PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
2574996-4	1989	In order to investigate the mechanism by which the cytolysin causes cell lysis, we have prepared a highly active [3H]cytolysin derivative by reductive methylation with sodium cyanoborohydride and [3H]formaldehyde.	Formaldehyde	200-212	perforin 1	Homo sapiens	51-60
2574996-4	1989	In order to investigate the mechanism by which the cytolysin causes cell lysis, we have prepared a highly active [3H]cytolysin derivative by reductive methylation with sodium cyanoborohydride and [3H]formaldehyde.	Formaldehyde	200-212	perforin 1	Homo sapiens	117-126
2607150-2	1989	Dot-immunobinding assay for anti-calmodulin (CaM), and immunoblot assay for CaM have become feasible by proper choice of a fixative, i.e., formaldehyde vapor.	Formaldehyde	139-151	calmodulin 1	Rattus norvegicus	76-79
2590213-0	1989	A gastrin-releasing peptide antagonist containing A psi (CH2O) amide bond surrogate.	Formaldehyde	57-61	gastrin releasing peptide	Homo sapiens	2-27
2483185-3	1989	Formalin-paraffin sections of both tumors were stained positively by PSA (prostatic specific antigen) and PAP (prostatic acid phosphatase) using B-SA (biotin-streptavidin) system technique and prostatic origin of the breast mass was confirmed.	Formaldehyde	0-8	acid phosphatase 3	Homo sapiens	106-109
2483185-3	1989	Formalin-paraffin sections of both tumors were stained positively by PSA (prostatic specific antigen) and PAP (prostatic acid phosphatase) using B-SA (biotin-streptavidin) system technique and prostatic origin of the breast mass was confirmed.	Formaldehyde	0-8	acid phosphatase 3	Homo sapiens	111-137
2590213-1	1989	The [Leu26-psi(CH2O)Leu27] derivative of N-Ac-GRP20-27-peptide amide was prepared and evaluated as a gastrin-releasing peptide antagonist.	Formaldehyde	15-19	gastrin releasing peptide	Homo sapiens	101-126
2615191-4	1989	Free water clearance (CH2O) was used as an estimate of TAL transport activity; the CH2O observed during 90 minute perfusions was found to be predictive of the extent of TAL necrosis in each experiment.	Formaldehyde	83-87	leucine rich repeat and sterile alpha motif containing 1	Homo sapiens	169-172
2816820-4	1989	Immunohistochemical ER was assessed in 68 breast carcinomas, by an automated method using routinely processed formalin-fixed paraffin-embedded tissues, and manually with the use of snap-frozen tissues with a monoclonal anti-ER and peroxidase-antiperoxidase technique.	Formaldehyde	110-118	estrogen receptor 1	Homo sapiens	20-22
2583860-6	1989	Immunohistochemical analysis of formalin-fixed paraffin sections, using a polyclonal antibody against pS2 protein, showed specific staining of both cytoplasm and membrane of epithelial cells in the neck region of antral and body glands as well as in luminal secretions.	Formaldehyde	32-40	taste 2 receptor member 64 pseudogene	Homo sapiens	102-105
2790701-2	1989	A new immunohistochemical assay using a monoclonal estrogen receptor (ER) antibody (H222, Abbott Laboratories, North Chicago) for determination of ER in formalin-fixed paraffin-embedded tissue was applied to evaluate its clinical value in a group of 145 previously untreated patients with advanced breast cancer.	Formaldehyde	153-161	estrogen receptor 1	Homo sapiens	70-72
2790701-2	1989	A new immunohistochemical assay using a monoclonal estrogen receptor (ER) antibody (H222, Abbott Laboratories, North Chicago) for determination of ER in formalin-fixed paraffin-embedded tissue was applied to evaluate its clinical value in a group of 145 previously untreated patients with advanced breast cancer.	Formaldehyde	153-161	estrogen receptor 1	Homo sapiens	147-149
2790701-7	1989	It is concluded that ER analysis in formalin-fixed paraffin-embedded tissue offers clinically useful information for allocation of patients to endocrine therapy.	Formaldehyde	36-44	estrogen receptor 1	Homo sapiens	21-23
2617474-1	1989	In order to analyze the interaction of platelets with von Willebrand factor (vWF) and collagen, we studied the binding of glycocalicin (GC) and formalin-fixed platelets to vWF adsorbed onto uncoated or collagen-coated polystyrene surfaces.	Formaldehyde	144-152	von Willebrand factor	Homo sapiens	172-175
2612565-1	1989	Intraplantar administration of serotonin 5-HT3 receptor antagonists ICS 205-930 and MDL 72222 (1-100 micrograms; 50 microliters) produced dose-related analgesia against formalin-induced acute- and Freunds adjuvant-induced chronic-inflammatory pain in rats.	Formaldehyde	169-177	5-hydroxytryptamine receptor 3A	Rattus norvegicus	41-55
2477085-0	1989	BER-H2: a new anti-Ki-1 (CD30) monoclonal antibody directed at a formol-resistant epitope.	Formaldehyde	65-71	TNF receptor superfamily member 8	Homo sapiens	19-23
2477085-0	1989	BER-H2: a new anti-Ki-1 (CD30) monoclonal antibody directed at a formol-resistant epitope.	Formaldehyde	65-71	TNF receptor superfamily member 8	Homo sapiens	25-29
2477085-4	1989	Therefore, it was possible to investigate an unprecedented number of tumors received as frozen or formaldehyde-fixed material for expression of the CD30 antigen.	Formaldehyde	98-110	TNF receptor superfamily member 8	Homo sapiens	148-152
2674299-5	1989	Using polyclonal antibodies and the avidin-biotin peroxidase complex, we demonstrated the presence of both IL-1 alpha and IL-1 beta in normal and psoriatic formalin-fixed paraffin-embedded tissues.	Formaldehyde	156-164	interleukin 1 alpha	Homo sapiens	107-117
2674299-5	1989	Using polyclonal antibodies and the avidin-biotin peroxidase complex, we demonstrated the presence of both IL-1 alpha and IL-1 beta in normal and psoriatic formalin-fixed paraffin-embedded tissues.	Formaldehyde	156-164	interleukin 1 beta	Homo sapiens	122-131
2480625-1	1989	A peroxidase antiperoxidase technique was used to identify alpha 2-macroglobulin in formalin-fixed sections of normal equine lung and liver and in tissue sections and bronchoalveolar lavage fluid from horses with various lung diseases.	Formaldehyde	84-92	alpha-2-macroglobulin	Equus caballus	59-80
2806555-1	1989	Formaldehyde dehydrogenase (EC 1.2.1.1) is a widely occurring enzyme which catalyzes the oxidation of S-hydroxymethylglutathione, formed from formaldehyde and glutathione, into S-formyglutathione in the presence of NAD.	Formaldehyde	142-154	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	0-26
2483748-4	1989	S100 protein, prostate specific antigen, thyroglobulin and carcinoembryonic antigen were more resilient and showed weak staining after 14 days exposure to formaldehyde.	Formaldehyde	155-167	S100 calcium binding protein A1	Homo sapiens	0-4
2780051-7	1989	Furthermore, amplification of neu and the epidermal growth factor receptor gene could be detected in as few as 100 breast carcinoma cells or in single sections of formalin-fixed, embedded material.	Formaldehyde	163-171	erb-b2 receptor tyrosine kinase 2	Homo sapiens	30-33
2575456-10	1989	In contrast, in formaldehyde-fixed tissues, the cyclin/PCNA labelling index markedly exceeded the [3H]-thymidine labelling index.	Formaldehyde	16-28	proliferating cell nuclear antigen	Homo sapiens	48-54
2575456-10	1989	In contrast, in formaldehyde-fixed tissues, the cyclin/PCNA labelling index markedly exceeded the [3H]-thymidine labelling index.	Formaldehyde	16-28	proliferating cell nuclear antigen	Homo sapiens	55-59
2575456-11	1989	From this it is concluded that cyclin/PCNA immunostaining can be used: (1) In formaldehyde-fixed tissues (including existing material stored as paraffin blocks): for defining and mapping the proliferative (or germinative) compartment.	Formaldehyde	78-90	proliferating cell nuclear antigen	Homo sapiens	31-37
2575456-11	1989	From this it is concluded that cyclin/PCNA immunostaining can be used: (1) In formaldehyde-fixed tissues (including existing material stored as paraffin blocks): for defining and mapping the proliferative (or germinative) compartment.	Formaldehyde	78-90	proliferating cell nuclear antigen	Homo sapiens	38-42
2794085-0	1989	Molecule detected in formalin fixed tissue by antibodies MT1, DF-T1, and L60 (Leu-22) corresponds to CD43 antigen.	Formaldehyde	21-29	metallothionein 1I, pseudogene	Homo sapiens	57-60
2794085-0	1989	Molecule detected in formalin fixed tissue by antibodies MT1, DF-T1, and L60 (Leu-22) corresponds to CD43 antigen.	Formaldehyde	21-29	sialophorin	Homo sapiens	101-105
