c-551).	Histidine	135-144	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	200-223
3548423-1	1987	The human vasoactive intestinal polypeptide (VIP) precursor contains a sequence, a peptide with an N-terminal histidine and C-terminal methionine (PHM), which is 93% homologous to the porcine intestinal peptide, (PHI) a peptide having N-terminal histidine and C-terminal isoleucine amide, suggesting that PHI could be a product of the porcine VIP precursor.	Histidine	246-255	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	147-150
15697091-1	2004	Hemoglobin Q-India is a very rare alpha-chain structural variant caused by the mutation AAG--&gt;GAG (Asp--&gt;His) in the position of codon 64 of the alpha1 gene.	Histidine	111-114	adrenoceptor alpha 1D	Homo sapiens	151-157
14750595-3	2004	Dominant cone-rod dystrophies arising from changes in retGC1 are essentially restricted to mutations in codon 838 and result in the replacement of a conserved arginine residue with either cysteine, histidine or serine.	Histidine	198-207	guanylate cyclase 2D, retinal	Homo sapiens	54-60
20501143-1	1987	Specific binding sites for thyrotropin-releasing hormone (TRH) were labelled with the potent analog, [(3)H] (3-Me-His(2))TRH, in the brain and spinal cord of the mutant mouse spastic and nonafflicted littermate controls.	Histidine	114-117	thyrotropin releasing hormone	Mus musculus	27-56
20501143-1	1987	Specific binding sites for thyrotropin-releasing hormone (TRH) were labelled with the potent analog, [(3)H] (3-Me-His(2))TRH, in the brain and spinal cord of the mutant mouse spastic and nonafflicted littermate controls.	Histidine	114-117	thyrotropin releasing hormone	Mus musculus	58-61
30396406-2	2019	Therefore, the cost-effective production of Saccharomyces cerevisiae Ulp1 protease catalytic domain (402-621 aa) was targeted via its cloning under strong T7 promoter with and without histidine tag.	Histidine	184-193	SUMO protease ULP1	Saccharomyces cerevisiae S288C	69-73
20501143-1	1987	Specific binding sites for thyrotropin-releasing hormone (TRH) were labelled with the potent analog, [(3)H] (3-Me-His(2))TRH, in the brain and spinal cord of the mutant mouse spastic and nonafflicted littermate controls.	Histidine	114-117	thyrotropin releasing hormone	Mus musculus	121-124
3791584-9	1986	Adenosine deaminase also reduced (by 95%) the atria-to-His-bundle interval prolongation in normoxic recipient hearts caused by the effluent of hypoxic donor hearts.	Histidine	55-58	adenosine deaminase	Homo sapiens	0-19
30422655-0	2018	Copper Induced Radical Dimerization of alpha-Synuclein Requires Histidine.	Histidine	64-73	synuclein alpha	Homo sapiens	39-54
3016144-5	1986	However, the tonin activity in hypertensive rats was significantly higher (p less than 0.001) than that in the normotensive rats (His-Leu, 168.7 +/- 10.1 vs. 131.5 +/- 17.3 nmol/min X mg protein).	Histidine	130-133	kallikrein 1-related peptidase C2	Rattus norvegicus	13-18
14532275-8	2003	Protein sequence analysis and homology modeling further verified that MMP-26 has an intermediate S1" pocket formed by Leu-204, His-208, and Tyr-230.	Histidine	127-130	matrix metallopeptidase 26	Homo sapiens	70-76
14532275-11	2003	MMP-26 contains a His-233 that renders the S1" pocket to an intermediate size.	Histidine	18-21	matrix metallopeptidase 26	Homo sapiens	0-6
14662886-4	2003	His-Phe-Tyr-Leu-Pro-Met (HFYLPM) is a synthetic peptide that binds to FPRL1.	Histidine	0-3	formyl peptide receptor 2	Homo sapiens	70-75
12959987-7	2003	However, l-His potentiates cAMP response element reporter activity in INS-1 cells and in human embryonic kidney-293 cells expressing either the GLP-1R alone or the CaSR and GLP-1R.	Histidine	9-14	insulin 1	Rattus norvegicus	70-75
29923593-3	2018	In the present study, the histopathological effect of 200 and 1000 mg/kg of HI methanolic stem bark extract (HlMeOHe) was evaluated in the small bowel, liver, pancreas, kidneys and brain of CD-1 male mice after oral sub-acute treatment for 28 days.	Histidine	76-78	CD1 antigen complex	Mus musculus	190-194
14604533-4	2003	In vitro Sco1 binds copper(I) through a CXXXCP motif and possibly His 135 and copper(II) in two different species, thus suggesting that copper(II) is adventitious more than physiological.	Histidine	66-69	Cu-binding protein SCO1	Saccharomyces cerevisiae S288C	9-13
3877728-10	1985	The unique N-terminal amino acid sequences of both forms of CSF were the same: (Lys-Glu-Val-Ser-Glu-His-X-Ser-His-Met-Ile-Gly-Asn).	Histidine	100-103	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	60-63
3877728-10	1985	The unique N-terminal amino acid sequences of both forms of CSF were the same: (Lys-Glu-Val-Ser-Glu-His-X-Ser-His-Met-Ile-Gly-Asn).	Histidine	110-113	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	60-63
30187212-3	2018	The primary sequence of prothymosin-alpha is highly acidic, with almost 50% comprised of Asp and Glu, and is unusual for a Zn2+-binding protein as it lacks Cys and His residues.	Histidine	164-167	prothymosin alpha pseudogene 9	Homo sapiens	24-41
30044755-0	2018	A single domain antibody against the Cys- and His-rich domain of PCSK9 and evolocumab exhibit different inhibition mechanisms in humanized PCSK9 mice.	Histidine	46-49	proprotein convertase subtilisin/kexin type 9	Mus musculus	65-70
2415656-8	1985	This binding site involves some of the same amino acid side chains, His 435, Tyr 436, and one or both His 433 and 310, and is in the same location as the site that binds SPA.	Histidine	68-71	surfactant protein A2	Homo sapiens	170-173
2415656-8	1985	This binding site involves some of the same amino acid side chains, His 435, Tyr 436, and one or both His 433 and 310, and is in the same location as the site that binds SPA.	Histidine	102-105	surfactant protein A2	Homo sapiens	170-173
14529291-2	2003	Accordingly, we overexpressed human cPLA(2)gamma containing an N-terminal His tag ((His)(6)cPLA(2)gamma) in Sf9 cells and quantitatively solubilized and purified the enzyme by sequential immobilized metal affinity and Mono Q column chromatographies.	Histidine	74-77	phospholipase A2 group IVC	Homo sapiens	36-48
14529291-2	2003	Accordingly, we overexpressed human cPLA(2)gamma containing an N-terminal His tag ((His)(6)cPLA(2)gamma) in Sf9 cells and quantitatively solubilized and purified the enzyme by sequential immobilized metal affinity and Mono Q column chromatographies.	Histidine	74-77	phospholipase A2 group IVC	Homo sapiens	91-103
30044755-0	2018	A single domain antibody against the Cys- and His-rich domain of PCSK9 and evolocumab exhibit different inhibition mechanisms in humanized PCSK9 mice.	Histidine	46-49	proprotein convertase subtilisin/kexin type 9	Mus musculus	139-144
12885787-11	2003	Four residues in the first cysteine-bracketed loop of chi-MrIA and a His in loop 2 played a dominant role in the interaction between chi-MrIA and the NET.	Histidine	69-72	solute carrier family 6 member 2	Rattus norvegicus	150-153
3911093-4	1985	Cathepsin B hydrolyzed angiotensin I via a dipeptidyl carboxypeptidase mechanism removing His-Leu to form angiotensin II, and it degraded angiotensin II as an endopeptidase at the Val3-Tyr4 bond.	Histidine	90-93	cathepsin B	Homo sapiens	0-11
30171282-6	2018	The binding constant (Kd = 0.67 muM) revealed the micromolar sensitivity and high selectivity of the his-tagged GBP biosensor for glucose, making it suitable for TG measurements.	Histidine	101-104	transmembrane protein 132A	Homo sapiens	112-115
4055729-1	1985	The flavoenzymes dimethylglycine dehydrogenase (EC 1.5.99.2) and sarcosine dehydrogenase (EC 1.5.99.1) contain covalently bound FAD linked via the 8 alpha-position of the isoalloxazine ring to the imidazole N(3) of a histidine residue (Cook, R. J., Misono, K. S., and Wagner, C. (1984) J. Biol.	Histidine	217-226	dimethylglycine dehydrogenase	Rattus norvegicus	17-46
12917459-6	2003	Among three amino acid differences (positions 60, 61 and 63) in this region, histidine 61 present in human SLAM was most significant, but combined substitutions with this residue and one or both of isoleucine 60 and valine 63 increased further the receptor activity of mouse SLAM.	Histidine	77-86	signaling lymphocytic activation molecule family member 1	Mus musculus	275-279
12914946-5	2003	However, the catalytic triad of Cys-His-Glu is not strictly conserved in DJ-1, implying that DJ-1 has a different catalytic mechanism if it acts as a protease or DJ-1 serves as a regulatory protein in the physiological processes.	Histidine	36-39	Parkinsonism associated deglycase	Homo sapiens	93-97
12914946-5	2003	However, the catalytic triad of Cys-His-Glu is not strictly conserved in DJ-1, implying that DJ-1 has a different catalytic mechanism if it acts as a protease or DJ-1 serves as a regulatory protein in the physiological processes.	Histidine	36-39	Parkinsonism associated deglycase	Homo sapiens	93-97
3840230-9	1985	Each of these regions contains the presumed active site sequence Trp-Cys-Gly-His-Cys-Lys, suggesting that PDI, similar in action to thioredoxin, catalyses disulphide bond interchange via an internal disulphide-sulphydryl interchange.	Histidine	77-80	prolyl 4-hydroxylase subunit beta	Rattus norvegicus	106-109
3018536-2	1985	A strain containing his3-delta 13, an allele which deletes the upstream promoter element but contains the TATA box and intact structural gene, fails to express the gene and consequently is unable to grow in medium lacking histidine.	Histidine	222-231	imidazoleglycerol-phosphate dehydratase HIS3	Saccharomyces cerevisiae S288C	20-24
30187685-1	2018	HLA-B*40:06:07 has one synonymous nucleotide change from HLA-B*40:06:01:01 at nucleotide 81 (codon 3 histidine).	Histidine	101-110	major histocompatibility complex, class I, B	Homo sapiens	0-5
4041423-6	1985	Indirect evidence is adduced that the imidazole pK1 of histidine-57 is greater than or equal to 8.1.	Histidine	55-64	prokineticin 1	Homo sapiens	48-51
12766158-5	2003	Because it had been proposed that a histidine residue might be the proximal heme ligand in IDO, mutation to alanine of the three highly conserved histidines His16, His303, and His346 was conducted.	Histidine	36-45	indoleamine 2,3-dioxygenase 1	Homo sapiens	91-94
12766158-5	2003	Because it had been proposed that a histidine residue might be the proximal heme ligand in IDO, mutation to alanine of the three highly conserved histidines His16, His303, and His346 was conducted.	Histidine	146-156	indoleamine 2,3-dioxygenase 1	Homo sapiens	91-94
30187685-1	2018	HLA-B*40:06:07 has one synonymous nucleotide change from HLA-B*40:06:01:01 at nucleotide 81 (codon 3 histidine).	Histidine	101-110	major histocompatibility complex, class I, B	Homo sapiens	57-62
3926517-2	1985	injection of histidyl-proline diketopiperazine [cyclo (His-Pro)], an active metabolite of thyrotropin-releasing hormone (TRH) in mice produced an antinociceptive effect in a dose-dependent manner as measured in four antinociceptive tests; tail-pressure, tail-flick, hot-plate and acetic acid writhing.	Histidine	55-58	thyrotropin releasing hormone	Mus musculus	90-119
29148316-0	2018	Recognition dynamics of trinuclear copper cluster and associated histidine residues through conserved or semi-conserved water molecules in human Ceruloplasmin: The involvement of aspartic and glutamic acid gates.	Histidine	65-74	ceruloplasmin	Homo sapiens	145-158
3926517-2	1985	injection of histidyl-proline diketopiperazine [cyclo (His-Pro)], an active metabolite of thyrotropin-releasing hormone (TRH) in mice produced an antinociceptive effect in a dose-dependent manner as measured in four antinociceptive tests; tail-pressure, tail-flick, hot-plate and acetic acid writhing.	Histidine	55-58	thyrotropin releasing hormone	Mus musculus	121-124
12815280-5	2003	To test this hypothesis, the peptide zAsp(Ome)-Arg-His-Asp(Ome)-fluoromethyl ketone (zDRHDfmk) was synthesized.	Histidine	51-54	LIM domain binding 3a	Danio rerio	37-41
12815280-5	2003	To test this hypothesis, the peptide zAsp(Ome)-Arg-His-Asp(Ome)-fluoromethyl ketone (zDRHDfmk) was synthesized.	Histidine	51-54	LIM domain binding 3a	Danio rerio	38-41
30449824-1	2018	L-type amino acid transporter 1 (LAT1) functions to transport large neutral amino acids, such as leucine, isoleucine, valine, phenylalanine, tyrosine, tryptophan, methionine, and histidine.	Histidine	179-188	solute carrier family 7 member 5	Homo sapiens	0-31
3986189-8	1985	As with the parent HRG molecule, interaction of the peptide with heme and metals is dependent on pH and intact histidine residues.	Histidine	111-120	histidine rich glycoprotein	Homo sapiens	19-22
30449824-1	2018	L-type amino acid transporter 1 (LAT1) functions to transport large neutral amino acids, such as leucine, isoleucine, valine, phenylalanine, tyrosine, tryptophan, methionine, and histidine.	Histidine	179-188	solute carrier family 7 member 5	Homo sapiens	33-37
3841693-4	1985	The data support the following prerequisites for the maximal neuromodulatory role of bombesin-like peptides on gastric secretion: Trp is required at position 8; Gln and His are important at positions 7 and 12, respectively; Leu replacement by Phe, which occurs in the litorin subfamily, modifies the response; and unspecified amino acids or sequences are also involved in the N-terminal region of bombesin-like peptides.	Histidine	169-172	gastrin releasing peptide	Homo sapiens	85-93
12740384-1	2003	Histidines 107 and 109 in the glycine receptor (GlyR) alpha1 subunit have previously been identified as determinants of the inhibitory zinc-binding site.	Histidine	0-10	glycine receptor alpha 1	Homo sapiens	30-60
29902001-6	2018	The chemical modification of alpha-glucosidase verified the results of the computer simulation that the order of importance of the four amino acid residues in the binding process was His &gt; Tyr &gt; Lys &gt; Arg.	Histidine	183-186	sucrase-isomaltase	Homo sapiens	29-46
12748294-1	2003	The histidine triad (HIT) protein Hint has been found to associate with mammalian Cdk7, as well as to interact both physically and genetically with the budding yeast Cdk7 homologue Kin28.	Histidine	4-13	cyclin-dependent kinase 7	Mus musculus	166-170
12748294-1	2003	The histidine triad (HIT) protein Hint has been found to associate with mammalian Cdk7, as well as to interact both physically and genetically with the budding yeast Cdk7 homologue Kin28.	Histidine	4-13	TFIIH complex serine/threonine-protein kinase subunit KIN28	Saccharomyces cerevisiae S288C	181-186
3920737-5	1985	Cyclo(His-Pro) concentrations in the whole brain were significantly greater in the LPD group than in the pair-fed and ad libitum groups, whereas its concentrations were similar in the pair-fed and ad libitum groups.	Histidine	6-9	acyl-CoA synthetase bubblegum family member 1	Rattus norvegicus	83-86
29635803-11	2018	In contrast, HI decreased AMPK activation in both cell lines, whereas it increased ERK1/2 levels in PNT1A and decreased them in PC3 (reflecting greater cell proliferation only in non-tumor cells).	Histidine	13-15	chromobox 8	Homo sapiens	128-131
6431907-0	1984	A carbon-13 NMR comparative study of metal ion substitutions in human carbonic anhydrase I carboxymethylated at active-site histidine-200.	Histidine	124-133	carbonic anhydrase 1	Homo sapiens	70-90
12771201-0	2003	The phage T4 restriction endoribonuclease RegB: a cyclizing enzyme that requires two histidines to be fully active.	Histidine	85-95	site-specific RNA endonuclease	Escherichia phage T4	42-46
12771201-5	2003	In order to determine the residues crucial for its activity, we prepared all the histidine-to- alanine point mutants of RegB.	Histidine	81-90	site-specific RNA endonuclease	Escherichia phage T4	120-124
29718430-14	2018	Plasma Ile, Leu, and Val were lower, and plasma His was greater in +LPS than -LPS steers (LPS, P &lt; 0.05).	Histidine	48-51	interferon regulatory factor 6	Homo sapiens	78-81
12856592-4	2003	Western blot analysis with specific anti-histidines antibody revealed that the lysate of COS-7 cells transfected by rpcDNA3.1/Myc-His/hBD-2 had a strong band with molecular weight of about 10 Kd that was approximate to the size of chiasmic peptide.	Histidine	41-51	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	126-129
6432037-0	1984	Paramagnetic 1H and 13C NMR studies on cobalt-substituted human carbonic anhydrase I carboxymethylated at active site histidine-200: molecular basis for the changes in catalytic properties induced by the modification.	Histidine	118-127	carbonic anhydrase 1	Homo sapiens	64-84
6086335-12	1984	Since this section contains the catalytic residues such as His-36 and Asp-93, we conclude that AK1 can serve as a three-dimensional model of AK2 in mechanistic and drug-designing studies.	Histidine	59-62	adenylate kinase 1	Bos taurus	95-98
6725279-9	1984	beta-Thrombin was observed to undergo modification at the active site histidine at a slower rate than that of alpha-thrombin when reacted with either tosyllysyl chloromethyl ketone or diethyl pyrocarbonate.	Histidine	70-79	coagulation factor II, thrombin	Bos taurus	5-13
6725279-10	1984	It is suggested that the difference in the fibrinogen-clotting activity of these two forms of thrombin can result from changes in the reactivity of the active site histidine residue.	Histidine	164-173	coagulation factor II, thrombin	Bos taurus	94-102
12837208-4	2003	Yeast cells co-transfected with pAS2-1-PreS1 and the normal human liver cDNA library grew in selective SC/-trp-leu-his-ade2 medium, and the second screening was performed with LacZ report gene.	Histidine	115-118	E2 ubiquitin-protein ligase peroxin 4	Saccharomyces cerevisiae S288C	32-36
29718430-14	2018	Plasma Ile, Leu, and Val were lower, and plasma His was greater in +LPS than -LPS steers (LPS, P &lt; 0.05).	Histidine	48-51	interferon regulatory factor 6	Homo sapiens	78-81
29813003-8	2018	Western blot showed that the His-TRIM62 and endogenous TRIM62 were recognized by the mAb.	Histidine	29-32	tripartite motif containing 62	Gallus gallus	33-39
12570875-3	2003	Binding was restored following urea denaturation, suggesting that Lck/V5-His is in a "closed" conformation in these domains.	Histidine	73-76	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	66-69
12570875-9	2003	Co-immunoprecipitation experiments from Tyr(505) --&gt; Phe/V5-His-expressing cells revealed that LAT preferentially interacts with the "open" form of Lck in T cell raft domains.	Histidine	63-66	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	151-154
6689270-12	1983	Redox titration of the modified reductase with NADPH and with reduced ferredoxin suggested that the second histidine might be located in the electron pathway between FAD and ferredoxin.	Histidine	107-116	2,4-dienoyl-CoA reductase 1	Homo sapiens	47-52
6194822-2	1983	Residues 67 to 75 in myelin basic protein from several species comprise the sequence Thr-His-Tyr-Gly-Ser-Leu-Pro-Gln-Lys that acts as an encephalitogenic determinant in the rabbit.	Histidine	89-92	myelin basic protein	Oryctolagus cuniculus	21-41
29622686-9	2018	VIPP1-His showed GTP hydrolysis activity that was inhibited competitively by an unhydrolyzable GTP analog, GTPgammaS, and that depends on GTP binding.	Histidine	6-9	plastid transcriptionally active 4	Arabidopsis thaliana	0-5
12738633-5	2003	The recombinant proteins MOMP and Hsp60 were purified from the bacterial lysate with the aid of the carboxy-terminal histidine hexamer tag by affinity chromatography.	Histidine	117-126	heat shock protein 1 (chaperonin)	Mus musculus	34-39
12684778-2	2003	Spot-1 interacts with the nuclear localization signal (NLS) I of p53 through its His-Thr domain.	Histidine	81-84	transformation related protein 53, pseudogene	Mus musculus	65-68
6574481-4	1983	In the presence of Leu-tRNA or His-tRNA, the tripeptides fMet-Val-Leu and fMet-Val-His are synthesized, corresponding to the NH2-terminal sequence of alpha- and beta-globin, respectively.	Histidine	31-34	hemoglobin subunit beta-1/2	Oryctolagus cuniculus	150-172
29594302-2	2018	Ir1 with a two-photon action cross-section of 40 GM in the NIR region has been developed for targeting intracellular histidine.	Histidine	117-126	nischarin	Homo sapiens	0-3
6574481-4	1983	In the presence of Leu-tRNA or His-tRNA, the tripeptides fMet-Val-Leu and fMet-Val-His are synthesized, corresponding to the NH2-terminal sequence of alpha- and beta-globin, respectively.	Histidine	83-86	hemoglobin subunit beta-1/2	Oryctolagus cuniculus	150-172
12926399-3	2003	Barrels with internal arginine-histidine dyads form cation selective (PK/Pc1 = 2.1), small and ohmic ion channels with superb stability (single-channel lifetime &gt; 20 seconds).	Histidine	31-40	polycystin 1, transient receptor potential channel interacting	Homo sapiens	73-76
12650998-0	2003	Mutation of surface-exposed histidine residues of recombinant human granulocyte-colony stimulating factor (Cys17Ser) impacts on interaction with chelated metal ions and refolding in aqueous two-phase systems.	Histidine	28-37	colony stimulating factor 3	Homo sapiens	68-105
6280031-7	1982	The interaction of the charge of this His with the negatively charged group of Cyt c is necessary, probably for the proper arrangement of other interactions in the active complex, because the deprotonation of His-GHl in the studied pH interval decreases the rate of the process by more than one order of magnitude.	Histidine	38-41	growth hormone 2	Homo sapiens	213-216
29594302-3	2018	Two-photon micrographs showed that Ir1 could rapidly and selectively light up the nucleus in both fixed and live cells and is capable of displaying nuclear histidine distribution in ultra-detail using a super resolution (SR) technique under stimulated emission depletion (STED) microscopy.	Histidine	156-165	nischarin	Homo sapiens	35-38
6280031-7	1982	The interaction of the charge of this His with the negatively charged group of Cyt c is necessary, probably for the proper arrangement of other interactions in the active complex, because the deprotonation of His-GHl in the studied pH interval decreases the rate of the process by more than one order of magnitude.	Histidine	209-212	growth hormone 2	Homo sapiens	213-216
29463897-0	2018	Molecular basis for histidine N1 position-specific methylation by CARNMT1.	Histidine	20-29	carnosine N-methyltransferase 1	Homo sapiens	66-73
7260037-0	1981	Resonance Raman and absorption spectroscopic detection of distal histidine--fluoride interactions in human methemoglobin fluoride and sperm whale metmyoglobin fluoride: measurements of distal histidine ionization constants.	Histidine	65-74	hemoglobin subunit gamma 2	Homo sapiens	107-120
12616630-5	2003	The NMR structure of the SUPERMAN zinc finger domain consists of a very well-defined betabetaalpha motif, typical of all other Cys(2)-His(2) zinc fingers structurally characterized.	Histidine	134-137	C2H2 and C2HC zinc fingers superfamily protein	Arabidopsis thaliana	25-33
29362492-2	2018	Diphthamide is the posttranslationally modified histidine residue on EEF2 that promotes protein chain elongation in the ribosome.	Histidine	48-57	eukaryotic translation elongation factor 2	Homo sapiens	69-73
12594264-4	2003	We investigated the potential of recombinant, His-tagged p19 lacking the secretion/acylation signal to induce macrophage apoptosis.	Histidine	46-49	interleukin 23 subunit alpha	Homo sapiens	57-60
6260763-9	1981	The pKa for His-91 was shifted to the alkaline side in the presence of 3"-GMP, a competitive inhibitor, in the titration plots observed by both hydrogen-tritium exchange and 1H NMR spectroscopy.	Histidine	12-15	5'-nucleotidase, cytosolic II	Homo sapiens	74-77
6260763-10	1981	The 31P NMR titration data suggest that in the 3"-GMP-RNase St complex the dianion form of the nucleotide participates in the interaction with the protonated form of His-91.	Histidine	166-169	5'-nucleotidase, cytosolic II	Homo sapiens	50-53
28911864-3	2018	The key activation event involves the rearrangement of the HAMP-DHp helical core and translation of the CA towards the acceptor histidine, which presumably results in an autokinase-competent complex.	Histidine	128-137	hepcidin antimicrobial peptide	Homo sapiens	59-63
6900508-0	1980	Proton nuclear magnetic resonance study on the roles of histidine residues in the binding of polypeptide chain elongation factor Tu from Thermus thermophilus with aminoacyl transfer ribonucleic acid and guanine nucleotides.	Histidine	56-65	elongation factor Tu	Thermus thermophilus HB8	111-131
6900508-7	1980	A hydrogen-deuterium exchange experiment was carried out on the histidine C2 protons of free EF-Tu, and the previous assignments of C2 proton signals were revised in part.	Histidine	64-73	elongation factor Tu	Thermus thermophilus HB8	93-98
6900508-8	1980	An analysis of the 1H NMR spectra of EF-Tu photooxidized under various conditions indicates that a histidine residue is located in the aminoacyl-tRNA binding site and is probably essential for the binding with aminoacyl-tRNA.	Histidine	99-108	elongation factor Tu	Thermus thermophilus HB8	37-42
6900508-10	1980	Furthermore, the effect of paramagnetic hexacyanochromate(III) ion on the 1H NMR spectra of free EF-Tu suggests that another histidine residue lies near the guanine nucleotide binding site.	Histidine	125-134	elongation factor Tu	Thermus thermophilus HB8	97-102
7356971-7	1980	The pH profile suggests the participation of a protonated enzyme group(s) (pK = 7.2-7.5) in NADPH binding, probably a histidine residue.	Histidine	118-127	2,4-dienoyl-CoA reductase 1	Homo sapiens	92-97
12536071-6	2003	Additional mammalian proteins of interest to signal transduction and cancer research exhibit histidine phosphorylation, including P-selectin, annexin I and the 20S proteasome.	Histidine	93-102	selectin P	Homo sapiens	130-140
12669234-8	2003	The poly-clonal antibody raised against histidine-tagged fusion PTEN protein showed specific immuno-reactivity to PTEN protein.	Histidine	40-49	phosphatase and tensin homolog	Homo sapiens	64-68
12669234-8	2003	The poly-clonal antibody raised against histidine-tagged fusion PTEN protein showed specific immuno-reactivity to PTEN protein.	Histidine	40-49	phosphatase and tensin homolog	Homo sapiens	114-118
29470101-4	2018	To investigate whether Ebselen could be an inhibitor for human GDH, we cloned and expressed an N-terminal His-tagged human GDH in E. coli.	Histidine	106-109	glutamate dehydrogenase 1	Homo sapiens	123-126
7352984-5	1980	A model study of the azide-methemoglobin complex suggested that the increase of the high-spin character of the beta heme iron is due to a conformational change of the proximal histidine which weakens the interaction between the heme iron and the proximal base.	Histidine	176-185	hemoglobin subunit gamma 2	Homo sapiens	27-40
476954-1	1979	A new sensitive method was developed for assay of histidase in the stratum corneum of human skin with [14C] histidine as substrate.	Histidine	108-117	histidine ammonia-lyase	Homo sapiens	50-59
28965571-3	2017	The protein sequence analysis of hTLR4 revealed that the ectodomain, the region supposed to coordinate the metal ions, contains a histidine-rich motif that is not conserved among all organisms.	Histidine	130-139	toll like receptor 4	Homo sapiens	33-38
31898-1	1978	Proton magnetic resonance pH titration studies of the two histidines of bovine chymotrypsinogen A and chymotrypsin Aalpha.	Histidine	58-68	chymotrypsinogen A	Bos taurus	79-121
12605682-8	2003	The existence of activity when the catalytic histidine is protonated indicates that the catalytic-triad mechanism of butyrylcholinesterase does not operate for catalysis at low pH.	Histidine	45-54	butyrylcholinesterase	Homo sapiens	117-138
12459164-1	2002	Feline granulocyte colony-stimulating factor (G-CSF) with an N-terminal histidine hexamer tag was expressed as inclusion bodies in E. coli.	Histidine	72-81	colony stimulating factor 3	Felis catus	46-51
29445441-7	2017	There was a deoxyribonucleic acid variant with transversion of alanine with tyrosine and change of histidine with leucine on notch 3 gene.	Histidine	99-108	notch receptor 3	Homo sapiens	125-132
656435-0	1978	An essential active-site histidine residue in human prostatic acid phosphatase.	Histidine	25-34	acid phosphatase 3	Homo sapiens	52-78
23288-0	1977	Nuclear-magnetic-resonance study of the histidine residues of S-peptide and S-protein and kinetics of 1H-2H exchange of ribonuclease A.	Histidine	40-49	vitronectin	Homo sapiens	76-85
23288-10	1977	The reassignment of the three C-2 histidine resonances of S-protein is confirmed by partial deuteration studies.	Histidine	34-43	vitronectin	Homo sapiens	58-67
12361957-9	2002	Such activation was eliminated when a histidine residue in the M1-H5 linker was mutated to a non-titratable glutamine, i.e. H116Q in GIRK1 and H120Q in GIRK4.	Histidine	38-47	potassium inwardly rectifying channel subfamily J member 5 L homeolog	Xenopus laevis	152-157
23288-12	1977	The S-protein is less stable to acid than RNase-A since the former, but not the latter, shows evidence of reversible denaturation at pH 3 and 26 degrees C. His-48 in S-protein titrates normally and has a lower pK than in RN-ase-A probably because of the absence of Asp-14, which in RN-ase-A forms a a hydrogen bond with His-48 and causes it to be inaccessible to solvent, at pH values below 9.	Histidine	156-159	vitronectin	Homo sapiens	4-13
28942838-2	2017	In addition to its fundamental role in nucleotide metabolism, Ndk has roles in protein histidine phosphorylation, DNA cleavage/repair, and gene regulation.	Histidine	87-96	cytidine/uridine monophosphate kinase 2	Homo sapiens	62-65
23288-12	1977	The S-protein is less stable to acid than RNase-A since the former, but not the latter, shows evidence of reversible denaturation at pH 3 and 26 degrees C. His-48 in S-protein titrates normally and has a lower pK than in RN-ase-A probably because of the absence of Asp-14, which in RN-ase-A forms a a hydrogen bond with His-48 and causes it to be inaccessible to solvent, at pH values below 9.	Histidine	156-159	vitronectin	Homo sapiens	166-175
23288-12	1977	The S-protein is less stable to acid than RNase-A since the former, but not the latter, shows evidence of reversible denaturation at pH 3 and 26 degrees C. His-48 in S-protein titrates normally and has a lower pK than in RN-ase-A probably because of the absence of Asp-14, which in RN-ase-A forms a a hydrogen bond with His-48 and causes it to be inaccessible to solvent, at pH values below 9.	Histidine	320-323	vitronectin	Homo sapiens	4-13
23288-12	1977	The S-protein is less stable to acid than RNase-A since the former, but not the latter, shows evidence of reversible denaturation at pH 3 and 26 degrees C. His-48 in S-protein titrates normally and has a lower pK than in RN-ase-A probably because of the absence of Asp-14, which in RN-ase-A forms a a hydrogen bond with His-48 and causes it to be inaccessible to solvent, at pH values below 9.	Histidine	320-323	vitronectin	Homo sapiens	166-175
893419-2	1977	TnC was found to be a single polypeptide chain of 159 amino acid residues, including 2 residues of tyrosine and 1 each of cysteine, histidine, and proline.	Histidine	132-141	tenascin	Oryctolagus cuniculus	0-3
12202490-4	2002	The active site histidines, His-15 of HPr and His-65 of IIA(Mtl), are in close spatial proximity, and a pentacoordinate phosphoryl transition state can be readily accommodated with no change in protein-protein orientation and only minimal perturbations of the backbone immediately adjacent to the histidines.	Histidine	16-26	colicin Ia immunity protein	Escherichia coli	56-59
12202490-4	2002	The active site histidines, His-15 of HPr and His-65 of IIA(Mtl), are in close spatial proximity, and a pentacoordinate phosphoryl transition state can be readily accommodated with no change in protein-protein orientation and only minimal perturbations of the backbone immediately adjacent to the histidines.	Histidine	28-31	colicin Ia immunity protein	Escherichia coli	56-59
12202490-4	2002	The active site histidines, His-15 of HPr and His-65 of IIA(Mtl), are in close spatial proximity, and a pentacoordinate phosphoryl transition state can be readily accommodated with no change in protein-protein orientation and only minimal perturbations of the backbone immediately adjacent to the histidines.	Histidine	46-49	colicin Ia immunity protein	Escherichia coli	56-59
12202490-4	2002	The active site histidines, His-15 of HPr and His-65 of IIA(Mtl), are in close spatial proximity, and a pentacoordinate phosphoryl transition state can be readily accommodated with no change in protein-protein orientation and only minimal perturbations of the backbone immediately adjacent to the histidines.	Histidine	297-307	colicin Ia immunity protein	Escherichia coli	56-59
29162828-7	2017	Epitope mapping reveals that AE2 recognizes a region of human SeP adjacent to the first histidine-rich region (FHR).	Histidine	88-97	solute carrier family 4 member 2	Homo sapiens	29-32
870089-4	1977	However, the rat muscle glyceraldehyde-3-phosphate dehydrogenase is characterised by a markedly lower histidine content.	Histidine	102-111	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	24-64
29226085-0	2017	Cysteine and histidine residues are involved in Escherichia coli Tn21 MerE methylmercury transport.	Histidine	13-22	MerE	Escherichia coli	70-74
14120-10	1976	3"-GMP and guanosine showed some protective effect against loss of activity and of histidine residues.	Histidine	83-92	5'-nucleotidase, cytosolic II	Homo sapiens	3-6
14120-15	1976	On the other hand, alkylation of histidine-40 was slowed down most in the presence of 3"-GMP.	Histidine	33-42	5'-nucleotidase, cytosolic II	Homo sapiens	89-92
12105206-7	2002	Site-directed mutagenesis of the EGFR L2 domain showed that a cluster of residues, His(394)-Ile(402), was essential for both decorin and EGF binding.	Histidine	83-86	decorin	Homo sapiens	125-132
12234472-0	2002	Detection of polymorphisms at exons 3 (Tyr113--&gt;His) and 4 (His139--&gt;Arg) of the microsomal epoxide hydrolase gene using fluorescence PCR method combined with melting curves analysis.	Histidine	51-54	epoxide hydrolase 1	Homo sapiens	87-115
28709952-4	2017	Inhibition was tested on the antiport catalysed by hLAT1 as transport of extraliposomal [3H]histidine in exchange with intraliposomal histidine.	Histidine	92-101	solute carrier family 7 member 5	Homo sapiens	51-56
12042318-5	2002	We compared biochemical and functional features of wild type flavocytochrome b558 with those in cells co-expressing gp91(phox) with p22(phox) harboring amino acid substitutions at histidine 94, the only invariant histidine residue within the p22(phox) subunit.	Histidine	180-189	calcineurin like EF-hand protein 1	Homo sapiens	132-135
976263-3	1976	The alkylation of a histidine residue which is fast and extensive when the alkylation side chain is on the C-3 carbon atom, is dramatically decreased when alkylating side chain is shifted towards rings B and D. These results allow the location of this histidine in the vicinity of ring A and probably on the beta face of the steroid nucleus.	Histidine	20-29	complement C3	Homo sapiens	107-110
976263-3	1976	The alkylation of a histidine residue which is fast and extensive when the alkylation side chain is on the C-3 carbon atom, is dramatically decreased when alkylating side chain is shifted towards rings B and D. These results allow the location of this histidine in the vicinity of ring A and probably on the beta face of the steroid nucleus.	Histidine	252-261	complement C3	Homo sapiens	107-110
4454-2	1976	One of the four titrating histidine ring C-2 proton resonances of bovine pancreatic ribonuclease has been assigned to histidine residue 12.	Histidine	26-35	complement C2	Bos taurus	41-44
4454-2	1976	One of the four titrating histidine ring C-2 proton resonances of bovine pancreatic ribonuclease has been assigned to histidine residue 12.	Histidine	118-127	complement C2	Bos taurus	41-44
4454-3	1976	This was accomplished by a direct comparison of the rate of tritium incorporation into position C-2 of histidine 12 of S-peptide (residues 1 to 20) derived from ribonuclease S, with the rates of deuterium exchange of the four histidine C-2 proton resonances of ribonuclease S under the same experimental conditions.	Histidine	103-112	complement C2	Bos taurus	96-99
4455-3	1976	Although S-protein contains 3 histidine residues, four discrete resonances are observed to titrate.	Histidine	30-39	vitronectin	Homo sapiens	9-18
28709952-4	2017	Inhibition was tested on the antiport catalysed by hLAT1 as transport of extraliposomal [3H]histidine in exchange with intraliposomal histidine.	Histidine	134-143	solute carrier family 7 member 5	Homo sapiens	51-56
4455-4	1976	One of these arises from the equivalent histidine residues of unfolded S-protein.	Histidine	40-49	vitronectin	Homo sapiens	71-80
4455-6	1976	Two of the resonances of the folded S-protein can be assigned to 2 of the histidine residues, 48 and 105, from the close similarity of their titration curves to those in ribonuclease.	Histidine	74-83	vitronectin	Homo sapiens	36-45
28532685-3	2017	The purpose of this paper is to address the inhibition of protein disulfide isomerase (PDI), an essential redox chaperone whose active sites contain the Cys-Gly-His-Cys (CXXC) motif, by the nitroxide Tempol.	Histidine	161-164	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	58-85
4455-9	1976	The low pH inflection present in the titration curve assigned to histidine residue 48 in ribonuclease is absent from this curve in S-protein.	Histidine	65-74	vitronectin	Homo sapiens	131-140
4455-11	1976	The third titrating resonance of native S-protein is assigned to the remaining histidine residue at position 119.	Histidine	79-88	vitronectin	Homo sapiens	40-49
4455-13	1976	The resonance assigned to histidine 119 is the only one significantly affected on the addition of sodium phosphate to S-protein, indicating that some degree of phosphate binding occurs.	Histidine	26-35	vitronectin	Homo sapiens	118-127
238843-8	1975	In the presence of phosphate, titration curves for the H-2 proton resonances of histidine-12 and histidine-119 of methylated RNase-A indicate binding of phosphate at the active site, but these curves continue to show deviations from the titration behaviour of native RNase-A.	Histidine	97-106	relaxin 2	Homo sapiens	55-58
234739-3	1975	The seven resonances observed in the histidine region of the proton magnetic resonance (pmr) spectrum of human carbonic anhydrase B and reported in the preceding paper are studied in the presence of sulfonamide, azide, cyanide, and chloride inhibitors and in metal-free, cadmium substituted, cobalt substituted, and carboxymethylated forms of the enzyme.	Histidine	37-46	carbonic anhydrase 2	Homo sapiens	111-131
234740-3	1975	Resonances of the histidine region of human carbonic anhydrase B have been studied by proton magnetic resonance spectroscopy in the presence of seven sulfonamide inhibitors.	Histidine	18-27	carbonic anhydrase 2	Homo sapiens	44-64
12052343-6	2002	By addition of histidine hexamer at the C-terminal of boIL-18, the mature IL-18 was purified.	Histidine	15-24	interleukin 18	Bos taurus	56-61
12106978-8	2002	Moreover, several histidine-inserted or -deleted hEGF mutants were prebound to rat liver sinusoidal membrane vesicle, followed by further incubation at 37 degrees C. The dissociation rate of histidine-deleted hEGF mutants was less rapid than that of hEGF itself.	Histidine	191-200	epidermal growth factor	Homo sapiens	49-53
12106978-8	2002	Moreover, several histidine-inserted or -deleted hEGF mutants were prebound to rat liver sinusoidal membrane vesicle, followed by further incubation at 37 degrees C. The dissociation rate of histidine-deleted hEGF mutants was less rapid than that of hEGF itself.	Histidine	191-200	epidermal growth factor	Homo sapiens	209-213
12106978-8	2002	Moreover, several histidine-inserted or -deleted hEGF mutants were prebound to rat liver sinusoidal membrane vesicle, followed by further incubation at 37 degrees C. The dissociation rate of histidine-deleted hEGF mutants was less rapid than that of hEGF itself.	Histidine	191-200	epidermal growth factor	Homo sapiens	209-213
28532685-3	2017	The purpose of this paper is to address the inhibition of protein disulfide isomerase (PDI), an essential redox chaperone whose active sites contain the Cys-Gly-His-Cys (CXXC) motif, by the nitroxide Tempol.	Histidine	161-164	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	87-90
28644885-10	2017	In addition, we also detected OATP1B3-FLAG co-localization with OATP1B1-His or NTCP-His, suggesting that OATP1B3 also hetero-oligomerizes with other transport proteins.	Histidine	72-75	solute carrier organic anion transporter family member 1B1	Homo sapiens	64-71
12061882-7	2002	These studies provide further experimental evidence that the His(6) position can determine MC4R versus MC3R agonist selectivity and that chemically nonreactive side chains may be substituted for the imidazole ring (generally needs to be side chain protected in synthetic schemes) in the design of MC4R-selective, small-molecule, non-peptide agonists.	Histidine	61-64	melanocortin 4 receptor	Mus musculus	91-95
788422-0	1975	[Histidine tolerance in low skin histidase activity].	Histidine	1-10	histidine ammonia-lyase	Homo sapiens	33-42
28302724-6	2017	These results, together with the previous results for the mutants of the His ligands of PD1 and PD2, lead to a definite conclusion that a charge is mainly localized to PD1 in P680&lt;sup/&gt;.	Histidine	73-76	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	96-99
4217387-0	1974	A study of the histidine residues of human carbonic anhydrase B using 270 MHz proton magnetic resonance.	Histidine	15-24	carbonic anhydrase 2	Homo sapiens	43-63
28349924-5	2017	To understand how this gelsolin fragment is activated for F-actin severing by lowering pH, we solved its NMR structures at both pH 7.3 and 5 in the absence of Ca2+ and measured the pKa values of acidic amino acid residues and histidine residues.	Histidine	226-235	gelsolin	Homo sapiens	23-31
26764162-5	2017	The intracellular detection of PPi using PCG also carried out in B16F10 cells where &gt;10 times observed as compared to the PDI-HIS+Cu2+ complex.	Histidine	129-132	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	125-128
4928005-6	1971	(iv) The pathway by which exogenous adenine is converted to guanine nucleotides in the presence of histidine requires a functional purine nucleoside phosphorylase.	Histidine	99-108	purine-nucleoside phosphorylase	Salmonella enterica subsp. enterica serovar Typhimurium str. LT2	131-162
12054669-5	2002	Hsc56 contains the -His-Pro-Glu- sequence corresponding to the His-Pro-Asp motif in DnaJ, which is indispensable for DnaJ to interact with DnaK.	Histidine	20-23	DnaJ	Escherichia coli	84-88
28088787-1	2017	Histidine triad nucleotide-binding 2 (HINT2), a member of the histidine triad proteins family, sensitizes cells to apoptosis in hepatocellular carcinoma.	Histidine	62-71	histidine triad nucleotide binding protein 2	Homo sapiens	0-36
12054669-5	2002	Hsc56 contains the -His-Pro-Glu- sequence corresponding to the His-Pro-Asp motif in DnaJ, which is indispensable for DnaJ to interact with DnaK.	Histidine	20-23	DnaJ	Escherichia coli	117-121
12054669-5	2002	Hsc56 contains the -His-Pro-Glu- sequence corresponding to the His-Pro-Asp motif in DnaJ, which is indispensable for DnaJ to interact with DnaK.	Histidine	63-66	DnaJ	Escherichia coli	84-88
12054669-5	2002	Hsc56 contains the -His-Pro-Glu- sequence corresponding to the His-Pro-Asp motif in DnaJ, which is indispensable for DnaJ to interact with DnaK.	Histidine	63-66	DnaJ	Escherichia coli	117-121
13863215-1	1962	A deficiency in histidase resulting in the urinary excretion of histidine and of imidazolepyruvic acid.	Histidine	64-73	histidine ammonia-lyase	Homo sapiens	16-25
28088787-1	2017	Histidine triad nucleotide-binding 2 (HINT2), a member of the histidine triad proteins family, sensitizes cells to apoptosis in hepatocellular carcinoma.	Histidine	62-71	histidine triad nucleotide binding protein 2	Homo sapiens	38-43
11916859-7	2002	Because cx46 and cx50 have very similar amino acid sequences, one might expect that replacing the two histidines unique to the third transmembrane region of cx50 with the corresponding cx46 residues would produce mutants more closely resembling cx46.	Histidine	102-112	gap junction protein alpha 3	Homo sapiens	8-12
27940575-3	2017	Either ectopic expression of mda-7/IL-24 or treatment with recombinant His-MDA-7 protein resulted in downregulation of miR-221 and upregulation of p27 and PUMA in a panel of cancer cells, culminating in cell death.	Histidine	71-74	interleukin 24	Homo sapiens	75-80
11916859-7	2002	Because cx46 and cx50 have very similar amino acid sequences, one might expect that replacing the two histidines unique to the third transmembrane region of cx50 with the corresponding cx46 residues would produce mutants more closely resembling cx46.	Histidine	102-112	gap junction protein alpha 3	Homo sapiens	185-189
11916859-7	2002	Because cx46 and cx50 have very similar amino acid sequences, one might expect that replacing the two histidines unique to the third transmembrane region of cx50 with the corresponding cx46 residues would produce mutants more closely resembling cx46.	Histidine	102-112	gap junction protein alpha 3	Homo sapiens	185-189
33686575-7	2021	In particular primitive fish TTR has an extremely high zinc content, with an increased number of histidine residues which are involved in TH binding.	Histidine	97-106	transthyretin	Homo sapiens	29-32
34046594-2	2021	Histidine methylation has recently attracted attention through the discovery of the human histidine methyltransferase enzymes SETD3 and METTL9.	Histidine	0-9	methyltransferase like 9	Homo sapiens	136-142
34046594-2	2021	Histidine methylation has recently attracted attention through the discovery of the human histidine methyltransferase enzymes SETD3 and METTL9.	Histidine	90-99	methyltransferase like 9	Homo sapiens	136-142
11991203-1	2002	CD spectra of a tandem 27-mer repeat polypeptide, Gln-Pro-His-Gln-Pro-Leu-Gln-Pro-His-Gln-Pro-Leu-Gln-Pro-Met-(Gln-Pro-Leu)4, from bovine amelogenin synthesized by standard solid-phase synthesis manifests an archtypical CD pattern of a beta-spiral structure in phosphate buffer at pH 5.2 and trifluoroethanol (TFE), CF3OH.	Histidine	58-61	amelogenin, X isoform	Bos taurus	138-148
34036185-4	2021	We demonstrate that the presence of the six-polyhistidine tag at the amino terminus of the proteins led to a decrease in their oxidoreductase enzymatic activity compared to their non-His-tagged counterparts, when assessed using 2-hydroxyethyl disulfide as a substrate.	Histidine	183-186	thioredoxin reductase 1	Homo sapiens	127-141
27940575-3	2017	Either ectopic expression of mda-7/IL-24 or treatment with recombinant His-MDA-7 protein resulted in downregulation of miR-221 and upregulation of p27 and PUMA in a panel of cancer cells, culminating in cell death.	Histidine	71-74	microRNA 221	Homo sapiens	119-126
33942499-0	2021	Self-Assembly or Coassembly of Multiresponsive Histidine-Containing Elastin-Like Polypeptide Block Copolymers.	Histidine	47-56	elastin	Homo sapiens	68-75
28261230-4	2017	The three TaRAR1 proteins all contain two conserved cysteine-and histidine-rich domains (CHORD-I and -II) shared by known RAR1-like proteins.	Histidine	65-74	zinc-binding protein	Hordeum vulgare	12-16
33682303-2	2021	The product of THG1L is the tRNA-histidine guanylyltransferase 1-like enzyme that catalyzes the 3"-5"addition of guanine to the 5"-end of tRNA-histidine in the mitochondrion.	Histidine	33-42	tRNA-histidine guanylyltransferase 1 like	Homo sapiens	15-20
33682303-2	2021	The product of THG1L is the tRNA-histidine guanylyltransferase 1-like enzyme that catalyzes the 3"-5"addition of guanine to the 5"-end of tRNA-histidine in the mitochondrion.	Histidine	143-152	tRNA-histidine guanylyltransferase 1 like	Homo sapiens	15-20
11844751-8	2002	Exchange of this His residue for Asn led to inactivation of MrsD.	Histidine	17-20	MRSD	Homo sapiens	60-64
28289488-2	2017	Although histidine at position 50 in the aSyn sequence is one of the most studied copper-anchoring sites, its precise role in copper binding and aSyn aggregation is still unclear.	Histidine	9-18	synuclein alpha	Homo sapiens	41-45
11723122-4	2002	The relative molar expression of these subtypes was quantified through comparison with histidine-tagged UCP1 or UCP2 proteins engineered by expression in Escherichia coli.	Histidine	87-96	uncoupling protein 1	Homo sapiens	104-108
11903230-5	2002	RESULTS: We identified a heterozygous arginine to histidine p63 mutation, R279H, in all three affected individuals.	Histidine	50-59	tumor protein p63	Homo sapiens	60-63
33555507-8	2021	The results from Hi-MethylSeq showed that the hypermethylation of SGK1 in both blood and decidua samples in RPL patients, which was consistent to its lower expression in endometrium reported earlier.	Histidine	17-19	serum/glucocorticoid regulated kinase 1	Homo sapiens	66-70
27865840-5	2017	The N-terminal fragment of SSH1 bound to and co-localized with F-actin, but mutation at Arg-96 or a Leu-His-Lys (LHK) motif in the PH-like domain reduced this activity.	Histidine	104-107	slingshot protein phosphatase 1	Homo sapiens	27-31
33903307-10	2021	Mutation analysis which was done 70 months after commencement of nilotinib showed the presence of BCRABL1 kinase domain mutation with nucleotide substitution at position 1187 from Histidine(H) to Proline(P) (H396P).	Histidine	180-189	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	98-105
11827471-4	2002	The primary binding site near prgX includes an 11 bp palindromic sequence and showed relatively high affinity for His-tagged PrgX (His-PrgX).	Histidine	114-117	PrgX	Enterococcus faecalis	30-34
33449614-9	2021	The function of the histidine dyad in the HDAC10 mechanism appears to be similar to that in HDAC6, but not HDAC8 in which both functions are served by the second histidine of the tandem pair.	Histidine	20-29	histone deacetylase 10	Homo sapiens	42-48
27870532-2	2017	Although its biological function is uncertain, the iron-sulfur cluster in mitoNEET has been proposed to undergo proton-coupled electron transfer involving the histidine ligand to the cluster.	Histidine	159-168	CDGSH iron sulfur domain 1	Homo sapiens	74-82
33449614-9	2021	The function of the histidine dyad in the HDAC10 mechanism appears to be similar to that in HDAC6, but not HDAC8 in which both functions are served by the second histidine of the tandem pair.	Histidine	162-171	histone deacetylase 10	Homo sapiens	42-48
11827471-4	2002	The primary binding site near prgX includes an 11 bp palindromic sequence and showed relatively high affinity for His-tagged PrgX (His-PrgX).	Histidine	114-117	PrgX	Enterococcus faecalis	125-129
11827471-4	2002	The primary binding site near prgX includes an 11 bp palindromic sequence and showed relatively high affinity for His-tagged PrgX (His-PrgX).	Histidine	114-117	PrgX	Enterococcus faecalis	135-139
11827471-4	2002	The primary binding site near prgX includes an 11 bp palindromic sequence and showed relatively high affinity for His-tagged PrgX (His-PrgX).	Histidine	131-134	PrgX	Enterococcus faecalis	30-34
27870532-5	2017	This work suggests that J values or 15 N isotopic frequency shifts may provide methods for determining experimentally whether the histidine ligand to the oxidized iron-sulfur cluster in human mitoNEET and mitoNEET-related proteins is protonated or deprotonated.	Histidine	130-139	CDGSH iron sulfur domain 1	Homo sapiens	192-200
11827471-4	2002	The primary binding site near prgX includes an 11 bp palindromic sequence and showed relatively high affinity for His-tagged PrgX (His-PrgX).	Histidine	131-134	PrgX	Enterococcus faecalis	125-129
11827471-4	2002	The primary binding site near prgX includes an 11 bp palindromic sequence and showed relatively high affinity for His-tagged PrgX (His-PrgX).	Histidine	131-134	PrgX	Enterococcus faecalis	135-139
27870532-5	2017	This work suggests that J values or 15 N isotopic frequency shifts may provide methods for determining experimentally whether the histidine ligand to the oxidized iron-sulfur cluster in human mitoNEET and mitoNEET-related proteins is protonated or deprotonated.	Histidine	130-139	CDGSH iron sulfur domain 1	Homo sapiens	205-213
33398979-8	2020	After purification by nickel affinity column, the fusion protein His-TIMP-2 was identified by Western blotting method and its biological activity was detected by gelatin zymography.	Histidine	65-68	TIMP metallopeptidase inhibitor 2	Homo sapiens	69-75
28115489-1	2017	BACKGROUND: Although virtually all coronary artery disease associated single-nucleotide polymorphisms identified by genome-wide association studies (GWAS) are in noncoding regions of the genome, a common polymorphism in ZC3HC1 (rs11556924), resulting in an arginine (Arg) to histidine (His) substitution in its encoded protein, NIPA (Nuclear Interacting Partner of Anaplastic Lyphoma Kinase) is linked to a protection from coronary artery disease.	Histidine	275-284	zinc finger C3HC-type containing 1	Homo sapiens	220-226
32656613-10	2020	Recombinant HO1 (rHO1) was successfully induced by 0.1 mmol/l IPTG and purified by Ni-NTA His Bind Resin purification system.	Histidine	90-93	heme oxygenase 1	Rattus norvegicus	12-15
32656613-10	2020	Recombinant HO1 (rHO1) was successfully induced by 0.1 mmol/l IPTG and purified by Ni-NTA His Bind Resin purification system.	Histidine	90-93	heme oxygenase 1	Rattus norvegicus	17-21
14961282-6	2002	A recombinant protein of zebrafish RPA p32 containing a short histidine tag at the NH(2)-terminus was overexpressed in Escherichia coli BL21(DE3) pLys using an inducible T7 expression system, and was purified by Ni-NTA affinity chromatography.	Histidine	62-71	replication protein A2	Danio rerio	35-42
11531342-1	2001	A set of nine variants of yeast iso-1-cytochrome c with zero or one surface histidine have been engineered such that the N-terminal amino group is acetylated in vivo.	Histidine	76-85	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	32-37
28115489-1	2017	BACKGROUND: Although virtually all coronary artery disease associated single-nucleotide polymorphisms identified by genome-wide association studies (GWAS) are in noncoding regions of the genome, a common polymorphism in ZC3HC1 (rs11556924), resulting in an arginine (Arg) to histidine (His) substitution in its encoded protein, NIPA (Nuclear Interacting Partner of Anaplastic Lyphoma Kinase) is linked to a protection from coronary artery disease.	Histidine	286-289	zinc finger C3HC-type containing 1	Homo sapiens	220-226
27406240-1	2017	Arginine 132 (R132) mutations to histidine or cysteine frequently occur to cytosolic NADP+ -isocitrate dehydrogenase (IDH1) in secondary glioblastoma multiforme (GBM) patients, in which GBM develops from a lower grade astroctyoma.	Histidine	33-42	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	118-122
11569620-0	2001	Effects of histidine on working memory deficits induced by the 5-HT1A-receptor agonist 8-OH-DPAT.	Histidine	11-20	5-hydroxytryptamine receptor 1A	Homo sapiens	63-78
32180482-0	2020	Histidine residues at the copper-binding site in human tyrosinase are essential for its catalytic activities.	Histidine	0-9	tyrosinase	Homo sapiens	55-65
27872244-8	2017	The most prominent network-guided GWAS signal was for a histidine (His)-related trait in a region containing two genes: a cationic amino acid transporter (CAT4) and a polynucleotide phosphorylase resistant to inhibition with fosmidomycin.	Histidine	56-65	cationic amino acid transporter 4	Arabidopsis thaliana	155-159
33096938-7	2020	The CXCR4 protein used in this assay was produced with a C-terminal 10x-histidine tag and was immobilized on a nitrilotriacetic acid chip.	Histidine	72-81	C-X-C motif chemokine receptor 4	Homo sapiens	4-9
11444980-7	2001	The active site general-base implicated by these kinetic results is believed to be His-334, of the highly conserved TGase Cys-His-Asp catalytic triad.	Histidine	83-86	protein-glutamine gamma-glutamyltransferase 2	Cavia porcellus	116-121
11444980-7	2001	The active site general-base implicated by these kinetic results is believed to be His-334, of the highly conserved TGase Cys-His-Asp catalytic triad.	Histidine	126-129	protein-glutamine gamma-glutamyltransferase 2	Cavia porcellus	116-121
11337504-4	2001	We previously identified His-193 of rat GCS as an important residue in UDP-Glc and GCS inhibitor binding; however, little else is known about the GCS active site.	Histidine	25-28	UDP-glucose ceramide glucosyltransferase	Rattus norvegicus	40-43
11337504-4	2001	We previously identified His-193 of rat GCS as an important residue in UDP-Glc and GCS inhibitor binding; however, little else is known about the GCS active site.	Histidine	25-28	UDP-glucose ceramide glucosyltransferase	Rattus norvegicus	83-86
11337504-4	2001	We previously identified His-193 of rat GCS as an important residue in UDP-Glc and GCS inhibitor binding; however, little else is known about the GCS active site.	Histidine	25-28	UDP-glucose ceramide glucosyltransferase	Rattus norvegicus	83-86
33025907-0	2020	Feedback control of Wnt signaling based on ultrastable histidine cluster co-aggregation between Naked/NKD and Axin.	Histidine	55-64	axin 1	Homo sapiens	110-114
33025907-6	2020	Naked/NKD HisC cores co-aggregate with a conserved histidine cluster within Axin, to destabilize it along with Dishevelled, possibly via the autophagy receptor p62 which binds to HisC aggregates.	Histidine	51-60	axin 1	Homo sapiens	76-80
33025907-6	2020	Naked/NKD HisC cores co-aggregate with a conserved histidine cluster within Axin, to destabilize it along with Dishevelled, possibly via the autophagy receptor p62 which binds to HisC aggregates.	Histidine	51-60	nucleoporin 62	Homo sapiens	160-163
27872244-8	2017	The most prominent network-guided GWAS signal was for a histidine (His)-related trait in a region containing two genes: a cationic amino acid transporter (CAT4) and a polynucleotide phosphorylase resistant to inhibition with fosmidomycin.	Histidine	67-70	cationic amino acid transporter 4	Arabidopsis thaliana	155-159
27789710-3	2016	To shed light on the mechanistic basis for these observations, we determined the crystal structure of SpvD and show that it adopts a papain-like fold with a characteristic cysteine-histidine-aspartate catalytic triad comprising Cys-73, His-162, and Asp-182.	Histidine	181-190	Salmonella plasmid virulence protein D	Salmonella enterica subsp. enterica serovar Typhimurium	102-106
32962355-4	2020	As a cysteine protease, PLpro is rich in cysteines and histidines, and their protonation/deprotonation modulates catalysis and conformational plasticity.	Histidine	55-65	cathepsin B	Homo sapiens	5-22
11337504-7	2001	Next, we showed by multiple alignment that the region of GCS flanking His-193 and Cys-207 (amino acids 89-278) contains a D1,D2,D3,(Q/R)XXRW motif found in the putative active site of processive beta-glycosyltransferases (e.g. cellulose, chitin, and hyaluronan synthases).	Histidine	70-73	UDP-glucose ceramide glucosyltransferase	Rattus norvegicus	57-60
27789710-3	2016	To shed light on the mechanistic basis for these observations, we determined the crystal structure of SpvD and show that it adopts a papain-like fold with a characteristic cysteine-histidine-aspartate catalytic triad comprising Cys-73, His-162, and Asp-182.	Histidine	236-239	Salmonella plasmid virulence protein D	Salmonella enterica subsp. enterica serovar Typhimurium	102-106
11343793-0	2001	The importance of histidine residues in human ecto-nucleoside triphosphate diphosphohydrolase-3 as determined by site-directed mutagenesis.	Histidine	18-27	ectonucleoside triphosphate diphosphohydrolase 3	Homo sapiens	46-95
32664451-1	2020	Carnosinase 1 (CN1) is encoded by the Cndp1 gene and degrades carnosine and anserine, two natural histidine-containing dipeptides.	Histidine	98-107	carnosine dipeptidase 1 (metallopeptidase M20 family)	Mus musculus	0-13
27933794-1	2016	Histone deacetylase 8 (HDAC8) catalyzes the hydrolysis of acetyl-l-lysine to yield products l-lysine and acetate through a mechanism in which a nucleophilic water molecule is activated by a histidine general base and a catalytic metal ion (Zn2+ or Fe2+).	Histidine	190-199	histone deacetylase 8	Homo sapiens	0-21
32664451-1	2020	Carnosinase 1 (CN1) is encoded by the Cndp1 gene and degrades carnosine and anserine, two natural histidine-containing dipeptides.	Histidine	98-107	carnosine dipeptidase 1 (metallopeptidase M20 family)	Mus musculus	15-18
32664451-1	2020	Carnosinase 1 (CN1) is encoded by the Cndp1 gene and degrades carnosine and anserine, two natural histidine-containing dipeptides.	Histidine	98-107	carnosine dipeptidase 1 (metallopeptidase M20 family)	Mus musculus	38-43
11154690-3	2001	An enzymatic mechanism involving a catalytic metal ion, a Glu/His catalytic dyad, and a charged oxyanion hole was previously proposed based on recently determined FAH crystal structures.	Histidine	62-65	fumarylacetoacetate hydrolase	Homo sapiens	163-166
27933794-1	2016	Histone deacetylase 8 (HDAC8) catalyzes the hydrolysis of acetyl-l-lysine to yield products l-lysine and acetate through a mechanism in which a nucleophilic water molecule is activated by a histidine general base and a catalytic metal ion (Zn2+ or Fe2+).	Histidine	190-199	histone deacetylase 8	Homo sapiens	23-28
27758865-2	2016	Recent studies have shown that PCSK9 lacking its Cys/His-rich domain can still promote LDLR internalization, but the complex does not reach the lysosome suggesting the presence of an additional interaction partner(s).	Histidine	53-56	proprotein convertase subtilisin/kexin type 9	Homo sapiens	31-36
11278504-9	2001	All four histidine mutants had k(cat) values 1000-fold lower than wild-type CNP-CF, but K(m) values were similar.	Histidine	9-18	2',3'-cyclic nucleotide 3' phosphodiesterase	Rattus norvegicus	76-79
11325944-7	2001	The portion of GST-Bc responsible for the interference phenotype was localized using truncation, linker insertion, and point mutations to the region between residues 293 and 366 flanking His-313, the putative site of autophosphorylation.	Histidine	187-190	glutathione S-transferase kappa 1	Homo sapiens	15-18
11325944-12	2001	Reverse transfer of phosphate from P-UhpA to GST-Bc was observed in the presence of the metal chelator EDTA and depended on the presence of His-313.	Histidine	140-143	glutathione S-transferase kappa 1	Homo sapiens	45-48
32432920-6	2020	Trachealis smooth muscle tissues were stimulated with recombinant His-S100A4 and the effects on inflammatory responses were evaluated.	Histidine	66-69	S100 calcium binding protein A4	Homo sapiens	70-76
32637952-4	2020	As a cysteine protease, PLpro is rich in cysteines and histidines and their protonation/deprotonation modulates catalysis and conformational plasticity.	Histidine	55-65	cathepsin B	Homo sapiens	5-22
27750195-13	2016	As well, it was shown that the extra cellular acidosis led to the protonation of the TRAIL residue histidine by flipping the His switch to the on position with a concomitant decrease in affinity for DR4 and DR5 receptors.	Histidine	99-108	TNF receptor superfamily member 10b	Homo sapiens	207-210
32265297-10	2020	Interestingly, in OTUB2, the catalytic residues His-224 and Asn-226 formed a stable hydrogen bond.	Histidine	48-51	OTU deubiquitinase, ubiquitin aldehyde binding 2	Homo sapiens	18-23
32483417-12	2020	Using a nude mouse xenograft model, we verified that inhibiting JMJD2B could decrease the levels of amino acids (Asn, Phe, His).	Histidine	123-126	lysine (K)-specific demethylase 4B	Mus musculus	64-70
11069919-6	2001	Although a AtCCME (Met(79)-Ser(256)) is not fully able to complement an Escherichia coli CcmE mutant strain for bacterial holocytochrome c production, it is able to bind heme covalently through a conserved histidine, a feature previously shown for E. coli CcmE.	Histidine	206-215	transmembrane protein G1P-related 1	Arabidopsis thaliana	11-17
11069919-6	2001	Although a AtCCME (Met(79)-Ser(256)) is not fully able to complement an Escherichia coli CcmE mutant strain for bacterial holocytochrome c production, it is able to bind heme covalently through a conserved histidine, a feature previously shown for E. coli CcmE.	Histidine	206-215	transmembrane protein G1P-related 1	Arabidopsis thaliana	256-260
27543355-0	2016	Circumvention of P-gp and MRP2 mediated efflux of lopinavir by a histidine based dipeptide prodrug.	Histidine	65-74	phosphoglycolate phosphatase	Homo sapiens	17-21
11148031-0	2001	Solution structure and dynamic character of the histidine-containing phosphotransfer domain of anaerobic sensor kinase ArcB from Escherichia coli.	Histidine	48-57	hypothetical protein	Escherichia coli	119-123
11148031-2	2001	Multidimensional NMR techniques were applied to determine the solution structure of the histidine-containing phosphotransfer signaling domain of ArcB (HPt(ArcB)), which has a phosphorylation site, His717.	Histidine	88-97	hypothetical protein	Escherichia coli	145-149
11148031-2	2001	Multidimensional NMR techniques were applied to determine the solution structure of the histidine-containing phosphotransfer signaling domain of ArcB (HPt(ArcB)), which has a phosphorylation site, His717.	Histidine	88-97	hypothetical protein	Escherichia coli	151-160
11148034-1	2001	We have explored the ability of a nucleoside diphosphate kinase (NDPK) mutant in which the nucleophilic histidine has been replaced by glycine (H122G) to transfer phosphate from ATP to alcohols of varying pK(a), size, shape, and polarity.	Histidine	104-113	cytidine/uridine monophosphate kinase 2	Homo sapiens	34-63
32181671-0	2020	Molecular Dynamics Simulations Based on Newly Developed Force Field Parameters for Cu2+ Spin Labels Provide Insights Into Double Histidine-Based Double Electron-Electron Resonance.	Histidine	129-138	spindlin 1	Homo sapiens	88-92
32181671-1	2020	Electron paramagnetic resonance (EPR) in combination with the recently developed double Histidine (dHis) based Cu(II) spin labeling has provided valuable insights into protein structure and conformational dynamics.	Histidine	88-97	spindlin 1	Homo sapiens	118-122
31827252-1	2020	HARS2 encodes mitochondrial histidyl-tRNA synthetase (HARS2), which links histidine to its cognate tRNA in the mitochondrial matrix.	Histidine	74-83	histidyl-tRNA synthetase 2, mitochondrial	Homo sapiens	0-5
27543355-9	2016	[3H]-GlySar and [3H]-l-His uptake receded to approximately 30% in the presence of His-Leu-LPV supporting the PepT1/PHT1 mediated uptake process.	Histidine	21-26	solute carrier family 15 member 4	Homo sapiens	115-119
31827252-1	2020	HARS2 encodes mitochondrial histidyl-tRNA synthetase (HARS2), which links histidine to its cognate tRNA in the mitochondrial matrix.	Histidine	74-83	histidyl-tRNA synthetase 1	Homo sapiens	28-52
27543355-9	2016	[3H]-GlySar and [3H]-l-His uptake receded to approximately 30% in the presence of His-Leu-LPV supporting the PepT1/PHT1 mediated uptake process.	Histidine	23-26	solute carrier family 15 member 4	Homo sapiens	115-119
31827252-1	2020	HARS2 encodes mitochondrial histidyl-tRNA synthetase (HARS2), which links histidine to its cognate tRNA in the mitochondrial matrix.	Histidine	74-83	histidyl-tRNA synthetase 2, mitochondrial	Homo sapiens	54-59
11148034-1	2001	We have explored the ability of a nucleoside diphosphate kinase (NDPK) mutant in which the nucleophilic histidine has been replaced by glycine (H122G) to transfer phosphate from ATP to alcohols of varying pK(a), size, shape, and polarity.	Histidine	104-113	cytidine/uridine monophosphate kinase 2	Homo sapiens	65-69
31493373-5	2019	In this work, we characterized a highly conserved histidine (H208), present at TM5-ICL3 region of T2R14 and its role in agonist-induced T2R14 signaling.	Histidine	50-59	tropomyosin 3	Homo sapiens	79-82
27470567-14	2016	Finally, tilianin docking studies with PPARalpha showed polar interactions with Glu269, Tyr314, His 440 and Tyr464 residues.	Histidine	96-99	peroxisome proliferator activated receptor alpha	Rattus norvegicus	39-48
11115608-4	2001	NS1 bound to the two related cysteine-histidine-rich regions of CBP, referred to as C/H1 and C/H3, the former of which has an antagonistic function to CBP upon the NS1-transactivation.	Histidine	38-47	SUN domain containing ossification factor	Homo sapiens	84-97
11082187-3	2000	Six specific His-CDC2aAt-binding phage clones (3D1, 3D2, 3D10, 3D25, 4D21 and 4D47) were isolated by panning.	Histidine	13-16	cell division control 2	Arabidopsis thaliana	17-24
11082187-4	2000	The isolated monoclonal phage clones, as well as the soluble scFv fragments produced in the periplasm of Escherichia coli, bind His-CDC2aAt in ELISA and on Western blots.	Histidine	128-131	cell division control 2	Arabidopsis thaliana	132-139
31757046-0	2019	Probing the Interactions of Sulfur-Containing Histidine Compounds with Human Gamma-Glutamyl Transpeptidase.	Histidine	46-55	inactive glutathione hydrolase 2	Homo sapiens	77-106
27522067-9	2016	Conversely, two substitutions (distal-Thr to Ser and distal-His to Tyr) were sufficient to bestow IDO1-like high affinity on ancestral and chicken IDO2.	Histidine	60-63	indoleamine 2,3-dioxygenase 1	Homo sapiens	98-102
10958790-2	2000	MTF-1 contains six zinc fingers of the Cys(2)-His(2) type.	Histidine	46-49	metal response element binding transcription factor 1	Mus musculus	0-5
10958787-0	2000	Interactions of Cdk7 and Kin28 with Hint/PKCI-1 and Hnt1 histidine triad proteins.	Histidine	57-66	TFIIH complex serine/threonine-protein kinase subunit KIN28	Saccharomyces cerevisiae S288C	25-30
10958787-6	2000	The physical and genetic interactions of Hint and Hnt1 with Cdk7 and Kin28 suggest a role for this class of histidine triad proteins in the regulation of Cdk7 and Kin28 functions.	Histidine	108-117	TFIIH complex serine/threonine-protein kinase subunit KIN28	Saccharomyces cerevisiae S288C	69-74
10958787-6	2000	The physical and genetic interactions of Hint and Hnt1 with Cdk7 and Kin28 suggest a role for this class of histidine triad proteins in the regulation of Cdk7 and Kin28 functions.	Histidine	108-117	TFIIH complex serine/threonine-protein kinase subunit KIN28	Saccharomyces cerevisiae S288C	163-168
31722196-6	2019	Metabolic profiling of fly heads revealed that loss of dMyc and its overexpression alter steady-state metabolite levels and have opposing effects on histidine, the histamine precursor, which is rescued in dMyc mutants by ablation of dMnt and could contribute to effects of dMyc on locomotor behavior.	Histidine	149-158	Myc	Drosophila melanogaster	55-59
27522067-9	2016	Conversely, two substitutions (distal-Thr to Ser and distal-His to Tyr) were sufficient to bestow IDO1-like high affinity on ancestral and chicken IDO2.	Histidine	60-63	indoleamine 2,3-dioxygenase 2	Homo sapiens	147-151
31722196-6	2019	Metabolic profiling of fly heads revealed that loss of dMyc and its overexpression alter steady-state metabolite levels and have opposing effects on histidine, the histamine precursor, which is rescued in dMyc mutants by ablation of dMnt and could contribute to effects of dMyc on locomotor behavior.	Histidine	149-158	Myc	Drosophila melanogaster	205-209
31722196-6	2019	Metabolic profiling of fly heads revealed that loss of dMyc and its overexpression alter steady-state metabolite levels and have opposing effects on histidine, the histamine precursor, which is rescued in dMyc mutants by ablation of dMnt and could contribute to effects of dMyc on locomotor behavior.	Histidine	149-158	Myc	Drosophila melanogaster	205-209
27346274-9	2016	Mutagenesis of each amino acid difference in EC1 between BB3 receptor/BB2 receptor showed replacement of His(107) in BB3 receptor by Lys(107) (H107K-BB3 receptor-mutant) from BB2 receptor, decreased affinity 60-fold, and three replacements [H107K, E11D, G112R] decreased affinity 500-fold.	Histidine	105-108	Susceptibility to lysis by alloreactive natural killer cells	Homo sapiens	45-48
11078388-4	2000	Chronic LU135252 treatment completely prevented activation of renal ACE activity (13.3 +/- 0.3 His-Leu/mg protein nmol/l, p &lt; 0.05) independent of ACE mRNA expression or renal ET-1 protein levels.	Histidine	95-98	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	68-71
27405756-7	2016	Remarkably, residue His-207 alone is sufficient to hydrolyze PGP, indicating a specific catalytic mechanism for PgpB in PG biosynthesis.	Histidine	20-23	phosphoglycolate phosphatase	Homo sapiens	61-64
11065275-1	2000	Human annexin V cDNA was cloned into plasmid pET19b and fused to a ten consecutive histidine tag at N-terminal.	Histidine	83-92	annexin A5	Homo sapiens	6-15
31273981-9	2019	Analysis of a peptide maquette derived from the N-terminus of HypA revealed that nickel is predominately coordinated by atoms from the N-terminal Met-His motif.	Histidine	150-153	hypA	Escherichia coli	62-66
31569521-2	2019	Its lipid inhibition effects indicated that the synthetic peptide PP1 exhibits a good inhibitory effect against porcine pancreatic lipase (PL) (47.95%) at 200 mug/mL, which could be attributed to its hydrogen binding into catalytic sites of PL (Ser153, Asp177, and His 264) by docking analysis.	Histidine	265-268	pancreatic lipase	Mus musculus	120-137
10913119-3	2000	The phosphoryl group is transferred from one domain to another, with histidine as the phosphoryl acceptor in IIA and cysteine as the acceptor in certain IIB domains.	Histidine	69-78	colicin Ia immunity protein	Escherichia coli	109-112
27542194-2	2016	KCa3.1 is unique among these four channels in that activation requires, in addition to calcium, phosphorylation of a single histidine residue (His358) in the cytoplasmic region, by nucleoside diphosphate kinase-B (NDPK-B).	Histidine	124-133	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	181-212
27247265-3	2016	Previous in vitro studies revealed that palmitoylation of NCAM is required for fibroblast growth factor 2 (FGF2)-stimulated neurite outgrowth and identified the zinc finger DHHC (Asp-His-His-Cys)-containing proteins ZDHHC3 and ZDHHC7 as specific NCAM-palmitoylating enzymes.	Histidine	183-186	neural cell adhesion molecule 1	Homo sapiens	58-62
31366154-4	2019	Genetically programming sGFP and RFP with Cys-tag and His-tag, respectively, allowed tuning the protein spatial organization either across the porous structure of two microbeads with different functional groups (agarose-based materials activated with metal chelates and epoxy-methacrylate materials) or across the surface of a single microbead functionalized with both metal-chelates and disulfide groups.	Histidine	54-57	tripartite motif containing 27	Homo sapiens	33-36
27247265-3	2016	Previous in vitro studies revealed that palmitoylation of NCAM is required for fibroblast growth factor 2 (FGF2)-stimulated neurite outgrowth and identified the zinc finger DHHC (Asp-His-His-Cys)-containing proteins ZDHHC3 and ZDHHC7 as specific NCAM-palmitoylating enzymes.	Histidine	183-186	zinc finger DHHC-type palmitoyltransferase 3	Homo sapiens	216-222
11012667-2	2000	Complete exchange was observed with histidine-tagged derivatives of LC17a, LC17b and E122A-LC17a (LC17a and LC17b are the usual constituants of smooth muscle myosin), with small changes in the ATPase activity of reconstituted myosins.	Histidine	36-45	myosin heavy chain 14	Homo sapiens	158-164
27247265-3	2016	Previous in vitro studies revealed that palmitoylation of NCAM is required for fibroblast growth factor 2 (FGF2)-stimulated neurite outgrowth and identified the zinc finger DHHC (Asp-His-His-Cys)-containing proteins ZDHHC3 and ZDHHC7 as specific NCAM-palmitoylating enzymes.	Histidine	183-186	neural cell adhesion molecule 1	Homo sapiens	246-250
27247265-3	2016	Previous in vitro studies revealed that palmitoylation of NCAM is required for fibroblast growth factor 2 (FGF2)-stimulated neurite outgrowth and identified the zinc finger DHHC (Asp-His-His-Cys)-containing proteins ZDHHC3 and ZDHHC7 as specific NCAM-palmitoylating enzymes.	Histidine	187-190	neural cell adhesion molecule 1	Homo sapiens	58-62
27247265-3	2016	Previous in vitro studies revealed that palmitoylation of NCAM is required for fibroblast growth factor 2 (FGF2)-stimulated neurite outgrowth and identified the zinc finger DHHC (Asp-His-His-Cys)-containing proteins ZDHHC3 and ZDHHC7 as specific NCAM-palmitoylating enzymes.	Histidine	187-190	zinc finger DHHC-type palmitoyltransferase 3	Homo sapiens	216-222
31284551-4	2019	In this work, we have synthesized new histidine-rich lysine-based dendrimers (Lys-2His dendrimer) with two linear histidine (His) residues in every inner segment.	Histidine	38-47	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	Homo sapiens	78-83
31284551-4	2019	In this work, we have synthesized new histidine-rich lysine-based dendrimers (Lys-2His dendrimer) with two linear histidine (His) residues in every inner segment.	Histidine	114-123	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	Homo sapiens	78-83
27247265-3	2016	Previous in vitro studies revealed that palmitoylation of NCAM is required for fibroblast growth factor 2 (FGF2)-stimulated neurite outgrowth and identified the zinc finger DHHC (Asp-His-His-Cys)-containing proteins ZDHHC3 and ZDHHC7 as specific NCAM-palmitoylating enzymes.	Histidine	187-190	neural cell adhesion molecule 1	Homo sapiens	246-250
10975859-4	2000	Both caspase-3 inhibitor Z-Asp(OCH3)-Glu(OCH3)-Val-Asp(OCH3)-CH2F and caspase-9 inhibitor Z-Leu-Glu(OCH3)-His-Asp(OCH3)-CH2F prevented the chondrocyte death.	Histidine	106-109	caspase 9	Homo sapiens	70-79
27416303-7	2016	A mutant form of PAI-1 lacking two N-terminal histidine residues at positions 2 and 3 exhibits similar increases in dynamics upon Cu(II) binding compared to that of active wild-type PAI-1, indicating that the observed structural effects are not a result of coordination of Cu(II) to these histidine residues.	Histidine	289-298	serpin family E member 1	Homo sapiens	17-22
26928127-0	2016	Ypq3p-dependent histidine uptake by the vacuolar membrane vesicles of Saccharomyces cerevisiae.	Histidine	16-25	cationic amino acid transporter	Saccharomyces cerevisiae S288C	0-5
10972987-3	2000	NP/NMP4 are nuclear matrix proteins that contain from five to eight Cys(2)His(2) zinc fingers.	Histidine	74-77	zinc finger protein 384	Rattus norvegicus	3-7
31164399-0	2019	The histidine-rich loop in the extracellular domain of ZIP4 binds zinc and plays a role in zinc transport.	Histidine	4-13	solute carrier family 39 member 4	Homo sapiens	55-59
31164399-4	2019	In this work, we examined zinc binding to the isolated ZIP4-ECD from Pteropus Alecto (black fruit bat) and located zinc-binding sites with a low micromolar affinity within a histidine-rich loop ubiquitously present in ZIP4 proteins.	Histidine	174-183	solute carrier family 39 member 4	Homo sapiens	55-59
31164399-4	2019	In this work, we examined zinc binding to the isolated ZIP4-ECD from Pteropus Alecto (black fruit bat) and located zinc-binding sites with a low micromolar affinity within a histidine-rich loop ubiquitously present in ZIP4 proteins.	Histidine	174-183	solute carrier family 39 member 4	Homo sapiens	218-222
31164399-6	2019	Mutagenesis and functional study on human ZIP4 by using an improved cell-based zinc uptake assay indicated that the histidine residues within this loop are not involved in preselection of metal substrate but play a role in promoting zinc transport.	Histidine	116-125	solute carrier family 39 member 4	Homo sapiens	42-46
26928127-5	2016	These results suggest that Ypq3p is specifically involved in the vacuolar uptake of histidine in S. cerevisiae.	Histidine	84-93	cationic amino acid transporter	Saccharomyces cerevisiae S288C	27-32
10816589-10	2000	Replacement of the amino-terminal His residue by Ala abolishes the ability of KIR2DL1 to bind Co(2+), indicating that Co(2+)-mediated KIR2DL1 dimerization involves pairing of the D1 domain.	Histidine	34-37	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1	Homo sapiens	78-85
26928127-6	2016	The cellular level of Ypq3p-HA(3) was enhanced by depletion of histidine from culture medium, suggesting that it is regulated by the substrate.	Histidine	63-72	cationic amino acid transporter	Saccharomyces cerevisiae S288C	22-27
10816589-10	2000	Replacement of the amino-terminal His residue by Ala abolishes the ability of KIR2DL1 to bind Co(2+), indicating that Co(2+)-mediated KIR2DL1 dimerization involves pairing of the D1 domain.	Histidine	34-37	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1	Homo sapiens	134-141
27159451-8	2016	The structure explains how diphthamide, a eukaryotic and archaeal specific post-translational modification of a histidine residue of eEF2, is involved in translocation.	Histidine	112-121	eukaryotic translation elongation factor 2	Homo sapiens	133-137
10920044-7	2000	In addition to the C2-proton (H epsilon(1)) chemical shifts, these spectra also reveal the corresponding C4-proton (H delta(2)) resonances, correlated with the N epsilon(2) and N delta(1) chemical shifts of all 13 surface histidines per alpha beta dimer.	Histidine	222-232	delta like canonical Notch ligand 4	Homo sapiens	116-126
31000629-6	2019	Here we used RNA chemical footprinting and binding assays to test this model and further probe the molecular basis for the requirement for two critical tRNA-interacting residues, His-152 and Lys-187, in the context of human Thg1 (hThg1).	Histidine	179-182	tRNA-histidine guanylyltransferase 1 like	Homo sapiens	224-228
31000629-6	2019	Here we used RNA chemical footprinting and binding assays to test this model and further probe the molecular basis for the requirement for two critical tRNA-interacting residues, His-152 and Lys-187, in the context of human Thg1 (hThg1).	Histidine	179-182	tRNA-histidine guanylyltransferase 1 like	Homo sapiens	230-235
30879301-3	2019	Our chemogenetic experiments demonstrate that the highly conserved cysteine and histidine residues within the C-X8-C-X24-75-H-X-G-G-H motif of the TLF domain of Apd1 and Aim32 proteins are essential for viability of yeast cells upon treatment with the redox mediators gallobenzophenone or pyrogallol, respectively.	Histidine	80-89	Apd1p	Saccharomyces cerevisiae S288C	161-165
30879301-3	2019	Our chemogenetic experiments demonstrate that the highly conserved cysteine and histidine residues within the C-X8-C-X24-75-H-X-G-G-H motif of the TLF domain of Apd1 and Aim32 proteins are essential for viability of yeast cells upon treatment with the redox mediators gallobenzophenone or pyrogallol, respectively.	Histidine	80-89	Aim32p	Saccharomyces cerevisiae S288C	170-175
30879301-6	2019	Apd1 and its engineered variants represent an unprecedented flexible system for which a stable [2Fe-2S] cluster with two histidine ligands, (two different) single histidine ligands, or only cysteinyl ligands is possible in the same protein fold.	Histidine	121-130	Apd1p	Saccharomyces cerevisiae S288C	0-4
30879301-6	2019	Apd1 and its engineered variants represent an unprecedented flexible system for which a stable [2Fe-2S] cluster with two histidine ligands, (two different) single histidine ligands, or only cysteinyl ligands is possible in the same protein fold.	Histidine	163-172	Apd1p	Saccharomyces cerevisiae S288C	0-4
27010847-3	2016	Analysis of the crystal CGL structures bound to galactose, galactosamine, and globotriose Gb3 indicated that each CGL can bind three ligands through a carbohydrate-binding motif involving an extensive histidine- and water-mediated hydrogen bond network.	Histidine	201-210	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	90-93
30969963-2	2019	Here we determined the evolutionarily-relevant segment of the fitness landscape of His3, a gene coding for an enzyme in the histidine synthesis pathway, focusing on combinations of amino acid states found at orthologous sites of extant species.	Histidine	124-133	imidazoleglycerol-phosphate dehydratase HIS3	Saccharomyces cerevisiae S288C	83-87
10964987-14	2000	In contrast, the N-terminal histidine-tagged fusion protein bound IL3 receptor with a 10-fold lower affinity and was 10-fold less cytotoxic to IL3 receptor positive blasts.	Histidine	28-37	interleukin 3	Homo sapiens	66-69
10964987-14	2000	In contrast, the N-terminal histidine-tagged fusion protein bound IL3 receptor with a 10-fold lower affinity and was 10-fold less cytotoxic to IL3 receptor positive blasts.	Histidine	28-37	interleukin 3	Homo sapiens	143-146
10908322-15	2000	Taken together the results show that the mutant forms alpha-hOgg1-Gln(46) and alpha-hOgg1-His(154) found in human tumors are defective in their catalytic capacities.	Histidine	90-93	8-oxoguanine DNA glycosylase	Homo sapiens	60-65
10908322-15	2000	Taken together the results show that the mutant forms alpha-hOgg1-Gln(46) and alpha-hOgg1-His(154) found in human tumors are defective in their catalytic capacities.	Histidine	90-93	8-oxoguanine DNA glycosylase	Homo sapiens	84-89
26826131-1	2016	Rpl3, a highly conserved ribosomal protein, is methylated at histidine 243 by the Hpm1 methyltransferase in Saccharomyces cerevisiae.	Histidine	61-70	protein-histidine N-methyltransferase	Saccharomyces cerevisiae S288C	82-86
10947842-0	2000	Tuning of the porin expression under anaerobic growth conditions by his-to-Asp cross-phosphorelay through both the EnvZ-osmosensor and ArcB-anaerosensor in Escherichia coli.	Histidine	68-71	hypothetical protein	Escherichia coli	135-139
30804004-0	2019	Histidine is selectively required for the growth of Myc-dependent dedifferentiation tumours in the Drosophila CNS.	Histidine	0-9	Myc	Drosophila melanogaster	52-55
30804004-4	2019	The reliance of tumours on dietary histidine and also on histidine decarboxylase (Hdc) depends upon their growth requirement for Myc.	Histidine	35-44	Myc	Drosophila melanogaster	129-132
30804004-5	2019	We demonstrate that Myc overexpression in nerfin-1 tumours is sufficient to switch their mode of growth from histidine/Hdc sensitive to resistant.	Histidine	109-118	Myc	Drosophila melanogaster	20-23
30785395-5	2019	In conclusion, this study is the first to show a catalytic mechanism of SETD3-mediated histidine methylation on beta-actin, which not only throws light on the protein histidine methylation phenomenon but also facilitates the design of small molecule inhibitors of SETD3.	Histidine	87-96	POTE ankyrin domain family member F	Homo sapiens	112-122
30785395-5	2019	In conclusion, this study is the first to show a catalytic mechanism of SETD3-mediated histidine methylation on beta-actin, which not only throws light on the protein histidine methylation phenomenon but also facilitates the design of small molecule inhibitors of SETD3.	Histidine	167-176	POTE ankyrin domain family member F	Homo sapiens	112-122
11204523-2	2000	The substitution of arginine (R) to histidine (H) at amino acid residue 156 (R156H) of coiled 1A region is one of the most frequent mutations of KRT10.	Histidine	36-45	keratin 10	Homo sapiens	145-150
27030405-5	2016	Molecular modeling analysis reveals that the glutamic acid, which is negatively charged, interacts with positively charged histidine located at position 55, thereby stabilizing KIR2DL2/L3 dimer and reducing entropy loss when KIR2DL2/3 binds to HLA-C ligand.	Histidine	123-132	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 2	Homo sapiens	177-184
10764763-1	2000	The contribution of Arg(129) of the serpin, antithrombin, to the mechanism of allosteric activation of the protein by heparin was determined from the effect of mutating this residue to either His or Gln.	Histidine	192-195	serpin family C member 1	Homo sapiens	44-56
10843688-5	2000	A histidine-tagged form of porcine sB7-1 (sB7-1-His) interacted with both CD28 and CTLA-4, and effectively blocked IL-2 production from human responder cells stimulated with PHA and either porcine or human stimulator cells.	Histidine	2-11	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	83-89
30455352-1	2019	Hsp70 chaperones are central hubs of the protein quality control network and collaborate with co-chaperones having a J-domain (an ~70-residue-long helical hairpin with a flexible loop and a conserved His-Pro-Asp motif required for ATP hydrolysis by Hsp70s) and also with nucleotide exchange factors to facilitate many protein-folding processes that (re)establish protein homeostasis.	Histidine	200-203	heat shock protein family A (Hsp70) member 4	Homo sapiens	0-5
27030405-5	2016	Molecular modeling analysis reveals that the glutamic acid, which is negatively charged, interacts with positively charged histidine located at position 55, thereby stabilizing KIR2DL2/L3 dimer and reducing entropy loss when KIR2DL2/3 binds to HLA-C ligand.	Histidine	123-132	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 2	Homo sapiens	225-232
30535142-4	2019	Using CRISPR knockout, we show that CRHR1 is necessary for acid-induced POMC expression, and this induction is mediated by CRHR1 histidine residues and calmodulin-dependent protein kinase II in both pituitary corticotroph cells and in nonpituitary cell lines expressing ectopic ACTH.	Histidine	129-138	corticotropin releasing hormone receptor 1	Mus musculus	123-128
26984496-5	2016	A recombinant histidine-tagged sPRR (sPRR-His) in the nanomolar range induced a remarkable increase in the abundance of renal aquaporin 2 (AQP2) protein in primary rat inner medullary collecting duct cells.	Histidine	14-23	small proline-rich protein 1A	Rattus norvegicus	31-35
30554660-5	2019	GST-SSL5 was found to attenuate the inhibitory activity of recombinant histidine-tagged C1Inh (C1Inh-His) toward complement C1s.	Histidine	71-80	serpin family G member 1	Homo sapiens	88-93
30554660-5	2019	GST-SSL5 was found to attenuate the inhibitory activity of recombinant histidine-tagged C1Inh (C1Inh-His) toward complement C1s.	Histidine	71-80	serpin family G member 1	Homo sapiens	95-104
30697165-4	2018	Both necroptosis inhibitors of RIPK1 and RIPK3 and a necroptosis activator/apoptosis inhibitor z-VAD increased cell death caused by L-histidine, but not L-arginine or L-ornithine.	Histidine	132-143	receptor-interacting serine-threonine kinase 3	Mus musculus	41-46
10818253-1	2000	The abundance of a histidine residue at position 185 (His(185)) of the human corticotropin-releasing factor (CRF) type 2 alpha receptor (hCRF(2alpha)) was investigated.	Histidine	19-28	corticotropin releasing hormone	Homo sapiens	77-107
10818253-1	2000	The abundance of a histidine residue at position 185 (His(185)) of the human corticotropin-releasing factor (CRF) type 2 alpha receptor (hCRF(2alpha)) was investigated.	Histidine	19-28	corticotropin releasing hormone	Homo sapiens	137-141
10818253-1	2000	The abundance of a histidine residue at position 185 (His(185)) of the human corticotropin-releasing factor (CRF) type 2 alpha receptor (hCRF(2alpha)) was investigated.	Histidine	54-57	corticotropin releasing hormone	Homo sapiens	77-107
10818253-1	2000	The abundance of a histidine residue at position 185 (His(185)) of the human corticotropin-releasing factor (CRF) type 2 alpha receptor (hCRF(2alpha)) was investigated.	Histidine	54-57	corticotropin releasing hormone	Homo sapiens	137-141
26984496-5	2016	A recombinant histidine-tagged sPRR (sPRR-His) in the nanomolar range induced a remarkable increase in the abundance of renal aquaporin 2 (AQP2) protein in primary rat inner medullary collecting duct cells.	Histidine	14-23	small proline-rich protein 1A	Rattus norvegicus	37-41
10833400-8	2000	The plant-produced GM-CSF was biologically active and could be bound to a nickel affinity matrix, indicating that both the receptor-binding region and the 6-His tag were functional.	Histidine	157-160	colony stimulating factor 2	Homo sapiens	19-25
29499210-9	2018	The N-terminal histidine-rich segment may be essential for neo-functionalization (i.e., high-affinity T3 binding activity) of an ancient TTR after gene duplication.	Histidine	15-24	transthyretin	Homo sapiens	137-140
26984496-5	2016	A recombinant histidine-tagged sPRR (sPRR-His) in the nanomolar range induced a remarkable increase in the abundance of renal aquaporin 2 (AQP2) protein in primary rat inner medullary collecting duct cells.	Histidine	14-23	aquaporin 2	Rattus norvegicus	126-137
26984496-5	2016	A recombinant histidine-tagged sPRR (sPRR-His) in the nanomolar range induced a remarkable increase in the abundance of renal aquaporin 2 (AQP2) protein in primary rat inner medullary collecting duct cells.	Histidine	14-23	aquaporin 2	Rattus norvegicus	139-143
26984496-5	2016	A recombinant histidine-tagged sPRR (sPRR-His) in the nanomolar range induced a remarkable increase in the abundance of renal aquaporin 2 (AQP2) protein in primary rat inner medullary collecting duct cells.	Histidine	42-45	small proline-rich protein 1A	Rattus norvegicus	31-35
26984496-5	2016	A recombinant histidine-tagged sPRR (sPRR-His) in the nanomolar range induced a remarkable increase in the abundance of renal aquaporin 2 (AQP2) protein in primary rat inner medullary collecting duct cells.	Histidine	42-45	small proline-rich protein 1A	Rattus norvegicus	37-41
29936386-4	2018	Compared with Taxol solution and HA-DOCA micelles, the cytotoxicity of PTX loaded in HA-DOCA-His micelles against drug-resistant tumor cells was improved significantly and possessed superior MDR-overcoming performance; this phenomenon is due to the increased intracellular PTX delivery by CD44 receptor-mediated endocytosis pathway and endosome-pH sensitivity-mediated PTX triggering release.	Histidine	93-96	CD44 antigen	Mus musculus	289-293
12526492-1	2000	The reaction of [Ru(bpy)2L(H2O)]2+ (bpy = 2,2"-bipyridine, L = imidazole, water) with reduced horse heart cytochrome c results in coordination of [RuII(bpy)2L] at the His 33 and His 26 sites.	Histidine	167-170	cytochrome c, somatic	Equus caballus	106-118
12526492-1	2000	The reaction of [Ru(bpy)2L(H2O)]2+ (bpy = 2,2"-bipyridine, L = imidazole, water) with reduced horse heart cytochrome c results in coordination of [RuII(bpy)2L] at the His 33 and His 26 sites.	Histidine	178-181	cytochrome c, somatic	Equus caballus	106-118
26984496-5	2016	A recombinant histidine-tagged sPRR (sPRR-His) in the nanomolar range induced a remarkable increase in the abundance of renal aquaporin 2 (AQP2) protein in primary rat inner medullary collecting duct cells.	Histidine	42-45	aquaporin 2	Rattus norvegicus	126-137
10748221-6	2000	Each bundle contains the sequence Cys-X(4)-Cys-X(8)-His-X(3)-Cys, and we show that a synthetic peptide comprising one zinc bundle from CH1 can fold in a zinc-dependent manner.	Histidine	52-55	SUN domain containing ossification factor	Homo sapiens	135-138
26984496-5	2016	A recombinant histidine-tagged sPRR (sPRR-His) in the nanomolar range induced a remarkable increase in the abundance of renal aquaporin 2 (AQP2) protein in primary rat inner medullary collecting duct cells.	Histidine	42-45	aquaporin 2	Rattus norvegicus	139-143
26927547-9	2016	Western blotting confirmed the expression of pcDNA3.1(+)-his-Oct4 transfected into HEK293T.	Histidine	57-60	POU class 5 homeobox 1	Homo sapiens	61-65
29773582-6	2018	In isolated endothelial cells, apelin caused an increase in 4,5-diaminofluorescein fluorescence that was abolished by nitro-l-arginine (NLA) and F13A (H-Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Ala-OH), an APJ receptor antagonist, consistent with increased nitric oxide (NO) production.	Histidine	177-180	apelin	Rattus norvegicus	31-37
26707622-11	2016	Immunoblotting indicated that maltose-binding protein (MBP)-OGT inhibited the binding of His-p120 to GST-ECD in a dose-dependent manner.	Histidine	89-92	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	60-63
10864417-0	2000	Regional distribution of histamine H3 receptor binding sites in rat brain following L-histidine loading--an autoradiography study.	Histidine	84-95	histamine receptor H3	Rattus norvegicus	25-46
26778000-0	2016	His-87 ligand in mitoNEET is crucial for the transfer of iron sulfur clusters from mitochondria to cytosolic aconitase.	Histidine	0-3	CDGSH iron sulfur domain 1	Homo sapiens	17-25
10715127-3	2000	Aligning the sequences of the mouse APA, APN, and other monozinc aminopeptidases led to the identification of a conserved histidine (His 450 in mouse APA).	Histidine	122-131	alanyl (membrane) aminopeptidase	Mus musculus	41-44
10715127-3	2000	Aligning the sequences of the mouse APA, APN, and other monozinc aminopeptidases led to the identification of a conserved histidine (His 450 in mouse APA).	Histidine	133-136	alanyl (membrane) aminopeptidase	Mus musculus	41-44
10651811-7	2000	Using these tools, it was demonstrated that the soluble His-tagged form of DnaJ protein exclusively binds the cytosolic isoform 1 of Hsp70.	Histidine	56-59	dnaJ protein homolog	Cucumis sativus	75-79
29659163-2	2018	In this study, the alpha-MSH-derived peptide NAP-NS1 (Nle-Asp-His-d-Phe-Arg-Trp-Gly-NH2 ) with and without linkers was conjugated with 5-(bis(pyridin-2-ylmethyl)amino)pentanoic acid (DPA-COOH) and labeled with [99m Tc]Tc-tricarbonyl by two methods.	Histidine	62-65	influenza virus NS1A binding protein	Homo sapiens	49-52
29661936-8	2018	Substitutions in the Cat domain affecting substrate specificity revealed that residues Phe-634, His-661, and Gly-671 in the S1-binding pocket of this domain are important for Ssy5 catalytic function.	Histidine	96-99	Ssy5p	Saccharomyces cerevisiae S288C	175-179
29844495-6	2018	Structure comparisons identify a TIRR histidine (H106) that is absent from the TIRR homolog Nudt16, but essential for 53BP1 Tudor binding.	Histidine	38-47	nudix hydrolase 16	Homo sapiens	92-98
26778000-4	2016	Our results confirm the observation that mitoNEET is important in transferring the iron sulfur clusters to the cytosolic aconitase in living cells and the His-87 ligand in mitoNEET plays important role in this process.	Histidine	155-158	CDGSH iron sulfur domain 1	Homo sapiens	41-49
29480716-6	2018	Furthermore, engineered histidine residues in UBA(2) strongly destabilize the iso-1-cytochrome c domain.	Histidine	24-33	eukaryotic translation initiation factor 1	Homo sapiens	78-83
26778000-4	2016	Our results confirm the observation that mitoNEET is important in transferring the iron sulfur clusters to the cytosolic aconitase in living cells and the His-87 ligand in mitoNEET plays important role in this process.	Histidine	155-158	CDGSH iron sulfur domain 1	Homo sapiens	172-180
26881185-2	2016	Due to the presence of the recognition unit GGH (Gly-Gly-His), the probe C-GGH can coordinate with Cu(2+) and consequently display ON-OFF type fluorescence response.	Histidine	57-60	gamma-glutamyl hydrolase	Homo sapiens	44-47
29078150-2	2018	In the human protein (hNgb), Cys46 and Cys55 form an intramolecular disulfide bond under oxidizing conditions, whose cleavage induces a helix-to-strand rearrangement of the CD loop that strengthens the bond between the heme iron and the distal histidine.	Histidine	244-253	neuroglobin	Homo sapiens	22-26
29187844-9	2017	speG also affects the expression of genes that have been rarely reported to correlate with polyamine metabolism in Salmonella, including those associated with the periplasmic nitrate reductase system, glucarate metabolism, the phosphotransferase system, cytochromes, and the succinate reductase complex in S. Typhimurium in the mid-log growth phase, as well as those in the ilv-leu and histidine biosynthesis operons of intracellular S. Typhimurium after invasion in Caco-2 cells.	Histidine	386-395	striated muscle enriched protein kinase	Homo sapiens	0-4
11087097-1	2000	We developed a rabbit polyclonal antiserum reactive against a recombinant 6x His-UL46 fusion protein expressed in Escherichia coli, and using this antiserum identified the UL46 gene product of herpes simplex virus type 2 (HSV-2) to be phosphoproteins with apparent molecular masses of 82-, 84-, and 86-kDa in infected Vero cells.	Histidine	77-80	modulates transactivating tegument protein VP16	Human alphaherpesvirus 2	81-85
11087097-1	2000	We developed a rabbit polyclonal antiserum reactive against a recombinant 6x His-UL46 fusion protein expressed in Escherichia coli, and using this antiserum identified the UL46 gene product of herpes simplex virus type 2 (HSV-2) to be phosphoproteins with apparent molecular masses of 82-, 84-, and 86-kDa in infected Vero cells.	Histidine	77-80	modulates transactivating tegument protein VP16	Human alphaherpesvirus 2	172-176
10574918-10	1999	We generated a carboxyl-terminal histidine-tagged recombinant antithrombin III to study the tag on another serpin.	Histidine	33-42	serpin family C member 1	Homo sapiens	62-78
26881185-2	2016	Due to the presence of the recognition unit GGH (Gly-Gly-His), the probe C-GGH can coordinate with Cu(2+) and consequently display ON-OFF type fluorescence response.	Histidine	57-60	gamma-glutamyl hydrolase	Homo sapiens	75-78
10567372-8	1999	The putative active site residues serine, aspartic acid, and histidine of QPP show an ordering of the catalytic triad similar to that seen in the post-proline cleaving exopeptidases prolylcarboxypeptidase and CD26/dipeptidyl peptidase IV.	Histidine	61-70	dipeptidyl peptidase 7	Homo sapiens	74-77
26606908-1	2015	Myoglobin (Mb) undergoes pronounced heme loss under denaturing conditions wherein the proximal histidine gets protonated.	Histidine	95-104	myoglobin	Homo sapiens	0-9
10567372-8	1999	The putative active site residues serine, aspartic acid, and histidine of QPP show an ordering of the catalytic triad similar to that seen in the post-proline cleaving exopeptidases prolylcarboxypeptidase and CD26/dipeptidyl peptidase IV.	Histidine	61-70	dipeptidyl peptidase 4	Homo sapiens	209-213
10567372-8	1999	The putative active site residues serine, aspartic acid, and histidine of QPP show an ordering of the catalytic triad similar to that seen in the post-proline cleaving exopeptidases prolylcarboxypeptidase and CD26/dipeptidyl peptidase IV.	Histidine	61-70	dipeptidyl peptidase 4	Homo sapiens	214-237
10567378-8	1999	A small fragment of p300 containing the carboxyl-terminal cysteine/histidine-rich domain, sufficient to interact with GATA-5, prevents transcriptional activation by GATA-5 as a dominant-negative mutant.	Histidine	67-76	GATA binding protein 5	Homo sapiens	118-124
10567378-8	1999	A small fragment of p300 containing the carboxyl-terminal cysteine/histidine-rich domain, sufficient to interact with GATA-5, prevents transcriptional activation by GATA-5 as a dominant-negative mutant.	Histidine	67-76	GATA binding protein 5	Homo sapiens	165-171
28833276-11	2017	Otherwise, Arg/His genotype (rs1229984) in ADH1B gene showed a protective effect against HD (aOR = 0.36; 95% CI: 0.14 to 0.90) and BD (aOR = 0.49; 95% CI: 0.21 to 0.95).	Histidine	15-18	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	43-48
29085768-7	2017	Due to these interactions, the large polycyclic moiety of the ligand would also block further interactions with Hsd6 (prototropic tautomer of His), Asp7, Ser8 and Gly9 that are integral to His6-His13-His14, Arg5-Asp7and Leu34-Gly38 beta-sheets, salt bridges in Glu22-Lys28 and turn conformation Phe19-Gly25.	Histidine	142-145	RNA, U1 small nuclear 4	Homo sapiens	112-116
26725560-4	2015	The synthetic DNA encoding the p19 was subcloned into a pGS21a vector along with a His-GST solubility/purification tag.	Histidine	83-86	interleukin 23 subunit alpha	Homo sapiens	31-34
28724772-2	2017	Two-hybrid and pulldown assays demonstrated that UL20, but no other HSV-1 gene-encoded proteins, binds specifically to GODZ (also known as DHHC3), a cellular Golgi apparatus-specific Asp-His-His-Cys (DHHC) zinc finger protein.	Histidine	187-190	envelope protein UL20	Human alphaherpesvirus 1	49-53
10563629-6	1999	RESULTS: Maternal relatives harbor a G-to-A missense mutation, heteroplasmic in some patients, at nucleotide position 11778 of the mitochondrial ND4 gene of complex I that converts a highly conserved arginine to a histidine.	Histidine	214-223	mitochondrially encoded NADH dehydrogenase 4	Homo sapiens	145-148
26531103-0	2015	Histidine residues are important for preserving the structure and heme binding to the C. elegans HRG-3 heme-trafficking protein.	Histidine	0-9	Heme Responsive Gene	Caenorhabditis elegans	97-102
10516162-6	1999	The following were ruled out as the underlying mechanisms: 1) voltage shift in channel activation, 2) pore blockade by protons, 3) protonation of histidines on the extracellular domain of HERG, 4) acceleration of recovery from C-type inactivation, and 5) interaction between an external H(+) binding site and the cytoplasmic NH(2)-terminal domain (a key determinant of HERG deactivation rate).	Histidine	146-156	potassium voltage-gated channel subfamily H member 2	Homo sapiens	188-192
28771333-1	2017	The reactions of picolinyl and 4-chloropicolinyl chlorides with methyl esters of S-methyl-l-cysteine, l- and d-methionine, and l-histidine afforded a series of functionalized carboxamides, which readily formed pincer-type complexes upon interaction with PdCl2(NCPh)2 in solution under mild conditions.	Histidine	127-138	phosducin like 2	Homo sapiens	254-266
28613440-2	2017	H3 O+ forms hydrogen bonds (H-bonds) with two histidine side-chains and a backbone carbonyl group in PcyA, whereas H3 O+ forms H-bonds with three acidic residues in XI.	Histidine	46-55	H3 clustered histone 15	Homo sapiens	0-4
10490616-4	1999	ERF2 encodes a 41-kDa protein with four predicted transmembrane (TM) segments and a motif consisting of the amino acids Asp-His-His-Cys (DHHC) within a cysteine-rich domain (CRD), called DHHC-CRD.	Histidine	124-127	palmitoyltransferase ERF2	Saccharomyces cerevisiae S288C	0-4
26551210-3	2015	Our protein interaction studies revealed that a millimolar concentration of sodium diclofenac is able to elute glutathione S-transferase (GST), cellulose binding protein (CBD), and maltose binding protein (MBP) but not histidine-tagged or PDZ-tagged proteins from their affinity resins.	Histidine	219-228	glutathione S-transferase kappa 1	Homo sapiens	138-141
26324451-4	2015	Thi5p synthesizes HMP-P from histidine and pyridoxal-5-phosphate and was reported to use a backbone histidine as the substrate, which would mean that it was a single-turnover enzyme.	Histidine	29-38	4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase	Saccharomyces cerevisiae S288C	0-5
10493588-1	1999	The extracellular portions of the chains that comprise the human type I interferon receptor, IFNAR1 and IFNAR2, have been expressed and purified as recombinant soluble His-tagged proteins, and their interactions with each other and with human interferon-beta-1a (IFN-beta-1a) were studied by gel filtration and by cross-linking.	Histidine	168-171	interferon alpha and beta receptor subunit 1	Homo sapiens	93-99
10446221-2	1999	Several missense IGF2R mutations have been identified in human cancers, including the following amino acid substitutions occurring in the extracytoplasmic domain of the receptor: Cys-1262 --&gt; Ser, Gln-1445 --&gt; His, Gly-1449 --&gt; Val, Gly-1464 --&gt; Glu, and Ile-1572 --&gt; Thr.	Histidine	216-219	insulin like growth factor 2 receptor	Homo sapiens	17-22
28483671-9	2017	Conversely, MMP-9 activity in the presence of 50muM acrolein was enhanced by 100muM histidine.	Histidine	84-93	matrix metallopeptidase 9	Homo sapiens	12-17
28483671-11	2017	These results suggest that activation of 92kDa MMP-9 by acrolein is involved in tissue damage in pSS patients and is regulated by cysteine and histidine, and slightly by lysine.	Histidine	143-152	matrix metallopeptidase 9	Homo sapiens	47-52
26324451-4	2015	Thi5p synthesizes HMP-P from histidine and pyridoxal-5-phosphate and was reported to use a backbone histidine as the substrate, which would mean that it was a single-turnover enzyme.	Histidine	100-109	4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase	Saccharomyces cerevisiae S288C	0-5
30108874-4	2017	In particular, the 3,4-dichlorobenzyl derivative 5b showed a comparable or superior activity against all the tested fungal strains to standard drugs, and formed a supramolecular complex with CYP51 via the hydrogen bond between the 4-nitrogen of the triazole nucleus and the histidine residue.	Histidine	274-283	lanosterol 14-alpha demethylase	Bos taurus	191-196
26205368-3	2015	The major differences between CTR1 and CTR2 are that CTR1 contains a HIS/MET-rich domain N-terminal of the METS that participate in the first two stacked rings that form the pore, and a longer C-terminal tail that includes a Cu binding HIS-CYS-HIS (HCH) motif right at the end.	Histidine	69-72	solute carrier family 31 member 1	Homo sapiens	30-34
28615107-3	2017	Following transformation into E.coli BL21, the soluble fusion protein His-FOXO3 was induced by IPTG and purified by Ni-NTA affinity chromatography.	Histidine	70-73	forkhead box O3	Mus musculus	74-79
10469826-4	1999	Further optimization can often be achieved by flipping the side chains of asparagine, histidine and glutamine around their chi2, chi2 and chi3 torsion angles, respectively, when this improves the local hydrogen bonding network.	Histidine	86-95	chitinase 1	Homo sapiens	138-142
26205368-3	2015	The major differences between CTR1 and CTR2 are that CTR1 contains a HIS/MET-rich domain N-terminal of the METS that participate in the first two stacked rings that form the pore, and a longer C-terminal tail that includes a Cu binding HIS-CYS-HIS (HCH) motif right at the end.	Histidine	69-72	solute carrier family 31 member 2	Homo sapiens	39-43
10393098-0	1999	Histidine-193 of rat glucosylceramide synthase resides in a UDP-glucose- and inhibitor (D-threo-1-phenyl-2-decanoylamino-3-morpholinopropan-1-ol)-binding region: a biochemical and mutational study.	Histidine	0-9	UDP-glucose ceramide glucosyltransferase	Rattus norvegicus	21-46
26205368-3	2015	The major differences between CTR1 and CTR2 are that CTR1 contains a HIS/MET-rich domain N-terminal of the METS that participate in the first two stacked rings that form the pore, and a longer C-terminal tail that includes a Cu binding HIS-CYS-HIS (HCH) motif right at the end.	Histidine	69-72	solute carrier family 31 member 1	Homo sapiens	53-57
10393098-5	1999	The histidine-modifying agent diethyl pyrocarbonate (DEPC) inhibited recombinant rat GCS expressed in bacteria; this inhibition was rapidly reversible by hydroxylamine and could be diminished by preincubation of GCS with UDP-Glc.	Histidine	4-13	UDP-glucose ceramide glucosyltransferase	Rattus norvegicus	85-88
28471462-6	2017	Copper is bound at the active site of MOR244-3 by cysteine and histidine, while cysteine, histidine and methionine are involved with OR2T11.	Histidine	90-99	olfactory receptor family 2 subfamily T member 11	Homo sapiens	133-139
10393098-5	1999	The histidine-modifying agent diethyl pyrocarbonate (DEPC) inhibited recombinant rat GCS expressed in bacteria; this inhibition was rapidly reversible by hydroxylamine and could be diminished by preincubation of GCS with UDP-Glc.	Histidine	4-13	UDP-glucose ceramide glucosyltransferase	Rattus norvegicus	212-215
26205368-3	2015	The major differences between CTR1 and CTR2 are that CTR1 contains a HIS/MET-rich domain N-terminal of the METS that participate in the first two stacked rings that form the pore, and a longer C-terminal tail that includes a Cu binding HIS-CYS-HIS (HCH) motif right at the end.	Histidine	236-239	solute carrier family 31 member 1	Homo sapiens	53-57
10393098-6	1999	These data suggest that DEPC acts on histidine residues within or near the UDP-Glc-binding site of GCS.	Histidine	37-46	UDP-glucose ceramide glucosyltransferase	Rattus norvegicus	99-102
26282237-5	2015	Current amplitudes were voltage dependent, strongly potentiated in oocytes preinjected with ascorbate (the canonical electron donor for cytochrome b561), and abolished by mutating a highly conserved His residue (H292L) predicted to coordinate the cytoplasmic heme b group.	Histidine	199-202	cytochrome b561	Homo sapiens	136-151
10393098-7	1999	Mutant proteins were expressed in which the eight histidine residues in GCS were individually replaced by other amino acids.	Histidine	50-59	UDP-glucose ceramide glucosyltransferase	Rattus norvegicus	72-75
28246171-6	2017	To resolve this discrepancy, we explored the role of the distal histidine residue in muting the reactivity of human neuroglobin toward H2S.	Histidine	64-73	neuroglobin	Homo sapiens	116-127
28270603-3	2017	In Arabidopsis thaliana accession Cvi-0, one of the two copies of a duplicated histidine biosynthesis gene, HISN6A, is mutated, making HISN6B essential.	Histidine	79-88	HISTIDINE BIOSYNTHESIS 6B	Arabidopsis thaliana	135-141
26337119-2	2015	In this study, a novel three-dimensional (3D) flower-like CdS is synthesized via a facile template-free hydrothermal process using Cd(NO3)2 4H2O and thiourea as precursors and L-Histidine as a chelating agent.	Histidine	176-187	CDP-diacylglycerol synthase 1	Homo sapiens	58-61
10329785-5	1999	Ferrochelatase from Drosophila melanogaster has been expressed in Escherichia coli with an amino-terminal six-histidine tag and purified to homogeneity.	Histidine	110-119	Ferrochelatase	Drosophila melanogaster	0-14
27241012-4	2017	Three Vssc mutations are known: kdr (L1014F), kdr-his (L1014H) and super-kdr (M918T + L1014F).	Histidine	50-53	sodium channel protein para-like	Musca domestica	6-10
27665193-4	2017	The SERS results for BN and its fragment demonstrated that (1) three amino acids from these peptides sequence; i.e., l-histidine, l-methionine, and l-tryptophan, are involved in the interaction with gold coated silicon wafer and (2) the strength of these interactions depends upon the aforementioned amino acids position in the peptide sequence.	Histidine	117-128	gastrin releasing peptide	Homo sapiens	21-23
26232532-4	2015	ZDHHC17 is a member of the DHHC (Asp-His-His-Cys)-containing family, a family of highly homologous proteins.	Histidine	37-40	zinc finger DHHC-type palmitoyltransferase 17	Rattus norvegicus	0-7
28039637-5	2017	Molecular docking studies of compound 3g with CAII showed this compound fits nicely in the active site of CAII and it interacts with the zinc ion ([Formula: see text]) along with three histidine residues in the active site.	Histidine	185-194	carbonic anhydrase 2	Homo sapiens	46-50
26226559-0	2015	Allosteric Breakage of the Hydrogen Bond within the Dual-Histidine Motif in the Active Site of Human Pin1 PPIase.	Histidine	57-66	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	101-105
27895119-8	2017	We also showed that replacing the phenylalanine 3.33 in CCR5 TM3 by the corresponding histidine of CCR2 converts J113863 from an antagonist for cell migration and a partial agonist in other assays to a full agonist in all assays.	Histidine	86-95	C-C motif chemokine receptor 5	Homo sapiens	56-60
10347122-7	1999	Western Blot with an HNE-Histidine antibody showed enhanced formation of HNE adducts with COX from ethanol-exposed rats, which was more pronounced in fetal than in adult livers.	Histidine	25-34	coproporphyrinogen oxidase	Rattus norvegicus	90-93
26226559-6	2015	Here, C113A and C113S Pin1 mutants were found to alter the protonation states of H59 according to the respective residue type replaced at C113, and the mutations resulted in disruption of the hydrogen bond within the dual-histidine motif.	Histidine	222-231	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	22-26
25794748-7	2015	The myoglobin in both quail species contained eight histidine residues instead of the nine present in chicken and turkey.	Histidine	52-61	myoglobin	Coturnix japonica	4-13
10229683-4	1999	Deoxyhypusine synthase was selectively retained by His.Tag-ec-eIF5A immobilized on a resin.	Histidine	51-54	eukaryotic translation initiation factor 5A	Homo sapiens	62-67
10318862-4	1999	Here, we report that substitution of glutamine for either of two putative active site histidines in the PP2A C subunit results in inactivation of PP2A and formation of stable complexes between PP2A and several cellular proteins.	Histidine	86-96	protein phosphatase 2 catalytic subunit alpha	Homo sapiens	104-110
10318862-4	1999	Here, we report that substitution of glutamine for either of two putative active site histidines in the PP2A C subunit results in inactivation of PP2A and formation of stable complexes between PP2A and several cellular proteins.	Histidine	86-96	protein phosphatase 2 phosphatase activator	Homo sapiens	104-108
10318862-4	1999	Here, we report that substitution of glutamine for either of two putative active site histidines in the PP2A C subunit results in inactivation of PP2A and formation of stable complexes between PP2A and several cellular proteins.	Histidine	86-96	protein phosphatase 2 phosphatase activator	Homo sapiens	146-150
10402203-0	1999	Identification and mechanism of action of two histidine residues underlying high-affinity Zn2+ inhibition of the NMDA receptor.	Histidine	46-55	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	113-126
28250719-1	2017	Two new somatostatin analogs with a characteristic part of the sequence -c(Cys-Phe-Trp-Lys-Thr-Cys)- and with two histidine and two aspartic acid moieties in their structures were synthesized and analyzed in terms of their coordination abilities with copper (II) ions.	Histidine	114-123	somatostatin	Homo sapiens	8-20
27934216-5	2016	Here, we combine various biophysical methods to explore the interaction between this Ctr1 segment and metallochaperone Atox1 and clearly demonstrate that the Ctr1 intracellular loop (1) can coordinate Cu(I) via interactions with the side chains of one histidine and two methionine residues and (2) closely interacts with the Atox1 metallochaperone.	Histidine	252-261	antioxidant 1 copper chaperone	Homo sapiens	119-124
27934216-5	2016	Here, we combine various biophysical methods to explore the interaction between this Ctr1 segment and metallochaperone Atox1 and clearly demonstrate that the Ctr1 intracellular loop (1) can coordinate Cu(I) via interactions with the side chains of one histidine and two methionine residues and (2) closely interacts with the Atox1 metallochaperone.	Histidine	252-261	antioxidant 1 copper chaperone	Homo sapiens	325-330
26120805-1	2015	By employing DNAzyme as a recognition group and amplifier, and DNA-stabilized silver nanoclusters (DNA/AgNCs) as signal reporters, we reported for the first time a label-free catalytic and molecular beacon as an amplified biosensing platform for highly selective detection of cofactors such as Pb(2+) and L-histidine.	Histidine	305-316	ubiquitin like 5	Homo sapiens	199-205
27613409-4	2016	Using wild-type as well as Gcn2 knockout and unphosphorylatable eIF2alpha mutant MEFs, we characterized a novel GCN2/eIF2alpha phosphorylation-independent, but ATF4-dependent, pathway that upregulates the expression of CARE-containing genes in MEFs lacking GCN2 or phosphorylatable eIF2alpha when these cells are exposed to methionine-deficient, and to a lesser extent arginine- or histidine-deficient, medium.	Histidine	382-391	eukaryotic translation initiation factor 2 alpha kinase 4	Homo sapiens	112-116
27613409-4	2016	Using wild-type as well as Gcn2 knockout and unphosphorylatable eIF2alpha mutant MEFs, we characterized a novel GCN2/eIF2alpha phosphorylation-independent, but ATF4-dependent, pathway that upregulates the expression of CARE-containing genes in MEFs lacking GCN2 or phosphorylatable eIF2alpha when these cells are exposed to methionine-deficient, and to a lesser extent arginine- or histidine-deficient, medium.	Histidine	382-391	eukaryotic translation initiation factor 2A	Homo sapiens	117-126
27613409-4	2016	Using wild-type as well as Gcn2 knockout and unphosphorylatable eIF2alpha mutant MEFs, we characterized a novel GCN2/eIF2alpha phosphorylation-independent, but ATF4-dependent, pathway that upregulates the expression of CARE-containing genes in MEFs lacking GCN2 or phosphorylatable eIF2alpha when these cells are exposed to methionine-deficient, and to a lesser extent arginine- or histidine-deficient, medium.	Histidine	382-391	eukaryotic translation initiation factor 2A	Homo sapiens	117-126
10090732-5	1999	When the T state interface is weakened by Asp --&gt; Asn substitution at a quaternary H-bond (HbK), the Fe-His bond is relaxed and becomes responsive to allosteric effectors.	Histidine	107-110	hemoglobin subunit mu	Homo sapiens	94-97
10205296-3	1999	The bond between Fe and proximal His-F8 allows additional integration of the structures of the heme cavity and the myoglobin molecule as a whole, providing its functional activity and highly cooperative conformational transitions.	Histidine	34-37	myoglobin	Homo sapiens	116-125
26148000-2	2015	We have already shown that myosin in low ionic strength solution containing L-histidine forms a transparent gel after heating.	Histidine	76-87	myosin heavy chain 14	Homo sapiens	27-33
10191072-4	1999	However, most cyclostome braconids have either a "DK" or a "DHK" arrangement (where "H" refers to the tRNA gene for Histidine).	Histidine	116-125	transfer RNA:Lysine-TTT 2-2	Drosophila melanogaster	102-106
27818108-2	2016	In this study the role of His 72 in TmPurL, a glutamine amidotransferase (GAT) enzyme, is investigated.	Histidine	26-29	guanine monophosphate synthase	Homo sapiens	46-72
27818108-2	2016	In this study the role of His 72 in TmPurL, a glutamine amidotransferase (GAT) enzyme, is investigated.	Histidine	26-29	guanine monophosphate synthase	Homo sapiens	74-77
26148000-4	2015	The hydrophobicity of myosin and heavy meromyosin (HMM) in low ionic strength solution containing L-histidine was lower than in high ionic strength solution.	Histidine	98-109	myosin heavy chain 14	Homo sapiens	22-28
26148000-5	2015	The SH contents of myosin and HMM in low ionic strength solution containing l-histidine did not change during the heating process, whereas in high ionic strength solution they decreased slightly.	Histidine	76-87	myosin heavy chain 14	Homo sapiens	19-25
27801576-2	2016	The high-spin Fe(II) complexes feature the facially coordinating tris(4,5-diphenyl-1-methylimidazol-2-yl)phosphine (Ph2TIP) ligand that replicates the three histidine (3His) triad of the TDO active sites.	Histidine	157-166	tryptophan 2,3-dioxygenase	Homo sapiens	187-190
27374989-8	2016	We suggest that Dm eIF4E-3 and Dm eIF4E-5 bind the second nucleoside of the cap in an unusual manner via stacking interactions with a histidine or a phenylalanine residue, respectively.	Histidine	134-143	eukaryotic translation initiation factor 4E5	Drosophila melanogaster	34-41
10499107-5	1999	The Fe-C and C-O vibrational frequencies of CO-myoglobin have also been studied and the results indicate that CO forms hydrogen bonds to either the distal histidine residue or a water molecule during normal conditions.	Histidine	155-164	myoglobin	Homo sapiens	47-56
25808120-11	2015	The Trp-His peptide was not visualized in the presence of Gly-Sar, which is a model peptide that is transported via the intestinal proton-coupled peptide transporter 1 (PepT1) transporter.	Histidine	8-11	solute carrier family 15 member 1	Rattus norvegicus	169-174
9973256-3	1999	We show that CREB binding protein (CBP), through two cysteine-histidine rich domains (C/H1 and C/H3), specifically and constitutively interacts with Pit-1 in pituitary cells.	Histidine	62-71	SUN domain containing ossification factor	Homo sapiens	86-99
10027556-4	1999	As a result of screening, we identified two proteins (192 and 180 kDa), which specifically bound to His-dPER/PAS in rat brain extracts.	Histidine	100-103	period	Drosophila melanogaster	104-108
27382069-7	2016	We also identify an 11 Histidine repeat and the homeodomain of HOXA1 to be required both for RBCK1 and TRAF2 interaction and NF-kappaB stimulation.	Histidine	23-32	TNF receptor associated factor 2	Homo sapiens	103-108
26095028-1	2015	Imidazoleglycerol-phosphate dehydratase (IGPD) catalyzes the Mn(II)-dependent dehydration of imidazoleglycerol phosphate (IGP) to 3-(1H-imidazol-4-yl)-2-oxopropyl dihydrogen phosphate during biosynthesis of histidine.	Histidine	207-216	imidazoleglycerol-phosphate dehydratase	Arabidopsis thaliana	0-39
27590064-3	2016	Based on the sequence homology, Exo70A1 is divided into four subdomains: leucine zipper (Leu(128)-Leu(149)), hypervariable region (Ser(172)-Leu(197)), SUMO modification motif (Glu(260)-Ile(275)), and pfamExo70 domain (His(271)-Phe(627)).	Histidine	218-221	exocyst complex component EXO70A1	Brassica oleracea	32-39
10447101-2	1999	Replacement of His with Ala resulted in [Ala6]-MT-II with affinity and agonist potency at human MC3, MC4, and MC5 receptors similar to MT-II.	Histidine	15-18	metallothionein 2A	Homo sapiens	47-52
26273845-1	2015	This work outlines the synthesis of a non-emissive, cyclometalated Ir(III) complex, Ir(ppy)2(H2O)2(+) (Ir1), which elicits a rapid, long-lived phosphorescent signal when coordinated to a histidine-containing protein immobilized on the surface of a magnetic particle.	Histidine	187-196	nischarin	Homo sapiens	103-106
9832609-5	1998	However, if the cDNA was fused with the histidine-tag sequence at the N-terminus, MTFmt could be expressed in Escherichia coli.	Histidine	40-49	mitochondrial methionyl-tRNA formyltransferase	Homo sapiens	82-87
9832609-9	1998	The purified recombinant MTFmt with the histidine-tag showed almost identical kinetic parameters to those of native MTFmt.	Histidine	40-49	mitochondrial methionyl-tRNA formyltransferase	Homo sapiens	25-30
27334921-4	2016	The LECT2 structure adopts a conserved Zn(II) coordination configuration but lacks a proposed catalytic histidine residue, and its potential substrate-binding groove is blocked in the vicinity of the Zn(II)-binding site by an additional intrachain loop at the N terminus.	Histidine	104-113	leukocyte cell derived chemotaxin 2	Homo sapiens	4-9
25977460-14	2015	(111)In-JVZ007-c-myc-his and (111)In-JVZ007-cys internalized in LNCaP cells and bound to PSMA-expressing PDXs and, importantly, not to PSMA-negative PDXs and human kidneys.	Histidine	21-24	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	15-20
27273166-5	2016	The target enzyme was immobilised on the silica capillary via Schiff base formation (to give LmNDKb-ICER-Schiff) or affinity attachment (to give LmNDKb-ICER-His).	Histidine	157-160	cAMP responsive element modulator	Homo sapiens	152-156
9853614-2	1998	Human formyl peptide receptor like-1 (FPRL-1) receptor, originally identified as an orphan G protein-coupled receptor related to the formyl peptide receptor (FPR1), was expressed in Saccharomyces cells designed to couple receptor activation to histidine prototrophy.	Histidine	244-253	formyl peptide receptor 2	Homo sapiens	6-36
9853614-2	1998	Human formyl peptide receptor like-1 (FPRL-1) receptor, originally identified as an orphan G protein-coupled receptor related to the formyl peptide receptor (FPR1), was expressed in Saccharomyces cells designed to couple receptor activation to histidine prototrophy.	Histidine	244-253	formyl peptide receptor 2	Homo sapiens	38-44
25977460-17	2015	The replacement of the c-myc-his tag by the cysteine contributed to a further reduction of renal uptake without loss of targeting.	Histidine	29-32	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	23-28
9806842-2	1998	The product, which consists of 785 amino acids with a deduced molecular mass of 88.2 kDa, possesses His and Cys domains that are highly conserved in all members of the ubiquitin-specific processing (UBP) family of proteases.	Histidine	100-103	ubiquitin specific peptidase 1	Homo sapiens	168-197
9806842-2	1998	The product, which consists of 785 amino acids with a deduced molecular mass of 88.2 kDa, possesses His and Cys domains that are highly conserved in all members of the ubiquitin-specific processing (UBP) family of proteases.	Histidine	100-103	ubiquitin specific peptidase 1	Homo sapiens	199-202
27323149-5	2016	There was a significant association between the XPG gene Asp1104His polymorphism and lung cancer (His/His vs Asp/Asp: OR = 1.24, 95%CI = 1.04-1.48; Asp/His vs Asp/Asp: OR = 1.17, 95%CI = 1.03-1.34; the dominant model: OR = 1.18, 95%CI = 1.04-1.33; the recessive model: OR = 1.10, 95%CI = 0.94-1.28).	Histidine	64-67	ERCC excision repair 5, endonuclease	Homo sapiens	48-51
27323149-5	2016	There was a significant association between the XPG gene Asp1104His polymorphism and lung cancer (His/His vs Asp/Asp: OR = 1.24, 95%CI = 1.04-1.48; Asp/His vs Asp/Asp: OR = 1.17, 95%CI = 1.03-1.34; the dominant model: OR = 1.18, 95%CI = 1.04-1.33; the recessive model: OR = 1.10, 95%CI = 0.94-1.28).	Histidine	98-101	ERCC excision repair 5, endonuclease	Homo sapiens	48-51
25766873-0	2015	The role of His-83 of yeast apurinic/apyrimidinic endonuclease Apn1 in catalytic incision of abasic sites in DNA.	Histidine	12-15	DNA-(apurinic or apyrimidinic site) lyase APN1	Saccharomyces cerevisiae S288C	63-67
27250920-0	2016	Role of Histidine 547 of Human Dopamine Transporter in Molecular Interaction with HIV-1 Tat and Dopamine Uptake.	Histidine	8-17	solute carrier family 6 member 3	Homo sapiens	31-51
9972245-0	1998	Mutational analysis of the histidine-containing phosphotransfer (HPt) signaling domain of the ArcB sensor in Escherichia coli.	Histidine	27-36	hypothetical protein	Escherichia coli	94-98
25766873-3	2015	Based on its high amino acid homology to Escherichia coli Endo IV, His-83 is believed to coordinate one of three Zn2+ ions in Apn1"s active site similar to His-69 in Endo IV.	Histidine	67-70	DNA-(apurinic or apyrimidinic site) lyase APN1	Saccharomyces cerevisiae S288C	126-130
25766873-3	2015	Based on its high amino acid homology to Escherichia coli Endo IV, His-83 is believed to coordinate one of three Zn2+ ions in Apn1"s active site similar to His-69 in Endo IV.	Histidine	156-159	DNA-(apurinic or apyrimidinic site) lyase APN1	Saccharomyces cerevisiae S288C	126-130
27136534-4	2016	Absorption spectra of AHbs distal histidine mutants showed that AHb1 mutant (H69L) is a stable pentacoordinate high-spin species in both ferrous and ferric states, whereas heme iron in AHb2 mutant (H66L) is hexacoordinated low-spin with Lys69 as the sixth ligand.	Histidine	34-43	hemoglobin 1	Arabidopsis thaliana	64-68
25980580-2	2015	To test the hypothesis that IDH1 mutations could generate metabolic vulnerabilities for therapeutic intervention, we utilized an MCF10A cell line engineered with an arginine-to-histidine conversion at position 132 (R132H) in the catalytic site of IDH1, which equips the enzyme with a neomorphic alpha-ketoglutarate to 2HG reducing activity in an otherwise isogenic background.	Histidine	177-186	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	28-32
26930370-10	2016	Lactate level was reduced in serum of LGMD-2B patients and histidine was reduced in serum of patients with FSHD as compared to normal subjects.	Histidine	59-68	FSHMD1A	Homo sapiens	107-111
9768847-4	1998	The bound Cd2+ ions form a bridge between the introduced cysteine in one channel subunit and a native histidine in another subunit, and the bridge traps the gate in the open state.	Histidine	102-111	CD2 molecule	Homo sapiens	10-13
9724720-6	1998	The inverse combination (C-1/G73) leads to the worst histidine acceptors with charging efficiencies reduced by 2-3 orders of magnitude.	Histidine	53-62	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	25-32
26229983-5	2015	Comparison of these two structures argues in favor of a direct role of the conserved histidine in the switch II loop of EF-G in GTPase activation, and explains why GTP hydrolysis cannot proceed with EF-G bound to the unrotated form of the ribosome.	Histidine	85-94	G elongation factor mitochondrial 1	Homo sapiens	120-124
9724722-3	1998	The human endostatin zinc site is formed by three histidines at the N terminus, residues 1, 3, and, 11, and an aspartic acid at residue 76.	Histidine	50-60	collagen type XVIII alpha 1 chain	Homo sapiens	10-20
9680483-8	1998	A buried salt bridge involving a histidine on the Max LZ and two glutamate residues on the c-Myc LZ is observed at the interface of the heterodimeric LZ.	Histidine	33-42	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	91-96
27094155-1	2016	The present study was undertaken to investigate the possible protective effect of L-carnosine (CAR), an endogenous dipeptide of alanine and histidine, on carbon tetrachloride (CCl4)-induced hepatic injury.	Histidine	140-149	nuclear receptor subfamily 1, group I, member 3	Rattus norvegicus	82-99
25849630-7	2015	Sequence alignment of PhuR with all known Gram-negative OM heme receptors revealed a lack of a conserved His within the FRAP loop but two Tyr residues at positions 519 and 529.	Histidine	105-108	heme/hemoglobin uptake outer membrane receptor PhuR	Pseudomonas aeruginosa PAO1	22-26
26692147-6	2016	Moreover, the presence of the Gln/Gln, Arg/His, and His/His genotypes of XRCC1 was significantly more likely to have bone erosion and extra-articular features in RA patients.	Histidine	43-46	X-ray repair cross complementing 1	Homo sapiens	73-78
9704652-3	1998	The patient"s serum was used to clone a dek complementary DNA, which was expressed as a histidine-tagged fusion protein in Escherichia coli.	Histidine	88-97	DEK proto-oncogene	Homo sapiens	40-43
25849630-8	2015	Site-directed mutagenesis and spectroscopic characterization confirmed Tyr-519 and the N-terminal plug His-124 provide the heme ligands in PhuR.	Histidine	103-106	heme/hemoglobin uptake outer membrane receptor PhuR	Pseudomonas aeruginosa PAO1	139-143
25919709-0	2014	Involvement of Histidine Residue His382 in pH Regulation of MCT4 Activity.	Histidine	15-24	solute carrier family 16 member 3 S homeolog	Xenopus laevis	60-64
9777417-9	1998	MASP of the second group has structural features which are distinct from those of the first group: an absence of a histidine loop, an active-serine encoded by AGY, and an alanine or valine as the amino acid residue at the -3 position from the active-serine.	Histidine	115-124	MBL associated serine protease 1	Homo sapiens	0-4
9671411-6	1998	The PML aminoterminal portion retained within the PML/RARalpha protein contains the RING finger, two newly defined cystein/histidine-rich motifs called B-boxes (B1 and B2) and a coiled-coil region.	Histidine	123-132	PML nuclear body scaffold	Homo sapiens	4-7
24892632-2	2016	The multifunctional oHA conjugates, oHA-histidine-MGK (oHM) carried the pH-sensitive MGK as hydrophobic moieties and oHA as the target of CD44 receptor.	Histidine	40-49	CD44 molecule (Indian blood group)	Homo sapiens	138-142
25919709-3	2014	We investigated the critical histidine residue involved in pH regulation of MCT4 function.	Histidine	29-38	solute carrier family 16 member 3 S homeolog	Xenopus laevis	76-80
26641249-3	2015	We found that two small paralogous nickel-binding proteins with high content in Histidine (Hpn and Hpn-2) play a central role in maintaining non-toxic intracellular nickel content and in controlling its intracellular trafficking.	Histidine	80-89	hepsin	Mus musculus	91-94
9671411-6	1998	The PML aminoterminal portion retained within the PML/RARalpha protein contains the RING finger, two newly defined cystein/histidine-rich motifs called B-boxes (B1 and B2) and a coiled-coil region.	Histidine	123-132	PML nuclear body scaffold	Homo sapiens	50-53
9671411-6	1998	The PML aminoterminal portion retained within the PML/RARalpha protein contains the RING finger, two newly defined cystein/histidine-rich motifs called B-boxes (B1 and B2) and a coiled-coil region.	Histidine	123-132	retinoic acid receptor alpha	Homo sapiens	54-62
26641249-3	2015	We found that two small paralogous nickel-binding proteins with high content in Histidine (Hpn and Hpn-2) play a central role in maintaining non-toxic intracellular nickel content and in controlling its intracellular trafficking.	Histidine	80-89	hepsin	Mus musculus	99-102
25919709-6	2014	The histidine modifier DEPC (diethyl pyrocarbonate) reduced MCT4 activity but did not completely inactivate MCT4.	Histidine	4-13	solute carrier family 16 member 3 S homeolog	Xenopus laevis	60-64
25919709-11	2014	Our findings demonstrate that the histidine residue His382 in the extracellular loop of the transporter is essential for pH regulation of MCT4-mediated substrate transport activity.	Histidine	34-43	solute carrier family 16 member 3 S homeolog	Xenopus laevis	138-142
9601054-6	1998	It was found that the mutation of Lys83, Arg347 and Arg358 produced proteins that were deficient in their responsiveness to cytochrome b5, and the effect was most pronounced for the two arginine mutants (Arg347--&gt;His and Arg358--&gt;Gln) which have been found in male patients suffering from genital ambiguity.	Histidine	216-219	cytochrome b5 type A	Homo sapiens	124-137
25881887-8	2015	Further analyses of affinity-purified His-tag LAPTM4B overexpressed in HEK cells showed that the 31.5 kDa protein represented the ubiquinated isoform of the 26.3 kDa native protein.	Histidine	38-41	lysosomal-associated transmembrane protein 4B	Bos taurus	46-53
9528793-5	1998	The transactivation function of Ets-1 correlated with its ability to bind an N-terminal cysteine- and histidine-rich region spanning CBP residues 313 to 452.	Histidine	102-111	ETS proto-oncogene 1, transcription factor	Homo sapiens	32-37
9528793-6	1998	Ets-1 also bound a second cysteine- and histidine-rich region of CBP, between residues 1449 and 1892.	Histidine	40-49	ETS proto-oncogene 1, transcription factor	Homo sapiens	0-5
9488685-3	1998	In this study, we examined the interaction of the dipeptides and beta-lactam antibiotics with the histidine residue of rat PEPT1 and PEPT2 transfected into the renal epithelial cell line LLC-PK1.	Histidine	98-107	solute carrier family 15 member 1	Rattus norvegicus	123-128
26311893-4	2015	In contrast, uncleaved, histidine-tagged Foldon (Fd) domain-containing gp140 proteins (gp140UNC-Fd-His), based on the same env genes, very rarely form native-like trimers, a finding that is consistent with their antigenic and biophysical properties and glycan composition.	Histidine	24-33	endogenous retrovirus group K member 20	Homo sapiens	123-126
26388194-6	2015	This mutation causes an amino exchange Gln&gt;His at Position 806 located in the calf-2 domain of GPIIb.	Histidine	46-49	integrin subunit alpha 2b	Homo sapiens	98-103
25616666-7	2015	However, the unique His-Tyr-ligated PhuR plays a major role in the acquisition of heme.	Histidine	20-23	heme/hemoglobin uptake outer membrane receptor PhuR	Pseudomonas aeruginosa PAO1	36-40
26409900-3	2015	HPRG has been reported to bind various ligands and to modulate angiogenesis via the histidine residues of the HPRR.	Histidine	84-93	histidine rich glycoprotein	Homo sapiens	0-4
9488685-8	1998	These findings suggest that the alpha-amino group of beta-lactam antibiotics interacts with the histidine residue of PEPT1 and PEPT2 and may be involved in the mechanism of substrate recognition by the peptide transporters.	Histidine	96-105	solute carrier family 15 member 1	Rattus norvegicus	117-122
25306337-0	2015	The solubility and conformational characteristics of porcine myosin as affected by the presence of L-lysine and L-histidine.	Histidine	112-123	myosin heavy chain 14	Homo sapiens	61-67
9473505-4	1998	A mutant strain of S. cerevisiae that is both a histidine auxotroph and a hip1 deletion mutant is unable to grow on low histidine media.	Histidine	120-129	histidine permease	Saccharomyces cerevisiae S288C	74-78
26593415-3	2015	We synthesized an N-palmitoylated peptide Palm-Val-[Lys-Asn-Lys-Asn-Leu-His-Ser-Pro-(Nle)-Tyr-Phe-Phe71-82]-amide-Palm-Val-(71-82) structurally corresponding to cytoplasmic loop 1 of melanocortin 4 receptor (M4R).	Histidine	72-75	melanocortin 4 receptor	Rattus norvegicus	183-206
26593415-3	2015	We synthesized an N-palmitoylated peptide Palm-Val-[Lys-Asn-Lys-Asn-Leu-His-Ser-Pro-(Nle)-Tyr-Phe-Phe71-82]-amide-Palm-Val-(71-82) structurally corresponding to cytoplasmic loop 1 of melanocortin 4 receptor (M4R).	Histidine	72-75	melanocortin 4 receptor	Rattus norvegicus	208-211
9473505-9	1998	In a hip1 tat1 double mutant, the level of histidine required for growth increased eight-fold in comparison to the hip1 single mutant.	Histidine	43-52	histidine permease	Saccharomyces cerevisiae S288C	5-9
25306337-2	2015	The solubility of myosin was increased in the presence of L-his and/or L-lys in all ionic strength solutions used.	Histidine	58-63	myosin heavy chain 14	Homo sapiens	18-24
9473505-9	1998	In a hip1 tat1 double mutant, the level of histidine required for growth increased eight-fold in comparison to the hip1 single mutant.	Histidine	43-52	histidine permease	Saccharomyces cerevisiae S288C	115-119
25516571-0	2015	Characterization of the histidine-rich loop of Arabidopsis vacuolar membrane zinc transporter AtMTP1 as a sensor of zinc level in the cytosol.	Histidine	24-33	zinc transporter	Arabidopsis thaliana	94-100
9480763-2	1998	A variant of yeast iso-1-cytochrome c designated TM, which lacks all histidine residues except His18, still shows evidence of denatured state heme ligation in the pH range between 5 and 6 where normally only histidine ligation is expected.	Histidine	69-78	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	19-24
9480763-2	1998	A variant of yeast iso-1-cytochrome c designated TM, which lacks all histidine residues except His18, still shows evidence of denatured state heme ligation in the pH range between 5 and 6 where normally only histidine ligation is expected.	Histidine	208-217	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	19-24
9480763-5	1998	The N-terminal amino group thus competes with histidine for misligation of iso-1-cytochrome c under denaturing conditions.	Histidine	46-55	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	75-80
26253506-6	2015	CONCLUSIONS: Through whole exome sequencing and expanded cohort screening, we identified a novel genetic substrate p.Arg518Cys/His-CACNA1C, in patients with a complex phenotype including LQTS, HCM, and congenital heart defects annotated as cardiac-only Timothy syndrome.	Histidine	127-130	calcium voltage-gated channel subunit alpha1 C	Homo sapiens	131-138
25516571-1	2015	The vacuolar Zn(2+)/H(+) antiporter of Arabidopsis thaliana, AtMTP1, has a long cytosolic histidine-rich loop.	Histidine	90-99	zinc transporter	Arabidopsis thaliana	61-67
25516571-2	2015	A mutated AtMTP1 in which the first half of the loop (His-half) was deleted exhibited a 11-fold higher transport velocity in yeast cells.	Histidine	54-57	zinc transporter	Arabidopsis thaliana	10-16
9447964-2	1998	CPEB, which is conserved from mammals to invertebrates, is composed of three regions: an amino-terminal portion with no obvious functional motif, two RNA recognition motifs (RRMs), and a cysteine-histidine region that is reminiscent of a zinc finger.	Histidine	196-205	cytoplasmic polyadenylation element binding protein 1 L homeolog	Xenopus laevis	0-4
25516571-5	2015	The His-half AtMTP1 transported cobalt in a heterologous expression assay in yeast, but the cumulative amount of cobalt in 35S-His-half plants was not increased.	Histidine	4-7	zinc transporter	Arabidopsis thaliana	13-19
25155647-2	2015	Herein, a straightforward method is demonstrated for efficient encapsidation of magnetic nanoparticles into the engineered virus-like particle (VLP) through the affinity of histidine tags for the nickel- nitrilotriacetic acid (NTA) chelate.	Histidine	173-182	VHL like	Homo sapiens	144-147
9489669-0	1998	An Escherichia coli protein that exhibits phosphohistidine phosphatase activity towards the HPt domain of the ArcB sensor involved in the multistep His-Asp phosphorelay.	Histidine	148-151	hypothetical protein	Escherichia coli	110-114
9489669-1	1998	The Escherichia coli sensory kinase, ArcB, possesses a histidine-containing phosphotransfer (HPt) domain, which is implicated in the His-Asp multistep phosphorelay.	Histidine	55-64	hypothetical protein	Escherichia coli	37-41
9489669-1	1998	The Escherichia coli sensory kinase, ArcB, possesses a histidine-containing phosphotransfer (HPt) domain, which is implicated in the His-Asp multistep phosphorelay.	Histidine	133-136	hypothetical protein	Escherichia coli	37-41
26216015-1	2015	Thyrotropin-releasing hormone (TRH)-like peptides were synthesized by replacing critical histidine and pGlu residues in the native peptide.	Histidine	89-98	thyrotropin releasing hormone	Mus musculus	0-29
26249842-5	2015	Our simulations have also identified crucial aromatic-aromatic interactions which stabilize the orientation of the catalytic histidine for inline nucleophilic attack during AMPylation, thus providing a structural basis for the evolutionary conservation of these aromatic residue pairs in Fic domains.	Histidine	125-134	C-C motif chemokine ligand 7	Homo sapiens	288-291
25643626-7	2015	Serine, proline, or histidine-mediated lifespan extension was greatly inhibited in eat-2 worms, a model of dietary restriction, in daf-16/FOXO, sir-2.1, rsks-1 (ribosomal S6 kinase), gcn-2, and aak-2 (AMPK) longevity pathway mutants, and in bec-1 autophagy-defective knockdown worms.	Histidine	20-29	Neuronal acetylcholine receptor subunit eat-2	Caenorhabditis elegans	83-88
9425114-8	1998	No sequence similarity to the human fragile histidine triad protein, as found in the Ap4A hydrolase from Schizosaccharomyces pombe, was detected in the Ap4A hydrolase from lupin.	Histidine	44-53	nudix hydrolase 2	Sus scrofa	85-99
26088577-8	2015	The NDPKB-induced increase in ISK4 was prevented by protein histidine phosphatase 1, but not an inactive protein histidine phosphatase 1 mutant indicating that ISK4 is regulated via histidine phosphorylation in proliferating VSMC; moreover, genetic NDPKB ablation reduced ISK4 by 50% suggesting a constitutive activation of ISK4 in proliferating VSMC.	Histidine	60-69	NME/NM23 nucleoside diphosphate kinase 2	Mus musculus	4-9
25643626-7	2015	Serine, proline, or histidine-mediated lifespan extension was greatly inhibited in eat-2 worms, a model of dietary restriction, in daf-16/FOXO, sir-2.1, rsks-1 (ribosomal S6 kinase), gcn-2, and aak-2 (AMPK) longevity pathway mutants, and in bec-1 autophagy-defective knockdown worms.	Histidine	20-29	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	131-137
25130193-6	2015	We found that polymorphic haplotypes in the MDA-5 gene IFIH1 encoding histidine at position 843 and threonine at position 946 strongly correlate with the resolution of HCV infection (odds ratio [OR]: 16.23; 95% confidence interval [CI]: 3.67-71.87; P = 1.1 x 10(-6) ).	Histidine	70-79	interferon induced with helicase C domain 1	Homo sapiens	44-49
26191403-1	2015	TRH-like peptides were synthesized in which the critical N-terminus residue L-pGlu was replaced with various heteroaromatic rings, and the central residue histidine with 1-alkyl-L-histidines.	Histidine	155-164	thyrotropin releasing hormone	Mus musculus	0-3
25130193-7	2015	Overexpression of MDA-5 genetic variants in HEK 293 cells and in a tissue culture model of HCV infection revealed that the histidine 843/threonine 946 variant leads to increased baseline and ligand-induced expression of interferon-induced genes and confers an increased ability to suppress HCV replication.	Histidine	123-132	interferon induced with helicase C domain 1	Homo sapiens	18-23
9782258-5	1998	We used a baculovirus expression system to produce soluble recombinant murine Bgp receptors in which the transmembrane and cytoplasmic domains have been replaced with a six-histidine tag.	Histidine	173-182	carcinoembryonic antigen-related cell adhesion molecule 1	Mus musculus	78-81
25935222-5	2015	For the recognition of each amino acid (here, serine, proline, glycine, asparagine, leucine, and histidine), the corresponding aminoacyl-tRNA synthetase (aaRS) was employed, and multiple enzymatic reactions were combined with a luminol chemiluminescence reaction.	Histidine	97-106	alanyl-tRNA synthetase 1	Homo sapiens	127-152
25060725-3	2015	The CMD-layer was found to be advantageous in terms of not only immobilization of histidine-tagged recombinant protein A-mediated an antibody against myoglobin (anti-Myo) but also prevention of non-specific binding of myoglobin.	Histidine	82-91	myoglobin	Homo sapiens	150-159
25935222-5	2015	For the recognition of each amino acid (here, serine, proline, glycine, asparagine, leucine, and histidine), the corresponding aminoacyl-tRNA synthetase (aaRS) was employed, and multiple enzymatic reactions were combined with a luminol chemiluminescence reaction.	Histidine	97-106	alanyl-tRNA synthetase 1	Homo sapiens	154-158
9396728-4	1997	The results obtained indicate that His-13 of P21 co-ordinates to the sixth co-ordination position of the haem iron, thus leading to the formation of a complex characterized by an equilibrium between an "open" and a "closed" structure, as confirmed by molecular dynamics simulations.	Histidine	35-38	H3 histone pseudogene 16	Homo sapiens	45-48
9396728-5	1997	Under acidic pH conditions, where His-13 of P21 is loosely bound to the haem iron ("open" conformation), MKP displays appreciable, quasi-reversible electrochemical activity; in contrast, at neutral pH ("closed" conformation) electrochemical behaviour is negligible, indicating that P21 interferes with the electron-transfer properties typical of Mp.	Histidine	34-37	H3 histone pseudogene 16	Homo sapiens	44-47
25701820-0	2015	Two conserved histidines (His490 and His621) on the E2 glycoprotein of hepatitis C virus are critical for CD81-mediated cell entry.	Histidine	14-24	CD81 molecule	Homo sapiens	106-110
25060725-3	2015	The CMD-layer was found to be advantageous in terms of not only immobilization of histidine-tagged recombinant protein A-mediated an antibody against myoglobin (anti-Myo) but also prevention of non-specific binding of myoglobin.	Histidine	82-91	myoglobin	Homo sapiens	218-227
25466186-1	2014	An asparagine or a histidine are present in a similar position in the outer pore region of SK2 and SK3 channels, respectively.	Histidine	19-28	potassium calcium-activated channel subfamily N member 3	Homo sapiens	99-102
25325399-1	2014	Growth hormone releasing peptide, GHRP-6, a hexapeptide (His-(D-Trp)-Ala-Trp-(D-Phe)-Lys-NH2, MW = 872.44 Da) that belongs to a class of synthetic growth hormone secretagogues, can stimulate growth hormone secretion from somatotrophs in several species including humans.	Histidine	57-60	ghrelin and obestatin prepropeptide	Homo sapiens	0-32
25888615-8	2015	Ubiquitination on both HIS(6x)-HA(3x)-IAA1 and Lys-less HIS(6x)-HA(3x)-IAA1 proteins was sensitive to sodium hydroxide treatment, indicative of ubiquitin oxyester formation on serine or threonine residues.	Histidine	23-26	indole-3-acetic acid inducible	Arabidopsis thaliana	38-42
9388263-3	1997	To determine if the equivalent residue in the related thiol ester-containing protein human alpha2-macroglobulin (alpha2M), asparagine 1065, plays a similar role, we have expressed and characterized four alpha2M variants in which this asparagine has been replaced by aspartate, alanine, histidine, or lysine.	Histidine	286-295	alpha-2-macroglobulin	Homo sapiens	113-120
25283443-4	2014	Differences in the enantiomeric specificity of d/l-lactacte formation observed for the DJ-1 superfamily proteins are explained by the presence of a His residue in the active site with essential Cys and Glu residues.	Histidine	148-151	Parkinsonism associated deglycase	Homo sapiens	87-91
9486427-6	1997	Six tryptophan/histidine signals and one tyrosine signal are present in the aromatic part of the CIDNP difference spectrum of SAP.	Histidine	15-24	amyloid P component, serum	Homo sapiens	126-129
25572019-5	2015	We used homo-FRET measurements between fluorescein-E-G-R-chloromethylketone (CK)-Xa [fXa irreversibly inactivated by alkylation of the active site histidine residue with FEGR (FEGR-fXa)] and prothrombinase activity measurements to reveal the balance between fXa dimer formation and fXa-fVa complex formation.	Histidine	147-156	coagulation factor X	Homo sapiens	85-88
25597447-6	2015	Results from electron spin-echo envelope modulation and electron-nuclear double resonance experiments reveal that the six Mn(II)-coordinating histidine residues of Ca(II)- and Mn(II)-bound CP are spectroscopically equivalent.	Histidine	142-151	carbonic anhydrase 2	Homo sapiens	164-170
9376358-0	1997	Identification of the predominant non-native histidine ligand in unfolded cytochrome c.	Histidine	45-54	cytochrome c, somatic	Equus caballus	74-86
25283443-6	2014	The mechanism of DJ-1 glyoxalase provides a basis for understanding the His residue-based stereospecificity.	Histidine	72-75	Parkinsonism associated deglycase	Homo sapiens	17-21
25421803-1	2014	BACKGROUND: The histidine ammonia-lyse gene (HAL) encodes the histidine ammonia-lyase, which catalyzes the first reaction of histidine catabolism.	Histidine	16-25	histidine ammonia-lyase	Bos taurus	45-48
9340197-0	1997	A cluster of cytoplasmic histidine residues specifies pH dependence of the AE2 plasma membrane anion exchanger.	Histidine	25-34	solute carrier family 4 member 2	Homo sapiens	75-78
25323582-7	2015	The ADH1B*47Arg allele was found to be associated with increased risk of HNC in Asians, with the pooled odds ratios (ORs) (Arg/Arg vs. Arg/His + His/His: OR = 2.35, 95% CI = 1.56-3.55, P &lt; 0.0001) in all eight studies.	Histidine	139-142	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	4-9
25323582-7	2015	The ADH1B*47Arg allele was found to be associated with increased risk of HNC in Asians, with the pooled odds ratios (ORs) (Arg/Arg vs. Arg/His + His/His: OR = 2.35, 95% CI = 1.56-3.55, P &lt; 0.0001) in all eight studies.	Histidine	145-148	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	4-9
25323582-7	2015	The ADH1B*47Arg allele was found to be associated with increased risk of HNC in Asians, with the pooled odds ratios (ORs) (Arg/Arg vs. Arg/His + His/His: OR = 2.35, 95% CI = 1.56-3.55, P &lt; 0.0001) in all eight studies.	Histidine	145-148	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	4-9
25652851-6	2015	RESULTS: SDS-PAGE and Western blotting confirmed that a soluble recombinant His-SpiC protein of 19.2 ku was expressed in BL21(DE3) cells.	Histidine	76-79	Spi-C transcription factor	Homo sapiens	80-84
25652851-7	2015	SPF chicken antibodies against GST-SpiC could recognize His-SpiC, indicating that His-SpiC had a good immunogenicity.	Histidine	56-59	Spi-C transcription factor	Homo sapiens	35-39
25421803-1	2014	BACKGROUND: The histidine ammonia-lyse gene (HAL) encodes the histidine ammonia-lyase, which catalyzes the first reaction of histidine catabolism.	Histidine	16-25	histidine ammonia-lyase	Bos taurus	62-85
25652851-7	2015	SPF chicken antibodies against GST-SpiC could recognize His-SpiC, indicating that His-SpiC had a good immunogenicity.	Histidine	56-59	Spi-C transcription factor	Homo sapiens	60-64
25652851-7	2015	SPF chicken antibodies against GST-SpiC could recognize His-SpiC, indicating that His-SpiC had a good immunogenicity.	Histidine	56-59	Spi-C transcription factor	Homo sapiens	60-64
25438756-4	2014	Initially, we identified and validated PCNA methionine 40 (M40) and histidine 44 (H44) as essential residues for PCNA/PIP-box interactions in general and, more specifically, for efficient PCNA loading onto chromatin within cells.	Histidine	68-77	proliferating cell nuclear antigen	Homo sapiens	113-117
25652851-7	2015	SPF chicken antibodies against GST-SpiC could recognize His-SpiC, indicating that His-SpiC had a good immunogenicity.	Histidine	82-85	Spi-C transcription factor	Homo sapiens	35-39
25652851-7	2015	SPF chicken antibodies against GST-SpiC could recognize His-SpiC, indicating that His-SpiC had a good immunogenicity.	Histidine	82-85	Spi-C transcription factor	Homo sapiens	60-64
25652851-7	2015	SPF chicken antibodies against GST-SpiC could recognize His-SpiC, indicating that His-SpiC had a good immunogenicity.	Histidine	82-85	Spi-C transcription factor	Homo sapiens	60-64
25652851-9	2015	CONCLUSION: The recombinant His-SpiC was successfully expressed and the indirect ELISA with it as coating antigen could be used as DIVA method for the related vaccine of pullorum disease.	Histidine	28-31	Spi-C transcription factor	Homo sapiens	32-36
