PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
28102849-6	2017	BBR-SDT also reduced the phosphorylation of Akt and mTOR, two key molecules in the PI3K/AKT/mTOR signaling pathway, which is responsible for inducing autophagy.	bbr-sdt	0-7	AKT serine/threonine kinase 1	Homo sapiens	44-47
28102849-6	2017	BBR-SDT also reduced the phosphorylation of Akt and mTOR, two key molecules in the PI3K/AKT/mTOR signaling pathway, which is responsible for inducing autophagy.	bbr-sdt	0-7	mechanistic target of rapamycin kinase	Homo sapiens	52-56
28102849-6	2017	BBR-SDT also reduced the phosphorylation of Akt and mTOR, two key molecules in the PI3K/AKT/mTOR signaling pathway, which is responsible for inducing autophagy.	bbr-sdt	0-7	AKT serine/threonine kinase 1	Homo sapiens	88-91
28102849-6	2017	BBR-SDT also reduced the phosphorylation of Akt and mTOR, two key molecules in the PI3K/AKT/mTOR signaling pathway, which is responsible for inducing autophagy.	bbr-sdt	0-7	mechanistic target of rapamycin kinase	Homo sapiens	92-96
28102849-8	2017	Furthermore, induction of cholesterol efflux by BBR-SDT was reversed by an inhibition of autophagy by 3-methyladenine or by a small interfering RNA targeting Atg5.	bbr-sdt	48-55	autophagy related 5	Homo sapiens	158-162
28102849-9	2017	Taken together, these results demonstrate that BBR-SDT effectively promotes cholesterol efflux by increasing reactive oxygen species generation, and this subsequently induces autophagy via the PI3K/AKT/mTOR signaling pathway in both "normal" macrophages and lipid-loaded macrophages (foam cells).	bbr-sdt	47-54	AKT serine/threonine kinase 1	Homo sapiens	198-201
28102849-9	2017	Taken together, these results demonstrate that BBR-SDT effectively promotes cholesterol efflux by increasing reactive oxygen species generation, and this subsequently induces autophagy via the PI3K/AKT/mTOR signaling pathway in both "normal" macrophages and lipid-loaded macrophages (foam cells).	bbr-sdt	47-54	mechanistic target of rapamycin kinase	Homo sapiens	202-206