2770757-3	1989	Stimulation of H2O2 production by BHA in S9 or microsome incubation mixtures was demonstrated using the catalase-mediated production of formaldehyde from methanol.	Formaldehyde	136-148	catalase	Cricetulus griseus	104-112
2780051-7	1989	Furthermore, amplification of neu and the epidermal growth factor receptor gene could be detected in as few as 100 breast carcinoma cells or in single sections of formalin-fixed, embedded material.	Formaldehyde	163-171	epidermal growth factor receptor	Homo sapiens	42-74
2774054-1	1989	In formalin-fixed, paraffin-embedded synovial tissues from patients with early proliferative rheumatoid arthritis (RA), immunoreactivity could be demonstrated utilizing monoclonal IgG antibodies reactive with the p19 and p24 protein of human T cell leukemia virus (HTLV-I).	Formaldehyde	3-11	interleukin 23 subunit alpha	Homo sapiens	213-216
2669324-6	1989	Ecotropic receptors still bound gp70 specifically after cells were fixed with 3.7% formaldehyde, but these receptors could not be patched, indicating that they were nondiffusible.	Formaldehyde	83-95	embigin	Mus musculus	32-36
2731976-2	1989	We report that viable or Formalin-killed spherules of Coccidioides immitis induced the secretion of TNF-alpha by peritoneal-exudate cells from BALB/c mice.	Formaldehyde	25-33	tumor necrosis factor	Mus musculus	100-109
2787029-4	1989	However, the viable bacteria required about 1 log lower concentrations than the formalin-killed bacteria to induce the same level of IL-1 activity measured in the thymocyte proliferation assay.	Formaldehyde	80-88	interleukin 1 complex	Mus musculus	133-137
2466563-1	1989	An IgG1 murine monoclonal antibody (PN-15) to an epitope preserved in formalin-fixed, paraffin-embedded tissue sections of renal cell carcinomas was developed following immunization of mice with the microsomal fraction of human renal cortical tissue homogenates.	Formaldehyde	70-78	LOC105243590	Mus musculus	3-7
2500128-6	1989	The turnover numbers for the metabolism of DMA and DMA N-oxide to formaldehyde by the reconstituted system containing cytochrome P-450 form 2 were 25.6 and 3.4 nmol/min/nmol cytochrome P-450, respectively.	Formaldehyde	66-78	cytochrome P-450	Oryctolagus cuniculus	118-134
2500128-6	1989	The turnover numbers for the metabolism of DMA and DMA N-oxide to formaldehyde by the reconstituted system containing cytochrome P-450 form 2 were 25.6 and 3.4 nmol/min/nmol cytochrome P-450, respectively.	Formaldehyde	66-78	cytochrome P-450	Oryctolagus cuniculus	174-190
2716766-0	1989	Formaldehyde-induced and spontaneous alterations in human hprt DNA sequence and mRNA expression.	Formaldehyde	0-12	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	58-62
2770746-1	1989	Using "protein-image" hybridization technique combined with various crosslinking methods, for formaldehyde-prefixed nuclei we have analysed changes induced by activation in the chromatin structure of HSP-70 genes.	Formaldehyde	94-106	Heat-shock-protein-70Ab	Drosophila melanogaster	200-206
2537288-4	1989	In contrast, nonenzymatically glucated bovine serum albumin (BSA) released about twice as much formaldehyde upon periodate oxidation as did nonenzymatically fructated BSA.	Formaldehyde	95-107	albumin	Homo sapiens	46-59
2714341-1	1989	Monoclonal antibodies against an estrogen-regulated Mr 24,000 cytosol protein (p24) were used for immunocytochemical localization of p24 in formalin-fixed paraffin-embedded specimens from the primary tumor in 103 patients who received endocrine therapy for advanced breast cancer.	Formaldehyde	140-148	transmembrane p24 trafficking protein 2	Homo sapiens	79-82
2714341-1	1989	Monoclonal antibodies against an estrogen-regulated Mr 24,000 cytosol protein (p24) were used for immunocytochemical localization of p24 in formalin-fixed paraffin-embedded specimens from the primary tumor in 103 patients who received endocrine therapy for advanced breast cancer.	Formaldehyde	140-148	transmembrane p24 trafficking protein 2	Homo sapiens	133-136
2661710-1	1989	The monoclonal antibody designated LN-1 was used in an attempt to identify the antigen in follicular center cell lymphomas using tissue sections fixed in formalin.	Formaldehyde	154-162	phytanoyl-CoA 2-hydroxylase	Homo sapiens	35-39
2750743-4	1989	Initial analysis showed that increases in age, years of cigarette smoking, and hours per day of formaldehyde exposure significantly lengthened CRT, but xylene-toluene exposure had no effect.	Formaldehyde	96-108	calcitonin receptor	Homo sapiens	143-146
2713135-5	1989	The demonstration of desmin by the monoclonal antibody which was used on the formaldehyde-fixed, paraffin-embedded material is of particular value in the diagnosis of rhabdomyosarcoma.	Formaldehyde	77-89	desmin	Homo sapiens	21-27
2751258-1	1989	The immunohistochemical expression of CEA in formalin-fixed paraffin sections in urinary bladder carcinomas was compared to the use of polyclonal anti-CEA antiserum (P-CEA), NCA-absorbed anti-CEA (NCA-aCEA) and monoclonal antibody to CEA (M-CEA).	Formaldehyde	45-53	CEA cell adhesion molecule 5	Homo sapiens	38-41
2748452-0	1989	Prognostic significance of vimentin positivity in formalin-fixed renal cell carcinomas.	Formaldehyde	50-58	vimentin	Homo sapiens	27-35
2647627-1	1989	The cellular distribution of immunoreactive interferon-alpha (IFN-alpha) was studied in formalin-fixed paraffin-embedded normal human tissues from 36 different organs.	Formaldehyde	88-96	interferon alpha 1	Homo sapiens	62-71
2644430-1	1989	Formalin-killed cells of Pseudomonas aeruginosa strain M-24 elicited an antibody-independent protective effect against P. aeruginosa infection in mice.	Formaldehyde	0-8	gasdermin D	Mus musculus	55-59
2472733-2	1989	Antigenicity of CK and vimentin was almost completely destroyed during formalin fixation in normal thyroid and all thyroid lesions except for some cases of papillary and squamous cell carcinoma, although the latter showed negative immunostaining with anti-vimentin antibody.	Formaldehyde	71-79	vimentin	Homo sapiens	23-31
2770616-7	1989	The previously suggested increase in haematologic neoplasms was confirmed (observed = 7; SMR = 143); the risk was highest among formaldehyde-exposed workers (observed = 3; SMR = 173).	Formaldehyde	128-140	LY6/PLAUR domain containing 4	Homo sapiens	89-92
2770616-7	1989	The previously suggested increase in haematologic neoplasms was confirmed (observed = 7; SMR = 143); the risk was highest among formaldehyde-exposed workers (observed = 3; SMR = 173).	Formaldehyde	128-140	LY6/PLAUR domain containing 4	Homo sapiens	172-175
2536017-3	1989	Chemical cross-linking of Mr 55,000 125I-uPA to the surface of HeLa and U937 cells with disuccinimidyl suberate or with formaldehyde results in the formation of a labeled complex of Mr 100,000, suggesting a Mr of 45,000 +/- 5,000 for the receptor or a subunit thereof.	Formaldehyde	120-132	plasminogen activator, urokinase	Homo sapiens	41-44
2464285-2	1989	Formalin-fixed, paraffin-embedded sections were pretreated with pronase and stained with a K19-specific antibody by the avidin-biotin immunoperoxidase method.	Formaldehyde	0-8	keratin 19	Homo sapiens	91-94
2750743-5	1989	Since duration of smoking and length of daily formaldehyde exposure were age related, multiple linear regression analysis of CRT was performed using them as independent variables.	Formaldehyde	46-58	calcitonin receptor	Homo sapiens	125-128
2462857-2	1989	Therefore, we evaluated the expression of p21 in formaldehyde-fixed, paraffin-embedded prostatic tissue using a commercially available polyclonal antiserum prepared in sheep.	Formaldehyde	49-61	H3 histone pseudogene 16	Homo sapiens	42-45
2470977-1	1989	The authors present the data that evidence in favour of employing fibronectin sensitized formalin-treated red cells for the indication of fibronectin-binding microorganisms (as exemplified by staphylococci) in the passive hemagglutination test (PHAT).	Formaldehyde	89-97	fibronectin 1	Homo sapiens	66-77
2712596-3	1989	Detection of CA 125 was most intense in cryostat sections and decreased in formalin fixed and paraffin embedded tissues according to the duration of fixation.	Formaldehyde	75-83	mucin 16, cell surface associated	Homo sapiens	13-19