9196036-2	1997	Using histidine-tagged TBP for affinity-purification of TBP-bound proteins, we isolated a 49-kD protein termed TBP-interacting protein 49 (TIP49) from rat liver nuclear extracts.	Histidine	6-15	TATA box binding protein	Rattus norvegicus	23-26
9196036-2	1997	Using histidine-tagged TBP for affinity-purification of TBP-bound proteins, we isolated a 49-kD protein termed TBP-interacting protein 49 (TIP49) from rat liver nuclear extracts.	Histidine	6-15	TATA box binding protein	Rattus norvegicus	56-59
9196036-2	1997	Using histidine-tagged TBP for affinity-purification of TBP-bound proteins, we isolated a 49-kD protein termed TBP-interacting protein 49 (TIP49) from rat liver nuclear extracts.	Histidine	6-15	TATA box binding protein	Rattus norvegicus	56-59
25438756-4	2014	Initially, we identified and validated PCNA methionine 40 (M40) and histidine 44 (H44) as essential residues for PCNA/PIP-box interactions in general and, more specifically, for efficient PCNA loading onto chromatin within cells.	Histidine	68-77	proliferating cell nuclear antigen	Homo sapiens	113-117
25554946-14	2015	Conversely, in Ngb, the reduction mechanism does not rely on the delivery of a proton from the histidine side chain, as His64 mutants show the fastest reduction rates.	Histidine	95-104	neuroglobin	Homo sapiens	15-18
9232197-0	1997	Histidine modification of human serum butyrylcholinesterase.	Histidine	0-9	butyrylcholinesterase	Homo sapiens	38-59
24865971-5	2014	Amino acid analyses reveal that Hpm1p is responsible for all of the detectable protein histidine methylation in yeast.	Histidine	87-96	protein-histidine N-methyltransferase	Saccharomyces cerevisiae S288C	32-37
9232197-12	1997	The results indicate that DPC modifies some essential histidine side chains in BChE, including the functional histidyl residue found at the active site.	Histidine	54-63	butyrylcholinesterase	Homo sapiens	79-83
25542361-1	2015	We report a turn-on phosphorescence probe for detection of histidine based on Co(2+)-adsorbed N-acetyl-L-cysteine (NAC) capped Mn: ZnS quantum dots (QDs) which is directly synthesized by the hydrothermal method.	Histidine	59-68	X-linked Kx blood group	Homo sapiens	115-118
25542361-3	2015	The phosphorescence of Co(2+)-adsorbed NAC-Mn: ZnS QDs can be recovered by binding of Co(2+) with histidine.	Histidine	98-107	X-linked Kx blood group	Homo sapiens	39-42
9092568-4	1997	When expressed in Xenopus laevis oocytes, PHT1 cRNA induced high affinity proton-dependent histidine transport activity.	Histidine	91-100	solute carrier family 15 member 4 S homeolog	Xenopus laevis	42-46
24699373-9	2014	Bap2-mediated leucine import was inhibited by some amino acids according to the following order of severity: phenylalanine, leucine&gt;isoleucine&gt;methionine, tyrosine&gt;valine&gt;tryptophan; histidine and asparagine had no effect.	Histidine	195-204	branched-chain amino acid permease BAP2	Saccharomyces cerevisiae S288C	0-4
9116048-5	1997	Recombinant rat C5a with a 6 histidine tag at the N-terminus was expressed in bacteria, purified and renatured.	Histidine	29-38	complement C5	Rattus norvegicus	16-19
9048595-2	1997	Somatostatin inhibited basal and gastrin-stimulated histamine synthesis through a dual mechanism involving a decrease in the affinity of histidine decarboxylase (HDC) for its substrate (L-histidine) and a reduction in the number of functional HDC molecules.	Histidine	186-197	histidine decarboxylase	Oryctolagus cuniculus	137-160
25542361-7	2015	Co(2+)-adsorbed NAC-Mn: ZnS QDs show high sensitivity and good selectivity to histidine over other amino acids, metal ions and co-existing substances.	Histidine	78-87	X-linked Kx blood group	Homo sapiens	16-19
25699148-2	2015	Replacement of His(6) by an aminoindoloazepinone (Aia) or aminobenzazepinone (Aba) moiety led to hMC4R and hMC5R selective agonist and antagonist ligands, respectively (tetrapeptides 1 to 3 and 4, respectively).	Histidine	15-18	melanocortin 4 receptor	Homo sapiens	97-102
25699148-2	2015	Replacement of His(6) by an aminoindoloazepinone (Aia) or aminobenzazepinone (Aba) moiety led to hMC4R and hMC5R selective agonist and antagonist ligands, respectively (tetrapeptides 1 to 3 and 4, respectively).	Histidine	15-18	melanocortin 5 receptor	Homo sapiens	107-112
9048595-4	1997	Furthermore, forskolin was shown to reverse the inhibitory effect of H-89 and to prevent the somatostatin-induced reduction in HDC affinity for L-histidine.	Histidine	144-155	histidine decarboxylase	Oryctolagus cuniculus	127-130
24808179-6	2014	Moreover, the C-terminal Cys/His-rich domain of PCSK9 is crucial in the regulation of PCSK9 activity, and we demonstrated by far-Western blot assay that the M1 and M2 domains are necessary for the specific interaction of PCSK9"s C-terminal Cys/His-rich domain and AnxA2.	Histidine	29-32	proprotein convertase subtilisin/kexin type 9	Homo sapiens	48-53
9184002-3	1997	The patient had a G to A transition at codon 156 of the keratin K10 gene, which resulted in an arginine (Arg)--&gt;histidine (His) substitution in the helix initiation peptide of the highly-conserved 1A domain in keratin K10.	Histidine	115-124	keratin 10	Homo sapiens	64-67
9184002-3	1997	The patient had a G to A transition at codon 156 of the keratin K10 gene, which resulted in an arginine (Arg)--&gt;histidine (His) substitution in the helix initiation peptide of the highly-conserved 1A domain in keratin K10.	Histidine	126-129	keratin 10	Homo sapiens	64-67
9184002-3	1997	The patient had a G to A transition at codon 156 of the keratin K10 gene, which resulted in an arginine (Arg)--&gt;histidine (His) substitution in the helix initiation peptide of the highly-conserved 1A domain in keratin K10.	Histidine	126-129	keratin 10	Homo sapiens	221-224
25230085-1	2014	Within the phospholipase A2 (PLA2) superfamily, secreted PLA2 (sPLA2) enzymes comprise the largest family that contains 11 to 12 mammalian isoforms with a conserved His-Asp catalytic dyad.	Histidine	165-168	phospholipase A2 group IIA	Homo sapiens	63-68
25550928-7	2014	Overall, a significant association was found between the XPG Asp1104His polymorphism and the risk of gastrointestinal cancers (dominant model: OR = 1.15, 95% CI: 1.05-1.26; His/His vs. Asp/Asp: OR = 1.15, 95% CI: 1.01-1.32).	Histidine	68-71	ERCC excision repair 5, endonuclease	Homo sapiens	57-60
24808179-6	2014	Moreover, the C-terminal Cys/His-rich domain of PCSK9 is crucial in the regulation of PCSK9 activity, and we demonstrated by far-Western blot assay that the M1 and M2 domains are necessary for the specific interaction of PCSK9"s C-terminal Cys/His-rich domain and AnxA2.	Histidine	29-32	proprotein convertase subtilisin/kexin type 9	Homo sapiens	86-91
24808179-6	2014	Moreover, the C-terminal Cys/His-rich domain of PCSK9 is crucial in the regulation of PCSK9 activity, and we demonstrated by far-Western blot assay that the M1 and M2 domains are necessary for the specific interaction of PCSK9"s C-terminal Cys/His-rich domain and AnxA2.	Histidine	29-32	proprotein convertase subtilisin/kexin type 9	Homo sapiens	86-91
25151410-5	2014	The histidine forms eight hydrogen bonds with HisRS of which six engage the amino and carboxylate groups of this amino acid.	Histidine	4-13	histidyl-tRNA synthetase 2, mitochondrial	Homo sapiens	46-51
24808179-6	2014	Moreover, the C-terminal Cys/His-rich domain of PCSK9 is crucial in the regulation of PCSK9 activity, and we demonstrated by far-Western blot assay that the M1 and M2 domains are necessary for the specific interaction of PCSK9"s C-terminal Cys/His-rich domain and AnxA2.	Histidine	29-32	annexin A2	Homo sapiens	264-269
24808179-6	2014	Moreover, the C-terminal Cys/His-rich domain of PCSK9 is crucial in the regulation of PCSK9 activity, and we demonstrated by far-Western blot assay that the M1 and M2 domains are necessary for the specific interaction of PCSK9"s C-terminal Cys/His-rich domain and AnxA2.	Histidine	244-247	proprotein convertase subtilisin/kexin type 9	Homo sapiens	48-53
25295538-2	2014	Here, through transcriptional profiling of genetically labeled cardiomyocytes, we identified expression of Purkinje cell protein-4 (Pcp4), a putative regulator of calmodulin and Ca2+/calmodulin-dependent kinase II (CaMKII) signaling, exclusively within the His-Purkinje network.	Histidine	257-260	calcium/calmodulin-dependent protein kinase II, beta	Mus musculus	215-221
25160622-4	2014	AtCM1 is activated by tryptophan with phenylalanine and tyrosine acting as negative effectors; however, tryptophan, cysteine, and histidine activate AtCM3.	Histidine	130-139	chorismate mutase 3	Arabidopsis thaliana	149-154
9037006-5	1997	RNA-dependent phosphorylation was observed both for a histidine-tagged recombinant human C1 hnRNP protein added to nuclear extracts and also for the endogenous C1 hnRNP protein.	Histidine	54-63	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	92-97
24808179-6	2014	Moreover, the C-terminal Cys/His-rich domain of PCSK9 is crucial in the regulation of PCSK9 activity, and we demonstrated by far-Western blot assay that the M1 and M2 domains are necessary for the specific interaction of PCSK9"s C-terminal Cys/His-rich domain and AnxA2.	Histidine	244-247	proprotein convertase subtilisin/kexin type 9	Homo sapiens	86-91
24808179-6	2014	Moreover, the C-terminal Cys/His-rich domain of PCSK9 is crucial in the regulation of PCSK9 activity, and we demonstrated by far-Western blot assay that the M1 and M2 domains are necessary for the specific interaction of PCSK9"s C-terminal Cys/His-rich domain and AnxA2.	Histidine	244-247	proprotein convertase subtilisin/kexin type 9	Homo sapiens	86-91
24866374-4	2014	In this study we describe a novel, single-well OGT enzyme assay that utilizes 6 x His-tagged substrates, a chemoselective chemical reaction, and unpurified OGT.	Histidine	82-85	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	47-50
9016645-6	1997	A recombinant histidine-tagged Reb1 protein bearing the rDNA binding domain has two homologous, sequence-specific binding sites in the S. pomber DNA intergenic spacer, located between 289 and 480 nt downstream of the end of the approximately 25S rRNA coding sequences.	Histidine	14-23	DNA-binding protein REB1	Saccharomyces cerevisiae S288C	31-35
25100752-2	2014	In this study, we investigated the pharmacological properties of HIS-388 (N-[(1R,2s,3S,5s,7s)-5-hydroxyadamantan-2-yl]-3-(pyridin-2-yl) isoxazole-4-carboxamide), a newly synthesized 11beta-HSD1 inhibitor, using several mouse models.	Histidine	65-68	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	182-193
25100325-0	2014	The C113D mutation in human Pin1 causes allosteric structural changes in the phosphate binding pocket of the PPIase domain through the tug of war in the dual-histidine motif.	Histidine	158-167	peptidylprolyl isomerase like 1	Homo sapiens	109-115
24370479-6	2014	As for the C-terminal His-tagged rDlP5betaR the catalytic efficiency for progesterone was highest for the full-length rDlP5betaRc whereas the N-terminal truncated forms preferred 2-cyclohexen-1-one as the substrate.	Histidine	22-25	dynein, axonemal, heavy chain 5	Rattus norvegicus	33-38
24833547-0	2014	Histidine supplementation alleviates inflammation in the adipose tissue of high-fat diet-induced obese rats via the NF-kappaB- and PPARgamma-involved pathways.	Histidine	0-9	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	131-140
24833547-10	2014	The results also revealed that the expression of adiponectin was markedly increased both in the serum and in the adipose tissue after histidine supplementation, accompanied by the activation of PPARgamma (P= 0 021).	Histidine	134-143	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	49-60
24833547-10	2014	The results also revealed that the expression of adiponectin was markedly increased both in the serum and in the adipose tissue after histidine supplementation, accompanied by the activation of PPARgamma (P= 0 021).	Histidine	134-143	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	194-203
24833547-11	2014	These findings indicate that histidine is an effective candidate for ameliorating inflammation and oxidative stress in obese individuals via the NF-kappaB- and PPARgamma-involved pathways.	Histidine	29-38	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	160-169
9042366-4	1997	FucT-VI activity was found to be particularly sensitive to the histidine-selective reagent diethylpyrocarbonate and the cysteine reagent N-ethylmaleimide, with IC50 values of less than 200 microM.	Histidine	63-72	fucosyltransferase 6	Homo sapiens	0-7
9042366-8	1997	These data suggest that in addition to an NEM-reactive cysteine in, or adjacent to, the substrate-binding site of the enzyme, FucT-VI possesses histidine residue(s) that are essential for enzyme activity.	Histidine	144-153	fucosyltransferase 6	Homo sapiens	126-133
9063899-9	1997	The distinct structural feature of this archaeal ferredoxin lies in the zinc-binding center where the zinc ion is tetrahedrally ligated by four amino acid residues (His 16, His 19, and His 34 from the N-terminal extension, and Asp 76 from the core fold).	Histidine	165-168	4Fe-4S binding protein	Sulfurisphaera tokodaii str. 7	49-59
25221773-0	2014	In silico study of fragile histidine triad interaction domains with MDM2 and p53.	Histidine	27-36	MDM2 proto-oncogene	Homo sapiens	68-72
24742669-0	2014	Residue histidine 50 plays a key role in protecting alpha-synuclein from aggregation at physiological pH.	Histidine	8-17	synuclein alpha	Homo sapiens	52-67
25221773-1	2014	BACKGROUND: Fragile histidine triad (FHIT) is considered as a member of the histidine triad (HIT) nucleotide-binding protein superfamily regarded as a putative tumor suppressor executing crucial role in inhibiting p53 degradation by MDM2.	Histidine	20-29	MDM2 proto-oncogene	Homo sapiens	233-237
25221773-1	2014	BACKGROUND: Fragile histidine triad (FHIT) is considered as a member of the histidine triad (HIT) nucleotide-binding protein superfamily regarded as a putative tumor suppressor executing crucial role in inhibiting p53 degradation by MDM2.	Histidine	76-85	MDM2 proto-oncogene	Homo sapiens	233-237
25606432-4	2014	L23a is highly basic, containing a combined 45 Arg, Lys, and His residues and only 14 Asp and Glu residues.	Histidine	61-64	ribosomal protein L23a	Homo sapiens	0-4
24742669-2	2014	Recently, substitution of histidine 50 in alphaSyn with a glutamine, H50Q, was identified as a new familial PD mutant.	Histidine	26-35	synuclein alpha	Homo sapiens	42-50
24742669-6	2014	Histidine carries a partial positive charge at neutral pH, and so our result suggests that positively charged His-50 plays a role in protecting alphaSyn from aggregation under physiological conditions.	Histidine	0-9	synuclein alpha	Homo sapiens	144-152
24742669-6	2014	Histidine carries a partial positive charge at neutral pH, and so our result suggests that positively charged His-50 plays a role in protecting alphaSyn from aggregation under physiological conditions.	Histidine	0-3	synuclein alpha	Homo sapiens	144-152
24652292-4	2014	Its transport properties and kinetic parameters demonstrate that SLC25A29 transports arginine, lysine, homoarginine, methylarginine and, to a much lesser extent, ornithine and histidine.	Histidine	176-185	solute carrier family 25 member 29	Homo sapiens	65-73
24815030-6	2014	We then describe single-particle fluorescence imaging experiments in which we follow the effect of these histidine mutations on susceptibility to Hsc70-dependent uncoating.	Histidine	105-114	heat shock protein family A (Hsp70) member 8	Homo sapiens	146-151
24733837-8	2014	We identified a histidine residue (H434 in S6) near the activation gate in the pore critical for (1)O2 modulation of HCN function.	Histidine	16-25	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	117-120
24905281-4	2014	Using an assay that mimics Rac1 membrane anchoring by using Rac1-His and liposomes containing Ni(2+)-NTA modified lipids, we demonstrate that intrinsic Tiam1 DH-PH activity increases when Rac1 is anchored in a PtdIns5P-enriched environment.	Histidine	65-68	Rac family small GTPase 1	Homo sapiens	60-64
24905281-4	2014	Using an assay that mimics Rac1 membrane anchoring by using Rac1-His and liposomes containing Ni(2+)-NTA modified lipids, we demonstrate that intrinsic Tiam1 DH-PH activity increases when Rac1 is anchored in a PtdIns5P-enriched environment.	Histidine	65-68	TIAM Rac1 associated GEF 1	Homo sapiens	152-157
24905281-4	2014	Using an assay that mimics Rac1 membrane anchoring by using Rac1-His and liposomes containing Ni(2+)-NTA modified lipids, we demonstrate that intrinsic Tiam1 DH-PH activity increases when Rac1 is anchored in a PtdIns5P-enriched environment.	Histidine	65-68	Rac family small GTPase 1	Homo sapiens	60-64
24785355-4	2014	Using galactose and histidine growth complementation assays, we demonstrate that 0.3% of the gal3  cell population responds to galactose.	Histidine	20-29	transcriptional regulator GAL3	Saccharomyces cerevisiae S288C	93-97
24467436-9	2014	NAT enzymes act through a catalytic triad of Cys, His and Asp with the architecture of the active site-modulating specificity.	Histidine	50-53	bromodomain containing 2	Homo sapiens	0-3
24821782-2	2014	Here, we report the identification of a unique cytosolic nucleic acid cosensor in human airway epithelial cells and fibroblasts: DEAH (Asp-Glu-Ala-His) box polypeptide 29 (DHX29), a member of the DExD/H (Asp-Glu-x-Asp/His)-box helicase family.	Histidine	147-150	DExH-box helicase 29	Homo sapiens	172-177
24821782-2	2014	Here, we report the identification of a unique cytosolic nucleic acid cosensor in human airway epithelial cells and fibroblasts: DEAH (Asp-Glu-Ala-His) box polypeptide 29 (DHX29), a member of the DExD/H (Asp-Glu-x-Asp/His)-box helicase family.	Histidine	218-221	DExH-box helicase 29	Homo sapiens	172-177
24417816-8	2014	A nucleotide variation in the Oxidative Stress-Induced Growth Inhibitor 1 (OSGIN1) gene (nt 1494: G-A) resulted in an amino acid substitution (codon 438: Arg-His).	Histidine	158-161	oxidative stress induced growth inhibitor 1	Homo sapiens	30-73
24627494-3	2014	We explored the hypothesis that a conserved His-rich cluster (His-Gly-His-His) in the linker region connecting its two catalytic domains senses pH and affects PAM trafficking by mutating these His residues to Ala (Ala-Gly-Ala-Ala; H3A).	Histidine	44-47	zinc finger protein 106	Mus musculus	231-234
24627494-3	2014	We explored the hypothesis that a conserved His-rich cluster (His-Gly-His-His) in the linker region connecting its two catalytic domains senses pH and affects PAM trafficking by mutating these His residues to Ala (Ala-Gly-Ala-Ala; H3A).	Histidine	62-65	zinc finger protein 106	Mus musculus	231-234
24627494-3	2014	We explored the hypothesis that a conserved His-rich cluster (His-Gly-His-His) in the linker region connecting its two catalytic domains senses pH and affects PAM trafficking by mutating these His residues to Ala (Ala-Gly-Ala-Ala; H3A).	Histidine	62-65	zinc finger protein 106	Mus musculus	231-234
24627494-3	2014	We explored the hypothesis that a conserved His-rich cluster (His-Gly-His-His) in the linker region connecting its two catalytic domains senses pH and affects PAM trafficking by mutating these His residues to Ala (Ala-Gly-Ala-Ala; H3A).	Histidine	62-65	zinc finger protein 106	Mus musculus	231-234
24627494-3	2014	We explored the hypothesis that a conserved His-rich cluster (His-Gly-His-His) in the linker region connecting its two catalytic domains senses pH and affects PAM trafficking by mutating these His residues to Ala (Ala-Gly-Ala-Ala; H3A).	Histidine	62-65	zinc finger protein 106	Mus musculus	231-234
24282278-8	2014	Moreover, His-MDA-7, after binding to its cognate receptors (IL-20R1/IL-20R2 or IL-22R/IL-20R2), induces intracellular signaling by phosphorylation of p38 MAPK, leading to transcription of a family of growth arrest and DNA damage inducible (GADD) genes, culminating in apoptosis.	Histidine	10-13	interleukin 20 receptor subunit alpha	Homo sapiens	61-68
24417816-8	2014	A nucleotide variation in the Oxidative Stress-Induced Growth Inhibitor 1 (OSGIN1) gene (nt 1494: G-A) resulted in an amino acid substitution (codon 438: Arg-His).	Histidine	158-161	oxidative stress induced growth inhibitor 1	Homo sapiens	75-81
24293060-5	2014	The nucleotide change results in the substitution of an evolutionarily highly conserved tyrosine by histidine (p.Y689H) in the M41 peptidase domain of AFG3L2.	Histidine	100-109	AFG3 like matrix AAA peptidase subunit 2	Homo sapiens	151-157
25009988-8	2014	Results showed that the protein BANF1 fusion with the N-terminally His-tagged form gave rise to the accumulation of an expected 14 kD polypeptide that formed inclusion bodies.	Histidine	67-70	barrier-to-autointegration factor	Ailuropoda melanoleuca	32-37
24403080-2	2014	The C-terminal cytosolic domain of mitoNEET hosts a redox-active [2Fe-2S] cluster via an unusual ligand arrangement of three cysteine residues and one histidine residue.	Histidine	151-160	CDGSH iron sulfur domain 1	Homo sapiens	35-43
24121506-5	2013	Within L1C domains, five amino acid residues (Leu-135, Gly-188, Arg-244, and vicinal His-318 and Lys-319) were identified as IRR-specific by species conservation analysis of the IR family.	Histidine	85-88	insulin receptor related receptor	Homo sapiens	125-128
24260525-5	2013	In addition, detailed analysis demonstrated that USP25 cleaved lysine 48- and lysine 63-linked polyubiquitin chains in vitro and in vivo, and its deubiquitinating enzyme (DUB) activity, were dependent on a cysteine residue (Cys178) and a histidine residue (His607).	Histidine	238-247	ubiquitin specific peptidase 25	Homo sapiens	49-54
24447265-5	2014	Two residues in the PIR1 phosphate-binding loop (P-loop), a histidine (H154) downstream of C152 and an asparagine (N157) preceding R158, make close contacts with the active site phosphate, and their nonaliphatic side chains are essential for phosphatase activity in vitro.	Histidine	60-69	dual specificity phosphatase 11	Homo sapiens	20-24
24026233-3	2013	In this study, the full-length mouse alpha-CP2 gene was expressed in an insoluble form with an N-terminal histidine tag in Escherichia coli and purified for homogeneity using affinity column chromatography.	Histidine	106-115	poly(rC) binding protein 2	Mus musculus	37-46
24449363-4	2014	We detected an association between HNC and CYP1A1 6310C&gt;T (TT) and CYP2D6 Arg365His (His/His) variant carriers (OR 1.75, P = 0.008 and OR 1.66, P = 0.016, respectively).	Histidine	83-86	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	43-49
23706761-6	2013	An interesting coordination mode has been proposed for the IRT1-Zn(2+) complex, in which imidazoles from two histidines (His-96 and His-116), a cysteine thiolate (Cys-109) and one of a glutamic acid carboxyl group are involved.	Histidine	109-119	iron-regulated transporter 1	Arabidopsis thaliana	59-63
23706761-6	2013	An interesting coordination mode has been proposed for the IRT1-Zn(2+) complex, in which imidazoles from two histidines (His-96 and His-116), a cysteine thiolate (Cys-109) and one of a glutamic acid carboxyl group are involved.	Histidine	121-124	iron-regulated transporter 1	Arabidopsis thaliana	59-63
23706761-6	2013	An interesting coordination mode has been proposed for the IRT1-Zn(2+) complex, in which imidazoles from two histidines (His-96 and His-116), a cysteine thiolate (Cys-109) and one of a glutamic acid carboxyl group are involved.	Histidine	132-135	iron-regulated transporter 1	Arabidopsis thaliana	59-63
24449363-4	2014	We detected an association between HNC and CYP1A1 6310C&gt;T (TT) and CYP2D6 Arg365His (His/His) variant carriers (OR 1.75, P = 0.008 and OR 1.66, P = 0.016, respectively).	Histidine	88-91	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	43-49
24000822-5	2014	The inhibitor was stabilized by hydrogen bonding interactions with residues Arg 145, Asn 566, Pro 731 and His 732 of hECE-1.	Histidine	106-109	endothelin converting enzyme 1	Homo sapiens	117-123
23733202-2	2013	XRCC1 codon 280 polymorphism is an Arg-His change in the XRCC1 gene.	Histidine	39-42	X-ray repair cross complementing 1	Homo sapiens	0-5
24056075-2	2013	To establish an ultrasensitive receptor-binding assay for INSL3-RXFP2 interaction studies, in the present work we labeled a recombinant INSL3 peptide with a newly developed nanoluciferase (NanoLuc) reporter through a convenient chemical conjugation approach, including the introduction of an active disulfide bond to INSL3 by chemical modification and engineering of a 6x His-Cys-NanoLuc carrying a unique exposed cysteine at the N-terminus.	Histidine	372-375	insulin like 3	Homo sapiens	136-141
24056075-2	2013	To establish an ultrasensitive receptor-binding assay for INSL3-RXFP2 interaction studies, in the present work we labeled a recombinant INSL3 peptide with a newly developed nanoluciferase (NanoLuc) reporter through a convenient chemical conjugation approach, including the introduction of an active disulfide bond to INSL3 by chemical modification and engineering of a 6x His-Cys-NanoLuc carrying a unique exposed cysteine at the N-terminus.	Histidine	372-375	insulin like 3	Homo sapiens	136-141
24579556-9	2013	Direct sequencing detected a recurrent heterozygous missense c.1877A &gt; G mutation in exon 14 of the TGFBI gene, resulting in substitution of histidine with arginine (p.H626R).	Histidine	144-153	transforming growth factor beta induced	Homo sapiens	103-108
24219289-7	2013	(iv) His-CIRH1A is phosphorylated at Thr(131) by a mitotic Xenopus egg extract, and binding with GST-UTP15 and GST-WDR43 is suppressed.	Histidine	5-8	UTP4 small subunit processome component L homeolog	Xenopus laevis	9-15
24219289-7	2013	(iv) His-CIRH1A is phosphorylated at Thr(131) by a mitotic Xenopus egg extract, and binding with GST-UTP15 and GST-WDR43 is suppressed.	Histidine	5-8	UTP15, small subunit processome component L homeolog	Xenopus laevis	101-106
23514341-2	2013	Intensive catalytic activity in solvolysis of sterically hindered Z-Aib-Aib-ONp under ambient conditions was observed for structures bearing the catalytic triad as well as for structures with the peptide fragment shortened to a dipeptide or even a single Ser, Glu or His residue, but not for structures bearing alanine or phenylalanine residues.	Histidine	267-270	ANIB1	Homo sapiens	68-71
24116384-6	2013	It is well-known that the coordination of copper with imidazoles on Histidine-13 and 14 (H13, H14) of Abeta peptides could initialize covalent cross-linking of Abeta.	Histidine	68-77	amyloid beta (A4) precursor protein	Mus musculus	102-107
23514341-2	2013	Intensive catalytic activity in solvolysis of sterically hindered Z-Aib-Aib-ONp under ambient conditions was observed for structures bearing the catalytic triad as well as for structures with the peptide fragment shortened to a dipeptide or even a single Ser, Glu or His residue, but not for structures bearing alanine or phenylalanine residues.	Histidine	267-270	ANIB1	Homo sapiens	72-75
23652332-5	2013	Here, we reported that the His-rich domain of selenoprotein P (SelP-H) and the Sec-to-Cys mutant selenoprotein M (SelM") are capable of binding transition metal ions and modulating the Zn(2+)-mediated Abeta aggregation, ROS production and neurotoxicity.	Histidine	27-30	selenoprotein M	Homo sapiens	114-119
24116384-6	2013	It is well-known that the coordination of copper with imidazoles on Histidine-13 and 14 (H13, H14) of Abeta peptides could initialize covalent cross-linking of Abeta.	Histidine	68-77	amyloid beta (A4) precursor protein	Mus musculus	160-165
23971743-1	2013	Eukaryotic and archaeal elongation factor 2 contains a unique post-translationally modified histidine residue, named diphthamide.	Histidine	92-101	eukaryotic translation elongation factor 2	Homo sapiens	24-43
23785305-3	2013	A heterozygous Arg-to-His missense mutation (p.R930H) in the ribosomal GTPase BMS1 is identified in ACC that is associated with a delay in 18S rRNA maturation, consistent with a role of BMS1 in processing of pre-rRNAs of the small ribosomal subunit.	Histidine	22-25	BMS1, ribosome biogenesis factor	Mus musculus	78-82
23785305-3	2013	A heterozygous Arg-to-His missense mutation (p.R930H) in the ribosomal GTPase BMS1 is identified in ACC that is associated with a delay in 18S rRNA maturation, consistent with a role of BMS1 in processing of pre-rRNAs of the small ribosomal subunit.	Histidine	22-25	BMS1, ribosome biogenesis factor	Mus musculus	186-190
9015380-5	1997	A yeast strain was created in which the essential 64-kDa glycoprotein Nlt1p subunit of the oligosaccharyl transferase was modified by the addition of a 22-residue carboxy-terminal affinity tag; the tag included both an 8-residue FLAG epitope and a 6-residue histidine motif.	Histidine	258-267	dolichyl-diphosphooligosaccharide--protein glycotransferase subunit OST1	Saccharomyces cerevisiae S288C	70-75
24224020-7	2013	ZNF24 containing histidine to leucine mutations that disrupt the structure of ZF1 or/and ZF2 retains appropriate nuclear localization, indicating that neither the tertiary structure of the zinc fingers nor specific DNA binding are necessary for nuclear localization.	Histidine	17-26	zinc finger protein 24	Homo sapiens	0-5
8993325-0	1997	A lysine 73--&gt;histidine variant of yeast iso-1-cytochrome c: evidence for a native-like intermediate in the unfolding pathway and implications for m value effects.	Histidine	17-26	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	44-49
8993325-1	1997	In this paper we report thermodynamic studies on a variant of yeast iso-1-cytochrome c in which a surface lysine residue at position 73 has been replaced with a histidine (H73).	Histidine	161-170	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	68-73
23717386-4	2013	The structure of the soluble domain of NAF-1 shows that it forms a homodimer with each protomer containing a [2Fe-2S] cluster bound by 3 Cys and one His.	Histidine	149-152	CDGSH iron sulfur domain 2	Homo sapiens	39-44
23500601-0	2013	Appraisal of sildenafil binding on the structure and promiscuous esterase activity of native and histidine-modified forms of carbonic anhydrase II.	Histidine	97-106	carbonic anhydrase 2	Homo sapiens	125-146
24098330-4	2013	The purified His-tag fusion proteins of W69 and W106 reduced H2O2 and t-butyl hydroperoxide (t-BHP) using glutathione (GSH) or thioredoxin (Trx) as an electron donor in vitro, showing their peroxidase activity toward H2O2 and toxic organic hydroperoxide.	Histidine	13-16	thioredoxin	Homo sapiens	127-138
23592913-6	2013	Sequencing of the candidate genes revealed a heterozygous c. 139G&gt;C change in the coding sequence of the connexin 50 gene (gap junction protein, alpha 8 [GJA8]), which results in the substitution of a wild-type aspartic acid with a histidine (D47H).	Histidine	235-244	gap junction protein alpha 8	Homo sapiens	108-119
23592913-6	2013	Sequencing of the candidate genes revealed a heterozygous c. 139G&gt;C change in the coding sequence of the connexin 50 gene (gap junction protein, alpha 8 [GJA8]), which results in the substitution of a wild-type aspartic acid with a histidine (D47H).	Histidine	235-244	gap junction protein alpha 8	Homo sapiens	126-155
23592913-6	2013	Sequencing of the candidate genes revealed a heterozygous c. 139G&gt;C change in the coding sequence of the connexin 50 gene (gap junction protein, alpha 8 [GJA8]), which results in the substitution of a wild-type aspartic acid with a histidine (D47H).	Histidine	235-244	gap junction protein alpha 8	Homo sapiens	157-161
8995843-0	1996	HCN, a triple-resonance NMR technique for selective observation of histidine and tryptophan side chains in 13C/15N-labeled proteins.	Histidine	67-76	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	0-3
8995843-1	1996	HCN, a new 3D NMR technique for stepwise coherence transfer from 1H to 13C to 15N and reverse through direct spin couplings 1JCH and 1JCN, is presented as a method for detection and assignment of histidine and tryptophan side-chain 1H, 13C, and 15N resonances in uniformly 13C/15N-labeled proteins.	Histidine	196-205	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	0-3
24098330-4	2013	The purified His-tag fusion proteins of W69 and W106 reduced H2O2 and t-butyl hydroperoxide (t-BHP) using glutathione (GSH) or thioredoxin (Trx) as an electron donor in vitro, showing their peroxidase activity toward H2O2 and toxic organic hydroperoxide.	Histidine	13-16	thioredoxin	Homo sapiens	140-143
23795473-1	2013	Strain MG 1655+hisGr hisL"-Delta, purR, which produces histidine with a weight yield of approximately 12% from glucose, was constructed through directed chromosomal modifications of the laboratory Escherichia coli strain MG 1655+, which has a known genome sequence.	Histidine	55-64	DNA-binding transcriptional repressor PurR	Escherichia coli str. K-12 substr. MG1655	34-38
8931561-3	1996	Peptide mapping of the reaction products by mass spectrometry showed that, with low DEP:M-CSF ratios (&lt; 50:1), there was selective modification of histidine residues, whereas at higher ratios (&gt; 50:1), Tyr and Lys residues were also modified.	Histidine	150-159	colony stimulating factor 1	Homo sapiens	88-93
23818523-8	2013	However, PEDF-R polypeptides without the His(203)-Leu(232) region lost the PEDF affinity that stimulated their enzymatic activity.	Histidine	41-44	patatin like phospholipase domain containing 2	Homo sapiens	9-15
22967951-6	2013	MsrA adsorbs on the hydrophobic carbon electrode surface preferentially through the three hydrophobic domains, C1, C2 and C3, which contain the tyrosine, tryptophan and histidine residues, and tryptophan exists only in these regions, and undergo electrochemical oxidation.	Histidine	169-178	methionine sulfoxide reductase A	Homo sapiens	0-4
23718776-6	2013	Remarkably, His382 is mainly conserved across other members of the EGR family, implying that histidine protonation-deprotonation may serve as a molecular switch for modulating the protein-DNA interactions that are central to this family of transcription factors.	Histidine	93-102	early growth response 1	Homo sapiens	67-70
23097400-11	2013	Arginine, His, and Leu are examples of AA that can promote insulin secretion, and in turn, insulin can increase fetal IGF-I concentrations.	Histidine	10-13	LOC105613195	Ovis aries	59-66
8937558-5	1996	In this enzyme, autophosphorylation of active site histidine is an accepted intermediate step in the catalytic phosphate transfer activity of nucleoside diphosphate kinase (NDP kinase).	Histidine	51-60	cytidine/uridine monophosphate kinase 2	Homo sapiens	142-171
8937558-5	1996	In this enzyme, autophosphorylation of active site histidine is an accepted intermediate step in the catalytic phosphate transfer activity of nucleoside diphosphate kinase (NDP kinase).	Histidine	51-60	cytidine/uridine monophosphate kinase 2	Homo sapiens	173-183
23758282-1	2013	While its biological function remains unclear, the three-cysteine, one-histidine ligated human [2Fe-2S] cluster containing protein mitoNEET is of interest because of its interaction with the anti-diabetes drug pioglitazone.	Histidine	71-80	CDGSH iron sulfur domain 1	Homo sapiens	131-139
8855949-1	1996	We have reported that H93C human myoglobin (Mb), in which proximal histidine (His93, F8) was replaced by cysteine, gave nearly identical spectroscopic features of P-450 [Adachi, S., Nagano, S., Ishimori, K., Watanabe, Y., Morishima, I., Egawa, T., Kitagawa, T., &amp; Makino R. (1993) Biochemistry 32, 241-252].	Histidine	67-76	myoglobin	Homo sapiens	33-42
8816462-2	1996	In the yeast Saccharomyces cerevisiae, the Upf1 protein (Upf1p), which contains a cysteine- and histidine-rich region and nucleoside triphosphate hydrolysis and helicase motifs, was shown to be a trans-acting factor in this decay pathway.	Histidine	96-105	ATP-dependent RNA helicase NAM7	Saccharomyces cerevisiae S288C	43-47
8816462-2	1996	In the yeast Saccharomyces cerevisiae, the Upf1 protein (Upf1p), which contains a cysteine- and histidine-rich region and nucleoside triphosphate hydrolysis and helicase motifs, was shown to be a trans-acting factor in this decay pathway.	Histidine	96-105	ATP-dependent RNA helicase NAM7	Saccharomyces cerevisiae S288C	57-62
8816462-11	1996	In this report, we describe the identification and biochemical characterization of mutations in the amino-terminal cysteine- and histidine-rich region of Upf1p that have normal nonsense-mediated mRNA decay activities but are able to suppress leu2-2 and tyr7-1 nonsense alleles.	Histidine	129-138	ATP-dependent RNA helicase NAM7	Saccharomyces cerevisiae S288C	154-159
8816462-14	1996	Mutations in the cysteine- and histidine-rich region of Upf1p abolish Upf1p-Upf2p interaction.	Histidine	31-40	ATP-dependent RNA helicase NAM7	Saccharomyces cerevisiae S288C	56-61
8816462-14	1996	Mutations in the cysteine- and histidine-rich region of Upf1p abolish Upf1p-Upf2p interaction.	Histidine	31-40	ATP-dependent RNA helicase NAM7	Saccharomyces cerevisiae S288C	70-75
23249163-1	2013	We report the functional analysis of an artificial hexacoordinate oxygen transport protein, HP7, which operates via a mechanism similar to that of human neuroglobin and cytoglobin: the destabilization of one of two heme-ligating histidine residues.	Histidine	229-238	neuroglobin	Homo sapiens	153-164
23469063-8	2013	Chimeras between NL4-3 and LAI Vif identify the amino acid responsible for the differential degradation activity: A histidine at position 48 in Vif confers activity against A3H-hapII, while an asparagine abolishes its anti-A3H activity.	Histidine	116-125	Vif	Human immunodeficiency virus 1	31-34
23469063-8	2013	Chimeras between NL4-3 and LAI Vif identify the amino acid responsible for the differential degradation activity: A histidine at position 48 in Vif confers activity against A3H-hapII, while an asparagine abolishes its anti-A3H activity.	Histidine	116-125	Vif	Human immunodeficiency virus 1	144-147
8843163-0	1996	Identification of the histidine residues involved in substrate recognition by a rat H+/peptide cotransporter, PEPT1.	Histidine	22-31	solute carrier family 15 member 1	Rattus norvegicus	110-115
8843163-4	1996	When expressed in Xenopus oocytes, replacement of either histidine 57 or histidine 121 of the rat PEPT1 with glutamine by site-directed mutagenesis eliminated ceftibuten and [14C]glycylsarcosine transport activities.	Histidine	57-66	solute carrier family 15 member 1	Rattus norvegicus	98-103
23758282-2	2013	The mitoNEET [2Fe-2S] cluster demonstrates proton-coupled electron transfer (PCET) and marked cluster instability, which have both been linked to the single His ligand.	Histidine	157-160	CDGSH iron sulfur domain 1	Homo sapiens	4-12
23541716-8	2013	Additionally, three novel PTMs in ITIH3 were identified and include hexose-N-acetyl-hexosamine at asparagine-(41), trimethylation at aspartic acid-(290), and flavin adenine dinucleotide at histidine-(335).	Histidine	189-198	inter-alpha-trypsin inhibitor heavy chain 3	Homo sapiens	34-39
8843163-4	1996	When expressed in Xenopus oocytes, replacement of either histidine 57 or histidine 121 of the rat PEPT1 with glutamine by site-directed mutagenesis eliminated ceftibuten and [14C]glycylsarcosine transport activities.	Histidine	73-82	solute carrier family 15 member 1	Rattus norvegicus	98-103
8798433-4	1996	The murine Cux-2 homeobox was similar to Drosophila cut and encoded a homeodomain that contained a characteristic histidine residue at position 50.	Histidine	114-123	cut-like homeobox 2	Mus musculus	11-16
22959971-0	2012	Mechanistic studies of the role of a conserved histidine in a mammalian polyamine oxidase.	Histidine	47-56	polyamine oxidase	Homo sapiens	72-89
22959971-2	2012	While no structure has been reported for a mammalian polyamine oxidase, sequence alignments of polyamine oxidizing flavoproteins identify a conserved histidine residue.	Histidine	150-159	polyamine oxidase	Homo sapiens	53-70
22959971-4	2012	The corresponding histidine in mouse polyamine oxidase, His64, has been mutated to glutamine, asparagine, and alanine to determine if this residue plays a similar role in the mammalian enzymes.	Histidine	18-27	polyamine oxidase	Saccharomyces cerevisiae S288C	37-54
23905201-2	2010	The mutated residue in IDH1 is most commonly arginine 132, which is most often replaced with either histidine or cysteine.	Histidine	100-109	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	23-27
23012369-9	2012	In this study, we explored the development of appetite-reducing peptides by synthesizing MC4R agonists based on the insertion of the His-Phe-Arg-Trp sequence into the cyclotide kalata B1.	Histidine	133-136	melanocortin 4 receptor	Homo sapiens	89-93
8877818-2	1996	The amplification was achieved using two primers which correspond to TRH progenitor sequence (Lys/Arg-Arg-Gln-His-Pro-Gly-Lys/Arg-Arg).	Histidine	110-113	thyrotropin-releasing hormone L homeolog	Xenopus laevis	69-72
23480710-3	2013	In the present study, HisbFGF4, a 6x histidine-tagged bovine FGF4 (Pro(32) -Leu(206) ), was produced in Escherichia coli based on the validated nucleotide sequence and purified by heparin column chromatography.	Histidine	37-46	fibroblast growth factor 4	Bos taurus	26-30
8760503-8	1996	(1) A highly conserved histidine residue in the first complementarity-determining region of the TcR beta chain (beta:CDR1) points outward and interacts with highly conserved side-chains on the MHC alpha 2 helix.	Histidine	23-32	T cell receptor alpha variable 6-3	Mus musculus	96-99
8863155-1	1996	In five different Japanese families, we identified six male hemizygotes (aged 6, 9, 15, 17, 56, and 65 years) and a putative candidate (aged 48 years), carrying a mutant allele of the ornithine transcarbamylase (OTC) gene, a G to A substitution at nucleotide 119 in exon 2 generating histidine in place of arginine.	Histidine	284-293	ornithine transcarbamylase	Homo sapiens	212-215
23134726-2	2012	We used single histidine (H) substitutions of these charged residues in the Na(v)1.4 channel to probe the positions of the S4 segments at hyperpolarized potentials.	Histidine	15-24	immunoglobulin lambda variable 2-14	Homo sapiens	76-84
23677194-9	2012	The genetic study identified a homozygous mutation of the MUTYH gene, called c.340T &gt; C, that produces an amino acid change of tyrosine for histidine called p.Y114H.	Histidine	143-152	mutY DNA glycosylase	Homo sapiens	58-63
23231502-5	2013	Incubation of purified Pin1 with HNE followed by MALDI-TOF/TOF mass spectrometry resulted in detection of Michael adducts at the active site residues His-157 and Cys-113.	Histidine	150-153	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	23-27
22957700-11	2012	Magnetic circular dichroism, resonance Raman, and electron paramagnetic resonance spectroscopic data on the ferric, ferrous, and ferrous-CO complexes of GAPDH showed that the heme is bis-ligated with His as the proximal ligand.	Histidine	200-203	glyceraldehyde-3-phosphate dehydrogenase	Oryctolagus cuniculus	153-158
8661426-6	1996	When the catalytically inactive, histidine-tagged mutant PKR protein [His-PKR(K296R)] was examined as a substrate for purified wild-type PKR, the intermolecular phosphorylation of His-PKR(K296R) was efficiently catalyzed by dsRNA-activated PKR but not by heparin-activated PKR.	Histidine	33-42	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	57-60
8661426-6	1996	When the catalytically inactive, histidine-tagged mutant PKR protein [His-PKR(K296R)] was examined as a substrate for purified wild-type PKR, the intermolecular phosphorylation of His-PKR(K296R) was efficiently catalyzed by dsRNA-activated PKR but not by heparin-activated PKR.	Histidine	33-42	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	74-77
8661426-6	1996	When the catalytically inactive, histidine-tagged mutant PKR protein [His-PKR(K296R)] was examined as a substrate for purified wild-type PKR, the intermolecular phosphorylation of His-PKR(K296R) was efficiently catalyzed by dsRNA-activated PKR but not by heparin-activated PKR.	Histidine	33-42	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	74-77
8661426-6	1996	When the catalytically inactive, histidine-tagged mutant PKR protein [His-PKR(K296R)] was examined as a substrate for purified wild-type PKR, the intermolecular phosphorylation of His-PKR(K296R) was efficiently catalyzed by dsRNA-activated PKR but not by heparin-activated PKR.	Histidine	33-42	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	74-77
8661426-6	1996	When the catalytically inactive, histidine-tagged mutant PKR protein [His-PKR(K296R)] was examined as a substrate for purified wild-type PKR, the intermolecular phosphorylation of His-PKR(K296R) was efficiently catalyzed by dsRNA-activated PKR but not by heparin-activated PKR.	Histidine	33-42	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	74-77
8661426-6	1996	When the catalytically inactive, histidine-tagged mutant PKR protein [His-PKR(K296R)] was examined as a substrate for purified wild-type PKR, the intermolecular phosphorylation of His-PKR(K296R) was efficiently catalyzed by dsRNA-activated PKR but not by heparin-activated PKR.	Histidine	33-42	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	74-77
8661426-6	1996	When the catalytically inactive, histidine-tagged mutant PKR protein [His-PKR(K296R)] was examined as a substrate for purified wild-type PKR, the intermolecular phosphorylation of His-PKR(K296R) was efficiently catalyzed by dsRNA-activated PKR but not by heparin-activated PKR.	Histidine	70-73	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	57-60
8661426-6	1996	When the catalytically inactive, histidine-tagged mutant PKR protein [His-PKR(K296R)] was examined as a substrate for purified wild-type PKR, the intermolecular phosphorylation of His-PKR(K296R) was efficiently catalyzed by dsRNA-activated PKR but not by heparin-activated PKR.	Histidine	70-73	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	74-77
8661426-6	1996	When the catalytically inactive, histidine-tagged mutant PKR protein [His-PKR(K296R)] was examined as a substrate for purified wild-type PKR, the intermolecular phosphorylation of His-PKR(K296R) was efficiently catalyzed by dsRNA-activated PKR but not by heparin-activated PKR.	Histidine	70-73	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	74-77
22766396-0	2012	The histidine-loop is essential for transport activity of human MDR3.	Histidine	4-13	ATP binding cassette subfamily B member 4	Homo sapiens	64-68
22766396-3	2012	Here we report the first patient with a mutation of the putative histidine-loop of a human ABC transporter, the multi drug resistance protein 3 (MDR3).	Histidine	65-74	ATP binding cassette subfamily B member 4	Homo sapiens	112-143
22766396-3	2012	Here we report the first patient with a mutation of the putative histidine-loop of a human ABC transporter, the multi drug resistance protein 3 (MDR3).	Histidine	65-74	ATP binding cassette subfamily B member 4	Homo sapiens	145-149
22766396-7	2012	As shown by sequence alignment, this amino acid corresponds to the highly conserved histidine of the "H-loop", which is critical for ATP-hydrolysis, suggesting an essential role of histidine 1231 of human MDR3.	Histidine	84-93	ATP binding cassette subfamily B member 4	Homo sapiens	205-209
22766396-7	2012	As shown by sequence alignment, this amino acid corresponds to the highly conserved histidine of the "H-loop", which is critical for ATP-hydrolysis, suggesting an essential role of histidine 1231 of human MDR3.	Histidine	181-190	ATP binding cassette subfamily B member 4	Homo sapiens	205-209
23283979-7	2013	These data suggest that Cys-373 and His-880 in Na(V)1.5 are proton sensors for use-dependent and slow inactivation and have implications in isoform-specific modulation of Na(V) channels.	Histidine	36-39	immunoglobulin lambda variable 2-18	Homo sapiens	47-55
22740564-11	2012	Rapid and complete disassembly of the T-cell surface-bound A02/CMV Histamer followed by the subsequent dissociation of the pMHC monomers from CD8(+) CTL receptors was achieved using 100 mM L-histidine.	Histidine	189-200	CD8a molecule	Homo sapiens	142-145
8661426-6	1996	When the catalytically inactive, histidine-tagged mutant PKR protein [His-PKR(K296R)] was examined as a substrate for purified wild-type PKR, the intermolecular phosphorylation of His-PKR(K296R) was efficiently catalyzed by dsRNA-activated PKR but not by heparin-activated PKR.	Histidine	70-73	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	74-77
8661426-6	1996	When the catalytically inactive, histidine-tagged mutant PKR protein [His-PKR(K296R)] was examined as a substrate for purified wild-type PKR, the intermolecular phosphorylation of His-PKR(K296R) was efficiently catalyzed by dsRNA-activated PKR but not by heparin-activated PKR.	Histidine	70-73	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	74-77
8661426-6	1996	When the catalytically inactive, histidine-tagged mutant PKR protein [His-PKR(K296R)] was examined as a substrate for purified wild-type PKR, the intermolecular phosphorylation of His-PKR(K296R) was efficiently catalyzed by dsRNA-activated PKR but not by heparin-activated PKR.	Histidine	70-73	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	74-77
8661426-6	1996	When the catalytically inactive, histidine-tagged mutant PKR protein [His-PKR(K296R)] was examined as a substrate for purified wild-type PKR, the intermolecular phosphorylation of His-PKR(K296R) was efficiently catalyzed by dsRNA-activated PKR but not by heparin-activated PKR.	Histidine	180-183	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	57-60
8661426-6	1996	When the catalytically inactive, histidine-tagged mutant PKR protein [His-PKR(K296R)] was examined as a substrate for purified wild-type PKR, the intermolecular phosphorylation of His-PKR(K296R) was efficiently catalyzed by dsRNA-activated PKR but not by heparin-activated PKR.	Histidine	180-183	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	74-77
8661426-6	1996	When the catalytically inactive, histidine-tagged mutant PKR protein [His-PKR(K296R)] was examined as a substrate for purified wild-type PKR, the intermolecular phosphorylation of His-PKR(K296R) was efficiently catalyzed by dsRNA-activated PKR but not by heparin-activated PKR.	Histidine	180-183	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	74-77
8661426-6	1996	When the catalytically inactive, histidine-tagged mutant PKR protein [His-PKR(K296R)] was examined as a substrate for purified wild-type PKR, the intermolecular phosphorylation of His-PKR(K296R) was efficiently catalyzed by dsRNA-activated PKR but not by heparin-activated PKR.	Histidine	180-183	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	74-77
23070920-7	2013	The cDNA cloned was expressed in Escherichia coli, which indicated that POLR2H fusion with the N-terminally His-tagged form brought about the accumulation of an expected 20.5 kDa polypeptide in line with the predicted protein.	Histidine	108-111	DNA-directed RNA polymerases I, II, and III subunit RPABC3	Ailuropoda melanoleuca	72-78
8661426-6	1996	When the catalytically inactive, histidine-tagged mutant PKR protein [His-PKR(K296R)] was examined as a substrate for purified wild-type PKR, the intermolecular phosphorylation of His-PKR(K296R) was efficiently catalyzed by dsRNA-activated PKR but not by heparin-activated PKR.	Histidine	180-183	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	74-77
8661426-6	1996	When the catalytically inactive, histidine-tagged mutant PKR protein [His-PKR(K296R)] was examined as a substrate for purified wild-type PKR, the intermolecular phosphorylation of His-PKR(K296R) was efficiently catalyzed by dsRNA-activated PKR but not by heparin-activated PKR.	Histidine	180-183	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	74-77
8766941-1	1996	A clinical, prospective experiment was carried out to determine whether long-term intranasal administration of the growth hormone-releasing peptide hexarelin (His-D-2-methyl-Trp-Ala-Trp-D-Phe -Lys-NH2) affects pituitary growth hormone secretion.	Histidine	159-162	ghrelin and obestatin prepropeptide	Homo sapiens	115-147
22577880-2	2012	Copper-ATPase ATP7A is unique in having a sequence rich in histidine and methionine residues located on the lumenal side of the membrane.	Histidine	59-68	ATPase copper transporting alpha	Homo sapiens	14-19
22458729-3	2012	Spectroscopic characterization of CymA from Shewanella oneidensis strain MR-1 identifies three low-spin His/His co-ordinated c-haems and a single high-spin c-haem with His/H(2)O co-ordination lying adjacent to the quinol-binding site.	Histidine	104-107	cytochrome c	Shewanella oneidensis MR-1	34-38
22458729-3	2012	Spectroscopic characterization of CymA from Shewanella oneidensis strain MR-1 identifies three low-spin His/His co-ordinated c-haems and a single high-spin c-haem with His/H(2)O co-ordination lying adjacent to the quinol-binding site.	Histidine	108-111	cytochrome c	Shewanella oneidensis MR-1	34-38
22458729-3	2012	Spectroscopic characterization of CymA from Shewanella oneidensis strain MR-1 identifies three low-spin His/His co-ordinated c-haems and a single high-spin c-haem with His/H(2)O co-ordination lying adjacent to the quinol-binding site.	Histidine	108-111	cytochrome c	Shewanella oneidensis MR-1	34-38
23046410-7	2013	On the basis of structural modelling and comparison, as well as large-scale sequence alignment studies, we further determined that the catalytic mechanism of Cg1458 is actually through a glutamic acid-histidine-water triad, and this catalytic triad is common among FAH family proteins that catalyse the cleavage of the C-C bond of the substrate.	Histidine	201-210	fumarylacetoacetate hydrolase	Homo sapiens	265-268
22561016-3	2012	The over-expressed protein was identified with mOCTN3 by anti-His antibody and reconstitution in liposomes.	Histidine	62-65	solute carrier family 22 (organic cation transporter), member 21	Mus musculus	47-53
8626468-11	1996	2) Substitution of either His residue in HEXXH leads to apparent intracellular degradation of the mutant products, pointing to a role for zinc binding in in vivo stability of gp63.	Histidine	26-29	leishmanolysin like peptidase	Homo sapiens	175-179
23653868-6	2013	The most informative results were obtained with the exon 4 flanking primers and the Cac8I restriction enzyme, which generated a 253 bp product that carries the ACVR1 617G&gt;A mutation, which causes an amino acid substitution of histidine for arginine at position 206 of the glycine-serine (GS) domain, and its mutation results in the dysregulation of bone morphogenetic protein (BMP) signalling that causes FOP.	Histidine	229-238	bone morphogenetic protein 1	Homo sapiens	352-378
8824716-3	1995	The corresponding cDNA coding for the human alpha-enolase was isolated from a human endometrial cDNA library and cloned into the vector pH6EX3, allowing the efficient expression of recombinant human alpha-enolase with an N-terminal histidine-hexapeptide as affinity ligand in Escherichia coli.	Histidine	232-241	enolase 1	Homo sapiens	44-57
8824716-3	1995	The corresponding cDNA coding for the human alpha-enolase was isolated from a human endometrial cDNA library and cloned into the vector pH6EX3, allowing the efficient expression of recombinant human alpha-enolase with an N-terminal histidine-hexapeptide as affinity ligand in Escherichia coli.	Histidine	232-241	enolase 1	Homo sapiens	199-212
22506810-1	2012	The Arabidopsis thaliana At1g68290 gene encoding an endonuclease was isolated and designated ENDO2, which was cloned into a binary vector to overexpress ENDO2 with a C-terminal 6 x His-tag in A. thaliana.	Histidine	181-184	endonuclease 2	Arabidopsis thaliana	93-98
22506810-1	2012	The Arabidopsis thaliana At1g68290 gene encoding an endonuclease was isolated and designated ENDO2, which was cloned into a binary vector to overexpress ENDO2 with a C-terminal 6 x His-tag in A. thaliana.	Histidine	181-184	endonuclease 2	Arabidopsis thaliana	153-158
23653868-6	2013	The most informative results were obtained with the exon 4 flanking primers and the Cac8I restriction enzyme, which generated a 253 bp product that carries the ACVR1 617G&gt;A mutation, which causes an amino acid substitution of histidine for arginine at position 206 of the glycine-serine (GS) domain, and its mutation results in the dysregulation of bone morphogenetic protein (BMP) signalling that causes FOP.	Histidine	229-238	bone morphogenetic protein 1	Homo sapiens	380-383
23648677-8	2013	Moreover, the UGT2B15*2 mutation significantly increased the Km value of sipoglitazar in the kinetic analysis using recombinant His-tag UGT2B15*1- or *2-membrane fractions.	Histidine	128-131	UDP glucuronosyltransferase family 2 member B15	Homo sapiens	14-21
22612077-8	2012	In our calculation on the special pair radical cation, we show that the coordinating histidine residues reduce the spin-density asymmetry between the two halves of this system, while inclusion of a larger binding pocket model increases this asymmetry.	Histidine	85-94	spindlin 1	Homo sapiens	115-119
8749247-7	1995	The IgG molecules were found to adsorb on membrane immobilized histidine via their Fab part.	Histidine	63-72	FA complementation group B	Homo sapiens	83-86
22419824-10	2012	The absorption spectrum of the reconstituted BoWSCP-His was identical to that of the native BoWSCP.	Histidine	52-55	kunitz-type trypsin inhibitor-like 1 protein	Brassica oleracea	45-51
23648677-8	2013	Moreover, the UGT2B15*2 mutation significantly increased the Km value of sipoglitazar in the kinetic analysis using recombinant His-tag UGT2B15*1- or *2-membrane fractions.	Histidine	128-131	UDP glucuronosyltransferase family 2 member B15	Homo sapiens	136-143
22419824-10	2012	The absorption spectrum of the reconstituted BoWSCP-His was identical to that of the native BoWSCP.	Histidine	52-55	kunitz-type trypsin inhibitor-like 1 protein	Brassica oleracea	92-98
23405232-4	2013	Previous studies have shown that SEB stimulates a more potent activation of T lymphocytes than SEC3, and mutations of the histidine residues eliminated the toxicity of SEB.	Histidine	122-131	seborrheic dermatitis	Mus musculus	168-171
22419824-11	2012	Chl binding analyses of BoWSCP-His revealed that the BoWSCP-His bound both Chl a and Chl b with almost the same affinity in 40% methanol solution, although the native BoWSCP had a higher content of Chl a.	Histidine	31-34	kunitz-type trypsin inhibitor-like 1 protein	Brassica oleracea	24-30
22419824-11	2012	Chl binding analyses of BoWSCP-His revealed that the BoWSCP-His bound both Chl a and Chl b with almost the same affinity in 40% methanol solution, although the native BoWSCP had a higher content of Chl a.	Histidine	31-34	kunitz-type trypsin inhibitor-like 1 protein	Brassica oleracea	53-59
22419824-11	2012	Chl binding analyses of BoWSCP-His revealed that the BoWSCP-His bound both Chl a and Chl b with almost the same affinity in 40% methanol solution, although the native BoWSCP had a higher content of Chl a.	Histidine	31-34	kunitz-type trypsin inhibitor-like 1 protein	Brassica oleracea	53-59
7490766-6	1995	We present a molecular model of the c-Myc-Max heterostranded coiled-coil describing potential electrostatic interactions responsible for the specificity of the interaction, the main feature being putative buried electrostatic interactions between a histidine side-chain (in the Max leucine zipper) and two glutamic acid side-chains (in the c-Myc leucine zipper) at the heterodimer interface.	Histidine	249-258	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	36-41
7490766-8	1995	This indicates that the charged histidine side-chain contributes approximately 0.57 (+/- 0.07) kcal/mol (2.38 (+/- 0.30) kJ/mol) of stabilization free energy to the c-Myc-Max heterostranded coiled-coil through favorable electrostatic interaction.	Histidine	32-41	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	165-170
8633765-0	1995	Structural study of electrolysis-induced degradation of the growth hormone releasing peptide His-D-Trp-Ala-Trp-D-Phe-Lys-NH2.	Histidine	93-96	ghrelin and obestatin prepropeptide	Homo sapiens	60-92
22981363-3	2012	The equivalent position in UGT1A4 is also known to influence enzyme activity, whilst an N-terminal domain histidine (His37 in UGT1A9) is believed to function as the catalytic base in most UGT enzymes.	Histidine	106-115	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	27-33
8633765-1	1995	Growth hormone releasing peptide (GHRP, sequence His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) is a synthetic hexapeptide under consideration for transdermal iontophoretic drug delivery.	Histidine	49-52	ghrelin and obestatin prepropeptide	Homo sapiens	0-32
8633765-1	1995	Growth hormone releasing peptide (GHRP, sequence His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) is a synthetic hexapeptide under consideration for transdermal iontophoretic drug delivery.	Histidine	49-52	ghrelin and obestatin prepropeptide	Homo sapiens	34-38
22278351-0	2012	In vivo imaging of radiation-induced tissue apoptosis by (99m)Tc(I)-his          (6)-annexin A5.	Histidine	68-71	annexin A5	Mus musculus	85-95
22278351-1	2012	OBJECTIVE: A recombinant annexin A5 with the N-terminal extension of six histidine residues was labeled with (99m)Tc(I)-tricarbonyl ion to produce the (99m)Tc-labeled annexin A5, referred to (99m)Tc(I)-his(6)-annexin A5.	Histidine	73-82	annexin A5	Mus musculus	25-35
23021866-6	2012	Two SNPs were associated with BV as diagnosed by the Nugent score and the combined criteria: a minor allele G of rs4986790 (frequency=0.07), which encodes a His to Tyr substitution in TLR4 (HR=1.47, 95% CI 1.15-1.87) and rs187084 (frequency=0.24) on TLR9.	Histidine	157-160	toll like receptor 4	Homo sapiens	184-188
22240035-0	2012	Distinct roles in folding, CD81 receptor binding and viral entry for conserved histidine residues of hepatitis C virus glycoprotein E1 and E2.	Histidine	79-88	CD81 molecule	Homo sapiens	27-31
23153210-10	2012	Notably, two NPC1 haplotypes were also associated with T2D in men (rs1805081-rs1788799, His-Met: P = 0.0012, OR = 1.54; His-Ile: P = 0.0004, OR = 0.63).	Histidine	88-91	NPC intracellular cholesterol transporter 1	Homo sapiens	13-17
22306030-9	2012	Taken together, these observations are consistent with an important role that neuronal HIS may play in mediating the potent effects of AMN+LEP on food intake and body weight.	Histidine	87-90	amnion associated transmembrane protein	Rattus norvegicus	135-142
7492589-1	1995	A resonance Raman spectroscopic study of the porcine myoglobin double mutant H64V/V68H has confirmed that the ferric form is bis-histidine ligated, has revealed that the bis-histidine ligation is retained on reduction to the ferrous form, and has demonstrated that CO can displace the ligated distal histidine to produce a ferrous CO form which has a low steady-state photolability, indicating that the replacement histidine blocks the CO escape route from the binding site.	Histidine	129-138	myoglobin	Homo sapiens	53-62
7492589-1	1995	A resonance Raman spectroscopic study of the porcine myoglobin double mutant H64V/V68H has confirmed that the ferric form is bis-histidine ligated, has revealed that the bis-histidine ligation is retained on reduction to the ferrous form, and has demonstrated that CO can displace the ligated distal histidine to produce a ferrous CO form which has a low steady-state photolability, indicating that the replacement histidine blocks the CO escape route from the binding site.	Histidine	174-183	myoglobin	Homo sapiens	53-62
23153210-10	2012	Notably, two NPC1 haplotypes were also associated with T2D in men (rs1805081-rs1788799, His-Met: P = 0.0012, OR = 1.54; His-Ile: P = 0.0004, OR = 0.63).	Histidine	120-123	NPC intracellular cholesterol transporter 1	Homo sapiens	13-17
8594998-2	1995	Oxidation of the C-2 position of the imidazole ring of histidine converts the residue to 2-oxohistidine, a novel amino acid which may serve as a marker of oxidative modification of proteins (K. Uchida and S. Kawakishi, J. Biol.	Histidine	55-64	complement C2	Homo sapiens	17-20
22955034-7	2012	Deduced amino acid sequences of two putative genes showed that VlFAD2s show high similarity to Arabidopsis FAD2 and commonly contain six transmembrane domain, three histidine boxes and endoplasmic reticulum (ER) retrieval motif representing the characteristics of fatty acid desaturase.	Histidine	165-174	fatty acid desaturase 2	Arabidopsis thaliana	65-69
7541849-4	1995	Excess His-PKR(K296R) substrate inhibited both the auto- and the trans-phosphorylation activities of PKR(Wt).	Histidine	7-10	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	101-108
7543025-0	1995	Histidine phosphorylation of P-selectin upon stimulation of human platelets: a novel pathway for activation-dependent signal transduction.	Histidine	0-9	selectin P	Homo sapiens	29-39
7543025-4	1995	We now establish that phosphorylation following platelet activation with thrombin or collagen generates phosphohistidine at histidines on the cytoplasmic tail of P-selectin.	Histidine	124-134	selectin P	Homo sapiens	162-172
22437718-1	2012	The enzyme tyrosinase contains two Cu(I) centres, trigonally coordinated by imidazole nitrogens of six conserved histidine residues.	Histidine	113-122	tyrosinase	Homo sapiens	11-21
22185821-2	2012	Given the existence of a tight interplay of the Nrf2/NF-kappaB systems and that the pro-inflammatory response is governed by transcription factor NF-kappaB, here we sought to investigate whether and how cyclo(His-Pro) interferes with the cross-talk between the antioxidant Nrf2/heme oxygenase-1 and the pro-inflammatory NF-kappaB pathways.	Histidine	209-212	heme oxygenase 1	Rattus norvegicus	278-294
22185821-3	2012	By knocking down the Nrf2 gene, we confirmed that cyclo(His-Pro) inhibits NF-kappaB nuclear accumulation induced by paraquat in rat pheochromocytoma PC12 cells via the Nrf2/heme oxygenase-1 pathway.	Histidine	56-59	heme oxygenase 1	Rattus norvegicus	173-189
21895720-7	2012	RESULTS: The ADH1B 47Arg allele was found to be associated with increased risk of UADT cancers, the pooled odds ratios (ORs) being 1.66 (95% CI: 1.54 to 1.79) and 3.47 (95% CI: 2.76 to 4.36) for the His/Arg and Arg/Arg genotypes compared with the His/His genotype, respectively.	Histidine	199-202	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	13-18
21895720-7	2012	RESULTS: The ADH1B 47Arg allele was found to be associated with increased risk of UADT cancers, the pooled odds ratios (ORs) being 1.66 (95% CI: 1.54 to 1.79) and 3.47 (95% CI: 2.76 to 4.36) for the His/Arg and Arg/Arg genotypes compared with the His/His genotype, respectively.	Histidine	247-250	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	13-18
21895720-7	2012	RESULTS: The ADH1B 47Arg allele was found to be associated with increased risk of UADT cancers, the pooled odds ratios (ORs) being 1.66 (95% CI: 1.54 to 1.79) and 3.47 (95% CI: 2.76 to 4.36) for the His/Arg and Arg/Arg genotypes compared with the His/His genotype, respectively.	Histidine	247-250	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	13-18
22890884-7	2012	Reciprocal immunoprecipitation of EcR-B1-containing complexes from Bm5 cells transfected with control pIZT/V5-His vector and treated with 20E showed that EcR-B1 bound to USP in the absence of 30K but did not bind to USP in pIZT/30K/V5-His-transfected Bm5 cells.	Histidine	235-238	protein ultraspiracle homolog	Bombyx mori	170-173
7769716-5	1995	An absolutely conserved histidine in CD2 has also been demonstrated by site-directed mutagenesis of the SCMV and HSV-1 enzymes to be essential for proteolytic activity and has been proposed to be a second member of the catalytic triad of this serine proteinase.	Histidine	24-33	CD2 molecule	Homo sapiens	37-40
22730687-5	2012	The frequency (6.7%) of XRCC1-280 His/His in case group was significantly higher than that (4.3%) in control group (P &lt; 0.05), OR for lung cancer was 2.46 (95% CI: 1.141-5.304).	Histidine	34-37	X-ray repair cross complementing 1	Homo sapiens	24-29
22743102-7	2012	Sequence analyses establish that while both PRO(FUR) and PRO(PC1) are enriched in histidines when compared with cognate catalytic domains and prokaryotic orthologs, histidine content in PRO(FUR) is ~2-fold greater than that in PRO(PC1), which may augment its pH sensitivity.	Histidine	82-92	proprotein convertase subtilisin/kexin type 1	Homo sapiens	61-64
22730687-5	2012	The frequency (6.7%) of XRCC1-280 His/His in case group was significantly higher than that (4.3%) in control group (P &lt; 0.05), OR for lung cancer was 2.46 (95% CI: 1.141-5.304).	Histidine	38-41	X-ray repair cross complementing 1	Homo sapiens	24-29
22730687-8	2012	The risks of lung cancer in smokers with XRCC1-194 Arg/Trp+Trp/Trp and XRCC1-280 His/His+Arg/His were 4.889 (95% CI: 2.828-8.452) and 6.281(95% CI: 3.572-11.046), respectively.	Histidine	81-84	X-ray repair cross complementing 1	Homo sapiens	71-76
7769858-2	1995	The antagonist was generated by alkylation to inactivate catalytic His-residues of native human interleukin-3.	Histidine	67-70	interleukin 3	Homo sapiens	96-109
22743102-7	2012	Sequence analyses establish that while both PRO(FUR) and PRO(PC1) are enriched in histidines when compared with cognate catalytic domains and prokaryotic orthologs, histidine content in PRO(FUR) is ~2-fold greater than that in PRO(PC1), which may augment its pH sensitivity.	Histidine	82-91	proprotein convertase subtilisin/kexin type 1	Homo sapiens	61-64
21965683-2	2011	Most of the neuroglobin is present in a hexacoordinate state with proximal and distal histidines in the heme pocket directly bound to the heme iron.	Histidine	86-96	neuroglobin	Homo sapiens	12-23
22930753-9	2012	Our results suggest that external Zn(2+) regulates ENaC activity by binding to multiple extracellular sites within the gamma-subunit, including (i) a high-affinity stimulatory site within the finger subdomain involving His(193), His(200), and His(202) and (ii) a low-affinity Zn(2+) inhibitory site within the palm subdomain that includes His(88) and Asp(516).	Histidine	219-222	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	51-55
21956104-1	2011	In the Saccharomyces cerevisiae actin-profilin interface, Ala(167) of the actin barbed end W-loop and His(372) near the C terminus form a clamp around a profilin segment containing residue Arg(81) and Tyr(79).	Histidine	102-105	profilin	Saccharomyces cerevisiae S288C	38-46
21956104-1	2011	In the Saccharomyces cerevisiae actin-profilin interface, Ala(167) of the actin barbed end W-loop and His(372) near the C terminus form a clamp around a profilin segment containing residue Arg(81) and Tyr(79).	Histidine	102-105	profilin	Saccharomyces cerevisiae S288C	153-161
22930753-9	2012	Our results suggest that external Zn(2+) regulates ENaC activity by binding to multiple extracellular sites within the gamma-subunit, including (i) a high-affinity stimulatory site within the finger subdomain involving His(193), His(200), and His(202) and (ii) a low-affinity Zn(2+) inhibitory site within the palm subdomain that includes His(88) and Asp(516).	Histidine	229-232	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	51-55
22131323-3	2011	Divalent cations Zn(2+), Cu(2+) and Ni(2+) inhibit Ca(V)3.2 channels more efficiently than Ca(V)3.1 and Ca(V)3.3 channels via second high-affinity binding site including histidine H191 specific for the Ca(V)3.2 channel.	Histidine	170-179	immunoglobulin lambda variable 7-46	Homo sapiens	104-112
7675545-7	1995	PML, whose function is unknown, belongs to a novel family of nuclear proteins characterized by the presence of a Cys/His-rich motif, named a RING finger, that include RNA-binding proteins, transcription factors and oncoproteins.	Histidine	117-120	PML nuclear body scaffold	Homo sapiens	0-3
22907071-2	2012	A genetically introduced His-tag arm stretches out of the central structure of a C(2)-symmetric homodimer of glutathione S-transferase, which is used as a linker to recruit a second building block through interprotein metal coordination, forming self-assembled one-dimensional nanostructures with excellent enzymatic activity.	Histidine	25-28	glutathione S-transferase kappa 1	Homo sapiens	109-134
7867644-6	1995	A comparison between the orientation of the rhombic perturbations and the crystal structures of horse cytochrome c and P. aeruginosa cytochrome c551 reveals that the orientation of the histidine and methionine axial ligands dominates the rhombic perturbation and that the two ligands have approximately equal influence.	Histidine	185-194	cytochrome c, somatic	Equus caballus	102-114
21856016-2	2011	Factor H protein is polymorphic at amino acid 402, in which the resulting histidine containing moiety has been established to impart significant risk of AMD.	Histidine	74-83	complement factor H	Homo sapiens	0-8
22560897-7	2012	AtMRS2-10, which contains an N-terminal His-tag, was expressed in Escherichia coli and solubilized with sarcosyl.	Histidine	40-43	magnesium transporter 1	Arabidopsis thaliana	0-9
21866897-10	2011	Surprisingly, mutant NP2(V24E) turned out to be particularly similar in behavior to sGC; i.e., the Fe(II)-His bond is sensitive to breakage upon NO binding, whereas the unliganded form binds the proximal His at neutral pH.	Histidine	106-109	neuropilin 2	Homo sapiens	21-25
21866897-10	2011	Surprisingly, mutant NP2(V24E) turned out to be particularly similar in behavior to sGC; i.e., the Fe(II)-His bond is sensitive to breakage upon NO binding, whereas the unliganded form binds the proximal His at neutral pH.	Histidine	204-207	neuropilin 2	Homo sapiens	21-25
21866897-11	2011	To the best of our knowledge, NP2(V24E) is the first example in which the ability to use the His-on   His-off switch was engineered into a heme protein by site-directed mutagenesis other than the proximal His itself.	Histidine	93-96	neuropilin 2	Homo sapiens	30-34
21866897-11	2011	To the best of our knowledge, NP2(V24E) is the first example in which the ability to use the His-on   His-off switch was engineered into a heme protein by site-directed mutagenesis other than the proximal His itself.	Histidine	102-105	neuropilin 2	Homo sapiens	30-34
7802655-3	1994	In particular, the long run of consecutive glycines and histidines of delta and YY1 is missing.	Histidine	56-66	YY1 transcription factor L homeolog	Xenopus laevis	80-83
22537104-0	2012	A critical histidine residue within LIMP-2 mediates pH sensitive binding to its ligand beta-glucocerebrosidase.	Histidine	11-20	scavenger receptor class B member 2	Homo sapiens	36-42
7988680-3	1994	At a position corresponding to E170 in PKA most Ser/Thr kinases have an aspartic or glutamic acid, while CK-II has a histidine residue (H160).	Histidine	117-126	casein kinase 2 alpha 1	Homo sapiens	105-110
7524680-0	1994	pH titration of the histidine residues of cyclophilin and FK506 binding protein in the absence and presence of immunosuppressant ligands.	Histidine	20-29	peptidylprolyl isomerase G	Homo sapiens	42-53
7524680-1	1994	Histidine residues in immunophilins, particularly His-126 of cyclophilin (CyP) and His-87 of the FK506 binding protein (FKBP), have been suggested to play important roles in ligand binding and peptidyl prolyl cis-trans isomerase (PPiase) catalysis.	Histidine	0-9	peptidylprolyl isomerase G	Homo sapiens	61-72
7524680-1	1994	Histidine residues in immunophilins, particularly His-126 of cyclophilin (CyP) and His-87 of the FK506 binding protein (FKBP), have been suggested to play important roles in ligand binding and peptidyl prolyl cis-trans isomerase (PPiase) catalysis.	Histidine	0-9	peptidylprolyl isomerase G	Homo sapiens	74-77
7524680-1	1994	Histidine residues in immunophilins, particularly His-126 of cyclophilin (CyP) and His-87 of the FK506 binding protein (FKBP), have been suggested to play important roles in ligand binding and peptidyl prolyl cis-trans isomerase (PPiase) catalysis.	Histidine	0-3	peptidylprolyl isomerase G	Homo sapiens	61-72
21866897-11	2011	To the best of our knowledge, NP2(V24E) is the first example in which the ability to use the His-on   His-off switch was engineered into a heme protein by site-directed mutagenesis other than the proximal His itself.	Histidine	102-105	neuropilin 2	Homo sapiens	30-34
21647637-6	2011	An intron in the 5"-untranslated region and three histidine boxes in the protein, which are characteristic of plant FAD2 genes, have been well-conserved.	Histidine	50-59	omega-6 fatty acid desaturase, endoplasmic reticulum	Brassica rapa	116-120
7524680-1	1994	Histidine residues in immunophilins, particularly His-126 of cyclophilin (CyP) and His-87 of the FK506 binding protein (FKBP), have been suggested to play important roles in ligand binding and peptidyl prolyl cis-trans isomerase (PPiase) catalysis.	Histidine	0-3	peptidylprolyl isomerase G	Homo sapiens	74-77
22537104-0	2012	A critical histidine residue within LIMP-2 mediates pH sensitive binding to its ligand beta-glucocerebrosidase.	Histidine	11-20	glucosylceramidase beta	Homo sapiens	87-110
7524680-1	1994	Histidine residues in immunophilins, particularly His-126 of cyclophilin (CyP) and His-87 of the FK506 binding protein (FKBP), have been suggested to play important roles in ligand binding and peptidyl prolyl cis-trans isomerase (PPiase) catalysis.	Histidine	50-53	peptidylprolyl isomerase G	Homo sapiens	61-72
7524680-1	1994	Histidine residues in immunophilins, particularly His-126 of cyclophilin (CyP) and His-87 of the FK506 binding protein (FKBP), have been suggested to play important roles in ligand binding and peptidyl prolyl cis-trans isomerase (PPiase) catalysis.	Histidine	50-53	peptidylprolyl isomerase G	Homo sapiens	74-77
7524680-2	1994	The charged states of the histidine residues in FKBP and CyP, which were characterized by their pKa values, have been determined in the absence and presence of the immunosuppressant ligands, ascomycin and cyclosporin A (CsA), respectively, by using a heteronuclear two-dimensional NMR method.	Histidine	26-35	peptidylprolyl isomerase G	Homo sapiens	57-60
21536417-2	2011	Turbidity, zeta potential and 1H NMR measurements were used to study the aggregation behaviors of His-PAsp/PAsp under different pH values.	Histidine	98-101	carboxypeptidase B1	Homo sapiens	102-106
21536417-2	2011	Turbidity, zeta potential and 1H NMR measurements were used to study the aggregation behaviors of His-PAsp/PAsp under different pH values.	Histidine	98-101	carboxypeptidase B1	Homo sapiens	107-111
22537104-4	2012	Moreover, we identified a single histidine residue in LIMP-2 that is necessary for LIMP-2 and GC binding.	Histidine	33-42	scavenger receptor class B member 2	Homo sapiens	54-60
21646353-4	2011	We demonstrate that the characteristic His/Met-rich segment Met(672)-Pro(707) (HM-loop) that connects the first two transmembrane segments of ATP7A is important for copper release.	Histidine	39-42	ATPase copper transporting alpha	Homo sapiens	142-147
22537104-4	2012	Moreover, we identified a single histidine residue in LIMP-2 that is necessary for LIMP-2 and GC binding.	Histidine	33-42	scavenger receptor class B member 2	Homo sapiens	83-89
22520078-10	2012	Individual mutations at diverse sites within AtMTP1 conferred Co and Cd tolerance in yeast, and included deletions in N-terminal and His-rich intra-molecular cytosolic domains, and mutations of single residues flanking the transmembrane pore or participating in intra- or inter-molecular domain interactions, all of which are not conserved in the non-selective EcYiiP.	Histidine	133-136	zinc transporter	Arabidopsis thaliana	45-51
21602277-7	2011	Reciprocal mutation of His(995) in the hTRPM2 channel and the equivalent Gln(992) in the mTRPM2 channel completely swapped the kinetics, but no such opposing effects resulted from exchanging another pair of species-specific residues, Arg(961)/Ser(958).	Histidine	23-26	transient receptor potential cation channel subfamily M member 2	Homo sapiens	39-45
21602277-7	2011	Reciprocal mutation of His(995) in the hTRPM2 channel and the equivalent Gln(992) in the mTRPM2 channel completely swapped the kinetics, but no such opposing effects resulted from exchanging another pair of species-specific residues, Arg(961)/Ser(958).	Histidine	23-26	transient receptor potential cation channel, subfamily M, member 2	Mus musculus	89-95
7524680-3	1994	Overall, the histidine residues in FKBP and CyP are very acidic with pKa values ranging from &lt; or = 2.8 to 6.5, indicating that they are predominantly uncharged at physiological pH.	Histidine	13-22	peptidylprolyl isomerase G	Homo sapiens	44-47
7524680-5	1994	The abnormally acidic pKa"s of His-25 in FKBP and His-54 in CyP could be explained by their highly positively charged environments.	Histidine	31-34	peptidylprolyl isomerase G	Homo sapiens	60-63
7524680-5	1994	The abnormally acidic pKa"s of His-25 in FKBP and His-54 in CyP could be explained by their highly positively charged environments.	Histidine	50-53	peptidylprolyl isomerase G	Homo sapiens	60-63
7524680-7	1994	His-126, which is part of the CsA and substrate binding site, has a pKa of 6.3 in free CyP.	Histidine	0-3	peptidylprolyl isomerase G	Homo sapiens	87-90
7524680-8	1994	The pKa values of these two histidine residues in the free proteins are higher than the pKa"s obtained for the peptidyl prolyl cis-trans isomerase (PPiase) activity of these enzymes, indicating that the acid/base characters of His-87 of FKBP and His-126 of CyP are not essential in the PPiase catalysis.	Histidine	227-230	peptidylprolyl isomerase G	Homo sapiens	257-260
21895963-6	2012	The molecular interaction of PED/PEA-15 with 67LR was confirmed by pull-down experiments with recombinant His-tagged 37LRP on lysates of PED/PEA-15 transfected HEK-293 cells.	Histidine	106-109	proliferation and apoptosis adaptor protein 15	Homo sapiens	33-39
7957084-3	1994	Among such suppressors, arcB and barA are of particular interest because these gene products are unique in the sense that they contain both an autophosphorylated histidine site (or transmitter module) and a phospho-accepting aspartate site (or receiver module) in their primary amino acid sequences.	Histidine	162-171	hypothetical protein	Escherichia coli	24-28
7957084-4	1994	Here we report that ArcB and BarA possess in the C-terminal region a phosphorylated histidine site which has never been noticed, in addition to the authentic one identified previously.	Histidine	84-93	hypothetical protein	Escherichia coli	20-24
21718950-2	2011	PROCEDURE: N(epsilon)-functionalized histidine derivative was coupled to the N-terminus of core peptide (CP) and HAP-1 to allow coupling of (99m)Tc-tricarbonyl linker (Isolink).	Histidine	37-46	huntingtin-associated protein 1	Rattus norvegicus	113-118
21895963-6	2012	The molecular interaction of PED/PEA-15 with 67LR was confirmed by pull-down experiments with recombinant His-tagged 37LRP on lysates of PED/PEA-15 transfected HEK-293 cells.	Histidine	106-109	proliferation and apoptosis adaptor protein 15	Homo sapiens	141-147
22552365-4	2012	Our results demonstrated that the cells expressing the hCTR1 mutants of histidine-rich motifs in the N-terminus (H22-24A, NHA) resulted in a higher basal copper level in the steady state compared to those expressing wild-type protein.	Histidine	72-81	solute carrier family 31 member 1	Homo sapiens	55-60
21289295-0	2011	A histidine-rich motif mediates mitochondrial localization of ZnT2 to modulate mitochondrial function.	Histidine	2-11	solute carrier family 30 member 2	Homo sapiens	62-66
21289295-7	2011	Confocal microscopy of truncated and point mutants of ZnT2-green fluorescent protein (GFP) fusion proteins revealed a histidine-rich motif ((51)HHXH(54)) in the NH(2) terminus that is important for mitochondrial targeting of ZnT2.	Histidine	118-127	solute carrier family 30 member 2	Homo sapiens	54-58
21289295-7	2011	Confocal microscopy of truncated and point mutants of ZnT2-green fluorescent protein (GFP) fusion proteins revealed a histidine-rich motif ((51)HHXH(54)) in the NH(2) terminus that is important for mitochondrial targeting of ZnT2.	Histidine	118-127	solute carrier family 30 member 2	Homo sapiens	225-229
7535613-6	1994	In the resulting PSA structure, the catalytic triad, involving residues His 57, Asp 102, and Ser 195, and hydrophobic and electrostatic interactions typical of serine proteases were extremely well conserved.	Histidine	72-75	kallikrein related peptidase 3	Homo sapiens	17-20
22556417-6	2012	Simultaneous mutation of these three histidines to alanines decreased the zinc potency of hP2X2 nearly 100-fold.	Histidine	37-47	purinergic receptor P2X 2	Homo sapiens	90-95
7945384-2	1994	Sequence analysis showed that PLC-alpha is highly conserved among rat, mouse, and calf and that it has two Trp-Cys-Gly-His-Cys-Lys motifs completely conserved in the mammals.	Histidine	119-122	protein disulfide isomerase associated 3	Mus musculus	30-39
7945384-5	1994	PLC-alpha is supposed to be a member not of PLC superfamily but of Trp-Cys-Gly-His-Cys-Lys motif-containing proteins consisting of protein disulfide isomerase, P5, ERp72, and thioredoxin.	Histidine	79-82	protein disulfide isomerase associated 3	Mus musculus	0-9
21390047-4	2011	Indeed, the univariate hazard ratio (HR) was 2.8 times higher for patients with ERCC5 1104 His/His (P&lt;0.001) compared with ERCC5 1104 Asp/Asp.	Histidine	91-94	ERCC excision repair 5, endonuclease	Homo sapiens	80-85
21390047-4	2011	Indeed, the univariate hazard ratio (HR) was 2.8 times higher for patients with ERCC5 1104 His/His (P&lt;0.001) compared with ERCC5 1104 Asp/Asp.	Histidine	95-98	ERCC excision repair 5, endonuclease	Homo sapiens	80-85
21390047-5	2011	Accordingly, the 5-year survival rate was 55% (95% confidence interval 43-71) for patients with ERCC5 1104 His/His, whereas 82% (95% confidence interval 78-86) of patients with ERCC5 1104 Asp/Asp were still alive at this time.	Histidine	107-110	ERCC excision repair 5, endonuclease	Homo sapiens	96-101
22196020-5	2012	Five examples of these secondary interactions are discussed: carbonic anhydrase (where secondary interactions involving histidine residues stabilize the zinc-binding site thermodynamically and kinetically), retroviral nucleocapsid proteins and TRAF proteins (where cysteinate sulfur to peptide NH hydrogen bonds contribute to the structural relationships between adjacent domains), and nucleic acid binding proteins, Zif268 and TIS11 where secondary interactions participate in protein-nucleic acid interactions.	Histidine	120-129	early growth response 1	Homo sapiens	417-423
21143365-9	2011	Proinsulin from tobacco leaves was purified up to 98% using metal affinity chromatography without any His-tag.	Histidine	102-105	insulin II	Mus musculus	0-10
22415292-3	2012	In the presence of Cu(2+), remarkable myoglobin binding to the binary monolayers resulted from the formation of ternary complexes of iminodiacetate (IDA)-Cu(2+)-surface histidine.	Histidine	169-178	myoglobin	Homo sapiens	38-47
21377473-8	2011	We propose a model of the tetrahedral coordination of a Zn(2+) by (Cys)(3)His residues that is compatible with SS2 formation in S100A3.	Histidine	74-77	butyrophilin like 2	Homo sapiens	111-114
8091132-2	1994	An exchange of phe195 with a tyrosine residue does not affect Tcr/CD3 membrane expression; however, exchange with aspartic acid, histidine or valine prohibit completely Tcr/CD3 membrane expression.	Histidine	129-138	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	169-172
26593369-5	2012	Since the EPR results seemingly cannot be used to unequivocally assign the protonation states, the pKa values of the two histidines were calculated using the popular PROPKA, H++, and APBS approaches, in various environments and for several lesions.	Histidine	121-131	Protein kinase, cAMP-dependent, catalytic subunit 2	Drosophila melanogaster	99-102
8049222-9	1994	Iso-1-MS and Comp1-MS contain a histidine residue at position 26 while iso-2 and the other two composites do not.	Histidine	32-41	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	0-5
7920712-1	1994	Complete DNA sequences encoding the Arabidopsis thaliana STP1 monosaccharide/H+ symporter or a histidine-tagged STP1-His6 protein were expressed in baker"s yeast Saccharomyces cerevisiae.	Histidine	95-104	sugar transporter 1	Arabidopsis thaliana	112-116
20960216-9	2011	Moreover, the partial rescue of the impl2 phenotype by histidine application implies that IMPL2 is also involved in histidine biosynthesis during embryo development.	Histidine	55-64	inositol monophosphatase family protein	Arabidopsis thaliana	36-41
20960216-9	2011	Moreover, the partial rescue of the impl2 phenotype by histidine application implies that IMPL2 is also involved in histidine biosynthesis during embryo development.	Histidine	55-64	inositol monophosphatase family protein	Arabidopsis thaliana	90-95
20960216-9	2011	Moreover, the partial rescue of the impl2 phenotype by histidine application implies that IMPL2 is also involved in histidine biosynthesis during embryo development.	Histidine	116-125	inositol monophosphatase family protein	Arabidopsis thaliana	36-41
20960216-9	2011	Moreover, the partial rescue of the impl2 phenotype by histidine application implies that IMPL2 is also involved in histidine biosynthesis during embryo development.	Histidine	116-125	inositol monophosphatase family protein	Arabidopsis thaliana	90-95
22590679-5	2012	However, when dialyzed together with Gst-gp3 or with Gst-gp4, His-gp2b and His-gp4 remain soluble and oligomers are obtained by affinity-chromatography.	Histidine	75-78	CD36 molecule	Homo sapiens	57-60
8033906-2	1994	Synthetic peptides related to amino acid residues 29-42 of human serum amyloid A (SAA), Tyr-Ile-Gly-Ser-Asp-Lys-Tyr-Phe-His-Ala-Arg-Gly-Asn-Tyr, were found to inhibit the adhesion of human T-lymphocytes and of mouse M4 melanoma cells to surfaces coated with the major cell adhesive glycoproteins of the extracellular matrix, laminin or fibronectin.	Histidine	120-123	fibronectin 1	Mus musculus	336-347
22590679-5	2012	However, when dialyzed together with Gst-gp3 or with Gst-gp4, His-gp2b and His-gp4 remain soluble and oligomers are obtained by affinity-chromatography.	Histidine	75-78	CD36 molecule	Homo sapiens	79-82
21505254-3	2011	In this study, the N-terminal domain of human RPL7a was overexpressed in Escherichia coli using an engineered C-terminal His tag.	Histidine	121-124	ribosomal protein L7a	Homo sapiens	46-51
22174408-4	2012	By contrast, the plasma membrane CeHRG-4 transports heme by utilizing a histidine in the exoplasmic (E2) loop and the FARKY motif.	Histidine	72-81	Heme transporter hrg-4	Caenorhabditis elegans	33-40
8011627-0	1994	Electron-nuclear coupling to the proximal histidine in oxy cobalt-substituted distal histidine mutants of human myoglobin.	Histidine	42-51	myoglobin	Homo sapiens	112-121
8011627-0	1994	Electron-nuclear coupling to the proximal histidine in oxy cobalt-substituted distal histidine mutants of human myoglobin.	Histidine	85-94	myoglobin	Homo sapiens	112-121
22174408-6	2012	An analogous system exists in humans, because mutation of the synonymous histidine in TMD2 of hHRG-1 eliminates heme transport activity, implying an evolutionary conserved heme transport mechanism that predates vertebrate origins.	Histidine	73-82	solute carrier family 48 member 1	Homo sapiens	94-100
22236003-8	2012	Our results show that glycine, histidine and cysteine can inhibit NF-kappaB activation, IkappaBalpha degradation, CD62E expression and IL-6 production in HCAECs, suggesting that these amino acids may exhibit anti-inflammatory effects during endothelial inflammation.	Histidine	31-40	selectin E	Homo sapiens	114-119
21455490-5	2011	C. elegans haly-1 encodes a protein that is homologous to vertebrate HAL, an enzyme that converts histidine to urocanic acid.	Histidine	98-107	Histidine ammonia-lyase	Caenorhabditis elegans	11-17
22068049-9	2012	The serum IgG2a levels induced by Gag p41-His-Ni-NCs (1 mug) were significantly higher than AH adjuvanted His-Gag p41.	Histidine	42-45	immunoglobulin heavy variable V1-9	Mus musculus	10-15
21455490-6	2011	haly-1 mutant animals displayed elevated levels of histidine, indicating that C. elegans HALY-1 protein is an enzyme involved in histidine catabolism.	Histidine	51-60	Histidine ammonia-lyase	Caenorhabditis elegans	0-6
21455490-6	2011	haly-1 mutant animals displayed elevated levels of histidine, indicating that C. elegans HALY-1 protein is an enzyme involved in histidine catabolism.	Histidine	51-60	Histidine ammonia-lyase	Caenorhabditis elegans	89-95
21455490-6	2011	haly-1 mutant animals displayed elevated levels of histidine, indicating that C. elegans HALY-1 protein is an enzyme involved in histidine catabolism.	Histidine	129-138	Histidine ammonia-lyase	Caenorhabditis elegans	0-6
8003512-5	1994	In addition, the substitution of residue 23 with His or Tyr produced an hEGF variant with a slightly higher receptor-binding affinity than that of [Phe23]hEGF.	Histidine	49-52	epidermal growth factor	Homo sapiens	72-76
8003512-5	1994	In addition, the substitution of residue 23 with His or Tyr produced an hEGF variant with a slightly higher receptor-binding affinity than that of [Phe23]hEGF.	Histidine	49-52	epidermal growth factor	Homo sapiens	154-158
21455490-6	2011	haly-1 mutant animals displayed elevated levels of histidine, indicating that C. elegans HALY-1 protein is an enzyme involved in histidine catabolism.	Histidine	129-138	Histidine ammonia-lyase	Caenorhabditis elegans	89-95
22105071-8	2012	Simultaneous mutation of residues Cys-188, Cys-195, His-199, His-201, and His-202 in this domain significantly compromised MOV10 anti-HIV-1 activity.	Histidine	52-55	Mov10 RISC complex RNA helicase	Homo sapiens	123-128
21604555-7	2011	RESULTS: Soluble expression of orf20 gene in E. coli was achieved, and the recombinant ORF20 protein was tagged by seven histidines at the carboxylic end.	Histidine	121-131	hypothetical protein	Escherichia coli	87-92
21167151-5	2011	The intake of histidine or carnosine significantly diminished the activity and mRNA expression of malic enzyme, FAS, HMG-CoA reductase, SREBP-1c and SREBP-2, which led to lower body weight, epididymal fat, and hepatic triglyceride and cholesterol levels (P&lt;0.05).	Histidine	14-23	sterol regulatory element binding factor 2	Mus musculus	149-156
8204626-2	1994	Under typical denaturing conditions (concentrated guanidine hydrochloride or urea near pH 7), one of the axial ligands, His 18, remains bound to the oxidized heme iron, but the second ligand, Met 80, is replaced by a non-native histidine ligand (His 26 or His 33 in horse cytochrome c).	Histidine	120-123	cytochrome c, somatic	Equus caballus	272-284
8204626-5	1994	Heme absorbance changes induced by rapid acidification of oxidized cytochrome c in 4.5 M guanidine hydrochloride from pH 7.8 to 4.6 or below exhibit two kinetic phases with rates of 110 and 25 s-1, attributed to the dissociation of non-native histidine ligands from the heme in the unfolded state.	Histidine	243-252	cytochrome c, somatic	Equus caballus	67-79
8074930-3	1994	GST fusion proteins can be purified on immobilized glutathione and proteins coupled to the His tag selectively bind to Ni(2+)-NTA columns.	Histidine	91-94	hematopoietic prostaglandin D synthase	Mus musculus	0-3
22105071-8	2012	Simultaneous mutation of residues Cys-188, Cys-195, His-199, His-201, and His-202 in this domain significantly compromised MOV10 anti-HIV-1 activity.	Histidine	61-64	Mov10 RISC complex RNA helicase	Homo sapiens	123-128
8074930-9	1994	Multivalent SMAA complexes were made that contained His-p17-Pk, His-p27-Pk, His-rt-Pk, His-vpx-Pk, and His-vpr-Pk.	Histidine	64-67	dynactin 6	Mus musculus	68-71
8074930-9	1994	Multivalent SMAA complexes were made that contained His-p17-Pk, His-p27-Pk, His-rt-Pk, His-vpx-Pk, and His-vpr-Pk.	Histidine	64-67	dynactin 6	Mus musculus	68-71
21687413-6	2011	We confirmed the binding domains using a pull-down assay and showed that GST-CdsN(221-270), which encompasses these peptides, co-purified with His-CdsL.	Histidine	143-146	corneodesmosin	Homo sapiens	77-81
8074930-9	1994	Multivalent SMAA complexes were made that contained His-p17-Pk, His-p27-Pk, His-rt-Pk, His-vpx-Pk, and His-vpr-Pk.	Histidine	64-67	dynactin 6	Mus musculus	68-71
22105071-8	2012	Simultaneous mutation of residues Cys-188, Cys-195, His-199, His-201, and His-202 in this domain significantly compromised MOV10 anti-HIV-1 activity.	Histidine	61-64	Mov10 RISC complex RNA helicase	Homo sapiens	123-128
8074930-9	1994	Multivalent SMAA complexes were made that contained His-p17-Pk, His-p27-Pk, His-rt-Pk, His-vpx-Pk, and His-vpr-Pk.	Histidine	64-67	dynactin 6	Mus musculus	68-71
20641535-0	2004	(111)In-DOTA-Gly-benzoyl-D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2 The amphibian bombesin (BBN or BN, a peptide of 14 amino acids) is an analog of human gastrin-releasing peptide (GRP, a peptide of 27 amino acids) that binds to GRP receptors (GRPR) with high affinity and specificity (1).	Histidine	51-54	gastrin releasing peptide	Homo sapiens	81-89
21719207-0	2012	Heat-induced gelation of myosin in a low ionic strength solution containing L-histidine.	Histidine	76-87	myosin heavy chain 14	Homo sapiens	25-31
21709760-0	2011	Locostatin Disrupts Association of Raf Kinase Inhibitor Protein With Binding Proteins by Modifying a Conserved Histidine Residue in the Ligand-Binding Pocket.	Histidine	111-120	phosphatidylethanolamine binding protein 1	Homo sapiens	35-63
8175672-1	1994	The metalloendopeptidase EC 3.4.24.15 is believed to degrade gonadotropin-releasing hormone (GnRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2) by cleavage at the Tyr5-Gly6 bond.	Histidine	105-108	gonadotropin releasing hormone 1	Rattus norvegicus	61-91
8175672-1	1994	The metalloendopeptidase EC 3.4.24.15 is believed to degrade gonadotropin-releasing hormone (GnRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2) by cleavage at the Tyr5-Gly6 bond.	Histidine	105-108	gonadotropin releasing hormone 1	Rattus norvegicus	93-97
21719207-2	2012	We have shown that myosin is solubilized in a low ionic strength solution containing L-histidine.	Histidine	85-96	myosin heavy chain 14	Homo sapiens	19-25
21446168-3	2011	Plasmid pFastBacHTb-Hsp70 containing sequence coding HSP70 gene with insertion of 6 histidine residues in protein reading frame was constructed.	Histidine	84-93	heat shock protein family A (Hsp70) member 4	Homo sapiens	20-25
21719207-4	2012	Myosin in a low ionic strength solution formed transparent gels at 40-50 C, while myosin in a high ionic strength solution formed opaque gels at 60-70 C. The gel of myosin in a low ionic strength solution with L-histidine showed a fine network consisting of thin strands and its viscosity was lower than that of myosin in a high ionic strength solution at 40-50 C. The rheological properties of heat-induced gels of myosin at low ionic strength are different from those at high ionic strength.	Histidine	210-221	myosin heavy chain 14	Homo sapiens	82-88
20934430-0	2010	Alternative oligomeric states of the yeast Rvb1/Rvb2 complex induced by histidine tags.	Histidine	72-81	RuvB family ATP-dependent DNA helicase reptin	Saccharomyces cerevisiae S288C	48-52
21719207-4	2012	Myosin in a low ionic strength solution formed transparent gels at 40-50 C, while myosin in a high ionic strength solution formed opaque gels at 60-70 C. The gel of myosin in a low ionic strength solution with L-histidine showed a fine network consisting of thin strands and its viscosity was lower than that of myosin in a high ionic strength solution at 40-50 C. The rheological properties of heat-induced gels of myosin at low ionic strength are different from those at high ionic strength.	Histidine	210-221	myosin heavy chain 14	Homo sapiens	165-171
20934430-4	2010	We found that histidine-tagged constructs of yeast Rvb proteins employed in some of these studies induced the assembly of double hexameric ring Rvb1/Rvb2 complexes.	Histidine	14-23	RuvB family ATP-dependent DNA helicase reptin	Saccharomyces cerevisiae S288C	149-153
8155728-4	1994	The fact that butyrate ester has the optimum acyl-chain length to be a substrate of LPL can be attributed to its chain length being long enough for optimum interaction with the active site His-Ser-Asp triad in forming the transition state complex; yet it is short enough to provide freedom for optimum positioning of the ester bond for transition state complex formation.	Histidine	189-192	lipoprotein lipase	Homo sapiens	84-87
21719207-4	2012	Myosin in a low ionic strength solution formed transparent gels at 40-50 C, while myosin in a high ionic strength solution formed opaque gels at 60-70 C. The gel of myosin in a low ionic strength solution with L-histidine showed a fine network consisting of thin strands and its viscosity was lower than that of myosin in a high ionic strength solution at 40-50 C. The rheological properties of heat-induced gels of myosin at low ionic strength are different from those at high ionic strength.	Histidine	210-221	myosin heavy chain 14	Homo sapiens	165-171
8018603-5	1994	Unlike C1r-C1s, however, MASP has a histidine loop structure common to many serine proteases such as trypsin and chymotrypsin.	Histidine	36-45	MBL associated serine protease 1	Homo sapiens	25-29
21139689-9	2010	SDS-PAGE analysis exhibited autodegradation products with Mr of 22, 27 and 30 kDa, which on partial NH2-terminal sequencing showed cleavage of Lys17-Met18, Gln4-Ala5 and Thr-Gly (in the NH2-terminal His-tag region) bonds, respectively.	Histidine	199-202	MMS19 homolog, cytosolic iron-sulfur assembly component	Homo sapiens	149-154
21719207-4	2012	Myosin in a low ionic strength solution formed transparent gels at 40-50 C, while myosin in a high ionic strength solution formed opaque gels at 60-70 C. The gel of myosin in a low ionic strength solution with L-histidine showed a fine network consisting of thin strands and its viscosity was lower than that of myosin in a high ionic strength solution at 40-50 C. The rheological properties of heat-induced gels of myosin at low ionic strength are different from those at high ionic strength.	Histidine	210-221	myosin heavy chain 14	Homo sapiens	165-171
21719207-5	2012	This difference might be caused by structural changes in the rod region of myosin in a low ionic strength solution containing L-histidine.	Histidine	126-137	myosin heavy chain 14	Homo sapiens	75-81
22118311-8	2011	RESULTS: Subjects with EPHX1 113 (His(113)/His(113)) homozygote mutation had a strong correlation with COPD (odds ratio: 2.7, 95% confidence interval: 1.5-5.2).	Histidine	34-37	epoxide hydrolase 1	Homo sapiens	23-28
21055628-6	2010	[(99m)Tc]-(CO)(3) His-annexin A5 was also evaluated for in vivo imaging of spontaneous apoptosis in Colo205-bearing mice (n=12).	Histidine	18-21	annexin A5	Mus musculus	22-32
21055628-9	2010	[(99m)Tc]-(CO)(3) His-annexin A5 rapidly cleared from the blood and predominantly accumulated in the kidneys.	Histidine	18-21	annexin A5	Mus musculus	22-32
21055628-12	2010	Spontaneous apoptosis in Colo205-bearing mice was visualised by [(99m)Tc]-(CO)(3) His-annexin A5 SPECT and correlated well with caspase-3 immunostaining (R=0.867, P&lt;.01).	Histidine	82-85	annexin A5	Mus musculus	86-96
8159793-4	1994	The second transcript encoded the SbHRGP-2 protein containing the 16-amino acid repeat Ser-Pro4-Ser-Pro-Ser-Pro4-Tyr-Tyr-Tyr-Lys/His.	Histidine	129-132	extensin-2	Glycine max	34-42
8288565-2	1994	A genetically engineered human myoglobin (Mb) in which the distal His, His64(E7), and the distal Val, Val68(E11), are replaced by Val and His, respectively, has been expressed in Escherichia coli, for the purpose of assessing the potential role of a E11 residue in providing a hydrogen bond donor to the coordinated ligand.	Histidine	71-74	myoglobin	Homo sapiens	31-40
8278375-0	1994	Histidine-367 of the human common beta chain of the receptor is critical for high-affinity binding of human granulocyte-macrophage colony-stimulating factor.	Histidine	0-9	colony stimulating factor 2	Homo sapiens	108-156
22118311-8	2011	RESULTS: Subjects with EPHX1 113 (His(113)/His(113)) homozygote mutation had a strong correlation with COPD (odds ratio: 2.7, 95% confidence interval: 1.5-5.2).	Histidine	43-46	epoxide hydrolase 1	Homo sapiens	23-28
20880231-1	2010	The effect of 8-methoxypsoralen-UVA therapy on the catalysis of histidine to trans-urocanic acid by histidine ammonia lyase (HAL, EC 4.3.1.3) was examined using an enzymatic assay from Sigma-Aldrich where the growth of the trans-urocanic acid peak at 277 nm was monitored.	Histidine	64-73	histidine ammonia-lyase	Homo sapiens	100-123
20880231-1	2010	The effect of 8-methoxypsoralen-UVA therapy on the catalysis of histidine to trans-urocanic acid by histidine ammonia lyase (HAL, EC 4.3.1.3) was examined using an enzymatic assay from Sigma-Aldrich where the growth of the trans-urocanic acid peak at 277 nm was monitored.	Histidine	64-73	histidine ammonia-lyase	Homo sapiens	125-128
23888104-2	2011	These studies were conducted to determine hPHT1-mediated, H+-dependent uptake kinetics of histidine, carnosine, Gly-Sar and valacyclovir in stably transfected hPHT1-COS-7 cells comparative to kinetics determined in an empty vector (Mock) stably transfected cell line.	Histidine	90-99	solute carrier family 15 member 4	Homo sapiens	42-47
21048924-8	2010	RESULTS: The ADH1B*47Arg allele was found to be associated to increased risk of ESCC, with the odds ratios (OR) being 1.62 (95% CI: 1.49-1.76) and 3.86 (2.96-5.03) for the His/Arg and the Arg/Arg genotypes, respectively.	Histidine	172-175	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	13-18
7994366-2	1994	In myoglobin, His-E7 inhibits CO binding by requiring displacement of distal pocket water.	Histidine	14-17	myoglobin	Homo sapiens	3-12
7994366-9	1994	The apoprotein of His-E7--&gt;Tyr myoglobin has been used to extract hemin from other myoglobins and hemoglobin, causing a brown to green color change.	Histidine	18-21	myoglobin	Homo sapiens	34-43
21616146-3	2011	Here we used the yeast two-hybrid system to demonstrate that FGFRL1 binds with its C-terminal, histidine-rich domain to Spred1 and to other proteins of the Sprouty/Spred family.	Histidine	95-104	sprouty related EVH1 domain containing 1	Homo sapiens	120-126
8148817-3	1994	When delipidated apo B was treated with linoleic acid 13-mono-hydroperoxide (LOOH) and trans-2-octenal (octenal), apo B became fluorescent and its Lys and histidine (His) residues were decreased.	Histidine	155-164	apolipoprotein B	Mus musculus	17-22
8148817-3	1994	When delipidated apo B was treated with linoleic acid 13-mono-hydroperoxide (LOOH) and trans-2-octenal (octenal), apo B became fluorescent and its Lys and histidine (His) residues were decreased.	Histidine	166-169	apolipoprotein B	Mus musculus	17-22
8148817-3	1994	When delipidated apo B was treated with linoleic acid 13-mono-hydroperoxide (LOOH) and trans-2-octenal (octenal), apo B became fluorescent and its Lys and histidine (His) residues were decreased.	Histidine	166-169	apolipoprotein B	Mus musculus	114-119
20660104-4	2010	We found the permeability of GlySar to be saturable (K(m) = 5.7 mM), pH-dependent (maximal value at pH 5.5), and specific for PEPT1; other peptide transporters, such as PHT1 and PHT2, were not involved, as judged by the lack of GlySar inhibition by excess concentrations of histidine.	Histidine	274-283	solute carrier family 15 (oligopeptide transporter), member 1	Mus musculus	126-131
21882401-0	2004	3-Cyano-4-[(18)F]fluoro-benzoyl-Ala(SO3H)-Ala(SO3H)-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2 The amphibian bombesin (BBN or BN, a peptide of 14 amino acids) is an analog of human gastrin-releasing peptide (GRP, a peptide of 27 amino acids), which binds to the GRP receptor (GRPR) with high affinity and specificity (1).	Histidine	79-82	GCY	Homo sapiens	83-86
20811687-4	2010	In this study, human NKG2F recombinant expression in E. coli was carried out by using pET-28a with a hexahistidine (6x His) tag and a thrombin digestion sequence to the N-terminus of the recombinant protein NKG2F.	Histidine	119-122	killer cell lectin like receptor C4	Homo sapiens	21-26
8264637-4	1994	Affinity chromatography of extract from EM9 cells transfected with pcD2EHX resulted in the copurification of histidine-tagged XRCC1 and DNA ligase III activity.	Histidine	109-118	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	40-43
21749116-7	2011	LC-MS/MS analyses of tryptic digests by identified His(450) and His(490) of Hsp90alpha as having a 158 Da modification, corresponding to NaBH(4)-reduced HNE adducts.	Histidine	51-54	heat shock protein 90 alpha family class A member 1	Homo sapiens	76-86
8264637-6	1994	The copurification of DNA ligase III activity with histidine-tagged XRCC1 suggests that the two proteins are present in the cell as a complex.	Histidine	51-60	DNA ligase 3	Homo sapiens	22-36
20660596-5	2010	We have shown previously that this coding change (Y402H; from a tyrosine to histidine residue) alters the binding of the CFH protein to sulfated polysaccharides.	Histidine	76-85	complement factor H	Homo sapiens	121-124
21567851-5	2010	A fusion protein, malate dehydrogenase-green fluorescent protein with a histidine affinity tag (MGH), is used throughout the semester.	Histidine	72-81	malic enzyme 1	Homo sapiens	18-38
8223474-2	1993	The DNA-binding domain of HAP2 is shown to be a 21 residue region containing three critical histidines and three critical arginines.	Histidine	92-102	transcription activator HAP2	Saccharomyces cerevisiae S288C	26-30
21749116-7	2011	LC-MS/MS analyses of tryptic digests by identified His(450) and His(490) of Hsp90alpha as having a 158 Da modification, corresponding to NaBH(4)-reduced HNE adducts.	Histidine	64-67	heat shock protein 90 alpha family class A member 1	Homo sapiens	76-86
21749116-8	2011	Five histidine residues were also adducted on Hsp90beta: His(171), His(442), His(458), His(625), and His(632).	Histidine	5-14	heat shock protein 90 alpha family class B member 1	Homo sapiens	46-55
21749116-8	2011	Five histidine residues were also adducted on Hsp90beta: His(171), His(442), His(458), His(625), and His(632).	Histidine	57-60	heat shock protein 90 alpha family class B member 1	Homo sapiens	46-55
21749116-8	2011	Five histidine residues were also adducted on Hsp90beta: His(171), His(442), His(458), His(625), and His(632).	Histidine	67-70	heat shock protein 90 alpha family class B member 1	Homo sapiens	46-55
21749116-8	2011	Five histidine residues were also adducted on Hsp90beta: His(171), His(442), His(458), His(625), and His(632).	Histidine	67-70	heat shock protein 90 alpha family class B member 1	Homo sapiens	46-55
20664961-2	2010	It has also been linked with the change of leucine (L) to histidine (H) or arginine (R) at amino acid position 48 (FcgammaRIIIa-48L/R/H) in the CD16a receptor.	Histidine	58-67	Fc gamma receptor IIIa	Homo sapiens	115-127
21749116-8	2011	Five histidine residues were also adducted on Hsp90beta: His(171), His(442), His(458), His(625), and His(632).	Histidine	67-70	heat shock protein 90 alpha family class B member 1	Homo sapiens	46-55
20664961-2	2010	It has also been linked with the change of leucine (L) to histidine (H) or arginine (R) at amino acid position 48 (FcgammaRIIIa-48L/R/H) in the CD16a receptor.	Histidine	58-67	Fc gamma receptor IIIa	Homo sapiens	144-149
8250906-2	1993	The helix-stabilizing tendency of N-terminal amino acid in NPY (12-36) was found to be as follows: Thr &gt; Ser &gt; Gly &gt; Gln &gt; Cys &gt; Asn &gt; Asp &gt; Val &gt; Phe &gt; Glu &gt; Lys &gt; Tyr &gt; Ala = Trp &gt; His &gt; Arg, suggesting the importance of end capping.	Histidine	222-225	neuropeptide Y	Homo sapiens	59-62
21749116-8	2011	Five histidine residues were also adducted on Hsp90beta: His(171), His(442), His(458), His(625), and His(632).	Histidine	67-70	heat shock protein 90 alpha family class B member 1	Homo sapiens	46-55
21749116-11	2011	Within the middle client-binding domain of Hsp90alpha, residue His(450) demonstrated the most rapid adduction with k(obs) of 1.08 +- 0.17 h(-1) in HNE-treated cells.	Histidine	63-66	heat shock protein 90 alpha family class A member 1	Homo sapiens	43-53
21749116-12	2011	The homologous residue on Hsp90beta, His(442), was adducted more rapidly than the N-terminal residue, His(171), despite very similar predicted pK(a) values of both residues.	Histidine	37-40	heat shock protein 90 alpha family class B member 1	Homo sapiens	26-35
21680741-7	2011	These data indicated that His-396 is important for the formation of the C4a-hydroperoxy-FMN intermediate but is not involved in H(2)O(2) elimination.	Histidine	26-29	complement C4A (Rodgers blood group)	Homo sapiens	72-75
8298023-1	1993	The causes of the strong coupling of the iron-histidine vibration to the Soret resonance in the resonance Raman spectra of deoxyhemoglobin, myoglobin, and peroxidase are explored, using the vibronic theory.	Histidine	46-55	myoglobin	Homo sapiens	140-149
20530481-8	2010	To analyze linkage to hydrolytic activity, we introduced several point mutations and show that residues His(114) and His(133) are essential for PON2 activity.	Histidine	104-107	paraoxonase 2	Homo sapiens	144-148
20530481-8	2010	To analyze linkage to hydrolytic activity, we introduced several point mutations and show that residues His(114) and His(133) are essential for PON2 activity.	Histidine	117-120	paraoxonase 2	Homo sapiens	144-148
21543521-7	2011	The results suggest that HCC1 is the protein involved in COX biogenesis and that HCC2, that lacks the cysteines and histidine putatively involved in copper binding, functions in copper sensing and redox homeostasis.	Histidine	116-125	Thioredoxin superfamily protein	Arabidopsis thaliana	81-85
20693691-0	2010	Structural basis of the histidine-mediated vitamin D receptor agonistic and antagonistic mechanisms of (23S)-25-dehydro-1alpha-hydroxyvitamin D3-26,23-lactone.	Histidine	24-33	vitamin D receptor	Homo sapiens	43-61
8400292-1	1993	Heterozygosity for a G-->C mutation converting the highly conserved Gln184 (CAG) to His (CAC) was identified at the last nucleotide of exon 7 of the protein C gene in two family members with deep vein thrombosis.	Histidine	84-87	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	149-158
21531719-5	2011	With this aim, we first produced a recombinant form of FLG2 corresponding to subunits B7 to B10 fused to a COOH-terminal His tag.	Histidine	121-124	filaggrin 2	Homo sapiens	55-59
8274660-4	1993	CO replaces histidine as the axial sixth ligand at each heme site, forming a low-spin complex with an MCD spectrum similar to that of myoglobin-CO. Photodissociation of Cc3-CO (observed photolysis yield = 30%) produces a transient five-coordinate, high-spin (S = 2) species with an MCD spectrum similar to deoxymyoglobin.	Histidine	12-21	C-C motif chemokine ligand 14	Homo sapiens	169-172
20402667-2	2010	Here, we have characterized a novel USP44 (ubiquitin-specific protease 44), which has a ZnF-UBP (zinc-finger ubiquitin-specific protease) domain and conserved cysteine, histidine and asparagine/aspartic acid residues characteristic of deubiquitinating enzymes.	Histidine	169-178	ubiquitin specific peptidase 44	Mus musculus	36-41
20402667-2	2010	Here, we have characterized a novel USP44 (ubiquitin-specific protease 44), which has a ZnF-UBP (zinc-finger ubiquitin-specific protease) domain and conserved cysteine, histidine and asparagine/aspartic acid residues characteristic of deubiquitinating enzymes.	Histidine	169-178	ubiquitin specific peptidase 44	Mus musculus	43-73
21531719-6	2011	Incubation with calpain 1 in the presence of calcium induced a rapid degradation of the recombinant protein and the production of several peptides, as shown by Coomassie Blue-stained gels and Western blotting with anti-FLG2 or anti-His antibodies.	Histidine	232-235	calpain 1	Homo sapiens	16-25
20484158-9	2010	In addition, we find that His(132), Val(134), and Asn(141) in human ssTnI, previously identified as enabling contractile function during cellular acidosis, are present in all vertebrate cTnI isoforms except those from monotremes, marsupials, and eutherian mammals.	Histidine	26-29	troponin I3, cardiac type	Homo sapiens	186-190
8397193-2	1993	Tetrazole-myoglobin (Tet-Mb), a site selectively modified myoglobin with tetrazole anion (-CN4-) covalently attached to the imidazole N epsilon of the distal histidine 64(E7) (see Fig.	Histidine	158-167	myoglobin	Homo sapiens	10-19
21565198-2	2011	Sequence analysis suggests that Rv2613c belongs to the histidine triad (HIT) motif superfamily, which includes HIT family diadenosine polyphosphate (Ap(n)A) hydrolases and Ap(4)A phosphorylases.	Histidine	55-64	AP-4-A phosphorylase	Mycobacterium tuberculosis H37Rv	32-39
8368516-4	1993	One substrate, Dnp-Pro-Cha-Gly-Cys(Me)-His-Ala-Lys-(Nma)-NH2, had favorable solubility characteristics, was &gt; 98% quenched, and produced a single cleavage product, Dnp-Pro-Cha-Gly, with a high fluorescence yield with both interstitial collagenase and 92-kDa gelatinase.	Histidine	39-42	matrix metallopeptidase 1	Homo sapiens	225-249
8100523-2	1993	They either start with Tyr-Ala, His-Ala or His-Ser which might be in part potential targets for dipeptidyl-peptidase IV, a highly specialized aminopeptidase removing dipeptides only from peptides with N-terminal penultimate proline or alanine.	Histidine	32-35	dipeptidyl peptidase 4	Homo sapiens	96-119
8100523-2	1993	They either start with Tyr-Ala, His-Ala or His-Ser which might be in part potential targets for dipeptidyl-peptidase IV, a highly specialized aminopeptidase removing dipeptides only from peptides with N-terminal penultimate proline or alanine.	Histidine	43-46	dipeptidyl peptidase 4	Homo sapiens	96-119
20568807-10	2010	On the other hand, quantum mechanical calculations at the DFT/B3LYP/6-31++G* allowed us to analyze the energetic, geometrical, and vibrational features of histidine.	Histidine	155-164	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	64-67
20332014-10	2010	GENERAL SIGNIFICANCE: These results indicate that an Escherichiacoli-derived full-length His(8)-tagged human MUC17 CRD1-L-CRD2 recombinant protein is a biologically active candidate for further development as a therapeutic agent.	Histidine	89-92	mucin 17, cell surface associated	Homo sapiens	109-114
21674702-2	2011	Two highly conserved histidines in the sixth transmembrane domain (TMD6) are essential for metal transport activity in DMT1.	Histidine	21-31	solute carrier family 11 member 2	Homo sapiens	119-123
20645695-6	2010	The major action of PAP is to dephosphorylate macromolecules with the help of catalytic residues (His(12) and Asp(258)) that are located in the cleft between two domains.	Histidine	98-101	acid phosphatase 3	Homo sapiens	20-23
21674702-9	2011	The changes in conformation and intermolecular interaction induced by histidine substitution may be correlated with the deficiency of DMT1 in metal-ion permeation.	Histidine	70-79	solute carrier family 11 member 2	Homo sapiens	134-138
8317843-0	1993	Krab domains analyzed in human Cys/His-type zinc-finger proteins KOX 1, KOX 8, and KOX 19.	Histidine	35-38	zinc finger protein 708	Homo sapiens	72-77
19432810-4	2010	Immunochemical staining with anti-His revealed that TAT-aFGF-His proteins were readily found in the retina (mainly in the ganglion cell layer) at 30 min.	Histidine	34-37	fibroblast growth factor 1	Rattus norvegicus	56-60
21666675-2	2011	Most missense mutations in the OCRL ASH-RhoGAP domain that are found in affected individuals abolish interactions with the endocytic adaptors APPL1 and Ses (both Ses1 and Ses2), which bind OCRL through a short phenylalanine and histidine (F&amp;H) motif.	Histidine	228-237	OCRL inositol polyphosphate-5-phosphatase	Homo sapiens	31-35
19432810-8	2010	After IR injury, retina from TAT-aFGF-His-treated rats showed better-maintained inner retinal layer structure, reduced apoptosis of retinal ganglion cells and improved retinal function compared to those treated with aFGF-His or PBS.	Histidine	38-41	fibroblast growth factor 1	Rattus norvegicus	33-37
19432810-8	2010	After IR injury, retina from TAT-aFGF-His-treated rats showed better-maintained inner retinal layer structure, reduced apoptosis of retinal ganglion cells and improved retinal function compared to those treated with aFGF-His or PBS.	Histidine	38-41	fibroblast growth factor 1	Rattus norvegicus	216-220
19432810-8	2010	After IR injury, retina from TAT-aFGF-His-treated rats showed better-maintained inner retinal layer structure, reduced apoptosis of retinal ganglion cells and improved retinal function compared to those treated with aFGF-His or PBS.	Histidine	221-224	fibroblast growth factor 1	Rattus norvegicus	33-37
19432810-9	2010	These results indicate that conjugation of TAT to aFGF-His can markedly improve the ability of aFGF-His to penetrate the ocular barrier without impairing its biological function.	Histidine	55-58	fibroblast growth factor 1	Rattus norvegicus	50-54
19432810-9	2010	These results indicate that conjugation of TAT to aFGF-His can markedly improve the ability of aFGF-His to penetrate the ocular barrier without impairing its biological function.	Histidine	55-58	fibroblast growth factor 1	Rattus norvegicus	95-99
8486696-0	1993	Arginine residues of the globular regions of human C1q involved in the interaction with immunoglobulin G. The immunoglobulin G binding site in the globular regions of human complement subcomponent C1q has been investigated by chemical modification of histidine residues with diethylpyrocarbonate and arginine residues with phenylglyoxal and cyclohexane-1,2-dione (CHD).	Histidine	251-260	complement C1q A chain	Homo sapiens	51-54
8486696-0	1993	Arginine residues of the globular regions of human C1q involved in the interaction with immunoglobulin G. The immunoglobulin G binding site in the globular regions of human complement subcomponent C1q has been investigated by chemical modification of histidine residues with diethylpyrocarbonate and arginine residues with phenylglyoxal and cyclohexane-1,2-dione (CHD).	Histidine	251-260	complement C1q A chain	Homo sapiens	197-200
21666675-2	2011	Most missense mutations in the OCRL ASH-RhoGAP domain that are found in affected individuals abolish interactions with the endocytic adaptors APPL1 and Ses (both Ses1 and Ses2), which bind OCRL through a short phenylalanine and histidine (F&amp;H) motif.	Histidine	228-237	adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1	Homo sapiens	142-147
20403435-1	2010	In the nuclear receptor of vitamin D (VDR) histidine 305 participates to the anchoring of the ligand.	Histidine	43-52	vitamin D receptor	Homo sapiens	38-41
21666675-2	2011	Most missense mutations in the OCRL ASH-RhoGAP domain that are found in affected individuals abolish interactions with the endocytic adaptors APPL1 and Ses (both Ses1 and Ses2), which bind OCRL through a short phenylalanine and histidine (F&amp;H) motif.	Histidine	228-237	OCRL inositol polyphosphate-5-phosphatase	Homo sapiens	189-193
8473309-5	1993	Here we describe the site-specific mutagenesis of the histidine precursor of diphthamide, histidine 699, in yeast EF-2.	Histidine	54-63	elongation factor 2	Saccharomyces cerevisiae S288C	114-118
21586110-6	2011	RESULTS: We show that the human PiT2 histidine, H(502), and the human PiT1 glutamate, E(70),--both conserved in eukaryotic PiT family members--are critical for P(i) transport function.	Histidine	37-46	solute carrier family 20 member 2	Homo sapiens	32-36
8473309-5	1993	Here we describe the site-specific mutagenesis of the histidine precursor of diphthamide, histidine 699, in yeast EF-2.	Histidine	90-99	elongation factor 2	Saccharomyces cerevisiae S288C	114-118
8385134-4	1993	Putative iron-binding sites of phenylalanine hydroxylase were studied by mutating either histidine 284 or 289 to serine and expressing these mutant enzymes (PAH-H284S and PAH-H289S) in Sf9 cells.	Histidine	89-98	phenylalanine hydroxylase	Rattus norvegicus	31-56
20451500-7	2010	Each conserved zinc-finger motif of ZAP coordinates a zinc ion using three cysteines and one histidine.	Histidine	93-102	zinc finger CCCH-type containing, antiviral 1	Homo sapiens	36-39
20436286-4	2010	Mutation of conserved motif C cysteines and histidines disrupted the association of Dbf4 with ARS1 origin DNA and Mcm2, but not other known ligands including Cdc7, Rad53 or the origin recognition complex subunit Orc2.	Histidine	44-54	protein serine/threonine kinase activating protein DBF4	Saccharomyces cerevisiae S288C	84-88
21488608-3	2011	This detection is based on the Mb-induced aggregation of IDA-functionalized AuNPs resulting from the structures of Mb sandwiched between the functionalized AuNPs via Cu(2+) bridges in the coordination interactions of IDA-Cu(2+)-histidine residues available on the Mb surface, which was confirmed by UV-vis spectroscopy, transmission electron microscopy, dynamic light scattering, and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.	Histidine	228-237	myoglobin	Homo sapiens	31-33
20353168-9	2010	YC-1 binding also strains the Fe-histidine bond, leading to a population of the five-coordinate sGC-CO complex in addition to a conformationally distinct population of the six-coordinate sGC-CO complex.	Histidine	33-42	RNA binding motif single stranded interacting protein 1	Homo sapiens	0-4
19697087-6	2010	Treatment of undeveloped ovarian explant cultures with recombinant histidine (His)-RPL10a stimulated the expression of translationally controlled tumor protein (TCTP), heat shock protein 70 (HSP70), and shrimp ovarian peritrophin (SOP) genes, previously shown to be involved in ovarian maturation.	Histidine	67-76	heat shock protein family A (Hsp70) member 4	Homo sapiens	168-189
19697087-6	2010	Treatment of undeveloped ovarian explant cultures with recombinant histidine (His)-RPL10a stimulated the expression of translationally controlled tumor protein (TCTP), heat shock protein 70 (HSP70), and shrimp ovarian peritrophin (SOP) genes, previously shown to be involved in ovarian maturation.	Histidine	67-76	heat shock protein family A (Hsp70) member 4	Homo sapiens	191-196
19697087-6	2010	Treatment of undeveloped ovarian explant cultures with recombinant histidine (His)-RPL10a stimulated the expression of translationally controlled tumor protein (TCTP), heat shock protein 70 (HSP70), and shrimp ovarian peritrophin (SOP) genes, previously shown to be involved in ovarian maturation.	Histidine	78-81	heat shock protein family A (Hsp70) member 4	Homo sapiens	168-189
19697087-6	2010	Treatment of undeveloped ovarian explant cultures with recombinant histidine (His)-RPL10a stimulated the expression of translationally controlled tumor protein (TCTP), heat shock protein 70 (HSP70), and shrimp ovarian peritrophin (SOP) genes, previously shown to be involved in ovarian maturation.	Histidine	78-81	heat shock protein family A (Hsp70) member 4	Homo sapiens	191-196
8457584-4	1993	The modified species was purified to apparent homogeneity and shown to arise from AIA-induced blockage of about 2 histidines in the cytochrome P-450LM2 molecule located close to the heme edge.	Histidine	114-124	cytochrome P450 2B4	Oryctolagus cuniculus	132-151
21488608-3	2011	This detection is based on the Mb-induced aggregation of IDA-functionalized AuNPs resulting from the structures of Mb sandwiched between the functionalized AuNPs via Cu(2+) bridges in the coordination interactions of IDA-Cu(2+)-histidine residues available on the Mb surface, which was confirmed by UV-vis spectroscopy, transmission electron microscopy, dynamic light scattering, and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.	Histidine	228-237	myoglobin	Homo sapiens	115-117
21488608-3	2011	This detection is based on the Mb-induced aggregation of IDA-functionalized AuNPs resulting from the structures of Mb sandwiched between the functionalized AuNPs via Cu(2+) bridges in the coordination interactions of IDA-Cu(2+)-histidine residues available on the Mb surface, which was confirmed by UV-vis spectroscopy, transmission electron microscopy, dynamic light scattering, and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.	Histidine	228-237	myoglobin	Homo sapiens	115-117
26610143-3	2011	The axial base oscillates between a His-on form in the Me-cob(III)lamin:MetH resting state, where the Co-N(His759) distance is 2.27 A, and a His-off form in the cob(I)alamin:MetH intermediate (2.78 A).	Histidine	36-39	metabolism of cobalamin associated B	Homo sapiens	58-61
8462973-5	1993	A guanine to cytosine substitution results in a missense mutation (asp147 to his) in the fourth repeat of the binding domain encoded by exon 4 of the LDL receptor gene.	Histidine	77-80	low density lipoprotein receptor	Homo sapiens	150-162
7916704-5	1993	Specifically, the aa sequence surrounding the proximal His residue, probably essential for TPO activity, is well conserved among these four organisms.	Histidine	55-58	thyroid peroxidase	Mus musculus	91-94
20050619-0	2010	Nonadiabatic histidine dissociation of hexacoordinate heme in neuroglobin protein.	Histidine	13-22	neuroglobin	Homo sapiens	62-73
20050619-1	2010	In the present work, density functional theory and canonical nonadiabatic Monte Carlo transition state theory have been used to investigate the histidine dissociation process from hexacoordinate heme in Ngb protein.	Histidine	144-153	neuroglobin	Homo sapiens	203-206
19793597-8	2010	The other was a novel missense mutation resulting in a substitution of Asn (AAC) for His (CAC) at codon 373 in exon 6 (H373N) on a paternal allele.	Histidine	85-88	glycine-N-acyltransferase	Homo sapiens	76-79
19486361-7	2010	RESULTS: The frequencies of ADH2 Arg/His genotype and of ADH2 His allele were significantly lower in patients with migraine when compared with those of controls, and were unrelated with the age of onset of migraine attacks, family history of migraine or presence of aura.	Histidine	37-40	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	28-32
21490302-8	2011	Resequencing analysis pinpointed the association to a histidine (basic amino acid) for aspartic acid (acidic amino acid) substitution in the encoded protein domain that defines GST substrate specificity and biochemical activity.	Histidine	54-63	glutathione S-transferase	Zea mays	177-180
19801650-3	2009	The 1,25D-hVDR structure-function studies demonstrate that 1) van der Waals contacts between helix-12 residues Leu-414 and Val-418 and 1,25D enhance the stability of the closed helix-12 conformer and 2) removal of the side-chain H-bonds to His-305(F) and/or His-397(F) have no effect on 1,25D transactivation, even though they reduce the binding affinity of 1,25D.	Histidine	240-243	vitamin D receptor	Homo sapiens	10-14
19801650-3	2009	The 1,25D-hVDR structure-function studies demonstrate that 1) van der Waals contacts between helix-12 residues Leu-414 and Val-418 and 1,25D enhance the stability of the closed helix-12 conformer and 2) removal of the side-chain H-bonds to His-305(F) and/or His-397(F) have no effect on 1,25D transactivation, even though they reduce the binding affinity of 1,25D.	Histidine	258-261	vitamin D receptor	Homo sapiens	10-14
8424781-2	1993	H-189 [Pro-His-Pro-Phe-His-Sta-(statyl)-Val-Ile-His-Lys] is an analogue of human angiotensinogen.	Histidine	11-14	GCY	Homo sapiens	27-30
1429633-1	1992	Recombinant human myoglobin mutants with the distal His residue (E7, His64) replaced by Leu, Val, or Gln residues were prepared by site-directed mutagenesis and expression in Escherichia coli.	Histidine	52-55	myoglobin	Homo sapiens	18-27
1429633-3	1992	Mutations, His--&gt;Val and His--&gt;Leu, remove the heme-bound water molecule resulting in a five-coordinate heme iron at neutral pH, while the heme-bound water molecule appears to be retained in the engineered myoglobin with His--&gt;Gln substitution as in the wild-type protein.	Histidine	11-14	myoglobin	Homo sapiens	212-221
1429633-3	1992	Mutations, His--&gt;Val and His--&gt;Leu, remove the heme-bound water molecule resulting in a five-coordinate heme iron at neutral pH, while the heme-bound water molecule appears to be retained in the engineered myoglobin with His--&gt;Gln substitution as in the wild-type protein.	Histidine	28-31	myoglobin	Homo sapiens	212-221
1429633-3	1992	Mutations, His--&gt;Val and His--&gt;Leu, remove the heme-bound water molecule resulting in a five-coordinate heme iron at neutral pH, while the heme-bound water molecule appears to be retained in the engineered myoglobin with His--&gt;Gln substitution as in the wild-type protein.	Histidine	28-31	myoglobin	Homo sapiens	212-221
21563331-0	2004	(68)Ga-DOTA-4-amino-1-carboxymethyl-piperidine-D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2 The amphibian bombesin (BBN or BN, a peptide of 14 amino acids) is an analog of human gastrin-releasing peptide (GRP, a peptide of 27 amino acids) that binds to GRP receptor (GRPR) with high affinity and specificity (1).	Histidine	73-76	GCY	Homo sapiens	77-80
19918057-6	2009	Despite the lack of a DFG motif, ATP binding to haspin is similar to that in classical kinases; however, the ATP gamma-phosphate forms hydrogen bonds with the conserved catalytic loop residues Asp-649 and His-651, and a His651Ala haspin mutant is inactive, suggesting a direct role for the catalytic loop in ATP recognition.	Histidine	205-208	histone H3 associated protein kinase	Homo sapiens	48-54
1400461-3	1992	Based on the close sequence homology with pancreatic lipase, both LPL and HL are believed to have a two-domain structure composed of an amino-terminal (NH2-terminal) domain containing the catalytic Ser-His-Asp triad and a smaller carboxyl-terminal (COOH-terminal) domain.	Histidine	202-205	lipoprotein lipase	Homo sapiens	66-69
21563331-12	2004	A DOTA-Gly-benzoyl group was added to the C-terminus to form DOTA-Gly-benzoyl-d-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2 (RM1).	Histidine	104-107	GCY	Homo sapiens	108-111
21277849-8	2011	Increased lysosomal histidine, in the absence of SLC15A4, appears to negatively regulate Toll-like receptor 9 function by inhibiting the proteolytic activities of cathepsins B and L. SLC15A4(-/-) mice also had a severe defect in NOD1-dependent cytokine production, indicating that SLC15A4 functions as a transporter of the NOD1 ligand.	Histidine	20-29	nucleotide-binding oligomerization domain containing 1	Mus musculus	229-233
19661212-6	2009	UGT2B7.1 (His(268)) and UGT2B7.2 (Tyr(268)) enzyme activity was similar, whereas UGT1A3.2 (R(11)A(47)), UGT1A3.3 (Trp(11)), and UGT1A9.3 (Thr(33)) showed 61 to 96% reduced V(max)/K(m) values compared with the respective (1) reference proteins.	Histidine	10-13	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	0-6
19903770-2	2009	The antiangiogenic properties of HRG are mediated via its proteolytically released histidine- and proline-rich (His/Pro-rich) domain.	Histidine	83-92	histidine rich glycoprotein	Homo sapiens	33-36
1517238-0	1992	Identification of essential histidine residues in rat type I iodothyronine deiodinase.	Histidine	28-37	iodothyronine deiodinase 1	Rattus norvegicus	54-85
21277849-8	2011	Increased lysosomal histidine, in the absence of SLC15A4, appears to negatively regulate Toll-like receptor 9 function by inhibiting the proteolytic activities of cathepsins B and L. SLC15A4(-/-) mice also had a severe defect in NOD1-dependent cytokine production, indicating that SLC15A4 functions as a transporter of the NOD1 ligand.	Histidine	20-29	nucleotide-binding oligomerization domain containing 1	Mus musculus	323-327
20623307-0	2011	Molecular modeling and dynamics simulation of a histidine-tagged cytochrome b5.	Histidine	48-57	cytochrome b5 type A	Homo sapiens	65-78
1512197-2	1992	ArcB belongs to a subclass of sensors that have not only a conserved histidine-containing transmitter domain but also a conserved aspartate-containing receiver domain of the regulator family.	Histidine	69-78	hypothetical protein	Escherichia coli	0-4
1512262-8	1992	With the switch region in an open position in the R2-state, His-97 beta 2 should be able to move by Thr-41 alpha 1 and make the transition to the T-state with a steric barrier that is less than that for the R-T transition.	Histidine	60-63	adrenoceptor alpha 1D	Homo sapiens	107-114
19726676-2	2009	To identify functional partners of ATF4, we applied ROS17/2.8 osteoblast nuclear extracts and purified recombinant His-ATF4 onto a Ni(+) affinity matrix chromatography column.	Histidine	115-118	activating transcription factor 4	Homo sapiens	119-123
19715344-8	2009	Taken together, our analytical, spectroscopic, and mutagenesis data indicate that Grx3/4 and Fra2 form a Fe-S-bridged heterodimeric complex with Fe ligands provided by the active site cysteine of Grx3/4, glutathione, and a histidine residue.	Histidine	223-232	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	82-88
19715344-8	2009	Taken together, our analytical, spectroscopic, and mutagenesis data indicate that Grx3/4 and Fra2 form a Fe-S-bridged heterodimeric complex with Fe ligands provided by the active site cysteine of Grx3/4, glutathione, and a histidine residue.	Histidine	223-232	Bol2p	Saccharomyces cerevisiae S288C	93-97
21317397-5	2011	Purification by anti-human kappa and anti-His-tag affinity, as well as size exclusion chromatography, resulted in a homogenous preparation of highly pure IgA dimers.	Histidine	42-45	immunoglobulin heavy variable 4-38-2-like	Homo sapiens	154-157
19715344-8	2009	Taken together, our analytical, spectroscopic, and mutagenesis data indicate that Grx3/4 and Fra2 form a Fe-S-bridged heterodimeric complex with Fe ligands provided by the active site cysteine of Grx3/4, glutathione, and a histidine residue.	Histidine	223-232	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	82-86
19851015-2	2009	An apo IL-3A dUTPase with an amino-terminal T7 epitope tag and a carboxy-terminal histidine tag yielded cubic P2(1)3 crystals with unit-cell parameter a = 106.65 A.	Histidine	82-91	Deoxyuridine triphosphatase	Drosophila melanogaster	13-20
1637185-0	1992	Site-directed mutagenesis of glutathione S-transferase YaYa: functional studies of histidine, cysteine, and tryptophan mutants.	Histidine	83-92	hematopoietic prostaglandin D synthase	Rattus norvegicus	29-54
1637185-1	1992	The rat cytosolic glutathione S-transferase Ya subunit contains three histidine residues (at positions 8, 143, and 159), two cysteine residues (at positions 18 and 112), and a single tryptophan residue (at position 21).	Histidine	70-79	hematopoietic prostaglandin D synthase	Rattus norvegicus	18-43
1637185-2	1992	Histidine, cysteine, and tryptophan have been proposed to be present either near or at the active site of other glutathione S-transferase subunits.	Histidine	0-9	hematopoietic prostaglandin D synthase	Rattus norvegicus	112-137
1637185-7	1992	These results indicate that histidine, cysteine, and tryptophan in the glutathione S-transferase Ya subunit are not essential for catalysis nor are they involved in the binding of heme to the YaYa homodimer.	Histidine	28-37	hematopoietic prostaglandin D synthase	Rattus norvegicus	71-96
21279630-3	2011	Among these, it was found that insertion of oxygen atoms occurred at histidine for HG and HGG, and both histidine and glycine for GH, GHG, and GGH.	Histidine	104-113	gamma-glutamyl hydrolase	Homo sapiens	143-146
1612770-2	1992	Data on partial characterization of GP110 suggest that it is a glycoprotein which is enriched in Lys, Glu, His, Leu, and Ala residues.	Histidine	107-110	ADRM1 26S proteasome ubiquitin receptor	Homo sapiens	36-41
19549924-0	2009	Heparan sulfate promotes the aggregation of HDL-associated serum amyloid A: evidence for a proamyloidogenic histidine molecular switch.	Histidine	108-117	serum amyloid A1 cluster	Homo sapiens	59-74
21290627-0	2004	3-Cyano-4-[(18)F]fluoro-benzoyl-Ala(SO3H)-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2 3-Cyano-4-[(18)F]fluoro-benzoyl-Ala(SO3H)-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2, abbreviated as [(18)F]7b, is a bombesin (BN)-based (18)F-labeled peptide synthesized by Mu et al.	Histidine	154-157	GCY	Homo sapiens	73-76
1620108-3	1992	GTR1 encodes a protein consisting of 310 amino acid residues containing, in its N-terminal region, the characteristic tripartite consensus elements for binding GTP conserved in GTP-binding proteins, except for histidine in place of a widely conserved aspargine residue in element III.	Histidine	210-219	Rag GTPase GTR1	Saccharomyces cerevisiae S288C	0-4
21290627-0	2004	3-Cyano-4-[(18)F]fluoro-benzoyl-Ala(SO3H)-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2 3-Cyano-4-[(18)F]fluoro-benzoyl-Ala(SO3H)-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2, abbreviated as [(18)F]7b, is a bombesin (BN)-based (18)F-labeled peptide synthesized by Mu et al.	Histidine	154-157	GCY	Homo sapiens	158-161
19666115-2	2009	As a strategy to identify TIMP-3 binding proteins, we used tandem affinity purification, employing recombinant adenoviruses constructed to deliver TIMP-3 fused to C-terminal S and His tags (TIMP-3-S-His) or TIMP-1-S-His control to endothelial cells prior to extraction.	Histidine	199-202	TIMP metallopeptidase inhibitor 3	Homo sapiens	26-32
19666115-2	2009	As a strategy to identify TIMP-3 binding proteins, we used tandem affinity purification, employing recombinant adenoviruses constructed to deliver TIMP-3 fused to C-terminal S and His tags (TIMP-3-S-His) or TIMP-1-S-His control to endothelial cells prior to extraction.	Histidine	199-202	TIMP metallopeptidase inhibitor 3	Homo sapiens	26-32
21117662-5	2011	There is also a contribution from the C-terminus in conjunction with the histidine at position 50 in alpha-synuclein and position 65 in beta-synuclein, although these regions appear to have little effect on overall coordination stability.	Histidine	73-82	synuclein alpha	Homo sapiens	101-116
19666192-1	2009	The tripeptide thyrotropin-releasing hormone (TRH, pGlu-His-Pro-NH2) has been shown to possess neuroprotective activity in in vitro and in vivo models.	Histidine	56-59	thyrotropin releasing hormone	Mus musculus	15-44
19666192-1	2009	The tripeptide thyrotropin-releasing hormone (TRH, pGlu-His-Pro-NH2) has been shown to possess neuroprotective activity in in vitro and in vivo models.	Histidine	56-59	thyrotropin releasing hormone	Mus musculus	46-49
1584790-8	1992	Although other possibilities are not excluded, it is suggested that the modification of histidine residues in proteins by HNE involves a Michael-type addition of the imidazole nitrogen atom of histidine to the alpha, beta-unsaturated bond of HNE, followed by secondary reaction involving the aldehyde group with the C-4 hydroxyl group of HNE.	Histidine	88-97	complement C4A (Rodgers blood group)	Homo sapiens	316-319
1584790-8	1992	Although other possibilities are not excluded, it is suggested that the modification of histidine residues in proteins by HNE involves a Michael-type addition of the imidazole nitrogen atom of histidine to the alpha, beta-unsaturated bond of HNE, followed by secondary reaction involving the aldehyde group with the C-4 hydroxyl group of HNE.	Histidine	193-202	complement C4A (Rodgers blood group)	Homo sapiens	316-319
20962270-0	2011	Structure-function activity of the human sodium-dependent multivitamin transporter: role of His&amp;#185;&amp;#185;&amp;#8309; and His254.	Histidine	92-95	solute carrier family 5 member 6	Homo sapiens	41-82
1577752-10	1992	The carboxyl-terminal domain of LacS contains 2 histidine residues (His-537 and His-552) that are conserved in seven homologous IIA protein(s) (domains) of PTSs.	Histidine	48-57	colicin Ia immunity protein	Escherichia coli	128-131
1577752-10	1992	The carboxyl-terminal domain of LacS contains 2 histidine residues (His-537 and His-552) that are conserved in seven homologous IIA protein(s) (domains) of PTSs.	Histidine	68-71	colicin Ia immunity protein	Escherichia coli	128-131
1577752-10	1992	The carboxyl-terminal domain of LacS contains 2 histidine residues (His-537 and His-552) that are conserved in seven homologous IIA protein(s) (domains) of PTSs.	Histidine	80-83	colicin Ia immunity protein	Escherichia coli	128-131
19272353-1	2009	The mitochondrial carnitine/acylcarnitine carrier (CAC) of Rattus norvegicus contains two His, His-29 and His-205.	Histidine	90-93	solute carrier family 25 member 20	Rattus norvegicus	4-55
19272353-1	2009	The mitochondrial carnitine/acylcarnitine carrier (CAC) of Rattus norvegicus contains two His, His-29 and His-205.	Histidine	95-98	solute carrier family 25 member 20	Rattus norvegicus	4-55
19272353-1	2009	The mitochondrial carnitine/acylcarnitine carrier (CAC) of Rattus norvegicus contains two His, His-29 and His-205.	Histidine	95-98	solute carrier family 25 member 20	Rattus norvegicus	4-55
19272353-3	2009	In the homology model of CAC, His-29 is located in H1 close to the bottom of the central cavity.	Histidine	30-33	solute carrier family 25 member 20	Rattus norvegicus	25-28
19272353-10	2009	The substitution of His-205 led to a change of response of the CAC to the pH.	Histidine	20-23	solute carrier family 25 member 20	Rattus norvegicus	63-66
19272353-11	2009	The results are discussed in terms of relationships of His-29 with the molecular mechanism of translocation of the CAC.	Histidine	55-58	solute carrier family 25 member 20	Rattus norvegicus	115-118
20962270-4	2011	Using site-directed mutagenesis approach, we examined the role of the positively charged histidine (His) residues of the human SMVT (hSMVT) in transporting the negatively charged biotin.	Histidine	89-98	solute carrier family 5 member 6	Homo sapiens	127-131
20962270-4	2011	Using site-directed mutagenesis approach, we examined the role of the positively charged histidine (His) residues of the human SMVT (hSMVT) in transporting the negatively charged biotin.	Histidine	89-98	solute carrier family 5 member 6	Homo sapiens	133-138
20962270-4	2011	Using site-directed mutagenesis approach, we examined the role of the positively charged histidine (His) residues of the human SMVT (hSMVT) in transporting the negatively charged biotin.	Histidine	100-103	solute carrier family 5 member 6	Homo sapiens	127-131
1353910-1	1992	The histidine residue at position 715 of elongation factor 2 (EF-2) is posttranslationally modified in a series of enzymatic reactions to 2-[3-carboxyamido-3-(trimethylammonio)-propyl]histidine, which has been given the trivial name diphthamide.	Histidine	4-13	eukaryotic translation elongation factor 2	Homo sapiens	62-66
19157633-8	2009	The polymorphism of XPG 46His/His was found to be associated with clinical response in NSCLC patients P=0.047, not detected between chemotherapy response and SNPs of XRCC1 399Arg/Gln or XPG 1104His/Asp (P=0.997 0.561, respectively).	Histidine	26-29	ERCC excision repair 5, endonuclease	Homo sapiens	20-23
20962270-4	2011	Using site-directed mutagenesis approach, we examined the role of the positively charged histidine (His) residues of the human SMVT (hSMVT) in transporting the negatively charged biotin.	Histidine	100-103	solute carrier family 5 member 6	Homo sapiens	133-138
19515935-5	2009	Although the histidine-tagged CTD (hCTD) was monomeric in solution, hCTD bound cooperatively to three of the recombination substrates (attB, attL and attR).	Histidine	13-22	transthyretin	Homo sapiens	150-154
1353910-3	1992	EF-2 that has not been posttranslationally modified at histidine 715 is resistant to ADP ribosylation by these toxins.	Histidine	55-64	eukaryotic translation elongation factor 2	Homo sapiens	0-4
20962270-5	2011	Of the seven conserved (across species) His residues in the hSMVT polypeptide, only His115 and His254 were found to be important for the function of hSMVT as their mutation led to a significant reduction in carrier-mediated biotin uptake.	Histidine	40-43	solute carrier family 5 member 6	Homo sapiens	60-65
1353910-4	1992	In this report we show that a G-to-A transition in the first position of codon 717 of the EF-2 gene results in substitution of arginine for glycine and prevents addition of the side chain of diphthamide to histidine 715 of EF-2.	Histidine	206-215	eukaryotic translation elongation factor 2	Homo sapiens	90-94
1353910-4	1992	In this report we show that a G-to-A transition in the first position of codon 717 of the EF-2 gene results in substitution of arginine for glycine and prevents addition of the side chain of diphthamide to histidine 715 of EF-2.	Histidine	206-215	eukaryotic translation elongation factor 2	Homo sapiens	223-227
20962270-5	2011	Of the seven conserved (across species) His residues in the hSMVT polypeptide, only His115 and His254 were found to be important for the function of hSMVT as their mutation led to a significant reduction in carrier-mediated biotin uptake.	Histidine	40-43	solute carrier family 5 member 6	Homo sapiens	149-154
19580749-4	2009	Histidine 328 in the S4 of Kv12.1 favors binding of Zn2+ and Cd2+, whereas the homologous residue Serine 321 in Kv10.2 contributes to effects of Mg2+ and Ni2+.	Histidine	0-9	potassium voltage-gated channel subfamily H member 8	Homo sapiens	27-33
21525719-7	2011	In conclusion, substitution with histidine leads to partial loss of inhibition of the mutant type I receptor through diminished binding of FKBP12, which may act as a gradient reader in morphogenetic contexts.	Histidine	33-42	FKBP prolyl isomerase 1A pseudogene 4	Homo sapiens	139-145
19568421-7	2009	Site-directed mutagenesis demonstrated that His(127), Asp(156) and Ser(263) in Domain 1 form the catalytic triad of EspP.	Histidine	44-47	extracellular serine protease (autotransporter)	Escherichia coli	116-120
1536576-4	1992	Isoelectric focusing and amino acid analysis of the differently loaded ferritins showed that ferrous ammonium sulfate loading of apoferritin resulted in the depletion of the basic amino acids, lysine and histidine, probably as a result of protein oxidation.	Histidine	204-213	ferritin heavy chain 1	Homo sapiens	129-140
20533040-1	2011	His(354) and His(358), two highly conserved histidines in Xenopus laevis (6-4) photolyase [equivalent to His(401) and His(405), in Dunaliella salina (6-4) photolyase], are critical for photoreactivation.	Histidine	0-3	6-4 photolyase	Xenopus laevis	74-89
1371284-4	1992	Based on primary sequence homology of LPL to pancreatic lipase, Ser-132, Asp-156, and His-241 have been proposed to be part of a domain required for normal enzymic activity.	Histidine	86-89	lipoprotein lipase	Homo sapiens	38-41
1371284-10	1992	These combined results strongly support the conclusion that Ser-132, Asp-156, and His-241 form the catalytic triad of LPL and are essential for LPL hydrolytic activity.	Histidine	82-85	lipoprotein lipase	Homo sapiens	118-121
1371284-10	1992	These combined results strongly support the conclusion that Ser-132, Asp-156, and His-241 form the catalytic triad of LPL and are essential for LPL hydrolytic activity.	Histidine	82-85	lipoprotein lipase	Homo sapiens	144-147
19419181-1	2009	We report the selective, controlled binding of a model redox probe, 1,1"-bis(N-imidazolylmethyl)ferrocene (Fc-Im2), and a small redox hemoprotein, histidine-tagged recombinant human neuroglobin (hNb), at the surface of metal electrodes (gold and SER-active silver) modified by a self-assembled monolayer (SAM) of a nitrilotriacetic (NTA)-terminated thiol.	Histidine	147-156	neuroglobin	Homo sapiens	182-193
18817875-10	2009	The result of mass spectrometry confirmed that the purified His-tagged DmUCH can recognize the ubiquitin-magainin fusion protein and cleave it at the carboxyl terminus of ubiquitin precisely.	Histidine	60-63	Ribosomal protein L40	Drosophila melanogaster	95-104
18817875-10	2009	The result of mass spectrometry confirmed that the purified His-tagged DmUCH can recognize the ubiquitin-magainin fusion protein and cleave it at the carboxyl terminus of ubiquitin precisely.	Histidine	60-63	Ribosomal protein L40	Drosophila melanogaster	171-180
1605801-1	1992	Preferable conformations of thyrotropin-releasing hormone (TRH, Glp-His-Pro-NH2) and its analogues Glp-Glu(R)-Pro-NH2 (R = NHCH(CH3)CH2Ar), Glp-Gln-Abu-NH2, Dho-Gln-Abu-NH2 in DMSO solution are determined using two-dimensional 1H NMR spectroscopy (delta-J-correlated, COSY and NOESY).	Histidine	68-71	euchromatic histone lysine methyltransferase 1	Homo sapiens	64-67
1605801-1	1992	Preferable conformations of thyrotropin-releasing hormone (TRH, Glp-His-Pro-NH2) and its analogues Glp-Glu(R)-Pro-NH2 (R = NHCH(CH3)CH2Ar), Glp-Gln-Abu-NH2, Dho-Gln-Abu-NH2 in DMSO solution are determined using two-dimensional 1H NMR spectroscopy (delta-J-correlated, COSY and NOESY).	Histidine	68-71	euchromatic histone lysine methyltransferase 1	Homo sapiens	99-102
20533040-1	2011	His(354) and His(358), two highly conserved histidines in Xenopus laevis (6-4) photolyase [equivalent to His(401) and His(405), in Dunaliella salina (6-4) photolyase], are critical for photoreactivation.	Histidine	0-3	6-4 photolyase	Xenopus laevis	150-165
1605801-1	1992	Preferable conformations of thyrotropin-releasing hormone (TRH, Glp-His-Pro-NH2) and its analogues Glp-Glu(R)-Pro-NH2 (R = NHCH(CH3)CH2Ar), Glp-Gln-Abu-NH2, Dho-Gln-Abu-NH2 in DMSO solution are determined using two-dimensional 1H NMR spectroscopy (delta-J-correlated, COSY and NOESY).	Histidine	68-71	euchromatic histone lysine methyltransferase 1	Homo sapiens	99-102
20533040-1	2011	His(354) and His(358), two highly conserved histidines in Xenopus laevis (6-4) photolyase [equivalent to His(401) and His(405), in Dunaliella salina (6-4) photolyase], are critical for photoreactivation.	Histidine	13-16	6-4 photolyase	Xenopus laevis	74-89
19351145-2	2009	The gold nanorod-bombesin (GNR-BBN) conjugates showed extraordinary in vitro stabilities against various biomolecules including NaCl, cysteine, histidine, bovine serum albumin, human serum albumin, and dithiothreitol.	Histidine	144-153	gastrin releasing peptide	Homo sapiens	17-25
20533040-1	2011	His(354) and His(358), two highly conserved histidines in Xenopus laevis (6-4) photolyase [equivalent to His(401) and His(405), in Dunaliella salina (6-4) photolyase], are critical for photoreactivation.	Histidine	44-54	6-4 photolyase	Xenopus laevis	74-89
19351145-2	2009	The gold nanorod-bombesin (GNR-BBN) conjugates showed extraordinary in vitro stabilities against various biomolecules including NaCl, cysteine, histidine, bovine serum albumin, human serum albumin, and dithiothreitol.	Histidine	144-153	gastrin releasing peptide	Homo sapiens	31-34
1730643-3	1992	Two genes (EFT1 and EFT2) were isolated by screening a bacteriophage lambda yeast genomic DNA library with an oligonucleotide probe complementary to the domain of EF-2 that contains diphthamide, the unique posttranslationally modified histidine that is specifically ADP-ribosylated by diphtheria toxin.	Histidine	235-244	elongation factor 2	Saccharomyces cerevisiae S288C	20-24
1730643-3	1992	Two genes (EFT1 and EFT2) were isolated by screening a bacteriophage lambda yeast genomic DNA library with an oligonucleotide probe complementary to the domain of EF-2 that contains diphthamide, the unique posttranslationally modified histidine that is specifically ADP-ribosylated by diphtheria toxin.	Histidine	235-244	elongation factor 2	Saccharomyces cerevisiae S288C	163-167
1730643-9	1992	In addition, yeast and mammalian EF-2 share identical sequences at two critical functional sites: (i) the domain containing the histidine residue that is modified to diphthamide and (ii) the threonine residue that is specifically phosphorylated in vivo in mammalian cells by calmodulin-dependent protein kinase III, also known as EF-2 kinase.	Histidine	128-137	eukaryotic translation elongation factor 2	Homo sapiens	33-37
20533040-1	2011	His(354) and His(358), two highly conserved histidines in Xenopus laevis (6-4) photolyase [equivalent to His(401) and His(405), in Dunaliella salina (6-4) photolyase], are critical for photoreactivation.	Histidine	13-16	6-4 photolyase	Xenopus laevis	74-89
20533040-1	2011	His(354) and His(358), two highly conserved histidines in Xenopus laevis (6-4) photolyase [equivalent to His(401) and His(405), in Dunaliella salina (6-4) photolyase], are critical for photoreactivation.	Histidine	13-16	6-4 photolyase	Xenopus laevis	74-89
