PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
3337830-1	1988	Koningic acid, a sesquiterpene antibiotic, is a specific inhibitor of the enzyme glyceraldehyde-3-phosphate dehydrogenase (D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating), EC 1.2.1.12).	Sesquiterpenes	17-30	glyceraldehyde-3-phosphate dehydrogenase	Oryctolagus cuniculus	81-121
4792101-0	1973	Studies on a sesquiterpene antibiotic, compound A-2,minor component from Myrotecium.	Sesquiterpenes	13-26	ATPase H+ transporting V0 subunit a2	Homo sapiens	48-51
7219206-4	1980	K-76 is a sesquiterpene compound and it can be oxidized to a monocarboxylic derivative (K-76 COOH), the sodium salt of which is very soluble and much less toxic than K-76.	Sesquiterpenes	10-23	keratin 76	Homo sapiens	0-4
33550070-4	2021	Four sesquiterpene-based LSD1 inhibitors were efficiently obtained with an inhibition ratio equal to or less than that of the positive control drug.	Sesquiterpenes	5-18	lysine demethylase 1A	Homo sapiens	25-29
32364046-5	2021	Galbanic acid as a natural compound with a sesquiterpene coumarin scaffold is a weak inhibitor of AChE.	Sesquiterpenes	43-56	acetylcholinesterase (Cartwright blood group)	Homo sapiens	98-102
33938102-2	2021	Here we developed a modular in vitro platform for the continuous conversion of CO 2 into complex multi-carbon compounds, such as monoterpenes (C10), sesquiterpenes (C15) and polyketides.	Sesquiterpenes	149-163	placenta associated 8	Homo sapiens	165-168
33199492-6	2021	Both in vitro and in vivo studies showed significantly enhanced sensitivity to the sesquiterpene irofulven in cells harboring specific clinically observed heterozygous mutations in ERCC2 or ERCC3.	Sesquiterpenes	83-96	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	181-186
33199492-6	2021	Both in vitro and in vivo studies showed significantly enhanced sensitivity to the sesquiterpene irofulven in cells harboring specific clinically observed heterozygous mutations in ERCC2 or ERCC3.	Sesquiterpenes	83-96	ERCC excision repair 3, TFIIH core complex helicase subunit	Homo sapiens	190-195
33839581-0	2021	Butyrolactone and sesquiterpene derivatives as inhibitors of iNOS from the roots of Lindera glauca.	Sesquiterpenes	18-31	nitric oxide synthase 2, inducible	Mus musculus	61-65
33956362-0	2021	An anti-oxidant sesquiterpene inhibits osteoclastogenesis via blocking IPMK/TRAF6 and counteracts OVX-induced osteoporosis in mice.	Sesquiterpenes	16-29	inositol polyphosphate multikinase	Mus musculus	71-75
33956362-0	2021	An anti-oxidant sesquiterpene inhibits osteoclastogenesis via blocking IPMK/TRAF6 and counteracts OVX-induced osteoporosis in mice.	Sesquiterpenes	16-29	TNF receptor-associated factor 6	Mus musculus	76-81
33917960-0	2021	Sesquiterpene-Loaded Co-Polymer Hybrid Nanoparticle Effects on Human Mast Cell Surface Receptor Expression, Granule Contents, and Degranulation.	Sesquiterpenes	0-13	CD177 molecule	Homo sapiens	74-95
33550070-6	2021	These four compounds are the first sesquiterpene-based natural LSD1 inhibitors to be characterized.	Sesquiterpenes	35-48	lysine demethylase 1A	Homo sapiens	63-67
33550070-7	2021	Our findings provide a new molecular framework for studying LSD1 inhibitors and offer a template for designing more sesquiterpene-based LSD1 inhibitors with potential antitumor activity.	Sesquiterpenes	116-129	lysine demethylase 1A	Homo sapiens	136-140
33010370-4	2020	Herein, we obtained 5 sesquiterpenoids, named curzerenone, curdione, furanodienone, curcumol and germacrone with TMEM16A inhibition and revealed their mechanism of action by fluorescent and electrophysiological assays.	Sesquiterpenes	22-38	anoctamin 1	Homo sapiens	113-120
33594068-7	2021	Second, depleting hexokinase-2, a key protein in glucose signalling transduction, lifts glucose repression and boosts production of sesquiterpene (C15) nerolidol to 3.5 g L-1 in flask cultivation.	Sesquiterpenes	132-145	hexokinase 2	Saccharomyces cerevisiae S288C	18-30
33673039-5	2021	Monoterpenes and sesquiterpenes with acyclic (C10 and C15), p-menthane, pinane, bisabolane, germacrane, caryophyllane, cadinane, and aromadendrane skeleton-types, were the primary constituents.	Sesquiterpenes	17-31	homeobox C10	Homo sapiens	46-49
33673039-5	2021	Monoterpenes and sesquiterpenes with acyclic (C10 and C15), p-menthane, pinane, bisabolane, germacrane, caryophyllane, cadinane, and aromadendrane skeleton-types, were the primary constituents.	Sesquiterpenes	17-31	placenta associated 8	Homo sapiens	54-57
33447946-6	2021	A principal component analysis of these aphid performance parameters and terpene production in the trichome mutants indicated that longevity and fecundity of M. euphorbiae were negatively correlated with production of the TPS12-derived sesquiterpenes beta-caryophyllene and alpha-humulene.	Sesquiterpenes	236-250	beta caryophyllene/humulene synthase	Solanum lycopersicum	222-227
33447946-10	2021	While TPS12-derived sesquiterpenes contribute to host plant resistance against M. euphorbiae, TPS20-derived monoterpenes appear to be exploited as cue for host plant orientation by aphids.	Sesquiterpenes	20-34	beta caryophyllene/humulene synthase	Solanum lycopersicum	6-11
33100202-9	2021	Some natural/plant derived compounds including fatty acids, sesquiterpenes, phenolic compounds, anthocyanins, isoquinoline and indole alkaloids were also reported as potent FFAR1 agonists.	Sesquiterpenes	60-74	free fatty acid receptor 1	Homo sapiens	173-178
31981749-14	2020	ERK, NF-kappaB and PI3K/Akt pathways accounted for the anti-inflammatory role of SESLA with the stimulation of LPS.	Sesquiterpenes	81-86	mitogen-activated protein kinase 1	Mus musculus	0-3
32814173-6	2020	IQ, 4,9-friedodrimane-type sesquiterpenoid isolated from the marine sponge, repressed the expression of angiogenic/inflammatory factors and restored the expression of E-cadherin in retinal pigment epithelial cells by inhibiting the Wnt/beta-catenin pathway.	Sesquiterpenes	27-42	cadherin 1	Homo sapiens	167-177
32814173-6	2020	IQ, 4,9-friedodrimane-type sesquiterpenoid isolated from the marine sponge, repressed the expression of angiogenic/inflammatory factors and restored the expression of E-cadherin in retinal pigment epithelial cells by inhibiting the Wnt/beta-catenin pathway.	Sesquiterpenes	27-42	catenin beta 1	Homo sapiens	236-248
32823063-4	2020	Remarkably, sesquiterpenes of the Pelorol family, which we previously described as allosteric activators of SHIP1 phosphatase activity, could induce SHIP1/STAT3 complex formation in cells and mimic the anti-inflammatory action of IL10 in a mouse model of colitis.	Sesquiterpenes	12-26	inositol polyphosphate-5-phosphatase D	Mus musculus	108-113
32823063-4	2020	Remarkably, sesquiterpenes of the Pelorol family, which we previously described as allosteric activators of SHIP1 phosphatase activity, could induce SHIP1/STAT3 complex formation in cells and mimic the anti-inflammatory action of IL10 in a mouse model of colitis.	Sesquiterpenes	12-26	inositol polyphosphate-5-phosphatase D	Mus musculus	149-154
32823063-4	2020	Remarkably, sesquiterpenes of the Pelorol family, which we previously described as allosteric activators of SHIP1 phosphatase activity, could induce SHIP1/STAT3 complex formation in cells and mimic the anti-inflammatory action of IL10 in a mouse model of colitis.	Sesquiterpenes	12-26	signal transducer and activator of transcription 3	Mus musculus	155-160
32823063-4	2020	Remarkably, sesquiterpenes of the Pelorol family, which we previously described as allosteric activators of SHIP1 phosphatase activity, could induce SHIP1/STAT3 complex formation in cells and mimic the anti-inflammatory action of IL10 in a mouse model of colitis.	Sesquiterpenes	12-26	interleukin 10	Mus musculus	230-234
32573211-1	2020	We report a concise, stereocontrolled synthesis of the neurotoxic sesquiterpenoid (-)-picrotoxinin (1, PXN).	Sesquiterpenes	66-81	paxillin	Homo sapiens	103-106
32747456-6	2020	We then performed whole-cell patch-clamp electrophysiology and observed farnesene-induced inward currents in ventral tegmental area (VTA) putative dopamine neurons that were blocked by the nAChR antagonist, DhbetaE.	Sesquiterpenes	72-81	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	189-194
32747456-7	2020	While the amplitudes of farnesene-induced currents are ~30% of nicotine"s efficacy, this indicates the potential for some ENDS flavorants to stimulate nAChR function.	Sesquiterpenes	24-33	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	151-156
32747456-10	2020	Consequently, these data show that the green apple flavorant, farnesene, causes reward-related behavior without nicotine through changes in nAChR stoichiometry that results in an enhanced effect of nicotine on VTA dopamine neurons.	Sesquiterpenes	62-71	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	140-145
32521813-7	2020	Sesquiterpene-mediated dysregulation of both cholesterol and lipid metabolism was observed, during which these compounds influenced the protein expression of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) and sterol regulatory element-binding protein 2 (SREBP-2), as well as the mRNA expression of HMGCR, CYP19A1, PLIN2, FASN, SCD, ACACB, and GPAM genes.	Sesquiterpenes	0-13	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	158-198
32521813-7	2020	Sesquiterpene-mediated dysregulation of both cholesterol and lipid metabolism was observed, during which these compounds influenced the protein expression of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) and sterol regulatory element-binding protein 2 (SREBP-2), as well as the mRNA expression of HMGCR, CYP19A1, PLIN2, FASN, SCD, ACACB, and GPAM genes.	Sesquiterpenes	0-13	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	200-205
32521813-7	2020	Sesquiterpene-mediated dysregulation of both cholesterol and lipid metabolism was observed, during which these compounds influenced the protein expression of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) and sterol regulatory element-binding protein 2 (SREBP-2), as well as the mRNA expression of HMGCR, CYP19A1, PLIN2, FASN, SCD, ACACB, and GPAM genes.	Sesquiterpenes	0-13	sterol regulatory element binding transcription factor 2	Homo sapiens	211-254
32521813-7	2020	Sesquiterpene-mediated dysregulation of both cholesterol and lipid metabolism was observed, during which these compounds influenced the protein expression of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) and sterol regulatory element-binding protein 2 (SREBP-2), as well as the mRNA expression of HMGCR, CYP19A1, PLIN2, FASN, SCD, ACACB, and GPAM genes.	Sesquiterpenes	0-13	sterol regulatory element binding transcription factor 2	Homo sapiens	256-263
32521813-7	2020	Sesquiterpene-mediated dysregulation of both cholesterol and lipid metabolism was observed, during which these compounds influenced the protein expression of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) and sterol regulatory element-binding protein 2 (SREBP-2), as well as the mRNA expression of HMGCR, CYP19A1, PLIN2, FASN, SCD, ACACB, and GPAM genes.	Sesquiterpenes	0-13	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	300-305
32521813-7	2020	Sesquiterpene-mediated dysregulation of both cholesterol and lipid metabolism was observed, during which these compounds influenced the protein expression of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) and sterol regulatory element-binding protein 2 (SREBP-2), as well as the mRNA expression of HMGCR, CYP19A1, PLIN2, FASN, SCD, ACACB, and GPAM genes.	Sesquiterpenes	0-13	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	307-314
32521813-7	2020	Sesquiterpene-mediated dysregulation of both cholesterol and lipid metabolism was observed, during which these compounds influenced the protein expression of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) and sterol regulatory element-binding protein 2 (SREBP-2), as well as the mRNA expression of HMGCR, CYP19A1, PLIN2, FASN, SCD, ACACB, and GPAM genes.	Sesquiterpenes	0-13	perilipin 2	Homo sapiens	316-321
32521813-7	2020	Sesquiterpene-mediated dysregulation of both cholesterol and lipid metabolism was observed, during which these compounds influenced the protein expression of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) and sterol regulatory element-binding protein 2 (SREBP-2), as well as the mRNA expression of HMGCR, CYP19A1, PLIN2, FASN, SCD, ACACB, and GPAM genes.	Sesquiterpenes	0-13	fatty acid synthase	Homo sapiens	323-327
32521813-7	2020	Sesquiterpene-mediated dysregulation of both cholesterol and lipid metabolism was observed, during which these compounds influenced the protein expression of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) and sterol regulatory element-binding protein 2 (SREBP-2), as well as the mRNA expression of HMGCR, CYP19A1, PLIN2, FASN, SCD, ACACB, and GPAM genes.	Sesquiterpenes	0-13	acetyl-CoA carboxylase beta	Homo sapiens	334-339
32521813-7	2020	Sesquiterpene-mediated dysregulation of both cholesterol and lipid metabolism was observed, during which these compounds influenced the protein expression of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) and sterol regulatory element-binding protein 2 (SREBP-2), as well as the mRNA expression of HMGCR, CYP19A1, PLIN2, FASN, SCD, ACACB, and GPAM genes.	Sesquiterpenes	0-13	glycerol-3-phosphate acyltransferase, mitochondrial	Homo sapiens	345-349
32248516-0	2020	A new sesquiterpenoid from the shoots of Iranian Daphne mucronata Royle with selective inhibition of STAT3 and Smad3/4 cancer-related signaling pathways.	Sesquiterpenes	6-21	signal transducer and activator of transcription 3	Homo sapiens	101-106
32248516-0	2020	A new sesquiterpenoid from the shoots of Iranian Daphne mucronata Royle with selective inhibition of STAT3 and Smad3/4 cancer-related signaling pathways.	Sesquiterpenes	6-21	SMAD family member 3	Homo sapiens	111-118
32248516-14	2020	The new sesquiterpene was evaluated for the luciferase assay on 14 main cancer-related signaling pathways and showed selective inhibition of STAT3/IL6, and Smad/ TGF-beta transcription factors.	Sesquiterpenes	8-21	signal transducer and activator of transcription 3	Homo sapiens	141-146
32248516-14	2020	The new sesquiterpene was evaluated for the luciferase assay on 14 main cancer-related signaling pathways and showed selective inhibition of STAT3/IL6, and Smad/ TGF-beta transcription factors.	Sesquiterpenes	8-21	interleukin 6	Homo sapiens	147-150
32248516-14	2020	The new sesquiterpene was evaluated for the luciferase assay on 14 main cancer-related signaling pathways and showed selective inhibition of STAT3/IL6, and Smad/ TGF-beta transcription factors.	Sesquiterpenes	8-21	transforming growth factor alpha	Homo sapiens	162-170
32252311-8	2020	This evidence highlighted a possible role of STAT3 as a final effector of a complex network regulated by beta-caryophyllene, which leads to an enhanced doxorubicin-sensitivity of cholangiocarcinoma cells and a lowered chemotherapy toxicity in nonmalignant cholangiocytes, thus strengthening the interest for this natural sesquiterpene as a dual-acting chemosensitizing and chemopreventive agent.	Sesquiterpenes	321-334	signal transducer and activator of transcription 3	Homo sapiens	45-50