2670616-11	1989	A weak reaction for desmin or its lack in the tumour cells of leiomyomas with its marked expression in the smooth muscle cells of the blood vessels and gastric wall outside the tumor points rather to a small number of desmin filaments in the neoplastic cells than to their destruction by fixation in formalin.	Formaldehyde	300-308	desmin	Homo sapiens	20-26
2550600-2	1989	To investigate the role of ras p21 product expression in human hepatocellular carcinoma (HCC), we have localized ras p21 in formalin fixed, paraffin-embedded normal and abnormal livers utilizing the avidin-biotin peroxidase method and a monoclonal antibody to ras-gene product p21.	Formaldehyde	124-132	H3 histone pseudogene 16	Homo sapiens	117-120
2550600-2	1989	To investigate the role of ras p21 product expression in human hepatocellular carcinoma (HCC), we have localized ras p21 in formalin fixed, paraffin-embedded normal and abnormal livers utilizing the avidin-biotin peroxidase method and a monoclonal antibody to ras-gene product p21.	Formaldehyde	124-132	H3 histone pseudogene 16	Homo sapiens	117-120
2754759-1	1989	In isolated, hemoglobin-free perfused livers of fasted rats, formaldehyde at an initial concentration of 10 mmol/l produced toxicity as evidenced by a release of enzymes (GPT, SDH) and of glutathione (mainly GSSG) into the perfusate, an accumulation of calcium in the liver, and a depletion of hepatic glutathione.	Formaldehyde	61-73	glutamic--pyruvic transaminase	Rattus norvegicus	171-174
2754759-1	1989	In isolated, hemoglobin-free perfused livers of fasted rats, formaldehyde at an initial concentration of 10 mmol/l produced toxicity as evidenced by a release of enzymes (GPT, SDH) and of glutathione (mainly GSSG) into the perfusate, an accumulation of calcium in the liver, and a depletion of hepatic glutathione.	Formaldehyde	61-73	serine dehydratase	Rattus norvegicus	176-179
2670616-2	1989	The aim of the study was to evaluate the incidence of the reactions for vimentin and desmin in gastric leiomyomas routinely processed in formalin and embedded i paraffin.	Formaldehyde	137-145	vimentin	Homo sapiens	72-80
2472367-2	1989	Ten out of 12 MAbs reacted with formaldehyde-fixed human ACTH[1-39] and fragments thereof.	Formaldehyde	32-44	pro-opiomelanocortin-alpha	Mus musculus	57-61
2470977-1	1989	The authors present the data that evidence in favour of employing fibronectin sensitized formalin-treated red cells for the indication of fibronectin-binding microorganisms (as exemplified by staphylococci) in the passive hemagglutination test (PHAT).	Formaldehyde	89-97	fibronectin 1	Homo sapiens	138-149
2615769-6	1989	The formaldehyde-induced complexes required degradation with DNase 1 for the resolution of histones on 2D gels and were not chemically labile like the metal-induced cross-links.	Formaldehyde	4-16	deoxyribonuclease-1	Cricetulus griseus	61-68
2499107-6	1989	In the present study we detected desmin in 6 of 10 formalin-fixed paraffin sections (although there were differences due to the use of five commercially available types of anti-desmin antibodies).	Formaldehyde	51-59	desmin	Homo sapiens	33-39
2468075-0	1989	[Immunocytochemical staining of estrogen receptor in conventional formalin-fixed paraffin sections in human breast cancer].	Formaldehyde	66-74	estrogen receptor 1	Homo sapiens	32-49
2468075-1	1989	Immunocytochemical staining for estrogen receptor (ER) was examined in conventional formalin-fixed paraffin sections in 63 patients with breast cancer.	Formaldehyde	84-92	estrogen receptor 1	Homo sapiens	32-49
2468075-1	1989	Immunocytochemical staining for estrogen receptor (ER) was examined in conventional formalin-fixed paraffin sections in 63 patients with breast cancer.	Formaldehyde	84-92	estrogen receptor 1	Homo sapiens	51-53
2468075-3	1989	The ER stainability in formalin-fixed paraffin sections was compared with the levels of ER measuring dextran-coated charcoal (DCC) method, and with the stainability of ER in frozen sections.	Formaldehyde	23-31	estrogen receptor 1	Homo sapiens	4-6
2480629-4	1989	The NCA epitope recognized by MAb 47D10 is well preserved in formalin-fixed and paraffin-embedded tissues.	Formaldehyde	61-69	CEA cell adhesion molecule 4	Homo sapiens	4-7
2554480-1	1989	Monoclonal antibody KH2 (IgM) reactive with lactosyl ceramide and neolactotetraosyl ceramide was applied for the first time to the staining of human cancerous and noncancerous tissues which were fixed with formalin and embedded in paraffin.	Formaldehyde	206-214	potassium voltage-gated channel modifier subfamily G member 1	Homo sapiens	20-23
2554480-7	1989	These data suggest that the monoclonal antibody KH2 may be useful in the immunohistologic diagnosis of formalin-fixed human cancerous tissues.	Formaldehyde	103-111	potassium voltage-gated channel modifier subfamily G member 1	Homo sapiens	48-51
2922380-0	1989	[Immunohistochemical demonstration of HIV-p24 antigen in formalin fixed and paraffin embedded brain and spinal cord tissue].	Formaldehyde	57-65	transmembrane p24 trafficking protein 2	Homo sapiens	42-45
2565624-2	1989	Our results demonstrate that the epitopes unique to proinsulin and insulin can be detected with the respective monoclonal antibodies using the protein A-gold technique after routine formaldehyde fixation and paraffin embedding of the tissues.	Formaldehyde	182-194	insulin	Homo sapiens	52-62
2565624-2	1989	Our results demonstrate that the epitopes unique to proinsulin and insulin can be detected with the respective monoclonal antibodies using the protein A-gold technique after routine formaldehyde fixation and paraffin embedding of the tissues.	Formaldehyde	182-194	insulin	Homo sapiens	55-62
2846572-5	1988	Reductive methylation of SP-A with H2CO and NaCNBH3 yielded forms of SP-A with markedly reduced receptor binding activity that also exhibited significantly reduced capacity to inhibit lipid secretion.	Formaldehyde	35-39	surfactant protein A1	Rattus norvegicus	25-29
2975995-4	1988	Atrial natriuretic factor caused a significant increase in sodium excretion (UNaV) [+56%], urinary flow rate (V) [+17%] and free water clearance (CH2O) [+23%]; creatinine clearance (Ccr) did not change.	Formaldehyde	146-150	natriuretic peptide A	Homo sapiens	0-25
2975995-5	1988	Arginine vasopressin reduced V (-58%) and CH2O (-68%) but did not alter UNaV or Ccr.	Formaldehyde	42-46	arginine vasopressin	Homo sapiens	0-20
3199797-5	1988	Under conditions of this assay, the ferrous form of myoglobin and H2O2 produced approximately three times the amount of formaldehyde from dimethylsulfoxide than ferric myoglobin (metmyoglobin) and H2O2.	Formaldehyde	120-132	myoglobin	Homo sapiens	52-61
3264193-4	1988	In a concentration-dependent manner, ATA also inhibits ristocetin-induced, vWF-mediated platelet clumping in both fresh and formaldehyde-fixed platelet suspensions.	Formaldehyde	124-136	von Willebrand factor	Homo sapiens	75-78
2846572-5	1988	Reductive methylation of SP-A with H2CO and NaCNBH3 yielded forms of SP-A with markedly reduced receptor binding activity that also exhibited significantly reduced capacity to inhibit lipid secretion.	Formaldehyde	35-39	surfactant protein A1	Rattus norvegicus	69-73
2903446-3	1988	We describe a method for the immunohistochemical detection of overexpression of neu protein on formalin-fixed paraffin-embedded tissue, with the use of two different monoclonal antibodies.	Formaldehyde	95-103	erb-b2 receptor tyrosine kinase 2	Homo sapiens	80-83
3063612-3	1988	This communication demonstrates that dramatic differences in the electrophoretic mobility of the yeast GCN2 transcript are observed when size fractionation on formaldehyde gels is compared to fractionation of glyoxalated RNA.	Formaldehyde	159-171	serine/threonine-protein kinase GCN2	Saccharomyces cerevisiae S288C	103-107
2847791-0	1988	A receptor for formaldehyde-treated serum albumin on human placental brush-border membrane.	Formaldehyde	15-27	albumin	Homo sapiens	36-49
2847791-1	1988	Formaldehyde-treated serum albumin (f-Alb) is known to be taken up and degraded by sinusoidal liver cells via receptor-mediated endocytosis.	Formaldehyde	0-12	albumin	Homo sapiens	21-34
2847791-1	1988	Formaldehyde-treated serum albumin (f-Alb) is known to be taken up and degraded by sinusoidal liver cells via receptor-mediated endocytosis.	Formaldehyde	0-12	albumin	Homo sapiens	38-41