22110750-5	2011	The data showed that SENP8 only cleaved the peptide bond beyond the di-glycine motif of CrNEDD8 and His-RUB1 was subsequently generated, confirming that SENP8 has exquisite specificity for CrNEDD8 but not CrUb.	Histidine	100-103	related to ubiquitin 1	Arabidopsis thaliana	104-108
19552893-9	2009	Moreover, our transgenic assays demonstrate that the N-terminus of the mosquito REL2, which includes the His/Gln-rich and serine-rich regions, plays a role in its transactivation properties.	Histidine	105-108	nuclear factor NF-kappa-B p110 subunit	Aedes aegypti	80-84
21179510-5	2010	We also discovered that the central proline-rich and histidine-rich domain of HD-PTP is responsible for these interactions.	Histidine	53-62	protein tyrosine phosphatase non-receptor type 23	Homo sapiens	78-84
19135030-2	2009	Amino-acid sequencing analysis reveals that meprin A and meprin alpha cleave pro-IL-1beta at the His(115)-Asp(116) bond, which is one amino acid N-terminal to the caspase-1 cleavage site and five amino acids C-terminal to the meprin beta site.	Histidine	97-100	meprin 1 alpha	Mus musculus	44-52
19135030-2	2009	Amino-acid sequencing analysis reveals that meprin A and meprin alpha cleave pro-IL-1beta at the His(115)-Asp(116) bond, which is one amino acid N-terminal to the caspase-1 cleavage site and five amino acids C-terminal to the meprin beta site.	Histidine	97-100	meprin 1 alpha	Mus musculus	57-69
1755856-0	1991	Non-essentiality of cysteine and histidine residues for the activity of human class PI glutathione S-transferase.	Histidine	33-42	glutathione S-transferase kappa 1	Homo sapiens	87-112
1932031-1	1991	We have applied site-directed mutagenesis methods to change the conserved tryptophan-22 in the substrate binding site of Escherichia coli dihydrofolate reductase to phenylalanine (W22F) and histidine (W22H).	Histidine	190-199	Dihydrofolate reductase	Escherichia coli	138-161
20876538-7	2010	The C-terminal region of DGAT1, which accounts for ~50% of the protein, is present in the endoplasmic reticulum lumen and contains a highly conserved histidine residue (His-426) that may be part of the active site.	Histidine	150-159	diacylglycerol O-acyltransferase 1	Mus musculus	25-30
19199251-5	2009	RESULTS: A missense mutation of GAT>CAT was identified at codon 1441 of the COL1A1 gene from the family, which resulted in the replacement of aspartic acid by histidine (D1441H).	Histidine	159-168	collagen type I alpha 1 chain	Homo sapiens	76-82
19139268-2	2009	Using a heterologous expression cloning approach, we isolated beta4GalNAcTB together with beta4GalNAcTB pilot (GABPI), a multimembrane-spanning protein related to Asp-His-His-Cys (DHHC) proteins but lacking the DHHC consensus sequence.	Histidine	167-170	beta1,4-N-acetylgalactosaminyltransferase B	Drosophila melanogaster	62-75
19139268-2	2009	Using a heterologous expression cloning approach, we isolated beta4GalNAcTB together with beta4GalNAcTB pilot (GABPI), a multimembrane-spanning protein related to Asp-His-His-Cys (DHHC) proteins but lacking the DHHC consensus sequence.	Histidine	167-170	beta1,4-N-acetylgalactosaminyltransferase B	Drosophila melanogaster	90-103
20876538-7	2010	The C-terminal region of DGAT1, which accounts for ~50% of the protein, is present in the endoplasmic reticulum lumen and contains a highly conserved histidine residue (His-426) that may be part of the active site.	Histidine	169-172	diacylglycerol O-acyltransferase 1	Mus musculus	25-30
18848840-8	2008	In the smoking group, there was a 0.15-fold (OR(adj), 0.15; 95% CI, 0.03-0.68; P=0.01) decreased risk of CBP for subjects carrying genotypes of hMYH 324His/Gln+Gln/Gln compared with those of genotype of hMYH 324His/His.	Histidine	152-155	mutY DNA glycosylase	Homo sapiens	144-148
21060845-5	2010	Here we report that an S. cerevisiae strain expressing the mre11-H59A allele, mutant at a conserved active site histidine, is sensitive to hydroxyurea and also to ionizing radiation, which induces DSBs, but not to CPT or ETP.	Histidine	112-121	MRX complex nuclease subunit	Saccharomyces cerevisiae S288C	59-64
19012067-8	2008	Kinetic data of the present study supported our recently published findings [using single step-solid phase radioimmunoassay (SS-SPRIA)] that the core region of hCGbeta epitope consists of Arg (94,95) and Asp (99) while a Lys (104) and a His (106) are in proximity to the core epitopic region.	Histidine	237-240	chorionic gonadotropin subunit beta 3	Homo sapiens	160-167
1789003-6	1991	This electroporation-stimulated recombination is abolished in an isogenic rad52 mutant strain consistent with the increase in Trp+ and His+ prototrophs being the result of a stimulation of a RAD52-dependent recombination pathway.	Histidine	135-138	recombinase RAD52	Saccharomyces cerevisiae S288C	74-79
1789003-6	1991	This electroporation-stimulated recombination is abolished in an isogenic rad52 mutant strain consistent with the increase in Trp+ and His+ prototrophs being the result of a stimulation of a RAD52-dependent recombination pathway.	Histidine	135-138	recombinase RAD52	Saccharomyces cerevisiae S288C	191-196
1918058-0	1991	Are the histidine residues of glutathione S-transferase important in catalysis?	Histidine	8-17	hematopoietic prostaglandin D synthase	Rattus norvegicus	30-55
1918058-2	1991	To test the proposition that a histidine residue is essential in the catalytic mechanism of glutathione S-transferase, rat liver isoenzyme 3-3 specifically labeled with [ring-2-13C]histidine was prepared.	Histidine	31-40	hematopoietic prostaglandin D synthase	Rattus norvegicus	92-117
20818390-3	2010	Like the bacterial enzyme, Mesh1 proteins contain an active site for ppGpp hydrolysis and a conserved His-Asp-box motif for Mn(2+) binding.	Histidine	102-105	Metazoan SpoT homolog-1	Drosophila melanogaster	27-32
1778982-0	1991	Substrate-selective activation of histidine-modified porcine pancreatic alpha-amylase by chloride ion.	Histidine	34-43	amylase alpha 2A	Homo sapiens	61-85
1778982-2	1991	By the modification of histidine residues of porcine pancreatic alpha-amylase with diethylpyrocarbonate (DEP), both amylase and maltosidase activities were decreased in the absence of chloride ion.	Histidine	23-32	amylase alpha 2A	Homo sapiens	53-77
18808205-0	2008	The effect of histidine residue modification on tyrosinase activity and conformation: inhibition kinetics and computational prediction.	Histidine	14-23	tyrosinase	Homo sapiens	48-58
18808205-1	2008	We found that the histidine chemical modification of tyrosinase conspicuously inactivated enzyme activity.	Histidine	18-27	tyrosinase	Homo sapiens	53-63
18808205-7	2008	The computational prediction was informative to elucidate the role of free histidine residues at the active site, which are related to substrate accessibility during tyrosinase catalysis.	Histidine	75-84	tyrosinase	Homo sapiens	166-176
20338153-15	2010	Determination of the three-dimensional structure of BChE and AChE conjugated to different OPs showed that aged adducts form a salt bridge with the protonated catalytic histidine.	Histidine	168-177	butyrylcholinesterase	Homo sapiens	52-56
18937046-4	2008	We have expressed the mature form of human DMGDH and the H109R variant identified in a DMGDH-deficient patient as N-terminally His(6)-tagged proteins in E. coli.	Histidine	127-130	dimethylglycine dehydrogenase	Homo sapiens	43-48
18641072-2	2008	In the absence of exogenous ligands, the ferric and the ferrous forms of Ngb are both hexacoordinated to the distal and proximal histidines.	Histidine	129-139	neuroglobin	Homo sapiens	73-76
1665895-3	1991	Furthermore actinomycin D was able to displace [125I]-His-NKA from NK2 receptor sites of the rat small intestine smooth muscle membranes.	Histidine	54-57	Natural killer alloreactivity QTL 1	Rattus norvegicus	58-61
20805576-13	2010	Several mutations of a histidine residue (H497) that is homologous to a histidine that is responsible for H(+) block in ClC-2 did not yield functional channels.	Histidine	23-32	chloride voltage-gated channel 2	Homo sapiens	120-125
1922698-4	1991	The substitution of His at position 3 and Leu at position 9 of GRP-10 by Leu and Phe, as in NMB leads to a decrease in activity.	Histidine	20-23	neuromedin B	Rattus norvegicus	92-95
18815197-6	2008	The molecular modeling suggests that the replacement of the N41 with a histidine (N41H) drastically disturbs the structure of the first portion of GPIbalpha N-terminal, directly involved in von Willebrand factor binding.	Histidine	71-80	glycoprotein Ib platelet subunit alpha	Homo sapiens	147-156
18767117-4	2008	Surprisingly, Lys, His, and Thr inhibited S6K1 phosphorylation in both murine and bovine mammary cells.	Histidine	19-22	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	42-46
2037591-11	1991	The cadherin cell adhesion recognition sequence (His-Ala-Val) is replaced by Phe-Ala-Thr, suggesting that DGII/III may be adhesive molecules using a different mechanism.	Histidine	49-52	desmocollin 2	Homo sapiens	106-114
20805576-13	2010	Several mutations of a histidine residue (H497) that is homologous to a histidine that is responsible for H(+) block in ClC-2 did not yield functional channels.	Histidine	72-81	chloride voltage-gated channel 2	Homo sapiens	120-125
1711024-11	1991	This protein is highly homologous with the AroP (general aromatic transport) system of E. coli (59.6% identity) and to a lesser extent with the yeast permeases CAN1 (arginine), PUT4 (proline), and HIP1 (histidine) of Saccharomyces cerevisiae.	Histidine	203-212	histidine permease	Saccharomyces cerevisiae S288C	197-201
18656488-1	2008	We have analyzed the role of individual heme-ligating histidine residues for assembly of holo-cytochrome b(6), and we show that the two hemes b(L) and b(H) bind in two subsequent steps to the apo-protein.	Histidine	54-63	mitochondrially encoded cytochrome b	Homo sapiens	94-106
20519567-0	2010	The role of the methionines and histidines in the transmembrane domain of mammalian copper transporter 1 in the cellular accumulation of cisplatin.	Histidine	32-42	solute carrier family 31 member 1	Homo sapiens	84-104
18707164-3	2008	The specific residues of MDM2 that have dominant binding interactions with p53 are specifically identified to be (51)Lys, (54)Leu, (62)Met, (67)Tyr, (72)Gln, (94)Lys, (96)His, and (100)Tyr.	Histidine	171-174	MDM2 proto-oncogene	Homo sapiens	25-29
20519567-2	2010	Methionines 150, 154, and histidine 139 have been proposed to form a series of stacked rings in the pore formed by the CTR1 homotrimer, each of which is required for maximal copper transport.	Histidine	26-35	solute carrier family 31 member 1	Homo sapiens	119-123
18690709-0	2008	Direct evidence that all three histidine residues coordinate to Cu(II) in amyloid-beta1-16.	Histidine	31-40	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	82-90
1681125-2	1991	A mitochondrial DNA (mtDNA) replacement mutation in LHON patient, G to A transition at nucleotide position (nt) 11778 converting the 340th arginine to histidine in the NADH dehydrogenase subunit 4, was detected as SfaNI site polymorphism (Wallace et al., Science, 242: 1427-1430, 1988).	Histidine	151-160	mitochondrially encoded NADH dehydrogenase 4	Homo sapiens	168-196
18690709-1	2008	We provide direct evidence that all three histidine residues in amyloid-beta 1-16 (Abeta 1-16) coordinate to Cu(II).	Histidine	42-51	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	72-81
20599753-12	2010	The active site of the catalytic domain of GBBH is similar to that of other 2KG oxygenases, and Fe(II)-binding residues form a conserved His-X-Asp-X(n)-His triad, which is found in all related enzymes.	Histidine	152-155	gamma-butyrobetaine hydroxylase 1	Homo sapiens	43-47
20361220-3	2010	Previous studies suggested that the first step of the dioxygenase reaction involves the deprotonation of the indoleamine group of the substrate by an evolutionarily conserved distal histidine residue in TDO and the heme-bound dioxygen in IDO.	Histidine	182-191	indoleamine 2,3-dioxygenase 1	Homo sapiens	238-241
18381743-4	2008	For SF2 chemical ligation made use of the histidine and the cysteine residues located in positions 41 and 42 of the native sequence, respectively, to afford a highly efficient synthesis of SF2 compared to the standard SPPS elongation method.	Histidine	42-51	serine and arginine rich splicing factor 1	Homo sapiens	4-7
18381743-4	2008	For SF2 chemical ligation made use of the histidine and the cysteine residues located in positions 41 and 42 of the native sequence, respectively, to afford a highly efficient synthesis of SF2 compared to the standard SPPS elongation method.	Histidine	42-51	serine and arginine rich splicing factor 1	Homo sapiens	189-192
1837452-1	1991	Histidine-containing peptides SHLRKV and DHTLIR, corresponding to placental anticoagulant protein-I (PAP-I) residues 204-209 and 266-271, respectively, are included in the functional site of PAP-I and exhibit anticoagulant activity, but the peptides in which alanine is substituted for histidine do not.	Histidine	0-9	annexin A5	Homo sapiens	66-99
1837452-1	1991	Histidine-containing peptides SHLRKV and DHTLIR, corresponding to placental anticoagulant protein-I (PAP-I) residues 204-209 and 266-271, respectively, are included in the functional site of PAP-I and exhibit anticoagulant activity, but the peptides in which alanine is substituted for histidine do not.	Histidine	0-9	annexin A5	Homo sapiens	101-106
1837452-1	1991	Histidine-containing peptides SHLRKV and DHTLIR, corresponding to placental anticoagulant protein-I (PAP-I) residues 204-209 and 266-271, respectively, are included in the functional site of PAP-I and exhibit anticoagulant activity, but the peptides in which alanine is substituted for histidine do not.	Histidine	0-9	annexin A5	Homo sapiens	191-196
1837452-1	1991	Histidine-containing peptides SHLRKV and DHTLIR, corresponding to placental anticoagulant protein-I (PAP-I) residues 204-209 and 266-271, respectively, are included in the functional site of PAP-I and exhibit anticoagulant activity, but the peptides in which alanine is substituted for histidine do not.	Histidine	286-295	annexin A5	Homo sapiens	66-99
1837452-1	1991	Histidine-containing peptides SHLRKV and DHTLIR, corresponding to placental anticoagulant protein-I (PAP-I) residues 204-209 and 266-271, respectively, are included in the functional site of PAP-I and exhibit anticoagulant activity, but the peptides in which alanine is substituted for histidine do not.	Histidine	286-295	annexin A5	Homo sapiens	101-106
1837452-1	1991	Histidine-containing peptides SHLRKV and DHTLIR, corresponding to placental anticoagulant protein-I (PAP-I) residues 204-209 and 266-271, respectively, are included in the functional site of PAP-I and exhibit anticoagulant activity, but the peptides in which alanine is substituted for histidine do not.	Histidine	286-295	annexin A5	Homo sapiens	191-196
1837452-3	1991	These findings thus suggest that His-205 and His-267 are involved in the Ca(2+)- or the phospholipid-binding site of PAP-I but that His-98 is not.	Histidine	33-36	annexin A5	Homo sapiens	117-122
20347988-4	2010	A new protocol has been developed for expression and purification of S. cerevisiae Hop1 protein, based on the presence of hexa-histidine tag and double-stranded DNA-Cellulose chromatography.	Histidine	127-136	Hop1p	Saccharomyces cerevisiae S288C	83-87
1837452-3	1991	These findings thus suggest that His-205 and His-267 are involved in the Ca(2+)- or the phospholipid-binding site of PAP-I but that His-98 is not.	Histidine	45-48	annexin A5	Homo sapiens	117-122
1837452-3	1991	These findings thus suggest that His-205 and His-267 are involved in the Ca(2+)- or the phospholipid-binding site of PAP-I but that His-98 is not.	Histidine	45-48	annexin A5	Homo sapiens	117-122
1705996-3	1991	Three different mutations at residue 402 (Asp to Glu, Asn, or His) totally prevented the formation of stable complexes with the cellular protein p53 in monkey cells but had no effect on virus replication.	Histidine	62-65	transformation related protein 53, pseudogene	Mus musculus	145-148
18582542-7	2008	Moreover, the reduced cytotoxicity noted with BPB-PLA2 may be partly attributed to conformational distortion after modification of His-47.	Histidine	131-134	phospholipase A2 group IIA	Homo sapiens	50-54
18627314-1	2008	Azurocidin belongs to the serprocidin family, but it is devoid of proteolytic activity due to a substitution of His and Ser residues in the catalytic triad.	Histidine	112-115	azurocidin 1	Homo sapiens	0-10
18627314-6	2008	The first isoleucine present in mature azurocidin can be replaced by similar amino acids, such as leucine or valine, but its substitution by histidine or arginine decreases proteolytic activity.	Histidine	141-150	azurocidin 1	Homo sapiens	39-49
2069873-8	1991	vav proteins also possess a cysteine-rich domain whose sequence predicts the formation of two putative metal binding-like domains, Cys-X2-Cys-X13-Cys-X2-Cys and His-X2-Cys-X6-Cys-X2-His.	Histidine	161-164	vav 1 oncogene	Mus musculus	0-3
20598110-2	2010	Comparison of the substrate-binding site of PRCP with that of its family partner, dipeptidyl dipeptidase 7 (DPP7), helps to explain the different enzymatic activities of these structurally similar proteins, and also reveals a novel apparent charge-relay system in PRCP involving the active-site catalytic histidine.	Histidine	305-314	dipeptidyl peptidase 7	Homo sapiens	93-106
2069873-8	1991	vav proteins also possess a cysteine-rich domain whose sequence predicts the formation of two putative metal binding-like domains, Cys-X2-Cys-X13-Cys-X2-Cys and His-X2-Cys-X6-Cys-X2-His.	Histidine	182-185	vav 1 oncogene	Mus musculus	0-3
18467498-6	2008	This vector produces a fusion protein (denoted as His(6)-Smt3-X) in which the protein of interest (X) is fused to a hexahistidine (His(6))-tagged Smt3.	Histidine	50-53	SUMO family protein SMT3	Saccharomyces cerevisiae S288C	57-61
18467498-6	2008	This vector produces a fusion protein (denoted as His(6)-Smt3-X) in which the protein of interest (X) is fused to a hexahistidine (His(6))-tagged Smt3.	Histidine	50-53	SUMO family protein SMT3	Saccharomyces cerevisiae S288C	146-150
18523251-6	2008	The lysine-free HIV-1 Nef mutant (Delta10K) generated by replacing all 10 lysines with arginines was not ubiquitinated and the major ubiquitin-His attachment sites in HIV-1 Nef were determined to be lysine 144 (di-ubiquitinated) and lysine 204 (mono-ubiquitinated).	Histidine	143-146	Nef	Human immunodeficiency virus 1	22-25
20598110-2	2010	Comparison of the substrate-binding site of PRCP with that of its family partner, dipeptidyl dipeptidase 7 (DPP7), helps to explain the different enzymatic activities of these structurally similar proteins, and also reveals a novel apparent charge-relay system in PRCP involving the active-site catalytic histidine.	Histidine	305-314	dipeptidyl peptidase 7	Homo sapiens	108-112
20534569-6	2010	Comparison with previously reported data for denatured state His-heme loop formation for iso-1-cytochrome c and Rhodopseudomonas palustris cytochrome c", shows that foldable sequences deviate significantly from random coil behavior and that the deviation is fold-dependent.	Histidine	61-64	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	89-94
18386080-3	2008	The protein shows unprecedented properties within the cytochrome c (4) family, including (1) an almost nonpolar surface charge distribution, (2) the absence of high-spin heme Fe(III) states, indicative of a thermodynamically stable and kinetically inert axial heme His,Met coordination, and (3) identical E degrees " values for the two heme centers (+0.322 V vs the standard hydrogen elecrode).	Histidine	265-268	PSHA_RS13535	Pseudoalteromonas haloplanktis TAC125	54-66
20202940-5	2010	Wild-type untagged Ste14p also co-immunoprecipitated and co-purified with N-terminal-tagged His(10)-myc(3)-Ste14p (His-Ste14p).	Histidine	92-95	protein-S-isoprenylcysteine carboxyl O-methyltransferase	Saccharomyces cerevisiae S288C	19-25
18497940-2	2008	Structural analysis showed that Nbla10993 is a novel splicing variant of the ER-associated protein of 140 kDa (ERAP140), which lacks the central acidic as well as the COOH-terminal Cys/His-rich domain.	Histidine	185-188	nuclear receptor coactivator 7	Homo sapiens	32-41
18497940-2	2008	Structural analysis showed that Nbla10993 is a novel splicing variant of the ER-associated protein of 140 kDa (ERAP140), which lacks the central acidic as well as the COOH-terminal Cys/His-rich domain.	Histidine	185-188	nuclear receptor coactivator 7	Homo sapiens	77-109
18497940-2	2008	Structural analysis showed that Nbla10993 is a novel splicing variant of the ER-associated protein of 140 kDa (ERAP140), which lacks the central acidic as well as the COOH-terminal Cys/His-rich domain.	Histidine	185-188	nuclear receptor coactivator 7	Homo sapiens	111-118
20202940-5	2010	Wild-type untagged Ste14p also co-immunoprecipitated and co-purified with N-terminal-tagged His(10)-myc(3)-Ste14p (His-Ste14p).	Histidine	92-95	protein-S-isoprenylcysteine carboxyl O-methyltransferase	Saccharomyces cerevisiae S288C	107-113
20202940-5	2010	Wild-type untagged Ste14p also co-immunoprecipitated and co-purified with N-terminal-tagged His(10)-myc(3)-Ste14p (His-Ste14p).	Histidine	92-95	protein-S-isoprenylcysteine carboxyl O-methyltransferase	Saccharomyces cerevisiae S288C	107-113
20202940-5	2010	Wild-type untagged Ste14p also co-immunoprecipitated and co-purified with N-terminal-tagged His(10)-myc(3)-Ste14p (His-Ste14p).	Histidine	115-118	protein-S-isoprenylcysteine carboxyl O-methyltransferase	Saccharomyces cerevisiae S288C	19-25
18345016-2	2008	Here we report that two histidine residues, His365 and His394, located in the intracellular regulator of conductance for K+ (RCK) 1 domain, serve as the H+ sensors of the SLO1 BK channel.	Histidine	24-33	potassium calcium-activated channel subfamily M alpha 1	Homo sapiens	171-175
20202940-5	2010	Wild-type untagged Ste14p also co-immunoprecipitated and co-purified with N-terminal-tagged His(10)-myc(3)-Ste14p (His-Ste14p).	Histidine	115-118	protein-S-isoprenylcysteine carboxyl O-methyltransferase	Saccharomyces cerevisiae S288C	107-113
18178100-8	2008	FRET analysis showed that his-ACBP directly interacted with HNF-4alpha (intermolecular distance of 73 A) at high affinity (K(d)=64-111 nM) similar to native ACBP.	Histidine	26-29	hepatic nuclear factor 4, alpha	Mus musculus	60-70
20202940-5	2010	Wild-type untagged Ste14p also co-immunoprecipitated and co-purified with N-terminal-tagged His(10)-myc(3)-Ste14p (His-Ste14p).	Histidine	115-118	protein-S-isoprenylcysteine carboxyl O-methyltransferase	Saccharomyces cerevisiae S288C	107-113
20202940-6	2010	Furthermore, enzymatically inactive His-Ste14p variants L81F and E213Q both exerted a dominant-negative effect on methyltransferase activity when co-expressed and co-purified with untagged wild-type Ste14p.	Histidine	36-39	protein-S-isoprenylcysteine carboxyl O-methyltransferase	Saccharomyces cerevisiae S288C	40-46
20202940-6	2010	Furthermore, enzymatically inactive His-Ste14p variants L81F and E213Q both exerted a dominant-negative effect on methyltransferase activity when co-expressed and co-purified with untagged wild-type Ste14p.	Histidine	36-39	protein-S-isoprenylcysteine carboxyl O-methyltransferase	Saccharomyces cerevisiae S288C	199-205
20374851-2	2010	We have shown that myosin is soluble in a low ionic strength solution containing L-histidine.	Histidine	81-92	myosin heavy chain 14	Homo sapiens	19-25
18316727-5	2008	The stimulatory action of CO on the Slo1 BK channel requires an aspartic acid and two histidine residues located in the cytoplasmic RCK1 domain, and the effect persists under the conditions known to inhibit the conventional interaction between CO and heme in other proteins.	Histidine	86-95	potassium calcium-activated channel subfamily M alpha 1	Homo sapiens	36-40
20374851-0	2010	Myosin filament depolymerizes in a low ionic strength solution containing L-histidine.	Histidine	74-85	myosin heavy chain 14	Homo sapiens	0-6
20641835-2	2004	Both GRP and BN share an amidated C-terminus sequence homology of seven amino acids, -Trp-Ala-Val-Gly-His-Leu-Met-NH2.	Histidine	102-105	gastrin releasing peptide	Homo sapiens	5-8
20374851-3	2010	In this study, to clarify the role of L-histidine in the solubilization of myosin, we investigated effects of L-histidine on the filament formation and the morphology of myosin at a low ionic strength.	Histidine	38-49	myosin heavy chain 14	Homo sapiens	75-81
20374851-4	2010	In the presence of L-histidine, myosin formed a filamentous polymer in a physiological ionic strength solution and dispersed in a low ionic strength solution.	Histidine	19-30	myosin heavy chain 14	Homo sapiens	32-38
20374851-5	2010	Transmission electron microscopy showed that light meromyosin (LMM), the rod region of myosin, in a low ionic strength solution containing L-histidine was longer than that in a high ionic strength solution without L-histidine.	Histidine	139-150	myosin heavy chain 14	Homo sapiens	55-61
20374851-6	2010	L-histidine causes the elongation of LMM region of myosin contributing to the weakening of the myosin filament and the dissociation of myosin in a low ionic strength solution.	Histidine	0-11	myosin heavy chain 14	Homo sapiens	51-57
17523919-2	2008	DRR1 from Homo sapiens was cloned into the pQE30 vector for fusion-protein expression with six histidine residues in Escherichia coli BL21(DE3).	Histidine	95-104	family with sequence similarity 107 member A	Homo sapiens	0-4
20374851-6	2010	L-histidine causes the elongation of LMM region of myosin contributing to the weakening of the myosin filament and the dissociation of myosin in a low ionic strength solution.	Histidine	0-11	myosin heavy chain 14	Homo sapiens	95-101
20368108-6	2010	Firstly RT-PCR and Western blot results showed that the expression of TAP in GES-1 cells was increased after pcDNA3.1/V5-His-TAP1 transfection.	Histidine	121-124	filamin B	Homo sapiens	70-73
17936057-6	2008	Interestingly, the interaction of both isoforms with Shp2 in vivo was found using stable cell lines expressing eEF1A1-His or eEF1A2-His.	Histidine	118-121	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	53-57
20371992-8	2010	Zn(II) binds to the N(tau) atom of histidine and the peptide aggregates through intermolecular His-Zn-His bridges.	Histidine	35-44	microtubule associated protein tau	Homo sapiens	22-25
17936057-6	2008	Interestingly, the interaction of both isoforms with Shp2 in vivo was found using stable cell lines expressing eEF1A1-His or eEF1A2-His.	Histidine	132-135	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	53-57
17956868-8	2007	Replacing Pro-40 of UGT1A4 by histidine expanded the glucuronidation activity of the enzyme to phenolic and carboxylic compounds, therefore, leading to UGT1A3-type isoform in terms of substrate specificity.	Histidine	30-39	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	152-158
17956868-9	2007	Conversely, when His-40 residue of UGT1A3 was replaced with proline, the substrate specificity shifted toward that of UGT1A4 with loss of glucuronidation of phenolic substrates.	Histidine	17-20	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	35-41
17956868-10	2007	Furthermore, mutation of His-39 residue of UGT1A1 (His-40 in UGT1A4) to proline led to loss of glucuronidation of phenols but not of estrogens.	Histidine	25-28	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	43-49
20371992-8	2010	Zn(II) binds to the N(tau) atom of histidine and the peptide aggregates through intermolecular His-Zn-His bridges.	Histidine	95-98	microtubule associated protein tau	Homo sapiens	22-25
17956868-10	2007	Furthermore, mutation of His-39 residue of UGT1A1 (His-40 in UGT1A4) to proline led to loss of glucuronidation of phenols but not of estrogens.	Histidine	51-54	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	43-49
20371992-8	2010	Zn(II) binds to the N(tau) atom of histidine and the peptide aggregates through intermolecular His-Zn-His bridges.	Histidine	102-105	microtubule associated protein tau	Homo sapiens	22-25
19828673-2	2010	In adult ventricular cell pairs, localized cellular pHi disturbances are removed by sarcolemmal acid/base transporters, but can also be dissipated (diluted) across gap junctions, aboard mobile buffers such as CO2/HCO3- and histidine-containing dipeptides (HCDPs).	Histidine	223-232	glucose-6-phosphate isomerase	Rattus norvegicus	52-55
17928348-5	2007	We identify an invariant series of six cysteine and histidine residues in the CTD of G2 that is essential for incorporation of SSP in the GP-C complex.	Histidine	52-61	glycophorin C (Gerbich blood group)	Homo sapiens	138-142
19319663-2	2010	Using this system, we recently reported the overproduction of histidine-tagged mouse estrogen receptor (ER) alpha-ligand binding domain as an intact 30 kD protein and its inhibitory effect on the growth of bacteria.	Histidine	62-71	estrogen receptor 1 (alpha)	Mus musculus	85-102
17686524-2	2007	To gain insight into the importance of the heme hexacoordination and the coordinated distal histidine in general for the possible physiological functions of these proteins, the distal His(E7) of Arabidopsis thaliana hemoglobin (AHb1) was substituted by a leucine residue.	Histidine	184-187	hemoglobin 1	Arabidopsis thaliana	216-226
19319663-2	2010	Using this system, we recently reported the overproduction of histidine-tagged mouse estrogen receptor (ER) alpha-ligand binding domain as an intact 30 kD protein and its inhibitory effect on the growth of bacteria.	Histidine	62-71	estrogen receptor 1 (alpha)	Mus musculus	104-106
20586183-11	2010	The results indicated that the fusion of GAPDH with the N-terminally His-tagged form gave rise to the accumulation of an expected 43 kDa polypeptide.	Histidine	69-72	glyceraldehyde-3-phosphate dehydrogenase	Ailuropoda melanoleuca	41-46
17916624-4	2007	The CO adduct of Ngb displays two CO absorption bands in the IR spectrum, referred to as N(3) (distal histidine in the pocket) and N(0) (distal histidine swung out of the pocket), which have absorption spectra that are almost identical with the Mb mutants L29F and H64V, respectively.	Histidine	102-111	neuroglobin	Homo sapiens	17-20
17916624-4	2007	The CO adduct of Ngb displays two CO absorption bands in the IR spectrum, referred to as N(3) (distal histidine in the pocket) and N(0) (distal histidine swung out of the pocket), which have absorption spectra that are almost identical with the Mb mutants L29F and H64V, respectively.	Histidine	144-153	neuroglobin	Homo sapiens	17-20
20133602-6	2010	These findings define a consensus motif (which we have called a phenylalanine and histidine [F&amp;H] motif) for OCRL binding and are consistent with a scenario in which Lowe syndrome and Dent disease result from perturbations at multiple sites within the endocytic pathway.	Histidine	82-91	OCRL inositol polyphosphate-5-phosphatase	Homo sapiens	113-117
17706472-2	2007	An amino-terminal histidine fusion tag was added to hSlo, the human BK channel, and expressed in Sf9 insect cells.	Histidine	18-27	potassium calcium-activated channel subfamily M alpha 1	Homo sapiens	52-56
19933215-8	2010	In contrast to the reduced binding properties of the nonsense mutations, the only missense mutation (H363N) found in AMRF leads to increased binding of beta-GC to LIMP-2, indicating that this highly conserved histidine modifies the affinity of LIMP-2 to its ligand.	Histidine	209-218	glucosylceramidase beta	Homo sapiens	152-159
18035827-9	2007	A structural model of FALDH has been constructed, and catalytically important residues have been proposed to be involved in alcohol and aldehyde oxidation: Gln-120, Glu-207, Cys-241, Phe-333, Tyr-410 and His-411.	Histidine	204-207	aldehyde dehydrogenase 3 family member A2	Homo sapiens	22-27
17707404-7	2007	The presence of an N-terminal His-tag on PrxIII markedly enhances dodecamer stability, particularly apparent in its oxidised state.	Histidine	30-33	peroxiredoxin 3	Homo sapiens	41-47
19933215-8	2010	In contrast to the reduced binding properties of the nonsense mutations, the only missense mutation (H363N) found in AMRF leads to increased binding of beta-GC to LIMP-2, indicating that this highly conserved histidine modifies the affinity of LIMP-2 to its ligand.	Histidine	209-218	scavenger receptor class B member 2	Homo sapiens	163-169
19953505-0	2010	pH-dependent stability of neuroserpin is mediated by histidines 119 and 138; implications for the control of beta-sheet A and polymerization.	Histidine	53-63	serpin family I member 1	Homo sapiens	26-37
20641296-2	2004	Both GRP and BN share an amidated C-terminus sequence homology of seven amino acids, -Trp-Ala-Val-Gly-His-Leu-Met-NH2.	Histidine	102-105	gastrin releasing peptide	Homo sapiens	5-8
20058234-3	2010	The small thiol-group-specific reagent N-ethylmaleimide (NEM) was used to modify the cysteine residues in GalP(His)(6) both alone and in the presence of D-glucose, a known substrate.	Histidine	111-114	galanin like peptide	Homo sapiens	106-110
17713929-1	2007	To probe the mechanism of the alkaline conformational transition and its effect on the dynamics of gated electron transfer (ET) reactions, a Lys 79 --&gt; His (K79H) variant of iso-1-cytochrome c has been prepared.	Histidine	155-158	eukaryotic translation initiation factor 1	Homo sapiens	177-182
17691838-1	2007	We investigate the probable proton-transfer pathways from the surface of human carbonic anhydrase II into the active site cavity through His-64 that has been widely implicated as a key residue along the proton-transfer path.	Histidine	137-140	carbonic anhydrase 2	Homo sapiens	79-100
19566844-16	2010	These results suggest that L-histidine decreases blood pressure by attenuating sympathetic output via the central histamine H3 receptor in SHR.	Histidine	27-38	histamine receptor H3	Rattus norvegicus	114-135
20946858-0	2010	Reversible histidine phosphorylation in mammalian cells: a teeter-totter formed by nucleoside diphosphate kinase and protein histidine phosphatase 1.	Histidine	11-20	cytidine/uridine monophosphate kinase 2	Homo sapiens	83-112
17785185-3	2007	N-cadherin antagonistic peptide containing the His-Ala-Val motif (HAV-N) transiently disrupted hippocampal N-cadherin dimerization and impaired the formation of long-term contextual fear memory while sparing short-term memory, retrieval, and extinction.	Histidine	47-50	cadherin 2	Homo sapiens	0-10
17785185-3	2007	N-cadherin antagonistic peptide containing the His-Ala-Val motif (HAV-N) transiently disrupted hippocampal N-cadherin dimerization and impaired the formation of long-term contextual fear memory while sparing short-term memory, retrieval, and extinction.	Histidine	47-50	cadherin 2	Homo sapiens	107-117
20946858-4	2010	Herein, we describe the analysis of the phosphorylation and dephosphorylation of histidine residues by NDPK and PHPT-1.	Histidine	81-90	cytidine/uridine monophosphate kinase 2	Homo sapiens	103-107
19801377-5	2010	Palmitoyl acyltransferases DHHC5, DHHC6, and DHHC8 appear to be S-acylated on three cysteine residues within a novel CCX(7-13)C(S/T) motif downstream of a conserved Asp-His-His-Cys cysteine-rich domain, which may be a potential mechanism for regulating acyltransferase specificity and/or activity.	Histidine	169-172	zinc finger DHHC-type palmitoyltransferase 8	Homo sapiens	45-50
17896967-3	2007	Here we show that 20-200 nM of both N-terminally histidine-tagged recombinant Tat(1-72) and Tat(1-86) stimulated reverse transcription by HIV-1 reverse transcriptase (RT) in vitro by 2-3 fold.	Histidine	49-58	Tat	Human immunodeficiency virus 1	78-81
20061554-4	2010	The interactions between DDB1 and COP1, SPA1, and SPA3 were disrupted by mutations in the WDXR motifs of MBP-COP1, His-SPA1, and His-SPA3.	Histidine	115-118	SPA1-related 3	Arabidopsis thaliana	50-54
20061554-4	2010	The interactions between DDB1 and COP1, SPA1, and SPA3 were disrupted by mutations in the WDXR motifs of MBP-COP1, His-SPA1, and His-SPA3.	Histidine	129-132	SPA1-related 3	Arabidopsis thaliana	50-54
17573342-1	2007	A mutagenic analysis of the amino acid residues His-104 and Cys-166, which are involved in the bi-covalent attachment of FAD to berberine bridge enzyme, was performed.	Histidine	48-51	FA complementation group D2	Homo sapiens	121-124
20061554-4	2010	The interactions between DDB1 and COP1, SPA1, and SPA3 were disrupted by mutations in the WDXR motifs of MBP-COP1, His-SPA1, and His-SPA3.	Histidine	129-132	SPA1-related 3	Arabidopsis thaliana	133-137
17573342-7	2007	Removal of the cysteine linkage to FAD in the C166A mutein leads to a redox potential of +53 mV, which is in the expected range for flavoproteins with a single covalent attachment of FAD to a His residue via its 8-alpha position.	Histidine	192-195	FA complementation group D2	Homo sapiens	35-38
17573342-7	2007	Removal of the cysteine linkage to FAD in the C166A mutein leads to a redox potential of +53 mV, which is in the expected range for flavoproteins with a single covalent attachment of FAD to a His residue via its 8-alpha position.	Histidine	192-195	FA complementation group D2	Homo sapiens	183-186
19682287-8	2009	However, the FAD4 protein contains two histidine motifs resembling those of metalloproteins such as fatty acid desaturases.	Histidine	39-48	fatty acid desaturase A	Arabidopsis thaliana	13-17
17560742-8	2007	The distal ligand-binding histidine at E7, the proximal heme-binding histidine at F8, and the phenylalanine residue at CD1 were conserved in Mb and Cygb.	Histidine	26-35	cytoglobin S homeolog	Xenopus laevis	148-152
17560742-8	2007	The distal ligand-binding histidine at E7, the proximal heme-binding histidine at F8, and the phenylalanine residue at CD1 were conserved in Mb and Cygb.	Histidine	69-78	cytoglobin S homeolog	Xenopus laevis	148-152
19101821-11	2009	The results indicated that the RPS25 gene can be really expressed in E. coli and the RPS25 protein fusioned with the N-terminally his-tagged form gave rise to the accumulation of an expected 17.4 kDa polypeptide.	Histidine	130-133	40S ribosomal protein S25	Ailuropoda melanoleuca	31-36
17659281-2	2007	The structure of OTR revealed that the active site contains an unusual lysine-ligated heme, despite the presence of a CXXCH motif in the sequence that would predict histidine ligation.	Histidine	165-174	tetrathionate reductase family octaheme c-type cytochrome	Shewanella oneidensis MR-1	17-20
19101821-11	2009	The results indicated that the RPS25 gene can be really expressed in E. coli and the RPS25 protein fusioned with the N-terminally his-tagged form gave rise to the accumulation of an expected 17.4 kDa polypeptide.	Histidine	130-133	40S ribosomal protein S25	Ailuropoda melanoleuca	85-90
19706593-2	2009	AHSP forms a specific complex with alphaHb and suppresses the heme-catalyzed evolution of reactive oxygen species by converting alphaHb to a conformation in which the heme is coordinated at both axial positions by histidine side chains (bis-histidyl coordination).	Histidine	214-223	alpha hemoglobin stabilizing protein	Homo sapiens	0-4
17602574-2	2007	The active site coordination of CDO comprises a mononuclear iron ligated by the Nepsilon atoms of three protein-derived histidines, thus representing a new variant on the 2-histidine-1-carboxylate (2H1C) facial triad motif.	Histidine	120-130	cysteine dioxygenase 1, cytosolic	Mus musculus	32-35
22358956-3	1991	Preliminary sequence analysis of the zinc finger motifs in these cDNAs indicate that they belong to a subclass of the Cys-Cys/His-His motif, showing the highest homology to the Wilm"s tumor and EGR1, EGR2 cDNAs.	Histidine	126-129	early growth response 1	Homo sapiens	194-198
22358956-3	1991	Preliminary sequence analysis of the zinc finger motifs in these cDNAs indicate that they belong to a subclass of the Cys-Cys/His-His motif, showing the highest homology to the Wilm"s tumor and EGR1, EGR2 cDNAs.	Histidine	126-129	early growth response 2	Homo sapiens	200-204
22358956-3	1991	Preliminary sequence analysis of the zinc finger motifs in these cDNAs indicate that they belong to a subclass of the Cys-Cys/His-His motif, showing the highest homology to the Wilm"s tumor and EGR1, EGR2 cDNAs.	Histidine	130-133	early growth response 1	Homo sapiens	194-198
22358956-3	1991	Preliminary sequence analysis of the zinc finger motifs in these cDNAs indicate that they belong to a subclass of the Cys-Cys/His-His motif, showing the highest homology to the Wilm"s tumor and EGR1, EGR2 cDNAs.	Histidine	130-133	early growth response 2	Homo sapiens	200-204
17306880-1	2007	PURPOSE: To determine the association between complement factor H (CFH) polymorphism T1277C (tyrosine-402 --&gt; histidine-402) and phenotypic variations of age-related macular degeneration (AMD).	Histidine	113-122	complement factor H	Homo sapiens	46-65
19764800-8	2009	Protein-electrode orientation and efficient intraheme ET enable the His,OH(-)-ligated heme A of the immobilized Met64Ala variant to carry out the reductive electrocatalysis of molecular oxygen.	Histidine	68-71	hemE	Pseudoalteromonas haloplanktis TAC125	49-53
17306880-1	2007	PURPOSE: To determine the association between complement factor H (CFH) polymorphism T1277C (tyrosine-402 --&gt; histidine-402) and phenotypic variations of age-related macular degeneration (AMD).	Histidine	113-122	complement factor H	Homo sapiens	67-70
17306880-12	2007	CONCLUSIONS: Complement factor H polymorphism T1277C (tyrosine-402 --&gt; histidine-402) is strongly associated with both dry and wet AMD and points to a possible role for inflammation in the pathogenesis of AMD.	Histidine	74-83	complement factor H	Homo sapiens	13-32
17372332-2	2007	Recently, we characterized a mutant, G420H, which replaced glycine 420 in the extracellular domain of SR-BI with a histidine residue and had a profound effect on SR-BI function.	Histidine	115-124	scavenger receptor class B member 1	Homo sapiens	102-107
1825621-11	1991	These results suggest that the effect of histidine on ER and PgR levels is probably specific for tumour tissue and is not due to a direct activity.	Histidine	41-50	progesterone receptor	Rattus norvegicus	61-64
1367123-3	1991	Preliminary sequence analysis of the zinc finger motifs in these cDNAs indicate that they belong to a subclass of the Cys-Cys/His-His motif, showing the highest homology to the Wilm"s tumor and EGR1, EGR2 cDNAs.	Histidine	126-129	early growth response 1	Homo sapiens	194-198
1367123-3	1991	Preliminary sequence analysis of the zinc finger motifs in these cDNAs indicate that they belong to a subclass of the Cys-Cys/His-His motif, showing the highest homology to the Wilm"s tumor and EGR1, EGR2 cDNAs.	Histidine	126-129	early growth response 2	Homo sapiens	200-204
1367123-3	1991	Preliminary sequence analysis of the zinc finger motifs in these cDNAs indicate that they belong to a subclass of the Cys-Cys/His-His motif, showing the highest homology to the Wilm"s tumor and EGR1, EGR2 cDNAs.	Histidine	130-133	early growth response 1	Homo sapiens	194-198
1367123-3	1991	Preliminary sequence analysis of the zinc finger motifs in these cDNAs indicate that they belong to a subclass of the Cys-Cys/His-His motif, showing the highest homology to the Wilm"s tumor and EGR1, EGR2 cDNAs.	Histidine	130-133	early growth response 2	Homo sapiens	200-204
1671225-2	1991	We report here the sequence of different forms of the bovine PrP gene which contain either five or six copies of a short, G-C-rich element which encodes the octapeptide Pro-His-Gly-Gly-Gly-Trp-Gly-Gln or its longer variants Pro-Gln/His-Gly-Gly-Gly-Gly-Trp-Gly-Gln.	Histidine	173-176	PRP@	Bos taurus	61-64
2241171-6	1990	In addition, the data of FAB-MS and 1H NMR suggested that the unknown residues (modified histidine) within AGT-1 and AGT-2 should have the 2-imidazolone structure.	Histidine	89-98	FA complementation group B	Homo sapiens	25-28
2241171-6	1990	In addition, the data of FAB-MS and 1H NMR suggested that the unknown residues (modified histidine) within AGT-1 and AGT-2 should have the 2-imidazolone structure.	Histidine	89-98	solute carrier family 7 member 13	Homo sapiens	107-112
2172006-3	1990	Both a conservative change to phenylalanine and a semi-conservative change to histidine at position 37 yield proteins with receptor affinity similar to wild-type hEGF.	Histidine	78-87	epidermal growth factor	Homo sapiens	162-166
2217185-5	1990	Two conserved histidines can be identified at positions 425 and 440 in the cholinesterase family; glutamine replacement at position 440 eliminates activity whereas the mutation at 425 reduces activity only slightly.	Histidine	14-24	butyrylcholinesterase	Homo sapiens	75-89
2395880-0	1990	Substitution of a single amino acid (aspartic acid for histidine) converts the functional activity of human complement C4B to C4A.	Histidine	55-64	complement C4A (Rodgers blood group)	Homo sapiens	126-129
2198282-10	1990	We found that functional hIL-1 alpha had an absolute requirement for a basic residue (Arg, Lys, or His) at either position 15 or 16, and that Leu was preferred at position 40.	Histidine	99-102	interleukin 1 alpha	Homo sapiens	25-36
1976573-3	1990	The two clones are very similar differing by only 1 bp in their coding regions, giving rise to a Tyr/His difference in the gene product, and suggesting that the two clones correspond to A and B allelic variants of BLG.	Histidine	101-104	beta-lactoglobulin-1/B	Ovis aries	214-217
1973165-3	1990	These results indicate that the amino acid sequence Arg-Glu-His at positions 246-248 of S-II is important for its stimulatory activity.	Histidine	60-63	transcription elongation factor A1	Homo sapiens	88-92
1972730-4	1990	CD2 M1 (271-272), CD2 M2 (278-279), and CD2 M4 (264-265) mutants replaced the positively charged adjacent aa histidine and arginine (HR) in the wild-type CD2 sequence with aspartic and glutamic acid (DE) at positions 271-272, 278-279, and 264-265, respectively.	Histidine	109-118	CD2 molecule	Homo sapiens	0-3
2158989-9	1990	Two pairs of resonances are found to have similar relaxation properties and/or dipolar as similarly shifted resonances that arise from a distal His and Arg in horseradish peroxidase (as also found in LPO-CN), and suggest that MPO also possesses these catalytically functional residues in the distal heme pocket.	Histidine	144-147	lactoperoxidase	Bos taurus	200-203
2158989-9	1990	Two pairs of resonances are found to have similar relaxation properties and/or dipolar as similarly shifted resonances that arise from a distal His and Arg in horseradish peroxidase (as also found in LPO-CN), and suggest that MPO also possesses these catalytically functional residues in the distal heme pocket.	Histidine	144-147	myeloperoxidase	Bos taurus	226-229
2179417-8	1990	The mutation at codon 61 of the H-ras gene is consistent with a replacement of glutamine by histidine.	Histidine	92-101	HRas proto-oncogene, GTPase	Homo sapiens	32-37
33973677-7	2021	In silico prediction revealed that HLA-DRB1 alleles with histidine at amino acid position 13 (His13) had significantly weaker binding affinity to an alpha-synuclein epitope than other alleles (P = 9.6 x 10-4 ).	Histidine	57-66	synuclein alpha	Homo sapiens	149-164
34836686-2	2022	Here we applied a His-RARalpha pull-down assay combined with high-resolution mass spectrometry to identify chemicals with RARalpha activity in house dust.	Histidine	18-21	retinoic acid receptor alpha	Homo sapiens	22-30
34836686-2	2022	Here we applied a His-RARalpha pull-down assay combined with high-resolution mass spectrometry to identify chemicals with RARalpha activity in house dust.	Histidine	18-21	retinoic acid receptor alpha	Homo sapiens	122-130
34958513-0	2022	Selective immobilization of his-tagged phosphomannose isomerase on Ni chelated nanoparticles with good reusability and activity.	Histidine	28-31	mannose phosphate isomerase	Homo sapiens	39-63
34958513-2	2022	Phosphomannose isomerase (PMI) with His-tag was successfully immobilized on Ni 2+ charged pyridine-derived particles.	Histidine	36-39	mannose phosphate isomerase	Homo sapiens	0-24
34958513-2	2022	Phosphomannose isomerase (PMI) with His-tag was successfully immobilized on Ni 2+ charged pyridine-derived particles.	Histidine	36-39	mannose phosphate isomerase	Homo sapiens	26-29
34739847-8	2021	Using different PCSK9 constructs, we show that PCSK9 interacts with DACT2 through its Cys-His-rich domain (CHRD) domain.	Histidine	90-93	proprotein convertase subtilisin/kexin type 9	Homo sapiens	47-52
34383999-1	2021	HLA-B*46:64 has one nucleotide change from HLA-B*46:01:01:01 where Histidine (113) is changed to Arginine.	Histidine	67-76	major histocompatibility complex, class I, B	Homo sapiens	43-48
34958277-5	2021	In this study, we aimed to identify the epitope of C20Mab-60 for CD20 using the novel histidine tag (His-tag) insertion for epitope mapping (HisMAP) method.	Histidine	86-95	membrane-spanning 4-domains, subfamily A, member 1	Mus musculus	65-69
34958277-5	2021	In this study, we aimed to identify the epitope of C20Mab-60 for CD20 using the novel histidine tag (His-tag) insertion for epitope mapping (HisMAP) method.	Histidine	101-104	membrane-spanning 4-domains, subfamily A, member 1	Mus musculus	65-69
34735109-0	2021	Theoretical Insights into Mutation and Histidine Tautomerism Effects on Tau Proteins.	Histidine	39-48	microtubule associated protein tau	Homo sapiens	72-75
34735109-2	2021	Mutation and histidine tautomeric effects have been considered the two most important inherent factors for tau protein misfolding.	Histidine	13-22	microtubule associated protein tau	Homo sapiens	107-110
34735109-3	2021	In current research, replica-exchange molecular dynamics (REMD) were performed to characterize the structural properties of the key fragment R3 of tau protein under the collective effects of P332L mutation and histidine tautomerism.	Histidine	210-219	microtubule associated protein tau	Homo sapiens	147-150
34735109-7	2021	The current study will contribute to revealing the collective effects of P332L and histidine tautomerism on the misfolding of tau proteins.	Histidine	83-92	microtubule associated protein tau	Homo sapiens	126-129
34425475-1	2021	Reactions of the anticancer active dirhodium tetraacetate (1), Rh2(AcO)4 (AcO- = CH3COO-), with the amino acid histidine (HHis) and human serum albumin (HSA) were monitored over time and different metal: ligand ratios using UV-vis spectroscopy and/or electro-spray ionization mass spectrometry.	Histidine	111-120	Rh associated glycoprotein	Homo sapiens	63-72
34606713-4	2021	We use histidine-heme loop formation methods, employing eight single histidine variants, to probe for denatured state conformational bias of a UBA(1) domain fused to the N-terminus of iso-1-cytochrome c (iso-1-Cytc).	Histidine	7-16	ubiquitin like modifier activating enzyme 1	Homo sapiens	143-149
34361714-6	2021	In addition, hydrogen bonding occurred between hypericin and alpha-glucosidase amino acid residues Lys-156, Ser-157, Gly-160, Ser-240, His-280, Asp-242, and Asp-307.	Histidine	135-138	sucrase-isomaltase	Homo sapiens	61-78
34299600-9	2021	The method was validated (r2 > 0.999, %RSD < 2, LOD: 10 ng mL-1 for histidine and leucine, 2 ng mL-1 for alanine and valine, and 4 ng mL-1 for Isoleucine) according to the International Conference on Harmonization guidelines.	Histidine	68-77	L1 cell adhesion molecule	Mus musculus	59-63
35557955-1	2022	Human NEET proteins, such as NAF-1 and mitoNEET, are homodimeric, redox iron-sulfur proteins characterized by triple cysteine and one histidine-coordinated (2Fe-2S) cluster.	Histidine	134-143	nuclear assembly factor 1 ribonucleoprotein	Homo sapiens	29-34
35557955-1	2022	Human NEET proteins, such as NAF-1 and mitoNEET, are homodimeric, redox iron-sulfur proteins characterized by triple cysteine and one histidine-coordinated (2Fe-2S) cluster.	Histidine	134-143	CDGSH iron sulfur domain 1	Homo sapiens	39-47
35498747-11	2022	Moreover, distinct changes in liver metabolic profile after ACD treatment were observed, 17 endogenous liver metabolites mainly associated with the metabolism of arachidonic acid, histidine, tyrosine, and tryptophan were reversed by ACD.	Histidine	180-189	adrenocortical dysplasia homolog	Gallus gallus	60-63
35498747-11	2022	Moreover, distinct changes in liver metabolic profile after ACD treatment were observed, 17 endogenous liver metabolites mainly associated with the metabolism of arachidonic acid, histidine, tyrosine, and tryptophan were reversed by ACD.	Histidine	180-189	adrenocortical dysplasia homolog	Gallus gallus	233-236
35339000-4	2022	The activated caspase-3 and changes of ATPase activity in UMH-treated meat accelerated the postmortem ageing, and L-histidine might competitively inhibit the actin-myosin binding by the imidazole group.	Histidine	114-125	myosin heavy chain 14	Homo sapiens	164-170
35284834-3	2022	We obtain highly pure N-terminal His-tagged HLA-A2 alpha chain and beta2-microglobulin (beta2m) to fold a monomer with a photocleavable peptide, which can exchange with an HLA-A2 presented peptide derived from influenza A virus.	Histidine	33-36	alpha-2-macroglobulin	Homo sapiens	88-94
35090891-9	2022	We show Histidine clusters, on other hand, bind Cu(II) and are crucial for hCTR1 functioning at limiting copper.	Histidine	8-17	solute carrier family 31 member 1	Homo sapiens	75-80
35090891-10	2022	Finally, we show that two N-terminal His-Met-Asp clusters exhibit functional complementarity, as the second cluster is sufficient to preserve copper-induced CTR1 endocytosis upon complete deletion of the first cluster.	Histidine	37-40	solute carrier family 31 member 1	Homo sapiens	157-161
35267786-5	2022	Results showed a high quality of the extracted-elastin with the presence of a high amount of proline (6.55 +- 0.40%) and glycine (9.65 +- 0.44%), low amount of hydroxyproline (0.80 +- 0.32%), methionine (2.04 +- 0.05%), and histidine (1.81 +- 0.05%) together with calculated 0.56 isoleucine/leucine ratio.	Histidine	224-233	elastin	Bos taurus	47-54
35216507-5	2022	The inhibitors successfully engaged the catalytic dyad histidine residue (H41) of 3CLPro as designed, and they exhibited nanomolar inhibitory capacity as well as mitigated the viral loads of SARS-CoV-2 in cellular assays.	Histidine	55-64	CDV3 homolog	Homo sapiens	74-77
35129437-5	2022	A glutamine-rich low complexity domain (QLC) in the SNF5 subunit of this complex, and histidines within this sequence, were required for efficient transcriptional reprogramming.	Histidine	86-96	Snf5p	Saccharomyces cerevisiae S288C	52-56
35129437-7	2022	Simulations showed that protonation of histidines within the SNF5 QLC lead to conformational expansion, providing a potential biophysical mechanism for regulation of these interactions.	Histidine	39-49	Snf5p	Saccharomyces cerevisiae S288C	61-65
16882456-1	2007	In a previous work, we identified a Cys(2)/His(2)-type zinc-finger transcription repressor, (ZFT1), that functions in a spermine-mediated signal transduction pathway in tobacco plants.	Histidine	43-46	zinc finger protein ZAT10-like	Nicotiana tabacum	93-97
17468887-4	2007	As described in other SCD proteins, the predicted amino acid sequence of bovine SCD5 includes four transmembrane domains and three conserved histidine motifs.	Histidine	141-150	stearoyl-CoA desaturase 5	Bos taurus	80-84
17460754-5	2007	By assessing cell viability with the MTT reduction assay, we found that salsolinol exhibited a selective toxicity toward OCT2-expressing cells that was prevented by cyclo(his-pro).	Histidine	171-174	POU class 2 homeobox 2	Homo sapiens	121-125
17460754-6	2007	A frequent genetic variant of OCT2 with the amino acid substitution R400C reduced the transport efficiency for the cytoprotective cyclo(his-pro) and thereby increased the susceptibility to salsolinol-induced cell death.	Histidine	136-139	POU class 2 homeobox 2	Homo sapiens	30-34
17460754-7	2007	CONCLUSIONS/SIGNIFICANCE: Our findings indicate that the OCT2-regulated interplay between cyclo(his-pro) and salsolinol is crucial for nigral cell integrity and that a shift in transport efficiency may impact the risk of Parkinson"s disease.	Histidine	96-99	POU class 2 homeobox 2	Homo sapiens	57-61
17293598-2	2007	When histidine instead of tyrosine is present at position 384 in the seventh complement control protein (CCP) domain of FH, the risk for age-related macular degeneration is increased.	Histidine	5-14	complement factor H	Homo sapiens	120-122
17207559-4	2007	Histidine(4), tyrosine(5), tryptophan(6), histidine(7)-TIP39 binds the PTH2 receptor with high affinity, has over 30-fold selectivity for the rat PTH2 receptor over the rat PTH1 receptor and displays no detectable agonist activity.	Histidine	0-9	parathyroid hormone 2 receptor	Rattus norvegicus	71-84
17207559-4	2007	Histidine(4), tyrosine(5), tryptophan(6), histidine(7)-TIP39 binds the PTH2 receptor with high affinity, has over 30-fold selectivity for the rat PTH2 receptor over the rat PTH1 receptor and displays no detectable agonist activity.	Histidine	0-9	parathyroid hormone 2 receptor	Rattus norvegicus	146-159
17207559-4	2007	Histidine(4), tyrosine(5), tryptophan(6), histidine(7)-TIP39 binds the PTH2 receptor with high affinity, has over 30-fold selectivity for the rat PTH2 receptor over the rat PTH1 receptor and displays no detectable agonist activity.	Histidine	0-9	parathyroid hormone 1 receptor	Rattus norvegicus	173-186
17207559-4	2007	Histidine(4), tyrosine(5), tryptophan(6), histidine(7)-TIP39 binds the PTH2 receptor with high affinity, has over 30-fold selectivity for the rat PTH2 receptor over the rat PTH1 receptor and displays no detectable agonist activity.	Histidine	42-51	parathyroid hormone 2 receptor	Rattus norvegicus	71-84
17207559-4	2007	Histidine(4), tyrosine(5), tryptophan(6), histidine(7)-TIP39 binds the PTH2 receptor with high affinity, has over 30-fold selectivity for the rat PTH2 receptor over the rat PTH1 receptor and displays no detectable agonist activity.	Histidine	42-51	parathyroid hormone 2 receptor	Rattus norvegicus	146-159
17207559-4	2007	Histidine(4), tyrosine(5), tryptophan(6), histidine(7)-TIP39 binds the PTH2 receptor with high affinity, has over 30-fold selectivity for the rat PTH2 receptor over the rat PTH1 receptor and displays no detectable agonist activity.	Histidine	42-51	parathyroid hormone 1 receptor	Rattus norvegicus	173-186
17319695-1	2007	Histidine at position 64 (His64) in human carbonic anhydrase II (HCA II) is believed to be the proton acceptor in the hydration direction and the proton donor in the dehydration direction for the rate-limiting proton transfer (PT) event.	Histidine	0-9	carbonic anhydrase 2	Homo sapiens	42-63
17234634-4	2007	The purified native or N-terminal His-tagged recombinant rat RCL protein expressed in Escherichia coli exhibits the same enzyme activity, deoxynucleoside 5"-monophosphate N-glycosidase, never before described.	Histidine	34-37	2'-deoxynucleoside 5'-phosphate N-hydrolase 1	Rattus norvegicus	61-64
17287358-5	2007	Detection of a pHis containing peptide from the yeast protein, Cdc10, suggests an unexpected role for histidine phosphorylation in septin biology.	Histidine	102-111	septin CDC10	Saccharomyces cerevisiae S288C	63-68
17217471-6	2007	Histidine-tagged Arabidopsis PMM (AtPMM) purified from Escherichia coli converted mannose-1-phosphate into mannose-6-phosphate and glucose-1-phosphate into glucose-6-phosphate, with the former reaction being more efficient than the latter one.	Histidine	0-9	phosphomannomutase	Arabidopsis thaliana	29-32
17244493-0	2007	Protective effects of histidine dipeptides on the modification of neurofilament-L by the cytochrome c/hydrogen peroxide system.	Histidine	22-31	neurofilament light chain	Homo sapiens	66-81
17244493-4	2007	In the present study, we investigated whether histidine dipeptides, carnosine, homocarnosine, or anserine protect NF-L against oxidative modification during reaction between cytochrome c and H(2)O(2).	Histidine	46-55	neurofilament light chain	Homo sapiens	114-118
18401441-3	2007	Specifically, we have expressed and purified the catalytic kinase domain of PDK1 with an N-terminal histidine tag [His(6)-PDK1(DeltaPH)].	Histidine	100-109	pyruvate dehydrogenase kinase 1	Homo sapiens	76-80
18401441-3	2007	Specifically, we have expressed and purified the catalytic kinase domain of PDK1 with an N-terminal histidine tag [His(6)-PDK1(DeltaPH)].	Histidine	100-109	pyruvate dehydrogenase kinase 1	Homo sapiens	122-126
18401441-3	2007	Specifically, we have expressed and purified the catalytic kinase domain of PDK1 with an N-terminal histidine tag [His(6)-PDK1(DeltaPH)].	Histidine	115-118	pyruvate dehydrogenase kinase 1	Homo sapiens	76-80
18401441-3	2007	Specifically, we have expressed and purified the catalytic kinase domain of PDK1 with an N-terminal histidine tag [His(6)-PDK1(DeltaPH)].	Histidine	115-118	pyruvate dehydrogenase kinase 1	Homo sapiens	122-126
18401441-5	2007	The supramolecular association of the BODIPY-ATP dyad with the His(6)-PDK1(DeltaPH)-QD assembly encourages the transfer of energy from the QDs to the BODIPY dyes upon excitation.	Histidine	63-66	pyruvate dehydrogenase kinase 1	Homo sapiens	70-74
17176064-1	2006	An essential histidine ligand to the electron transfer copper (CuH) of peptidylglycine alpha-hydroxylating monooxygenase (PHMcc) was mutated to an alanine and found to retain copper binding and hydroxylase activity [Jaron, S., et al.	Histidine	13-22	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	71-120
17079265-8	2006	HAP2 is predicted to encode a protein with an N-terminal secretion signal, a single transmembrane domain and a C-terminal histidine-rich domain.	Histidine	122-131	hapless 2	Arabidopsis thaliana	0-4
16985102-12	2006	The increase in catalytic efficiency observed for Pro360 in human FMO3 was also observed when the His of FMO1 was replaced by Pro at loci 360.	Histidine	98-101	flavin containing dimethylaniline monoxygenase 3	Homo sapiens	66-70
16981206-3	2006	Three L-arginine-metal coordination interactions are found in metalloenzyme structures deposited in the Protein Data Bank: biotin synthase from E. coli, His-67 --&gt; Arg human carbonic anhydrase I, and inactivated B. caldovelox arginase complexed with L-arginine.	Histidine	153-156	carbonic anhydrase 1	Homo sapiens	177-197
16828555-7	2006	Accordingly, site-directed mutagenesis of Gln-148 of 15-PGDH to alanine, glutamic acid, histidine, and asparagine (Q148A, Q148E, Q148H, and Q148N) was carried out.	Histidine	88-97	carbonyl reductase 1	Homo sapiens	53-60
16844077-1	2006	The proteins from the ZIP and the CDF families of zinc transporters contain a histidine-rich sequence in a loop domain located between transmembrane domains III and IV for the ZIP family and transmembrane domains IV and V for the CDF family.	Histidine	78-87	death associated protein kinase 3	Homo sapiens	22-25
16844077-1	2006	The proteins from the ZIP and the CDF families of zinc transporters contain a histidine-rich sequence in a loop domain located between transmembrane domains III and IV for the ZIP family and transmembrane domains IV and V for the CDF family.	Histidine	78-87	death associated protein kinase 3	Homo sapiens	176-179
16972175-21	2006	Analysis of the FH gene revealed the maternally derived c.1029_1031delAGT mutation, resulting in Val deletion and substitution of Gln by His, and paternally derived c.976C &gt; T mutation, resulting in substitution of Pro by Ser.	Histidine	137-140	fumarate hydratase	Homo sapiens	16-18
16967187-8	2006	All these findings suggested that the fused expressed His-DR inhibited the activity of natural DDR2, and relevant MMP-1 and MMP-2 expression in synoviocytes and NIH3T3 cells provoked by collagen II.	Histidine	54-57	matrix metallopeptidase 2	Mus musculus	124-129
16934294-0	2006	Histidine triad-like motif of the rotavirus NSP2 octamer mediates both RTPase and NTPase activities.	Histidine	0-9	inosine triphosphatase	Homo sapiens	82-88
16878944-1	2006	Methods to fine-tune the rate of a fast conformational electron transfer (ET) gate involving a His-heme alkaline conformer of iso-1-cytochrome c (iso-1-Cytc) and to adjust the pH accessibility of a slow ET gate involving a Lys-heme alkaline conformer are described.	Histidine	95-98	eukaryotic translation initiation factor 1	Homo sapiens	146-156
17083198-7	2006	The recombinant plasmid pET28a/mIL-21 with a carboxyl terminal His-tag was subcloned from the pcDNA3.1/mIL-21 and expressed in E. coli.	Histidine	63-66	interleukin 21	Mus musculus	31-37
16817320-0	2006	Histidine 89 is an essential residue for Hsp70 in the phosphate transfer reaction.	Histidine	0-9	heat shock protein family A (Hsp70) member 4	Homo sapiens	41-46
16817320-3	2006	In this study we determined the site of histidine phosphorylation of Hsp70 as an intermediate in the process of phosphate transfer reaction by site-directed mutagenesis.	Histidine	40-49	heat shock protein family A (Hsp70) member 4	Homo sapiens	69-74
16714405-3	2006	A purified N-terminally hexahistidinyl-tagged AtPCS1 truncate containing only the first 221 N-terminal amino acid residues of the enzyme (HIS-AtPCS1_221tr) is competent in the synthesis of PCs from GSH in media containing Cd2+ or the synthesis of S-methyl-PCs from S-methylglutathione in media devoid of heavy metal ions.	Histidine	138-141	Eukaryotic aspartyl protease family protein	Arabidopsis thaliana	46-52
16714405-3	2006	A purified N-terminally hexahistidinyl-tagged AtPCS1 truncate containing only the first 221 N-terminal amino acid residues of the enzyme (HIS-AtPCS1_221tr) is competent in the synthesis of PCs from GSH in media containing Cd2+ or the synthesis of S-methyl-PCs from S-methylglutathione in media devoid of heavy metal ions.	Histidine	138-141	Eukaryotic aspartyl protease family protein	Arabidopsis thaliana	142-148
16332725-4	2006	The ADH2 Arg allele was found to be associated with increased risk, the odds ratios (ORs) being 1.35 (95% confidence interval: 1.00-1.84) and 1.93 (1.06-3.53) for the His/Arg and Arg/Arg genotypes, respectively.	Histidine	167-170	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	4-8
16641296-6	2006	The native structure of the protease reveals strong hydrogen bond interactions between His 30 and Glu 54, in the favorable syn configuration, indicating a role of Glu 54 during proteolysis.	Histidine	87-90	synemin	Homo sapiens	123-126
16762846-4	2006	The phosphorylation of ATF2 was detected to assay the effect of His-TAT-p38 on endogeneious p38 activity after the cells were stimulated by sorbitol.	Histidine	64-67	activating transcription factor 2	Homo sapiens	23-27
16761408-14	2006	The results of SDS-PAGE and Western blot showed the rE4 was expressed mainly to form the inclusion body, and to fuse with his-tag (rE4/His), that was soluble and had a molecular weight as about 34 KDa.	Histidine	122-125	WAP four-disulfide core domain 2	Rattus norvegicus	52-55
16761408-14	2006	The results of SDS-PAGE and Western blot showed the rE4 was expressed mainly to form the inclusion body, and to fuse with his-tag (rE4/His), that was soluble and had a molecular weight as about 34 KDa.	Histidine	122-125	WAP four-disulfide core domain 2	Rattus norvegicus	131-134
16490786-6	2006	A purified histidine-tagged Pte1p showed high activity toward short and medium chain length acyl-CoAs, including butyryl-CoA, decanoyl-CoA and 8-methyl-nonanoyl-CoA.	Histidine	11-20	palmitoyl-CoA hydrolase	Saccharomyces cerevisiae S288C	28-33
16297612-1	2006	An olfactory receptor protein of C. elegans, ODR-10, was expressed in Escherichia coli as a fusion protein, with GST and 6x His-tag.	Histidine	124-127	Serpentine receptor class r-10	Caenorhabditis elegans	45-51
16511838-5	2006	One novel missense variant in exon 4, derived from the nucleotide transition in codon 162 (CGT --> CAT:485G > A) resulting in an arginine-to-histidine (Arg --> His) change, was detected in these subjects.	Histidine	141-150	UDP glycosyltransferase 8	Homo sapiens	91-94
16511838-5	2006	One novel missense variant in exon 4, derived from the nucleotide transition in codon 162 (CGT --> CAT:485G > A) resulting in an arginine-to-histidine (Arg --> His) change, was detected in these subjects.	Histidine	160-163	UDP glycosyltransferase 8	Homo sapiens	91-94
16696901-3	2006	In present study, the extracellular domain of human PD-1 with a carboxyl terminal His-tag (designated as sPD-1) was expressed as inclusion bodies in Escherichia coli.	Histidine	82-85	homeobox D13	Homo sapiens	105-110
16210335-1	2006	In the present study, we examined the role in hematopoiesis of cationic amino acid transporter 1 (CAT1), which transports L-arginine, L-lysine, L-ornithine, and L-histidine.	Histidine	161-172	solute carrier family 7 member 1	Homo sapiens	63-96
16210335-1	2006	In the present study, we examined the role in hematopoiesis of cationic amino acid transporter 1 (CAT1), which transports L-arginine, L-lysine, L-ornithine, and L-histidine.	Histidine	161-172	solute carrier family 7 member 1	Homo sapiens	98-102
16828466-5	2006	Moving in vivo, we demonstrated that subcutaneously administered his(6)CTLA-4.FasL modulates the in vivo response of infused allogeneic splenocytes.	Histidine	65-68	cytotoxic T-lymphocyte-associated protein 4	Mus musculus	71-77
16441489-4	2006	The HLA-DQB1*0627 alleles contain a nucleotide substitution at position 184 (T to C) resulting in an amino acid exchange from tyrosine to histidine.	Histidine	138-147	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	4-12
16363808-3	2005	Two cysteine residues (C45 and C49) in the sequence CXXXCP and a histidine (H135) approximately 90 residues toward the C-terminus are conserved in Sco from bacteria, yeast, and humans.	Histidine	65-74	DELYQ11	Homo sapiens	147-150
16214338-1	2005	Activation of the carbonic anhydrase (CA, EC 4.2.1.1) isoforms hCA I, II, and IV with l-histidine and some of its derivatives has been investigated by kinetic and X-ray crystallographic methods.	Histidine	86-97	carbonic anhydrase 1	Homo sapiens	63-68
16214338-4	2005	The X-ray crystallographic structure of the hCA II-l-His adduct showed the activator to be anchored at the entrance of the active site cavity, participating in an extended network of hydrogen bonds with the amino acid residues His64, Asn67, and Gln92 and, with three water molecules connecting it to the zinc-bound water.	Histidine	53-56	carbonic anhydrase 2	Homo sapiens	44-50
16314460-6	2005	Thus, in U4 atac snRNA we identified His 270 in the spliceosomal U4/U6 snRNP-specific protein 61 K (hPrp31p) cross-linked to U 44; in the U1 snRNP we show that Leu175 of the U1 snRNP-specific 70K protein is cross-linked to U 30 of U1 snRNA.	Histidine	37-40	pre-mRNA processing factor 31	Homo sapiens	100-107
16106378-1	2005	Human carbonic anhydrase II (HCA II) has a histidine at position 64 (His64) that donates a proton to the zinc-bound hydroxide in catalysis of the dehydration of bicarbonate.	Histidine	43-52	carbonic anhydrase 2	Homo sapiens	6-27
16051603-6	2005	Additionally, mutational analysis identifies the histidine binding sites within a region highly conserved between HisZ and the functional HisRS.	Histidine	49-58	histidyl-tRNA synthetase 2, mitochondrial	Homo sapiens	138-143
16441176-6	2005	The polymers have lower critical solution temperatures which occur at sub-ambient temperatures and have proven useful in the affinity precipitation of proteins which are particularly temperature sensitive, e.g. the histidine-tagged protein fragment BRCA1.	Histidine	215-224	BRCA1 DNA repair associated	Homo sapiens	249-254
15993513-2	2005	A series of tetrapeptides, based on Tic-DPhe-Arg-Trp-NH2-a mimic of the putative message sequence "His-Phe-Arg-Trp" and modified at the DPhe position, were prepared and pharmacologically characterized for potency and selectivity.	Histidine	99-102	aryl hydrocarbon receptor nuclear translocator-like	Rattus norvegicus	36-39
16027123-11	2005	Chemical modification of the single histidine residue (His15) located in helix A of WT mGM-CSF with diethyl pyrocarbonate totally abolished binding to immobilized heparin.	Histidine	36-45	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	87-94
16027123-13	2005	These results indicate a major role of histidine residues in the regulation of the binding of GM-CSF to GAGs, supporting the notion that an acidic microenvironment is required for GM-CSF-dependent regulation of target cells.	Histidine	39-48	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	94-100
16027123-13	2005	These results indicate a major role of histidine residues in the regulation of the binding of GM-CSF to GAGs, supporting the notion that an acidic microenvironment is required for GM-CSF-dependent regulation of target cells.	Histidine	39-48	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	180-186
16014379-2	2005	In this study, Hint1/PKCI, a member of the evolutionary conserved family of histidine triad proteins, was characterised as a new interaction partner of Pontin and Reptin.	Histidine	76-85	protein kinase C iota	Homo sapiens	21-25
15876520-4	2005	Both of the siblings were compound heterozygotes with aprataxin gene mutations, 689 insT and G692A, in exon 5 that encodes the histidine triad domain of the aprataxin protein.	Histidine	127-136	aprataxin	Homo sapiens	54-63
15876520-4	2005	Both of the siblings were compound heterozygotes with aprataxin gene mutations, 689 insT and G692A, in exon 5 that encodes the histidine triad domain of the aprataxin protein.	Histidine	127-136	aprataxin	Homo sapiens	157-166
15767264-1	2005	In Arabidopsis thaliana, AUTHENTIC RESPONSE REGULATORS (ARRs) act as downstream components of the His-to-Asp phosphorelay (two-component) signaling pathway that is propagated primarily by the cytokinin receptor kinases, AUTHENTIC HIS-KINASES (AHK2, AHK3 and AHK4/CRE1).	Histidine	98-101	histidine kinase 2	Arabidopsis thaliana	243-247
15572352-2	2005	ATP-dependent uptake of histidine and lysine by isolated vacuolar membrane vesicles was impaired in YMR088c, a vacuolar basic amino acid transporter 1 (VBA1)-deleted strain, whereas uptake of tyrosine or calcium was little affected.	Histidine	24-33	Vba1p	Saccharomyces cerevisiae S288C	152-156
15572352-3	2005	This defect in histidine and lysine uptake was complemented fully by introducing the VBA1 gene and partially by a gene encoding Vba1p fused with green fluorescent protein, which was determined to localize exclusively to the vacuolar membrane.	Histidine	15-24	Vba1p	Saccharomyces cerevisiae S288C	85-89
15572352-3	2005	This defect in histidine and lysine uptake was complemented fully by introducing the VBA1 gene and partially by a gene encoding Vba1p fused with green fluorescent protein, which was determined to localize exclusively to the vacuolar membrane.	Histidine	15-24	Vba1p	Saccharomyces cerevisiae S288C	128-133
15661533-4	2005	OVCA1 appears to be the homolog of yeast DPH2, which participates in the first biosynthetic step of diphthamide, by modification of histidine on translation elongation factor 2 (EF-2).	Histidine	132-141	diphthamide biosynthesis 1	Mus musculus	0-5
15665078-7	2005	Sequence homology analysis indicated that, with one exception, the histidine residues that were previously shown to be important for pH sensing by OGR1, GPR4, and TDAG8 were not conserved in the G2A receptor.	Histidine	67-76	G protein-coupled receptor 68	Mus musculus	147-151
15665078-7	2005	Sequence homology analysis indicated that, with one exception, the histidine residues that were previously shown to be important for pH sensing by OGR1, GPR4, and TDAG8 were not conserved in the G2A receptor.	Histidine	67-76	G-protein coupled receptor 65	Mus musculus	163-168
15501526-9	2004	The selective VPAC(1) receptor antagonist Ac His(1) [D-Phe(2), K(15), R(16), L(27)] VIP (3-7)/GRF (8-27) reduced by 60% the basal activity with an EC(50) value of 3 nM comparable to its IC(50) value for binding.	Histidine	45-48	VIP peptides	Cricetulus griseus	84-87
15476823-2	2004	The site of interaction of the tumor suppressor p53 and the oncoprotein E1A with CBP/p300 has been identified with the third cysteine-histidine-rich (CH3) domain, which incorporates two zinc-binding motifs, ZZ and TAZ2.	Histidine	134-143	CREB binding protein	Mus musculus	81-84
15476823-2	2004	The site of interaction of the tumor suppressor p53 and the oncoprotein E1A with CBP/p300 has been identified with the third cysteine-histidine-rich (CH3) domain, which incorporates two zinc-binding motifs, ZZ and TAZ2.	Histidine	134-143	E1A binding protein p300	Mus musculus	85-89
15450853-5	2004	Vibrio PGI contains motifs for the serine, histidine and aspartic acid active sites of the subtilase family of serine proteases which form a putative catalytic triad consisting of His534 and Ser159 on the 60.8-kDa subunit and Asp53 on the 23.4-kDa subunit.	Histidine	43-52	glucose-6-phosphate isomerase	Oryctolagus cuniculus	7-10
15528859-5	2004	In addition, the feline CD7 protein fused with histidine tag was expressed in 293T cells.	Histidine	47-56	CD7 molecule	Homo sapiens	24-27
15325241-3	2004	The present study provides experimental evidence that the histidine triad (HIT) domain in aprataxin has enzymatic activity that is negatively regulated by the intramolecular interaction of the N-terminal domain.	Histidine	58-67	aprataxin	Homo sapiens	90-99
15226302-2	2004	The wbpA gene that encodes this enzyme was cloned into pET-28a, overexpressed as a histidine-tagged fusion protein, and purified by nickel chelation chromatography.	Histidine	83-92	UDP-N-acetyl-d-glucosamine 6-dehydrogenase	Pseudomonas aeruginosa PAO1	4-8
15358233-5	2004	Furthermore, His-p53 and FLAG-XPG, but not PCNA, stimulated the Tg DNA glycosylase/AP lyase activity of GST-NTH1 or NTH1.	Histidine	13-16	nth like DNA glycosylase 1	Homo sapiens	116-120
19320425-6	2009	Cd(2+) and Msh2-Msh6 interactions involve cysteine sulfhydryl groups, and the high Cd(2+):Msh2-Msh6 ratio implicates other ligands such as histidine, aspartate, glutamate, and the peptide backbone as well.	Histidine	139-148	mutS homolog 6	Homo sapiens	95-99
15236321-5	2004	Both rat spetex-1 and the mouse homologue contained Ser-X (X = His, Arg, or Asn) repeats in the middle portion of the proteins.	Histidine	63-66	spermatogenesis associated 18	Rattus norvegicus	9-17
19422058-5	2009	The molecular function and structural features of SPINK2 were also investigated by employing the recombinant active and mutant inactive SPINK2 proteins to determine its key P2-P2" (Pro(23)-Arg(24)-His(25)-Phe(26)) active site.	Histidine	197-200	serine peptidase inhibitor Kazal type 2	Homo sapiens	50-56
15273299-6	2004	The reaction PQQ--&gt;PQQH- occurs with Glu 171-CO2- and His 144-Im as the base species in MDH and sGDH, respectively.	Histidine	57-60	malate dehydrogenase 2	Homo sapiens	91-94
15196988-5	2004	In CYP2A6, the amino acid residues at position 117 and 372 are valine (Val) and arginine (Arg), respectively; whereas in CYP2A13, they are alanine (Ala) and histidine (His).	Histidine	157-166	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	3-9
15196988-5	2004	In CYP2A6, the amino acid residues at position 117 and 372 are valine (Val) and arginine (Arg), respectively; whereas in CYP2A13, they are alanine (Ala) and histidine (His).	Histidine	157-166	cytochrome P450 family 2 subfamily A member 13	Homo sapiens	121-128
19422058-7	2009	Although His(25) at the P1" and Phe(26) at the P2" residues are also involved in trypsin-SPINK2 interaction, Pro(23) at the P2 site may not be directly participated in interacting with trypsin.	Histidine	9-12	serine peptidase inhibitor Kazal type 2	Homo sapiens	89-95
15196988-5	2004	In CYP2A6, the amino acid residues at position 117 and 372 are valine (Val) and arginine (Arg), respectively; whereas in CYP2A13, they are alanine (Ala) and histidine (His).	Histidine	168-171	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	3-9
15196988-5	2004	In CYP2A6, the amino acid residues at position 117 and 372 are valine (Val) and arginine (Arg), respectively; whereas in CYP2A13, they are alanine (Ala) and histidine (His).	Histidine	168-171	cytochrome P450 family 2 subfamily A member 13	Homo sapiens	121-128
19777055-14	2009	For the first time, to our knowledge, we demonstrate that changing the histidine residue in the conserved CPHGRP motif abolishes endonucleolytic activity of a hPMS2 homologue.	Histidine	71-80	PMS1 homolog 2, mismatch repair system component	Homo sapiens	159-164
15189568-5	2004	swi encodes a predicted 68.5-kDa protein that contains N-terminal histidine-rich and threonine-rich domains, a cysteine-rich C-terminal region and two leucine-rich repeats.	Histidine	66-75	halfway	Drosophila melanogaster	0-3
19553567-2	2009	Homology models constructed on the basis of the experimental structures of Escherichia coli AmtB and Nitrosomonas europaea Rh50 indicated a channel structure for human RhA (RhAG), RhB (RhBG), and RhC (RhCG) glycoproteins in which external and internal vestibules are linked by a pore containing two strictly conserved histidines.	Histidine	318-328	Rh associated glycoprotein	Homo sapiens	168-171
15138608-9	2004	JD2H domain with C2HC2HC2- and C5HC2-type Cys (His) clusters was identified as the region conserved among JMJD2A (1064 aa), JMJD2B (1096 aa), and JMJD2C (1056 aa) proteins.	Histidine	47-50	lysine demethylase 4A	Homo sapiens	106-112
15138608-9	2004	JD2H domain with C2HC2HC2- and C5HC2-type Cys (His) clusters was identified as the region conserved among JMJD2A (1064 aa), JMJD2B (1096 aa), and JMJD2C (1056 aa) proteins.	Histidine	47-50	lysine demethylase 4C	Homo sapiens	146-152
19553567-2	2009	Homology models constructed on the basis of the experimental structures of Escherichia coli AmtB and Nitrosomonas europaea Rh50 indicated a channel structure for human RhA (RhAG), RhB (RhBG), and RhC (RhCG) glycoproteins in which external and internal vestibules are linked by a pore containing two strictly conserved histidines.	Histidine	318-328	Rh associated glycoprotein	Homo sapiens	173-177
19399589-5	2009	Further we find that rising [AMP] promotes pSer (only with GTP) but inhibits histidine phosphorylation (pHis) of NDPK from both donors.	Histidine	77-86	cytidine/uridine monophosphate kinase 2	Homo sapiens	113-117
15073296-6	2004	DevR-DevS was thus established as a typical two-component regulatory system based on His-to-Asp phosphoryl transfer.	Histidine	85-88	two component transcriptional regulator DevR	Mycobacterium tuberculosis H37Rv	0-4
19415463-1	2009	The guest editor (AM) provides his perspective on the most recent advances on nucleoside diphosphate kinase (NDPK, otherwise known as AWD or NM23) showcasing phospho-histidine biochemistry and its impact on diverse pathology when disordered.	Histidine	166-175	cytidine/uridine monophosphate kinase 2	Homo sapiens	78-107
19415463-1	2009	The guest editor (AM) provides his perspective on the most recent advances on nucleoside diphosphate kinase (NDPK, otherwise known as AWD or NM23) showcasing phospho-histidine biochemistry and its impact on diverse pathology when disordered.	Histidine	166-175	cytidine/uridine monophosphate kinase 2	Homo sapiens	109-113
15032831-10	2004	The results are discussed in terms of different binding properties of the heme iron to the protonated or unprotonated histidine ligand in the high-potential and low-potential forms of cytochrome b(559), respectively.	Histidine	118-127	mitochondrially encoded cytochrome b	Homo sapiens	184-196
19706422-3	2009	EPR, Mossbauer, and XAS spectroscopic results presented herein provide direct spectroscopic evidence that hDOHH has an antiferromagnetically coupled diiron center with histidines and carboxylates as likely ligands, as suggested by mutagenesis experiments.	Histidine	168-178	deoxyhypusine hydroxylase	Homo sapiens	106-111
19716620-4	2009	Furthermore, we find that cox1 expression involves U-to-C editing, reconstituting an otherwise invariant, essential histidine involved in copper binding.	Histidine	116-125	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	26-30
15058570-6	2004	It was found that among the examined matrices, the TSK Chelate-5PW sorbent bound histidine-containing peptides the strongest, while Poros matrix was found to have a high degree of non-specific bindings.	Histidine	81-90	tsukushi, small leucine rich proteoglycan	Homo sapiens	51-54
14762120-10	2004	The interaction was also confirmed by a "pull-down" assay in which histidine-tagged ACBP was used to pull down the GABA(A)alpha1.	Histidine	67-76	acyl-CoA-binding protein	Oryctolagus cuniculus	84-88
19501583-5	2009	A point mutation resulting in a leucine-to-histidine change was detected in the thrombospondin domain of the col9alpha1 gene in prp.	Histidine	43-52	collagen, type XXII, alpha 1	Danio rerio	128-131
12905028-9	2004	PHT1 and PHT2 were shown to transport free histidine and certain di- and tripeptides, but it is not yet clear whether they are located on the plasma membrane or represent lysosomal transporters for the proton-dependent export of histidine and dipeptides from lysosomal protein degradation into the cytosol.	Histidine	43-52	solute carrier family 15 member 3	Homo sapiens	9-13
12905028-9	2004	PHT1 and PHT2 were shown to transport free histidine and certain di- and tripeptides, but it is not yet clear whether they are located on the plasma membrane or represent lysosomal transporters for the proton-dependent export of histidine and dipeptides from lysosomal protein degradation into the cytosol.	Histidine	229-238	solute carrier family 15 member 3	Homo sapiens	9-13
19396588-2	2009	In order to bind the enzyme complex consisting of UL5 and UL52 gene functions to the affinity column, the C-terminus of the UL5 gene of HSV-1 strain ANG was fused in-frame with a sequence encoding six histidines, resulting in a His6-tagged DNA helicase (UL5his) when expressed via recombinant baculovirus.	Histidine	201-211	helicase-primase primase subunit	Human alphaherpesvirus 1	58-62
14580238-1	2004	We have introduced a pseudoachondroplasia-associated mutation (His(587)--&gt;Arg) into the C-terminal collagen-binding domain of COMP (cartilage oligomeric matrix protein) and recombinantly expressed the full-length protein as well as truncated fragments in HEK-293 cells.	Histidine	63-66	cartilage oligomeric matrix protein	Homo sapiens	129-133
14580238-1	2004	We have introduced a pseudoachondroplasia-associated mutation (His(587)--&gt;Arg) into the C-terminal collagen-binding domain of COMP (cartilage oligomeric matrix protein) and recombinantly expressed the full-length protein as well as truncated fragments in HEK-293 cells.	Histidine	63-66	cartilage oligomeric matrix protein	Homo sapiens	135-170
14580238-6	2004	Also a COMP His(587)--&gt;Arg fragment encompassing the calcium-binding repeats and the C-terminal collagen-binding domain bound collagens equally well as the corresponding wild-type protein.	Histidine	12-15	cartilage oligomeric matrix protein	Homo sapiens	7-11
20416773-0	2009	Myosin is solubilized in a neutral and low ionic strength solution containing l-histidine.	Histidine	78-89	myosin heavy chain 14	Homo sapiens	0-6
14744774-6	2004	By using truncated versions of HRGP, we demonstrate that the isolated 150 amino acid-residue His/Pro-rich domain, which is also released by spontaneous proteolysis from purified HRGP, mediates the inhibitory effect on chemotaxis.	Histidine	93-96	histidine rich glycoprotein	Homo sapiens	31-35
14744774-6	2004	By using truncated versions of HRGP, we demonstrate that the isolated 150 amino acid-residue His/Pro-rich domain, which is also released by spontaneous proteolysis from purified HRGP, mediates the inhibitory effect on chemotaxis.	Histidine	93-96	histidine rich glycoprotein	Homo sapiens	178-182
20416773-2	2009	In this study, the behavior and morphology of myosin solubilized in a low ionic strength solution containing l-histidine (l-His) was investigated.	Histidine	109-120	myosin heavy chain 14	Homo sapiens	46-52
14984209-0	2004	Activation of carbonic anhydrase II by active-site incorporation of histidine analogs.	Histidine	68-77	carbonic anhydrase 2	Homo sapiens	14-35
20416773-2	2009	In this study, the behavior and morphology of myosin solubilized in a low ionic strength solution containing l-histidine (l-His) was investigated.	Histidine	122-127	myosin heavy chain 14	Homo sapiens	46-52
20416773-3	2009	More than 80% of myosin was solubilized in a low ionic strength solution with dialysis against a solution containing 1mM KCl and 5mM l-His.	Histidine	133-138	myosin heavy chain 14	Homo sapiens	17-23
20416773-4	2009	Transmission electron microscopy with rotary shadowing demonstrated that the rod of myosin in a low ionic strength solution containing l-His is longer than that of myosin in a high ionic strength solution.	Histidine	135-140	myosin heavy chain 14	Homo sapiens	84-90
15036292-1	2004	Neuroglobin displays a hexacoordination His-Fe-His in the absence of external ligands such as oxygen.	Histidine	40-44	neuroglobin	Homo sapiens	0-11
20416773-5	2009	The elongation of the myosin rod in a low ionic strength solution containing l-His would inhibit the formation of a filament, resulting in the solubilization of myosin.	Histidine	77-82	myosin heavy chain 14	Homo sapiens	22-28
15036292-7	2004	Mutation of specific cysteines, or reduction to break the S-S bond, led to a large decrease in the observed oxygen affinity of human neuroglobin, mainly due to a decrease in the histidine dissociation rate.	Histidine	178-187	neuroglobin	Homo sapiens	133-144
20416773-5	2009	The elongation of the myosin rod in a low ionic strength solution containing l-His would inhibit the formation of a filament, resulting in the solubilization of myosin.	Histidine	77-82	myosin heavy chain 14	Homo sapiens	161-167
19442270-4	2009	Herein we validate the use in vitro of recombinant 6 x His-tagged-PAI-2 lacking the intrahelical loop between C and D alpha-helices (PAI-2 Delta CD-loop) for these purposes.	Histidine	55-58	serpin family B member 2	Homo sapiens	66-71
15019487-3	2003	One of the main experimental strategies used for the study of myotoxic PLA2s is the traditional chemical modification of specific amino acid residues (His, Met, Lys, Tyr, Trp and others) and examination of the consequent effects upon the enzymatic, toxic and pharmacological activities.	Histidine	151-154	phospholipase A2 group IIA	Homo sapiens	71-76
19442270-4	2009	Herein we validate the use in vitro of recombinant 6 x His-tagged-PAI-2 lacking the intrahelical loop between C and D alpha-helices (PAI-2 Delta CD-loop) for these purposes.	Histidine	55-58	serpin family B member 2	Homo sapiens	133-138
14643929-7	2003	It is concluded that Sur2p is a membrane-bound hydroxylase that belongs to the diiron family of eight-histidine motif enzymes.	Histidine	102-111	sphingosine hydroxylase	Saccharomyces cerevisiae S288C	21-26
19246456-5	2009	Substitution of the three polar amino acid residues (His(46), Gln(50), and Gln(53)) within this motif with alanine abolishes the inhibitory effect of Angptl4 on LPL in vitro and also abrogates the ability of Angptl4 to elevate plasma triglyceride levels in mice.	Histidine	53-56	angiopoietin-like 4	Mus musculus	150-157
14534363-9	2003	In contrast, an antagonist rhodamine-Ac-Cys-Glu-His-(d-Nal)-Arg-Trp-Gly-Cys-Pro-Pro-Lys-Asp-NH2 (HS014) bound to and colocalized with MC4R-GFP on the cell surface and did not stimulate receptor internalization.	Histidine	48-51	melanocortin 4 receptor	Homo sapiens	134-138
19146426-8	2009	This His/Arg-18 mutation results in reduced affinity binding of human IAPP to insulin in comparison to rat IAPP as it is detected by surface plasmon resonance biosensor analysis.	Histidine	5-8	islet amyloid polypeptide	Rattus norvegicus	107-111
19028475-5	2009	Second, the Kvbeta subunits (AKR6A3, AKR6A5 and AKR6A9) which modulate opening of the voltage-gated potassium channel (Kv1) by oxidizing NADPH, have an Asn substituted for the His.	Histidine	176-179	potassium voltage-gated channel subfamily A regulatory beta subunit 1	Homo sapiens	29-35
14673502-6	2003	The results showed that the neural-inhibiting activity of xGATA-1b, but not hematopoiesis-inducing activity, was aborted because of deletion of Ser(168) and His(169) or point mutation of T(359)--&gt;A.	Histidine	157-160	GATA binding protein 1 S homeolog	Xenopus laevis	58-66
14673502-7	2003	So it is demonstrated for the first time that Ser(168) and His(169) or Thr(359)in xGATA-1b may be one of the structural basis for explanting the different function between xGATA-1b and xGATA-1a.	Histidine	59-62	GATA binding protein 1 S homeolog	Xenopus laevis	82-90
14584947-3	2003	To probe the receptor active conformation of the pharmacophore His-Phe-Arg-Trp in gamma-MSH, two different series of gamma-MSH analogues have been designed and synthesized and their biological activities determined at hMC3R, hMC4R, and hMC5R.	Histidine	63-66	melanocortin 4 receptor	Homo sapiens	225-230
14584947-3	2003	To probe the receptor active conformation of the pharmacophore His-Phe-Arg-Trp in gamma-MSH, two different series of gamma-MSH analogues have been designed and synthesized and their biological activities determined at hMC3R, hMC4R, and hMC5R.	Histidine	63-66	melanocortin 5 receptor	Homo sapiens	236-241
19028475-5	2009	Second, the Kvbeta subunits (AKR6A3, AKR6A5 and AKR6A9) which modulate opening of the voltage-gated potassium channel (Kv1) by oxidizing NADPH, have an Asn substituted for the His.	Histidine	176-179	potassium voltage-gated channel subfamily A regulatory beta subunit 2	Homo sapiens	37-43
12959987-0	2003	Regulation of glucagon-like peptide-1 receptor and calcium-sensing receptor signaling by L-histidine.	Histidine	89-100	glucagon-like peptide 1 receptor	Rattus norvegicus	14-46
12959987-0	2003	Regulation of glucagon-like peptide-1 receptor and calcium-sensing receptor signaling by L-histidine.	Histidine	89-100	calcium-sensing receptor	Rattus norvegicus	51-75
19212657-3	2009	Site-directed mutagenesis studies indicate that the proximal residue histidine 25 (His25) plays a key role in hHO-1 activity.	Histidine	69-78	heme oxygenase 1	Homo sapiens	110-115
12959987-4	2003	L-Histidine (L-His) increases the sensitivity of the CaSR to extracellular Ca2+ and potentiates glucose-dependent insulin secretion from INS-1 cells.	Histidine	0-11	calcium-sensing receptor	Rattus norvegicus	53-57
12959987-4	2003	L-Histidine (L-His) increases the sensitivity of the CaSR to extracellular Ca2+ and potentiates glucose-dependent insulin secretion from INS-1 cells.	Histidine	0-5	calcium-sensing receptor	Rattus norvegicus	53-57
12837132-8	2003	Taken together, the selectivity of Abz-HPGGPQ-EDN2ph to cathepsin K primarily depends on the S2 and S2" subsite specificities of cathepsin K and the ionization state of histidine at P3.	Histidine	169-178	endothelin 2	Homo sapiens	46-50
19132843-0	2009	Role of histidine-86 in the catalytic mechanism of ferredoxin:thioredoxin reductase.	Histidine	8-17	peroxiredoxin 5	Homo sapiens	62-83
14516201-4	2003	Strikingly, the GXIIB sPLA(2) has a mutation in the active site, replacing the canonical histidine by a leucine, suggesting that this sPLA(2) is catalytically inactive.	Histidine	89-98	phospholipase A2 group XIIB	Homo sapiens	16-21
19323056-15	2009	The BMP-1/HIS was present at higher level in control tissue, during II phase of the menstrual cycle and in postmenopausal state, whereas in the tumour tissue its lowest level was at II phase of the cycle.	Histidine	10-13	bone morphogenetic protein 1	Homo sapiens	4-9
14578150-7	2003	For XRCC1 codon 280 genotypes of Arg/His and His/His compared with the Arg/Arg genotype, the OR was 0.64 (95% CI, 0.43-0.96).	Histidine	45-48	X-ray repair cross complementing 1	Homo sapiens	4-9
14578150-7	2003	For XRCC1 codon 280 genotypes of Arg/His and His/His compared with the Arg/Arg genotype, the OR was 0.64 (95% CI, 0.43-0.96).	Histidine	45-48	X-ray repair cross complementing 1	Homo sapiens	4-9
19085910-3	2009	Studies using recombinant CBS indicated that CO binds to the prosthetic heme, stabilizing 6-coordinated CO-Fe(II)-histidine complex to block the activity, whereas nitric oxide (NO) forms 5-coordinated structure without inhibiting it.	Histidine	114-123	cystathionine beta-synthase	Mus musculus	26-29
12750065-7	2003	Hi+ mobility is therefore low in cardiac cells, a feature that may predispose them to the generation of pHi gradients in response to sarcolemmal acid/base transport or local cytoplasmic acid production.	Histidine	0-3	glucose-6-phosphate isomerase	Oryctolagus cuniculus	104-107
18354387-7	2009	With a non-synonymous G to A transition, rs2734849 produces an amino-acid change (arginine to histidine) in C-terminal ankyrin repeat domain of ANKK1.	Histidine	94-103	ankyrin repeat and kinase domain containing 1	Homo sapiens	144-149
14506148-7	2003	Four cases (25%) of SRCCC demonstrated the same A:T transversion at the third base position of K-ras codon 61 (CAA to CAT; Gln to His).	Histidine	130-133	KRAS proto-oncogene, GTPase	Homo sapiens	95-100
12941880-6	2003	These results support the view that ARR15 acts as a repressor that mediates a negative feedback loop in the cytokinin and AHK4-mediated His--&gt;Asp phosphorelay.	Histidine	136-139	response regulator 15	Arabidopsis thaliana	36-41
19238200-5	2009	METHODS AND FINDINGS: An ELISA assay was developed for measuring hepcidin serum concentration using a recombinant hepcidin25-His peptide and a polyclonal antibody against this peptide, which was able to identify native hepcidin.	Histidine	125-128	hepcidin antimicrobial peptide	Homo sapiens	65-73
12736264-7	2003	Consistent with this result, we showed that mutation of the final histidine had only a modest effect on DNA binding in the context of the full three-finger DNA-binding domain of basic Kruppel-like factor.	Histidine	66-75	Kruppel like factor 3	Homo sapiens	178-203
12771253-12	2003	This resulted in heterozygosity for normal tyrosine and variant histidine (ATTR Tyr69His) in affected family members.	Histidine	64-73	transthyretin	Homo sapiens	75-79
18823950-8	2008	Quenching of PCNA photo-crosslinking by histidine, and enhancement by deuterium oxide, suggest a role for singlet oxygen in the crosslinking.	Histidine	40-49	proliferating cell nuclear antigen	Homo sapiens	13-17
12719214-6	2003	Certain residues (namely Glu-72, His-88, His-90, Glu-92, and Tyr-116), play an important role in the binding process, as seen by the considerable pK(1/2) change of these residues upon dimer formation.	Histidine	33-36	prokineticin 1	Homo sapiens	146-152
12719214-6	2003	Certain residues (namely Glu-72, His-88, His-90, Glu-92, and Tyr-116), play an important role in the binding process, as seen by the considerable pK(1/2) change of these residues upon dimer formation.	Histidine	41-44	prokineticin 1	Homo sapiens	146-152
12719228-5	2003	Treatment of the hSlo1 channel with the histidine modifying agent diethyl pyrocarbonate also enhanced the hSlo1 currents and greatly diminished the internal pH sensitivity, suggesting that diethyl pyrocarbonate and low pH may work on the same effector mechanism.	Histidine	40-49	potassium calcium-activated channel subfamily M alpha 1	Homo sapiens	17-22
12719228-5	2003	Treatment of the hSlo1 channel with the histidine modifying agent diethyl pyrocarbonate also enhanced the hSlo1 currents and greatly diminished the internal pH sensitivity, suggesting that diethyl pyrocarbonate and low pH may work on the same effector mechanism.	Histidine	40-49	potassium calcium-activated channel subfamily M alpha 1	Homo sapiens	106-111
18835256-7	2008	Thus, the His residues of hRAMP2 and -3 differentially govern AM receptor function.	Histidine	10-13	receptor activity modifying protein 2	Homo sapiens	26-39
12833571-9	2003	It was also revealed that the TS1 binding to cytokeratin 8 and alphaTS1 respectively are partly overlapping; a histidine identified in TS1 is probably involved only in the interaction with alphaTS1.	Histidine	111-120	keratin 8	Homo sapiens	45-58
12684055-4	2003	By site-directed mutagenesis the second cysteine residue of the -CysGlyHisCys- motif in the thioredoxin domain of the enzyme protein was found to be the active site of the transamidation reaction and chemical modification of histidine in their motif blocked TGase activity.	Histidine	225-234	Thioredoxin	Caenorhabditis elegans	92-103
18844346-8	2008	The ligand binding analyses for the ferric and ferrous myoglobin suggest that the proximal histidine pulls the iron atom from the deformed core to reduce the interaction between the iron and exogenous ligands.	Histidine	91-100	myoglobin	Homo sapiens	55-64
12686130-3	2003	Histidine and phenylalanine ammonia-lyases (HAL and PAL) possess a catalytically essential electrophilic group which has been believed to be dehydroalanine for 30 years.	Histidine	0-9	histidine ammonia-lyase	Homo sapiens	44-47
12540839-0	2003	YC-1 facilitates release of the proximal His residue in the NO and CO complexes of soluble guanylate cyclase.	Histidine	41-44	RNA binding motif single stranded interacting protein 1	Homo sapiens	0-4
19137672-4	2008	We demonstrate that one of the NDP kinase isoforms dynamically interacts with the retinal rod G protein transducin (Gt) and phosphorylates its beta-subunit at histidine residue (His 266).	Histidine	159-168	cytidine/uridine monophosphate kinase 2	Homo sapiens	31-41
12540839-6	2003	These results revealed that YC-1 facilitated cleavage of the proximal His-iron bond and caused geometrical distortion of the five-coordinate NO-heme.	Histidine	70-73	RNA binding motif single stranded interacting protein 1	Homo sapiens	28-32
12540839-9	2003	These results indicate that YC-1 stimulates enzyme activity by weakening or cleaving the proximal His-iron bond in the CO complex as well as the NO complex.	Histidine	98-101	RNA binding motif single stranded interacting protein 1	Homo sapiens	28-32
19137672-4	2008	We demonstrate that one of the NDP kinase isoforms dynamically interacts with the retinal rod G protein transducin (Gt) and phosphorylates its beta-subunit at histidine residue (His 266).	Histidine	178-181	cytidine/uridine monophosphate kinase 2	Homo sapiens	31-41
12820376-1	2003	BACKGROUND: The intestinal mitosis-inhibiting peptide pyroglu-His-GlyOH (pEHG), inhibits normal intestinal epithelial cells and the human colon adenocarcinoma cell line HT-29 and increases the expression of c-fos (1).	Histidine	62-65	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	207-212
18797193-5	2008	We identified a permissive region in the pore-loop of repeat IV within the Ca(V)2.1 alpha(1) subunit, which allowed integration of several different tags (hemagluttinine [HA], double HA; 6-histidine tag [His], 9-His, bungarotoxin-binding site) without compromising alpha(1) subunit protein expression (in transfected tsA-201 cells) and function (after expression in X. laevis oocytes).	Histidine	204-207	adrenoceptor alpha 1D	Homo sapiens	84-92
18797193-5	2008	We identified a permissive region in the pore-loop of repeat IV within the Ca(V)2.1 alpha(1) subunit, which allowed integration of several different tags (hemagluttinine [HA], double HA; 6-histidine tag [His], 9-His, bungarotoxin-binding site) without compromising alpha(1) subunit protein expression (in transfected tsA-201 cells) and function (after expression in X. laevis oocytes).	Histidine	212-215	adrenoceptor alpha 1D	Homo sapiens	84-92
18765564-1	2008	The intracellular target of diphtheria toxin is a modified histidine residue, diphthamide, in the translation elongation factor, eEF2 (also known as EFT1).	Histidine	59-68	eukaryotic translation elongation factor 2	Mus musculus	129-133
12534281-9	2003	The catalytic triad of DP8 was shown to be Ser(739)-Asp (817)-His(849).	Histidine	62-65	dipeptidyl peptidase 8	Homo sapiens	23-26
18647362-4	2008	In HLA-B*4455, an nt exchange occurred in codon 9 of HLA-B*44020101, resulting in a change of the amino acid coding from tyrosine to histidine.	Histidine	133-142	major histocompatibility complex, class I, B	Homo sapiens	3-8
12409304-6	2003	To identify the Zn(2+) binding site responsible for the enhancement of agonist affinity in the beta(2)AR, we mutated histidines located in hydrophilic sequences bridging the seven transmembrane domains.	Histidine	117-127	adrenoceptor beta 2	Homo sapiens	95-104
18647362-4	2008	In HLA-B*4455, an nt exchange occurred in codon 9 of HLA-B*44020101, resulting in a change of the amino acid coding from tyrosine to histidine.	Histidine	133-142	major histocompatibility complex, class I, B	Homo sapiens	53-58
18571500-1	2008	A histidine-tagged recombinant N-terminal fragment of type-1 mouse liver diacylglycerol acyltransferase (DGAT; EC 2.3.1.20), MmDGAT1(1-95)His6, was expressed in Escherichia coli, and used to investigate possible acyl-CoA-binding properties.	Histidine	2-11	diacylglycerol O-acyltransferase 1	Mus musculus	73-103
12532276-0	2003	Two histidine residues in the juxta-membrane cytoplasmic domain of Na+/H+ exchanger isoform 3 (NHE3) determine the set point.	Histidine	4-13	solute carrier family 9 member A3	Homo sapiens	67-93
12532276-0	2003	Two histidine residues in the juxta-membrane cytoplasmic domain of Na+/H+ exchanger isoform 3 (NHE3) determine the set point.	Histidine	4-13	solute carrier family 9 member A3	Homo sapiens	95-99
12532276-2	2003	In the present study, the function of three highly conserved histidines in the juxtamembrane cytoplasmic domain of NHE3 was studied.	Histidine	61-71	solute carrier family 9 member A3	Homo sapiens	115-119
12532276-5	2003	However, the mutation in His-475 and His-499 significantly lowered NHE3 transport activity, whereas the mutation in H485 showed no apparent effect.	Histidine	25-28	solute carrier family 9 member A3	Homo sapiens	67-71
12532276-5	2003	However, the mutation in His-475 and His-499 significantly lowered NHE3 transport activity, whereas the mutation in H485 showed no apparent effect.	Histidine	37-40	solute carrier family 9 member A3	Homo sapiens	67-71
12532276-7	2003	The changes in set point by the mutations were further shifted to more acidic values by ATP depletion, indicating that the mechanism by which the mutations on the histidine residues altered the NHE3 set point differs from that caused by ATP depletion.	Histidine	163-172	solute carrier family 9 member A3	Homo sapiens	194-198
18571500-1	2008	A histidine-tagged recombinant N-terminal fragment of type-1 mouse liver diacylglycerol acyltransferase (DGAT; EC 2.3.1.20), MmDGAT1(1-95)His6, was expressed in Escherichia coli, and used to investigate possible acyl-CoA-binding properties.	Histidine	2-11	diacylglycerol O-acyltransferase 1	Mus musculus	105-109
18613721-7	2008	In previous studies HSMD (and HS Monte CarloHSMC) has been extended systematically to systems of increasing complexity, where the most recent is the seven-residue mobile loop, 304-310 (Gly-His-Gly-Ala-Gly-Gly-Ser) of the enzyme porcine pancreatic alpha-amylase modeled by the AMBER force field and AMBER with the implicit solvation GB/SA (paper I, Cheluvaraja, S.; Meirovitch, H. J. Chem.	Histidine	189-192	amylase alpha 2A	Homo sapiens	236-260
12432067-7	2002	In actin pull-down assays, the apparent K(d) of bacterially expressed his-tagged lasp-1 binding to F-actin was 2 micro M with a saturation stoichiometry of approximately 1:7.	Histidine	70-73	LIM and SH3 protein 1	Homo sapiens	81-87
12193598-6	2002	The Erf2p/Erf4p complex is required for Ras PAT activity, and mutations within conserved residues (Cys(189), His(201), and Cys(203)) of the Erf2p DHHC-CRD domain abolish Ras PAT activity.	Histidine	109-112	Shr5p	Saccharomyces cerevisiae S288C	10-15
12459266-5	2002	The presence of this motif, together with a conserved order and spacing of the Ser, Asp, and His residues that form the catalytic triad in DPP IV, places DPP9 in the "DPP IV gene family".	Histidine	93-96	dipeptidyl peptidase 9	Homo sapiens	154-158
12145281-12	2002	In contrast, two conserved histidines were important for thioredoxin-dependent activity, but were not involved in zinc binding.	Histidine	27-37	uncharacterized protein	Drosophila melanogaster	57-68
18480028-3	2008	Because ACAT enzymes have an intrinsic thioesterase activity, we hypothesized that by analogy with the thioesterase domain of fatty acid synthase, the active site of ACAT enzymes may comprise a catalytic triad of ser-his-asp (S-H-D) amino acid residues.	Histidine	217-220	acetyl-CoA acetyltransferase 1	Homo sapiens	8-12
12400683-1	2002	The maize response regulator genes ZmRR1 and ZmRR2 respond to cytokinin, and the translated products seem to be involved in nitrogen signal transduction mediated by cytokinin through the His-Asp phosphorelay.	Histidine	187-190	cytokinin response regulator 2	Zea mays	45-50
18480028-3	2008	Because ACAT enzymes have an intrinsic thioesterase activity, we hypothesized that by analogy with the thioesterase domain of fatty acid synthase, the active site of ACAT enzymes may comprise a catalytic triad of ser-his-asp (S-H-D) amino acid residues.	Histidine	217-220	acetyl-CoA acetyltransferase 1	Homo sapiens	166-170
18318660-10	2008	Exchanging His(99) of human uPA by a tyrosine residue, the corresponding residue in murine uPA, conferred mupain-1 susceptibility on to the latter.	Histidine	11-14	plasminogen activator, urokinase	Mus musculus	91-94
12213855-8	2002	However, a missense point mutation was detected in the SDHB gene: c.725G--&gt;A in exon 7, which alters a conserved arginine at amino acid position 242 to a histidine (R242H).	Histidine	157-166	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	55-59
18384506-1	2008	Histidine-tagged human cardiotrophin-1 (hCT-1), a recently discovered cytokine with excellent therapeutic potential, was expressed in tobacco chloroplasts under the transcriptional and translational control of two different promoters (rrn and psbA) and 5"-untranslated regions (5"-UTRs) (psbA and phage T7 gene 10).	Histidine	0-9	cardiotrophin 1	Homo sapiens	23-38
12163583-4	2002	Large-plaque revertants were observed readily following growth of the nsP4 Ser183 mutant at 40 degrees C. Fifteen revertants were characterized, and all had a mutation in the Asn374 codon of nsP1 that changed it to either a His or an Ile codon.	Histidine	224-227	SH2 domain containing 3A	Homo sapiens	191-195
12198576-3	2002	The recombinant metalloproteinase has an additional sequence of N-terminal 22 amino acids and C-terminal 8 amino acids (housing 6 histidines), both of which derived from the vector.	Histidine	130-140	metalloproteinase	Escherichia coli	16-33
18384506-1	2008	Histidine-tagged human cardiotrophin-1 (hCT-1), a recently discovered cytokine with excellent therapeutic potential, was expressed in tobacco chloroplasts under the transcriptional and translational control of two different promoters (rrn and psbA) and 5"-untranslated regions (5"-UTRs) (psbA and phage T7 gene 10).	Histidine	0-9	cardiotrophin 1	Homo sapiens	40-45
18561273-5	2008	Injection of His(6)-tagged very low density lipoprotein receptor (VLDLR-His(6)) constructs resulted in specific, oriented binding to the Ni(2+)-loaded bis-(nitrolotriacetic acid) (bis-NTA) groups to the re-exposed SAM areas.	Histidine	13-16	very low density lipoprotein receptor	Homo sapiens	27-64
12149456-3	2002	Here we identify mutations of Tyr-253 in the nucleotide-binding (P) loop of the Abl kinase domain to Phe or His in patients with advanced CML and acquired STI-571 resistance.	Histidine	108-111	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	80-83
18561273-5	2008	Injection of His(6)-tagged very low density lipoprotein receptor (VLDLR-His(6)) constructs resulted in specific, oriented binding to the Ni(2+)-loaded bis-(nitrolotriacetic acid) (bis-NTA) groups to the re-exposed SAM areas.	Histidine	13-16	very low density lipoprotein receptor	Homo sapiens	66-71
18596417-7	2008	Here, we summarize these findings with special emphasis on the histidine triad proteins Hint1 and Fhit and their repressive activity on the beta-catenin signaling function.	Histidine	63-72	catenin beta 1	Homo sapiens	140-152
12138266-6	2002	As a result, addition of protonated histidine at acidic pH(e) to Xenopus oocytes expressing rBAT creates an inward current which is paralleled by cytosolic acidification.	Histidine	36-45	bile acid CoA:amino acid N-acyltransferase	Rattus norvegicus	92-96
18437283-7	2008	The constructed model showed a typical alpha/beta-hydrolase fold, and confirmed the presence of a canonical catalytic triad consisting of Ser, Asp and His.	Histidine	151-154	PSHA_RS05245	Pseudoalteromonas haloplanktis TAC125	39-59
12121764-2	2002	KatGs, CCP and APXs contain identical amino acid triads in the heme pocket (distal Arg/Trp/His and proximal His/Trp/Asp), but differ dramatically in their reactivities towards hydrogen peroxide and various one-electron donors.	Histidine	91-94	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	7-10
12121764-2	2002	KatGs, CCP and APXs contain identical amino acid triads in the heme pocket (distal Arg/Trp/His and proximal His/Trp/Asp), but differ dramatically in their reactivities towards hydrogen peroxide and various one-electron donors.	Histidine	108-111	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	7-10
18261921-5	2008	Metal affinity purification yielded up to 18 microg of histidine-tagged annexin A5 fusions per ml processed cell culture supernatants.	Histidine	55-64	annexin A5	Homo sapiens	72-82
11970955-2	2002	HKa and particularly its His-Gly-Lys-rich domain 5 have been previously reported to exert anti-adhesive properties by binding to the extracellular matrix protein vitronectin (VN).	Histidine	25-28	vitronectin	Homo sapiens	162-173
11970955-2	2002	HKa and particularly its His-Gly-Lys-rich domain 5 have been previously reported to exert anti-adhesive properties by binding to the extracellular matrix protein vitronectin (VN).	Histidine	25-28	vitronectin	Homo sapiens	175-177
11993992-3	2002	In particular, homologous hydrogen-bonding networks involving a conserved basic residue (His 49 in Pdx, His 56 in Adx, Arg 49 in Tdx) are detailed.	Histidine	89-92	ferredoxin 1	Homo sapiens	114-117
18247577-4	2008	Mutating any of the four conserved histidine residues (His51, 147, 210, or 354) in hSVCT1 to alanine did not affect the apical membrane localization in polarized MDCK cells.	Histidine	35-44	solute carrier family 23 member 1	Homo sapiens	83-89
11993992-3	2002	In particular, homologous hydrogen-bonding networks involving a conserved basic residue (His 49 in Pdx, His 56 in Adx, Arg 49 in Tdx) are detailed.	Histidine	104-107	ferredoxin 1	Homo sapiens	114-117
18478981-9	2008	Assays of serially diluted His-Trx-VEGF1-100 by the established sandwich ELISA method showed that the linear range of the standard curve was 0.625-320 ng/mL, with the squared correlation coefficient R2 = 0.991.	Histidine	27-30	thioredoxin	Homo sapiens	31-34
11867614-3	2002	Nmp4 isoforms contain from 5 to 8 Cys(2)His(2) zinc fingers, an SH3-binding domain that overlaps with a putative AT-hook and a polyglutamine-alanine repeat (poly(QA)).	Histidine	40-43	zinc finger protein 384	Homo sapiens	0-4
11867614-4	2002	To determine the mechanistic significance of Cys(2)His(2) zinc finger association with this unusual consensus DNA binding element, we identified the Nmp4 DNA-binding and transcriptional activation domains.	Histidine	51-54	zinc finger protein 384	Homo sapiens	149-153
11913972-0	2002	Heterologous expression of an endogenous rat cytochrome b(5)/cytochrome b(5) reductase fusion protein: identification of histidines 62 and 85 as the heme axial ligands.	Histidine	121-131	cytochrome b5 type A	Rattus norvegicus	45-60
17997327-2	2008	We have used a pET-ubiquitin expression system to produce respiratory syncytial virus (RSV) NS1 protein in E. coli that contains a hexahistidine-tag on either the amino- or carboxyl-terminus (His(6)-NS1 and NS1-His(6), respectively).	Histidine	192-195	non-structural protein 1 (1C)	Respiratory syncytial virus	92-95
11913972-0	2002	Heterologous expression of an endogenous rat cytochrome b(5)/cytochrome b(5) reductase fusion protein: identification of histidines 62 and 85 as the heme axial ligands.	Histidine	121-131	cytochrome b5 type A	Rattus norvegicus	61-76
11835157-6	2002	We used the Hoffman degradation reaction to convert the amide groups of acrylamide to amine groups, and then we used ethylene glycol diglycidyl ether to attach biomolecules of interest inside the holes: secreted protein acidic and rich in cysteine (SPARC) peptide Lys-Gly-His-Lys (KGHK; angiogenic), thrombospondin-2 (TSP; antiangiogenic), or albumin (rat; neutral).	Histidine	272-275	secreted protein acidic and cysteine rich	Rattus norvegicus	203-247
17997327-2	2008	We have used a pET-ubiquitin expression system to produce respiratory syncytial virus (RSV) NS1 protein in E. coli that contains a hexahistidine-tag on either the amino- or carboxyl-terminus (His(6)-NS1 and NS1-His(6), respectively).	Histidine	211-214	non-structural protein 1 (1C)	Respiratory syncytial virus	92-95
20641593-0	2004	(99m)Tc-Anti-ED-B fibronectin single-chain antibody fragment L19-His (99m)Tc-Anti-ED-B fibronectin single-chain antibody fragment L19-His ((99m)Tc-L19-His) is a radiolabeled molecular imaging agent developed for single-photon emission computed tomography (SPECT) imaging of tumor angiogenesis and guidance for antiangiogenic treatment (1).	Histidine	65-68	skull development traits QTL 11	Mus musculus	61-64
11741991-4	2002	Its five tandem Cys(2)-His(2) zinc finger motifs exhibit the highest homology to those of members of the Gli and Zic subfamilies of Kruppel-like proteins.	Histidine	23-26	zinc finger protein of the cerebellum 1	Mus musculus	113-116
11781309-8	2002	Furthermore, mutations in this lysine and in a histidine residue that is also predicted to be important for pyridoxal 5"-phosphate binding to Lcb2p also dominantly inactivate SPT similar to the hereditary sensory neuropathy type 1-like mutations in Lcb1p.	Histidine	47-56	serine C-palmitoyltransferase LCB2	Saccharomyces cerevisiae S288C	142-147
20641593-0	2004	(99m)Tc-Anti-ED-B fibronectin single-chain antibody fragment L19-His (99m)Tc-Anti-ED-B fibronectin single-chain antibody fragment L19-His ((99m)Tc-L19-His) is a radiolabeled molecular imaging agent developed for single-photon emission computed tomography (SPECT) imaging of tumor angiogenesis and guidance for antiangiogenic treatment (1).	Histidine	65-68	skull development traits QTL 11	Mus musculus	130-133
20641593-0	2004	(99m)Tc-Anti-ED-B fibronectin single-chain antibody fragment L19-His (99m)Tc-Anti-ED-B fibronectin single-chain antibody fragment L19-His ((99m)Tc-L19-His) is a radiolabeled molecular imaging agent developed for single-photon emission computed tomography (SPECT) imaging of tumor angiogenesis and guidance for antiangiogenic treatment (1).	Histidine	65-68	skull development traits QTL 11	Mus musculus	130-133
11876652-0	2002	Alcaligenes xylosoxidans dissimilatory nitrite reductase: alanine substitution of the surface-exposed histidine 139l ligand of the type 1 copper center prevents electron transfer to the catalytic center.	Histidine	102-111	nitrite reductase large subunit	Achromobacter xylosoxidans	39-56
20641593-20	2004	(1) genetically introduced a (His)6 peptide sequence at the C-terminus of L19 to produce L19-His molecules.	Histidine	30-33	skull development traits QTL 11	Mus musculus	74-77
20641593-20	2004	(1) genetically introduced a (His)6 peptide sequence at the C-terminus of L19 to produce L19-His molecules.	Histidine	30-33	skull development traits QTL 11	Mus musculus	89-92
17936057-6	2008	Interestingly, the interaction of both isoforms with Shp2 in vivo was found using stable cell lines expressing eEF1A1-His or eEF1A2-His.	Histidine	132-135	eukaryotic translation elongation factor 1 alpha 2	Homo sapiens	125-131
11904683-3	2002	The deduced amino acid sequences of both Ciona C3-like proteins exhibit a canonical processing site for alpha and beta chains, a thioester site with an associated catalytic histidine and a convertase cleavage site, thus showing an overall similarity to the other C3 molecules already characterized.	Histidine	173-182	complement component C3	Ciona intestinalis	47-49
18037383-0	2007	Histidine residues in the IS3-IS4 loop are critical for nickel-sensitive inhibition of the Cav2.3 calcium channel.	Histidine	0-9	calcium voltage-gated channel subunit alpha1 E	Homo sapiens	91-97
18037383-2	2007	As in Cav3.2, two histidine residues are commonly found in the IS3-IS4 loops of mammalian Cav2.3 Ca2+ channels, which are also blocked by low micromolar concentrations of nickel.	Histidine	18-27	calcium voltage-gated channel subunit alpha1 E	Homo sapiens	90-96
17953656-7	2007	Other studies have shown that replacement of these histidines alpha(1) H101, alpha(2) H101, and alpha(3) H126 by arginine, as naturally present in alpha(4) and alpha(6) , leads to benzodiazepine insensitivity of these receptors.	Histidine	51-61	adrenoceptor alpha 1D	Homo sapiens	62-69
11895452-7	2002	Histidine at position 30 of the HLA-DQB1 gene was found in 22% of Group II but in none of Group I patients.	Histidine	0-9	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	32-40
11820929-4	2002	Among the six totally-conserved His residues of cytochrome b(561) in higher vertebrates, one is substituted with an Asn residue, indicating that His88 and His161 of bovine cytochrome b(561) play roles as heme b ligands at the extravesicular side.	Histidine	32-35	cytochrome b	Bos taurus	48-60
11820929-4	2002	Among the six totally-conserved His residues of cytochrome b(561) in higher vertebrates, one is substituted with an Asn residue, indicating that His88 and His161 of bovine cytochrome b(561) play roles as heme b ligands at the extravesicular side.	Histidine	32-35	cytochrome b	Bos taurus	172-184
17939707-0	2007	Comment on "ultrafast dynamics of myoglobin without the distal histidine: stimulated vibrational echo experiments and molecular dynamics simulations".	Histidine	63-72	myoglobin	Homo sapiens	34-43
11799199-8	2002	The enzyme activity of the VP1 unique region showed typical Ca(2+) dependency and could be inhibited by manoalide and 4-bromophenacylbromide, which bind covalently to lysine and histidine residues, respectively, as part of the active center of the enzyme.	Histidine	178-187	capsid protein 1	Human parvovirus B19	27-30
11571292-6	2001	The histidine-alanine-valine region of the FGFR has previously been implicated in the N-cadherin response, and a candidate interaction site has been identified in extracellular domain 4 of N-cadherin.	Histidine	4-13	cadherin 2	Homo sapiens	86-96
11571292-6	2001	The histidine-alanine-valine region of the FGFR has previously been implicated in the N-cadherin response, and a candidate interaction site has been identified in extracellular domain 4 of N-cadherin.	Histidine	4-13	cadherin 2	Homo sapiens	189-199
17932513-6	2007	It causes covalent oxidative crosslinking between the PCNA subunits through a histidine residue in the intersubunit domain.	Histidine	78-87	proliferating cell nuclear antigen	Homo sapiens	54-58
17905810-0	2007	Histidine cycle mechanism for the concerted proton/electron transfer from ascorbate to the cytosolic haem b centre of cytochrome b561: a unique machinery for the biological transmembrane electron transfer.	Histidine	0-9	cytochrome b561	Homo sapiens	118-133
11669611-5	2001	(i) Mature PsaD of spinach and PsaD of the prokaryotic caynobacterium Mastigocladus laminosus, both bearing a six-histidine tag at their C-termini, were overexpressed in Escherichia coli and purified to homogeneity.	Histidine	114-123	uncharacterized protein	Chlamydomonas reinhardtii	11-15
11669611-5	2001	(i) Mature PsaD of spinach and PsaD of the prokaryotic caynobacterium Mastigocladus laminosus, both bearing a six-histidine tag at their C-termini, were overexpressed in Escherichia coli and purified to homogeneity.	Histidine	114-123	uncharacterized protein	Chlamydomonas reinhardtii	31-35
17709260-2	2007	YUH1 was fused with the 6 histidine tag at the N-terminus (H6YUH1) or C-terminus (YUH1H6) and purified by an immobilized metal affinity chromatography with high purity.	Histidine	26-35	ubiquitin-specific protease YUH1	Saccharomyces cerevisiae S288C	0-4
11514573-7	2001	Thus, proton has both stimulatory and inhibitory effects on the Kir6.2 channels, which attribute to two sets of histidine residues in the C terminus.	Histidine	112-121	potassium inwardly rectifying channel subfamily J member 11	Homo sapiens	64-70
11600717-6	2001	A c-Fos/c-Jun complex was generated by co-renaturation and purified via a His-tag on the full-length human c-Fos.	Histidine	74-77	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	2-7
17869271-4	2007	Our data demonstrate that exchanging Cys for His and vice versa in the highly conserved Zn-coordinating HCCH motif disrupted Vif function and interaction with Cul5.	Histidine	45-48	cullin 5	Homo sapiens	159-163
11600717-6	2001	A c-Fos/c-Jun complex was generated by co-renaturation and purified via a His-tag on the full-length human c-Fos.	Histidine	74-77	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	8-13
11600717-6	2001	A c-Fos/c-Jun complex was generated by co-renaturation and purified via a His-tag on the full-length human c-Fos.	Histidine	74-77	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	107-112
11489879-2	2001	In an effort to identify amino acid residues near the phylloquinone binding sites, all tryptophans and histidines that are conserved between PsaA and PsaB in the region of the 10th and 11th transmembrane alpha-helices were mutated in Chlamydomonas reinhardtii.	Histidine	103-113	photosystem I P700 chlorophyll a apoprotein A2	Chlamydomonas reinhardtii	150-154
17928927-7	2007	The soluble His-LKB1 from RG accounted for 34.1% of total proteins and the yield of purified His-LKB1 was approximately 92 microg/ml.	Histidine	12-15	serine/threonine kinase 11	Homo sapiens	16-20
11579202-0	2001	Cloning and characterization of gonadotropin-inducible ovarian transcription factors (GIOT1 and -2) that are novel members of the (Cys)(2)-(His)(2)-type zinc finger protein family.	Histidine	140-143	gonadotropin inducible ovarian transcription factor 1	Rattus norvegicus	86-98
17928927-7	2007	The soluble His-LKB1 from RG accounted for 34.1% of total proteins and the yield of purified His-LKB1 was approximately 92 microg/ml.	Histidine	93-96	serine/threonine kinase 11	Homo sapiens	97-101
17928927-9	2007	The growth inhibitory ratio of the purified BL-derived and RG-derived His-LKB1 on hepatic carcinoma SMMC-7721 cells was 24.97% and 45.68%, respectively, and both could produce significant cell-cycle arrest.	Histidine	70-73	serine/threonine kinase 11	Homo sapiens	74-78
17521902-0	2007	Oriented immobilisation of anti-pneumolysin Fab through a histidine tag for electrochemical immunosensors.	Histidine	58-67	FA complementation group B	Homo sapiens	44-47
11562206-0	2001	A distal histidine mutant (H52Q) of yeast cytochrome c peroxidase catalyzes the oxidation of H(2)O(2) instead of its reduction.	Histidine	9-18	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	42-65
11562206-1	2001	A H52Q variant of yeast cytochrome c peroxidase (CcP), in which the distal histidine is replaced by glutamine, catalyzes oxidation of H(2)O(2) instead of reduction.	Histidine	75-84	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	24-47
11562206-1	2001	A H52Q variant of yeast cytochrome c peroxidase (CcP), in which the distal histidine is replaced by glutamine, catalyzes oxidation of H(2)O(2) instead of reduction.	Histidine	75-84	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	49-52
17521902-3	2007	The orientation of recombinant histidine-tagged Fab fragments of monoclonal anti-pneumolysin antibodies on gold films is evaluated.	Histidine	31-40	FA complementation group B	Homo sapiens	48-51
11551224-0	2001	Evidence for essential histidines in human pituitary glutaminyl cyclase.	Histidine	23-33	glutaminyl-peptide cyclotransferase	Homo sapiens	53-71
17702678-1	2007	The Arabidopsis MAP kinase 4 (MPK4) substrate MKS1 was expressed in Escherichia coli and purified, full-length, 6x histidine (His)-tagged MKS1 was phosphorylated in vitro by hemagglutinin (HA)-tagged MPK4 immuno-precipitated from plants.	Histidine	115-124	MAP kinase 4	Arabidopsis thaliana	16-28
17702678-1	2007	The Arabidopsis MAP kinase 4 (MPK4) substrate MKS1 was expressed in Escherichia coli and purified, full-length, 6x histidine (His)-tagged MKS1 was phosphorylated in vitro by hemagglutinin (HA)-tagged MPK4 immuno-precipitated from plants.	Histidine	115-124	MAP kinase 4	Arabidopsis thaliana	30-34
17702678-1	2007	The Arabidopsis MAP kinase 4 (MPK4) substrate MKS1 was expressed in Escherichia coli and purified, full-length, 6x histidine (His)-tagged MKS1 was phosphorylated in vitro by hemagglutinin (HA)-tagged MPK4 immuno-precipitated from plants.	Histidine	126-129	MAP kinase 4	Arabidopsis thaliana	16-28
11545602-12	2001	If the protonation state of a histidine, aspartate or glutamate protein side-chain is known, specific CSD-based maps for that protonation state are preferred over PDB-based maps which represent an ensemble of protonation states.	Histidine	30-39	cysteine sulfinic acid decarboxylase	Homo sapiens	102-105
17702678-1	2007	The Arabidopsis MAP kinase 4 (MPK4) substrate MKS1 was expressed in Escherichia coli and purified, full-length, 6x histidine (His)-tagged MKS1 was phosphorylated in vitro by hemagglutinin (HA)-tagged MPK4 immuno-precipitated from plants.	Histidine	126-129	MAP kinase 4	Arabidopsis thaliana	30-34
17589432-4	2007	Synthetic melanoma-associated antigen MART1 mRNA was formulated with a polyethylene glycol (PEG)ylated derivative of histidylated polylysine and L-histidine-(N,N-di-n-hexadecylamine)ethylamide liposomes (termed histidylated lipopolyplexes).	Histidine	145-156	melan-A	Mus musculus	38-43
11513747-0	2001	Regulation of SulA cleavage by Lon protease by the C-terminal amino acid of SulA, histidine.	Histidine	82-91	putative ATP-dependent Lon protease	Escherichia coli	31-34
11513747-4	2001	Substitution of the extreme C-terminal histidine residue with another amino acid led to marked accumulation and high stability of SulA in lon(+) cells.	Histidine	39-48	putative ATP-dependent Lon protease	Escherichia coli	138-141
11513747-7	2001	Histidine competitively inhibited the degradation of MBP-SulA by Lon, while other amino acids did not.	Histidine	0-9	putative ATP-dependent Lon protease	Escherichia coli	65-68
11513747-8	2001	These results suggest that the histidine residue at the extreme C-terminus of SulA is recognized specifically by Lon, leading to a high-affinity interaction between SulA and Lon.	Histidine	31-40	putative ATP-dependent Lon protease	Escherichia coli	113-116
11513747-8	2001	These results suggest that the histidine residue at the extreme C-terminus of SulA is recognized specifically by Lon, leading to a high-affinity interaction between SulA and Lon.	Histidine	31-40	putative ATP-dependent Lon protease	Escherichia coli	174-177
11683252-9	2001	This assay showed that histidine was pegylated preferentially at low pH levels with another protein, rh-Interleukin-10.	Histidine	23-32	interleukin 10	Homo sapiens	104-118
17587159-4	2007	Moreover, on SDS-polyacrylamide gel electrophoresis (SDS-PAGE) under nonreducing conditions, hexahistidine-tagged hGST P1-1 (His(6)-hGST P1-1) treated with 1 mM H(2)O(2) showed at least three extra bands, in addition to the native His(6)-hGST P1-1 subunit band.	Histidine	125-128	glutathione S-transferase pi 1	Homo sapiens	114-123
17587159-4	2007	Moreover, on SDS-polyacrylamide gel electrophoresis (SDS-PAGE) under nonreducing conditions, hexahistidine-tagged hGST P1-1 (His(6)-hGST P1-1) treated with 1 mM H(2)O(2) showed at least three extra bands, in addition to the native His(6)-hGST P1-1 subunit band.	Histidine	125-128	glutathione S-transferase pi 1	Homo sapiens	132-141
11528481-5	2001	Here we report, using a histidine scan of the initial C-linker of the CNG1 channel, stripes of sites producing Ni2+ potentiation or Ni2+ inhibition, separated by 50 degrees on an alpha-helix.	Histidine	24-33	cyclic nucleotide gated channel subunit alpha 1	Homo sapiens	70-74
17587159-4	2007	Moreover, on SDS-polyacrylamide gel electrophoresis (SDS-PAGE) under nonreducing conditions, hexahistidine-tagged hGST P1-1 (His(6)-hGST P1-1) treated with 1 mM H(2)O(2) showed at least three extra bands, in addition to the native His(6)-hGST P1-1 subunit band.	Histidine	231-234	glutathione S-transferase pi 1	Homo sapiens	114-123
17562347-9	2007	Our finding implicates functional importance of histidine in exchange of arginine at amino acid 481 of transferrin receptor 2 in iron homeostasis.	Histidine	48-57	transferrin receptor 2	Homo sapiens	103-125
11502179-1	2001	The amino-terminal ectodomain of the human TSH receptor has been expressed at the surface of CHO cells as a glycosylphosphatidylinositol-anchored molecule containing a 10-residue histidine tag close to its C terminus.	Histidine	179-188	thyroid stimulating hormone receptor	Homo sapiens	43-55
17567043-9	2007	This form was found to possess an effectively four-coordinate cob(II)alamin species that has neither water nor histidine coordinated to the cobalt center.	Histidine	111-120	metabolism of cobalamin associated B	Homo sapiens	62-65
11393758-2	2001	It describes the simple mixing of a 99mTc(I)-carbonyl compound [99mTc(OH2)3(CO)3]+ with a histidine-tagged somatostatin-dextran (SMS-Dx-His) conjugate.	Histidine	90-99	somatostatin	Homo sapiens	107-119
17473281-10	2007	From these two defined interactions, we predicted the complete INSL3/LGR8 primary binding site, including interactions between INSL3 His-B12 and LGR8 Trp-177, INSL3 Val-B19 and LGR8 Ile-179, and INSL3 Arg-B20 with LGR8 Asp-181 and Glu-229.	Histidine	133-136	insulin like 3	Homo sapiens	63-68
11489458-0	2001	Slowing of ERG current deactivation in NG108-15 cells by the histidine-specific reagent diethylpyrocarbonate.	Histidine	61-70	ETS transcription factor	Mus musculus	11-14
11489458-1	2001	The aim of this study was to explore and characterize the effect of the histidine-specific reagent diethylpyrocarbonate (DEPC) on the ERG (ether-a-go-go related gene) channels of whole-cell voltage-clamped NG108-15 neuroblastoma x glioma hybrid cells.	Histidine	72-81	ETS transcription factor	Mus musculus	134-137
11489458-1	2001	The aim of this study was to explore and characterize the effect of the histidine-specific reagent diethylpyrocarbonate (DEPC) on the ERG (ether-a-go-go related gene) channels of whole-cell voltage-clamped NG108-15 neuroblastoma x glioma hybrid cells.	Histidine	72-81	ETS transcription factor	Mus musculus	139-165
17473281-10	2007	From these two defined interactions, we predicted the complete INSL3/LGR8 primary binding site, including interactions between INSL3 His-B12 and LGR8 Trp-177, INSL3 Val-B19 and LGR8 Ile-179, and INSL3 Arg-B20 with LGR8 Asp-181 and Glu-229.	Histidine	133-136	relaxin family peptide receptor 2	Homo sapiens	69-73
11371465-1	2001	The gene encoding for bacterial cytochrome c-551 from Pseudomonas stutzeri substrain ZoBell has been mutated to convert the invariant sixth ligand methionine residue into histidine, creating the site-specific mutant M61H.	Histidine	171-180	cytochrome c3 family protein	Pseudomonas stutzeri	32-44
17473281-10	2007	From these two defined interactions, we predicted the complete INSL3/LGR8 primary binding site, including interactions between INSL3 His-B12 and LGR8 Trp-177, INSL3 Val-B19 and LGR8 Ile-179, and INSL3 Arg-B20 with LGR8 Asp-181 and Glu-229.	Histidine	133-136	insulin like 3	Homo sapiens	127-132
17473281-10	2007	From these two defined interactions, we predicted the complete INSL3/LGR8 primary binding site, including interactions between INSL3 His-B12 and LGR8 Trp-177, INSL3 Val-B19 and LGR8 Ile-179, and INSL3 Arg-B20 with LGR8 Asp-181 and Glu-229.	Histidine	133-136	relaxin family peptide receptor 2	Homo sapiens	145-149
17473281-10	2007	From these two defined interactions, we predicted the complete INSL3/LGR8 primary binding site, including interactions between INSL3 His-B12 and LGR8 Trp-177, INSL3 Val-B19 and LGR8 Ile-179, and INSL3 Arg-B20 with LGR8 Asp-181 and Glu-229.	Histidine	133-136	insulin like 3	Homo sapiens	127-132
17473281-10	2007	From these two defined interactions, we predicted the complete INSL3/LGR8 primary binding site, including interactions between INSL3 His-B12 and LGR8 Trp-177, INSL3 Val-B19 and LGR8 Ile-179, and INSL3 Arg-B20 with LGR8 Asp-181 and Glu-229.	Histidine	133-136	relaxin family peptide receptor 2	Homo sapiens	145-149
17473281-10	2007	From these two defined interactions, we predicted the complete INSL3/LGR8 primary binding site, including interactions between INSL3 His-B12 and LGR8 Trp-177, INSL3 Val-B19 and LGR8 Ile-179, and INSL3 Arg-B20 with LGR8 Asp-181 and Glu-229.	Histidine	133-136	insulin like 3	Homo sapiens	127-132
11279129-6	2001	Exchange of His-90 of AtHAL3a for Asn led to complete inactivation of the enzyme.	Histidine	12-15	HAL3-like protein A	Arabidopsis thaliana	22-29
17473281-10	2007	From these two defined interactions, we predicted the complete INSL3/LGR8 primary binding site, including interactions between INSL3 His-B12 and LGR8 Trp-177, INSL3 Val-B19 and LGR8 Ile-179, and INSL3 Arg-B20 with LGR8 Asp-181 and Glu-229.	Histidine	133-136	relaxin family peptide receptor 2	Homo sapiens	145-149
17461796-7	2007	In cell lines, PCSK9 also colocalized with the LDLR at the cell surface, requiring the presence of the C-terminal Cys/His-rich domain of PCSK9.	Histidine	118-121	proprotein convertase subtilisin/kexin type 9	Homo sapiens	15-20
11278438-1	2001	We report a novel phospholipase A(2) (PLA(2)), group XII (GXII) PLA(2), distinct from other cysteine-rich groups with a catalytic histidine motif, by its 20-kDa size and distribution of the 14 cysteine residues within the protein.	Histidine	130-139	phospholipase A2, group IB, pancreas	Mus musculus	18-36
11278438-1	2001	We report a novel phospholipase A(2) (PLA(2)), group XII (GXII) PLA(2), distinct from other cysteine-rich groups with a catalytic histidine motif, by its 20-kDa size and distribution of the 14 cysteine residues within the protein.	Histidine	130-139	phospholipase A2, group IB, pancreas	Mus musculus	38-44
11278438-1	2001	We report a novel phospholipase A(2) (PLA(2)), group XII (GXII) PLA(2), distinct from other cysteine-rich groups with a catalytic histidine motif, by its 20-kDa size and distribution of the 14 cysteine residues within the protein.	Histidine	130-139	phospholipase A2, group IB, pancreas	Mus musculus	64-70
11302935-17	2001	The reported tyrosine to histidine polymorphism in UGT2B7 does not alter the formation rate of epirubicin glucuronide, and undiscovered genetic polymorphisms in UGT2B7 might change the metabolic fate of this important anticancer agent.	Histidine	25-34	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	51-57
2691018-5	1989	A point mutation at this location corresponds to a substitution of histidine for glutamine in the N-ras gene product, p21.	Histidine	67-76	NRAS proto-oncogene, GTPase	Homo sapiens	98-103
17461796-7	2007	In cell lines, PCSK9 also colocalized with the LDLR at the cell surface, requiring the presence of the C-terminal Cys/His-rich domain of PCSK9.	Histidine	118-121	low density lipoprotein receptor	Homo sapiens	47-51
11336800-9	2001	Rather, the data suggest that the enhancement in cAMP potency arises from the formation of a ternary complex between [His(10)]-PTH(1-14), a zinc atom, and the extracellular loop/transmembrane domain region of the PTH-1 receptor.	Histidine	118-121	parathyroid hormone 1 receptor	Rattus norvegicus	213-227
17461796-7	2007	In cell lines, PCSK9 also colocalized with the LDLR at the cell surface, requiring the presence of the C-terminal Cys/His-rich domain of PCSK9.	Histidine	118-121	proprotein convertase subtilisin/kexin type 9	Homo sapiens	137-142
17477873-8	2007	RESULTS: Bioinformatic analysis of the Heterosigma akashiwo chloroplast genome sequence revealed the presence of a single two-component His-to-Asp (designated Tsg1/Trg1) pair in this stramenopile (golden-brown alga).	Histidine	136-139	ycf26	Heterosigma akashiwo	159-163
11274462-2	2001	In this paper we show that amino acid substitutions at the fully exposed Lys15 in bovine pancreatic trypsin inhibitor (BPTI) influenced the CD- and DSC-monitored stability: The T(den) difference between the least (P1 Trp) and the most stable (P1 His) mutant is 11.2 degrees C at pH 2.0.	Histidine	246-249	spleen trypsin inhibitor I	Bos taurus	119-123
17213471-8	2007	We conclude that SMS completely prevented HG/HI-induced TF activation in normal volunteers and may be of use to reduce the procoagulant state and acute vascular events in hyperinsulinemic insulin-resistant patients with type 2 diabetes.	Histidine	45-47	coagulation factor III, tissue factor	Homo sapiens	56-58
11255023-1	2001	Queuosine (Q) is a 7-deazaguanosine found in the first position of the anticodon of tRNAs that recognize NAU and NAC codons (Tyr, Asn, Asp and His).	Histidine	143-146	X-linked Kx blood group	Homo sapiens	113-116
2517482-0	1989	The histidines reacting with ethoxyformic anhydride in porcine pancreatic lipase: their relationships with enzyme activity.	Histidine	4-14	pancreatic lipase	Homo sapiens	63-80
2517482-1	1989	The activities of porcine pancreatic lipase (449 amino acid residues) toward two different substrates, p-nitrophenylacetate and tributyrylglycerol, and their dependence on histidine ethoxyformylation were studied.	Histidine	172-181	pancreatic lipase	Homo sapiens	26-43
17439156-8	2007	This is attributed to the fact that that low pH results in the protonation of the side chains of Asp, Glu, and His residues, which further disrupts the following four salt-bridge interactions stabilizing the alpha-beta interface of the native structure: Asp15-Arg53 (beta1-beta2), Glu21/20-Lys54 (helix-beta2), Asp40-Arg70 (helix-AS), and His43-Asp81 (beta2-AS).	Histidine	111-114	neuronal differentiation 1	Homo sapiens	273-278
2514797-0	1989	Role of histidine 64 in the catalytic mechanism of human carbonic anhydrase II studied with a site-specific mutant.	Histidine	8-17	carbonic anhydrase 2	Homo sapiens	57-78
2514797-1	1989	To test the hypothesis that histidine 64 in the active site of human carbonic anhydrase II functions as a proton-transfer group in the catalysis of CO2 hydration, we have studied a site-specific mutant having histidine 64 replaced by alanine, which cannot transfer protons.	Histidine	28-37	carbonic anhydrase 2	Homo sapiens	69-90
11038361-2	2001	The active site residue His(10), central in the catalytic mechanism of dPGM, is present as a phosphohistidine with occupancy of 0.28.	Histidine	24-27	Phosphoglucose mutase 1	Drosophila melanogaster	71-75
11038361-4	2001	The C-terminal 10-residue tail, which is not observed in previous dPGM structures, is well ordered and interacts with residues implicated in substrate binding; the displacement of a loop adjacent to the active histidine brings previously overlooked residues into positions where they may directly influence catalysis.	Histidine	210-219	Phosphoglucose mutase 1	Drosophila melanogaster	66-70
17439156-8	2007	This is attributed to the fact that that low pH results in the protonation of the side chains of Asp, Glu, and His residues, which further disrupts the following four salt-bridge interactions stabilizing the alpha-beta interface of the native structure: Asp15-Arg53 (beta1-beta2), Glu21/20-Lys54 (helix-beta2), Asp40-Arg70 (helix-AS), and His43-Asp81 (beta2-AS).	Histidine	111-114	neuronal differentiation 1	Homo sapiens	303-308
2501305-1	1989	We have reacted acrolein with human carbonic anhydrase II using conditions reported to result in maximal formylethylation of exposed histidine and lysine residues (Pocker, Y., and Janjic, N. (1988) J. Biol.	Histidine	133-142	carbonic anhydrase 2	Homo sapiens	36-57
11067847-11	2001	The data collectively indicate that His-12 and Asp-258, but not Cys-183 or Cys-281, are required for the PTP activity of PAcP.	Histidine	36-39	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	105-108
17439156-8	2007	This is attributed to the fact that that low pH results in the protonation of the side chains of Asp, Glu, and His residues, which further disrupts the following four salt-bridge interactions stabilizing the alpha-beta interface of the native structure: Asp15-Arg53 (beta1-beta2), Glu21/20-Lys54 (helix-beta2), Asp40-Arg70 (helix-AS), and His43-Asp81 (beta2-AS).	Histidine	111-114	neuronal differentiation 1	Homo sapiens	303-308
11067847-11	2001	The data collectively indicate that His-12 and Asp-258, but not Cys-183 or Cys-281, are required for the PTP activity of PAcP.	Histidine	36-39	acid phosphatase 3	Homo sapiens	121-125
2501305-9	1989	These results support the proposal of Pocker and Janjic and the suggested role of histidine 64 in carbonic anhydrase II as a proton shuttle residue that transfers a proton from zinc-bound water to buffer in solution.	Histidine	82-91	carbonic anhydrase 2	Homo sapiens	98-119
17126561-7	2007	The specific activity of the purified six-histidine-tagged recombinant PGI (rPGI-His(6)) was approximately 800U/mg of protein.	Histidine	42-51	glucose-6-phosphate isomerase	Mycobacterium tuberculosis H37Rv	71-74
17211673-0	2007	Roles of putative His-to-Asp signaling modules HPT-1 and RRG-2, on viability and sensitivity to osmotic and oxidative stresses in Neurospora crassa.	Histidine	18-21	hypoxanthine phosphoribosyltransferase	Saccharomyces cerevisiae S288C	47-52
2473157-6	1989	The encoded amino acid sequence of ECP shows 66% identity to that of EDN and 31% identity to that of human pancreatic ribonuclease, including conservation of the essential structural cysteine and cataytic lysine and histidine residues.	Histidine	216-225	ribonuclease A family member 3	Homo sapiens	35-38
11031263-7	2001	These surprising results are in marked contrast to the effects ascribed to the corresponding lower axial histidine ligands in the cobalamin-dependent enzymes glutamate mutase and methionine synthase.	Histidine	105-114	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	179-198
11185565-6	2000	In the case of CPR, the inhibitory effect is probably due to Cd2+ binding to the histidine residue of the apoenzyme, which, at physiological pH, acts as a nucleophilic group.	Histidine	81-90	cytochrome p450 oxidoreductase	Rattus norvegicus	15-18
11063570-6	2000	One major difference between the two CA isoforms, within the amino-terminal region, is a high content of histidine residues in CAII (His3, -4, -10, -15, -17) not found in CAI.	Histidine	105-114	carbonic anhydrase 2	Homo sapiens	127-131
17260955-9	2007	This interaction was confirmed with pulldown analyses in which the GST-PerCter protein selectively pulled down His-MREG and His-MREG selectively pulled down PerCter.	Histidine	111-114	melanoregulin	Homo sapiens	115-119
11063570-7	2000	Mutation of pairs of these histidines (and one lysine) in CAII to the analogous residues in CAI (H3P/H4D or K9D/H10K or H15Q/H17S), or combinations of these various double mutants, did not greatly affect binding between GST-Ct and the mutant CAII.	Histidine	27-37	carbonic anhydrase 2	Homo sapiens	58-62
11186130-3	2000	Two variant UGT2B7 cDNAs encoding enzymes with either His or Tyr at residue 268 have been isolated.	Histidine	54-57	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	12-18
2476788-1	1989	Recent studies show that substitutions for the His in position 12 of bombesin (Bn) are important in determining antagonist activity.	Histidine	47-50	gastrin releasing peptide	Homo sapiens	69-77
2476788-1	1989	Recent studies show that substitutions for the His in position 12 of bombesin (Bn) are important in determining antagonist activity.	Histidine	47-50	gastrin releasing peptide	Homo sapiens	79-81
17260955-9	2007	This interaction was confirmed with pulldown analyses in which the GST-PerCter protein selectively pulled down His-MREG and His-MREG selectively pulled down PerCter.	Histidine	124-127	melanoregulin	Homo sapiens	128-132
10978164-4	2000	The results suggest that, in addition to stabilizing the reactive intermediate compound I, the distal arginine plays an important role as a gatekeeper in the active site of CCP, controlling the access to the ferryl oxygen and the distal histidine.	Histidine	237-246	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	173-176
17108049-6	2007	Similar to the case for the Escherichia coli and human UNG enzymes, His-BKRF3 excised uracil from single-stranded DNA more efficiently than from double-stranded DNA and was inhibited by the purified bacteriophage PBS1 inhibitor Ugi.	Histidine	68-71	uracil-DNA glycosylase	Human gammaherpesvirus 4	72-77
10945855-4	2000	Using site-directed mutagenesis, we investigated whether mutating residues Trp-318 and His-319 to their corresponding residues in kappa- and delta-opioid receptors provides the molecular basis for mu/delta selectivity and mu/kappa selectivity.	Histidine	87-90	opioid receptor kappa 1	Homo sapiens	130-163
2539809-7	1989	By analogy with O2-carrying proteins and haem model compounds, the pH-dependent spectral changes of HRP and CCP were interpreted as indicative of the protonation of the N(epsilon) atom of the proximal histidine residue and of the cleavage of the Fe-N(epsilon) bond.	Histidine	201-210	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	108-111
2706085-11	1989	These results indicate that some of the cysteine residues in the polypeptide chain of THP can be replaced by histidine, suggesting a role of some cysteins in metal binding rather than intramolecular stabilization.	Histidine	109-118	uromodulin	Homo sapiens	86-89
17166179-3	2007	CNBP is mainly conformed by seven retroviral Cys-Cys-His-Cys zinc-knuckles and a glycine/arginine rich region box.	Histidine	53-56	CCHC-type zinc finger, nucleic acid binding protein a	Danio rerio	0-4
2540809-7	1989	Characterization by EPR spectroscopy of the oxochlorin-substituted cytochrome b5 yielded g values of 2.566, 2.375, and 1.756 and respective axial delta/lambda and rhombic V/lambda components of 2.857 and 3.287, indicating significant electronic distortion in the chlorin ring and an increase in electron donation from the axial histidine ligands.	Histidine	328-337	cytochrome b5 type A	Rattus norvegicus	67-80
3076850-5	1988	It has been shown that human VIP is cosynthesized with PHM (peptide with N-terminal histidine and C-terminal methionine amide, the human analogue of PHI) from the same large precursor protein (Itoh et al., 1983).	Histidine	84-93	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	55-58
10894741-4	2000	The fre gene was cloned, and the overexpressed protein, with a histidine tag at its N terminus, was purified to homogeneity by nickel affinity chromatography.	Histidine	63-72	NAD(P)H-flavin reductase	Salmonella enterica subsp. enterica serovar Typhimurium str. LT2	4-7
10908293-2	2000	In the beta(2)-adrenergic receptor the agonist binding site has previously been structurally and functionally exchanged with an activating metal-ion site located between AspIII:08-or a His residue introduced at this position in transmembrane domain (TM)-III-and a Cys residue substituted for AsnVII:06 in TM-VII.	Histidine	185-188	adrenoceptor beta 2	Homo sapiens	7-34
17068338-6	2006	We found that alterations at Glu(632) and His(661) of TAP2 significantly reduced peptide translocation and/or TAP-induced major histocompatibility complex class I surface expression.	Histidine	42-45	filamin B	Homo sapiens	54-57
17052986-0	2006	Seeing the process of histidine phosphorylation in human bisphosphoglycerate mutase.	Histidine	22-31	bisphosphoglycerate mutase	Homo sapiens	57-83
10873770-6	2000	SPI-3 protein lacking the N-terminal signal peptide was purified by means of an N-terminal His(10)-tag and gave complete inhibition in vitro of plasmin, uPA, and tPA and partial inhibition of factor Xa.	Histidine	91-94	serpin family B member 6	Homo sapiens	0-5
10972423-4	2000	A mutation in her DHAPAT complementary DNA resulted in the substitution of an arginine residue in the protein at position 211 by a histidine (R211H).	Histidine	131-140	glyceronephosphate O-acyltransferase	Homo sapiens	18-24
2851333-0	1988	Hydration of CO2 by carbonic anhydrase: intramolecular proton transfer between Zn2+-bound H2O and histidine 64 in human carbonic anhydrase II.	Histidine	98-107	carbonic anhydrase 2	Homo sapiens	120-141
2851333-1	1988	The energy barrier for the intramolecular proton transfer between zinc-bound water and His 64 in the active site of human carbonic anhydrase II (HCA II) has been studied at the partial retention of diatomic differential overlap (PRDDO) level.	Histidine	87-90	carbonic anhydrase 2	Homo sapiens	122-143
3292705-11	1988	It is concluded that LHRH degradation is primarily initiated by the membrane-bound form of endopeptidase-24.15 to yield pGlu-His-Trp-Ser-Tyr and to a lesser extent by endopeptidase-24.11 to yield pGlu-His-Trp-Ser-Tyr-Gly.	Histidine	125-128	thimet oligopeptidase 1	Mus musculus	91-110
17022785-2	2006	Our study revealed a novel, homoplasmic T11984C missense mutation in ND4 gene, which replaces a highly conserved amino acid tyrosine with histidine.	Histidine	138-147	mitochondrially encoded NADH dehydrogenase 4	Homo sapiens	69-72
10787436-8	2000	These data suggest that residues T123 and F382, located N-terminal of helices alpha 3-4 and alpha His, contribute specifically to the interaction of LCAT with HDL and possibly with its co-factor apoA-I.	Histidine	98-101	lecithin-cholesterol acyltransferase	Homo sapiens	149-153
16901746-4	2006	Using site-specific mutagenesis of the histidine precursor of diphthamide, the histidine residue of codon 715 in human EF-2 cDNA was substituted with one of four amino acid residue codons: leucine, methionine, asparagine or glutamine.	Histidine	39-48	eukaryotic translation elongation factor 2	Homo sapiens	119-123
10788626-3	2000	In non-primate GHs, His(170) replaces the homologous Asp(171), producing a repulsive interaction with Arg(43) of the primate receptor which was believed to reduce the attraction of non-primate GH for the human GH receptor, thus providing species specificity.	Histidine	20-23	growth hormone receptor	Homo sapiens	210-221
3065335-11	1988	Key amino acid residues, His(41), Asp(96), and Ser(190), required for catalytic activity and Asp (184) required for kallikrein-type specificity are completely conserved.	Histidine	25-28	kallikrein related peptidase 4	Homo sapiens	116-126
10704201-3	2000	The recombinant variants (i.e., H207N and E287Q) are enzymes in which the conserved amino acids histidine-207 and glutamate-287 of murine ferrochelatase were substituted with asparagine and glutamine, respectively.	Histidine	96-105	ferrochelatase	Mus musculus	138-152
16901746-4	2006	Using site-specific mutagenesis of the histidine precursor of diphthamide, the histidine residue of codon 715 in human EF-2 cDNA was substituted with one of four amino acid residue codons: leucine, methionine, asparagine or glutamine.	Histidine	79-88	eukaryotic translation elongation factor 2	Homo sapiens	119-123
17021082-2	2006	In order to facilitate armored RNA purification, a His6 tag was introduced into the loop region of the MS2 coat protein, which allows the exposure of multiple His tags on the surface during armored RNA assembly.	Histidine	51-54	MS2	Homo sapiens	103-106
10648402-2	2000	The vWf-binding site on GP Ib-IX-V is within the N-terminal 282 residues of GP Ibalpha, which consist of an N-terminal flanking sequence (His-1-Ile-35), 7 leucine-rich repeats (Leu-36-Ala-200), a C-terminal flank (Phe-201-Gly-268), and a sulfated tyrosine sequence (Asp-269-Glu-282).	Histidine	138-141	glycoprotein Ib platelet subunit alpha	Homo sapiens	76-86
3126084-1	1988	To test the hypothesis that histidine 64 in carbonic anhydrase II has a crucial role as a "proton shuttle group" during catalysis of CO2-HCO3- interconversion, this residue was replaced by lysine, glutamine, glutamic acid and alanine by site-directed mutagenesis.	Histidine	28-37	carbonic anhydrase 2	Homo sapiens	44-65