31981749-14	2020	ERK, NF-kappaB and PI3K/Akt pathways accounted for the anti-inflammatory role of SESLA with the stimulation of LPS.	Sesquiterpenes	81-86	thymoma viral proto-oncogene 1	Mus musculus	24-27
31963614-0	2020	Potentiation of Low-Dose Doxorubicin Cytotoxicity by Affecting P-Glycoprotein through Caryophyllane Sesquiterpenes in HepG2 Cells: an in Vitro and in Silico Study.	Sesquiterpenes	86-114	ATP binding cassette subfamily B member 1	Homo sapiens	63-77
32022458-2	2020	Sesquiterpene lactones (SLs) consist of a large group of plant secondary metabolites, and belong to C15 terpenoids group.	Sesquiterpenes	0-22	placenta associated 8	Homo sapiens	100-103
32022458-2	2020	Sesquiterpene lactones (SLs) consist of a large group of plant secondary metabolites, and belong to C15 terpenoids group.	Sesquiterpenes	24-27	placenta associated 8	Homo sapiens	100-103
31828806-0	2020	Sesquiterpene glucosylation mediated by glucosyltransferase UGT91Q2 is involved in the modulation of cold stress tolerance in tea plants.	Sesquiterpenes	0-13	solute carrier family 35 member A2	Homo sapiens	60-67
31940436-4	2020	To alter flux from predominant triterpenoid/steroid biosynthesis to sesquiterpenoid production, expression of ERG9 (encoding yeast squalene synthase) was depressed by replacing its innate promotor with PHXT1 and fermenting the resulting strains in galactose-rich media.	Sesquiterpenes	68-83	bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase	Saccharomyces cerevisiae S288C	110-114
31963614-4	2020	Also, the direct interaction of caryophyllene sesquiterpenes with P-gp was characterized by molecular docking and dynamic simulation studies.	Sesquiterpenes	32-60	ATP binding cassette subfamily B member 1	Homo sapiens	66-70
31963614-6	2020	Also, an increased intracellular accumulation of doxorubicin and rhodamine 123 induced by caryophyllane sesquiterpenes was found, thus suggesting their interference with P-gp function.	Sesquiterpenes	90-118	ATP binding cassette subfamily B member 1	Homo sapiens	170-174
31963614-8	2020	Docking studies found that the binding site of caryophyllane sesquiterpene was next to the ATP binding domain of P-gp and that beta-caryophyllene possessed the stronger binding affinity and higher inhibition potential calculated by MM-PBSA.	Sesquiterpenes	47-74	ATP binding cassette subfamily B member 1	Homo sapiens	113-117
31472273-6	2019	RESULTS: After intraperitoneal treatment for one week, DSS-induced colitis was significantly reduced in mice treated with either of both sesquiterpenes lactones, as witnessed by reduced cellular infiltration, tissue damage, TNF-alpha production, and enhanced production of TGF-beta.	Sesquiterpenes	137-151	tumor necrosis factor	Mus musculus	224-233
31472273-6	2019	RESULTS: After intraperitoneal treatment for one week, DSS-induced colitis was significantly reduced in mice treated with either of both sesquiterpenes lactones, as witnessed by reduced cellular infiltration, tissue damage, TNF-alpha production, and enhanced production of TGF-beta.	Sesquiterpenes	137-151	transforming growth factor, beta 1	Mus musculus	273-281
31628167-3	2019	TPS11 was previously reported to generate a blend of sesquiterpenes.	Sesquiterpenes	53-67	trehalose phosphatase/synthase 11	Arabidopsis thaliana	0-5
31628167-5	2019	Analysis of headspace and soluble metabolites of CYP706A3 insertion and overexpression mutants indicates that CYP706A3-mediated metabolism largely suppresses sesquiterpene and most monoterpene emission from opening flowers, and generates terpene oxides retained in floral tissues.	Sesquiterpenes	158-171	cytochrome P450, family 706, subfamily A, polypeptide 3	Arabidopsis thaliana	49-57
31628167-5	2019	Analysis of headspace and soluble metabolites of CYP706A3 insertion and overexpression mutants indicates that CYP706A3-mediated metabolism largely suppresses sesquiterpene and most monoterpene emission from opening flowers, and generates terpene oxides retained in floral tissues.	Sesquiterpenes	158-171	cytochrome P450, family 706, subfamily A, polypeptide 3	Arabidopsis thaliana	110-118
31628167-6	2019	In flower buds, concerted expression of TPS11 and CYP706A3 also suppresses volatile emission and generates soluble sesquiterpene oxides.	Sesquiterpenes	115-135	trehalose phosphatase/synthase 11	Arabidopsis thaliana	40-45
31628167-6	2019	In flower buds, concerted expression of TPS11 and CYP706A3 also suppresses volatile emission and generates soluble sesquiterpene oxides.	Sesquiterpenes	115-135	cytochrome P450, family 706, subfamily A, polypeptide 3	Arabidopsis thaliana	50-58
31755290-8	2019	Hence, the interaction of drugs metabolized by CYP3A4 with sesquiterpenes is less probable.	Sesquiterpenes	59-73	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	47-53
31784542-12	2019	The NF-kappaB-p65 nuclear translocation induced by okadaic acid (OA) was suppressed by the sesquiterpene.	Sesquiterpenes	91-104	RELA proto-oncogene, NF-kB subunit	Homo sapiens	4-17
31755290-2	2019	Here, focus is given on interactions of three sesquiterpenes (beta-caryophyllene oxide (CAO), trans-nerolidol (tNER) and farnesol (FAR)) with CYP3A4.	Sesquiterpenes	46-60	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	142-148
31755290-6	2019	The docking experiments showed that the studied sesquiterpenes (CAO and tNER) bound to the CYP3A4 active site cause a significant decrease of binding affinity of substrates tested which corresponded well to the inhibition studies.	Sesquiterpenes	48-62	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	91-97
31487883-6	2019	Proteomics analysis of Nicotiana benthamiana leaves expressing p22, and its F-box-like motif deletion mutant showed 228 differentially expressed proteins and five enriched Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways: ABC transporters, sesquiterpenoid and triterpenoid biosynthesis, ubiquitin-mediated proteolysis, riboflavin metabolism, and cysteine and methionine metabolism.	Sesquiterpenes	247-262	calcineurin like EF-hand protein 1	Homo sapiens	63-66
31540101-0	2019	Sesquiterpenes Are Agonists of the Pregnane X Receptor but Do Not Induce the Expression of Phase I Drug-Metabolizing Enzymes in the Human Liver.	Sesquiterpenes	0-14	nuclear receptor subfamily 1 group I member 2	Homo sapiens	35-54
31540101-6	2019	In the reporter gene assays, all sesquiterpenes significantly induced cytochrome P450 3A4 expression via pregnane X receptor interaction.	Sesquiterpenes	33-47	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	70-89
31540101-6	2019	In the reporter gene assays, all sesquiterpenes significantly induced cytochrome P450 3A4 expression via pregnane X receptor interaction.	Sesquiterpenes	33-47	nuclear receptor subfamily 1 group I member 2	Homo sapiens	105-124
31080076-3	2019	We find that parthenolide, as well as other related exocyclic methylene lactone-containing sesquiterpenes, covalently modify cysteine 427 of focal adhesion kinase 1 (FAK1), leading to impairment of FAK1-dependent signaling pathways and breast cancer cell proliferation, survival, and motility.	Sesquiterpenes	91-105	protein tyrosine kinase 2	Homo sapiens	141-164
31194954-1	2019	beta-2-himachalen-6-ol (HC), a major sesquiterpene isolated from the Lebanese wild carrot umbels, was shown to possess remarkable in vitro and in vivo anticancer activities.	Sesquiterpenes	37-50	hemoglobin, beta adult minor chain	Mus musculus	0-6
31080076-3	2019	We find that parthenolide, as well as other related exocyclic methylene lactone-containing sesquiterpenes, covalently modify cysteine 427 of focal adhesion kinase 1 (FAK1), leading to impairment of FAK1-dependent signaling pathways and breast cancer cell proliferation, survival, and motility.	Sesquiterpenes	91-105	protein tyrosine kinase 2	Homo sapiens	166-170
31245644-3	2019	In this study, we used the ethanol-induced loss of righting reflex (LORR) assay to assess potency differences between the sesquiterpene phytochemical beta-caryophyllene (BCP) and its derivative caryophyllene oxide (BCPO).	Sesquiterpenes	122-135	opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan)	Mus musculus	150-174
30919065-1	2019	MAIN CONCLUSION: Mouse FIT2 protein redirects the cytoplasmic terpene biosynthetic machinery to lipid-droplet-forming domains in the ER and this relocalization supports the efficient compartmentalization and accumulation of sesquiterpenes in plant cells.	Sesquiterpenes	224-238	fat storage-inducing transmembrane protein 2	Mus musculus	23-27
30466970-3	2018	HYPOTHESIS/PURPOSE: The sesquiterpene lactones (SLs) coronopilin and damsin, which are major secondary metabolites of A. arborescens, have anti-inflammatory activity by attenuation of IL-6 and MCP-1 expression and inhibition of NF-kappaB in human dermal fibroblasts (HDFa) and human keratinocytes (HaCaT).	Sesquiterpenes	24-37	interleukin 6	Mus musculus	184-188
30689998-1	2019	Galbanic acid (GBA) is known a sesquiterpene coumarin to have apoptotic, anti-hypoxic, anti-proliferative, anti-hepatitis, anti-angiogenic, anti-bacteria and anti-thrombotic effects.	Sesquiterpenes	31-44	glucosylceramidase beta	Homo sapiens	15-18
30518626-5	2018	SlMYC1 functions as a positive regulator of monoterpene biosynthesis in both leaf and stem trichomes but as a negative regulator of sesquiterpene biosynthesis in stem trichomes.	Sesquiterpenes	132-145	transcription factor MYC1	Solanum lycopersicum	0-6
30466970-3	2018	HYPOTHESIS/PURPOSE: The sesquiterpene lactones (SLs) coronopilin and damsin, which are major secondary metabolites of A. arborescens, have anti-inflammatory activity by attenuation of IL-6 and MCP-1 expression and inhibition of NF-kappaB in human dermal fibroblasts (HDFa) and human keratinocytes (HaCaT).	Sesquiterpenes	24-37	mast cell protease 1	Mus musculus	193-198
29616391-7	2018	During the evaluation of the signaling pathways involved in these anti-neuroinflammatory effects, western blot analysis and DNA-binding activity assay revealed that the suppression of inflammatory reaction by these sesquiterpenes was mediated by the inactivation of nuclear factor-kappa B (NF-kappaB) pathway.	Sesquiterpenes	215-229	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	266-288
29098926-10	2018	Contrary, sesquiterpenes decreased NAD(P)H:quinone oxidoreductase 1 activity in small intestine.	Sesquiterpenes	10-24	NAD(P)H dehydrogenase, quinone 1	Mus musculus	35-67
30217259-0	2018	In vitro inhibitory properties of sesquiterpenes from Chloranthus serratus on cell motility via down-regulation of LIMK1 activation in human breast cancer.	Sesquiterpenes	34-48	LIM domain kinase 1	Homo sapiens	115-120
30217259-8	2018	RESULTS: we reported here that among the three sesquiterpenes, SERA showed significantly inhibition on LIMK1 activity, and the IC50 values on MDA-MB-231 and MDA-MB-468 cells were 3.14 muM and 4.64 muM, respectively.	Sesquiterpenes	47-61	LIM domain kinase 1	Homo sapiens	103-108
29902782-4	2018	Furthermore, overexpression of COQ1 in the same genetic context but with a mutated farnesyl pyrophosphate synthetase (erg20 mutation K197E), results in statistically significant higher levels of linalool (above 750 mug/L), geraniol, alpha-terpineol, and the sesquiterpenes, farnesol and nerolidol (total concentration of volatile isoprenoids surpasses 1300 mug/L).	Sesquiterpenes	258-272	trans-hexaprenyltranstransferase	Saccharomyces cerevisiae S288C	31-35
29616391-0	2018	Nardosinone-Type Sesquiterpenes from the Hexane Fraction of Nardostachys jatamansi Attenuate NF-kappaB and MAPK Signaling Pathways in Lipopolysaccharide-Stimulated BV2 Microglial Cells.	Sesquiterpenes	17-31	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	93-102
29616391-7	2018	During the evaluation of the signaling pathways involved in these anti-neuroinflammatory effects, western blot analysis and DNA-binding activity assay revealed that the suppression of inflammatory reaction by these sesquiterpenes was mediated by the inactivation of nuclear factor-kappa B (NF-kappaB) pathway.	Sesquiterpenes	215-229	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	290-299
29616391-6	2018	Moreover, these sesquiterpenes also attenuated the mRNA expression of pro-inflammatory cytokines including interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor-alpha (TNF-alpha) in LPS-induced BV2 microglial cells.	Sesquiterpenes	16-30	interleukin 1 beta	Mus musculus	107-124
29616391-8	2018	These sesquiterpenes also suppressed the phosphorylation of extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (MAPK) signaling pathways in LPS-stimulated BV2 microglial cells.	Sesquiterpenes	6-20	mitogen-activated protein kinase 1	Mus musculus	60-97
29616391-6	2018	Moreover, these sesquiterpenes also attenuated the mRNA expression of pro-inflammatory cytokines including interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor-alpha (TNF-alpha) in LPS-induced BV2 microglial cells.	Sesquiterpenes	16-30	interleukin 1 beta	Mus musculus	126-134
29616391-8	2018	These sesquiterpenes also suppressed the phosphorylation of extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (MAPK) signaling pathways in LPS-stimulated BV2 microglial cells.	Sesquiterpenes	6-20	mitogen-activated protein kinase 1	Mus musculus	99-102
29616391-6	2018	Moreover, these sesquiterpenes also attenuated the mRNA expression of pro-inflammatory cytokines including interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor-alpha (TNF-alpha) in LPS-induced BV2 microglial cells.	Sesquiterpenes	16-30	interleukin 6	Mus musculus	137-141
29616391-6	2018	Moreover, these sesquiterpenes also attenuated the mRNA expression of pro-inflammatory cytokines including interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor-alpha (TNF-alpha) in LPS-induced BV2 microglial cells.	Sesquiterpenes	16-30	tumor necrosis factor	Mus musculus	147-174
29616391-8	2018	These sesquiterpenes also suppressed the phosphorylation of extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (MAPK) signaling pathways in LPS-stimulated BV2 microglial cells.	Sesquiterpenes	6-20	mitogen-activated protein kinase 8	Mus musculus	105-128
29616391-6	2018	Moreover, these sesquiterpenes also attenuated the mRNA expression of pro-inflammatory cytokines including interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor-alpha (TNF-alpha) in LPS-induced BV2 microglial cells.	Sesquiterpenes	16-30	tumor necrosis factor	Mus musculus	176-185
29616391-8	2018	These sesquiterpenes also suppressed the phosphorylation of extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (MAPK) signaling pathways in LPS-stimulated BV2 microglial cells.	Sesquiterpenes	6-20	mitogen-activated protein kinase 8	Mus musculus	130-133