3052807-2	1988	1C5 can be used for the staining of routine formalin-fixed and paraffin-embedded tissue sections.	Formaldehyde	44-52	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta	Homo sapiens	0-3
3130090-8	1988	Under conditions that block assembly, the amount of radiolabeled cyanate or formaldehyde incorporated by these reactions in the absence of HCO3-/CO2 was approximately four carbamoyl or five methyl groups in a ratio of approximately 1.7 alpha chain/beta chain.	Formaldehyde	76-88	Fc gamma receptor and transporter	Homo sapiens	236-247
3053056-1	1988	By means of in situ hybridization using biotinylated oncogene probes and the immunohistochemical reaction of avidin-biotin complex-alkaline phosphatase with substrate, we investigated expression of c-myc oncogene in the formalin-fixed, paraffin-embedded tissue sections from seven patients with squamous cell carcinoma (six cases) and small cell carcinoma (one case) of primary lung origin.	Formaldehyde	220-228	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	198-203
2903166-5	1988	By extracting the UV-irradiated quiescent cells with Triton X-100 and fixing with formaldehyde, it was possible to demonstrate by indirect immunofluorescence rapid changes in the cyclin/PCNA population after irradiation, a small proportion (5-10%) of which is tightly associated to the nucleus as determined by high salt extraction.	Formaldehyde	82-94	proliferating cell nuclear antigen	Homo sapiens	179-185
2903166-5	1988	By extracting the UV-irradiated quiescent cells with Triton X-100 and fixing with formaldehyde, it was possible to demonstrate by indirect immunofluorescence rapid changes in the cyclin/PCNA population after irradiation, a small proportion (5-10%) of which is tightly associated to the nucleus as determined by high salt extraction.	Formaldehyde	82-94	proliferating cell nuclear antigen	Homo sapiens	186-190
3222256-0	1988	Immunophenotypic diagnosis of leiomyosarcomas and rhabdomyosarcomas with monoclonal antibodies to muscle-specific actin and desmin in formalin-fixed tissue.	Formaldehyde	134-142	desmin	Homo sapiens	124-130
2841371-0	1988	Differential sensitivity of the microtubule-associated protein, tau, in Alzheimer"s disease tissue to formalin fixation.	Formaldehyde	102-110	microtubule associated protein tau	Homo sapiens	64-67
2841371-1	1988	Immunohistochemistry of formalin-fixed human Alzheimer"s disease (AD) tissue using an anti-tau antibody (Tau-1) reveals staining of neurofibrillary tangles (NFTs) and neuritic plaques (NPs), whereas normal axonal staining is less apparent.	Formaldehyde	24-32	microtubule associated protein tau	Homo sapiens	91-94
2841371-2	1988	In this study, we used a combined biochemical and histochemical approach to assess effects of formalin on immunoreactivity of AD tau.	Formaldehyde	94-102	microtubule associated protein tau	Homo sapiens	129-132
2841371-4	1988	A progressive decrease in Tau-1 immunoreactivity of the tau bands on a Western blot was observed with increasing times of formalin fixation.	Formaldehyde	122-130	microtubule associated protein tau	Homo sapiens	26-29
2841371-4	1988	A progressive decrease in Tau-1 immunoreactivity of the tau bands on a Western blot was observed with increasing times of formalin fixation.	Formaldehyde	122-130	microtubule associated protein tau	Homo sapiens	56-59
2841371-9	1988	These results indicate that axonal form(s) of tau are more sensitive to formalin fixation than pathology-associated tau.	Formaldehyde	72-80	microtubule associated protein tau	Homo sapiens	46-49
2839394-1	1988	The presence of cancer antigen CA125 has been assessed immunohistologically in formalin-fixed tumor tissue and immunoradiometrically in serum from 41 women with residual epithelial ovarian carcinoma after diagnostic laparotomy.	Formaldehyde	79-87	mucin 16, cell surface associated	Homo sapiens	31-36
2973150-7	1988	In the presence of fibrinogen, washed platelets were aggregated by SJAMP but formaldehyde-fixed platelets were not.	Formaldehyde	77-89	fibrinogen beta chain	Homo sapiens	19-29
2836318-10	1988	Using an immunoperoxidase technique on formalin-fixed, deparaffinized liver sections, we showed that DU-PAN-2 MAb reacted heterogeneously with bile-duct epithelium but never stained hepatocytes or hepatoma cells.	Formaldehyde	39-47	poly(A) specific ribonuclease subunit PAN2	Homo sapiens	104-109
3258730-2	1988	This report describes an improved technique for sensitive and specific localization of terminal deoxynucleotidyl transferase (TdT) in routinely processed paraffin-embedded, formalin-fixed tissue sections using DNAse pretreatment and the avidin-biotin complex (ABC) technique.	Formaldehyde	173-181	DNA nucleotidylexotransferase	Homo sapiens	87-124
3258730-2	1988	This report describes an improved technique for sensitive and specific localization of terminal deoxynucleotidyl transferase (TdT) in routinely processed paraffin-embedded, formalin-fixed tissue sections using DNAse pretreatment and the avidin-biotin complex (ABC) technique.	Formaldehyde	173-181	DNA nucleotidylexotransferase	Homo sapiens	126-129
3282006-4	1988	The longer the material had been fixed in formalin, the longer the incubation in proteinase required to identify BUdR-labeled nuclei.	Formaldehyde	42-50	endogenous retrovirus group K member 25	Homo sapiens	81-91
3378426-7	1988	Patients patch-test-positive to formaldehyde 0.1% and/or 0.3% tended to show more patch test reactivity to (D)MDM hydantoin than those who reacted only to 1%.	Formaldehyde	32-44	secreted LY6/PLAUR domain containing 1	Homo sapiens	110-113
3276902-4	1988	In contrast to mutational activation of ras genes, enhanced expression of p21 was observed in all tumors examined by immunohistochemical techniques with the use of Formalin-fixed paraffin-embedded tissue sections and an anti-ras p21 antibody, RAP-5.	Formaldehyde	164-172	KRAS proto-oncogene, GTPase	Rattus norvegicus	74-77
3279263-1	1988	An immunohistochemical technique using a commercially available monoclonal antibody to the estrogen receptor in formalin-fixed breast tumors is described.	Formaldehyde	112-120	estrogen receptor 1	Homo sapiens	91-108
2458833-2	1988	Polyclonal, monospecific rabbit antibody to human FN was applied on formalin-fixed, paraffin-embedded tissue sections using the peroxidase-antiperoxidase staining technique.	Formaldehyde	68-76	fibronectin 1	Homo sapiens	50-52
3196898-5	1988	VP produced a prolonged antinociception lasting at least 40 min on the tail flick (2.5 and 25 ng) and formalin (25 ng) tests, and a brief antinociception lasting less than 20 min on the tail shock (25 ng) and hot plate (25 ng) tests.	Formaldehyde	102-110	arginine vasopressin	Rattus norvegicus	0-2
2461901-6	1988	It was shown that DA7 and DC10 antibodies exhibited strong reaction in paraffin embedded tissues fixed in either methacarn or standard formalin.	Formaldehyde	135-143	myosin heavy chain 8	Homo sapiens	18-21
2461901-6	1988	It was shown that DA7 and DC10 antibodies exhibited strong reaction in paraffin embedded tissues fixed in either methacarn or standard formalin.	Formaldehyde	135-143	F-box protein 8	Homo sapiens	26-30
2841371-10	1988	In addition, a modification of AD tau in pathological structures may protect it from the effects of formalin with regard to Tau-1 antigenicity.	Formaldehyde	100-108	microtubule associated protein tau	Homo sapiens	34-37
3057152-2	1988	We have used the anti-p21ras monoclonal antibody, RAP-5, to assess the level and pattern of expression in formalin-fixed, paraffin-embedded tissue sections of both normal and malignant urothelium.	Formaldehyde	106-114	HRas proto-oncogene, GTPase	Homo sapiens	22-28
2456979-1	1988	Immunoreactivity for S-100 protein, typically a marker for malignant melanoma and neural-derived tumors, was observed in neoplastic cells of 57 of 68 cases (84%) of formalin-fixed, paraffin-embedded primary and/or metastatic carcinoma of the breast of various histologic types.	Formaldehyde	165-173	S100 calcium binding protein A1	Homo sapiens	21-26
3141327-0	1988	Inductions of ornithine decarboxylase and DNA synthesis in rat stomach mucosa by formaldehyde.	Formaldehyde	81-93	ornithine decarboxylase 1	Rattus norvegicus	14-37