16931876-3	2006	We describe the 3 A resolution crystal structure of the highly conserved cysteine-histidine-rich domain of human UPF1 and show that it is a unique combination of three zinc-binding motifs arranged into two tandem modules related to the RING-box and U-box domains of ubiquitin ligases.	Histidine	82-91	UPF1 RNA helicase and ATPase	Homo sapiens	113-117
3276679-13	1988	Cleavages were found between B-9 and B-10 (Ser-His), B-10 and B-11 (His-Leu), B-14 and B-15 (Ala-Leu), B-13 and B-14 (Glu-Ala), B-16 and B-17 (Tyr-Leu), B-24 and B-25 (Phe-Phe), and B-25 and B-26 (Phe-Tyr).	Histidine	47-50	NADH:ubiquinone oxidoreductase subunit A3	Homo sapiens	29-41
10786622-4	2000	Mammalian SC5D was presumed as an integral membrane protein containing histidine residues conserved also in yeasts and plant.	Histidine	71-80	sterol-C5-desaturase	Homo sapiens	10-14
10627484-5	2000	Substitution of His for Arg at this site resulted in the blockage of Factor Xa cleavage, forming a dysfunctional molecule.	Histidine	16-19	coagulation factor X	Homo sapiens	69-78
16518858-5	2006	TAA90K-His bound to fibronectin, collagen IV, laminins-1, -5, and -10 and galectin-3 (Mac-2) but poorly to collagen I and galectin-1.	Histidine	7-10	galectin 3 binding protein	Homo sapiens	0-6
16518858-8	2006	However, at low concentrations, TAA90K-His enhanced galectin-3-mediated HT-29 cell adhesion while at high concentrations, it inhibited cell adhesion.	Histidine	39-42	galectin 3 binding protein	Homo sapiens	32-38
3289296-9	1988	The difference in the minimal active fragment between NMB and GRP-10 suggests that the amino acid of position 3 - NMB (Leu) and GRP-10 (His) - may play an important role in their biological activity.	Histidine	136-139	neuromedin B	Canis lupus familiaris	54-57
19661578-2	2006	An elastin-like-polypeptide (ELP)-based biopolymer consisting of a hexahistine cluster at each end (His(6)-ELP-His(6)) was generated and purified by taking advantage of the reversible phase transition property of ELP.	Histidine	100-103	nuclear receptor subfamily 5 group A member 1	Homo sapiens	3-27
2963625-5	1988	A tyrosine/histidine polymorphism was observed within the seventh homologous repeat unit of factor H.	Histidine	11-20	complement factor H	Homo sapiens	92-100
11030087-8	2000	Best activity was shown against hCA I and bCA IV, for which some of the new compounds (such as the Lys, Arg, His or the dipeptide derivatives) showed affinities in the 2-12 nm range (h = human; b = bovine isozymes).	Histidine	109-112	carbonic anhydrase 1	Homo sapiens	32-37
10574744-3	1999	The peptide sequence for Drosophila leucokinin (DLK) was determined as Asn-Ser-Val-Val-Leu-Gly-Lys-Lys-Gln-Arg-Phe-His-Ser-Trp-Gly-amide, making it the longest member of the family characterized to date.	Histidine	115-118	Leucokinin	Drosophila melanogaster	36-46
19661578-2	2006	An elastin-like-polypeptide (ELP)-based biopolymer consisting of a hexahistine cluster at each end (His(6)-ELP-His(6)) was generated and purified by taking advantage of the reversible phase transition property of ELP.	Histidine	100-103	nuclear receptor subfamily 5 group A member 1	Homo sapiens	29-32
10574744-3	1999	The peptide sequence for Drosophila leucokinin (DLK) was determined as Asn-Ser-Val-Val-Leu-Gly-Lys-Lys-Gln-Arg-Phe-His-Ser-Trp-Gly-amide, making it the longest member of the family characterized to date.	Histidine	115-118	Leucokinin	Drosophila melanogaster	48-51
2827651-1	1987	We synthesized a hexapeptide, Gly-His-His-Pro-His-Gly, previously identified as a tandem motif in the histidine-rich glycoprotein (HRG) which has multiple heme-binding sites.	Histidine	34-37	histidine rich glycoprotein	Homo sapiens	102-129
2827651-1	1987	We synthesized a hexapeptide, Gly-His-His-Pro-His-Gly, previously identified as a tandem motif in the histidine-rich glycoprotein (HRG) which has multiple heme-binding sites.	Histidine	34-37	histidine rich glycoprotein	Homo sapiens	131-134
10625445-4	1999	The displacement from an interface with cytochrome c(1) in native crystals to an interface with cytochrome b is induced by stigmatellin or 5-n-undecyl-6-hydroxy-4,7-dioxobenzothiazole (UHDBT) and involves ligand formation between His-161 of the [2Fe-2S] binding cluster and the inhibitor.	Histidine	230-233	CYTB	Gallus gallus	96-108
19661578-2	2006	An elastin-like-polypeptide (ELP)-based biopolymer consisting of a hexahistine cluster at each end (His(6)-ELP-His(6)) was generated and purified by taking advantage of the reversible phase transition property of ELP.	Histidine	111-114	nuclear receptor subfamily 5 group A member 1	Homo sapiens	3-27
19661578-2	2006	An elastin-like-polypeptide (ELP)-based biopolymer consisting of a hexahistine cluster at each end (His(6)-ELP-His(6)) was generated and purified by taking advantage of the reversible phase transition property of ELP.	Histidine	111-114	nuclear receptor subfamily 5 group A member 1	Homo sapiens	29-32
19661578-2	2006	An elastin-like-polypeptide (ELP)-based biopolymer consisting of a hexahistine cluster at each end (His(6)-ELP-His(6)) was generated and purified by taking advantage of the reversible phase transition property of ELP.	Histidine	111-114	nuclear receptor subfamily 5 group A member 1	Homo sapiens	107-110
10551831-0	1999	Proton transfer from histidine 244 may facilitate the 1,2 rearrangement reaction in coenzyme B(12)-dependent methylmalonyl-CoA mutase.	Histidine	21-30	methylmalonyl-CoA mutase	Homo sapiens	109-133
2826144-5	1987	In unliganded methemoglobin pK1, which is associated with carboxylic acid groups, ranges between 4.0 and 5.5 for the three methemoglobins; pK2, which is associated with histidines and terminal amino groups, ranges from 6.2 to 6.7.	Histidine	169-179	prokineticin 2	Homo sapiens	139-142
10549857-1	1999	The variable regions of heavy- and light-chains of mouse monoclonal antibody 196-14 toward ovarian cancer-associated antigen CA125 were linked with a peptide linker (GSTSGSGKSSEGKG) and a histidine tag was attached at the carboxyl terminal.	Histidine	188-197	mucin 16, cell surface associated	Homo sapiens	125-130
19661578-2	2006	An elastin-like-polypeptide (ELP)-based biopolymer consisting of a hexahistine cluster at each end (His(6)-ELP-His(6)) was generated and purified by taking advantage of the reversible phase transition property of ELP.	Histidine	111-114	nuclear receptor subfamily 5 group A member 1	Homo sapiens	107-110
16484588-3	2006	To test the mechanism of its action, we constructed mutant forms of c-Mpl; murine c-Mpl(L490H) dis-played a response to NIP-004, whereas human c-Mpl(H499L) lost this response, indicating that histidine in the transmembrane domain of c-Mpl is essential for its activity.	Histidine	192-201	myeloproliferative leukemia virus oncogene	Mus musculus	68-73
10504417-6	1999	Both the unmodified and the partially purified His-tagged p94 bound calcium with high affinity, and their autolytic activity required Ca2+.	Histidine	47-50	calpain 3	Homo sapiens	58-61
10582332-4	1999	Namely, a [2Fe-2S] cluster is a prosthetic group in mammalian ferrochelatase, a conserved and essential histidine residue appears to be involved in the binding of the metal substrate and a conserved glutamate residue has been proposed to have a catalytic role.	Histidine	104-113	ferrochelatase	Homo sapiens	62-76
2821259-7	1987	Furthermore, pH dependency studies showed that, at lower pH, change in the affinities for the PBR ligands is a property of the receptor, substantiating the hypothesis that a histidine moiety on the PBR is the most likely site for covalent bond formation, whereas, at higher pH, the observed changes in affinities can be attributed to properties of the compounds.	Histidine	174-183	translocator protein	Homo sapiens	94-97
2821259-7	1987	Furthermore, pH dependency studies showed that, at lower pH, change in the affinities for the PBR ligands is a property of the receptor, substantiating the hypothesis that a histidine moiety on the PBR is the most likely site for covalent bond formation, whereas, at higher pH, the observed changes in affinities can be attributed to properties of the compounds.	Histidine	174-183	translocator protein	Homo sapiens	198-201
16484588-3	2006	To test the mechanism of its action, we constructed mutant forms of c-Mpl; murine c-Mpl(L490H) dis-played a response to NIP-004, whereas human c-Mpl(H499L) lost this response, indicating that histidine in the transmembrane domain of c-Mpl is essential for its activity.	Histidine	192-201	myeloproliferative leukemia virus oncogene	Mus musculus	82-87
10582345-1	1999	Basic Kruppel-like Factor (BKLF) is a recently recognized member of a small group of transcription factors that bind CACCC motifs in DNA, by means of three highly conserved C-terminal Kruppel-like (typically Cys-X2-4-Cys-X12-His-X3-4-His) zinc fingers.	Histidine	225-228	Kruppel-like factor 3 (basic)	Mus musculus	0-25
10582345-1	1999	Basic Kruppel-like Factor (BKLF) is a recently recognized member of a small group of transcription factors that bind CACCC motifs in DNA, by means of three highly conserved C-terminal Kruppel-like (typically Cys-X2-4-Cys-X12-His-X3-4-His) zinc fingers.	Histidine	225-228	Kruppel-like factor 3 (basic)	Mus musculus	27-31
16817893-9	2006	Enzymatic analysis of the purified hexamer His-AtUGD1 revealed that AtUGD1 activity is strongly inhibited by UDP-D-xylose, suggesting that AtUGD1 maintains intracellular levels of UDP-D-glucose in cooperation with AtUXS3 via the inhibition of AtUGD1 by UDP-D-xylose.	Histidine	43-46	UDP-glucose dehydrogenase 1	Arabidopsis thaliana	47-53
10556554-3	1999	A mutant of carbonic anhydrase II containing the replacement His-64--&gt;Ala, which removes the prominent histidine proton shuttle (with pK(a) near 7), allows better observation of these basic groups.	Histidine	61-64	carbonic anhydrase 2	Homo sapiens	12-33
10556554-3	1999	A mutant of carbonic anhydrase II containing the replacement His-64--&gt;Ala, which removes the prominent histidine proton shuttle (with pK(a) near 7), allows better observation of these basic groups.	Histidine	106-115	carbonic anhydrase 2	Homo sapiens	12-33
3302105-7	1987	The N-terminal amino acid sequence of CSF gamma-Aogen was Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-Leu-Leu-Val-Tyr-Ser-Lys-Ser-Ser-(X)-Glu- .	Histidine	78-81	colony stimulating factor 2	Canis lupus familiaris	38-41
16817893-9	2006	Enzymatic analysis of the purified hexamer His-AtUGD1 revealed that AtUGD1 activity is strongly inhibited by UDP-D-xylose, suggesting that AtUGD1 maintains intracellular levels of UDP-D-glucose in cooperation with AtUXS3 via the inhibition of AtUGD1 by UDP-D-xylose.	Histidine	43-46	UDP-glucose dehydrogenase 1	Arabidopsis thaliana	68-74
10493588-1	1999	The extracellular portions of the chains that comprise the human type I interferon receptor, IFNAR1 and IFNAR2, have been expressed and purified as recombinant soluble His-tagged proteins, and their interactions with each other and with human interferon-beta-1a (IFN-beta-1a) were studied by gel filtration and by cross-linking.	Histidine	168-171	interferon alpha and beta receptor subunit 2	Homo sapiens	104-110
16817893-9	2006	Enzymatic analysis of the purified hexamer His-AtUGD1 revealed that AtUGD1 activity is strongly inhibited by UDP-D-xylose, suggesting that AtUGD1 maintains intracellular levels of UDP-D-glucose in cooperation with AtUXS3 via the inhibition of AtUGD1 by UDP-D-xylose.	Histidine	43-46	UDP-glucose dehydrogenase 1	Arabidopsis thaliana	68-74
10441372-4	1999	We identified a target molecule of SHP-1 by comparing the phosphorylation of major cellular substrates following in vitro phosphorylation of Jurkat cell lysates in the presence and absence of the His-CytKIR in this cell-free model system.	Histidine	196-199	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	35-40
16817893-9	2006	Enzymatic analysis of the purified hexamer His-AtUGD1 revealed that AtUGD1 activity is strongly inhibited by UDP-D-xylose, suggesting that AtUGD1 maintains intracellular levels of UDP-D-glucose in cooperation with AtUXS3 via the inhibition of AtUGD1 by UDP-D-xylose.	Histidine	43-46	UDP-glucose dehydrogenase 1	Arabidopsis thaliana	68-74
10441372-5	1999	The His-CytKIR was tyrosine phosphorylated by Lck in vitro, and the phosphorylated His-CytKIR recruited SHP-1.	Histidine	4-7	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	104-109
3478091-0	1987	Evidence for an essential histidine in neutral endopeptidase 24.11.	Histidine	26-35	membrane metallo-endopeptidase	Rattus norvegicus	39-66
10441372-7	1999	However, PLC-gamma exhibited no decrease in phosphorylation when SHP-1 or Lck was depleted or deficient in this reaction mixture, suggesting that the SHP-1 recruited by the phosphorylated His-CytKIR directly mediate the dephosphorylation of PLC-gamma.	Histidine	188-191	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	150-155
16595170-4	2006	Unexpectedly, the naturally occurring mutation of Arg(3.50) to His in mouse GPR33 showed no difference from the wild-type receptor in several functional tests.	Histidine	63-66	G protein-coupled receptor 33	Mus musculus	76-81
10228174-2	1999	We have determined the solution structure of human eIF1 with an N-terminal His tag using NMR spectroscopy.	Histidine	75-78	eukaryotic translation initiation factor 1	Homo sapiens	51-55
3103690-4	1987	We now confirm the involvement of serine and histidine in catalysing the phospholipase A2 action of lecithin-cholesterol acyltransferase by demonstrating the inhibition of this activity by phenylboronic acid (Ki = 1.23 mM) and m-aminophenylboronic acid (Ki = 2.32 mM), inhibitors of known serine/histidine hydrolases.	Histidine	45-54	lecithin-cholesterol acyltransferase	Homo sapiens	100-136
17197349-9	2006	Other than histidine 118 residue (amino acid sequence 118: histidine) concerned with NDP kinase activity of nm23-H1, serine 120 (amino acid sequence 120: serine) related activity of histidine-dependent protein phosphotransfer was recently reported to be responsible for its biological suppressive effects.	Histidine	59-68	cytidine/uridine monophosphate kinase 2	Homo sapiens	85-95
10322033-1	1999	The deduced product of the Bacillus subtilis ytvP gene is similar to that of ORF13, a gene of unknown function in the Lactococcus lactis histidine biosynthesis operon.	Histidine	137-146	hypothetical protein	Bacillus subtilis	77-82
16678114-0	2006	RAP uses a histidine switch to regulate its interaction with LRP in the ER and Golgi.	Histidine	11-20	LDL receptor related protein associated protein 1	Homo sapiens	0-3
10096879-3	1999	Using a human methemoglobin alpha beta dimer, it has been shown that at 235 K after 61 ps, a rearrangement occurs in the alpha-chain corresponding to the formation of a bond with the distal histidine.	Histidine	190-199	hemoglobin subunit gamma 2	Homo sapiens	14-27
3818601-4	1987	Based upon current models for the secondary structure of cytochrome b, the altered amino acid lies in close proximity to one of the invariant histidine residues involved in binding the heme groups.	Histidine	142-151	mitochondrially encoded cytochrome b	Homo sapiens	57-69
16678114-4	2006	The solution structure of RAP-D3 domain presented here reveals a striking increase in positively charged residues on the surface of this RAP domain due to protonation of solvent-exposed histidine sidechains as the pH is reduced from a near neutral pH of the ER to the acidic pH of the Golgi.	Histidine	186-195	LDL receptor related protein associated protein 1	Homo sapiens	26-29
16678114-4	2006	The solution structure of RAP-D3 domain presented here reveals a striking increase in positively charged residues on the surface of this RAP domain due to protonation of solvent-exposed histidine sidechains as the pH is reduced from a near neutral pH of the ER to the acidic pH of the Golgi.	Histidine	186-195	LDL receptor related protein associated protein 1	Homo sapiens	137-140
16678114-5	2006	Structure-based mutagenesis studies in vitro and in cells confirm that the protonation of histidine residues as a consequence of the pH changes modulate the binding/release of RAP from LRP.	Histidine	90-99	LDL receptor related protein associated protein 1	Homo sapiens	176-179
16648478-1	2006	The translation elongation factor 2 in eukaryotes (eEF-2) contains a unique posttranslationally modified histidine residue, termed diphthamide, which serves as the only target for diphtheria toxin and Pseudomonas aeruginosa exotoxin A.	Histidine	105-114	eukaryotic translation elongation factor 2	Mus musculus	51-56
3095115-7	1986	Like human apo A-I, rabbit apo A-I contains very little histidine (2) and methionine (1); it does however have two residues of isoleucine.	Histidine	56-65	apolipoprotein A-I	Oryctolagus cuniculus	27-34
10201402-5	1999	The enzyme contains a lipase-like catalytic triad, Ser 202, Asp 308 and His 338, consistent with mutational studies that implicate the homologous Ser 424, Asp 693 and His 723 in the catalytic triad in human HSL.	Histidine	72-75	lipase E, hormone sensitive type	Homo sapiens	207-210
10201402-5	1999	The enzyme contains a lipase-like catalytic triad, Ser 202, Asp 308 and His 338, consistent with mutational studies that implicate the homologous Ser 424, Asp 693 and His 723 in the catalytic triad in human HSL.	Histidine	167-170	lipase E, hormone sensitive type	Homo sapiens	207-210
10022827-6	1999	Systematic mutagenesis revealed a titratable C-terminal histidine residue (H216) in Kir6.2 to be the structural determinant, and electrostatic interaction between this residue and polyamines was shown to be the molecular mechanism underlying pH-dependent rectification.	Histidine	56-65	potassium inwardly rectifying channel subfamily J member 11	Homo sapiens	84-90
3098281-1	1986	Two model peptides Boc-Asp-Pro-Aib-X-NHMe [X = His (1) and X = Lys (2)] were synthesized to simulate intramolecular electrostatic interactions between ionizable side chains.	Histidine	47-50	ANIB1	Homo sapiens	31-34
16579629-4	2006	To begin to address this problem, we developed an affinity pull-down/mass spectrometry method to characterize the primary structure of histidine-tagged alpha-synuclein isolated from catecholaminergic neurons.	Histidine	135-144	synuclein alpha	Homo sapiens	152-167
3707967-4	1986	Radioiodination of wheat germ calmodulin, which contains a single tyrosine residue (Tyr-139), showed that only TM2 was labeled by 125I on the Tyr-139 residue and also on the His-108 residue (radiolabeled monoiodotyrosine, diiodotyrosine and monoiodohistidine being present).	Histidine	174-177	CaM5	Triticum aestivum	30-40
9882312-2	1999	The F13L protein contains a variant of the HKD (His-Lys-Asp) motif, which is conserved in numerous enzymes of phospholipid metabolism.	Histidine	48-51	palmytilated EEV membrane glycoprotein	Vaccinia virus	4-8
3518635-3	1986	A comparison with other known insulin structures suggests that cat insulin has an uncommon property: it appears to be the only insulin found so far with His at position A18.	Histidine	153-156	immunoglobulin kappa variable 2-29	Homo sapiens	169-172
16595957-7	2006	This 1B-His binding assay will be useful not only for the determination of Gb3 content, but also for screening for the compounds which inhibit the toxin-binding to Gb3.	Histidine	8-11	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	75-78
10234805-8	1999	An N-cadherin peptidomimic containing the His-Ala-Val sequence to abrogate homotypic N-cadherin interactions inhibited chondrogenesis in a concentration-dependent manner.	Histidine	42-45	cadherin 2	Mus musculus	3-13
16595957-7	2006	This 1B-His binding assay will be useful not only for the determination of Gb3 content, but also for screening for the compounds which inhibit the toxin-binding to Gb3.	Histidine	8-11	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	164-167
10780438-2	1999	As a result, peptides with Thr/Glu/His and Gln/Asp were obtained in binding of DNA core and AP2, respectively.	Histidine	35-38	transcription factor AP-2 alpha	Homo sapiens	92-95
3707913-3	1986	The microenvironments of the histidines in three isoforms of Ca(II)-bound parvalbumin (carp, pI = 4.25; pike, pI = 5.00; rat, pI = 5.50) have been examined with 1H NMR techniques to probe their protonation characteristics and photochemically induced dynamic nuclear polarizability (photo-CIDNP).	Histidine	29-39	parvalbumin	Rattus norvegicus	74-85
16289537-4	2006	The hPHT1 full-sequence was amplified from BeWo cells, inserted into the pcDNA3.1-V5/His TOPO plasmid and transiently transfected into COS-7 cells to investigate the uptake kinetics of [3H]histidine and [3H]carnosine.	Histidine	189-198	solute carrier family 15 member 4	Homo sapiens	4-9
2421767-2	1986	Anti-fibrin antibody 59D8 which had been elicited by immunization with human beta(1-7) peptide, Gly-His-Arg-Pro-Leu-Asp-Lys, binds to human and canine fibrins but not to bovine, ovine, or porcine fibrins.	Histidine	100-103	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	77-85
3956484-7	1986	It is proposed that the Ser-Phe combination present in L16, L11 and L6 is involved in transesterification in addition to the single histidine in L16.	Histidine	132-141	immunoglobulin kappa variable 1-6	Homo sapiens	60-63
9860943-10	1998	By using a fumagillin analog tagged with fluorescein, His-231 in MetAP2 was identified as the residue that is covalently modified by fumagillin.	Histidine	54-57	methionyl aminopeptidase 2	Homo sapiens	65-71
9860943-11	1998	Site-directed mutagenesis of His-231 demonstrated its importance for the catalytic activity of MetAP2 and confirmed that the same residue is covalently modified by fumagillin.	Histidine	29-32	methionyl aminopeptidase 2	Homo sapiens	95-101
16289537-7	2006	Histidine and carnosine uptake was linear in hPHT1-COS-7 cells over 15 min and was found to be pH-dependent.	Histidine	0-9	solute carrier family 15 member 4	Homo sapiens	45-50
9822691-4	1998	hIIa-PLA2 contains 13 lysines, 2 histidines, and 10 arginines that fall into 10 clusters.	Histidine	33-43	phospholipase A2 group IIA	Homo sapiens	5-9
16533060-7	2006	Furthermore, when such bilayers were immobilized onto solid supports, they efficiently captured histidine-tagged soluble tissue factor directly from crude culture supernatants, with full biological activity, obviating the need for purification or laborious membrane reconstitution procedures.	Histidine	96-105	coagulation factor III, tissue factor	Homo sapiens	121-134
9812990-8	1998	However, the leucine- and histidine-induced alterations in global protein synthesis and eIF2B activity were maintained in the presence of the hormone.	Histidine	26-35	eukaryotic translation initiation factor 2B subunit delta	Homo sapiens	88-93
9812990-9	1998	Overall, the results suggest that both leucine and histidine regulate global protein synthesis through modulation of eIF2B activity.	Histidine	51-60	eukaryotic translation initiation factor 2B subunit delta	Homo sapiens	117-122
2945762-3	1986	The homologous sequences are for the most part composed of repeated aa, the most remarkable of which is a Gly-X-His-Y-His motif where X and Y are small, uncharged aa, found six times in the T4 protein and seven times in the lambda ORF314 sequence.	Histidine	112-115	tail fiber protein	Escherichia virus Lambda	231-237
16212555-2	2006	TrZnT-1 (T. rubripes ZnT-1) shares overall topology with other members of the ZnT-1 family of zinc transporters, with six TMs (transmembrane domains) including a large histidine-rich intracellular loop between TM IV and V and intracellular C- and N-termini.	Histidine	168-177	zinc transporter 1	Takifugu rubripes	0-7
3878728-10	1985	The resonances for the C2-H protons of His-67 and His-72, which exist in the C3a part of the human C3 molecule, were assigned.	Histidine	39-42	complement C3	Homo sapiens	77-80
3878728-10	1985	The resonances for the C2-H protons of His-67 and His-72, which exist in the C3a part of the human C3 molecule, were assigned.	Histidine	50-53	complement C3	Homo sapiens	77-80
9806833-5	1998	FKBP23 is a glycoprotein retained in the endoplasmic reticulum by its carboxyl-terminal tetrapeptide His-Asp-Glu-Leu, as demonstrated by immunostaining, retention, and deglycosylation assays.	Histidine	101-104	FK506 binding protein 7	Mus musculus	0-6
9812898-3	1998	A 1.8 A resolution crystal structure of free and inhibited human MetAP-2 shows a covalent bond formed between a reactive epoxide of fumagillin and histidine-231 in the active site of MetAP-2.	Histidine	147-156	methionyl aminopeptidase 2	Homo sapiens	65-72
16212555-2	2006	TrZnT-1 (T. rubripes ZnT-1) shares overall topology with other members of the ZnT-1 family of zinc transporters, with six TMs (transmembrane domains) including a large histidine-rich intracellular loop between TM IV and V and intracellular C- and N-termini.	Histidine	168-177	zinc transporter 1	Takifugu rubripes	2-7
9812898-3	1998	A 1.8 A resolution crystal structure of free and inhibited human MetAP-2 shows a covalent bond formed between a reactive epoxide of fumagillin and histidine-231 in the active site of MetAP-2.	Histidine	147-156	methionyl aminopeptidase 2	Homo sapiens	183-190
16212555-2	2006	TrZnT-1 (T. rubripes ZnT-1) shares overall topology with other members of the ZnT-1 family of zinc transporters, with six TMs (transmembrane domains) including a large histidine-rich intracellular loop between TM IV and V and intracellular C- and N-termini.	Histidine	168-177	zinc transporter 1	Takifugu rubripes	21-26
3161731-10	1985	The amino acid compositions of GP Ib beta and GP IX were similar but showed marked differences in the levels of glutamic acid, alanine, histidine and arginine.	Histidine	136-145	glycoprotein Ib platelet subunit beta	Homo sapiens	31-41
16251206-5	2006	We have found that the Escherichia coli nucleotide excision enzyme UvrABC nuclease is able to incise Cr(III)- and Cr(III)-histidine-modified plasmid DNA and the extent of incision is proportional to the amount of Cr(III)-DNA adducts in the plasmid.	Histidine	122-131	nuclease	Escherichia coli	74-82
4086472-3	1985	Wheat germ calmodulin lacked tryptophan and contained 1 mol each of histidine, tyrosine, cysteine, and N epsilon-trimethyllysine residues per mol of the protein.	Histidine	68-77	CaM5	Triticum aestivum	11-21
9924333-7	1998	Each proband had a homozygous G--&gt;A transition at codon 124, replacing Arg--&gt;His, of the keratoepithelin gene.	Histidine	83-86	transforming growth factor beta induced	Homo sapiens	95-110
16508238-10	2006	A Hitrap-mouse recombinant His-tag-saposin A antibody column bound NPF, pulled down the NPF activity in TCGF, and the antibody recognized a 16kDa molecule in western-blotting of TCGF.	Histidine	27-30	interleukin 2	Mus musculus	104-108
3158613-4	1985	This result is the first description of a histidine replacing glutamine in the 61st position and provides further evidence that the 61st amino acid is one of the preferential sites for N-ras activation.	Histidine	42-51	NRAS proto-oncogene, GTPase	Homo sapiens	185-190
9756920-7	1998	In contrast to ACAT1 and similar to liver esterification, the activity of ARGP2 was relatively resistant to a histidine active site modifier.	Histidine	110-119	sterol O-acyltransferase 2	Homo sapiens	74-79
16508238-10	2006	A Hitrap-mouse recombinant His-tag-saposin A antibody column bound NPF, pulled down the NPF activity in TCGF, and the antibody recognized a 16kDa molecule in western-blotting of TCGF.	Histidine	27-30	interleukin 2	Mus musculus	178-182
16475832-5	2006	In this study, we have developed a two-step purification protocol using stably overexpressed His-tagged Cdr1p in Saccharomyces cerevisiae.	Histidine	93-96	cerebellar degeneration related protein 1	Homo sapiens	104-109
9753294-3	1998	The DQB1 homolog in NOD mice, I-Ab(g7), encodes a histidine at codon 56 and a serine at codon 57, while all other known I-Ab alleles encode proline and aspartic acid, respectively, at these positions.	Histidine	50-59	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	4-8
2581330-3	1985	Three of the antibodies directly inhibited the amidolytic activity of t-PA and the two most effective also bound near the active site histidine residue as determined by competition experiments using active site blocking agents.	Histidine	134-143	chromosome 20 open reading frame 181	Homo sapiens	70-74
16475834-10	2006	In contrast, isotope effects for association of UCH-L1 with transition-state analogue ubiquitin aldehyde suggest that an alternative mechanistic pathway can sometimes be available to UCH-L1 involving general base-catalyzed attack of Cys-SH by His-Im.	Histidine	243-246	ubiquitin C-terminal hydrolase L1	Homo sapiens	48-54
16475834-10	2006	In contrast, isotope effects for association of UCH-L1 with transition-state analogue ubiquitin aldehyde suggest that an alternative mechanistic pathway can sometimes be available to UCH-L1 involving general base-catalyzed attack of Cys-SH by His-Im.	Histidine	243-246	ubiquitin C-terminal hydrolase L1	Homo sapiens	183-189
9722655-3	1998	Monoclonal antibodies against the histidine-rich D5 domain in the light chain of 2-chain HK abolished the inhibitory effect of 2-chain HK on spreading of MG-63 osteosarcoma cells on vitronectin-coated tissue-culture plastic.	Histidine	34-43	vitronectin	Homo sapiens	182-193
16388603-5	2006	This conserved histidine (His-135 in HST2) activates the ribose 2"-hydroxyl for attack on the alpha-1"-O-alkylamidate.	Histidine	15-24	fibroblast growth factor 6	Homo sapiens	37-41
9722655-10	1998	The histidine-rich D5 domain of light chain of HK was identified as one of the binding sites of vitronectin, suggesting that the masking of the RGD cell-binding site of immobilized vitronectin is the molecular mechanism of anti-cell-spreading effect of HKa.	Histidine	4-13	vitronectin	Homo sapiens	96-107
9722655-10	1998	The histidine-rich D5 domain of light chain of HK was identified as one of the binding sites of vitronectin, suggesting that the masking of the RGD cell-binding site of immobilized vitronectin is the molecular mechanism of anti-cell-spreading effect of HKa.	Histidine	4-13	vitronectin	Homo sapiens	181-192
9687495-6	1998	A single non-conserved histidine residue (His193) in the large second extracellular loop (ECL2) of hDAT was discovered to be responsible for this difference.	Histidine	23-32	solute carrier family 6 member 3	Homo sapiens	99-103
6096811-4	1984	An A----T transversion at codon 61 results in the incorporation of histidine instead of glutamine in the c-K-ras gene product.	Histidine	67-76	KRAS proto-oncogene, GTPase	Homo sapiens	105-112
6432048-6	1984	The mechanism of interaction between chloride and the enzyme is discussed, and a model is proposed in which chloride interferes the tyrosinase activity by displacing a catalytically important ligand, probably a histidine residue of the side-chain, from the copper at the enzyme-active site.	Histidine	211-220	tyrosinase	Homo sapiens	132-142
16388603-5	2006	This conserved histidine (His-135 in HST2) activates the ribose 2"-hydroxyl for attack on the alpha-1"-O-alkylamidate.	Histidine	26-29	fibroblast growth factor 6	Homo sapiens	37-41
16842121-4	2006	In the cells over-expressing caspase-3, Western blotting with an anti-His-tag antibody confirmed the presence of caspase-3 in the three bands that were proposed to correspond to the precursor form (33 kDa), the mature forms processed at the prodomain alone (29 kDa, large subunit) and small sub unit (13 kD).	Histidine	70-73	caspase 3, apoptosis-related cysteine peptidase a	Danio rerio	29-38
6202883-2	1984	DNA sequence analysis of the glycoprotein D gene of the isolate revealed a single nucleotide alteration which changed the codon for asparagine to one encoding histidine at amino acid 97 in the protein.	Histidine	159-168	atypical chemokine receptor 1 (Duffy blood group)	Homo sapiens	29-43
9749675-7	1998	In addition, when His-90 in IIA(Glc) was replaced by glutamine, both phosphorylation of IIA(Glc) and the overproduction of cAMP in crp cells were eliminated.	Histidine	18-21	catabolite gene activator protein	Escherichia coli	131-134
16842121-4	2006	In the cells over-expressing caspase-3, Western blotting with an anti-His-tag antibody confirmed the presence of caspase-3 in the three bands that were proposed to correspond to the precursor form (33 kDa), the mature forms processed at the prodomain alone (29 kDa, large subunit) and small sub unit (13 kD).	Histidine	70-73	caspase 3, apoptosis-related cysteine peptidase a	Danio rerio	113-122
16186124-4	2005	Like other 2OG oxygenases, PAHX possesses a double-stranded beta-helix core, which supports three iron binding ligands (His(175), Asp(177), and His(264)); the 2-oxoacid group of 2OG binds to the Fe(II) in a bidentate manner.	Histidine	120-123	phytanoyl-CoA 2-hydroxylase	Homo sapiens	27-31
9677386-3	1998	Sequencing of the cDNA coding for this protein revealed that it is the chicken homologue of formiminotransferase cyclodeaminase (FTCD), a liver-specific enzyme involved in the histidine degradation pathway.	Histidine	176-185	formimidoyltransferase cyclodeaminase	Gallus gallus	92-127
9677386-3	1998	Sequencing of the cDNA coding for this protein revealed that it is the chicken homologue of formiminotransferase cyclodeaminase (FTCD), a liver-specific enzyme involved in the histidine degradation pathway.	Histidine	176-185	formimidoyltransferase cyclodeaminase	Gallus gallus	129-133
9688537-1	1998	Mutating the histidine at position 55 present at the subunit interface of the tetrameric E. coli single stranded DNA binding (SSB) protein to tyrosine or lysine leads to cells which are UV- and temperature-sensitive.	Histidine	13-22	single-stranded DNA-binding protein	Escherichia coli	126-129
6373642-2	1984	Human [10-asparagine-B] insulin ([ Asn10 -B] insulin), an analogue which differs from the parent molecule in that the histidine residue at position 10 of the B chain (B10) is replaced by asparagine, has been synthesized and isolated in purified form.	Histidine	118-127	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	167-170
6373642-5	1984	We have previously shown that the replacement of histidine at position B10 by lysine resulted in an analogue displaying ca.	Histidine	49-58	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	71-74
6320014-3	1984	Tonin can produce directly the vasoactive peptide angiotensin II, from angiotensin I, angiotensinogen and the synthetic tetradecapeptide substrate of renin by cleavage of a Phe-His bond.	Histidine	177-180	kallikrein 1-related peptidase C2	Rattus norvegicus	0-5
16186124-4	2005	Like other 2OG oxygenases, PAHX possesses a double-stranded beta-helix core, which supports three iron binding ligands (His(175), Asp(177), and His(264)); the 2-oxoacid group of 2OG binds to the Fe(II) in a bidentate manner.	Histidine	144-147	phytanoyl-CoA 2-hydroxylase	Homo sapiens	27-31
16186124-5	2005	The manner in which PAHX binds to Fe(II) and 2OG together with the presence of a cysteine residue (Cys(191)) 6.7 A from the Fe(II) and two further histidine residues (His(155) and His(281)) at its active site distinguishes it from that of the other human 2OG oxygenase for which structures are available, factor inhibiting hypoxia-inducible factor.	Histidine	167-170	phytanoyl-CoA 2-hydroxylase	Homo sapiens	20-24
6687316-1	1983	In this report we describe experiments showing that diethylpyrocarbonate, a histidine selective reagent, inhibits progestin binding to the chick oviduct progesterone receptor.	Histidine	76-85	progesterone receptor	Gallus gallus	153-174
6687316-2	1983	Because this inhibition is reversed by hydroxylamine, we suggest that the chick oviduct progesterone receptor contains one or more histidine residues that regulate progestin binding.	Histidine	131-140	progesterone receptor	Gallus gallus	88-109
16186124-5	2005	The manner in which PAHX binds to Fe(II) and 2OG together with the presence of a cysteine residue (Cys(191)) 6.7 A from the Fe(II) and two further histidine residues (His(155) and His(281)) at its active site distinguishes it from that of the other human 2OG oxygenase for which structures are available, factor inhibiting hypoxia-inducible factor.	Histidine	180-183	phytanoyl-CoA 2-hydroxylase	Homo sapiens	20-24
9630626-6	1998	Comparison of isoacidic and isosteric inhibitors reveals that (i) the hydrogen bond of the amide proton to His-48 is crucial for strong PLA2 inhibition, (ii) regardless of the headgroup unsubstituted N-acyl groups result in optimal amide acidity for PLA2 inhibition and (iii) the exceptionally strong inhibition by acetamides and the isosteric fluoroacetamides is due to an additional steric effect.	Histidine	107-110	phospholipase A2 group IIA	Homo sapiens	136-140
16186124-6	2005	Of the 15 PAHX residues observed to be mutated in RD patients, 11 cluster in two distinct groups around the Fe(II) (Pro(173), His(175), Gln(176), Asp(177), and His(220)) and 2OG binding sites (Trp(193), Glu(197), Ile(199), Gly(204), Asn(269), and Arg(275)).	Histidine	126-129	phytanoyl-CoA 2-hydroxylase	Homo sapiens	10-14
9630626-6	1998	Comparison of isoacidic and isosteric inhibitors reveals that (i) the hydrogen bond of the amide proton to His-48 is crucial for strong PLA2 inhibition, (ii) regardless of the headgroup unsubstituted N-acyl groups result in optimal amide acidity for PLA2 inhibition and (iii) the exceptionally strong inhibition by acetamides and the isosteric fluoroacetamides is due to an additional steric effect.	Histidine	107-110	phospholipase A2 group IIA	Homo sapiens	250-254
16186124-6	2005	Of the 15 PAHX residues observed to be mutated in RD patients, 11 cluster in two distinct groups around the Fe(II) (Pro(173), His(175), Gln(176), Asp(177), and His(220)) and 2OG binding sites (Trp(193), Glu(197), Ile(199), Gly(204), Asn(269), and Arg(275)).	Histidine	160-163	phytanoyl-CoA 2-hydroxylase	Homo sapiens	10-14
6864333-11	1983	The presence of an intact protein (bovine serum albumin) sharply decreased the ileal absorption of the L-histidine:zinc complex.	Histidine	103-114	albumin	Rattus norvegicus	42-55
9647635-4	1998	Each gene encodes a complete ORF with no less than 86% amino acid sequence identity to human RNase k6 with the eight cysteines and catalytic histidines (H15 and H123) and lysine (K38) typically observed among members of the RNase A superfamily.	Histidine	141-151	ribonuclease A family member k6	Homo sapiens	93-101
15927448-4	2005	We previously observed that bacterially expressed his-p68 was phosphorylated at multiple sites including serine/threonine and tyrosine [L. Yang, Z.R.	Histidine	50-53	DEAD-box helicase 5	Homo sapiens	54-57
9592734-3	1998	The recombinant E2 protein contained an aminoterminal tag of six histidines that could be used for purification by the nickel chelate affinity chromatography.	Histidine	65-75	ubiquitin conjugating enzyme E2 B	Homo sapiens	16-26
16338409-1	2005	The structure of A. thaliana imidazoleglycerol-phosphate dehydratase, an enzyme of histidine biosynthesis and a target for the triazole phosphonate herbicides, has been determined to 3.0 A resolution.	Histidine	83-92	imidazoleglycerol-phosphate dehydratase	Arabidopsis thaliana	29-68
9521736-0	1998	Localization of histidine residues responsible for heme axial ligation in cytochrome b556 of complex II (succinate:ubiquinone oxidoreductase) in Escherichia coli.	Histidine	16-25	oxidoreductase	Escherichia coli	126-140
7138844-7	1982	These binding constants and the predicted response of the active-site histidine pK1/2 values to anion binding are shown to agree with experimental determinations.	Histidine	70-79	prokineticin 1	Homo sapiens	80-85
6289876-1	1982	The titration curves of the C-2 histidine protons of RNase A and of derivative II--a covalent derivative obtained by reaction of the enzyme with the halogenated nucleotide 9-beta-D-ribofuranosyl-6-chloropurine 5"-phosphate--in the presence of a number of purine nucleosides, nucleoside monophosphates, and nucleoside diphosphates were studied by means of proton nuclear magnetic resonance at 270 MHz.	Histidine	32-41	complement C2	Bos taurus	28-31
9488672-3	1998	Unlike other proteins that interact with heparin via lysine or arginine residues, HPRG relies exclusively on histidine residues for this interaction.	Histidine	109-118	histidine rich glycoprotein	Homo sapiens	82-86
16196090-6	2005	The His(6)-RB/GST-E7 interaction was challenged by spotting the His(6)-RB solution in the presence of a RB binding peptide (PepC) derived from a motif on E7.	Histidine	4-7	peptidase C	Homo sapiens	124-128
9488672-11	1998	This provides a mechanism to regulate the function of HPRG (the local pH) and rationalizes the role of its unique, conserved histidine-proline-rich domain.	Histidine	125-134	histidine rich glycoprotein	Homo sapiens	54-58
9482873-4	1998	Comparison of the GliPR model with the P14a structure lead to the identification of a common partially solvent-exposed spatial cluster of four amino acid residues, His-69, Glu-88, Glu-110, and His-127 in the GliPR numeration.	Histidine	164-167	GLI pathogenesis related 1	Homo sapiens	18-23
9482873-4	1998	Comparison of the GliPR model with the P14a structure lead to the identification of a common partially solvent-exposed spatial cluster of four amino acid residues, His-69, Glu-88, Glu-110, and His-127 in the GliPR numeration.	Histidine	164-167	GLI pathogenesis related 1	Homo sapiens	208-213
9482873-4	1998	Comparison of the GliPR model with the P14a structure lead to the identification of a common partially solvent-exposed spatial cluster of four amino acid residues, His-69, Glu-88, Glu-110, and His-127 in the GliPR numeration.	Histidine	193-196	GLI pathogenesis related 1	Homo sapiens	18-23
9482873-4	1998	Comparison of the GliPR model with the P14a structure lead to the identification of a common partially solvent-exposed spatial cluster of four amino acid residues, His-69, Glu-88, Glu-110, and His-127 in the GliPR numeration.	Histidine	193-196	GLI pathogenesis related 1	Homo sapiens	208-213
7334672-0	1981	[Measurement of histidase activity in the oral mucous membrane with radioactivity labelled L-histidine (author"s transl)].	Histidine	91-102	histidine ammonia-lyase	Homo sapiens	16-25
16102717-3	2005	It also allowed us to accurately determine the kinetic rate constants for the interaction between His-CypA and CsA.	Histidine	98-101	peptidylprolyl isomerase A	Homo sapiens	102-106
6921142-5	1981	The results indicate that TosLysCH2Cl inactivates kallikrein activity and support the notion that reactive histidine residue(s) participates in the active center of Kallikrein for catalysis.	Histidine	107-116	kallikrein related peptidase 4	Homo sapiens	165-175
9442066-14	1998	273, 2241-2248) and similar data for wild-type and mutant peroxidases of plant and fungal origin suggests (i) a proton-induced conformational change from an inactive BP 1 at neutral pH to a low activity BP 1 form with a functional distal histidine and (ii) a Ca(2+)-induced slow conformational change (at least compared with compound I formation) of this low activity form to a high activity BP 1 with a typical peroxidase reactivity.	Histidine	238-247	prx7	Hordeum vulgare	58-68
9442067-6	1998	The key differences between the structures of active horseradish peroxidase C and inactive BP 1 include the orientation of the catalytic distal histidine, disruption of a hydrogen bond between this histidine and a conserved asparagine, and apparent substitution of calcium at the distal cation binding site with sodium at pH 7.5.	Histidine	144-153	prx7	Hordeum vulgare	65-75
9442067-6	1998	The key differences between the structures of active horseradish peroxidase C and inactive BP 1 include the orientation of the catalytic distal histidine, disruption of a hydrogen bond between this histidine and a conserved asparagine, and apparent substitution of calcium at the distal cation binding site with sodium at pH 7.5.	Histidine	198-207	prx7	Hordeum vulgare	65-75
7239137-2	1981	It shares a common C-terminal decapeptide homology with bombesin (except for a His/Gln interchange at residue 8 from C-terminus).	Histidine	79-82	gastrin releasing peptide	Homo sapiens	56-64
16102717-4	2005	His-CypA was first captured on a Ni2+-nitrilotriacetic acid (NTA) sensor chip and was then briefly covalently stabilized, coupling via primary amines.	Histidine	0-3	peptidylprolyl isomerase A	Homo sapiens	4-8
16183033-7	2005	The IC50 for proton effects was close to the pKa for histidine, suggesting conserved histidine residues present in SLC39A1 play a critical role in Zn2+ influx and are involved in the pH effect.	Histidine	53-62	solute carrier family 39 member 1	Homo sapiens	115-122
7211776-1	1981	A highly specific and sensitive procedure for determining histidase activity, with labeled histidine as the substrate, that requires only 1 to 2 mg of stratum corneum epidermidis has been developed.	Histidine	91-100	histidine ammonia-lyase	Homo sapiens	58-67
7213621-7	1981	the catalytic role of glyoxalase II appears to involve direct nucleophilic attack of the thiol ester by an active-site histidine residue, based upon inactivation experiments using diethyl pyrocarbonate and photoinactivation with methylene blue.	Histidine	119-128	hydroxyacyl glutathione hydrolase	Rattus norvegicus	22-35
10100329-5	1998	Variation is also found in the channel lining M2 regions, including the replacement in four subunits of the highly conserved leucine at the 9" position by valine and most notably, the replacement in all ACR-8-like subunits of the highly conserved glutamic acid at the -1" position by histidine.	Histidine	284-293	AcetylCholine Receptor	Caenorhabditis elegans	203-208
10100329-7	1998	The calculated electrostatic potential energy profile for the M2 region of ACR-8 differs strikingly from that of ACR-16[Ce21] largely due to the presence of histidine at the -1" position, suggesting a possible perturbation of nAChR channel action permeability in the presence of this subunit type.	Histidine	157-166	AcetylCholine Receptor	Caenorhabditis elegans	75-80
9389442-5	1997	A single amino acid difference, either arginine (R) or histidine (H) at amino acid position 131, underlies differential interaction with mIgG1.	Histidine	55-64	LOC105243590	Mus musculus	137-142
16183033-7	2005	The IC50 for proton effects was close to the pKa for histidine, suggesting conserved histidine residues present in SLC39A1 play a critical role in Zn2+ influx and are involved in the pH effect.	Histidine	85-94	solute carrier family 39 member 1	Homo sapiens	115-122
16109718-3	2005	Analysis of ATF3 mRNA turnover revealed that the half-life was increased from about 1 h in control cells to greater than 8 h in the histidine-deprived state, demonstrating mRNA stabilization in response to nutrient deprivation.	Histidine	132-141	activating transcription factor 3	Homo sapiens	12-16
9305893-13	1997	These results suggest that His-150 may be the base that abstracts the alpha-proton of the substrate, leading to formation of the quinonoid intermediate in the reaction catalyzed by SHMT.	Histidine	27-30	serine hydroxymethyltransferase, cytosolic	Ovis aries	181-185
6968751-3	1980	The porcine C3a octapeptide is 3 times more active than the common pentapeptide, but the human octapeptide (Ala(70)-Ser-His-Leu(73)-Gly-Leu(75)-Ala-Arg(77) is 12 times more active than the pentapeptide.	Histidine	120-123	complement C3	Homo sapiens	12-15
6968751-5	1980	Thus, the increased activity of the human C3a octapeptide over the pentapeptide appears to be related to the backbone of residues 70 to 72 and is not due to the presence of the hydroxyl group of serine-71, the imidazole ring of histidine-72, or a positive charge at or near the NH2 terminus.	Histidine	228-237	complement C3	Homo sapiens	42-45
9306693-3	1997	The HSF1 kinase forms a stable complex with AtHSF1, which can be detected by kinase pull-down assays using a histidine-tagged AtHSF1 substrate.	Histidine	109-118	heat shock factor 1	Arabidopsis thaliana	44-50
16109718-10	2005	In contrast, the interaction of AUF1 with the ATF3 mRNA is decreased in histidine-deprived cells relative to control cells.	Histidine	72-81	activating transcription factor 3	Homo sapiens	46-50
9306693-3	1997	The HSF1 kinase forms a stable complex with AtHSF1, which can be detected by kinase pull-down assays using a histidine-tagged AtHSF1 substrate.	Histidine	109-118	heat shock factor 1	Arabidopsis thaliana	126-132
16084833-15	2005	Consequently, single point mutants rTAXI-IIA[P294L] and rTAXI-IIB[Q376H], both displaying the Leu/His combination corresponding to TAXI-I, were able to inhibit ANX.	Histidine	98-101	chitinase CLP	Triticum aestivum	36-42
9256424-5	1997	Nm23-H1 also can transfer phosphate from its catalytic histidine to histidines on ATP-citrate lyase and succinic thiokinase.	Histidine	55-64	ATP citrate lyase	Homo sapiens	82-99
9256424-5	1997	Nm23-H1 also can transfer phosphate from its catalytic histidine to histidines on ATP-citrate lyase and succinic thiokinase.	Histidine	68-78	ATP citrate lyase	Homo sapiens	82-99
9166854-7	1997	In a Northern blot analysis from homogeneous tissue biopsy from the intradermal injection sites, RANTES was more potent than MCP-1 in increasing histidine decarboxylase (HDC) mRNA, the sole enzyme responsible for the production of histamine from histidine.	Histidine	145-154	C-C motif chemokine ligand 5	Rattus norvegicus	97-103
7373889-0	1980	[Measurement of histidase activity in the stratum corneum with radioactively labelled L-histidine (author"s transl)].	Histidine	86-97	histidine ammonia-lyase	Homo sapiens	16-25
518870-8	1979	There are two possible implications of this result: (1) the iron atom spin state is not the only major factor in the determination of its position with respect to the heme plane or (2) the change with conformation of the protein force exerted by the proximal histidine on the iron atom (for an iron to heme-plane displacement of less than 0.3 A) is less than 50% of that expected from simple models in which this motion is responsible for cooperativity.	Histidine	259-268	spindlin 1	Homo sapiens	70-74
16834223-5	2005	The most stable conformers and the enthalpies of neutral and protonated histidine and its methyl ester are calculated at the G3(MP2) level of theory.	Histidine	72-81	tryptase pseudogene 1	Homo sapiens	128-131
38849-0	1979	Affinity labeling of histidine and lysine residue in the adenosine deaminase substrate binding site.	Histidine	21-30	adenosine deaminase	Homo sapiens	57-76
36073-17	1979	We propose that the observed inhibition of pyruvate carboxylase by formiminoglutamate may account in part for the toxic effect of excess histidine.	Histidine	137-146	pyruvate carboxylase	Rattus norvegicus	43-63
9192170-3	1997	In this study, we report histidine-like immunoreactivity in the rat retina with the use of antibodies raised against histidine coupled to bovine serum albumin (BSA) with glutaraldehyde.	Histidine	25-34	albumin	Rattus norvegicus	145-158
9266477-1	1997	The structure of neuromedin C, a 10-residue bombesin-like neuropeptide with the sequence Gly-Asn-His-Trp-Ala-Val-Gly-His-Leu-Met-NH2, has been investigated.	Histidine	97-100	gastrin releasing peptide	Homo sapiens	17-29
9180275-1	1997	The Candida albicans CAN1 gene, encoding a high-affinity permease for arginine, lysine and histidine, was tagged at its C-terminus with a c-myc epitope and introduced into strains of Saccharomyces cerevisiae lacking basic amino acid permeases.	Histidine	91-100	arginine permease CAN1	Saccharomyces cerevisiae S288C	21-25
16834223-8	2005	Proton affinity (PA) of histidine calculated by the G3(MP2) method is 233.2 and 232.4 kcal mol(-1) for protonation at the imidazole ring and at the amino group nitrogens, respectively, which is about 3-5 kcal mol(-1) lower than the reported experimental value.	Histidine	24-33	tryptase pseudogene 1	Homo sapiens	55-58
15976002-4	2005	Histidine (His)-tagged soluble RAP (amino acids 39 to 356) lacking the amino-terminal signal peptide and the carboxy-terminal endoplasmic reticulum retention signal was prepared by bacterial expression (designated His-sRAP).	Histidine	0-9	steroid receptor RNA activator 1	Mus musculus	218-222
360048-6	1978	The use of diethyl pyrocarbonate indicates the participation also of histidine in fibrinogen-thrombin interactions and that, whereas the histidine residues of the Bbeta chain are involved to a great extent, it appears that those of the Aalpha chain are not.	Histidine	69-78	coagulation factor II, thrombin	Bos taurus	93-101
15976002-4	2005	Histidine (His)-tagged soluble RAP (amino acids 39 to 356) lacking the amino-terminal signal peptide and the carboxy-terminal endoplasmic reticulum retention signal was prepared by bacterial expression (designated His-sRAP).	Histidine	0-3	steroid receptor RNA activator 1	Mus musculus	218-222
9126358-2	1997	Histidine-tagged full-length hVDR was overexpressed in E.coli and purified to near homogeneity using Ni-NTA and gel filtration columns without denature/renature procedures.	Histidine	0-9	vitamin D receptor	Homo sapiens	29-33
15976002-5	2005	After the direct interaction between His-sRAP and megalin was confirmed, mice were given a single intraperitoneal administration of His-sRAP (3.5 mg/dose).	Histidine	37-40	steroid receptor RNA activator 1	Mus musculus	41-45
9119391-10	1997	The two polymorphic GPT isozymes are the results of a nucleotide substitution in codon 14, coding for a histidine in GPT-1 and an asparagine in GPT-2, which causes a gain or loss of an NlaIII restriction site.	Histidine	104-113	glutamic--pyruvic transaminase 2	Homo sapiens	144-149
15976002-5	2005	After the direct interaction between His-sRAP and megalin was confirmed, mice were given a single intraperitoneal administration of His-sRAP (3.5 mg/dose).	Histidine	132-135	steroid receptor RNA activator 1	Mus musculus	136-140
9091313-0	1997	Identification of essential aspartic acid and histidine residues of hormone-sensitive lipase: apparent residues of the catalytic triad.	Histidine	46-55	lipase E, hormone sensitive type	Homo sapiens	68-92
667106-4	1978	This observation was interpreted in terms of the stronger interaction between proximal histidine and ferric heme iron in methemoglobin than in metmyoglobin.	Histidine	87-96	hemoglobin subunit gamma 2	Homo sapiens	121-134
207308-2	1978	3-SLHis-105-RNase A is an active derivative of ribonuclease A (RNase A) spin-labeled at the 3 position of the imidazole ring of histidine-105.	Histidine	128-137	spindlin 1	Homo sapiens	72-76
207308-4	1978	The results of these experiments indicate that the spin-label attached to histidine-105 of RNase A is sensitive to modifications affecting the conformational integrity of the molecule and to the reconstituting effects of various active-center ligands.	Histidine	74-83	spindlin 1	Homo sapiens	51-55
9091313-1	1997	It is expected that hormone-sensitive lipase (HSL), like most other lipases and esterases, adopts an alpha/beta-hydrolase fold and has a catalytic triad of serine, aspartic or glutamic acid, and histidine.	Histidine	195-204	lipase E, hormone sensitive type	Homo sapiens	20-44
15976002-6	2005	Immunostaining and Western blot analyses demonstrated the uptake of His-sRAP and the accelerated internalization of megalin in proximal tubular cells 1 h after administration.	Histidine	68-71	steroid receptor RNA activator 1	Mus musculus	72-76
9091313-1	1997	It is expected that hormone-sensitive lipase (HSL), like most other lipases and esterases, adopts an alpha/beta-hydrolase fold and has a catalytic triad of serine, aspartic or glutamic acid, and histidine.	Histidine	195-204	lipase E, hormone sensitive type	Homo sapiens	46-49
9091313-2	1997	Recently, we have published a three-dimensional model for the C-terminal catalytic domain of HSL, having an alpha/beta-hydrolase fold and with Ser-423(1), Asp-703 and His-733 in the catalytic triad (Contreras et al.	Histidine	167-170	lipase E, hormone sensitive type	Homo sapiens	93-96
15976002-11	2005	The results suggest that the His-sRAP-induced acceleration of megalin-mediated endocytosis caused phosphaturia via altered subcellular distribution of NaPi-II.	Histidine	29-32	steroid receptor RNA activator 1	Mus musculus	33-37
15976002-11	2005	The results suggest that the His-sRAP-induced acceleration of megalin-mediated endocytosis caused phosphaturia via altered subcellular distribution of NaPi-II.	Histidine	29-32	low density lipoprotein receptor-related protein 2	Mus musculus	62-69
15930519-7	2005	Site-directed mutagenesis was used to support proposals for the identity of the iron binding ligands (His-175, Asp-177, His-264) of the 2-His-1-carboxylate motif of PAHX.	Histidine	102-105	phytanoyl-CoA 2-hydroxylase	Homo sapiens	165-169
9533030-5	1997	Histidine residues, which are possible heme axial ligands in cytochrome b of complex II, were found in the second transmembrane segment of each subunit.	Histidine	0-9	mitochondrially encoded cytochrome b	Homo sapiens	61-73
921767-1	1977	The C-2 proton of one histidine residue in bovine erythrocyte superoxide dismutase is shown to be particularly labile.	Histidine	22-31	complement C2	Bos taurus	4-7
15930519-7	2005	Site-directed mutagenesis was used to support proposals for the identity of the iron binding ligands (His-175, Asp-177, His-264) of the 2-His-1-carboxylate motif of PAHX.	Histidine	120-123	phytanoyl-CoA 2-hydroxylase	Homo sapiens	165-169
405036-0	1977	Histidine-200 alters inhibitor binding in human carbonic anhydrase B.	Histidine	0-9	carbonic anhydrase 2	Homo sapiens	48-68
9392828-4	1997	We report that intact rat pro CCK was produced with an amino-terminal His-Tag in e. coli, and it was secreted from sf9 and other insect cells infected with a recombinant baculovirus vector.	Histidine	70-73	cholecystokinin	Rattus norvegicus	30-33
16004422-6	2005	Oriented coupling of the Fab fragments on chelate-epoxy cellulose via a C-terminal histidine tag, however, increased the adsorption capacity to 178.3 +/- 8.6 pg TNF/mg adsorbent wet weight.	Histidine	83-92	FA complementation group B	Homo sapiens	25-28
9606726-5	1997	A histidine at position 260 in the melanocortin-4 receptor is important for normal receptor function.	Histidine	2-11	melanocortin 4 receptor	Rattus norvegicus	35-58
15817478-2	2005	Dopamine inhibition of alpha-syn fibrillization generated exclusively spherical oligomers that depended on dopamine autoxidation but not alpha-syn oxidation, because mutagenesis of Met, His, and Tyr residues in alpha-syn did not abrogate this inhibition.	Histidine	186-189	synuclein alpha	Homo sapiens	23-32
8973195-1	1996	The five cysteines closest to the carboxyl terminus of human ferrochelatase have been individually mutated to serine, histidine, or aspartate residues in an attempt to identify the protein ligands to the [2Fe-2S] cluster.	Histidine	118-127	ferrochelatase	Homo sapiens	61-75
8962082-10	1996	In addition, a human FAS cDNA encoding domains II and III (enoyl and beta-ketoacyl reductases, acyl carrier protein, and thioesterase) was cloned in pET-32b(+) and expressed in E. coli as a fusion protein with thioredoxin and six in-frame histidine residues.	Histidine	239-248	fatty acid synthase	Homo sapiens	21-24
8986225-6	1996	Three different mutations were found in the exon 3 sequence of CCKBR: His (CAT) at aa207--&gt;His (CAC) (5.4%), Arg (CGC) at aa215--&gt;His (CAC) (4.5%), and Val (GTG) at aa138--&gt;Met (ATG) (0.9%) in controls.	Histidine	70-73	carbonic anhydrase 2	Homo sapiens	99-102
833672-11	1977	Offspring from gilts fed the histidine-free diet had lower blood hemoglobin concentrations than their counterparts from gilts receiving histidine.	Histidine	29-38	HGB	Sus scrofa	65-75
993333-3	1976	Glutamine B10 and histidine E7 (the distal histidine) swing towards each other and, between them, stabilize a water molecule in the normally hydrophobic heme pocket.	Histidine	43-52	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	10-13
15889294-8	2005	The AtPTR3 gene was induced by the amino acids histidine, leucine and phenylalanine in cotyledons and lower leaves, whereas a strong induction was obtained in the whole plant upon exposure to salt.	Histidine	47-56	peptide transporter 3	Arabidopsis thaliana	4-10
8090-0	1976	pH dependence of tritium exchange with the C-2 protons of the histidines in bovine trypsin.	Histidine	62-72	complement C2	Bos taurus	43-46
8090-1	1976	At pH 8.9 and 37 degrees C the half-times for tritium exchange with the C-2 protons of the histidines of trypsin are 73 days for His-57, and greater than 1000 days for His-40 and His-91.	Histidine	91-101	complement C2	Bos taurus	72-75
8090-1	1976	At pH 8.9 and 37 degrees C the half-times for tritium exchange with the C-2 protons of the histidines of trypsin are 73 days for His-57, and greater than 1000 days for His-40 and His-91.	Histidine	129-132	complement C2	Bos taurus	72-75
8090-1	1976	At pH 8.9 and 37 degrees C the half-times for tritium exchange with the C-2 protons of the histidines of trypsin are 73 days for His-57, and greater than 1000 days for His-40 and His-91.	Histidine	168-171	complement C2	Bos taurus	72-75
8090-1	1976	At pH 8.9 and 37 degrees C the half-times for tritium exchange with the C-2 protons of the histidines of trypsin are 73 days for His-57, and greater than 1000 days for His-40 and His-91.	Histidine	168-171	complement C2	Bos taurus	72-75
8910277-3	1996	One mutant of activated human RAC protein, RACV12H40 (with valine and histidine substituted at position 12 and 40, respectively), was defective in binding to PAK3, a Ste20-related p21-activated kinase (PAK), but bound to POR1, a RAC-binding protein.	Histidine	70-79	p21 (RAC1) activated kinase 3	Homo sapiens	158-162
8936589-5	1996	To aid purification, the protein was expressed with an amino-terminal extension encoding an initiating methionine and 10 histidine residues followed by an enterokinase cleavage site; 0.3mg of HIS-SRP 54-kDa was purified to give a single band on SDS-PAGE in 20% yield from 500 ml of cultured E. coli.	Histidine	192-195	signal recognition particle 54	Canis lupus familiaris	196-202
8863827-6	1996	Induction of a pheromone-responsive FUS1-HIS3 reporter gene in far1 his3 cells permits cell growth in medium lacking histidine.	Histidine	117-126	imidazoleglycerol-phosphate dehydratase HIS3	Saccharomyces cerevisiae S288C	41-45
8863827-6	1996	Induction of a pheromone-responsive FUS1-HIS3 reporter gene in far1 his3 cells permits cell growth in medium lacking histidine.	Histidine	117-126	cyclin-dependent protein serine/threonine kinase inhibiting protein FAR1	Saccharomyces cerevisiae S288C	63-67
8863827-6	1996	Induction of a pheromone-responsive FUS1-HIS3 reporter gene in far1 his3 cells permits cell growth in medium lacking histidine.	Histidine	117-126	imidazoleglycerol-phosphate dehydratase HIS3	Saccharomyces cerevisiae S288C	68-72
8090-2	1976	These half-times are much longer than the half-life of exchange for the C-2 proton of free histidine (2.8 days at pD 8.2), and longer than any previously reported half-time of exchange at pH greater than 8.	Histidine	91-100	complement C2	Bos taurus	72-75
15792953-4	2005	Recombinant GcpE protein was purified by an N-terminal His(6) tag and reconstituted as a [4Fe-4S](2+) metalloprotein.	Histidine	55-58	ispG	Thermosynechococcus elongatus BP-1	12-16
8831696-4	1996	We show that two histidines and a glutamic acid in the H-E-X-G-H motif and a glutamic acid 25 residues from the second histidine are essential for MIP function in vivo.	Histidine	17-27	mitochondrial intermediate peptidase	Homo sapiens	147-150
8831696-4	1996	We show that two histidines and a glutamic acid in the H-E-X-G-H motif and a glutamic acid 25 residues from the second histidine are essential for MIP function in vivo.	Histidine	17-26	mitochondrial intermediate peptidase	Homo sapiens	147-150
15892892-5	2005	Trz1p has two putative nucleotide triphosphate-binding motifs (P-loop) and a conserved histidine motif.	Histidine	87-96	tRNase Z	Saccharomyces cerevisiae S288C	0-5
8836129-0	1996	Histidine residues in rabbit liver microsomal cytochrome P-450 2B4 control electron transfer from NADPH-cytochrome P-450 reductase and cytochrome b5.	Histidine	0-9	NADPH--cytochrome P450 reductase	Oryctolagus cuniculus	98-130
8836129-0	1996	Histidine residues in rabbit liver microsomal cytochrome P-450 2B4 control electron transfer from NADPH-cytochrome P-450 reductase and cytochrome b5.	Histidine	0-9	cytochrome b5	Oryctolagus cuniculus	135-148
8836175-2	1996	The open reading frame of RNase k6, amplified from human genomic DNA, encodes a 150 amino acid polypeptide with eight cysteines and histidine and lysine residues corresponding to those found in the active site of the prototype, ribonuclease A.	Histidine	132-141	ribonuclease A family member k6	Homo sapiens	26-34
1033-0	1975	LYSYL oxidase dependent synthesis of a collagen cross-link containing histidine.	Histidine	70-79	lysyl oxidase	Homo sapiens	0-13
511-0	1975	A study of the histidine residues of human carbonic anhydrase C using 270 MHz proton magnetic resonance.	Histidine	15-24	carbonic anhydrase 2	Homo sapiens	43-63
15892892-6	2005	The histidine motif and the putative nucleotide binding motif at the C-domain are important for Trz1p function because mutant proteins bearing changes to the critical residues in these motifs are unable to rescue deletion of TRZ1.	Histidine	4-13	tRNase Z	Saccharomyces cerevisiae S288C	96-101
15977068-4	2005	As a result, DEAD (Asp-Glu-Ala-Asp/His) box polypeptide 47 (DDX 47), recently identified as RNA helicase, is identified as a binding partner of GABARAP.	Histidine	35-38	DEAD-box helicase 47	Homo sapiens	60-66
1014-0	1975	Evidence for histidine as another functional group of delta-aminolevulinic acid dehydratase from beef liver.	Histidine	13-22	aminolevulinate dehydratase	Homo sapiens	54-91
8886274-2	1996	An intrinsic fluorescence study showed that the tryptophan residues at position 13 and 85 within CRP were located in an internal, nonpolar environment, and the conformational change induced by the binding of cAMP occurred around the tryptophan residue NMR experiment has manifested that the comformational change around the tryptophan residue at position 85 and histidine residue at position 159 of CRP is induced by the binding of cAMP.	Histidine	362-371	catabolite gene activator protein	Escherichia coli	97-100
8886274-2	1996	An intrinsic fluorescence study showed that the tryptophan residues at position 13 and 85 within CRP were located in an internal, nonpolar environment, and the conformational change induced by the binding of cAMP occurred around the tryptophan residue NMR experiment has manifested that the comformational change around the tryptophan residue at position 85 and histidine residue at position 159 of CRP is induced by the binding of cAMP.	Histidine	362-371	catabolite gene activator protein	Escherichia coli	399-402
15977068-4	2005	As a result, DEAD (Asp-Glu-Ala-Asp/His) box polypeptide 47 (DDX 47), recently identified as RNA helicase, is identified as a binding partner of GABARAP.	Histidine	35-38	GABA type A receptor-associated protein	Homo sapiens	144-151
15849306-4	2005	The predicted GL1 protein includes three histidine-rich domains, the landmark of a family of membrane-bound desaturases/hydroxylases, including fatty acid-modifying enzymes.	Histidine	41-50	glossy 1	Zea mays	14-17
8703082-5	1996	The mammalian Scip gene had alanine, glycine, proline, and histidine repeats, but the nonmammalian homologue completely lacked these repeats.	Histidine	59-68	POU class 3 homeobox 1	Homo sapiens	14-18
1150653-2	1975	The alpha,beta eliminations of NH3 from L-histidine and 4-fluoro-L-histidine by histidine ammonia-lyase appear to occur by similar mechanisms, although a large difference in Vmax for the two reactions was observed.	Histidine	40-51	histidine ammonia-lyase	Homo sapiens	80-103
15900706-8	2005	A recombinant, C-terminally His-tagged synaptobrevin fragment bound to nickel beads specifically bound synaptophysin, syntaxin and SNAP25 from vesicular detergent extracts.	Histidine	28-31	synaptosome associated protein 25	Homo sapiens	131-137
239193-2	1975	For neurophysin I alone, a normal titration curve for the C-2 proton resonance of the lone histidine residue was obtained with an apparent ionization constant of 6.9 addition of oxytocin to a solution of neurophysin I at pH 6.5 resulted in several changes in the spectrum.	Histidine	91-100	complement C2	Bos taurus	58-61
8844843-10	1996	The effects of the His 92 Gln and Phe 100 Ala mutations on GpC turnover are additive in the corresponding double mutant, indicating that the contribution of Phe 100 to catalysis is independent of the catalytic acid His 92.	Histidine	19-22	glycophorin C (Gerbich blood group)	Homo sapiens	59-62
15829403-5	2005	The B13 S15.4 peptide-specific CD4+ T-cell clone 3E5 was tested in proliferation assays against 15 Lys/His-substituted S15.4-derived peptides for TCR/HLA contact analysis.	Histidine	103-106	NADH:ubiquinone oxidoreductase subunit A5	Homo sapiens	4-7
8675572-2	1996	We expressed in Chinese hamster ovary cells the human TSHR ectodomain (ECD) with a carboxyl-terminus six-histidine tag.	Histidine	105-114	thyroid stimulating hormone receptor	Homo sapiens	54-58
5097573-9	1971	In elastin from plaque intima, the following polar amino acids were increased significantly: aspartic acid, threonine, serine, glutamic acid, lysine, histidine, and arginine; whereas, cross-linking amino acids: desmosine, isodesmosine, and lysinonorleucine were decreased significantly.	Histidine	150-159	elastin	Homo sapiens	3-10
15611058-4	2005	Here, we have detergent-solubilized, purified, and reconstituted enzymatically active His-tagged Ste14p from S. cerevisiae, thus providing conclusive proof that Ste14p is the sole component necessary for the carboxylmethylation of isoprenylated substrates.	Histidine	86-89	protein-S-isoprenylcysteine carboxyl O-methyltransferase	Saccharomyces cerevisiae S288C	97-103
5492291-0	1970	Amino acid substitution (histidine to tyrosine) in a glucose-6-phosphate dehydrogenase variant (G6PD Hektoen) associated with over-production.	Histidine	25-34	glucose-6-phosphate dehydrogenase	Homo sapiens	53-86
5492291-0	1970	Amino acid substitution (histidine to tyrosine) in a glucose-6-phosphate dehydrogenase variant (G6PD Hektoen) associated with over-production.	Histidine	25-34	glucose-6-phosphate dehydrogenase	Homo sapiens	96-100
5778664-0	1969	Evidence for a specific function for histidine residues in transaldolase.	Histidine	37-46	transaldolase 1	Homo sapiens	59-72
8822581-7	1996	The triplet GAT, coding for the amino acid residue gamma 364, was replaced by CAT, resulting in the substitution of Asp-->His.	Histidine	122-125	glycine-N-acyltransferase	Homo sapiens	12-15
8639599-3	1996	Holocytochrome b5, the protein with iron protoporphyrin-IX liganded to His-39 and His-63, contains in sequence the following elements of secondary structure: beta 1-alpha 1-beta 4-beta 3-alpha 2-alpha 3-beta 5-alpha 4-alpha 5-beta 2-alpha 6 [Mathews, F.S., Czerwinski, E. W., &amp; Argos, P. (1979) The Porphyrins, Vol.	Histidine	71-74	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	158-240
8639599-3	1996	Holocytochrome b5, the protein with iron protoporphyrin-IX liganded to His-39 and His-63, contains in sequence the following elements of secondary structure: beta 1-alpha 1-beta 4-beta 3-alpha 2-alpha 3-beta 5-alpha 4-alpha 5-beta 2-alpha 6 [Mathews, F.S., Czerwinski, E. W., &amp; Argos, P. (1979) The Porphyrins, Vol.	Histidine	82-85	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	158-240
15611058-4	2005	Here, we have detergent-solubilized, purified, and reconstituted enzymatically active His-tagged Ste14p from S. cerevisiae, thus providing conclusive proof that Ste14p is the sole component necessary for the carboxylmethylation of isoprenylated substrates.	Histidine	86-89	protein-S-isoprenylcysteine carboxyl O-methyltransferase	Saccharomyces cerevisiae S288C	161-167
8664285-16	1996	These findings indicate that the sulfated tyrosine/anionic GP Ibalpha residues Tyr-276-Glu-282 are important for the binding of thrombin and botrocetin-dependent binding of thrombin and the botrocetin-dependent binding of vWF, but that vWF also interacts with residues within His-1-Leu-275.	Histidine	276-279	glycoprotein Ib platelet subunit alpha	Homo sapiens	59-69
15667209-10	2005	The nonaged hBChE structure shows one water molecule interacting with Glu197 and the catalytic triad histidine (His438).	Histidine	101-110	butyrylcholinesterase	Homo sapiens	12-17
8638712-8	1996	We concluded that gastrin, acting through "gastrin/CCK-B type" receptors coupled to PTX-sensitive G protein, exerts a short-term regulation of histamine synthesis in gastric ECL cells by increasing both the affinity of HDC for L-histidine and the number of active enzyme molecules.	Histidine	227-238	gastrin/cholecystokinin type B receptor	Oryctolagus cuniculus	51-56
8596021-8	1996	Definitive evidence for the relationship between the 55-kDa peptide and the TCR alpha-chain was obtained by transfection of the cDNA of the TCR alpha-chain with histidine tag into the 231F1 cells.	Histidine	161-170	T cell receptor alpha locus	Homo sapiens	76-85
8596021-8	1996	Definitive evidence for the relationship between the 55-kDa peptide and the TCR alpha-chain was obtained by transfection of the cDNA of the TCR alpha-chain with histidine tag into the 231F1 cells.	Histidine	161-170	T cell receptor alpha locus	Homo sapiens	140-149
13845398-0	1959	Effect of sarcoma RD3 on intestinal active absorption of glucose and L-histidine.	Histidine	69-80	RD3 regulator of GUCY2D	Homo sapiens	18-21
15684398-3	2005	CPSF-73 contains a zinc-binding histidine motif involved in catalysis in other members of the beta-lactamase superfamily, whereas CPSF-100 has substitutions within the histidine motif and thus is unlikely to be catalytically active.	Histidine	168-177	cleavage and polyadenylation specific factor 2	Homo sapiens	130-138
34032009-0	2021	beta-Actin Peptide-Based Inhibitors of Histidine Methyltransferase SETD3.	Histidine	39-48	POTE ankyrin domain family member F	Homo sapiens	0-10
34032009-1	2021	SETD3 was recently identified as the histidine methyltransferase responsible for N 3 -methylation of His73 of beta-actin in humans.	Histidine	37-46	POTE ankyrin domain family member F	Homo sapiens	110-120
8652553-8	1996	The functional importance of Trp-139 is also demonstrated by the finding that its replacement by Phe, His, Pro, or Ala gives mutant enzymes that are optimally active at temperatures below that of the wild-type enzyme and undergo the E-PLP --&gt; E-PMP transition as a function of D-Ala concentration with reduced efficiency.	Histidine	102-105	proteolipid protein 1	Homo sapiens	235-238
8547274-2	1996	First, a mutant of annexin V was constructed with an N-terminal extension of six amino acids (Met-Ala-Cys-Asp-His-Ser) and with Cys316 mutated to Ser; this molecule was expressed in Escherichia coli.	Histidine	110-113	annexin A5	Rattus norvegicus	19-28
15642354-2	2005	LZT subfamily sequences all contain a unique and highly conserved metalloprotease motif (HEXPHEXGD) in transmembrane domain V with both histidine residues essential for zinc transport by ZIP (Zrt-, Irt-like Proteins) transporters.	Histidine	136-145	zinc finger CCCH-type and G-patch domain containing	Homo sapiens	187-190
33890127-8	2021	H-MP1 is a synthetic analog of MP1 with lysines replaced by histidines.	Histidine	60-70	pitrilysin metallopeptidase 1	Homo sapiens	2-5
15668489-3	2005	Nonsynonymous variants of EPHX1 at Tyr(113)His (exon 3) and His(139)Arg (exon 4) are associated, respectively, with low ((113)His) and high ((139)Arg) predicted activity.	Histidine	43-46	epoxide hydrolase 1	Homo sapiens	26-31
33922150-2	2021	Here, we investigate the effects of the pH solution on MP1 (IDWKKLLDAAKQIL-NH2) adsorption to anionic (7POPC:3POPG) lipid vesicles in comparison to its analog H-MP1, with histidines substituting lysines.	Histidine	171-181	pitrilysin metallopeptidase 1	Homo sapiens	55-58
8573177-0	1996	GTP, a nonsubstrate of ATP citrate lyase, is a phosphodonor for the enzyme histidine autophosphorylation.	Histidine	75-84	ATP citrate lyase	Homo sapiens	23-40
15664159-5	2005	RTA also autoregulated its own polyubiquitination and stability, and both activities were abolished by point mutations in a Cys plus His-rich N-terminal domain.	Histidine	133-136	MAS related GPR family member F	Homo sapiens	0-3
8769716-4	1996	The case showed CAT at codon 273 instead of wild-type CGT, substituting the encoded amino acid form histidine to arginine.	Histidine	100-109	UDP glycosyltransferase 8	Homo sapiens	54-57
32671530-8	2021	ICA reversed the HI-induced reduction in phosphorylated Akt and activation of cleaved caspase-3.	Histidine	17-19	caspase 3	Mus musculus	86-95
15666128-7	2005	Caspase-3 inhibitor (Ac-Asp-Glu-Val-Asp-CHO) and caspase-9 inhibitor (Ac-Leu-Glu-His-Asp-CHO) completely inhibited this DNA fragmentation.	Histidine	81-84	caspase 9	Homo sapiens	49-58
33601878-3	2021	In each module, genes with the most connectivity were selected as hub genes, including G antigen 12J (GAGE12J) in blue, proline, histidine and glycine rich 1 (PHGR1) in dark orange, DNA polymerase gamma 2, accessory subunit (POLG2) in dark red and collagen type XXI alpha 1 chain (COL21A1) in dark violet.	Histidine	129-138	ELAV like RNA binding protein 2	Homo sapiens	66-69
8811462-1	1996	The extracellular domain of the TSH receptor (TSHR-561, amino acids #78-389) was expressed as a hexa-histidine fusion protein in bacteria.	Histidine	101-110	thyroid stimulating hormone receptor	Homo sapiens	32-44
8811462-1	1996	The extracellular domain of the TSH receptor (TSHR-561, amino acids #78-389) was expressed as a hexa-histidine fusion protein in bacteria.	Histidine	101-110	thyroid stimulating hormone receptor	Homo sapiens	46-50
8548458-2	1996	The Class I glutamine amidotransferase domain of GMP synthetase is found in related enzymes of the purine, pyrimidine, tryptophan, arginine, histidine and folic acid biosynthetic pathways.	Histidine	141-150	guanine monophosphate synthase	Homo sapiens	49-63
8537336-5	1995	A close comparison with the human P2Y2 sequence reveals the conservation of histidine 262, arginine 265, lysine 289, and arginine 292, which were reported to be involved in nucleotide binding (Erb, L., Garrad, R., Wang, Y., Quinn, T., Turner, J. T., and Weisman, G. A.	Histidine	76-85	purinergic receptor P2Y2	Homo sapiens	34-38
18404403-5	2004	Amino acid substitutions at His-132, located in the third transmembrane domain (TM3) of the hP2Y(1) receptor, delayed the onset of channel opening, but not the kinetics of the activation process.	Histidine	28-31	purinergic receptor P2Y1	Homo sapiens	92-108
8545129-6	1995	We have since screened for genes in the vicinity of the insertion point and have identified a gene that is equivalent to the murine TIS11d gene, a member of TIS11 early response gene family, that contains unique Cysteine-Histidine motifs.	Histidine	221-230	zinc finger protein 36	Mus musculus	132-138
8545129-6	1995	We have since screened for genes in the vicinity of the insertion point and have identified a gene that is equivalent to the murine TIS11d gene, a member of TIS11 early response gene family, that contains unique Cysteine-Histidine motifs.	Histidine	221-230	zinc finger protein 36	Mus musculus	132-137
33226214-3	2020	Previously, we found that the Sec-devoid His-rich motif of selenoprotein P (Selenop-H) suppressed metal-induced aggregation and neurotoxicities of both Abeta and tau in vitro.	Histidine	41-44	selenoprotein P	Mus musculus	59-74
18404403-7	2004	Replacement of His-132 in the hP2Y(1) receptor with either Ala or Phe increased Zn(2+) sensitivity of the T(in) current.	Histidine	15-18	purinergic receptor P2Y1	Homo sapiens	30-46
7544128-2	1995	An anti-peptide antibody targeted to the C-terminus of CYP7 was produced by immunising rabbits with the synthetic peptide Tyr-Lys-Leu-Lys-His.	Histidine	138-141	cytochrome P450 7A1	Oryctolagus cuniculus	55-59
15550245-6	2004	Remarkably, the Fe(II)-heme group in AHSP bound alphaHb is coordinated by the distal but not the proximal histidine.	Histidine	106-115	alpha hemoglobin stabilizing protein	Homo sapiens	37-41
7628475-2	1995	Thus, of the three His residues contained in adrenodoxin, His56 is closest to Tyr82, and hence to the highly acidic determinant region of adrenodoxin that is the interaction site for adrenodoxin reductase and P-450.	Histidine	19-22	ferredoxin reductase	Bos taurus	183-204
32592084-2	2020	Histidine recognition was effected by histidyl-tRNA synthetase (HisRS), and its detection was signaled colorimetrically based on the molybdenum blue reaction.	Histidine	0-9	histidyl-tRNA synthetase 1	Homo sapiens	38-62
32592084-2	2020	Histidine recognition was effected by histidyl-tRNA synthetase (HisRS), and its detection was signaled colorimetrically based on the molybdenum blue reaction.	Histidine	0-9	histidyl-tRNA synthetase 1	Homo sapiens	64-69
15648971-0	2004	Do alkylating agents modify the histidine residue of the desensitized butyrylcholinesterase?	Histidine	32-41	butyrylcholinesterase	Homo sapiens	70-91
33090265-11	2020	Furthermore, positive correlations were observed when comparing plasma DAO activity with histidine, proline, cystine, arginine, and glutamine concentrations.	Histidine	89-98	D-amino acid oxidase	Bos taurus	71-74
33000155-5	2020	Excess histidine may be converted to trans-urocanate by histidine ammonia lyase (histidase) in liver and skin.	Histidine	7-16	histidine ammonia-lyase	Homo sapiens	56-79
7607641-4	1995	DNA sequence analysis of polymerase chain reaction (PCR)-amplified DNA of all six LCAT exons revealed a new point mutation in exon IV of the LCAT gene, i.e., a G to A substitution in codon 140 converting Arg to His.	Histidine	211-214	lecithin-cholesterol acyltransferase	Homo sapiens	82-86
7607641-4	1995	DNA sequence analysis of polymerase chain reaction (PCR)-amplified DNA of all six LCAT exons revealed a new point mutation in exon IV of the LCAT gene, i.e., a G to A substitution in codon 140 converting Arg to His.	Histidine	211-214	lecithin-cholesterol acyltransferase	Homo sapiens	141-145
7754945-4	1995	Histidine at position 30 of the HLA-DQB1 gene was associated with disease (62% of patients compared to 36% of controls), whereas homozygosity for leucine at position 26 was more frequent in controls (36% vs 18% of patients).	Histidine	0-9	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	32-40
33000155-5	2020	Excess histidine may be converted to trans-urocanate by histidine ammonia lyase (histidase) in liver and skin.	Histidine	7-16	histidine ammonia-lyase	Homo sapiens	81-90
15648971-2	2004	The effects of TPCK and TLCK on the histidine in the catalytic triad of the desensitized butyrylcholinesterase (BChE), prepared from human serum by heating at 45 degrees C for 24 h, were investigated in detail.	Histidine	36-45	butyrylcholinesterase	Homo sapiens	89-110
32879443-6	2020	Moreover, the mutation of histidine 200 of JMJD8 (JMJD8-H200Q) disrupted its binding with AKT1 and increased interaction of SETDB1 and PDK1 with AKT1.	Histidine	26-35	pyruvate dehydrogenase kinase 1	Homo sapiens	135-139
15648971-2	2004	The effects of TPCK and TLCK on the histidine in the catalytic triad of the desensitized butyrylcholinesterase (BChE), prepared from human serum by heating at 45 degrees C for 24 h, were investigated in detail.	Histidine	36-45	butyrylcholinesterase	Homo sapiens	112-116
15648974-0	2004	Kinetics of histidine dissociation from the heme Fe(III) in N-fragment (residues 1-56) of cytochrome c.	Histidine	12-21	cytochrome c, somatic	Equus caballus	90-102
15358373-0	2004	Expression and purification of His-tagged rat mitochondrial medium-chain acyl-CoA dehydrogenase wild-type and Arg256 mutant proteins.	Histidine	31-34	acyl-CoA dehydrogenase medium chain	Rattus norvegicus	60-95
32046993-3	2020	OBJECTIVE: We report the clinical experience and physician evaluation of this new detector system with Hi-Def mode for the treatment of intracranial aneurysms using a Pipeline embolization device (PED).	Histidine	103-105	UTP25 small subunit processome component	Homo sapiens	106-109
7590793-2	1995	The anti-TRH antibodies were raised by immunization with a TRH-bovine serum albumin conjugate obtained by coupling of the CO2H group of pGlu-His-Pro-OH to NH2 groups in the protein.	Histidine	141-144	thyrotropin releasing hormone	Mus musculus	9-12
7590793-2	1995	The anti-TRH antibodies were raised by immunization with a TRH-bovine serum albumin conjugate obtained by coupling of the CO2H group of pGlu-His-Pro-OH to NH2 groups in the protein.	Histidine	141-144	thyrotropin releasing hormone	Mus musculus	59-62
7590793-5	1995	Characterization of the anti-TRH antibodies showed that in general they are specific for the pGlu-His moiety.	Histidine	98-101	thyrotropin releasing hormone	Mus musculus	29-32
7590793-7	1995	The specificities of these antibodies are markedly different from those previously obtained using TRH coupled through the histidine residue to protein as the immunogen.	Histidine	122-131	thyrotropin releasing hormone	Mus musculus	98-101
15358373-2	2004	We cloned the gene of rat mitochondrial medium-chain acyl-CoA dehydrogenase into a bacterial expression vector pLM1 with six continuous histidine codons attached to the 3" of the gene.	Histidine	136-145	acyl-CoA dehydrogenase medium chain	Rattus norvegicus	40-75
32787066-1	2020	The histidine-rich antimicrobial peptides (AMPs) Gad-1 and Gad-2, from paralogous genes in cod, provide an opportunity to examine the effect of charge and non-electrostatic factors on peptide-vesicle interaction and on peptide antimicrobial activity.	Histidine	4-13	glutamate decarboxylase 1	Homo sapiens	49-54
7759520-8	1995	The ESR spectrum of high-spin cytochrome b558 was identical to that of methemoglobin, suggesting that the axial-ligand type in both hemoproteins may be the same, i.e. histidine is the fifth ligand.	Histidine	167-176	cytochrome b	Sus scrofa	30-42
32973811-4	2020	We found that multiple immunizations of HIS-CD8/NKT mice with the nanovaccine resulted in the activation and/or expansion of human CD141+ DCs and iNKT cells and ultimately elicited a potent Melan-A-specific CD8+ T cell response, as determined by tetramer staining and ELISpot assay.	Histidine	40-43	CD8a molecule	Homo sapiens	44-47
15302581-1	2004	As part of a study to identify novel transcriptional regulators of chondrogenesis-related gene expression, we have cloned and characterized cDNA for zinc-finger protein 470 (ZNF470), the human ortholog of which encodes a 717 amino acid residue protein containing 17 Cys(2)His(2) zinc-finger domains, as well as KRAB-A and KRAB-B motifs.	Histidine	272-275	zinc finger protein 470	Homo sapiens	149-172
7761440-4	1995	In contrast, the three-dimensional structure of threonine-199--&gt;histidine (T199H) CAII, determined to 2.25-Angstrum resolution, indicates that the engineered imidazole side chain rotates away from the metal and does not coordinate to zinc; this results in a weaker zinc-binding site.	Histidine	67-76	carbonic anhydrase 2	Homo sapiens	85-89
15302581-1	2004	As part of a study to identify novel transcriptional regulators of chondrogenesis-related gene expression, we have cloned and characterized cDNA for zinc-finger protein 470 (ZNF470), the human ortholog of which encodes a 717 amino acid residue protein containing 17 Cys(2)His(2) zinc-finger domains, as well as KRAB-A and KRAB-B motifs.	Histidine	272-275	zinc finger protein 470	Homo sapiens	174-180
7737993-5	1995	In a recent study, we have shown that GroEL interacts preferentially with the side chains of hydrophobic amino acids (Ile, Phe, Val, Leu, and Trp) and more weakly with several polar or charged amino acids, including the strongest alpha-helix and beta-sheet formers (Glu, Gln, His, Thr, and Tyr).	Histidine	276-279	heat shock protein family D (Hsp60) member 1	Homo sapiens	38-43
32664726-0	2020	Detection of OG:A lesion mispairs by MutY relies on a single His residue and the 2-amino group of 8-oxoguanine.	Histidine	61-64	mutY DNA glycosylase	Homo sapiens	37-41
32664726-3	2020	Herein we use a combination of in vitro and bacterial cell repair assays with single molecule fluorescence microscopy to demonstrate that both a C-terminal domain histidine residue and the 2-amino group of OG base are critical for MutY detection of OG:A sites.	Histidine	163-172	mutY DNA glycosylase	Homo sapiens	231-235
15791490-7	2004	The recombinant protein of flounder ODC containing a short histidine tag at the carboxyl terminus was overexpressed in Escherichia coli BL21 (DE3) codon plus using an inducible T7 expression system, and was purified by Ni-NTA affinity chromatography.	Histidine	59-68	ornithine decarboxylase 1	Danio rerio	36-39
32448098-8	2021	The major hot spot amino acids involved in the binding identified by interaction analysis after simulations includes Glu 35, Tyr 83, Asp 38, Lys 31, Glu 37, His 34 amino acid residues of ACE2 receptor and Gln 493, Gln 498, Asn 487, Tyr 505 and Lys 417 residues in nCoV S-protein RBD.	Histidine	157-160	vitronectin	Homo sapiens	269-278
7896796-7	1995	The amino-terminal incompatibility site was identified as position 5 (Ile in PTH and His in PTHrP), because Ile5-hybrid-1 bound with high affinity (IC50 approximately equal to 20 nM).	Histidine	85-88	parathyroid hormone-like hormone	Rattus norvegicus	92-97
15367352-8	2004	Western blot analysis showed that the anti-PRL-2 polyclonal antibody can recognize 6 x His-PRL-2 fusion protein.	Histidine	87-90	protein tyrosine phosphatase 4A2	Homo sapiens	43-48
7880816-7	1995	ADR1 mutants with either His or Lys in the central +3 residue (146) of zinc finger two, which have Arg149 in the +6 alpha-helical position, bind with UAS1 mutant sequences having G5 very strongly, T5 strongly, A5 intermediately, and C5 weakly.	Histidine	25-28	DNA-binding transcription factor ADR1	Saccharomyces cerevisiae S288C	0-4
32492011-7	2020	Nevertheless, Ngb contains both proximal and distal conserved heme-biding histidines.	Histidine	74-84	neuroglobin	Homo sapiens	14-17
15367352-8	2004	Western blot analysis showed that the anti-PRL-2 polyclonal antibody can recognize 6 x His-PRL-2 fusion protein.	Histidine	87-90	protein tyrosine phosphatase 4A2	Homo sapiens	91-96
15236690-0	2004	Chromatographic purification of an insoluble histidine tag recombinant Ykt6p SNARE from Arabidopsis thaliana over-expressed in E. coli.	Histidine	45-54	palmitoyltransferase YKT6	Saccharomyces cerevisiae S288C	71-76
7852403-4	1995	The results suggest that pyridine induces a structural modification in the heme environment of cytochrome b558 by shifting the 5th heme ligand (histidine) to a nearby thiolate group without direct binding of pyridine to the heme.	Histidine	144-153	cytochrome b	Sus scrofa	95-107
7852330-2	1995	In the present investigation, we targeted Trp and His residues in human serum vitamin D-binding protein (hDBP) by modifying them with specific chemical modifiers.	Histidine	50-53	GC vitamin D binding protein	Homo sapiens	78-103
32496146-10	2020	The hydrogen-bonding interaction of T3 with TRalpha at His-381 was also shared by majority of analogs.	Histidine	55-58	T cell receptor alpha locus	Homo sapiens	44-51
15272307-1	2004	Mammalian formiminotransferase cyclodeaminase (FTCD), a 0.5 million Dalton homo-octameric enzyme, plays important roles in coupling histidine catabolism with folate metabolism and integrating the Golgi complex with the vimentin intermediate filament cytoskeleton.	Histidine	132-141	vimentin	Homo sapiens	219-227
7852330-7	1995	These results strongly emphasized the importance of Trp (single residue at position 145) and 1 His residue (out of a total of 6) in the vitamin D sterol-binding by vitamin D-binding protein.	Histidine	95-98	GC vitamin D binding protein	Homo sapiens	164-189
7847389-4	1995	A genomic polymorphism of LMP7 was found strongly associated with IDDM, and the Arg/His-60 polymorphism in LMP2 was found associated with IDDM only in subjects containing an HLA DR4-DQB1*0302 haplotype.	Histidine	84-87	major histocompatibility complex, class II, DR beta 4	Homo sapiens	178-181
32210794-7	2020	The molecular docking and further experiments demonstrated that HgCl2 bound to the amino residuals (His) in the catalytic center of tyrosinase.	Histidine	100-103	tyrosinase	Homo sapiens	132-142
15161915-10	2004	Based on the NK1 domain structure, we propose that copper(II) may interact with HGF via the histidine residues in either N-terminal or kringle domains.	Histidine	92-101	tachykinin receptor 1	Homo sapiens	13-16
15238222-2	2004	We have isolated a cDNA encoding an isoform of CCT from Drosophila melanogaster and expressed the recombinant native and 6 x -His-tagged forms using a baculovirus expression system in Spodoptera frugiperda (Sf9) insect cells.	Histidine	126-129	Phosphocholine cytidylyltransferase 1	Drosophila melanogaster	47-50
33390398-8	2020	The mRNA levels of PPARgamma, LXRalpha, and AMPKalpha in the liver were also reduced by excess histidine intake.	Histidine	95-104	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	19-28
7851422-5	1995	Proline residues of helix 6, that are conserved in all human glucose-transporter isoforms except for the human GLUT2, were mutated either to alanine or to the corresponding residues of GLUT2, i.e. to histidine (P187H), arginine (P196R) or phenylalanine (P205F).	Histidine	200-209	solute carrier family 2 member 2	Homo sapiens	185-190
15177288-5	2004	In this study, we have cloned, overexpressed, and characterized the entire coding region and the cytoplasmic domain of PknI as a fusion protein with an N-terminal histidine tag, and used immobilized metal affinity chromatography for purification of recombinant proteins.	Histidine	163-172	serine/threonine-protein kinase PknI	Mycobacterium tuberculosis H37Rv	119-123
7599635-0	1995	Four new adenosine deaminase mutations, altering a zinc-binding histidine, two conserved alanines, and a 5" splice site.	Histidine	64-73	adenosine deaminase	Homo sapiens	9-28
7723755-0	1995	[Dynamic mobility of the histidine-containing domain of spin-labeled lysozyme].	Histidine	25-34	spindlin 1	Homo sapiens	56-60
7723755-1	1995	The hen egg-white lysozyme was modified by the spin label (2,2,6,6-tetramethylpiperidine-N1-oxyl-4-iodacetamide) at the single histidine residue His-15.	Histidine	127-136	spindlin 1	Homo sapiens	47-51
7723755-1	1995	The hen egg-white lysozyme was modified by the spin label (2,2,6,6-tetramethylpiperidine-N1-oxyl-4-iodacetamide) at the single histidine residue His-15.	Histidine	145-148	spindlin 1	Homo sapiens	47-51
32880207-12	2020	Arg39 is also predicted to alter the pK A of a key catalytic histidine residue at position 160, further attenuating ARG2"s enzymatic function.	Histidine	61-70	arginase 2	Homo sapiens	116-120
15194871-5	2004	We found that mutation of leucine 958, leucine 973 or histidine 974 or deletion of a spacer sequence of more than six amino acids between leucine 958 and histidine 974 disrupted the NR3A/PP2A interaction.	Histidine	54-63	glutamate ionotropic receptor NMDA type subunit 3A	Homo sapiens	182-186
7998988-7	1994	Alignment with subtilisin-like serine peptidases identified Asp44, His264 and Ser449 as the catalytic triad, thus defining an extra domain of approximately 200 amino acids between the catalytic Asp and His in TPP II as compared with other subtilases.	Histidine	67-70	tripeptidyl peptidase II	Mus musculus	209-215
15194871-5	2004	We found that mutation of leucine 958, leucine 973 or histidine 974 or deletion of a spacer sequence of more than six amino acids between leucine 958 and histidine 974 disrupted the NR3A/PP2A interaction.	Histidine	154-163	glutamate ionotropic receptor NMDA type subunit 3A	Homo sapiens	182-186
31502464-5	2019	Modified forms of SUMO1 or SUMO2, with a histidine tag and a Thr to Lys mutation preceding the carboxyl-terminal di-gly motif, were expressed in mpkCCD14 cells, allowing SUMO-conjugated proteins to be purified and identified.	Histidine	41-50	small ubiquitin like modifier 2	Homo sapiens	27-32
15194871-5	2004	We found that mutation of leucine 958, leucine 973 or histidine 974 or deletion of a spacer sequence of more than six amino acids between leucine 958 and histidine 974 disrupted the NR3A/PP2A interaction.	Histidine	154-163	protein phosphatase 2 phosphatase activator	Homo sapiens	187-191
15196918-4	2004	In the CO-bound form of OxdA, the correlation between the Fe-CO stretching (512 cm(-1)) and C-O stretching (1950 cm(-1)) frequencies also supports our assignment of proximal histidine coordination.	Histidine	174-183	D-amino acid oxidase	Homo sapiens	24-28
31254495-1	2019	PHT2, a member of the proton-coupled oligopeptide transporter family, participates in the transportation of small peptides and histidine from lysosomes to the cytosol.	Histidine	127-136	solute carrier family 15 member 3	Homo sapiens	0-4
7969132-9	1994	This GCN2-independent pathway was also stimulated to a lesser extent by the multicopy tRNA(His) constructs in histidine-deprived cells.	Histidine	110-119	serine/threonine-protein kinase GCN2	Saccharomyces cerevisiae S288C	5-9
7947988-0	1994	Site-directed mutagenesis of human ferrochelatase: identification of histidine-263 as a binding site for metal ions.	Histidine	69-78	ferrochelatase	Homo sapiens	35-49
7947988-3	1994	To attempt to clarify the binding site of ferrous ion, we converted four highly conserved histidine residues in human ferrochelatase to alanine, using site-directed mutagenesis.	Histidine	90-99	ferrochelatase	Homo sapiens	118-132
7947988-10	1994	These results indicate that the binding site for metal ions in ferrochelatase is distinct from that for the porphyrin, and suggest that histidine-263 contributes significantly to the binding of metal ions.	Histidine	136-145	ferrochelatase	Homo sapiens	63-77
15034050-0	2004	Mutational analyses of the recombinant globular regions of human C1q A, B, and C chains suggest an essential role for arginine and histidine residues in the C1q-IgG interaction.	Histidine	131-140	complement C1q A chain	Homo sapiens	65-80
7947684-0	1994	Eight histidine residues are catalytically essential in a membrane-associated iron enzyme, stearoyl-CoA desaturase, and are conserved in alkane hydroxylase and xylene monooxygenase.	Histidine	6-15	stearoyl-CoA desaturase	Rattus norvegicus	91-114
7947684-7	1994	In order to examine the functional role of these conserved His residues, we have made use of the ability of the rat delta 9 desaturase gene to complement a yeast strain deficient in the delta 9 desaturase gene function (ole1).	Histidine	59-62	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	220-224
7947684-10	1994	In contrast, mutation of three nonconserved flanking His residues or a partially conserved Arg residue within the conserved motif to Ala allowed for complementation of the ole1 phenotype.	Histidine	53-56	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	172-176
30937958-3	2019	We found that an HSL protein with a His-tag at the N-terminus preserved the normal hydrolase activity of cholesteryl ester (CE) but the triglyceride lipase (TG) activity significantly decreased in vitro.	Histidine	36-39	lipase, hormone sensitive	Mus musculus	17-20
30937958-6	2019	To compare His-HSL and wild-type HSL in vitro and in vivo, we confirmed that the His-tag significantly suppressed HSL TG activity.	Histidine	11-14	lipase, hormone sensitive	Mus musculus	15-18
15034050-0	2004	Mutational analyses of the recombinant globular regions of human C1q A, B, and C chains suggest an essential role for arginine and histidine residues in the C1q-IgG interaction.	Histidine	131-140	complement C1q A chain	Homo sapiens	65-68
15034050-6	2004	Because C1q is a charge pattern recognition molecule, we have sequentially targeted arginine and histidine residues in each chain.	Histidine	97-106	complement C1q A chain	Homo sapiens	8-11
31152065-4	2019	Ddi2 enzymatically hydrates cyanamide to urea and belongs to the family of HD-domain metalloenzymes (named after conserved active-site metal-binding His and Asp residues).	Histidine	149-152	cyanamide hydratase	Saccharomyces cerevisiae S288C	0-4
7848918-4	1994	This complementary DNA, designated Kiz-1, encodes a protein containing two prominent domains; the NH2-terminal region contains a cysteine/histidine-rich moiety previously identified as a zinc-finger domain in proteins of the LIM family, while the COOH-terminus contains a kinase domain.	Histidine	138-147	LIM-domain containing, protein kinase	Mus musculus	35-40
15034050-7	2004	Consistent with previous chemical modification studies and the recent crystal structure of gC1q, our results support a central role for arginine and histidine residues, especially Arg(114) and Arg(129) of the ghB module, in the C1q-IgG interaction.	Histidine	149-158	complement C1q A chain	Homo sapiens	92-95
31164399-8	2019	This work helps to establish the structure/function relationship of ZIP4 and also sheds light on other metal transporters and metalloproteins with clustered histidine residues.	Histidine	157-166	solute carrier family 39 member 4	Homo sapiens	68-72
15049834-5	2004	The Thz ring, protecting both the amino and thiol groups in Nin-Cys, completely avoids the formylation and Thz side reactions found during hydrofluoric acid (HF) cleavage when N-pi-benzyloxymethyl histidine groups are present.	Histidine	197-206	ninein	Homo sapiens	60-63
31209258-5	2019	Here, we developed pro-TGFbeta2 production systems based on human Expi293F cells, which yielded >2 mg of pure histidine- or Strep-tagged protein per liter of cell culture.	Histidine	110-119	transforming growth factor beta 2	Homo sapiens	23-31
8076694-3	1994	Chemical modification of cysteine by iodoacetic acid, and histidine by diethylpyrocarbonate, resulted in a near complete inhibition of 65Zn-binding to TP2.	Histidine	58-67	transition protein 2	Rattus norvegicus	151-154
8187056-2	1994	In DNA from one tumor we found that the histidine codon 193 (CAT) was somatically converted to arginine (CGT).	Histidine	40-49	UDP glycosyltransferase 8	Homo sapiens	105-108
7511204-5	1994	P58, expressed as a histidine fusion protein in Escherichia coli, blocked both the autophosphorylation of PKR and phosphorylation of the alpha subunit of eIF-2.	Histidine	20-29	interferon induced protein with tetratricopeptide repeats 5	Homo sapiens	0-3
14989719-4	2004	The sequence of B*5809 is identical to that of HLA-B*5801, except for a point mutation at position 583 in exon 3, where a T is substituted by a C. This change leads to an amino acidic substitution from Tyr (TAC) to His (CAC) at codon 171.	Histidine	215-218	major histocompatibility complex, class I, B	Homo sapiens	47-52
8132511-2	1994	Site-directed mutagenesis was used to replace His-163 in the Loop 1 region of the recA protein with a tryptophan residue.	Histidine	46-49	RAD51 recombinase	Homo sapiens	82-86
8300595-7	1994	Both mutant phenotypes are dominant over wild-type VirA, and both need the conserved histidine at the autophosphorylation site for strong inducer-independent vir transcription.	Histidine	85-94	two-component VirA-like sensor kinase	Agrobacterium tumefaciens	51-55
31197133-2	2019	Here, we report designed ankyrin repeat proteins (DARPins) macromolecules that specifically inhibit the KRAS isoform by binding to an allosteric site encompassing the region around KRAS-specific residue histidine 95 at the helix alpha3/loop 7/helix alpha4 interface.	Histidine	203-212	KRAS proto-oncogene, GTPase	Homo sapiens	104-108
14560312-5	2004	The exchanges of arginine to histidine, found in two unrelated patients with TRPS I, as well as the exchange of arginine to cysteine, found in another unrelated patient, prevent the translocation of the mutant TRPS1 to the nucleus when ectopically expressed in COS 7 cells.	Histidine	29-38	transcriptional repressor GATA binding 1	Homo sapiens	210-215
31197133-2	2019	Here, we report designed ankyrin repeat proteins (DARPins) macromolecules that specifically inhibit the KRAS isoform by binding to an allosteric site encompassing the region around KRAS-specific residue histidine 95 at the helix alpha3/loop 7/helix alpha4 interface.	Histidine	203-212	KRAS proto-oncogene, GTPase	Homo sapiens	181-185
30317586-0	2019	A pH-sensitive luminal His-cluster promotes interaction of PAM with V-ATPase along the secretory and endocytic pathways of peptidergic cells.	Histidine	23-26	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	59-62
8043649-9	1994	In the presence of cAMP, only one histidine participates in the binding process, indicating an asymmetric interaction between the two subunits of the CRP and the DNA.	Histidine	34-43	catabolite gene activator protein	Escherichia coli	150-153
7866410-0	1994	Marked zinc activation of ester hydrolysis by a mutation, 67-His (CAT) to Arg (CGT), in the active site of human carbonic anhydrase I.	Histidine	61-64	UDP glycosyltransferase 8	Homo sapiens	79-82
7866410-0	1994	Marked zinc activation of ester hydrolysis by a mutation, 67-His (CAT) to Arg (CGT), in the active site of human carbonic anhydrase I.	Histidine	61-64	carbonic anhydrase 1	Homo sapiens	113-133
30826412-8	2019	Furthermore, based on the in vivo neutralization assay, recombinant His-beta-actin accelerated the infection of WSSV, conversely, recombinant His-Rab7 delayed WSSV infection in shrimp.	Histidine	68-71	POTE ankyrin domain family member F	Homo sapiens	72-82
14763985-6	2004	Mutations in the conserved cysteine- and histidine-rich regions and ATPase and helicase motifs of Upf1p separate the ability of Upf1p to complement the respiratory impairment of a Deltaupf1 strain from its ability to act as a multicopy suppressor of mitochondrial splicing deficiency, indicating that distinct pathways express these phenotypes.	Histidine	41-50	ATP-dependent RNA helicase NAM7	Saccharomyces cerevisiae S288C	128-133
30804004-6	2019	This study suggests that perturbations in histidine metabolism selectively target neural tumours that grow via a dedifferentiation process involving large cell size increases driven by Myc.	Histidine	42-51	Myc	Drosophila melanogaster	185-188
30593504-0	2019	An extracellular histidine-containing motif in the zinc transporter ZIP4 plays a role in zinc sensing and zinc-induced endocytosis in mammalian cells.	Histidine	17-26	solute carrier family 39 member 4	Homo sapiens	68-72
8142888-0	1994	Positions of His-64 and a bound water in human carbonic anhydrase II upon binding three structurally related inhibitors.	Histidine	13-16	carbonic anhydrase 2	Homo sapiens	47-68
14760716-5	2004	Here we present a simple procedure to isolate and separate proteins that contain redox active cysteines using a site-directed, histidine-tagged mutant of thioredoxin, which forms stable mixed disulphides with its targets.	Histidine	127-136	thioredoxin	Homo sapiens	154-165
8136024-3	1993	The further substitution of Asp for B10 His in [B16 Phe, B26 Phe]insulin raises its activity to approximately twofold greater than natural insulin, an increase of approximately fivefold over the parent compound.	Histidine	40-43	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	36-39
30593504-5	2019	In this study, we used mutational analysis, immunoblotting, HEK293 cells, and immunofluorescence microscopy to identify a histidine-containing motif (398HTH) in the first extracellular loop that is required for high sensitivity to low zinc concentrations in a zinc-induced endocytic response of mouse ZIP4 (mZIP4).	Histidine	122-131	solute carrier family 39 (zinc transporter), member 4	Mus musculus	301-305
30593504-5	2019	In this study, we used mutational analysis, immunoblotting, HEK293 cells, and immunofluorescence microscopy to identify a histidine-containing motif (398HTH) in the first extracellular loop that is required for high sensitivity to low zinc concentrations in a zinc-induced endocytic response of mouse ZIP4 (mZIP4).	Histidine	122-131	solute carrier family 39 (zinc transporter), member 4	Mus musculus	307-312
30593504-6	2019	Moreover, using synthetic peptides with selective substitutions and truncated mZIP4 variants, we provide evidence that histidine residues in this motif coordinate a zinc ion in mZIP4 homodimers at the plasma membrane.	Histidine	119-128	solute carrier family 39 (zinc transporter), member 4	Mus musculus	78-83
30593504-6	2019	Moreover, using synthetic peptides with selective substitutions and truncated mZIP4 variants, we provide evidence that histidine residues in this motif coordinate a zinc ion in mZIP4 homodimers at the plasma membrane.	Histidine	119-128	solute carrier family 39 (zinc transporter), member 4	Mus musculus	177-182
30785395-0	2019	Structural insights into SETD3-mediated histidine methylation on beta-actin.	Histidine	40-49	POTE ankyrin domain family member F	Homo sapiens	65-75
8218383-2	1993	The maximal rate of CO2 hydration catalyzed by human carbonic anhydrase II (carbonate hydro-lyase, EC 4.2.1.1) is limited by proton transfer steps involving the acid-base function of His-64.	Histidine	183-186	carbonic anhydrase 2	Homo sapiens	53-74
14734527-1	2004	The products of the human leukocyte antigen subtypes HLA-B*2705 and HLA-B*2709 differ only in residue 116 (Asp vs. His) within the peptide binding groove but are differentially associated with the autoimmune disease ankylosing spondylitis (AS); HLA-B*2705 occurs in AS-patients, whereas HLA-B*2709 does not.	Histidine	115-118	major histocompatibility complex, class I, B	Homo sapiens	53-58
8378358-3	1993	When various preparations of glyceraldehyde-3-phosphate dehydrogenase containing 0-7.0 equivalent of HNE-histidine residues per subunit were obtained by incubating samples of glyceraldehyde-3-phosphate dehydrogenase with increased amounts of HNE and subjected to immunoblotting with the HNE-specific antibody, the intensities of the blots were directly proportional to the number of HNE-histidine adducts as measured directly by amino acid analysis.	Histidine	105-114	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	29-69
8378358-3	1993	When various preparations of glyceraldehyde-3-phosphate dehydrogenase containing 0-7.0 equivalent of HNE-histidine residues per subunit were obtained by incubating samples of glyceraldehyde-3-phosphate dehydrogenase with increased amounts of HNE and subjected to immunoblotting with the HNE-specific antibody, the intensities of the blots were directly proportional to the number of HNE-histidine adducts as measured directly by amino acid analysis.	Histidine	387-396	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	29-69
30463969-4	2019	We previously characterized the role of two highly conserved histidine residues, H348 and H352, located in an external, juxtamembrane region of the E2 protein termed the D-loop.	Histidine	61-70	ubiquitin conjugating enzyme E2 B	Homo sapiens	148-158
14734527-1	2004	The products of the human leukocyte antigen subtypes HLA-B*2705 and HLA-B*2709 differ only in residue 116 (Asp vs. His) within the peptide binding groove but are differentially associated with the autoimmune disease ankylosing spondylitis (AS); HLA-B*2705 occurs in AS-patients, whereas HLA-B*2709 does not.	Histidine	115-118	major histocompatibility complex, class I, B	Homo sapiens	68-73
8221927-5	1993	At the same time we observed a high rate of reversion in the meth, his and trp loci of the cdc2-1 mutant under restrictive conditions.	Histidine	67-70	thymidylate synthase	Saccharomyces cerevisiae S288C	91-97
14734527-1	2004	The products of the human leukocyte antigen subtypes HLA-B*2705 and HLA-B*2709 differ only in residue 116 (Asp vs. His) within the peptide binding groove but are differentially associated with the autoimmune disease ankylosing spondylitis (AS); HLA-B*2705 occurs in AS-patients, whereas HLA-B*2709 does not.	Histidine	115-118	major histocompatibility complex, class I, B	Homo sapiens	68-73
8344434-1	1993	Mouse IgG1, IgG2a, and IgG2b proteins have been selectively labeled with 13C at the carbonyl carbon of His, Met, Trp or Tyr residue and used to prepare the corresponding Fc fragments by limited proteolysis.	Histidine	103-106	immunoglobulin heavy constant gamma 2B	Mus musculus	23-28
14734527-1	2004	The products of the human leukocyte antigen subtypes HLA-B*2705 and HLA-B*2709 differ only in residue 116 (Asp vs. His) within the peptide binding groove but are differentially associated with the autoimmune disease ankylosing spondylitis (AS); HLA-B*2705 occurs in AS-patients, whereas HLA-B*2709 does not.	Histidine	115-118	major histocompatibility complex, class I, B	Homo sapiens	68-73
15323354-2	2004	Analysis of known protein disulphide isomerase and thioredoxin sequences has revealed the presence of conserved Cys, His and Asp residues required for transglutaminases to catalyze the incorporation of primary amines into protein-bound glutamine residues.	Histidine	117-120	thioredoxin	Homo sapiens	51-62
13679373-7	2003	Pro-446, corresponding to the Pro/His mutation in dominant negative TLR4, is located in the third loop at the outmost edge of the TIR domain and does not play any structural role.	Histidine	34-37	toll like receptor 4	Homo sapiens	68-72
8341706-2	1993	The purification and characterization of the recombinant FKBP-52 (rFKBP-52) was facilitated by incorporating a histidine 6-mer domain at its N terminus.	Histidine	111-120	FKBP prolyl isomerase 4	Rattus norvegicus	57-64
8341706-2	1993	The purification and characterization of the recombinant FKBP-52 (rFKBP-52) was facilitated by incorporating a histidine 6-mer domain at its N terminus.	Histidine	111-120	FKBP prolyl isomerase 4	Rattus norvegicus	66-74
8318003-7	1993	Peak 1, a zinc-dependent enzyme with serine and histidine in the active site, exhibited an M(r) of 75,000 on Superose 12 and was poorly inhibited by V3 loop peptides.	Histidine	48-57	pseudopodium enriched atypical kinase 1	Homo sapiens	0-6
30728809-4	2019	Using molecular dynamics simulations, we demonstrate that ABBA binds to the "central cavity" in the elbow of vWbp by interacting with Arg-70, His-71, Ala-72, Gly-73, Tyr-74, Glu-75, Tyr-83, and Gln-87 in vWbp, thus interfering with the binding of vWbp to prothrombin.	Histidine	142-145	MTSS I-BAR domain containing 2	Mus musculus	58-62
30171712-5	2019	Site Finder and molecular docking defined the thiazolidinones interactions with the most important catalytic residues of DNase I, including the H-acceptor interaction with residues His 134 and His 252 and/or H-donor interaction with residues Glu 39 and Asp 168.	Histidine	181-184	deoxyribonuclease 1	Rattus norvegicus	121-128
30171712-5	2019	Site Finder and molecular docking defined the thiazolidinones interactions with the most important catalytic residues of DNase I, including the H-acceptor interaction with residues His 134 and His 252 and/or H-donor interaction with residues Glu 39 and Asp 168.	Histidine	193-196	deoxyribonuclease 1	Rattus norvegicus	121-128
8370667-2	1993	Both cDNAs were inserted into a baculovirus vector which mediated highly efficient expression of the human GAD65 and GAD67 with histidine-hexapeptides as affinity ligands at their C-termini in Spodoptera frugiperda (Sf9) cells.	Histidine	128-137	glutamate decarboxylase 1	Homo sapiens	117-122
14519080-8	2003	DAB(389)EGF is a fusion protein composed of the catalytic and translocation domains of diphtheria toxin fused via a His-Ala linker to human epidermal growth factor (EGF).	Histidine	116-119	epidermal growth factor	Homo sapiens	8-11
30604175-6	2019	Of those AtELOs, AtELO1 and AtELO2 had a characteristic histidine motif and were bound to AtCb5-B.	Histidine	56-65	Paxneb protein-like protein	Arabidopsis thaliana	17-23
12962478-3	2003	Resistin cDNA derived from human subcutaneous adipose tissue was expressed in Escherichia coli as an N-terminal six-His-tag fusion protein.	Histidine	116-119	resistin	Homo sapiens	0-8
30408622-6	2018	Meanwhile, mannitol, a ROS scavenger, could not protect against dissociation, which implied that local ROS from accessible histidine residues may be crucially beneficial to the formation of mCRP in a redox-balanced microenvironment.	Histidine	123-132	C-reactive protein, pentraxin-related	Mus musculus	190-194
8392938-4	1993	The histidine alkylating agent diethylpyrocarbonate potently inhibited binding of [125I]endothelin-1 to its receptors in bovine cerebellum, where a single population of endothelin ETB receptors was shown to exist.	Histidine	4-13	endothelin 1	Bos taurus	88-100
14518047-0	2003	Formation of S-[2-carboxy-1-(1H-imidazol-4-yl) ethyl]glutathione, a new metabolite of L-histidine, from cis-urocanic acid and glutathione by the action of glutathione S-transferase.	Histidine	86-97	hematopoietic prostaglandin D synthase	Rattus norvegicus	155-180
8320037-9	1993	The nucleotide sequence analyses demonstrated that the codon CGT for -2 Arg was mutated to CAT for His.	Histidine	99-102	UDP glycosyltransferase 8	Homo sapiens	61-64
30345437-5	2018	Indeed, in addition to the three-coordinated species containing one His ligand, a N-terminal amine group and the carboxylate side chain of the Asp1 residue of Abeta already proposed, we found two other Cu-Abeta coordination modes involving two histidines.	Histidine	244-254	beta-secretase 2	Homo sapiens	143-147
14578575-6	2003	The catalytic triad of serine proteinases of the subtilisin family was found at Asp-168, His-209, and Ser-383 in the PC1 protein and at Asp-167, His-208, and Ser-384 in the PC2 protein.	Histidine	89-92	proprotein convertase subtilisin/kexin type 1	Homo sapiens	117-120
8463315-5	1993	The role of this site in catalysis was examined by mutating one of the presumptive Zn(2+)-coordinating histidines (His108) in human insulin-degrading enzyme to leucine or glutamine, which were predicted to reduce or eliminate Zn2+ binding without substantially altering secondary structure.	Histidine	103-113	insulin degrading enzyme	Homo sapiens	132-156
8496014-1	1993	Bombesin (Bn, pGlu-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2) is one of the most potent peptides, possessing a variety of physiological and pharmacological functions.	Histidine	59-62	gastrin releasing peptide	Homo sapiens	0-8
30335580-1	2018	Carnosine and anserine are dipeptides synthesized from histidine and beta-alanine by carnosine synthase (ATPGD1).	Histidine	55-64	carnosine synthase 1	Homo sapiens	105-111
30012884-5	2018	Substitution of this histidine, and the consequent decreases in GAPDH heme binding, antagonized heme delivery to both cytosolic and nuclear hemeprotein targets, including inducible nitric-oxide synthase (iNOS) in murine macrophages and the nuclear transcription factor Hap1 in yeast, even though this GAPDH variant caused cellular levels of labile heme to rise dramatically.	Histidine	21-30	glyceraldehyde-3-phosphate dehydrogenase	Mus musculus	64-69
12865089-8	2003	These results imply that following repeated L-histidine administration in the rat (1) there is enhanced synthesis of brain histamine not reflected in its functional release; (2) the excess of histamine is sequestered and stored rather than being metabolized; (3) histamine H(3) receptor binding properties are not altered, whereas receptor density is changed in selected regions.	Histidine	44-55	histamine receptor H3	Rattus norvegicus	263-286
8445019-4	1993	A point mutation was discovered that changed codon 65 from arginine (CGT) to histidine (CAT) in one allele.	Histidine	77-86	UDP glycosyltransferase 8	Homo sapiens	69-72
12878219-2	2003	Structural and functional studies have shown that the NAT1 and factor XIII transglutaminase catalytic pockets are structurally related with the existence of a conserved catalytic triad (Cys-His-Asp).	Histidine	190-193	N-acetyltransferase 1	Homo sapiens	54-58
8447816-0	1993	Histidine residues are essential for the surface binding and autoactivation of human coagulation factor XII.	Histidine	0-9	coagulation factor XII	Homo sapiens	85-107
8431430-0	1993	Engineering the zinc binding site of human carbonic anhydrase II: structure of the His-94--&gt;Cys apoenzyme in a new crystalline form.	Histidine	83-86	carbonic anhydrase 2	Homo sapiens	43-64
8431430-1	1993	The structure of the His-94--&gt;Cys variant of human carbonic anhydrase II (CAII) has been determined by X-ray crystallographic methods to a resolution of 2.3 A with a final crystallographic R factor of 0.155.	Histidine	21-24	carbonic anhydrase 2	Homo sapiens	54-75
29936834-0	2018	Identification of the Histidine Residue in Vitamin D Receptor That Covalently Binds to Electrophilic Ligands.	Histidine	22-31	vitamin D receptor	Homo sapiens	43-61
8431430-1	1993	The structure of the His-94--&gt;Cys variant of human carbonic anhydrase II (CAII) has been determined by X-ray crystallographic methods to a resolution of 2.3 A with a final crystallographic R factor of 0.155.	Histidine	21-24	carbonic anhydrase 2	Homo sapiens	77-81
30029625-8	2018	RESULTS: A novel mutation in the FOXL2 gene (c.931C &gt; T) was detected in all five BPES patients, which converts a histidine residue into a tyrosine (p.H311Y) in the FOXL2 protein.	Histidine	117-126	forkhead box L2	Homo sapiens	33-38
8431430-7	1993	Spectroscopic analysis of Co(2+)-substituted His-94--&gt;Cys CAII indicates that the metal binds in a tetrahedral geometry with a new thiolate bond.	Histidine	45-48	carbonic anhydrase 2	Homo sapiens	61-65
30029625-8	2018	RESULTS: A novel mutation in the FOXL2 gene (c.931C &gt; T) was detected in all five BPES patients, which converts a histidine residue into a tyrosine (p.H311Y) in the FOXL2 protein.	Histidine	117-126	forkhead box L2	Homo sapiens	168-173
15969068-2	2003	The cDNA of human leptin with 6 x his-tag was cloned by over-hang extension PCR protocol using human genomic DNA as template, and subcloned into in vitro expression vector pIVEX2.3MCS, and the fusion protein was expressed in vitro by Rapid Translation System (RTS) (RTS500 cycle primer Kit and RTS500 ProteoMaster of Roche company).	Histidine	34-37	leptin	Homo sapiens	18-24
30069489-3	2018	SLC15A3, a proton-coupled histidine and di-tripeptide transporter that was previously found in lysosomes, has been reported to inhibit chikungunya viral replication in host cells.	Histidine	26-35	solute carrier family 15 member 3	Homo sapiens	0-7
8096552-7	1993	Comparison of the amino acid residues of DRB1 chain suggested that the basic amino acid at position 13, which is present only on the DR2 and DR4 B1 molecules (Arg on DR2 and His on DR4), contributes to the susceptibility to autoimmune hepatitis among Japanese.	Histidine	174-177	major histocompatibility complex, class II, DR beta 4	Homo sapiens	141-144
8096552-7	1993	Comparison of the amino acid residues of DRB1 chain suggested that the basic amino acid at position 13, which is present only on the DR2 and DR4 B1 molecules (Arg on DR2 and His on DR4), contributes to the susceptibility to autoimmune hepatitis among Japanese.	Histidine	174-177	major histocompatibility complex, class II, DR beta 4	Homo sapiens	181-184
12672824-1	2003	Human, microsomal, and glutathione-dependent prostaglandin (PG) E synthase-1 (mPGES-1) was expressed with a histidine tag in Escherichia coli.	Histidine	108-117	prostaglandin E synthase	Mus musculus	78-85
1334481-0	1992	Conversion of the proximal histidine ligand to glutamine restores activity to an inactive mutant of cytochrome c peroxidase.	Histidine	27-36	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	100-123
1492975-4	1992	In this report a comparison of CH3O-Suc-Ala-Ala-Pro-Val-CH2Cl-inhibited elastase with HBP, its naturally occurring homologue selectively mutated in active serine and histidine, reveals that homotypic aggregation of monocytes and contraction of fibroblasts is specific for HBP.	Histidine	166-175	azurocidin 1	Homo sapiens	86-89
12578831-2	2003	Exposure of this histidine in antithrombin, which has a partially opened sheet, allows polymerization and peptide insertion to occur at pH 6 or less when His-334 will be predictably protonated with disruption of the H-bond network.	Histidine	17-26	serpin family C member 1	Homo sapiens	30-42
1491459-7	1992	3) Analysis of carbonic anhydrase II (CA II) gene in a Belgian family with renal tubular acidosis associated with osteoporosis and cerebral calcification has shown a point mutation replacing an invariant histidine residue of CA II protein with tyrosine.	Histidine	204-213	carbonic anhydrase 2	Homo sapiens	15-36
1491459-7	1992	3) Analysis of carbonic anhydrase II (CA II) gene in a Belgian family with renal tubular acidosis associated with osteoporosis and cerebral calcification has shown a point mutation replacing an invariant histidine residue of CA II protein with tyrosine.	Histidine	204-213	carbonic anhydrase 2	Homo sapiens	38-43
1491459-7	1992	3) Analysis of carbonic anhydrase II (CA II) gene in a Belgian family with renal tubular acidosis associated with osteoporosis and cerebral calcification has shown a point mutation replacing an invariant histidine residue of CA II protein with tyrosine.	Histidine	204-213	carbonic anhydrase 2	Homo sapiens	225-230
12578831-2	2003	Exposure of this histidine in antithrombin, which has a partially opened sheet, allows polymerization and peptide insertion to occur at pH 6 or less when His-334 will be predictably protonated with disruption of the H-bond network.	Histidine	154-157	serpin family C member 1	Homo sapiens	30-42
12578831-3	2003	Similarly, thermal stability of antithrombin is pH-dependent with a single unfolding transition at pH 6, but there is no such transition when His-334 is buried by a fully closed A-sheet in heparin-complexed antithrombin or in alpha(1)-antitrypsin.	Histidine	142-145	serpin family C member 1	Homo sapiens	32-44
12578831-4	2003	Replacement of His-334 in alpha(1)-antitrypsin by a serine or alanine at pH 7.4 results in the same polymerization and loop-peptide acceptance observed with antithrombin at low pH.	Histidine	15-18	serpin family C member 1	Homo sapiens	157-169
1385407-5	1992	Conservative substitutions of 2 highly conserved basic residues in the SH2-N domain, an arginine and a histidine, resulted in complete loss of receptor and p62 binding, whereas other basic residues, and residues at variable SH2 sites, were more tolerant of substitution.	Histidine	103-112	nucleoporin 62	Homo sapiens	156-159
12699701-3	2003	The E1alpha sequence was engineered to include an N-terminal His-tag.	Histidine	61-64	pyruvate dehydrogenase complex E1 alpha subunit	Arabidopsis thaliana	4-11
1359165-4	1992	The increased HLA-DQB1 alleles have a histidine residue in common at the 30th codon for the HLA-DQ beta chain.	Histidine	38-47	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	14-22
1359165-4	1992	The increased HLA-DQB1 alleles have a histidine residue in common at the 30th codon for the HLA-DQ beta chain.	Histidine	38-47	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	14-17
12804117-1	2003	TGFbeta-Inducible Early Gene (TIEG) and the alternatively-transcribed Early Growth Response Gene alpha (EGRalpha) share a Cys(2)His(2) three-zinc finger region with high homology to Sp1 within its zinc finger region.	Histidine	128-131	Kruppel like factor 10	Homo sapiens	0-28
1324923-5	1992	Mutant receptors with the carboxyl-terminal His-Leu-Leu-Pro-Met67 residues deleted or replaced with alanines sorted cathepsin D below the base-line value.	Histidine	44-47	cathepsin D	Bos taurus	116-127
1324923-6	1992	A mutant receptor with the outermost Pro-Met residues replaced with alanines sorted cathepsin D better than the wild-type receptor, indicating that the essential residues for sorting are the His-Leu-Leu sequence.	Histidine	191-194	cathepsin D	Bos taurus	84-95
1354487-0	1992	Proton transfer roles of lysine 64 and glutamic acid 64 replacing histidine 64 in the active site of human carbonic anhydrase II.	Histidine	66-75	carbonic anhydrase 2	Homo sapiens	107-128
12804117-1	2003	TGFbeta-Inducible Early Gene (TIEG) and the alternatively-transcribed Early Growth Response Gene alpha (EGRalpha) share a Cys(2)His(2) three-zinc finger region with high homology to Sp1 within its zinc finger region.	Histidine	128-131	Kruppel like factor 10	Homo sapiens	30-34
12610214-0	2003	In vivo and in vitro characterization of the ARR11 response regulator implicated in the His-to-Asp phosphorelay signal transduction in Arabidopsis thaliana.	Histidine	88-91	response regulator 11	Arabidopsis thaliana	45-50
1535355-5	1992	The kallikrein cleavage points that provided 112 kd and 102 kd two-chain high molecular weight kininogen were after residues 437 (Arg-Lys) and 389 (Arg-Ser), whereas those for plasmin were after 438 (Lys-His) and 389 (Arg-Ser).	Histidine	204-207	kallikrein related peptidase 4	Homo sapiens	4-14
12610214-6	2003	In vitro, ARR11 showed the ability to acquire a phosphoryl group from a histidine-containing phosphotransfer intermediate (AHP), and also it showed the ability to recognize a specific nucleotide sequence, GGATT.	Histidine	72-81	response regulator 11	Arabidopsis thaliana	10-15
12493540-4	2003	Human LAT1-mediated [(125)I]IMT uptake was highly stereoselective for the L-isomers of Tyr, His, Trp, Val and Ileu.	Histidine	92-95	solute carrier family 7 member 5	Homo sapiens	6-10
16668921-6	1992	The smaller extensin monomer reported here (Superose-6 peak 2 [SP2]) was compositionally similar to typical dicot extensins such as tomato P1, mainly consisting of Hyp, Thr, Ser, Pro, Val, Tyr, Lys, His, abundant arabinose, and a small but significant galactose content.	Histidine	199-202	extensin-3-like	Solanum lycopersicum	12-20
12213808-8	2002	Finally, AMPD1 and a series of N-truncated AMPD3 enzymes are used to show that these behaviors are specific to isoform E and require up to 48 N-terminal amino acids, even though this stretch of sequence contains no histidine residues.	Histidine	215-224	adenosine monophosphate deaminase 1	Homo sapiens	9-14
1599941-1	1992	The reversible intramolecular binding of the distal histidine side chain to the heme iron in methemoglobin is of special interest due to the very large negative reaction entropy which overcompensates the large reaction enthalpy.	Histidine	52-61	hemoglobin subunit gamma 2	Homo sapiens	93-106
12194980-7	2002	Studies with recombinant V5-His-tagged FLRG protein confirm a direct interaction between mature myostatin and FLRG.	Histidine	28-31	myostatin	Mus musculus	96-105
1544468-7	1992	The results obtained for human pancreatic lipase corroborate the inhibition mechanism of THL found on the porcine enzyme, and are in full agreement with the identification of the Ser-152 ... His-263 ... Asp-176 catalytic triad in the X-ray structure of human pancreatic lipase.	Histidine	191-194	pancreatic lipase	Homo sapiens	31-48
1544468-7	1992	The results obtained for human pancreatic lipase corroborate the inhibition mechanism of THL found on the porcine enzyme, and are in full agreement with the identification of the Ser-152 ... His-263 ... Asp-176 catalytic triad in the X-ray structure of human pancreatic lipase.	Histidine	191-194	pancreatic lipase	Homo sapiens	259-276
12459266-5	2002	The presence of this motif, together with a conserved order and spacing of the Ser, Asp, and His residues that form the catalytic triad in DPP IV, places DPP9 in the "DPP IV gene family".	Histidine	93-96	dipeptidyl peptidase 4	Homo sapiens	139-145
12145299-3	2002	Pho2 + Swi5 activates HO, Pho2 + Pho4 activates PHO5, and Pho2 + Bas1 activates genes in the purine and histidine biosynthesis pathways.	Histidine	104-113	Pho2p	Saccharomyces cerevisiae S288C	0-4
12145299-3	2002	Pho2 + Swi5 activates HO, Pho2 + Pho4 activates PHO5, and Pho2 + Bas1 activates genes in the purine and histidine biosynthesis pathways.	Histidine	104-113	Pho2p	Saccharomyces cerevisiae S288C	26-30
12145299-3	2002	Pho2 + Swi5 activates HO, Pho2 + Pho4 activates PHO5, and Pho2 + Bas1 activates genes in the purine and histidine biosynthesis pathways.	Histidine	104-113	Pho2p	Saccharomyces cerevisiae S288C	26-30
27286379-5	1992	On the other hand, pancreatic lipase activity was stimulated by not only BSA, but L-histidine and L-aspartic acid as N-end amino groups of BSA and additionally accelerated it in combination with bile salts.	Histidine	82-93	pancreatic lipase	Homo sapiens	19-36
12366840-5	2002	In fact, using histidine tagging, the existence of a suppressed Cox14p of normal length was demonstrated in mutants expressing the mt-tRNAVAL from the nucleus.	Histidine	15-24	Cox14p	Saccharomyces cerevisiae S288C	64-70
1350267-5	1992	These findings suggest that the DR4-specific sequence (Val 11 and His 13 at amino acid positions 11 and 13, respectively), but not particular Dw-associated DR4 sequence, in the first domain of the DRB1 chain contributes to susceptibility to autoimmune hepatitis among Japanese.	Histidine	66-69	major histocompatibility complex, class II, DR beta 4	Homo sapiens	32-35
1350267-7	1992	Taken together, these results imply that the basic amino acids at position 13, which is present only on the DR2 and DR4 B1 molecules (Arg on DR2 and His on DR4), are most important for determining the predisposition to autoimmune hepatitis.	Histidine	149-152	major histocompatibility complex, class II, DR beta 4	Homo sapiens	116-119
1350267-7	1992	Taken together, these results imply that the basic amino acids at position 13, which is present only on the DR2 and DR4 B1 molecules (Arg on DR2 and His on DR4), are most important for determining the predisposition to autoimmune hepatitis.	Histidine	149-152	major histocompatibility complex, class II, DR beta 4	Homo sapiens	156-159
12107175-10	2002	Alanine-scanning mutagenesis of residues 105-117 within glutathione S-transferase (GST)-AbetaPP-(18-119) revealed that His(110), Val(112), and Ile(113) are key residues that facilitate AbetaPP binding to fibrillar Abeta.	Histidine	119-122	glutathione S-transferase kappa 1	Homo sapiens	56-81
1928091-0	1991	Carbonic anhydrase II deficiency syndrome in a Belgian family is caused by a point mutation at an invariant histidine residue (107 His----Tyr): complete structure of the normal human CA II gene.	Histidine	108-117	carbonic anhydrase 2	Homo sapiens	183-188
1928091-5	1991	His-107 appears to have a stabilizing function in the structure of all CA molecules, and its substitution by Tyr apparently disrupts the critical hydrogen bonding of His-107 to two other similarly invariant residues, Glu-117 and Tyr-194, resulting in an unstable CA II molecule.	Histidine	0-3	carbonic anhydrase 2	Homo sapiens	263-268
1928091-5	1991	His-107 appears to have a stabilizing function in the structure of all CA molecules, and its substitution by Tyr apparently disrupts the critical hydrogen bonding of His-107 to two other similarly invariant residues, Glu-117 and Tyr-194, resulting in an unstable CA II molecule.	Histidine	166-169	carbonic anhydrase 2	Homo sapiens	263-268
1716370-0	1991	The peptide Glu-His-Ile-Pro-Ala binds fibrinogen and inhibits platelet aggregation and adhesion to fibrinogen and vitronectin.	Histidine	16-19	vitronectin	Homo sapiens	114-125
1883837-4	1991	The Dromsopa opa repeat codes for the usual stretch of poly(glutamine) interrupted by histidine residues.	Histidine	86-95	male-specific opa containing gene	Drosophila melanogaster	4-12
12107175-10	2002	Alanine-scanning mutagenesis of residues 105-117 within glutathione S-transferase (GST)-AbetaPP-(18-119) revealed that His(110), Val(112), and Ile(113) are key residues that facilitate AbetaPP binding to fibrillar Abeta.	Histidine	119-122	glutathione S-transferase kappa 1	Homo sapiens	83-86
12124384-2	2002	Using recombinant human wild type and mutant MBD3 proteins, we demonstrated that atypical amino acids found in MBD3 MBD, namely, His-30 and Phe-34, are responsible for the inability of MBD3 to bind to mCpG.	Histidine	129-132	methyl-CpG binding domain protein 3	Homo sapiens	45-49
1831223-12	1991	When a histidine residue is present at this amino acid position, hIgG2 dimers do bind efficiently to Fc gamma RII, whereas mIgG1-sensitized E and mAb 41H16 exhibit a strongly diminished binding.	Histidine	7-16	LOC105243590	Mus musculus	123-128
12124384-2	2002	Using recombinant human wild type and mutant MBD3 proteins, we demonstrated that atypical amino acids found in MBD3 MBD, namely, His-30 and Phe-34, are responsible for the inability of MBD3 to bind to mCpG.	Histidine	129-132	methyl-CpG binding domain protein 3	Homo sapiens	111-115
1677358-6	1991	In one out of the five subjects with the apoA-IV-1/0 phenotype we identified two point mutations: 1) replacing the positively charged lysine (AAG), amino acid 167, with a negatively charged glutamic acid (GAG), and 2) converting the neutral residue 360, glutamine (CAG), to a positively charged histidine (CAT).	Histidine	295-304	N-methylpurine DNA glycosylase	Homo sapiens	142-145
12124384-2	2002	Using recombinant human wild type and mutant MBD3 proteins, we demonstrated that atypical amino acids found in MBD3 MBD, namely, His-30 and Phe-34, are responsible for the inability of MBD3 to bind to mCpG.	Histidine	129-132	methyl-CpG binding domain protein 3	Homo sapiens	111-115
12207908-6	2002	It was suggested that the polymerization of Fas antigen, which was the essential process for the efficient induction of apoptosis, was interfered by the alteration of CRD1, and that this portion, named the "histidine-rich region," played a critical role in Fas assembly.	Histidine	207-216	Fas cell surface death receptor	Homo sapiens	44-55
1799700-6	1991	The phenotype of the virA112 mutant resulted from a glycine to glutamic acid change near His-474, the site of VirA autophosphorylation.	Histidine	89-92	two-component VirA-like sensor kinase	Agrobacterium tumefaciens	110-114
12183328-0	2002	An N-terminal histidine regulates Zn(2+) inhibition on the murine GABA(A) receptor beta3 subunit.	Histidine	14-23	gamma-aminobutyric acid (GABA) A receptor, subunit beta 3	Mus musculus	83-88
2049091-6	1991	However, azurocidin has Gly for Ser and Ser for His substitutions in the catalytic triad.	Histidine	48-51	azurocidin 1	Homo sapiens	9-19
12183328-11	2002	External histidine residues in the beta3 receptor subunit were substituted with alanine, in addition to the background mutation, H267A, to assess their sensitivity to Zn(2+) inhibition.	Histidine	9-18	gamma-aminobutyric acid (GABA) A receptor, subunit beta 3	Mus musculus	35-40
12385583-10	2002	In the present study, mutation of the p53 gene was detected in three DMBA-induced leukemias as follows: a single-base substitution (CAT to CGT) at codon 177 (exon 5), resulting in an amino-acid change from Arg to Leu, a CGG to CTG/CGG changed at codon 211 (exon 6) resulting in an amino-acid change from His to Arg/His, and a GGG to TGG at codon 242 (exon 6) resulting in an amino-acid change from Gly to Trp, respectively.	Histidine	304-307	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	38-41
1851482-2	1991	A derivative with histidines selectively deuteriated in the C2 position has been used for the detection of the HC2 histidine protons, 16 out of 17 observed signals of the 18 active-site histidine ring protons have been assigned.	Histidine	18-28	CYCS pseudogene 38	Homo sapiens	111-114
1851482-2	1991	A derivative with histidines selectively deuteriated in the C2 position has been used for the detection of the HC2 histidine protons, 16 out of 17 observed signals of the 18 active-site histidine ring protons have been assigned.	Histidine	18-27	CYCS pseudogene 38	Homo sapiens	111-114
1851482-2	1991	A derivative with histidines selectively deuteriated in the C2 position has been used for the detection of the HC2 histidine protons, 16 out of 17 observed signals of the 18 active-site histidine ring protons have been assigned.	Histidine	115-124	CYCS pseudogene 38	Homo sapiens	111-114
12385583-10	2002	In the present study, mutation of the p53 gene was detected in three DMBA-induced leukemias as follows: a single-base substitution (CAT to CGT) at codon 177 (exon 5), resulting in an amino-acid change from Arg to Leu, a CGG to CTG/CGG changed at codon 211 (exon 6) resulting in an amino-acid change from His to Arg/His, and a GGG to TGG at codon 242 (exon 6) resulting in an amino-acid change from Gly to Trp, respectively.	Histidine	315-318	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	38-41
12161265-2	2002	Binding of [His(1), (125)I-Tyr(10), Nle(27)]hGHRH(1-32) amide and GHRH receptor (GHRH-R) mRNA levels were determined in the hypothalamus and pituitary of rats subjected to 8 h of SD and of undisturbed control rats.	Histidine	12-15	growth hormone releasing hormone receptor	Rattus norvegicus	66-79
1850190-5	1991	Comparative peptide mapping, by HPLC, of the acidic variant carriers and of normal TTR showed the presence of an abnormal tryptic peptide, not present in the normal TTR digests, with an asparagine-for-histidine substitution at position 90 explained by a single base change of adenine for cytosine in the histidine codon.	Histidine	201-210	transthyretin	Homo sapiens	83-86
12161265-2	2002	Binding of [His(1), (125)I-Tyr(10), Nle(27)]hGHRH(1-32) amide and GHRH receptor (GHRH-R) mRNA levels were determined in the hypothalamus and pituitary of rats subjected to 8 h of SD and of undisturbed control rats.	Histidine	12-15	growth hormone releasing hormone receptor	Rattus norvegicus	81-87
12167006-3	2002	It is shown that the specific hydrogen bond between His(101H) and Man C-4 OH is preserved in the gaseous complex.	Histidine	52-55	complement C4A (Rodgers blood group)	Homo sapiens	70-73
2043465-8	1991	Following polymerase chain reaction (PCR) amplification, cloning and sequencing of exon 2 of spectrin alpha-gene in the father, we found the G----A substitution at position 2 of codon 22 (CGT----CAT; Arg----His).	Histidine	207-210	UDP glycosyltransferase 8	Homo sapiens	188-191
12167017-2	2002	We engineered a novel protein, "Antennafinger (Ant-F)", whose structure and function can be controlled with Zn(II), by introducing the consensus sequence of a Cys(2)His(2)-type zinc finger protein into a non-metalloprotein scaffold, an Antennapedia homeodomain mutant (Ant-wt), selected using a motif-searching system.	Histidine	165-168	solute carrier family 25 member 6	Homo sapiens	32-35
2005112-2	1991	E2 and E3 are synthesized as a precursor, p62, which is cleaved post-translationally after an Arg-His-Arg-Arg sequence.	Histidine	98-101	nucleoporin 62	Homo sapiens	42-45
12167017-2	2002	We engineered a novel protein, "Antennafinger (Ant-F)", whose structure and function can be controlled with Zn(II), by introducing the consensus sequence of a Cys(2)His(2)-type zinc finger protein into a non-metalloprotein scaffold, an Antennapedia homeodomain mutant (Ant-wt), selected using a motif-searching system.	Histidine	165-168	solute carrier family 25 member 6	Homo sapiens	47-50
1999399-0	1991	Site-specific mutagenesis of an essential histidine residue in pancreatic cholesterol esterase.	Histidine	42-51	carboxyl ester lipase	Rattus norvegicus	63-94
12167017-4	2002	The optical absorption spectra of the Co(II) complexes of Ant-F and its derivative proteins suggest that the geometry of the metal center of holo-Ant-F is tetrahedral and that the mutated Cys(2)His(2) residues are involved in the complex formation.	Histidine	194-197	solute carrier family 25 member 6	Homo sapiens	58-61
1999399-1	1991	The histidine residue essential for the catalytic activity of pancreatic cholesterol esterase (carboxylester lipase) has been identified in this study using sequence comparison and site-specific mutagenesis techniques.	Histidine	4-13	carboxyl ester lipase	Rattus norvegicus	62-93
1999399-1	1991	The histidine residue essential for the catalytic activity of pancreatic cholesterol esterase (carboxylester lipase) has been identified in this study using sequence comparison and site-specific mutagenesis techniques.	Histidine	4-13	carboxyl ester lipase	Rattus norvegicus	95-115
1999399-2	1991	In the first approach, comparison of the primary structure of rat pancreatic cholesterol esterase with that of acetylcholinesterase and cholinesterase revealed two conserved histidine residues located at positions 420 and 435.	Histidine	174-183	carboxyl ester lipase	Rattus norvegicus	66-97
12145341-7	2002	Conversely, the substitution of Y614 of the rFSHR with the cognate hFSHR residue (histidine) fully suppresses the constitutive activity of the rFSHR (D580G) mutant.	Histidine	82-91	follicle stimulating hormone receptor	Rattus norvegicus	44-49
1999399-2	1991	In the first approach, comparison of the primary structure of rat pancreatic cholesterol esterase with that of acetylcholinesterase and cholinesterase revealed two conserved histidine residues located at positions 420 and 435.	Histidine	174-183	butyrylcholinesterase	Rattus norvegicus	117-131
1999399-5	1991	Based on this sequence homology, it was hypothesized that histidine 435 is the histidine residue essential for catalytic activity of cholesterol esterase.	Histidine	58-67	carboxyl ester lipase	Rattus norvegicus	133-153
1999399-5	1991	Based on this sequence homology, it was hypothesized that histidine 435 is the histidine residue essential for catalytic activity of cholesterol esterase.	Histidine	79-88	carboxyl ester lipase	Rattus norvegicus	133-153
1999399-9	1991	The results of this study strongly suggested that histidine 435 may be a component of the catalytic triad of pancreatic cholesterol esterase.	Histidine	50-59	carboxyl ester lipase	Rattus norvegicus	109-140
12145341-7	2002	Conversely, the substitution of Y614 of the rFSHR with the cognate hFSHR residue (histidine) fully suppresses the constitutive activity of the rFSHR (D580G) mutant.	Histidine	82-91	follicle stimulating hormone receptor	Rattus norvegicus	143-148
11953431-7	2002	Two sequence motifs are found in common between human gamma-glutamyl hydrolase and the class I glutamine amidotransferase family and include the catalytically essential residues, Cys-110 and His-220.	Histidine	191-194	gamma-glutamyl hydrolase	Homo sapiens	54-78
1996120-0	1991	The TIS11 primary response gene is a member of a gene family that encodes proteins with a highly conserved sequence containing an unusual Cys-His repeat.	Histidine	142-145	zinc finger protein 36	Rattus norvegicus	4-9
12137948-6	2002	Four alleles of dMi-2 mutants were further characterized in molecular nature; dMi-2(BL1) was found to have a mutation in the ATP-binding motif of the ATPase domain, dMi-2(BL7) in the core histidine of the first plant homeodomain zinc finger and dMi-2(BL12) in a conserved serine in the chromodomain.	Histidine	188-197	Mi-2	Drosophila melanogaster	16-21
1998686-8	1991	Potential catalytic roles are assigned to the conserved His 214, Cys 262, Asp 295, and Asp 296 residues of mammalian adenosine deaminases and the corresponding conserved amino acid residues in bacterial adenosine deaminase and the eukaryotic AMP deaminases.	Histidine	56-59	adenosine deaminase	Homo sapiens	117-136
12137948-6	2002	Four alleles of dMi-2 mutants were further characterized in molecular nature; dMi-2(BL1) was found to have a mutation in the ATP-binding motif of the ATPase domain, dMi-2(BL7) in the core histidine of the first plant homeodomain zinc finger and dMi-2(BL12) in a conserved serine in the chromodomain.	Histidine	188-197	Mi-2	Drosophila melanogaster	78-83
12137948-6	2002	Four alleles of dMi-2 mutants were further characterized in molecular nature; dMi-2(BL1) was found to have a mutation in the ATP-binding motif of the ATPase domain, dMi-2(BL7) in the core histidine of the first plant homeodomain zinc finger and dMi-2(BL12) in a conserved serine in the chromodomain.	Histidine	188-197	Mi-2	Drosophila melanogaster	78-83
1988069-4	1991	The amino-terminal domain of rat hemopexin contains two histidine residues that are conserved in the human and rat sequences and are the most likely heme axial ligands.	Histidine	56-65	hemopexin	Rattus norvegicus	33-42
12137948-6	2002	Four alleles of dMi-2 mutants were further characterized in molecular nature; dMi-2(BL1) was found to have a mutation in the ATP-binding motif of the ATPase domain, dMi-2(BL7) in the core histidine of the first plant homeodomain zinc finger and dMi-2(BL12) in a conserved serine in the chromodomain.	Histidine	188-197	Mi-2	Drosophila melanogaster	78-83
12065401-3	2002	The binding pocket of ABP1 is predominantly hydrophobic with a metal ion deep inside the pocket coordinated by three histidines and a glutamate.	Histidine	117-127	auxin-binding protein 1	Zea mays	22-26
1824702-0	1991	Disruption of an ATP-dependent isomerization of the recA protein by mutation of histidine 163.	Histidine	80-89	RAD51 recombinase	Homo sapiens	52-56
1824702-1	1991	We have used site-directed mutagenesis to replace histidine 163 of the recA polypeptide with an alanine residue.	Histidine	50-59	RAD51 recombinase	Homo sapiens	71-75
11919192-4	2002	Inhibition of caspase-9 with either the peptide inhibitor benzyloxycarbonyl-Leu-Glu(OCH(3))-His-Asp(OCH(3))-fluoromethyl ketone, or expression of a catalytically inactive caspase-9 by retroviral transduction, protected normal keratinocytes from UV-induced apoptosis.	Histidine	92-95	caspase 9	Homo sapiens	14-23
1983814-10	1991	However, iron chelates of ascorbate, fructose, and histidine donated iron to mucin at neutral pH.	Histidine	51-60	solute carrier family 13 member 2	Rattus norvegicus	77-82
12022880-6	2002	This study establishes the structure of the Ni site in resting Ni-ARD as containing a six coordinate Ni site composed of O/N-donor ligands including 3-4 histidine residues, demonstrates that the substrate binds to the Ni center in a bidentate fashion by displacing two ligands, at least one of which is a histidine ligand, and provides insight into the mechanism of catalysis employed by a Ni-containing dioxygenase.	Histidine	153-162	acireductone dioxygenase 1	Homo sapiens	63-69
12022880-6	2002	This study establishes the structure of the Ni site in resting Ni-ARD as containing a six coordinate Ni site composed of O/N-donor ligands including 3-4 histidine residues, demonstrates that the substrate binds to the Ni center in a bidentate fashion by displacing two ligands, at least one of which is a histidine ligand, and provides insight into the mechanism of catalysis employed by a Ni-containing dioxygenase.	Histidine	305-314	acireductone dioxygenase 1	Homo sapiens	63-69
1979919-7	1990	Modification of brush border membrane vesicles with the histidine-modifying reagent diethyl pyrocarbonate led to a strong irreversible inhibition of cephalexin uptake whereas the activity of aminopeptidase N remained unchanged.	Histidine	56-65	alanyl aminopeptidase, membrane	Sus scrofa	191-207
11988102-6	2002	We took advantage of the functionality of the purified material to (i) develop an efficient surface-plasmon resonance assay of the interaction between two calcium channel subunits and (ii) measure, for the first time, the affinity of the recombinant His-beta(4) subunit for the full-length Ca(v)2.1 channel.	Histidine	250-253	basic helix-loop-helix family member e23 L homeolog	Xenopus laevis	254-261
2174256-0	1990	Multiple heme pocket subconformations of methemoglobin associated with distal histidine interactions.	Histidine	78-87	hemoglobin subunit gamma 2	Homo sapiens	41-54
2174256-1	1990	Electron paramagnetic resonance spectra of methemoglobin reveal that, in addition to the major tetragonal high-spin aqueous complex and the low-spin hydroxide complex, three other complexes associated with the interaction of the distal histidine are resolved.	Histidine	236-245	hemoglobin subunit gamma 2	Homo sapiens	43-56
12054542-1	2002	Arabidopsis ARR4/ATRR1/IBC7 and ARR8/ATRR3 are homologous genes of prokaryotic response regulators that are involved in the His-Asp phosphorelay signal transduction.	Histidine	124-127	response regulator 4	Arabidopsis thaliana	12-16
1696877-4	1990	His-151 and Met-170 were placed in epitopes NA71 and AC8, respectively, whereas His-18 and Met-14 would be involved in the hGH antigenic domain formed by overlapping epitopes 3C11, 10C1, and HG3.	Histidine	0-3	adenylate cyclase 8	Homo sapiens	53-56
2118103-0	1990	The molecular characterization of PRP6 and PRP9 yeast genes reveals a new cysteine/histidine motif common to several splicing factors.	Histidine	83-92	SF3a splicing factor complex subunit PRP9	Saccharomyces cerevisiae S288C	43-47
12054542-1	2002	Arabidopsis ARR4/ATRR1/IBC7 and ARR8/ATRR3 are homologous genes of prokaryotic response regulators that are involved in the His-Asp phosphorelay signal transduction.	Histidine	124-127	response regulator 4	Arabidopsis thaliana	17-22
2118103-6	1990	Both PRP6 and PRP9 proteins have cysteine/histidine motifs loosely related to those found in zinc finger proteins.	Histidine	42-51	SF3a splicing factor complex subunit PRP9	Saccharomyces cerevisiae S288C	14-18
12054542-1	2002	Arabidopsis ARR4/ATRR1/IBC7 and ARR8/ATRR3 are homologous genes of prokaryotic response regulators that are involved in the His-Asp phosphorelay signal transduction.	Histidine	124-127	response regulator 4	Arabidopsis thaliana	23-27
11985867-2	2002	TCTP genes from B. malayi and W. bancrofti were expressed in a T7 promoter vector as histidine tagged fusion proteins.	Histidine	85-94	tumor protein, translationally-controlled 1	Homo sapiens	0-4
2196279-4	1990	By directly sequencing genomic DNA amplified by polymerase chain reaction, we have demonstrated that both patients are heterozygous for the same point mutation converting codon 65 from an arginine (CGT) to a histidine (CAT) codon.	Histidine	208-217	UDP glycosyltransferase 8	Homo sapiens	198-201
2328319-10	1990	We found a G to A base substitution in the 22nd codon (CAT for CGT), which changes the normal arginine to a histidine.	Histidine	108-117	UDP glycosyltransferase 8	Homo sapiens	63-66
11985867-3	2002	Both the recombinant B. malayi TCTP (rBm-TCTP) and recombinant W. bancrofti TCTP (rWb-TCTP) have a molecular mass of approximately 28 kDa with the histidine tag.	Histidine	147-156	tumor protein, translationally-controlled 1	Homo sapiens	31-35
11856731-2	2002	In particular, three amino acids that stabilize the transition state for the activation of tyrosine in B. stearothermophilus tyrosyl-tRNA synthetase (Cys-35, His-48, and Lys-233) are not present in the human enzyme.	Histidine	158-161	tyrosyl-tRNA synthetase 1	Homo sapiens	125-148
2347667-8	1990	These experiments evaluated the effectiveness of encapsulated histidase in depleting histidine.	Histidine	85-94	histidine ammonia-lyase	Homo sapiens	62-71
29653252-1	2018	The replacement of two consecutive histidine residues by alanine residues in the catalytic center of ceramide synthase 2 in a new transgenic mouse mutant (CerS2 H/A) leads to inactivation of catalytic activity and reduces protein level to 60% of the WT level.	Histidine	35-44	ceramide synthase 2	Mus musculus	101-120
29653252-1	2018	The replacement of two consecutive histidine residues by alanine residues in the catalytic center of ceramide synthase 2 in a new transgenic mouse mutant (CerS2 H/A) leads to inactivation of catalytic activity and reduces protein level to 60% of the WT level.	Histidine	35-44	ceramide synthase 2	Mus musculus	155-160
29696512-7	2018	Expression of PI3K-Akt-mTOR/JNK (24 h after HI or OGD/R) proteins was detected by Western blotting after stimulation with HI, NGR1, LY294002 (PI3K inhibitor), 740Y-P (PI3K agonist), or ICI 182780(estrogen receptors inhibitor).	Histidine	44-46	mechanistic target of rapamycin kinase	Rattus norvegicus	23-27
2404940-8	1990	When this histidine was changed to glutamine, which cannot be phosphorylated, the resulting VirA protein lost both its ability to autophosphorylate and its biological function as a vir gene regulator.	Histidine	10-19	two-component VirA-like sensor kinase	Agrobacterium tumefaciens	92-96
12419163-9	2002	In Western blot analysis, the single domain antibody from 2 of 4 clones proved to react with the His-tagged hTERT fusion protein (Mr = 167 000) without dependence of His-tags and also detect the native hTERT (Mr = 127 000) extracted from the human HeLa cancer cell line.	Histidine	97-100	telomerase reverse transcriptase	Homo sapiens	202-207
33973800-11	2021	Moreover, ClpP and its subunits may act downstream of the histidine utilization pathway, which could be inhibited by bismerthiazol in Xoo.	Histidine	58-67	clpP	Oryza sativa	10-14
11788601-6	2002	Spectral transformations observed for TC in the slow phase were similar to those upon histidine complexation with Cbl x OH(2) and Cbi.	Histidine	86-95	Cbl proto-oncogene	Homo sapiens	114-117