29616391-8	2018	These sesquiterpenes also suppressed the phosphorylation of extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (MAPK) signaling pathways in LPS-stimulated BV2 microglial cells.	Sesquiterpenes	6-20	mitogen-activated protein kinase 14	Mus musculus	140-143
29616391-9	2018	Taken together, these four nardosinone-type sesquiterpenes inhibited NF-kappaB- and MAPK-mediated inflammatory pathways, demonstrating their potential role in the treatment of neuroinflammation conditions.	Sesquiterpenes	44-58	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	69-78
30014756-10	2018	Our results indicate that bicyclic eremophilane-type petasite sesquiterpenes ZYFDC21 or ZYFDC22 inhibit maturation and activation of DC, and this activity is augmented upon PPARgamma activation.	Sesquiterpenes	62-76	peroxisome proliferator activated receptor gamma	Mus musculus	173-182
29676236-3	2018	OBJECTIVE: Evaluate the antidepressant-like activity of sesquiterpene compound beta-caryophyllene (BCP) for the possible contribution of the monoamine and hippocampal levels of brain-derived neurotrophic factor (BDNF).	Sesquiterpenes	56-69	brain derived neurotrophic factor	Mus musculus	212-216
29715454-1	2018	The sesquiterpene polygodial is an agonist of the transient receptor potential vanilloid 1 (TRPV1).	Sesquiterpenes	4-17	transient receptor potential cation channel subfamily V member 1	Homo sapiens	50-90
29715454-1	2018	The sesquiterpene polygodial is an agonist of the transient receptor potential vanilloid 1 (TRPV1).	Sesquiterpenes	4-17	transient receptor potential cation channel subfamily V member 1	Homo sapiens	92-97
30003747-11	2018	CONCLUSIONS: In brief, this study showed that farnesol -a naturally occurring sesquiterpene- exerts powerful antiproliferative activity via apoptosis induction, loss of MMP and downregulation of the expression levels of PI3K, p-PI3K and p-Akt proteins.	Sesquiterpenes	78-91	AKT serine/threonine kinase 1	Homo sapiens	239-242
29676236-3	2018	OBJECTIVE: Evaluate the antidepressant-like activity of sesquiterpene compound beta-caryophyllene (BCP) for the possible contribution of the monoamine and hippocampal levels of brain-derived neurotrophic factor (BDNF).	Sesquiterpenes	56-69	opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan)	Mus musculus	79-103
29066299-8	2018	Furthermore, beta-catenin expression and Wnt/beta-catenin signaling pathway induced by LPS in RAW264.7 was also significantly inhibited by alpha-humulene, one isomeric sesquiterpene of beta-elemene.	Sesquiterpenes	168-181	catenin (cadherin associated protein), beta 1	Mus musculus	13-25
29066299-8	2018	Furthermore, beta-catenin expression and Wnt/beta-catenin signaling pathway induced by LPS in RAW264.7 was also significantly inhibited by alpha-humulene, one isomeric sesquiterpene of beta-elemene.	Sesquiterpenes	168-181	catenin (cadherin associated protein), beta 1	Mus musculus	45-57
30014756-0	2018	Bicyclic eremophilane-type petasite sesquiterpenes potentiate peroxisome proliferator-activated receptor gamma activator-mediated inhibition of dendritic cells.	Sesquiterpenes	36-50	peroxisome proliferator activated receptor gamma	Mus musculus	62-110
30014756-4	2018	Since mucosal DCs are central in innate immune responses, we hypothesized that eremophilane-type petasite sesquiterpenes exerted their anti-inflammatory effects by inhibiting DC maturation and activation through PPARgamma.	Sesquiterpenes	106-120	peroxisome proliferator activated receptor gamma	Mus musculus	212-221
30014756-9	2018	We observed differences in the upregulation of surface expression of CD86, along with TNF, IL-6, and IL-12p70 released by DCs stimulated with LPS, when using combinations of bicyclic eremophilane-type petasite sesquiterpenes ZYFDC21 or ZYFDC22, and PPARgamma agonists, in particular the PPARgamma ligand 15d-PGJ2.	Sesquiterpenes	210-224	CD86 antigen	Mus musculus	69-73
29074051-3	2017	Therefore, the present study was designed to test the potential inhibitory effect of tree structurally relative sesquiterpenes beta-caryophyllene (CAR), beta-caryophyllene oxide (CAO) and alpha-humulene (HUM) on the activities of the main drug-metabolizing enzymes.	Sesquiterpenes	112-126	nuclear receptor subfamily 1, group I, member 3	Rattus norvegicus	127-145
28823078-6	2018	In our previous study, torilin, a major sesquiterpene of T. japonica, showed an inhibitory effect on melanin production in alpha-melanocyte stimulating hormone (alpha-MSH)-activated B16 melanoma cells.	Sesquiterpenes	40-53	pro-opiomelanocortin-alpha	Mus musculus	161-170
29150643-4	2017	beta-Eudesmol is an oxygenated sesquiterpene contained in medicinal or edible plants which activates TRPA1.	Sesquiterpenes	31-44	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	101-106
29209034-1	2017	The sesquiterpene (-)Englerin A (EA) is an organic compound from the plant Phyllanthus engleri which acts via heteromeric TRPC4/C1 channels to cause cytotoxicity in some types of cancer cell but not normal cells.	Sesquiterpenes	4-17	transient receptor potential cation channel subfamily C member 4	Homo sapiens	122-127
28972149-0	2017	Activity of the purified plant ABC transporter NtPDR1 is stimulated by diterpenes and sesquiterpenes involved in constitutive and induced defenses.	Sesquiterpenes	86-100	pleiotropic drug resistance protein 1	Nicotiana tabacum	47-53
28972149-7	2017	Interestingly, NtPDR1 was also stimulated by capsidiol, a sesquiterpene produced by N. tabacum upon pathogen attack.	Sesquiterpenes	58-71	pleiotropic drug resistance protein 1	Nicotiana tabacum	15-21
28972149-10	2017	In conclusion, we provide direct evidence of an interaction between the NtPDR1 transporter and its substrates and that NtPDR1 transports compounds involved in both constitutive (diterpenes) and induced (sesquiterpenes) plant defenses.	Sesquiterpenes	203-217	pleiotropic drug resistance protein 1	Nicotiana tabacum	72-78
28972149-10	2017	In conclusion, we provide direct evidence of an interaction between the NtPDR1 transporter and its substrates and that NtPDR1 transports compounds involved in both constitutive (diterpenes) and induced (sesquiterpenes) plant defenses.	Sesquiterpenes	203-217	pleiotropic drug resistance protein 1	Nicotiana tabacum	119-125
28872682-2	2017	Chemical analysis of DCOE led to the isolation of the beta-2-himachalen-6-ol (HC), major sesquiterpene with a potent anticancer activity against various colon, breast, brain and skin cancer cells.	Sesquiterpenes	89-102	hemoglobin, beta adult minor chain	Mus musculus	54-60
28643829-3	2017	Against expectations, millimolar CPA (a surface-active C10 keto-carboxylic acid possessing a rigid skeleton) is able to compete with 23 M bulk water for the CIs produced in the ozonolysis of sesquiterpene solutes by O3(g) on the surface of a water:acetonitrile solvent.	Sesquiterpenes	191-204	homeobox C10	Homo sapiens	55-58
28716406-7	2017	Detection of secondary metabolites indicated that the production of monoterpene and sesquiterpene were significantly decreased in SlCycB2-OE plants, which thus resulted in the reduction of the defense against Prodenia litura.	Sesquiterpenes	84-97	cyclin B2	Solanum lycopersicum	130-137
28684694-4	2017	beta-caryophyllene (BCP) is a natural bicyclic sesquiterpene that is an agonist of the cannabinoid type 2 receptor (CB2R).	Sesquiterpenes	47-60	cannabinoid receptor 2 (macrophage)	Mus musculus	87-114
28684694-4	2017	beta-caryophyllene (BCP) is a natural bicyclic sesquiterpene that is an agonist of the cannabinoid type 2 receptor (CB2R).	Sesquiterpenes	47-60	cannabinoid receptor 2 (macrophage)	Mus musculus	116-120
28338641-5	2017	The results showed significant inhibition of cytochromes P450 (namely CYP1A, CYP2B and CYP3A subfamilies) activities by all tested sesquiterpenes in rat as well as in human hepatic microsomes.	Sesquiterpenes	131-145	cytochrome P450 family 2 subfamily B member 7, pseudogene	Homo sapiens	77-82
28514148-5	2017	Therefore, separation of the active principles from the fermented broths was performed, and that has led to the isolation of eight new 5,5,5-tricyclic hirsutane-type sesquiterpenes, namely, chondroterpenes A-H (1-8), together with seven known analogues.	Sesquiterpenes	166-180	cytochrome P450, family 2, subfamily c, polypeptide 29	Mus musculus	206-214
28326625-4	2017	Moreover, the administration of the sesquiterpenes reversed scopolamine-induced cognitive impairments as assessed by Morris water, Y-maze, and the passive avoidance tests, and the compounds decreased acetylcholinesterase (AChE) activities in a dose-dependent manner.	Sesquiterpenes	36-50	acetylcholinesterase	Mus musculus	200-220
28326625-4	2017	Moreover, the administration of the sesquiterpenes reversed scopolamine-induced cognitive impairments as assessed by Morris water, Y-maze, and the passive avoidance tests, and the compounds decreased acetylcholinesterase (AChE) activities in a dose-dependent manner.	Sesquiterpenes	36-50	acetylcholinesterase	Mus musculus	222-226
28534941-0	2017	Two natural eudesmane-type sesquiterpenes from Laggera alata inhibit angiogenesis and suppress breast cancer cell migration through VEGF- and Angiopoietin 2-mediated signaling pathways.	Sesquiterpenes	27-41	vascular endothelial growth factor A	Homo sapiens	132-137
28534941-0	2017	Two natural eudesmane-type sesquiterpenes from Laggera alata inhibit angiogenesis and suppress breast cancer cell migration through VEGF- and Angiopoietin 2-mediated signaling pathways.	Sesquiterpenes	27-41	angiopoietin 2	Homo sapiens	142-156
28632185-7	2017	In resistant CEM/ADR cells, sesquiterpenes did not increase DOX efficacy, although they significantly increased accumulation of DOX (up to 10-times) and rhodamine-123 (substrate of efflux transporter ABCB1) within cancer cells.	Sesquiterpenes	28-42	ATP binding cassette subfamily B member 1	Homo sapiens	200-205
28338641-5	2017	The results showed significant inhibition of cytochromes P450 (namely CYP1A, CYP2B and CYP3A subfamilies) activities by all tested sesquiterpenes in rat as well as in human hepatic microsomes.	Sesquiterpenes	131-145	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	87-92
28338641-7	2017	The results indicate that acyclic sesquiterpenes might affect CYP1A, CYP2B and CYP3A mediated metabolism of concurrently administered drugs and other xenobiotics.	Sesquiterpenes	34-48	cytochrome P450 family 2 subfamily B member 7, pseudogene	Homo sapiens	69-74
28338641-7	2017	The results indicate that acyclic sesquiterpenes might affect CYP1A, CYP2B and CYP3A mediated metabolism of concurrently administered drugs and other xenobiotics.	Sesquiterpenes	34-48	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	79-84
27810398-3	2016	All isolated sesquiterpenes (1-22) were evaluated their activities by the assay of LPS-induced NO production on RAW264.7, of which compounds 2-4, 9, 10 and 17 produced significant inhibition of NO production with IC50 values ranging from 2.38 to 10.67muM.	Sesquiterpenes	13-27	latexin	Homo sapiens	251-254
27939849-8	2017	In order to re-direct carbon away from sterol production and towards the desired heterologous sesquiterpene, a novel protein destabilisation approach was developed for Erg9p.	Sesquiterpenes	94-107	bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase	Saccharomyces cerevisiae S288C	168-173
27285057-2	2016	While the biosynthesis of cyclic monoterpenes (C10) and sesquiterpenes (C15) most often involves enzymes with alpha or alphabeta domain architecture, the biosynthesis of cyclic diterpenes (C20), sesterterpenes (C25), and triterpenes (C30) can involve enzymes with alpha, alphaalpha, betagamma, or alphabetagamma domain architecture.	Sesquiterpenes	56-70	placenta associated 8	Homo sapiens	72-75
27462341-1	2016	Terpene synthases are responsible for synthesis of a large number of terpenes in plants using substrates provided by two distinct metabolic pathways, the mevalonate-dependent pathway that is located in cytosol and has been suggested to be responsible for synthesis of sesquiterpenes (C15), and 2-C-methyl-D-erythritol-4-phosphate pathway located in plastids and suggested to be responsible for the synthesis of hemi- (C5), mono- (C10), and diterpenes (C20).	Sesquiterpenes	268-282	placenta associated 8	Homo sapiens	284-287
27110875-7	2016	However, bilobalide, a sesquiterpene, showed anticonvulsant properties through the activation of glutamic acid decarboxylase (GAD) enzyme, which is a key enzyme in biosynthesis of GABA.	Sesquiterpenes	23-36	glutamate decarboxylase 1	Homo sapiens	97-124
27110875-7	2016	However, bilobalide, a sesquiterpene, showed anticonvulsant properties through the activation of glutamic acid decarboxylase (GAD) enzyme, which is a key enzyme in biosynthesis of GABA.	Sesquiterpenes	23-36	glutamate decarboxylase 1	Homo sapiens	126-129
27640747-0	2016	HHX-5, a derivative of sesquiterpene from Chinese agarwood, suppresses innate and adaptive immunity via inhibiting STAT signaling pathways.	Sesquiterpenes	23-36	signal transducer and activator of transcription 1	Homo sapiens	115-119
27421723-4	2016	Here, we characterized ZmTPS7 biochemically through recombinant expression in Escherichia coli and detected that it catalyzed formation of a blend of sesquiterpenes and sesquiterpenoid alcohols as the sesquiterpene synthase through GC-MS analysis.	Sesquiterpenes	150-164	Tau-cadinol synthase	Zea mays	23-29
27545438-3	2016	Bioassay-guided separation of the extract led to the isolation of a new TrxR1 inhibitor, dehydrocostus lactone (DHC), a guaiane-type sesquiterpene.	Sesquiterpenes	133-146	thioredoxin reductase 1	Homo sapiens	72-77
27240746-0	2016	beta-2-himachalen-6-ol: A novel anticancer sesquiterpene unique to the Lebanese wild carrot.	Sesquiterpenes	43-56	hemoglobin, beta adult minor chain	Mus musculus	0-6
27240746-5	2016	GC-MS and NMR spectroscopy revealed the identity of the major compound as beta-2-himachalen-6-ol, a novel sesquiterpene unique to the Lebanese wild carrot.	Sesquiterpenes	106-119	hemoglobin, beta adult minor chain	Mus musculus	74-80
27462341-1	2016	Terpene synthases are responsible for synthesis of a large number of terpenes in plants using substrates provided by two distinct metabolic pathways, the mevalonate-dependent pathway that is located in cytosol and has been suggested to be responsible for synthesis of sesquiterpenes (C15), and 2-C-methyl-D-erythritol-4-phosphate pathway located in plastids and suggested to be responsible for the synthesis of hemi- (C5), mono- (C10), and diterpenes (C20).	Sesquiterpenes	268-282	homeobox C10	Homo sapiens	430-433
27005600-3	2016	To isolate and identify the functional genes involved in the sesquiterpene biosynthesis of C. nobile L., a HMGS gene designated as CnHMGS (GenBank Accession No.	Sesquiterpenes	61-74	hydroxymethylglutaryl-CoA synthase	Saccharomyces cerevisiae S288C	107-111
27453282-3	2016	In this review we summarize how sesquiterpenes mediated Wnt, Shh, Notch and TRAIL induced signaling cascades.	Sesquiterpenes	32-46	sonic hedgehog signaling molecule	Homo sapiens	61-64
27453282-3	2016	In this review we summarize how sesquiterpenes mediated Wnt, Shh, Notch and TRAIL induced signaling cascades.	Sesquiterpenes	32-46	TNF superfamily member 10	Homo sapiens	76-81