3141327-1	1988	Administration of formaldehyde at doses of 11 to 110 mg/kg body weight by gastric intubation to male F344 rats induced up to 100-fold increase in ornithine decarboxylase activity with a maximum after 16 hr and up to 49-fold increase in DNA synthesis with a maximum after 16 hr in the pyloric mucosa of the stomach.	Formaldehyde	18-30	ornithine decarboxylase 1	Rattus norvegicus	146-169
2456020-10	1988	Among the neural tumors, Bouin"s fixation was superior to formalin, suggesting that immunoreactivity for NGF-R is affected by fixation.	Formaldehyde	58-66	nerve growth factor receptor	Homo sapiens	105-110
2454748-0	1988	Mapping protein-DNA interactions in vivo with formaldehyde: evidence that histone H4 is retained on a highly transcribed gene.	Formaldehyde	46-58	histone H4	Drosophila melanogaster	74-84
2454748-1	1988	We have used formaldehyde-mediated protein-DNA crosslinking within intact cells to examine the in vivo chromatin structure of the D. melanogaster heat shock protein 70 (hsp70) genes.	Formaldehyde	13-25	Heat-shock-protein-70Ab	Drosophila melanogaster	169-174
2454748-2	1988	In agreement with previous in vitro studies, we find that the heat shock-mediated transcriptional induction of the hsp70 genes perturbs their chromatin structure, resulting in fewer protein-DNA contacts crosslinkable in vivo by formaldehyde.	Formaldehyde	228-240	Heat-shock-protein-70Ab	Drosophila melanogaster	115-120
3140232-2	1988	Uptake of 125I-labelled formaldehyde-denatured bovine serum albumin by such yolk sacs was found to be similar to that observed in yolk sacs removed directly from the mother at 17.5 days" gestation, provided that homologous serum was used as a culture medium.	Formaldehyde	24-36	albumin	Rattus norvegicus	54-67
2452652-6	1988	This fragment also competes with labeled, native vWF for binding to formalin-fixed human platelets, with an IC50 of 12.5 micrograms/mL (65 nM).	Formaldehyde	68-76	von Willebrand factor	Homo sapiens	49-52
2896687-5	1988	The formaldehyde concentration in the synthetic urine was c. 90 micrograms ml-1 or more during tests.	Formaldehyde	4-16	interleukin 17F	Homo sapiens	75-79
3370247-1	1988	A form of cytochrome P-450 (P-450PB) with a molecular weight of 53.5-54.0 kD possessing a high benzphetamine-N-demethylase activity (100-120 nmol formaldehyde/min/nmol cytochrome) was isolated from liver microsomes of phenobarbital-induced C57Bl/6 mice.	Formaldehyde	146-158	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	10-26
3146857-1	1988	The distribution pattern of fibronectin in the human placenta has been studied using the indirect immunoperoxidase (PAP) technique on formalin fixed paraffin embedded tissue samples.	Formaldehyde	134-142	fibronectin 1	Homo sapiens	28-39
3126814-1	1988	Reductive methylation of bovine brain derived acidic fibroblast growth factor (aFGF) with formaldehyde and sodium cyanoborohydride reduces its capacity to stimulate mitogenesis in Balb/C 3T3 cells, and this correlates with the modification of less than 3 of its 12 lysine residues.	Formaldehyde	90-102	fibroblast growth factor 1	Mus musculus	46-77
3126814-1	1988	Reductive methylation of bovine brain derived acidic fibroblast growth factor (aFGF) with formaldehyde and sodium cyanoborohydride reduces its capacity to stimulate mitogenesis in Balb/C 3T3 cells, and this correlates with the modification of less than 3 of its 12 lysine residues.	Formaldehyde	90-102	fibroblast growth factor 1	Bos taurus	79-83
2827535-4	1988	In addition to the popularly used anti-Leu-M1 (CD15), the panel included the recently produced Ber-H2 (CD30) antibody, which detects a formalin-resistant epitope of the Ki-1 antigen.	Formaldehyde	135-143	TNF receptor superfamily member 8	Homo sapiens	103-107
3276207-10	1988	The HECA-452 antigen is preserved in paraffin sections of sublimate formaldehyde- and also routinely formalin-fixed tissues.	Formaldehyde	68-80	hdc homolog, cell cycle regulator	Homo sapiens	4-8
3276207-10	1988	The HECA-452 antigen is preserved in paraffin sections of sublimate formaldehyde- and also routinely formalin-fixed tissues.	Formaldehyde	101-109	hdc homolog, cell cycle regulator	Homo sapiens	4-8
2827535-4	1988	In addition to the popularly used anti-Leu-M1 (CD15), the panel included the recently produced Ber-H2 (CD30) antibody, which detects a formalin-resistant epitope of the Ki-1 antigen.	Formaldehyde	135-143	TNF receptor superfamily member 8	Homo sapiens	169-181
2465010-5	1988	In formalin-fixed tissue basal cells stained exclusively with Z622, predominantly with PKE and RCK 102, and to lesser degree with MCA 144 and CAM 5.2.	Formaldehyde	3-11	mitogen-activated protein kinase kinase kinase 19	Homo sapiens	95-98
3128918-4	1988	However, VIE-G 4, a monoclonal antibody selective for glycophorin A, produced a strong reaction with erythroid cells in formalin fixed sections.	Formaldehyde	120-128	glycophorin A (MNS blood group)	Homo sapiens	54-67
3179032-6	1988	By paired staining for L1 and S-100 protein, macrophages and DC of the interdigitating or Langerhans type can be visualized simultaneously in routine formalin-fixed paraffin sections.	Formaldehyde	150-158	immunoglobulin kappa variable 1-16	Homo sapiens	23-35
3266335-10	1988	L26 offers the distinct advantage of working well in both B5 and formalin-fixed tissues and seemingly not marking epithelial neoplasms.	Formaldehyde	65-73	ribosomal protein L26	Homo sapiens	0-3
3335049-8	1988	Bovine liver catalase, a heme-containing cytochrome, readily transformed hydrazine/formaldehyde to a methylating agent.	Formaldehyde	83-95	catalase	Bos taurus	13-21
3335049-9	1988	The data support formation of formaldehyde hydrazone as the condensation product of hydrazine and formaldehyde which is rapidly transformed in various liver cell fractions, perhaps by catalase and/or catalase-like enzymes, to a methylating agent.	Formaldehyde	30-42	catalase	Bos taurus	184-192
3335049-9	1988	The data support formation of formaldehyde hydrazone as the condensation product of hydrazine and formaldehyde which is rapidly transformed in various liver cell fractions, perhaps by catalase and/or catalase-like enzymes, to a methylating agent.	Formaldehyde	30-42	catalase	Bos taurus	200-208
3261278-3	1988	The number of mast cells in the spleen, approximately 60% of which were formalin-resistant and were assumed as connective tissue type mast cells (CTMC), increased 3-fold by IL-3 treatment.	Formaldehyde	72-80	interleukin 3	Mus musculus	173-177
3322020-6	1987	The authors recently investigated a monoclonal antibody (L26) that demonstrates excellent specificity and sensitivity for B lymphocytes, and tumors derived from them, in formalin- and B5-fixed, paraffin-embedded tissue.	Formaldehyde	170-178	ribosomal protein L26	Homo sapiens	57-60
2843331-2	1988	In this paper, formalin fixed tissue sections of the human colonic cancer and adenoma were tested by indirect immunofluorescence using monoclonal antibody Hb3.	Formaldehyde	15-23	keratin 83	Homo sapiens	155-158
3123439-6	1987	These results and previous findings that stomach-tumor promoters such as NaCl, taurocholate, glyoxal, K2S2O5 and formaldehyde induced ODC and DNA synthesis in the pyloric mucosa of the stomach of F344 rats suggest that the inductions of ODC and DNA synthesis in the glandular stomach mucosa are markers of promotive activities of complete carcinogens and tumor promoters in the glandular stomach.	Formaldehyde	113-125	ornithine decarboxylase 1	Rattus norvegicus	134-137
3318757-2	1987	To gain a better understanding of the role these oncogenes may play in malignant transformation, we evaluated the levels of a ras gene protein product (p21) in formaldehyde-fixed, paraffin-embedded specimens of normal human colonic mucosa, hyperplastic polyps, tubular adenomas, villous adenomas, and epithelium from a patient with ulcerative colitis.	Formaldehyde	160-172	H3 histone pseudogene 16	Homo sapiens	152-155
2445810-0	1987	Formaldehyde sensitivity of a GFAP epitope, removed by extraction of the cytoskeleton with high salt.	Formaldehyde	0-12	glial fibrillary acidic protein	Homo sapiens	30-34
2445810-2	1987	When acetone-extracted whole cells or cytoskeletons, made by extracting with Triton in stabilizing buffer (Tsb), are fixed with formaldehyde, binding of the MAB Tp-GFAP1 to GFAP is abolished or greatly reduced.	Formaldehyde	128-140	glial fibrillary acidic protein	Homo sapiens	164-168