33796530-12	2021	LHPP-mediated histidine dephosphorylation lowered the expression levels of beta-catenin and the cell cycle-related genes CDK4 and CyclinD1, while it up-regulated the cell cycle suppressor genes P21 and P27.	Histidine	14-23	catenin (cadherin associated protein), beta 1	Mus musculus	75-87
33796530-12	2021	LHPP-mediated histidine dephosphorylation lowered the expression levels of beta-catenin and the cell cycle-related genes CDK4 and CyclinD1, while it up-regulated the cell cycle suppressor genes P21 and P27.	Histidine	14-23	cyclin D1	Mus musculus	130-138
33796530-14	2021	LHPP-mediated histidine dephosphorylation inhibited the self-renewal of ESCs by negatively regulating the Wnt/beta-catenin pathway and downstream cell cycle-related genes, providing a new perspective and regulatory target for ESCs self-renewal.	Histidine	14-23	catenin (cadherin associated protein), beta 1	Mus musculus	110-122
29366964-5	2018	cDNA fragments of human DLL1, encoding truncated versions of DLL1 with regions required to activate Notch receptors, were cloned and expressed as histidine-fused proteins in bacterial and mammalian cells.	Histidine	146-155	delta like canonical Notch ligand 1	Homo sapiens	24-28
29795045-6	2018	The residue that plays a major role in determining the diverse pKa values of the proton shuttle is the one in position four, namely His for hCA II and Gly for hCA VII.	Histidine	132-135	carbonic anhydrase 2	Homo sapiens	140-146
29795045-8	2018	These findings are in agreement with our previous studies that highlighted the importance of histidines on the protein surface of hCA II (among which His4) as crucial residues for the high catalytic efficiency of this isoform.	Histidine	93-103	carbonic anhydrase 2	Homo sapiens	130-136
8771178-1	1995	The structure of histidine 94--&gt;aspartate (H94D) carbonic anhydrase II (CAII) crystallized in an orthorhombic space group has been determined to 2.5 A resolution.	Histidine	17-26	carbonic anhydrase 2	Homo sapiens	52-73
8771178-1	1995	The structure of histidine 94--&gt;aspartate (H94D) carbonic anhydrase II (CAII) crystallized in an orthorhombic space group has been determined to 2.5 A resolution.	Histidine	17-26	carbonic anhydrase 2	Homo sapiens	75-79
11788601-10	2002	The above data suggest presence of a histidine-containing cap shielding the Cbl-binding site in TC.	Histidine	37-46	Cbl proto-oncogene	Homo sapiens	76-79
11756457-4	2002	Mutation of each of the two hERG1 histidines at positions 578 and 587 within the S(5)-S(6) linker generated K(+) channels insensitive to modulation by ROS.	Histidine	34-44	potassium voltage-gated channel subfamily H member 2	Homo sapiens	28-33
34979251-2	2022	We found an OBP sequence from the stable fly, Stomoxys calcitrans, ScalOBP60, that has a 25 amino acid N-terminal extension with a high content of histidine and acidic amino acids, suggesting a possible metal binding activity.	Histidine	147-156	Optix-binding protein	Drosophila melanogaster	12-15
29330883-5	2018	A high percentage of RERE pathogenic variants affect a histidine-rich region in the Atrophin-1 domain.	Histidine	55-64	arginine-glutamic acid dipeptide repeats	Homo sapiens	21-25
11756457-7	2002	Collectively, the results obtained suggest that histidines at positions 578 and 587 in the S(5)-S(6) linker region of hERG1 K(+) channels are crucial players in ROS-induced modulation of hERG1 K(+) channels.	Histidine	48-58	potassium voltage-gated channel subfamily H member 2	Homo sapiens	118-123
11756457-7	2002	Collectively, the results obtained suggest that histidines at positions 578 and 587 in the S(5)-S(6) linker region of hERG1 K(+) channels are crucial players in ROS-induced modulation of hERG1 K(+) channels.	Histidine	48-58	potassium voltage-gated channel subfamily H member 2	Homo sapiens	187-192
34948007-5	2021	The results provided the possibility to compare the Ni(II) binding properties between N-terminal and histidine-rich part of Hpn-like protein and between N-terminal parts of two Hpn-like strains, which differ mainly in the number of glutamine residues.	Histidine	101-110	hepsin	Homo sapiens	124-127
11884629-0	2002	Involvement of conserved histidine, lysine and tyrosine residues in the mechanism of DNA cleavage by the caspase-3 activated DNase CAD.	Histidine	25-34	DNA fragmentation factor, beta subunit	Mus musculus	131-134
29584404-5	2018	These advantages are demonstrated with the measurements of binding of acetazolamide (222.2 Da) to histidine-tagged human carbonic anhydrase II (his-tagged HCA).	Histidine	98-107	carbonic anhydrase 2	Homo sapiens	121-142
11866428-7	2002	Our data do not exclude, however, that the histidine sequence simply mimics the lysine motif as a sorting signal, being recognised by and interacting with the same receptor subunit(s) in COP-I-coated vesicles.	Histidine	43-52	caspase recruitment domain family member 16	Homo sapiens	187-190
29565811-5	2018	Biochemical analyses demonstrated that UK114 hydrolyzes alpha-imino acids generated by l- or d-amino acid oxidases with a preference for those deriving from Ala &gt; Leu = l-Met &gt; l-Gln, whereas it was poorly active on l-Phe and l-His.	Histidine	232-237	reactive intermediate imine deaminase A homolog	Homo sapiens	39-44
34218407-0	2021	METTL9 mediated N1-histidine methylation of zinc transporters is required for tumor growth.	Histidine	19-28	methyltransferase like 9	Homo sapiens	0-6
34782676-3	2021	EgtD, an S-adenosylmethionine-dependent methyltransferase (AdoMet), catalyzes the trimethylation of L-Histidine to initiate EGT biosynthesis and this reaction has been shown to be essential for EGT production in mycobacteria and for long-term infection of murine macrophages by M. tb.	Histidine	100-111	methionine adenosyltransferase I, alpha	Mus musculus	9-57
34782676-3	2021	EgtD, an S-adenosylmethionine-dependent methyltransferase (AdoMet), catalyzes the trimethylation of L-Histidine to initiate EGT biosynthesis and this reaction has been shown to be essential for EGT production in mycobacteria and for long-term infection of murine macrophages by M. tb.	Histidine	100-111	methionine adenosyltransferase I, alpha	Mus musculus	59-65
11741948-11	2002	By placing DEA into the active site of the open structure, the major forces to stabilize the closed conformation of AdoHcyase are identified as the hydrogen bonds between the backbone of His-352 and the adenine ring, and the C3"-H...C4 interaction.	Histidine	187-190	adenosylhomocysteinase	Homo sapiens	116-125
34734351-2	2021	Histidine decarboxylase (HDC), the unique enzyme that converts L-histidine to histamine, is highly expressed in CD11b+ immature myeloid cells.	Histidine	63-74	integrin subunit alpha M	Homo sapiens	112-117
29566507-2	2018	Recently, a potential treatment for CO poisoning was introduced, based on binding of CO by neuroglobin (Ngb) with a mutated distal histidine (H64Q).	Histidine	131-140	neuroglobin	Homo sapiens	91-102
29566507-2	2018	Recently, a potential treatment for CO poisoning was introduced, based on binding of CO by neuroglobin (Ngb) with a mutated distal histidine (H64Q).	Histidine	131-140	neuroglobin	Homo sapiens	104-107
29513344-0	2018	Antioxidant activity and inhibitory effects of 2-hydroxy-3-methylcyclopent-2-enone isolated from ribose-histidine Maillard reaction products on aldose reductase and tyrosinase.	Histidine	104-113	tyrosinase	Homo sapiens	165-175
11741986-7	2002	The sequence of the protease domain carried the essential triad His, Asp, and Ser and showed some similarity to that of TMPRSS2, hepsin, HAT, MT-SP1, TMPRSS3, and corin, sharing 45.5, 41.9, 41.3, 40.3, 39.1, and 38.5% identity, respectively.	Histidine	64-67	ST14 transmembrane serine protease matriptase	Homo sapiens	142-148
29513344-3	2018	Among the MRPs, ribose-histidine MRPs (RH-MRPs) showed the highest inhibitory activities on the ABTS+ radical scavenging ability, aldose reductase (AR), and tyrosinase compared to other MRPs.	Histidine	23-32	tyrosinase	Homo sapiens	157-167
34544605-5	2022	O2 enters mammalian Mb and the alpha and beta subunits of human HbA through a channel created by upward and outward rotation of the distal His at the E7 helical position, is non-covalently captured in the interior of the distal cavity, and then internally forms a bond with the heme Fe(II) atom.	Histidine	139-142	keratin 90, pseudogene	Homo sapiens	64-67
11741986-7	2002	The sequence of the protease domain carried the essential triad His, Asp, and Ser and showed some similarity to that of TMPRSS2, hepsin, HAT, MT-SP1, TMPRSS3, and corin, sharing 45.5, 41.9, 41.3, 40.3, 39.1, and 38.5% identity, respectively.	Histidine	64-67	transmembrane serine protease 3	Homo sapiens	150-157
11891044-4	2002	All these HELP domain-containing proteins, including mouse KE4, Drosophila Catsup, and Arabidopsis IAR1, possessed multipass transmembrane domains and histidine-rich sequences.	Histidine	151-160	solute carrier family 39 (zinc transporter), member 7	Mus musculus	59-62
34082042-7	2021	Western blot using anti-His tag antibody confirmed the presence of rHC-CS.	Histidine	24-27	holocytochrome c synthase	Rattus norvegicus	67-73
29300896-5	2018	The acceptor bead is modified with Ni(II), and is used to bind a specific recombinant HA-binding protein (such as HABP; aggrecan G1-IGD-G2) with a His-tag.	Histidine	147-150	hyaluronan binding protein 2	Homo sapiens	114-118
11812233-9	2002	A far UV circular dichroism spectrum revealed that His-tagged S. aureus Pth appears to have a structured core predominated by beta-sheet.	Histidine	51-54	AT695_RS00135	Staphylococcus aureus	72-75
29220567-7	2018	Although KDM6A and KDM6B differ in primary sequence, particularly in the H3L20 binding pocket of the zinc binding domains, where two histidines in KDM6A have been replaced by a glutamate and a tyrosine, they bind H3(17-23) in a very similar fashion.	Histidine	133-143	lysine demethylase 6B	Homo sapiens	19-24
29217657-0	2018	The unique histidine in OSCP subunit of F-ATP synthase mediates inhibition of the permeability transition pore by acidic pH.	Histidine	11-20	ATP synthase peripheral stalk subunit OSCP	Homo sapiens	24-28
28460164-5	2018	As expected, our hybrid molecule 10 [SNIPER(CH6)] efficiently degraded His-tagged CRABP-II and Smad2 in cells.	Histidine	71-74	cellular retinoic acid binding protein 2	Homo sapiens	82-90
34209660-2	2021	One of the strongest genetic risk factors for AMD is a complement factor H (CFH) gene polymorphism characterized by a tyrosine-histidine change at amino acid position 402 (Y402H).	Histidine	127-136	complement factor H	Homo sapiens	55-74
34209660-2	2021	One of the strongest genetic risk factors for AMD is a complement factor H (CFH) gene polymorphism characterized by a tyrosine-histidine change at amino acid position 402 (Y402H).	Histidine	127-136	complement factor H	Homo sapiens	76-79
35460908-4	2022	In brief, Met and glucose oxidase (GOx) was encapsulated into histidine/zeolitic imidazolate framework-8 (His/ZIF-8), which was followed by coating with Arg-Gly-Asp (RGD) peptides to obtain the desired nanomedicine (Met/GOx@His/ZIF-8~RGD).	Histidine	62-71	hydroxyacid oxidase 1	Homo sapiens	18-33
35460908-4	2022	In brief, Met and glucose oxidase (GOx) was encapsulated into histidine/zeolitic imidazolate framework-8 (His/ZIF-8), which was followed by coating with Arg-Gly-Asp (RGD) peptides to obtain the desired nanomedicine (Met/GOx@His/ZIF-8~RGD).	Histidine	62-71	hydroxyacid oxidase 1	Homo sapiens	35-38
35460908-4	2022	In brief, Met and glucose oxidase (GOx) was encapsulated into histidine/zeolitic imidazolate framework-8 (His/ZIF-8), which was followed by coating with Arg-Gly-Asp (RGD) peptides to obtain the desired nanomedicine (Met/GOx@His/ZIF-8~RGD).	Histidine	62-71	hydroxyacid oxidase 1	Homo sapiens	220-223
35529437-7	2022	In particular, l-histidine (fold change = 91.5, p = 0.01) showed significantly higher levels in the immediate HSR group, while myristicin (fold change = 0.218, p = 0.003), urocanic acid (fold change = 0.193, p = 0.007), and d-aldose (fold change = 0.343, p = 0.003) showed significantly lower levels in the same group.	Histidine	15-26	HSR	Homo sapiens	110-113
35529437-11	2022	These findings suggested that l-histidine can be a potential biomarker for PLD-induced HSR.	Histidine	30-41	HSR	Homo sapiens	87-90
11738613-1	2002	A compound named HPH-Pep, a peptide constructed from pyridine and histidine units, showed sensitizing effect on the hyperthermic treatment of L-1210, Molt-4, and HL60 cells.	Histidine	66-75	progestagen associated endometrial protein	Homo sapiens	21-24
35531278-0	2022	Deletion of Non-histidine Domains of Histidine Kinase CHK1 Diminishes the Infectivity of Candida albicans in an Oral Mucosal Model.	Histidine	16-25	checkpoint kinase 1	Mus musculus	54-58
11739744-5	2002	A histidine-rich stretch, which is conserved between CycT1 and CycT2 in this region, bound the C-terminal domain of RNAPII.	Histidine	2-11	cyclin T2	Homo sapiens	63-68
35427157-4	2022	Mutational analysis revealed that the predicted catalytic residues histidine-166 and cysteine-280 are critical for Cln5 thioesterase activity, uncovering a new cysteine-based catalytic mechanism for S-depalmitoylation enzymes.	Histidine	67-76	CLN5 intracellular trafficking protein	Homo sapiens	115-119
29278328-3	2018	Here we map the spin density distribution onto the cysteine ligands for the three major classes of the protein-bound, reduced [2Fe-2S](His)n(Cys)4-n (n = 0, 1, 2) cluster by selective cysteine-13Cbeta isotope labeling.	Histidine	135-138	spindlin 1	Homo sapiens	16-20
11750057-7	2001	In addition, mutational analysis of His(6)-p15 demonstrated that both intramolecular disulfide bonds are essential for its biological activity.	Histidine	36-39	cyclin-dependent kinase inhibitor 2B	Rattus norvegicus	43-46
29129814-1	2018	Cav3.2 T-type Ca2+ channel activity is suppressed by zinc that binds to the extracellular histidine-191 of Cav3.2, and enhanced by H2S that interacts with zinc.	Histidine	90-99	calcium channel, voltage-dependent, T type, alpha 1H subunit	Mus musculus	0-6
29129814-1	2018	Cav3.2 T-type Ca2+ channel activity is suppressed by zinc that binds to the extracellular histidine-191 of Cav3.2, and enhanced by H2S that interacts with zinc.	Histidine	90-99	calcium channel, voltage-dependent, T type, alpha 1H subunit	Mus musculus	107-113
35156774-6	2022	Docking study of this compound demonstrated that compound 7o interacted with critical histidine residues within tyrosinase active site.	Histidine	86-95	tyrosinase	Homo sapiens	112-122
35077997-1	2022	Protein disulfide isomerase (PDI), an oxidoreductase, possesses two vicinal cysteines in the -Cys-Gly-His-Cys-motif that either form a disulfide bridge (S-S) or exist in a sulfhydryl form (-SH), forming oxidized or reduced PDI, respectively.	Histidine	102-105	thioredoxin reductase 1	Homo sapiens	38-52
11717523-2	2001	In this study, the crystallization and preliminary crystallographic analysis of C-terminal His-tagged human AGT expressed in Escherichia coli is reported.	Histidine	91-94	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	108-111
35370775-2	2022	In addition, we found colocalization of NPGL, NPGM, and histidine decarboxylase (HDC; histamine-producing enzyme) in same neurons of the medial mammillary nucleus of the hypothalamus.	Histidine	56-65	histidine decarboxylase	Gallus gallus	81-84
35142326-0	2022	Importance of Ile71 in beta-actin on histidine methyltransferase SETD3 catalysis.	Histidine	37-46	POTE ankyrin domain family member F	Homo sapiens	23-33
29342843-6	2018	For the protonated noncovalent complexes of His enantiomers with tripeptides (AAA, SAA, ASA, and AAS), protonated His was observed in the spectra, except for those of heterochiral H+(d-His)SAA and H+(d-His)AAS, indicating that d-His did not accept protons from the SAA and AAS in the noncovalent complexes.	Histidine	44-47	serum amyloid A1 cluster	Homo sapiens	83-86
29342843-6	2018	For the protonated noncovalent complexes of His enantiomers with tripeptides (AAA, SAA, ASA, and AAS), protonated His was observed in the spectra, except for those of heterochiral H+(d-His)SAA and H+(d-His)AAS, indicating that d-His did not accept protons from the SAA and AAS in the noncovalent complexes.	Histidine	44-47	serum amyloid A1 cluster	Homo sapiens	189-192
29342843-6	2018	For the protonated noncovalent complexes of His enantiomers with tripeptides (AAA, SAA, ASA, and AAS), protonated His was observed in the spectra, except for those of heterochiral H+(d-His)SAA and H+(d-His)AAS, indicating that d-His did not accept protons from the SAA and AAS in the noncovalent complexes.	Histidine	44-47	serum amyloid A1 cluster	Homo sapiens	189-192
11698233-4	2001	When expressed in Xenopus laevis oocytes and in mammalian cells, rat SN2 mediates Na(+)-dependent transport of several neutral amino acids, including glycine, asparagine, alanine, serine, glutamine, and histidine.	Histidine	203-212	solute carrier family 38, member 5	Rattus norvegicus	69-72
29578158-3	2018	Materials and Methods: In this study, we constructed a eukaryotic expression vector pcDNA3.1D/V5-His-TOPO/Syk and transfected it into human nonsmall cell lung cancer cells A549.	Histidine	97-100	spleen associated tyrosine kinase	Homo sapiens	106-109
28923481-0	2017	ADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after Histidine 157.	Histidine	147-156	ADAM metallopeptidase domain 17	Homo sapiens	0-6
35174171-6	2021	Our docking results also revealed that ARG-120, TRP-126, and HIS-187 were critical sites responsible for interaction of SIRT7 with small molecules.	Histidine	61-64	sirtuin 7	Homo sapiens	120-125
35224154-3	2022	In many conditions, the histidine-rich region of HRGP strengthens ligand binding following interaction with Zn2+ or exposure to low pH, such as sites of tissue injury or tumor growth.	Histidine	24-33	histidine rich glycoprotein	Homo sapiens	49-53
28913669-10	2017	These studies identified a copper-binding site involving histidines at positions 2 and 3 that confers a remarkable stabilization of PAI-1 beyond what is observed with vitronectin alone.	Histidine	57-67	vitronectin	Homo sapiens	167-178
11724901-3	2001	We have developed a rabbit polyclonal antibody, SK601, that is highly specific for the PTTG1 gene product using recombinant PTTG1 protein (24 kD) containing an N-terminal His(6) tag as the immunogen.	Histidine	171-174	PTTG1 regulator of sister chromatid separation, securin	Homo sapiens	87-92
11738047-6	2001	The L19 peptide is in a centrally bulged conformation that is stabilized by intramolecular interactions from the invariant P7 histidine anchor residue and by a hydrophobic core of preferred secondary anchor residues that have minimal interaction with the MHC.	Histidine	126-135	skull development traits QTL 11	Mus musculus	4-7
11731082-8	2001	Subsequently, when the amino acid composition of CP reacted with AAPH was analyzed, cysteine, tryptophan, methionine, histidine, tyrosine, and lysine residues were particularly sensitive.	Histidine	118-127	ceruloplasmin	Homo sapiens	49-51
28455790-5	2017	The pull-down assay was performed using recombinant His-tagged TWEAK and AGEs.	Histidine	52-55	TNF superfamily member 12	Homo sapiens	63-68
11716696-7	2001	Upon postlabeling of [K4(PADA)]-NPY, 99mTc(CO)3 did not only bind to the desired PADA, but presumably as well to the His in position 26.	Histidine	117-120	neuropeptide Y	Homo sapiens	32-35
28807436-3	2017	The designed hybrid molecules, BS-Tat-Ni-NTA, MV1-Tat-Ni-NTA, BS-R9-Ni-NTA, and MV1-R9-Ni-NTA, efficiently degraded His-tagged cellular retinoic acid binding protein 2 via the ubiquitin-proteasome system (UPS).	Histidine	116-119	cellular retinoic acid binding protein 2	Homo sapiens	127-167
28625912-4	2017	The specific activity of the freshly purified hGAPDH constitutes 117 +- 5 mumol NADH/min per mg protein (pH 9.0, 22  C), which is close to the specific activity of rabbit muscle glyceraldehyde-3-phosphate dehydrogenase determined under the same conditions and several times exceeds the specific activity of his-tagged GAPDH preparations.	Histidine	307-310	glyceraldehyde-3-phosphate dehydrogenase	Oryctolagus cuniculus	47-52
11580291-6	2001	The functional epitope on human uPAR for this antagonist has been delineated by site-directed mutagenesis, and its assignment to loop 3 of uPAR domain III (Met(246), His(249), His(251), and Phe(256)) corroborates data previously obtained by photoaffinity labeling and provides a molecular explanation for the extreme selectivity observed for the antagonist toward human compared to mouse, monkey, and hamster uPAR.	Histidine	166-169	plasminogen activator, urokinase receptor	Homo sapiens	32-36
28774948-7	2017	We also found that DrHv1 is comparatively resistant to extracellular Zn2+, which is a potent inhibitor of mammalian Hv1, and this phenomenon appears to reflect variation in the Zn2+-coordinating residue (histidine) within the extracellular linker region in mammalian Hv1.	Histidine	204-213	hydrogen voltage-gated channel 1	Danio rerio	19-24
11580291-6	2001	The functional epitope on human uPAR for this antagonist has been delineated by site-directed mutagenesis, and its assignment to loop 3 of uPAR domain III (Met(246), His(249), His(251), and Phe(256)) corroborates data previously obtained by photoaffinity labeling and provides a molecular explanation for the extreme selectivity observed for the antagonist toward human compared to mouse, monkey, and hamster uPAR.	Histidine	176-179	plasminogen activator, urokinase receptor	Homo sapiens	32-36
11532454-3	2001	To obtain sufficient amounts of AQP2 for structural analyses, we have expressed recombinant his-tagged human AQP2 (HT-AQP2) in the baculovirus/insect cell system.	Histidine	92-95	aquaporin 2	Homo sapiens	32-36
11532454-3	2001	To obtain sufficient amounts of AQP2 for structural analyses, we have expressed recombinant his-tagged human AQP2 (HT-AQP2) in the baculovirus/insect cell system.	Histidine	92-95	aquaporin 2	Homo sapiens	109-113
27915022-0	2017	Concentration dependent survival and neural differentiation of murine embryonic stem cells cultured on polyethylene glycol dimethacrylate hydrogels possessing a continuous concentration gradient of n-cadherin derived peptide His-Ala-Val-Asp-Lle.	Histidine	225-228	cadherin 2	Mus musculus	198-208
11532454-3	2001	To obtain sufficient amounts of AQP2 for structural analyses, we have expressed recombinant his-tagged human AQP2 (HT-AQP2) in the baculovirus/insect cell system.	Histidine	92-95	aquaporin 2	Homo sapiens	115-122
11415439-3	2001	We demonstrate here that CaBP1, similar to PDI and CaBP2, can complement the lethal phenotype of the disrupted Saccharomyces cerevisiae PDI gene, provided that the natural C-terminal Lys-Asp-Glu-Leu sequence is replaced by His-Asp-Glu-Leu.	Histidine	223-226	calcium binding protein 1	Rattus norvegicus	25-30
28695845-3	2017	ACHT1 (atypical cysteine/histidine-rich Trx1) is a thylakoid-associated thioredoxin-type protein found in the Arabidopsis thaliana chloroplast.	Histidine	25-34	atypical CYS HIS rich thioredoxin 1	Arabidopsis thaliana	0-5
11396977-4	2001	Under native conditions, the soluble cytosolic His(6)-hAR was purified to apparent homogeneity in the presence of dihydrotestosterone, using metal ion affinity chromatography.	Histidine	47-50	lymphatic vessel endothelial hyaluronan receptor 1	Homo sapiens	54-57
28332148-3	2017	We previously demonstrated that regulation of HSPB5 is mediated by a single conserved histidine over a physiologically relevant pH range of 6.5-7.5.	Histidine	86-95	crystallin alpha B	Homo sapiens	46-51
11278664-7	2001	Mutant ST8Sia II and IV enzymes in which this His residue was changed to Lys showed no detectable enzyme activity, even though they were folded correctly and could bind to CDP-hexanolamine, suggesting the importance of the His residue for their catalytic activity.	Histidine	46-49	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	Homo sapiens	7-16
11278664-7	2001	Mutant ST8Sia II and IV enzymes in which this His residue was changed to Lys showed no detectable enzyme activity, even though they were folded correctly and could bind to CDP-hexanolamine, suggesting the importance of the His residue for their catalytic activity.	Histidine	223-226	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	Homo sapiens	7-16
28160314-8	2017	Unexpectedly, we also find that mutating the supposed catalytic histidine (H191) within the conserved HXXXDG active site motif only moderately reduces the thioesterase activity of Atf1p.	Histidine	64-73	alcohol O-acetyltransferase	Saccharomyces cerevisiae S288C	180-185
28566767-6	2017	The "His carrier" (His/His or His/Arg) of rs1229984 (His48Arg) of ADH1B significantly increased gout risk (P = 4.3 x 10-4, odds ratio = 1.76), as did the "non-Lys carrier (Glu/Glu)" of rs671 (Glu504Lys) of ALDH2.	Histidine	5-8	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	66-71
28566767-6	2017	The "His carrier" (His/His or His/Arg) of rs1229984 (His48Arg) of ADH1B significantly increased gout risk (P = 4.3 x 10-4, odds ratio = 1.76), as did the "non-Lys carrier (Glu/Glu)" of rs671 (Glu504Lys) of ALDH2.	Histidine	19-22	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	66-71
28566767-6	2017	The "His carrier" (His/His or His/Arg) of rs1229984 (His48Arg) of ADH1B significantly increased gout risk (P = 4.3 x 10-4, odds ratio = 1.76), as did the "non-Lys carrier (Glu/Glu)" of rs671 (Glu504Lys) of ALDH2.	Histidine	19-22	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	66-71
11300772-0	2001	Evidence for an essential histidine residue in the ascorbate-binding site of cytochrome b561.	Histidine	26-35	cytochrome b561	Homo sapiens	77-92
28380621-13	2017	1 indicated that the SID of His, Lys, and Thr tended ( &lt; 0.10) to be greater in SPC ground to 180 mum than in soybean meal, and the SID of Arg, Ile, Phe, and Trp was greater ( &lt; 0.05) in SPC ground to 70 or 180 mum than in soybean meal.	Histidine	28-31	surfactant protein C	Sus scrofa	83-86
11264017-2	2001	The Cys(2)/His(2) zinc finger is a structural motif required for sequence-specific DNA binding and is present in zinc finger transcription factors (ZFP): Sp1, Egr-1, and TFIIIA.	Histidine	11-14	early growth response 1	Homo sapiens	159-164
11238646-7	2001	Mutational analysis of residues participating in the formation of this pocket demonstrates that Asp(112) and Tyr(175) are important contact residues for C1q binding, that Glu(88) influences the conformational change in C1q necessary for complement activation, and that Asn(158) and His(38) probably contribute to the correct geometry of the binding site.	Histidine	282-285	complement C1q A chain	Homo sapiens	153-156
27966610-0	2016	Molecular mechanism: the human dopamine transporter histidine 547 regulates basal and HIV-1 Tat protein-inhibited dopamine transport.	Histidine	52-61	solute carrier family 6 member 3	Homo sapiens	31-51
27966610-0	2016	Molecular mechanism: the human dopamine transporter histidine 547 regulates basal and HIV-1 Tat protein-inhibited dopamine transport.	Histidine	52-61	Tat	Human immunodeficiency virus 1	92-95
11238646-7	2001	Mutational analysis of residues participating in the formation of this pocket demonstrates that Asp(112) and Tyr(175) are important contact residues for C1q binding, that Glu(88) influences the conformational change in C1q necessary for complement activation, and that Asn(158) and His(38) probably contribute to the correct geometry of the binding site.	Histidine	282-285	complement C1q A chain	Homo sapiens	219-222
11300822-5	2001	Electron paramagnetic resonance at 15 K further indicated that the iron-histidine bond is cleaved to form a five-coordinate derivative in some fraction of the myoglobin.	Histidine	72-81	myoglobin	Homo sapiens	159-168
27928027-3	2016	Ngb is a six-coordinate hemoprotein, with the heme iron coordinated by two histidine residues.	Histidine	75-84	neuroglobin	Homo sapiens	0-3
11263872-1	2001	Early reports of a severely bent CO adduct in myoglobin inspired the idea that heme proteins discriminate against CO, relative to O(2), via steric hindrance imposed by a distal histidine residue.	Histidine	177-186	myoglobin	Homo sapiens	46-55
27766492-4	2016	Fe(II) DGCR8 RNA-binding heme domain (Rhed) undergoes a pH-dependent transition from 6-coordinate to 5-coordinate, due to protonation and loss of a lysine ligand; the ligand bound throughout the pH change is a histidine.	Histidine	210-219	DGCR8 microprocessor complex subunit	Homo sapiens	7-12
11160624-0	2001	Differential sensitivity of Kv1.4, Kv1.2, and their tandem channel to acidic pH: involvement of a histidine residue in high sensitivity to acidic pH.	Histidine	98-107	potassium voltage-gated channel subfamily A member 4	Homo sapiens	28-33
27822212-5	2016	A separate cohort of animals was used to detect His-tagged HMGB1 in the brain.	Histidine	48-51	high mobility group box 1	Rattus norvegicus	59-64
11160624-4	2001	Mutagenesis analysis identified the histidine residue at 508 (H508) in the S5-H5 linker as a molecular determinant of pH sensitivity of Kv1.4.	Histidine	36-45	potassium voltage-gated channel subfamily A member 4	Homo sapiens	136-141
11604705-0	2001	"THE PILOT": a tool for connecting existing HIS to an extranet quickly, easily and smoothly.	Histidine	44-47	early growth response 3	Homo sapiens	5-11
27493214-14	2016	Intriguingly, structural analysis showed that a potential His-binding domain was present in the general amino acid sensors GENERAL CONTROL NON-DEREPRESSIBLE2 and PII, suggesting that His may serve as a signal molecule.	Histidine	58-61	nitrogen regulatory P-II-like protein	Arabidopsis thaliana	131-165
27493214-14	2016	Intriguingly, structural analysis showed that a potential His-binding domain was present in the general amino acid sensors GENERAL CONTROL NON-DEREPRESSIBLE2 and PII, suggesting that His may serve as a signal molecule.	Histidine	183-186	nitrogen regulatory P-II-like protein	Arabidopsis thaliana	131-165
11093950-8	2000	Diethylpyrocarbonate inhibition of iron uptake in DMT1-transfected cells suggests a functional role for histidine residues.	Histidine	104-113	doublesex and mab-3 related transcription factor 1	Homo sapiens	50-54
27546061-9	2016	Electron-nuclear double resonance spectroscopy data exclude histidine or water as axial ligands for ferric DGCR8 and favor bis-thiolate coordination in this form.	Histidine	60-69	DGCR8 microprocessor complex subunit	Homo sapiens	107-112
11095676-3	2000	Bas1p is a Myb-related transcription factor that acts together with the homeodomain-related Bas2p (Pho2p) to regulate purine and histidine biosynthesis genes in response to extracellular purine limitation.	Histidine	129-138	Pho2p	Saccharomyces cerevisiae S288C	92-97
27346274-11	2016	Additional mutants in EC1/TM3 explored the molecular basis for these changes demonstrated in EC1, particularly important is the presence of aromatic-interactions by His(107), rather than hydrogen-bonding or charge-charge interactions, for determining Bantag-1 high affinity/selectivity.	Histidine	165-168	tropomyosin 3	Homo sapiens	26-29
11095676-3	2000	Bas1p is a Myb-related transcription factor that acts together with the homeodomain-related Bas2p (Pho2p) to regulate purine and histidine biosynthesis genes in response to extracellular purine limitation.	Histidine	129-138	Pho2p	Saccharomyces cerevisiae S288C	99-104
11191882-3	2000	We have found the following frequencies of mutated alleles: CYP1A1-m2, 0.097; CYP2E1-C, 0.077; CYP2E1-c2, 0.023; EPHX(exon 3)-His, 0.381; EPHX(exon 4)-Arg, 0.198; GSTM1-null, 0.51; GSTP1-Val, 0.3; GSTT1-null, 0.164.	Histidine	126-129	epoxide hydrolase 1	Homo sapiens	113-117
27387499-4	2016	We have focused our attention on active-site residues of PRMT7 from the protozoan Trypanosoma brucei We have designed 26 single and double mutations in the active site, including residues in the Glu-Xaa8-Glu (double E) loop and the Met-Gln-Trp sequence of the canonical Thr-His-Trp (THW) loop known to interact with the methyl-accepting substrate arginine.	Histidine	274-277	protein arginine methyltransferase 7	Homo sapiens	57-62
11029294-12	2000	Combined mutations of the lysine and histidine residues in Kir4.1 (K53V/S328H/G340H) gave rise to a channel that had CO(2)/pH sensitivities almost identical to those of the wild-type Kir1.1.	Histidine	37-46	potassium inwardly rectifying channel subfamily J member 10	Homo sapiens	59-65
11155228-4	2000	The zinc ion forms a stable complex with His 119(GH1) on the Mb surface at the equimolar Zn2+ concentration.	Histidine	41-44	somatotropin	Physeter catodon	49-52
27431616-4	2016	The order of reactivity of nucleophiles was: Tu &gt; l-Met &gt; l-Cys &gt; l-His &gt; 5"-GMP.	Histidine	75-80	5'-nucleotidase, cytosolic II	Homo sapiens	89-92
11054275-4	2000	Bacterially expressed ChIL-18 in which the N-terminal 29 amino acids of the putative precursor molecule were replaced by a histidine tag induced the synthesis of interferon-gamma (IFN-gamma) in cultured primary chicken spleen cells, indicating that the recombinant protein is biologically active.	Histidine	123-132	interleukin 18	Gallus gallus	22-29
27284165-12	2016	A corresponding histidine insertion into the Gld2 active site alters substrate specificity from ATP to UTP.	Histidine	16-25	terminal nucleotidyltransferase 2	Homo sapiens	45-49
11018678-3	2000	The complex formation of Zn(2+) with the central histidine-rich motif of B18 appears to shift the secondary structure away from a beta-sheet towards an alpha-helical conformation.	Histidine	49-58	NADH:ubiquinone oxidoreductase subunit B7	Homo sapiens	73-76
26756542-0	2016	Identification of putative unfolding intermediates of the mutant His-107-tyr of human carbonic anhydrase II in a multidimensional property space.	Histidine	65-68	carbonic anhydrase 2	Homo sapiens	86-107
26756542-9	2016	We have focused on the application of this method to partition a wide array of conformations of wild type human carbonic anhydrase II (HCA II) and its unstable mutant His-107-Tyr along dmean by sampling a 35-dimensional property space.	Histidine	167-170	carbonic anhydrase 2	Homo sapiens	112-133
26476866-7	2016	In case of Fc region of IgG, l-histidine and histidyl moieties closely resemble the binding modes of Protein A, biomimetic ligand 22/8 and B domain of SpA to IgG.	Histidine	29-40	surfactant protein A2	Homo sapiens	151-154
10985787-2	2000	The binding of E12 was localized to the N-terminal, regulatory domain of VanR which contains Asp-55, the residue which accepts the phosphoryl group from His-164 in the activated VanS sensor kinase.	Histidine	153-156	VanS protein	Enterococcus faecium	178-182
10999600-4	2000	Comparison of the yeast and human UPF1 proteins demonstrated that the amino terminal cysteine/histidine-rich region and the region comprising the domains that define this protein as a superfamily group I helicase have been conserved.	Histidine	94-103	UPF1 RNA helicase and ATPase	Homo sapiens	34-38
27018871-1	2016	Human FAM76B (hFAM76B) is a 39 kDa protein that contains homopolymeric histidine tracts, a targeting signal for nuclear speckles.	Histidine	71-80	family with sequence similarity 76 member B	Homo sapiens	6-12
10964668-2	2000	In Western blot analysis, hg303 recognizes both wild type and C-terminal Myc-His-tagged human DNase gamma, but does not cross-react with human DNase I family members, DNase I, DNase X, or DNAS1L2.	Histidine	77-80	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	73-76
27018871-1	2016	Human FAM76B (hFAM76B) is a 39 kDa protein that contains homopolymeric histidine tracts, a targeting signal for nuclear speckles.	Histidine	71-80	family with sequence similarity 76 member B	Homo sapiens	14-21
10964668-2	2000	In Western blot analysis, hg303 recognizes both wild type and C-terminal Myc-His-tagged human DNase gamma, but does not cross-react with human DNase I family members, DNase I, DNase X, or DNAS1L2.	Histidine	77-80	deoxyribonuclease 1 like 3	Homo sapiens	94-105
10823841-5	2000	Interestingly the mutation in STAT5A-N642H resulted in restoration of the conserved critical histidine which is involved in the binding of phosphotyrosine in the majority of SH2-containing proteins.	Histidine	93-102	signal transducer and activator of transcription 5A	Mus musculus	30-36
26621552-6	2016	Taking advantage of its N-terminal His-tag, rLF was then purified with Ni-affinity chromatography.	Histidine	35-38	RLF zinc finger	Rattus norvegicus	44-47
10889031-9	2000	Further, it appears that a concerted cleavage of both His ligands takes place, suggesting indeed that the different axial ligands present in horse heart cytochrome c (Met/His) and in cytochrome c" from M. methylotrophus (His/His) affect the heme conformational changes.	Histidine	54-57	cytochrome c, somatic	Equus caballus	153-165
26694607-4	2016	TgLCAT contains a motif characteristic of serine lipases "AHSLG" and the catalytic triad consisting of serine, aspartate, and histidine (SDH) from LCAT enzymes.	Histidine	126-135	lecithin-cholesterol acyltransferase	Homo sapiens	2-6
10889031-9	2000	Further, it appears that a concerted cleavage of both His ligands takes place, suggesting indeed that the different axial ligands present in horse heart cytochrome c (Met/His) and in cytochrome c" from M. methylotrophus (His/His) affect the heme conformational changes.	Histidine	54-57	cytochrome c, somatic	Equus caballus	183-195
10899637-4	2000	The inactivated dimer was hybridized with native dimeric muscle enzyme (MM-CK) to produce a partially inactivated MB*-CK heterodimeric hybrid and also to a his-tagged BB-CK (hBhB-CK) resulting in a partially inactive hBB*-CK homodimer.	Histidine	156-159	hemoglobin subunit beta	Homo sapiens	167-169
26472619-3	2016	Ferret recombinant IL-2 incorporating a C-terminal histidine tag was expressed and purified and the three-dimensional structure solved and refined at 1.89 A by X-ray crystallography, which represents the highest resolution and first non-human IL-2 structure.	Histidine	51-60	interleukin 2	Mustela putorius furo	19-23
10860823-0	2000	Functional roles of histidine and tyrosine residues in the H(+)-peptide transporter PepT1.	Histidine	20-29	solute carrier family 15 member 1	Oryctolagus cuniculus	84-89
26657319-1	2016	Transition metal-nitrogen/carbon (M-N/C, M = Fe, Co) catalysts are synthesized using environmentally friendly histidine-tag-rich elastin protein beads, metal sulfate and water soluble carbon nanotubes followed by post-annealing and acid leaching processes.	Histidine	110-119	elastin	Homo sapiens	129-136
10841784-5	2000	Zn(II) binds to the N(tau) atom of the histidine imidazole ring and the peptide aggregates through intermolecular His(N(tau))-Zn(II)-His(N(tau)) bridges.	Histidine	114-117	microtubule associated protein tau	Homo sapiens	22-25
26812651-2	2016	Symmetric heteroduplex arises from Holliday junction migration, and we suggest this mechanism explains the high frequency of His+ spores in heteroallelic crosses in which recombination is initiated cis to the his-3 allele further from the initiator, cog+.	Histidine	125-128	imidazoleglycerol-phosphate dehydratase HIS3	Saccharomyces cerevisiae S288C	209-214
26812651-3	2016	In contrast, when recombination is initiated cis to the his-3 allele closer to cog+, His+ spores are mainly a result of synthesis-dependent strand annealing, yielding asymmetric heteroduplex.	Histidine	85-88	imidazoleglycerol-phosphate dehydratase HIS3	Saccharomyces cerevisiae S288C	56-61
10841784-5	2000	Zn(II) binds to the N(tau) atom of the histidine imidazole ring and the peptide aggregates through intermolecular His(N(tau))-Zn(II)-His(N(tau)) bridges.	Histidine	114-117	microtubule associated protein tau	Homo sapiens	120-123
26657863-6	2016	Progesterone receptor membrane component-1 (PGRMC1) was required for HIS-dependent increases in hepcidin biosynthesis, as PGRMC1 depletion in cultured hepatoma cells and zebrafish blocked the ability of HISs to increase hepcidin mRNA levels.	Histidine	69-72	hepcidin antimicrobial peptide	Mus musculus	96-104
10841784-5	2000	Zn(II) binds to the N(tau) atom of the histidine imidazole ring and the peptide aggregates through intermolecular His(N(tau))-Zn(II)-His(N(tau)) bridges.	Histidine	114-117	microtubule associated protein tau	Homo sapiens	120-123
10841784-5	2000	Zn(II) binds to the N(tau) atom of the histidine imidazole ring and the peptide aggregates through intermolecular His(N(tau))-Zn(II)-His(N(tau)) bridges.	Histidine	133-136	microtubule associated protein tau	Homo sapiens	22-25
10841784-5	2000	Zn(II) binds to the N(tau) atom of the histidine imidazole ring and the peptide aggregates through intermolecular His(N(tau))-Zn(II)-His(N(tau)) bridges.	Histidine	133-136	microtubule associated protein tau	Homo sapiens	120-123
10841784-5	2000	Zn(II) binds to the N(tau) atom of the histidine imidazole ring and the peptide aggregates through intermolecular His(N(tau))-Zn(II)-His(N(tau)) bridges.	Histidine	133-136	microtubule associated protein tau	Homo sapiens	120-123
26585511-5	2015	With molecular dynamics simulations, this effect was traced to a histidine residue (H95) located in the cytoplasmic lumen of AQP4.	Histidine	65-74	aquaporin 4	Homo sapiens	125-129
10764730-2	2000	An important component of this system is the histidine-containing phosphocarrier protein, HPr, which accepts a phosphoryl group from enzyme I, transfers a phosphoryl group to IIA proteins, and is an allosteric regulator of glycogen phosphorylase.	Histidine	45-54	colicin Ia immunity protein	Escherichia coli	175-178
10825448-0	2000	Diethyl pyrocarbonate inactivates CD39/ecto-ATPDase by modifying His-59.	Histidine	65-68	ectonucleoside triphosphate diphosphohydrolase 1	Homo sapiens	34-38
26481857-7	2015	Moreover, histamine upregulated the GTP-bound small GTPase Rac1, while a Rac1 inhibitor, NSC23766, abrogated the neuroprotection of histidine and its promotion of astrocyte migration.	Histidine	132-141	Rac family small GTPase 1	Homo sapiens	59-63
26481857-7	2015	Moreover, histamine upregulated the GTP-bound small GTPase Rac1, while a Rac1 inhibitor, NSC23766, abrogated the neuroprotection of histidine and its promotion of astrocyte migration.	Histidine	132-141	Rac family small GTPase 1	Homo sapiens	73-77
26195630-6	2015	In contrast, mutations in the C-terminal hinge-cysteine-histidine-rich domain segment primarily affected the PCSK9-induced CD81 degradation.	Histidine	56-65	CD81 molecule	Homo sapiens	123-127
10825448-0	2000	Diethyl pyrocarbonate inactivates CD39/ecto-ATPDase by modifying His-59.	Histidine	65-68	ectonucleoside triphosphate diphosphohydrolase 1	Homo sapiens	44-51
10825448-6	2000	Comparison of known sequences of CD39-like ecto-ATP(D)ases with the results on inactivation by DEPC revealed His-59 and His-251 (according to the human CD39 sequence) as equally possible targets of the inactivating DEPC modification.	Histidine	109-112	ectonucleoside triphosphate diphosphohydrolase 1	Homo sapiens	33-37
10825448-6	2000	Comparison of known sequences of CD39-like ecto-ATP(D)ases with the results on inactivation by DEPC revealed His-59 and His-251 (according to the human CD39 sequence) as equally possible targets of the inactivating DEPC modification.	Histidine	120-123	ectonucleoside triphosphate diphosphohydrolase 1	Homo sapiens	33-37
10825448-8	2000	Therefore, this enzyme was exposed to DEPC, and since hydrolysis of ATP and ADP by potato apyrase was insensitive to modification with DEPC, it was concluded that His-59 is the essential residue in CD39 that is affected by DEPC modification in a way that causes inactivation of the enzyme.	Histidine	163-166	ectonucleoside triphosphate diphosphohydrolase 1	Homo sapiens	198-202
10769175-5	2000	The human Delta(5)-desaturase contained a predicted N-terminal cytochrome b(5)-like domain, as well as three histidine-rich domains.	Histidine	109-118	fatty acid desaturase 1	Homo sapiens	10-29
26195630-7	2015	Furthermore, when C-terminally fused to an ACE2 transmembrane anchor, the secretory N-terminal catalytic or hinge-cysteine-histidine-rich domain domains of PCSK9 were able to reduce CD81 and LDLR levels.	Histidine	123-132	CD81 molecule	Homo sapiens	182-186
26216015-1	2015	Thyrotropin-releasing hormone (TRH)-like peptides were synthesized by replacing critical histidine and pGlu residues in the native peptide.	Histidine	89-98	thyrotropin releasing hormone	Mus musculus	31-34
10766788-7	2000	Based on sequence identity with the mammalian enzymes the proximal ligand in HO-1 (His-25) and HO-2 (His-45) is conserved (His-20) in the bacterial enzyme.	Histidine	83-86	heme oxygenase 1	Homo sapiens	77-81
26175473-6	2015	Our data raise major concerns about the usage of recombinant His-tagged GM2AP compared with untagged protein.	Histidine	61-64	ganglioside GM2 activator	Homo sapiens	72-77
10766788-7	2000	Based on sequence identity with the mammalian enzymes the proximal ligand in HO-1 (His-25) and HO-2 (His-45) is conserved (His-20) in the bacterial enzyme.	Histidine	101-104	heme oxygenase 1	Homo sapiens	77-81
10766788-7	2000	Based on sequence identity with the mammalian enzymes the proximal ligand in HO-1 (His-25) and HO-2 (His-45) is conserved (His-20) in the bacterial enzyme.	Histidine	101-104	heme oxygenase 1	Homo sapiens	77-81
10760284-1	2000	To understand the relevance of p53 missense mutations in vivo, we generated a mouse containing an arg-to-his substitution at p53 amino acid 172, which corresponds to the R175H hot-spot mutation in human tumors by homologous recombination.	Histidine	105-108	transformation related protein 53, pseudogene	Mus musculus	125-128
26263392-3	2015	We previously demonstrated that NCL changes its action on the human sweet receptor hT1R2-hT1R3 from antagonism to agonism as the pH changes from neutral to acidic values, and that the histidine residues of NCL molecule play critical roles in this pH-dependent functional change.	Histidine	184-193	taste 1 receptor member 2	Homo sapiens	83-88
10734219-2	2000	The sixA gene was originally identified as the one that interferes with, at its multi-copy state, the cross-phosphorelay between the histidine-containing phosphotransmitter (HPt) domain of the ArcB anaerobic sensor and its non-cognate OmpR response regulator.	Histidine	133-142	hypothetical protein	Escherichia coli	193-197
25900360-2	2015	The three CcP variants have Arg-48, Trp-51, and His-52 mutated to either all alanine, CcP(triAla), all valine, CcP(triVal), or all leucine residues, CcP(triLeu).	Histidine	48-51	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	10-13
10700443-3	2000	We prospectively studied the association of the histidine (H)(72)--&gt;tyrosine (Y) mutation in p22(phox) with the severity and progression/regression of coronary artery disease (CAD), plasma lipid levels, clinical events, and response to treatment with fluvastatin in a well-characterized population.	Histidine	48-57	calcineurin like EF-hand protein 1	Homo sapiens	96-99
26041283-8	2015	The covalent linking between nsP1 and m(7)GMP involves a phosphamide bond between the nucleotide and a histidine residue.	Histidine	103-112	SH2 domain containing 3A	Homo sapiens	29-33
26041283-8	2015	The covalent linking between nsP1 and m(7)GMP involves a phosphamide bond between the nucleotide and a histidine residue.	Histidine	103-112	5'-nucleotidase, cytosolic II	Homo sapiens	42-45
10803111-4	2000	A widespread histidine/tyrosine polymorphism was detected in codon 17 of S100A4.	Histidine	13-22	S100 calcium binding protein A4	Canis lupus familiaris	73-79
26200004-3	2015	(2015) show that a histidine residue in the RNA binding pocket of RIG-I sterically excludes the cap1 structure of self RNA, thereby preventing downstream activation.	Histidine	19-28	DExD/H-box helicase 58	Homo sapiens	66-71
10703921-6	2000	Treatment with a synthetic peptide containing the His-Ala-Val (HAV) adhesion motif of N-cadherin significantly decreased bone nodule formation in primary cultures of fetal rat calvaria and inhibited cell-to-cell contact in rat osteoblastic TRAB-11 cells.	Histidine	50-53	cadherin 2	Rattus norvegicus	86-96
25805806-1	2015	Among more than 30 members of the phospholipase A2 (PLA2) superfamily, secreted PLA2 (sPLA2) enzymes represent the largest family, being Ca(2+)-dependent low-molecular-weight enzymes with a His-Asp catalytic dyad.	Histidine	190-193	phospholipase A2, group IB, pancreas	Mus musculus	34-50
25805806-1	2015	Among more than 30 members of the phospholipase A2 (PLA2) superfamily, secreted PLA2 (sPLA2) enzymes represent the largest family, being Ca(2+)-dependent low-molecular-weight enzymes with a His-Asp catalytic dyad.	Histidine	190-193	phospholipase A2, group IB, pancreas	Mus musculus	52-56
25805806-1	2015	Among more than 30 members of the phospholipase A2 (PLA2) superfamily, secreted PLA2 (sPLA2) enzymes represent the largest family, being Ca(2+)-dependent low-molecular-weight enzymes with a His-Asp catalytic dyad.	Histidine	190-193	phospholipase A2, group IB, pancreas	Mus musculus	80-84
25805806-1	2015	Among more than 30 members of the phospholipase A2 (PLA2) superfamily, secreted PLA2 (sPLA2) enzymes represent the largest family, being Ca(2+)-dependent low-molecular-weight enzymes with a His-Asp catalytic dyad.	Histidine	190-193	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	86-91
10627551-9	2000	In addition, PrP(Sc) with the codon 171 (Gln-to-His) polymorphism is the first variant reported to induce higher conversion efficiencies with heterologous rather than homologous PrP variants.	Histidine	48-51	major prion protein	Ovis aries	13-16
25573590-9	2015	Compared with subjects having ALDH-2 Lys+ with ADH-1B His/His, ORs and 95%CIs for those with ALDH-2 Glu/Glu and ADH-1B His/His was 3.42(0.57-20.38).	Histidine	54-57	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	47-53
25573590-9	2015	Compared with subjects having ALDH-2 Lys+ with ADH-1B His/His, ORs and 95%CIs for those with ALDH-2 Glu/Glu and ADH-1B His/His was 3.42(0.57-20.38).	Histidine	54-57	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	112-118
25573590-9	2015	Compared with subjects having ALDH-2 Lys+ with ADH-1B His/His, ORs and 95%CIs for those with ALDH-2 Glu/Glu and ADH-1B His/His was 3.42(0.57-20.38).	Histidine	58-61	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	47-53
25573590-9	2015	Compared with subjects having ALDH-2 Lys+ with ADH-1B His/His, ORs and 95%CIs for those with ALDH-2 Glu/Glu and ADH-1B His/His was 3.42(0.57-20.38).	Histidine	58-61	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	112-118
25573590-9	2015	Compared with subjects having ALDH-2 Lys+ with ADH-1B His/His, ORs and 95%CIs for those with ALDH-2 Glu/Glu and ADH-1B His/His was 3.42(0.57-20.38).	Histidine	58-61	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	47-53
25573590-9	2015	Compared with subjects having ALDH-2 Lys+ with ADH-1B His/His, ORs and 95%CIs for those with ALDH-2 Glu/Glu and ADH-1B His/His was 3.42(0.57-20.38).	Histidine	58-61	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	112-118
25573590-9	2015	Compared with subjects having ALDH-2 Lys+ with ADH-1B His/His, ORs and 95%CIs for those with ALDH-2 Glu/Glu and ADH-1B His/His was 3.42(0.57-20.38).	Histidine	58-61	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	47-53
10627551-9	2000	In addition, PrP(Sc) with the codon 171 (Gln-to-His) polymorphism is the first variant reported to induce higher conversion efficiencies with heterologous rather than homologous PrP variants.	Histidine	48-51	major prion protein	Ovis aries	178-181
10617633-7	2000	Point mutations of conserved cysteine residues or a histidine in the RING finger domain, which are required for zinc binding, abrogated the ability of Cbl to negatively regulate Syk in COS-7 cells and Ramos B lymphocytic cells.	Histidine	52-61	Cbl proto-oncogene	Homo sapiens	151-154
25573590-9	2015	Compared with subjects having ALDH-2 Lys+ with ADH-1B His/His, ORs and 95%CIs for those with ALDH-2 Glu/Glu and ADH-1B His/His was 3.42(0.57-20.38).	Histidine	58-61	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	112-118
10649380-0	2000	How Strong Is the Coordination Bond between a Histidine Tag and Ni - Nitrilotriacetate?	Histidine	46-55	long intergenic non-protein coding RNA 1194	Homo sapiens	56-59
25962097-4	2015	Destabilization by pH or His-104 mutation shifts the ACD from dimer to monomer but also results in a large expansion of HSPB5 oligomer states.	Histidine	25-28	crystallin alpha B	Homo sapiens	120-125
10585483-4	1999	ArcB is a tripartite kinase, possessing a primary transmitter, a receiver, and a secondary transmitter domain that catalyzes the phosphorylation of ArcA via a His --&gt; Asp --&gt; His --&gt; Asp phosphorelay, as well as the dephosphorylation of ArcA-P by a reverse phosphorelay.	Histidine	159-162	hypothetical protein	Escherichia coli	0-4
10648963-8	1999	The cloned Ra-eRF1 gene complemented a temperature-sensitive allele in the eRF1 gene, sup45 (ts), of S. cerevisiae, though the complementation activity was significantly impaired by the histidine tag, whereas Tt-eRF1 failed to complement the sup45 (ts) allele.	Histidine	186-195	translation termination factor eRF1	Saccharomyces cerevisiae S288C	86-91
25344885-2	2015	In order to determine the host membrane proteins that interact with MSG1, recombinant His-tagged MSG1 (rMSG1) was used to screen for interacting proteins in the protein extracts of porcine erythrocyte membrane.	Histidine	86-89	Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1	Rattus norvegicus	68-72
25344885-2	2015	In order to determine the host membrane proteins that interact with MSG1, recombinant His-tagged MSG1 (rMSG1) was used to screen for interacting proteins in the protein extracts of porcine erythrocyte membrane.	Histidine	86-89	Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1	Rattus norvegicus	97-101
25344885-2	2015	In order to determine the host membrane proteins that interact with MSG1, recombinant His-tagged MSG1 (rMSG1) was used to screen for interacting proteins in the protein extracts of porcine erythrocyte membrane.	Histidine	86-89	Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1	Rattus norvegicus	103-108
10531481-0	1999	Refined structure of the histidine-containing phosphotransfer (HPt) domain of the anaerobic sensor kinase ArcB from Escherichia coli at 1.57 A resolution.	Histidine	25-34	hypothetical protein	Escherichia coli	106-110
25604895-2	2015	Kti11 was additionally shown to be implicated in the biosynthesis of diphthamide, a post-translationally modified histidine of translation elongation factor 2.	Histidine	114-123	diphthamide biosynthesis 3	Homo sapiens	0-5
10531481-1	1999	The crystal structure of the histidine-containing phosphotransfer (HPt) domain of the anaerobic sensor kinase ArcB from Escherichia coli has been refined to 1.57 A resolution, using the coordinates of the earlier 2.06 A structure as a starting model.	Histidine	29-38	hypothetical protein	Escherichia coli	110-114
10510301-12	1999	The pH-dependence of the midpoint transition temperature of endotherms indicated that the high difference in stabilization energy between aged and native BuChE (DeltaDeltaG=23.7 kJ/mol at pH 8.0) is mainly due to the salt bridge between protonated His-438 and PO(-), with pK(His-438)=8.3.	Histidine	248-251	butyrylcholinesterase	Homo sapiens	154-159
25267303-6	2015	In examples of the SUOX-fold and DMSOR-fold enzymes, we observe three types of histidine-containing charge-transfer relays that can: (1) connect the piperazine ring of the pyranopterin to the substrate-binding site (SUOX-fold enzymes); (2) provide inter-pyranopterin communication (DMSOR-fold enzymes); and (3) connect a pyran ring oxygen to deeply buried water molecules (the DMSOR-fold NarGHI-type nitrate reductases).	Histidine	79-88	sulfite oxidase	Homo sapiens	19-23
25267303-6	2015	In examples of the SUOX-fold and DMSOR-fold enzymes, we observe three types of histidine-containing charge-transfer relays that can: (1) connect the piperazine ring of the pyranopterin to the substrate-binding site (SUOX-fold enzymes); (2) provide inter-pyranopterin communication (DMSOR-fold enzymes); and (3) connect a pyran ring oxygen to deeply buried water molecules (the DMSOR-fold NarGHI-type nitrate reductases).	Histidine	79-88	sulfite oxidase	Homo sapiens	216-220
25742191-15	2015	In the example presented, the His3 enzyme, which is required for histidine biosynthesis, was fused to Deg1-Sec62.	Histidine	65-74	imidazoleglycerol-phosphate dehydratase HIS3	Saccharomyces cerevisiae S288C	30-34
25561737-8	2015	In CAII, binding to MCT1 and MCT4 is mediated by a histidine residue at position 64.	Histidine	51-60	carbonic anhydrase 2 S homeolog	Xenopus laevis	3-7
10510301-12	1999	The pH-dependence of the midpoint transition temperature of endotherms indicated that the high difference in stabilization energy between aged and native BuChE (DeltaDeltaG=23.7 kJ/mol at pH 8.0) is mainly due to the salt bridge between protonated His-438 and PO(-), with pK(His-438)=8.3.	Histidine	275-278	butyrylcholinesterase	Homo sapiens	154-159
25561737-9	2015	Taken together, our results suggest that facilitation of MCT transport activity by CAII requires direct binding between histidine 64 in CAII and a cluster of glutamic acid residues in the C terminus of the transporter that has to be positioned in surroundings that allow access to CAII.	Histidine	120-129	carbonic anhydrase 2 S homeolog	Xenopus laevis	83-87
25561737-9	2015	Taken together, our results suggest that facilitation of MCT transport activity by CAII requires direct binding between histidine 64 in CAII and a cluster of glutamic acid residues in the C terminus of the transporter that has to be positioned in surroundings that allow access to CAII.	Histidine	120-129	carbonic anhydrase 2 S homeolog	Xenopus laevis	136-140
25561737-9	2015	Taken together, our results suggest that facilitation of MCT transport activity by CAII requires direct binding between histidine 64 in CAII and a cluster of glutamic acid residues in the C terminus of the transporter that has to be positioned in surroundings that allow access to CAII.	Histidine	120-129	carbonic anhydrase 2 S homeolog	Xenopus laevis	136-140
10504448-7	1999	In addition two novel mutations within the helix initiation motif of hHb6 were found in Scottish and Portuguese cases, in whom the same highly conserved asparagine residue N114 was mutated to histidine (N114H) or aspartic acid (N114D) residues, respectively.	Histidine	192-201	keratin 86	Homo sapiens	69-73
10517800-14	1999	Systematic mutation of extracellular histidine residues in the GlyR alpha1 subunit revealed that mutations H107A or H109A completely abolished inhibition of glycine-gated currents by Zn2+.	Histidine	37-46	glycine receptor alpha 1	Homo sapiens	63-74
25505265-5	2015	We show that HHAT is comprised of ten transmembrane domains and two reentrant loops with the critical His and Asp residues on opposite sides of the endoplasmic reticulum membrane.	Histidine	102-105	hedgehog acyltransferase	Homo sapiens	13-17
10517800-18	1999	An examination of Zn2+ co-ordination in metalloenzymes revealed that the histidine- hydrophobic residue-histidine motif found to be responsible for binding Zn2+ in the human GlyR alpha1 subunit is also shared by some of these enzymes.	Histidine	73-82	glycine receptor alpha 1	Homo sapiens	174-185
25658096-3	2015	We demonstrate that these two sites are readily phosphorylated by NDR and LATS kinases in vitro, and this requires the presence of an upstream -5 histidine residue.	Histidine	146-155	serine/threonine kinase 38	Homo sapiens	66-69
10517800-18	1999	An examination of Zn2+ co-ordination in metalloenzymes revealed that the histidine- hydrophobic residue-histidine motif found to be responsible for binding Zn2+ in the human GlyR alpha1 subunit is also shared by some of these enzymes.	Histidine	104-113	glycine receptor alpha 1	Homo sapiens	174-185
10570924-4	1999	This observation suggests a novel role in proteolysis for residues of DPP IV distant from the Ser-Asp-His catalytic triad.	Histidine	102-105	dipeptidyl peptidase 4	Homo sapiens	70-76
25620968-3	2014	Two myo-inositol monophosphatase -like (IMPL) genes in Arabidopsis encode chloroplast proteins with homology to the prokaryotic IMPs and one of these, IMPL2, can complement a bacterial histidinol 1-phosphate phosphatase mutant defective in histidine synthesis, indicating an important role for IMPL2 in amino acid synthesis.	Histidine	240-249	inositol monophosphatase family protein	Arabidopsis thaliana	151-156
25620968-7	2014	Identification and characterization of impl1 and impl2 mutants revealed no viable mutants for IMPL1, while two different impl2 mutants were identified and shown to be severely compromised in growth, which can be rescued by histidine.	Histidine	223-232	inositol monophosphatase family protein	Arabidopsis thaliana	121-126
10514264-7	1999	Protein C has twelve surface-accessible histidines, which are the major metal-binding groups for IMAC separation.	Histidine	40-50	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	0-9
25620968-8	2014	Analyses of metabolite levels in impl2 and complemented mutants reveals impl2 mutant growth is impacted by alterations in the histidine biosynthesis pathway, but does not impact myo-inositol synthesis.	Histidine	126-135	inositol monophosphatase family protein	Arabidopsis thaliana	72-77
25620968-9	2014	Together, these data indicate that IMPL2 functions in the histidine biosynthetic pathway, while IMP and IMPL1 catalyze the hydrolysis of inositol- and galactose-phosphates in the plant cell.	Histidine	58-67	inositol monophosphatase family protein	Arabidopsis thaliana	35-40
10501933-0	1999	The N-end rule pathway is required for import of histidine in yeast lacking the kinesin-like protein Cin8p.	Histidine	49-58	kinesin motor protein CIN8	Saccharomyces cerevisiae S288C	101-106
25615976-1	2015	Structures of the catalytic N-acetyltransferase (NAT) domain of the bifunctional N-acetyl-L-glutamate synthase/kinase (NAGS/K) from Xylella fastidiosa bound to N-acetyl-L-glutamate (NAG) with and without an N-terminal His tag have been solved and refined at 1.7 and 1.4 A resolution, respectively.	Histidine	218-221	N-acetylglutamate synthase	Homo sapiens	119-123
10501933-5	1999	This defect in histidine uptake, exhibited by the sln2 mutant in the absence but not in the presence of Ubr1p, was traced to the gene HIP1, which encodes the histidine transporter.	Histidine	15-24	histidine permease	Saccharomyces cerevisiae S288C	134-138
10501933-9	1999	Thus, either the N-end rule pathway or Cin8p must be present for the viability-sustaining rate of histidine import in S. cerevisiae auxotrophic for histidine.	Histidine	98-107	kinesin motor protein CIN8	Saccharomyces cerevisiae S288C	39-44
10501933-9	1999	Thus, either the N-end rule pathway or Cin8p must be present for the viability-sustaining rate of histidine import in S. cerevisiae auxotrophic for histidine.	Histidine	148-157	kinesin motor protein CIN8	Saccharomyces cerevisiae S288C	39-44
25332048-3	2014	We found that XPG Asp1104His polymorphism was associated with a significantly increased CRC risk (dominant model: His/His + Asp/His vs. Asp/Asp, adjusted OR = 1.39, 95% CI = 1.14-1.69).	Histidine	25-28	ERCC excision repair 5, endonuclease	Homo sapiens	14-17
25332048-3	2014	We found that XPG Asp1104His polymorphism was associated with a significantly increased CRC risk (dominant model: His/His + Asp/His vs. Asp/Asp, adjusted OR = 1.39, 95% CI = 1.14-1.69).	Histidine	114-117	ERCC excision repair 5, endonuclease	Homo sapiens	14-17
10446428-4	1999	GPAT was expressed in Sf21 insect cells, and specific inhibitors strongly suggest that, like the Escherichia coli GPAT, the recombinant mitochondrial GPAT and the mitochondrial GPAT isoform in rat liver contain critical serine, histidine, and arginine residues.	Histidine	228-237	glycerol-3-phosphate acyltransferase, mitochondrial	Mus musculus	0-4
25332048-3	2014	We found that XPG Asp1104His polymorphism was associated with a significantly increased CRC risk (dominant model: His/His + Asp/His vs. Asp/Asp, adjusted OR = 1.39, 95% CI = 1.14-1.69).	Histidine	114-117	ERCC excision repair 5, endonuclease	Homo sapiens	14-17
10446428-4	1999	GPAT was expressed in Sf21 insect cells, and specific inhibitors strongly suggest that, like the Escherichia coli GPAT, the recombinant mitochondrial GPAT and the mitochondrial GPAT isoform in rat liver contain critical serine, histidine, and arginine residues.	Histidine	228-237	glycerol-3-phosphate acyltransferase, mitochondrial	Mus musculus	114-118
10446428-4	1999	GPAT was expressed in Sf21 insect cells, and specific inhibitors strongly suggest that, like the Escherichia coli GPAT, the recombinant mitochondrial GPAT and the mitochondrial GPAT isoform in rat liver contain critical serine, histidine, and arginine residues.	Histidine	228-237	glycerol-3-phosphate acyltransferase, mitochondrial	Mus musculus	114-118
25401070-1	2014	In this study (S)-3-hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase (H16_A0461/FadB", gene ID: 4247876) from one of two active fatty acid degradation operons of Ralstonia eutropha H16 has been heterologously expressed in Escherichia coli, purified as protein possessing a His-Tag and initially characterized.	Histidine	274-277	H16_RS08555	Ralstonia eutropha H16	50-69
10446428-4	1999	GPAT was expressed in Sf21 insect cells, and specific inhibitors strongly suggest that, like the Escherichia coli GPAT, the recombinant mitochondrial GPAT and the mitochondrial GPAT isoform in rat liver contain critical serine, histidine, and arginine residues.	Histidine	228-237	glycerol-3-phosphate acyltransferase, mitochondrial	Mus musculus	114-118
10438744-5	1999	Deletion of the high-affinity histidine permease Hip1p in His(-) strains resulted in even greater sensitivity to Cu, Co, and Ni and the requirement of an even higher level of histidine to reverse the inhibition.	Histidine	30-39	histidine permease	Saccharomyces cerevisiae S288C	49-54
25034608-8	2014	The Asp-Phe-Gly (DFG) and His-Arg-Asp (HRD) conserved kinase motif analysis showed the importance of these motifs in IRAK4 kinase activation.	Histidine	26-29	interleukin 1 receptor associated kinase 4	Homo sapiens	117-122
10387025-3	1999	Furthermore, in a physiological assay involving mouse muscle nAChR expressed in Xenopus oocytes, the His-tagged Bgtx was as effective as authentic Bgtx at blocking acetylcholine-evoked currents.	Histidine	101-104	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	61-66
25473735-10	2014	Furthermore, the increased prevalence of incomplete RBBB in the absence of cardiomyopathy suggests a selective involvement of the His-Purkinje system in FSHD.	Histidine	130-133	FSHMD1A	Homo sapiens	153-157
10206957-3	1999	Instead, a serine, histidine, and two aspartic acids are important for signal peptidase activity by the Sec11p subunit of the yeast signal peptidase complex.	Histidine	19-28	signal peptidase complex catalytic subunit SEC11	Saccharomyces cerevisiae S288C	104-110
10087163-1	1999	The ligand-binding domain of the rat vitamin D receptor (amino acids 115-423) was expressed as an amino-terminal His-tagged protein in a bacterial expression system and purified over Ni-nitrilotriacetic acid resin and a Mono S column.	Histidine	113-116	vitamin D receptor	Rattus norvegicus	37-55
24819655-5	2014	On the other hand, in the presence of L-histidine or L-arginine, [Eu(pda)2](-) exhibited intense CPL (glum ~ 0.08 for the (5)D0   (7)F1 transition at 0.10 mol dm(-3) of the amino acid), whereas quite weak CPL was observed for [Eu(bda)2](-) under the same conditions (glum &lt; 0.01).	Histidine	38-49	hephaestin	Homo sapiens	205-208
10103027-4	1999	We reconstituted the p66/p51 heterodimer from subunits coexpressed in Escherichia coli as an N-terminal fusion protein of glutathione S-transferase (GST) with p51 and a C-terminally His-tagged p66, respectively.	Histidine	182-185	DNA polymerase delta 3, accessory subunit	Homo sapiens	21-24
24728193-5	2014	We show that C. glabrata instead initializes histidine degradation via the aromatic amino acid aminotransferase Aro8.	Histidine	45-54	bifunctional 2-aminoadipate transaminase/aromatic-amino-acid:2-oxoglutarate transaminase	Saccharomyces cerevisiae S288C	112-116
24728193-6	2014	Although ARO8 is also present in S. cerevisiae and is induced by extracellular histidine, the yeast cannot use histidine as its sole nitrogen source, possibly due to growth inhibition by a downstream degradation product.	Histidine	79-88	bifunctional 2-aminoadipate transaminase/aromatic-amino-acid:2-oxoglutarate transaminase	Saccharomyces cerevisiae S288C	9-13
24728193-6	2014	Although ARO8 is also present in S. cerevisiae and is induced by extracellular histidine, the yeast cannot use histidine as its sole nitrogen source, possibly due to growth inhibition by a downstream degradation product.	Histidine	111-120	bifunctional 2-aminoadipate transaminase/aromatic-amino-acid:2-oxoglutarate transaminase	Saccharomyces cerevisiae S288C	9-13
10103027-4	1999	We reconstituted the p66/p51 heterodimer from subunits coexpressed in Escherichia coli as an N-terminal fusion protein of glutathione S-transferase (GST) with p51 and a C-terminally His-tagged p66, respectively.	Histidine	182-185	tumor protein p63	Homo sapiens	25-28
10103041-12	1999	The allergen encoded by Pen c 1 gene was expressed in Escherichia coli as a fusion protein bearing an N-terminal histidine-affinity tag.	Histidine	113-122	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	24-27
24571269-0	2014	Conserved histidine of metal transporter AtNRAMP1 is crucial for optimal plant growth under manganese deficiency at chilling temperatures.	Histidine	10-19	natural resistance-associated macrophage protein 1	Arabidopsis thaliana	41-49
10103041-12	1999	The allergen encoded by Pen c 1 gene was expressed in Escherichia coli as a fusion protein bearing an N-terminal histidine-affinity tag.	Histidine	113-122	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	28-31
24571269-9	2014	Chlorotic phenotype was associated with a histidine to tyrosine (H239Y) substitution in the allele of Hog NRAMP1.	Histidine	42-51	natural resistance-associated macrophage protein 1	Arabidopsis thaliana	106-112
10085111-12	1999	Histidine residues at positions 46 and 60 are responsible for heme ligation because the H46N- or H60N-substituted QPs3 fail to restore cytochrome b560 upon addition of hemin chloride.	Histidine	0-9	succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	Bos taurus	114-118
24970226-7	2014	XAS on HPRG isolated from the AMPD complex showed that zinc is bound to the protein in a dinuclear cluster where each Zn2+ ion is coordinated by three histidine and one heavier ligand, likely sulfur from cysteine.	Histidine	151-160	histidine rich glycoprotein	Homo sapiens	7-11
10087200-6	1999	When the presumptive active site histidine was altered to alanine by site-directed mutagenesis, enzyme activity was abolished, confirming the classification of (MMU)Minpp1 as a histidine phosphatase.	Histidine	33-42	multiple inositol-polyphosphate phosphatase 1	Homo sapiens	165-171
24817736-6	2014	The pathway is initiated by EgtD, a SAM-dependent methyltransferase that catalyzes a trimethylation reaction of histidine to give N(alpha),N(alpha),N(alpha)-trimethylhistidine.	Histidine	112-121	THUMP domain containing 2	Homo sapiens	36-67
10368279-5	1999	RESULTS: The crystal structure of a stable quadruple mutant of PAI-1(Asn150--&gt;His, Lys154--&gt;Thr, Gln319--&gt;Leu, Met354--&gt;Ile) in its active conformation has been solved at a nominal 3 A resolution.	Histidine	81-84	serpin family E member 1	Homo sapiens	63-68
24637767-4	2014	Here, full-length human RIG-I (hRIG-I) was cloned in Escherichia coli and expressed in a recombinant form with a His-SUMO tag.	Histidine	113-116	DExD/H-box helicase 58	Homo sapiens	24-29
24637767-4	2014	Here, full-length human RIG-I (hRIG-I) was cloned in Escherichia coli and expressed in a recombinant form with a His-SUMO tag.	Histidine	113-116	DExD/H-box helicase 58	Homo sapiens	31-37
10499104-4	1999	The electronic absorption and MCD spectra of the engineered K(+)-site APX mutant are essentially identical to those of cytochrome b5, a known bis-imidazole (histidine) ligated heme system.	Histidine	157-166	cytochrome b5 type A	Homo sapiens	119-132
24441828-5	2014	The introduction of metal-binding histidines at this site converts RyR2 into a luminal Ni(2+)-gated channel.	Histidine	34-44	ryanodine receptor 2, cardiac	Mus musculus	67-71
9890932-0	1999	Effect of pH on formation of a nativelike intermediate on the unfolding pathway of a Lys 73 --&gt; His variant of yeast iso-1-cytochrome c. Previous work on a Lys 73 --&gt; His (H73) variant of iso-1-cytochrome c at pH 7.5 [Godbole et al.	Histidine	99-102	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	120-125
24354269-5	2014	We found that trivalent conjugates that included both the targeting sequence and several histidine residues were substantially more effective than conjugates containing only the bombesin or histidine moieties.	Histidine	89-98	gastrin releasing peptide	Homo sapiens	178-186
10433084-2	1999	In these cells the protein was effectively expressed and ICA69 carrying C-terminal histidine-hexapeptide could be efficiently purified using immobilized metal chelate affinity chromatography.	Histidine	83-92	islet cell autoantigen 1	Homo sapiens	57-62
24917394-6	2014	Then, the in silico-based experiments established through molecular docking calculations and scoring, docking search algorithm, and data plotting indicated that ascorbic acid is strong inhibitor of tyrosinase by interacting with four amino acid units (histidine 263, serine 282, phenylalanine 264, and valin 283) in the active site of the enzyme.	Histidine	252-261	tyrosinase	Homo sapiens	198-208
24330471-9	2013	In this study, Rv2135c and Rv0489 from M. tuberculosis were cloned and expressed in Escherichia coli with 6 histidine residues tagged at the C terminal.	Histidine	108-117	hypothetical protein	Mycobacterium tuberculosis H37Rv	15-22
24349317-4	2013	We predicted a novel molecular model for ECP binding of heparin hexasaccharide (Hep6), [GlcNS(6S)-IdoA(2S)]3, and residues Gln(40), His(64) and Arg(105) were indicated as major contributions for the interaction.	Histidine	132-135	ribonuclease A family member 3	Homo sapiens	41-44
24349317-5	2013	Interestingly, Gln(40) and His(64) on ECP formed a clamp-like structure to stabilize Hep6 in our model, which was not observed in the corresponding residues on EDN.	Histidine	27-30	ribonuclease A family member 3	Homo sapiens	38-41
24349317-7	2013	Weaker binding of ECP Q40A/H64A of all heparin variants suggested that Gln(40)-His(64) clamp contributed to ECP-heparin interaction significantly.	Histidine	79-82	ribonuclease A family member 3	Homo sapiens	18-21
24349317-7	2013	Weaker binding of ECP Q40A/H64A of all heparin variants suggested that Gln(40)-His(64) clamp contributed to ECP-heparin interaction significantly.	Histidine	79-82	ribonuclease A family member 3	Homo sapiens	108-111
24129577-7	2013	Second, two glutamic acid residues located on the distal side of the loop collaborate with an invariably conserved histidine on the proximal side of the loop to suppress the pKa of an ionizing species on ubiquitin or Cdc34 which greatly contributes to Cdc34 catalysis.	Histidine	115-124	cell division cycle 34, ubiqiutin conjugating enzyme	Homo sapiens	217-222
24129577-7	2013	Second, two glutamic acid residues located on the distal side of the loop collaborate with an invariably conserved histidine on the proximal side of the loop to suppress the pKa of an ionizing species on ubiquitin or Cdc34 which greatly contributes to Cdc34 catalysis.	Histidine	115-124	cell division cycle 34, ubiqiutin conjugating enzyme	Homo sapiens	252-257
23842845-3	2013	One of such substitutions, c.2201G&gt;A in STK10 cDNA, replaces an arginine residue to a histidine (R634H) in the encoded protein.	Histidine	89-98	serine/threonine kinase 10	Homo sapiens	43-48
23733202-2	2013	XRCC1 codon 280 polymorphism is an Arg-His change in the XRCC1 gene.	Histidine	39-42	X-ray repair cross complementing 1	Homo sapiens	57-62
24043698-6	2013	http://dx.doi.org/10.1083/jcb.201308034) show that pHi increase activates FAK by causing deprotonation of histidine 58 in its FERM (band 4.1, ezrin, radixin, moesin) homology domain, which exposes a region important for FAK autophosphorylation.	Histidine	106-115	erythrocyte membrane protein band 4.1	Homo sapiens	132-140
24005034-3	2013	The immobilization of His6-RAGE domains consists of: (i) formation of a mixed layer of N-acetylcysteamine (NAC) and the thiol derivative of pentetic acid (DPTA); (ii) complexation of Cu(II) by DPTA; (iii) oriented immobilization of His6-RAGE domains via coordination bonds between Cu(II) sites from DPTA-Cu(II) complex and imidazole nitrogen atoms of a histidine tag.	Histidine	353-362	advanced glycosylation end-product specific receptor	Homo sapiens	27-31
23628156-0	2013	Structures of yeast Apa2 reveal catalytic insights into a canonical AP4A phosphorylase of the histidine triad superfamily.	Histidine	94-103	bifunctional AP-4-A phosphorylase/ADP sulfurylase	Saccharomyces cerevisiae S288C	20-24
23628156-4	2013	Apa2 is an alpha/beta protein with a core domain of a twisted eight-stranded antiparallel beta-sheet flanked by several alpha-helices, similar to the galactose-1-phosphate uridylyltransferase (GalT) members of the histidine triad (HIT) superfamily.	Histidine	214-223	bifunctional AP-4-A phosphorylase/ADP sulfurylase	Saccharomyces cerevisiae S288C	0-4
23648837-4	2013	Extensive equilibrium MD simulations with a combined length of over 8 mus demonstrate that histidine protonation, while not accompanied by the loss of structural compactness of the T-domain, nevertheless results in substantial molecular rearrangements characterized by the partial loss of secondary structure due to unfolding of helices TH1 and TH2 and the loss of close contact between the C- and N-terminal segments.	Histidine	91-100	negative elongation factor complex member C/D	Homo sapiens	337-340
23844178-4	2013	Hypomorphic mutations in histidine decarboxylase (HDC), an enzyme catalyzing the conversion from histidine to histamine, caused an increase in sleep duration.	Histidine	25-34	Histidine decarboxylase	Drosophila melanogaster	50-53
23443656-3	2013	Herein, we produced recombinant histidine-tagged Toxoplasma gondii MIF (TgMIF), a 12-kDa protein that lacks oxidoreductase activity but exhibits tautomerase activity with a specific activity of 19.3 mumol/min/mg that cannot be inhibited by the human MIF inhibitor ISO-1.	Histidine	32-41	eukaryotic translation initiation factor 1	Homo sapiens	264-269
23525108-5	2013	Stabilizing the C-helix of intact CNGA1 channels by metal binding to a pair of histidines promoted channel opening.	Histidine	79-89	cyclic nucleotide gated channel subunit alpha 1	Homo sapiens	34-39
23289972-7	2013	In these binding models, compound 1 may bind into the active site of both isoforms showing important short contacts with the peroxisome proliferator-activated receptor gamma residues: Tyr 473, His 449, Ser 289, His 323; and peroxisome proliferator-activated receptor alpha residues: Tyr 464, His 440, Ser 280 and Tyr 314.	Histidine	193-196	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	125-173
23425027-3	2013	The XRCC1 codon 280 His carriers (Arg/His+His/His) held a significantly lower risk of distant metastasis in the dominant model (Pearson chi-square test P=0.019).	Histidine	20-23	X-ray repair cross complementing 1	Homo sapiens	4-9
23425027-3	2013	The XRCC1 codon 280 His carriers (Arg/His+His/His) held a significantly lower risk of distant metastasis in the dominant model (Pearson chi-square test P=0.019).	Histidine	38-41	X-ray repair cross complementing 1	Homo sapiens	4-9
23425027-3	2013	The XRCC1 codon 280 His carriers (Arg/His+His/His) held a significantly lower risk of distant metastasis in the dominant model (Pearson chi-square test P=0.019).	Histidine	38-41	X-ray repair cross complementing 1	Homo sapiens	4-9
23425027-3	2013	The XRCC1 codon 280 His carriers (Arg/His+His/His) held a significantly lower risk of distant metastasis in the dominant model (Pearson chi-square test P=0.019).	Histidine	38-41	X-ray repair cross complementing 1	Homo sapiens	4-9
23318883-4	2013	Activation of GCN2 in primary or immortalized human hepatic stellate cells by incubation with medium lacking the essential amino acid histidine correlated with decreased levels of collagen type I protein and mRNA, suggesting an antifibrogenic effect of GCN2.	Histidine	134-143	eukaryotic translation initiation factor 2 alpha kinase 4	Homo sapiens	14-18
23220592-5	2013	The stabilities of ABH-am and BAH-am complexes are intermediate between those of strong His-3 peptides but these complexes are still able to saturate the coordination sphere of the Cu(II) ion at neutral pH.	Histidine	88-91	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	19-22
23022039-2	2013	More than one third of the mammalian PLA(2) enzymes belong to the secreted PLA(2) (sPLA(2)) family, which consists of low molecular mass, Ca(2+)-requiring enzymes with a His-Asp catalytic dyad.	Histidine	170-173	phospholipase A2 group IIA	Homo sapiens	83-90
23135388-0	2013	Heme orientation modulates histidine dissociation and ligand binding kinetics in the hexacoordinated human neuroglobin.	Histidine	27-36	neuroglobin	Homo sapiens	107-118
22367578-7	2012	The resulting L-histidine may subsequently be converted into histamine, which could be responsible for the effects of CAR on neurotransmission and physiological function.	Histidine	14-25	nuclear receptor subfamily 1, group I, member 3	Rattus norvegicus	118-121
22773744-9	2012	Site-directed mutagenesis showed that CER1 His clusters are essential for alkane synthesis, whereas those of CER3 are not, suggesting that CYTB5s are specific CER1 cofactors.	Histidine	43-46	Hsp70 family chaperone LHS1	Saccharomyces cerevisiae S288C	38-42
22437839-8	2012	The glutamate-histidine substitution prevents a 3-ketosteroid from penetrating the active site so that hydride transfer is directed toward the C3 carbonyl group rather than the Delta(4)-double bond and confers 3beta-HSD activity on the 5beta-reductase.	Histidine	14-23	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	210-219
22486179-1	2012	We use a host-guest approach to evaluate the effect of Trp guest residues relative to Ala on the kinetics and thermodynamics of formation of His-heme loops in the denatured state of iso-1-cytochrome c at 1.5, 3.0, and 6.0 M guanidine hydrochloride (GdnHCl).	Histidine	141-144	eukaryotic translation initiation factor 1	Homo sapiens	182-187
22486179-2	2012	Trp guest residues are inserted into an alanine-rich segment placed after a unique His near the N-terminus of iso-1-cytochrome c.	Histidine	83-86	eukaryotic translation initiation factor 1	Homo sapiens	110-115
22391343-3	2012	The mutation (CAT  CGT), which has occurred at codon 151, at nucleotide position 524, implies an amino acidic change from Histidine to Arginine.	Histidine	122-131	UDP glycosyltransferase 8	Homo sapiens	19-22
22509914-3	2012	The present study describes the production of a human anti-GPA monoclonal antibody and its purification using a pseudo-bioaffinity L-histidine-convective interaction media (CIM) monolithic column.	Histidine	131-142	glycophorin A	Mus musculus	59-62
22469241-0	2012	Single-photon emission computed tomographic imaging of the early time course of therapy-induced cell death using technetium 99m tricarbonyl His-annexin A5 in a colorectal cancer xenograft model.	Histidine	140-143	annexin A5	Mus musculus	144-154
22469241-1	2012	As apoptosis occurs over an interval of time after administration of apoptosis-inducing therapy in tumors, the changes in technetium 99m ((99m)Tc)-tricarbonyl (CO)3 His-annexin A5 (His-ann A5) accumulation over time were examined.	Histidine	165-168	annexin A5	Mus musculus	169-179
22469241-1	2012	As apoptosis occurs over an interval of time after administration of apoptosis-inducing therapy in tumors, the changes in technetium 99m ((99m)Tc)-tricarbonyl (CO)3 His-annexin A5 (His-ann A5) accumulation over time were examined.	Histidine	181-184	annexin A5	Mus musculus	169-179
22590679-5	2012	However, when dialyzed together with Gst-gp3 or with Gst-gp4, His-gp2b and His-gp4 remain soluble and oligomers are obtained by affinity-chromatography.	Histidine	62-65	integrin subunit alpha 2b	Homo sapiens	66-70
22919744-5	2012	RESULTS: The recombinant protein 6 x His-VP2 was produced in a larger quantity at 25 degrees C induced by IPTG (1 mmol/L) over night and purified by Ni-NTA column.	Histidine	37-40	VP2	Primate bocaparvovirus 1	41-44
22139846-6	2012	Expression of HvMTP1/AtMTP1 chimeras in yeast revealed a five-residue sequence within the AtMTP1 N-segment of the His-rich intracytoplasmic loop that confines specificity to Zn(2+).	Histidine	114-117	putative Zn transporter	Hordeum vulgare	14-20
22904671-6	2012	Each monomer of the Aqy1 tetramers forms a channel whose walls consist mostly of hydrophilic residues, transporting through the selectivity filter containing Arg-227, His-212, Phe-92, and Ala-221, and the two conserved Asn-Pro-Ala (NPA) motifs containing asparagines 224 and 112.	Histidine	167-170	Aqy1p	Saccharomyces cerevisiae S288C	20-24
23028758-1	2012	In humans and mice, the Cys(2)His(2) zinc finger protein PRDM9 binds to a DNA sequence motif enriched in hotspots of recombination, possibly modifying nucleosomes, and recruiting recombination machinery to initiate Double Strand Breaks (DSBs).	Histidine	30-33	PR domain containing 9	Mus musculus	57-62
23028834-4	2012	To gain insight into these interfaces, we used the process of genome-rewiring in yeast by placing an essential metabolic gene HIS3 from the histidine biosynthesis pathway, under the exclusive regulation of different cell-cycle promoters.	Histidine	140-149	imidazoleglycerol-phosphate dehydratase HIS3	Saccharomyces cerevisiae S288C	126-130
23028834-5	2012	In a medium lacking histidine and under partial inhibition of the HIS3p, the rewired cells encountered an unforeseen multitasking challenge; the cell-cycle regulatory genes were required to regulate the essential histidine-pathway gene in concert with the other metabolic demands, while simultaneously driving the cell cycle through its proper temporal phases.	Histidine	213-222	imidazoleglycerol-phosphate dehydratase HIS3	Saccharomyces cerevisiae S288C	66-71
23028501-6	2012	We show that many translocation-prone pairs of regions genome-wide, including the cancer translocation partners BCR-ABL and MYC-IGH, display elevated Hi-C contact frequencies in normal human cells.	Histidine	150-152	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	112-119
21990358-0	2011	Reversible major histocompatibility complex I-peptide multimers containing Ni(2+)-nitrilotriacetic acid peptides and histidine tags improve analysis and sorting of CD8(+) T cells.	Histidine	117-126	CD8a molecule	Homo sapiens	164-167
21950469-1	2011	We had previously reported that Mitsunobu-based introduction of alkyl substituents onto the imidazole N(pi)-position of a key histidine residue in phosphothreonine-containing peptides can impart high binding affinity against the polo-box domain of polo-like kinase 1.	Histidine	126-135	polo like kinase 1	Homo sapiens	248-266
21950761-5	2011	We have developed a new approach to systematically identify the substrates of ubiquitin ligases by identifying proteins that display an enhanced incorporation of His-tagged ubiquitin upon ligase coexpression; using this method, we identified several candidate substrates for BRCA1.	Histidine	162-165	BRCA1 DNA repair associated	Homo sapiens	275-280
21864500-2	2011	To complement structural information available, we produced the FAD-containing monooxygenase-like domain of human MICAL-1 (MICAL-MO) in forms differing for the presence and location of a His-tag, which only influences the protein yields.	Histidine	187-190	microtubule associated monooxygenase, calponin and LIM domain containing 1	Homo sapiens	114-121
21864500-2	2011	To complement structural information available, we produced the FAD-containing monooxygenase-like domain of human MICAL-1 (MICAL-MO) in forms differing for the presence and location of a His-tag, which only influences the protein yields.	Histidine	187-190	microtubule associated monooxygenase, calponin and LIM domain containing 1	Homo sapiens	114-119
21892195-5	2011	We constructed plasmid pET28a (+)-His(6)-tobacco etch virus (TEV)-eppin for expression in Escherichia coli.	Histidine	34-37	epididymal peptidase inhibitor	Mus musculus	66-71
21895659-1	2011	beta-Lactotensin (His-Ile-Arg-Leu) is a bioactive peptide derived from bovine milk beta-lactoglobulin, acting as a natural agonist for neurotensin receptors.	Histidine	18-21	beta-lactoglobulin	Bos taurus	83-101
22045708-10	2011	SPECT analyses demonstrated a significant increase in tumoral (99m)Tc-(CO)(3) His-annexin A5 uptake 4 d after bevacizumab treatment and 24 h after irinotecan administration (232.78 +- 24.82 percentage injected dose/tumor weight [g]/body weight [kg], P &lt; 0.05), compared with each monotherapy, indicating a synergistic effect of both therapies.	Histidine	78-81	annexin A5	Mus musculus	82-92
22045708-11	2011	CONCLUSION: (99m)Tc-(CO)(3) His-annexin A5 micro-SPECT demonstrates increased antitumor activity of irinotecan during the transient vascular normalization period caused by bevacizumab.	Histidine	28-31	annexin A5	Mus musculus	32-42
9854036-4	1999	Mouse GSTT1-1 was expressed in Escherichia coli as an N-terminal 6x histidine-tagged protein and purified using immobilized-metal affinity chromatography on nickel-agarose.	Histidine	68-77	glutathione S-transferase, theta 1	Mus musculus	6-13
21824479-4	2011	We present here the structures of MPPED2 and two mutants, which show that the poor activity of MPPED2 is not only a consequence of the substitution of an active-site histidine residue by glycine but also due to binding of AMP or GMP to the active site.	Histidine	166-175	metallophosphoesterase domain containing 2	Homo sapiens	34-40
21824479-4	2011	We present here the structures of MPPED2 and two mutants, which show that the poor activity of MPPED2 is not only a consequence of the substitution of an active-site histidine residue by glycine but also due to binding of AMP or GMP to the active site.	Histidine	166-175	metallophosphoesterase domain containing 2	Homo sapiens	95-101
9882662-6	1999	The homologous genes (uppS) were cloned from E. coli, Haemophilus influenzae, and Streptococcus pneumoniae, expressed in E. coli as amino-terminal His-tagged fusion proteins, and purified over a Ni2+ affinity column.	Histidine	147-150	uppS	Streptococcus pneumoniae R6	22-26
10025663-0	1999	Receptor recognition by histidine 16 of human epidermal growth factor via hydrogen-bond donor/acceptor interactions.	Histidine	24-33	epidermal growth factor	Homo sapiens	46-69
21682270-3	2011	More importantly, in contrast to the reported nuclear stains that are based on luminescence enhancement through interaction with nucleic acids, complex LIr1 as a nuclear stain has a reaction-based mode of action, which relies on its rapid reaction with histidine/histidine-containing proteins.	Histidine	253-262	leukocyte immunoglobulin like receptor B1	Homo sapiens	152-156
9852079-0	1998	Affinity purification and partial characterization of a yeast multiprotein complex for nucleotide excision repair using histidine-tagged Rad14 protein.	Histidine	120-129	DNA repair protein RAD14	Saccharomyces cerevisiae S288C	137-142
21682270-3	2011	More importantly, in contrast to the reported nuclear stains that are based on luminescence enhancement through interaction with nucleic acids, complex LIr1 as a nuclear stain has a reaction-based mode of action, which relies on its rapid reaction with histidine/histidine-containing proteins.	Histidine	263-272	leukocyte immunoglobulin like receptor B1	Homo sapiens	152-156
9852079-4	1998	To examine this model further, we have constructed a histidine-tagged version of the yeast DNA damage recognition protein Rad14.	Histidine	53-62	DNA repair protein RAD14	Saccharomyces cerevisiae S288C	122-127
21765407-1	2011	We obtained unanticipated synthetic byproducts from alkylation of the delta(1) nitrogen (N3) of the histidine imidazole ring of the polo-like kinase-1 (Plk1) polo-box domain (PBD)-binding peptide PLHSpT.	Histidine	100-109	polo like kinase 1	Homo sapiens	132-150
9837973-8	1998	Rat FTCD is structurally similar to porcine FTCD, a metabolic enzyme involved in conversion of histidine to glutamic acid, and exists in dimeric, tetrameric, and octameric complexes resistant to proteolysis.	Histidine	95-104	formimidoyltransferase cyclodeaminase	Rattus norvegicus	4-8
21765407-1	2011	We obtained unanticipated synthetic byproducts from alkylation of the delta(1) nitrogen (N3) of the histidine imidazole ring of the polo-like kinase-1 (Plk1) polo-box domain (PBD)-binding peptide PLHSpT.	Histidine	100-109	polo like kinase 1	Homo sapiens	152-156
9837973-8	1998	Rat FTCD is structurally similar to porcine FTCD, a metabolic enzyme involved in conversion of histidine to glutamic acid, and exists in dimeric, tetrameric, and octameric complexes resistant to proteolysis.	Histidine	95-104	formimidoyltransferase cyclodeaminase	Rattus norvegicus	44-48
24250389-10	2011	The yield of hepcidin in BES was 20 mug/mL and anti-histidine (anti-His) tag antibody was used for the confirmation of hepcidin on western blot nitrocellulose paper.	Histidine	52-61	hepcidin antimicrobial peptide	Mus musculus	119-127
9839942-0	1998	The role of distal histidine in peroxidase activity of myoglobin--transient-kinetics study of the reaction of H2O2 with wild-type and distal-histidine-mutanted recombinant human myoglobin.	Histidine	19-28	myoglobin	Homo sapiens	55-64
24250389-10	2011	The yield of hepcidin in BES was 20 mug/mL and anti-histidine (anti-His) tag antibody was used for the confirmation of hepcidin on western blot nitrocellulose paper.	Histidine	68-71	hepcidin antimicrobial peptide	Mus musculus	119-127
9839942-0	1998	The role of distal histidine in peroxidase activity of myoglobin--transient-kinetics study of the reaction of H2O2 with wild-type and distal-histidine-mutanted recombinant human myoglobin.	Histidine	141-150	myoglobin	Homo sapiens	55-64
9839942-0	1998	The role of distal histidine in peroxidase activity of myoglobin--transient-kinetics study of the reaction of H2O2 with wild-type and distal-histidine-mutanted recombinant human myoglobin.	Histidine	141-150	myoglobin	Homo sapiens	178-187
21398639-7	2011	Placing the SAE3 and PCH2 introns within a HIS3 reporter confers Tgs1-dependent histidine prototrophy, signifying that the respective introns are portable determinants of TMG-dependent gene expression.	Histidine	80-89	Sae3p	Saccharomyces cerevisiae S288C	12-16
9839942-3	1998	The effect of mutation of the distal histidine on the peroxidase activity of Mb has been investigated by stopped-flow kinetics of the reaction of hydrogen peroxide with wild-type Mb and [Gly64]Mb.	Histidine	37-46	myoglobin	Homo sapiens	77-79
21398639-7	2011	Placing the SAE3 and PCH2 introns within a HIS3 reporter confers Tgs1-dependent histidine prototrophy, signifying that the respective introns are portable determinants of TMG-dependent gene expression.	Histidine	80-89	imidazoleglycerol-phosphate dehydratase HIS3	Saccharomyces cerevisiae S288C	43-47
9839942-5	1998	The rate of reaction of H2O2 with the wild-type Mb decreased 8-9-fold on mutation of the distal histidine to glycine ([Gly64]Mb).	Histidine	96-105	myoglobin	Homo sapiens	48-50
9839942-5	1998	The rate of reaction of H2O2 with the wild-type Mb decreased 8-9-fold on mutation of the distal histidine to glycine ([Gly64]Mb).	Histidine	96-105	myoglobin	Homo sapiens	125-127
9748314-1	1998	Histidine-63, one of the heme axial ligands in outer mitochondrial membrane cytochrome b5 (OM cyt b5) has been replaced by a methionine.	Histidine	0-9	cytochrome b5 type A	Homo sapiens	76-89
21296891-5	2011	Replacement of the distal histidine by leucine or glutamine leads to a stable five-coordinated geometry; these neuroglobin mutants reduce nitrite to NO ~2000 times faster than the wild type, whereas mutation of either Cys-55 or Cys-46 to alanine stabilizes the six-coordinate structure and slows the reaction.	Histidine	26-35	neuroglobin	Homo sapiens	111-122
21563332-0	2004	(111)In-DOTA-4-amino-1-carboxymethyl-piperidine-D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2 The amphibian bombesin (BBN or BN, a peptide of 14 amino acids) is an analog of human gastrin-releasing peptide (GRP, a peptide of 27 amino acids) that binds to GRP receptor (GRPR) with high affinity and specificity (1).	Histidine	74-77	gastrin releasing peptide	Homo sapiens	104-112
21563332-0	2004	(111)In-DOTA-4-amino-1-carboxymethyl-piperidine-D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2 The amphibian bombesin (BBN or BN, a peptide of 14 amino acids) is an analog of human gastrin-releasing peptide (GRP, a peptide of 27 amino acids) that binds to GRP receptor (GRPR) with high affinity and specificity (1).	Histidine	74-77	gastrin releasing peptide	Homo sapiens	176-201
21563332-0	2004	(111)In-DOTA-4-amino-1-carboxymethyl-piperidine-D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2 The amphibian bombesin (BBN or BN, a peptide of 14 amino acids) is an analog of human gastrin-releasing peptide (GRP, a peptide of 27 amino acids) that binds to GRP receptor (GRPR) with high affinity and specificity (1).	Histidine	74-77	gastrin releasing peptide	Homo sapiens	203-206
9730818-8	1998	These results show that NO binding to sGC not only leads to the cleavage of the Fe-His bond but also induces a conformational change which opens the heme proximal pocket large enough to accommodate an exogenous imidazole molecule.	Histidine	83-86	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	38-41
21343298-8	2011	The E-loop of Nox4 but not Nox1 and Nox2 contains a highly conserved histidine that could serve as a source for protons to accelerate spontaneous dismutation of superoxide to form H(2)O(2).	Histidine	69-78	cytochrome b-245 beta chain	Homo sapiens	36-40
21428382-0	2011	Histidine E7 dynamics modulates ligand exchange between distal pocket and solvent in AHb1 from Arabidopsis thaliana.	Histidine	0-9	hemoglobin 1	Arabidopsis thaliana	85-89
21428382-6	2011	Overall, these findings provide evidence supporting the functional implications of the conformational rearrangement found for the distal His in AHb1, which mimics the gating role proposed for the same residue in myoglobin.	Histidine	137-140	hemoglobin 1	Arabidopsis thaliana	144-148
9741684-4	1998	Recombinant, purified histidine-tagged protein exhibited the enzymatic properties associated with GGPP synthase, namely the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate.	Histidine	22-31	geranylgeranyl diphosphate synthase 1	Homo sapiens	98-111
9807817-5	1998	The interaction between AtFKBP12 and AtFIP37 in the 2-hybrid system, as assessed by histidine auxotrophy and beta-galactosidase activity, was disrupted by FK506, but not by cyclosporin A, a drug that binds to cyclophilin A.	Histidine	84-93	FK506-binding protein 12	Arabidopsis thaliana	24-32
20888915-1	2011	When the 34 kDa kinase domain of human spleen tyrosine kinase (Syk-KD) was expressed as a C-terminally His-tagged protein in baculovirus-infected Sf-21 insect cells, the purified protein included two forms that migrated slightly differently in SDS-polyacrylamide gel electrophoresis.	Histidine	103-106	spleen associated tyrosine kinase	Homo sapiens	63-66
9765616-6	1998	Only one Fe-NTA-induced RCC of grade 1 revealed missense mutations with loss of heterozygosity in exon 10 of the Tsc2 gene (codons 334, GTG (Val) to GCG (Ala), and 336, TAT (Tyr) to CAT (His).	Histidine	187-190	TSC complex subunit 2	Rattus norvegicus	113-117
20937357-2	2011	Previously we have found that a C-terminal His(6)-tag destroys the bioactivity of growth differentiation-9 (GDF9, a homolog of BMP15).	Histidine	43-46	growth differentiation factor 9	Homo sapiens	82-106
20937357-2	2011	Previously we have found that a C-terminal His(6)-tag destroys the bioactivity of growth differentiation-9 (GDF9, a homolog of BMP15).	Histidine	43-46	growth differentiation factor 9	Homo sapiens	108-112
21290626-0	2004	3-Cyano-4-[(18)F]fluoro-benzoyl-Arg-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2 3-Cyano-4-[(18)F]fluoro-benzoyl-Arg-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2, abbreviated as [(18)F]6b, is a bombesin (BN)-based (18)F-labeled peptide synthesized by Mu et al.	Histidine	63-66	gastrin releasing peptide	Homo sapiens	190-198
9749675-7	1998	In addition, when His-90 in IIA(Glc) was replaced by glutamine, both phosphorylation of IIA(Glc) and the overproduction of cAMP in crp cells were eliminated.	Histidine	18-21	colicin Ia immunity protein	Escherichia coli	28-31
21290626-0	2004	3-Cyano-4-[(18)F]fluoro-benzoyl-Arg-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2 3-Cyano-4-[(18)F]fluoro-benzoyl-Arg-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2, abbreviated as [(18)F]6b, is a bombesin (BN)-based (18)F-labeled peptide synthesized by Mu et al.	Histidine	142-145	gastrin releasing peptide	Homo sapiens	190-198
21290627-0	2004	3-Cyano-4-[(18)F]fluoro-benzoyl-Ala(SO3H)-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2 3-Cyano-4-[(18)F]fluoro-benzoyl-Ala(SO3H)-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2, abbreviated as [(18)F]7b, is a bombesin (BN)-based (18)F-labeled peptide synthesized by Mu et al.	Histidine	69-72	gastrin releasing peptide	Homo sapiens	202-210
9749675-7	1998	In addition, when His-90 in IIA(Glc) was replaced by glutamine, both phosphorylation of IIA(Glc) and the overproduction of cAMP in crp cells were eliminated.	Histidine	18-21	colicin Ia immunity protein	Escherichia coli	88-91
9742571-4	1998	Molecular analysis of the affected son revealed a G to A mutation in codon 156 of keratin 10, resulting in an arginine to histidine substitution within the highly conserved 1A region.	Histidine	122-131	keratin 10	Homo sapiens	82-92
20978135-3	2011	We have previously shown that Fra2 and Grx3/4 form a [2Fe-2S](2+)-bridged heterodimeric complex with iron ligands provided by the active site cysteine of Grx3/4, glutathione, and a histidine residue.	Histidine	181-190	Bol2p	Saccharomyces cerevisiae S288C	30-34
20978135-3	2011	We have previously shown that Fra2 and Grx3/4 form a [2Fe-2S](2+)-bridged heterodimeric complex with iron ligands provided by the active site cysteine of Grx3/4, glutathione, and a histidine residue.	Histidine	181-190	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	39-43
20978135-3	2011	We have previously shown that Fra2 and Grx3/4 form a [2Fe-2S](2+)-bridged heterodimeric complex with iron ligands provided by the active site cysteine of Grx3/4, glutathione, and a histidine residue.	Histidine	181-190	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	154-158
20978135-5	2011	Here, we present spectroscopic evidence that His-103 in Fra2 is an Fe-S cluster ligand in the Fra2-Grx3 complex.	Histidine	45-48	Bol2p	Saccharomyces cerevisiae S288C	56-60
9671798-3	1998	Among the proton-sucrose symporters cloned to date, only the histidine residue at position 65 of AtSUC1 from Arabidopsis thaliana is conserved across species.	Histidine	61-70	sucrose-proton symporter 1	Arabidopsis thaliana	97-103
20978135-5	2011	Here, we present spectroscopic evidence that His-103 in Fra2 is an Fe-S cluster ligand in the Fra2-Grx3 complex.	Histidine	45-48	Bol2p	Saccharomyces cerevisiae S288C	94-98
20978135-5	2011	Here, we present spectroscopic evidence that His-103 in Fra2 is an Fe-S cluster ligand in the Fra2-Grx3 complex.	Histidine	45-48	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	99-103
20978135-7	2011	In vivo genetic studies further confirm that Fra2 His-103 is critical for control of Aft1 activity in response to the cellular iron status.	Histidine	50-53	Bol2p	Saccharomyces cerevisiae S288C	45-49
20978135-7	2011	In vivo genetic studies further confirm that Fra2 His-103 is critical for control of Aft1 activity in response to the cellular iron status.	Histidine	50-53	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	85-89
20978135-9	2011	Taken together, these results demonstrate that the histidine coordination and stability of the [2Fe-2S] cluster in the Fra2-Grx3 complex are essential for iron regulation in yeast.	Histidine	51-60	Bol2p	Saccharomyces cerevisiae S288C	119-123
20978135-9	2011	Taken together, these results demonstrate that the histidine coordination and stability of the [2Fe-2S] cluster in the Fra2-Grx3 complex are essential for iron regulation in yeast.	Histidine	51-60	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	124-128
9655916-1	1998	Basic amino acids Arg, Lys, and His in the Cys2His2 zinc fingers of transcription factor IIIA (TFIIIA) potentially have important roles in factor binding to the extended internal control region (ICR) of the 5S ribosomal gene.	Histidine	32-35	general transcription factor 3A L homeolog	Xenopus laevis	68-93
9655916-1	1998	Basic amino acids Arg, Lys, and His in the Cys2His2 zinc fingers of transcription factor IIIA (TFIIIA) potentially have important roles in factor binding to the extended internal control region (ICR) of the 5S ribosomal gene.	Histidine	32-35	general transcription factor 3A L homeolog	Xenopus laevis	95-101
22191059-4	2011	Asp1 does not bind to Cu(II) if three His residues are attached nor to any Cu(I) species to which one or more His residues are bound.	Histidine	38-41	beta-secretase 2	Homo sapiens	0-4
22191059-4	2011	Asp1 does not bind to Cu(II) if three His residues are attached nor to any Cu(I) species to which one or more His residues are bound.	Histidine	110-113	beta-secretase 2	Homo sapiens	0-4
9632755-4	1998	Affinity isolation of histidine-tagged Sba1p (Sba1(His6)) after expression in yeast led to coisolation of Hsp90 and the cyclophilin homolog Cpr6.	Histidine	22-31	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	106-111
21673902-2	2011	More than one third of the PLA(2) enzymes belong to the secreted PLA(2) (sPLA(2)) family, which consists of low-molecular-weight, Ca(2+)-requiring extracellular enzymes, with a His-Asp catalytic dyad.	Histidine	177-180	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	27-32
9494086-3	1998	The histidine-tagged human green cone pigment was functionally expressed in large-scale suspension cultures in Sf9 insect cells using recombinant baculovirus.	Histidine	4-13	opsin 1, medium wave sensitive	Homo sapiens	27-45
9502416-8	1998	Amino-terminal sequence analysis of the protein revealed a Gly-Pro-Ala-Lys-Ser-Pro-Tyr-Gln-Leu-Val-Leu-Gln-His-Ser-Arg sequence indistinguishable from an amino-terminal protein sequence deduced from a cDNA clone designated beta ig-h3, and it as well as the abnormal accumulations in GCD cross-reacted with beta ig-h3 antiserum.	Histidine	107-110	guanylate cyclase 2E, pseudogene	Homo sapiens	283-286
21673902-2	2011	More than one third of the PLA(2) enzymes belong to the secreted PLA(2) (sPLA(2)) family, which consists of low-molecular-weight, Ca(2+)-requiring extracellular enzymes, with a His-Asp catalytic dyad.	Histidine	177-180	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	27-33
21673902-2	2011	More than one third of the PLA(2) enzymes belong to the secreted PLA(2) (sPLA(2)) family, which consists of low-molecular-weight, Ca(2+)-requiring extracellular enzymes, with a His-Asp catalytic dyad.	Histidine	177-180	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	73-80
9734335-6	1998	Aminopeptidase Ey contains the metallo-binding sequence motif, His-Glu-Xaa-His, found in zinc metallopeptidases.	Histidine	63-66	alanyl aminopeptidase, membrane	Gallus gallus	0-17
21059758-3	2011	Using site-directed mutagenesis and metal chelators such as diethylenetriamine pentaacetic acid and deferoxamine, we reveal that a unique histidine at position 191 of CaV3.2 participates in a critical metal binding site, which may in turn interact with N2O to produce reactive oxygen species (ROS).	Histidine	138-147	calcium channel, voltage-dependent, T type, alpha 1H subunit	Mus musculus	167-173
9734335-6	1998	Aminopeptidase Ey contains the metallo-binding sequence motif, His-Glu-Xaa-His, found in zinc metallopeptidases.	Histidine	75-78	alanyl aminopeptidase, membrane	Gallus gallus	0-17
9457881-2	1998	To elucidate the specific role of IIA(Glc) phosphorylation in the regulation of adenylyl cyclase activity, both the phosphorylatable histidine (H90) and the interactive histidine (H75) of IIA(Glc) were mutated by site-directed mutagenesis to glutamine and glutamate.	Histidine	133-142	colicin Ia immunity protein	Escherichia coli	34-37
20980517-3	2011	We identified here three residues in the shared domain of the P and V proteins-tyrosine 110, valine 112, and histidine 115-that function to retain STAT1 in the cytoplasm and inhibit interferon transcription.	Histidine	109-118	signal transducer and activator of transcription 1	Homo sapiens	147-152
21980421-3	2011	Currently, Glu314, Ser346, Lys347 and Lys362 in human c-NADP-ME were changed to the corresponding residues of human m-NAD(P)-ME (Glu, Lys, Tyr and Gln, respectively) or Ascaris suum m-NAD-ME (Ala, Ile, Asp and His, respectively).	Histidine	210-213	malic enzyme 1	Homo sapiens	56-63
9463486-7	1998	Enzymatically active hST1B2 was expressed in the bacterial expression vector pKK233-2 for kinetic characterization and in the bacterial expression vector pQE-31, which generates a histidine-tagged fusion protein for the generation of antibodies.	Histidine	180-189	sulfotransferase family 1B member 1	Homo sapiens	21-27
21157980-5	2010	RESULTS: Individuals with ADH1B arginine (Arg)/Arg genotype showed 3.95-fold increased ESCC risk in the recessive genetic model [Arg/Arg vs Arg/histidine (His) + His/His: odds ratio (OR) = 3.95, 95% confidence interval (CI): 2.76-5.67].	Histidine	144-153	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	26-31
9436819-4	1997	Two weeks after angioplasty, vascular ACE activity of the angioplasty subgroup was significantly higher than that of the nonangioplasty subgroup (from 0.44 to 1.19 nmol His-Leu/mg/min; p &lt; 0.01).	Histidine	169-172	angiotensin-converting enzyme	Oryctolagus cuniculus	38-41
21157980-5	2010	RESULTS: Individuals with ADH1B arginine (Arg)/Arg genotype showed 3.95-fold increased ESCC risk in the recessive genetic model [Arg/Arg vs Arg/histidine (His) + His/His: odds ratio (OR) = 3.95, 95% confidence interval (CI): 2.76-5.67].	Histidine	155-158	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	26-31
21157980-5	2010	RESULTS: Individuals with ADH1B arginine (Arg)/Arg genotype showed 3.95-fold increased ESCC risk in the recessive genetic model [Arg/Arg vs Arg/histidine (His) + His/His: odds ratio (OR) = 3.95, 95% confidence interval (CI): 2.76-5.67].	Histidine	162-165	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	26-31
21157980-5	2010	RESULTS: Individuals with ADH1B arginine (Arg)/Arg genotype showed 3.95-fold increased ESCC risk in the recessive genetic model [Arg/Arg vs Arg/histidine (His) + His/His: odds ratio (OR) = 3.95, 95% confidence interval (CI): 2.76-5.67].	Histidine	162-165	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	26-31
9359858-1	1997	Met-157 in the active site of human glyoxalase I was changed by site-directed mutagenesis into alanine, glutamine or histidine in order to evaluate its possible role in catalysis.	Histidine	117-126	glyoxalase I	Homo sapiens	36-48
20801892-4	2010	TRV120027 (Sar-Arg-Val-Tyr-Ile-His-Pro-D-Ala-OH) competitively antagonizes angiotensin II-stimulated G protein signaling, but stimulates beta-arrestin recruitment and activates several kinase pathways, including p42/44 mitogen-activated protein kinase, Src, and endothelial nitric-oxide synthase phosphorylation via beta-arrestin coupling.	Histidine	31-34	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	253-256
20667476-7	2010	To this end, we developed procedures for higher level expression in insect cells of active recombinant CHK with a hexa-histidine tag attached to its C-terminus (referred to as CHK-His(6)) and its rapid purification by a two-step method.	Histidine	180-183	megakaryocyte-associated tyrosine kinase	Homo sapiens	103-106
20667476-7	2010	To this end, we developed procedures for higher level expression in insect cells of active recombinant CHK with a hexa-histidine tag attached to its C-terminus (referred to as CHK-His(6)) and its rapid purification by a two-step method.	Histidine	180-183	megakaryocyte-associated tyrosine kinase	Homo sapiens	176-179
9265630-4	1997	Homology searches using the 10 amino acid sequence SxHxxGxAxD, in which histidine and aspartate residues are putative zinc ligands, identified the metal coordinating ligands in the N-terminal domain of the murine Sonic hedgehog protein, which also exhibits an architecture for metal coordination identical to that observed in thermolysin from Bacillus thermoproteolyticus.	Histidine	72-81	sonic hedgehog	Mus musculus	213-235
20667476-8	2010	Analyses by size-exclusion column chromatography and analytical ultracentrifugation revealed that the purified CHK-His(6) exists as a monomeric species in solution.	Histidine	115-118	megakaryocyte-associated tyrosine kinase	Homo sapiens	111-114
20667476-9	2010	Biochemical analyses demonstrated that CHK-His(6) exhibits efficiencies comparable to those of CSK in phosphorylating artificial protein and peptide substrates as well as an intact SFK protein.	Histidine	43-46	megakaryocyte-associated tyrosine kinase	Homo sapiens	39-42
20667476-10	2010	Our results indicate that the recombinant CHK-His(6) can be used for future studies to decipher the three-dimensional structure, and regulatory and catalytic properties of CHK.	Histidine	46-49	megakaryocyte-associated tyrosine kinase	Homo sapiens	42-45
20667476-10	2010	Our results indicate that the recombinant CHK-His(6) can be used for future studies to decipher the three-dimensional structure, and regulatory and catalytic properties of CHK.	Histidine	46-49	megakaryocyte-associated tyrosine kinase	Homo sapiens	172-175
21138690-7	2010	The enzymatic activity of purified His-tag ALT2 is over 10 000 U/L.	Histidine	35-38	glutamic--pyruvic transaminase 2	Homo sapiens	43-47
9268342-5	1997	In the present study, we show that LysoPLA I represents a new member of the serine hydrolase family with Ser-119, Asp-174, and His-208 composing the catalytic triad.	Histidine	127-130	lysophospholipase 1	Mus musculus	35-44
9268342-6	1997	The Asp-174 and His-208 are conserved among several esterases and are demonstrated herein to be essential for LysoPLA I activity as the mutation of either residue to Ala abolished LysoPLA I activity, whereas the global conformation of the mutants remained unchanged.	Histidine	16-19	lysophospholipase 1	Mus musculus	110-119
9268342-6	1997	The Asp-174 and His-208 are conserved among several esterases and are demonstrated herein to be essential for LysoPLA I activity as the mutation of either residue to Ala abolished LysoPLA I activity, whereas the global conformation of the mutants remained unchanged.	Histidine	16-19	lysophospholipase 1	Mus musculus	180-189
9242632-7	1997	The putative catalytic site histidine residue present in the inner core domains of all dihydrolipoamide acyltransferases is replaced by a serine residue in human E3BP; thus, catalysis of coenzyme A acetylation by this protein is unlikely.	Histidine	28-37	pyruvate dehydrogenase complex component X	Homo sapiens	162-166
20939030-0	2010	Detection and identification of protein-phosphorylation sites in histidines through HNP correlation patterns.	Histidine	65-75	kallikrein related peptidase 8	Homo sapiens	84-87
21055628-13	2010	CONCLUSION: [(99m)Tc]-(CO)(3) His-annexin A5 may be a useful novel radioligand for the in vivo detection of cell death associated with PS expression.	Histidine	30-33	annexin A5	Mus musculus	34-44
9242668-7	1997	Only hMOR-his was expressed at a level allowing binding study, but no difference could be detected in the affinities of both agonists and antagonists compared with the nontagged protein.	Histidine	10-13	opioid receptor mu 1	Homo sapiens	5-9
9268679-1	1997	A method for expression and purification of active cytosolic heterodimeric histidine (His)-tagged guanylyl cyclase of the alpha 1/beta 1 isoform has been developed using recombinant baculovirus-transfected insect cells.	Histidine	75-84	adrenoceptor alpha 1D	Homo sapiens	122-129
21085509-3	2010	Previously, in our group, amino acid based amphiphiles i.e. Gly-Gly-His-EO2-Alk, a trimodular amphiphile (containing three domains: H-bond donor and acceptor/hydrophilic/hydrophobic domain, respectively) were reported to act as hydrogelators and that the gelation properties were related to hydrogen bonding, hydrophobic interactions and pi-pi stacking.	Histidine	68-71	ALK receptor tyrosine kinase	Homo sapiens	76-79
9268679-1	1997	A method for expression and purification of active cytosolic heterodimeric histidine (His)-tagged guanylyl cyclase of the alpha 1/beta 1 isoform has been developed using recombinant baculovirus-transfected insect cells.	Histidine	86-89	adrenoceptor alpha 1D	Homo sapiens	122-129
20837014-3	2010	The phospholipase active site possesses a structurally conserved Cys-His-His catalytic triad as found in NlpC/P60 peptidases, indicating H-REV107 should adopt a similar catalytic mechanism towards phospholipid substrates to that of NlpC/P60 peptidases towards peptides.	Histidine	69-72	phospholipase A and acyltransferase 3	Homo sapiens	137-145
9256252-2	1997	Here we describe the high-level synthesis in Escherichia coli, and purification in the monomeric form, of a histidine-tagged full-length mature PrP (25-249) of bovine brain, termed His-PrP.	Histidine	108-117	PRP@	Bos taurus	144-147
20837014-3	2010	The phospholipase active site possesses a structurally conserved Cys-His-His catalytic triad as found in NlpC/P60 peptidases, indicating H-REV107 should adopt a similar catalytic mechanism towards phospholipid substrates to that of NlpC/P60 peptidases towards peptides.	Histidine	73-76	phospholipase A and acyltransferase 3	Homo sapiens	137-145
20682345-5	2010	The addition of GST, Trx or GB1 to the N-terminal His(6) tag significantly improved both the expression and solubility of target proteins as compared to His(6) tag alone.	Histidine	50-53	gamma-aminobutyric acid type B receptor subunit 1	Homo sapiens	28-31
20682345-5	2010	The addition of GST, Trx or GB1 to the N-terminal His(6) tag significantly improved both the expression and solubility of target proteins as compared to His(6) tag alone.	Histidine	153-156	gamma-aminobutyric acid type B receptor subunit 1	Homo sapiens	28-31
9256252-2	1997	Here we describe the high-level synthesis in Escherichia coli, and purification in the monomeric form, of a histidine-tagged full-length mature PrP (25-249) of bovine brain, termed His-PrP.	Histidine	108-117	PRP@	Bos taurus	185-188
9256252-2	1997	Here we describe the high-level synthesis in Escherichia coli, and purification in the monomeric form, of a histidine-tagged full-length mature PrP (25-249) of bovine brain, termed His-PrP.	Histidine	181-184	PRP@	Bos taurus	144-147
9256252-2	1997	Here we describe the high-level synthesis in Escherichia coli, and purification in the monomeric form, of a histidine-tagged full-length mature PrP (25-249) of bovine brain, termed His-PrP.	Histidine	181-184	PRP@	Bos taurus	185-188
9256252-3	1997	Based on biochemical and spectroscopic data, His-PrP displays characteristics expected for the PrP(C) isoform.	Histidine	45-48	PRP@	Bos taurus	49-52
20541267-4	2010	L-His reacts faster than the other N-donor nucleophiles in the reaction with [AuCl(2)(en)](+), but in the reaction with [AuCl(2)(SMC)] 5"-GMP is the best nucleophile.	Histidine	0-5	5'-nucleotidase, cytosolic II	Homo sapiens	138-141
9153214-8	1997	The conserved site altered by the suppressor mutations appears to be important; his4 HIP1-293 cells show an increased requirement for histidine compared with his4 HIP1 cells.	Histidine	134-143	histidine permease	Saccharomyces cerevisiae S288C	85-89
21558190-17	2010	The unique features of STC2, including 14 instead of 11 cysteines and a cluster of histidines in the C-terminal region, appear to be found exclusively in vertebrates.	Histidine	83-93	stanniocalcin 2	Homo sapiens	23-27
9180374-0	1997	A histidine variant of yeast iso-1-cytochrome c that strongly affects the energetics of the denatured state.	Histidine	2-11	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	29-34
20540760-4	2010	PRCP contains an alpha/beta hydrolase domain harboring the catalytic Asp-His-Ser triad and a novel helical structural domain that caps the active site.	Histidine	73-76	prolylcarboxypeptidase	Homo sapiens	0-4
9180374-1	1997	Iso-1-cytochrome c has been engineered to remove all histidine residues not involved in heme ligation in the native state to produce a variant designated TM.	Histidine	53-62	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	0-5
9173902-2	1997	In the present study we performed site-directed mutagenesis of the seven residues (Thr-38, Arg-47, Leu-54, Cys-87, Val-151, Arg-170 and Gln-172) of DD1 to the corresponding residues (Val, His, Val, Ser, Met, His and Leu respectively) of DD2.	Histidine	188-191	aldo-keto reductase family 1 member C1	Homo sapiens	148-151
20347923-1	2010	Among the emerging phospholipase A(2) (PLA(2)) superfamily, the secreted PLA(2) (sPLA(2)) family consists of low-molecular-mass, Ca(2+)-requiring extracellular enzymes with a His-Asp catalytic dyad.	Histidine	175-178	phospholipase A2, group IB, pancreas	Mus musculus	19-37
20347923-1	2010	Among the emerging phospholipase A(2) (PLA(2)) superfamily, the secreted PLA(2) (sPLA(2)) family consists of low-molecular-mass, Ca(2+)-requiring extracellular enzymes with a His-Asp catalytic dyad.	Histidine	175-178	phospholipase A2, group IB, pancreas	Mus musculus	39-45
20347923-1	2010	Among the emerging phospholipase A(2) (PLA(2)) superfamily, the secreted PLA(2) (sPLA(2)) family consists of low-molecular-mass, Ca(2+)-requiring extracellular enzymes with a His-Asp catalytic dyad.	Histidine	175-178	phospholipase A2, group IB, pancreas	Mus musculus	73-79
20347923-1	2010	Among the emerging phospholipase A(2) (PLA(2)) superfamily, the secreted PLA(2) (sPLA(2)) family consists of low-molecular-mass, Ca(2+)-requiring extracellular enzymes with a His-Asp catalytic dyad.	Histidine	175-178	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	81-88
9173902-2	1997	In the present study we performed site-directed mutagenesis of the seven residues (Thr-38, Arg-47, Leu-54, Cys-87, Val-151, Arg-170 and Gln-172) of DD1 to the corresponding residues (Val, His, Val, Ser, Met, His and Leu respectively) of DD2.	Histidine	208-211	aldo-keto reductase family 1 member C1	Homo sapiens	148-151
9147644-1	1997	We have generated polyclonal antibodies against the amino-terminal third of the Menkes protein (ATP7A; MNK) by immunizing rabbits with a histidine-tagged MNK fusion construct containing metal-binding domains 1-4.	Histidine	137-146	copper-transporting ATPase 1	Oryctolagus cuniculus	96-101
9073574-6	1997	As an example of such an approach, singlet oxygen has been implicated in the UVA radiation activation of HO-1 because the activation is enhanced by deuterium oxide (which enhances singlet oxygen lifetime) and suppressed by histidine (which scavenges the species).	Histidine	223-232	heme oxygenase 1	Homo sapiens	105-109
20811567-3	2010	The essential HIS3 gene from the histidine biosynthesis pathway was placed under the exclusive regulation of the galactose utilization system.	Histidine	33-42	imidazoleglycerol-phosphate dehydratase HIS3	Saccharomyces cerevisiae S288C	14-18
20404097-2	2010	We show that Snf1 promotes the formation of phosphorylated alpha subunit of eukaryotic translation initiation factor 2 (eIF2alpha-P), a regulator of general and gene-specific translation, by stimulating the function of eIF2alpha kinase Gcn2 during histidine starvation of glucose-grown cells.	Histidine	248-257	eukaryotic translation initiation factor 2A	Homo sapiens	120-129
9016654-3	1996	TIF1 beta, TIF1 alpha, PML and efp belong to a characteristic subgroup of RING finger proteins that contain one or two other Cys/His-rich clusters (B boxes) and a putative coiled-coil in addition to the classical C3HC4 RING finger motif (RBCC configuration).	Histidine	129-132	PML nuclear body scaffold	Homo sapiens	23-26
20404097-2	2010	We show that Snf1 promotes the formation of phosphorylated alpha subunit of eukaryotic translation initiation factor 2 (eIF2alpha-P), a regulator of general and gene-specific translation, by stimulating the function of eIF2alpha kinase Gcn2 during histidine starvation of glucose-grown cells.	Histidine	248-257	eukaryotic translation initiation factor 2A	Homo sapiens	219-228
8961924-1	1996	Rat spermatidal protein TP2 is a zinc metalloprotein with two atoms of zinc coordinated to cysteine and histidine residues and condenses alternating GC copolymer preferentially in a zinc dependent manner [Kundu, T. K., &amp; Rao, M. R. S. (1995) Biochemistry 34,5143-5150].	Histidine	104-113	transition protein 2	Homo sapiens	24-27
20684318-4	2010	The expression of the fusion protein HIS-annexin 5 was induced by isopropyl-beta-D-thiogalactoside (IPTG) under the control of the T7 promoter, and the products were purified by affinity chromatography.	Histidine	37-40	annexin A5	Rattus norvegicus	41-50
9010776-7	1996	We isolated a candidate cDNA for ABP-2, and the protein it encoded contained nine Zn fingers and regions rich in alanine, glutamine, serine/threonine, glycine, histidine, and asparagine.	Histidine	160-169	lava lamp	Drosophila melanogaster	33-38
20188155-1	2010	Thyrotropin-releasing hormone (TRH, pGlu-His-Pro-NH(2)) and the structurally related [Glu(2)]TRH (pGlu-Glu-Pro-NH(2)) are endogenous peptides with a plethora of actions in the central nervous system.	Histidine	41-44	thyrotropin releasing hormone	Mus musculus	0-29
8942679-0	1996	Active site structure in cytochrome c peroxidase and myoglobin mutants: effects of altered hydrogen bonding to the proximal histidine.	Histidine	124-133	myoglobin	Homo sapiens	53-62
19800635-7	2010	The interaction of SES x 5HIAA was a significant predictor of levels of CD11b and CD11c expression (p=.02, and p=.05, respectively); the mean CD11b difference between Hi and Lo SES subjects was significant (p=.003) only in those with Lo levels of 5HIAA, while SES differences in CD11b among those with Mid and Hi levels of 5HIAA did not vary statistically.	Histidine	167-169	integrin subunit alpha M	Homo sapiens	142-147
8917449-4	1996	This fusion protein has a deduced molecular mass of 65980 Da and is formed by fusion of the first 389 amino acids of diphtheria toxin to amino acids 2-184 of mature human LIF, using a linker of 34 amino acids that includes six consecutive histidine residues.	Histidine	239-248	LIF interleukin 6 family cytokine	Homo sapiens	171-174
19800635-7	2010	The interaction of SES x 5HIAA was a significant predictor of levels of CD11b and CD11c expression (p=.02, and p=.05, respectively); the mean CD11b difference between Hi and Lo SES subjects was significant (p=.003) only in those with Lo levels of 5HIAA, while SES differences in CD11b among those with Mid and Hi levels of 5HIAA did not vary statistically.	Histidine	167-169	integrin subunit alpha M	Homo sapiens	142-147
20023146-0	2010	The missing link in plant histidine biosynthesis: Arabidopsis myoinositol monophosphatase-like2 encodes a functional histidinol-phosphate phosphatase.	Histidine	26-35	inositol monophosphatase family protein	Arabidopsis thaliana	62-95
8798701-5	1996	Diethyl pyrocarbonate modification of His-4 and His-8 in the H75A/H84Q double mutant abolished neuritogenesis, binding to both receptors, and phosphorylation of p140(trkA) in PC12 cells.	Histidine	38-41	SRC kinase signaling inhibitor 1	Rattus norvegicus	161-165
20023146-8	2010	Our data demonstrate that IMPL2 is the HISN7 gene product, and suggest a lack of genetic redundancy at this metabolic step in Arabidopsis, which is characteristic of the His biosynthetic pathway.	Histidine	170-173	inositol monophosphatase family protein	Arabidopsis thaliana	26-31
8798701-5	1996	Diethyl pyrocarbonate modification of His-4 and His-8 in the H75A/H84Q double mutant abolished neuritogenesis, binding to both receptors, and phosphorylation of p140(trkA) in PC12 cells.	Histidine	48-51	SRC kinase signaling inhibitor 1	Rattus norvegicus	161-165
8816461-3	1996	For the yeast Saccharomyces cerevisiae, the Upf1 protein (Upf1p), which contains a cysteine- and histidine-rich region and nucleoside triphosphate hydrolysis and helicase motifs, was shown to be a trans-acting factor in this decay pathway.	Histidine	97-106	ATP-dependent RNA helicase NAM7	Saccharomyces cerevisiae S288C	44-48
20180985-4	2010	CNPase was expressed in E. coli with a TEV-cleavable His-tag.	Histidine	53-56	2',3'-cyclic nucleotide 3' phosphodiesterase	Mus musculus	0-6
8816461-3	1996	For the yeast Saccharomyces cerevisiae, the Upf1 protein (Upf1p), which contains a cysteine- and histidine-rich region and nucleoside triphosphate hydrolysis and helicase motifs, was shown to be a trans-acting factor in this decay pathway.	Histidine	97-106	ATP-dependent RNA helicase NAM7	Saccharomyces cerevisiae S288C	58-63
8808628-0	1996	A cluster of cytoplasmic histidine residues specifies pH dependence of the AE2 plasma membrane anion exchanger.	Histidine	25-34	solute carrier family 4 member 2	Homo sapiens	75-78
8808628-3	1996	The data in this paper identify a histidine-rich sequence within the cytoplasmic domain of the nonerythroid anion exchanger, AE2, that serves as an intracellular pH "sensor" that modulates anion exchange activity within the physiological range of cytoplasmic pH.	Histidine	34-43	solute carrier family 4 member 2	Homo sapiens	125-128
20118557-7	2010	AutoDocking results showed that timolol binds at the entrance of the active site cavity in a region where the proton shuttle residue, His 64, of HCA I or II, is placed.	Histidine	134-137	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	145-156
8760919-1	1996	The Rhodobacter sphaeroides 2.4.1 hisI gene, which encodes a phosphoribosyl-AMP-cyclohydrolase that catalyses the third step in the histidine biosynthetic pathway, has been isolated from a genomic library of this phototrophic bacterium by complementation of an Escherichia coli hisI mutant.	Histidine	132-141	phosphoribosyl-AMP cyclohydrolase	Rhodobacter sphaeroides 2.4.1	34-38
8760919-1	1996	The Rhodobacter sphaeroides 2.4.1 hisI gene, which encodes a phosphoribosyl-AMP-cyclohydrolase that catalyses the third step in the histidine biosynthetic pathway, has been isolated from a genomic library of this phototrophic bacterium by complementation of an Escherichia coli hisI mutant.	Histidine	132-141	phosphoribosyl-AMP cyclohydrolase	Rhodobacter sphaeroides 2.4.1	278-282
8844860-9	1996	Thus, the effects on TCR binding of the His 135 residue could actually be mediated, wholly or in part, by the alpha 1 helix.	Histidine	40-43	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	21-24
19946898-8	2009	Furthermore, using a combined approach based on SDS-PAGE, MALDI-TOF and HPLC-ESI-IT mass spectrometry, we were able to identify one main MMP-9 cleavage site that is localized between the amino acids His-715 and Leu-716 of beta-DG, and we analysed the proteolytic fragments of beta-DG(654-750) produced by MMP-9 enzymatic activity.	Histidine	199-202	matrix metallopeptidase 9	Homo sapiens	137-142
8663386-4	1996	Lysines are the only residues to be engaged in the dimerization with human retinoid X receptor alpha (hRXRalpha) in the absence of DNA, whereas histidines are selectively involved in the homodimerization of hRARalpha in the presence of a RARE.	Histidine	144-154	retinoic acid receptor alpha	Homo sapiens	207-216
19720102-1	2009	We found that beta-lactotensin (His-Ile-Arg-Leu), which has been isolated as an ileum-contracting peptide from chymotrypsin digest of bovine beta-lactoglobulin, dose-dependently suppresses food intake after intracerebroventricular (i.c.v.)	Histidine	32-35	beta-lactoglobulin	Bos taurus	141-159
8757974-8	1996	VLP collected from sucrose density gradient fractions contained protein which reacted with nickel chelated to nitrilotriacetic acid, a histidine-specific reagent.	Histidine	135-144	VHL like	Homo sapiens	0-3
19567267-2	2009	The encoded recombinant hOCTN1 resulted in a 6-His tagged fusion protein with a 34 or 21 amino acid extra N-terminal sequence in the pET-28a(+)-hOCTN1 or in the pH6EX3-hOCTN1 constructs, respectively.	Histidine	47-50	solute carrier family 22 member 4	Homo sapiens	24-30
19912621-1	2009	BACKGROUND: Protein kinase C interacting protein (PKCI/HINT1) is a small protein belonging to the histidine triad (HIT) family proteins.	Histidine	98-107	protein kinase C, iota	Mus musculus	50-54
19912621-1	2009	BACKGROUND: Protein kinase C interacting protein (PKCI/HINT1) is a small protein belonging to the histidine triad (HIT) family proteins.	Histidine	98-107	histidine triad nucleotide binding protein 1	Mus musculus	55-60
8785300-1	1996	Actin labeled at Gln-41 with dansyl ethylenediamine (DED) via transglutaminase reaction was used for monitoring the interaction of myosin subfragment 1 (S1) with the His-40-Gly-42 site in the 38-52 loop on F-actin.	Histidine	166-169	myosin heavy chain 14	Homo sapiens	131-137
19754350-8	2009	Arg-His-Arg haplotype of XRCC1 significantly enhanced the risk for hepatitis by 2.8-folds (p = 0.001), but not for HCC (odds ratio = 1.5; p = 0.28).	Histidine	4-7	X-ray repair cross complementing 1	Homo sapiens	25-30
8935176-4	1996	The data show that it is possible for a beta turn to exist in the ring portion of this molecule which contains the melanocortin conserved sequence - His-Phe-Arg-Trp-, even though the lowest energy conformers lack a beta turn.	Histidine	149-152	amyloid beta (A4) precursor protein	Mus musculus	38-44
19843177-7	2009	In addition, the structure of a new class of lipid with a histidine head group, found in all of the strains of flies, but lower in Maroon Like, was elucidated.	Histidine	58-67	maroon-like	Drosophila melanogaster	131-142
8538770-5	1996	The histidine at position 1,106(aspartic acid in C4A) first attacks the thioester to form an acyl-imidazole intermediate.	Histidine	4-13	complement C4A (Rodgers blood group)	Homo sapiens	49-52
19735445-0	2009	Cyclo(His-Pro) up-regulates heme oxygenase 1 via activation of Nrf2-ARE signalling.	Histidine	6-9	heme oxygenase 1	Rattus norvegicus	28-44
8547652-3	1996	Sequencing of the whole coding region of the c-kit showed that the point mutation found in HMC-1, P-815, and RBL-2H3 cells was absent in FMA3 cells and that the c-kit cDNA of FMA3 cells carried an in-frame deletion of 21 base pairs (bp) encoding Thr-Gln-Leu-Pro-Tyr-Asp-His at codons 573 to 579 at the juxtamembrane domain.	Histidine	270-273	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	161-166
20641508-4	2004	GRP and BN share an identical C-terminal region (-Trp-Ala-Val-Gly-His-Leu-Met-NH2) which is necessary for receptor binding and signal transduction (56).	Histidine	66-69	gastrin releasing peptide	Homo sapiens	0-3
8618839-5	1995	AAT1-mediated histidine transport is sensitive to protonophores and occurs against a concentration gradient, indicating that AAT1 may function as a proton symporter.	Histidine	14-23	amino acid transporter 1	Arabidopsis thaliana	0-4
19826048-8	2009	The histidine allele at codon 48 of ADH1B gene was associated with a significantly decreased risk of ESCC in the joint data set (primary and validation set) under a recessive model (odds ratio, 0.41; 95% confidence interval, 0.29-0.76; P = 4 x 10(-4)).	Histidine	4-13	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	36-41
8586268-5	1995	TEM-29 derived from TEM-1, with an amino acid substitution, his-164.	Histidine	60-63	beta-lactamase	Klebsiella pneumoniae	20-25
19757795-2	2009	In order to model the syn disposition of histidine residues in carboxylate-bridged non-heme diiron enzymes, we prepared a new dinucleating ligand, H(2)BPG(2)DEV, that provides this geometric feature.	Histidine	41-50	synemin	Homo sapiens	22-25
20641903-4	2004	GRP and BN share an identical C-terminal region (-Trp-Ala-Val-Gly-His-Leu-Met-NH2), which is necessary for receptor binding and signal transduction (5, 6).	Histidine	66-69	gastrin releasing peptide	Homo sapiens	0-3
20641937-2	2004	Bombesin (BN) is an amphibian neuropeptide consisting of 14 amino acids (pGlu-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2) (2, 3), first isolated from frog skin in 1970 (4).	Histidine	118-121	gastrin releasing peptide	Homo sapiens	0-8
20641937-4	2004	GRP and BN share an identical C-terminal region (-Trp-Ala-Val-Gly-His-Leu-Met-NH2), which is necessary for receptor binding and signal transduction (5, 6).	Histidine	66-69	gastrin releasing peptide	Homo sapiens	0-3
8590759-5	1995	However, simultaneous expression of exogenous p53 and ras or p53 and mos produced opposite effects, i.e., a dramatic decrease in the AD activity and complete (p53wt, His-273) or partial (His-175, Trp-248) restoration of the HPRT activity.	Histidine	166-169	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	46-49
19685901-0	2009	Transition path sampling study of the conformational fluctuation of His-64 in human carbonic anhydrase II.	Histidine	68-71	carbonic anhydrase 2	Homo sapiens	84-105
19685901-1	2009	We report here a transition path sampling study of the conformational fluctuation of His-64 that is known to be important in the enzymatic catalysis of human carbonic anhydrase II.	Histidine	85-88	carbonic anhydrase 2	Homo sapiens	158-179
8590759-5	1995	However, simultaneous expression of exogenous p53 and ras or p53 and mos produced opposite effects, i.e., a dramatic decrease in the AD activity and complete (p53wt, His-273) or partial (His-175, Trp-248) restoration of the HPRT activity.	Histidine	166-169	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	61-64
19735146-6	2009	We show that the peptide charge, and more precisely the protonation state of histidines 13 and/or 14, is important for the interaction with lipids.	Histidine	77-87	olfactory receptor family 10 subfamily K member 2	Homo sapiens	95-100
8590759-5	1995	However, simultaneous expression of exogenous p53 and ras or p53 and mos produced opposite effects, i.e., a dramatic decrease in the AD activity and complete (p53wt, His-273) or partial (His-175, Trp-248) restoration of the HPRT activity.	Histidine	166-169	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	61-64
8590759-5	1995	However, simultaneous expression of exogenous p53 and ras or p53 and mos produced opposite effects, i.e., a dramatic decrease in the AD activity and complete (p53wt, His-273) or partial (His-175, Trp-248) restoration of the HPRT activity.	Histidine	187-190	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	46-49
8590759-5	1995	However, simultaneous expression of exogenous p53 and ras or p53 and mos produced opposite effects, i.e., a dramatic decrease in the AD activity and complete (p53wt, His-273) or partial (His-175, Trp-248) restoration of the HPRT activity.	Histidine	187-190	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	61-64
8590759-5	1995	However, simultaneous expression of exogenous p53 and ras or p53 and mos produced opposite effects, i.e., a dramatic decrease in the AD activity and complete (p53wt, His-273) or partial (His-175, Trp-248) restoration of the HPRT activity.	Histidine	187-190	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	61-64
19487247-0	2009	Influence of N-terminal domain histidine and proline residues on the substrate selectivities of human UDP-glucuronosyltransferase 1A1, 1A6, 1A9, 2B7, and 2B10.	Histidine	31-40	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	102-133
8750797-6	1995	Moreover, the ameliorating effect of histidine was antagonized by a histamine H1-receptor antagonist, pyrilamine, but not by zolantidine, a histamine H2-receptor antagonist.	Histidine	37-46	histamine receptor H1	Mus musculus	68-89
19487247-1	2009	An N-terminal domain histidine [corresponding to position 39 of UDP-glucuronosyltransferase (UGT) 1A1] is conserved in all UGT1A and UGT2B subfamily proteins except UGT1A4 (Pro-40) and UGT2B10 (Leu-34).	Histidine	21-30	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	64-101
19487247-5	2009	The conserved N-terminal domain histidine of UGT1A1, UGT1A6, UGT1A9, and UGT2B7 was mutated to proline and leucine 34 of UGT2B10 was substituted with histidine, and the capacity of the wild-type and mutant proteins to glucuronidate 4MU, 1NP, LTG, TFP, and naproxen was characterized.	Histidine	32-41	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	45-51
19487247-5	2009	The conserved N-terminal domain histidine of UGT1A1, UGT1A6, UGT1A9, and UGT2B7 was mutated to proline and leucine 34 of UGT2B10 was substituted with histidine, and the capacity of the wild-type and mutant proteins to glucuronidate 4MU, 1NP, LTG, TFP, and naproxen was characterized.	Histidine	32-41	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	73-79
7673234-6	1995	An additional increase in agonist activity was observed when the beta-bulge was co-expressed with a second substitution (His-54 --&gt; Pro) in IL-1ra K145D.	Histidine	121-124	interleukin 1 receptor antagonist	Homo sapiens	143-149
19487247-5	2009	The conserved N-terminal domain histidine of UGT1A1, UGT1A6, UGT1A9, and UGT2B7 was mutated to proline and leucine 34 of UGT2B10 was substituted with histidine, and the capacity of the wild-type and mutant proteins to glucuronidate 4MU, 1NP, LTG, TFP, and naproxen was characterized.	Histidine	150-159	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	45-51
19487247-5	2009	The conserved N-terminal domain histidine of UGT1A1, UGT1A6, UGT1A9, and UGT2B7 was mutated to proline and leucine 34 of UGT2B10 was substituted with histidine, and the capacity of the wild-type and mutant proteins to glucuronidate 4MU, 1NP, LTG, TFP, and naproxen was characterized.	Histidine	150-159	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	73-79
7664874-0	1995	Effect of enzymatic desialylation of human serum amyloid P component on surface exposure of laser photo CIDNP (chemically induced dynamic nuclear polarization)--reactive histidine, tryptophan and tyrosine residues.	Histidine	170-179	amyloid P component, serum	Homo sapiens	43-68
19809679-5	2009	Coordination of Asp 1 to Zn drives the complex towards the expulsion of one of initially bonded His side-chains.	Histidine	96-99	beta-secretase 2	Homo sapiens	16-21
7664874-6	1995	Six tryptophan/histidine signals and one tyrosine signal are present in the aromatic part of the CIDNP difference spectrum of SAP.	Histidine	15-24	amyloid P component, serum	Homo sapiens	126-129
7623840-2	1995	Previous studies have shown that in response to histidine starvation, GCN2 phosphorylates eukaryotic initiation factor 2 (eIF-2), to induce the translational expression of GCN4, a transcriptional activator of genes subject to the general amino acid control.	Histidine	48-57	eukaryotic translation initiation factor 2 subunit beta	Homo sapiens	90-120
19505476-5	2009	FH became more elongated at pH 9.4, showing the involvement of histidine residue(s) in its folded-back structure.	Histidine	63-72	complement factor H	Homo sapiens	0-2
7623840-2	1995	Previous studies have shown that in response to histidine starvation, GCN2 phosphorylates eukaryotic initiation factor 2 (eIF-2), to induce the translational expression of GCN4, a transcriptional activator of genes subject to the general amino acid control.	Histidine	48-57	eukaryotic translation initiation factor 2 subunit beta	Homo sapiens	122-127
7623840-6	1995	We show that GCN2 phosphorylation of eIF-2, and the resulting general amino acid control pathway, is stimulated in response to starvation for each of several different amino acids, in addition to histidine limitation.	Histidine	196-205	eukaryotic translation initiation factor 2 subunit beta	Homo sapiens	37-42
19332149-2	2009	Mutations in the phylogenetically conserved histidine 127 of the SDHC subunit have been shown to abrogate heme binding in yeast and bacteria without impairing complex II assembly or enzymatic activities.	Histidine	44-53	succinate dehydrogenase complex subunit C	Homo sapiens	65-69
7632723-2	1995	Our results indicate that P13 binds to the sixth coordination position of the Fe(III) of microperoxidase (Keq = 4.8 x 10(4) M-1 at pH 7.0 and 25 degrees C) via the imidazole of His-12, forming a stable complex.	Histidine	177-180	H3 histone pseudogene 6	Homo sapiens	26-29
19473029-5	2009	Substitution of His in MTII also provided functional selectivity for the hMC3R or the hMC4R.	Histidine	16-19	melanocortin 4 receptor	Homo sapiens	86-91
19397338-8	2009	An N-terminal His-tagged version of human Mia40, a resident oxidoreductase of the IMS and a putative physiological reductant of lfALR, was subcloned and expressed in Escherichia coli BL21 DE3 cells.	Histidine	14-17	coiled-coil-helix-coiled-coil-helix domain containing 4	Homo sapiens	42-47
7615633-3	1995	In this study, oligonucleotide-directed mutagenesis is used to alter the COOH-terminal portion of Sec8 with a 6-histidine tag, a 9E10 c-myc epitope, or both, to allow the isolation of the Sec8/15 complex from yeast lysates either by immobilized metal affinity chromatography or by immunoprecipitation.	Histidine	112-121	exocyst subunit SEC8	Saccharomyces cerevisiae S288C	98-102
7769716-9	1995	Results of these experiments verified that HCMV CD3 serine (Ser-132) and CD2 histidine (His-63) are essential for proteolytic activity and identified a glutamic acid (Glu-122) within CD3 that is also essential for proteolytic activity and may be conserved among all herpesvirus assemblin homologs.	Histidine	77-86	CD2 molecule	Homo sapiens	73-76
19191736-7	2009	Those residues responsible for anchoring the hexose moieties of the dTDP-sugars to the protein include Glu 141, Asn 159, and Asp 160 from one subunit and His 134 from another subunit.	Histidine	154-157	TAR DNA-binding protein-43 homolog	Drosophila melanogaster	68-72
7769716-9	1995	Results of these experiments verified that HCMV CD3 serine (Ser-132) and CD2 histidine (His-63) are essential for proteolytic activity and identified a glutamic acid (Glu-122) within CD3 that is also essential for proteolytic activity and may be conserved among all herpesvirus assemblin homologs.	Histidine	88-91	CD2 molecule	Homo sapiens	73-76
7769716-10	1995	We suggest that CD3 Glu-122, CD3 Ser-132, and CD2 His-63 constitute the active-site triad of this serine proteinase.	Histidine	50-53	CD2 molecule	Homo sapiens	46-49
7744755-0	1995	Histidine tagging both allows convenient single-step purification of bovine rhodopsin and exerts ionic strength-dependent effects on its photochemistry.	Histidine	0-9	rhodopsin	Bos taurus	76-85
7748897-2	1995	In the mollusc myoglobin, in which His-E7 is replaced by Val, the guanidino group of Arg-E10 serves as an alternative hydrogen-bond donor to the bound ligand.	Histidine	35-38	myoglobin	Homo sapiens	15-24
18926804-11	2009	Furthermore, RDH-E2 expressed in Sf9 insect cells as a fusion to the C-terminal His(6)-tag and purified using Ni(2+)-affinity chromatography recognizes all-trans-retinol and all-trans-retinaldehyde as substrates and exhibits a strong preference for NAD(+)/NADH as cofactors.	Histidine	80-83	short chain dehydrogenase/reductase family 16C member 5	Homo sapiens	13-19
19129463-6	2009	OATP1C1 is lacking a highly conserved histidine in the third transmembrane domain, which was shown by site-directed mutagenesis to be critically involved in the pH dependency of OATPs/Oatps.	Histidine	38-47	solute carrier organic anion transporter family member 1C1	Homo sapiens	0-7
7733663-5	1995	Western blot analysis, using antibody generated against purified 6 x His-tagged Trx1p, showed that both mutant forms of Trx1p were present at the same levels as the wild-type protein.	Histidine	69-72	thioredoxin TRX1	Saccharomyces cerevisiae S288C	120-125
19002498-5	2009	It was overexpressed as approximately 50 kDa His-tag fusion protein, and ATP hydrolysis assay of recombinant enzyme showed that either ATP or dATP was required for the unwinding activity, indicating BmL3-helicase as an ATP/dATP-dependent RNA helicase.	Histidine	45-48	DEAD-box helicase 19A	Homo sapiens	238-250
7629021-7	1995	In chicken beta-enolase, on the other hand, the corresponding tyrosine residue was found to be replaced with a histidine residue, in accordance with the previous observation that chicken beta-enolase was not phosphorylated in vivo or in vitro.	Histidine	111-120	enolase 3 (beta, muscle)	Gallus gallus	11-23
19178182-7	2009	Those amino acid side chains involved in binding the dTDP-sugar into the active site include Tyr 183, His 309, and Tyr 310 from subunit 1 and Lys 219 from subunit 2.	Histidine	102-105	TAR DNA-binding protein-43 homolog	Drosophila melanogaster	53-57
7629021-7	1995	In chicken beta-enolase, on the other hand, the corresponding tyrosine residue was found to be replaced with a histidine residue, in accordance with the previous observation that chicken beta-enolase was not phosphorylated in vivo or in vitro.	Histidine	111-120	enolase 3 (beta, muscle)	Gallus gallus	187-199
18983266-4	2009	We show using purified His(6)-tagged Rab11 protein and beta2AR intracellular domains fused to GST (glutathione transferase) that Rab11 interacts directly with the C-terminal tail of beta2AR, but not with the other intracellular domains of the receptor.	Histidine	23-26	adrenoceptor beta 2	Homo sapiens	182-189
7539160-9	1995	Lys in position 144 and His in position 151 are apparently critical for RG1 binding.	Histidine	24-27	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	72-75
7865131-9	1995	The presence of potential processing multibasic sites suggests that small peptides could be generated (particularly a hexapeptide: Arg-Gln-His-Asn-Leu-Arg), as in the case of the SMR1-VA1 protein of R. norvegicus.	Histidine	139-142	submaxillary gland androgen regulated protein 3B	Rattus norvegicus	179-183
19061898-3	2009	The inhibitor stabilizes the N-terminal domain of NS3p and the substrate-binding site, and correctly aligns catalytic His-Asp residues.	Histidine	118-121	KRAS proto-oncogene, GTPase	Homo sapiens	50-54
20641947-0	2004	(99m)Tc Nitrido(diphosphine)-Cys-beta-Ala-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2 The amphibian bombesin (BBN or BN, a peptide of 14 amino acids) is an analog of human gastrin-releasing peptide (GRP, a peptide of 27 amino acids) that binds to GRP receptors (GRPR) with high affinity and specificity (1, 2).	Histidine	62-65	gastrin releasing peptide	Homo sapiens	92-100
7723584-6	1995	Moreover, the ameliorating effect of histidine was antagonized by a histamine H1 receptor antagonist, pyrilamine.	Histidine	37-46	histamine receptor H1	Mus musculus	68-89
7838710-6	1994	The results of the experiments using bacterially expressed MSSP-2, and its deletion mutants, as histidine fusion proteins suggested that the binding specificity of MSSP-2 to double- and single-stranded DNA is the same as that of MSSP-1, and that the RNP consensus sequences are required for the DNA binding of the protein.	Histidine	96-105	RNA binding motif single stranded interacting protein 1 pseudogene 1	Homo sapiens	229-235
19272175-3	2009	METHODS: To identify the critical amino acid residues of human EndoG, we replaced the conserved histidine, asparagine, and arginine residues with alanine.	Histidine	96-105	endonuclease G	Homo sapiens	63-68
19272175-5	2009	RESULTS: Diethyl pyrocarbonate modification assay revealed that histidine residues were involved in EndoG activity.	Histidine	64-73	endonuclease G	Homo sapiens	100-105
19272175-6	2009	His-141, Asn-163, and Asn-172 in the H-N-H motif of EndoG were critical for catalysis and substrate specificity.	Histidine	0-3	endonuclease G	Homo sapiens	52-57
7875743-11	1994	All monoclonal IgG3 proteins derived from Oriental subjects with or without histidine at position 435 bound to HSV Fc gamma-binding protein.	Histidine	76-85	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	15-19
18852012-15	2008	The first NAT crystallographic structure from Salmonella typhimurium identified the mechanism of acetyl transfer via a catalytic triad of Cys, His and Asp residues each essential for activity in all NATs.	Histidine	143-146	bromodomain containing 2	Homo sapiens	10-13
18952607-5	2008	A direct interaction was indicated by in vitro pull-down assay, in which S-His-RASA3 preferentially bound guanosine 5"-O-(gamma-thio)triphosphate-activated Galphai3 and Galphai2 compared with guanosine 5"-O-(beta-thio)diphosphate-inactivated proteins.	Histidine	75-78	RAS p21 protein activator 3	Rattus norvegicus	79-84
18848840-7	2008	Compared with individuals carrying genotypes of hOGG1 326Cys/Cys and hMYH 324His/His at the same time, there was a 0.33-fold (OR(adj), 0.33; 95% CI: 0.15-0.72; P&lt;0.05) decreased risk of CBP for those with genotypes of hOGG1 326Ser/Cys+Ser/Ser and hMYH 324His/Gln+Gln/Gln.	Histidine	77-80	mutY DNA glycosylase	Homo sapiens	69-73
7957084-5	1994	This newly identified histidine in ArcB and BarA was demonstrated to play a crucial role in the observed multicopy suppression.	Histidine	22-31	hypothetical protein	Escherichia coli	35-39
18848840-7	2008	Compared with individuals carrying genotypes of hOGG1 326Cys/Cys and hMYH 324His/His at the same time, there was a 0.33-fold (OR(adj), 0.33; 95% CI: 0.15-0.72; P&lt;0.05) decreased risk of CBP for those with genotypes of hOGG1 326Ser/Cys+Ser/Ser and hMYH 324His/Gln+Gln/Gln.	Histidine	77-80	mutY DNA glycosylase	Homo sapiens	250-254
7957084-6	1994	Furthermore, it was demonstrated in vivo and in vitro for ArcB that the C-terminal domain containing the histidine can function as an alternative phosphodonor (or transmitter).	Histidine	105-114	hypothetical protein	Escherichia coli	58-62
20641678-1	2004	Both GRP and BBN share an amidated C-terminus sequence homology of 7 amino acids, -Trp-Ala-Val-Gly-His-Leu-Met-NH2.	Histidine	99-102	gastrin releasing peptide	Homo sapiens	5-8
18829452-7	2008	Here we report on the interactions of RhoA, Rac1, and Cdc42 with mDia1 and an mDia1 mutant (mDia(N)-Thr-Ser-His (TSH)), which based on structural information should mimic mDia2 and -3.	Histidine	108-111	Rac family small GTPase 1	Homo sapiens	44-48
7533846-13	1994	Second, the amino acid compositions differ significantly, e.g., GRASP is not histidine- but rather glycine-rich.	Histidine	77-86	trafficking regulator and scaffold protein tamalin	Homo sapiens	64-69
7929296-1	1994	The human cytomegalovirus UL80 protease was expressed in Escherichia coli and purified by metal-chelate chromatography using a histidine tag engineered at the amino terminus.	Histidine	127-136	capsid maturation protease	Human betaherpesvirus 5	26-30
7925571-7	1994	The pH dependence of IgG1 or Fc fragment binding to FcRn is consistent with the localization of the FcRn interaction site to a region of the Fc that encompasses two histidine residues (His 310 and His 433).	Histidine	165-174	Fc fragment of IgG receptor and transporter	Mus musculus	52-56
18629612-3	2008	Sod2 was expressed in Saccharomyces cerevisiae with a C-terminal histidine tag under control of the GAL1 promoter.	Histidine	65-74	superoxide dismutase SOD2	Saccharomyces cerevisiae S288C	0-4
20641607-12	2004	(177)Lu-AMBA consists of two components: a peptide of eight amino acids that is composed of the seven common amino acids in the C-terminus of BBN/GRP (Trp-Ala-Val-Gly-His-Leu-Met) and a complex of (177)Lu-DOTA attached to the N-terminus of the peptide via a glycyl-4-aminobezoic acid linker.	Histidine	167-170	gastrin releasing peptide	Homo sapiens	142-149