26950613-2	2016	In the present study, we investigated the anti-inflammatory signaling pathway via the upregulation of heme oxygenase-1 (HO-1) in response to tussilagonone (TGN), a sesquiterpene compound isolated from T. farfara.	Sesquiterpenes	164-177	heme oxygenase 1	Mus musculus	102-118
26950613-2	2016	In the present study, we investigated the anti-inflammatory signaling pathway via the upregulation of heme oxygenase-1 (HO-1) in response to tussilagonone (TGN), a sesquiterpene compound isolated from T. farfara.	Sesquiterpenes	164-177	heme oxygenase 1	Mus musculus	120-124
26901188-7	2016	Treatment for 24 h resulted in significant increases in activity of caspases-3 and -9, indicating that the tested sesquiterpenes induced the mitochondrial pathway of apoptosis.	Sesquiterpenes	114-128	caspase 3	Homo sapiens	68-85
26253511-4	2015	The results revealed that GBA, as a biologically active sesquiterpene coumarin derivative, has an ability to bind strongly to MMP9.	Sesquiterpenes	56-69	glucosylceramidase beta	Homo sapiens	26-29
26388305-6	2015	Accordingly, floral sesquiterpene emission was suppressed in the cyp715a1 mutants.	Sesquiterpenes	20-33	cytochrome P450, family 715, subfamily A, polypeptide 1	Arabidopsis thaliana	65-73
26556352-0	2015	Natural Germacrane Sesquiterpenes Inhibit Osteoclast Formation, Bone Resorption, RANKL-Induced NF-kappaB Activation, and IkappaBalpha Degradation.	Sesquiterpenes	19-33	TNF superfamily member 11	Homo sapiens	81-86
26556352-0	2015	Natural Germacrane Sesquiterpenes Inhibit Osteoclast Formation, Bone Resorption, RANKL-Induced NF-kappaB Activation, and IkappaBalpha Degradation.	Sesquiterpenes	19-33	NFKB inhibitor alpha	Homo sapiens	121-133
26540043-10	2015	Alismol, a guaiane-type sesquiterpenes in Alisma orientale, inhibited GRP78 expression in tunicamycin-treated HepG2 cells.	Sesquiterpenes	24-38	heat shock protein family A (Hsp70) member 5	Homo sapiens	70-75
26253511-4	2015	The results revealed that GBA, as a biologically active sesquiterpene coumarin derivative, has an ability to bind strongly to MMP9.	Sesquiterpenes	56-69	matrix metallopeptidase 9	Homo sapiens	126-130
25940560-1	2015	Multiproduct terpene synthases TPS4-B73 and TPS5-Delprim from maize (Zea mays) catalyze the conversion of farnesyl diphosphate (FDP) and geranyl diphosphate (GDP) into a complex mixture of sesquiterpenes and monoterpenes, respectively.	Sesquiterpenes	189-203	terpene synthase 4	Zea mays	31-39
26303437-0	2015	The maize transcription factor EREB58 mediates the jasmonate-induced production of sesquiterpene volatiles.	Sesquiterpenes	83-96	uncharacterized LOC100384381	Zea mays	31-37
26303437-9	2015	Transgenic maize plants overexpressing EREB58 constitutively over-accumulate TPS10 transcript, and also (E)-beta-farnesene and (E)-alpha-bergamotene, two major sesquiterpenes produced by TPS10.	Sesquiterpenes	160-174	uncharacterized LOC100384381	Zea mays	39-45
26303437-11	2015	In sum, these results demonstrate that EREB58 is a positive regulator of sesquiterpene production by directly promoting TPS10 expression.	Sesquiterpenes	73-86	uncharacterized LOC100384381	Zea mays	39-45
26303437-11	2015	In sum, these results demonstrate that EREB58 is a positive regulator of sesquiterpene production by directly promoting TPS10 expression.	Sesquiterpenes	73-86	(E)-beta-farnesene synthase	Zea mays	120-125
26081757-0	2015	Sesquiterpenes with TRAIL-resistance overcoming activity from Xanthium strumarium.	Sesquiterpenes	0-14	TNF superfamily member 10	Homo sapiens	20-25
26081757-3	2015	In our screening program on natural resources targeting overcoming TRAIL-resistance, activity-guided fractionations of the extract of Xanthium strumarium led to the isolation of five sesquiterpene compounds (1-5).	Sesquiterpenes	183-196	TNF superfamily member 10	Homo sapiens	67-72
25940560-1	2015	Multiproduct terpene synthases TPS4-B73 and TPS5-Delprim from maize (Zea mays) catalyze the conversion of farnesyl diphosphate (FDP) and geranyl diphosphate (GDP) into a complex mixture of sesquiterpenes and monoterpenes, respectively.	Sesquiterpenes	189-203	Inactive sesquithujene synthase	Zea mays	44-48
25644034-0	2015	Molecular characterization of two isoforms of a farnesyl pyrophosphate synthase gene in wheat and their roles in sesquiterpene synthesis and inducible defence against aphid infestation.	Sesquiterpenes	113-126	farnesyl pyrophosphate synthase A1	Triticum aestivum	48-79
25843566-4	2015	A deeper insight into the structure-activity relationship of sesquiterpene coumarins revealed that ring-opened drimane-type sesquiterpene coumarins including farnesiferol B, farnesiferol C and lehmferin possessed the best inhibitory effects on P-gp pump efflux and they could be considered as lead scaffolds for further structure modifications.	Sesquiterpenes	61-74	phosphoglycolate phosphatase	Homo sapiens	244-248
25843566-4	2015	A deeper insight into the structure-activity relationship of sesquiterpene coumarins revealed that ring-opened drimane-type sesquiterpene coumarins including farnesiferol B, farnesiferol C and lehmferin possessed the best inhibitory effects on P-gp pump efflux and they could be considered as lead scaffolds for further structure modifications.	Sesquiterpenes	124-137	phosphoglycolate phosphatase	Homo sapiens	244-248
25680349-1	2015	MAIN CONCLUSION: Of the three functional FPPS identified in maize, fpps3 is induced by herbivory to produce FDP important for the formation of the volatile sesquiterpenes of plant defense.	Sesquiterpenes	156-170	farnesyl pyrophosphate synthase	Zea mays	41-45
25680349-4	2015	To elucidate the regulation of sesquiterpene biosynthesis in maize, we identified and characterized the farnesyl diphosphate synthase (FPPS) gene family which consists of three genes.	Sesquiterpenes	31-44	farnesyl pyrophosphate synthase	Zea mays	104-133
25680349-4	2015	To elucidate the regulation of sesquiterpene biosynthesis in maize, we identified and characterized the farnesyl diphosphate synthase (FPPS) gene family which consists of three genes.	Sesquiterpenes	31-44	farnesyl pyrophosphate synthase	Zea mays	135-139
25644034-2	2015	Herbivore-induced emission of sesquiterpenes can repel pests, and farnesyl pyrophosphate synthase (FPS) is a key enzyme involved in sesquiterpene biosynthesis.	Sesquiterpenes	30-44	farnesyl pyrophosphate synthase A1	Triticum aestivum	99-102
25644034-2	2015	Herbivore-induced emission of sesquiterpenes can repel pests, and farnesyl pyrophosphate synthase (FPS) is a key enzyme involved in sesquiterpene biosynthesis.	Sesquiterpenes	30-43	farnesyl pyrophosphate synthase A1	Triticum aestivum	66-97
25644034-2	2015	Herbivore-induced emission of sesquiterpenes can repel pests, and farnesyl pyrophosphate synthase (FPS) is a key enzyme involved in sesquiterpene biosynthesis.	Sesquiterpenes	30-43	farnesyl pyrophosphate synthase A1	Triticum aestivum	99-102
25644034-3	2015	However, fps orthologues in wheat and their functional roles in sesquiterpene synthesis and defence against aphid infestation are unknown.	Sesquiterpenes	64-77	farnesyl pyrophosphate synthase A1	Triticum aestivum	9-12
25229208-1	2014	The secondary organic aerosol (SOA) mass yields from NO3 oxidation of a series of biogenic volatile organic compounds (BVOCs), consisting of five monoterpenes and one sesquiterpene (alpha-pinene, beta-pinene, Delta-3-carene, limonene, sabinene, and beta-caryophyllene), were investigated in a series of continuous flow experiments in a 10 m(3) indoor Teflon chamber.	Sesquiterpenes	167-180	NBL1, DAN family BMP antagonist	Homo sapiens	53-56
25695368-0	2015	Restoration of Chemosensitivity in P-Glycoprotein-Dependent Multidrug-Resistant Cells by Dihydro-beta-agarofuran Sesquiterpenes from Celastrus vulcanicola.	Sesquiterpenes	113-127	ATP binding cassette subfamily B member 1	Homo sapiens	35-49
25658388-1	2015	Multiproduct terpene synthases TPS4-B73 and TPS5-Delprim from Zea mays exhibit isotopically sensitive branching in the formation of mono- and sesquiterpene volatiles.	Sesquiterpenes	142-155	terpene synthase 4	Zea mays	31-39
25658388-1	2015	Multiproduct terpene synthases TPS4-B73 and TPS5-Delprim from Zea mays exhibit isotopically sensitive branching in the formation of mono- and sesquiterpene volatiles.	Sesquiterpenes	142-155	Inactive sesquithujene synthase	Zea mays	44-48
25446581-6	2015	The guaiane sesquiterpene is lacking the methylene-gamma-lactone function that is typically involved in the inhibiting properties of sesquiterpenes on NF-kappaB, a pivotal transcription factor in inflammatory processes.	Sesquiterpenes	133-147	nuclear factor kappa B subunit 1	Homo sapiens	151-160
25525269-0	2015	Identification of significant amino acids in multiple transmembrane domains of human transient receptor potential ankyrin 1 (TRPA1) for activation by eudesmol, an oxygenized sesquiterpene in hop essential oil.	Sesquiterpenes	174-187	transient receptor potential cation channel subfamily A member 1	Homo sapiens	85-123
25525269-0	2015	Identification of significant amino acids in multiple transmembrane domains of human transient receptor potential ankyrin 1 (TRPA1) for activation by eudesmol, an oxygenized sesquiterpene in hop essential oil.	Sesquiterpenes	174-187	transient receptor potential cation channel subfamily A member 1	Homo sapiens	125-130
26133070-0	2015	Sesquiterpenes from the fruiting bodies of Ramaria formosa and their human neutrophil elastase inhibitory activity.	Sesquiterpenes	0-14	elastase, neutrophil expressed	Homo sapiens	75-94
25350537-1	2014	In a screening program of natural compounds from fungi, the known cyclopentanoid sesquiterpene (-)-cyclonerodiol was identified as a specific inhibitor of the IL-4 induced STAT6 signaling pathway (IC50 = 9.7 muM) which is required for the differentiation of naive CD4 T cells to T helper type 2 (Th2) lymphocytes.	Sesquiterpenes	81-94	interleukin 4	Homo sapiens	159-163
25350537-1	2014	In a screening program of natural compounds from fungi, the known cyclopentanoid sesquiterpene (-)-cyclonerodiol was identified as a specific inhibitor of the IL-4 induced STAT6 signaling pathway (IC50 = 9.7 muM) which is required for the differentiation of naive CD4 T cells to T helper type 2 (Th2) lymphocytes.	Sesquiterpenes	81-94	signal transducer and activator of transcription 6	Homo sapiens	172-177
25538111-3	2015	In Arabidopsis thaliana, FPS2, encoding cytosolic farnesyldiphosphate synthase, is implicated in the synthesis of cytosolic FDP, but it is not known whether enhanced levels of FDP have a commensurate effect on sesquiterpene-mediated defence responses.	Sesquiterpenes	210-223	farnesyl diphosphate synthase 2	Arabidopsis thaliana	25-29
25538111-11	2015	CONCLUSIONS: Over-expression of FPS2 in the cytosol and targeting of its translated product to chloroplasts in arabidopsis led to synthesis of several novel sesquiterpenes, including E-beta-farnesene, and induced alarm responses in M. persicae.	Sesquiterpenes	157-171	farnesyl diphosphate synthase 2	Arabidopsis thaliana	32-36
25446581-6	2015	The guaiane sesquiterpene is lacking the methylene-gamma-lactone function that is typically involved in the inhibiting properties of sesquiterpenes on NF-kappaB, a pivotal transcription factor in inflammatory processes.	Sesquiterpenes	12-25	nuclear factor kappa B subunit 1	Homo sapiens	151-160
24823713-4	2014	Moreover, a robust strategy for the introduction of the exo-methylene group at C-3, commonly found in many sesquiterpenes, was developed that makes use of masking the alkene in the alpha,beta-unsaturated carbonyl system by O-pivaoyl, which is stable under acidic and mild basic conditions but eliminated upon treatment with strong bases.	Sesquiterpenes	107-121	complement C3	Homo sapiens	79-82
25073705-4	2014	JA/JA-Ile deficiency in OPR3-RNAi plants resulted in reduced trichome formation and impaired monoterpene and sesquiterpene production.	Sesquiterpenes	109-122	12-oxophytodienoate reductase 3	Solanum lycopersicum	24-28
25009443-8	2014	In addition, representative syntheses are presented for the monoterpenes (C10), sesquiterpenes (C15), diterpenes (C20), triterpenes (C30) and tetraterpenes (C40).	Sesquiterpenes	80-94	placenta associated 8	Homo sapiens	96-99
24786692-4	2014	The present in silico study allows us to make important observations about the molecular details of the binding modes of a set of antileishmanial sesquiterpenes against four drug-enzyme targets [pteridine reductase-1 (PTR1), N-myristoyl transferase (NMT), cysteine synthase (CS), trypanothione synthetase (TryS)].	Sesquiterpenes	146-160	N-myristoyltransferase 1	Homo sapiens	225-248
24786692-4	2014	The present in silico study allows us to make important observations about the molecular details of the binding modes of a set of antileishmanial sesquiterpenes against four drug-enzyme targets [pteridine reductase-1 (PTR1), N-myristoyl transferase (NMT), cysteine synthase (CS), trypanothione synthetase (TryS)].	Sesquiterpenes	146-160	N-myristoyltransferase 1	Homo sapiens	250-253
25171128-7	2014	CONCLUSION: These results demonstrate that the anti-inflammatory effect of the sesquiterpene beta-caryophyllene involves CB2 receptor activation and the PPARgamma pathway and suggest beta-caryophyllene as an attractive molecule for the development of new drugs with therapeutic potential for the treatment of AD.	Sesquiterpenes	79-92	cannabinoid receptor 2 (macrophage)	Mus musculus	121-124
24486434-0	2014	Sesquiterpene dimmer (DSF-27) inhibits the release of neuroinflammatory mediators from microglia by targeting spleen tyrosine kinase (Syk) and Janus kinase 2 (Jak2): Two major non-receptor tyrosine signaling proteins involved in inflammatory events.	Sesquiterpenes	0-13	spleen tyrosine kinase	Mus musculus	134-137
24486434-0	2014	Sesquiterpene dimmer (DSF-27) inhibits the release of neuroinflammatory mediators from microglia by targeting spleen tyrosine kinase (Syk) and Janus kinase 2 (Jak2): Two major non-receptor tyrosine signaling proteins involved in inflammatory events.	Sesquiterpenes	0-13	Janus kinase 2	Mus musculus	143-157
24486434-0	2014	Sesquiterpene dimmer (DSF-27) inhibits the release of neuroinflammatory mediators from microglia by targeting spleen tyrosine kinase (Syk) and Janus kinase 2 (Jak2): Two major non-receptor tyrosine signaling proteins involved in inflammatory events.	Sesquiterpenes	0-13	Janus kinase 2	Mus musculus	159-163
24486434-3	2014	A main aim of the present study is to elucidate the contribution of two major NRPTKs (Syk and Jak2) in neuroinflammation suppression by a bioactive sesquiterpene dimmer (DSF-27).	Sesquiterpenes	148-161	spleen tyrosine kinase	Mus musculus	86-89
24486434-3	2014	A main aim of the present study is to elucidate the contribution of two major NRPTKs (Syk and Jak2) in neuroinflammation suppression by a bioactive sesquiterpene dimmer (DSF-27).	Sesquiterpenes	148-161	Janus kinase 2	Mus musculus	94-98