3123439-6	1987	These results and previous findings that stomach-tumor promoters such as NaCl, taurocholate, glyoxal, K2S2O5 and formaldehyde induced ODC and DNA synthesis in the pyloric mucosa of the stomach of F344 rats suggest that the inductions of ODC and DNA synthesis in the glandular stomach mucosa are markers of promotive activities of complete carcinogens and tumor promoters in the glandular stomach.	Formaldehyde	113-125	ornithine decarboxylase 1	Rattus norvegicus	237-240
2448092-4	1987	Digestion of DNA in formaldehyde-fixed chromatin by DNase 1 was quantitated by measuring Hoechst 33258 (H33258) fluorescence of mononuclear cells.	Formaldehyde	20-32	deoxyribonuclease 1	Homo sapiens	52-59
3430480-2	1987	The immunogold silver staining (IGSS) technique was used to investigate the distribution of C1q, C3d, C4, C6 and C9 within the spiral arteries of formalin-fixed normal pregnancy hysterectomy specimens ranging in gestational age from 4 to 40 weeks.	Formaldehyde	146-154	complement C1q A chain	Homo sapiens	92-95
2449161-0	1987	Molecular consequences of two formaldehyde-induced mutations in the alcohol dehydrogenase gene of Drosophila melanogaster.	Formaldehyde	30-42	Alcohol dehydrogenase	Drosophila melanogaster	68-89
2449161-1	1987	Adhfn23 and Adhfn24 are two formaldehyde-induced, homozygous-viable, alcohol dehydrogenase-null mutants that bear lesions in the gene that codes for the alcohol dehydrogenase (ADH; EC 1.1.1.1) of Drosophila melanogaster.	Formaldehyde	28-40	Alcohol dehydrogenase	Drosophila melanogaster	69-90
2443000-6	1987	The antigenicity of vimentin was found to be preserved in all alcohol-fixed specimens and in 63% of formalin-fixed tissues.	Formaldehyde	100-108	vimentin	Homo sapiens	20-28
3623553-2	1987	The expression of PLAP was examined with a polyclonal antibody and the immunoperoxidase technique in formalin-fixed, paraffin-embedded sections of 37 germ cell neoplasms and 483 somatic tumors.	Formaldehyde	101-109	alkaline phosphatase, germ cell	Homo sapiens	18-22
3440754-1	1987	Immunocytochemical studies with a monoclonal antibody (MAb-HL3), which recognises a major isozyme of human hepatic cytochrome P-450, have demonstrated this cytochrome in both cryostat and formalin-fixed paraffin-embedded sections of normal human adult liver.	Formaldehyde	188-196	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	115-131
3305369-3	1987	Recent work in our laboratory has demonstrated the selective depletion of a surface glycoprotein of 110,000 Mr (GP110) from LJP neutrophils by using surface labeling with [14C]formaldehyde and autofluorography.	Formaldehyde	176-188	ADRM1 26S proteasome ubiquitin receptor	Homo sapiens	112-117
3454079-0	1987	Detection of histidine decarboxylase (HDC) in paraffin sections of formalin fixed rat stomach using avidin-biotin-peroxidase-complex method.	Formaldehyde	67-75	histidine decarboxylase	Rattus norvegicus	13-36
3629625-0	1987	Binding of formaldehyde to human and rat nasal mucus and bovine serum albumin.	Formaldehyde	11-23	albumin	Rattus norvegicus	64-77
3629625-4	1987	[14C]Formaldehyde was incubated with reconstituted preparations of human and rat nasal mucus or bovine serum albumin.	Formaldehyde	5-17	albumin	Rattus norvegicus	103-116
3454079-0	1987	Detection of histidine decarboxylase (HDC) in paraffin sections of formalin fixed rat stomach using avidin-biotin-peroxidase-complex method.	Formaldehyde	67-75	histidine decarboxylase	Rattus norvegicus	38-41
3038958-5	1987	Moreover, IIB vWF caused agglutination of formalin-fixed platelets that was blocked only by the anti-GPIb antibody, suggesting that the binding of vWF to GPIb, even in the absence of ristocetin, results in platelet-platelet interaction that is followed by exposure of the GPIIb/IIIa receptors for adhesive proteins.	Formaldehyde	42-50	von Willebrand factor	Homo sapiens	14-17
3038958-5	1987	Moreover, IIB vWF caused agglutination of formalin-fixed platelets that was blocked only by the anti-GPIb antibody, suggesting that the binding of vWF to GPIb, even in the absence of ristocetin, results in platelet-platelet interaction that is followed by exposure of the GPIIb/IIIa receptors for adhesive proteins.	Formaldehyde	42-50	von Willebrand factor	Homo sapiens	147-150
3613527-1	1987	MAM-6 antigen is detectable in a large variety of formalin fixed and paraffin embedded normal and neoplastic tissues throughout the body with some exceptions.	Formaldehyde	50-58	mucin 1, cell surface associated	Homo sapiens	0-5
2438809-1	1987	Glutathione (GSH) is required for the oxidation of formaldehyde (HCHO) to formate catalyzed by formaldehyde dehydrogenase (FDH).	Formaldehyde	51-63	alcohol dehydrogenase 5 (class III), chi polypeptide	Rattus norvegicus	95-121
2438809-1	1987	Glutathione (GSH) is required for the oxidation of formaldehyde (HCHO) to formate catalyzed by formaldehyde dehydrogenase (FDH).	Formaldehyde	51-63	alcohol dehydrogenase 5 (class III), chi polypeptide	Rattus norvegicus	123-126
3571287-11	1987	The 4 S GR was covalently cross-linked with the purified RNA (termed PIVB RNA) using formaldehyde.	Formaldehyde	85-97	nuclear receptor subfamily 3, group C, member 1	Mus musculus	8-10
2880658-1	1987	Stage-specific embryonic antigen-1 (SSEA-1) was localized on paraffin embedded, formalin fixed specimens of human renal tumors by immunoperoxidase staining using a monoclonal antibody.	Formaldehyde	80-88	fucosyltransferase 4	Homo sapiens	0-42
3591661-3	1987	The slope of the calibration line (absorbance at 412 nm vs. formaldehyde concentration) is -0.350 A.U./ug CH2O/mL (correlation coefficient: 0.9995).	Formaldehyde	60-72	CHM like Rab escort protein	Homo sapiens	106-113
2436753-3	1987	Using the indirect peroxidase-antiperoxidase method of Sternberger, optimal conditions for demonstrating PR involved brief fixation of frozen sections with formaldehyde-containing fixatives, among them picric acid-paraformaldehyde.	Formaldehyde	156-168	progesterone receptor	Homo sapiens	105-107
3497183-4	1987	4-micron cryosections of formaldehyde-fixed tooth germs showed positive immunocytochemical staining for osteocalcin in dentin and odontoblasts.	Formaldehyde	25-37	osteocalcin	Oryctolagus cuniculus	104-115
3593051-3	1987	Unselected sera from 113 chronic hemodialysis patients (CHP) and 200 control subjects were tested for IgG antibodies to formaldehyde-treated human serum albumin (HSA).	Formaldehyde	120-132	albumin	Homo sapiens	147-160
3593593-0	1987	Effects of various basic compounds on the degradation of formaldehyde-treated 125I-labeled bovine serum albumin in mouse liver lysosomes.	Formaldehyde	57-69	albumin	Mus musculus	98-111
3593593-1	1987	The effect of various basic compounds on degradation of formaldehyde-treated 125I-bovine serum albumin (denatured 125I-BSA) in livers of mice was studied in detail.	Formaldehyde	56-68	albumin	Mus musculus	89-102
3548317-1	1987	The authors investigated formalin-fixed, paraffin-embedded human tissues for the presence of corticotrophin-releasing hormone (CRH) using the avidin-biotin-peroxidase technic.	Formaldehyde	25-33	corticotropin releasing hormone	Homo sapiens	93-125
3548317-1	1987	The authors investigated formalin-fixed, paraffin-embedded human tissues for the presence of corticotrophin-releasing hormone (CRH) using the avidin-biotin-peroxidase technic.	Formaldehyde	25-33	corticotropin releasing hormone	Homo sapiens	127-130
3308931-2	1987	When cells were fixed with 3% formaldehyde for 15 min prior to lysis with 0.5% Triton X-100, spindle fibres in mitotic cells were fluorescent and a diffuse cytoplasmic localization of calmodulin was observed in resting cells.	Formaldehyde	30-42	calmodulin 1	Homo sapiens	184-194
3493809-6	1987	The von Willebrand factor-coated latex beads of 2.02 micron diameter, in contrast to the smaller size, induced rapid agglutination of formalin-fixed human platelets in the absence of any other aggregating agent.	Formaldehyde	134-142	von Willebrand factor	Homo sapiens	4-25
3494060-2	1987	Demonstration of IL 1 activity was based on the ability of TNF-treated FS-4 cells, subsequently fixed with formaldehyde, to stimulate thymocyte proliferation in the presence of phytohemagglutinin.	Formaldehyde	107-119	interleukin 1 beta	Homo sapiens	17-21