7925571-7	1994	The pH dependence of IgG1 or Fc fragment binding to FcRn is consistent with the localization of the FcRn interaction site to a region of the Fc that encompasses two histidine residues (His 310 and His 433).	Histidine	165-174	Fc fragment of IgG receptor and transporter	Mus musculus	100-104
7925571-7	1994	The pH dependence of IgG1 or Fc fragment binding to FcRn is consistent with the localization of the FcRn interaction site to a region of the Fc that encompasses two histidine residues (His 310 and His 433).	Histidine	185-188	Fc fragment of IgG receptor and transporter	Mus musculus	52-56
18767815-3	2008	In Ngb, the imidazole of a histidine residue (His-64) in the distal position, above the heme plane, provides the sixth coordination bond.	Histidine	27-36	neuroglobin	Homo sapiens	3-6
18767815-3	2008	In Ngb, the imidazole of a histidine residue (His-64) in the distal position, above the heme plane, provides the sixth coordination bond.	Histidine	46-49	neuroglobin	Homo sapiens	3-6
7925571-7	1994	The pH dependence of IgG1 or Fc fragment binding to FcRn is consistent with the localization of the FcRn interaction site to a region of the Fc that encompasses two histidine residues (His 310 and His 433).	Histidine	185-188	Fc fragment of IgG receptor and transporter	Mus musculus	100-104
18767815-11	2008	Together, the data support the argument that wild-type Ngb is protected from attack by H 2O 2 by the coordinated distal His.	Histidine	120-123	neuroglobin	Homo sapiens	55-58
7925571-7	1994	The pH dependence of IgG1 or Fc fragment binding to FcRn is consistent with the localization of the FcRn interaction site to a region of the Fc that encompasses two histidine residues (His 310 and His 433).	Histidine	197-200	Fc fragment of IgG receptor and transporter	Mus musculus	52-56
7925571-7	1994	The pH dependence of IgG1 or Fc fragment binding to FcRn is consistent with the localization of the FcRn interaction site to a region of the Fc that encompasses two histidine residues (His 310 and His 433).	Histidine	197-200	Fc fragment of IgG receptor and transporter	Mus musculus	100-104
7883764-5	1994	We independently isolated a full-length cDNA encoding human CENP-C and expressed it as the polypeptide tagged with histidine oligomer in Escherichia coli.	Histidine	115-124	centromere protein C	Homo sapiens	60-66
18656261-4	2008	(1)H NMR and EPR studies demonstrate that the predominant oxidation state of Fe in ETHE1 is Fe(II), and NMR studies confirm that two histidines are bound to Fe(II).	Histidine	133-143	glyoxalase II 3	Arabidopsis thaliana	83-88
7913462-4	1994	rITF2 is a rat homolog of human ITF2 (or E2-2), and CDP2 is a member of a new family of homeoproteins defined by histidine as the 9th residue of the recognition helix and by unique 64 amino acid repeats related to those of the Drosophila cut gene.	Histidine	113-122	transcription factor 4	Rattus norvegicus	0-5
18621979-10	2008	In vitro filter-binding assays indicating that histidine-tagged ACBP6 binds phosphatidylcholine, but not phosphatidic acid or lysophosphatidylcholine, further imply a role for ACBP6 in phospholipid metabolism in Arabidopsis, including the possibility of ACBP6 in the cytosolic trafficking of phosphatidylcholine.	Histidine	47-56	acyl-CoA-binding protein 6	Arabidopsis thaliana	64-69
18621979-10	2008	In vitro filter-binding assays indicating that histidine-tagged ACBP6 binds phosphatidylcholine, but not phosphatidic acid or lysophosphatidylcholine, further imply a role for ACBP6 in phospholipid metabolism in Arabidopsis, including the possibility of ACBP6 in the cytosolic trafficking of phosphatidylcholine.	Histidine	47-56	acyl-CoA-binding protein 6	Arabidopsis thaliana	176-181
18621979-10	2008	In vitro filter-binding assays indicating that histidine-tagged ACBP6 binds phosphatidylcholine, but not phosphatidic acid or lysophosphatidylcholine, further imply a role for ACBP6 in phospholipid metabolism in Arabidopsis, including the possibility of ACBP6 in the cytosolic trafficking of phosphatidylcholine.	Histidine	47-56	acyl-CoA-binding protein 6	Arabidopsis thaliana	176-181
7515969-0	1994	The Cys-His motif of Ty3 NC can be contributed by Gag3 or Gag3-Pol3 polyproteins.	Histidine	8-11	Mdv1p	Saccharomyces cerevisiae S288C	50-54
18515357-3	2008	Kinetic analysis revealed that substitution of His-110e, which anchors the loop in occluding position, results in 3-fold increased chagasin affinity (Ki for H110A cathepsin B, 0.35 nm) due to an improved association rate (kon, 5 x 10(5) m(-1)s(-1)).	Histidine	47-50	cathepsin B	Homo sapiens	163-174
7515969-0	1994	The Cys-His motif of Ty3 NC can be contributed by Gag3 or Gag3-Pol3 polyproteins.	Histidine	8-11	Mdv1p	Saccharomyces cerevisiae S288C	58-62
7920705-8	1994	A modified SUC1-His6 cDNA encoding a histidine tag at the SUC1 C-terminus was also expressed in S. cerevisiae.	Histidine	37-46	sucrose-proton symporter 1	Arabidopsis thaliana	11-15
18597497-7	2008	Recombinant CBR underwent irreversible inhibition during QM exposure, and mass spectrometry was utilized to identify alkylation sites at Cys 51, Lys 17, Lys 189, Lys 201, His 28, and His 204.	Histidine	183-186	carbonyl reductase 1	Mus musculus	12-15
7920705-8	1994	A modified SUC1-His6 cDNA encoding a histidine tag at the SUC1 C-terminus was also expressed in S. cerevisiae.	Histidine	37-46	sucrose-proton symporter 1	Arabidopsis thaliana	58-62
8208612-5	1994	HEPR does not contain the carboxyl-terminus leucine zipper motif identified in REPR but contains consensus phosphorylation sites as well as the conserved histidine and both cysteine residues identified as a Zn2+ binding motif in other cytidine deaminases.	Histidine	154-163	apolipoprotein B mRNA editing enzyme catalytic subunit 1	Homo sapiens	0-4
18276838-4	2008	Expressed and purified from bacteria using affinity chromatography, the AKR1A1 protein with a single histidine (6x-His) tag exhibited the greatest activity using two test substrates: p-nitrobenzaldehyde (5.09 +/- 0.16 micromol/min/mg of purified protein) and DL-glyceraldehyde (1.24 +/- 0.17 micromol/min/mg).	Histidine	101-110	aldo-keto reductase family 1 member A1	Homo sapiens	72-78
18276838-6	2008	The 6x-His-tagged AKR1A1 wild type and allelic variants, E55D and N52S, were subsequently examined for metabolic activity using DAUN and DOX.	Histidine	7-10	aldo-keto reductase family 1 member A1	Homo sapiens	18-24
18263814-1	2008	PURPOSE: A Tyr-to-His (Y402H) sequence variant in the factor H (FH) and factor H-like protein (FHL-1) gene is strongly associated with an increased susceptibility for age-related macular degeneration (AMD).	Histidine	18-21	complement factor H	Homo sapiens	54-62
18263814-1	2008	PURPOSE: A Tyr-to-His (Y402H) sequence variant in the factor H (FH) and factor H-like protein (FHL-1) gene is strongly associated with an increased susceptibility for age-related macular degeneration (AMD).	Histidine	18-21	complement factor H	Homo sapiens	72-80
8175783-1	1994	Protein synthesis elongation factor 2 (EF-2) from eukaryotes contains an unusual modified histidine residue, termed diphthamide.	Histidine	90-99	elongation factor 2	Saccharomyces cerevisiae S288C	18-37
8175783-1	1994	Protein synthesis elongation factor 2 (EF-2) from eukaryotes contains an unusual modified histidine residue, termed diphthamide.	Histidine	90-99	elongation factor 2	Saccharomyces cerevisiae S288C	39-43
8175783-3	1994	We expressed mutant genes of EF-2 with substitutions of 19 other amino acids for His-699, which is modified to diphthamide, in yeast cells and found that they can be classified into three groups.	Histidine	81-84	elongation factor 2	Saccharomyces cerevisiae S288C	29-33
8175783-4	1994	In the first group (Group 1), replacement of His-699 by the basic amino acid Arg or Lys showed not only loss of EF-2 activity but also inhibitory effects on the growth of cells co-expressing wild-type EF-2.	Histidine	45-48	elongation factor 2	Saccharomyces cerevisiae S288C	112-116
18194442-1	2008	Two histidines are known to be essential for zinc potentiation of rat P2X2 receptors, but the chemistry of zinc coordination would suggest that other residues also participate in this zinc-binding site.	Histidine	4-14	purinergic receptor P2X 2	Rattus norvegicus	70-74
8175783-4	1994	In the first group (Group 1), replacement of His-699 by the basic amino acid Arg or Lys showed not only loss of EF-2 activity but also inhibitory effects on the growth of cells co-expressing wild-type EF-2.	Histidine	45-48	elongation factor 2	Saccharomyces cerevisiae S288C	201-205
18370410-2	2008	Here, we address the role of the conserved active site Ser167 residue in human IDO (S167A and S167H variants), which is replaced with a histidine in other mammalian and bacterial TDO enzymes.	Histidine	136-145	tryptophan 2,3-dioxygenase	Homo sapiens	179-182
8087556-11	1994	CONCLUSION: The structure of Candida antarctica lipase B shows that the enzyme has a Ser-His-Asp catalytic triad in its active site.	Histidine	89-92	PAN0_003d1715	Moesziomyces antarcticus	48-54
18178100-6	2008	To determine if the presence of the C-terminal his-tag altered ACBP interactions with other proteins, direct binding to hepatocyte nuclear factor-4alpha (HNF-4alpha), a nuclear receptor regulating transcription of genes involved in lipid metabolism, was examined.	Histidine	47-50	hepatic nuclear factor 4, alpha	Mus musculus	154-164
8300604-6	1994	In contrast to the human neurokinin-1 receptor, both histidine 197 and histidine 265 in the rat neurokinin-1 receptor appear to interact with both CP-96,345 and RP67580.	Histidine	71-80	tachykinin receptor 1	Rattus norvegicus	96-117
18194661-7	2008	Site-directed mutagenesis of any of the four conserved histidine residues (His 50, 86, 120 and 159) to alanine resulted in much diminished levels of heme in the purified Dcytb, while mutation of the non-conserved histidine 33 had no effect on the heme content.	Histidine	55-64	cytochrome b reductase 1	Homo sapiens	170-175
8300628-6	1994	Both represent the ultimate residues of a 50-amino acid consensus motif with six conserved cysteines and two conserved histidines present in the cysteine-rich regions of all PKC isoforms.	Histidine	119-129	protein kinase C gamma	Homo sapiens	174-177
18194661-7	2008	Site-directed mutagenesis of any of the four conserved histidine residues (His 50, 86, 120 and 159) to alanine resulted in much diminished levels of heme in the purified Dcytb, while mutation of the non-conserved histidine 33 had no effect on the heme content.	Histidine	75-78	cytochrome b reductase 1	Homo sapiens	170-175
8282694-20	1994	Four histidine-rich polypeptide regions in ORF1 and CopA strongly resembled the copper-binding motifs of small blue copper proteins and multicopper oxidases, such as fungal laccases, plant ascorbate oxidase, and human ceruloplasmin.	Histidine	5-14	ceruloplasmin	Homo sapiens	218-231
18008383-1	2008	Modification of His-47 and removal of the N-terminal octapeptide caused a different effect on the structure of Naja naja atra (Taiwan cobra) phospholipase A2 (PLA2).	Histidine	16-19	phospholipase A2 group IIA	Homo sapiens	159-163
8245015-2	1993	Nm23 was previously demonstrated to exhibit nucleoside diphosphate kinase (NDPK) activity, which transfers a phosphate among nucleoside tri- and diphosphates via an Nm23-phospho-histidine intermediate.	Histidine	178-187	NME/NM23 family member 7	Mus musculus	44-73
18008383-3	2008	Moreover, the spatial positions of Trp residues in His-modified PLA2 were not properly rearranged toward lipid-water interface in the presence of Ca2+.	Histidine	51-54	phospholipase A2 group IIA	Homo sapiens	64-68
18008383-5	2008	Although a precipitous drop in the enzymatic activity was observed with modified PLA2, His-modified PLA2 and N-terminally truncated PLA2 retained cytotoxicity on inducing necrotic death of human neuroblastoma SK-N-SH cells.	Histidine	87-90	phospholipase A2 group IIA	Homo sapiens	100-104
18008383-5	2008	Although a precipitous drop in the enzymatic activity was observed with modified PLA2, His-modified PLA2 and N-terminally truncated PLA2 retained cytotoxicity on inducing necrotic death of human neuroblastoma SK-N-SH cells.	Histidine	87-90	phospholipase A2 group IIA	Homo sapiens	100-104
8245015-2	1993	Nm23 was previously demonstrated to exhibit nucleoside diphosphate kinase (NDPK) activity, which transfers a phosphate among nucleoside tri- and diphosphates via an Nm23-phospho-histidine intermediate.	Histidine	178-187	NME/NM23 family member 7	Mus musculus	75-79
8106194-1	1993	Tritium-labeled growth hormone releasing peptide His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 was synthesized by tritium-halogen exchange on the precursor His-5,7-Br2-D-Trp-Ala-Trp-D-Phe-Lys-NH2.	Histidine	49-52	ghrelin and obestatin prepropeptide	Homo sapiens	16-48
8106194-1	1993	Tritium-labeled growth hormone releasing peptide His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 was synthesized by tritium-halogen exchange on the precursor His-5,7-Br2-D-Trp-Ala-Trp-D-Phe-Lys-NH2.	Histidine	142-145	ghrelin and obestatin prepropeptide	Homo sapiens	16-48
18094146-6	2008	Replacement of histidine 26 (H26) in the NH(2) terminus with alanine eliminated the requirement of protons for channel activity and increased sensitivity to proton-induced inhibition, resulting in maximal channel activity at alkaline pH(i) and smaller whole cell currents at resting pH(i) compared with wild-type Kir7.1.	Histidine	15-24	potassium inwardly rectifying channel subfamily J member 13	Homo sapiens	313-319
8218161-8	1993	A novel feature of the In-EOTUBE/Fab" complex is coordination of the indium by N epsilon of one histidine from the heavy chain"s third CDR (distance = 2.4 A).	Histidine	96-105	FA complementation group B	Homo sapiens	33-36
20641773-2	2004	Both GRP and BN share an amidated C-terminus sequence homology of 7 amino acids, -Trp-Ala-Val-Gly-His-Leu-Met-NH2.	Histidine	98-101	gastrin releasing peptide	Homo sapiens	5-8
8373184-0	1993	Role of the highly conserved histidine residues in rat liver mitochondrial aldehyde dehydrogenase as studied by site-directed mutagenesis.	Histidine	29-38	aldehyde dehydrogenase 2 family member	Rattus norvegicus	61-97
18574322-1	2008	We recently showed that arginine transport via cationic amino acid transporter 1 (CAT1), which transports arginine, lysine, ornithine, and histidine, is essential for erythropoiesis.	Histidine	139-148	solute carrier family 7 member 1	Homo sapiens	47-80
18574322-1	2008	We recently showed that arginine transport via cationic amino acid transporter 1 (CAT1), which transports arginine, lysine, ornithine, and histidine, is essential for erythropoiesis.	Histidine	139-148	solute carrier family 7 member 1	Homo sapiens	82-86
20641931-0	2004	(99m)Tc-pGlu-Gln-Trp-Ala-Val-Gly-His-Phe-Met-NH2 Bombesin (BBN or BN)-like peptide is an analog of human gastrin-releasing peptide (GRP) that binds to GRP receptors (GRP-R) (1).	Histidine	33-36	gastrin releasing peptide	Homo sapiens	49-57
20641931-0	2004	(99m)Tc-pGlu-Gln-Trp-Ala-Val-Gly-His-Phe-Met-NH2 Bombesin (BBN or BN)-like peptide is an analog of human gastrin-releasing peptide (GRP) that binds to GRP receptors (GRP-R) (1).	Histidine	33-36	gastrin releasing peptide	Homo sapiens	105-130
8373184-1	1993	One histidine residue (H235) is conserved in all known aldehyde dehydrogenases (ALDH), from Escherichia coli to human, except for those from P. oleovorans and rat hepatoma.	Histidine	4-13	aldehyde dehydrogenase 2 family member	Rattus norvegicus	80-84
8373184-3	1993	Using site-directed mutagenesis, the four conserved histidine residues of the six histidines in rat liver mitochondrial ALDH were converted to alanines.	Histidine	52-61	aldehyde dehydrogenase 2 family member	Rattus norvegicus	120-124
8373184-3	1993	Using site-directed mutagenesis, the four conserved histidine residues of the six histidines in rat liver mitochondrial ALDH were converted to alanines.	Histidine	82-92	aldehyde dehydrogenase 2 family member	Rattus norvegicus	120-124
20641931-0	2004	(99m)Tc-pGlu-Gln-Trp-Ala-Val-Gly-His-Phe-Met-NH2 Bombesin (BBN or BN)-like peptide is an analog of human gastrin-releasing peptide (GRP) that binds to GRP receptors (GRP-R) (1).	Histidine	33-36	gastrin releasing peptide	Homo sapiens	132-135
8373184-13	1993	Instead, both H29 and H235 may be of structural importance and the presence of a histidine residue at position 235 may be required for the newly synthesized peptide to fold and/or assemble into the native conformation of ALDH.	Histidine	81-90	aldehyde dehydrogenase 2 family member	Rattus norvegicus	221-225
8100523-7	1993	When human serum was incubated with GIP or GLP-1(7-36)amide the same fragments as with the purified dipeptidyl-peptidase IV, namely the des-Xaa-Ala peptides and Tyr-Ala in the case of GIP or His-Ala in the case of GLP-1(7-36)amide, were identified as the main degradation products of these peptide hormones.	Histidine	191-194	dipeptidyl peptidase 4	Homo sapiens	100-123
8332461-8	1993	EF-Gmt differs from its cytoplasmic homolog, EF-2, in that it contains an aspartic acid residue at amino acid position 621 which corresponds to the EF-2 histidine residue at position 715.	Histidine	153-162	G elongation factor, mitochondrial 1	Rattus norvegicus	0-6
17962323-4	2007	In the human protein, sequence substitution of tyrosine by histidine at this critical position generated a mutant that displays almost identical proton sensitivity compared with mouse TRESK.	Histidine	59-68	potassium channel, subfamily K, member 18	Mus musculus	184-189
8332461-9	1993	Since this histidine residue, following posttranslational modification into diphthamide, appears to be the sole cellular target of diphtheria toxin and Pseudomonas aeruginosa endotoxin A, we conclude that EF-Gmt will not be inactivated by these toxins.	Histidine	11-20	G elongation factor, mitochondrial 1	Rattus norvegicus	205-211
18039930-19	2007	Site-directed mutagenesis of these His residues results in the loss of RIDalpha-RILP interaction and RIDalpha activity in cells.	Histidine	35-38	reactive intermediate imine deaminase A homolog	Homo sapiens	71-79
18039930-19	2007	Site-directed mutagenesis of these His residues results in the loss of RIDalpha-RILP interaction and RIDalpha activity in cells.	Histidine	35-38	reactive intermediate imine deaminase A homolog	Homo sapiens	101-109
8454063-4	1993	Histidine phosphorylation of P36 was activated in vitro by recombinant Ras protein and GTP; both decreased Michaelis constant (Km) for ATP from 1.25 to 0.25 microM.	Histidine	0-9	annexin A2	Rattus norvegicus	29-32
20641605-3	2004	Both GRP and BN share an amidated C-terminus sequence homology of seven amino acids, -Trp-Ala-Val-Gly-His-Leu-Met-NH2.	Histidine	102-105	gastrin releasing peptide	Homo sapiens	5-8
8447323-9	1993	In the SRY PCR product of gonadal DNA, the wild-type and two point mutations were present in the patient"s sequence, simulating a heterozygous state of a Y-chromosomal gene: one of the mutations was silent, while the other encoded for a nonconservative amino acid substitution from leucine to histidine.	Histidine	293-302	sex determining region Y	Homo sapiens	7-10
17929833-10	2007	The X-ray structure of the human cytosolic MetAP1 showed three Co2+ ions at the active site, with the third Co2+ coordinated by the conserved residue His 212 [Addlagatta, A., Hu, X., Liu, J. O., and Matthews, B. W. (2005) Biochemistry 44, 14741-14749].	Histidine	150-153	methionyl aminopeptidase 1	Homo sapiens	43-49
7682215-4	1993	The association constant of 15-carboxymethylated histidine lysozyme (15CM lysozyme) with the immobilized Fab fragment was smaller by one-seventh than that of 15-carboxamidated histidine lysozyme, though the side chains introduced were almost identical in size.	Histidine	49-58	FA complementation group B	Homo sapiens	105-108
17888579-5	2007	This inhibition did not pose any problem in kinetic analysis, for within the relevant Mn2+ concentration range the His-tagged human PEPCK behaved almost identically to the tag-free enzyme.	Histidine	115-118	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	132-137
7682215-4	1993	The association constant of 15-carboxymethylated histidine lysozyme (15CM lysozyme) with the immobilized Fab fragment was smaller by one-seventh than that of 15-carboxamidated histidine lysozyme, though the side chains introduced were almost identical in size.	Histidine	176-185	FA complementation group B	Homo sapiens	105-108
19517008-3	2007	Several green fluorescent protein (GFP)-fused and histidine (His)-tagged chimeras of ALMT1 were prepared based on a computer-predicted secondary structure and transiently expressed in cultured mammalian cells.	Histidine	50-59	aluminum-activated malate transporter 1	Triticum aestivum	85-90
19517008-3	2007	Several green fluorescent protein (GFP)-fused and histidine (His)-tagged chimeras of ALMT1 were prepared based on a computer-predicted secondary structure and transiently expressed in cultured mammalian cells.	Histidine	61-64	aluminum-activated malate transporter 1	Triticum aestivum	85-90
8433973-1	1993	Dihydrofolate reductase mutants with amino acid replacements in the active center (Thr35--&gt;Asp mutant, Arg57--&gt;His mutant and the mutant with triple replacement Thr35--&gt;Asp, Asn37--&gt;Ser, Arg57--&gt;His) were obtained by site-directed mutagenesis.	Histidine	210-213	dihydrofolate reductase	Homo sapiens	0-23
1400571-3	1992	Deletion of the carboxyl-terminal Leu-Leu-His-Val residues of the 163 amino acid cytoplasmic tail of the bovine Man-6-P/IGF-II receptor partially impaired this function, resulting in the diversion of a portion of the receptor-ligand complexes to the cell surface, where they were endocytosed.	Histidine	42-45	insulin like growth factor 2 receptor	Homo sapiens	120-135
17924654-6	2007	Here, using ThrRS as an example, rapid single-turnover kinetics, mutagenesis, and solvent isotope analysis show that a strictly conserved histidine (between ThrRS and AlaRS) extracts a proton in the chemical step of the editing reaction.	Histidine	138-147	threonyl-tRNA synthetase 3	Homo sapiens	12-17
17924654-6	2007	Here, using ThrRS as an example, rapid single-turnover kinetics, mutagenesis, and solvent isotope analysis show that a strictly conserved histidine (between ThrRS and AlaRS) extracts a proton in the chemical step of the editing reaction.	Histidine	138-147	threonyl-tRNA synthetase 3	Homo sapiens	157-162
17924654-6	2007	Here, using ThrRS as an example, rapid single-turnover kinetics, mutagenesis, and solvent isotope analysis show that a strictly conserved histidine (between ThrRS and AlaRS) extracts a proton in the chemical step of the editing reaction.	Histidine	138-147	alanyl-tRNA synthetase 1	Homo sapiens	167-172
1376926-9	1992	(iv) Both basal and 4F2hc cRNA-stimulated sodium-independent uptake of L-arginine show two additional characteristics of the system y+ transport activity: inhibition of L-arginine uptake by L-homoserine only in the presence of sodium and an increase in the inhibition exerted by L-histidine as the extracellular pH decreased.	Histidine	279-290	solute carrier family 3 member 2	Homo sapiens	20-25
1353910-1	1992	The histidine residue at position 715 of elongation factor 2 (EF-2) is posttranslationally modified in a series of enzymatic reactions to 2-[3-carboxyamido-3-(trimethylammonio)-propyl]histidine, which has been given the trivial name diphthamide.	Histidine	4-13	eukaryotic translation elongation factor 2	Homo sapiens	41-60
17850513-10	2007	Therefore, our model explains the mechanistic necessity for conservation of not only active site histidines but also adjacent amino acids in tyrosinase.	Histidine	97-107	tyrosinase	Homo sapiens	141-151
1381368-8	1992	This suggests that the histidine at residue 34 in the light-chain CDR1 is largely responsible for the dextran binding.	Histidine	23-32	cerebellar degeneration related protein 1	Homo sapiens	66-70
17496029-1	2007	In the cytochrome c-551 family, the heme 17-propionate caboxylate group is always hydrogen bonded to an invariant Trp-56 and conserved residues (His and Arg mainly, Lys occasionally) at position 47.	Histidine	145-148	cytochrome c3 family protein	Pseudomonas stutzeri	7-19
1581520-6	1992	Since for goat alpha-lactalbumin the Cu2+ binding to His-68 is much less important than for bovine alpha-lactalbumin, we observe a somewhat different conformational behaviour for goat alpha-lactalbumin.	Histidine	53-56	alpha-lactalbumin	Capra hircus	15-32
17572636-6	2007	Protein modeling predicts that substitution with histidine, and only histidine, creates a pH-sensitive switch within the activation domain of the receptor that leads to ligand-independent activation of ACVR1 in fibrodysplasia ossificans progressiva.	Histidine	49-58	activin A receptor type 1	Homo sapiens	202-207
17572636-6	2007	Protein modeling predicts that substitution with histidine, and only histidine, creates a pH-sensitive switch within the activation domain of the receptor that leads to ligand-independent activation of ACVR1 in fibrodysplasia ossificans progressiva.	Histidine	69-78	activin A receptor type 1	Homo sapiens	202-207
1567557-4	1992	By making site-directed mutations in the wild-type IgG3 or IgG4 human gamma constant genes, we showed that His-435 is an essential residue in RF binding to IgG for most WMac RFs.	Histidine	107-110	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	51-55
17710231-4	2007	Mapping of H193R mutation onto the crystal structure of myrosinase, a plant homolog of KL, revealed that this histidine residue was at the base of the deep catalytic cleft and mutation of this histidine to arginine should destabilize the putative glycosidase domain (KL1) of KL, thereby attenuating production of membrane-bound and secreted KL.	Histidine	110-119	KIT ligand	Homo sapiens	267-270
17710231-4	2007	Mapping of H193R mutation onto the crystal structure of myrosinase, a plant homolog of KL, revealed that this histidine residue was at the base of the deep catalytic cleft and mutation of this histidine to arginine should destabilize the putative glycosidase domain (KL1) of KL, thereby attenuating production of membrane-bound and secreted KL.	Histidine	193-202	KIT ligand	Homo sapiens	267-270
1371672-0	1992	In the GluR1 glutamate receptor subunit a glutamine to histidine point mutation suppresses inward rectification but not calcium permeability.	Histidine	55-64	glutamate ionotropic receptor AMPA type subunit 1	Homo sapiens	7-12
17768240-3	2007	spdB2 of the conjugative pSVH1 plasmid of Streptomyces venezuelae was heterologously expressed in Escherichia coli and Streptomyces lividans, with a C-terminal His-tag-encoding sequence.	Histidine	160-163	SpdB2 protein	Streptomyces venezuelae	0-5
1616501-4	1992	The pKEA = 6.5 suggests that histidine is in active site of DAO.	Histidine	29-38	D-amino acid oxidase	Homo sapiens	60-63
20641271-3	2004	Both GRP and BN share an amidated C-terminus sequence homology of 7 amino acids, -Trp-Ala-Val-Gly-His-Leu-Met-NH2.	Histidine	98-101	gastrin releasing peptide	Homo sapiens	5-8
1551684-1	1992	Two amino acids, tyrosine at position 96 and histidine at position 99 in the variable heavy chain (VH) CDR3 region of a mouse/human chimeric anti-TAG72 antibody cB72.3-1-3 were substituted with phenylalanine and asparagine respectively by site-directed mutagenesis technique.	Histidine	45-54	cerebellar degeneration-related 3	Mus musculus	103-107
17583729-3	2007	We have investigated this conformational factor in the denatured state of iso-1-cytchrome c using a five alanine insert in front of a unique histidine in the N-terminal region of the protein.	Histidine	141-150	eukaryotic translation initiation factor 1	Homo sapiens	74-79
1311747-8	1992	The Km and Vmax values of the detergent-solubilized ACE for Hip-His-Leu were 32 x 10(-5) mol/l and 11.75 nmol/min respectively, and for AI they were 6.5 x 10(-5) mol/l and 0.97 nmol/min.	Histidine	64-67	angiotensin I converting enzyme	Gallus gallus	52-55
17636946-4	2007	The deleterious effects on inhibitor potency by methylation of the anilino-triazole nitrogens, as well as the X-ray crystal structure of triazole 102 bound in the active site of MetAP2, confirm the key interactions between the triazole nitrogens, the active site cobalt atoms, and the His-231 side-chain.	Histidine	285-288	methionyl aminopeptidase 2	Homo sapiens	178-184
17438030-3	2007	To investigate the LcrV-TLR2 interaction in vitro, His-tagged recombinant LcrV (rLcrV) from Yersinia pestis was cloned and expressed in Escherichia coli and purified through Ni-nitrilotriacetic acid column chromatography.	Histidine	51-54	Yop secretion and targeting control protein	Yersinia pestis	19-23
17438030-3	2007	To investigate the LcrV-TLR2 interaction in vitro, His-tagged recombinant LcrV (rLcrV) from Yersinia pestis was cloned and expressed in Escherichia coli and purified through Ni-nitrilotriacetic acid column chromatography.	Histidine	51-54	Yop secretion and targeting control protein	Yersinia pestis	74-78
1558877-2	1992	The C-terminal and the N-terminal amino acid sequences of the low-molecular-mass protein A were -Asn-Ala-Phe and Ala-Gln-His-Asp-Glu-Ala-Gln-, respectively.	Histidine	121-124	G protein-coupled receptor 162	Gallus gallus	81-90
17391984-7	2007	An amino acid substitution from Glu 57 to Gly located at one of the four conserved His-Glu (HE) pairs, the potential metal coordination sites, resulted in severe reduction of deoxyhypusine hydroxylase activity.	Histidine	83-86	deoxyhypusine hydroxylase	Bos taurus	175-200
1346133-7	1992	Furthermore, we identify a single histidine residue in the alpha 1 variant, replaced by an arginine in alpha 6, as a major determinant for high affinity binding of BZ agonists.	Histidine	34-43	adrenoceptor alpha 1D	Homo sapiens	59-66
17360715-7	2007	The side chains of His/Tyr(402) have similar, solvent-exposed orientations far from interfaces with CCP6 and -8.	Histidine	19-22	AGBL carboxypeptidase 4	Homo sapiens	100-104
1346133-9	1992	Hence, this histidine present in the alpha 1, alpha 2, alpha 3, and alpha 5 subunits appears to be a key residue for the action of clinically used BZ ligands.	Histidine	12-21	adrenoceptor alpha 1D	Homo sapiens	37-44
17444659-1	2007	The variant of Aequorea green fluorescent protein (GFP) known as blue fluorescent protein (BFP) was originally engineered by substituting histidine for tyrosine in the chromophore precursor sequence.	Histidine	138-147	ring finger protein 112	Homo sapiens	65-89
17444659-1	2007	The variant of Aequorea green fluorescent protein (GFP) known as blue fluorescent protein (BFP) was originally engineered by substituting histidine for tyrosine in the chromophore precursor sequence.	Histidine	138-147	ring finger protein 112	Homo sapiens	91-94
17475008-8	2007	Molecular docking experiments identified key residues in donor and acceptor recognition and provided insight into the catalytic mechanism of UGT glucuronidation, suggesting the human UGT1A1 residue histidine 39 (H39) as a general base and the residue aspartic acid 151 (D151) as an important electron-transfer helper.	Histidine	198-207	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	183-189
1739745-9	1992	10% of calf apoA-I was shown to contain a propeptide, with the sequence Arg-His-Phe-Trp-Gln-Gln.	Histidine	76-79	APOAI	Bos taurus	12-18
1370358-3	1992	For these RFs, His-435 is a critical residue for binding and replacing it with arginine, the residue present in IgG3, destroys or reduces RF binding.	Histidine	15-18	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	112-116
1762145-5	1991	The hypothesis that the copper atom in stellacyanin is co-ordinated by the side-chain functional groups of histidine 46, cysteine 87, histidine 92 and glutamine 97 leads to a model that enables the spectroscopic properties, redox potential and electron-transfer kinetics of the protein to be rationalized.	Histidine	107-116	blue copper protein	Cucumis sativus	39-51
18690027-4	2007	We demonstrate here that the mouse RIM1 arginine-to-histidine substitution (R655H), which corresponds to the human CORD7 mutation, modifies RIM1 function in regulating VDCC currents elicited by the P/Q-type Ca(v)2.1 and L-type Ca(v)1.4 channels.	Histidine	52-61	regulating synaptic membrane exocytosis 1	Homo sapiens	115-120
18690027-4	2007	We demonstrate here that the mouse RIM1 arginine-to-histidine substitution (R655H), which corresponds to the human CORD7 mutation, modifies RIM1 function in regulating VDCC currents elicited by the P/Q-type Ca(v)2.1 and L-type Ca(v)1.4 channels.	Histidine	52-61	regulating synaptic membrane exocytosis 1	Homo sapiens	140-144
1762145-5	1991	The hypothesis that the copper atom in stellacyanin is co-ordinated by the side-chain functional groups of histidine 46, cysteine 87, histidine 92 and glutamine 97 leads to a model that enables the spectroscopic properties, redox potential and electron-transfer kinetics of the protein to be rationalized.	Histidine	134-143	blue copper protein	Cucumis sativus	39-51
17267065-4	2007	Here, we synthesized a novel pH-sensitive histidine-modified galactosylated cholesterol derivative (Gal-His-C4-Chol), for a more efficient gene delivery to hepatocytes.	Histidine	42-51	galanin and GMAP prepropeptide	Homo sapiens	100-103
1956045-0	1991	Substrate analogue renin inhibitors containing replacements of histidine in P2 or isosteres of the amide bond between P3 and P2 sites.	Histidine	63-72	renin	Macaca fascicularis	19-24
1807008-7	1991	The present study indicates that histidine at the 7th position of GLP-1 is important in eliciting biological action and that only truncated GLP-1 (7-36), (7-37), and (7-20) showed an insulinotropic action as strong as glucagon in dogs.	Histidine	33-42	glucagon	Canis lupus familiaris	66-71
17398321-3	2007	Recently, a complement factor H (CFH) polymorphism, which is characterized by a tyrosine (Y)-to-histidine (H) exchange at position 402 of the CFH gene, has been suggested as a major risk factor for AMD in a North American population.	Histidine	96-105	complement factor H	Homo sapiens	12-31
17398321-3	2007	Recently, a complement factor H (CFH) polymorphism, which is characterized by a tyrosine (Y)-to-histidine (H) exchange at position 402 of the CFH gene, has been suggested as a major risk factor for AMD in a North American population.	Histidine	96-105	complement factor H	Homo sapiens	33-36
17398321-3	2007	Recently, a complement factor H (CFH) polymorphism, which is characterized by a tyrosine (Y)-to-histidine (H) exchange at position 402 of the CFH gene, has been suggested as a major risk factor for AMD in a North American population.	Histidine	96-105	complement factor H	Homo sapiens	142-145
1684671-7	1991	The effects of histidine, as well as histamine, were blocked by mepyramine, a histamine H1-receptor antagonist, and by ranitidine, an H2-antagonist.	Histidine	15-24	histamine receptor H1	Homo sapiens	78-99
17419840-8	2007	The growth and uptake studies identified glutamate, histidine and neutral amino acids, including phenylalanine, as physiological substrates for AAP1, whereas aspartate, lysine and arginine are not.	Histidine	52-61	amino acid permease 1	Arabidopsis thaliana	144-148
1718967-5	1991	This showed that the nitrate reductase heme domain is structurally very similar to cytochrome b5 and it also confirmed that the residue involved in E56 mutation is one of the two heme-binding histidines.	Histidine	192-202	cytochrome b5 type A	Homo sapiens	83-96
17290983-6	2007	The effective nodal plane of low-spin NP1, NP4, and NP2 complexes is in all cases of imidazole and histamine complexes quite similar to the average of the His-59 or -57 and the exogenous ligand angles seen in the X-ray crystal structures.	Histidine	155-158	neuropilin 2	Homo sapiens	52-55
1930211-0	1991	Alteration of human myoglobin proximal histidine to cysteine or tyrosine by site-directed mutagenesis: characterization and their catalytic activities.	Histidine	39-48	myoglobin	Homo sapiens	20-29
17202136-0	2007	A histidine-rich cluster mediates the ubiquitination and degradation of the human zinc transporter, hZIP4, and protects against zinc cytotoxicity.	Histidine	2-11	solute carrier family 39 member 4	Homo sapiens	100-105
1681027-4	1991	By sequencing the protein coding region of the PrP gene in Cheviot sheep selected for differing Sip genotypes, we have found four PrP protein variants which differ at three positions: amino acid 112 (Ala/Val), amino acid 130 (Arg/His) and amino acid 147 (Arg/Gln).	Histidine	230-233	major prion protein	Ovis aries	47-50
17316554-4	2007	(2004a) Biochemistry 43:1369-1375] have shown that the replacement of either methionine with histidine in the PSI of the unicellular green alga Chlamydomonas reinhardtii resulted in accumulation of A(0)(-) (in 300-ps time scale), suggesting that both the PsaA and PsaB branches are active.	Histidine	93-102	photosystem I P700 chlorophyll a apoprotein A2	Chlamydomonas reinhardtii	264-268
1681027-4	1991	By sequencing the protein coding region of the PrP gene in Cheviot sheep selected for differing Sip genotypes, we have found four PrP protein variants which differ at three positions: amino acid 112 (Ala/Val), amino acid 130 (Arg/His) and amino acid 147 (Arg/Gln).	Histidine	230-233	major prion protein	Ovis aries	130-133
1656519-4	1991	Allelic variants were isolated at the second locus: a novel clone encoding apoSAA2 alpha was distinguished from SAA2 beta (previously known as SAAg9, Ref.1) by a His/Arg polymorphism at residue 71.SAA1 and SAA2 found in the high density lipoprotein fraction of acute-phase plasma were approximately 90% homologous at the nucleotide level.	Histidine	162-165	serum amyloid A2	Homo sapiens	78-82
17251580-3	2007	Mutational analysis of cysteine and histidine residues within the conserved N-terminal zinc-binding domain in NSP1 of bovine rotavirus strain B641 abolished IRF3 degradation in transfected cells.	Histidine	36-45	interferon regulatory factor 3	Bos taurus	157-161
1930184-0	1991	Current inactivation involves a histidine residue in the pore of the rat lymphocyte potassium channel RGK5.	Histidine	32-41	potassium voltage-gated channel subfamily A member 3	Rattus norvegicus	102-106
17088264-9	2007	The inhibition profile of a tyrosine kinase, Abl (a histidine-tagged recombinant mouse Abl kinase), was determined using the substrate Abltide-GST (a fusion protein consisting of a specific substrate peptide for Abl and glutathione S-transferase) and the approved drug Glivec (an ATP competitor).	Histidine	52-61	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	45-48
17088264-9	2007	The inhibition profile of a tyrosine kinase, Abl (a histidine-tagged recombinant mouse Abl kinase), was determined using the substrate Abltide-GST (a fusion protein consisting of a specific substrate peptide for Abl and glutathione S-transferase) and the approved drug Glivec (an ATP competitor).	Histidine	52-61	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	87-90
17088264-9	2007	The inhibition profile of a tyrosine kinase, Abl (a histidine-tagged recombinant mouse Abl kinase), was determined using the substrate Abltide-GST (a fusion protein consisting of a specific substrate peptide for Abl and glutathione S-transferase) and the approved drug Glivec (an ATP competitor).	Histidine	52-61	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	87-90
1930189-6	1991	TP2 has revealed the presence of two potential zinc finger motifs involving cysteine and histidine residues.	Histidine	89-98	transition protein 2	Homo sapiens	0-3
1655536-1	1991	Horse heart cytochrome c with either histidine or cysteine replacing the endogenous axial methionine ligand at position 80 has been characterized with magnetic circular dichroism (MCD) spectroscopy in the UV-visible region.	Histidine	37-46	cytochrome c, somatic	Equus caballus	12-24
17469229-3	2007	The protein was expressed in Escherichia coli with or without an N-terminal His-tag and had functional DASPO activity that was highly specific for D-aspartate and N-methyl-D-aspartate.	Histidine	76-79	D-aspartate oxidase	Mus musculus	103-108
17469229-4	2007	To investigate the roles of the Arg-216 and Arg-237 residues of the mouse DASPO (mDASPO), we generated clones with several single amino acid substitutions of these residues in an N-terminally His-tagged mDASPO.	Histidine	192-195	D-aspartate oxidase	Mus musculus	74-79
2040614-4	1991	In fact, hPL contains virtually the same receptor-binding determinants and zinc ligands (His-18, His-21, and Glu-174) that hGH uses for coordinating zinc in the hGH.hPRLbp complex.	Histidine	89-92	galectin 1	Homo sapiens	9-12
17066390-1	2007	In the present study the importance of the active site histidine residue (His) for the activity of epoxide- or aziridine-based cysteine protease inhibitors is examined theoretically.	Histidine	55-64	cathepsin B	Homo sapiens	127-144
17066390-1	2007	In the present study the importance of the active site histidine residue (His) for the activity of epoxide- or aziridine-based cysteine protease inhibitors is examined theoretically.	Histidine	74-77	cathepsin B	Homo sapiens	127-144
2040614-4	1991	In fact, hPL contains virtually the same receptor-binding determinants and zinc ligands (His-18, His-21, and Glu-174) that hGH uses for coordinating zinc in the hGH.hPRLbp complex.	Histidine	97-100	galectin 1	Homo sapiens	9-12
1847138-2	1991	The chemical modification of histidine and arginine residues results in a loss of binding of the Mr 46,000 mannose 6-phosphate receptor (MPR 46) to a phosphomannan affinity matrix (Stein, M., Meyer, J. E., Hasilik, A., and von Figura, K. (1987) Biol.	Histidine	29-38	mannose-6-phosphate receptor, cation dependent	Homo sapiens	137-143
17453047-4	2007	We rewired the genome by recruiting an essential gene, HIS3, from the histidine biosynthesis pathway to a foreign regulatory system, the GAL network responsible for galactose utilization.	Histidine	70-79	imidazoleglycerol-phosphate dehydratase HIS3	Saccharomyces cerevisiae S288C	55-59
1847138-6	1991	The 5 histidine and 8 arginine residues within the luminal domain of MPR 46, which contains the ligand binding site, were exchanged by site-directed mutagenesis.	Histidine	6-15	mannose-6-phosphate receptor, cation dependent	Homo sapiens	69-75
1847138-10	1991	We conclude from these results that His-131 and Arg-137 are essential for binding of ligands by MPR 46.	Histidine	36-39	mannose-6-phosphate receptor, cation dependent	Homo sapiens	96-102
17027633-2	2006	We modeled one mutation in human cTnI C-terminus, arginine192--&gt;histidine (R192H) by cardiac specific expression of the mutated protein (cTnI(193His) in mouse sequence) in transgenic mice.	Histidine	67-76	troponin I3, cardiac type	Homo sapiens	33-37
17027633-2	2006	We modeled one mutation in human cTnI C-terminus, arginine192--&gt;histidine (R192H) by cardiac specific expression of the mutated protein (cTnI(193His) in mouse sequence) in transgenic mice.	Histidine	67-76	troponin I3, cardiac type	Homo sapiens	140-144
2079039-2	1990	A crude product of GHRP, a hexapeptide with the sequence His-D-Trp-Ala-Trp-D-Phe-Lys-NH2, synthesized by the solid phase methodology, was desalted and analyzed by CZE.	Histidine	57-60	ghrelin and obestatin prepropeptide	Homo sapiens	19-23
17081490-9	2006	While the successful incorporation of the His-tag into our constructs was confirmed by Epo binding to Ni(2+)- nitrilotriacetic acid resin and by microcapillary reverse-phase high-performance liquid chromatography nano-electrospray tandem mass spectrometery amino acid sequencing, the levels of immunodetection of His-tagged protein varied markedly depending on the particular anti-His-tag antibody used.	Histidine	42-45	erythropoietin	Cricetulus griseus	87-90
2170418-6	1990	These regions are located between amino acids Asn-230 and Ile-285 on the IR and between His-223 and Met-274 on the IGFIR.	Histidine	88-91	insulin-like growth factor 1 receptor	Cricetulus griseus	115-120
17078101-5	2006	We found that among GSTT1(+) individuals the DEB-induced SCE level was significantly lower when the EPHX 139 codon was His/Arg rather than His/His.	Histidine	119-122	glutathione S-transferase theta 1	Homo sapiens	20-25
17078101-5	2006	We found that among GSTT1(+) individuals the DEB-induced SCE level was significantly lower when the EPHX 139 codon was His/Arg rather than His/His.	Histidine	139-142	glutathione S-transferase theta 1	Homo sapiens	20-25
17078101-5	2006	We found that among GSTT1(+) individuals the DEB-induced SCE level was significantly lower when the EPHX 139 codon was His/Arg rather than His/His.	Histidine	139-142	glutathione S-transferase theta 1	Homo sapiens	20-25
17107012-3	2006	Indeed, we show here that histidine-tagged phosducin-like protein (His-PhLP) binds with high selectivity to both Ni2+-treated surface DNA and DNA-templated nickel metal to create linear protein assemblies on surfaces.	Histidine	26-35	phosducin	Homo sapiens	71-75
19912761-4	1990	Similarly, [His(5)-Trp(7)-Tyr(8)]-GnRH (chicken II) recognized the pituitary GnRH receptor, but did not bind to hippocampal membranes.	Histidine	12-15	gonadotropin releasing hormone 1	Rattus norvegicus	34-38
17107012-3	2006	Indeed, we show here that histidine-tagged phosducin-like protein (His-PhLP) binds with high selectivity to both Ni2+-treated surface DNA and DNA-templated nickel metal to create linear protein assemblies on surfaces.	Histidine	67-70	phosducin	Homo sapiens	71-75
17107012-4	2006	The association of His-PhLP with DNA-templated nickel ions or metal is reversible under appropriate rinsing conditions.	Histidine	19-22	phosducin	Homo sapiens	23-27
17029360-0	2006	Metal-binding thermodynamics of the histidine-rich sequence from the metal-transport protein IRT1 of Arabidopsis thaliana.	Histidine	36-45	iron-regulated transporter 1	Arabidopsis thaliana	93-97
19912761-4	1990	Similarly, [His(5)-Trp(7)-Tyr(8)]-GnRH (chicken II) recognized the pituitary GnRH receptor, but did not bind to hippocampal membranes.	Histidine	12-15	gonadotropin releasing hormone 1	Rattus norvegicus	77-81
17029360-6	2006	Although Fe2+ and other IRT1-transported metal ions do not bind very tightly, this His-rich sequence has a very high entropy-driven affinity for Fe3+, which may have biological significance.	Histidine	83-86	iron-regulated transporter 1	Arabidopsis thaliana	24-28
2114285-5	1990	Similar to other serine proteinases, the coding sequence of the preproacrosin gene is spread over all the five exons of the gene and the three activesite residues His, Asp and Ser are encoded by three different exons.	Histidine	163-166	acrosin	Homo sapiens	64-77
16487754-1	2006	Insulinoma associated-1 (INSM1, formerly IA-1) is a Cys(2)-His(2) zinc finger transcription factor sharing conserved regions with Caenorhabditis elegans EGL-46 and Drosophila Nerfin-1.	Histidine	59-62	insulinoma-associated 1b	Danio rerio	25-30
2201868-6	1990	ArcB conserved a histidine residue for autophosphorylation of the sensor proteins, and aspartic residues important for the regulator proteins.	Histidine	17-26	hypothetical protein	Escherichia coli	0-4
16756512-10	2006	We also present evidence that histidine and aspartic acid residues in the Lag motif are essential for the function of Lag1p in vivo.	Histidine	30-39	sphingosine N-acyltransferase LAG1	Saccharomyces cerevisiae S288C	118-123
2334429-3	1990	This mutation results in an amino-acid replacement of a conserved arginine by histidine at the residue "173," which is involved in an anion-binding site at the P-axis of LDH subunits.	Histidine	78-87	lactate dehydrogenase B	Homo sapiens	170-173
16835243-1	2006	Hint1 is a member of the evolutionarily conserved family of histidine triad proteins that acts as a haplo-insufficient tumor suppressor inducing spontaneous tumor formation in Hint+/- and Hint-/- mouse models.	Histidine	60-69	histidine triad nucleotide binding protein 1	Mus musculus	0-5
16835243-1	2006	Hint1 is a member of the evolutionarily conserved family of histidine triad proteins that acts as a haplo-insufficient tumor suppressor inducing spontaneous tumor formation in Hint+/- and Hint-/- mouse models.	Histidine	60-69	histidine triad nucleotide binding protein 1	Mus musculus	0-4
1688798-3	1990	Furthermore, addition of a poly(histidine) affinity label at the amino terminus of the reverse-transcriptase-coding sequence (His-p66) permits a simple, rapid purification of milligram quantities of either p66 or p66/p51 enzyme from a crude lysate by metal chelate affinity chromatography.	Histidine	32-41	DNA polymerase delta 3, accessory subunit	Homo sapiens	130-133
16835243-1	2006	Hint1 is a member of the evolutionarily conserved family of histidine triad proteins that acts as a haplo-insufficient tumor suppressor inducing spontaneous tumor formation in Hint+/- and Hint-/- mouse models.	Histidine	60-69	histidine triad nucleotide binding protein 1	Mus musculus	176-180
17087066-1	2006	Recombinant antigen ORF2 from porcine circovirus type 2 (PCV-2) was produced, by using the baculovirus expression system, with histidine tags to allow purification by metal-chelate affinity chromatography.	Histidine	127-136	capsid protein	Porcine circovirus 2	20-24
1688798-3	1990	Furthermore, addition of a poly(histidine) affinity label at the amino terminus of the reverse-transcriptase-coding sequence (His-p66) permits a simple, rapid purification of milligram quantities of either p66 or p66/p51 enzyme from a crude lysate by metal chelate affinity chromatography.	Histidine	32-41	DNA polymerase delta 3, accessory subunit	Homo sapiens	206-209
16787919-0	2006	His-384 allotypic variant of factor H associated with age-related macular degeneration has different heparin binding properties from the non-disease-associated form.	Histidine	0-3	complement factor H	Homo sapiens	29-37
1688798-3	1990	Furthermore, addition of a poly(histidine) affinity label at the amino terminus of the reverse-transcriptase-coding sequence (His-p66) permits a simple, rapid purification of milligram quantities of either p66 or p66/p51 enzyme from a crude lysate by metal chelate affinity chromatography.	Histidine	32-41	DNA polymerase delta 3, accessory subunit	Homo sapiens	206-209
1688798-3	1990	Furthermore, addition of a poly(histidine) affinity label at the amino terminus of the reverse-transcriptase-coding sequence (His-p66) permits a simple, rapid purification of milligram quantities of either p66 or p66/p51 enzyme from a crude lysate by metal chelate affinity chromatography.	Histidine	32-41	tumor protein p63	Homo sapiens	217-220
1688798-3	1990	Furthermore, addition of a poly(histidine) affinity label at the amino terminus of the reverse-transcriptase-coding sequence (His-p66) permits a simple, rapid purification of milligram quantities of either p66 or p66/p51 enzyme from a crude lysate by metal chelate affinity chromatography.	Histidine	126-129	DNA polymerase delta 3, accessory subunit	Homo sapiens	130-133
16893175-4	2006	Plant hxHbs contain a conserved Phe at position B10 (Phe(B10)), which is near the reversibly coordinated distal His(E7).	Histidine	112-115	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	48-51
1688798-3	1990	Furthermore, addition of a poly(histidine) affinity label at the amino terminus of the reverse-transcriptase-coding sequence (His-p66) permits a simple, rapid purification of milligram quantities of either p66 or p66/p51 enzyme from a crude lysate by metal chelate affinity chromatography.	Histidine	126-129	DNA polymerase delta 3, accessory subunit	Homo sapiens	206-209
16893175-4	2006	Plant hxHbs contain a conserved Phe at position B10 (Phe(B10)), which is near the reversibly coordinated distal His(E7).	Histidine	112-115	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	57-60
1688798-3	1990	Furthermore, addition of a poly(histidine) affinity label at the amino terminus of the reverse-transcriptase-coding sequence (His-p66) permits a simple, rapid purification of milligram quantities of either p66 or p66/p51 enzyme from a crude lysate by metal chelate affinity chromatography.	Histidine	126-129	DNA polymerase delta 3, accessory subunit	Homo sapiens	206-209
1688798-3	1990	Furthermore, addition of a poly(histidine) affinity label at the amino terminus of the reverse-transcriptase-coding sequence (His-p66) permits a simple, rapid purification of milligram quantities of either p66 or p66/p51 enzyme from a crude lysate by metal chelate affinity chromatography.	Histidine	126-129	tumor protein p63	Homo sapiens	217-220
1688798-4	1990	Purified His-p66 and His-p66/His-p51 reverse transcriptase exhibit both reverse transcriptase and RNase H activity.	Histidine	9-12	DNA polymerase delta 3, accessory subunit	Homo sapiens	13-16
16644091-0	2006	A density functional theory study on the role of His-107 in arylamine N-acetyltransferase 2 acetylation.	Histidine	49-52	N-acetyltransferase 2	Homo sapiens	60-91
1688798-4	1990	Purified His-p66 and His-p66/His-p51 reverse transcriptase exhibit both reverse transcriptase and RNase H activity.	Histidine	21-24	DNA polymerase delta 3, accessory subunit	Homo sapiens	25-28
1688798-4	1990	Purified His-p66 and His-p66/His-p51 reverse transcriptase exhibit both reverse transcriptase and RNase H activity.	Histidine	21-24	tumor protein p63	Homo sapiens	33-36
1688798-4	1990	Purified His-p66 and His-p66/His-p51 reverse transcriptase exhibit both reverse transcriptase and RNase H activity.	Histidine	21-24	DNA polymerase delta 3, accessory subunit	Homo sapiens	25-28
1688798-4	1990	Purified His-p66 and His-p66/His-p51 reverse transcriptase exhibit both reverse transcriptase and RNase H activity.	Histidine	21-24	tumor protein p63	Homo sapiens	33-36
2183181-4	1990	By use of a series of deletion mutants of Ski synthesized in an in vitro translation system, two portions in Ski were found to be necessary for the DNA binding of the Ski complex: the N-proximal portion containing a cystein/histidine-rich domain and the C-terminal portion including a region rich in basic amino acids.	Histidine	224-233	SKI proto-oncogene	Homo sapiens	109-112
16684569-1	2006	The normally hexa coordinate ferrous form of neuroglobin binds CO by replacement of the heme-linked distal histidine residue.	Histidine	107-116	neuroglobin	Homo sapiens	45-56
2155360-2	1990	ACE and dipeptidase activities were measured fluorometrically in homogenates of the developing chick retina using Hip-His-Leu and His-Leu as substrates, respectively, both either in the presence or in the absence of 1 mM PCMB.	Histidine	118-121	angiotensin I converting enzyme	Gallus gallus	0-3
2294398-0	1990	A putative transmembrane protein with histidine-rich charge clusters encoded in the H-2K/tw5 region of mice.	Histidine	38-47	histocompatibility 2, K1, K region	Mus musculus	84-88
33821889-8	2021	Based on spectroscopic, kinetic, and electrochemical studies, we deduce that DOPA residue, when present within the distal pocket of mutant Mb, alone serves the role of His/Arg-pair of peroxidases.	Histidine	168-171	myoglobin	Homo sapiens	139-141
16702225-4	2006	These studies reveal that binding of a pY peptide to the N-SH2 domain of SHP-2 is greatly enhanced by a large hydrophobic residue (Trp, Tyr, Met, or Phe) at the pY+4 and/or pY+5 positions, whereas binding to SHP-1 N-SH2 domain is enhanced by either hydrophobic or positively charged residues (Arg, Lys, or His) at these positions.	Histidine	306-309	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	73-78
16629640-0	2006	Evidence for allosteric regulation of pH-sensitive System A (SNAT2) and System N (SNAT5) amino acid transporter activity involving a conserved histidine residue.	Histidine	143-152	solute carrier family 38 member 2	Homo sapiens	61-66
16749776-11	2006	The fastest catalyst was the threonine mutant A3C ((Ac-His-Thr)8(Dap-His-Thr)4(Dap-His-Thr)2Dap-His-Thr-NH2), with kcat = 1.3 min(-1), kcat/k(uncat) = 90"000, KM = 160 microM for 8-bytyryloxypyrene 1,3,6-trisulfonate, corresponding to a rate acceleration of 18"000 per catalytic site and a 5-fold improvement over the original sequence A3.	Histidine	55-58	apolipoprotein B mRNA editing enzyme catalytic subunit 3C	Homo sapiens	46-49
33588277-8	2021	The copper(II) binding affinity of the native fragment of tau protein is comparable to that of a similar 2-histidine fragment of amyloid-beta mutant, Ac-SGAEGHHQK-NH2 but the comparison with an independent histidyl residue (H32) from the N-terminal region of the protein reveals the predominance of H32 over the histidines in the R3 domain.	Histidine	312-322	microtubule associated protein tau	Homo sapiens	58-61
16547001-0	2006	Aprataxin forms a discrete branch in the HIT (histidine triad) superfamily of proteins with both DNA/RNA binding and nucleotide hydrolase activities.	Histidine	46-55	aprataxin	Homo sapiens	0-9
16547001-8	2006	Finally, comparison of sequence relationships between the histidine triad superfamily members shows that Aprataxin forms a distinct branch in this superfamily.	Histidine	58-67	aprataxin	Homo sapiens	105-114
16647063-0	2006	A critical role for the histidine residues in the catalytic function of acyl-CoA:cholesterol acyltransferase catalysis: evidence for catalytic difference between ACAT1 and ACAT2.	Histidine	24-33	acetyl-CoA acetyltransferase 2	Homo sapiens	172-177
16647063-7	2006	These results demonstrate that the histidine residues located at the active site are very crucial both for the catalytic activity of the enzyme and for distinguishing ACAT1 from ACAT2 with respect to enzyme catalysis and substrate specificity.	Histidine	35-44	acetyl-CoA acetyltransferase 2	Homo sapiens	178-183
11939778-0	2002	Structural dynamics of distal histidine replaced mutants of myoglobin accompanied with the photodissociation reaction of the ligand.	Histidine	30-39	myoglobin	Homo sapiens	60-69
16702384-5	2006	ADH2 His/Arg and Arg/Arg genotypes showed higher risk for habitual drinking.	Histidine	5-8	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	0-4
11939778-1	2002	Protein dynamics observed by the transient grating (TG) method are studied for some site-directed mutants at the distal histidine of myoglobin (H64L, H64Q, H64V).	Histidine	120-129	myoglobin	Homo sapiens	133-142
16784457-2	2006	A variety of dicarboxylic acid linkers introduced between the alpha-amino group of His(6) and the epsilon-amino group of Lys(10) lead to high-affinity, selective human melanocortin receptor-1 and -5 (hMC1R and hMC5R) antagonists.	Histidine	83-86	melanocortin 5 receptor	Homo sapiens	210-215
34811564-3	2021	As a proof-of-concept, two systems were studied: (i) chondroitin sulfate (CS) functionalized with His, and (ii) an elastin-like peptide (ELP) containing His produced by recombinant techniques.	Histidine	153-156	nuclear receptor subfamily 5 group A member 1	Homo sapiens	115-135
34811564-3	2021	As a proof-of-concept, two systems were studied: (i) chondroitin sulfate (CS) functionalized with His, and (ii) an elastin-like peptide (ELP) containing His produced by recombinant techniques.	Histidine	153-156	nuclear receptor subfamily 5 group A member 1	Homo sapiens	137-140
16289913-5	2006	The expression of all subunits increased with increase in infection time up to 72 h. We have also over expressed three mutant forms of eIF2alpha viz, S51A, S51D, and S48A in which the serine at 51 or 48 position is replaced by an alanine or aspartic acid with 6x histidine tag at the N-terminus.	Histidine	263-272	eukaryotic translation initiation factor 2A	Homo sapiens	135-144
34811564-5	2021	The molecular structure and physicochemical properties of ELP-His and other 5 ELPs with photooxidizable amino acids were studied in silica by computer simulation.	Histidine	62-65	nuclear receptor subfamily 5 group A member 1	Homo sapiens	58-61
34676891-8	2021	Sentinel GH-clade ORF3a:p.Q57H constricted ion-channel through inter-transmembrane-domain interaction of cysteine(C81)-histidine(H57) and GR-clade N:p.RG203-204KR would stabilize RNA interaction by a more flexible and hypo-phosphorylated SR-rich region.	Histidine	119-128	gamma-glutamyl hydrolase	Homo sapiens	9-11
16584196-6	2006	This pK(H) is low for alkaline conformers involving lysine-heme ligation but is consistent with the pK(a) of the highest of three ionizable groups which modulate formation of the histidine-heme alkaline conformer of a His 73 variant of iso-1-cytochrome c [Martinez, R. E., and Bowler, B. E. (2004) J.	Histidine	179-188	eukaryotic translation initiation factor 1	Homo sapiens	236-241
16584196-6	2006	This pK(H) is low for alkaline conformers involving lysine-heme ligation but is consistent with the pK(a) of the highest of three ionizable groups which modulate formation of the histidine-heme alkaline conformer of a His 73 variant of iso-1-cytochrome c [Martinez, R. E., and Bowler, B. E. (2004) J.	Histidine	218-221	eukaryotic translation initiation factor 1	Homo sapiens	236-241
34676891-8	2021	Sentinel GH-clade ORF3a:p.Q57H constricted ion-channel through inter-transmembrane-domain interaction of cysteine(C81)-histidine(H57) and GR-clade N:p.RG203-204KR would stabilize RNA interaction by a more flexible and hypo-phosphorylated SR-rich region.	Histidine	119-128	ORF3a protein	Severe acute respiratory syndrome coronavirus 2	18-23
16602729-7	2006	The polymers were used to purify residues 230-534 of the histidine-tagged breast cancer susceptibility protein his6-BRCA1.	Histidine	57-66	BRCA1 DNA repair associated	Homo sapiens	116-121
34495791-5	2021	In this work, we have investigated In Silico dynamical aspects of the bi-directional communications by performing classical molecular dynamics (MD) simulations upon developing the necessary force field parameters for the cysteine and histidine bound hexa-coordinated Heme.	Histidine	234-243	hexosaminidase subunit alpha	Homo sapiens	250-254
16407305-7	2006	The results indicate that the lactonase activity of PON1 and PON3 and the esterase activity of PON1 are mediated by the His(115)-His(134) dyad.	Histidine	120-123	paraoxonase 3	Homo sapiens	61-65
16407305-7	2006	The results indicate that the lactonase activity of PON1 and PON3 and the esterase activity of PON1 are mediated by the His(115)-His(134) dyad.	Histidine	129-132	paraoxonase 3	Homo sapiens	61-65
16510609-6	2006	In the CBCS, positive associations were observed between breast cancer and smoking dose for participants with XRCC1 codon 194 Arg/Arg (P(trend) = 0.046), 399 Arg/Arg (P(trend) = 0.012), and 280 His/His or His/Arg (P(trend) = 0.047) genotypes.	Histidine	194-197	X-ray repair cross complementing 1	Homo sapiens	110-115
16510609-6	2006	In the CBCS, positive associations were observed between breast cancer and smoking dose for participants with XRCC1 codon 194 Arg/Arg (P(trend) = 0.046), 399 Arg/Arg (P(trend) = 0.012), and 280 His/His or His/Arg (P(trend) = 0.047) genotypes.	Histidine	198-201	X-ray repair cross complementing 1	Homo sapiens	110-115
16510609-6	2006	In the CBCS, positive associations were observed between breast cancer and smoking dose for participants with XRCC1 codon 194 Arg/Arg (P(trend) = 0.046), 399 Arg/Arg (P(trend) = 0.012), and 280 His/His or His/Arg (P(trend) = 0.047) genotypes.	Histidine	198-201	X-ray repair cross complementing 1	Homo sapiens	110-115
34125142-0	2021	Histidine ameliorates elastase- and lipopolysaccharide-induced lung inflammation by inhibiting the activation of the NLRP3 inflammasome.	Histidine	0-9	NLR family, pyrin domain containing 3	Mus musculus	117-122
34125142-7	2021	In addition, histidine treatment ameliorated lung inflammation by inhibiting the nucleotide-binding oligomerization domain-like receptor (NLR) family pyrin domain-containing 3 inflammasome activation both in vivo and in vitro.	Histidine	13-22	NLR family, pyrin domain containing 3	Mus musculus	81-175
34190541-9	2021	His-to-Asn and Asn-to-His mutations in the psychrophilic and mesophilic HBDH active sites, respectively, swap the single active-site position where these orthologues diverge.	Histidine	0-3	3-hydroxybutyrate dehydrogenase 1	Homo sapiens	72-76
16651828-8	2006	The present study indicates that histidine-rich material rapidly associates with newly synthesized filaments of keratin.	Histidine	33-42	keratin	Gallus gallus	112-119
16651828-9	2006	This observation suggests that histidine-labeled material contributes to the formation of long keratin filaments with axial orientation that are utilized for the elongation of barb and barbule cells.	Histidine	31-40	keratin	Gallus gallus	95-102
16717448-6	2006	For ANXA9 one SNP was located in exon 5 (A--&gt;G 951) resulting in an amino acid change from histidine to arginine.	Histidine	94-103	annexin A9	Bos taurus	4-9
34190541-9	2021	His-to-Asn and Asn-to-His mutations in the psychrophilic and mesophilic HBDH active sites, respectively, swap the single active-site position where these orthologues diverge.	Histidine	22-25	3-hydroxybutyrate dehydrogenase 1	Homo sapiens	72-76
34190541-10	2021	At 5  C, the His-to-Asn mutation in psychrophilic HBDH decreases Dkcat to 3.1, suggesting a decrease in transition-state symmetry, while the His-to-Asn mutation in mesophilic HBDH increases Dkcat to 4.4, indicating an increase in transition-state symmetry.	Histidine	141-144	3-hydroxybutyrate dehydrogenase 1	Homo sapiens	175-179
34233759-6	2021	RESULTS: Thirteen metabolites were identified as common biomarkers discriminating ob/ob mice and lepb-/- zebrafish larvae from their respective wild type controls: alanine, citrulline, ethanolamine, glutamine, glycine, histidine, isoleucine, leucine, methionine, phenylalanine, putrescine, serine and threonine.	Histidine	219-228	leptin	Mus musculus	82-84
16918475-5	2006	The determination of the X-ray crystal structure of NAT from Salmonella typhimurium led to the identification of the catalytically essential triad of residues: Cys-His-Asp, which is present in all functional NAT enzymes.	Histidine	164-167	bromodomain containing 2	Homo sapiens	52-55
16918475-5	2006	The determination of the X-ray crystal structure of NAT from Salmonella typhimurium led to the identification of the catalytically essential triad of residues: Cys-His-Asp, which is present in all functional NAT enzymes.	Histidine	164-167	bromodomain containing 2	Homo sapiens	208-211
34198626-14	2021	Additionally, His-hSCF248 decreased the doubling time, increased the proportion of S and G2/M stages in the cell cycle, and increased the c-Myc expression at a 1000-fold lower concentration than hSCF164.	Histidine	14-17	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	138-143
17046388-5	2006	Purification of different length ataxin-3 variants, including one of pathological length, is facilitated by an N-terminal hexa-histidine tag, which enables binding to a nickel-chelated agarose resin.	Histidine	127-136	ataxin 3	Homo sapiens	33-41
34397320-9	2021	Molecular docking and MDS analyses revealed that among these molecules, the tripeptide Arg-His-Trp shows a favorable binding affinity with beta2AR (-9.8 Kcal/mol).	Histidine	91-94	adenosine A2a receptor	Homo sapiens	139-146
16203134-2	2005	As a result of this study, His-modified pentapeptides with Trp were found to be more hMC4R potent than the corresponding 2-Nal analogs, novel N-caps and Gly surrogates were identified and 19 new peptides which are potent hMC4R agonists (EC(50) 1-15nM) and selective against hMC1R were discovered.	Histidine	27-30	melanocortin 4 receptor	Homo sapiens	85-90
34397320-12	2021	This unique tripeptide Arg-His-Trp is suggested to be a potential agonist of beta2AR and it may have applications in the context of various human diseases like bronchial asthma and chronic obstructive pulmonary disease (COPD).	Histidine	27-30	adenosine A2a receptor	Homo sapiens	77-84
16052286-3	2005	To identify the cleavage site of SaV ORF1, putative p70 (Pro-Pol) and p14-p70 (VPg-Pro-Pol) were expressed as N-terminal GST and C-terminal 6 x His-tag fusion proteins in Escherichia coli, and the expressed products were analyzed by SDS-PAGE and Western blotting.	Histidine	144-147	ribonuclease P/MRP subunit p14	Homo sapiens	70-73
35587229-1	2022	A convergent synthesis provided nearly perfect tau-ADP-ribosylated histidine isosteres (His*-tau-ADPr) via a copper(I)-catalyzed cycloaddition between an azido-ADP-ribosyl analogue and an oligopeptide carrying a propargyl glycine.	Histidine	88-91	microtubule associated protein tau	Homo sapiens	47-50
16274242-1	2005	The alkaline transition kinetics of a Lys 73--&gt;His (H73) variant of iso-1-cytochrome c are triggered by three ionizable groups [Martinez, R. E., and Bowler, B. E. (2004) J.	Histidine	50-53	eukaryotic translation initiation factor 1	Homo sapiens	71-76
35587229-1	2022	A convergent synthesis provided nearly perfect tau-ADP-ribosylated histidine isosteres (His*-tau-ADPr) via a copper(I)-catalyzed cycloaddition between an azido-ADP-ribosyl analogue and an oligopeptide carrying a propargyl glycine.	Histidine	88-91	microtubule associated protein tau	Homo sapiens	93-96
35158417-4	2022	After targeting and permeating BBB, the histidine units in the DPH chelate excess metal ions at the extracellular microenvironment, restraining the formation of Abeta aggregates, and induce the first-stage separation.	Histidine	40-49	amyloid beta (A4) precursor protein	Mus musculus	161-166
15943582-5	2005	Individual mutation of the ten histidine residues to asparagine in the catalytic domain of murine GPI-PLD resulted in three general phenotypes: not secreted or retained (His56 or His88), secreted with catalytic activity (His34, His81, His98 or His219) and secreted without catalytic activity (His29, His125, His133 or His158).	Histidine	31-40	glycosylphosphatidylinositol specific phospholipase D1	Mus musculus	98-105
16142924-1	2005	The rat organic cation transporter rOCT1 with six histidine residues added to the C-terminus was expressed in Sf9 insect cells, and expression of organic cation transport was demonstrated.	Histidine	50-59	solute carrier family 22 member 1	Rattus norvegicus	35-40
35194938-1	2022	Prune exopolyphosphatase-1 (PRUNE1) encodes a member of the aspartic acid-histidine-histidine (DHH) phosphodiesterase superfamily that regulates cell migration and proliferation during brain development.	Histidine	74-83	prune exopolyphosphatase 1	Homo sapiens	0-26
16084396-4	2005	Isoelectric focusing (IEF) and Western analyses indicated that the apparent V(max)=192+/-13 U/mg and K(m) (PDK-Tide)=55+/-10 microM of purified His(6)-PDK1 results from a mixture of at least three different phospho-specific isoforms (pI values of 6.8, 6.5, and 6.4).	Histidine	144-147	pyruvate dehydrogenase kinase 1	Homo sapiens	151-155
15761875-3	2005	Besides this side reaction, the failure of N(alpha)-Boc deprotection from the His(pi-Bom) residue occurs during TFA treatment for the standard solid-phase peptide synthesis (SPPS) even in the case of a non "difficult sequence".	Histidine	78-81	BOC cell adhesion associated, oncogene regulated	Homo sapiens	52-55
35194938-1	2022	Prune exopolyphosphatase-1 (PRUNE1) encodes a member of the aspartic acid-histidine-histidine (DHH) phosphodiesterase superfamily that regulates cell migration and proliferation during brain development.	Histidine	74-83	prune exopolyphosphatase 1	Homo sapiens	28-34
35194938-1	2022	Prune exopolyphosphatase-1 (PRUNE1) encodes a member of the aspartic acid-histidine-histidine (DHH) phosphodiesterase superfamily that regulates cell migration and proliferation during brain development.	Histidine	84-93	prune exopolyphosphatase 1	Homo sapiens	0-26
35194938-1	2022	Prune exopolyphosphatase-1 (PRUNE1) encodes a member of the aspartic acid-histidine-histidine (DHH) phosphodiesterase superfamily that regulates cell migration and proliferation during brain development.	Histidine	84-93	prune exopolyphosphatase 1	Homo sapiens	28-34
35609862-4	2022	The C-terminal cytosolic domain of mitoNEET binds a (2Fe-2S) cluster via three cysteine and one histidine residues.	Histidine	96-105	CDGSH iron sulfur domain 1	Homo sapiens	35-43
15761875-5	2005	Reviewing the removability of the Boc group on amino acid derivatives showed that the group on the His(pi-Bom) residue was much more resistant under the deprotecting conditions than expected.	Histidine	99-102	BOC cell adhesion associated, oncogene regulated	Homo sapiens	34-37
35304453-3	2022	The bacterial GE OtCE15A possesses a classical yet distinctive catalytic machinery, with easily identifiable catalytic Ser/His completed by two acidic residues (Glu and Asp) rather than one as in the classical triad, and an Arg side chain participating in the oxyanion hole.	Histidine	123-126	assembly factor for spindle microtubules	Homo sapiens	169-172
16000726-3	2005	An E. coli IroD protein with an N-terminal His-tag cleaved cyclic salmochelin S4 to the linear trimer salmochelin S2, the dimer salmochelin S1, and the monomers dihydroxybenzoylserine and C-glucosylated dihydroxybenzoylserine (salmochelin SX, pacifarinic acid).	Histidine	43-46	IroD	Escherichia coli	11-15
35280336-1	2022	Purpose: In order to overcome the biological barriers at all levels and enhance the delivery efficiency of siRNA, we have prepared a multifunctional siRNA delivery system (CHCE/siRNA nanoparticles) through self-assembly of the carboxymethyl chitosan modified with histidine, cholesterol, and anti-EGFR antibody (CHCE).	Histidine	264-273	epidermal growth factor receptor	Mus musculus	297-301
15870096-0	2005	ALBINO AND PALE GREEN 10 encodes BBMII isomerase involved in histidine biosynthesis in Arabidopsis thaliana.	Histidine	61-70	Aldolase-type TIM barrel family protein	Arabidopsis thaliana	33-48
15870096-3	2005	The morphological abnormality of apg10 was recovered by histidine supplementation.	Histidine	56-65	Aldolase-type TIM barrel family protein	Arabidopsis thaliana	33-38
35090891-11	2022	We propose a novel and detailed mechanism by which the two His-Met-Asp residues of hCTR1 amino-terminus not only bind copper, but also maintain its reduced state crucial for intracellular uptake.	Histidine	59-62	solute carrier family 31 member 1	Homo sapiens	83-88
15870096-4	2005	The histidine limitation induced by apg10 mutation causes dynamic changes of the free amino acid profile, suggesting the existence of a cross-pathway regulatory mechanism of amino acid biosynthesis in plants.	Histidine	4-13	Aldolase-type TIM barrel family protein	Arabidopsis thaliana	36-41
35210360-6	2022	COA7 binds heme with micromolar affinity, through axial ligation to the central iron atom by histidine and methionine residues.	Histidine	93-102	cytochrome c oxidase assembly factor 7	Homo sapiens	0-4
16029163-1	2005	Human brain serine racemase (hSR) was expressed in large amounts in E. coli with N-terminal His-tag (His-hSR).	Histidine	92-95	HSR	Homo sapiens	29-32
16029163-1	2005	Human brain serine racemase (hSR) was expressed in large amounts in E. coli with N-terminal His-tag (His-hSR).	Histidine	101-104	HSR	Homo sapiens	29-32
16029163-1	2005	Human brain serine racemase (hSR) was expressed in large amounts in E. coli with N-terminal His-tag (His-hSR).	Histidine	101-104	HSR	Homo sapiens	105-108
16029163-3	2005	Purified His-hSR was refolded in Tween 20/cycloamylose with approximately 50% efficiency, and refolded His-hSR was isolated by Q Sepharose column chromatography.	Histidine	9-12	HSR	Homo sapiens	13-16
16029163-3	2005	Purified His-hSR was refolded in Tween 20/cycloamylose with approximately 50% efficiency, and refolded His-hSR was isolated by Q Sepharose column chromatography.	Histidine	9-12	HSR	Homo sapiens	107-110
16029163-5	2005	His-hSR catalyzed the elimination of L-Ser as well as L-Ser-O-sulfate to form pyruvate.	Histidine	0-3	HSR	Homo sapiens	4-7
35140838-4	2022	Herein, we have investigated the role of MC1R activation with BMS-470539 in attenuating oxidative stress and neuronal apoptosis induced by HI and the underlying mechanisms.	Histidine	139-141	melanocortin 1 receptor	Rattus norvegicus	41-45
15790557-3	2005	Disease-associated mutations in Aprataxin target a histidine triad domain that is similar to Hint, a universally conserved AMP-lysine hydrolase, or truncate the protein NH2-terminal to a zinc finger.	Histidine	51-60	aprataxin	Homo sapiens	32-41
2684616-7	1989	From these results it is concluded that histidine at position 7 of GLP-1 as a free N-terminal amino acid is very important in GLP-1"s insulinotropic activity and probably in glucagon-inhibiting activity, and that C-terminal amidation and three C-terminal amino acids are less important for these activities.	Histidine	40-49	glucagon	Rattus norvegicus	67-72
15749695-1	2005	The active site glutamate (Glu(111)) and the active site histidine (His(112)) of insulin-degrading enzyme (IDE) were mutated.	Histidine	57-66	insulin degrading enzyme	Homo sapiens	81-105
15749695-1	2005	The active site glutamate (Glu(111)) and the active site histidine (His(112)) of insulin-degrading enzyme (IDE) were mutated.	Histidine	57-66	insulin degrading enzyme	Homo sapiens	107-110
15749695-1	2005	The active site glutamate (Glu(111)) and the active site histidine (His(112)) of insulin-degrading enzyme (IDE) were mutated.	Histidine	68-71	insulin degrading enzyme	Homo sapiens	81-105
15749695-1	2005	The active site glutamate (Glu(111)) and the active site histidine (His(112)) of insulin-degrading enzyme (IDE) were mutated.	Histidine	68-71	insulin degrading enzyme	Homo sapiens	107-110
15771721-2	2005	Two other SNPs (CRH A145G and C240G) occur in the propeptide region at residue positions 45 and 77, respectively, that result in serine/asparagine and histidine/aspartic acid substitutions respectively.	Histidine	151-160	corticotropin releasing hormone	Bos taurus	16-19
15574419-1	2005	To compare kinetic properties of homologous isozymes of NADP+-specific isocitrate dehydrogenase, histidine-tagged forms of yeast mitochondrial (IDP1) and cytosolic (IDP2) enzymes were expressed and purified.	Histidine	97-106	isocitrate dehydrogenase (NADP(+)) IDP1	Saccharomyces cerevisiae S288C	144-148
15691328-6	2005	The deduced amino acid sequence showed full conservation of five His residues and one Met residue, which bind two Cu atoms that are essential for the activity of PHM.	Histidine	65-68	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	162-165
15668381-4	2005	The structures confirm that SABP2 is a member of the alpha/beta hydrolase superfamily of enzymes, with Ser-81, His-238, and Asp-210 as the catalytic triad.	Histidine	111-114	salicylic acid-binding protein 2	Nicotiana tabacum	28-33
15692735-3	2005	This report describes the optimisation of 6-fluorotryptophan incorporation in a His-tagged human serum retinol-binding protein (RBP), a disulphide bonded beta-barrel protein.	Histidine	80-83	retinol binding protein 4	Homo sapiens	128-131
15561858-5	2004	PCR amplified a blaKPC allele encoding a novel variant, KPC-3, with a His(272)--&gt;Tyr substitution not found in KPC-2; other carbapenemase genes were absent.	Histidine	70-73	KPC-3	Klebsiella pneumoniae	56-61
15358768-3	2004	It has been previously shown that a subfamily 1 Arabidopsis thaliana ethylene receptor, ETR1, autophosphorylates in vitro on a conserved histidine residue (1).	Histidine	137-146	Signal transduction histidine kinase, hybrid-type, ethylene sensor	Arabidopsis thaliana	88-92
15358768-8	2004	ERS1, the only other subfamily 1 receptor, is able to phosphorylate on both histidine and serine residues in the presence of Mn2+.	Histidine	76-85	ethylene response sensor 1	Arabidopsis thaliana	0-4
15358768-9	2004	However, histidine autophosphorylation is lost when ERS1 is assayed in the presence of both Mg2+ and Mn2+, suggesting that this activity may not occur in vivo.	Histidine	9-18	ethylene response sensor 1	Arabidopsis thaliana	52-56
15479231-0	2004	Investigation of the contribution of histidine 119 to the conduction of protons through human Nox2.	Histidine	37-46	cytochrome b-245 beta chain	Homo sapiens	94-98
15479231-3	2004	To investigate the possible role that these histidine residues might play in the conduction of protons through Nox2, we have introduced both paired and single mutations into these histidine residues.	Histidine	44-53	cytochrome b-245 beta chain	Homo sapiens	111-115
15479231-3	2004	To investigate the possible role that these histidine residues might play in the conduction of protons through Nox2, we have introduced both paired and single mutations into these histidine residues.	Histidine	180-189	cytochrome b-245 beta chain	Homo sapiens	111-115
15475297-4	2004	The domains found in Graal proteins are: chitin-binding domains (CBD), scavenger receptor cysteine-rich (SRCR) domains, low density lipoprotein receptor cysteine-rich (LDLR-CR) domains, histidine and proline-rich domains, a NGGYQPP-repeat domain and a serine protease domain.	Histidine	186-195	Tequila	Drosophila melanogaster	21-26
15226312-8	2004	In this way, the structural determinants of regioselectivity in FAT-1 and FAT-2 have been localized to two interdependent regions: a relatively hydrophobic region between the first two histidine boxes and the carboxyl-terminal region.	Histidine	185-194	Omega-3 fatty acid desaturase fat-1	Caenorhabditis elegans	64-69
15226312-8	2004	In this way, the structural determinants of regioselectivity in FAT-1 and FAT-2 have been localized to two interdependent regions: a relatively hydrophobic region between the first two histidine boxes and the carboxyl-terminal region.	Histidine	185-194	Delta(12) fatty acid desaturase fat-2	Caenorhabditis elegans	74-79
15366949-7	2004	Two such labeling reagents were designed, synthesized, and used to modify both N- and C-terminally His-tagged versions of the enzyme murine dihydrofolate reductase (mDHFR).	Histidine	99-102	dihydrofolate reductase	Mus musculus	165-170
15336487-7	2004	The 56 kDa MobA was expressed in E. coli as a (6x)His-Tag fusion protein.	Histidine	50-53	plasmid mobilization protein	Escherichia coli	11-15
15265919-5	2004	Molecular modeling of mouse mast cell protease 6 identified four His residues, H35, H106, H108, and H238, that are conserved among pH-dependent tryptases and are exposed on the molecular surface, and these four His residues were mutated to Ala.	Histidine	65-68	tryptase beta 2	Mus musculus	28-48
15265919-5	2004	Molecular modeling of mouse mast cell protease 6 identified four His residues, H35, H106, H108, and H238, that are conserved among pH-dependent tryptases and are exposed on the molecular surface, and these four His residues were mutated to Ala.	Histidine	211-214	tryptase beta 2	Mus musculus	28-48
15269838-1	2004	The anti-angiogenic properties of the histidine-proline-rich (H/P) domain of HPRG have recently been described (Juarez JC, et al.	Histidine	38-47	histidine rich glycoprotein	Homo sapiens	77-81
15087452-3	2004	The deduced 371-amino-acid sequence shares 68% identity with human CtsW and includes the conserved catalytic triad cysteine, histidine, and asparagine found in all members of this family.	Histidine	125-134	cathepsin W	Homo sapiens	67-71
15165238-3	2004	Here, we show that mutations in two essential VirA residues, His-474 and Gly-657, can be complemented by the formation of mixed heterodimers, indicating that each subunit of a VirA dimer transphosphorylates the opposite subunit.	Histidine	61-64	two-component VirA-like sensor kinase	Agrobacterium tumefaciens	46-50
15165238-3	2004	Here, we show that mutations in two essential VirA residues, His-474 and Gly-657, can be complemented by the formation of mixed heterodimers, indicating that each subunit of a VirA dimer transphosphorylates the opposite subunit.	Histidine	61-64	two-component VirA-like sensor kinase	Agrobacterium tumefaciens	176-180
15020597-1	2004	Neuroglobin, recently discovered in the brain and in the retina of vertebrates, belongs to the class of hexacoordinate globins, in which the distal histidine coordinates the iron center in both the Fe(II) and Fe(III) forms.	Histidine	148-157	neuroglobin	Homo sapiens	0-11
15128298-6	2004	The coding sequences were expressed in Escherichia coli as six-histidine tagged recombinant proteins and generated products with molecular masses of 86.1 kDa for HSP and 22.4 kDa for MnSOD.	Histidine	63-72	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	162-165
15604682-9	2004	Both (His)6-ACBP4 and (His)6-ACBP5 bind [14C]oleoyl-CoA with high affinity, [14C]palmitoyl-CoA with lower affinity and did not bind [14C]arachidonyl-CoA.	Histidine	23-26	acyl-CoA binding protein 5	Arabidopsis thaliana	29-34
14672930-3	2004	We systematically mutated all the histidine and cysteine residues in Sdh3p and Sdh4p to identify the residues involved in axial heme ligation.	Histidine	34-43	succinate dehydrogenase membrane anchor subunit SDH4	Saccharomyces cerevisiae S288C	79-84
14759599-11	2004	Protonation of His-64 in Mb enhances HN3 binding due to a gating mechanism while protonation of His-52 in CcP decreases the affinity for HN3 due to loss of base-assisted association of the ligand to the heme iron.	Histidine	96-99	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	106-109
15000850-2	2004	Hybridomas were screened by indirect enzyme-linked immunosorbent assay (ELISA) using either purified 6 x His-ZNRD1fusion protein or purified 6 x His-OS-9 fusion protein as a control.	Histidine	105-108	RNA polymerase I subunit H	Homo sapiens	109-114
14523020-1	2003	We created a molecular model of the human melanocortin 4 receptor (MC4R) and introduced a series of His residues into the receptor protein to form metal ion binding sites.	Histidine	100-103	melanocortin 4 receptor	Homo sapiens	42-65
14645567-3	2003	The ts138 mutant possessed a change of G4303 to C, predicting an Ala68-to-Gly alteration that altered a conserved His-Ala-Val tripeptide in the ancient (pre-eukaryotic), "X" or histone 2A phosphoesterase-like macrodomain that in SIN encompasses nsP3 residues 1 to 161 and whose role is unknown.	Histidine	114-117	SH2 domain containing 3C	Homo sapiens	245-249
14719827-2	2003	A gene encoding for chicken ovalbumin (Gad dI) was isolated from chicken oviduct by PCR amplification and was cloned under the control of T5 promoter fused with a six-histidine tag at the N-terminal end.	Histidine	167-176	ovalbumin (SERPINB14)	Gallus gallus	28-37
12959987-10	2003	In conclusion, L-His can potentiate both GLP-1R- and CaSR-activated signaling pathways, and these effects may play a role in the potentiation of glucose-induced insulin secretion in response to meals containing protein in addition to carbohydrates and fat.	Histidine	15-20	glucagon-like peptide 1 receptor	Rattus norvegicus	41-48
12959987-10	2003	In conclusion, L-His can potentiate both GLP-1R- and CaSR-activated signaling pathways, and these effects may play a role in the potentiation of glucose-induced insulin secretion in response to meals containing protein in addition to carbohydrates and fat.	Histidine	15-20	calcium-sensing receptor	Rattus norvegicus	53-57
12869545-2	2003	We generated mice with a point mutation in the thyroid hormone receptor alpha (TRalpha) gene producing a dominant-negative TRalpha mutant receptor with a proline to histidine substitution (P398H).	Histidine	165-174	guanine nucleotide binding protein, alpha transducing 1	Mus musculus	79-86
14555798-3	2003	Because of the competition of Pr(III) for ligands with Ca(II), the percentages of free Ca2+, [Ca(Lac)], and [Ca(His)(Thr)H3] increase gradually and the percentages of CaHPO4(aq) and [Ca(Cit)(His)H2] decrease gradually with the increase in the total concentration of Pr(III).	Histidine	112-115	carbonic anhydrase 2	Homo sapiens	55-61
14555798-3	2003	Because of the competition of Pr(III) for ligands with Ca(II), the percentages of free Ca2+, [Ca(Lac)], and [Ca(His)(Thr)H3] increase gradually and the percentages of CaHPO4(aq) and [Ca(Cit)(His)H2] decrease gradually with the increase in the total concentration of Pr(III).	Histidine	191-194	carbonic anhydrase 2	Homo sapiens	55-61
14550642-5	2003	For efficient expression and purification, we cloned the cDNAs corresponding to proteolytically processed forms of LOX (LOX-p) and LOXL (LOXL-p1 and LOXL-p2) into a bacterial expression vector pET21a with six continuous histidine codons attached to the 3" of the gene.	Histidine	220-229	lysyl oxidase	Homo sapiens	115-118
12796496-4	2003	Wild type CDH is only the second example of a b-type heme with Met-His ligation, and it is the first example of a Met-His ligation of heme b where the ligands are arranged in a nearly perpendicular orientation.	Histidine	67-70	choline dehydrogenase	Homo sapiens	10-13
12716883-3	2003	Following intracellular overexpression in fusion with a histidine affinity tag in Escherichia coli, purification under denaturing conditions, and removal of denaturant through dialysis, retro-HSP12.6 was found to fold to a soluble state.	Histidine	56-65	SHSP domain-containing protein	Caenorhabditis elegans	192-199
12837291-6	2003	However, the responses of the two templates differ mechanistically in that the CREB-binding protein p300 potentiates activation from the transient template in a manner dependent on its Cys/His-rich region 3, but does not appear to affect the repression of the replicating chromatin template.	Histidine	189-192	cAMP responsive element binding protein 1	Homo sapiens	79-83
12810953-1	2003	PKC-interacting protein (PKCI), also designated histidine triad nucleotide-binding protein 1, belongs to the histidine triad (HIT) family of proteins.	Histidine	48-57	protein kinase C, iota	Mus musculus	0-23
12810953-1	2003	PKC-interacting protein (PKCI), also designated histidine triad nucleotide-binding protein 1, belongs to the histidine triad (HIT) family of proteins.	Histidine	48-57	protein kinase C, iota	Mus musculus	25-29
12748294-0	2003	The histidine triad protein Hint is not required for murine development or Cdk7 function.	Histidine	4-13	histidine triad nucleotide binding protein 1	Mus musculus	28-32
12748294-1	2003	The histidine triad (HIT) protein Hint has been found to associate with mammalian Cdk7, as well as to interact both physically and genetically with the budding yeast Cdk7 homologue Kin28.	Histidine	4-13	histidine triad nucleotide binding protein 1	Mus musculus	34-38
12814263-2	2003	A hexa-histidine tag was also added to the C-terminus of RBP for ease of purification.	Histidine	7-16	retinol binding protein 4	Homo sapiens	57-60
12814271-3	2003	Cu(II)-IMAC was found to be highly selective for histidine containing peptides; moreover, a low degree of nonspecific selection was observed.	Histidine	49-58	C-C motif chemokine ligand 26	Homo sapiens	0-11
12766799-3	2003	For example, histidine-168 and tyrosine-332 equivalent to positions 170 and 333 in other mammalian GHRs, which were considered to be necessary for the dimerization of GHR and the specific GH-stimulated functions respectively, were replaced by tyrosine and serine in gpGHR.	Histidine	13-22	growth hormone receptor	Homo sapiens	99-102
12551905-0	2003	The role of the invariant His-1069 in folding and function of the Wilson"s disease protein, the human copper-transporting ATPase ATP7B.	Histidine	26-29	ATPase copper transporting beta	Homo sapiens	129-134
12654781-8	2003	Recombinant His-tagged Ecgp blocked E. coli invasion efficiently by binding directly to the bacteria.	Histidine	12-15	heat shock protein 90 beta family member 1	Homo sapiens	23-27
12631327-4	2003	The more efficient putative carrier, AtmBAC1, was expressed in E. coli, purified, and reconstituted into phospholipid vesicles, where it transported the basic l-amino acids arginine, lysine, ornithine and histidine (in order of decreasing affinity).	Histidine	205-214	Mitochondrial substrate carrier family protein	Arabidopsis thaliana	37-44
12631327-5	2003	AtmBAC1 recognized l-histidine whereas both yeast Ort1p and the mammalian ortholog ORNT1p do not.	Histidine	19-30	Mitochondrial substrate carrier family protein	Arabidopsis thaliana	0-7
12501240-9	2003	Individual mutation of His-64, His-228, or His-352 in GIRK4 abolished or greatly diminished the inhibition in homomeric GIRK4.	Histidine	23-26	potassium inwardly rectifying channel subfamily J member 5	Homo sapiens	120-125
12501240-9	2003	Individual mutation of His-64, His-228, or His-352 in GIRK4 abolished or greatly diminished the inhibition in homomeric GIRK4.	Histidine	31-34	potassium inwardly rectifying channel subfamily J member 5	Homo sapiens	54-59
12501240-9	2003	Individual mutation of His-64, His-228, or His-352 in GIRK4 abolished or greatly diminished the inhibition in homomeric GIRK4.	Histidine	31-34	potassium inwardly rectifying channel subfamily J member 5	Homo sapiens	120-125
12501240-9	2003	Individual mutation of His-64, His-228, or His-352 in GIRK4 abolished or greatly diminished the inhibition in homomeric GIRK4.	Histidine	31-34	potassium inwardly rectifying channel subfamily J member 5	Homo sapiens	54-59
12501240-9	2003	Individual mutation of His-64, His-228, or His-352 in GIRK4 abolished or greatly diminished the inhibition in homomeric GIRK4.	Histidine	31-34	potassium inwardly rectifying channel subfamily J member 5	Homo sapiens	120-125
12501240-10	2003	Mutations of any of these histidine residues in GIRK4 or their counterparts in GIRK1 were sufficient to eliminate the pH(i) sensitivity of the heteromeric GIRK1/GIRK4 channels.	Histidine	26-35	potassium inwardly rectifying channel subfamily J member 5	Homo sapiens	48-53
12501240-10	2003	Mutations of any of these histidine residues in GIRK4 or their counterparts in GIRK1 were sufficient to eliminate the pH(i) sensitivity of the heteromeric GIRK1/GIRK4 channels.	Histidine	26-35	potassium inwardly rectifying channel subfamily J member 5	Homo sapiens	161-166
12581208-10	2003	EPR of the nitrosyl heme complex has established the nitrogenous proximal ligand, presumably histidine 17 and the obtained EPR parameters are discriminated from those of the rat heme oxygenase-1 complex.	Histidine	93-102	heme oxygenase 1	Rattus norvegicus	178-194
12444763-0	2002	Providing a chemical basis toward understanding the histidine base-on motif of methylcobalamin-dependent methionine synthase: an improved purification of methylcobinamide, plus thermodynamic studies of methylcobinamide binding exogenous imidazole and pyridine bases.	Histidine	52-61	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	105-124
12553726-6	2002	The data give strong evidence that the unique C-tail of S100A9 containing the three consecutive histidine residues (His103-His105) represents the region to which the fatty acid carboxy-group is bound to the protein complex.	Histidine	96-105	S100 calcium binding protein A9	Homo sapiens	56-62
12457963-8	2002	A cluster of eight histidine residues was found in proximity to the last transmembrane domain of Cyno-EBV LMP1 and was exploited as a natural protein tag in expression studies.	Histidine	19-28	PDZ and LIM domain 7	Homo sapiens	106-110
12361957-9	2002	Such activation was eliminated when a histidine residue in the M1-H5 linker was mutated to a non-titratable glutamine, i.e. H116Q in GIRK1 and H120Q in GIRK4.	Histidine	38-47	potassium inwardly rectifying channel subfamily J member 3 S homeolog	Xenopus laevis	133-138
12163504-3	2002	Two-dimensional crystals of Pgp in a lipid bilayer were generated by reconstituting pure, detergent-solubilized protein containing a C-terminal six-histidine tag using the lipid monolayer technique.	Histidine	148-157	phosphoglycolate phosphatase	Mus musculus	28-31
12237460-7	2002	For ILBP, on the other hand, a more solvent-accessible protein cavity was deduced based on the pH titration behavior of its histidine residues.	Histidine	124-133	fatty acid binding protein 6	Homo sapiens	4-8
12356468-3	2002	PCR methodologies were used to subclone the gene encoding the functional Delta(3)-Delta(2)-enoyl-CoA isomerase from pAG847 with primers that were designed to add six continuous histidine codon to the 5(") primer.	Histidine	177-186	enoyl-CoA delta isomerase 1	Rattus norvegicus	73-110
12224952-8	2002	The most potent compound 1n with the pharmacophore motif "His-DPhe-Arg-Trp" was identified as having an EC(50) value of 165 nM at mMC1R, 7600 nM at mMC3R, 650 nM at mMC4R, and 335 nM at mMC5R.	Histidine	58-61	melanocortin 3 receptor	Mus musculus	148-153
12204228-4	2002	Recombinant six-histidine tagged schistosome thioredoxin had insulin reduction activity and supported the enzymatic function of thioredoxin reductase and thioredoxin peroxidase.	Histidine	16-25	thioredoxin 1	Mus musculus	45-56
12204228-4	2002	Recombinant six-histidine tagged schistosome thioredoxin had insulin reduction activity and supported the enzymatic function of thioredoxin reductase and thioredoxin peroxidase.	Histidine	16-25	thioredoxin 1	Mus musculus	128-139
12204228-4	2002	Recombinant six-histidine tagged schistosome thioredoxin had insulin reduction activity and supported the enzymatic function of thioredoxin reductase and thioredoxin peroxidase.	Histidine	16-25	thioredoxin 1	Mus musculus	128-139
12146983-3	2002	Here, we investigate topological effects on loop formation probabilities in denatured iso-1-cytochrome c by comparing histidine-heme binding affinities for histidines on the N- versus the C-terminal side of the heme.	Histidine	118-127	eukaryotic translation initiation factor 1	Homo sapiens	86-91
12146983-3	2002	Here, we investigate topological effects on loop formation probabilities in denatured iso-1-cytochrome c by comparing histidine-heme binding affinities for histidines on the N- versus the C-terminal side of the heme.	Histidine	156-166	eukaryotic translation initiation factor 1	Homo sapiens	86-91
12167347-6	2002	In this study, full-length DEN2 NS3 was expressed with an N-terminal histidine tag in Escherichia coli and purified in a soluble form.	Histidine	69-78	KRAS proto-oncogene, GTPase	Homo sapiens	32-35
12139236-2	2002	There are at least two known alleles of MIC-1 that are due to a G--&gt;C point substitution at position 6 of the mature protein, which alters a histidine to an aspartic acid (MIC-1 H and MIC-1 D).	Histidine	144-153	growth differentiation factor 15	Homo sapiens	40-45
12139236-2	2002	There are at least two known alleles of MIC-1 that are due to a G--&gt;C point substitution at position 6 of the mature protein, which alters a histidine to an aspartic acid (MIC-1 H and MIC-1 D).	Histidine	144-153	growth differentiation factor 15	Homo sapiens	175-180
12139236-2	2002	There are at least two known alleles of MIC-1 that are due to a G--&gt;C point substitution at position 6 of the mature protein, which alters a histidine to an aspartic acid (MIC-1 H and MIC-1 D).	Histidine	144-153	growth differentiation factor 15	Homo sapiens	175-180
12056811-1	2002	Histidyl-tRNA synthetase catalyses the covalent ligation of histidine to its cognate tRNA as an early step in protein biosynthesis.	Histidine	60-69	histidyl-tRNA synthetase 1	Homo sapiens	0-24
12071694-1	2002	BfpA, the structural repeating protein subunit A of the bundle-forming pilus and EspB, a type-III-secreted pore-forming protein of enteropathogenic Escherichia coli (EPEC), both virulence factors central for EPEC pathogenesis, were overexpressed in E. coli DH5alpha and M15 laboratory strains, respectively, using the pQE-30 cloning expression system, as chimeric fusions to a NH(2)-terminal histidine hexapeptide (His(6)-tag) sequence.	Histidine	392-401	Major pilin structural unit bundlin	Escherichia coli	0-4
11893736-0	2002	Importance of the histidine ligand to coenzyme B12 in the reaction catalyzed by methylmalonyl-CoA mutase.	Histidine	18-27	methylmalonyl-CoA mutase	Homo sapiens	80-104
11896050-5	2002	rMCP-4 was expressed with an N-terminal His tag followed by an enterokinase site substituting for the native activation peptide.	Histidine	40-43	mast cell protease 4	Rattus norvegicus	0-6
11916859-6	2002	The histidine-modifying reagent, diethyl pyrocarbonate, reversibly blocks cx50 hemichannel currents but not cx46 hemichannel currents.	Histidine	4-13	gap junction protein alpha 8	Homo sapiens	74-78
11916859-7	2002	Because cx46 and cx50 have very similar amino acid sequences, one might expect that replacing the two histidines unique to the third transmembrane region of cx50 with the corresponding cx46 residues would produce mutants more closely resembling cx46.	Histidine	102-112	gap junction protein alpha 8	Homo sapiens	17-21
11916859-7	2002	Because cx46 and cx50 have very similar amino acid sequences, one might expect that replacing the two histidines unique to the third transmembrane region of cx50 with the corresponding cx46 residues would produce mutants more closely resembling cx46.	Histidine	102-112	gap junction protein alpha 8	Homo sapiens	157-161
11948105-10	2002	The most active immunotoxin contained amino acid residues Thr-His-Trp (THW) in place of Ser-Ser-Tyr (SSY) at positions 100, 100A, and 100B of the Fv and had an affinity improved from 85 nM to 6 nM.	Histidine	62-65	p53 apoptosis effector related to PMP22	Homo sapiens	71-74
11922758-2	2002	The hH4 cDNA was subcloned into the pQE30 expression vector, in frame with a sequence encoding an N-terminal stretch of six histidine residues.	Histidine	124-133	prokineticin 2	Homo sapiens	4-7
11741896-6	2002	In GIRK4/GIRK1 heteromers the GIRK4 His-64 and Leu-268 residues showed greater contributions to G beta zeta sensitivity than did the corresponding GIRK1 His-57 and Leu-262 residues.	Histidine	36-39	potassium inwardly rectifying channel subfamily J member 5	Homo sapiens	3-8
11741896-6	2002	In GIRK4/GIRK1 heteromers the GIRK4 His-64 and Leu-268 residues showed greater contributions to G beta zeta sensitivity than did the corresponding GIRK1 His-57 and Leu-262 residues.	Histidine	36-39	potassium inwardly rectifying channel subfamily J member 5	Homo sapiens	30-35
11785967-0	2002	Modification of histidine (B10) is the causative agent for a superactive form of insulin.	Histidine	16-25	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	27-30
11785967-3	2002	It was found that the insulin was bound to the resin through histidine B10, His (B10), and its ammonium bicarbonate-mediated release resulted in an insulin analog in which His (B10) was modified on the imidazole ring.	Histidine	61-70	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	71-74
11785967-3	2002	It was found that the insulin was bound to the resin through histidine B10, His (B10), and its ammonium bicarbonate-mediated release resulted in an insulin analog in which His (B10) was modified on the imidazole ring.	Histidine	76-79	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	81-84
11785967-3	2002	It was found that the insulin was bound to the resin through histidine B10, His (B10), and its ammonium bicarbonate-mediated release resulted in an insulin analog in which His (B10) was modified on the imidazole ring.	Histidine	76-79	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	81-84
11785967-6	2002	Since Asp (B10) insulin is also superactive, the observed superactivity may thus stem from either modification of the histidine or its conversion to aspartic acid.	Histidine	118-127	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	11-14
11784781-6	2002	Cu toxicity induced by human APP, Xenopus APP, and APLP2 CuBDs is dependent on conservation of histidine residues at positions corresponding to 147 and 151 of human APP.	Histidine	95-104	amyloid beta (A4) precursor-like protein 2 L homeolog	Xenopus laevis	51-56
11782367-7	2002	Transient expression of dominant-negative p53 ((175)Arg--&gt;His) counteracted the detrimental effects of BPDE on BRCA-1 promoter activity and protein levels.	Histidine	61-64	BRCA1 DNA repair associated	Homo sapiens	114-120
11739191-2	2001	A 68.5-kd chimeric protein (His-M195FANCF) was expressed, consisting of a His tag, a single-chain antibody to the myeloid antigen CD33, and the FANCF protein, as well as a 43-kd His-FANCF fusion protein lacking the antibody motif, in Escherichia coli.	Histidine	28-31	FA complementation group F	Homo sapiens	36-41
11739191-2	2001	A 68.5-kd chimeric protein (His-M195FANCF) was expressed, consisting of a His tag, a single-chain antibody to the myeloid antigen CD33, and the FANCF protein, as well as a 43-kd His-FANCF fusion protein lacking the antibody motif, in Escherichia coli.	Histidine	28-31	FA complementation group F	Homo sapiens	144-149
11739191-3	2001	The nickel-agarose-purified His-M195FANCF protein bound specifically to the surface of HeLa cells transfected with CD33 and internalized through vesicular structures.	Histidine	28-31	FA complementation group F	Homo sapiens	36-41
11739191-7	2001	The intracellular half-life of His-M195FANCF was approximately 160 minutes.	Histidine	31-34	FA complementation group F	Homo sapiens	39-44
11739191-8	2001	Treatment of CD33-transfected FA group F lymphoblastoid cells with 0.1 mg/mL His-M195FANCF conferred resistance to mitomycin C.	Histidine	77-80	FA complementation group F	Homo sapiens	85-90
11673563-9	2001	Furthermore, a point-mutated Dsg3 molecule containing Dsg1-specific amino acid substitutions (His(25), Cys(28), Ala(29)) reacted with anti-Dsg1 IgG, thus defining one of the epitopes of Dsg1.	Histidine	94-97	desmoglein 3	Mus musculus	29-33
11673563-9	2001	Furthermore, a point-mutated Dsg3 molecule containing Dsg1-specific amino acid substitutions (His(25), Cys(28), Ala(29)) reacted with anti-Dsg1 IgG, thus defining one of the epitopes of Dsg1.	Histidine	94-97	desmoglein 1 alpha	Mus musculus	54-58
11673563-9	2001	Furthermore, a point-mutated Dsg3 molecule containing Dsg1-specific amino acid substitutions (His(25), Cys(28), Ala(29)) reacted with anti-Dsg1 IgG, thus defining one of the epitopes of Dsg1.	Histidine	94-97	desmoglein 1 alpha	Mus musculus	139-143
11673563-9	2001	Furthermore, a point-mutated Dsg3 molecule containing Dsg1-specific amino acid substitutions (His(25), Cys(28), Ala(29)) reacted with anti-Dsg1 IgG, thus defining one of the epitopes of Dsg1.	Histidine	94-97	desmoglein 1 alpha	Mus musculus	139-143
11570891-2	2001	Diethyl pyrocarbonate inhibits the reaction of cytochrome b(561) with ascorbate by modifying a histidine residue in the ascorbate-binding site.	Histidine	95-104	mitochondrially encoded cytochrome b	Homo sapiens	47-59
11570891-10	2001	(1) The ascorbate monoanion binds to an unprotonated site (histidine) on cytochrome b(561).	Histidine	59-68	mitochondrially encoded cytochrome b	Homo sapiens	73-85
11371582-5	2001	Also, human growth hormone receptor (GHR) displays species specificity; i.e., it can interact only with human (or rhesus monkey) GH, not with nonprimate GHS: The species specificity of human GHR is largely due to the Leu--&gt;Arg change at position 43, and it has been hypothesized that this change must have been preceded by the His--&gt;Asp change at position 171 of GH.	Histidine	330-333	growth hormone receptor	Homo sapiens	12-35
11371582-5	2001	Also, human growth hormone receptor (GHR) displays species specificity; i.e., it can interact only with human (or rhesus monkey) GH, not with nonprimate GHS: The species specificity of human GHR is largely due to the Leu--&gt;Arg change at position 43, and it has been hypothesized that this change must have been preceded by the His--&gt;Asp change at position 171 of GH.	Histidine	330-333	growth hormone receptor	Homo sapiens	37-40
11371582-5	2001	Also, human growth hormone receptor (GHR) displays species specificity; i.e., it can interact only with human (or rhesus monkey) GH, not with nonprimate GHS: The species specificity of human GHR is largely due to the Leu--&gt;Arg change at position 43, and it has been hypothesized that this change must have been preceded by the His--&gt;Asp change at position 171 of GH.	Histidine	330-333	growth hormone receptor	Homo sapiens	191-194
11278524-3	2001	We genetically modified the C terminus of hIL-18BP by appending a 15-amino acid biotinylation recognition site and a six-histidine tag and then performed site-directed mutagenesis to determine the functional epitopes that mediate efficient binding to IL-18.	Histidine	121-130	interleukin 18	Homo sapiens	43-48
11264014-4	2001	Heme dissociated from the reduced cyt b(5) protein at pH approximately 3.5, whereas its rate decreased under CO atmosphere compared with N(2) atmosphere, due to formation of a heme&amp;bond;CO adduct with a histidine as an axial ligand.	Histidine	207-216	mitochondrially encoded cytochrome b	Homo sapiens	34-41
20428263-2	2001	Genetic analysis of the proband found evidence for two distinct mutations of the MYH7 gene (the gene coding for the beta-myosin heavy chain): 403Arg--&gt; Trp in exon 13 and a novel mutation, 453Arg--&gt; His, in exon 14.	Histidine	205-208	myosin heavy chain 7	Homo sapiens	81-85
11115608-4	2001	NS1 bound to the two related cysteine-histidine-rich regions of CBP, referred to as C/H1 and C/H3, the former of which has an antagonistic function to CBP upon the NS1-transactivation.	Histidine	38-47	influenza virus NS1A binding protein	Homo sapiens	0-3
11115608-4	2001	NS1 bound to the two related cysteine-histidine-rich regions of CBP, referred to as C/H1 and C/H3, the former of which has an antagonistic function to CBP upon the NS1-transactivation.	Histidine	38-47	influenza virus NS1A binding protein	Homo sapiens	164-167
11123909-1	2000	Previously, we have identified three Zn(2+) binding residues in an endogenous Zn(2+) binding site in the human dopamine transporter (hDAT): (193)His in extracellular loop 2 (ECL 2), (375)His at the external end of transmembrane segment (TM) 7, and (396)Glu at the external end of TM 8.	Histidine	145-148	solute carrier family 6 member 3	Homo sapiens	111-131
11123909-1	2000	Previously, we have identified three Zn(2+) binding residues in an endogenous Zn(2+) binding site in the human dopamine transporter (hDAT): (193)His in extracellular loop 2 (ECL 2), (375)His at the external end of transmembrane segment (TM) 7, and (396)Glu at the external end of TM 8.	Histidine	145-148	tetraspanin 16	Homo sapiens	280-284
11123909-1	2000	Previously, we have identified three Zn(2+) binding residues in an endogenous Zn(2+) binding site in the human dopamine transporter (hDAT): (193)His in extracellular loop 2 (ECL 2), (375)His at the external end of transmembrane segment (TM) 7, and (396)Glu at the external end of TM 8.	Histidine	187-190	solute carrier family 6 member 3	Homo sapiens	111-131
11104674-3	2000	This tyrosine residue is conserved in most AKR family members including AKR1C1-1C3, but is replaced with histidine in AKR1C4 and phenylalanine in some AKR members.	Histidine	105-114	aldo-keto reductase family 1 member C4	Homo sapiens	118-124
11104674-9	2000	These results indicate the importance of this histidine residue in creating the cavity of the substrate-binding site of AKR1C4 through the orientation of the nicotinamide ring of the coenzyme, as well as its involvement in the conformational change by binding non-essential activators.	Histidine	46-55	aldo-keto reductase family 1 member C4	Homo sapiens	120-126
11162372-6	2000	Upon introduction of parasite CpMBF1 into S. cerevisiae, 3-amino triazole resistance of the MBF1-deficient strain was restored to wild-type levels, and Northern blot analysis revealed that CpMBF1 was able to activate HIS3 transcription in response to histidine starvation.	Histidine	251-260	imidazoleglycerol-phosphate dehydratase HIS3	Saccharomyces cerevisiae S288C	217-221
11120754-3	2000	Here, we demonstrate that PV IgGs eluted from rDsg1-Ig-His and rDsg3-Ig-His show similar antigenic profiles, including the 38-, 43-, 115-, and 190-kDa keratinocyte proteins and a non-Dsg 3 130-kDa polypeptide present in keratinocytes from Dsg 3 knockout mouse.	Histidine	55-58	desmoglein 1	Rattus norvegicus	46-51
11120754-3	2000	Here, we demonstrate that PV IgGs eluted from rDsg1-Ig-His and rDsg3-Ig-His show similar antigenic profiles, including the 38-, 43-, 115-, and 190-kDa keratinocyte proteins and a non-Dsg 3 130-kDa polypeptide present in keratinocytes from Dsg 3 knockout mouse.	Histidine	55-58	desmoglein 1	Homo sapiens	47-50
11120754-3	2000	Here, we demonstrate that PV IgGs eluted from rDsg1-Ig-His and rDsg3-Ig-His show similar antigenic profiles, including the 38-, 43-, 115-, and 190-kDa keratinocyte proteins and a non-Dsg 3 130-kDa polypeptide present in keratinocytes from Dsg 3 knockout mouse.	Histidine	72-75	desmoglein 1	Homo sapiens	64-67
11152303-0	2000	An internal histidine residue from the bacterial surface protein, PAM, mediates its binding to the kringle-2 domain of human plasminogen.	Histidine	12-21	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	66-69
11152303-2	2000	Significant kringle-induced chemical shifts in a His side-chain of a1-PAM were revealed by two-dimensional NMR.	Histidine	49-52	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	70-73
10934209-4	2000	The three-dimensional structure of the Bir3 domain of XIAP, determined by NMR spectroscopy, resembles a classical zinc finger and consists of five alpha-helices, a three-stranded beta-sheet, and a zinc atom chelated to three cysteines and one histidine.	Histidine	243-252	X-linked inhibitor of apoptosis	Homo sapiens	54-58
10998050-1	2000	A single mutation, involving the replacement of an arginine residue with histidine to reconstruct a zinc-binding site, suffices to change a catalytically inactive murine carbonic anhydrase-related protein (CARP) to an active carbonic anhydrase with a CO2-hydration turnover number of 1.2 x 104 s-1.	Histidine	73-82	carbonic anhydrase 8	Mus musculus	170-204
10969139-1	2000	alpha-amidation of a peptide (which takes place from a glycine-extended precursor) is required to produce biologically active amidated hormones, such as gastrin-releasing peptide (GRP)/Pyr-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH(2) (bombesin).	Histidine	229-232	gastrin releasing peptide	Rattus norvegicus	153-178
10969139-1	2000	alpha-amidation of a peptide (which takes place from a glycine-extended precursor) is required to produce biologically active amidated hormones, such as gastrin-releasing peptide (GRP)/Pyr-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH(2) (bombesin).	Histidine	229-232	gastrin releasing peptide	Rattus norvegicus	180-183
10913314-1	2000	The gene nirM, coding for cytochrome c-551 in Pseudomonas stutzeri substrain ZoBell, was engineered to mutate Met61, the sixth ligand to the heme c, into His61, thereby converting the typical Met-His coordination of a c-type cytochrome into His-His, typical of b-type cytochromes.	Histidine	154-157	cytochrome c3 family protein	Pseudomonas stutzeri	26-38
10913314-1	2000	The gene nirM, coding for cytochrome c-551 in Pseudomonas stutzeri substrain ZoBell, was engineered to mutate Met61, the sixth ligand to the heme c, into His61, thereby converting the typical Met-His coordination of a c-type cytochrome into His-His, typical of b-type cytochromes.	Histidine	196-199	cytochrome c3 family protein	Pseudomonas stutzeri	26-38
10913314-1	2000	The gene nirM, coding for cytochrome c-551 in Pseudomonas stutzeri substrain ZoBell, was engineered to mutate Met61, the sixth ligand to the heme c, into His61, thereby converting the typical Met-His coordination of a c-type cytochrome into His-His, typical of b-type cytochromes.	Histidine	196-199	cytochrome c3 family protein	Pseudomonas stutzeri	26-38
10862049-5	2000	Two mutations in the CDKN2A (p16) gene were detected, including a novel base change AAC--&gt;ATC (Asn to Ile) at codon 71, that also changes the codon 85 of the alternative reading frame gene p14(ARF) from CAA to CAT (Gln to His).	Histidine	225-228	glycine-N-acyltransferase	Homo sapiens	84-87
10915606-3	2000	Our study provides experimental evidence that histidine at position 1658 and aspartic acid at position 1686 constitute together with the previously identified serine at position 1752 (S1752) the catalytic triad of the pestiviral NS3 serine protease.	Histidine	46-55	KRAS proto-oncogene, GTPase	Homo sapiens	229-232
10898935-5	2000	AtUBP5 was active without 311 amino acids N-terminal to the active site cysteine, or without 233 nonconserved amino acids between the Cys and His boxes, or without both, indicating the core region was sufficient.	Histidine	142-145	ubiquitin-specific protease 5	Arabidopsis thaliana	0-6
10872755-0	2000	Metal-catalyzed oxidation of brain-derived neurotrophic factor (BDNF): selectivity and conformational consequences of histidine modification.	Histidine	118-127	brain derived neurotrophic factor	Homo sapiens	29-62
10872755-0	2000	Metal-catalyzed oxidation of brain-derived neurotrophic factor (BDNF): selectivity and conformational consequences of histidine modification.	Histidine	118-127	brain derived neurotrophic factor	Homo sapiens	64-68
10704983-0	2000	Enthalpy and enzyme activity of modified histidine residues of adenosine deaminase and diethyl pyrocarbonate complexes.	Histidine	41-50	adenosine deaminase	Homo sapiens	63-82
10704983-1	2000	Kinetic and thermodynamic studies have been made on the effect of diethyl pyrocarbonate as a histidine modifier on the active site of adenosine deaminase in 50 mM sodium phosphate buffer pH 6.8, at 27 degrees C using UV spectrophotometry and isothermal titration calorimetry (ITC).	Histidine	93-102	adenosine deaminase	Homo sapiens	134-153
10704983-3	2000	The number of modified histidine residues complexed to active site of adenosine deaminase are equivalent to 4.	Histidine	23-32	adenosine deaminase	Homo sapiens	70-89
10686340-0	2000	Identification of specific histidine residues and the carboxyl terminus are essential for serotonin N-acetyltransferase enzymatic activity.	Histidine	27-36	aralkylamine N-acetyltransferase	Homo sapiens	90-119
10692054-2	2000	We report the expression in Chinese hamster ovary (CHO) cells of a modified mouse CD59 cDNA that had been truncated at D-74, resulting in the loss of the glycosylphosphatidyl inositol (GPI) anchor, and containing six additional C-terminal histidines.	Histidine	239-249	CD59a antigen	Mus musculus	82-86
10663563-9	2000	Mature pig IL-5 was expressed in Escherichia coli with a His-tag for purification.	Histidine	57-60	interleukin 5	Sus scrofa	11-15
10567440-4	1999	The antigen was recombinant hTS containing an N-terminal His(6)-tag.	Histidine	57-60	APC down-regulated 1	Homo sapiens	28-31
10715790-2	1999	METHODS: E2/NS1 gene derived from HCV was inserted into expression vector containing six His tag.	Histidine	89-92	influenza virus NS1A binding protein	Homo sapiens	12-15
10510299-8	1999	Competition experiments with positively charged poly(amino acids) furthermore suggested that histidine, arginine and lysine residues in LPL are important for the interaction between LDL and LPL.	Histidine	93-102	lipoprotein lipase	Mus musculus	136-139
10510299-8	1999	Competition experiments with positively charged poly(amino acids) furthermore suggested that histidine, arginine and lysine residues in LPL are important for the interaction between LDL and LPL.	Histidine	93-102	lipoprotein lipase	Mus musculus	190-193
10582345-1	1999	Basic Kruppel-like Factor (BKLF) is a recently recognized member of a small group of transcription factors that bind CACCC motifs in DNA, by means of three highly conserved C-terminal Kruppel-like (typically Cys-X2-4-Cys-X12-His-X3-4-His) zinc fingers.	Histidine	234-237	Kruppel-like factor 3 (basic)	Mus musculus	0-25
10582345-1	1999	Basic Kruppel-like Factor (BKLF) is a recently recognized member of a small group of transcription factors that bind CACCC motifs in DNA, by means of three highly conserved C-terminal Kruppel-like (typically Cys-X2-4-Cys-X12-His-X3-4-His) zinc fingers.	Histidine	234-237	Kruppel-like factor 3 (basic)	Mus musculus	27-31
10537216-4	1999	These proteins also showed 40-60% identity to the delta9-desaturases (Ole1p) of other fungi and contained the three conserved histidine boxes, C-terminal cytochrome b5 fusion and transmembrane domains characteristic of endoplasmic reticulum membrane-bound delta9-desaturases.	Histidine	126-135	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	70-75
2684616-7	1989	From these results it is concluded that histidine at position 7 of GLP-1 as a free N-terminal amino acid is very important in GLP-1"s insulinotropic activity and probably in glucagon-inhibiting activity, and that C-terminal amidation and three C-terminal amino acids are less important for these activities.	Histidine	40-49	glucagon	Rattus norvegicus	126-131
2804130-0	1989	Chemical properties of the histidine residue of secretin: evidence for a specific intramolecular interaction.	Histidine	27-36	secretin	Homo sapiens	48-56
10493777-5	1999	RESULTS: Sorbinil binds to the active site of aldehyde reductase and is hydrogen-bonded to Trp 22, Tyr 50, His 113, and the non-conserved Arg 312.	Histidine	107-110	aldo-keto reductase family 1 member A1	Homo sapiens	46-64
2804130-1	1989	Secretin has a single histidine residue located at the amino terminus which plays a crucial role in its biological activity.	Histidine	22-31	secretin	Homo sapiens	0-8
10610126-4	1999	In this study, we characterized, in vitro, the putative cytokinin-responsive CKI1 His-kinase, in terms of His-Asp phosphorelays.	Histidine	82-85	casein kinase I	Arabidopsis thaliana	77-81
2613237-2	1989	A mutation of thymine to adenine in the prealbumin (transthyretin) gene at the position corresponding to the second base of codon 58 in the prealbumin mRNA gives a histidine for leucine substitution in the plasma protein.	Histidine	164-173	transthyretin	Homo sapiens	52-65
10428989-0	1999	Characterization of C-terminal histidine-tagged human recombinant lecithin:cholesterol acyltransferase.	Histidine	31-40	lecithin-cholesterol acyltransferase	Homo sapiens	66-102
10428989-8	1999	We conclude that carboxy-terminal histidine-tagged LCAT is a suitable replacement for both plasma LCAT and CHO-hLCAT.	Histidine	34-43	lecithin-cholesterol acyltransferase	Homo sapiens	51-55
2558710-3	1989	By use of 500-MHz proton NMR spectroscopy, it has been possible to identify the C-H resonances of the nonaxial histidines of trypsin-solubilized bovine, rabbit, and porcine cytochrome b5 and therefore observe the interaction of DEP with specific histidine residues of cytochrome b5.	Histidine	111-121	cytochrome b5	Oryctolagus cuniculus	173-186
10428989-8	1999	We conclude that carboxy-terminal histidine-tagged LCAT is a suitable replacement for both plasma LCAT and CHO-hLCAT.	Histidine	34-43	lecithin-cholesterol acyltransferase	Homo sapiens	98-102
2558710-3	1989	By use of 500-MHz proton NMR spectroscopy, it has been possible to identify the C-H resonances of the nonaxial histidines of trypsin-solubilized bovine, rabbit, and porcine cytochrome b5 and therefore observe the interaction of DEP with specific histidine residues of cytochrome b5.	Histidine	111-121	cytochrome b5	Oryctolagus cuniculus	268-281
10409731-1	1999	Mutations in SSY1 and PTR3 were identified in a genetic selection for components required for the proper uptake and compartmentalization of histidine in Saccharomyces cerevisiae.	Histidine	140-149	Ssy1p	Saccharomyces cerevisiae S288C	13-17
2558710-3	1989	By use of 500-MHz proton NMR spectroscopy, it has been possible to identify the C-H resonances of the nonaxial histidines of trypsin-solubilized bovine, rabbit, and porcine cytochrome b5 and therefore observe the interaction of DEP with specific histidine residues of cytochrome b5.	Histidine	111-120	cytochrome b5	Oryctolagus cuniculus	173-186
10409731-1	1999	Mutations in SSY1 and PTR3 were identified in a genetic selection for components required for the proper uptake and compartmentalization of histidine in Saccharomyces cerevisiae.	Histidine	140-149	Ptr3p	Saccharomyces cerevisiae S288C	22-26
10409731-7	1999	ssy1 and ptr3 mutants have increased vacuolar pools of histidine and arginine and exhibit altered cell growth morphologies accompanied by exaggerated invasive growth.	Histidine	55-64	Ssy1p	Saccharomyces cerevisiae S288C	0-4
2558710-3	1989	By use of 500-MHz proton NMR spectroscopy, it has been possible to identify the C-H resonances of the nonaxial histidines of trypsin-solubilized bovine, rabbit, and porcine cytochrome b5 and therefore observe the interaction of DEP with specific histidine residues of cytochrome b5.	Histidine	111-120	cytochrome b5	Oryctolagus cuniculus	268-281
10409731-7	1999	ssy1 and ptr3 mutants have increased vacuolar pools of histidine and arginine and exhibit altered cell growth morphologies accompanied by exaggerated invasive growth.	Histidine	55-64	Ptr3p	Saccharomyces cerevisiae S288C	9-13
2558710-4	1989	In addition, the pKa of the peripheral histidines of bovine and rabbit cytochrome b5 have been measured in D2O.	Histidine	39-49	cytochrome b5	Oryctolagus cuniculus	71-84
2614645-1	1989	A novel inhibitor of angiotensin-converting enzyme (ACE) derived from tuna muscle, Pro-Thr-His-Ile-Lys-Trp-Gly-Asp (tuna AI), was chemically synthesized, and its biological properties were investigated.	Histidine	91-94	angiotensin-converting enzyme	Oryctolagus cuniculus	52-55
10413479-11	1999	These data suggest that the hydrophobic cluster in CAII is important for orienting the histidine residues to stabilize metals bound with a distorted tetrahedral geometry and to destabilize the trigonal bipyramidal geometry of bound copper.	Histidine	87-96	carbonic anhydrase 2	Homo sapiens	51-55
2542963-12	1989	Comparison of the N2O reductase sequence, determined by translating the structural NosZ gene, with cytochrome c oxidase subunit II sequences from several sources indicates that a Gly-Xaa-Xaa-Xaa-Xaa-Xaa-Cys-Ser-Xaa-Xaa-Cys-Xaa-Xaa-Xaa-His stretch is highly conserved.	Histidine	235-238	cytochrome c oxidase subunit II	Pseudomonas stutzeri	99-130
10450831-4	1999	The second homologue (STC2) is 30-38% identical to the fish stanniocalcins, and is characterized by unique cysteine and histidine motifs that are not found in the other stanniocalcins.	Histidine	120-129	stanniocalcin 2	Homo sapiens	22-26
10410979-3	1999	Employing this method, a recombinant C3a (rC3a) anaphylatoxin with a His-tag at its N-terminus could be shown to bind to C3a receptor (C3aR)-expressing RBL-2H3 transfectants with a half-maximal effective concentration (EC50) of about 3 nM which is well within the range of published affinity constants.	Histidine	69-72	complement C3	Homo sapiens	37-40
10383764-5	1999	VirB4 also dimerized in Agrobacterium tumefaciens, as demonstrated by the recovery of a detergent-resistant complex of native protein and a functional, histidine-tagged derivative by precipitation with anti-His6 antibodies and by Co2+ affinity chromatography.	Histidine	152-161	type IV secretion system protein VirB4	Agrobacterium tumefaciens	0-5
2662962-2	1989	IMAC of proteins on transition metals (Co, Ni, Cu, Zn) can be rationalized in terms of the coordination of histidine residues.	Histidine	107-116	C-C motif chemokine ligand 26	Homo sapiens	0-4
10386883-3	1999	A single-chain form of the NS3/NS4A complex (His-NS4A21-32-GSGS-NS3-631) was constructed in which the NS4A core peptide is fused to the N-terminus of the NS3 protease domain as previously described (Taremi et al., 1998).	Histidine	45-48	KRAS proto-oncogene, GTPase	Homo sapiens	27-30
10386883-3	1999	A single-chain form of the NS3/NS4A complex (His-NS4A21-32-GSGS-NS3-631) was constructed in which the NS4A core peptide is fused to the N-terminus of the NS3 protease domain as previously described (Taremi et al., 1998).	Histidine	45-48	KRAS proto-oncogene, GTPase	Homo sapiens	64-67
10386883-3	1999	A single-chain form of the NS3/NS4A complex (His-NS4A21-32-GSGS-NS3-631) was constructed in which the NS4A core peptide is fused to the N-terminus of the NS3 protease domain as previously described (Taremi et al., 1998).	Histidine	45-48	KRAS proto-oncogene, GTPase	Homo sapiens	64-67
2650908-3	1989	Using oligonucleotide probes we have shown that the N-ras gene is activated by a point mutation at the third base of codon 61 resulting in the substitution of histidine for glutamine in the p21 ras gene product.	Histidine	159-168	NRAS proto-oncogene, GTPase	Homo sapiens	52-57
2742853-6	1989	Carboxymethylation of His-13 or His-114 with bromoacetate increases the Ki value 15-fold, and oxidation of Trp-89 by means of dimethyl sulfoxide and hydrochloric acid increases it 2.4-fold, suggesting that these residues also form part of the contact region with PRI.	Histidine	22-25	ribonuclease/angiogenin inhibitor 1	Homo sapiens	263-266
2742853-6	1989	Carboxymethylation of His-13 or His-114 with bromoacetate increases the Ki value 15-fold, and oxidation of Trp-89 by means of dimethyl sulfoxide and hydrochloric acid increases it 2.4-fold, suggesting that these residues also form part of the contact region with PRI.	Histidine	32-35	ribonuclease/angiogenin inhibitor 1	Homo sapiens	263-266
2742853-9	1989	These results indicate that PRI inhibition minimally involves the three residues critical for the activity of angiogenin--Lys-40, His-13, and His-114--and to a lesser extent its single tryptophan, Trp-89.	Histidine	130-133	ribonuclease/angiogenin inhibitor 1	Homo sapiens	28-31
10329662-7	1999	The transcriptional repression function of AEBP2 was completely abolished when one of the conserved histidine residues and a flanking serine residue in the middle zinc finger were replaced with an arginine residue.	Histidine	100-109	AE binding protein 2	Mus musculus	43-48
10329662-9	1999	Moreover, both the wild-type and mutant derivative of either the histidine-tagged recombinant AEBP2 proteins or the in vitro translated Gal4-AEBP2 fusion proteins were equally able to bind to the target DNA.	Histidine	65-74	AE binding protein 2	Mus musculus	94-99
2742853-9	1989	These results indicate that PRI inhibition minimally involves the three residues critical for the activity of angiogenin--Lys-40, His-13, and His-114--and to a lesser extent its single tryptophan, Trp-89.	Histidine	142-145	ribonuclease/angiogenin inhibitor 1	Homo sapiens	28-31
2645047-6	1989	Both tumors were found to be mutated in the 61st N-ras codon from gln to his.	Histidine	73-76	NRAS proto-oncogene, GTPase	Homo sapiens	49-54
10206982-1	1999	Currents through the human skeletal muscle chloride channel hClC-1 can be blocked by external application of 1 mM Zn2+ or the histidine-reactive compound diethyl pyrocarbonate (DEPC).	Histidine	126-135	chloride voltage-gated channel 1	Homo sapiens	60-66
2909523-11	1989	In a less active variant of human GH, hGH-V, only 1 residue (His-21) of the 37 residues is replaced by Tyr.	Histidine	61-64	growth hormone 2	Homo sapiens	38-43
10199784-1	1999	We produced substantial amount of the extracellular domain of the human TSH receptor (TSHRE) that has a tag of six histidines at C-terminus as a soluble form in the human cell line HeLa using a vaccinia virus system.	Histidine	115-125	thyroid stimulating hormone receptor	Homo sapiens	72-84
10199784-1	1999	We produced substantial amount of the extracellular domain of the human TSH receptor (TSHRE) that has a tag of six histidines at C-terminus as a soluble form in the human cell line HeLa using a vaccinia virus system.	Histidine	115-125	thyroid stimulating hormone receptor	Homo sapiens	86-91
10392722-4	1999	A histidine (His6) tag was introduced close to the C-terminus of the proteinase to aid purification.	Histidine	2-11	endogenous retrovirus group K member 19, envelope	Homo sapiens	69-79
2591200-2	1989	Chemical modification of essential serine, histidine and cysteine residues of porcine LCAT were accompanied by loss of enzymatic activity.	Histidine	43-52	lecithin-cholesterol acyltransferase	Homo sapiens	86-90
2488733-4	1989	NMR spectra also indicate a protonation of the histidine moiety by Ara-C.	Histidine	47-56	p21 (RAC1) activated kinase 3	Homo sapiens	67-70
10029536-8	1999	This shift results in the loss of the hydrogen bond between His 162 and Glu 296 seen in the H91N and turkey delta I crystallin structures; this H-bond is believed to be crucial for the catalytic mechanism of ASL/delta II crystallin.	Histidine	60-63	argininosuccinate lyase	Meleagris gallopavo	208-211
9922258-1	1999	The nitrogen assimilation control protein (NAC) from Klebsiella aerogenes or Escherichia coli (NACK or NACE, respectively) is a transcriptional regulator that is both necessary and sufficient to activate transcription of the histidine utilization (hut) operon and to repress transcription of the glutamate dehydrogenase (gdh) operon in K. aerogenes.	Histidine	225-234	glutamate dehydrogenase	Escherichia coli	296-319
9922258-1	1999	The nitrogen assimilation control protein (NAC) from Klebsiella aerogenes or Escherichia coli (NACK or NACE, respectively) is a transcriptional regulator that is both necessary and sufficient to activate transcription of the histidine utilization (hut) operon and to repress transcription of the glutamate dehydrogenase (gdh) operon in K. aerogenes.	Histidine	225-234	glutamate dehydrogenase	Escherichia coli	321-324
2853973-0	1988	Site-directed mutagenesis of yeast cytochrome c peroxidase shows histidine 181 is not required for oxidation of ferrocytochrome c. The long-distance electron transfer observed in the complex formed between ferrocytochrome c and compound I, the peroxide-oxidized form of cytochrome c peroxidase (CCP), has been proposed to occur through the participation of His 181 of CCP and Phe 87 of yeast iso-1 cytochrome c [Poulos, T. L., &amp; Kraut, J.	Histidine	65-74	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	35-58
10021468-7	1999	Our results demonstrate that the A-V node and the His-Purkinje regions of the conduction system are specifically compromised by DMPK loss.	Histidine	50-53	dystrophia myotonica-protein kinase	Mus musculus	128-132
2853973-0	1988	Site-directed mutagenesis of yeast cytochrome c peroxidase shows histidine 181 is not required for oxidation of ferrocytochrome c. The long-distance electron transfer observed in the complex formed between ferrocytochrome c and compound I, the peroxide-oxidized form of cytochrome c peroxidase (CCP), has been proposed to occur through the participation of His 181 of CCP and Phe 87 of yeast iso-1 cytochrome c [Poulos, T. L., &amp; Kraut, J.	Histidine	65-74	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	270-293
2853973-0	1988	Site-directed mutagenesis of yeast cytochrome c peroxidase shows histidine 181 is not required for oxidation of ferrocytochrome c. The long-distance electron transfer observed in the complex formed between ferrocytochrome c and compound I, the peroxide-oxidized form of cytochrome c peroxidase (CCP), has been proposed to occur through the participation of His 181 of CCP and Phe 87 of yeast iso-1 cytochrome c [Poulos, T. L., &amp; Kraut, J.	Histidine	65-74	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	295-298
2853973-0	1988	Site-directed mutagenesis of yeast cytochrome c peroxidase shows histidine 181 is not required for oxidation of ferrocytochrome c. The long-distance electron transfer observed in the complex formed between ferrocytochrome c and compound I, the peroxide-oxidized form of cytochrome c peroxidase (CCP), has been proposed to occur through the participation of His 181 of CCP and Phe 87 of yeast iso-1 cytochrome c [Poulos, T. L., &amp; Kraut, J.	Histidine	65-74	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	368-371
10030688-5	1998	Three of these proteins (HI-1: 36 kDa/pI 4.5, HI-10: 40 kDa/pI 5.5 and HI-19: 62 kDa/pI 5.0) exhibit a "progression-like" pattern, being induced by estradiol in MCF-7 cells and constitutively present/upregulated in the MCF-7/LCC1 growing without estradiol.	Histidine	25-27	C-C motif chemokine ligand 16	Homo sapiens	225-229
3220658-2	1988	The pKa"s of the three histidine residues in a proline-rich glycoprotein from human parotid saliva (PRG) were determined by 360 MHz proton n.m.r.	Histidine	23-32	proline rich protein BstNI subfamily 3	Homo sapiens	100-103
3220658-7	1988	Exchange lifetime data and previously reported hydrogen----deuterium exchange experiments suggest that the PRG histidine N tau H protons are not involved in hydrogen-bonds.	Histidine	111-120	proline rich protein BstNI subfamily 3	Homo sapiens	107-110
9831037-4	1998	We have introduced a histidine residue into antibody Jel 103 and converted it into an abzyme that cleaves poly(rI) with a kinetic efficiency of about 100 M(-1) sec(-1).	Histidine	21-30	secretory blood group 1, pseudogene	Homo sapiens	160-166
3391168-4	1988	It was demonstrated, on the basis of the photo-CIDNP spectrum, that one of seven histidines, all three tyrosines and a single tryptophan of the rabbit soluble cytochrome b5 are exposed on the surface of the protein.	Histidine	81-91	cytochrome b5	Oryctolagus cuniculus	159-172
9786917-3	1998	We report here that CBP, which was originally identified as a co-activator of CREB, directly binds to the b-ZIP region of ATF-2 via a Cys/His-rich region termed C/H2, and potentiates trans-activation by ATF-2.	Histidine	138-141	cAMP responsive element binding protein 1	Homo sapiens	78-82
3348809-3	1988	On the other hand, we determined the primary structure of human H-protein from the amino terminal Ser by the 12th Val, including a hexapeptide, -Glu-Lys-His-Glu-Trp-Val-.	Histidine	153-156	myosin binding protein H	Homo sapiens	64-73
9786917-3	1998	We report here that CBP, which was originally identified as a co-activator of CREB, directly binds to the b-ZIP region of ATF-2 via a Cys/His-rich region termed C/H2, and potentiates trans-activation by ATF-2.	Histidine	138-141	death associated protein kinase 3	Homo sapiens	108-111
9786917-3	1998	We report here that CBP, which was originally identified as a co-activator of CREB, directly binds to the b-ZIP region of ATF-2 via a Cys/His-rich region termed C/H2, and potentiates trans-activation by ATF-2.	Histidine	138-141	activating transcription factor 2	Homo sapiens	122-127
9724720-3	1998	Prediction of the histidylation function of the new family of minimalist tRNA-like structures relates to the geometry of resected pseudoknots that allows proper presentation to histidyl-tRNA synthetase of analogues of the histidine identity determinants N-1 and N73 present in tRNAs.	Histidine	222-231	histidyl-tRNA synthetase 1	Homo sapiens	177-201
3276685-3	1988	Using oligonucleotide-directed mutagenesis of the cloned E. coli citrate synthase gene, we prepared missense mutants, designated CS226H----Q and CS229H----Q, in which histidine residues at positions 226 and 229, respectively, were replaced by glutamine.	Histidine	167-176	citrate synthase	Sus scrofa	65-81
3478091-9	1987	It is proposed that the residue having a kinetic pKa of 5.9 is the histidine modified by diethyl pyrocarbonate and that this residue participates in general acid/base catalysis during substrate hydrolysis by neutral endopeptidase 24.11.	Histidine	67-76	membrane metallo-endopeptidase	Rattus norvegicus	208-235
9603385-8	1998	This was a substitution of G to A of the second nucleotide position of codon 124 in the betaig-h3 gene that led to a replacement of histidine for arginine (Arg124His, CGC--&gt;CAC).	Histidine	132-141	transforming growth factor beta induced	Homo sapiens	88-97
9603385-8	1998	This was a substitution of G to A of the second nucleotide position of codon 124 in the betaig-h3 gene that led to a replacement of histidine for arginine (Arg124His, CGC--&gt;CAC).	Histidine	132-141	carbonic anhydrase 2	Homo sapiens	176-179
3029126-3	1987	The activated N-ras clone has an AT to TA transversion at the third position of codon 61 which results in the insertion of histidine instead of glutamine.	Histidine	123-132	GTPase NRas	Cavia porcellus	14-19
9485405-5	1998	The side chains of S-peptide residues His-12 and Met-13 contribute a large fraction of the total interface with S-protein.	Histidine	38-41	vitronectin	Homo sapiens	112-121
3813569-2	1987	One of the histidine C-2 peaks titrated normally, with a pKa value of 6.8, but the other two histidines in this peptide had pKa values of 6.3.	Histidine	11-20	complement C2	Bos taurus	21-24
9540798-6	1998	These assays showed that chymotrypsin and elastase cleave pNiXa at the P1-P1 (Thr-Lys) peptide bond near the C-terminus, while trypsin and cathepsin G cleave pNiXa at specific peptide bonds near the N-terminus, within an interesting 26-residue segment, rich in Lys and Gln, that separates the His-cluster of pNiXa from the rest of the molecule.	Histidine	293-296	cathepsin G	Bos taurus	139-150
9480810-2	1998	It is generally accepted that the catalytic mechanism of LCAT is similar to that of serine proteases and lipases involving a Ser, a His, and an acidic amino acid residue.	Histidine	132-135	lecithin-cholesterol acyltransferase	Homo sapiens	57-61
9480810-5	1998	Alignments of LCAT sequences across various species indicate that the four histidines at positions 180, 263, 368, and 377 are conserved and could be involved in catalysis.	Histidine	75-85	lecithin-cholesterol acyltransferase	Homo sapiens	14-18
9473505-9	1998	In a hip1 tat1 double mutant, the level of histidine required for growth increased eight-fold in comparison to the hip1 single mutant.	Histidine	43-52	amino acid transporter TAT1	Saccharomyces cerevisiae S288C	10-14
9521129-2	1998	We report here the over-expression of KAP in Escherichia coli as an N-terminal His-tagged protein using a modified pET-28a T7-expression vector.	Histidine	79-82	cyclin dependent kinase inhibitor 3	Homo sapiens	38-41
9510129-0	1998	Proximal and distal histidines in thyroid peroxidase: relation to the alternatively spliced form, TPO-2.	Histidine	20-30	thyroid peroxidase	Homo sapiens	98-101
9510129-1	1998	The distal and proximal histidines in thyroid peroxidase (TPO), located by amino acid sequence alignment with their known counterparts in myeloperoxidase, are His 239 and His 494, respectively.	Histidine	24-34	thyroid peroxidase	Homo sapiens	58-61
9510129-1	1998	The distal and proximal histidines in thyroid peroxidase (TPO), located by amino acid sequence alignment with their known counterparts in myeloperoxidase, are His 239 and His 494, respectively.	Histidine	159-162	thyroid peroxidase	Homo sapiens	58-61
9510129-1	1998	The distal and proximal histidines in thyroid peroxidase (TPO), located by amino acid sequence alignment with their known counterparts in myeloperoxidase, are His 239 and His 494, respectively.	Histidine	171-174	thyroid peroxidase	Homo sapiens	58-61
9510129-2	1998	These histidines lie outside the 57 amino acid peptide (residues 533-589) that is absent in the alternatively spliced form, TPO-2.	Histidine	6-16	thyroid peroxidase	Homo sapiens	124-127
9510129-3	1998	However, asparagine 579, which very likely forms a stabilizing hydrogen bond with the proximal histidine in TPO, lies within the missing peptide region.	Histidine	95-104	thyroid peroxidase	Homo sapiens	108-111
9427740-3	1998	We have performed a systematic survey of conserved histidines in the last six transmembrane segments of the related polytopic membrane proteins PsaA and PsaB in the green alga Chlamydomonas reinhardtii.	Histidine	51-61	photosystem I P700 chlorophyll a apoprotein A2	Chlamydomonas reinhardtii	153-157
9427740-6	1998	Only mutations in the histidines of helix 10 (PsaA-His676 and PsaB-His656) resulted in changes in spectroscopic properties of P700, leading us to conclude that these histidines are most likely the axial ligands to the P700 chlorophylls.	Histidine	22-32	photosystem I P700 chlorophyll a apoprotein A2	Chlamydomonas reinhardtii	62-66
9427740-6	1998	Only mutations in the histidines of helix 10 (PsaA-His676 and PsaB-His656) resulted in changes in spectroscopic properties of P700, leading us to conclude that these histidines are most likely the axial ligands to the P700 chlorophylls.	Histidine	166-176	photosystem I P700 chlorophyll a apoprotein A2	Chlamydomonas reinhardtii	62-66
9460923-4	1998	This was due to the presence of a histidine tag on the recombinant ORF19 protein preventing immune recognition of the C-terminal amino acids during immunization.	Histidine	34-43	succinyl-CoA:glutarate-CoA transferase	Homo sapiens	67-72
9395474-4	1997	Mutation of the histidine (H43Q) or aspartic acid (D45A) residues of this motif reduced the ability of Csp to stimulate the ATPase activity of mammalian Hsc70.	Histidine	16-25	heat shock protein family A (Hsp70) member 8	Homo sapiens	153-158
22358898-0	1997	Preparation of recombinant six-histidine-tagged human LECT2, a chemotactic protein to neutrophils, in Escherichia coli.	Histidine	31-40	leukocyte cell derived chemotaxin 2	Homo sapiens	54-59
22358898-2	1997	A recombinant six-histidine-tagged human LECT2, (His)(6)-LECT2, was expressed in E. coli using a pET21a(+) vector.	Histidine	18-27	leukocyte cell derived chemotaxin 2	Homo sapiens	41-46
22358898-2	1997	A recombinant six-histidine-tagged human LECT2, (His)(6)-LECT2, was expressed in E. coli using a pET21a(+) vector.	Histidine	18-27	leukocyte cell derived chemotaxin 2	Homo sapiens	57-62
9359580-2	1997	The gene product is a 271 amino acid protein that contains the conserved serine, histidine and aspartic acid residues found in serine proteases, and has the highest identity to a serine protease of unknown function from Drosophila melanogaster.	Histidine	81-90	Jonah 99Ci	Drosophila melanogaster	127-142
9342405-7	1997	An outstanding feature of Mss11p is that the protein contains regions of 33 asparagine residues interrupted by only three serine residues, and 35 glutamine residues interrupted by a single histidine residue.	Histidine	189-198	Mss11p	Saccharomyces cerevisiae S288C	26-32
9342227-3	1997	In this study, we have expressed and affinity purified recombinant dCK, using the pET 9d vector system with a histidine tag-sequence and a thrombin cleavage site fused to the N-terminus of the dCK coding sequence.	Histidine	110-119	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	67-70
9278528-2	1997	Protein kinase C (PKC) and calcium and calmodulin-dependent protein kinase type II (CaM KII) phosphorylated a recombinant his-tagged synprint site polypeptide rapidly to a stoichiometry of 3-4 mol of phosphate/mol, whereas cAMP-dependent protein kinase (PKA) and cGMP-dependent protein kinase (PKG) phosphorylated the synprint peptide more slowly to a stoichiometry of &lt;1 mol/mol.	Histidine	122-125	protein kinase C, gamma	Rattus norvegicus	0-16
9278528-2	1997	Protein kinase C (PKC) and calcium and calmodulin-dependent protein kinase type II (CaM KII) phosphorylated a recombinant his-tagged synprint site polypeptide rapidly to a stoichiometry of 3-4 mol of phosphate/mol, whereas cAMP-dependent protein kinase (PKA) and cGMP-dependent protein kinase (PKG) phosphorylated the synprint peptide more slowly to a stoichiometry of &lt;1 mol/mol.	Histidine	122-125	protein kinase C, gamma	Rattus norvegicus	18-21
9464573-6	1997	Histidine tagging of GFP-CNTF permitted ready purification by means of immobilized Ni(II) chromatography.	Histidine	0-9	ciliary neurotrophic factor	Homo sapiens	25-29
11669966-1	1997	Copper(III) complexes of Gly(2)HisGly and Aib(2)HisGly are characterized, where Gly is glycine, His is L-histidine, and Aib is alpha-aminoisobutyric acid.	Histidine	31-34	ANIB1	Homo sapiens	120-123
11669966-1	1997	Copper(III) complexes of Gly(2)HisGly and Aib(2)HisGly are characterized, where Gly is glycine, His is L-histidine, and Aib is alpha-aminoisobutyric acid.	Histidine	103-114	ANIB1	Homo sapiens	42-45
9220017-3	1997	The PTHrP encoded sequences were thereby fused at their NH2-termini to six histidine residues within the fusion protein.	Histidine	75-84	parathyroid hormone-like hormone	Rattus norvegicus	4-9
9220017-4	1997	The recombinant plasmids were transfected into E. coli cells and PTHrP synthesis was induced by addition of 1 mM isopropyl-beta-D-thiogalactopyranoside (IPTG) at 37 degrees C. The recombinant fusion proteins were purified by binding of the histidine residues to a nickel column followed by gradient elusion and dialysis.	Histidine	240-249	parathyroid hormone-like hormone	Rattus norvegicus	65-70
9189046-3	1997	A point mutation was identified in all of them at position 101 of the gene for alpha-TTP, where histidine (CAT) was replaced with glutamine (CAG).	Histidine	96-105	alpha tocopherol transfer protein	Homo sapiens	79-88
9266477-1	1997	The structure of neuromedin C, a 10-residue bombesin-like neuropeptide with the sequence Gly-Asn-His-Trp-Ala-Val-Gly-His-Leu-Met-NH2, has been investigated.	Histidine	117-120	gastrin releasing peptide	Homo sapiens	17-29
9060645-6	1997	Based on data from site-directed mutagenesis combined with zinc content determination, we propose that Cys-97, Cys-99, Cys-145, and His-149 coordinate the structural zinc in the HCV NS3 proteinase.	Histidine	132-135	KRAS proto-oncogene, GTPase	Homo sapiens	182-185
9062474-4	1997	An activating mutation of the TSH receptor gene in both the primary tumor and the lymph node metastasis was found, due to a base substitution at codon 633 (normal guanine at position 1896 replaced by cytosine CAC for GAC causing aspartic acid substitution by histidine).	Histidine	259-268	thyroid stimulating hormone receptor	Homo sapiens	30-42
9360711-4	1997	The K(app) for PIP2 was 142 +/- 11 and 156 +/- 12 microM for His.PLC delta 3 and PLC delta 3, respectively.	Histidine	61-64	phospholipase C delta 3	Homo sapiens	65-76
9242908-2	1997	These structures reveal that the B12 cofactor undergoes a major conformational change on binding to the apoenzymes of methionine synthase and methylmalonyl-coenzyme A mutase: The dimethylbenzimidazole ligand to the cobalt is displaced by a histidine residue from the protein.	Histidine	240-249	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	118-137
9242908-2	1997	These structures reveal that the B12 cofactor undergoes a major conformational change on binding to the apoenzymes of methionine synthase and methylmalonyl-coenzyme A mutase: The dimethylbenzimidazole ligand to the cobalt is displaced by a histidine residue from the protein.	Histidine	240-249	methylmalonyl-CoA mutase	Homo sapiens	142-173
9242908-6	1997	In methionine synthase, the best studied of the methyltransferases, the histidine ligand appears to be required for competent methyl transfer between methyl-tetrahydrofolate and homocysteine but dissociates for reductive reactivation of the inactive oxidized enzyme.	Histidine	72-81	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	3-22
9242908-8	1997	The best-characterized B12-dependent mutases that catalyze carbon skeleton rearrangement, for which methylmalonyl-coenzyme A mutase is the prototype, also bind cobalamin cofactors with histidine as the cobalt ligand, although other cobalamin-dependent mutases do not appear to utilize histidine ligation.	Histidine	185-194	methylmalonyl-CoA mutase	Homo sapiens	100-131
9242908-8	1997	The best-characterized B12-dependent mutases that catalyze carbon skeleton rearrangement, for which methylmalonyl-coenzyme A mutase is the prototype, also bind cobalamin cofactors with histidine as the cobalt ligand, although other cobalamin-dependent mutases do not appear to utilize histidine ligation.	Histidine	285-294	methylmalonyl-CoA mutase	Homo sapiens	100-131
8975710-4	1996	The predicted human DYRK and murine Dyrk proteins both contain a nuclear targeting signal sequence, a protein kinase domain, a putative leucine zipper motif, and a highly conserved 13-consecutive-histidine repeat.	Histidine	196-205	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a	Mus musculus	36-40
8972866-2	1996	The histidine-tagged HNF1/1-281 DNA binding domain and nuclear extract from rat liver were used.	Histidine	4-13	HNF1 homeobox A	Rattus norvegicus	21-25
9007276-10	1996	This difference is discussed on basis of modeling, taking in view the difference at position 13, with Arg in pLT and His in hLT.	Histidine	117-120	Leucine transport, high	Homo sapiens	124-127
8885841-3	1996	We have generated mutants of cytochrome b562 in which the histidine ligand to the heme iron (His102) has been replaced by a methionine.	Histidine	58-67	mitochondrially encoded cytochrome b	Homo sapiens	29-41
8900174-9	1996	Three photo-labeled residues, His-244 (alpha3 helix), Met-308, and Arg-310 (alpha4/beta6 interface), were specifically identified as photoinsertion sites.	Histidine	30-33	immunoglobulin binding protein 1	Homo sapiens	76-88
3813569-3	1987	Denatured PTH showed only one histidine C-2 peak with a pKa of 6.7.	Histidine	30-39	parathyroid hormone	Bos taurus	10-13
2877746-4	1986	In addition to the prd-specific his-pro repeat, some of the 12 genes contain M-repeats and two new types of homeo boxes not detectable by hybridization with the two known classes of homeo boxes.	Histidine	32-35	paired	Drosophila melanogaster	19-22
8874200-6	1996	Sequence analysis of the Fc gamma RIIIA gene, encoding CD16 on NK cells and macrophages, showed a T to A nucleotide substitution at position 230 on both alleles, predicting a leucine (L) to histidine (H) amino acid change position 48 in the first extracellular lg-like domain of Fc gamma RIIIa, which contains the Leu11c/B73.1 epitope.	Histidine	190-199	Fc gamma receptor IIIa	Homo sapiens	25-39
8874200-6	1996	Sequence analysis of the Fc gamma RIIIA gene, encoding CD16 on NK cells and macrophages, showed a T to A nucleotide substitution at position 230 on both alleles, predicting a leucine (L) to histidine (H) amino acid change position 48 in the first extracellular lg-like domain of Fc gamma RIIIa, which contains the Leu11c/B73.1 epitope.	Histidine	190-199	Fc gamma receptor IIIa	Homo sapiens	55-59
3707913-8	1986	Although the crystal structure of carp parvalbumin indicates that His-26 is exposed to solvent [Kretsinger, R. H., &amp; Nockolds, C. E. (1973) J. Biol.	Histidine	66-69	parvalbumin	Rattus norvegicus	39-50
3707913-11	1986	In contrast, His-48 in rat parvalbumin and His-106 in pike III parvalbumin show dramatic photo-CIDNP enhancements of their C2H, C5H, and beta-CH2 1H NMR resonances.	Histidine	13-16	parvalbumin	Rattus norvegicus	27-38
8848048-5	1996	Binding occurs between the first cysteine-histidine-rich region of p300/CBP and the carboxy-terminal segment of Stat2, a domain essential for ISGF3 function.	Histidine	42-51	signal transducer and activator of transcription 2	Homo sapiens	112-117
8848048-5	1996	Binding occurs between the first cysteine-histidine-rich region of p300/CBP and the carboxy-terminal segment of Stat2, a domain essential for ISGF3 function.	Histidine	42-51	signal transducer and activator of transcription 2	Homo sapiens	142-147
3707913-11	1986	In contrast, His-48 in rat parvalbumin and His-106 in pike III parvalbumin show dramatic photo-CIDNP enhancements of their C2H, C5H, and beta-CH2 1H NMR resonances.	Histidine	13-16	parvalbumin	Rattus norvegicus	63-74
3707913-11	1986	In contrast, His-48 in rat parvalbumin and His-106 in pike III parvalbumin show dramatic photo-CIDNP enhancements of their C2H, C5H, and beta-CH2 1H NMR resonances.	Histidine	43-46	parvalbumin	Rattus norvegicus	63-74
3080348-4	1986	By correlating the size of the peptide fragments released by these enzymes with the known sequence of aldolase, evidence has been provided that cleavage of His-359 and/or Tyr-361 lead to the loss of FBP activity, while further cleavage of up to six amino acids begin to affect activity against F1P, as well.	Histidine	156-159	fructose-bisphosphatase 1	Homo sapiens	199-202
8781408-9	1996	However, the binding of BCR/abl to p85 SH2 domains was abolished in cells expressing mutant, temperature-sensitive (ts) p210 BCR/abl in which the tyrosine in the YXXM motif of p210 BCR/abl was replaced by histidine.	Histidine	205-214	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	28-31
8781408-9	1996	However, the binding of BCR/abl to p85 SH2 domains was abolished in cells expressing mutant, temperature-sensitive (ts) p210 BCR/abl in which the tyrosine in the YXXM motif of p210 BCR/abl was replaced by histidine.	Histidine	205-214	envoplakin	Mus musculus	120-124
8781408-9	1996	However, the binding of BCR/abl to p85 SH2 domains was abolished in cells expressing mutant, temperature-sensitive (ts) p210 BCR/abl in which the tyrosine in the YXXM motif of p210 BCR/abl was replaced by histidine.	Histidine	205-214	envoplakin	Mus musculus	176-180
2887178-1	1985	Catabolism of histidine was investigated in 24 patients with different speech and language disorders and with significantly low histidase activity in stratum corneum.	Histidine	14-23	histidine ammonia-lyase	Homo sapiens	128-137
8702754-3	1996	Tris/Tricine/SDS-polyacrylamide gel electrophoresis and immunoblot analyses of histidine-tagged recombinant placentin indicate that it is composed of two peptide chains of apparent molecular masses of 4 and 13 kDa.	Histidine	79-88	insulin like 4	Homo sapiens	108-117