24486434-9	2014	Taken together, our findings indicate NRPTK signaling pathways including Syk/NF-kappaB and Jak2/Stat3 cascades are potential anti-neuroinflammatory targets in microglia, and may also set the basis for the use of sesquiterpene dimmer as a therapeutic approach for neuroinflammation via interruption of these pathways.	Sesquiterpenes	212-225	spleen tyrosine kinase	Mus musculus	73-76
24486434-9	2014	Taken together, our findings indicate NRPTK signaling pathways including Syk/NF-kappaB and Jak2/Stat3 cascades are potential anti-neuroinflammatory targets in microglia, and may also set the basis for the use of sesquiterpene dimmer as a therapeutic approach for neuroinflammation via interruption of these pathways.	Sesquiterpenes	212-225	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	77-86
24486434-9	2014	Taken together, our findings indicate NRPTK signaling pathways including Syk/NF-kappaB and Jak2/Stat3 cascades are potential anti-neuroinflammatory targets in microglia, and may also set the basis for the use of sesquiterpene dimmer as a therapeutic approach for neuroinflammation via interruption of these pathways.	Sesquiterpenes	212-225	Janus kinase 2	Mus musculus	91-95
24486434-9	2014	Taken together, our findings indicate NRPTK signaling pathways including Syk/NF-kappaB and Jak2/Stat3 cascades are potential anti-neuroinflammatory targets in microglia, and may also set the basis for the use of sesquiterpene dimmer as a therapeutic approach for neuroinflammation via interruption of these pathways.	Sesquiterpenes	212-225	signal transducer and activator of transcription 3	Mus musculus	96-101
24254315-6	2014	In this study, comparative sequence analysis of NDPS1 and zFPS enzymes from S. habrochaites accessions that synthesize either monoterpenes or sesquiterpenes was performed to identify amino acid residues that correlate with the ability to synthesize NPP or Z,Z-FPP.	Sesquiterpenes	142-156	dimethylallylcistransferase CPT1, chloroplastic	Solanum lycopersicum	48-53
25171128-7	2014	CONCLUSION: These results demonstrate that the anti-inflammatory effect of the sesquiterpene beta-caryophyllene involves CB2 receptor activation and the PPARgamma pathway and suggest beta-caryophyllene as an attractive molecule for the development of new drugs with therapeutic potential for the treatment of AD.	Sesquiterpenes	79-92	peroxisome proliferator activated receptor gamma	Mus musculus	153-162
24120505-0	2013	Sesquiterpene action, and morphogenetic signaling through the ortholog of retinoid X receptor, in higher Diptera.	Sesquiterpenes	0-13	retinoid X receptor alpha	Homo sapiens	74-93
24074555-6	2013	By in vitro assays of the recombinant proteins, it was found that GhTPS1 and GhTPS2 are sesquiterpene synthases: the former converted farnesyl pyrophosphate (FPP) into beta-caryophyllene and alpha-humulene in a ratio of 2:1, whereas the latter produced several sesquiterpenes with guaia-1(10),11-diene as the major product.	Sesquiterpenes	261-275	(-)-germacrene D synthase-like	Gossypium hirsutum	66-72
24074555-6	2013	By in vitro assays of the recombinant proteins, it was found that GhTPS1 and GhTPS2 are sesquiterpene synthases: the former converted farnesyl pyrophosphate (FPP) into beta-caryophyllene and alpha-humulene in a ratio of 2:1, whereas the latter produced several sesquiterpenes with guaia-1(10),11-diene as the major product.	Sesquiterpenes	261-275	terpene synthase 10-like	Gossypium hirsutum	77-83
23731014-0	2013	Inducers of hypoxic response: marine sesquiterpene quinones activate HIF-1.	Sesquiterpenes	37-50	hypoxia inducible factor 1 subunit alpha	Homo sapiens	69-74
23850985-0	2013	Interactions of sesquiterpenes zederone and germacrone with the human cytochrome P450 system.	Sesquiterpenes	16-30	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	70-85
23850985-1	2013	Misclassification of Curcuma species (family Zingiberaceae) may lead to unwanted human exposure to Curcuma elata sesquiterpenes zederone and germacrone which have caused hepatotoxicity and changes in CYP expression in laboratory animals.	Sesquiterpenes	113-127	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	200-203
23850985-3	2013	We found that both sesquiterpenes (1-30 muM) greatly induced expression of CYP2B6 and CYP3A4 but not CYP1A2 mRNAs in human primary hepatocytes (HPHs).	Sesquiterpenes	19-33	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	75-81
23850985-3	2013	We found that both sesquiterpenes (1-30 muM) greatly induced expression of CYP2B6 and CYP3A4 but not CYP1A2 mRNAs in human primary hepatocytes (HPHs).	Sesquiterpenes	19-33	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	86-92
23837557-3	2013	Keeping in view this point we evaluated sesquiterpenes of medicinal plant Amberboa ramosa for their cholinesterase inhibitory activity.	Sesquiterpenes	40-54	butyrylcholinesterase	Homo sapiens	100-114
23354070-3	2013	We describe here the isolation and biochemical characterization of the marine natural sesquiterpene palinurin as a GSK-3beta inhibitor.	Sesquiterpenes	86-99	glycogen synthase kinase 3 beta	Homo sapiens	115-124
23363415-2	2013	The volatile blend is dominated by sesquiterpenes of which the majority is produced by two herbivore-induced terpene synthases, TPS10 and TPS23.	Sesquiterpenes	35-49	(E)-beta-farnesene synthase	Zea mays	128-133
23363415-2	2013	The volatile blend is dominated by sesquiterpenes of which the majority is produced by two herbivore-induced terpene synthases, TPS10 and TPS23.	Sesquiterpenes	35-49	(E)-beta-caryophyllene synthase	Zea mays	138-143
23727776-3	2013	The sesquiterpene coumarin derivatives inhibited nitric oxide (NO) and inducible NO synthase (iNOS), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) gene expression in a murine macrophage-like cell line (RAW264.7), which was activated by lipopolysaccharide (LPS) and recombinant mouse interferon-gamma (IFN-gamma).	Sesquiterpenes	4-17	nitric oxide synthase 2, inducible	Mus musculus	71-92
23727776-3	2013	The sesquiterpene coumarin derivatives inhibited nitric oxide (NO) and inducible NO synthase (iNOS), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) gene expression in a murine macrophage-like cell line (RAW264.7), which was activated by lipopolysaccharide (LPS) and recombinant mouse interferon-gamma (IFN-gamma).	Sesquiterpenes	4-17	nitric oxide synthase 2, inducible	Mus musculus	94-98
23727776-3	2013	The sesquiterpene coumarin derivatives inhibited nitric oxide (NO) and inducible NO synthase (iNOS), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) gene expression in a murine macrophage-like cell line (RAW264.7), which was activated by lipopolysaccharide (LPS) and recombinant mouse interferon-gamma (IFN-gamma).	Sesquiterpenes	4-17	interleukin 6	Mus musculus	101-114
23727776-3	2013	The sesquiterpene coumarin derivatives inhibited nitric oxide (NO) and inducible NO synthase (iNOS), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) gene expression in a murine macrophage-like cell line (RAW264.7), which was activated by lipopolysaccharide (LPS) and recombinant mouse interferon-gamma (IFN-gamma).	Sesquiterpenes	4-17	interleukin 6	Mus musculus	116-120
23727776-3	2013	The sesquiterpene coumarin derivatives inhibited nitric oxide (NO) and inducible NO synthase (iNOS), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) gene expression in a murine macrophage-like cell line (RAW264.7), which was activated by lipopolysaccharide (LPS) and recombinant mouse interferon-gamma (IFN-gamma).	Sesquiterpenes	4-17	tumor necrosis factor	Mus musculus	127-154
23727776-3	2013	The sesquiterpene coumarin derivatives inhibited nitric oxide (NO) and inducible NO synthase (iNOS), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) gene expression in a murine macrophage-like cell line (RAW264.7), which was activated by lipopolysaccharide (LPS) and recombinant mouse interferon-gamma (IFN-gamma).	Sesquiterpenes	4-17	tumor necrosis factor	Mus musculus	156-165
23727776-3	2013	The sesquiterpene coumarin derivatives inhibited nitric oxide (NO) and inducible NO synthase (iNOS), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) gene expression in a murine macrophage-like cell line (RAW264.7), which was activated by lipopolysaccharide (LPS) and recombinant mouse interferon-gamma (IFN-gamma).	Sesquiterpenes	4-17	interferon gamma	Mus musculus	303-319
23727776-3	2013	The sesquiterpene coumarin derivatives inhibited nitric oxide (NO) and inducible NO synthase (iNOS), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) gene expression in a murine macrophage-like cell line (RAW264.7), which was activated by lipopolysaccharide (LPS) and recombinant mouse interferon-gamma (IFN-gamma).	Sesquiterpenes	4-17	interferon gamma	Mus musculus	321-330
22330799-3	2012	Optimal sesquiterpene production was obtained by modulating the expression of one of the key metabolic steps of the mevalonate (MVA) pathway, squalene synthase (Erg9).	Sesquiterpenes	8-21	bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase	Saccharomyces cerevisiae S288C	161-165
23259547-0	2012	Positive genetic interactors of HMG2 identify a new set of genetic perturbations for improving sesquiterpene production in Saccharomyces cerevisiae.	Sesquiterpenes	95-108	hydroxymethylglutaryl-CoA reductase (NADPH) HMG2	Saccharomyces cerevisiae S288C	32-36
23259547-3	2012	RESULTS: Aiming to identify new gene targets which can be manipulated to increase sesquiterpene production, a set of HMG2 positive genetic interactors were assessed as single and digenic heterozygous deletions in the presence or absence of stable HMG2(K6R) overexpression.	Sesquiterpenes	82-95	hydroxymethylglutaryl-CoA reductase (NADPH) HMG2	Saccharomyces cerevisiae S288C	117-121
23021236-3	2012	This study aims to investigate the hepatoprotective effects of a sesquiterpene-rich fraction (SRF) from the aerial part of C. glandulosum on carbon tetrachloride (CCl4)-induced acute hepatotoxicity in mice, and on priming with Bacillus Calmette-Guerin (BCG) followed by lipopolysaccharide (LPS)-induced immunological liver injury in mice.	Sesquiterpenes	65-78	chemokine (C-C motif) ligand 4	Mus musculus	163-167
22396212-3	2012	In this study, we determined the role of sesquiterpene or diterpene isoprenoids on the regulation of Rho G-protein expression, activation, and stability in human trabecular meshwork (TM) cells.	Sesquiterpenes	41-54	ras homolog family member G	Homo sapiens	101-106
22459969-7	2012	Both RcSeTPS5 and RcSeTPS10 produced multiple sesquiterpenes.	Sesquiterpenes	46-60	terpene synthase 5	Ricinus communis	5-13
22459969-7	2012	Both RcSeTPS5 and RcSeTPS10 produced multiple sesquiterpenes.	Sesquiterpenes	46-60	terpene synthase 10	Ricinus communis	18-27
22669881-4	2012	The induction of TPS21 and TPS11 results in increased emission of sesquiterpene, especially (E)-beta-caryophyllene.	Sesquiterpenes	66-79	terpene synthase 21	Arabidopsis thaliana	17-22
22669881-4	2012	The induction of TPS21 and TPS11 results in increased emission of sesquiterpene, especially (E)-beta-caryophyllene.	Sesquiterpenes	66-79	trehalose phosphatase/synthase 11	Arabidopsis thaliana	27-32
22669881-5	2012	DELLAs, the GA signaling repressors, negatively affect sesquiterpene biosynthesis, as the sesquiterpene synthase genes were repressed in plants overaccumulating REPRESSOR OF GA1-3 (RGA), one of the Arabidopsis DELLAs, and upregulated in a penta DELLA-deficient mutant.	Sesquiterpenes	55-68	GRAS family transcription factor family protein	Arabidopsis thaliana	161-179
22669881-5	2012	DELLAs, the GA signaling repressors, negatively affect sesquiterpene biosynthesis, as the sesquiterpene synthase genes were repressed in plants overaccumulating REPRESSOR OF GA1-3 (RGA), one of the Arabidopsis DELLAs, and upregulated in a penta DELLA-deficient mutant.	Sesquiterpenes	55-68	GRAS family transcription factor family protein	Arabidopsis thaliana	181-184
22830335-7	2012	These identified natural MDM2 inhibitors include a plethora of diverse chemical frameworks, ranging from flavonoids, steroids, and sesquiterpenes to alkaloids.	Sesquiterpenes	131-145	MDM2 proto-oncogene	Homo sapiens	25-29
22493800-4	2012	This review is focused on the natural compounds that exhibit the aromatase inhibition, which include flavonoids, xanthones, coumarins, and sesquiterpenes.	Sesquiterpenes	139-153	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	65-74
21856049-0	2011	Overcoming human P-glycoprotein-dependent multidrug resistance with novel dihydro-beta-agarofuran sesquiterpenes.	Sesquiterpenes	98-112	ATP binding cassette subfamily B member 1	Homo sapiens	17-31
21843620-7	2011	Among 12 compounds isolated from ECR, mostly sesquiterpenes induced stronger HO-1 expression than monoterpenes in macrophage cells.	Sesquiterpenes	45-59	heme oxygenase 1	Mus musculus	77-81
21843620-8	2011	Nootkatone and valencene (sesquiterpenes) significantly inhibited iNOS expression and NO production in LPS-simulated RAW264.7 cells.	Sesquiterpenes	26-40	nitric oxide synthase 2, inducible	Mus musculus	66-70
21843620-11	2011	CONCLUSIONS: Taken together, we concluded that possible anti-inflammatory mechanism of ECR is, at least, due to HO-1 induction, in which sesquiterpenes such as nootkatone and valencene play a crucial role.	Sesquiterpenes	137-151	heme oxygenase 1	Mus musculus	112-116
21367956-9	2011	Taken together, these findings suggest that upregulation of HO-1 expression by zerumbone is mediated through activation of Nrf2 signaling, which provides a mechanistic basis for the chemopreventive effects of this sesquiterpene on mouse skin carcinogenesis.	Sesquiterpenes	214-227	heme oxygenase 1	Mus musculus	60-64
21287405-8	2011	may cause food-drug interactions via cytochrome P450 inhibition by sesquiterpene 7 and curcuminoids 11 and 12.	Sesquiterpenes	67-80	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	48-52
21515265-2	2011	A TPS-b sesquiterpene synthase from apple (MdAFS1), which predominantly produces alpha-farnesene, can also synthesize the monoterpene (E)-beta-ocimene.	Sesquiterpenes	8-21	(E,E)-alpha-farnesene synthase	Malus domestica	43-49
21515265-3	2011	The dual activity offered a functional link to an ancestral MdAFS1 enzyme and a rational basis for investigation of the evolution of TPS-b sesquiterpene enzymes.	Sesquiterpenes	139-152	(E,E)-alpha-farnesene synthase	Malus domestica	60-66
21515265-4	2011	Protein modelling and mutagenesis analysis of the MdAFS1 active site identified a non-synonymous nucleotide substitution that could account for the requisite shift in substrate specificity necessary for the emergence of its sesquiterpene activity during the evolution of the TPS-b enzymes.	Sesquiterpenes	224-237	(E,E)-alpha-farnesene synthase	Malus domestica	50-56
21367956-9	2011	Taken together, these findings suggest that upregulation of HO-1 expression by zerumbone is mediated through activation of Nrf2 signaling, which provides a mechanistic basis for the chemopreventive effects of this sesquiterpene on mouse skin carcinogenesis.	Sesquiterpenes	214-227	nuclear factor, erythroid derived 2, like 2	Mus musculus	123-127