3494060-2	1987	Demonstration of IL 1 activity was based on the ability of TNF-treated FS-4 cells, subsequently fixed with formaldehyde, to stimulate thymocyte proliferation in the presence of phytohemagglutinin.	Formaldehyde	107-119	tumor necrosis factor	Homo sapiens	59-62
3494060-3	1987	Incubation of FS-4 cells with the optimal dose of TNF (10 ng/ml) resulted in a marked increase in [3H] thymidine uptake by thymocytes co-cultured with formaldehyde-fixed FS-4 cells.	Formaldehyde	151-163	tumor necrosis factor	Homo sapiens	50-53
3300723-4	1987	Prefixation of C. albicans with formaldehyde decreased binding of fibrinogen, and pretreatment with mercaptoethanol and pronase abolished it.	Formaldehyde	32-44	fibrinogen beta chain	Homo sapiens	66-76
3026257-6	1987	Identification of NSE as assessed by immunohistochemical procedure employing the ABC method on formalin-fixed paraffin-embedded tissue sections in lung cancer cases of each histological type, showed that some materials from non-SCLC cases were positively stained despite the presence of normal serum NSE levels, and did not always parallel the serum levels.	Formaldehyde	95-103	enolase 2	Homo sapiens	18-21
2433953-2	1987	The expression of carcinoembryonic antigen (CEA) and related antigens in formalin-fixed paraffin-embedded tissues of 200 primary thyroid carcinomas and 22 nonmalignant thyroid lesions was studied immunocytochemically by using three monoclonal antibodies recognizing different epitopes on CEA and related antigens.	Formaldehyde	73-81	CEA cell adhesion molecule 3	Homo sapiens	18-42
2433953-2	1987	The expression of carcinoembryonic antigen (CEA) and related antigens in formalin-fixed paraffin-embedded tissues of 200 primary thyroid carcinomas and 22 nonmalignant thyroid lesions was studied immunocytochemically by using three monoclonal antibodies recognizing different epitopes on CEA and related antigens.	Formaldehyde	73-81	CEA cell adhesion molecule 3	Homo sapiens	44-47
3689591-4	1987	The staining for myoglobin with the poly- and monoclonal antibody used was positive in both formaldehyde- and ethanol-fixed skeletal and cardiac control muscle.	Formaldehyde	92-104	myoglobin	Homo sapiens	17-26
3817736-10	1987	The antithrombin III plus heparin group showed slightly better results than the antithrombin III group in Ucr/Pcr ratio, creatinine clearance and CH2O.	Formaldehyde	146-150	serpin family C member 1	Homo sapiens	4-20
3108204-1	1987	A formalin-calcium fixation method of preparing cryosections is described, which allows demonstration of Langerhans" cells by S100 antigen staining on frozen sections.	Formaldehyde	2-10	S100 calcium binding protein A1	Homo sapiens	126-130
3610670-5	1987	AlP activity in tissue sections from bones fixed in 10% formalin, 2% glutaraldehyde, or formal-calcium, however, was markedly inhibited after 3-7 days and was no longer detectable after 14 days of fixation.	Formaldehyde	56-64	ATHS	Homo sapiens	0-3
3569638-3	1987	Vitellogenin mRNA was isolated from estrogenized chick liver, fractionated by electrophoresis using formaldehyde/agarose gels and blot transferred to nitrocellulose paper.	Formaldehyde	100-112	vitellogenin 2	Gallus gallus	0-12
3610670-6	1987	Moreover, AlP activity was diminished in tissue sections from bones fixed in 70% ethanol or 10% formalin and subsequently demineralized in 10% EDTA (pH 7) for 2 days, and the activity was completely abolished in tissue sections from bones subsequently demineralized in 5% formic acid: 20% sodium citrate (1:1, pH 4.2) for 2 days.	Formaldehyde	96-104	ATHS	Homo sapiens	10-13
3319920-0	1987	Estrogen receptor localization in formalin-fixed, paraffin-embedded endometrium and endometriotic tissues.	Formaldehyde	34-42	estrogen receptor 1	Homo sapiens	0-17
3121543-5	1987	Therefore, precise localization of hEGF was obtainable only in formalin-fixed sections using the monoclonal antibody against hEGF.	Formaldehyde	63-71	epidermal growth factor	Homo sapiens	35-39
3679418-7	1987	In-vitro assays of O6-methylguanine-DNA methyltransferase (MMT) activity indicate that it is markedly inhibited by acrolein, and to a lesser extent by formaldehyde.	Formaldehyde	151-163	O-6-methylguanine-DNA methyltransferase	Homo sapiens	19-57
3679418-7	1987	In-vitro assays of O6-methylguanine-DNA methyltransferase (MMT) activity indicate that it is markedly inhibited by acrolein, and to a lesser extent by formaldehyde.	Formaldehyde	151-163	O-6-methylguanine-DNA methyltransferase	Homo sapiens	59-62
2426478-3	1986	Our analysis of fixation effects and immunohistochemical staining of polyclonal antibody to PSA indicates that the formalin fixation and paraffin embedding methods used previously did provide optimum localization of the antigen and the variations in the intensity of PSA staining could not be attributed to the methodology.	Formaldehyde	115-123	kallikrein related peptidase 3	Homo sapiens	92-95
3695493-1	1987	Androgen receptor-acceptor complexes in nuclei from rat ventral prostates were cross-linked in situ with formaldehyde and partially purified using affinity chromatography.	Formaldehyde	105-117	androgen receptor	Rattus norvegicus	0-17
2819806-0	1987	Energy yields for hydrogen cyanide and formaldehyde syntheses: the HCN and amino acid concentrations in the primitive ocean.	Formaldehyde	39-51	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	67-70
3827870-2	1986	Formaldehyde can be oxidized primarily by two different enzymes, the low-Km mitochondrial aldehyde dehydrogenase and the cytosolic GSH-dependent formaldehyde dehydrogenase.	Formaldehyde	0-12	aldehyde dehydrogenase 2 family member	Rattus norvegicus	76-112
3827870-10	1986	This increase in product formation at higher formaldehyde concentrations was much more sensitive to inhibition by diethyl maleate or cyanamide, suggesting an important contribution by mitochondrial aldehyde dehydrogenase.	Formaldehyde	45-57	aldehyde dehydrogenase 2 family member	Rattus norvegicus	184-220
3797988-6	1986	All mabs have been found suitable for immunohistochemical localization of hTTR even in formaldehyde fixed and paraffin embedded tissues.	Formaldehyde	87-99	transthyretin	Homo sapiens	74-78
3022817-6	1986	In the presence of Cl- the myeloperoxidase-catalyzed oxidation at pH 5 gave nearly the same result as did the oxidation by NaOCl, whereas in the absence of Cl- the result of the oxidation was similar to that of the horseradish peroxidase-catalyzed oxidation, except for a low yield of formaldehyde formation, which was ascribed to the decomposition of H2O2 by the catalase activity of myeloperoxidase.	Formaldehyde	285-297	myeloperoxidase	Homo sapiens	27-42
3544674-0	1986	Monoclonal antibodies to GFAP epitopes available in formaldehyde fixed tissue.	Formaldehyde	52-64	glial fibrillary acidic protein	Mus musculus	25-29
3544674-1	1986	We have recently demonstrated that one of our monoclonal antibodies (MAB"s) to glial fibrillary acidic protein (GFAP) recognizes an epitope on this molecule which is to a large degree blocked during fixation with formaldehyde or crosslinking with Dithiobis (Succinimidyl) Propionate (DTSP).	Formaldehyde	213-225	glial fibrillary acidic protein	Mus musculus	79-110
3544674-1	1986	We have recently demonstrated that one of our monoclonal antibodies (MAB"s) to glial fibrillary acidic protein (GFAP) recognizes an epitope on this molecule which is to a large degree blocked during fixation with formaldehyde or crosslinking with Dithiobis (Succinimidyl) Propionate (DTSP).	Formaldehyde	213-225	glial fibrillary acidic protein	Mus musculus	112-116
3544674-3	1986	In an attempt to produce further MAB"s capable of recognizing epitopes on the GFAP molecule available following formaldehyde fixation, we immunized BALB-C mice with cytoskeletal preparations of human glioma cells which contain GFAP where the blocking protein or proteins were crossbound by DTSP or formaldehyde to the GFAP.	Formaldehyde	112-124	glial fibrillary acidic protein	Mus musculus	78-82
3544674-4	1986	Following fusion of the spleen lymphocytes to Sp 2/0 myeloma cells we have cloned hybridomas which produce antibodies that recognize GFAP in formaldehyde fixed tissues.	Formaldehyde	141-153	glial fibrillary acidic protein	Mus musculus	133-137
3531337-0	1986	Expression of mouse beta 2-microglobulin in frozen and formaldehyde-fixed central nervous tissues: comparison of tissue behind the blood-brain barrier and tissue in a barrier-free region.	Formaldehyde	55-67	beta-2 microglobulin	Mus musculus	20-40