8967341-2	1996	We performed in-gel kinase assays with His-c-jun-(1-79), which contains the amino-terminal activation domain of c-jun and a mutant His-c-jun in which Ser-63 and Ser-73 of His-c-jun were mutated to Ala as the substrates.	Histidine	39-42	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	43-48
2887178-3	1985	Biochemical investigation of these patients after loading with L-histidine led to the conclusions that low histidase activity in stratum corneum was connected with: disturbances in folic acid metabolism (2 cases); "atypical histidinemia" (1 case); heterozygotes of histidinemia (2 cases); normal liver histidine metabolism but abnormal in other tissues (18 cases); previously unknown error of histidine metabolism (1 case).	Histidine	63-74	histidine ammonia-lyase	Homo sapiens	107-116
8967341-3	1996	JNK1 (p45) and JNK2 (p54) isoforms phosphorylated His-c-jun in mesangial cells.	Histidine	50-53	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	54-59
2887178-3	1985	Biochemical investigation of these patients after loading with L-histidine led to the conclusions that low histidase activity in stratum corneum was connected with: disturbances in folic acid metabolism (2 cases); "atypical histidinemia" (1 case); heterozygotes of histidinemia (2 cases); normal liver histidine metabolism but abnormal in other tissues (18 cases); previously unknown error of histidine metabolism (1 case).	Histidine	65-74	histidine ammonia-lyase	Homo sapiens	107-116
2887178-3	1985	Biochemical investigation of these patients after loading with L-histidine led to the conclusions that low histidase activity in stratum corneum was connected with: disturbances in folic acid metabolism (2 cases); "atypical histidinemia" (1 case); heterozygotes of histidinemia (2 cases); normal liver histidine metabolism but abnormal in other tissues (18 cases); previously unknown error of histidine metabolism (1 case).	Histidine	224-233	histidine ammonia-lyase	Homo sapiens	107-116
3156581-4	1985	Histidine residues are the primary target for the sensitized photo-oxidation that inactivates lipoamide dehydrogenase and alcohol dehydrogenase.	Histidine	0-9	aldo-keto reductase family 1 member A1	Homo sapiens	122-143
8919915-7	1996	Three histidine-rich motifs (HX3H, HX2HH and HX2HH) were found in the A. thaliana ORF which are also present in the yeast ERG 3 gene.	Histidine	6-15	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	122-127
8652590-3	1996	The lower axial ligand to the cobalt in free methylcobalamin is the dimethylbenzimidazole nucleotide substituent of the corrin ring; when methylcobalamin binds to methionine synthase, the ligand is replaced by histidine 759, which in turn is linked by hydrogen bonds to aspartate 757 and thence to serine 810.	Histidine	210-219	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	163-182
3925401-1	1985	Chemical modification studies on homogeneous bovine lens aldose reductase using diethylpyrocarbonate, phenylglyoxal, butanedione, N-ethylmaleimide and p-chloromercuribenzoate indicate that histidine and arginine residues located at or near the nucleotide binding site may be important in binding or orientation of the NADPH, and that NADPH oxidation with glucose requires protein thiol.	Histidine	189-198	aldose reductase	Bos taurus	57-73
6525172-1	1984	Chemical modification of amino acid residues with phenylglyoxal, N-ethylmaleimide and diethyl pyrocarbonate indicated that at least one residue each of arginine, cysteine and histidine were essential for the activity of sheep liver serine hydroxymethyltransferase.	Histidine	175-184	serine hydroxymethyltransferase, cytosolic	Ovis aries	232-263
8593783-6	1996	Mutations in the human IGF-I receptor were either replacement of tyrosines 1250 and 1251 with phenylalanine and histidine (yyFH), respectively, or replacement of the conserved distal tyrosine (position 1316) with phenylalanine (yCF).	Histidine	112-121	insulin like growth factor 1 receptor	Homo sapiens	23-37
6470009-1	1984	Two different methods were used to determine the number of Bohr protons released upon oxygenation of human hemoglobin (Hb A) and Hb A lacking beta 146 His (des-His Hb A) at the pH ranging from pH 5.0 to 9.0 in the presence of 0.1 M Cl- at 25 degrees C. One is the direct differential titration method, the other is based on the measurement of oxygen affinity as a function of pH.	Histidine	151-154	sodium voltage-gated channel alpha subunit 2	Homo sapiens	129-133
24203237-0	1996	Use of combined mass spectrometry methods for the characterization of a new variant of human hemoglobin: The double mutant hemoglobin villeparisis beta77(EF1) His   Tyr, beta 80 (EF4) Asn   Ser.	Histidine	159-162	GTP binding elongation factor GUF1	Homo sapiens	179-182
6470009-1	1984	Two different methods were used to determine the number of Bohr protons released upon oxygenation of human hemoglobin (Hb A) and Hb A lacking beta 146 His (des-His Hb A) at the pH ranging from pH 5.0 to 9.0 in the presence of 0.1 M Cl- at 25 degrees C. One is the direct differential titration method, the other is based on the measurement of oxygen affinity as a function of pH.	Histidine	151-154	sodium voltage-gated channel alpha subunit 2	Homo sapiens	129-133
6470009-8	1984	105, 353-360), it became evident that almost all (about 92%) of the alkaline Bohr protons released upon oxygenation of Hb A in the presence of 0.1 M Cl- could be accounted for by the protons from these 2 residues, although the involvement of other histidine residues could not be denied.	Histidine	248-257	sodium voltage-gated channel alpha subunit 2	Homo sapiens	119-123
6470009-9	1984	About half the acid Bohr protons from Hb A, which corresponds to the higher pH part (above pH 5.0) of the acid Bohr effect, could be explained by the involvement of beta 143 His residue.	Histidine	174-177	sodium voltage-gated channel alpha subunit 2	Homo sapiens	38-42
16663647-3	1984	Comparison of trichloroacetic acid (TCA)-soluble products derived from the hydrolysis of hemoglobin showed that carboxyterminal amino acids (histidine, arginine, and tyrosine), are released when extracts from wheat and barley endosperms are used.	Histidine	141-150	non-symbiotic hemoglobin	Zea mays	89-99
8532526-1	1995	The human DNA repair protein XRCC1 was overexpressed as a histidine-tagged polypeptide (denoted XRCC1-His) in Escherichia coli and purified in milligram quantities by affinity chromatography.	Histidine	58-67	X-ray repair cross complementing 1	Homo sapiens	29-34
8532526-1	1995	The human DNA repair protein XRCC1 was overexpressed as a histidine-tagged polypeptide (denoted XRCC1-His) in Escherichia coli and purified in milligram quantities by affinity chromatography.	Histidine	58-67	X-ray repair cross complementing 1	Homo sapiens	96-101
8532526-1	1995	The human DNA repair protein XRCC1 was overexpressed as a histidine-tagged polypeptide (denoted XRCC1-His) in Escherichia coli and purified in milligram quantities by affinity chromatography.	Histidine	102-105	X-ray repair cross complementing 1	Homo sapiens	29-34
8532526-1	1995	The human DNA repair protein XRCC1 was overexpressed as a histidine-tagged polypeptide (denoted XRCC1-His) in Escherichia coli and purified in milligram quantities by affinity chromatography.	Histidine	102-105	X-ray repair cross complementing 1	Homo sapiens	96-101
6626566-10	1983	Preincubation with p-bromophenacyl bromide inhibited phospholipase A2, suggesting the presence of histidine at the active site.	Histidine	98-107	phospholipase A2, group IB, pancreas	Mus musculus	53-69
7577912-1	1995	The active site of pig heart citrate synthase contains a histidine residue (H320) which interacts with the carbonyl oxygen of oxaloacetate and is implicated in substrate activation through carbonyl bond polarization, a major catalytic strategy of the enzyme.	Histidine	57-66	citrate synthase	Sus scrofa	29-45
6848456-5	1983	Both NIF polypeptides contain one cysteine and one methionine, lack isoleucine, tyrosine and phenylalanine, and are rich in histidine and proline.	Histidine	124-133	S100 calcium binding protein A9	Homo sapiens	5-8
7561101-7	1995	Sequence analysis of wild-type CEM and CEM-NKR CD44 cDNA demonstrated a G to A point mutation at position 575 in the CD44 cDNA of CEM-NKR, resulting in an arginine to histidine mutation at aa position 154.	Histidine	167-176	CD44 molecule (Indian blood group)	Homo sapiens	47-51
7561101-7	1995	Sequence analysis of wild-type CEM and CEM-NKR CD44 cDNA demonstrated a G to A point mutation at position 575 in the CD44 cDNA of CEM-NKR, resulting in an arginine to histidine mutation at aa position 154.	Histidine	167-176	CD44 molecule (Indian blood group)	Homo sapiens	117-121
6136484-7	1983	These findings point to the severe impairment of histidase and urocanase, two enzymes regulating the histidine catabolic pathway.	Histidine	101-110	histidine ammonia-lyase	Homo sapiens	49-58
8561858-1	1995	Results of the present investigation indicate that mouse gamma-nerve growth factor (gamma-NGF), which belongs to the kallikrein family of proteins, specifically cleaves the Phe-His bond of a synthetic renin substrate and exhibits rat-tonin-like activity.	Histidine	177-180	kallikrein 1-related peptidase b3	Mus musculus	57-82
8561858-1	1995	Results of the present investigation indicate that mouse gamma-nerve growth factor (gamma-NGF), which belongs to the kallikrein family of proteins, specifically cleaves the Phe-His bond of a synthetic renin substrate and exhibits rat-tonin-like activity.	Histidine	177-180	kallikrein 1-related peptidase b3	Mus musculus	84-93
6281785-1	1982	alpha-Melanocyte-stimulating hormone (alpha-melanotropin; alpha-MSH) is a linear tridecapeptide (Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2) that reversibly darkens amphibian skins by stimulating melanomsome (pigment granule) dispersion within melanophores.	Histidine	120-123	msh homeobox 1	Mus musculus	64-67
7654686-2	1995	This approach facilitated the rapid purification of native-like, histidine-cleaved GroES (HC-GroES).	Histidine	65-74	chaperonin GroES	Escherichia coli	83-88
6913406-7	1981	The modified amino acid was identified as pi - (carboxymethyl)histidine, which establishes that His-66 is at or near the AA-tRNA binding site on EF-Tu.GTP.	Histidine	96-99	eukaryotic translation elongation factor, selenocysteine-specific	Drosophila melanogaster	145-150
7757970-2	1995	We produced a recombinant MAGE-3 gene product by expression cloning of the entire reading frame in the context of a fusion protein characterized by a 10-histidine tail, allowing purification by metal chelation on a nickel Sepharose column.	Histidine	153-162	MAGE family member A3	Homo sapiens	26-32
7755634-1	1995	The human histidyl-tRNA synthetase (HRS) gene encodes an enzyme that catalyzes the esterification of histidine to its cognate tRNA as an early step in protein biosynthesis.	Histidine	101-110	histidyl-tRNA synthetase 1	Homo sapiens	10-34
7282485-13	1981	(3) HDC activity in chick stomach decreased sharply as a function of dietary histidine.	Histidine	77-86	histidine decarboxylase	Gallus gallus	4-7
6115414-12	1981	It seems possible that glucose-6-phosphate isomerase, triose phosphate isomerase and pyruvate kinase all contain a histidine and a glutamate residue at the active site.	Histidine	115-124	glucose-6-phosphate isomerase	Sus scrofa	23-52
6790399-5	1981	In a case of 5 year-old boy with clinical histidinemia, in whom serum histidine level was 12.1 mg/kl, histidase activity of stratum corneum was not detectable, FIGLU and urocanic acid in urine and urocanic acid in sweat were not detected, the half life of histidine at intravenous histidine loading test was too long to measure.	Histidine	42-51	histidine ammonia-lyase	Homo sapiens	102-111
7755634-1	1995	The human histidyl-tRNA synthetase (HRS) gene encodes an enzyme that catalyzes the esterification of histidine to its cognate tRNA as an early step in protein biosynthesis.	Histidine	101-110	histidyl-tRNA synthetase 1	Homo sapiens	36-39
6164144-1	1980	The histidine metabolism in homogenates of human tissues of nontreated benign prostatic hyperplasia has been examined by means of the determination of L-histidine ammonia lyase activity (EC 4.3.1.3;histidine alpha-deaminase, histidase) and the histidine imidazole metabolites which were separated by means of ion exchange chromatography.	Histidine	4-13	histidine ammonia-lyase	Homo sapiens	153-176
7588568-6	1995	Recombinant uPAR from E. coli (corresponding to amino acids 1-284 of human uPAR) was expressed with an N-terminal histidine-tag insertion and purified by nickel chelate affinity chromatography.	Histidine	114-123	urokinase plasminogen activator surface receptor	Cricetulus griseus	12-16
7733674-8	1995	This prokaryotic expression system yields moderate amounts of unmodified recombinant His-cPLA2 and is advantageous for rapid production of protein and mutational analyses.	Histidine	85-88	phospholipase A2 group IVA	Homo sapiens	89-94
7713895-0	1995	Molecular and biochemical evidence for the involvement of the Asp-333-His-523 pair in the catalytic mechanism of soluble epoxide hydrolase.	Histidine	70-73	epoxide hydrolase 2, cytoplasmic	Mus musculus	113-138
393248-0	1979	The exchange of histidine C-2 protons in superoxide dismutases.	Histidine	16-25	complement C2	Bos taurus	26-29
7723029-2	1995	Com contains six cysteine and five histidine residues that have the potential to form several alternative zinc-finger-like motifs.	Histidine	35-44	Com family DNA-binding transcriptional regulator	Escherichia phage Mu	0-3
393248-2	1979	The rates of exchange of the C-2 protons of histidine residues in copper-zinc superoxide dismutase are substantially decreased by metal ion binding.	Histidine	44-53	complement C2	Bos taurus	29-32
430230-0	1979	Effect of induction of histidase on histidine metabolism in vivo.	Histidine	36-45	histidine ammonia-lyase	Homo sapiens	23-32
7753050-4	1995	Although feline CD9 appears most homologous to human CD9, it has two important features in common with bovine and murine CD9: the presence of a histidine residue at position 192 which is absent from the corresponding position (194) in human CD9; and the absence of two asparagine residues which are found at positions 51 and 52 of human CD9.	Histidine	144-153	CD9 molecule	Homo sapiens	16-19
80232-1	1978	The carbethoxylation of prostatic acid phosphatase (orthophosphoric-monoester phosphohydrolase (acid optimum), EC 3.1.3.2) was accompanied by modification of histidine residues and the inactivation of the enzyme.	Histidine	158-167	acid phosphatase 3	Homo sapiens	24-50
7706275-0	1995	Exposure of hydrophobic surfaces on the chaperonin GroEL oligomer by protonation or modification of His-401.	Histidine	100-103	heat shock protein family D (Hsp60) member 1	Homo sapiens	51-56
7706275-1	1995	Hydrophobic exposure on the chaperonin GroEL is increased 6-10-fold after the protein is treated with the His-reactive reagent diethyl pyrocarbonate (DEP), or the solution pH is lowered to 5.5.	Histidine	106-109	heat shock protein family D (Hsp60) member 1	Homo sapiens	39-44
7706275-3	1995	The pKa for the pH-induced transition is 6.6, most likely attributable to the only histidine in GroEL, His-401, located in the intermediate domain.	Histidine	83-92	heat shock protein family D (Hsp60) member 1	Homo sapiens	96-101
7706275-3	1995	The pKa for the pH-induced transition is 6.6, most likely attributable to the only histidine in GroEL, His-401, located in the intermediate domain.	Histidine	103-106	heat shock protein family D (Hsp60) member 1	Homo sapiens	96-101
680433-4	1978	The His-Purkinje (HV interval) and intraventicular (QRS interval) conduction times are prolonged (P less than 0.001), as well as the RRF of His-Purkinje system.	Histidine	140-143	mitochondrial ribosome recycling factor	Homo sapiens	133-136
7705335-4	1995	FIP-fve consists of 114 amino acid residues with an acetylated amino end, and lacks methionine, half-cystine and histidine residues.	Histidine	113-122	upstream transcription factor 2, c-fos interacting	Homo sapiens	0-3
886385-0	1977	Effect of histidine intake and hepatic histidase activity on the metabolism of histidine in vivo.	Histidine	79-88	histidine ammonia-lyase	Homo sapiens	39-48
7853501-3	1995	Using affinity-purified histidine-tagged NS1 preparations, we have shown that the specific protein-DNA interaction is of moderate affinity, being stable in 0.1 M salt but rapidly lost at higher salt concentrations.	Histidine	24-33	influenza virus NS1A binding protein	Homo sapiens	41-44
16641-1	1977	Human carbonic anhydrase B (HCAB), prepared by a new affinity chromatography procedure, was carboxymethylated exclusively at NT of its active-site histidine-200 using 90% [1-13C]bromoacetate.	Histidine	147-156	carbonic anhydrase 2	Homo sapiens	6-26
7872792-0	1995	Demonstration that histidine 25, but not 132, is the axial heme ligand in rat heme oxygenase-1.	Histidine	19-28	heme oxygenase 1	Rattus norvegicus	78-94
7875301-2	1995	TIMP-2, an inhibitory protein of 72 kDa gelatinase/type IV collagenase (MMP-2), was expressed in Escherichia coli as a fusion protein with a 34 amino acid NH2-linked tail containing six consecutive histidine residues.	Histidine	198-207	TIMP metallopeptidase inhibitor 2	Homo sapiens	0-6
265581-3	1977	The amino acid sequence analysis of tryptic peptide 17" of protein A24: (see text) showed it contains tryptic peptide 17 of histone 2A, Lys-Thr-Glu-Ser-His-His-Lys.	Histidine	152-155	immunoglobulin kappa variable 2-23 (pseudogene)	Homo sapiens	67-70
7630888-4	1995	This fusion toxin has a deduced molecular weight of 67 440 and is formed by the fusion of the first 389 amino acids of diphtheria toxin to amino acids 15-200 of mature human CNTF (Cys17--&gt;Ser), using a bridge of 34 additional amino acids including six consecutive histidine residues.	Histidine	267-276	ciliary neurotrophic factor	Homo sapiens	174-178
265581-3	1977	The amino acid sequence analysis of tryptic peptide 17" of protein A24: (see text) showed it contains tryptic peptide 17 of histone 2A, Lys-Thr-Glu-Ser-His-His-Lys.	Histidine	156-159	immunoglobulin kappa variable 2-23 (pseudogene)	Homo sapiens	67-70
7747623-3	1995	The 48-amino-acid pre-pro-peptide contains the expected hydrophobic leader sequence and the dibasic Lys-Arg sequence preceding the NH2-terminal His of the mature 49-amino-acid chicken osteocalcin, which is believed to be necessary for pro-peptide cleavage.	Histidine	144-147	bone gamma-carboxyglutamate protein	Gallus gallus	184-195
8556514-2	1994	We investigated the His-Arg (CAT/CGT) polymorphism at codon 131 of the Fc gamma receptor IIA gene, which influences ligand binding by the receptor.	Histidine	20-23	UDP glycosyltransferase 8	Homo sapiens	33-36
849244-5	1977	This can be explained by the alkylation of the epsilon-amino of lysine residue beta76, but some evidence for the alkylation of histidine in the minor band of Hbb-p is also presented.	Histidine	127-136	hemoglobin beta chain complex	Mus musculus	158-161
952947-9	1976	The amino acid compositions of the histidine and/or tyrosine containing peptides indicated a high degree of homology with bovine thrombin.	Histidine	35-44	coagulation factor II, thrombin	Bos taurus	129-137
7852964-8	1994	Two patients, both subtype D strains (D214 and D482) with false negative results in the RTDs, showed a significant amino acid substitution, i.e., substitution of a histidine residue for leucine at env position 607.	Histidine	164-173	endogenous retrovirus group K member 20	Homo sapiens	197-200
944591-14	1976	Inhibition by the active-site-histidine-modifying inhibitor, N-alpha-p-tosyl-L-arginine chloromethyl ketone, was enhanced by the addition of prothrombin fragment 2.	Histidine	30-39	coagulation factor II, thrombin	Bos taurus	141-152
7935399-7	1994	When a fragment covering that region was inserted immediately upstream of the open reading frame of HIS3, the resulting gene fusion, if introduced into a his3 yeast strain, supported growth on histidine-lacking medium.	Histidine	193-202	imidazoleglycerol-phosphate dehydratase HIS3	Saccharomyces cerevisiae S288C	100-104
7935399-7	1994	When a fragment covering that region was inserted immediately upstream of the open reading frame of HIS3, the resulting gene fusion, if introduced into a his3 yeast strain, supported growth on histidine-lacking medium.	Histidine	193-202	imidazoleglycerol-phosphate dehydratase HIS3	Saccharomyces cerevisiae S288C	154-158
8091686-5	1994	Comparative sequence analysis showed that tsG VP6 contains two mutant amino acids, i.e., Thr-10 and His-13, and therefore one or both of these mutations are responsible for the ts phenotype of the mutant VP6.	Histidine	100-103	twisted gastrulation BMP signaling modulator 1	Homo sapiens	42-45
1201380-4	1975	3 Both the tryptophan and histidine residues seemed to be essential for bombesin-like activity.	Histidine	26-35	gastrin releasing peptide	Homo sapiens	72-80
8091686-8	1994	While influencing intracellular accumulation, the Thr-10--&gt;Ser and His-13--&gt;Asp mutations in tsG VP6 are probably not directly involved in the interaction of VP6 with VP2, as VP6 deletion mutants lacking residues 10 and 13 retain the ability to bind VP2 in vitro.	Histidine	70-73	twisted gastrulation BMP signaling modulator 1	Homo sapiens	99-102
238843-6	1975	The correct continuities for the titration curves of the histidine H-2 proton resonances have been confirmed by selective deuteration of the H-2 protons.	Histidine	57-66	relaxin 2	Homo sapiens	67-70
8022819-4	1994	PLC-gamma 1 with defective enzymatic activity was synthesized by substituting phenylalanine for histidine within the PLC-gamma 1 catalytic domain at amino acids 335 and 380, and mutant enzymes were expressed using a vaccinia expression system.	Histidine	96-105	phospholipase C, gamma 1	Mus musculus	0-11
238843-6	1975	The correct continuities for the titration curves of the histidine H-2 proton resonances have been confirmed by selective deuteration of the H-2 protons.	Histidine	57-66	relaxin 2	Homo sapiens	141-144
238843-7	1975	Titration curves for the H-2 proton resonances of histidine-12 and histidine-119 of methylated RNase-A show deviations from the titration curves for the native enzyme, indicating some alteration of the active-site conformation.	Histidine	50-59	relaxin 2	Homo sapiens	25-28
8037675-3	1994	Ni2+ binds to a site in the N-terminal region of the protein which is partially blocked by the presence of a propeptide as in proalbumin (proAlb) Varese (Arg-2--&gt;His), proAlb Christchurch (Arg-1--&gt;Gln) and proAlb Blenheim (Asp1--&gt;Val) and by the presence of only an extra Arg residue (Arg-1) as in Arg-Alb and albumin (Alb) Redhill.	Histidine	165-168	arginase 2	Homo sapiens	154-159
238843-7	1975	Titration curves for the H-2 proton resonances of histidine-12 and histidine-119 of methylated RNase-A show deviations from the titration curves for the native enzyme, indicating some alteration of the active-site conformation.	Histidine	67-76	relaxin 2	Homo sapiens	25-28
238843-8	1975	In the presence of phosphate, titration curves for the H-2 proton resonances of histidine-12 and histidine-119 of methylated RNase-A indicate binding of phosphate at the active site, but these curves continue to show deviations from the titration behaviour of native RNase-A.	Histidine	80-89	relaxin 2	Homo sapiens	55-58
8204623-7	1994	Evidence reported here, gathered from 31 replacement analogs, supports the idea that in the absence of the requisite carboxyl group at position 9, histidine utilizes Asp21 or Asp15 as a compensatory site.	Histidine	147-156	beta-secretase 2	Homo sapiens	166-171
8175672-1	1994	The metalloendopeptidase EC 3.4.24.15 is believed to degrade gonadotropin-releasing hormone (GnRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2) by cleavage at the Tyr5-Gly6 bond.	Histidine	105-108	thimet oligopeptidase 1	Rattus norvegicus	4-24
1168484-8	1975	It is suggested that, in addition to reaction with tyrosine, there is a reaction of N-butyrylimidazole with either the histidine and/or serine residue at the active site of thrombin resulting in a derivative unstable under esterase assay conditions such as that described for the reaciton of N-acetylimidazole with trypsin (L. L. Houston and K. A. Walsh (1970), Biochemistry 9, 156).	Histidine	119-128	coagulation factor II, thrombin	Bos taurus	173-181
8120011-5	1994	Comparison of subtilisin peptide maps of active and inactivated enzymes showed a difference in one histidine-containing peptide, the sequence of which is YNTPH277GVAN for propanediol oxidoreductase and YNLPH277GV for alcohol dehydrogenase II.	Histidine	99-108	oxidoreductase	Escherichia coli	183-197
1140885-3	1975	These peptides prepared by the stepwise procedure, are: Boc-Phe-Lys(Z)-Gln-Thr(Bzl)-Ser(Bzl)-Lys(Z)-Phe-OMe and Boc-Asp(OBzl)-Asn-Ser(Bzl)-His(Dnp)-Asn(OBzl)-Asp(OBzl)-Ala-Leu-OBzl.	Histidine	139-142	BOC cell adhesion associated, oncogene regulated	Homo sapiens	56-59
8307012-2	1994	A coagulation factor Xa (FXa)-sensitive cleavage site was introduced to remove the N-terminal histidine tag.	Histidine	94-103	coagulation factor X	Homo sapiens	14-23
8307012-2	1994	A coagulation factor Xa (FXa)-sensitive cleavage site was introduced to remove the N-terminal histidine tag.	Histidine	94-103	coagulation factor X	Homo sapiens	25-28
1140885-3	1975	These peptides prepared by the stepwise procedure, are: Boc-Phe-Lys(Z)-Gln-Thr(Bzl)-Ser(Bzl)-Lys(Z)-Phe-OMe and Boc-Asp(OBzl)-Asn-Ser(Bzl)-His(Dnp)-Asn(OBzl)-Asp(OBzl)-Ala-Leu-OBzl.	Histidine	139-142	BOC cell adhesion associated, oncogene regulated	Homo sapiens	112-115
24419545-5	1974	As well as lysine, the content of other amino acids, such as aspartic acid, arginine, glycine, threonine, valine and histidine are also, in general, increased by the presence of the o 2 gene in recessive homozygous condition.The results obtained have shown that a number of correlation coefficients between the protein quality traits and yield components related to kernel characteristics are negative and significant, especially in the presence of the o 2 gene in recessive homozygous condition.	Histidine	117-126	regulatory protein opaque-2	Zea mays	182-185
8276823-2	1994	Two residues are known to play important catalytic roles in fatty acyl-thioester hydrolase, thioesterase II: Ser-101, the site of a covalent acyl-enzyme intermediate, and His-237 which is within hydrogen bonding distance of Ser-101 and facilitates catalysis by increasing the nucleophilicity of this residue.	Histidine	171-174	acyl-CoA thioesterase 8	Homo sapiens	92-107
8276829-2	1994	We report properties of five active site mutants of Escherichia coli citrate synthase, in which histidine 264, aspartate 362, and phenylalanine 383 were replaced by alanines, and arginines 387 and 407 by leucines.	Histidine	96-105	citrate synthase	Sus scrofa	69-85
8276829-5	1994	The mutations of histidine 264 and aspartate 362 affect steady-state kinetics as would be anticipated from current models for citrate synthase catalysis, and resemble mutations of these residues, in pig heart and E. coli enzyme, reported by others.	Histidine	17-26	citrate synthase	Sus scrofa	126-142
8264637-4	1994	Affinity chromatography of extract from EM9 cells transfected with pcD2EHX resulted in the copurification of histidine-tagged XRCC1 and DNA ligase III activity.	Histidine	109-118	X-ray repair cross complementing 1	Homo sapiens	126-131
8264637-6	1994	The copurification of DNA ligase III activity with histidine-tagged XRCC1 suggests that the two proteins are present in the cell as a complex.	Histidine	51-60	X-ray repair cross complementing 1	Homo sapiens	68-73
4343380-0	1972	The histidines in liver alcohol dehydrogenase.	Histidine	4-14	aldo-keto reductase family 1 member A1	Homo sapiens	24-45
5562834-0	1971	On the probable involvement of a histidine residue in the active site of pancreatic lipase.	Histidine	33-42	pancreatic lipase	Homo sapiens	73-90
8297136-2	1993	For this purpose a new assay system employing a histidine-tag method of transient expression and rapid purification of recombinant c-Jun, in conjunction with "southwestern" blotting and in situ phosphatase treatment, was developed.	Histidine	48-57	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	131-136
8216277-3	1993	Upon the modification of about 5 of the total 22 histidine residues in the SecA molecule, both the abolition of its translocation ATPase activity and the enhancement of its SecA-ATPase activity occurred.	Histidine	49-58	ATPase	Escherichia coli	130-136
5460202-0	1970	Two haemoglobins Q, alpha-74 (EF3) and alpha-75 (EF4) aspartic acid to histidine.	Histidine	71-80	GTP binding elongation factor GUF1	Homo sapiens	49-52
8216277-3	1993	Upon the modification of about 5 of the total 22 histidine residues in the SecA molecule, both the abolition of its translocation ATPase activity and the enhancement of its SecA-ATPase activity occurred.	Histidine	49-58	ATPase	Escherichia coli	173-184
8216277-6	1993	Taken together, these results indicate that histidine residues susceptible to diethylpyrocarbonate are essential for the translocation ATPase, but not directly involved in the binding of ATP, proOmpA and membranes.	Histidine	44-53	ATPase	Escherichia coli	135-141
8369304-0	1993	Active site labeling of the Yersinia protein tyrosine phosphatase: the determination of the pKa of the active site cysteine and the function of the conserved histidine 402.	Histidine	158-167	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	37-65
33965786-4	2021	A C-terminal histidine-tagged version of zebrafish Prss 59.1 was constructed.	Histidine	13-22	serine protease 59, tandem duplicate 1	Danio rerio	51-60
8228729-0	1993	Influence of endogenous cholinergic tone and alpha-adrenergic pathways on growth hormone responses to His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 in the dog.	Histidine	102-105	somatotropin	Canis lupus familiaris	74-88
7686870-4	1993	The secreted re-NS1 was tagged with six His residues at the C terminus and purified simply by native Ni(2+)-nitrilotriacetic acid (Ni(2+)-NTA) affinity column chromatography.	Histidine	40-43	polyglutamine binding protein 1	Homo sapiens	13-19
33888855-6	2021	Moreover, we successfully synthesized films in vitro by crosslinking a 45% His-rich CP (BmorCPR152) with laccase2 using N-acetyl- dopamine or N-beta-alanyl-dopamine as the substrate.	Histidine	75-78	laccase 2	Bombyx mori	105-113
7688509-1	1993	An anti-peptide antibody was raised against the sequence Thr-Gly-Ala-Leu-Phe-Lys-His-Ser-Glu-Asn-Tyr-Lys which occurs at positions 283-294 in the rat cytochrome P450 enzyme CYP1A2.	Histidine	81-84	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	173-179
33529484-4	2021	Molecular docking and molecular dynamics simulations suggest that interactions with Glu 39, Glu 78, Arg 111, Pro 137, Asp 251 and His 252 are an important factor for inhibitors affinity toward the DNase I.	Histidine	130-133	deoxyribonuclease 1	Homo sapiens	197-204
8471773-4	1993	From these 43 samples, we have identified five different types of nucleotide substitutions in the G6PD gene: at cDNA 1388 from G to A (Arg to His); at cDNA 1376 from G to T (Arg to Leu); at cDNA 1024 from C to T (Leu to Phe); at cDNA 392 from G to T (Gly to Val); at cDNA 95 from A to G (His to Arg).	Histidine	142-145	glucose-6-phosphate dehydrogenase	Homo sapiens	98-102
8471773-4	1993	From these 43 samples, we have identified five different types of nucleotide substitutions in the G6PD gene: at cDNA 1388 from G to A (Arg to His); at cDNA 1376 from G to T (Arg to Leu); at cDNA 1024 from C to T (Leu to Phe); at cDNA 392 from G to T (Gly to Val); at cDNA 95 from A to G (His to Arg).	Histidine	288-291	glucose-6-phosphate dehydrogenase	Homo sapiens	98-102
33563959-6	2021	Our results establish METTL9-mediated 1MH as a pervasive protein modification, thus setting the stage for further functional studies on protein histidine methylation.	Histidine	144-153	methyltransferase like 9	Homo sapiens	22-28
8481357-5	1993	Affected individuals have a single base substitution in exon 8 of CYP11B1, codon 448, from CGC (arginine) to CAC (histidine).	Histidine	114-123	cytochrome P450 family 11 subfamily B member 1	Homo sapiens	66-73
8096060-4	1993	Two N-terminal erb A amino acids in particular, histidine 12 and cysteine 32, contribute to this phenomenon, acting in conjunction with amino acids in the zinc finger domain.	Histidine	48-57	thyroid hormone receptor alpha	Homo sapiens	15-20
8384830-6	1993	Comparison with sequences of other cytochromes c indicated the closest similarity to cytochrome c from snapping turtle (Chelydra serpentina) with substitutions at five positions corresponding to residues 32 (His--&gt;Asn), 44 (Glu--&gt;Pro), 89 (Ala--&gt;Pro), 100 (Asp--&gt;Glu), and 104 (Lys--&gt;Asn), respectively.	Histidine	208-211	cytochrome c	Alligator mississippiensis	85-97
33197826-0	2021	The N-terminal domain of Helicobacter pylori"s Hpn protein: The role of multiple histidine residues.	Histidine	81-90	hepsin	Homo sapiens	47-50
8486232-7	1993	These findings suggest that the basic amino acid at position 13, which is present only on the DR2 and DR4 B1 molecules (Arg on DR2 and His on DR4), may contribute to the susceptibility to autoimmune hepatitis of Japanese.	Histidine	135-138	major histocompatibility complex, class II, DR beta 4	Homo sapiens	102-105
8486232-7	1993	These findings suggest that the basic amino acid at position 13, which is present only on the DR2 and DR4 B1 molecules (Arg on DR2 and His on DR4), may contribute to the susceptibility to autoimmune hepatitis of Japanese.	Histidine	135-138	major histocompatibility complex, class II, DR beta 4	Homo sapiens	142-145
33197826-3	2021	Hpn is a protein of 60 amino acids, 47% of which are histidines, expressed by H. pylori and avid for nickel, characterized by the presence of an ATCUN (Amino Terminal Cu(II)- and Ni(II)-binding) motif and by two further histidine residues which can act as additional metal anchoring sites.	Histidine	53-63	hepsin	Homo sapiens	0-3
33197826-3	2021	Hpn is a protein of 60 amino acids, 47% of which are histidines, expressed by H. pylori and avid for nickel, characterized by the presence of an ATCUN (Amino Terminal Cu(II)- and Ni(II)-binding) motif and by two further histidine residues which can act as additional metal anchoring sites.	Histidine	53-62	hepsin	Homo sapiens	0-3
32780163-7	2020	We show that TAT1 suppression occurs through replenishment of the GTP pool in a process requiring the histidine biosynthesis pathway.	Histidine	102-111	amino acid transporter TAT1	Saccharomyces cerevisiae S288C	13-17
8428989-0	1993	Inactivation of the recA protein by mutation of histidine 97 or lysine 248 at the subunit interface.	Histidine	48-57	RAD51 recombinase	Homo sapiens	20-24
8428989-5	1993	To account for these results, we propose that the mutation of either histidine 97 or lysine 248 alters subunit interactions between recA monomers and that this leads to the loss of cooperative single-stranded DNA binding and DNA pairing activities.	Histidine	69-78	RAD51 recombinase	Homo sapiens	132-136
8428989-6	1993	This proposal is consistent with the recently determined x-ray structure of the recA protein, which shows that although histidine 97 and lysine 248 are distant from one another in the monomer structure, these two residues are on the opposing complementary faces of the recA subunit and pack against each other at the interface between adjacent recA monomers in the helical filament (Story, R. M., Weber, I. T., and Steitz, T. A.	Histidine	120-129	RAD51 recombinase	Homo sapiens	80-84
8419368-1	1993	Human liver alcohol dehydrogenase isoenzymes beta 1 beta 1 and beta 2 beta 2, in which position 47 in the coenzyme binding domain is an arginine or histidine, respectively, differ remarkably in steady-state kinetics.	Histidine	148-157	aldo-keto reductase family 1 member A1	Homo sapiens	12-33
32199697-5	2020	RESULTS: The liver expression levels of APOA1bp were associated with lower cIMT and leukocyte counts, a better plasma lipid profile and higher circulating levels of metabolites associated with lower risk of atherosclerosis (glycine, histidine and asparagine).	Histidine	233-242	NAD(P)HX epimerase	Homo sapiens	40-47
1361949-3	1992	Their mutual repulsion is unfavourable and zinc co-ordination to B10 histidine is necessary to stabilize the well known zinc-containing hexamers.	Histidine	69-78	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	65-68
32888909-8	2020	Noteworthy, most modifications were observed at Lys and His residues located at A-site (K73, K87, K88), L-site (H26, H33, and K27) membrane binding sites.	Histidine	56-59	keratin 73	Homo sapiens	88-91
1292009-8	1992	These mutations may affect tyrosinase activity by either altering the position of the alpha helical domains and thus preventing proper copper binding to the histidine ligands, or affecting a catalytic or substrate binding site located between the two alpha helical domains.	Histidine	157-166	tyrosinase	Homo sapiens	27-37
32982370-5	2020	The catalytic mechanism of sPLA2 is initiated by a histidine/aspartic acid/calcium complex within the active site.	Histidine	51-60	phospholipase A2 group IIA	Homo sapiens	27-32
1527531-1	1992	The effect of replacement of the highly conserved Lys45 residue in pig myoglobin (Mb) with His, Ser, Glu, and Arg has been investigated.	Histidine	91-94	myoglobin	Sus scrofa	71-80
32576658-5	2020	The catalytic domain displayed a polypeptide fold similar overall to those of other members in the DNA cross-link repair gene SNM1 family and in mRNA 3"-end-processing endonuclease CPSF-73, containing metallo-beta-lactamase and beta-CASP domains and a cluster of conserved histidine and aspartate residues capable of binding two metal atoms in the catalytic site.	Histidine	273-282	cleavage and polyadenylation specificity factor 3	Mus musculus	145-188
32823853-8	2020	Postprandial AA histidine (p < 0.001), leucine (p < 0.001), and tyrosine (p < 0.001) were higher in CGMP-AA2 than CGMP-AA1, and leucine (p < 0.001), threonine (p < 0.001), and tyrosine (p = 0.003) higher in GCMP-AA2 than Phe-free AA.	Histidine	16-25	AA2	Homo sapiens	105-108
1354193-9	1992	These findings suggest that the basic amino acid at position 13, which is present only on the DR2 and DR4 B1 molecules (Arg on DR2 and His on DR4), contributes to the susceptibility to autoimmune hepatitis among the Japanese.	Histidine	135-138	major histocompatibility complex, class II, DR beta 4	Homo sapiens	102-105
1354193-9	1992	These findings suggest that the basic amino acid at position 13, which is present only on the DR2 and DR4 B1 molecules (Arg on DR2 and His on DR4), contributes to the susceptibility to autoimmune hepatitis among the Japanese.	Histidine	135-138	major histocompatibility complex, class II, DR beta 4	Homo sapiens	142-145
32333447-1	2020	Mutations in histidyl-tRNA synthetase (HARS1), an enzyme that charges tRNA with the amino acid histidine in the cytoplasm, have only been associated to date with autosomal recessive Usher syndrome type III and autosomal dominant Charcot-Marie-Tooth disease type 2W.	Histidine	95-104	histidyl-tRNA synthetase 1	Homo sapiens	13-37
1331770-4	1992	At low ionic strength (I = 0-0.1) the pH dependence curve was found to have a sigmoid shape with pKeff approximately 5.7, implying the effect of ionization of His-119(GH1) at the "active site" of myoglobin on the kinetics of the process.	Histidine	159-162	somatotropin	Sus scrofa	167-170
1331770-7	1992	It is greater at pH less than or equal to 6 and smaller at pH 7.5, which is due to deprotonation of His(GH1).	Histidine	100-103	somatotropin	Sus scrofa	104-107
1331770-10	1992	This suggests that His(GH1) is directly involved in the mechanism of electron transfer from Mb to Cyt c. The data obtained are compared with earlier data on the effect of pH, ionic strength and zinc ions on the reaction between MbO2 from sperm whale and Cyt c. To explain the higher efficiency of pig MbO2 as electron donor, the electrostatic and steric properties of both myoglobins have been analyzed.	Histidine	19-22	somatotropin	Sus scrofa	23-26
32145391-7	2020	We compared cAMP response induced by histidine tagged CCL7 and native CCL7 and found that modification of the N-terminus of CCL7 compromises its functionality.	Histidine	37-46	C-C motif chemokine ligand 7	Homo sapiens	54-58
1639922-5	1992	The synthetic peptides represented 1-3 multiple repeat units of the 5-residue sequence (Gly-His-His-Pro-His) found in the C-terminal of HRG.	Histidine	92-95	histidine rich glycoprotein	Homo sapiens	136-139
1639922-5	1992	The synthetic peptides represented 1-3 multiple repeat units of the 5-residue sequence (Gly-His-His-Pro-His) found in the C-terminal of HRG.	Histidine	96-99	histidine rich glycoprotein	Homo sapiens	136-139
1639922-5	1992	The synthetic peptides represented 1-3 multiple repeat units of the 5-residue sequence (Gly-His-His-Pro-His) found in the C-terminal of HRG.	Histidine	96-99	histidine rich glycoprotein	Homo sapiens	136-139
32359429-4	2020	Analysis of the naked mole-rat genome revealed, uniquely among mammals, a histidine point variation in the neuronal potassium-chloride cotransporter 2 (KCC2).	Histidine	74-83	solute carrier family 12 member 5	Homo sapiens	152-156
1561009-1	1992	Histidine-rich glycoprotein (HRG) is a 74-kD glycoprotein, originally discovered in plasma, which contains an unusually large amount of histidine (13 mol%) and proline (13 mol%).	Histidine	136-145	histidine rich glycoprotein	Homo sapiens	0-27
1561009-1	1992	Histidine-rich glycoprotein (HRG) is a 74-kD glycoprotein, originally discovered in plasma, which contains an unusually large amount of histidine (13 mol%) and proline (13 mol%).	Histidine	136-145	histidine rich glycoprotein	Homo sapiens	29-32
32359429-5	2020	A histidine missense substitution mutation at this locus in the human ortholog of KCC2, found previously in patients with febrile seizures and epilepsy, has been demonstrated to diminish neuronal Cl- extrusion capacity, and thus impairs GABAergic inhibition.	Histidine	2-11	solute carrier family 12 member 5	Homo sapiens	82-86
1730643-3	1992	Two genes (EFT1 and EFT2) were isolated by screening a bacteriophage lambda yeast genomic DNA library with an oligonucleotide probe complementary to the domain of EF-2 that contains diphthamide, the unique posttranslationally modified histidine that is specifically ADP-ribosylated by diphtheria toxin.	Histidine	235-244	elongation factor 2	Saccharomyces cerevisiae S288C	11-15
32392205-5	2020	The differential specificity of ligands to BLT1 and BLT2 is explained by the replacement of histidine with tyrosine.	Histidine	92-101	leukotriene B4 receptor	Homo sapiens	43-47
32392205-6	2020	In BLT1, the histidine residue binds the 5-OH group of the ligand, while the tyrosine residue in BLT2 repels it.	Histidine	13-22	leukotriene B4 receptor	Homo sapiens	3-7
31957446-0	2020	Expression and Purification of Protease-Activated Receptor 4 (PAR4) and Analysis with Histidine Hydrogen-Deuterium Exchange.	Histidine	86-95	F2R like thrombin or trypsin receptor 3	Homo sapiens	31-60
1665866-3	1991	In a basal medium consisting of 75% DMEM, 25% Ham"s F-12, 5 nM sodium selenite, 50 microM 2-amino ethanol, and 2 mM histidine, supplemented with 5% FBS, we showed that aFGF, bFGF, and PDGF were all capable of stimulating Schwann cell growth and the stimulation was greatly potentiated by forskolin and dibutyryl-cAMP.	Histidine	116-125	fibroblast growth factor 1	Rattus norvegicus	168-172
1665895-3	1991	Furthermore actinomycin D was able to displace [125I]-His-NKA from NK2 receptor sites of the rat small intestine smooth muscle membranes.	Histidine	54-57	tachykinin receptor 2	Rattus norvegicus	67-79
31957446-7	2020	PAR4 has nine histidines that are spaced throughout the protein, allowing a global view of solvent accessible and nonaccessible regions.	Histidine	14-24	F2R like thrombin or trypsin receptor 3	Homo sapiens	0-4
31957446-9	2020	The thrombin-cleaved PAR4 exhibited a 2-fold increase (p > 0.01) in t1/2 values observed for four histidine residues (His180, His229, His240, and His380), demonstrating that these regions have decreased solvent accessibility upon thrombin treatment.	Histidine	98-107	F2R like thrombin or trypsin receptor 3	Homo sapiens	21-25
31348608-3	2020	The lysine-arginine-ornithine binding protein (LAO) is a PBP of 238 residues that binds the basic amino acids l-arginine and l-histidine with nm and mum affinity, respectively.	Histidine	125-136	phosphatidylethanolamine binding protein 1	Homo sapiens	57-60
1911719-6	1991	Nominally, DMEM contains 270 microM histidine but no copper, whereas F12 contains 135 microM histidine and 10 nM copper; addition of copper (as much as 5 microM) to DMEM or of histidine (as much as 2.16 mM) to F12 did not overcome the differences between the media in supporting LDL oxidation by endothelial cells.	Histidine	93-102	coagulation factor XII	Homo sapiens	69-72
1911719-6	1991	Nominally, DMEM contains 270 microM histidine but no copper, whereas F12 contains 135 microM histidine and 10 nM copper; addition of copper (as much as 5 microM) to DMEM or of histidine (as much as 2.16 mM) to F12 did not overcome the differences between the media in supporting LDL oxidation by endothelial cells.	Histidine	93-102	coagulation factor XII	Homo sapiens	69-72
31644276-6	2019	Also, the role of a histidine residue in the AQP4 channel was identified by alchemical transformation and umbrella sampling methods.	Histidine	20-29	aquaporin 4	Mus musculus	45-49
1711082-4	1991	An antibody-binding assay using overlapping synthetic oligopeptides showed that LAT-27 bound specifically to 10-mer peptides that contained the gp46 amino acid sequence 191-196 (Leu-Pro-His-Ser-Asn-Leu).	Histidine	186-189	serpin family H member 1	Homo sapiens	144-148
1711024-11	1991	This protein is highly homologous with the AroP (general aromatic transport) system of E. coli (59.6% identity) and to a lesser extent with the yeast permeases CAN1 (arginine), PUT4 (proline), and HIP1 (histidine) of Saccharomyces cerevisiae.	Histidine	203-212	arginine permease CAN1	Saccharomyces cerevisiae S288C	160-164
31145609-10	2019	Further electron-nuclear double resonance studies with globally 15N-labeled mCP provided hyperfine couplings from the coordinating epsilon-nitrogen atoms of the His ligands (aiso = 4.3 MHz) as well as the distal delta-nitrogen atoms (aiso = 0.25 MHz).	Histidine	161-164	CD46 antigen, complement regulatory protein	Mus musculus	76-79
1901689-5	1991	We now report the results of sequencing of the entire coding region and exon-intron junctions of TBG-Quebec, which revealed two nucleotide substitutions; one, located in exon 3, changes the normal codon 283 of TTG (leucine) to that of TTT (phenylalanine), and the other, in exon 4, results in the replacement of the normal histidine-331 (CAT) by tyrosine (TAT).	Histidine	323-332	serpin family A member 7	Homo sapiens	97-100
31375562-0	2019	Sulfur-containing histidine compounds inhibit gamma-glutamyl transpeptidase activity in human cancer cells.	Histidine	18-27	inactive glutathione hydrolase 2	Homo sapiens	46-75
1943682-2	1991	Histidase (histidine ammonia-lyase, EC 4.3.1.3) catalyzes the deamination of L-histidine to trans-urocanic acid in the liver and skin of mammals.	Histidine	77-88	histidine ammonia-lyase	Homo sapiens	0-9
1943682-2	1991	Histidase (histidine ammonia-lyase, EC 4.3.1.3) catalyzes the deamination of L-histidine to trans-urocanic acid in the liver and skin of mammals.	Histidine	77-88	histidine ammonia-lyase	Homo sapiens	11-34
1943682-3	1991	Histidase deficiency results in increased histidine and histamine in blood, and decreased urocanic acid in blood and skin.	Histidine	42-51	histidine ammonia-lyase	Homo sapiens	0-9
31220406-3	2019	Histidine-rich nona-arginine (HR9) and primary amphipathic peptide (MPG) showed the ability to transfer DNA into the cells.	Histidine	0-9	N-methylpurine DNA glycosylase	Homo sapiens	68-71
31315927-5	2019	Purified recombinant GST-TIMAP interacted directly with purified recombinant His-MLC2.	Histidine	77-80	protein phosphatase 1, regulatory subunit 16B	Mus musculus	25-30
2147282-4	1990	Site-directed mutagenesis of the His-53, Asp-77, and Ser-138 residues of NS3 that compose the proposed catalytic triad implicates this domain as a serine protease.	Histidine	33-36	KRAS proto-oncogene, GTPase	Homo sapiens	73-76
2078626-5	1990	The pK value (7.1 +/- 0.1) calculated from this model corresponds to pKn of essential His-195.	Histidine	86-89	protein kinase N1	Homo sapiens	69-72
31327794-3	2019	We evaluated the success rate of LBP/peri-LBP in patients whose treatment with His-bundle pacing failed.	Histidine	79-82	lipopolysaccharide binding protein	Homo sapiens	33-36
2249254-4	1990	The amino acid sequences deduced from the ndhH genes show conserved histidine and cysteine residues which are likely to form a metal-binding domain.	Histidine	68-77	NADH dehydrogenase 49 kDa subunit	Nicotiana tabacum	42-46
31327794-3	2019	We evaluated the success rate of LBP/peri-LBP in patients whose treatment with His-bundle pacing failed.	Histidine	79-82	perilipin 1	Homo sapiens	37-41
2271531-10	1990	Insulin mutants [B25-Asp]insulin and [B25-His]insulin display 16- and 20-fold decreases in IDE affinity versus wild-type insulin.	Histidine	42-45	insulin degrading enzyme	Homo sapiens	91-94
31327794-5	2019	CONCLUSIONS: LBP/peri-LBP is an alternative ventricular pacing method in atrioventricular block in patients with failure of His-bundle pacing.	Histidine	124-127	lipopolysaccharide binding protein	Homo sapiens	13-16
31327794-5	2019	CONCLUSIONS: LBP/peri-LBP is an alternative ventricular pacing method in atrioventricular block in patients with failure of His-bundle pacing.	Histidine	124-127	perilipin 1	Homo sapiens	17-21
31327794-5	2019	CONCLUSIONS: LBP/peri-LBP is an alternative ventricular pacing method in atrioventricular block in patients with failure of His-bundle pacing.	Histidine	124-127	lipopolysaccharide binding protein	Homo sapiens	22-25
2155655-9	1990	Based on these considerations, Glu-68 may be within the interaction sphere of cytochrome f, suggesting that cytochrome f may donate electrons to plastocyanin at either Tyr-83 or His-87.	Histidine	178-181	apocytochrome f precursor	Spinacia oleracea	78-90
31344907-7	2019	Spectroscopic data confirmed that AtLRB3 contains a histidine-ligated heme cofactor and importantly, the addition of NO to AtLRB3 yielded absorption characteristics reminiscent of canonical H-NOX proteins.	Histidine	52-61	BTB/POZ/Kelch-associated protein	Arabidopsis thaliana	34-40
2155655-9	1990	Based on these considerations, Glu-68 may be within the interaction sphere of cytochrome f, suggesting that cytochrome f may donate electrons to plastocyanin at either Tyr-83 or His-87.	Histidine	178-181	apocytochrome f precursor	Spinacia oleracea	108-120
2321910-6	1990	G6PD Montalbano is a new variant, with nearly normal properties, due to a G----A transition which causes an Arg----His amino acid replacement at position 285.	Histidine	115-118	glucose-6-phosphate dehydrogenase	Homo sapiens	0-4
31273433-2	2019	Very low islet zinc levels in Guinea pigs were thought to be driven by evolution of the INS gene that resulted in the generation of an isoform lacking a histidine at amino acid 10 in the B chain of insulin that is unable to bind zinc.	Histidine	153-162	insulin	Cavia porcellus	198-205
31537250-7	2019	The purified recombinant His-RBP was used to immunize New Zealand white rabbits.	Histidine	25-28	retinol binding protein 4	Homo sapiens	29-32
25575548-3	2015	METHODS AND RESULTS: By conducting whole exome sequencing on 1152 African Americans in the Atherosclerosis Risk in Communities (ARIC) study and focusing on loss-of-function (LoF) variants, we identified 3 novel rare LoF variants in HAL, a gene that encodes histidine ammonia-lyase in the first step of histidine catabolism.	Histidine	257-266	histidine ammonia-lyase	Homo sapiens	232-235
31142756-5	2019	SK-N-SH neuronal cells were exposed to active recombinant histidine-tagged cathepsin B (His-CATB).	Histidine	58-67	cathepsin B	Homo sapiens	75-86
34739847-8	2021	Using different PCSK9 constructs, we show that PCSK9 interacts with DACT2 through its Cys-His-rich domain (CHRD) domain.	Histidine	90-93	dishevelled binding antagonist of beta catenin 2	Homo sapiens	68-73
34948007-1	2021	Combined potentiometric titration and isothermal titration calorimetry (ITC) methods were used to study the interactions of nickel(II) ions with the N-terminal fragments and histidine-rich fragments of Hpn-like protein from two Helicobacter pylori strains (11637 and 26695).	Histidine	174-183	hepsin	Homo sapiens	202-205
31142756-5	2019	SK-N-SH neuronal cells were exposed to active recombinant histidine-tagged cathepsin B (His-CATB).	Histidine	58-67	cathepsin B	Homo sapiens	92-96
31142756-10	2019	Neurons exposed to macrophage-conditioned media differentially internalized His-CATB, dependent on the HIV replication levels.	Histidine	76-79	cathepsin B	Homo sapiens	80-84
32477731-0	2019	Direct His-bundle Pacing in a Patient with a Persistent Left Superior Vena Cava.	Histidine	7-10	carbonic anhydrase 5A	Homo sapiens	75-79
34982449-5	2021	The replacement of Histidine (His) with Asparagine (Asn) at position 1568 in the topological domain of SCN9A channel protein provides new insights into the impaired excitation and inactivation patterns of sodium channels.	Histidine	19-28	sodium voltage-gated channel alpha subunit 9	Homo sapiens	103-108
34982449-5	2021	The replacement of Histidine (His) with Asparagine (Asn) at position 1568 in the topological domain of SCN9A channel protein provides new insights into the impaired excitation and inactivation patterns of sodium channels.	Histidine	30-33	sodium voltage-gated channel alpha subunit 9	Homo sapiens	103-108
34958277-6	2021	We first established an anti-His-tag mAb, HisMab-1 (mouse IgG2b, kappa), by immunizing mice with recombinant proteins containing an N-terminal His-tag.	Histidine	29-32	immunoglobulin heavy constant gamma 2B	Mus musculus	58-63
34958277-6	2021	We first established an anti-His-tag mAb, HisMab-1 (mouse IgG2b, kappa), by immunizing mice with recombinant proteins containing an N-terminal His-tag.	Histidine	143-146	immunoglobulin heavy constant gamma 2B	Mus musculus	58-63
34606713-4	2021	We use histidine-heme loop formation methods, employing eight single histidine variants, to probe for denatured state conformational bias of a UBA(1) domain fused to the N-terminus of iso-1-cytochrome c (iso-1-Cytc).	Histidine	7-16	eukaryotic translation initiation factor 1	Homo sapiens	204-214
30626284-6	2019	These data, together with molecular dynamics studies, indicate that the histidine is highly flexible, even when complexed with BECN1 BH3.	Histidine	72-81	beclin 1	Homo sapiens	127-132
34625786-10	2021	Moreover, the 6 x His tag provides a convenient tool for detecting the interactions of mouse CRP with ligands.	Histidine	18-21	C-reactive protein, pentraxin-related	Mus musculus	93-96
30826412-6	2019	The results showed that the GST-VP28, His-tagged Rab7 (His-Rab7) and His-beta-actin formed a tripartite complex.	Histidine	55-58	POTE ankyrin domain family member F	Homo sapiens	73-83
34117217-6	2021	Our data suggest that TRAF2 binds to PVQE motif residing in between the PEST and histidine repeat domain (HRD) of DYRK1A protein, and mediates K63-linked ubiquitination of DYRK1A.	Histidine	81-90	TNF receptor associated factor 2	Homo sapiens	22-27
30793391-2	2019	hZIP4 plasma membrane levels are regulated through post-translational modification of its large, disordered, histidine-rich cytosolic loop (ICL2) in response to intracellular zinc concentrations.	Histidine	109-118	solute carrier family 39 member 4	Homo sapiens	0-5
34122448-6	2021	The immunodominance of B-cell epitopes, total IgG titers and the levels of IFN-gamma and IL-17A from mice immunized with HI plus different adjuvants were different from each other, which may explain the difference in protective immunity observed in each immunized group.	Histidine	121-123	interleukin 17A	Mus musculus	89-95
31035643-9	2019	However, the amino acid substitution of histidine H38, which is not involved in PLA2 function, to alanine, also affects protease activity, suggesting that the active site/mechanism of the PLA2 and protease function are not identical.	Histidine	40-49	phospholipase A2 group IIA	Homo sapiens	188-192
34792001-6	2021	His-affinity resin, ion exchange and gel filtration chromatography were used to purify NEK7.	Histidine	0-3	NIMA related kinase 7	Homo sapiens	87-91
30819802-4	2019	The dehydrin Lti30 (Arabidopsis thaliana) is up-regulated during cold and drought stress conditions and comprises six K-segments, each with two adjacent histidines.	Histidine	153-163	dehydrin family protein	Arabidopsis thaliana	13-18
35144046-8	2022	In stability studies, (186Re)Re-2 remained intact through 7 d in l-cysteine and l-histidine.	Histidine	80-91	G protein-coupled receptor 161	Homo sapiens	29-33
30819802-5	2019	Lti30 interacts with the membrane electrostatically via pH-dependent protonation of the histidines.	Histidine	88-98	dehydrin family protein	Arabidopsis thaliana	0-5
30984480-10	2019	Indeed, truncated His-tagged HTU-LOX lacking the N-terminal hydrophobic signal peptide purified under denaturing conditions can be successfully refolded into an active enzyme, and a larger N-terminal truncation further increases the amine oxidase activity.	Histidine	18-21	lysyl oxidase	Homo sapiens	33-36
35524873-6	2022	Soluble His-CCL5 was successfully expressed with 0.1 mmol/L of isopropyl-beta-D-1-tiogalactopiranoside at 25 C and purified by affinity chromatography.	Histidine	8-11	C-C motif chemokine ligand 5	Homo sapiens	12-16
30944256-5	2019	Administration of histidine-tagged sPRR, sPRR-His, stimulated V2R expression and also reversed the inhibitory effect of PF-429242 on the expression induced by AVP.	Histidine	18-27	arginine vasopressin receptor 2	Mus musculus	62-65
35229720-2	2022	Histamine, a monoamine neurotransmitter, is synthesized through decarboxylation of histidine by histidine decarboxylase (Hdc).	Histidine	83-92	Histidine decarboxylase	Drosophila melanogaster	96-119
35229720-2	2022	Histamine, a monoamine neurotransmitter, is synthesized through decarboxylation of histidine by histidine decarboxylase (Hdc).	Histidine	83-92	Histidine decarboxylase	Drosophila melanogaster	121-124
35222471-4	2022	Here, we report that recombinant histidine (His)-AtPTP1 protein activity is directly inhibited by H2O2 and nitric oxide (NO) exogenous treatments.	Histidine	33-42	protein tyrosine phosphatase 1	Arabidopsis thaliana	49-55
35222471-4	2022	Here, we report that recombinant histidine (His)-AtPTP1 protein activity is directly inhibited by H2O2 and nitric oxide (NO) exogenous treatments.	Histidine	44-47	protein tyrosine phosphatase 1	Arabidopsis thaliana	49-55
30944256-5	2019	Administration of histidine-tagged sPRR, sPRR-His, stimulated V2R expression and also reversed the inhibitory effect of PF-429242 on the expression induced by AVP.	Histidine	46-49	arginine vasopressin receptor 2	Mus musculus	62-65
30988643-9	2019	The effect of a PP13 variant with a histidine-tag (His-PP13) remained the same between 7 and 13 days.	Histidine	36-45	galectin 13	Homo sapiens	16-20
30988643-9	2019	The effect of a PP13 variant with a histidine-tag (His-PP13) remained the same between 7 and 13 days.	Histidine	36-45	galectin 13	Homo sapiens	55-59
30988643-9	2019	The effect of a PP13 variant with a histidine-tag (His-PP13) remained the same between 7 and 13 days.	Histidine	51-54	galectin 13	Homo sapiens	16-20
30988643-9	2019	The effect of a PP13 variant with a histidine-tag (His-PP13) remained the same between 7 and 13 days.	Histidine	51-54	galectin 13	Homo sapiens	55-59
30902068-8	2019	The resulting Dr-dUTPase had the leading peptide Gly-Ser-His- originating from the vector at the amino terminus, and a mutation, Arg66Lys, to remove the internal thrombin site.	Histidine	57-60	Deoxyuridine triphosphatase	Drosophila melanogaster	17-24
30886237-2	2019	To explore the role of histidine protonation in the binding process, the pH-dependence of bile salt binding and internal dynamics in hI-BABP was investigated using NMR spectroscopy and biophysical tools.	Histidine	23-32	fatty acid binding protein 6	Homo sapiens	133-140
30701963-6	2019	Ab-MB served as a sensing probe for the competitive immunorecognitions between known concentrations of His-tag RGS11 and unknown concentrations of target RGS11 in serum.	Histidine	103-106	regulator of G protein signaling 11	Homo sapiens	111-116
32216237-5	2019	Yeast two-hybrid assay showed the growth of SPAG6 and SPINK2 in the selective culture medium SD/-Leu/-Trp/-His, and the transfection of the CHO cells revealed the co-localization of SPAG6 and SPINK2 around the nuclei.	Histidine	107-110	sperm-associated antigen 6	Cricetulus griseus	44-49
30600941-6	2019	On the other hand, the system of [Eu(pda)2 ]- with histidine favors hetero-allosteric association over homo-association.	Histidine	51-60	transcription factor AP-2 beta	Homo sapiens	37-42
30278216-0	2019	Ligand chirality can affect histidine protonation of vitamin-D receptor: ab initio molecular orbital calculations in water.	Histidine	28-37	vitamin D receptor	Homo sapiens	53-71
30278216-6	2019	The FMO results reveal that two histidine residues of VDR contribute significantly to the binding between VDR and ligand and that their protonation states can affect the specific interactions between VDR and ligand.	Histidine	32-41	vitamin D receptor	Homo sapiens	54-57
30278216-6	2019	The FMO results reveal that two histidine residues of VDR contribute significantly to the binding between VDR and ligand and that their protonation states can affect the specific interactions between VDR and ligand.	Histidine	32-41	vitamin D receptor	Homo sapiens	106-109
30278216-6	2019	The FMO results reveal that two histidine residues of VDR contribute significantly to the binding between VDR and ligand and that their protonation states can affect the specific interactions between VDR and ligand.	Histidine	32-41	vitamin D receptor	Homo sapiens	106-109
30278216-8	2019	The results illustrate the possibility that the difference in the chirality of a ligand can induce the change in protonation states of the histidine residues of VDR existing near the ligand.	Histidine	139-148	vitamin D receptor	Homo sapiens	161-164
30287244-3	2019	All members share a common catalytic mechanism, which involves a conserved catalytic triad, constituted by two histidines and a lysine (His15/His122/Lys38 in RNase6 corresponding to His12/His119/Lys41 in RNaseA).	Histidine	111-121	ribonuclease A family member k6	Homo sapiens	158-164
30287244-4	2019	Recently, our first crystal structure of human RNase6 identified an additional His pair (His36/His39) and suggested the presence of a secondary active site.	Histidine	79-82	ribonuclease A family member k6	Homo sapiens	47-53
31172469-2	2019	Referred to as cytochrome b558, because of its signature spectral absorbance at 558 nm in reduced-minus-oxidized difference spectroscopy, or cytochrome b(-245), because of its very low midpoint potential of -245 mV at pH 7.0, the protein possesses two stacked inequivalent hemes ligated by pairs of histidine residues in membrane helices h3 and h5.	Histidine	299-308	mitochondrially encoded cytochrome b	Homo sapiens	15-27
30474742-0	2018	Expression, purification, and evaluation of in vivo anti-fibrotic activity for soluble truncated TGF-beta receptor II as a cleavable His-SUMO fusion protein.	Histidine	133-136	transforming growth factor, beta receptor II	Mus musculus	97-117
30337625-3	2018	The results showed that, compared with six commercial plasmids, pHH-GM1 significantly enhanced His-HA-ALPK1 expression in a western blot analysis of transfected HEK293T cells.	Histidine	95-98	alpha kinase 1	Homo sapiens	102-107
30230320-3	2018	Here, we characterized the structural features of histidines in the chemokines CXCL8 and CXCL1 in the free, GAG heparin-bound, and CXCR2 receptor N-terminal domain-bound states using solution NMR spectroscopy.	Histidine	50-60	C-X-C motif chemokine ligand 1	Homo sapiens	89-94
30230320-4	2018	CXCL8 and CXCL1 share two conserved histidines, one in the N-loop and the other in the 30s loop.	Histidine	36-46	C-X-C motif chemokine ligand 1	Homo sapiens	10-15
30230320-6	2018	On the other hand, in unliganded CXCL1, each of the two histidines exists in two states, as the neutral Nepsilon2 tautomer and charged imidazolium.	Histidine	56-66	C-X-C motif chemokine ligand 1	Homo sapiens	33-38
30173739-4	2018	Next, the amino acids including His-159 in nsp1beta, and His-129, His-144 and Lys-173 in nsp11 were determined to play crucial roles in the reduction of CH25H.	Histidine	32-35	cholesterol 25-hydroxylase	Homo sapiens	153-158
30173739-4	2018	Next, the amino acids including His-159 in nsp1beta, and His-129, His-144 and Lys-173 in nsp11 were determined to play crucial roles in the reduction of CH25H.	Histidine	57-60	cholesterol 25-hydroxylase	Homo sapiens	153-158
30173739-4	2018	Next, the amino acids including His-159 in nsp1beta, and His-129, His-144 and Lys-173 in nsp11 were determined to play crucial roles in the reduction of CH25H.	Histidine	57-60	cholesterol 25-hydroxylase	Homo sapiens	153-158
29764940-10	2018	The revised two-base catalytic mechanism may involve His-125 (Glu-134 in GNE), as suggested by mutant activity analysis.	Histidine	53-56	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	73-76
29872214-1	2018	Zinc modulates the biological function of histidine-rich glycoprotein (HRG) through binding to its His-rich region (HRR).	Histidine	99-102	histidine rich glycoprotein	Homo sapiens	71-74
29744598-8	2018	In contrast, the overall size of interferon-tau was determined by AF4 to decrease in the presence of histidine, which is known to bind to the native state, thereby providing conformational stabilization.	Histidine	101-110	AF4/FMR2 family member 1	Homo sapiens	66-69
29744598-9	2018	Addition of histidine as the buffer resulted in formation of fewer subvisible particles over time at 50 C. Finally, the thermal aggregation was monitored using AF4 and the rate constants were found to be comparable to those determined previously by SEC and DLS.	Histidine	12-21	AF4/FMR2 family member 1	Homo sapiens	160-163
29489419-3	2018	This insert mutation introduces five additional amino acid residues YAVHY after histidine at the 95 site (p.H95_A96insYAVHY) within the second transmembrane (TM2) domain of Cx50 protein (Cx50-insert).	Histidine	80-89	gap junction protein alpha 8	Homo sapiens	173-177
30277418-0	2018	Hb Hubei [alpha114(GH2)Pro His, HBA1: c.344C&gt;A]: A Novel Hemoglobin Variant of the alpha1-Globin Chain.	Histidine	27-30	growth hormone 2	Homo sapiens	19-22
30277418-1	2018	We report here a novel alpha1-globin chain variant, Hb Hubei [alpha114(GH2)Pro His, HBA1: c.344C&gt;A], in a Chinese individual.	Histidine	79-82	growth hormone 2	Homo sapiens	71-74
29176272-8	2018	This inverse correlation was more evident among the ADH1B His/His + ALDH2 Glu/Lys or Lys/Lys groups (-3.24 mg/dL, 95% CI, -5.03 to -1.45).	Histidine	58-61	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	52-57
29176272-8	2018	This inverse correlation was more evident among the ADH1B His/His + ALDH2 Glu/Lys or Lys/Lys groups (-3.24 mg/dL, 95% CI, -5.03 to -1.45).	Histidine	62-65	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	52-57
29561549-5	2018	While palladium acetate was able to generate oscillations under the conditions already established in our previous research on PdI2-catalysed oscillators, the other two catalysts needed the addition of HI to induce oscillations.	Histidine	202-204	peptidyl arginine deiminase 2	Homo sapiens	127-131
29463709-4	2018	Biochemical studies showed that the GAS41 YEATS domain presents significant binding affinity toward H3K122suc upon a protonated histidine residue.	Histidine	128-137	YEATS domain containing 4	Homo sapiens	36-41
29463709-6	2018	To investigate the binding mechanism, we solved the crystal structure of the YEATS domain of Yaf9, the GAS41 homolog, in complex with an H3K122suc peptide that demonstrated the presence of a salt bridge formed when a protonated histidine residue (His39) recognizes the carboxyl terminal of the succinyl group.	Histidine	228-237	YEATS domain containing 4	Homo sapiens	93-97
29463709-6	2018	To investigate the binding mechanism, we solved the crystal structure of the YEATS domain of Yaf9, the GAS41 homolog, in complex with an H3K122suc peptide that demonstrated the presence of a salt bridge formed when a protonated histidine residue (His39) recognizes the carboxyl terminal of the succinyl group.	Histidine	228-237	YEATS domain containing 4	Homo sapiens	103-108
29350903-1	2018	In this work, a typical cylinder-shaped tobacco mosaic virus coat protein (TMVCP) is employed as an anisotropic building block to assemble into triclinic and hexagonal close-packed (HCP) protein crystals by introducing cysteine residues at the 1 and 3 sites and four histidine residues at the C-terminal, respectively.	Histidine	267-276	Coat protein	Tobacco mosaic virus	61-73
29127553-0	2018	Identification of Histidine 303 as the Catalytic Base of Lysyl Oxidase via Site-Directed Mutagenesis.	Histidine	18-27	lysyl oxidase	Homo sapiens	57-70
29370305-7	2018	Results show that three different mutations affecting histidine at position 12 affected Env incorporation into virions that correlated with reduction of virus infectivity and DC-SIGN-mediated virus capture and transmission.	Histidine	54-63	endogenous retrovirus group K member 20	Homo sapiens	88-91
28811265-6	2017	Heterologous expression of Gm gamma-TMT in pET29a expression vector under the control of bacteriophage T7 promoter produced a 37.9 kDa recombinant Gm gamma-TMT protein with histidine hexamer tag at its C-terminus.	Histidine	173-182	gamma-tocopherol methyltransferase	Glycine max	30-39
28811265-6	2017	Heterologous expression of Gm gamma-TMT in pET29a expression vector under the control of bacteriophage T7 promoter produced a 37.9 kDa recombinant Gm gamma-TMT protein with histidine hexamer tag at its C-terminus.	Histidine	173-182	gamma-tocopherol methyltransferase	Glycine max	150-159
29032653-3	2017	Bacterial hormone-sensitive lipases (bHSLs), which are homologous to the C-terminal domain of HSL, have alpha/beta-hydrolase fold with a catalytic triad composed of His, Asp, and Ser.	Histidine	165-168	lipase E, hormone sensitive type	Homo sapiens	38-41
28813605-4	2017	Substituting diaminopropionic acid (Dap), DDap, and His at the Asn position yielded potent MC4R ligands, while replacing Ala with Ser maintained MC4R potency.	Histidine	52-55	melanocortin 4 receptor	Homo sapiens	91-95
28741928-2	2017	Iterative deconvolution in solution of synthesized modified pentapeptides yielded two potent HtrA3 activators acting in the micromolar range (HCOO-CH2O-C6H4-OCH2-CO-Tyr-Asn-Phe-His-Asn-OH and HCOO-CH2O-C6H4-OCH2-CO-Tyr-Asn-Phe-His-Glu-OH).	Histidine	177-180	HtrA serine peptidase 3	Homo sapiens	93-98
27535568-10	2017	In the 0.75 g/kg L-histidine group, a significant increase in the number of Fos-ir cells was detected only in the NTS.	Histidine	17-28	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	76-79
28488337-6	2017	Porous laminin (LN)-rich sponge (LN-sponge), on which histidine-tagged VEGF (VEGF-Histag) is immobilized via affinity interaction is developed.	Histidine	54-63	vascular endothelial growth factor A	Mus musculus	71-75
28488337-6	2017	Porous laminin (LN)-rich sponge (LN-sponge), on which histidine-tagged VEGF (VEGF-Histag) is immobilized via affinity interaction is developed.	Histidine	54-63	vascular endothelial growth factor A	Mus musculus	77-88
28202352-11	2017	We found that SLC38A3 decreased the cellular concentrations of glutamine and histidine, and the deficiency of glutamine or histidine activated PDK1/AKT signaling that in turn, triggered NSCLC metastasis.	Histidine	123-132	pyruvate dehydrogenase kinase 1	Homo sapiens	143-147
28469631-7	2017	All of the PtZIP proteins contained the highly conserved ZIP signature sequences in TM-IV, and nine of them showed a variable region rich in histidine residues between TM-III and TM-IV.	Histidine	141-150	Argonaute family protein	Arabidopsis thaliana	13-16
28323994-5	2017	We have further discovered that the histidine ammonia-lyase (HAL; also known as histidase or histidinase)-2 gene is strongly and specifically activated by T3 in the proliferating adult stem cells of the intestine during metamorphosis, implicating a role of histidine catabolism in the development of adult intestinal stem cells.	Histidine	36-45	histidine ammonia-lyase, gene 1 L homeolog	Xenopus laevis	61-64
28030949-3	2017	Compared to that in the NCS-1 protein of Caenorhabditis elegans, evolution has avoided the placement of histidine residues at positions 102 and 83 in the NCS-1 protein of humans and Xenopus laevis, possibly to decrease the conformational sensitivity to pH gradients in synaptic processes.	Histidine	104-113	Neuronal calcium sensor 1	Caenorhabditis elegans	24-29
28030949-3	2017	Compared to that in the NCS-1 protein of Caenorhabditis elegans, evolution has avoided the placement of histidine residues at positions 102 and 83 in the NCS-1 protein of humans and Xenopus laevis, possibly to decrease the conformational sensitivity to pH gradients in synaptic processes.	Histidine	104-113	Neuronal calcium sensor 1	Caenorhabditis elegans	154-159
28088197-8	2017	The methanol inducible promoter AOX1 was used to drive expression of the native and histidine tagged forms of pro-relaxin H2 in dual phase fed-batch experiments on the 22 L scale.	Histidine	84-93	relaxin 2	Homo sapiens	110-124
27825818-3	2016	Therefore, ligand binding to the Ngb metal center is limited from the dissociation of the distal His(E7)64-Fe bond.	Histidine	97-100	neuroglobin	Homo sapiens	33-36
27775717-7	2016	We used directed mutagenesis to characterize SCAF1 regions that interact with CIII and CIV and discovered that this interaction requires the correct orientation of a histidine residue at position 73 that is altered in the short isoform of SCAF1, explaining its inability to interact with CIV.	Histidine	166-175	SR-related CTD-associated factor 1	Mus musculus	45-50
27775717-7	2016	We used directed mutagenesis to characterize SCAF1 regions that interact with CIII and CIV and discovered that this interaction requires the correct orientation of a histidine residue at position 73 that is altered in the short isoform of SCAF1, explaining its inability to interact with CIV.	Histidine	166-175	SR-related CTD-associated factor 1	Mus musculus	239-244
27750195-13	2016	As well, it was shown that the extra cellular acidosis led to the protonation of the TRAIL residue histidine by flipping the His switch to the on position with a concomitant decrease in affinity for DR4 and DR5 receptors.	Histidine	99-108	major histocompatibility complex, class II, DR beta 4	Homo sapiens	199-202
27648609-6	2016	Furthermore, peptide CT-2 (Leu-Gln-Pro-Ser-His-Tyr) potently inhibited melanogenesis in mouse B16 melanoma cells without causing cytotoxicity, suggesting the potential of CT-2 as an agent for melanin-related skin disorder treatment.	Histidine	43-46	cardiotrophin 2	Mus musculus	21-25
27648609-6	2016	Furthermore, peptide CT-2 (Leu-Gln-Pro-Ser-His-Tyr) potently inhibited melanogenesis in mouse B16 melanoma cells without causing cytotoxicity, suggesting the potential of CT-2 as an agent for melanin-related skin disorder treatment.	Histidine	43-46	cardiotrophin 2	Mus musculus	171-175
27661977-7	2016	Hexacoordinate hemoglobins such as neuroglobin are limited by tighter histidine coordination that blocks hydroxylamine binding, and pentacoordinate hemoglobins have intrinsically lower hydroxylamine affinities.	Histidine	70-79	neuroglobin	Homo sapiens	35-46
27543355-0	2016	Circumvention of P-gp and MRP2 mediated efflux of lopinavir by a histidine based dipeptide prodrug.	Histidine	65-74	ATP binding cassette subfamily C member 2	Homo sapiens	26-30
27722449-6	2016	The order of reactivity of the studied small biomolecules is: 5"-GMP &gt; GSH &gt; l-Met &gt; l-His.	Histidine	94-99	5'-nucleotidase, cytosolic II	Homo sapiens	65-68
27453504-3	2016	We identify an association between GMPS and xanthosine using single variant analysis and associations between HAL and histidine, PAH and phenylalanine, and UPB1 and ureidopropionate using gene-based tests (P&lt;5 x 10(-8) in meta-analysis), highlighting novel coding variants that may underlie inborn errors of metabolism.	Histidine	118-127	histidine ammonia-lyase	Homo sapiens	110-113
26931411-7	2016	Cav3.2 channels are modulated by low concentrations of metal ions (nickel, zinc) and redox agents, which involves the histidine 191 (H191) in the channel"s extracellular IS3-IS4 loop.	Histidine	118-127	calcium channel, voltage-dependent, T type, alpha 1H subunit	Mus musculus	0-6
27250920-3	2016	This combined computational-experimental study demonstrates that histidine-547 (H547) of hDAT plays a crucial role in the hDAT-Tat binding and dopamine uptake by hDAT, and that the H547A mutation can not only considerably attenuate Tat-induced inhibition of dopamine uptake, but also significantly increase the Vmax of hDAT for dopamine uptake.	Histidine	65-74	solute carrier family 6 member 3	Homo sapiens	89-93
27250920-3	2016	This combined computational-experimental study demonstrates that histidine-547 (H547) of hDAT plays a crucial role in the hDAT-Tat binding and dopamine uptake by hDAT, and that the H547A mutation can not only considerably attenuate Tat-induced inhibition of dopamine uptake, but also significantly increase the Vmax of hDAT for dopamine uptake.	Histidine	65-74	solute carrier family 6 member 3	Homo sapiens	122-126
27250920-3	2016	This combined computational-experimental study demonstrates that histidine-547 (H547) of hDAT plays a crucial role in the hDAT-Tat binding and dopamine uptake by hDAT, and that the H547A mutation can not only considerably attenuate Tat-induced inhibition of dopamine uptake, but also significantly increase the Vmax of hDAT for dopamine uptake.	Histidine	65-74	solute carrier family 6 member 3	Homo sapiens	122-126
27250920-3	2016	This combined computational-experimental study demonstrates that histidine-547 (H547) of hDAT plays a crucial role in the hDAT-Tat binding and dopamine uptake by hDAT, and that the H547A mutation can not only considerably attenuate Tat-induced inhibition of dopamine uptake, but also significantly increase the Vmax of hDAT for dopamine uptake.	Histidine	65-74	solute carrier family 6 member 3	Homo sapiens	122-126
27013146-5	2016	Three sulfate anions bound to RNase 6 were found, interacting with residues at the main active site (His(15), His(122) and Gln(14)) and cationic surface-exposed residues (His(36), His(39), Arg(66) and His(67)).	Histidine	101-104	ribonuclease A family member k6	Homo sapiens	30-37
27013146-5	2016	Three sulfate anions bound to RNase 6 were found, interacting with residues at the main active site (His(15), His(122) and Gln(14)) and cationic surface-exposed residues (His(36), His(39), Arg(66) and His(67)).	Histidine	110-113	ribonuclease A family member k6	Homo sapiens	30-37
27013146-5	2016	Three sulfate anions bound to RNase 6 were found, interacting with residues at the main active site (His(15), His(122) and Gln(14)) and cationic surface-exposed residues (His(36), His(39), Arg(66) and His(67)).	Histidine	110-113	ribonuclease A family member k6	Homo sapiens	30-37
27013146-5	2016	Three sulfate anions bound to RNase 6 were found, interacting with residues at the main active site (His(15), His(122) and Gln(14)) and cationic surface-exposed residues (His(36), His(39), Arg(66) and His(67)).	Histidine	110-113	ribonuclease A family member k6	Homo sapiens	30-37
27013146-5	2016	Three sulfate anions bound to RNase 6 were found, interacting with residues at the main active site (His(15), His(122) and Gln(14)) and cationic surface-exposed residues (His(36), His(39), Arg(66) and His(67)).	Histidine	110-113	ribonuclease A family member k6	Homo sapiens	30-37
27013146-9	2016	Interestingly, the RNase 6 crystal structure revealed a novel secondary active site conformed by the His(36)-His(39) dyad that facilitates the polynucleotide substrate catalysis.	Histidine	101-104	ribonuclease A family member k6	Homo sapiens	19-26
27013146-9	2016	Interestingly, the RNase 6 crystal structure revealed a novel secondary active site conformed by the His(36)-His(39) dyad that facilitates the polynucleotide substrate catalysis.	Histidine	109-112	ribonuclease A family member k6	Homo sapiens	19-26
26928127-3	2016	YPQ1 and AVT1, which are involved in the vacuolar uptake of lysine/arginine and histidine, respectively, were deleted in addition to ypq2Delta and ypq3Delta.	Histidine	80-89	cationic amino acid transporter	Saccharomyces cerevisiae S288C	0-4
26992901-9	2016	ADH1B His/Arg had an OR of 1.98 (1.20-3.24, P = 0.007) compared with His/His.	Histidine	6-9	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	0-5
27206388-8	2016	hPLSCR1 has five histidine residues and point mutations of histidine residues to alanine in hPLSCR1 resulted in 60 % loss in nuclease activity.	Histidine	17-26	phospholipid scramblase 1	Homo sapiens	0-7
27206388-8	2016	hPLSCR1 has five histidine residues and point mutations of histidine residues to alanine in hPLSCR1 resulted in 60 % loss in nuclease activity.	Histidine	59-68	phospholipid scramblase 1	Homo sapiens	92-99
27206388-9	2016	Thus histidine residues could play a critical role in the nuclease activity of hPLSCR1.	Histidine	5-14	phospholipid scramblase 1	Homo sapiens	79-86
26969165-2	2016	We have previously shown that potentiation of CNGA1 channels by transition metals requires a histidine in the A" helix following the S6 transmembrane segment.	Histidine	93-102	cyclic nucleotide gated channel subunit alpha 1	Homo sapiens	46-51
26918510-2	2016	Histidine-tagged (His6) VC1-RAGE domain was covalently bonded to Cu(II) or Ni(II) complexes with dipyrromethene (DPM) self-assembled on gold surface.	Histidine	0-9	advanced glycosylation end-product specific receptor	Homo sapiens	28-32
27088325-4	2016	Relative to the open bacterial ammonium transporters, non-phosphorylated Mep2 exhibits shifts in cytoplasmic loops and the C-terminal region (CTR) to occlude the cytoplasmic exit of the channel and to interact with His2 of the twin-His motif.	Histidine	215-218	ammonium permease MEP2	Saccharomyces cerevisiae S288C	73-77
26691197-2	2016	There are three known Vssc alleles that confer resistance to pyrethroids in the house fly: knock down resistance (kdr; L1014F), super-kdr (M918T + L1014F) and kdr-his (L1014H), but there has been no side-by-side comparison of the resistance levels that they confer.	Histidine	163-166	sodium channel protein para-like	Musca domestica	22-26
26826131-1	2016	Rpl3, a highly conserved ribosomal protein, is methylated at histidine 243 by the Hpm1 methyltransferase in Saccharomyces cerevisiae.	Histidine	61-70	ribosomal 60S subunit protein L3	Saccharomyces cerevisiae S288C	0-4
26826131-2	2016	Histidine 243 lies close to the peptidyl transferase center in a functionally important region of Rpl3 designated as the basic thumb that coordinates the decoding, peptidyl transfer, and translocation steps of translation elongation.	Histidine	0-9	ribosomal 60S subunit protein L3	Saccharomyces cerevisiae S288C	98-102
26960429-6	2016	When histidine residues in both the intracellular and extracellular region of hTAS1R2 were exchanged for alanine, taste-modifying effect of MCL was reduced or abolished.	Histidine	5-14	taste 1 receptor member 2	Homo sapiens	78-85
26657863-6	2016	Progesterone receptor membrane component-1 (PGRMC1) was required for HIS-dependent increases in hepcidin biosynthesis, as PGRMC1 depletion in cultured hepatoma cells and zebrafish blocked the ability of HISs to increase hepcidin mRNA levels.	Histidine	69-72	hepcidin antimicrobial peptide	Mus musculus	220-228
26468287-9	2015	The specificity for binding to LC3A/B is due to the interaction between Asp(1285) in FYCO1 and His(57) in LC3B.	Histidine	95-98	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	31-37
26478267-8	2015	An immunoelectron microscopy assay revealed that MGT5-His is localized to the plasma membrane of the tapetum.	Histidine	54-57	magnesium transport 5	Arabidopsis thaliana	49-53
26081982-11	2015	Thus, reactive metabolites of diabetes upregulate CN1 activity by post-translational modifications, and thus decrease the availability of reactive metabolite-scavenging histidine dipeptides in the kidney in a positive feedback loop.	Histidine	169-178	carnosine dipeptidase 1 (metallopeptidase M20 family)	Mus musculus	50-53
26409900-2	2015	The multidomain arrangement of HPRG comprises two modules at the N-terminus that are homologous to cystatin but void of cysteine proteinase inhibitor function, and a second half consisting of a histidine-proline-rich region (HPRR) located between two proline-rich regions (PRR1 and PRR2), and a C-terminus domain.	Histidine	194-203	histidine rich glycoprotein	Homo sapiens	31-35
26397724-4	2015	Molecular docking of 1 to an X-ray structure of CXCR4 showed that the l-Arg guanidino group of 1 forms polar interactions with His(113) and Asp(171) and the (pyridin-2-ylmethyl)amino moiety is anchored by Asp(262) and His(281), whereas the naphthalene ring is tightly packed in a hydrophobic subpocket formed by the aromatic side chains of Trp(94), Tyr(45), and Tyr(116).	Histidine	127-130	C-X-C motif chemokine receptor 4	Homo sapiens	48-53
26397724-4	2015	Molecular docking of 1 to an X-ray structure of CXCR4 showed that the l-Arg guanidino group of 1 forms polar interactions with His(113) and Asp(171) and the (pyridin-2-ylmethyl)amino moiety is anchored by Asp(262) and His(281), whereas the naphthalene ring is tightly packed in a hydrophobic subpocket formed by the aromatic side chains of Trp(94), Tyr(45), and Tyr(116).	Histidine	218-221	C-X-C motif chemokine receptor 4	Homo sapiens	48-53
26305187-3	2015	To further study RTVP-1 effects we performed a pull-down assay using His-tagged RTVP-1 followed by mass spectrometry and found that RTVP-1 was associated with the actin polymerization regulator, N-WASP.	Histidine	69-72	GLI pathogenesis related 1	Homo sapiens	17-23
26305187-3	2015	To further study RTVP-1 effects we performed a pull-down assay using His-tagged RTVP-1 followed by mass spectrometry and found that RTVP-1 was associated with the actin polymerization regulator, N-WASP.	Histidine	69-72	GLI pathogenesis related 1	Homo sapiens	80-86
26305187-3	2015	To further study RTVP-1 effects we performed a pull-down assay using His-tagged RTVP-1 followed by mass spectrometry and found that RTVP-1 was associated with the actin polymerization regulator, N-WASP.	Histidine	69-72	GLI pathogenesis related 1	Homo sapiens	80-86
25781680-3	2015	This is exemplified with recombinant his-tagged rhodopsin, which is rapidly extracted from its host membrane and directly assembled into membrane scaffold protein (MSP) nanodiscs.	Histidine	1-4	microseminoprotein beta	Homo sapiens	137-162
25781680-3	2015	This is exemplified with recombinant his-tagged rhodopsin, which is rapidly extracted from its host membrane and directly assembled into membrane scaffold protein (MSP) nanodiscs.	Histidine	1-4	microseminoprotein beta	Homo sapiens	164-167
25980622-9	2015	In a protein transduction study, green fluorescence protein fused to the H16 peptide (GFP-H16) was purified by Ni-NTA chromatography, detected using an anti-His-tag antibody and internalized into cells.	Histidine	157-160	H1.6 linker histone, cluster member	Homo sapiens	73-76
25980622-9	2015	In a protein transduction study, green fluorescence protein fused to the H16 peptide (GFP-H16) was purified by Ni-NTA chromatography, detected using an anti-His-tag antibody and internalized into cells.	Histidine	157-160	H1.6 linker histone, cluster member	Homo sapiens	90-93
25980622-10	2015	This serial process reveals that H16 functions as a His-tag and protein transduction domain.	Histidine	52-55	H1.6 linker histone, cluster member	Homo sapiens	33-36
26144885-1	2015	5-Aminoimidazole-4-carboxamide ribonucleotide (known as ZMP) is a metabolite produced in de novo purine biosynthesis and histidine biosynthesis, but only utilized in the cell by a homodimeric bifunctional enzyme (called ATIC) that catalyzes the last two steps of de novo purine biosynthesis.	Histidine	121-130	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	Mus musculus	220-224
25497832-2	2015	The protein sequence of yellow catfish SCD1 and Fads2 (Delta6) possessed all the characteristics of microsomal fatty acid Fads2 (Delta6), including three histidine boxes, two transmembrane regions and one N-terminal cytochrome b5 domain containing heme-binding motif.	Histidine	154-163	stearoyl-CoA desaturase	Homo sapiens	39-43
25962097-0	2015	A conserved histidine modulates HSPB5 structure to trigger chaperone activity in response to stress-related acidosis.	Histidine	12-21	crystallin alpha B	Homo sapiens	32-37
25542299-9	2015	RESULTS: Significantly superior activities were found in 34 of the approximately 2000 mutants analyzed, and the majority of the superior GSTs featured His and Gly residues in one of the three active-site positions subjected to mutagenesis.	Histidine	151-154	glutathione S-transferase alpha 2	Homo sapiens	137-141
25225131-7	2015	This observation was due to the protonation of a histidine residue as an imidazolium cation, which was not accessible when TTR was in its tetrameric structure.	Histidine	49-58	transthyretin	Homo sapiens	123-126
25762074-3	2015	Docking analysis of MAD-28 to mNT/NAF-1 revealed that in contrast to CLV, which formed a hydrogen bond network that stabilized the 2Fe-2S clusters of these proteins, MAD-28 broke the coordinative bond between the His ligand and the cluster"s Fe of mNT/NAF-1.	Histidine	213-216	CDGSH iron sulfur domain 2	Homo sapiens	34-39
25521423-0	2015	NMR studies of active-site properties of human carbonic anhydrase II by using (15) N-labeled 4-methylimidazole as a local probe and histidine hydrogen-bond correlations.	Histidine	132-141	carbonic anhydrase 2	Homo sapiens	47-68
25252293-3	2015	Particularly, the relation between 2827 A&gt;G polymorphism of the SIRT1 positioned on exon 2, leading to conversion of histidine to arginine, and the formation of CVD is not known yet.	Histidine	120-129	sirtuin 1	Homo sapiens	67-72
25554218-5	2015	ML-18 and EMY-98 inhibited specific (125)I-BA1 (DTyr-Gln-Trp-Ala-Val-betaAla-His-Phe-Nle-NH2)BB(6-14) binding to NCI-H1299 lung cancer cells stably transfected with BRS-3 with IC50 values of 4.8 and &gt;100muM, respectively.	Histidine	77-80	gastrin releasing peptide	Homo sapiens	93-95
25445692-4	2015	The histidines in the sequence of [D]-H6L9 allowed the peptide to get protonated under pH5.0 (mimicking the lysosome/endosome environment), and strong membrane lytic effect could thus be activated, leading to the escape of liposomes from the lysosomes and the decrease of of mir-10b expression.	Histidine	4-14	microRNA 10b	Mus musculus	275-282
25572553-2	2015	Among the PLA2 superfamily, secreted PLA2 (sPLA2) enzymes comprise the largest subfamily that includes 11 isoforms with a conserved His-Asp catalytic dyad.	Histidine	132-135	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	10-14
25572553-2	2015	Among the PLA2 superfamily, secreted PLA2 (sPLA2) enzymes comprise the largest subfamily that includes 11 isoforms with a conserved His-Asp catalytic dyad.	Histidine	132-135	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	37-41
25572553-2	2015	Among the PLA2 superfamily, secreted PLA2 (sPLA2) enzymes comprise the largest subfamily that includes 11 isoforms with a conserved His-Asp catalytic dyad.	Histidine	132-135	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	43-48
25058381-1	2014	Gaduscidin-1 and -2 (GAD-1 and GAD-2) are antimicrobial peptides (AMPs) that contain several histidine residues and are thus expected to exhibit pH-dependent activity.	Histidine	93-102	glutamate decarboxylase 1	Homo sapiens	21-26
25283071-0	2014	Mono-anionic phosphopeptides produced by unexpected histidine alkylation exhibit high Plk1 polo-box domain-binding affinities and enhanced antiproliferative effects in HeLa cells.	Histidine	52-61	polo like kinase 1	Homo sapiens	86-90
25185576-7	2014	DNA sequence analyses of FH domains 6 and 7 from macaques with high or low FH binding showed a polymorphism at residue 352 in domain 6, with Tyr being associated with high binding and His with low binding.	Histidine	184-187	complement factor H	Homo sapiens	25-27
25082511-0	2014	Mono- and di-halogenated histamine, histidine and carnosine derivatives are potent carbonic anhydrase I, II, VII, XII and XIV activators.	Histidine	36-45	carbonic anhydrase 1	Homo sapiens	83-112
24962580-6	2014	However, addition of two PAM residues (Arg(126)-His(127)) to the COOH terminus of VEK30 (VEK32) maintained a monomeric peptidic structure, but exhibited similar K2hPg binding affinity as full-length dimeric PAM.	Histidine	48-51	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	25-28
24962580-7	2014	We identified five residues in a1a2 (Arg(113), His(114), Glu(116), Arg(126), His(127)), mutation of which reduced PAM binding affinity for K2hPg by ~ 1000-fold.	Histidine	47-50	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	114-117
24962580-7	2014	We identified five residues in a1a2 (Arg(113), His(114), Glu(116), Arg(126), His(127)), mutation of which reduced PAM binding affinity for K2hPg by ~ 1000-fold.	Histidine	77-80	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	114-117
24858299-11	2014	At acidic pH (pH&lt;6.5), ionic and hydrophobic interactions, created by histidine protonation and hydrophobic amino acids, appeared in the Abeta/HSPG binding.	Histidine	73-82	syndecan 2	Homo sapiens	146-150
24865971-0	2014	Histidine methylation of yeast ribosomal protein Rpl3p is required for proper 60S subunit assembly.	Histidine	0-9	ribosomal 60S subunit protein L3	Saccharomyces cerevisiae S288C	49-54
24865971-2	2014	In the yeast Saccharomyces cerevisiae, the large ribosomal subunit protein Rpl3p is methylated at histidine 243, a residue that contacts the 25S rRNA near the P site.	Histidine	98-107	ribosomal 60S subunit protein L3	Saccharomyces cerevisiae S288C	75-80
24706759-8	2014	Substitution of Thr-30 and His-160 in GLUT1 to the corresponding positions in GLUT4 is sufficient to completely transform GLUT1 into GLUT4 with respect to indinavir inhibition of 2-DOG uptake and ATB-BMPA binding.	Histidine	27-30	solute carrier family 2 member 1	Homo sapiens	38-43
24706759-8	2014	Substitution of Thr-30 and His-160 in GLUT1 to the corresponding positions in GLUT4 is sufficient to completely transform GLUT1 into GLUT4 with respect to indinavir inhibition of 2-DOG uptake and ATB-BMPA binding.	Histidine	27-30	solute carrier family 2 member 4	Canis lupus familiaris	78-83
24706759-8	2014	Substitution of Thr-30 and His-160 in GLUT1 to the corresponding positions in GLUT4 is sufficient to completely transform GLUT1 into GLUT4 with respect to indinavir inhibition of 2-DOG uptake and ATB-BMPA binding.	Histidine	27-30	solute carrier family 2 member 1	Homo sapiens	122-127
24706759-8	2014	Substitution of Thr-30 and His-160 in GLUT1 to the corresponding positions in GLUT4 is sufficient to completely transform GLUT1 into GLUT4 with respect to indinavir inhibition of 2-DOG uptake and ATB-BMPA binding.	Histidine	27-30	solute carrier family 2 member 4	Canis lupus familiaris	133-138
24819655-5	2014	On the other hand, in the presence of L-histidine or L-arginine, [Eu(pda)2](-) exhibited intense CPL (glum ~ 0.08 for the (5)D0   (7)F1 transition at 0.10 mol dm(-3) of the amino acid), whereas quite weak CPL was observed for [Eu(bda)2](-) under the same conditions (glum &lt; 0.01).	Histidine	38-49	hephaestin	Homo sapiens	97-100
24754256-1	2014	Membrane transporter PhT2 (SLC15A3), which belongs to the proton-coupled oligopeptide transporter family, mediates the transport of di/tripeptides and histidine utilizing an inwardly directed proton gradient and negative membrane potential.	Histidine	151-160	solute carrier family 15 member 3	Homo sapiens	21-25
24506189-3	2014	Substitution of His66 in the blue fluorescent protein (BFP) with these histidine analogues created mutant proteins with distinct spectral properties.	Histidine	71-80	ring finger protein 112	Homo sapiens	55-58
24802942-5	2014	Overall, significantly elevated cancer risk was found when all studies were pooled into the meta-analysis of XPG Asp1104His (dominant model: OR = 1.05, 95% CI = 1.00-1.10; Asp/His vs. Asp/Asp: OR = 1.06, 95% CI = 1.01-1.11).	Histidine	120-123	ERCC excision repair 5, endonuclease	Homo sapiens	109-112
24782176-6	2014	RESULTS: Among the 87 identified studies examining genetic associations with MTX efficacy and toxicity, the reduced folate carrier 1 gene (RFC1) variant 80G&gt;A (Arg(27) His, rs1051266) was selected for random-effects meta-analysis.	Histidine	171-174	replication factor C subunit 1	Homo sapiens	139-143
24747442-0	2014	Immobilised histidine tagged beta2-adrenoceptor oriented by a diazonium salt reaction and its application in exploring drug-protein interaction using ephedrine and pseudoephedrine as probes.	Histidine	12-21	adrenoceptor beta 2	Homo sapiens	29-47
24736652-6	2014	LCAT presents a Ser/Asp/His catalytic triad with a peculiar geometry, which is shared with such other enzyme classes as lipases, proteases and esterases.	Histidine	24-27	lecithin-cholesterol acyltransferase	Homo sapiens	0-4
24342540-4	2014	Molecular simulation analysis suggest that the presence of Tyr or Glu may contribute to the formation of the breakwater network, the stabilization of distal histidine, the changes in the size of heme pocket, and eventually result in the inhibition of metHb formation.	Histidine	157-166	hemoglobin subunit gamma 2	Homo sapiens	251-256
23793398-4	2014	Thanks to the versatile affinity interactions between the (NTA)Cu(2+) complex and histidine- or biotin-tagged proteins, both tyrosinase and glucose oxidase were immobilized on the modified electrode.	Histidine	82-91	tyrosinase	Homo sapiens	125-135
24492416-4	2014	Remarkably, in full-length STIM1, replacement of Phe-394 with the dimensionally similar but polar histidine head group prevents both Orai1 binding and gating, creating an Orai1 non-agonist.	Histidine	98-107	ORAI calcium release-activated calcium modulator 1	Homo sapiens	133-138
24492416-4	2014	Remarkably, in full-length STIM1, replacement of Phe-394 with the dimensionally similar but polar histidine head group prevents both Orai1 binding and gating, creating an Orai1 non-agonist.	Histidine	98-107	ORAI calcium release-activated calcium modulator 1	Homo sapiens	171-176
23973428-4	2013	Pyrophosphate released by the amino acid-aaRS binding reaction was detected by luminol chemiluminescence; the method provided selective quantitation of 1.0-30 muM histidine and 1.0-60 muM lysine.	Histidine	163-172	alanyl-tRNA synthetase 1	Homo sapiens	41-45
24213606-5	2013	The co-existence of carnosine or His inhibited the expression of GADD34, p8, and Arc, although they did not influence the expression of the metal-related genes.	Histidine	33-36	protein phosphatase 1, regulatory subunit 15A	Mus musculus	65-71
23916489-2	2013	In this study, we successfully partially purified His-tagged tetherin with a glycophosphatidylinositol deletion (delGPI) and His-tagged full-length Vpu from transiently transfected 293T cells using affinity chromatography.	Histidine	50-53	bone marrow stromal cell antigen 2	Homo sapiens	61-69
24086538-1	2013	Mutated mouse lipoprotein lipase (LPL) containing a leucine (L) to histidine (H) substitution at position 452 was transferred into mouse liver by hydrodynamics-based gene delivery (HD).	Histidine	67-76	lipoprotein lipase	Mus musculus	14-32
24086538-1	2013	Mutated mouse lipoprotein lipase (LPL) containing a leucine (L) to histidine (H) substitution at position 452 was transferred into mouse liver by hydrodynamics-based gene delivery (HD).	Histidine	67-76	lipoprotein lipase	Mus musculus	34-37
23965744-5	2013	Blocking N-cadherin function using specific peptides that interfere with the histidine-alanine-valine extracellular homophilic interaction domain caused early pathologic changes characterized by disruption of zonula adherens and abnormal intracellular accumulation of N-cadherin.	Histidine	77-86	cadherin 2	Homo sapiens	9-19
23965744-5	2013	Blocking N-cadherin function using specific peptides that interfere with the histidine-alanine-valine extracellular homophilic interaction domain caused early pathologic changes characterized by disruption of zonula adherens and abnormal intracellular accumulation of N-cadherin.	Histidine	77-86	cadherin 2	Homo sapiens	268-278
23770703-6	2013	The overall fold of (BACCR)NAT3 and the geometry of its Cys-His-Glu catalytic triad are similar to those present in functional NATs.	Histidine	60-63	N-alpha-acetyltransferase 20, NatB catalytic subunit	Homo sapiens	27-31
23770703-9	2013	Computational analysis identified differences in residue packing and steric constraints in the active site of (BACCR)NAT3 that allow it to accommodate a Cys-His-Glu triad.	Histidine	157-160	N-alpha-acetyltransferase 20, NatB catalytic subunit	Homo sapiens	117-121
23831028-4	2013	The crystal structure of Dido3 PHD in complex with H3K4me3 reveals an atypical aromatic-cage-like binding site that contains a histidine residue.	Histidine	127-136	death inducer-obliterator 1	Homo sapiens	25-30
23589456-6	2013	HIS3, an essential enzyme for histidine biosynthesis, was placed exclusively under a GAL promoter, which is induced by galactose and strongly repressed in glucose.	Histidine	30-39	imidazoleglycerol-phosphate dehydratase HIS3	Saccharomyces cerevisiae S288C	0-4
23589456-10	2013	The new regulation of HIS3 tuned its expression according to histidine requirements with or without these significant mutations, indicating that additional factors participated in this regulation and that the regulatory network could reorganize in multiple ways to accommodate different mutations.	Histidine	61-70	imidazoleglycerol-phosphate dehydratase HIS3	Saccharomyces cerevisiae S288C	22-26
23564659-4	2013	On the basis of a peptide reported in the literature, referred to here as the Parent Peptide (H-Aib-Val-Aib-Glu-Ile-Gln-Leu-Nle-His-Gln-Har-NH2), we conducted systematic SAR analyses to investigate the effects of altering peptide hydrophobicity on PTH receptor functional potency as measured by the cAMP (cyclic adenosine monophosphate) accumulation and beta-arrestin recruitment assays.	Histidine	128-131	ANIB1	Homo sapiens	96-99
23564659-4	2013	On the basis of a peptide reported in the literature, referred to here as the Parent Peptide (H-Aib-Val-Aib-Glu-Ile-Gln-Leu-Nle-His-Gln-Har-NH2), we conducted systematic SAR analyses to investigate the effects of altering peptide hydrophobicity on PTH receptor functional potency as measured by the cAMP (cyclic adenosine monophosphate) accumulation and beta-arrestin recruitment assays.	Histidine	128-131	ANIB1	Homo sapiens	104-107
23330737-9	2013	Melatonin docked into the active site cleft of MMP-9 and interacted with key catalytic site residues including the three histidines that form the coordination complex with the catalytic zinc as well as proline 421 and alanine 191.	Histidine	121-131	matrix metallopeptidase 9	Homo sapiens	47-52
23517193-3	2013	In addition to simplifying the purification procedure, introduction of a His tag at either protein terminus dramatically increases its solubility, allowing preparation of concentrated, stable CcP samples required for multidimensional NMR spectroscopy.	Histidine	73-76	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	192-195
23517193-5	2013	The His-tagged CcP constructs remain catalytically active yet exhibit differences in the interaction with cytochrome c, the physiological binding partner, most likely because of steric occlusion of the high-affinity binding site by the C-terminal His tag.	Histidine	4-7	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	15-18
23031341-11	2013	Four different AsaP1 mutants (AsaP1(E294A), AsaP1(E294Q), AsaP1(Y309A), and AsaP1(Y309F)) were successfully constructed by one step site directed mutagenesis, expressed in E. coli BL21 C43 as pre-pro-proteins and purified by His-tag affinity chromatography and gel filtration.	Histidine	225-228	LOW QUALITY PROTEIN: arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1a	Salmo salar	15-20
23355523-5	2013	Disease-causing mutations were identified in three of the probands: a novel single-nucleotide deletion in both KLK4 alleles (g.6930delG; c.245delG; p.Gly82Alafs*87) that shifted the reading frame, a novel missense transition mutation in both MMP20 alleles (g.15390A&gt;G; c.611A&gt;G; p.His204Arg) that substituted arginine for an invariant histidine known to coordinate a structural zinc ion, and a previously described nonsense transition mutation in a single allele of FAM83H (c.1379G&gt;A; g.5663G&gt;A; p.W460*).	Histidine	341-350	kallikrein related-peptidase 4 (prostase, enamel matrix, prostate)	Mus musculus	111-115
23795473-5	2013	Deletion of the transcriptional regulator gene purR increased the biomass produced and maintained the level of histidine production per cell under the fermentation conditions used.	Histidine	111-120	DNA-binding transcriptional repressor PurR	Escherichia coli str. K-12 substr. MG1655	47-51
23390665-3	2004	It shares an identical C-terminal region (-Trp-Ala-Val-Gly-His-Leu-Met-NH2) with gastrin-releasing peptide (GRP), which is responsible for receptor binding and signal transduction (4, 5).	Histidine	59-62	gastrin releasing peptide	Homo sapiens	81-106
23390665-3	2004	It shares an identical C-terminal region (-Trp-Ala-Val-Gly-His-Leu-Met-NH2) with gastrin-releasing peptide (GRP), which is responsible for receptor binding and signal transduction (4, 5).	Histidine	59-62	gastrin releasing peptide	Homo sapiens	108-111
23276281-4	2013	We demonstrate that the unusual His(4) motif (site 2) formed at the S100A8/S100A9 dimer interface is the site of high-affinity Mn(II) coordination.	Histidine	32-35	S100 calcium binding protein A9	Homo sapiens	75-81
23142425-9	2013	Subjects carrying the UGT2B7 268 His/Tyr or Tyr/Tyr genotype had significantly lower total NNAL than those carrying His/His genotype.	Histidine	33-36	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	22-28
23291761-2	2013	Here we identified common amino acid sequences predicted from coding exons of the FGF4 gene in five pigs of two breeds, and HispFGF4, a 6x histidine-tagged porcine FGF4, was produced in Escherichia coli.	Histidine	139-148	fibroblast growth factor 4	Sus scrofa	128-132
23653868-6	2013	The most informative results were obtained with the exon 4 flanking primers and the Cac8I restriction enzyme, which generated a 253 bp product that carries the ACVR1 617G&gt;A mutation, which causes an amino acid substitution of histidine for arginine at position 206 of the glycine-serine (GS) domain, and its mutation results in the dysregulation of bone morphogenetic protein (BMP) signalling that causes FOP.	Histidine	229-238	activin A receptor type 1	Homo sapiens	160-165
23044417-3	2012	Previously, we discovered through a screen of ethylnitrosourea- (ENU-) mutagenized mice that substitution of the latter of these tyrosines with histidine (Y344H) of the murine Sec61alpha protein results in diabetes and hepatic steatosis in mice that is a result of ER stress.	Histidine	144-153	Sec61 alpha 1 subunit (S. cerevisiae)	Mus musculus	176-186
22705350-4	2012	Pull-down assays using GST-beta-catenin and His-Rad6B deletion mutants identified amino acids 131-181 and 50-116, respectively, as necessary for their interaction.	Histidine	44-47	ubiquitin conjugating enzyme E2 B	Homo sapiens	48-53
22919255-8	2012	For XRCC1 Arg280His polymorphism, the overall analysis revealed the significant association between the His/His genotype and the increased risk of HCC (His/His vs Arg/Arg model, OR: 1.96, 95% CI: 1.03-3.75, P = 0.04).	Histidine	16-19	X-ray repair cross complementing 1	Homo sapiens	4-9
22657152-3	2012	Inactivation of ACL by treatment with diethylpyrocarbonate suggested the catalytic role of an active site histidine (i.e., His760), which was proposed to form a phosphohistidine species during catalysis.	Histidine	106-115	ATP citrate lyase	Homo sapiens	16-19
22657152-5	2012	Mutagenesis of His760 to an alanine results in inactivation of the biosynthetic reaction of ACL, in good agreement with the involvement of a catalytic histidine.	Histidine	151-160	ATP citrate lyase	Homo sapiens	92-95
22556417-7	2012	In rP2X2, one of these histidines is replaced by a lysine, and in a background in which zinc potentiation was eliminated, mutation of Lys-197 to histidine converted rP2X2 from low potency to high potency inhibition.	Histidine	23-33	purinergic receptor P2X 2	Rattus norvegicus	165-170
22880226-0	2012	[Functional analysis for dysfibrinogenemias, Toyama and Adachi, which have a mutation of Aalpha16Arg--&gt;His (CGT--&gt;CAT) with aberrant fibrinopeptide A release].	Histidine	106-109	UDP glycosyltransferase 8	Homo sapiens	111-114
22222112-3	2012	The deduced GhAGP31 protein contains the conserved features of non-classical AGPs: a putative signal peptide, N-terminal histidine-rich stretch, middle repetitive proline-rich domain and a cysteine-containing "PAC" domain.	Histidine	121-130	non-classical arabinogalactan protein 31-like	Gossypium hirsutum	12-19
22450164-4	2012	Western blot analysis using an anti-His antibody showed that the His-AtCaN2 fusion protein was not degraded.	Histidine	36-39	Ca(2+)-dependent nuclease family protein	Arabidopsis thaliana	69-75
22417133-2	2012	This histidine-rich elastin-like polypeptide block copolymer self-assembles at 37  C into spherical micelles that are stabilized by Zn(2+) and are disrupted as the pH drops from 7.4 to 6.4.	Histidine	5-14	elastin	Homo sapiens	20-27
22318647-9	2012	l-His &gt; 5"-GMP &gt; 5"-IMP &gt; Ino.	Histidine	0-5	5'-nucleotidase, cytosolic II	Homo sapiens	14-17
22500757-0	2012	pH-responsive titratable inotropic performance of histidine-modified cardiac troponin I.	Histidine	50-59	troponin I3, cardiac type	Homo sapiens	69-87
22500757-2	2012	Studies have shown that a histidine button engineered into cTnI (cTnI A164H) specifically enhances inotropic function in the context of numerous pathophysiological challenges.	Histidine	26-35	troponin I3, cardiac type	Homo sapiens	59-63
22500757-2	2012	Studies have shown that a histidine button engineered into cTnI (cTnI A164H) specifically enhances inotropic function in the context of numerous pathophysiological challenges.	Histidine	26-35	troponin I3, cardiac type	Homo sapiens	65-69
22500757-4	2012	We also assessed the role of histidine-modified cTnI in silico by means of molecular dynamics simulations.	Histidine	29-38	troponin I3, cardiac type	Homo sapiens	48-52
22500757-8	2012	In contrast, simulations of protonated cTnI A164H showed various potential structural configurations, one of which included a salt bridge between His-164 of cTnI and Glu-19 of cTnC.	Histidine	146-149	troponin I3, cardiac type	Homo sapiens	39-43
22500757-8	2012	In contrast, simulations of protonated cTnI A164H showed various potential structural configurations, one of which included a salt bridge between His-164 of cTnI and Glu-19 of cTnC.	Histidine	146-149	troponin I3, cardiac type	Homo sapiens	157-161
22500757-10	2012	These data suggest that differential histidine ionization may be necessary for cTnI A164H to act as a molecular sensor capable of modulating sarcomere performance in response to changes in the cytosolic milieu.	Histidine	37-46	troponin I3, cardiac type	Homo sapiens	79-83
22278351-3	2012	METHODS: [(99m)Tc(CO)(3)(OH(2))(3)](+) was prepared and taken to directly label his(6)-annexin A5.	Histidine	80-83	annexin A5	Mus musculus	87-97
22278351-7	2012	RESULTS: The radiochemical purity of (99m)Tc(I)-his(6)-annexin A5 could attain &gt;=95%.	Histidine	48-51	annexin A5	Mus musculus	55-65
21720759-10	2012	Western blot analysis indicated that His-tagged yak OPN protein expressed in E. coli could be recognized not only by an anti-His-tag antibody but also by an anti-human OPN antibody.	Histidine	37-40	secreted phosphoprotein 1	Bos taurus	52-55
21720759-10	2012	Western blot analysis indicated that His-tagged yak OPN protein expressed in E. coli could be recognized not only by an anti-His-tag antibody but also by an anti-human OPN antibody.	Histidine	37-40	secreted phosphoprotein 1	Bos taurus	168-171
26593369-0	2012	The Protonation States of the Active-Site Histidines in (6-4) Photolyase.	Histidine	42-52	(6-4)-photolyase	Drosophila melanogaster	57-72
22242765-11	2012	Finally, labeling of hZIP4 with maleimide or diethylpyrocarbonate indicates that extracellularly accessible histidine, but not cysteine, residues are required, either directly or indirectly, for cation uptake.	Histidine	108-117	solute carrier family 39 member 4	Homo sapiens	21-26
22242893-0	2012	Role of individual histidines in the pH-dependent global stability of human chloride intracellular channel 1.	Histidine	19-29	chloride intracellular channel 1	Homo sapiens	76-108
22242893-3	2012	We systematically mutated each of the three histidine residues in CLIC1 to an alanine at position 74 and a phenylalanine at positions 185 and 207.	Histidine	44-53	chloride intracellular channel 1	Homo sapiens	66-71
22242893-4	2012	We examined the effect of the histidine-mediated pH dependence on the structure and global stability of CLIC1.	Histidine	30-39	chloride intracellular channel 1	Homo sapiens	104-109
22155078-1	2012	Tyrosyl-DNA phosphodiesterase I (Tdp1) is a member of the phospholipase D superfamily that hydrolyzes 3"-phospho-DNA adducts via two conserved catalytic histidines-one acting as the lead nucleophile and the second acting as a general acid/base.	Histidine	153-163	phospholipase D	Saccharomyces cerevisiae S288C	58-73
22408443-11	2012	The RPL23A gene can be really expressed in E. coli and the RPL23A protein, fusioned with the N-terminally His-tagged protein, gave rise to the accumulation of an expected 22 KDa polypeptide.	Histidine	106-109	60S ribosomal protein L23a	Ailuropoda melanoleuca	4-10
22408443-11	2012	The RPL23A gene can be really expressed in E. coli and the RPL23A protein, fusioned with the N-terminally His-tagged protein, gave rise to the accumulation of an expected 22 KDa polypeptide.	Histidine	106-109	60S ribosomal protein L23a	Ailuropoda melanoleuca	59-65
22837806-5	2012	We then used recombinant His-tagged 14-3-3zeta to pull-down interacting proteins from the mouse hippocampus followed by identification by liquid chromatography-mass spectrometry.	Histidine	25-28	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	Mus musculus	36-46
22350878-3	2012	The protocols include purification of the SUMO E1 enzyme His-Aos1/Uba2, untagged E2 enzyme Ubc9, untagged SUMO, and the RanBP2 E3 ligase fragment IR1 + M. Using these components, we provide step-by-step instructions to set up sumoylation reactions.	Histidine	57-60	SUMO1 activating enzyme subunit 1	Homo sapiens	61-65
21890903-2	2012	This unusual G(-1) residue is the major tRNA(His) identity element, and essential for recognition by the cognate histidyl-tRNA synthetase to allow efficient His-tRNA(His) formation.	Histidine	45-48	histidyl-tRNA synthetase 1	Homo sapiens	113-137
22199132-4	2011	The k(cat)/K(m) values of Nma-Phe-His-Lys(Dnp), Nma-His-Pro-Phe-Lys(Dnp)-Pro, and Hip-His-Leu were 5.12, 1.90, and 0.80 microM(-1) s(-1) for rabbit lung ACE, and 16.0, 7.36, and 0.30 microM(-1) s(-1) for recombinant human (rh)-ACE, respectively.	Histidine	34-37	angiotensin-converting enzyme	Oryctolagus cuniculus	153-156
21785859-6	2011	In addition, cysteine and histidine significantly inhibited the expression of ICAM-1 and production of IL-8 in THP-1 cells and PBMCs.	Histidine	26-35	intercellular adhesion molecule 1	Homo sapiens	78-84
22045708-0	2011	(99)mTc-(CO)(3) His-annexin A5 micro-SPECT demonstrates increased cell death by irinotecan during the vascular normalization window caused by bevacizumab.	Histidine	16-19	annexin A5	Mus musculus	20-30
22045708-6	2011	The apoptosis-detecting radiotracer (99m)Tc-(CO)(3) His-annexin A5 was injected (18.5 MBq) in mice 12, 24, and 48 h after the start of the irinotecan or NaCl treatment, and micro-SPECT was subsequently performed 3.5 h after injection of the radiotracer.	Histidine	52-55	annexin A5	Mus musculus	56-66
21740978-11	2011	(2) The distance between the SXXK-motif Lys-NZ atom and the Lys/His-nitrogen atom of the (K/H)T(S)G-motif was highly conserved, suggesting importance for PBP function, and a possibly conserved role in the catalytic mechanism of the PBPs.	Histidine	64-67	phosphatidylethanolamine binding protein 1	Homo sapiens	154-157
21693190-3	2011	In this study, full length SINV nsP1 was expressed in a soluble form with an N-terminal histidine tag in Escherichia coli and purified to homogeneity.	Histidine	88-97	SH2 domain containing 3A	Homo sapiens	32-36
21746768-3	2011	About one third of these enzymes belong to the secreted PLA(2) (sPLA(2)) family, which comprises low molecular weight, Ca(2+) requiring, secreted enzymes with a His/Asp catalytic dyad.	Histidine	161-164	phospholipase A2, group IB, pancreas	Mus musculus	56-62
21746768-3	2011	About one third of these enzymes belong to the secreted PLA(2) (sPLA(2)) family, which comprises low molecular weight, Ca(2+) requiring, secreted enzymes with a His/Asp catalytic dyad.	Histidine	161-164	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	64-71
21882401-0	2004	3-Cyano-4-[(18)F]fluoro-benzoyl-Ala(SO3H)-Ala(SO3H)-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2 The amphibian bombesin (BBN or BN, a peptide of 14 amino acids) is an analog of human gastrin-releasing peptide (GRP, a peptide of 27 amino acids), which binds to the GRP receptor (GRPR) with high affinity and specificity (1).	Histidine	79-82	gastrin releasing peptide	Homo sapiens	109-117
21882401-0	2004	3-Cyano-4-[(18)F]fluoro-benzoyl-Ala(SO3H)-Ala(SO3H)-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2 The amphibian bombesin (BBN or BN, a peptide of 14 amino acids) is an analog of human gastrin-releasing peptide (GRP, a peptide of 27 amino acids), which binds to the GRP receptor (GRPR) with high affinity and specificity (1).	Histidine	79-82	gastrin releasing peptide	Homo sapiens	181-206
21882401-0	2004	3-Cyano-4-[(18)F]fluoro-benzoyl-Ala(SO3H)-Ala(SO3H)-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2 The amphibian bombesin (BBN or BN, a peptide of 14 amino acids) is an analog of human gastrin-releasing peptide (GRP, a peptide of 27 amino acids), which binds to the GRP receptor (GRPR) with high affinity and specificity (1).	Histidine	79-82	gastrin releasing peptide	Homo sapiens	208-211
21882401-0	2004	3-Cyano-4-[(18)F]fluoro-benzoyl-Ala(SO3H)-Ala(SO3H)-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2 The amphibian bombesin (BBN or BN, a peptide of 14 amino acids) is an analog of human gastrin-releasing peptide (GRP, a peptide of 27 amino acids), which binds to the GRP receptor (GRPR) with high affinity and specificity (1).	Histidine	79-82	gastrin releasing peptide	Homo sapiens	262-265
21505784-6	2011	Replacement of residue Gln(992) in the outer pore with the equivalent residue His(995) in the hTRPM2 channel resulted in a mutant mTRPM2 channel with the pH sensitivity and kinetics of inhibition of the wild-type hTRPM2 channel.	Histidine	78-81	transient receptor potential cation channel subfamily M member 2	Homo sapiens	94-100
21505784-6	2011	Replacement of residue Gln(992) in the outer pore with the equivalent residue His(995) in the hTRPM2 channel resulted in a mutant mTRPM2 channel with the pH sensitivity and kinetics of inhibition of the wild-type hTRPM2 channel.	Histidine	78-81	transient receptor potential cation channel, subfamily M, member 2	Mus musculus	130-136
21505784-6	2011	Replacement of residue Gln(992) in the outer pore with the equivalent residue His(995) in the hTRPM2 channel resulted in a mutant mTRPM2 channel with the pH sensitivity and kinetics of inhibition of the wild-type hTRPM2 channel.	Histidine	78-81	transient receptor potential cation channel subfamily M member 2	Homo sapiens	213-219
21505784-9	2011	Taken together, our results suggest a crucial role of residue His(995)/Gln(992) in the outer pore of TRPM2 channels in determining species-dependent effects of extracellular acidic pH.	Histidine	62-65	transient receptor potential cation channel subfamily M member 2	Homo sapiens	101-106
21666675-2	2011	Most missense mutations in the OCRL ASH-RhoGAP domain that are found in affected individuals abolish interactions with the endocytic adaptors APPL1 and Ses (both Ses1 and Ses2), which bind OCRL through a short phenylalanine and histidine (F&amp;H) motif.	Histidine	228-237	Rho GTPase activating protein 1	Homo sapiens	40-46
21666675-2	2011	Most missense mutations in the OCRL ASH-RhoGAP domain that are found in affected individuals abolish interactions with the endocytic adaptors APPL1 and Ses (both Ses1 and Ses2), which bind OCRL through a short phenylalanine and histidine (F&amp;H) motif.	Histidine	228-237	secernin 2	Homo sapiens	171-175
21390047-6	2011	Importantly, adjusted Cox regression analysis not only confirmed ERCC5 1104 His/His as an independent prognostic factor (multivariate HR=4.5; P&lt;0.001), but also revealed the significant impact of ERCC2 (XPD) 751 Gln/Gln on prognosis, with a 2.2-fold increased HR compared with ERCC2 751 Lys/Lys (P=0.009).	Histidine	76-79	ERCC excision repair 5, endonuclease	Homo sapiens	65-70
21390047-6	2011	Importantly, adjusted Cox regression analysis not only confirmed ERCC5 1104 His/His as an independent prognostic factor (multivariate HR=4.5; P&lt;0.001), but also revealed the significant impact of ERCC2 (XPD) 751 Gln/Gln on prognosis, with a 2.2-fold increased HR compared with ERCC2 751 Lys/Lys (P=0.009).	Histidine	80-83	ERCC excision repair 5, endonuclease	Homo sapiens	65-70
21296058-9	2011	Molecular modeling of BADH revealed that the oxidized methionine and histidine residues are near the NAD(+) binding site.	Histidine	69-78	aldehyde dehydrogenase 7 family member A1	Homo sapiens	22-26
21530495-0	2011	A conserved histidine in human DNLZ/HEP is required for stimulation of HSPA9 ATPase activity.	Histidine	12-21	DNL-type zinc finger	Homo sapiens	31-35
21530495-6	2011	These findings implicate a conserved histidine as critical for DNLZ regulation of mitochondrial HSPA9 catalytic activity.	Histidine	37-46	DNL-type zinc finger	Homo sapiens	63-67
21502511-2	2011	Aprataxin exhibits homology to the histidine triad superfamily of nucleotide hydrolases and transferases and removes 5"-adenylate groups from DNA that arise from aborted ligation reactions.	Histidine	35-44	aprataxin	Homo sapiens	0-9
21563331-0	2004	(68)Ga-DOTA-4-amino-1-carboxymethyl-piperidine-D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2 The amphibian bombesin (BBN or BN, a peptide of 14 amino acids) is an analog of human gastrin-releasing peptide (GRP, a peptide of 27 amino acids) that binds to GRP receptor (GRPR) with high affinity and specificity (1).	Histidine	73-76	gastrin releasing peptide	Homo sapiens	103-111
21563331-0	2004	(68)Ga-DOTA-4-amino-1-carboxymethyl-piperidine-D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2 The amphibian bombesin (BBN or BN, a peptide of 14 amino acids) is an analog of human gastrin-releasing peptide (GRP, a peptide of 27 amino acids) that binds to GRP receptor (GRPR) with high affinity and specificity (1).	Histidine	73-76	gastrin releasing peptide	Homo sapiens	175-200
21563331-0	2004	(68)Ga-DOTA-4-amino-1-carboxymethyl-piperidine-D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2 The amphibian bombesin (BBN or BN, a peptide of 14 amino acids) is an analog of human gastrin-releasing peptide (GRP, a peptide of 27 amino acids) that binds to GRP receptor (GRPR) with high affinity and specificity (1).	Histidine	73-76	gastrin releasing peptide	Homo sapiens	202-205
21277849-8	2011	Increased lysosomal histidine, in the absence of SLC15A4, appears to negatively regulate Toll-like receptor 9 function by inhibiting the proteolytic activities of cathepsins B and L. SLC15A4(-/-) mice also had a severe defect in NOD1-dependent cytokine production, indicating that SLC15A4 functions as a transporter of the NOD1 ligand.	Histidine	20-29	toll-like receptor 9	Mus musculus	89-109
21228277-3	2011	The C-terminal catalytic domain is similar to UfSP1 with Cys(294), Asp(418), His(420), Tyr(282), and a regulatory loop participating in catalysis.	Histidine	77-80	UFM1-specific peptidase 1	Mus musculus	46-51
21332165-2	2011	With respect to other globins similar to myoglobin, Ngb displays some peculiarities as the topological reorganization of the internal cavities coupled to the sliding of the heme, or the binding of the endogenous distal histidine to the heme in the absence of an exogenous ligand.	Histidine	219-228	neuroglobin	Homo sapiens	52-55
21156191-2	2011	The new allele was identical to HLA-G*01:06 at exons 2, 3, and 4 with the exception of a base pair substitution at codon 169 (CAC   CGC) resulting in a coding change from histidine to arginine and codon 171 (TAC   CAC), resulting in turn in a coding change from tyrosine to histidine.	Histidine	171-180	major histocompatibility complex, class I, G	Homo sapiens	32-37
21156191-2	2011	The new allele was identical to HLA-G*01:06 at exons 2, 3, and 4 with the exception of a base pair substitution at codon 169 (CAC   CGC) resulting in a coding change from histidine to arginine and codon 171 (TAC   CAC), resulting in turn in a coding change from tyrosine to histidine.	Histidine	274-283	major histocompatibility complex, class I, G	Homo sapiens	32-37
20083497-2	2011	The histidine (position 41) in the conserved sequence TAAHC is mutated to serine and this sequence (TAASC) plays a crucial role when HBP binds to monocytes.	Histidine	4-13	azurocidin 1	Homo sapiens	133-136
21290627-0	2004	3-Cyano-4-[(18)F]fluoro-benzoyl-Ala(SO3H)-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2 3-Cyano-4-[(18)F]fluoro-benzoyl-Ala(SO3H)-Ava-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2, abbreviated as [(18)F]7b, is a bombesin (BN)-based (18)F-labeled peptide synthesized by Mu et al.	Histidine	154-157	gastrin releasing peptide	Homo sapiens	202-210
20978135-0	2011	Histidine 103 in Fra2 is an iron-sulfur cluster ligand in the [2Fe-2S] Fra2-Grx3 complex and is required for in vivo iron signaling in yeast.	Histidine	0-9	Bol2p	Saccharomyces cerevisiae S288C	17-21
20978135-0	2011	Histidine 103 in Fra2 is an iron-sulfur cluster ligand in the [2Fe-2S] Fra2-Grx3 complex and is required for in vivo iron signaling in yeast.	Histidine	0-9	Bol2p	Saccharomyces cerevisiae S288C	71-75
20978135-0	2011	Histidine 103 in Fra2 is an iron-sulfur cluster ligand in the [2Fe-2S] Fra2-Grx3 complex and is required for in vivo iron signaling in yeast.	Histidine	0-9	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	76-80
21170982-7	2011	To deplete the antigen from the eluted sample, IMAC spin columns were utilized to bind the N-terminal His-tag of the antigens.	Histidine	102-105	C-C motif chemokine ligand 26	Homo sapiens	47-51
21325825-1	2011	The glutamine transporter SNAT3 (SLC38A3), which also transports asparagine and histidine, exchanges sodium for protons, and displays a non-stoichiometrical conductance, which is suppressed by the catalytic activity of carbonic anhydrase II (CAII).	Histidine	80-89	solute carrier family 38, member 3	Rattus norvegicus	26-31
21325825-1	2011	The glutamine transporter SNAT3 (SLC38A3), which also transports asparagine and histidine, exchanges sodium for protons, and displays a non-stoichiometrical conductance, which is suppressed by the catalytic activity of carbonic anhydrase II (CAII).	Histidine	80-89	solute carrier family 38, member 3	Rattus norvegicus	33-40
20666624-3	2011	We observed that patients with the ITGAM His/His and Arg/His genotypes displayed a 1.811-fold increased risk of SLE incidence (95% confidence intervals [95% CI] = 1.171-2.802, p = 0.0089).	Histidine	41-44	integrin subunit alpha M	Homo sapiens	35-40
20666624-3	2011	We observed that patients with the ITGAM His/His and Arg/His genotypes displayed a 1.811-fold increased risk of SLE incidence (95% confidence intervals [95% CI] = 1.171-2.802, p = 0.0089).	Histidine	45-48	integrin subunit alpha M	Homo sapiens	35-40
20666624-3	2011	We observed that patients with the ITGAM His/His and Arg/His genotypes displayed a 1.811-fold increased risk of SLE incidence (95% confidence intervals [95% CI] = 1.171-2.802, p = 0.0089).	Histidine	45-48	integrin subunit alpha M	Homo sapiens	35-40
20666624-4	2011	Odds ratio (OR) for the homozygous ITGAM His/His genotype was 7.333 (95% CI = 0.8119-66.241, p = 0.0576).	Histidine	41-44	integrin subunit alpha M	Homo sapiens	35-40
20666624-4	2011	Odds ratio (OR) for the homozygous ITGAM His/His genotype was 7.333 (95% CI = 0.8119-66.241, p = 0.0576).	Histidine	45-48	integrin subunit alpha M	Homo sapiens	35-40
20666624-6	2011	There was an association of the ITGAM His/His and Arg/His genotypes with the occurrence of arthritis OR = 3.486 (95% CI = 1.619-7.508, p = 0.0015).	Histidine	38-41	integrin subunit alpha M	Homo sapiens	32-37
20666624-6	2011	There was an association of the ITGAM His/His and Arg/His genotypes with the occurrence of arthritis OR = 3.486 (95% CI = 1.619-7.508, p = 0.0015).	Histidine	42-45	integrin subunit alpha M	Homo sapiens	32-37
20666624-6	2011	There was an association of the ITGAM His/His and Arg/His genotypes with the occurrence of arthritis OR = 3.486 (95% CI = 1.619-7.508, p = 0.0015).	Histidine	42-45	integrin subunit alpha M	Homo sapiens	32-37
20666624-7	2011	We also observed an association between the ITGAM His/His and Arg/His genotypes and renal symptoms in the course of SLE OR = 2.975 (95% CI = 1.478-5.988; p = 0.0023).	Histidine	50-53	integrin subunit alpha M	Homo sapiens	44-49
20666624-7	2011	We also observed an association between the ITGAM His/His and Arg/His genotypes and renal symptoms in the course of SLE OR = 2.975 (95% CI = 1.478-5.988; p = 0.0023).	Histidine	54-57	integrin subunit alpha M	Homo sapiens	44-49
20666624-7	2011	We also observed an association between the ITGAM His/His and Arg/His genotypes and renal symptoms in the course of SLE OR = 2.975 (95% CI = 1.478-5.988; p = 0.0023).	Histidine	54-57	integrin subunit alpha M	Homo sapiens	44-49
20966079-2	2010	The severe metal ion substrate inhibition observed during in vitro studies of the purified enzyme is almost completely eliminated by mutation of an active site histidine residue (His-287, murine ferrochelatase numbering) to leucine and reduced over 2 orders of magnitude by mutation of a nearby conserved phenylalanine residue (Phe-283) to leucine.	Histidine	160-169	ferrochelatase	Mus musculus	195-209
20966079-2	2010	The severe metal ion substrate inhibition observed during in vitro studies of the purified enzyme is almost completely eliminated by mutation of an active site histidine residue (His-287, murine ferrochelatase numbering) to leucine and reduced over 2 orders of magnitude by mutation of a nearby conserved phenylalanine residue (Phe-283) to leucine.	Histidine	179-182	ferrochelatase	Mus musculus	195-209
21028829-2	2010	The shortest PTH analogue displaying nanomolar potency is the undecapeptide H-Aib-Val-Aib-Glu-Ile-Gln-Leu-Nle-His-Gln-Har-NH(2) that contains two helix-stabilizing residues (Aib(1,3)).	Histidine	110-113	ANIB1	Homo sapiens	78-81
21028829-2	2010	The shortest PTH analogue displaying nanomolar potency is the undecapeptide H-Aib-Val-Aib-Glu-Ile-Gln-Leu-Nle-His-Gln-Har-NH(2) that contains two helix-stabilizing residues (Aib(1,3)).	Histidine	110-113	ANIB1	Homo sapiens	86-89
21028829-2	2010	The shortest PTH analogue displaying nanomolar potency is the undecapeptide H-Aib-Val-Aib-Glu-Ile-Gln-Leu-Nle-His-Gln-Har-NH(2) that contains two helix-stabilizing residues (Aib(1,3)).	Histidine	110-113	ANIB1	Homo sapiens	86-89
21081096-3	2010	However, subtle residue motions can be distinguished, specifically of His(329) and Asp(330) to assemble in pol mu"s active site, and of Gln(440) and Glu(443) to help accommodate the incoming nucleotide.	Histidine	70-73	DNA polymerase mu	Homo sapiens	107-113
20977193-3	2010	The active site of this superfamily of enzymes includes a Ser1/Ser2(Tyr)/Lys1(His)/Lys2 tetrad in which Ser1 is a nucleophilic catalyst that becomes acylated in the formation of an acyl-enzyme intermediate.	Histidine	78-81	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	Homo sapiens	83-87
20084469-5	2010	DT-SCF gene coding for 1-387 amino acids of diphtheria toxin, His-Ala linker, 2-141 amino acids of SCF was cloned into expression vector with C terminal His tag.	Histidine	62-65	KIT ligand	Homo sapiens	3-6
20084469-5	2010	DT-SCF gene coding for 1-387 amino acids of diphtheria toxin, His-Ala linker, 2-141 amino acids of SCF was cloned into expression vector with C terminal His tag.	Histidine	153-156	KIT ligand	Homo sapiens	3-6
20835484-1	2010	Pb-binding TAR-1 peptides (Ile-Ser-Leu-Leu-His-Ser-Thr) were covalently conjugated on a bolaamphiphile peptide nanotube substrate and the precursors of PbSe were incubated at room temperature.	Histidine	43-46	trace amine associated receptor 1	Homo sapiens	11-16
20690616-3	2010	We have found that a small four-histidine peptide, NAHis04, potently inhibits the Abeta-induced calcium channel currents in artificial lipid membranes.	Histidine	32-41	amyloid beta precursor protein	Rattus norvegicus	82-87
20690616-9	2010	We have modeled how up to four NAHis04 peptides may block these types of pores by binding to side chains of Abeta residues Glu 11, His 13, and His 14.	Histidine	33-36	amyloid beta precursor protein	Rattus norvegicus	108-113
20690616-9	2010	We have modeled how up to four NAHis04 peptides may block these types of pores by binding to side chains of Abeta residues Glu 11, His 13, and His 14.	Histidine	131-134	amyloid beta precursor protein	Rattus norvegicus	108-113
20806985-4	2010	The hypothesis is based on published in vitro observations that the human dopamine transporter contains a high-affinity zinc binding site (His-193, His-375, Glu-396) on its extracellular face that modulates transporter function, and in vivo studies suggesting that response to stimulants is reduced in zinc-deficient ADHD patients.	Histidine	139-142	solute carrier family 6 member 3	Homo sapiens	74-94
20806985-4	2010	The hypothesis is based on published in vitro observations that the human dopamine transporter contains a high-affinity zinc binding site (His-193, His-375, Glu-396) on its extracellular face that modulates transporter function, and in vivo studies suggesting that response to stimulants is reduced in zinc-deficient ADHD patients.	Histidine	148-151	solute carrier family 6 member 3	Homo sapiens	74-94
20629116-1	2010	A series of peptide-peptoid hybrids, containing N-substituted glycines, were synthesized based on the H-Aib-Val-Aib-Glu-Ile-Gln-Leu-Nle-His-Gln-Har-NH(2) (Har = Homoarginine) as the parent parathyroid hormone (1-11) analog.	Histidine	136-139	ANIB1	Homo sapiens	104-107
20629116-1	2010	A series of peptide-peptoid hybrids, containing N-substituted glycines, were synthesized based on the H-Aib-Val-Aib-Glu-Ile-Gln-Leu-Nle-His-Gln-Har-NH(2) (Har = Homoarginine) as the parent parathyroid hormone (1-11) analog.	Histidine	136-139	ANIB1	Homo sapiens	112-115
20600126-2	2010	Peptide agonists of the MC4R are characterized by the conserved sequence His(6)-Phe(7)-Arg(8)-Trp(9), which is crucial for their interaction with the receptor.	Histidine	73-76	melanocortin 4 receptor	Homo sapiens	24-28
20538074-4	2010	On the other hand, recent whole-heart epicardial and endocardial optical mapping data demonstrate that ventricular arrhythmias in the RyR2(R4496C) mouse model of catecholaminergic polymorphic ventricular tachycardia (CPVT) originate in the His-Purkinje system, suggesting that Purkinje cells, and not ventricular myocytes, may be the cellular source of arrhythmogenic activity.	Histidine	240-243	ryanodine receptor 2, cardiac	Mus musculus	134-138
20538074-11	2010	CONCLUSION: These results demonstrate that focally activated arrhythmias originate in the specialized electrical conducting cells of the His-Purkinje system in the RyR2(R4496C) mouse model of CPVT.	Histidine	137-140	ryanodine receptor 2, cardiac	Mus musculus	164-168
20361220-3	2010	Previous studies suggested that the first step of the dioxygenase reaction involves the deprotonation of the indoleamine group of the substrate by an evolutionarily conserved distal histidine residue in TDO and the heme-bound dioxygen in IDO.	Histidine	182-191	tryptophan 2,3-dioxygenase	Homo sapiens	203-206
20361220-5	2010	Our data suggest that the deprotonation of the indoleamine group of the substrate by either histidine in TDO or heme-bound dioxygen in IDO is not energetically favorable.	Histidine	92-101	tryptophan 2,3-dioxygenase	Homo sapiens	105-108
20544958-1	2010	The C-terminal three-Cys(2)His(2) zinc-finger domain (TZD) of mouse testis zinc-finger protein binds to the 5"-TGTACAGTGT-3" at the Aie1 (aurora-C) promoter with high specificity.	Histidine	27-30	aurora kinase C	Mus musculus	132-136
20423961-6	2010	This study provides evidence that a His to Ala substitution within mammalian cardiac TnI (cTnI) reduced the thermodynamic potential at the interface between cTnI and cardiac TnC (cTnC) in the calcium-saturated state by disrupting a strong intermolecular electrostatic interaction.	Histidine	36-39	troponin I3, cardiac type	Homo sapiens	77-88
20423961-6	2010	This study provides evidence that a His to Ala substitution within mammalian cardiac TnI (cTnI) reduced the thermodynamic potential at the interface between cTnI and cardiac TnC (cTnC) in the calcium-saturated state by disrupting a strong intermolecular electrostatic interaction.	Histidine	36-39	troponin I3, cardiac type	Homo sapiens	90-94
20423961-6	2010	This study provides evidence that a His to Ala substitution within mammalian cardiac TnI (cTnI) reduced the thermodynamic potential at the interface between cTnI and cardiac TnC (cTnC) in the calcium-saturated state by disrupting a strong intermolecular electrostatic interaction.	Histidine	36-39	troponin I3, cardiac type	Homo sapiens	157-161
20423961-6	2010	This study provides evidence that a His to Ala substitution within mammalian cardiac TnI (cTnI) reduced the thermodynamic potential at the interface between cTnI and cardiac TnC (cTnC) in the calcium-saturated state by disrupting a strong intermolecular electrostatic interaction.	Histidine	36-39	tenascin C	Homo sapiens	174-177
20463099-7	2010	RESULTS: DNA sequence analysis revealed an A to C transversion at codon 502 of GCMB, which altered the wild-type asparagine (Asn) to histidine (His).	Histidine	133-142	glial cells missing transcription factor 2	Homo sapiens	79-83
20463099-7	2010	RESULTS: DNA sequence analysis revealed an A to C transversion at codon 502 of GCMB, which altered the wild-type asparagine (Asn) to histidine (His).	Histidine	144-147	glial cells missing transcription factor 2	Homo sapiens	79-83
20692404-11	2010	CONCLUSION: Three new enzymes (MTF, NB1, and CI) may enable us to obtain higher islet yields than with HI.	Histidine	103-105	metallothionein 1L, pseudogene	Homo sapiens	31-34
20598110-2	2010	Comparison of the substrate-binding site of PRCP with that of its family partner, dipeptidyl dipeptidase 7 (DPP7), helps to explain the different enzymatic activities of these structurally similar proteins, and also reveals a novel apparent charge-relay system in PRCP involving the active-site catalytic histidine.	Histidine	305-314	prolylcarboxypeptidase	Homo sapiens	44-48
20598110-2	2010	Comparison of the substrate-binding site of PRCP with that of its family partner, dipeptidyl dipeptidase 7 (DPP7), helps to explain the different enzymatic activities of these structurally similar proteins, and also reveals a novel apparent charge-relay system in PRCP involving the active-site catalytic histidine.	Histidine	305-314	prolylcarboxypeptidase	Homo sapiens	264-268
20421979-4	2010	METHODOLOGY/PRINCIPAL FINDINGS: We produced a transgenic mouse line which expresses His-tagged IZUMO1 in the Izumo1(-/-) genetic background.	Histidine	84-87	izumo sperm-egg fusion 1	Mus musculus	95-101
20421979-4	2010	METHODOLOGY/PRINCIPAL FINDINGS: We produced a transgenic mouse line which expresses His-tagged IZUMO1 in the Izumo1(-/-) genetic background.	Histidine	84-87	izumo sperm-egg fusion 1	Mus musculus	109-115
20421979-5	2010	After solubilization of sperm membranes, we purified His-tagged IZUMO1 using anti-His affinity chromatography and found a protein that interacts with IZUMO1.	Histidine	53-56	izumo sperm-egg fusion 1	Mus musculus	64-70
20421979-5	2010	After solubilization of sperm membranes, we purified His-tagged IZUMO1 using anti-His affinity chromatography and found a protein that interacts with IZUMO1.	Histidine	53-56	izumo sperm-egg fusion 1	Mus musculus	150-156
20421979-5	2010	After solubilization of sperm membranes, we purified His-tagged IZUMO1 using anti-His affinity chromatography and found a protein that interacts with IZUMO1.	Histidine	82-85	izumo sperm-egg fusion 1	Mus musculus	64-70
20421979-5	2010	After solubilization of sperm membranes, we purified His-tagged IZUMO1 using anti-His affinity chromatography and found a protein that interacts with IZUMO1.	Histidine	82-85	izumo sperm-egg fusion 1	Mus musculus	150-156
19723023-8	2010	With detraining in the HI group, CD34+ cells declined 44 %, and the percentage change in CD34+/VEGFR2+ cells was positively correlated with the change in FBF response to reactive hyperaemia.	Histidine	23-25	kinase insert domain receptor	Homo sapiens	95-101
20047315-8	2010	The electronic properties of the hemes in the reduced state of TDO change significantly upon L-Trp addition, which is attributed to a change in the protonation state of the proximal histidine to the hemes.	Histidine	182-191	tryptophan 2,3-dioxygenase	Homo sapiens	63-66
20047315-13	2010	This work presents a new description of the heme interactions with the protein, and with the proximal His, which must be considered during the general interpretation of physical data as it relates to kinetics, mechanism, and function of TDO.	Histidine	102-105	tryptophan 2,3-dioxygenase	Homo sapiens	237-240
20798512-4	2010	Phosphorylation of GCN2 kinase and its substrate eIF2alpha was induced by histidine deprivation.	Histidine	74-83	eukaryotic translation initiation factor 2 alpha kinase 4	Homo sapiens	19-23
20798512-4	2010	Phosphorylation of GCN2 kinase and its substrate eIF2alpha was induced by histidine deprivation.	Histidine	74-83	eukaryotic translation initiation factor 2A	Homo sapiens	49-58
20798512-8	2010	Histidine deprivation as well as activation of GCN2 by treatment with tRNA, caused an increase in LX-2 cell viability, suggesting amino acid restriction to present a protective effect in HSC which is mediated by GCN2 activation.	Histidine	0-9	eukaryotic translation initiation factor 2 alpha kinase 4	Homo sapiens	212-216
21077763-0	2010	Hb East Timor [beta80(EF4)Asn His, AAC&gt;CAC (HBB c.241A&gt;C)], a variant hemoglobin associated with normal hematology.	Histidine	30-33	GTP binding elongation factor GUF1	Homo sapiens	22-25
21077763-3	2010	The variant is due to a missense mutation at amino acid codon 80 (AAC&gt;CAC) which results in the substitution of histidine for asparagine.	Histidine	115-124	carbonic anhydrase 2	Homo sapiens	73-76
19801650-4	2009	The MK structure-function results demonstrate that the His-305, Leu-404, Leu-414, and Val-418 mutations, which increase the free volume of the hVDR ligand binding pocket, significantly enhance MK antagonist potency.	Histidine	55-58	vitamin D receptor	Homo sapiens	143-147
19954242-2	2009	Among them, the nonsymbiotic hemoglobin AHb1 from Arabidopsis thaliana deserves particular attention, as it combines an extremely high oxygen affinity with an internal hexacoordination of the distal histidine HisE7 to the heme iron in the absence of exogenous ligands.	Histidine	199-208	hemoglobin 1	Arabidopsis thaliana	40-44
19786305-5	2009	Both peptides show a synchrotron radiation (SR) CD-pattern resembling to that of the polyproline II structure, similarly to that of the His-Pro-rich domain of the HRG protein.	Histidine	136-139	histidine rich glycoprotein	Homo sapiens	163-166
19778897-5	2009	We found that N-terminal His tags directly influence the interaction between EB1 and MTs, significantly increasing both affinity and activity, and that small amounts of His-tagged proteins act synergistically with larger amounts of untagged proteins.	Histidine	25-28	microtubule associated protein RP/EB family member 1	Homo sapiens	77-80
20641306-4	2004	GRP and BN share an identical C-terminal region (-Trp-Ala-Val-Gly-His-Leu-Met-NH2), which is necessary for receptor binding and signal transduction (5, 6).	Histidine	66-69	gastrin releasing peptide	Homo sapiens	0-3
19546227-5	2009	Strains were starved for histidine, leucine, or tryptophan and shown to rapidly induce Gcn2p phosphorylation of eIF2.	Histidine	25-34	serine/threonine-protein kinase GCN2	Saccharomyces cerevisiae S288C	87-92
19553567-2	2009	Homology models constructed on the basis of the experimental structures of Escherichia coli AmtB and Nitrosomonas europaea Rh50 indicated a channel structure for human RhA (RhAG), RhB (RhBG), and RhC (RhCG) glycoproteins in which external and internal vestibules are linked by a pore containing two strictly conserved histidines.	Histidine	318-328	Rh family B glycoprotein	Homo sapiens	180-183
19553567-2	2009	Homology models constructed on the basis of the experimental structures of Escherichia coli AmtB and Nitrosomonas europaea Rh50 indicated a channel structure for human RhA (RhAG), RhB (RhBG), and RhC (RhCG) glycoproteins in which external and internal vestibules are linked by a pore containing two strictly conserved histidines.	Histidine	318-328	Rh family B glycoprotein	Homo sapiens	185-189
19500832-2	2009	Alpha-elastin was chemically crosslinked with hexamethylene diisocyanate that can react with various functional groups in elastin such as lysine, cysteine, and histidine.	Histidine	160-169	elastin	Homo sapiens	6-13
19500832-2	2009	Alpha-elastin was chemically crosslinked with hexamethylene diisocyanate that can react with various functional groups in elastin such as lysine, cysteine, and histidine.	Histidine	160-169	elastin	Homo sapiens	122-129
19406162-5	2009	In this study, one recombinant baculovirus BacSC-NS3 expressing histidine-tagged NS3 with the transmembrane domain (TM) and cytoplasmic domain (CTD) derived from baculovirus envelope protein gp64 of baculovirus was constructed.	Histidine	64-73	KRAS proto-oncogene, GTPase	Homo sapiens	49-52
19406162-5	2009	In this study, one recombinant baculovirus BacSC-NS3 expressing histidine-tagged NS3 with the transmembrane domain (TM) and cytoplasmic domain (CTD) derived from baculovirus envelope protein gp64 of baculovirus was constructed.	Histidine	64-73	KRAS proto-oncogene, GTPase	Homo sapiens	81-84
19396588-0	2009	One-step column purification of herpes simplex virus 1 helicase-primase subcomplex using C-terminally his-tagged UL5 subunit.	Histidine	102-105	helicase-primase helicase subunit	Human alphaherpesvirus 1	113-116
19396588-2	2009	In order to bind the enzyme complex consisting of UL5 and UL52 gene functions to the affinity column, the C-terminus of the UL5 gene of HSV-1 strain ANG was fused in-frame with a sequence encoding six histidines, resulting in a His6-tagged DNA helicase (UL5his) when expressed via recombinant baculovirus.	Histidine	201-211	helicase-primase helicase subunit	Human alphaherpesvirus 1	50-53
19396588-2	2009	In order to bind the enzyme complex consisting of UL5 and UL52 gene functions to the affinity column, the C-terminus of the UL5 gene of HSV-1 strain ANG was fused in-frame with a sequence encoding six histidines, resulting in a His6-tagged DNA helicase (UL5his) when expressed via recombinant baculovirus.	Histidine	201-211	helicase-primase helicase subunit	Human alphaherpesvirus 1	58-61
19590015-3	2009	Mutation of an active site His-105 in PGAM5 abolished phosphatase activity with ASK1 and phospho-Thr peptides as substrates.	Histidine	27-30	Serine/threonine-protein phosphatase Pgam5, mitochondrial	Caenorhabditis elegans	38-43
19662275-3	2009	Exchange of the Cys-S-S-Cys bridge by the His-Cu(II)-His motif is very promising, because the resulting complexes retain topological similarity to the native S-S bridged AVP and OXT at pH values corresponding to the physiological pH.	Histidine	42-45	oxytocin/neurophysin I prepropeptide	Homo sapiens	178-181
19662275-3	2009	Exchange of the Cys-S-S-Cys bridge by the His-Cu(II)-His motif is very promising, because the resulting complexes retain topological similarity to the native S-S bridged AVP and OXT at pH values corresponding to the physiological pH.	Histidine	53-56	oxytocin/neurophysin I prepropeptide	Homo sapiens	178-181
19504439-5	2009	RESULTS: Alignment of the GATA-4 amino acid sequence indicated that the histidine residue at position 436 was conserved, and H436Y mutation in the GATA-4 gene is expected to affect its protein function.	Histidine	72-81	GATA binding protein 4	Homo sapiens	26-32
19246456-5	2009	Substitution of the three polar amino acid residues (His(46), Gln(50), and Gln(53)) within this motif with alanine abolishes the inhibitory effect of Angptl4 on LPL in vitro and also abrogates the ability of Angptl4 to elevate plasma triglyceride levels in mice.	Histidine	53-56	lipoprotein lipase	Mus musculus	161-164
19248787-7	2009	Intracardiac evaluation of the atria-His (AH) and His-ventricle (HV) intervals representing supra and infra-Hisian conduction yielded significant acceleration of supra-Hisian conductivity in Cx30.2(LacZ/LacZ) (AH: 28.2+/-4.3 ms) and prolongation of infra-Hisian conduction in Cx40(-/-) mice (HV: 13.7+/-2.6 ms).	Histidine	37-40	gap junction protein, delta 3	Mus musculus	191-197
18831041-10	2009	The amino acids at CD4 and E14 differ between bovine and the fish Hbs and have the potential to modulate oxidative degradation by altering the orientation of the distal histidine and the stability of the E-helix.	Histidine	169-178	CD4 molecule	Bos taurus	19-22
19052917-9	2009	On the basis of the presence of the several endogenous His residues and glycosylation moieties in CXCR1 we fractionated the detergent-solubilized plasma membranes by employing Ni- and Concanavalin A-based chromatography.	Histidine	55-58	C-X-C motif chemokine receptor 1	Homo sapiens	98-103
19202543-5	2009	Zinc activates TRPA1 through a unique mechanism that requires zinc influx through TRPA1 channels and subsequent activation via specific intracellular cysteine and histidine residues.	Histidine	163-172	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	15-20
19202543-5	2009	Zinc activates TRPA1 through a unique mechanism that requires zinc influx through TRPA1 channels and subsequent activation via specific intracellular cysteine and histidine residues.	Histidine	163-172	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	82-87
19074135-0	2009	Mutation of histidine 105 in the T1 domain of the potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4.	Histidine	12-21	potassium voltage-gated channel subfamily B member 1	Homo sapiens	68-73
19074135-3	2009	In Kv6.x channels the histidine residue of the zinc ion-coordinating C3H1 motif of Kv2.1 is replaced by arginine or valine.	Histidine	22-31	potassium voltage-gated channel subfamily B member 1	Homo sapiens	83-88
19074135-4	2009	Using a yeast two-hybrid assay, we found that substitution of the corresponding histidine 105 in Kv2.1 by valine (H105V) or arginine (H105R) disrupted the interaction of the T1 domain of Kv2.1 with the T1 domains of both Kv6.3 and Kv6.4, whereas interaction of the T1 domain of Kv2.1 with itself was unaffected by this mutation.	Histidine	80-89	potassium voltage-gated channel subfamily B member 1	Homo sapiens	97-102
19074135-4	2009	Using a yeast two-hybrid assay, we found that substitution of the corresponding histidine 105 in Kv2.1 by valine (H105V) or arginine (H105R) disrupted the interaction of the T1 domain of Kv2.1 with the T1 domains of both Kv6.3 and Kv6.4, whereas interaction of the T1 domain of Kv2.1 with itself was unaffected by this mutation.	Histidine	80-89	potassium voltage-gated channel subfamily B member 1	Homo sapiens	187-192
19074135-4	2009	Using a yeast two-hybrid assay, we found that substitution of the corresponding histidine 105 in Kv2.1 by valine (H105V) or arginine (H105R) disrupted the interaction of the T1 domain of Kv2.1 with the T1 domains of both Kv6.3 and Kv6.4, whereas interaction of the T1 domain of Kv2.1 with itself was unaffected by this mutation.	Histidine	80-89	potassium voltage-gated channel subfamily B member 1	Homo sapiens	187-192
19074135-10	2009	Our results suggest that His-105 in the T1 domain of Kv2.1 is required for functional heteromerization with members of the Kv6 subfamily.	Histidine	25-28	potassium voltage-gated channel subfamily B member 1	Homo sapiens	53-58
19164517-9	2009	Mutating this residue to histidine induced 2-APB sensitivity of chicken TRPV3 to levels comparable for other TRPV3 orthologs.	Histidine	25-34	transient receptor potential cation channel subfamily V member 3	Gallus gallus	72-77
19164517-9	2009	Mutating this residue to histidine induced 2-APB sensitivity of chicken TRPV3 to levels comparable for other TRPV3 orthologs.	Histidine	25-34	transient receptor potential cation channel subfamily V member 3	Gallus gallus	109-114
19120358-2	2009	An N-terminal-tat and C-terminal histidine-tagged version of hoxb4 (T-hoxb4-H) showed the highest activity in expanding colony forming cells (CFCs) and long-term culture-initiating cells (LTC-ICs) when used at 50 nmol/l concentration in cell culture.	Histidine	33-42	homeobox B4	Homo sapiens	61-66
19120358-2	2009	An N-terminal-tat and C-terminal histidine-tagged version of hoxb4 (T-hoxb4-H) showed the highest activity in expanding colony forming cells (CFCs) and long-term culture-initiating cells (LTC-ICs) when used at 50 nmol/l concentration in cell culture.	Histidine	33-42	homeobox B4	Homo sapiens	70-75
19088994-4	2009	We study this situation in Human Carbonic Anhydrase II (HCA II) in which one of the three histidines bound to zinc (His119) interacts also with a glutamate residue (Glu117).	Histidine	90-100	carbonic anhydrase 2	Homo sapiens	33-54
19117199-10	2009	Kinetic data of the present study supported our recently published findings [using single step-solid phase radioimmunoassay (SS-SPRIA)] that the core region of a conformation-specific epitope of hCGbeta consists of Arg (94, 95) and Asp (99) while a Lys (104) and a His (106) are in proximity to the core epitopic region.	Histidine	265-268	chorionic gonadotropin subunit beta 3	Homo sapiens	195-202
19107418-3	2009	Two alternative procedures are described for the E1 enzyme, one depending on co-expression of His-Aos1 and untagged Uba2, and a second protocol for separate expression of His-Aos1 and Uba2-His and subsequent reconstitution of the active dimer.	Histidine	94-97	SUMO1 activating enzyme subunit 1	Homo sapiens	98-102
19107418-3	2009	Two alternative procedures are described for the E1 enzyme, one depending on co-expression of His-Aos1 and untagged Uba2, and a second protocol for separate expression of His-Aos1 and Uba2-His and subsequent reconstitution of the active dimer.	Histidine	171-174	SUMO1 activating enzyme subunit 1	Homo sapiens	175-179
19107418-3	2009	Two alternative procedures are described for the E1 enzyme, one depending on co-expression of His-Aos1 and untagged Uba2, and a second protocol for separate expression of His-Aos1 and Uba2-His and subsequent reconstitution of the active dimer.	Histidine	171-174	SUMO1 activating enzyme subunit 1	Homo sapiens	175-179