20713377-6	2011	Western blot analysis indicated that 2 of the compounds, AT-I and AT-II, could inactivate ERK, where all 3 inhibited AKT activation, suggesting that Ras/ERK and PI3K/AKT signaling pathways are involved in the action mechanisms of the LAR sesquiterpene compounds.	Sesquiterpenes	238-251	mitogen-activated protein kinase 1	Mus musculus	90-93
21607717-6	2011	A mixture of both the TPS8 and TPS10 volatile blends, however, was more effective in parasitoid attraction, indicating that constitutively released sesquiterpenes enhance the attraction of those induced by herbivores.	Sesquiterpenes	148-162	Alpha-copaene synthase	Zea mays	22-26
21607717-6	2011	A mixture of both the TPS8 and TPS10 volatile blends, however, was more effective in parasitoid attraction, indicating that constitutively released sesquiterpenes enhance the attraction of those induced by herbivores.	Sesquiterpenes	148-162	(E)-beta-farnesene synthase	Zea mays	31-36
21544718-0	2011	Isolation of megastigmane sesquiterpenes from the silkworm (Bombyx mori L.) droppings and their promotion activity on HO-1 and SIRT1.	Sesquiterpenes	26-40	sirtuin 1	Homo sapiens	127-132
20713377-6	2011	Western blot analysis indicated that 2 of the compounds, AT-I and AT-II, could inactivate ERK, where all 3 inhibited AKT activation, suggesting that Ras/ERK and PI3K/AKT signaling pathways are involved in the action mechanisms of the LAR sesquiterpene compounds.	Sesquiterpenes	238-251	mitogen-activated protein kinase 1	Mus musculus	153-156
20713377-6	2011	Western blot analysis indicated that 2 of the compounds, AT-I and AT-II, could inactivate ERK, where all 3 inhibited AKT activation, suggesting that Ras/ERK and PI3K/AKT signaling pathways are involved in the action mechanisms of the LAR sesquiterpene compounds.	Sesquiterpenes	238-251	thymoma viral proto-oncogene 1	Mus musculus	166-169
20591838-6	2010	SlDXS2 down-regulation led to a decrease in the monoterpene beta-phellandrene and an increase in two sesquiterpenes in trichomes.	Sesquiterpenes	101-115	1-deoxy-D-xylulose 5-phosphate synthase 2	Solanum lycopersicum	0-6
21031633-2	2011	Many biological features of this genus such as cytotoxicity, antibacterial, antiviral, P-glycoprotein (P-gp) inhibitory and antiinflammatory activity have been attributed to sesquiterpene coumarins; structures containing a common coumarin group and a sesquiterpene moiety.	Sesquiterpenes	174-187	ATP binding cassette subfamily B member 1	Homo sapiens	87-101
21031633-2	2011	Many biological features of this genus such as cytotoxicity, antibacterial, antiviral, P-glycoprotein (P-gp) inhibitory and antiinflammatory activity have been attributed to sesquiterpene coumarins; structures containing a common coumarin group and a sesquiterpene moiety.	Sesquiterpenes	174-187	ATP binding cassette subfamily B member 1	Homo sapiens	103-107
21380805-2	2011	In rat basophilic leukemia (RBL)-1 cells, the sesquiterpenes strongly inhibited 5-lipoxygenase-catalyzed leukotrienes production.	Sesquiterpenes	46-60	arachidonate 5-lipoxygenase	Rattus norvegicus	80-94
21380805-5	2011	It was also found that the most active sesquiterpene (valencene) and CRE inhibited beta-hexosaminidase degranulation by inhibiting the initial activation reaction, Lyn phosphorylation, in IgE-stimulated RBL-2H3 cells.	Sesquiterpenes	39-52	O-GlcNAcase	Rattus norvegicus	83-102
21380805-5	2011	It was also found that the most active sesquiterpene (valencene) and CRE inhibited beta-hexosaminidase degranulation by inhibiting the initial activation reaction, Lyn phosphorylation, in IgE-stimulated RBL-2H3 cells.	Sesquiterpenes	39-52	LYN proto-oncogene, Src family tyrosine kinase	Rattus norvegicus	164-167
21276210-5	2011	The approach was applied on the yeast sterol biosynthetic pathway genes HMG2, ERG20 and IDI1 resulting in several-fold increase in plant monoterpene and sesquiterpene production.	Sesquiterpenes	153-166	hydroxymethylglutaryl-CoA reductase (NADPH) HMG2	Saccharomyces cerevisiae S288C	72-76
21276210-5	2011	The approach was applied on the yeast sterol biosynthetic pathway genes HMG2, ERG20 and IDI1 resulting in several-fold increase in plant monoterpene and sesquiterpene production.	Sesquiterpenes	153-166	bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase	Saccharomyces cerevisiae S288C	78-83
21276210-5	2011	The approach was applied on the yeast sterol biosynthetic pathway genes HMG2, ERG20 and IDI1 resulting in several-fold increase in plant monoterpene and sesquiterpene production.	Sesquiterpenes	153-166	isopentenyl-diphosphate delta-isomerase IDI1	Saccharomyces cerevisiae S288C	88-92
20932829-2	2011	In vitro experiments included the histological study of larval damage and in vivo studies the measurement of myeloperoxidase activity in rat gastrointestinal tract after administration of the sesquiterpenes.	Sesquiterpenes	192-206	myeloperoxidase	Rattus norvegicus	109-124
20465285-2	2010	The significance of the Rh-catalyzed [(3 + 2) + 1] cycloaddition has been demonstrated by the total synthesis of a furanoid sesquiterpene natural product, alpha-agarofuran, in which the bicyclic skeleton was constructed by the [(3 + 2) + 1] reaction of 1-yne-VCP and CO.	Sesquiterpenes	124-137	valosin containing protein	Homo sapiens	259-262
19775115-1	2009	Isoacanthodoral (1) is a structurally unique sesquiterpene in that it is a bicyclo[4.4.0]dec-1-ene with a cis- rather than the common trans-junction between the constituting rings.	Sesquiterpenes	45-58	deleted in esophageal cancer 1	Homo sapiens	89-94
20091767-2	2010	Over-expression of the catalytic domain of HMG1, both from the genome and plasmid, resulted in higher production of cubebol, a plant originating sesquiterpene, and increased squalene accumulation.	Sesquiterpenes	145-158	hydroxymethylglutaryl-CoA reductase (NADPH) HMG1	Saccharomyces cerevisiae S288C	43-47
20329739-3	2010	All isolated sesquiterpenes were assayed for cytotoxicity against two tyrosine kinase inhibitor-resistant cell lines, K562R and DA1-3b/M2(BCR-ABL).	Sesquiterpenes	13-27	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	138-145
20024113-0	2009	Novel dihydro-beta-agarofuran sesquiterpenes as potent modulators of human P-glycoprotein dependent multidrug resistance.	Sesquiterpenes	30-44	ATP binding cassette subfamily B member 1	Homo sapiens	75-89
19619667-3	2009	Deletion of NADPH-dependent glutamate dehydrogenase encoded by GDH1 was identified as the best target gene for the improvement of sesquiterpene biosynthesis in yeast.	Sesquiterpenes	130-143	glutamate dehydrogenase (NADP(+)) GDH1	Saccharomyces cerevisiae S288C	63-67
18550530-0	2008	TRPA1 mediates the noxious effects of natural sesquiterpene deterrents.	Sesquiterpenes	46-59	transient receptor potential cation channel subfamily A member 1	Homo sapiens	0-5
19336945-0	2009	Sesquiterpenes from cultures of the basidiomycete Clitocybe conglobata and their 11 beta-hydroxysteroid dehydrogenase inhibitory activity.	Sesquiterpenes	0-14	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	81-88
19359488-8	2009	Valencene synthase (VvValCS) enzyme activity, which produces the major sesquiterpene volatiles of grapevine flowers, is present in anthers.	Sesquiterpenes	71-84	valencene synthase	Vitis vinifera	20-27
19269833-4	2009	In in vitro assays, three sesquiterpene-like carotenoid cleavage dioxygenase (SLCCD) inhibitor compounds 13, 17 and 18 were found to act as inhibitors of Arabidopsis thaliana NCED 3 (AtNCED3) with K(i)"s of 93, 57 and 87 microM, respectively.	Sesquiterpenes	26-39	nine-cis-epoxycarotenoid dioxygenase 3	Arabidopsis thaliana	183-190
18550530-5	2008	Here we show that isovelleral, a noxious fungal sesquiterpene, excites sensory neurons through activation of TPRA1, an ion channel involved in inflammatory pain signaling.	Sesquiterpenes	48-61	transmembrane protein adipocyte associated 1	Homo sapiens	109-114
18550530-6	2008	TRPA1 is also activated by polygodial, a drimane sesquiterpene synthesized by plants and animals.	Sesquiterpenes	49-62	transient receptor potential cation channel subfamily A member 1	Homo sapiens	0-5
18550530-7	2008	TRPA1-deficient mice show greatly reduced nocifensive behavior in response to isovelleral, indicating that TRPA1 is the major receptor for deterrent sesquiterpenes in vivo.	Sesquiterpenes	149-163	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	0-5
18550530-7	2008	TRPA1-deficient mice show greatly reduced nocifensive behavior in response to isovelleral, indicating that TRPA1 is the major receptor for deterrent sesquiterpenes in vivo.	Sesquiterpenes	149-163	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	107-112
17149609-3	2007	The aim of this study was to investigate the effects of sesquiterpenes isolated from Asteraceae, namely melampolides (enhydrin, tetraludin A) and repandolides (repandins A, B, D and E) on the activation of NF-kappaB, cell growth of cancer cells, cell cycle progression and apoptosis.	Sesquiterpenes	56-70	nuclear factor kappa B subunit 1	Homo sapiens	206-215
17705244-4	2008	In order to enhance the availability of the precursor for synthesis of sesquiterpenes, farnesyl diphosphate (FPP), the ERG9 gene which is responsible for conversion of FPP to squalene was downregulated by replacing the native ERG9 promoter with the regulatable MET3 promoter combined with addition of 2 mM methionine to the medium.	Sesquiterpenes	71-85	bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase	Saccharomyces cerevisiae S288C	119-123
17705244-4	2008	In order to enhance the availability of the precursor for synthesis of sesquiterpenes, farnesyl diphosphate (FPP), the ERG9 gene which is responsible for conversion of FPP to squalene was downregulated by replacing the native ERG9 promoter with the regulatable MET3 promoter combined with addition of 2 mM methionine to the medium.	Sesquiterpenes	71-85	bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase	Saccharomyces cerevisiae S288C	226-230
17850057-0	2007	Biological evaluation, structure-activity relationships, and three-dimensional quantitative structure-activity relationship studies of dihydro-beta-agarofuran sesquiterpenes as modulators of P-glycoprotein-dependent multidrug resistance.	Sesquiterpenes	159-173	ATP binding cassette subfamily B member 1	Homo sapiens	191-205
17850057-2	2007	Here, we report the inhibitory activity of a series of 76 dihydro-beta-agarofuran sesquiterpenes, tested on NIH-3T3 cells expressing the human P-glycoprotein (Pgp) multidrug transporter, to establish quantitative comparisons of their respective abilities to block the drug transport activity.	Sesquiterpenes	82-96	ATP binding cassette subfamily B member 1	Homo sapiens	143-157
18524777-3	2008	Two maize genes were isolated that encode very similar sesquiterpene synthases, TPS6 and TPS11, which both produce beta-bisabolene, a common monocyclic sesquiterpene, and beta-macrocarpene, an uncommon bicyclic olefin.	Sesquiterpenes	55-68	(S)-beta-macrocarpene synthase	Zea mays	80-84
18524777-3	2008	Two maize genes were isolated that encode very similar sesquiterpene synthases, TPS6 and TPS11, which both produce beta-bisabolene, a common monocyclic sesquiterpene, and beta-macrocarpene, an uncommon bicyclic olefin.	Sesquiterpenes	55-68	(S)-beta-macrocarpene synthase	Zea mays	89-94
17850057-2	2007	Here, we report the inhibitory activity of a series of 76 dihydro-beta-agarofuran sesquiterpenes, tested on NIH-3T3 cells expressing the human P-glycoprotein (Pgp) multidrug transporter, to establish quantitative comparisons of their respective abilities to block the drug transport activity.	Sesquiterpenes	82-96	ATP binding cassette subfamily B member 1	Homo sapiens	159-162
17850057-3	2007	The screening was performed on the basis of the ability of sesquiterpenes to modulate the intracellular accumulation of the classical Pgp substrate daunorubicin.	Sesquiterpenes	59-73	ATP binding cassette subfamily B member 1	Homo sapiens	134-137
17850057-5	2007	The most salient features of these requirements are in the region of the substituents at the C-2, C-3, and C-8 positions, which seem to be critical for determining the overall effectiveness of sesquiterpenes as Pgp inhibitors.	Sesquiterpenes	193-207	complement C2	Homo sapiens	93-101
17850057-5	2007	The most salient features of these requirements are in the region of the substituents at the C-2, C-3, and C-8 positions, which seem to be critical for determining the overall effectiveness of sesquiterpenes as Pgp inhibitors.	Sesquiterpenes	193-207	ATP binding cassette subfamily B member 1	Homo sapiens	211-214
17031030-5	2006	The sesquiterpene, polygodial, also exhibited strong inhibitory activity against human platelet aggregation and 5-LOX.	Sesquiterpenes	4-17	lysyl oxidase	Homo sapiens	114-117
16455045-0	2006	Insights into the molecular mechanism of action of Celastraceae sesquiterpenes as specific, non-transported inhibitors of human P-glycoprotein.	Sesquiterpenes	64-78	ATP binding cassette subfamily B member 1	Homo sapiens	128-142
16739070-11	2006	To our knowledge, this is the first report identifying sesquiterpene coumarins from Ferula as possible drug candidates for the reversion of MDR encoded by the MDR1 gene or the synthesis of agents probing Pgp.	Sesquiterpenes	55-68	ATP binding cassette subfamily B member 1	Canis lupus familiaris	159-163
16739070-11	2006	To our knowledge, this is the first report identifying sesquiterpene coumarins from Ferula as possible drug candidates for the reversion of MDR encoded by the MDR1 gene or the synthesis of agents probing Pgp.	Sesquiterpenes	55-68	PGP	Canis lupus familiaris	204-207
16464597-3	2006	The new compound was determined to be a spirovetivane-type sesquiterpene, (4R,5R,7R)-1(10)-spirovetiven-11-ol-2-one, by spectroscopic data and showed induction effect of BDNF mRNA.	Sesquiterpenes	59-72	brain-derived neurotrophic factor	Rattus norvegicus	170-174
16297849-2	2006	The maize sesquiterpene synthase TPS4, for example, produces a mixture of 14 different olefinic sesquiterpenes.	Sesquiterpenes	96-110	terpene synthase 4	Zea mays	33-37
16418295-6	2006	Overexpression of tps10 in Arabidopsis thaliana resulted in plants emitting high quantities of TPS10 sesquiterpene products identical to those released by maize.	Sesquiterpenes	101-114	terpene synthase 10	Arabidopsis thaliana	18-23
16418295-6	2006	Overexpression of tps10 in Arabidopsis thaliana resulted in plants emitting high quantities of TPS10 sesquiterpene products identical to those released by maize.	Sesquiterpenes	101-114	terpene synthase 10	Arabidopsis thaliana	95-100
16418295-7	2006	Using these transgenic Arabidopsis plants as odor sources in olfactometer assays showed that females of the parasitoid Cotesia marginiventris learn to exploit the TPS10 sesquiterpenes to locate their lepidopteran hosts after prior exposure to these volatiles in association with hosts.	Sesquiterpenes	169-183	(E)-beta-farnesene synthase	Zea mays	163-168
16464597-0	2006	New sesquiterpene from Vietnamese agarwood and its induction effect on brain-derived neurotrophic factor mRNA expression in vitro.	Sesquiterpenes	4-17	brain-derived neurotrophic factor	Rattus norvegicus	71-104
16457780-1	2006	This study was designed to assess the participation of transient receptor potential vanilloid 1 (TRPV1) in the biological effects induced by the plant-derived sesquiterpenes polygodial and drimanial.	Sesquiterpenes	159-173	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	55-95
16457780-1	2006	This study was designed to assess the participation of transient receptor potential vanilloid 1 (TRPV1) in the biological effects induced by the plant-derived sesquiterpenes polygodial and drimanial.	Sesquiterpenes	159-173	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	97-102
16457780-7	2006	Together, the present results strongly suggest that the pharmacological actions of plant-derived sesquiterpenes polygodial and drimanial, seem to be partially mediated by activation of TRPV1.	Sesquiterpenes	97-111	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	185-190
16455045-1	2006	Dihydro-beta-agarofuran sesquiterpenes from Celastraceae have been recently shown to bind to human P-glycoprotein (Pgp), functioning as specific, mixed-type inhibitors of its drug transport activity, as well as multidrug resistance (MDR) modulators in vitro.	Sesquiterpenes	24-38	ATP binding cassette subfamily B member 1	Homo sapiens	99-113
16455045-1	2006	Dihydro-beta-agarofuran sesquiterpenes from Celastraceae have been recently shown to bind to human P-glycoprotein (Pgp), functioning as specific, mixed-type inhibitors of its drug transport activity, as well as multidrug resistance (MDR) modulators in vitro.	Sesquiterpenes	24-38	ATP binding cassette subfamily B member 1	Homo sapiens	115-118
16455045-3	2006	We performed transport experiments with a newly synthesized fluorescent sesquiterpene derivative, which retains the anti-Pgp activity of its natural precursor.	Sesquiterpenes	72-85	ATP binding cassette subfamily B member 1	Homo sapiens	121-124
15467238-3	2004	The 80% aqueous methanol extract of the roots of Ferula fukanensis (FFE) and the sesquiterpene coumarin derivatives inhibited nitric oxide (NO) production and inducible NO synthase (iNOS) gene expression by a murine macrophage-like cell line (RAW 264.7), which was activated by lipopolysaccharide (LPS) and recombinant mouse interferon-gamma (IFN-gamma).	Sesquiterpenes	81-94	interferon gamma	Mus musculus	325-341
15974580-0	2005	Reversion of human Pgp-dependent multidrug resistance by new sesquiterpenes from Zinowiewia costaricensis.	Sesquiterpenes	61-75	phosphoglycolate phosphatase	Homo sapiens	19-22
15827605-1	2005	Farnesyl diphosphate synthase (FPPS) is a key enzyme in isoprenoid biosynthesis which supplies sesquiterpene precursors for several classes of essential metabolites including sterols, dolichols, ubiquinones and carotenoids as well as substrates for farnesylation and geranylgeranylation of proteins.	Sesquiterpenes	95-108	farnesyl diphosphate synthase	Homo sapiens	0-29
15827605-1	2005	Farnesyl diphosphate synthase (FPPS) is a key enzyme in isoprenoid biosynthesis which supplies sesquiterpene precursors for several classes of essential metabolites including sterols, dolichols, ubiquinones and carotenoids as well as substrates for farnesylation and geranylgeranylation of proteins.	Sesquiterpenes	95-108	farnesyl diphosphate synthase	Homo sapiens	31-35
15466210-0	2004	Celastraceae sesquiterpenes as a new class of modulators that bind specifically to human P-glycoprotein and reverse cellular multidrug resistance.	Sesquiterpenes	13-27	ATP binding cassette subfamily B member 1	Homo sapiens	89-103
15466210-5	2004	Cytotoxicity assays using human MDR1-transfected NIH-3T3 cells allowed us to select the most potent sesquiterpenes reversing the in vitro resistance to daunomycin and vinblastine.	Sesquiterpenes	100-114	ATP binding cassette subfamily B member 1	Homo sapiens	32-36
15466210-7	2004	Moreover, sesquiterpenes inhibited at submicromolar concentrations the P-glycoprotein-mediated transport of [(3)H]colchicine and tetramethylrosamine in plasma membrane from CH(R)B30 cells and P-glycoprotein-enriched proteoliposomes, supporting that P-glycoprotein is their molecular target.	Sesquiterpenes	10-24	ATP binding cassette subfamily B member 1	Homo sapiens	71-85
15466210-7	2004	Moreover, sesquiterpenes inhibited at submicromolar concentrations the P-glycoprotein-mediated transport of [(3)H]colchicine and tetramethylrosamine in plasma membrane from CH(R)B30 cells and P-glycoprotein-enriched proteoliposomes, supporting that P-glycoprotein is their molecular target.	Sesquiterpenes	10-24	ATP binding cassette subfamily B member 1	Homo sapiens	192-206
15466210-7	2004	Moreover, sesquiterpenes inhibited at submicromolar concentrations the P-glycoprotein-mediated transport of [(3)H]colchicine and tetramethylrosamine in plasma membrane from CH(R)B30 cells and P-glycoprotein-enriched proteoliposomes, supporting that P-glycoprotein is their molecular target.	Sesquiterpenes	10-24	ATP binding cassette subfamily B member 1	Homo sapiens	192-206
16450294-0	2006	New sesquiterpene dimers from Inula britannica inhibit NF-kappaB activation and NO and TNF-alpha production in LPS-stimulated RAW264.7 cells.	Sesquiterpenes	4-17	tumor necrosis factor	Mus musculus	87-96
16378364-3	2005	The sesquiterpene chromone derivatives inhibited nitric oxide (NO) production and inducible NO synthase (iNOS) gene expression by a murine macrophage-like cell line (RAW 264.7), which was activated by lipopolysaccharide (LPS) and recombinant mouse interferon-gamma (IFN-gamma).	Sesquiterpenes	4-17	nitric oxide synthase 2, inducible	Mus musculus	82-103
16378364-3	2005	The sesquiterpene chromone derivatives inhibited nitric oxide (NO) production and inducible NO synthase (iNOS) gene expression by a murine macrophage-like cell line (RAW 264.7), which was activated by lipopolysaccharide (LPS) and recombinant mouse interferon-gamma (IFN-gamma).	Sesquiterpenes	4-17	nitric oxide synthase 2, inducible	Mus musculus	105-109
16378364-3	2005	The sesquiterpene chromone derivatives inhibited nitric oxide (NO) production and inducible NO synthase (iNOS) gene expression by a murine macrophage-like cell line (RAW 264.7), which was activated by lipopolysaccharide (LPS) and recombinant mouse interferon-gamma (IFN-gamma).	Sesquiterpenes	4-17	interferon gamma	Mus musculus	248-264
16378364-3	2005	The sesquiterpene chromone derivatives inhibited nitric oxide (NO) production and inducible NO synthase (iNOS) gene expression by a murine macrophage-like cell line (RAW 264.7), which was activated by lipopolysaccharide (LPS) and recombinant mouse interferon-gamma (IFN-gamma).	Sesquiterpenes	4-17	interferon gamma	Mus musculus	266-275
16227407-6	2005	Related sesquiterpenes have been shown to increase levels of reactive oxygen species (ROS) and to inhibit nuclear factor kappaB (NF-kappaB) transcriptional activity.	Sesquiterpenes	8-22	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	121-127
16227407-6	2005	Related sesquiterpenes have been shown to increase levels of reactive oxygen species (ROS) and to inhibit nuclear factor kappaB (NF-kappaB) transcriptional activity.	Sesquiterpenes	8-22	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	129-138
15849309-1	2005	In cotton (Gossypium hirsutum) the enzyme (+)-delta-cadinene synthase (CDNS) catalyzes the first committed step in the biosynthesis of cadinane-type sesquiterpenes, such as gossypol, that provide constitutive and inducible protection against pests and diseases.	Sesquiterpenes	149-163	(+)-delta-cadinene synthase	Gossypium hirsutum	42-69
15849309-8	2005	These results suggest that cdn1-C4 may be involved specifically in the bacterial blight response and that the CDNS multigene family comprises a complex set of genes differing in their temporal and spatial regulation and responsible for different branches of the cotton sesquiterpene pathway.	Sesquiterpenes	269-282	(+)-delta-cadinene synthase	Gossypium hirsutum	27-31
15787437-3	2005	The sesquiterpene phenylpropanoid derivatives inhibited nitric oxide (NO) production and inducible NO synthase (iNOS) gene expression by a murine macrophage-like cell line (RAW 264.7), which was activated by lipopolysaccharide (LPS) and recombinant mouse interferon-gamma (IFN-gamma).	Sesquiterpenes	4-17	nitric oxide synthase 2, inducible	Mus musculus	89-110
15787437-3	2005	The sesquiterpene phenylpropanoid derivatives inhibited nitric oxide (NO) production and inducible NO synthase (iNOS) gene expression by a murine macrophage-like cell line (RAW 264.7), which was activated by lipopolysaccharide (LPS) and recombinant mouse interferon-gamma (IFN-gamma).	Sesquiterpenes	4-17	nitric oxide synthase 2, inducible	Mus musculus	112-116
15787437-3	2005	The sesquiterpene phenylpropanoid derivatives inhibited nitric oxide (NO) production and inducible NO synthase (iNOS) gene expression by a murine macrophage-like cell line (RAW 264.7), which was activated by lipopolysaccharide (LPS) and recombinant mouse interferon-gamma (IFN-gamma).	Sesquiterpenes	4-17	interferon gamma	Mus musculus	255-271
15787437-3	2005	The sesquiterpene phenylpropanoid derivatives inhibited nitric oxide (NO) production and inducible NO synthase (iNOS) gene expression by a murine macrophage-like cell line (RAW 264.7), which was activated by lipopolysaccharide (LPS) and recombinant mouse interferon-gamma (IFN-gamma).	Sesquiterpenes	4-17	interferon gamma	Mus musculus	273-282
16178749-8	2005	In this review we describe a rational strategy developed to find specific Pgp-MDR modulators in Leishmania, using natural and semisynthetic dihydro-beta-agarofuran sesquiterpenes from Celastraceae plants.	Sesquiterpenes	164-178	phosphoglycolate phosphatase	Homo sapiens	74-77
16178749-11	2005	The three-dimensional quantitative structure-activity relationship using the comparative molecular similarity indices analysis (CoMSIA), was employed to characterize the requirements of these sesquiterpenes as modulators at Pgp-like transporter in Leishmania.	Sesquiterpenes	192-206	phosphoglycolate phosphatase	Homo sapiens	224-227
15466210-8	2004	Photoaffinity labeling in plasma membrane and fluorescence spectroscopy experiments with purified protein suggested that sesquiterpenes interact with transmembrane domains of P-glycoprotein.	Sesquiterpenes	121-135	ATP binding cassette subfamily B member 1	Homo sapiens	175-189
15466210-9	2004	Finally, sesquiterpenes modulated P-glycoprotein ATPase-activity in a biphasic, concentration-dependent manner: they stimulated at very low concentrations but inhibited ATPase activity as noncompetitive inhibitors at higher concentrations.	Sesquiterpenes	9-23	ATP binding cassette subfamily B member 1	Homo sapiens	34-48
15466210-10	2004	Sesquiterpenes from Celastraceae are promising P-glycoprotein modulators with potential applications in cancer chemotherapy because of their MDR reversal potency and specificity for P-glycoprotein.	Sesquiterpenes	0-14	ATP binding cassette subfamily B member 1	Homo sapiens	47-61
15466210-10	2004	Sesquiterpenes from Celastraceae are promising P-glycoprotein modulators with potential applications in cancer chemotherapy because of their MDR reversal potency and specificity for P-glycoprotein.	Sesquiterpenes	0-14	ATP binding cassette subfamily B member 1	Homo sapiens	182-196
15467238-3	2004	The 80% aqueous methanol extract of the roots of Ferula fukanensis (FFE) and the sesquiterpene coumarin derivatives inhibited nitric oxide (NO) production and inducible NO synthase (iNOS) gene expression by a murine macrophage-like cell line (RAW 264.7), which was activated by lipopolysaccharide (LPS) and recombinant mouse interferon-gamma (IFN-gamma).	Sesquiterpenes	81-94	interferon gamma	Mus musculus	343-352
15279995-12	2004	The complex sesquiterpene mixture of group D is identical to the products formed by the previously identified terpene synthase TPS4, suggesting that each of the four other sesquiterpene hydrocarbon mixtures may also represent the products of a single terpene synthase.	Sesquiterpenes	12-25	terpene synthase 4	Zea mays	127-131
15310834-10	2004	For example, lipoxygenase cDNA clones clustered with the volatile (Z)-3-hexenyl acetate and the volatile sesquiterpene (E,E)- alpha-farnesene clustered with an up-regulated sesquiterpene synthase fragment.	Sesquiterpenes	105-118	LOW QUALITY PROTEIN: linoleate 9S-lipoxygenase 6	Cucumis sativus	13-25
15270556-0	2004	Sesquiterpenes and flavonol glycosides from Zingiber aromaticum and their CYP3A4 and CYP2D6 inhibitory activities.	Sesquiterpenes	0-14	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	74-80
12762808-0	2003	New sesquiterpene quinols from a Micronesian sponge, Aka sp.	Sesquiterpenes	4-17	neurogenin 1	Homo sapiens	53-56
15270556-0	2004	Sesquiterpenes and flavonol glycosides from Zingiber aromaticum and their CYP3A4 and CYP2D6 inhibitory activities.	Sesquiterpenes	0-14	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	85-91
15133151-10	2004	These results suggest that GaWRKY1 participates in regulation of sesquiterpene biosynthesis in cotton, and CAD1-A is a target gene of this transcription factor.	Sesquiterpenes	65-78	cinnamyl alcohol dehydrogenase 1	Gossypium hirsutum	107-111
15075399-4	2004	The encoded enzymes, TPS4 and TPS5, each formed the same complex mixture of sesquiterpenes from the precursor farnesyl diphosphate but with different proportions of products.	Sesquiterpenes	76-90	terpene synthase 4	Zea mays	21-25
15075399-4	2004	The encoded enzymes, TPS4 and TPS5, each formed the same complex mixture of sesquiterpenes from the precursor farnesyl diphosphate but with different proportions of products.	Sesquiterpenes	76-90	Inactive sesquithujene synthase	Zea mays	30-34
11272823-3	2001	A 40644 possessing a sesquiterpene-substituted p-benzoquinone structure with cis-fused B/C ring stereochemistry that inhibits the human thioredoxin system as the well as the growth of several cancer cell lines.	Sesquiterpenes	21-34	thioredoxin	Homo sapiens	136-147
11697139-11	2001	We propose a model, based on the known reactions of GSTs and sesquiterpenes, in which (1) artemisinin reacts with GSH resulting in oxidised glutathione; (2) the oxidised glutathione is then converted to reduced glutathione via glutathione reductase; and (3) the latter reaction may then result in the depletion of NADPH via GSSG-reductase.	Sesquiterpenes	61-75	glutathione-disulfide reductase	Homo sapiens	227-248
11696190-0	2001	Molecular cloning and functional identification of (+)-delta-cadinene-8-hydroxylase, a cytochrome P450 mono-oxygenase (CYP706B1) of cotton sesquiterpene biosynthesis.	Sesquiterpenes	139-152	cytochrome P450 CYP82D47-like	Gossypium hirsutum	87-117
11374954-0	2001	New sesquiterpene derivatives from the sponge Dysidea species with a selective inhibitor profile against human phospholipase A2 and other leukocyte functions.	Sesquiterpenes	4-17	phospholipase A2 group IB	Homo sapiens	111-127