18836178-2	2008	APTX is a member of the histidine triad superfamily of nucleotide hydrolases and transferases but is distinct from other family members in that it acts upon DNA.	Histidine	24-33	aprataxin	Homo sapiens	0-4
18836178-7	2008	These results pinpoint APTX as the first protein to adopt canonical histidine triad-type reaction chemistry for the repair of DNA.	Histidine	68-77	aprataxin	Homo sapiens	23-27
18629440-7	2008	This is the first report on high level expression of hPLSCR1 with histidine tag in E. coli.	Histidine	66-75	phospholipid scramblase 1	Homo sapiens	53-60
18761348-8	2008	However, the replacement of histidine at position 294 (H294) and phenylalanine at 129 (F129) affected the ATP-induced conformational change of the DNA-HsRad51 filament, although it did not prevent DNA binding.	Histidine	28-37	RAD51 recombinase	Homo sapiens	151-158
18790006-3	2008	CN2 (CNDP2) is a cytosolic enzyme that can hydrolyze carnosine to yield l-histidine and beta-alanine.	Histidine	72-83	carnosine dipeptidase 2	Homo sapiens	0-3
18790006-3	2008	CN2 (CNDP2) is a cytosolic enzyme that can hydrolyze carnosine to yield l-histidine and beta-alanine.	Histidine	72-83	carnosine dipeptidase 2	Homo sapiens	5-10
18790006-8	2008	These results suggest that CN2 is highly expressed in the histaminergic neurons in the tuberomammillary nucleus, implying that it may supply histidine to histaminergic neurons for histamine synthesis.	Histidine	141-150	carnosine dipeptidase 2	Homo sapiens	27-30
18694848-4	2008	Both SMS1 and SMS2 contain two histidines and one aspartic acid which are evolutionary conserved within the lipid phosphate phosphatase superfamily.	Histidine	31-41	sphingomyelin synthase 1	Homo sapiens	5-9
19082310-11	2008	The genetic analysis of tumoral DNA revealed point mutations in two different genes: the wild type CAA at codon 61 of N-RAS mutated to CAT, replacing glycine by histidine (G61H) and the normal GCC sequence at codon 623 of the TSHR gene was replaced by TCC, changing the alanine by serine (A623S).	Histidine	161-170	NRAS proto-oncogene, GTPase	Homo sapiens	118-123
18664522-12	2008	PCaP1 lacks cysteine and histidine residues.	Histidine	25-34	plasma-membrane associated cation-binding protein 1	Arabidopsis thaliana	0-5
18593109-0	2008	Investigation of the copper binding site and the role of histidine as a ligand in riboflavin binding protein.	Histidine	57-66	retinol binding protein 4	Homo sapiens	82-108
18480028-3	2008	Because ACAT enzymes have an intrinsic thioesterase activity, we hypothesized that by analogy with the thioesterase domain of fatty acid synthase, the active site of ACAT enzymes may comprise a catalytic triad of ser-his-asp (S-H-D) amino acid residues.	Histidine	217-220	fatty acid synthase	Homo sapiens	126-145
18485777-3	2008	Sequencing of the PNPO gene revealed a novel homozygous c.284G>A transition in exon 3, resulting in arginine to histidine substitution and reduced activity of the PNPO mutant to 18% relative to the wild type.	Histidine	112-121	pyridoxamine 5'-phosphate oxidase	Homo sapiens	18-22
18582542-1	2008	Modification of catalytic residue His-47 with p-bromophenacyl bromide (BPB) abolished the enzymatic activity of Naja naja atra phospholipase A2 (PLA2).	Histidine	34-37	phospholipase A2 group IIA	Homo sapiens	145-149
18430729-4	2008	The results indicate that binding of the ShB peptide to KcsA involves the ortho and meta protons of Tyr(8), which exhibit the strongest STD effects; the C4H in the imidazole ring of His(16); the methyl protons of Val(4), Leu(7), and Leu(10) and the side chain amine protons of one, if not both, the Lys(18) and Lys(19) residues.	Histidine	182-185	SH2 domain containing adaptor protein B	Homo sapiens	41-44
18280705-1	2008	BACKGROUND: Histidase (histidine ammonia lyase) converts histidine into urocanic acid, the main ultraviolet (UV) light absorption factor of the stratum corneum.	Histidine	23-32	histidine ammonia-lyase	Homo sapiens	12-21
18275838-0	2008	Role of Histidine-152 in cofactor orientation in the PLP-dependent O-acetylserine sulfhydrylase reaction.	Histidine	8-17	proteolipid protein 1	Homo sapiens	53-56
18250167-3	2008	Here, we report a novel K(ATP) channel gating defect caused by CHI-associated Kir6.2 mutations at arginine 301 (to cysteine, glycine, histidine, or proline).	Histidine	134-143	potassium inwardly rectifying channel subfamily J member 11	Homo sapiens	78-84
17964203-3	2008	Treatment of CAI-4 with UV light yielded histidine auxotrophs which could be complemented by HIS4, suggesting that strain CAI-4 is heterozygous for HIS4.	Histidine	41-50	Phosphoribosyl-AMP cyclohydrolase	Candida albicans SC5314	148-152
17964203-5	2008	As expected from a heterozygote, disruption of the functional allele of HIS4 resulted in a his4::hisG-URA3-hisG strain that is auxotrophic for histidine.	Histidine	143-152	Phosphoribosyl-AMP cyclohydrolase	Candida albicans SC5314	72-76
17964203-5	2008	As expected from a heterozygote, disruption of the functional allele of HIS4 resulted in a his4::hisG-URA3-hisG strain that is auxotrophic for histidine.	Histidine	143-152	Phosphoribosyl-AMP cyclohydrolase	Candida albicans SC5314	91-95
18260012-6	2008	In the selected DNA binding peptides, aromatic amino acids such as histidine for CORE and glutamine/aspartic acid for AP2 were found to be abundant amino acids.	Histidine	67-76	transcription factor AP-2 alpha	Homo sapiens	118-121
18220330-1	2008	The tetrapeptide sequence His-Phe-Arg-Trp, derived from melanocyte-stimulating hormone (alphaMSH) and its analogs, causes a decrease in food intake and elevates energy utilization upon binding to the melanocortin-4 receptor (MC4R).	Histidine	26-29	melanocortin 4 receptor	Rattus norvegicus	200-223
18220330-1	2008	The tetrapeptide sequence His-Phe-Arg-Trp, derived from melanocyte-stimulating hormone (alphaMSH) and its analogs, causes a decrease in food intake and elevates energy utilization upon binding to the melanocortin-4 receptor (MC4R).	Histidine	26-29	melanocortin 4 receptor	Rattus norvegicus	225-229
17997327-3	2008	We have been able to isolate milligram quantities of highly purified His(6)-NS1 and NS1-His(6) by nickel affinity chromatography.	Histidine	69-72	influenza virus NS1A binding protein	Homo sapiens	76-79
17997327-3	2008	We have been able to isolate milligram quantities of highly purified His(6)-NS1 and NS1-His(6) by nickel affinity chromatography.	Histidine	88-91	influenza virus NS1A binding protein	Homo sapiens	84-87
20641369-3	2004	Both GRP and BN share an amidated C-terminus sequence homology of seven amino acids, -Trp-Ala-Val-Gly-His-Leu-Met-NH2.	Histidine	102-105	gastrin releasing peptide	Homo sapiens	5-8
17868038-10	2008	The present study represents the first report on recombinant His-tagged GMPS from parasitic protozoa.	Histidine	61-64	guanine monophosphate synthase	Homo sapiens	72-76
18081866-2	2008	Although mammalian Gup1 has a sequence conserved among the membrane-bound O-acyltransferase family, the histidine residue in the motif that is indispensable to the acyltransferase activity of the family has been replaced with leucine.	Histidine	104-113	hedgehog acyltransferase like	Homo sapiens	19-23
18239414-4	2008	The periplasmic domain of CnrX (residues 29- 148) was cloned as a N-terminal His-tagged protein, expressed in Escherichia coli, and purified using affinity chromatography and gel filtration.	Histidine	77-80	periplasmic nickel sensor	Cupriavidus metallidurans CH34	26-30
18177606-2	2008	METHODS: A CDS fragment of human syk was obtained by RT-PCR from human breast cancer cells MDA-MB-468 and then the fragment was cloned into the expression vector pcDNA3.1D/V5-His-TOPO.	Histidine	175-178	spleen associated tyrosine kinase	Homo sapiens	33-36
18073526-9	2007	The cytostatic and cytotoxic effects of Amph required its ribonuclease activity: the enzymatically inactive Amph-2 having histidine at the active site alkylated was ineffective.	Histidine	122-131	bridging integrator 1	Homo sapiens	108-114
17953656-3	2007	Here, we show that replacing histidine in position 105 in the alpha(5) subunit by cysteine strongly stimulates the effect of zolpidem in receptors containing the alpha(5) subunit.	Histidine	29-38	immunoglobulin binding protein 1	Homo sapiens	62-67
17953656-3	2007	Here, we show that replacing histidine in position 105 in the alpha(5) subunit by cysteine strongly stimulates the effect of zolpidem in receptors containing the alpha(5) subunit.	Histidine	29-38	immunoglobulin binding protein 1	Homo sapiens	162-167
17953656-7	2007	Other studies have shown that replacement of these histidines alpha(1) H101, alpha(2) H101, and alpha(3) H126 by arginine, as naturally present in alpha(4) and alpha(6) , leads to benzodiazepine insensitivity of these receptors.	Histidine	51-61	immunoglobulin binding protein 1	Homo sapiens	62-67
17953656-7	2007	Other studies have shown that replacement of these histidines alpha(1) H101, alpha(2) H101, and alpha(3) H126 by arginine, as naturally present in alpha(4) and alpha(6) , leads to benzodiazepine insensitivity of these receptors.	Histidine	51-61	immunoglobulin binding protein 1	Homo sapiens	147-154
17924455-8	2007	By metabolome analysis of intracellular compounds, the amount of histidine and arginine is increased, and the amount of threonine, lysine and nicotinic acid is decreased in the Ami1p-overproducing strain as compared with the control, suggesting that Ami1p may hydrolyse some amides related to amino acid and niacin metabolism in the cell.	Histidine	65-74	glutathione peroxidase GPX2	Saccharomyces cerevisiae S288C	177-182
17878162-7	2007	Matrix-assisted laser desorption and ionization time-of-flight mass spectrometry analysis and mutation experiments revealed that PTP1B inactivation was primarily due to covalent attachment of the quinone to Cys-121 of the enzyme, with binding to His-25 and Cys-215 as well.	Histidine	246-249	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	129-134
20641503-3	2004	Both GRP and BN share an amidated C-terminus sequence homology of seven amino acids, -Trp-Ala-Val-Gly-His-Leu-Met-NH2.	Histidine	102-105	gastrin releasing peptide	Homo sapiens	5-8
17767915-6	2007	We further generated histidine-substituted Tca HDAC mutants and investigated their role in biochemical and cellular activity of the enzyme.	Histidine	21-30	histone deacetylase 9	Homo sapiens	47-51
17890311-4	2007	In order to understand the details of the inhibitory mechanism of CIII, we cloned and expressed the protein with an N-terminal six-histidine tag.	Histidine	131-140	cIII	Escherichia virus Lambda	66-70
17905810-3	2007	We propose that cytochrome b(561) has a specific mechanism to facilitate the concerted proton/electron transfer from ascorbate by exploiting a cycle of deprotonated and protonated states of the N(delta1) atom of the axial His residue at the extravesicular haem center, as an initial step of the transmembrane electron transfer.	Histidine	222-225	mitochondrially encoded cytochrome b	Homo sapiens	16-28
17924626-12	2007	In another dendrimer, HG3 ((AcIlePro)(8)(DapIleThr)(4)(DapHisAla)(2)DapHisLeuNH2) by contrast, catalysis by a core of three histidine residues is unaffected by the outer dendritic layers.	Histidine	124-133	polycystin 1, transient receptor potential channel interacting pseudogene 3	Homo sapiens	22-25
17869271-4	2007	Our data demonstrate that exchanging Cys for His and vice versa in the highly conserved Zn-coordinating HCCH motif disrupted Vif function and interaction with Cul5.	Histidine	45-48	Vif	Human immunodeficiency virus 1	125-128
18071584-7	2007	The RPLP1 gene was overexpressed in E. coli and the result indicated that RPLP1 fusion with the N-terminally His-tagged form gave rise to the accumulation of an expected 18kDa polypeptide, which was in accordance with the predicted protein and could also be used to purify the protein and study its function.	Histidine	109-112	60S acidic ribosomal protein P1	Ailuropoda melanoleuca	4-9
17604919-5	2007	frRunx1 had an extra stretch of eight histidine residues, while frRunx2 lacked the poly-glutamine/-alanine stretch that is a hallmark of the mammalian Runx2 genes.	Histidine	38-47	runt-related transcription factor 1	Takifugu rubripes	0-7
17576516-7	2007	Histidine 23 of the archaeal dPGM of T. acidophilum, which corresponds to active site histidine in dPGMs from bacteria and eukarya, was exchanged for alanine by site directed mutagenesis.	Histidine	0-9	Phosphoglucose mutase 1	Drosophila melanogaster	29-33
17576516-7	2007	Histidine 23 of the archaeal dPGM of T. acidophilum, which corresponds to active site histidine in dPGMs from bacteria and eukarya, was exchanged for alanine by site directed mutagenesis.	Histidine	86-95	Phosphoglucose mutase 1	Drosophila melanogaster	29-33
17697822-6	2007	The CFH Tyr402His (rs1061170) polymorphism was determined (His(402) allele 37%), and using 3 tagging polymorphisms (rs1130864, rs1205, and rs3093068), CRP haplotypes were inferred (1 = CTC, 2 = TCC, 3 = CCC, 4 = CCG; frequencies of 33%, 32%, 30%, and 6%, respectively).	Histidine	14-17	complement factor H	Homo sapiens	4-7
17567043-0	2007	Probing the role of the histidine 759 ligand in cobalamin-dependent methionine synthase.	Histidine	24-33	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	48-87
17550235-5	2007	By contrast, the BARD1 BRCT selectivity pocket P2 exhibits distinct structural features, including two prominent histidine residues, His685 and His686, which may be important for ligand binding.	Histidine	113-122	BRCA1 associated RING domain 1	Homo sapiens	17-22
17629352-1	2007	beta-Lactotensin (His-Ile-Arg-Leu) is an ileum-contracting tetrapeptide isolated from bovine beta-lactoglobulin.	Histidine	18-21	beta-lactoglobulin	Bos taurus	93-111
17515815-11	2007	In the polymorphism of alcohol dehydrogenase (ADH2), prevalence of osteophyte formation without disc height narrowing was less in His/Arg (odds ratio = 0.57, P = 0.041) and Arg/Arg (odds ratio = 0.41, P = 0.18) than His/His.	Histidine	130-133	aldo-keto reductase family 1 member A1	Homo sapiens	23-44
17515815-11	2007	In the polymorphism of alcohol dehydrogenase (ADH2), prevalence of osteophyte formation without disc height narrowing was less in His/Arg (odds ratio = 0.57, P = 0.041) and Arg/Arg (odds ratio = 0.41, P = 0.18) than His/His.	Histidine	130-133	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	46-50
17515815-11	2007	In the polymorphism of alcohol dehydrogenase (ADH2), prevalence of osteophyte formation without disc height narrowing was less in His/Arg (odds ratio = 0.57, P = 0.041) and Arg/Arg (odds ratio = 0.41, P = 0.18) than His/His.	Histidine	216-219	aldo-keto reductase family 1 member A1	Homo sapiens	23-44
17515815-11	2007	In the polymorphism of alcohol dehydrogenase (ADH2), prevalence of osteophyte formation without disc height narrowing was less in His/Arg (odds ratio = 0.57, P = 0.041) and Arg/Arg (odds ratio = 0.41, P = 0.18) than His/His.	Histidine	216-219	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	46-50
17515815-11	2007	In the polymorphism of alcohol dehydrogenase (ADH2), prevalence of osteophyte formation without disc height narrowing was less in His/Arg (odds ratio = 0.57, P = 0.041) and Arg/Arg (odds ratio = 0.41, P = 0.18) than His/His.	Histidine	216-219	aldo-keto reductase family 1 member A1	Homo sapiens	23-44
17515815-11	2007	In the polymorphism of alcohol dehydrogenase (ADH2), prevalence of osteophyte formation without disc height narrowing was less in His/Arg (odds ratio = 0.57, P = 0.041) and Arg/Arg (odds ratio = 0.41, P = 0.18) than His/His.	Histidine	216-219	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	46-50
17307731-4	2007	Analysis of single-site mutants of the TSG-6 Link module indicated that the loss in affinity above pH 6.0 is mediated by the change in ionization state of a histidine residue (His(4)) that is not within the HA-binding site.	Histidine	157-166	TNF alpha induced protein 6	Homo sapiens	39-44
17307731-4	2007	Analysis of single-site mutants of the TSG-6 Link module indicated that the loss in affinity above pH 6.0 is mediated by the change in ionization state of a histidine residue (His(4)) that is not within the HA-binding site.	Histidine	176-179	TNF alpha induced protein 6	Homo sapiens	39-44
17202139-1	2007	The imidazole (15)N signals of histidine 64 (His(64)), involved in the catalytic function of human carbonic anhydrase II (hCAII), were assigned unambiguously.	Histidine	31-40	carbonic anhydrase 2	Homo sapiens	99-120
17202139-1	2007	The imidazole (15)N signals of histidine 64 (His(64)), involved in the catalytic function of human carbonic anhydrase II (hCAII), were assigned unambiguously.	Histidine	31-40	carbonic anhydrase 2	Homo sapiens	122-127
17202139-1	2007	The imidazole (15)N signals of histidine 64 (His(64)), involved in the catalytic function of human carbonic anhydrase II (hCAII), were assigned unambiguously.	Histidine	45-48	carbonic anhydrase 2	Homo sapiens	99-120
17202139-1	2007	The imidazole (15)N signals of histidine 64 (His(64)), involved in the catalytic function of human carbonic anhydrase II (hCAII), were assigned unambiguously.	Histidine	45-48	carbonic anhydrase 2	Homo sapiens	122-127
17227754-9	2007	The catalytic function of HS-2OST appears to involve two histidine residues (His140 and His142), whereas only one histidine (His168) of CS 2-OST is likely to be critical.	Histidine	114-123	Chitin synthase 2	Drosophila melanogaster	136-140
17239391-4	2007	In contrast cysteine 922 (within NS2) is only required for NS2/3 auto-cleavage activity and histidine 1175 is only required for NS3 activity.	Histidine	92-101	KRAS proto-oncogene, GTPase	Homo sapiens	128-131
17352366-6	2007	RESULTS: Seventy patients (14%) were homozygous for the histidine variant (HH) of CFH, 237 (48%) were heterozygous for the histidine variant (HY), and 186 (38%) were homozygous for the tyrosine variant (YY).	Histidine	56-65	complement factor H	Homo sapiens	82-85
17200862-4	2007	In this complex, NDPK B acts as a protein histidine kinase phosphorylating Gbeta at histidine residue 266 (His266).	Histidine	42-51	cytidine/uridine monophosphate kinase 1	Rattus norvegicus	17-21
17324336-6	2007	Importantly, we observed linkage among polymorphisms within and between FcgammaRIIa and FcgammaRIIIa, including the expression of histidine at FcgammaRIIa-131 and valine at FcgammaRIIIa, both of which are associated with enhanced responses to rituximab.	Histidine	130-139	Fc gamma receptor IIIa	Homo sapiens	88-100
17040910-4	2006	Four conserved residues in the C-terminal loop of DPP8 (Phe(822), Val(833), Tyr(844), and His(859)), corresponding to those located at the dimer interface of DPP-IV, were individually mutated to Ala.	Histidine	90-93	dipeptidyl peptidase 8	Homo sapiens	50-54
17081196-4	2006	In this study, recombinant prolidase was produced as a fusion protein with an N-terminal histidine tag in eukaryotic and prokaryotic hosts and purified in a single step using immobilized metal affinity chromatography.	Histidine	89-98	peptidase D	Homo sapiens	27-36
16989765-9	2006	Bioinformatic analyses indicate that histidine 158 is an evolutionarily conserved residue in most vertebrate TIMP homologs and predict that substitution by arginine disrupts TIMP3 function.	Histidine	37-46	TIMP metallopeptidase inhibitor 3	Homo sapiens	174-179
17035525-11	2006	In HEK-293 cells, coexpressed hemagglutinin-tagged KCC2 assembled with histidine-tagged KCC2, demonstrating formation of homomers.	Histidine	71-80	solute carrier family 12 member 5	Homo sapiens	51-55
17035525-11	2006	In HEK-293 cells, coexpressed hemagglutinin-tagged KCC2 assembled with histidine-tagged KCC2, demonstrating formation of homomers.	Histidine	71-80	solute carrier family 12 member 5	Homo sapiens	88-92
17121011-4	2006	The recombinant protein NASP was purified from the supernatant with Ni2 -NTA His-bind resin under native conditions.	Histidine	77-80	nuclear autoantigenic sperm protein	Homo sapiens	24-28
16807956-3	2006	l-His was a potent activator of isozymes I, VA, VII, and XIV, and a weaker activator of hCA II and IV.	Histidine	0-5	carbonic anhydrase 2	Homo sapiens	88-101
16807956-5	2006	The structures as determined by X-ray crystallography of the hCA II-l-His/d-His adducts showed the activators to be anchored at the entrance of the active site, contributing to extended networks of hydrogen bonds with amino acid residues/water molecules present in the cavity, explaining their different potency and interaction patterns with various isozymes.	Histidine	70-73	carbonic anhydrase 2	Homo sapiens	61-67
16807956-5	2006	The structures as determined by X-ray crystallography of the hCA II-l-His/d-His adducts showed the activators to be anchored at the entrance of the active site, contributing to extended networks of hydrogen bonds with amino acid residues/water molecules present in the cavity, explaining their different potency and interaction patterns with various isozymes.	Histidine	76-79	carbonic anhydrase 2	Homo sapiens	61-67
16822869-9	2006	These data suggest that highly conserved arginine and histidine residues may compensate for variation elsewhere in the a1 and a2 plasminogen binding repeats, and may explain the maintenance of high affinity plasminogen binding by naturally occurring variants of PAM.	Histidine	54-63	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	262-265
16714405-7	2006	This shortfall in our basic understanding of AtPCS1 is addressed here by the results of systematic site-directed mutagenesis studies that demonstrate that not only Cys-56 but also His-162 and Asp-180 are indeed required for net PC synthesis.	Histidine	180-183	Eukaryotic aspartyl protease family protein	Arabidopsis thaliana	45-51
16685272-6	2006	Immunocytochemistry of HuH7 cells transiently transfected with V5-His-tagged dermcidin confirmed targeting to the secretory pathway.	Histidine	66-69	dermcidin	Homo sapiens	77-86
16332725-6	2006	Individuals having ALDH2 Glu/Glu with ADH2 Arg+, ALDH2 Lys+ with ADH2 His/His and ALDH2 Lys+ with ADH2 Arg+ showed ORs of 0.10(0.04-0.21), 0.10 (0.06-0.19) and 1.36 (0.94-1.97), respectively, compared with ALDH2 Glu/Glu with ADH2 His/His.	Histidine	70-73	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	65-69
16332725-6	2006	Individuals having ALDH2 Glu/Glu with ADH2 Arg+, ALDH2 Lys+ with ADH2 His/His and ALDH2 Lys+ with ADH2 Arg+ showed ORs of 0.10(0.04-0.21), 0.10 (0.06-0.19) and 1.36 (0.94-1.97), respectively, compared with ALDH2 Glu/Glu with ADH2 His/His.	Histidine	70-73	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	65-69
16332725-6	2006	Individuals having ALDH2 Glu/Glu with ADH2 Arg+, ALDH2 Lys+ with ADH2 His/His and ALDH2 Lys+ with ADH2 Arg+ showed ORs of 0.10(0.04-0.21), 0.10 (0.06-0.19) and 1.36 (0.94-1.97), respectively, compared with ALDH2 Glu/Glu with ADH2 His/His.	Histidine	70-73	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	65-69
16510783-4	2006	The gene HIS3 from the histidine synthesis pathway was recruited to the GAL system, responsible for galactose utilization in the yeast S. cerevisiae.	Histidine	23-32	imidazoleglycerol-phosphate dehydratase HIS3	Saccharomyces cerevisiae S288C	9-13
16510783-5	2006	Following a switch from galactose to glucose--from induced to repressed conditions of the GAL system--in histidine-lacking chemostats (where the recruited HIS3 is essential), the regulatory system reprogrammed to adaptively tune HIS3 expression, allowing the cells to grow competitively in pure glucose.	Histidine	105-114	imidazoleglycerol-phosphate dehydratase HIS3	Saccharomyces cerevisiae S288C	155-159
16510783-5	2006	Following a switch from galactose to glucose--from induced to repressed conditions of the GAL system--in histidine-lacking chemostats (where the recruited HIS3 is essential), the regulatory system reprogrammed to adaptively tune HIS3 expression, allowing the cells to grow competitively in pure glucose.	Histidine	105-114	imidazoleglycerol-phosphate dehydratase HIS3	Saccharomyces cerevisiae S288C	229-233
17283967-19	2006	This indicates both that supportive cells are metabolically less active than feather-producing cells, and that putative histidine-rich proteins are only present in cells synthesizing feather keratin.	Histidine	120-129	keratin	Gallus gallus	191-198
16567399-5	2006	On the other hand, a mutant chicken Src, in which the His-122 residue is replaced by Arg, showed decreased recognition by mAb327.	Histidine	54-57	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	36-39
16442528-11	2006	Moreover, the NTHK1 functional kinase domain phosphorylated the HIS and ATP subdomains, and five putative phosphorylation sites were identified in these two subdomains.	Histidine	64-67	histidine kinase1	Nicotiana tabacum	14-19
16388603-0	2006	Sir2 protein deacetylases: evidence for chemical intermediates and functions of a conserved histidine.	Histidine	92-101	sirtuin 1	Homo sapiens	0-4
16388603-4	2006	In this study, Sir2-catalyzed reactions are shown to transfer an 18O label from the peptide acetyl group to the ribose 1"-position of OAADPr, providing direct evidence for the formation of a covalent alpha-1"-O-alkylamidate, whose existence is further supported by the observed methanolysis of the alpha-1"-O-alkylamidate intermediate to yield beta-1"-O-methyl-ADP-ribose in a Sir2 histidine-to-alanine mutant.	Histidine	382-391	sirtuin 1	Homo sapiens	15-19
16388603-4	2006	In this study, Sir2-catalyzed reactions are shown to transfer an 18O label from the peptide acetyl group to the ribose 1"-position of OAADPr, providing direct evidence for the formation of a covalent alpha-1"-O-alkylamidate, whose existence is further supported by the observed methanolysis of the alpha-1"-O-alkylamidate intermediate to yield beta-1"-O-methyl-ADP-ribose in a Sir2 histidine-to-alanine mutant.	Histidine	382-391	sirtuin 1	Homo sapiens	377-381
16121393-8	2006	In contrast to the wild-type and EC recombinant proteins, rSPARC(E268F)-His, a point substitution mutant at the Z position of EF-hand 2, failed to exhibit both Ca2+-dependent changes in alpha-helical secondary structure and anti-spreading activity.	Histidine	72-75	secreted protein acidic and cysteine rich	Rattus norvegicus	58-70
16080185-4	2005	Digestion of the hexahistidine tag of MBP-His(6) by Factor Xa and HT15-MBP by DAPase-1 was successful.	Histidine	42-45	coagulation factor X	Homo sapiens	52-61
16252006-6	2005	Thus, our findings indicate that WINAC associates with chromatin through a physical interaction between the WSTF bromodomain and acetylated his tones, which appears to be indispensable for VDR/promoter association for ligand-induced transrepression of 1alpha(OH)ase gene expression.	Histidine	140-143	vitamin D receptor	Homo sapiens	189-192
16109718-10	2005	In contrast, the interaction of AUF1 with the ATF3 mRNA is decreased in histidine-deprived cells relative to control cells.	Histidine	72-81	heterogeneous nuclear ribonucleoprotein D	Homo sapiens	32-36
16201751-0	2005	Structural characterization of the proximal and distal histidine environment of cytoglobin and neuroglobin.	Histidine	55-64	neuroglobin	Homo sapiens	95-106
16201751-1	2005	Cytoglobin (Cgb) and neuroglobin (Ngb) are the first examples of hexacoordinated globins from humans and other vertebrates in which a histidine (His) residue at the sixth position of the heme iron is an endogenous ligand in both the ferric and ferrous forms.	Histidine	134-143	neuroglobin	Homo sapiens	21-32
16201751-1	2005	Cytoglobin (Cgb) and neuroglobin (Ngb) are the first examples of hexacoordinated globins from humans and other vertebrates in which a histidine (His) residue at the sixth position of the heme iron is an endogenous ligand in both the ferric and ferrous forms.	Histidine	134-143	neuroglobin	Homo sapiens	34-37
16201751-1	2005	Cytoglobin (Cgb) and neuroglobin (Ngb) are the first examples of hexacoordinated globins from humans and other vertebrates in which a histidine (His) residue at the sixth position of the heme iron is an endogenous ligand in both the ferric and ferrous forms.	Histidine	145-148	neuroglobin	Homo sapiens	21-32
16201751-1	2005	Cytoglobin (Cgb) and neuroglobin (Ngb) are the first examples of hexacoordinated globins from humans and other vertebrates in which a histidine (His) residue at the sixth position of the heme iron is an endogenous ligand in both the ferric and ferrous forms.	Histidine	145-148	neuroglobin	Homo sapiens	34-37
16215176-6	2005	Furthermore, the inactivation of C. albicans Gcn2 only partially attenuates growth under amino acid starvation conditions and resistance to the histidine analogue 3-aminotriazole.	Histidine	144-153	serine/threonine-protein kinase GCN2	Saccharomyces cerevisiae S288C	45-49
15935379-5	2005	tRNase Z is a member of the beta-lactamase family of metal-dependent hydrolases, the signature sequence of which, the conserved histidine cluster (HxHxDH), is essential for activity.	Histidine	128-137	Ribonuclease Z	Drosophila melanogaster	0-8
15895369-1	2005	Zic genes comprise a family of transcription factors, characterized by the presence of a zinc-finger domain containing two cysteines and two histidines (C2-H2).	Histidine	141-151	zinc finger protein of the cerebellum 1	Mus musculus	0-3
15840587-4	2005	Biochemical analysis showed that bacterial His-tagged p12 could be converted into a dimeric p25 in a reducing agent-dependent manner, and mutating the only cysteine residue of p12 (Cys(105) --&gt; Ala(105)) abolished the dimerization.	Histidine	43-46	tubulin polymerization promoting protein	Homo sapiens	92-95
15621250-9	2005	By N-terminal analysis using aminopeptidase and RP-HPLC, it was confirmed that the lowered bioactivity of VAPG stemmed from the polymer conjugation to N-terminal histidine moieties, which actively participate in binding to GLP-1 receptors, resulting in only 16% of N-terminal histidine remaining intact after the conjugation reaction.	Histidine	162-171	glucagon	Rattus norvegicus	223-228
15896208-3	2005	The new allele differs from Cw*020202 by one nucleotide substitution at nucleotide 61 (G--&gt;A) of exon 2, which translates to a difference of one amino acid at residue 21 (His--&gt;Arg) of the HLA-C heavy chain.	Histidine	174-177	major histocompatibility complex, class I, C	Homo sapiens	195-200
15900495-6	2005	Most of the protein sequence features involved in binding ATP are conserved, with two exceptions: chicken TAP1 has a glycine in the switch region where other TAPs have glutamine or histidine, and both chicken TAP genes have serines in the C motif where mammalian TAP2 has an alanine.	Histidine	181-190	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Gallus gallus	106-110
15900495-6	2005	Most of the protein sequence features involved in binding ATP are conserved, with two exceptions: chicken TAP1 has a glycine in the switch region where other TAPs have glutamine or histidine, and both chicken TAP genes have serines in the C motif where mammalian TAP2 has an alanine.	Histidine	181-190	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Gallus gallus	106-109
15761121-3	2005	Significant association (P = 4.95 x 10(-10)) was identified within the regulation of complement activation locus and was centered over a tyrosine-402 --&gt; histidine-402 protein polymorphism in the gene encoding complement factor H.	Histidine	157-166	complement factor H	Homo sapiens	213-232
16511042-3	2005	Although ZmHP1 with an N-terminal His tag could be crystallized using sodium chloride as a precipitant, the crystals diffracted poorly to only 3.2 A resolution.	Histidine	34-37	histidine-containing phosphotransfer protein	Zea mays	9-14
15900706-8	2005	A recombinant, C-terminally His-tagged synaptobrevin fragment bound to nickel beads specifically bound synaptophysin, syntaxin and SNAP25 from vesicular detergent extracts.	Histidine	28-31	synaptophysin	Homo sapiens	103-116
15819897-3	2005	Moreover, flash photolysis experiments at high temperatures reveal that Ngb remains functional at 90 degrees C. Human Ngb may have a disulfide bond in the CD loop region; reduction of the disulfide bond increases the affinity of the iron atom for the distal (E7) histidine, and leads to a 3 degrees C increase in the T(m) for ferrous Ngb.	Histidine	263-272	neuroglobin	Homo sapiens	72-75
15819897-3	2005	Moreover, flash photolysis experiments at high temperatures reveal that Ngb remains functional at 90 degrees C. Human Ngb may have a disulfide bond in the CD loop region; reduction of the disulfide bond increases the affinity of the iron atom for the distal (E7) histidine, and leads to a 3 degrees C increase in the T(m) for ferrous Ngb.	Histidine	263-272	neuroglobin	Homo sapiens	118-121
15819897-3	2005	Moreover, flash photolysis experiments at high temperatures reveal that Ngb remains functional at 90 degrees C. Human Ngb may have a disulfide bond in the CD loop region; reduction of the disulfide bond increases the affinity of the iron atom for the distal (E7) histidine, and leads to a 3 degrees C increase in the T(m) for ferrous Ngb.	Histidine	263-272	neuroglobin	Homo sapiens	118-121
15819897-7	2005	Only globins with a high affinity of the distal histidine show the very high thermal stability, indicating that stable hexa-coordination is necessary for the enhanced thermal stability; the CD loop which contains the cysteines appears as a critical region in the neuroglobin thermal stability, because it may influence the affinity of the distal histidine.	Histidine	48-57	neuroglobin	Homo sapiens	263-274
15804708-2	2005	This antibody is directed against the histidyl-tRNA synthetase which catalyses the binding of the histidine to its cognate tRNA during protein synthesis.	Histidine	98-107	histidyl-tRNA synthetase 1	Homo sapiens	38-62
15667203-0	2005	Structural and kinetic characterization of active-site histidine as a proton shuttle in catalysis by human carbonic anhydrase II.	Histidine	55-64	carbonic anhydrase 2	Homo sapiens	107-128
15667203-1	2005	In the catalysis of the hydration of carbon dioxide and dehydration of bicarbonate by human carbonic anhydrase II (HCA II), a histidine residue (His64) shuttles protons between the zinc-bound solvent molecule and the bulk solution.	Histidine	126-135	carbonic anhydrase 2	Homo sapiens	92-113
15681171-9	2005	The results suggest that previously observed alterations in the activity of histidase, which were correlated to dietary protein intake, are mediated by rapid changes in the mRNA expression of this enzyme, and are not necessarily related to dietary histidine intake.	Histidine	248-257	histidine ammonia-lyase	Homo sapiens	76-85
15684398-5	2005	RC-68 contains the intact histidine motif, and hence it might be a functional counterpart of CPSF-73, whereas RC-74 lacks this motif, thus resembling CPSF-100.	Histidine	26-35	integrator complex subunit 11	Homo sapiens	0-5
15659493-5	2005	Two were commonly observed (FcgammaRIIIA-48 and FcgammaRIIIA-158) and predicted for amino acid polymorphisms at FcgammaRIIIA-48: leucine/leucine (L/L), leucine/arginine (L/R), and leucine/histidine (L/H).	Histidine	188-197	Fc gamma receptor IIIa	Homo sapiens	28-40
15659493-5	2005	Two were commonly observed (FcgammaRIIIA-48 and FcgammaRIIIA-158) and predicted for amino acid polymorphisms at FcgammaRIIIA-48: leucine/leucine (L/L), leucine/arginine (L/R), and leucine/histidine (L/H).	Histidine	188-197	Fc gamma receptor IIIa	Homo sapiens	48-60
15659493-5	2005	Two were commonly observed (FcgammaRIIIA-48 and FcgammaRIIIA-158) and predicted for amino acid polymorphisms at FcgammaRIIIA-48: leucine/leucine (L/L), leucine/arginine (L/R), and leucine/histidine (L/H).	Histidine	188-197	Fc gamma receptor IIIa	Homo sapiens	48-60
15574461-3	2005	To clarify the molecular mechanisms of this low level of activity, we co-expressed human ferrochelatase carrying His- and HA-tags in a tandem fashion in Escherichia coli.	Histidine	113-116	ferrochelatase	Homo sapiens	89-103
15385420-4	2005	We discovered a polymorphism in exon 2 of the porcine TBG gene that results in an amino acid change of the consensus histidine to an asparagine.	Histidine	117-126	serpin family A member 7	Homo sapiens	54-57
15385420-6	2005	Binding studies indicate altered binding characteristics of the allelic variants of TBG with the asparagine (White Composite) isoform having significantly greater affinity for thyroxine than the histidine (Meishan) isoform.	Histidine	195-204	serpin family A member 7	Homo sapiens	84-87
15610045-1	2004	The human DNA repair protein, hXRCC1, which is required for DNA single-strand break repair and genetic stability was produced as a histidine-tagged polypeptide in Escherichia coli, purified by affinity chromatography, and subjected to sedimentation and spectroscopic analyses.	Histidine	131-140	X-ray repair cross complementing 1	Homo sapiens	30-36
15590984-7	2004	We cloned the complete CXCL10 cDNA in a mammalian expression vector with the CMV promoter, pcDNA3.1D/V5-His-TOPO, and confirmed its expression with rat CXCL10 antibody and V5 antibody.	Histidine	104-107	C-X-C motif chemokine ligand 10	Homo sapiens	23-29
15488767-1	2004	Both the ferrous and ferric forms of wild-type neuroglobin are found to be hexacoordinated with axial ligation of the F8-His and E7-His.	Histidine	121-124	neuroglobin	Homo sapiens	47-58
15488767-1	2004	Both the ferrous and ferric forms of wild-type neuroglobin are found to be hexacoordinated with axial ligation of the F8-His and E7-His.	Histidine	132-135	neuroglobin	Homo sapiens	47-58
15325515-4	2004	We cloned and expressed the ORF6 gene, which encodes the M/VP-2, as a fusion protein with a polyhistidine metal-binding tag (6 x His-tag) in Autographa californica nuclear polyhedrosis virus (baculovirus) under the control of the polyhedrin promoter.	Histidine	129-132	dachsous cadherin-related 1	Homo sapiens	57-63
15804833-4	2004	As with some plant and bacterial globins, neuroglobin and cytoglobin hemes are hexacoordinate in the absence of external ligands, in that the heme iron atom coordinates both a proximal and a distal His residue.	Histidine	198-201	neuroglobin	Homo sapiens	42-53
15322091-10	2004	Following mutation of a histidine (corresponding to the position 115 in human Nox2) to leucine, this interaction was abolished.	Histidine	24-33	cytochrome b-245 beta chain	Homo sapiens	78-82
15326175-5	2004	The pH effect was inhibited by copper ions and was reduced or lost in cells expressing mutated TDAG8 in which histidine residues were changed to phenylalanine.	Histidine	110-119	G-protein coupled receptor 65	Mus musculus	95-100
15299006-2	2004	Two new globin proteins have recently been discovered in vertebrates, neuroglobin in neurons and cytoglobin in all tissues, both showing heme hexacoordination by the distal His(E7) in the absence of gaseous ligands.	Histidine	173-176	neuroglobin	Homo sapiens	70-81
15358370-3	2004	The highest expression level obtained with the C-terminally His-tagged MC4r corresponded to 0.25mg active receptor/litre culture volume.	Histidine	60-63	melanocortin 4 receptor	Homo sapiens	71-75
15358370-4	2004	Addition of a viral signal peptide at the N-terminus of the His-tagged MC4r did not improve the expression level.	Histidine	60-63	melanocortin 4 receptor	Homo sapiens	71-75
15388974-8	2004	Through transient expression assays with T87 protoplasts, it is shown that the intracellular localization profiles of the phosphorelay intermediate Arabidopsis histidine-containing phosphotransfer factor (AHPs; e.g., AHP1 and AHP4) were markedly affected in response to cytokinin, but those of type-A ARRs were not (e.g., ARR15 and ARR16).	Histidine	160-169	response regulator 15	Arabidopsis thaliana	322-327
15388974-8	2004	Through transient expression assays with T87 protoplasts, it is shown that the intracellular localization profiles of the phosphorelay intermediate Arabidopsis histidine-containing phosphotransfer factor (AHPs; e.g., AHP1 and AHP4) were markedly affected in response to cytokinin, but those of type-A ARRs were not (e.g., ARR15 and ARR16).	Histidine	160-169	response regulator 16	Arabidopsis thaliana	332-337
15612468-5	2004	RESULTS: The proportion of XRCC1 c.194Arg/Trp + Trp/Trp genotypes in the case group was lower than that of the control group, while there was a higher proportion for XRCC1 C.280Arg/His + His/His in the case group.	Histidine	181-184	X-ray repair cross complementing 1	Homo sapiens	27-32
15612468-5	2004	RESULTS: The proportion of XRCC1 c.194Arg/Trp + Trp/Trp genotypes in the case group was lower than that of the control group, while there was a higher proportion for XRCC1 C.280Arg/His + His/His in the case group.	Histidine	187-190	X-ray repair cross complementing 1	Homo sapiens	27-32
15612468-5	2004	RESULTS: The proportion of XRCC1 c.194Arg/Trp + Trp/Trp genotypes in the case group was lower than that of the control group, while there was a higher proportion for XRCC1 C.280Arg/His + His/His in the case group.	Histidine	187-190	X-ray repair cross complementing 1	Homo sapiens	27-32
15612468-7	2004	CONCLUSION: The risk of BP for subjects carrying XRCC1 c.194Arg/Trp + Trp/Trp genotypes may decrease while for individuals carrying XRCC1 c.280Arg/His + His/His genotypes may increase.	Histidine	147-150	X-ray repair cross complementing 1	Homo sapiens	49-54
15612468-7	2004	CONCLUSION: The risk of BP for subjects carrying XRCC1 c.194Arg/Trp + Trp/Trp genotypes may decrease while for individuals carrying XRCC1 c.280Arg/His + His/His genotypes may increase.	Histidine	153-156	X-ray repair cross complementing 1	Homo sapiens	49-54
15358233-5	2004	Furthermore, His-p53 and FLAG-XPG, but not PCNA, stimulated the Tg DNA glycosylase/AP lyase activity of GST-NTH1 or NTH1.	Histidine	13-16	nth like DNA glycosylase 1	Homo sapiens	108-112
15258613-7	2004	Furthermore, the residues that orient and stabilize the active-site histidine of otubain 2 are different from other cysteine proteases.	Histidine	68-77	OTU deubiquitinase, ubiquitin aldehyde binding 2	Homo sapiens	81-90
15294184-3	2004	pDNA encoding the luciferase was complexed with histidylated polylysine (His-pLK), a polymer that requires acidic pH for pDNA endosomal release.	Histidine	73-76	polo like kinase 1	Homo sapiens	77-80
15161925-8	2004	Deletion of these adjacent sequences or mutation of the conserved cysteines or histidine in the zinc binding motif not only inhibits protein interaction but also eliminates DNA binding, demonstrating that DEAF-1 protein-protein interaction is required for DNA recognition.	Histidine	79-88	DEAF1 transcription factor	Homo sapiens	205-211
15138272-1	2004	Histidine-rich glycoprotein (HRG) is an alpha2-glycoprotein found in mammalian plasma at high concentrations (approximately 150 microg/ml) and is distinguished by its high content of histidine and proline.	Histidine	183-192	histidine rich glycoprotein	Homo sapiens	0-27
15138272-1	2004	Histidine-rich glycoprotein (HRG) is an alpha2-glycoprotein found in mammalian plasma at high concentrations (approximately 150 microg/ml) and is distinguished by its high content of histidine and proline.	Histidine	183-192	histidine rich glycoprotein	Homo sapiens	29-32
15138272-2	2004	Structurally, HRG is a modular protein consisting of an N-terminal cystatin-like domain (N1N2), a central histidine-rich region (HRR) flanked by proline-rich sequences, and a C-terminal domain.	Histidine	106-115	histidine rich glycoprotein	Homo sapiens	14-17
15196988-7	2004	In contrast, the catalytic efficiency of the CYP2A13 Ala(117) --&gt; Val and His(372) --&gt; Arg mutants was greatly increased (2.65 and 2.60 versus 0.31 for wild-type CYP2A13 protein).	Histidine	77-80	cytochrome P450 family 2 subfamily A member 13	Homo sapiens	45-52
15196988-7	2004	In contrast, the catalytic efficiency of the CYP2A13 Ala(117) --&gt; Val and His(372) --&gt; Arg mutants was greatly increased (2.65 and 2.60 versus 0.31 for wild-type CYP2A13 protein).	Histidine	77-80	cytochrome P450 family 2 subfamily A member 13	Homo sapiens	168-175
15326283-5	2004	In the wild-type insulin, binding of zinc ions by B10 His overcomes this problem, whereas in the B10 mutant this possibility is ruled out by the absence of the zinc binding site.	Histidine	54-57	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	50-53
14996700-2	2004	PRCP cDNA was cloned in pMT/BIP/V5-HIS-C, transfected into Schneider insect (S2) cells, and purified from serum-free media.	Histidine	35-38	prolylcarboxypeptidase	Homo sapiens	0-4
15165844-1	2004	Caenorhabditis elegans PEB-1 is a novel protein containing a DNA-binding domain in its N terminus, which includes a Cys/His-rich FLYWCH motif also found in Drosophila Mod(mdg4) proteins, and a large C-terminal domain of unknown function.	Histidine	120-123	FLYWCH-type domain-containing protein	Caenorhabditis elegans	23-28
15165844-1	2004	Caenorhabditis elegans PEB-1 is a novel protein containing a DNA-binding domain in its N terminus, which includes a Cys/His-rich FLYWCH motif also found in Drosophila Mod(mdg4) proteins, and a large C-terminal domain of unknown function.	Histidine	120-123	modifier of mdg4	Drosophila melanogaster	167-175
15169884-5	2004	Mutations of the cysteine or histidine residues in the C2HR motif abolish the interaction of Nizp1 with NSD1 and compromise the ability of Nizp1 to repress transcription.	Histidine	29-38	zinc finger protein 496	Homo sapiens	93-98
15169884-5	2004	Mutations of the cysteine or histidine residues in the C2HR motif abolish the interaction of Nizp1 with NSD1 and compromise the ability of Nizp1 to repress transcription.	Histidine	29-38	zinc finger protein 496	Homo sapiens	139-144
15136674-9	2004	Sequence analysis of the coding regions of MYH7 revealed an A--&gt;T transversion at nucleotide position 25596 (M57965) resulting in a histidine-to-leucine amino acid change at residue 1904 (H1904L).	Histidine	135-144	myosin heavy chain 7	Homo sapiens	43-47
15113176-3	2004	pH values calculated from the (31)P NMR spectra using the chemical shifts of the C-6 line of histidine in the (1)H spectra and the chemical shifts of inorganic phosphate in the (31)P spectra confirmed the different muscle glycogen status in the tissues.	Histidine	93-102	LOW QUALITY PROTEIN: complement component C6	Oryctolagus cuniculus	81-84
15115518-4	2004	The mutation is predicted to result in an asparagine to histidine substitution (N160H) at the beginning of the alpha-helical 1A domain of keratin 9.	Histidine	56-65	keratin 9	Homo sapiens	138-147
15066755-1	2004	GALA is a 30 amino acid synthetic peptide with a glutamic acid-alanine-leucine-alanine (EALA) repeat that also contains a histidine and tryptophan residue as spectroscopic probes.	Histidine	122-131	galactosidase alpha	Homo sapiens	0-4
15084118-13	2004	Furthermore, when the His-DPhe-Arg-Trp sequence is used to replace the hAGRP Arg-Phe-Phe residues in the "mini"-AGRP (hAGRP87-120, C105A) template, a potent nanomolar agonist resulted at the mMC1R and MC3-5Rs.	Histidine	22-25	agouti related neuropeptide	Homo sapiens	71-76
15073296-4	2004	Chemical stability analysis and site-directed mutagenesis implicated the highly conserved residues His(395) and Asp(54) as the sites of phosphorylation in DevS and DevR, respectively.	Histidine	99-102	two component transcriptional regulator DevR	Mycobacterium tuberculosis H37Rv	164-168
14672929-12	2004	The simulation offers insight into why Sdh4p Cys-78 may be serving as the second axial ligand for the heme instead of a histidine residue.	Histidine	120-129	succinate dehydrogenase membrane anchor subunit SDH4	Saccharomyces cerevisiae S288C	39-44
14672943-0	2004	Identification of crucial histidines for heme binding in the N-terminal domain of the heme-regulated eIF2alpha kinase.	Histidine	26-36	eukaryotic translation initiation factor 2A	Homo sapiens	101-110
17191848-1	2004	Although both the structures and the reactions of histidine and phenylalanine ammonia lyases (HAL and PAL) are very similar, the former shows a primary kinetic deuterium (D) isotope effect, while the latter does not.	Histidine	50-59	histidine ammonia-lyase	Homo sapiens	94-97
22896902-0	2004	Evidence for the presence of a critical histidine residue at the active site in glyceraldehyde-3-phosphate dehydrogenase of Ehrlich ascites carcinoma cells.	Histidine	40-49	glyceraldehyde-3-phosphate dehydrogenase	Mus musculus	80-120
22896902-5	2004	Statistical analysis of the residual enzyme activity and the extent of modification indicated modification of one essential histidine residue to be responsible for loss of the catalytic activity of EAC cell GA3PD.	Histidine	124-133	glyceraldehyde-3-phosphate dehydrogenase	Mus musculus	207-212
14583620-4	2004	Sequence analysis showed that Dub-1A encodes a 468-amino acid protein that has a molecular mass of approximately 51 kDa and that contains a putative catalytic domain (Cys, His, and Asp) conserved among DUB proteins.	Histidine	172-175	ubiquitin specific peptidase 17-like B	Mus musculus	30-36
14593094-5	2004	The first probe incorporated a photolabile p-benzoyl-l-phenylalanine into the position of His(1) of rat secretin ([Bpa(1),Tyr(10)]secretin-27).	Histidine	90-93	secretin	Rattus norvegicus	104-112
14593094-5	2004	The first probe incorporated a photolabile p-benzoyl-l-phenylalanine into the position of His(1) of rat secretin ([Bpa(1),Tyr(10)]secretin-27).	Histidine	90-93	secretin	Rattus norvegicus	130-138
14711628-6	2004	The OmpT variants with leucine and histidine at position 97 were useful in releasing human adrenocorticotropic hormone (1-24) (serine at the N terminus) and human calcitonin precursor (cysteine at the N terminus), respectively, from fusion proteins.	Histidine	35-44	outer membrane protease	Escherichia coli	4-8
14563830-5	2004	The typical HPGG motif of the cytochrome b5-like domain, and particularly histidine in this motif, is required for the activity of the enzyme, whatever the substrate.	Histidine	74-83	cytochrome b5 type A	Rattus norvegicus	30-43
14686842-2	2003	The syn coordination of histidine residues at the active sites of several carboxylate-rich non-heme diiron enzymes has been difficult to reproduce with small molecule model compounds.	Histidine	24-33	synemin	Homo sapiens	4-7
14530264-1	2003	Neuroglobin and cytoglobin reversibly bind oxygen in competition with the distal histidine, and the observed oxygen affinity therefore depends on the properties of both ligands.	Histidine	81-90	neuroglobin	Homo sapiens	0-11
14638781-4	2003	Only one of the two conserved histidine residues required for cathepsin B exopeptidase activity is predicted to be present.	Histidine	30-39	cathepsin B	Ovis aries	62-73
14965763-2	2003	Several CART peptides that contain multiple disulfide bonds were produced by overexpression in Escherichia coli bacteria as fusion products with a C-terminal histidine tag.	Histidine	158-167	CART prepropeptide	Rattus norvegicus	8-12
14673502-7	2003	So it is demonstrated for the first time that Ser(168) and His(169) or Thr(359)in xGATA-1b may be one of the structural basis for explanting the different function between xGATA-1b and xGATA-1a.	Histidine	59-62	GATA binding protein 1 S homeolog	Xenopus laevis	172-180
14578150-7	2003	For XRCC1 codon 280 genotypes of Arg/His and His/His compared with the Arg/Arg genotype, the OR was 0.64 (95% CI, 0.43-0.96).	Histidine	37-40	X-ray repair cross complementing 1	Homo sapiens	4-9
14519125-6	2003	Affinity purification of histidine-tagged eIF3k from transiently transfected COS cells copurifies other eIF3 subunits.	Histidine	25-34	eukaryotic translation initiation factor 3 subunit A	Homo sapiens	42-46
12963343-3	2003	The expression of N-terminal His(6)-tagged Pwo dUTPase was performed in E. coli BL21(DE3)pLysS and E. coli Rosetta(DE3)pLysS strain that contains plasmid encoding additional copies of rare E. coli tRNAs.	Histidine	29-32	Deoxyuridine triphosphatase	Drosophila melanogaster	47-54
12794073-7	2003	A molecular model of DmPBGS suggests that the inhibitory zinc is located at a subunit interface using Cys-219 and His-10 as ligands.	Histidine	114-117	Porphobilinogen synthase	Drosophila melanogaster	21-27
12764157-1	2003	We mutated residues Met345 and Thr349 in the rat gamma-aminobutyric acid transporter-1 (GAT-1) to histidines (M345H and T349H).	Histidine	98-108	solute carrier family 6 member 12	Rattus norvegicus	49-93
12874010-7	2003	Re(I)-BBN conjugates were prepared by the reaction of [Re(Br)(3)(CO)(3)](2-) and Dpr-Ser-Ser-Ser-Gln-Trp-Ala-Val-Gly-His-Leu-Met-(NH(2)) with gentle heating.	Histidine	117-120	gastrin releasing peptide	Homo sapiens	6-9
12836044-4	2003	The signal is then transferred via histidine-containing phosphotransfer factors, AHPs, to transcription-factor-type response regulators, such as ARR1, which execute the signal-dependent transactivation of primary cytokinin-responsive genes, including those for other types of response regulator.	Histidine	35-44	response regulator 1	Arabidopsis thaliana	145-149
12733060-4	2003	In this work, we demonstrated that the NFO3 gene is identical to OLE1 and that the nfo3-1 mutation (renamed ole1-101) alters arginine-346, in the vicinity of the conserved histidine-rich motif essential for the catalytic function of the Ole1 protein, to lysine.	Histidine	172-181	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	108-112
12595535-10	2003	We show that a completely inactive tyrosinase point mutant lacking a critical histidine residue involved in copper binding is nevertheless able to exit from the ER and undergo further processing.	Histidine	78-87	tyrosinase	Homo sapiens	35-45
12817480-6	2003	In the present study we have overexpressed the human meprin alpha subunit and a His-tagged soluble tail-switch-mutant of meprin beta in Baculovirus-infected insect cells.	Histidine	80-83	meprin A subunit beta	Homo sapiens	121-132
12643901-3	2003	The SAR of the amino acid indicates that the carboxylic acid is required for inhibition and that L-histidine is the most favored amino acid.	Histidine	97-108	sarcosine dehydrogenase	Homo sapiens	4-7
12486123-1	2003	Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta.	Histidine	75-78	cytidine/uridine monophosphate kinase 1	Bos taurus	21-25
12486123-11	2003	We conclude that NDPK B forms complexes with Gbetagamma dimers and contributes to G protein activation by increasing the high energetic phosphate transfer onto GDP via intermediately phosphorylated His-266 in Gbeta(1) subunits.	Histidine	198-201	cytidine/uridine monophosphate kinase 1	Bos taurus	17-21
12501240-9	2003	Individual mutation of His-64, His-228, or His-352 in GIRK4 abolished or greatly diminished the inhibition in homomeric GIRK4.	Histidine	23-26	potassium inwardly rectifying channel subfamily J member 5	Homo sapiens	54-59
12471029-4	2003	Ribonuclease protection assays revealed that one of these splice variants, RyR3 (AS-8a), which lacks a 29-amino acid fragment (His(4406)-Lys(4434)) encompassing a predicted transmembrane helix, was highly expressed in smooth muscle tissues, but not in skeletal muscle, the heart, or the brain.	Histidine	127-130	ryanodine receptor 3	Homo sapiens	75-79
12589497-6	2003	To obtain the methylmalonyl-CoA mutase which was required as a reagent for the assay, an Escherichia coli strain was constructed that expressed high levels of this enzyme as a fusion protein with an 8x histidine tag.	Histidine	202-211	methylmalonyl-CoA mutase	Homo sapiens	14-38
12561067-6	2003	39.5% (15/38) of point mutations were CGT (Arg) to CAT (His) mutation at codon-273 of exon-8.	Histidine	56-59	UDP glycosyltransferase 8	Homo sapiens	38-41
12534280-8	2003	In the high-spin form of NP2, the proximal histidine plane is shown to be oriented 135 degrees clockwise from the heme N(II)-Fe-N(IV) axis, again for the B heme orientation.	Histidine	43-52	neuropilin 2	Homo sapiens	25-28
12564680-5	2003	Cu(II)-IMAC selection of histidine-containing peptides from standard peptide mixtures and protein digests followed by reversed-phase chromatography of the selected peptides was demonstrated in the electrochromatography mode.	Histidine	25-34	C-C motif chemokine ligand 26	Homo sapiens	0-11
12524347-2	2002	We show that SU(VAR)3-9 is a chromatin-associated protein and identify the large multicopy histone gene cluster (HIS-C) as one of its target loci.	Histidine	113-116	Suppressor of variegation 3-9	Drosophila melanogaster	13-23
12524347-3	2002	The organization of nucleosomes over the entire HIS-C region is altered in Su(var)3-9 mutants and there is a concomitant increase in expression of the histone genes.	Histidine	48-51	Suppressor of variegation 3-9	Drosophila melanogaster	75-85
12524347-4	2002	SU(VAR)3-9 is a histone H3 methyltransferase and, using chromatin immunoprecipitation, we show that SU(VAR)3-9 is present at the HIS-C locus and that the histone H3 at the HIS-C locus is methylated.	Histidine	129-132	Suppressor of variegation 3-9	Drosophila melanogaster	0-10
12524347-4	2002	SU(VAR)3-9 is a histone H3 methyltransferase and, using chromatin immunoprecipitation, we show that SU(VAR)3-9 is present at the HIS-C locus and that the histone H3 at the HIS-C locus is methylated.	Histidine	129-132	Suppressor of variegation 3-9	Drosophila melanogaster	100-110
12524347-4	2002	SU(VAR)3-9 is a histone H3 methyltransferase and, using chromatin immunoprecipitation, we show that SU(VAR)3-9 is present at the HIS-C locus and that the histone H3 at the HIS-C locus is methylated.	Histidine	172-175	Suppressor of variegation 3-9	Drosophila melanogaster	0-10
12524347-4	2002	SU(VAR)3-9 is a histone H3 methyltransferase and, using chromatin immunoprecipitation, we show that SU(VAR)3-9 is present at the HIS-C locus and that the histone H3 at the HIS-C locus is methylated.	Histidine	172-175	Suppressor of variegation 3-9	Drosophila melanogaster	100-110
12524347-5	2002	We propose that SU(VAR)3-9 is involved in packaging HIS-C into a distinct chromatin domain that has some of the characteristics of beta-heterochromatin.	Histidine	52-55	Suppressor of variegation 3-9	Drosophila melanogaster	16-26
12589073-6	2002	The Arabidopsis CRE1 histidine kinase and its related proteins AHK2 and AHK3 perceive cytokinins in the environment and transduce a signal, presumably through the AHP bridge components that carry the histidine-containing phosphotransfer (HPt) domain, to the ARR1 response regulator that transcriptionally activates genes immediately responsive to cytokinins.	Histidine	21-30	histidine kinase 2	Arabidopsis thaliana	63-67
12589073-6	2002	The Arabidopsis CRE1 histidine kinase and its related proteins AHK2 and AHK3 perceive cytokinins in the environment and transduce a signal, presumably through the AHP bridge components that carry the histidine-containing phosphotransfer (HPt) domain, to the ARR1 response regulator that transcriptionally activates genes immediately responsive to cytokinins.	Histidine	21-30	response regulator 1	Arabidopsis thaliana	258-262
12213808-0	2002	N-terminal sequence and distal histidine residues are responsible for pH-regulated cytoplasmic membrane binding of human AMP deaminase isoform E. Mammalian AMP deaminase 3 (AMPD3) enzymes reportedly bind to intracellular membranes, plasma lipid vesicles, and artificial lipid bilayers with associated alterations in enzyme conformation and function.	Histidine	31-40	adenosine monophosphate deaminase 3	Homo sapiens	156-171
12213808-0	2002	N-terminal sequence and distal histidine residues are responsible for pH-regulated cytoplasmic membrane binding of human AMP deaminase isoform E. Mammalian AMP deaminase 3 (AMPD3) enzymes reportedly bind to intracellular membranes, plasma lipid vesicles, and artificial lipid bilayers with associated alterations in enzyme conformation and function.	Histidine	31-40	adenosine monophosphate deaminase 3	Homo sapiens	173-178
12213808-8	2002	Finally, AMPD1 and a series of N-truncated AMPD3 enzymes are used to show that these behaviors are specific to isoform E and require up to 48 N-terminal amino acids, even though this stretch of sequence contains no histidine residues.	Histidine	215-224	adenosine monophosphate deaminase 3	Homo sapiens	43-48
12194980-7	2002	Studies with recombinant V5-His-tagged FLRG protein confirm a direct interaction between mature myostatin and FLRG.	Histidine	28-31	follistatin-like 3	Mus musculus	39-43
12194980-7	2002	Studies with recombinant V5-His-tagged FLRG protein confirm a direct interaction between mature myostatin and FLRG.	Histidine	28-31	follistatin-like 3	Mus musculus	110-114
12145299-3	2002	Pho2 + Swi5 activates HO, Pho2 + Pho4 activates PHO5, and Pho2 + Bas1 activates genes in the purine and histidine biosynthesis pathways.	Histidine	104-113	DNA-binding transcription factor SWI5	Saccharomyces cerevisiae S288C	7-11
12145299-3	2002	Pho2 + Swi5 activates HO, Pho2 + Pho4 activates PHO5, and Pho2 + Bas1 activates genes in the purine and histidine biosynthesis pathways.	Histidine	104-113	phosphate-sensing transcription factor PHO4	Saccharomyces cerevisiae S288C	33-37
12217858-1	2002	We purified His-tagged ROMK1 and carried out in vitro phosphorylation assays with (32)P-radiolabeled ATP to determine whether ROMK1 protein is a substrate for PTK.	Histidine	12-15	potassium inwardly-rectifying channel, subfamily J, member 1	Rattus norvegicus	23-28
12215545-6	2002	NIF-1 is a 1,342-amino-acid nuclear protein containing a number of conserved domains, including six Cys-2/His-2 zinc fingers, an N-terminal stretch of acidic amino acids, and a C-terminal leucine zipper-like motif.	Histidine	106-109	zinc finger protein 335	Homo sapiens	0-5
12082110-2	2002	VN also interacts with two-chain high molecular weight kininogen (HKa), particularly its His-Gly-Lys-rich domain 5, and both HKa and PAI-1 are antiadhesive factors that have been shown to compete for binding to VN.	Histidine	89-92	vitronectin	Homo sapiens	0-2
12221648-2	2002	We found that divalent metal Zn2+ can improve the polyfection efficiency, especially with DNA/histidylated polylysine (His-pLK) complexes.	Histidine	119-122	polo like kinase 1	Homo sapiens	123-126
12221648-4	2002	Zn2+ is more efficient on DNA/His-pLK complexes: the number of EGFP-positive cells increased from 1% to more than 40%.	Histidine	30-33	polo like kinase 1	Homo sapiens	34-37
12221648-8	2002	Flow cytometry and confocal microscopy studies clearly indicate that with His-pLK, the plasmid is better delivered in the cytosol as well as in the cell nucleus in zinc-treated cells.	Histidine	74-77	polo like kinase 1	Homo sapiens	78-81
12077146-3	2002	We introduced histidines into sites located in the second and third putative extracellular loops of CXCR1, creating single, double, and triple mutant receptors: R199H, R203H, D265H, R199H/R203H, R199H/D265H, R203H/D265H, R203H/H207Q, and R199H/R203H/D265H.	Histidine	14-24	C-X-C motif chemokine receptor 1	Homo sapiens	100-105
12077146-6	2002	On the other hand, cells expressing all single, double, or triple histidine-substituted CXCR1 demonstrated high affinity binding to interleukin 8 in the presence and absence of metal ions.	Histidine	66-75	C-X-C motif chemokine receptor 1	Homo sapiens	88-93
12145341-7	2002	Conversely, the substitution of Y614 of the rFSHR with the cognate hFSHR residue (histidine) fully suppresses the constitutive activity of the rFSHR (D580G) mutant.	Histidine	82-91	follicle stimulating hormone receptor	Homo sapiens	67-72
12205739-4	2002	alphaMSH analogues [(6)His]alphaMSH-ND and [(6)Asn]alphaMSH-ND were synthesized and the radio-ligand receptor binding- and cyclic AMP generating activity were analyzed in China Hamster Ovary cell line over- expressing melanocortin receptors.	Histidine	23-26	proopiomelanocortin	Rattus norvegicus	0-8
12205739-5	2002	The EC(50) of [(6)His]alphaMSH-ND measured from melanocortin-1, 3, 4 and 5 receptors were 0.008 +/- 0.0045, 1.523 +/- 0.707, 0.780 +/- 0.405, and 250.320 +/- 42.234 nM, respectively, and the EC(50) of [(6)Asn]alphaMSH-ND were 16.8 +/- 6.94, 271.8 +/- 21.95, 8.0 +/- 1.21, and 1132.5 +/- 635.46 nM, respectively.	Histidine	18-21	proopiomelanocortin	Rattus norvegicus	22-30
12135746-4	2002	Upon binding to this site, which involves a histidine inserted in position 310 (V310H) and the endogenous Cys306 within the same DAT molecule, Zn(2+) potently inhibits [(3)H]dopamine uptake.	Histidine	44-53	solute carrier family 6 member 3	Homo sapiens	129-132
12102635-8	2002	However, the cDNA of platelet CKIIalpha has a different amino acid at position 236 (Arg --&gt; His), which is not found in the intronless gene.	Histidine	95-98	casein kinase 2 alpha 2	Homo sapiens	30-39
12082127-4	2002	It has been proposed that this species specificity of the hGHR is largely caused by the Leu --&gt; Arg change at position 43 after a prior His --&gt; Asp change at position 171 of the GH.	Histidine	139-142	growth hormone receptor	Homo sapiens	58-62
12065604-5	2002	Analysis of the K (i) of recombinant His-tagged rat cystatin E/M toward cathepsins B and H revealed that rat cystatin E/M has an inhibitor profile distinct from that of other members of the cystatin family.	Histidine	37-40	cystatin E/M	Homo sapiens	52-62
12065604-5	2002	Analysis of the K (i) of recombinant His-tagged rat cystatin E/M toward cathepsins B and H revealed that rat cystatin E/M has an inhibitor profile distinct from that of other members of the cystatin family.	Histidine	37-40	cystatin E/M	Homo sapiens	109-119
12055292-2	2002	The predicted protein of 512 aa shared 53% sequence identity with the two fatty acid Delta9-desaturases, ole1p and ole2p, already described in this organism and contained three histidine boxes, four putative transmembrane domains and a C-terminal cytochrome b(5) fusion that are typical of most fungal membrane-bound fatty acid desaturases.	Histidine	177-186	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	105-110
12028580-0	2002	Molecular anatomy of tyrosinase and its related proteins: beyond the histidine-bound metal catalytic center.	Histidine	69-78	tyrosinase	Homo sapiens	21-31
11884405-3	2002	In this study, we probed the functional properties of two histidines (His-120 and His-122) and a tyrosine (Tyr-168) postulated to be important in the mechanism of AANAT based on prior x-ray structural and biochemical studies.	Histidine	58-68	aralkylamine N-acetyltransferase	Homo sapiens	163-168
11884405-3	2002	In this study, we probed the functional properties of two histidines (His-120 and His-122) and a tyrosine (Tyr-168) postulated to be important in the mechanism of AANAT based on prior x-ray structural and biochemical studies.	Histidine	70-73	aralkylamine N-acetyltransferase	Homo sapiens	163-168
11884405-4	2002	Using a combination of steady-state kinetic measurements of microviscosity effects and pH dependence on the H122Q, H120Q, and H120Q/H122Q AANAT mutants, we show that His-122 (with an apparent pK(a) of 7.3) contributes approximately 6-fold to the acetyltransferase chemical step as either a remote catalytic base or hydrogen bond donor.	Histidine	166-169	aralkylamine N-acetyltransferase	Homo sapiens	138-143
11988102-6	2002	We took advantage of the functionality of the purified material to (i) develop an efficient surface-plasmon resonance assay of the interaction between two calcium channel subunits and (ii) measure, for the first time, the affinity of the recombinant His-beta(4) subunit for the full-length Ca(v)2.1 channel.	Histidine	250-253	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit S homeolog	Xenopus laevis	290-298
11978727-3	2002	Based on sequence analysis, Png1p was classified as a member of the "transglutaminase-like superfamily" that contains a putative catalytic triad of amino acids (cysteine, histidine, and aspartic acid).	Histidine	171-180	peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase	Saccharomyces cerevisiae S288C	28-33
11966977-6	2002	For these peptides, the affinity and activity at all three human receptors (MC3R, MC4R and MC5R) decreased significantly, demonstrating that the His-Phe-Arg-Trp sequence in gamma-MSH is important for activity at these three melanocortin receptors.	Histidine	145-148	melanocortin 5 receptor	Homo sapiens	91-95
11939775-8	2002	Like Co(2+), Fe(2+) bound to yeast ferrochelatase was coordinated by approximately six oxygen or nitrogen ligands, again with evidence of two histidine ligands.	Histidine	142-151	ferrochelatase	Mus musculus	35-49
11812789-4	2002	Cys-191, His-218, and Asp-235 of Png1p are conserved in the sequence of factor XIIIa, where these amino acids constitute a catalytic triad.	Histidine	9-12	peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase	Saccharomyces cerevisiae S288C	33-38
11799105-3	2002	The three-dimensional structure of NAT from Salmonella typhimurium has been resolved and shown to have three distinct domains and an active site catalytic triad composed of "Cys(69)-His(107)-Asp(122)," which is typical of hydrolytic enzymes such as the cysteine proteases.	Histidine	182-185	bromodomain containing 2	Homo sapiens	35-38
11884629-0	2002	Involvement of conserved histidine, lysine and tyrosine residues in the mechanism of DNA cleavage by the caspase-3 activated DNase CAD.	Histidine	25-34	caspase 3	Mus musculus	105-114
11895450-1	2002	Histidine ammonia-lyase (EC 4.3.1.3) catalyzes the nonoxidative elimination of the alpha-amino group of histidine using a 4-methylidene-imidazole-5-one (MIO), which is formed autocatalytically from the internal peptide segment 142Ala-Ser-Gly.	Histidine	104-113	histidine ammonia-lyase	Homo sapiens	0-23
11741986-7	2002	The sequence of the protease domain carried the essential triad His, Asp, and Ser and showed some similarity to that of TMPRSS2, hepsin, HAT, MT-SP1, TMPRSS3, and corin, sharing 45.5, 41.9, 41.3, 40.3, 39.1, and 38.5% identity, respectively.	Histidine	64-67	hepsin	Homo sapiens	129-135
11802791-1	2002	The ability of the lysosomal cysteine protease cathepsin B to function as a peptidyldipeptidase (removing C-terminal dipeptides) has been attributed to the presence of two histidine residues (His(110) and His(111)) present in the occluding loop, an extra peptide segment located in the primed side of the active-site cleft.	Histidine	172-181	cathepsin B	Homo sapiens	47-58
11802791-1	2002	The ability of the lysosomal cysteine protease cathepsin B to function as a peptidyldipeptidase (removing C-terminal dipeptides) has been attributed to the presence of two histidine residues (His(110) and His(111)) present in the occluding loop, an extra peptide segment located in the primed side of the active-site cleft.	Histidine	192-195	cathepsin B	Homo sapiens	47-58
11802791-1	2002	The ability of the lysosomal cysteine protease cathepsin B to function as a peptidyldipeptidase (removing C-terminal dipeptides) has been attributed to the presence of two histidine residues (His(110) and His(111)) present in the occluding loop, an extra peptide segment located in the primed side of the active-site cleft.	Histidine	205-208	cathepsin B	Homo sapiens	47-58
11815678-6	2002	It is speculated that the site-specific inactivation of TPO might have occurred at the heme-linked histidine residue of the TPO molecule, a critical amino acid for enzyme activity because OH* (vicious free radicals) can be formed at the iron-linked amino acid.	Histidine	99-108	thyroid peroxidase	Homo sapiens	56-59
11815678-6	2002	It is speculated that the site-specific inactivation of TPO might have occurred at the heme-linked histidine residue of the TPO molecule, a critical amino acid for enzyme activity because OH* (vicious free radicals) can be formed at the iron-linked amino acid.	Histidine	99-108	thyroid peroxidase	Homo sapiens	124-127
22896886-1	2002	Wheat germ lipase (WGL) was inactivated by chemical modification of histidine, serine and carboxyl groups of Asp/Glu residues with diethyl pyrocarbonate (DEPC), phenyl methyl sulfonyl fluoride (PMSF) and 1-ethyl-3-(3-dimethylaminopropyl) carbodi-imide (EDC), respectively.	Histidine	68-77	probable feruloyl esterase A	Triticum aestivum	11-17
11841570-5	2002	Their rank order of potency in P2X4 and P2X7 receptors was carnosine = PA = His &gt; BPh &gt; Glycine (Gly) and carnosine = BPh = His &gt; PA &gt; Gly, respectively.	Histidine	76-79	purinergic receptor P2X 4	Rattus norvegicus	31-35
11841570-6	2002	The potency to prevent the zinc-induced potentiation in the P2X4 receptor was BPh &gt; PA &gt; His; carnosine, Gly and beta-alanine were inactive.	Histidine	95-98	purinergic receptor P2X 4	Rattus norvegicus	60-64
11850543-5	2002	All MRT samples had missense mutations in the human KRT 8 gene, i.e., Arg89 --&gt; Cys (5/7); Arg --&gt; Cys251 (3/7); Glu267 --&gt; Lys (6/7); Ser290 --&gt; Ile, Met; (7/7) and Arg301 --&gt; His(4/7), none of which was detected in any control samples.	Histidine	192-195	keratin 8	Homo sapiens	52-57
11731079-4	2001	The predicted protein sequence displayed extensive similarity to that of known MMP-9s and contained a putative signal sequence, a propeptide, an active site with three zinc-binding histidine residues, a calcium-binding domain, a hemopexin region, and three key cysteine residues.	Histidine	181-190	matrix metallopeptidase 9	Canis lupus familiaris	79-84
11481322-4	2001	Direct physical interactions between the N- and C-zinc finger domains of GATA-4 and the cysteine/histidine-rich region 3 (C/H3) of p300 were identified in immunoprecipitation and glutathione S-transferase pull-down experiments.	Histidine	97-106	E1A binding protein p300	Mus musculus	131-135
11564711-3	2001	To protect from DPP IV, we have studied the biological activity of a GLP-1 analog in which 6-aminohexanoic acid (Aha) is inserted between histidine and alanine at positions 7 and 8.	Histidine	138-147	glucagon	Rattus norvegicus	69-74
11527429-6	2001	S100A4 had a greater affinity for wild-type or mutant arg-175-his p53 than for non-muscle myosin.	Histidine	62-65	S100 calcium binding protein A4	Homo sapiens	0-6
11561725-4	2001	The sequences around the proposed active site Asp, His, and Ser residues of KpcA are similar to those of other Kex2p family members.	Histidine	51-54	kexin KEX2	Saccharomyces cerevisiae S288C	111-116
11488596-0	2001	Disruption of histidine catabolism in NEUT2 mice.	Histidine	14-23	aldehyde dehydrogenase 1 family, member L1	Mus musculus	38-43
11488913-5	2001	Bacterially expressed chicken IL-6 (ChIL-6) carrying a histidine tag in place of the signal peptide was biologically active: it induced proliferation of the IL-6-dependent murine hybridoma cell line 7TD1.	Histidine	55-64	interleukin 6	Gallus gallus	30-34
11488913-5	2001	Bacterially expressed chicken IL-6 (ChIL-6) carrying a histidine tag in place of the signal peptide was biologically active: it induced proliferation of the IL-6-dependent murine hybridoma cell line 7TD1.	Histidine	55-64	interleukin 6	Gallus gallus	36-42
11488913-5	2001	Bacterially expressed chicken IL-6 (ChIL-6) carrying a histidine tag in place of the signal peptide was biologically active: it induced proliferation of the IL-6-dependent murine hybridoma cell line 7TD1.	Histidine	55-64	interleukin 6	Gallus gallus	38-42
11463578-13	2001	Determining the tertiary structure of 3beta-HSD/isomerase will clarify the mechanistic roles of potentially critical amino acids (His(261), Tyr(253)) that have been identified in the primary structure.	Histidine	130-133	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	38-47
11415439-2	2001	They contain two and three thioredoxin boxes (Cys-Gly-His-Cys) respectively and, like PDI, may be involved in the folding of nascent proteins.	Histidine	54-57	prolyl 4-hydroxylase subunit beta	Rattus norvegicus	86-89
11278563-3	2001	Tankyrase 2 is a 130-kDa protein, which lacks the N-terminal histidine/proline/serine-rich region of tankyrase, but contains a corresponding ankyrin repeat region, sterile alpha motif module, and poly(ADP-ribose) polymerase homology domain.	Histidine	61-70	tankyrase 2	Homo sapiens	0-11
11336635-9	2001	Recombinant rPHT2 protein reconstituted into liposomes showed proton-dependent transport activity with histidine and histidyl-leucine.	Histidine	103-112	solute carrier family 15 member 3	Rattus norvegicus	12-17
11320329-0	2001	Post-translational modification of the N-terminal His tag interferes with the crystallization of the wild-type and mutant SH3 domains from chicken src tyrosine kinase.	Histidine	50-53	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	147-150
11300772-4	2001	Moreover, DEPC inactivates cytochrome b(561) more rapidly at alkaline pH, consistent with modification of a histidine residue.	Histidine	108-117	mitochondrially encoded cytochrome b	Homo sapiens	27-39
11250654-4	2001	Our data revealed that full-length IGFBP-4 peptides lacking the residues Leu(72)-Ser(91) or Leu(72)-His(74) or Gly(75)-Ser(91) failed to bind to IGF-I or IGF-II, whereas deletion of the residue Leu(72) or residues Met(80)-Ser(91) led to a 2- to 3-fold reduction in IGF-I and IGF-II binding activity.	Histidine	100-103	insulin like growth factor binding protein 4	Homo sapiens	35-42
11289130-3	2001	Resistance to this peptide and another toxic peptide derivative, which is based on a Thr-His-Thr-Nle-Glu-Gly backbone conjugated to butyl and benzyl groups (4A6), could be reversed by MRP1 inhibitors.	Histidine	89-92	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	Mus musculus	184-188
11239577-4	2001	The first three-dimensional structure of the unique NAT family shows the active-site cysteine to be aligned with conserved histidine and aspartate residues to form a catalytic triad, thus providing an activation mechanism for transfer of the acetyl group from acetyl CoA to cysteine.	Histidine	123-132	bromodomain containing 2	Homo sapiens	52-55
11327835-1	2001	Histidine 64 in human carbonic anhydrase II (HCA II) functions in the catalytic pathway of CO(2) hydration as a shuttle to transfer protons between the zinc-bound water and bulk water.	Histidine	0-9	carbonic anhydrase 2	Homo sapiens	22-43
11319928-5	2001	The large putative Rep protein encoded by pME2001 was overexpressed in Escherichia coli as an N-terminal His-tagged version using pET28a and a compatible helper plasmid that coexpresses minor tRNAs, argU and ileX to compensate for codon usage difference.	Histidine	105-108	replication protein	Escherichia coli	19-22
11137123-2	2000	The cDNA of equine IL2 or IL4 was cloned in a mammalian expression vector, containing c-terminal myc- and six histidines His(6)-epitopes for recognition and purification of equine cytokines.	Histidine	110-120	interleukin 2	Equus caballus	19-22
11082534-4	2000	In the present paper, the murine ADRP has been expressed as a recombinant histidine-tagged protein in Escherichia coli, and purified from expressing cultures in order to examine its biochemical properties.	Histidine	74-83	perilipin 2	Mus musculus	33-37
11063596-1	2000	The alkaline conformational transition of a lysine 73 --&gt; histidine variant of iso-1-cytochrome c has been studied.	Histidine	61-70	eukaryotic translation initiation factor 1	Homo sapiens	82-87
10992296-7	2000	The hBUB1 gene of one adenocarcinoma tumor contained a somatic missense mutation, a cytosine-to-guanine substitution in codon 51 of exon 5 that resulted in a histidine-to-aspartic acid amino acid substitution.	Histidine	158-167	BUB1 mitotic checkpoint serine/threonine kinase	Homo sapiens	4-9
11041873-5	2000	The mMCP-6 fusion protein contained an N-terminal 6 x His tag followed by an enterokinase (EK) site replacing the native activation peptide (6xHis-EK-mMCP-6).	Histidine	54-57	tryptase beta 2	Mus musculus	4-10
11005799-6	2000	The first three-dimensional structure of a member of the NAT family identifies a catalytic triad consisting of aspartate, histidine and cysteine proposed to form the activation mechanism.	Histidine	122-131	bromodomain containing 2	Homo sapiens	57-60
11054275-4	2000	Bacterially expressed ChIL-18 in which the N-terminal 29 amino acids of the putative precursor molecule were replaced by a histidine tag induced the synthesis of interferon-gamma (IFN-gamma) in cultured primary chicken spleen cells, indicating that the recombinant protein is biologically active.	Histidine	123-132	interferon gamma	Gallus gallus	162-178
11054275-4	2000	Bacterially expressed ChIL-18 in which the N-terminal 29 amino acids of the putative precursor molecule were replaced by a histidine tag induced the synthesis of interferon-gamma (IFN-gamma) in cultured primary chicken spleen cells, indicating that the recombinant protein is biologically active.	Histidine	123-132	interferon gamma	Gallus gallus	180-189
10985787-2	2000	The binding of E12 was localized to the N-terminal, regulatory domain of VanR which contains Asp-55, the residue which accepts the phosphoryl group from His-164 in the activated VanS sensor kinase.	Histidine	153-156	VanR	Enterococcus faecium	73-77
10986467-6	2000	The proximal and distal histidine sidechains coordinate directly to the heme iron, forming a hemichrome with spectral properties similar to those of cytochrome b(5).	Histidine	24-33	mitochondrially encoded cytochrome b	Homo sapiens	149-161
10773212-4	2000	The radioactivity of the aqueduct was also higher in the 65Zn-His group, indicating that CSF clearance of the 65Zn-His group may be lower than that of the 65ZnCl(2) group.	Histidine	62-65	colony stimulating factor 2	Rattus norvegicus	89-92
10773212-5	2000	These results suggest an enhancement by histidine on zinc uptake in the brain parenchyma via the CSF.	Histidine	40-49	colony stimulating factor 2	Rattus norvegicus	97-100
10766853-9	2000	The caspase inhibitors carbobenzoxy-Leu-Glu-His-Asp-CH(2)F and carbobenzoxy-Asp-Glu-Val-Asp-CH(2)F, but not carbobenzoxy-Ile-Glu-Thr-Asp-CH(2)F, differentially blocked post-mitochondrial events.	Histidine	44-47	caspase 8	Rattus norvegicus	4-11
10727410-10	2000	The modifications at His(111) (H111A) and His(110) (H110A) of cathepsin B led to an increase in k(cat) values of one or two orders of magnitude.	Histidine	21-24	cathepsin B	Homo sapiens	62-73
10699485-1	2000	Glucagon-like peptide-1(7-36)amide (tGLP-1) is inactivated by dipeptidyl peptidase (DPP) IV by removal of the NH(2)-terminal dipeptide His(7)-Ala(8).	Histidine	135-138	glucagon	Rattus norvegicus	0-23
10719389-2	2000	A pancreatic hydrolysate of casein (trypticase peptone, 0.1 mg/ml) and some amino acids (cysteine, tryptophan and methionine, 50 microM each) also inhibited the TPO iodide oxidation reaction completely, whereas casamino acids (0.1 mg/ml), and tyrosine, phenylalanine and histidine (50 microM each) inhibited the TPO reaction by 54% or less.	Histidine	271-280	thyroid peroxidase	Homo sapiens	161-164
10692590-0	2000	Identification of active site serine and histidine residues in Escherichia coli outer membrane protease OmpT.	Histidine	41-50	outer membrane protease	Escherichia coli	104-108
10692590-7	2000	We propose that OmpT is a novel serine protease with Ser(99) as the active site nucleophile and His(212) as general base.	Histidine	96-99	outer membrane protease	Escherichia coli	16-20
10686340-4	2000	As a first step, the conserved cysteine (C) and histidine (H) residues were targeted for site-directed mutagenesis as potential amino acid residues involved in the N-acetylation reaction of AA-NAT.	Histidine	48-57	aralkylamine N-acetyltransferase	Homo sapiens	190-196
10686340-5	2000	Our studies concluded that among 6 histidine (H) to alanine (A) mutations, three residues (H110A, H118A, H120A) within the AA-NAT protein showed little or no enzymatic activity, whereas the others (H28A, H70A, H125A) retained enzymatic activity, compared to the unaltered AA-NAT protein.	Histidine	35-44	aralkylamine N-acetyltransferase	Homo sapiens	123-129
10686340-5	2000	Our studies concluded that among 6 histidine (H) to alanine (A) mutations, three residues (H110A, H118A, H120A) within the AA-NAT protein showed little or no enzymatic activity, whereas the others (H28A, H70A, H125A) retained enzymatic activity, compared to the unaltered AA-NAT protein.	Histidine	35-44	aralkylamine N-acetyltransferase	Homo sapiens	272-278
10672909-4	2000	DPP IV requires an intact alpha-amino-group of the N-terminal histidine of GLP-1 in order to perform its enzymatic activity.	Histidine	62-71	glucagon	Rattus norvegicus	75-80
10631324-2	2000	The N-half of the deduced amino acid sequence of 432 amino acids of CROP contains cysteine/histidine motifs and leucine zipper-like repeats.	Histidine	91-100	LUC7 like 3 pre-mRNA splicing factor	Homo sapiens	68-72
10617633-7	2000	Point mutations of conserved cysteine residues or a histidine in the RING finger domain, which are required for zinc binding, abrogated the ability of Cbl to negatively regulate Syk in COS-7 cells and Ramos B lymphocytic cells.	Histidine	52-61	spleen associated tyrosine kinase	Homo sapiens	178-181
15693279-10	2000	In agreement with this possibility, the A beta peptide reduces less copper in the presence of exogenous histidine.	Histidine	104-113	amyloid beta precursor protein	Rattus norvegicus	40-46
10701841-6	2000	Therefore, both GST-SStp and His-S-SStp can be used as affinity-tagged substrates to study prokaryotic chaperone/transit peptide interactions as well as to provide a novel functional probe to study the dynamics of DnaK/DnaJ/GrpE interactions in vivo.	Histidine	29-32	DnaJ heat shock protein family (Hsp40) member B6	Homo sapiens	219-223
11030070-6	2000	A novel point mutation located in codon 126 of the connexin32 gene, substituting a histidine for a tyrosine, was found in the index patient, in the mother, in two sisters and in a brother.	Histidine	83-92	gap junction protein beta 1	Homo sapiens	51-61
10668803-1	2000	Rpb5-H147R is an AT-GC transition replacing CAC(His) by CGC(Arg) at a conserved and critical position of ABC27 (Rpb5p), one of the five common and essential subunits shared by all three eukaryotic RNA polymerases.	Histidine	48-51	ATP binding cassette subfamily F member 1	Homo sapiens	105-110
10601246-2	1999	Recently, we have described a distance constraint in the unknown tertiary structure of the human dopamine transporter (hDAT) by identification of two histidines, His(193) in the second extracellular loop and His(375) at the top of transmembrane (TM) 7, that form two coordinates in an endogenous, high affinity Zn(2+)-binding site.	Histidine	150-160	solute carrier family 6 member 3	Homo sapiens	97-117
10601246-2	1999	Recently, we have described a distance constraint in the unknown tertiary structure of the human dopamine transporter (hDAT) by identification of two histidines, His(193) in the second extracellular loop and His(375) at the top of transmembrane (TM) 7, that form two coordinates in an endogenous, high affinity Zn(2+)-binding site.	Histidine	150-160	solute carrier family 6 member 3	Homo sapiens	119-123
10601246-2	1999	Recently, we have described a distance constraint in the unknown tertiary structure of the human dopamine transporter (hDAT) by identification of two histidines, His(193) in the second extracellular loop and His(375) at the top of transmembrane (TM) 7, that form two coordinates in an endogenous, high affinity Zn(2+)-binding site.	Histidine	162-165	solute carrier family 6 member 3	Homo sapiens	97-117
10601246-2	1999	Recently, we have described a distance constraint in the unknown tertiary structure of the human dopamine transporter (hDAT) by identification of two histidines, His(193) in the second extracellular loop and His(375) at the top of transmembrane (TM) 7, that form two coordinates in an endogenous, high affinity Zn(2+)-binding site.	Histidine	162-165	solute carrier family 6 member 3	Homo sapiens	119-123
10601246-2	1999	Recently, we have described a distance constraint in the unknown tertiary structure of the human dopamine transporter (hDAT) by identification of two histidines, His(193) in the second extracellular loop and His(375) at the top of transmembrane (TM) 7, that form two coordinates in an endogenous, high affinity Zn(2+)-binding site.	Histidine	208-211	solute carrier family 6 member 3	Homo sapiens	97-117
10601246-2	1999	Recently, we have described a distance constraint in the unknown tertiary structure of the human dopamine transporter (hDAT) by identification of two histidines, His(193) in the second extracellular loop and His(375) at the top of transmembrane (TM) 7, that form two coordinates in an endogenous, high affinity Zn(2+)-binding site.	Histidine	208-211	solute carrier family 6 member 3	Homo sapiens	119-123
10601246-8	1999	The common participation of Glu(396), His(193), and His(375) in binding the small Zn(2+) ion implies their proximity in the unknown tertiary structure of hDAT.	Histidine	38-41	solute carrier family 6 member 3	Homo sapiens	154-158
10601246-8	1999	The common participation of Glu(396), His(193), and His(375) in binding the small Zn(2+) ion implies their proximity in the unknown tertiary structure of hDAT.	Histidine	52-55	solute carrier family 6 member 3	Homo sapiens	154-158
10658591-5	1999	The amino acids found to be important for MDL103,392 binding to the NK-2 receptor are Gln-166, His-198, Tyr-266 and Tyr-289.	Histidine	95-98	tachykinin receptor 2	Homo sapiens	68-81
10578014-25	1999	Mechanisms of H(+) permeation through gp91-phox include the possible protonation/deprotonation of His-115 as it is exposed alternatively to the interior and exterior faces of the cell membrane (see Starace, D.M., E. Stefani, and F. Bezanilla.	Histidine	98-101	cytochrome b-245 beta chain	Homo sapiens	38-47
10525531-6	1999	Recombinant GST-Kap122p formed a complex with recombinant His(6)-Toa1p/Toa2p.	Histidine	58-61	Kap122p	Saccharomyces cerevisiae S288C	16-23
10525531-6	1999	Recombinant GST-Kap122p formed a complex with recombinant His(6)-Toa1p/Toa2p.	Histidine	58-61	transcription initiation factor IIA subunit gamma	Saccharomyces cerevisiae S288C	71-76
10605835-9	1999	The crystal structure of a spectroscopically similar sample of CCP (MKT) (lambda CT = 637 nm) solved at 2.0 A resolution is consistent with His/hydroxide coordination.	Histidine	140-143	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	63-66
10605835-10	1999	Alkaline CCP (pH 9.7) is proposed to exist as a mixture of hexa-coordinate, predominantly low-spin complexes with distal His 52 and hydroxide acting as distal ligands based on MCD spectral comparisons.	Histidine	121-124	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	9-12
10467162-6	1999	A (His)(6)-tagged protein comprising residues 455-511 of PKN (designated His-Ialpha) inhibited the kinase activity of the catalytic fragment of PKN in a concentration-dependent manner in competition with substrate (K(i) = 0.6+/-0.2 microM).	Histidine	3-6	protein kinase N1	Homo sapiens	57-60
10467162-6	1999	A (His)(6)-tagged protein comprising residues 455-511 of PKN (designated His-Ialpha) inhibited the kinase activity of the catalytic fragment of PKN in a concentration-dependent manner in competition with substrate (K(i) = 0.6+/-0.2 microM).	Histidine	3-6	protein kinase N1	Homo sapiens	144-147
10423244-11	1999	It is likely that the behaviors of Tyr residues are controlled by the ligation of beta heme through His-beta 92(F8)--&gt;Val-beta 98(FG5)--&gt;Asp-beta 99(G1 )--&gt;Tyr-alpha 42(C7) or Tyr-beta 145(HC2).	Histidine	100-103	proline rich protein BstNI subfamily 3	Homo sapiens	147-157
10386625-3	1999	After purification by Ni2+ affinity chromatography, His-tagged Ras-binding domain of c-Raf-1 could be isolated in sufficient amounts for biochemical and biophysical investigations.	Histidine	52-55	TNF receptor associated factor 3	Homo sapiens	85-92
10085111-12	1999	Histidine residues at positions 46 and 60 are responsible for heme ligation because the H46N- or H60N-substituted QPs3 fail to restore cytochrome b560 upon addition of hemin chloride.	Histidine	0-9	cytochrome b	Bos taurus	135-147
10233272-6	1999	Here, we report the first mutation in the 2B domain of KRT9, 1362ins3, leading to an insertion of histidine in the helix termination motif of the K9 polypeptide.	Histidine	98-107	keratin 9	Homo sapiens	55-59
10233272-6	1999	Here, we report the first mutation in the 2B domain of KRT9, 1362ins3, leading to an insertion of histidine in the helix termination motif of the K9 polypeptide.	Histidine	98-107	keratin 9	Homo sapiens	146-148
10051312-5	1999	Comparison of mouse PR3 genomic structure with that of its human counterpart indicates that: 1) the mPR3 gene spans 7 kb organized in 5 exons and 4 introns, 2) the codons of His-Asp-Ser of the catalytic site are conserved and spread out over different exons, similar to the human gene, and 3) the gene product encodes a pre-proform of the protein.	Histidine	174-177	proteinase 3	Mus musculus	100-104
10209751-10	1999	Incubation of extracts from Escherichia coli overexpressing His-VirE1 with the extracts of E. coli overexpressing His-VirE2 increased the yield of His-VirE2 in the soluble fraction.	Histidine	60-63	type IV secretion system chaperone VirE1	Agrobacterium tumefaciens	64-69
10209751-10	1999	Incubation of extracts from Escherichia coli overexpressing His-VirE1 with the extracts of E. coli overexpressing His-VirE2 increased the yield of His-VirE2 in the soluble fraction.	Histidine	60-63	type IV secretion system single-stranded DNA binding protein VirE2	Agrobacterium tumefaciens	118-123
10209751-10	1999	Incubation of extracts from Escherichia coli overexpressing His-VirE1 with the extracts of E. coli overexpressing His-VirE2 increased the yield of His-VirE2 in the soluble fraction.	Histidine	60-63	type IV secretion system single-stranded DNA binding protein VirE2	Agrobacterium tumefaciens	151-156
10209751-10	1999	Incubation of extracts from Escherichia coli overexpressing His-VirE1 with the extracts of E. coli overexpressing His-VirE2 increased the yield of His-VirE2 in the soluble fraction.	Histidine	114-117	type IV secretion system chaperone VirE1	Agrobacterium tumefaciens	64-69
10209751-10	1999	Incubation of extracts from Escherichia coli overexpressing His-VirE1 with the extracts of E. coli overexpressing His-VirE2 increased the yield of His-VirE2 in the soluble fraction.	Histidine	114-117	type IV secretion system single-stranded DNA binding protein VirE2	Agrobacterium tumefaciens	118-123
10209751-10	1999	Incubation of extracts from Escherichia coli overexpressing His-VirE1 with the extracts of E. coli overexpressing His-VirE2 increased the yield of His-VirE2 in the soluble fraction.	Histidine	114-117	type IV secretion system single-stranded DNA binding protein VirE2	Agrobacterium tumefaciens	151-156
10209751-10	1999	Incubation of extracts from Escherichia coli overexpressing His-VirE1 with the extracts of E. coli overexpressing His-VirE2 increased the yield of His-VirE2 in the soluble fraction.	Histidine	114-117	type IV secretion system chaperone VirE1	Agrobacterium tumefaciens	64-69
10209751-10	1999	Incubation of extracts from Escherichia coli overexpressing His-VirE1 with the extracts of E. coli overexpressing His-VirE2 increased the yield of His-VirE2 in the soluble fraction.	Histidine	114-117	type IV secretion system single-stranded DNA binding protein VirE2	Agrobacterium tumefaciens	118-123
10209751-10	1999	Incubation of extracts from Escherichia coli overexpressing His-VirE1 with the extracts of E. coli overexpressing His-VirE2 increased the yield of His-VirE2 in the soluble fraction.	Histidine	114-117	type IV secretion system single-stranded DNA binding protein VirE2	Agrobacterium tumefaciens	151-156
10209751-11	1999	In a similar purified protein solubility assay, His-VirE1 increased the amount of His-VirE2 partitioning into the soluble fraction.	Histidine	48-51	type IV secretion system chaperone VirE1	Agrobacterium tumefaciens	52-57
10209751-11	1999	In a similar purified protein solubility assay, His-VirE1 increased the amount of His-VirE2 partitioning into the soluble fraction.	Histidine	48-51	type IV secretion system single-stranded DNA binding protein VirE2	Agrobacterium tumefaciens	86-91
10209751-11	1999	In a similar purified protein solubility assay, His-VirE1 increased the amount of His-VirE2 partitioning into the soluble fraction.	Histidine	82-85	type IV secretion system chaperone VirE1	Agrobacterium tumefaciens	52-57
10209751-11	1999	In a similar purified protein solubility assay, His-VirE1 increased the amount of His-VirE2 partitioning into the soluble fraction.	Histidine	82-85	type IV secretion system single-stranded DNA binding protein VirE2	Agrobacterium tumefaciens	86-91
10193578-9	1999	The effect of the MPO/H2O2/NaNO2 system was prevented by MPO inhibitors (sodium azide, isoniazid, salicylhydroxamic acid) and also by L-cysteine, L-methionine, L-tryptophan, L-tyrosine, L-histidine and reduced glutathione.	Histidine	186-197	myeloperoxidase	Equus caballus	18-21
9895333-0	1999	Posttranslational deamidation of proteins: the case of hemoglobin J Sardegna [alpha50(CD8)His--&gt;Asn--&gt;Asp].	Histidine	90-93	CD8a molecule	Homo sapiens	86-89
9895333-1	1999	Hemoglobin J Sardegna [alpha50(CD8)His--&gt;Asn --&gt;Asp] is a human Hb variant in which a posttranslational deamidation process takes place, transforming an Asn to an Asp residue.	Histidine	35-38	CD8a molecule	Homo sapiens	31-34
10051705-2	1999	Histamine is synthesized by L-histidine, catalysed by L-histidine decarboxylase (HDC) and metabolized mainly by histamine N-methyltransferase (HMT).	Histidine	28-39	histamine N-methyltransferase	Homo sapiens	112-141
10051705-2	1999	Histamine is synthesized by L-histidine, catalysed by L-histidine decarboxylase (HDC) and metabolized mainly by histamine N-methyltransferase (HMT).	Histidine	28-39	histamine N-methyltransferase	Homo sapiens	143-146
10234805-8	1999	An N-cadherin peptidomimic containing the His-Ala-Val sequence to abrogate homotypic N-cadherin interactions inhibited chondrogenesis in a concentration-dependent manner.	Histidine	42-45	cadherin 2	Mus musculus	85-95
9836590-12	1998	It was concluded from these studies that secretin may be stored in a hexameric form within its secretory tissues and that zinc may play a role in the storage of secretin through a specific interaction with the N-terminal histidine and aspartic acid residues.	Histidine	221-230	secretin	Homo sapiens	161-169
9880037-3	1998	This variant contains only three instead of the usual five copies of a short peptide repeat [Pro-Gln/His-Gly-Gly-Gly-(Gly)-TrpGly-Gln] characteristic of PrP, with an additional Trp to Gly substitution in codon 102.	Histidine	101-104	major prion protein	Capra hircus	153-156
9829702-5	1998	These include the conserved Theta class residues Arg 107, Trp 115, and the conserved GSTT1 subclass residue His 176.	Histidine	108-111	glutathione S-transferase theta 1	Homo sapiens	85-90
9831246-8	1998	Amino acid residues Phe-1264 and His-1265 of IR are in a region comparable to Tyr-1250 and Tyr-1251 within human IGF-IR.	Histidine	33-36	insulin like growth factor 1 receptor	Homo sapiens	113-119
9822825-3	1998	Unexpectedly, most other naturally occurring L-amino acids found in proteins (with the exception of proline, lysine, arginine and histidine) have the same effect on the expression of BAP3.	Histidine	130-139	amino acid transporter BAP3	Saccharomyces cerevisiae S288C	183-187
9774399-0	1998	Mutation at histidine 338 of gp91(phox) depletes FAD and affects expression of cytochrome b558 of the human NADPH oxidase.	Histidine	12-21	BRCA2 DNA repair associated	Homo sapiens	49-52
9774399-0	1998	Mutation at histidine 338 of gp91(phox) depletes FAD and affects expression of cytochrome b558 of the human NADPH oxidase.	Histidine	12-21	mitochondrially encoded cytochrome b	Homo sapiens	79-91
9774399-9	1998	These results indicate that His-338 is a very critical residue for FAD incorporation into the NADPH oxidase system.	Histidine	28-31	BRCA2 DNA repair associated	Homo sapiens	67-70
9856476-6	1998	Reverse transcription/polymerase chain reaction and sequence analysis revealed a C to T transition replacing histidine at amino acid position 101 (His101) by tyrosine in gp91-phox.	Histidine	109-118	cytochrome b-245 beta chain	Homo sapiens	170-179
9807817-5	1998	The interaction between AtFKBP12 and AtFIP37 in the 2-hybrid system, as assessed by histidine auxotrophy and beta-galactosidase activity, was disrupted by FK506, but not by cyclosporin A, a drug that binds to cyclophilin A.	Histidine	84-93	FKBP12 interacting protein 37	Arabidopsis thaliana	37-44
9718294-12	1998	Interestingly, lecithin:cholesterol acyltransferase (LCAT) activation results correlate qualitatively with the lipid-binding affinity for all mutants but apo Delta(88-98)A-I(+his), suggesting that this mutant has an altered and possibly noncooperative lipid-bound structure as well as an altered lipid-free structure.	Histidine	175-178	lecithin-cholesterol acyltransferase	Homo sapiens	15-51
9718294-12	1998	Interestingly, lecithin:cholesterol acyltransferase (LCAT) activation results correlate qualitatively with the lipid-binding affinity for all mutants but apo Delta(88-98)A-I(+his), suggesting that this mutant has an altered and possibly noncooperative lipid-bound structure as well as an altered lipid-free structure.	Histidine	175-178	lecithin-cholesterol acyltransferase	Homo sapiens	53-57
9655916-5	1998	When His-58 (non-conserved basic residue with DNA-binding potential in the same helical region) was changed to a Gln, the mutated protein was able to protect the ICR from DNase I digestion.	Histidine	5-8	DNase I	Xenopus laevis	171-178
9723890-4	1998	In contrast to STC-1, the predicted amino acid sequence of STC-2 contains a cluster of histidine residues in the C-terminal portion of the protein, which suggests that STC-2 may interact with metal ions.	Histidine	87-96	stanniocalcin 2	Homo sapiens	59-64
9723890-4	1998	In contrast to STC-1, the predicted amino acid sequence of STC-2 contains a cluster of histidine residues in the C-terminal portion of the protein, which suggests that STC-2 may interact with metal ions.	Histidine	87-96	stanniocalcin 2	Homo sapiens	168-173
9633600-3	1998	The amino acid residues participating in the two transitions were ascribed to His 48 and the N-terminal alpha-amino group for the active enzyme and to His 48 and Arg -1 for the proenzyme.	Histidine	78-81	arginase 1	Bos taurus	162-168
9633600-3	1998	The amino acid residues participating in the two transitions were ascribed to His 48 and the N-terminal alpha-amino group for the active enzyme and to His 48 and Arg -1 for the proenzyme.	Histidine	151-154	arginase 1	Bos taurus	162-168
9622597-4	1998	The protein was purified with its SAT activity, which was inhibited by cysteine, using the high affinity of the histidine tag in an Ni-NTA column.	Histidine	112-121	streptothricin acetyltransferase	Escherichia coli	34-37
9646941-0	1998	Synergistic activation of soluble guanylate cyclase by YC-1 and carbon monoxide: implications for the role of cleavage of the iron-histidine bond during activation by nitric oxide.	Histidine	131-140	RNA binding motif single stranded interacting protein 1	Homo sapiens	55-59
9535834-7	1998	These new findings lead us to conclude that the formation of the alpha1beta1 contact produces in the beta chain a conformational constraint whereby the distal histidine at position 63 is tilted away slightly from the bound dioxygen, preventing the proton-catalyzed displacement of O-2 by a solvent water molecule.	Histidine	159-168	immunoglobulin kappa variable 1D-39	Homo sapiens	281-284
9541544-0	1998	Modeling based on the structure of vicilins predicts a histidine cluster in the active site of oxalate oxidase.	Histidine	55-64	germin-like protein 8-4	Triticum aestivum	95-110
9520398-10	1998	Disruption of histone deacetylase activity either by TPX or by direct mutation of a histidine presumed to be in the active site abrogates HDAC1-mediated transcriptional repression of a targeted reporter gene in vivo.	Histidine	84-93	histone deacetylase 9	Homo sapiens	14-33
9502416-8	1998	Amino-terminal sequence analysis of the protein revealed a Gly-Pro-Ala-Lys-Ser-Pro-Tyr-Gln-Leu-Val-Leu-Gln-His-Ser-Arg sequence indistinguishable from an amino-terminal protein sequence deduced from a cDNA clone designated beta ig-h3, and it as well as the abnormal accumulations in GCD cross-reacted with beta ig-h3 antiserum.	Histidine	107-110	transforming growth factor beta induced	Homo sapiens	223-233
9502416-8	1998	Amino-terminal sequence analysis of the protein revealed a Gly-Pro-Ala-Lys-Ser-Pro-Tyr-Gln-Leu-Val-Leu-Gln-His-Ser-Arg sequence indistinguishable from an amino-terminal protein sequence deduced from a cDNA clone designated beta ig-h3, and it as well as the abnormal accumulations in GCD cross-reacted with beta ig-h3 antiserum.	Histidine	107-110	transforming growth factor beta induced	Homo sapiens	306-316
9525272-0	1998	Induction and localization of cytochrome P450 1B1 (CYP1B1) protein in the livers of TCDD-treated rats: detection using polyclonal antibodies raised to histidine-tagged fusion proteins produced and purified from bacteria.	Histidine	151-160	cytochrome P450, family 1, subfamily b, polypeptide 1	Rattus norvegicus	30-49
9525272-0	1998	Induction and localization of cytochrome P450 1B1 (CYP1B1) protein in the livers of TCDD-treated rats: detection using polyclonal antibodies raised to histidine-tagged fusion proteins produced and purified from bacteria.	Histidine	151-160	cytochrome P450, family 1, subfamily b, polypeptide 1	Rattus norvegicus	51-57
9541395-4	1998	Mutations at any of the four catalytic amino acids His 134, His 252, Glu 78, and Asp 212 drastically reduced the hydrolytic activity of DNase I.	Histidine	51-54	deoxyribonuclease 1	Homo sapiens	136-143
9541395-4	1998	Mutations at any of the four catalytic amino acids His 134, His 252, Glu 78, and Asp 212 drastically reduced the hydrolytic activity of DNase I.	Histidine	60-63	deoxyribonuclease 1	Homo sapiens	136-143
9516042-5	1998	We submit that histidine clusters, residing both in the Alzheimer"s beta-amyloid peptide and in most of the APP/APLP superfamily of proteins, constitute high-affinity binding sites for immobilized metal chelates.	Histidine	15-24	amyloid beta precursor like protein 1	Homo sapiens	112-116
9510129-6	1998	A multiple sequence alignment prepared with five mammalian and five invertebrate peroxidases shows complete conservation of Arg 396, as well as residues corresponding to His 239, His 494, and Asn 579 in TPO.	Histidine	170-173	thyroid peroxidase	Homo sapiens	203-206
9510129-6	1998	A multiple sequence alignment prepared with five mammalian and five invertebrate peroxidases shows complete conservation of Arg 396, as well as residues corresponding to His 239, His 494, and Asn 579 in TPO.	Histidine	179-182	thyroid peroxidase	Homo sapiens	203-206
10726060-8	1998	Another important feature of the NS3 proteinase is the presence of a tetrahedral zinc-binding site formed by residues Cys-97, Cys-99, Cys-145 and His-149.	Histidine	146-149	KRAS proto-oncogene, GTPase	Homo sapiens	33-36
9398308-0	1997	Histidine --&gt; carboxamide ligand substitutions in the zinc binding site of carbonic anhydrase II alter metal coordination geometry but retain catalytic activity.	Histidine	0-9	carbonic anhydrase 2	Homo sapiens	78-99
9398308-1	1997	The catalytic zinc ion of human carbonic anhydrase II (CAII) is coordinated by three histidine ligands (H94, H96, and H119) and a hydroxide ion with tetrahedral geometry.	Histidine	85-94	carbonic anhydrase 2	Homo sapiens	32-53
9398308-1	1997	The catalytic zinc ion of human carbonic anhydrase II (CAII) is coordinated by three histidine ligands (H94, H96, and H119) and a hydroxide ion with tetrahedral geometry.	Histidine	85-94	carbonic anhydrase 2	Homo sapiens	55-59
9354703-0	1997	Functional expression and purification of histidine-tagged rat renal Na/Phosphate (NaPi-2) and Na/Sulfate (NaSi-1) cotransporters.	Histidine	42-51	solute carrier family 13 member 1	Rattus norvegicus	107-113
9353323-5	1997	The Tyr-701 mutant (followed by the His-713 mutant) were most effective in disabling Stat1 function and in overcoming the activating effect of cotransfected wild-type Stat1 in this cell system thereby highlighting the effectiveness of blocking Stat1 homo- and hetero-dimerization.	Histidine	36-39	signal transducer and activator of transcription 1	Homo sapiens	85-90
9353323-5	1997	The Tyr-701 mutant (followed by the His-713 mutant) were most effective in disabling Stat1 function and in overcoming the activating effect of cotransfected wild-type Stat1 in this cell system thereby highlighting the effectiveness of blocking Stat1 homo- and hetero-dimerization.	Histidine	36-39	signal transducer and activator of transcription 1	Homo sapiens	167-172
9353323-5	1997	The Tyr-701 mutant (followed by the His-713 mutant) were most effective in disabling Stat1 function and in overcoming the activating effect of cotransfected wild-type Stat1 in this cell system thereby highlighting the effectiveness of blocking Stat1 homo- and hetero-dimerization.	Histidine	36-39	signal transducer and activator of transcription 1	Homo sapiens	167-172
9353323-7	1997	Then by transfecting hTBECs with wild-type or mutant Stat1 tagged with a Flag reporter sequence, we used dual immunofluorescence to show that hTBECs expressing the Tyr-701 or His-713 mutants were prevented from expressing endogenous ICAM-1 in response to IFN-gamma treatment.	Histidine	175-178	signal transducer and activator of transcription 1	Homo sapiens	53-58
20654366-4	1997	Amino acid analysis of the hydrolysed (HC1) protein showed that His and Tyr undergo a dramatic decrease (approx.	Histidine	64-67	CYCS pseudogene 39	Homo sapiens	39-42
9306693-3	1997	The HSF1 kinase forms a stable complex with AtHSF1, which can be detected by kinase pull-down assays using a histidine-tagged AtHSF1 substrate.	Histidine	109-118	heat shock factor 1	Arabidopsis thaliana	4-8
9218440-6	1997	Our previous studies have identified a mutation at position 332 within Drosophila TBP that changes a highly conserved arginine residue to a histidine residue, which renders it specifically defective in its ability to support RNA polymerase III transcription in S-2 cells (Trivedi, A., Vilalta, A., Gopalan, S., and Johnson, D. L. (1996) Mol.	Histidine	140-149	df	Drosophila melanogaster	189-198
9211916-9	1997	CobT phosphoribosylated alternative base substrates including benzimidazole, 4,5-dimethyl-1,2-phenylenediamine, imidazole, histidine, adenine, and guanine in vitro.	Histidine	123-132	nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Salmonella enterica subsp. enterica serovar Typhimurium str. LT2	0-4
9148914-5	1997	A detailed kinetic analysis of AAP5 using lysine, alanine, glutamate, and histidine revealed H+-dependent differences in the apparent affinity constants for each substrate.	Histidine	74-83	amino acid permease 5	Arabidopsis thaliana	31-35
9148914-6	1997	The differences were correlated to the effect of H+ concentration on the net charge of each amino acid and suggested that AAP5 transports only the neutral species of histidine and glutamate.	Histidine	166-175	amino acid permease 5	Arabidopsis thaliana	122-126
9215578-3	1997	Cloning and expression of the TIMP-3 were performed in Escherichia coli as a fusion protein with a 36 amino acid N-tail containing a His cluster.	Histidine	133-136	TIMP metallopeptidase inhibitor 3	Homo sapiens	30-36
9092499-5	1997	The isolated GFRP cDNA was expressed in Escherichia coli as a fusion protein with six consecutive histidine residues at its N terminus.	Histidine	98-107	GTP cyclohydrolase I feedback regulator	Rattus norvegicus	13-17
9108299-7	1997	In contrast to cathepsins L, S, K, B, H and O, cathepsin W contains a 21-amino acid peptide insertion between the putative active site histidine and asparagine residues and an 8-amino acid C-terminal extension.	Histidine	135-144	cathepsin W	Homo sapiens	47-58
9045649-4	1997	Functional recombinant RF-C containing p40-his, p37-his, or p36-his was isolated using affinity resin.	Histidine	43-46	replication factor C subunit 1	Homo sapiens	23-27
9045649-4	1997	Functional recombinant RF-C containing p40-his, p37-his, or p36-his was isolated using affinity resin.	Histidine	52-55	replication factor C subunit 1	Homo sapiens	23-27
9045649-4	1997	Functional recombinant RF-C containing p40-his, p37-his, or p36-his was isolated using affinity resin.	Histidine	52-55	replication factor C subunit 1	Homo sapiens	23-27
9147644-1	1997	We have generated polyclonal antibodies against the amino-terminal third of the Menkes protein (ATP7A; MNK) by immunizing rabbits with a histidine-tagged MNK fusion construct containing metal-binding domains 1-4.	Histidine	137-146	ATPase copper transporting alpha	Homo sapiens	103-106
9147644-1	1997	We have generated polyclonal antibodies against the amino-terminal third of the Menkes protein (ATP7A; MNK) by immunizing rabbits with a histidine-tagged MNK fusion construct containing metal-binding domains 1-4.	Histidine	137-146	ATPase copper transporting alpha	Homo sapiens	154-157
9238644-3	1997	The histidine-epsilon-amino caproic acid-beta-alanine-histidine (His-epsilon Ahx-beta Ala-His) sequence was found to yield optimal inhibition of both MMP-2 and MMP-9.	Histidine	65-68	matrix metallopeptidase 9	Homo sapiens	160-165
9016654-3	1996	TIF1 beta, TIF1 alpha, PML and efp belong to a characteristic subgroup of RING finger proteins that contain one or two other Cys/His-rich clusters (B boxes) and a putative coiled-coil in addition to the classical C3HC4 RING finger motif (RBCC configuration).	Histidine	129-132	tripartite motif containing 24	Homo sapiens	11-21
8980679-1	1996	A recA mutant (recA423; Arg169--&gt;His), with properties that should help clarify the relationship between the biochemical properties of RecA protein and its two major functions, homologous genetic recombination and recombinational DNA repair, has been isolated.	Histidine	36-39	RAD51 recombinase	Homo sapiens	2-6
8980679-1	1996	A recA mutant (recA423; Arg169--&gt;His), with properties that should help clarify the relationship between the biochemical properties of RecA protein and its two major functions, homologous genetic recombination and recombinational DNA repair, has been isolated.	Histidine	36-39	RAD51 recombinase	Homo sapiens	138-142
8798701-1	1996	The role of the four histidine residues in receptor binding and activity of mouse nerve growth factor (NGF) was investigated using both site-directed mutagenesis and chemical modification with diethyl pyrocarbonate.	Histidine	21-30	nerve growth factor	Mus musculus	82-101
8798701-1	1996	The role of the four histidine residues in receptor binding and activity of mouse nerve growth factor (NGF) was investigated using both site-directed mutagenesis and chemical modification with diethyl pyrocarbonate.	Histidine	21-30	nerve growth factor	Mus musculus	103-106
8883261-0	1996	A mutant (Arg327--&gt;His) GPIIb associated to thrombasthenia exerts a dominant negative effect in stably transfected CHO cells.	Histidine	22-25	integrin subunit alpha 2b	Homo sapiens	27-32
8753810-4	1996	Substitution of Cys-16, Cys-31, or His-33 markedly decreased the transforming activity of Rfp/Ret.	Histidine	35-38	tripartite motif-containing 27	Mus musculus	90-93
8753810-6	1996	In contrast, mutations of Cys-118 or His-124 in the second cysteine/histidine-rich motif (called B box) of Rfp/Ret did not affect its activity.	Histidine	37-40	tripartite motif-containing 27	Mus musculus	107-110
8753810-6	1996	In contrast, mutations of Cys-118 or His-124 in the second cysteine/histidine-rich motif (called B box) of Rfp/Ret did not affect its activity.	Histidine	68-77	tripartite motif-containing 27	Mus musculus	107-110
8807898-1	1996	BACKGROUND: The Zn(II)-binding site from the active center of human carbonic anhydrase II, formed by three His side chains, can be grafted onto the recombinant serum retinol-binding protein (RBP).	Histidine	107-110	carbonic anhydrase 2	Homo sapiens	68-89
8807898-1	1996	BACKGROUND: The Zn(II)-binding site from the active center of human carbonic anhydrase II, formed by three His side chains, can be grafted onto the recombinant serum retinol-binding protein (RBP).	Histidine	107-110	retinol binding protein 4	Homo sapiens	166-189
8807898-1	1996	BACKGROUND: The Zn(II)-binding site from the active center of human carbonic anhydrase II, formed by three His side chains, can be grafted onto the recombinant serum retinol-binding protein (RBP).	Histidine	107-110	retinol binding protein 4	Homo sapiens	191-194
8827453-0	1996	Effects of substitutions of the conserved histidine residues in human gamma-glutamyl transpeptidase.	Histidine	42-51	inactive glutathione hydrolase 2	Homo sapiens	70-99
8827453-1	1996	gamma-Glutamyl transpeptidase possesses two histidine residues at positions 383 and 505 which are conserved in all mammalian and bacterial species.	Histidine	44-53	inactive glutathione hydrolase 2	Homo sapiens	0-29
8605175-0	1996	The designed protein M(II)-Gly-Lys-His-Fos(138-211) specifically cleaves the AP-1 binding site containing DNA.	Histidine	35-38	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	39-42
8605175-1	1996	A new specific DNA cleavage protein, Gly-Lys-His-Fos(138-211), was designed, expressed, and characterized.	Histidine	45-48	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	49-52
8639494-0	1996	Reversal of the hydrogen bond to zinc ligand histidine-119 dramatically diminishes catalysis and enhances metal equilibration kinetics in carbonic anhydrase II.	Histidine	45-54	carbonic anhydrase 2	Homo sapiens	138-159
8639500-4	1996	In the present investigation, we explore the role of all remaining charged residues by producing and characterizing mutants of ApB at Asp-7, Asp-9, Lys-37, His-39, and His-34.	Histidine	156-159	arginyl aminopeptidase	Homo sapiens	127-130
8639500-4	1996	In the present investigation, we explore the role of all remaining charged residues by producing and characterizing mutants of ApB at Asp-7, Asp-9, Lys-37, His-39, and His-34.	Histidine	168-171	arginyl aminopeptidase	Homo sapiens	127-130
8621424-5	1996	Here we show that the binding site of NT-3 to its non-preferred receptors TrkA and TrkB is dominated by two positively charged residues, Arg-31 and His-33, previously shown to constitute a main determinant of binding to p75LNGFR.	Histidine	148-151	neurotrophin 3	Homo sapiens	38-42
8652624-0	1996	Proton NMR study of peptides from myelin basic protein: evidence for Lys74-His77 interaction revealed from histidine line broadening.	Histidine	107-116	myelin basic protein	Rattus norvegicus	34-54
8652624-3	1996	Synthetic peptides analogous to this region of MBP containing glycine and histidine are encephalitogenic if they lack the N-terminal half, residues 69-74.	Histidine	74-83	myelin basic protein	Rattus norvegicus	47-50
8652624-5	1996	This was investigated by measuring the 1H-NMR spectra of synthetic peptides analogous to this region of MBP, both containing histidine but with and without the N-terminal half.	Histidine	125-134	myelin basic protein	Rattus norvegicus	104-107
8785285-1	1996	We have previously proposed that acidification-induced regulation of the cardiac gap junction protein connexin43 (Cx43) may be modeled as a particle-receptor interaction between two separate domains of Cx43: the carboxyl terminal (acting as a particle), and a region including histidine 95 (acting as a receptor).	Histidine	277-286	gap junction protein alpha 1 S homeolog	Xenopus laevis	102-112
8785285-1	1996	We have previously proposed that acidification-induced regulation of the cardiac gap junction protein connexin43 (Cx43) may be modeled as a particle-receptor interaction between two separate domains of Cx43: the carboxyl terminal (acting as a particle), and a region including histidine 95 (acting as a receptor).	Histidine	277-286	gap junction protein alpha 1 S homeolog	Xenopus laevis	114-118
8785285-1	1996	We have previously proposed that acidification-induced regulation of the cardiac gap junction protein connexin43 (Cx43) may be modeled as a particle-receptor interaction between two separate domains of Cx43: the carboxyl terminal (acting as a particle), and a region including histidine 95 (acting as a receptor).	Histidine	277-286	gap junction protein alpha 1 S homeolog	Xenopus laevis	202-206
8920637-2	1996	The aim of the present study was to define the time course of changes in peptide-chain initiation, albumin synthesis, and albumin mRNA following histidine deprivation and the reversal of these changes in response to readdition of the deprived amino acid.	Histidine	145-154	albumin	Rattus norvegicus	122-129
8814878-5	1996	Importantly, the effective substitution of the oxazole O-1 for the histidine N-1 further illustrates that this group does not require deprotonation upon metal complexation, oxygen activation, or the ensuing oxidation reactions, that the functional bleomycin A2 tautomer is the imidazole N"-H tautomer, and that the imidazole N"-H functionality is not contributing to the polynucleotide recognition through H-bonding to the phosphate backbone or nucleotide bases.	Histidine	67-76	immunoglobulin kappa variable 2D-40	Homo sapiens	55-58
8573077-8	1996	Our results are consistent with Zn2+ chelation by the highly conserved histidine residues homologous to the histidines at the classical copper-binding sites in tyrosinase.	Histidine	71-80	tyrosinase	Homo sapiens	160-170
8573077-8	1996	Our results are consistent with Zn2+ chelation by the highly conserved histidine residues homologous to the histidines at the classical copper-binding sites in tyrosinase.	Histidine	108-118	tyrosinase	Homo sapiens	160-170
8631326-6	1996	Protein mass fingerprinting with tryptic fragments identified p57 as a protein related to protein disulfide-isomerase which belongs to the superfamily of Cys-Gly-His-Cys-containing sequences.	Histidine	162-165	prolyl 4-hydroxylase subunit beta	Rattus norvegicus	90-117
8825190-1	1996	The pharmacokinetics of L-histidine in humans has been investigated to evaluate the in vivo histidine ammonia lyase system for the conversion of L-histidine to urocanic acid.	Histidine	145-156	histidine ammonia-lyase	Homo sapiens	92-115
8523543-3	1996	Altered ATRC1 receptors bearing either a phenylalanine, a tryptophan, a histidine, or a methionine at position 235 mediated ecotropic virus entry comparable to that mediated by ATRC1.	Histidine	72-81	solute carrier family 7 member 1	Homo sapiens	8-13
8530633-2	1995	Affected individuals have a single base substitution in exon 8 of CYP11B1 gene, codon 448, from CGC (arginine) to CAC (histidine) (R448H), a mutation that abolishes enzyme activity completely.	Histidine	119-128	cytochrome P450 family 11 subfamily B member 1	Homo sapiens	66-73
7489704-3	1995	The amino-terminal domain binds in a substrate-like manner to the narrow active-site cleft of thrombin; the imidazole group of the P1 His residue extends into the S1 pocket to form favourable hydrogen/ionic bonds with Asp189 at its bottom, and additionally with Glu192 at its entrance.	Histidine	134-137	coagulation factor II, thrombin	Bos taurus	94-102
7479069-9	1995	Mutations at three sites, histidine 126, aspartic acid 128 and aspartic acid 130, that are conserved in a subfamily of the plasmid mobilization proteins, led to the loss of VirD2 activity.	Histidine	26-35	type IV secretion system T-DNA border endonuclease VirD2	Agrobacterium tumefaciens	173-178
7592604-2	1995	Chemical modification data implicate histidine as a catalytic residue of PBGS from both plants and mammals.	Histidine	37-46	aminolevulinate dehydratase	Homo sapiens	73-77
7592604-4	1995	Only one histidine is species-invariant among 17 known sequences of PBGS which have high overall sequence similarity.	Histidine	9-18	aminolevulinate dehydratase	Homo sapiens	68-72
7592604-5	1995	In Escherichia coli PBGS, this histidine is His128.	Histidine	31-40	aminolevulinate dehydratase	Homo sapiens	20-24
7592604-15	1995	We observe a pKa of approximately 7.5 in the wild type PBGS kcat/Km pH profile as well as in those of H128A and H126/128A, suggesting that this pKa is not the result of protonation/deprotonation of one of these histidines.	Histidine	211-221	aminolevulinate dehydratase	Homo sapiens	55-59
7592604-17	1995	This is consistent with a role for one or both of these histidines as a ligand to the required Zn(II) of E. coli PBGS, which is known to participate in substrate binding.	Histidine	56-66	aminolevulinate dehydratase	Homo sapiens	113-117
7548163-2	1995	The PI-6 cDNA was modified to encode six histidine residues immediately after the initiation codon, and was placed under the control of the P. pastoris alcohol oxidase promoter in the vector pHIL-D2.	Histidine	41-50	serpin family B member 6	Homo sapiens	4-8
7677750-4	1995	Substitution of His-117 with polar, charged, or hydrophobic amino acid resulted in complete abolishment of the tyrosinase activity but no effect on its secretion.	Histidine	16-19	tyrosinase	Homo sapiens	111-121
7677750-5	1995	When similar amino acid substitutions were introduced at His-102, both the secretion and the enzymatic activity of tyrosinase were blocked to different extents.	Histidine	57-60	tyrosinase	Homo sapiens	115-125
7677750-6	1995	Furthermore, the tyrosinase activity of the His-117 mutants but not the His-102 mutants could be partially reactivated by in vitro copper reconstitution.	Histidine	44-47	tyrosinase	Homo sapiens	17-27
8530107-1	1995	Histidase (EC 4.3.1.3) is a cytosolic enzyme that catalyzes the nonoxidative deamination of histidine to urocanic acid.	Histidine	92-101	histidine ammonia-lyase	Homo sapiens	0-9
7656990-2	1995	Among them, NTR1 codes for a membrane protein with weak histidine transport activity.	Histidine	56-65	peptide transporter 2	Arabidopsis thaliana	12-16
7643379-1	1995	The two zinc fingers of the yeast transcription factor Adr1p recognize the 6 bp sequence TTG GAG site in which the first finger, a His-X3-His finger, recognizes the G-rich triplet (GAG) and the second zinc finger, a His-X4-His finger, recognizes the T-rich sequence (TTG).	Histidine	131-134	DNA-binding transcription factor ADR1	Saccharomyces cerevisiae S288C	55-60
7643379-1	1995	The two zinc fingers of the yeast transcription factor Adr1p recognize the 6 bp sequence TTG GAG site in which the first finger, a His-X3-His finger, recognizes the G-rich triplet (GAG) and the second zinc finger, a His-X4-His finger, recognizes the T-rich sequence (TTG).	Histidine	138-141	DNA-binding transcription factor ADR1	Saccharomyces cerevisiae S288C	55-60
7643379-1	1995	The two zinc fingers of the yeast transcription factor Adr1p recognize the 6 bp sequence TTG GAG site in which the first finger, a His-X3-His finger, recognizes the G-rich triplet (GAG) and the second zinc finger, a His-X4-His finger, recognizes the T-rich sequence (TTG).	Histidine	138-141	DNA-binding transcription factor ADR1	Saccharomyces cerevisiae S288C	55-60
7643379-1	1995	The two zinc fingers of the yeast transcription factor Adr1p recognize the 6 bp sequence TTG GAG site in which the first finger, a His-X3-His finger, recognizes the G-rich triplet (GAG) and the second zinc finger, a His-X4-His finger, recognizes the T-rich sequence (TTG).	Histidine	138-141	DNA-binding transcription factor ADR1	Saccharomyces cerevisiae S288C	55-60
7623840-2	1995	Previous studies have shown that in response to histidine starvation, GCN2 phosphorylates eukaryotic initiation factor 2 (eIF-2), to induce the translational expression of GCN4, a transcriptional activator of genes subject to the general amino acid control.	Histidine	48-57	eukaryotic translation initiation factor 2 alpha kinase 4	Homo sapiens	70-74
7623840-6	1995	We show that GCN2 phosphorylation of eIF-2, and the resulting general amino acid control pathway, is stimulated in response to starvation for each of several different amino acids, in addition to histidine limitation.	Histidine	196-205	eukaryotic translation initiation factor 2 alpha kinase 4	Homo sapiens	13-17
7637580-0	1995	Molecular cloning of cDNA encoding a bovine selenoprotein P-like protein containing 12 selenocysteines and a (His-Pro) rich domain insertion, and its regional expression.	Histidine	110-113	selenoprotein P	Bos taurus	44-72
7782943-4	1995	We have developed an efficient histidine-tagged bacterial expression system that allows the folding and assembly of E1 alpha and E1 beta subunits into the E1 heterotetramer (alpha 2 beta 2) in the presence of overexpressed chaperonins GroEL and GroES.	Histidine	31-40	heat shock protein family D (Hsp60) member 1	Homo sapiens	235-240
7781967-2	1995	The primary structure of VIP from both species was the same: His-Ser-Asp-Ala-Ile-Phe-Thr-Asp-Asn-Tyr10- Ser-Arg-Phe-Arg-Lys-Gln-Met-Ala-Val-Lys20-Lys-Tyr-Leu-Asn-Ser-Val- Leu-Thr.	Histidine	61-64	vasoactive intestinal peptide	Gallus gallus	25-28
7893699-7	1995	EPR and EXAFS studies of oxidized PHM indicate that the active site contains type 2 copper in a tetragonal environment; the copper is coordinated to two to three His and one to two additional O/N ligands, probably solvent, again supporting the structural homology of PHM and D beta M. Mutation of the Met residues common to PHM and D beta M to Ile identified Met314 as critical for catalytic activity.	Histidine	162-165	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	34-37
7873529-7	1995	Conversely, modification of arginine or histidine residues of HPRG has no effect on complex formation.	Histidine	40-49	histidine rich glycoprotein	Homo sapiens	62-66
7849014-0	1995	Site-directed mutagenesis of conserved histidines in the helix VIII domain of PsaB impairs assembly of the photosystem I reaction center without altering spectroscopic characteristics of P700.	Histidine	39-49	photosystem I P700 chlorophyll a apoprotein A2	Chlamydomonas reinhardtii	78-82
7849014-2	1995	Histidine residues in the most highly conserved region of the PsaB protein are predicted to coordinate the P700 reaction center chlorophyll(s) and the initial electron acceptor, A0.	Histidine	0-9	photosystem I P700 chlorophyll a apoprotein A2	Chlamydomonas reinhardtii	62-66
7803386-3	1994	The structure of H94C CAII reveals the successful substitution of the naturally occurring histidine zinc ligand by a cysteine thiolate, and metal coordination by C94 is facilitated by the plastic structural response of the beta-sheet superstructure.	Histidine	90-99	carbonic anhydrase 2	Homo sapiens	22-26
7838710-6	1994	The results of the experiments using bacterially expressed MSSP-2, and its deletion mutants, as histidine fusion proteins suggested that the binding specificity of MSSP-2 to double- and single-stranded DNA is the same as that of MSSP-1, and that the RNP consensus sequences are required for the DNA binding of the protein.	Histidine	96-105	RNA binding motif single stranded interacting protein 1	Homo sapiens	164-170
7947824-3	1994	One mutant, RBP/H3(A), with His residues introduced at the positions 46, 54, and 56 in the polypeptide sequence was shown to bind Zn(II) specifically with a stoichiometry of 1 and a corresponding dissociation constant equal to 36 +/- 10 nM.	Histidine	28-31	retinol binding protein 4	Homo sapiens	12-15
7980562-0	1994	Peptides corresponding to the region adjacent to His-94 in the small subunit of cytochrome b558 inhibit superoxide generation in a cell-free system from human neutrophils.	Histidine	49-52	mitochondrially encoded cytochrome b	Homo sapiens	80-92
7980562-1	1994	Synthetic peptides corresponding to the region adjacent to His-94 in the small subunit of cytochrome b558 inhibited superoxide generation in a cell-free system.	Histidine	59-62	mitochondrially encoded cytochrome b	Homo sapiens	90-102
7925571-7	1994	The pH dependence of IgG1 or Fc fragment binding to FcRn is consistent with the localization of the FcRn interaction site to a region of the Fc that encompasses two histidine residues (His 310 and His 433).	Histidine	165-174	LOC105243590	Mus musculus	21-25
7925571-7	1994	The pH dependence of IgG1 or Fc fragment binding to FcRn is consistent with the localization of the FcRn interaction site to a region of the Fc that encompasses two histidine residues (His 310 and His 433).	Histidine	185-188	LOC105243590	Mus musculus	21-25
7925571-7	1994	The pH dependence of IgG1 or Fc fragment binding to FcRn is consistent with the localization of the FcRn interaction site to a region of the Fc that encompasses two histidine residues (His 310 and His 433).	Histidine	197-200	LOC105243590	Mus musculus	21-25
8093013-6	1994	Moreover, modification of the second histidine is prevented by the presence of Ca(II).	Histidine	37-46	carbonic anhydrase 2	Homo sapiens	79-85
8093013-7	1994	These results indicate that the second histidine is serving as a ligand for Ca(II) and the bound Ca(II) is directly involved in enzyme catalysis.	Histidine	39-48	carbonic anhydrase 2	Homo sapiens	76-82
8093013-7	1994	These results indicate that the second histidine is serving as a ligand for Ca(II) and the bound Ca(II) is directly involved in enzyme catalysis.	Histidine	39-48	carbonic anhydrase 2	Homo sapiens	97-103
8035800-4	1994	The iap genes encode a C3HC4 (or RING) finger motif found in a number of transcriptional regulatory proteins, as well as two additional Cys/His motifs (baculovirus iap repeats).	Histidine	140-143	magnesium transporter 1	Homo sapiens	4-7
8034673-7	1994	Expression and analysis of site-directed mutants of CPT II showed that histidine 372, as well as aspartates 376 and 464 (all conserved throughout the carnitine/choline acyltransferase family), are essential for catalytic activity.	Histidine	71-80	carnitine palmitoyltransferase 2	Rattus norvegicus	52-58
8034673-8	1994	The data suggest that the mechanism by which CPT II effects transesterification between palmitoyl-CoA and carnitine possibly involves histidine 372 and one of these aspartate residues, interacting with the carnitine hydroxyl group, in a reaction analogous to that carried out by a histidine/aspartate/serine catalytic triad in certain other enzyme systems.	Histidine	134-143	carnitine palmitoyltransferase 2	Rattus norvegicus	45-51
8034673-8	1994	The data suggest that the mechanism by which CPT II effects transesterification between palmitoyl-CoA and carnitine possibly involves histidine 372 and one of these aspartate residues, interacting with the carnitine hydroxyl group, in a reaction analogous to that carried out by a histidine/aspartate/serine catalytic triad in certain other enzyme systems.	Histidine	281-290	carnitine palmitoyltransferase 2	Rattus norvegicus	45-51
7913462-4	1994	rITF2 is a rat homolog of human ITF2 (or E2-2), and CDP2 is a member of a new family of homeoproteins defined by histidine as the 9th residue of the recognition helix and by unique 64 amino acid repeats related to those of the Drosophila cut gene.	Histidine	113-122	cut like homeobox 2	Homo sapiens	52-56
8027057-1	1994	The catalysis of the hydration of CO2 by human carbonic anhydrase II (HCA II) includes the transfer of a proton from zinc-bound water to histidine 64 utilizing a network of intervening hydrogen-bonded water molecules, then the proton is transferred to buffer in solution.	Histidine	137-146	carbonic anhydrase 2	Homo sapiens	47-68
8010958-0	1994	The effect of replacing the conserved active-site residues His-264, Asp-312 and Arg-314 on the binding and catalytic properties of Escherichia coli citrate synthase.	Histidine	59-62	citrate synthase	Sus scrofa	148-164
8010958-2	1994	Active-site residues Arg-314, Asp-312 and His-264 in Escherichia coli citrate synthase, which are involved in oxaloacetate binding, were converted by site-directed mutagenesis to Gln-314, Asn-312 and Asn-264 respectively.	Histidine	42-45	citrate synthase	Sus scrofa	70-86
8203892-1	1994	Histidine at position 51 of the class I beta 1 alcohol dehydrogenase (ADH) functions as a general base by indirectly abstracting a proton from the alcohol substrate through a hydrogen-bonded proton relay system.	Histidine	0-9	aldo-keto reductase family 1 member A1	Homo sapiens	47-68
8203892-1	1994	Histidine at position 51 of the class I beta 1 alcohol dehydrogenase (ADH) functions as a general base by indirectly abstracting a proton from the alcohol substrate through a hydrogen-bonded proton relay system.	Histidine	0-9	aldo-keto reductase family 1 member A1	Homo sapiens	70-73
8203892-4	1994	Accordingly, we expressed and purified recombinant mutants of pi-ADH with Thr, Ser, and His at position 51.	Histidine	88-91	aldo-keto reductase family 1 member A1	Homo sapiens	65-68
8144590-6	1994	The overall structure of cholinesterases was conserved in ACE-1 as indicated by the conserved sequence positions of Ser-216, His-468, and Glu-346 (S200, H440, E327 in Torpedo (AChE) as components of the catalytic triad, of the six cysteines which form three intrachain disulfide bonds, and of Trp-99(84), a critical side chain in the choline binding site.	Histidine	125-128	ACE1	Drosophila melanogaster	58-63
8253208-0	1993	Characterisation of a novel cysteine/histidine-rich metal binding domain from Xenopus nuclear factor XNF7.	Histidine	37-46	Nuclear factor 7 L homeolog	Xenopus laevis	101-105
8133211-13	1993	Thrombin resistance resulting from substitution of histidine at position 127 of rbGH did not affect blood GH pharmacokinetic parameters or milk response over other rbGH variants.	Histidine	51-60	coagulation factor II, thrombin	Bos taurus	0-8
8281191-4	1993	Thus, AAP2 is less selective as compared with AAP1 and transports basic amino acids such as histidine as shown by expression in a histidine transport-deficient yeast strain.	Histidine	92-101	amino acid permease 2	Arabidopsis thaliana	6-10
8281191-4	1993	Thus, AAP2 is less selective as compared with AAP1 and transports basic amino acids such as histidine as shown by expression in a histidine transport-deficient yeast strain.	Histidine	130-139	amino acid permease 2	Arabidopsis thaliana	6-10
8223609-0	1993	Accessibility to modification of histidine residues of RecA protein upon DNA and cofactor binding.	Histidine	33-42	RAD51 recombinase	Homo sapiens	55-59
8223609-1	1993	The potential role of histidine residues of RecA protein in binding DNA has been investigated by monitoring their accessibility to diethylpyrocarbonate.	Histidine	22-31	RAD51 recombinase	Homo sapiens	44-48
8223609-3	1993	However, both histidine residues become accessible after addition of cofactor analog adenosine 5"-O-(3-thiotriphosphate) (ATP[S]) indicating a change in the organization of the RecA filament and/or a change in the conformation of protein.	Histidine	14-23	RAD51 recombinase	Homo sapiens	177-181
8223609-8	1993	A protection of the histidine residues is also effected by high salt concentration which promotes, just as DNA binding, ATPase and coprotease activity in RecA.	Histidine	20-29	RAD51 recombinase	Homo sapiens	154-158
8223609-9	1993	The protection of histidine residues to diethylpyrocarbonate upon DNA binding probably relates to a conformational change of RecA and may not be any direct effect of shielding by the DNA.	Histidine	18-27	RAD51 recombinase	Homo sapiens	125-129
7687248-8	1993	Sequence analysis of the cloned histidine region, which revealed 98.6% overall homology with that of the previously analyzed prototrophic strain, showed the presence of frameshift mutations in three his genes, hisC, hisG, and hisH, and two genes unrelated to histidine biosynthesis, ORF3 and ORF6.	Histidine	32-41	orf3	Lactococcus lactis	283-287
8212073-4	1993	This mutation is located within exon 2 and alters the codon (CTC) normally associated with Leu-93 in the transcortin polypeptide to a codon (CAC) for histidine in the variant genes.	Histidine	150-159	carbonic anhydrase 2	Homo sapiens	141-144
8484779-2	1993	We expressed mouse CSF-1 in bacteria as a fusion protein either with glutathione S-transferase (GST) or with a six histidine tag (His-tag).	Histidine	115-124	colony stimulating factor 1 (macrophage)	Mus musculus	19-24
8484779-2	1993	We expressed mouse CSF-1 in bacteria as a fusion protein either with glutathione S-transferase (GST) or with a six histidine tag (His-tag).	Histidine	130-133	colony stimulating factor 1 (macrophage)	Mus musculus	19-24
8459399-4	1993	It is proposed that this selectivity reflects interactions with histidine residues on a loop located in the primed subsites of cathepsin B which provides a positively charged anchor for the C-terminal carboxylate group of the inhibitor.	Histidine	64-73	cathepsin B	Homo sapiens	127-138
8449909-10	1993	These experiments confirm that in the active enzyme Zn2+ plays a critical role in catalysis, that a histidine or glutamate residue plays a mechanistic role in the hydrolytic deamination step, and that cysteine is not involved in the catalytic mechanism of adenosine deaminase.	Histidine	100-109	adenosine deaminase	Homo sapiens	256-275
8428624-7	1993	Substitution of Cys-397 of MAO-B, i.e. the residue covalently anchoring FAD, with an Ala or a His residue resulted in the total loss of enzymatic activity, suggesting that the covalent coupling of FAD to MAO occurs specifically at the-SH group of cysteine.	Histidine	94-97	monoamine oxidase B	Homo sapiens	27-32
8364225-1	1993	The oncogene GLI is amplified and expressed in some cases of human malignant glioma and undifferentiated childhood sarcoma and is the prototype for a gene family characterized by a highly conserved set of five tandem zinc fingers and a consensus cysteine-histidine link.	Histidine	255-264	GLI family zinc finger 1	Homo sapiens	4-16
7510795-4	1993	On increasing the pH from 4.5 to 9.5 (at 25.0 degrees C), the affinity of BPTI, as well as bovine and porcine PSTI for cathepsin G increases thus reflecting the acidic-pK shift of the His-57 catalytic residue from approximately 6.9 in the free enzyme to approximately 5.0 in the serine proteinase:inhibitor complexes.	Histidine	184-187	spleen trypsin inhibitor I	Bos taurus	74-78
7510795-4	1993	On increasing the pH from 4.5 to 9.5 (at 25.0 degrees C), the affinity of BPTI, as well as bovine and porcine PSTI for cathepsin G increases thus reflecting the acidic-pK shift of the His-57 catalytic residue from approximately 6.9 in the free enzyme to approximately 5.0 in the serine proteinase:inhibitor complexes.	Histidine	184-187	cathepsin G	Bos taurus	119-130
1332958-2	1992	Thyrotropin-releasing hormone, TRH (&lt; Glu-His-Proamide), and [N tau-Me-His]TRH (MeTRH) are present as neutral and positively charged forms at physiologic pH, and it was possible that they bind to the TRH receptor (TRH-R) as charged (protonated) species.	Histidine	45-48	thyrotropin releasing hormone	Mus musculus	31-34
1332958-2	1992	Thyrotropin-releasing hormone, TRH (&lt; Glu-His-Proamide), and [N tau-Me-His]TRH (MeTRH) are present as neutral and positively charged forms at physiologic pH, and it was possible that they bind to the TRH receptor (TRH-R) as charged (protonated) species.	Histidine	74-77	thyrotropin releasing hormone	Mus musculus	78-81
1332761-10	1992	The excellent agreement between model compounds and isolated Cyt b559 reinforces the validity of the model of a heme iron coordinated to two histidine residues for Cyt b559.	Histidine	141-150	mitochondrially encoded cytochrome b	Homo sapiens	61-66
1378869-8	1992	KE36-7 bound strongly to the 10-mer peptide-gp46 187-196, and weakly to peptides containing the gp46 amino acid sequence 191-196 (Leu-Pro-His-Ser-Asn-Leu).	Histidine	138-141	serpin family H member 1	Homo sapiens	96-100
1630899-2	1992	Based on analogies with metalloenzymes, it is hypothesized that the two conserved His residues in this motif may be involved in metal ion coordination required for the activity of the Rep and Mob proteins.	Histidine	82-85	sphingomyelin synthase 1	Homo sapiens	192-195
1627604-4	1992	The intramolecular binding reaction of the N epsilon of the distal histidine E7 which is observed in methemoglobin in solution cannot be detected in single crystals.	Histidine	67-76	hemoglobin subunit gamma 2	Homo sapiens	101-114
1577733-2	1992	These studies establish that the proton resonances of His(B5) and His(B10) are useful signatures of aggregation and conformation.	Histidine	54-57	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	70-73
1577733-2	1992	These studies establish that the proton resonances of His(B5) and His(B10) are useful signatures of aggregation and conformation.	Histidine	66-69	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	70-73
1349545-3	1992	The deduced amino acid sequence of ap predicts a homeo domain and a cysteine/histidine-rich domain known as the LIM domain.	Histidine	77-86	apterous	Drosophila melanogaster	35-37
1349545-3	1992	The deduced amino acid sequence of ap predicts a homeo domain and a cysteine/histidine-rich domain known as the LIM domain.	Histidine	77-86	LIM homeobox 1	Drosophila melanogaster	112-115
1547771-1	1992	Human serum response factor (SRF) bearing a histidine tag was expressed using vaccinia virus.	Histidine	44-53	serum response factor	Homo sapiens	6-27
1547771-1	1992	Human serum response factor (SRF) bearing a histidine tag was expressed using vaccinia virus.	Histidine	44-53	serum response factor	Homo sapiens	29-32
1371749-13	1992	Since catalysis of ATP-citrate lyase is postulated to involve the formation of phosphohistidine, these results are consistent with the pattern of earlier observations of the significance of the histidine residue in catalysis of the human ATP-citrate lyase.	Histidine	86-95	ATP citrate lyase	Homo sapiens	19-36
1371749-13	1992	Since catalysis of ATP-citrate lyase is postulated to involve the formation of phosphohistidine, these results are consistent with the pattern of earlier observations of the significance of the histidine residue in catalysis of the human ATP-citrate lyase.	Histidine	86-95	ATP citrate lyase	Homo sapiens	238-255
1537807-8	1992	The cloned DNA restored the ability of a histidase structural gene mutant to grow on L-histidine as the sole nitrogen source.	Histidine	85-96	histidine ammonia-lyase	Homo sapiens	41-50
1545235-2	1992	The deduced protein is structurally similar to the yeast KEX2 prohormone endoprotease including the conserved Asp, His, and Ser catalytic triad residues characteristic of the subtilisin family.	Histidine	115-118	kexin KEX2	Saccharomyces cerevisiae S288C	57-61
1370297-2	1992	The ovarian autoimmune disease is induced in B6AF1 mice by a 15-amino acid peptide (Cys-Ser-Asn-Ser-Ser-Ser-Ser-Gln-Phe-Gln-Ile-His-Gly-Pro-Arg) from mouse ZP3, the sperm-binding component of the zona pellucida that surrounds growing and mature oocytes.	Histidine	128-131	zona pellucida glycoprotein 3	Mus musculus	156-159
1839890-0	1991	Branched saccharides formed by the action of His-modified cyclodextrin glycosyltransferase from Klebsiella pneumoniae M 5 al on starch.	Histidine	45-48	hydroquinone glucosyltransferase-like	Solanum tuberosum	71-90
1918039-0	1991	Modification of histidine 56 in adrenodoxin with diethyl pyrocarbonate inhibited the interaction with cytochrome P-450scc and adrenodoxin reductase.	Histidine	16-25	ferredoxin reductase	Bos taurus	126-147
1826736-7	1991	Similarly, substitution of residue histidine 51 of the NS3 polyprotein segment, which is predicted to be part of the protease catalytic centre, with an alanine residue, blocks the processing of the polyprotein in vitro.	Histidine	35-44	KRAS proto-oncogene, GTPase	Homo sapiens	55-58
1999271-2	1991	A peptide corresponding to the COOH-terminal domain of the GLUT1 glucose transporter (Thr-Pro-Glu-Glu-Leu-Phe-His-Pro-Leu-Gly-Ala-Asp-Ser-Gln-Val) was synthesized and conjugated to keyhole limpet hemocyanin through the NH2-terminal of the peptide.	Histidine	110-113	solute carrier family 2 member 1	Homo sapiens	59-64
2001710-1	1991	The histidine at position 55 of the amino acid sequence of the Escherichia coli single-stranded DNA binding protein was replaced by tyrosine, glutamic acid, lysine, phenylalanine, and isoleucine.	Histidine	4-13	single-stranded DNA-binding protein	Escherichia coli	80-115
1901988-7	1991	In addition, we show that a conserved histidine residue, located 7 amino acids (i.e., two alpha-helical turns) C-terminally to the 5th leucine in Fos and Jun, is also important for complex formation.	Histidine	38-47	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	146-149
1900206-8	1991	The activity of this enzyme was decreased by the serine esterase inhibitors phenylmethyl-sulfonyl fluoride and N-tosyl-L-phenylalanine chloromethyl ketone and by the histidine modifier diethyl pyrocarbonate, suggesting that CoA-IT may belong to a family of acyltransferase enzymes typified by LCAT.	Histidine	166-175	lecithin-cholesterol acyltransferase	Homo sapiens	293-297
1988934-4	1991	Within this region 58%, 65%, and 50% of the amino acids of PC3 are identical to those of the aligned PC2, furin, and kex2 sequences, respectively, and the catalytically important Asp, His, and Ser residues are all conserved.	Histidine	184-187	proprotein convertase subtilisin/kexin type 1	Mus musculus	59-62
1846136-10	1991	A comparison of the arrangement of heme binding sites and coordinated histidines in the amino acid sequences of cytochrome c3 and Hmc from D. vulgaris Hildenborough suggests that the latter contains three cytochrome c3-like domains.	Histidine	70-80	hmcA	Desulfovibrio vulgaris str. Hildenborough	130-133
2046459-0	1991	Intranasal activity of the growth hormone releasing peptide His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 in conscious dogs.	Histidine	60-63	somatotropin	Canis lupus familiaris	27-41
2046459-1	1991	This series of experiments was conducted to evaluate the growth hormone (GH) releasing activity of intranasally administered His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 (GHRP-6, SK&amp;F 110679) in conscious dogs.	Histidine	125-128	somatotropin	Canis lupus familiaris	57-71
1699942-3	1990	The cDNA encodes a proline-, serine-, and glycine-rich nuclear protein designated Nup475 of 319 amino acids that contains two tandemly repeated cysteine- and histidine-containing sequences (CX8CX5CX3H) suggestive of a novel heavy metal-binding domain.	Histidine	158-167	zinc finger protein 36	Mus musculus	82-88
2226832-6	1990	Despite these similarities, CAP37 is not a serine proteinase because the active site residues serine and histidine are replaced.	Histidine	105-114	azurocidin 1	Homo sapiens	28-33
2176836-9	1990	It confirms that an important feature of the cytochrome c peroxidase structure is at least partial, and probably full, imidazolate character for the proximal histidine (His-175).	Histidine	158-167	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	45-68
2176836-9	1990	It confirms that an important feature of the cytochrome c peroxidase structure is at least partial, and probably full, imidazolate character for the proximal histidine (His-175).	Histidine	169-172	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	45-68
2350181-10	1990	These results suggest that with NEP, binding interactions at the active site involve one or more histidine residues while with thermolysin binding involves an active site glutamic acid residue.	Histidine	97-106	membrane metallo-endopeptidase	Rattus norvegicus	32-35
1691825-4	1990	In addition, Isl-1, like the lin-11 and mec-3 gene products, contains a novel Cys-His domain which is reminiscent of known metal-binding regions.	Histidine	82-85	Protein lin-11	Caenorhabditis elegans	29-35
2158889-17	1990	The histidine residue at position 132 of rat heme oxygenase-1 and the residues (Lys128-Arg136) flanking His132 were conserved in all three enzymes, as well as in the corresponding portion of a fourth less highly similar rat enzyme, heme oxygenase-2.	Histidine	4-13	heme oxygenase 1	Rattus norvegicus	45-61
1692573-3	1990	Effective separations of fetal-derived AFP variants was accomplished within 20 min under mild conditions with an L-histidine buffer.	Histidine	113-124	alpha fetoprotein	Mus musculus	39-42
1688433-2	1990	Analysis of a 953-base pair cDNA that encodes MMCP-2 revealed that this serine protease is a basically charged protein, possessing the histidine-aspartic acid-serine charge relay system that is characteristic of other serine proteases.	Histidine	135-144	mast cell protease 2	Mus musculus	46-52
1688433-2	1990	Analysis of a 953-base pair cDNA that encodes MMCP-2 revealed that this serine protease is a basically charged protein, possessing the histidine-aspartic acid-serine charge relay system that is characteristic of other serine proteases.	Histidine	135-144	complement component 1, s subcomponent 1	Mus musculus	72-87
25575548-9	2015	CONCLUSIONS: Three LoF mutations in HAL were associated with increased histidine levels, which in turn were shown to be inversely related to the risk of CHD among both African Americans and European Americans.	Histidine	71-80	histidine ammonia-lyase	Homo sapiens	36-39
33620265-2	2021	Taking advantage of the overexpressed CD44 receptor and mild acidic microenvironment of tumour cells, CD44-targeted pH-responsive micelles based on the self-assembly of histidine-hyaluronic acid-dodecylamine (His-HA-DA) were prepared for the delivery of doxorubicin (DOX).	Histidine	169-178	CD44 molecule (Indian blood group)	Homo sapiens	38-42
33620265-2	2021	Taking advantage of the overexpressed CD44 receptor and mild acidic microenvironment of tumour cells, CD44-targeted pH-responsive micelles based on the self-assembly of histidine-hyaluronic acid-dodecylamine (His-HA-DA) were prepared for the delivery of doxorubicin (DOX).	Histidine	169-178	CD44 molecule (Indian blood group)	Homo sapiens	102-106
34562450-4	2021	Here we identified mammalian seven-beta-strand methyltransferase METTL9 as a histidine Npi-methyltransferase by siRNA screening coupled with methylhistidine analysis using liquid chromatography-tandem mass spectrometry.	Histidine	77-86	methyltransferase like 9	Homo sapiens	65-71
34562450-6	2021	METTL9 does not affect the heterodimer formation of S100A9 and S100A8, although Npi-methylation of S100A9 at His-107 overlaps with a zinc-binding site, attenuating its affinity for zinc.	Histidine	109-112	S100 calcium binding protein A9	Homo sapiens	99-105
34627325-17	2021	Molecular docking study further supported that p-hydroxybenzoic acid, cedar acid, shikimic acid, salicylic acid, nicotinic acid, linalool, and histidine can be well binding with NOS3, SRC, PI3K, and AKT.	Histidine	143-152	nitric oxide synthase 3	Rattus norvegicus	178-182
34627325-17	2021	Molecular docking study further supported that p-hydroxybenzoic acid, cedar acid, shikimic acid, salicylic acid, nicotinic acid, linalool, and histidine can be well binding with NOS3, SRC, PI3K, and AKT.	Histidine	143-152	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	184-187
34436882-5	2021	Herein, we report the discovery and hit-to-lead optimization of first-in-class Nln activators based on histidine-containing dipeptide hits identified from a virtual screen.	Histidine	103-112	neurolysin (metallopeptidase M3 family)	Mus musculus	79-82
34312718-9	2021	We observed that B12 and berberine could induce a disparate conformational change in regions Gly250-Asp258 located on the His-RXRalpha/LBD domain.	Histidine	122-125	retinoid X receptor alpha	Homo sapiens	126-134
35346814-2	2022	This biogenic amine is fermented by microorganisms from histidine through the activity of histidine decarboxylase.	Histidine	56-65	Histidine decarboxylase	Drosophila melanogaster	90-113
35503584-5	2022	His-BRCC3 plasmid was constructed by cloning the BRCC3 gene into pGEX-6P-1 vector, and then His-BRCC3 fusion protein was induced with isopropyl beta-d-1-thiogalactopyranoside and purified using His-Tag affinity chromatography purification agarose.	Histidine	194-197	BRCA1/BRCA2-containing complex subunit 3	Homo sapiens	4-9
35503584-5	2022	His-BRCC3 plasmid was constructed by cloning the BRCC3 gene into pGEX-6P-1 vector, and then His-BRCC3 fusion protein was induced with isopropyl beta-d-1-thiogalactopyranoside and purified using His-Tag affinity chromatography purification agarose.	Histidine	194-197	BRCA1/BRCA2-containing complex subunit 3	Homo sapiens	49-54
35503584-5	2022	His-BRCC3 plasmid was constructed by cloning the BRCC3 gene into pGEX-6P-1 vector, and then His-BRCC3 fusion protein was induced with isopropyl beta-d-1-thiogalactopyranoside and purified using His-Tag affinity chromatography purification agarose.	Histidine	194-197	BRCA1/BRCA2-containing complex subunit 3	Homo sapiens	96-101
35229720-3	2022	However, little is known about how histidine is presented to Hdc as a precursor.	Histidine	35-44	Histidine decarboxylase	Drosophila melanogaster	61-64