12398545-0	2002	Absolute stereostructures of three new sesquiterpenes from the fruit of Alpinia oxyphylla with inhibitory effects on nitric oxide production and degranulation in RBL-2H3 cells.	Sesquiterpenes	39-53	RB transcriptional corepressor like 2	Rattus norvegicus	162-167
12009027-2	2002	Three pseudoguaianolide type sesquiterpenes, bigelovin (1), 2,3-dihydroaromaticin (2), and ergolide (3) were isolated as inhibitory constituents against inducible nitric oxide synthase (iNOS) from the flowers of Inula britannica var.	Sesquiterpenes	29-43	nitric oxide synthase 2, inducible	Mus musculus	186-190
11106370-4	2000	We have cloned a maize sesquiterpene cyclase gene, stc1, by transposon tagging and have identified two deletion mutations of the gene.	Sesquiterpenes	23-36	sesquiterpene cyclase 1	Zea mays	51-55
10938353-1	2000	Farnesyl pyrophosphate synthase (FPS) catalyzes the synthesis of farnesyl pyrophosphate, a key intermediate in sterol and sesquiterpene biosynthesis.	Sesquiterpenes	122-135	farnesyl pyrophosphate synthase	Solanum lycopersicum	0-31
10938353-1	2000	Farnesyl pyrophosphate synthase (FPS) catalyzes the synthesis of farnesyl pyrophosphate, a key intermediate in sterol and sesquiterpene biosynthesis.	Sesquiterpenes	122-135	farnesyl pyrophosphate synthase	Solanum lycopersicum	33-36
10704251-3	2000	Because activation of NF-kappaB is involved in the regulation of the chemokine interleukin 8 (IL-8), we hypothesized that the sesquiterpene lactones, isohelenin and parthenolide, would inhibit IL-8 gene expression in cultured human respiratory epithelium.	Sesquiterpenes	126-139	nuclear factor kappa B subunit 1	Homo sapiens	22-31
18726379-6	2000	The CAD1 gene expression in G.arboreum seedlings and the spatial pattern of sesquiterpene biosynthesis constitute a chemical defense machinery in cotton seedlings.	Sesquiterpenes	76-89	probable cinnamyl alcohol dehydrogenase 1	Nicotiana tabacum	4-8
10704251-3	2000	Because activation of NF-kappaB is involved in the regulation of the chemokine interleukin 8 (IL-8), we hypothesized that the sesquiterpene lactones, isohelenin and parthenolide, would inhibit IL-8 gene expression in cultured human respiratory epithelium.	Sesquiterpenes	126-139	C-X-C motif chemokine ligand 8	Homo sapiens	193-197
10704251-3	2000	Because activation of NF-kappaB is involved in the regulation of the chemokine interleukin 8 (IL-8), we hypothesized that the sesquiterpene lactones, isohelenin and parthenolide, would inhibit IL-8 gene expression in cultured human respiratory epithelium.	Sesquiterpenes	126-139	C-X-C motif chemokine ligand 8	Homo sapiens	79-92
10704251-3	2000	Because activation of NF-kappaB is involved in the regulation of the chemokine interleukin 8 (IL-8), we hypothesized that the sesquiterpene lactones, isohelenin and parthenolide, would inhibit IL-8 gene expression in cultured human respiratory epithelium.	Sesquiterpenes	126-139	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
10587294-1	1999	MGI 114 (6-hydroxymethylacylfulvene, HMAF) is a novel semisynthetic antitumor compound derived from the sesquiterpene mushroom toxin illudin S. Although illudins did not demonstrate significant activity as antiproliferative agents in tumor-bearing animals, several properties including its potent inhibition of DNA synthesis and a unique interaction with DNA led to a structure-activity-based synthetic effort to obtain analogs with improved therapeutic potential.	Sesquiterpenes	104-117	MAF bZIP transcription factor G	Homo sapiens	37-41
10462483-5	1999	In the current studies we determined if the sesquiterpene lactones, parthenolide and isohelenin, modulate iNOS gene expression in cultured rat aortic smooth muscle cells (RASMC) treated with lipopolysaccharide and interferon-gamma.	Sesquiterpenes	44-57	nitric oxide synthase 2	Rattus norvegicus	106-110
10514328-0	1999	New nitrogenous bisabolene-type sesquiterpenes from a micronesian marine sponge, axinyssa species Chemical investigation of an Axinyssa species of sponge collected at Yap Island afforded three new nitrogenous sesquiterpenes, 1-3, together with the known compound 3-formamidotheonellin (4).	Sesquiterpenes	32-46	Yes1 associated transcriptional regulator	Homo sapiens	167-170
10075752-8	1999	This investigation indicates that, in developing seeds of the glanded cotton cultivar, genes of both the CAD1-C and CAD1-A subfamilies are expressed and there is an active biosynthesis of cadinene-type sesquiterpenes.	Sesquiterpenes	202-216	cinnamyl alcohol dehydrogenase 1	Gossypium hirsutum	105-109
10193198-0	1999	A sesquiterpene, dehydrocostus lactone, inhibits the expression of inducible nitric oxide synthase and TNF-alpha in LPS-activated macrophages.	Sesquiterpenes	2-15	tumor necrosis factor	Mus musculus	103-112
10075752-8	1999	This investigation indicates that, in developing seeds of the glanded cotton cultivar, genes of both the CAD1-C and CAD1-A subfamilies are expressed and there is an active biosynthesis of cadinene-type sesquiterpenes.	Sesquiterpenes	202-216	cinnamyl alcohol dehydrogenase 1	Gossypium hirsutum	116-120
7784459-2	1995	Assorted monoterpenes, sesquiterpenes, carotenoids and tocotrienols down regulate, post-transcriptionally, 3-hydroxy-3-methylglutaryl coenzyme A reductase activity thereby modestly decreasing cholesterol synthesis and concomitantly decreasing LDL cholesterol.	Sesquiterpenes	23-37	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	107-154
9644066-1	1998	In the course of our screening for small molecule modulators of erythropoietin gene expression, two novel sesquiterpene tropolones and pycnidone were isolated from a culture of OS-F69284 (ATCC 74390).	Sesquiterpenes	106-119	erythropoietin	Homo sapiens	64-78
9539701-1	1998	This review focuses on the monoterpene, sesquiterpene, and diterpene synthases of plant origin that use the corresponding C10, C15, and C20 prenyl diphosphates as substrates to generate the enormous diversity of carbon skeletons characteristic of the terpenoid family of natural products.	Sesquiterpenes	40-53	homeobox C10	Homo sapiens	122-125
9539701-1	1998	This review focuses on the monoterpene, sesquiterpene, and diterpene synthases of plant origin that use the corresponding C10, C15, and C20 prenyl diphosphates as substrates to generate the enormous diversity of carbon skeletons characteristic of the terpenoid family of natural products.	Sesquiterpenes	40-53	placenta associated 8	Homo sapiens	127-130
17252474-3	1996	This appears to be the first sesquiterpene nicotinoyl alkaloid based on hydroxywilfordic acid with a benzoyl group at C-5.	Sesquiterpenes	29-42	complement C5	Homo sapiens	118-121
7782923-2	1995	Assorted monoterpenes, sesquiterpenes, carotenoids and tocotrienols posttranscriptionally down regulate 3-hydroxy-3-methylglutaryl coenzyme A reductase activity, a key activity in the sterologenic pathway.	Sesquiterpenes	23-37	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	104-151
34778972-1	2021	beta-caryophyllene (BCP), a natural sesquiterpene present in plants, is a selective agonist of cannabinoid receptor type-2 (CB2) of the endocannabinoid system.	Sesquiterpenes	36-49	cannabinoid receptor 2 (macrophage)	Mus musculus	124-127
34889472-4	2022	PT is a sesquiterpenoid responsible for alkylation of adenine of codon 61 of gene H-Ras, which results in Glutamine 61 substitution that is essential for guanosine triphosphate (GTP) hydrolysis.	Sesquiterpenes	8-23	HRas proto-oncogene, GTPase	Bos taurus	82-87
7902582-2	1993	In search of a reagent that could discriminate between these two effects, we used the sesquiterpene antibiotic koningic acid, which binds to GAPDH at the Cys-149 of the active site.	Sesquiterpenes	86-99	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	141-146
2015292-1	1991	The sesquiterpene antibiotic koningic acid (heptelidic acid) has been previously demonstrated to modify glyceraldehyde-3-phosphate dehydrogenase in specific manner, probably by binding to the sulfhydryl residue at the active site of the enzyme (Sakai, K., Hasumi, K. and Endo, A.	Sesquiterpenes	4-17	glyceraldehyde-3-phosphate dehydrogenase	Oryctolagus cuniculus	104-144
34499421-0	2021	Auxin-mediated induction of GAL promoters by conditional degradation of Mig1p improves sesquiterpene production in Saccharomyces cerevisiae with engineered acetyl-CoA synthesis.	Sesquiterpenes	87-100	transcription factor MIG1	Saccharomyces cerevisiae S288C	72-77
34805098-0	2021	Sesquiterpenes From Oplopanax elatus Stems and Their Anti-Photoaging Effects by Down-Regulating Matrix Metalloproteinase-1 Expression via Anti-Inflammation.	Sesquiterpenes	0-14	matrix metallopeptidase 1	Homo sapiens	96-122
34351742-0	2021	Aromatic Cadinane Sesquiterpenoids from the Fruiting Bodies of Phellinus pini Block SARS-CoV-2 Spike-ACE2 Interaction.	Sesquiterpenes	18-34	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	95-100
34841171-0	2021	WSF-CT-11, a Sesquiterpene Derivative, Activates AMP-Activated Protein Kinase with Anti-diabetic Effects in 3T3-L1 Adipocytes.	Sesquiterpenes	13-26	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	49-77
34351742-0	2021	Aromatic Cadinane Sesquiterpenoids from the Fruiting Bodies of Phellinus pini Block SARS-CoV-2 Spike-ACE2 Interaction.	Sesquiterpenes	18-34	angiotensin converting enzyme 2	Homo sapiens	101-105
34351742-4	2021	All of the aromatic cadinane sesquiterpenoids inhibited the SARS-CoV-2 spike-ACE2 interaction, with IC50 values ranging from 64.5 to 99.1 muM.	Sesquiterpenes	29-45	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	71-76
34351742-4	2021	All of the aromatic cadinane sesquiterpenoids inhibited the SARS-CoV-2 spike-ACE2 interaction, with IC50 values ranging from 64.5 to 99.1 muM.	Sesquiterpenes	29-45	angiotensin converting enzyme 2	Homo sapiens	77-81
34179914-0	2021	Bisabolane-type sesquiterpenoids from Curcuma longa L. exert anti-influenza and anti-inflammatory activities through NF-kappaB/MAPK and RIG-1/STAT1/2 signaling pathways.	Sesquiterpenes	16-32	nuclear factor kappa B subunit 1	Homo sapiens	117-126
34179914-0	2021	Bisabolane-type sesquiterpenoids from Curcuma longa L. exert anti-influenza and anti-inflammatory activities through NF-kappaB/MAPK and RIG-1/STAT1/2 signaling pathways.	Sesquiterpenes	16-32	roundabout guidance receptor 3	Homo sapiens	136-141
34179914-0	2021	Bisabolane-type sesquiterpenoids from Curcuma longa L. exert anti-influenza and anti-inflammatory activities through NF-kappaB/MAPK and RIG-1/STAT1/2 signaling pathways.	Sesquiterpenes	16-32	signal transducer and activator of transcription 1	Homo sapiens	142-149
34179914-8	2021	These findings indicate that bisabolane-type sesquiterpenoids of C. longa could inhibit the expression of inflammatory cytokines induced by the virus and regulate the activity of NF-kappaB/MAPK and RIG-1/STAT-1/2 signaling pathways in vitro.	Sesquiterpenes	45-61	nuclear factor kappa B subunit 1	Homo sapiens	179-188
34179914-8	2021	These findings indicate that bisabolane-type sesquiterpenoids of C. longa could inhibit the expression of inflammatory cytokines induced by the virus and regulate the activity of NF-kappaB/MAPK and RIG-1/STAT-1/2 signaling pathways in vitro.	Sesquiterpenes	45-61	roundabout guidance receptor 3	Homo sapiens	198-203
34203809-7	2021	REOLv and its primary sesquiterpenes (viridiflorol, spathulenol, curzerene, and germacrone) induced intracellular Ca2+ mobilization in human neutrophils, C20 microglial cells, and HL60 cells transfected with N-formyl peptide receptor 1 (FPR1) or FPR2.	Sesquiterpenes	22-36	formyl peptide receptor 1	Homo sapiens	237-241
34237075-5	2021	Further analysis showed that the first three Ors are activated by pyrethrins, the major insecticidal components in pyrethrum, whereas Or98a is activated by (E)-beta-farnesene (EBF), a sesquiterpene and a minor component in pyrethrum.	Sesquiterpenes	184-197	Odorant receptor 98a	Drosophila melanogaster	134-139
34203809-7	2021	REOLv and its primary sesquiterpenes (viridiflorol, spathulenol, curzerene, and germacrone) induced intracellular Ca2+ mobilization in human neutrophils, C20 microglial cells, and HL60 cells transfected with N-formyl peptide receptor 1 (FPR1) or FPR2.	Sesquiterpenes	22-36	formyl peptide receptor 2	Homo sapiens	246-250
35631467-8	2022	Further analysis of unique compounds found in A. dracunculus showed that farnesene, a compound with a similar hydrocarbon structure as lipoxin A4, inhibited Ca2+ influx induced in human neutrophils by fMLF (IC50 = 1.2 muM), WKYMVM (IC50 = 1.4 muM), or interleukin 8 (IC50 = 2.6 muM).	Sesquiterpenes	73-82	C-X-C motif chemokine ligand 8	Homo sapiens	252-265
34068304-5	2021	Among the species reviewed, we highlight Psacalium decompositum (Asteraceae), due to the potent hypoglycemic, anti-inflammatory, and antioxidant activity of the sesquiterpenes identified as majority compounds isolated from the root, such as cacalol and cacalone that also possess the capacity of increasing insulin levels.	Sesquiterpenes	161-175	insulin	Homo sapiens	307-314
35473521-4	2022	MATERIALS AND METHODS: PC12 cells were simultaneously treated with 400 muM H2O2 and sesquiterpenoid compounds or vitamin E (used as a positive control) for 24 h. The activities of GSH-Px, LDH, CAT, and SOD were detected by ELISA kits.	Sesquiterpenes	84-99	catalase	Rattus norvegicus	193-196
35604429-0	2022	Sesquiterpene from Polygonum barbatum disrupts mitochondrial membrane potential to induce apoptosis and inhibits metastasis by downregulating matrix metalloproteinase and osteopontin in NCI-H460 cells.	Sesquiterpenes	0-13	secreted phosphoprotein 1	Homo sapiens	171-182
35473521-8	2022	RESULTS: Twenty-one sesquiterpenoids from the radix of C. aromatica all increased the activities of GSH-Px, CAT, and SOD, and decreased the LDH leakage, and levels of ROS level and (Ca2+)i to different degrees.	Sesquiterpenes	20-36	catalase	Rattus norvegicus	108-111
35173042-0	2022	Cultivated human intestinal fungus Candida metapsilosis M2006B attenuates colitis by secreting acyclic sesquiterpenoids as FXR agonists.	Sesquiterpenes	103-119	nuclear receptor subfamily 1, group H, member 4	Mus musculus	123-126
35173042-7	2022	Among the seven acyclic sesquiterpenoids (F1-F7) identified as major secondary metabolites of M2006B, F4 and F5 attenuated colitis in mice by acting as novel FXR agonists.	Sesquiterpenes	24-40	nuclear receptor subfamily 1, group H, member 4	Mus musculus	158-161
35205173-2	2022	There are research interests in recent years on terpene-derived metabolites (diterpenes, triterpenes and sesquiterpenes), which are believed to serve as excellent cholinesterase inhibitors.	Sesquiterpenes	105-119	butyrylcholinesterase	Homo sapiens	163-177
35573878-9	2022	This bioactive molecular network provided a panoramic view of FJHQD"s ACE inhibitory activities, which demonstrated that flavones from Astragali Radix and Glycyrrhizae Radix et Rhizoma, saponins from Astragali Radix, and sesquiterpenoids from Atractylodis Macrocephalae Rhizoma were principal components responsible for this effect of FJHQD.	Sesquiterpenes	221-237	angiotensin I converting enzyme	Homo sapiens	70-73