3643647-3	1986	In Wistar rats, inoculated with a formol-inactivated suspension of S. typhy and treated with TP2, the antibody titre increases 3.3 times at most.	Formaldehyde	34-40	transition protein 2	Rattus norvegicus	93-96
3543065-1	1986	The aspartic proteinase cathepsin D was purified from human spleen and localised in various formalin fixed paraffin embedded human tissues using the peroxidase-antiperoxidase (PAP) technique.	Formaldehyde	92-100	cathepsin D	Homo sapiens	24-35
2426478-3	1986	Our analysis of fixation effects and immunohistochemical staining of polyclonal antibody to PSA indicates that the formalin fixation and paraffin embedding methods used previously did provide optimum localization of the antigen and the variations in the intensity of PSA staining could not be attributed to the methodology.	Formaldehyde	115-123	kallikrein related peptidase 3	Homo sapiens	267-270
3942531-2	1986	Rhodopsin was identified in formaldehyde-fixed, paraffin-embedded human fetal retina, and in five retinoblastomas using monoclonal antibody (MAb) MAb-E.	Formaldehyde	28-40	rhodopsin	Homo sapiens	0-9
3734844-0	1986	Antitumor effect of formalin-fixed Toxoplasma gondii organisms on EL4 lymphoma in Toxoplasma-infected mice.	Formaldehyde	20-28	epilepsy 4	Mus musculus	66-69
3734844-1	1986	The antitumor effect of formalin-fixed Toxoplasma organisms (f-Tp) as an immunostimulant on EL4 lymphoma was examined in Toxoplasma-infected syngeneic female C57B1/6 mice.	Formaldehyde	24-32	epilepsy 4	Mus musculus	92-95
3518399-0	1986	Immunohistochemical localization of CA 125 antigen in formalin-fixed paraffin sections of ovarian tumors with the use of Pronase.	Formaldehyde	54-62	mucin 16, cell surface associated	Homo sapiens	36-42
3722547-0	1986	Influence of formaldehyde-treated soybean meal on milk production.	Formaldehyde	13-25	Weaning weight-maternal milk	Bos taurus	50-54
3007538-4	1986	Data analyzed from Scatchard plots show that prior treatment of formalin-fixed A431 cells with EF for 30 minutes results in an increase in the number of binding sites for 125I-EGF.	Formaldehyde	64-72	epidermal growth factor	Homo sapiens	176-179
3964680-2	1986	Incubation of IAP with formaldehyde and pyridine-borane produced the modified toxin in which most of the free amino groups were dimethylated.	Formaldehyde	23-35	islet amyloid polypeptide	Homo sapiens	14-17
2419044-1	1986	In this investigation, the presence of calcitonin and calmodulin has been demonstrated in immunoperoxidase formalin-fixed, paraffin-embedded sections of lung from autopsy tissues of four patients who died as a result of complications resulting from their cystic fibrosis disease.	Formaldehyde	107-115	calmodulin 1	Homo sapiens	54-64
2939228-1	1986	The Wachstein-Meisel ATPase reaction can be used in formalin-fixed, postmortem material to demonstrate the microvasculature in the human myocardium.	Formaldehyde	52-60	dynein axonemal heavy chain 8	Homo sapiens	21-27
3705001-2	1986	Earlier studies of various investigators demonstrated that TSP is the endogenous platelet lectin and is responsible for the hemagglutinating activity expressed on formaldehyde-fixed thrombin-treated platelets.	Formaldehyde	163-175	thrombospondin 1	Homo sapiens	59-62
3705001-2	1986	Earlier studies of various investigators demonstrated that TSP is the endogenous platelet lectin and is responsible for the hemagglutinating activity expressed on formaldehyde-fixed thrombin-treated platelets.	Formaldehyde	163-175	coagulation factor II, thrombin	Homo sapiens	182-190
3729411-4	1986	At substrate concentrations of 0.5 and 5 mM, rates of NDMA metabolism to formaldehyde catalyzed by cytochrome P-450j were at least 15-fold greater than the rates obtained with any of the other purified isozymes.	Formaldehyde	73-85	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	99-116
3086321-10	1986	Interestingly, immunofluorescence studies indicate that only two monoclonal antibody groups (C and D) are able to decorate membrane-bound galactosyltransferase (Golgi-associated) in formalin-fixed, methanol-, or detergent-permeabilized cells.	Formaldehyde	182-190	N-acetyllactosaminide alpha-1,3-galactosyltransferase	Bos taurus	138-159
3743603-6	1986	The data showed that cells derived from aggregates of cultures treated with formaldehyde or acetaldehyde followed by exposure to TPA possessed a considerably higher ability to form colonies in soft agar than untreated control cells.	Formaldehyde	76-88	plasminogen activator, tissue type	Rattus norvegicus	129-132
3746349-1	1986	Copper-zinc superoxide dismutase (CuZn-SOD) has been localized in formalin-fixed, paraffin-embedded sections of both canine and rat brains.	Formaldehyde	66-74	superoxide dismutase 1	Rattus norvegicus	34-42
2422219-11	1986	UCHL1 is a monoclonal antibody that identifies T cells in formalin fixed paraffin embedded tissues, and should prove useful for diagnosing T cell lymphomas, especially when only formalin fixed tissue is available for diagnosis.	Formaldehyde	58-66	ubiquitin C-terminal hydrolase L1	Homo sapiens	0-5
2422219-11	1986	UCHL1 is a monoclonal antibody that identifies T cells in formalin fixed paraffin embedded tissues, and should prove useful for diagnosing T cell lymphomas, especially when only formalin fixed tissue is available for diagnosis.	Formaldehyde	178-186	ubiquitin C-terminal hydrolase L1	Homo sapiens	0-5
2425248-4	1986	In this highly sensitive system, contrary to direct immunofluorescence previously performed using formalin-fixed lymphoid tissue, the anti-IgA1 69.114 reacted with some of the IgA2 plasma cells, the anti-IgA2 DLDB7 reacted with some of the IgA1 plasma cells and the anti-IgA2 16.512 dimly reacted with all IgM plasma cells.	Formaldehyde	98-106	immunoglobulin heavy constant alpha 1	Homo sapiens	139-143
2418882-1	1986	The LDL receptor synthesis of human skin fibroblasts in the presence of the specific calmodulin antagonists trifluoperazine, condensation product of N-methyl-p-methoxyphenethylamine with formaldehyde (compound 48/80) and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide) (W-7) was studied.	Formaldehyde	187-199	low density lipoprotein receptor	Homo sapiens	4-16
2418882-1	1986	The LDL receptor synthesis of human skin fibroblasts in the presence of the specific calmodulin antagonists trifluoperazine, condensation product of N-methyl-p-methoxyphenethylamine with formaldehyde (compound 48/80) and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide) (W-7) was studied.	Formaldehyde	187-199	calmodulin 1	Homo sapiens	85-95
3002592-3	1986	Polyclonal (rabbit, monospecific) and monoclonal (mouse) antibodies anti-CEA were applied to formalin-fixed, paraffin-embedded tissue sections using an indirect (PAP) immunoperoxidase method.	Formaldehyde	93-101	CEA cell adhesion molecule 3	Homo sapiens	73-76
2430706-1	1986	NKI/C-3 and NKI/black-13 are monoclonal antibodies recognizing different epitopes on a melanoma-associated antigen that is preserved after fixation in formalin and embedding in paraffin in virtually all melanoma tissues.	Formaldehyde	151-159	ankyrin repeat domain 36B	Homo sapiens	87-114
2435633-12	1986	Von Willebrand factor activity, expressed as its ability to induce platelet aggregation in the presence of the antibiotic Ristocetin, can be carried out using normal formalin fixed platelets, either with aggregometer or visual methods (glass slide test or tubes test and microtritation plate).	Formaldehyde	166-174	von Willebrand factor	Homo sapiens	0-21
3941010-0	1986	Human antibodies against formaldehyde-human serum albumin conjugates or human serum albumin in individuals exposed to formaldehyde.	Formaldehyde	25-37	albumin	Homo sapiens	44-57
3941010-0	1986	Human antibodies against formaldehyde-human serum albumin conjugates or human serum albumin in individuals exposed to formaldehyde.	Formaldehyde	118-130	albumin	Homo sapiens	44-57
3941010-0	1986	Human antibodies against formaldehyde-human serum albumin conjugates or human serum albumin in individuals exposed to formaldehyde.	Formaldehyde	118-130	albumin	Homo sapiens	78-91
3937555-1	1985	Purified bovine rhodopsin was reductively methylated with formaldehyde and pyridine/borane with the incorporation of approximately 20 methyl groups in the protein.	Formaldehyde	58-70	rhodopsin	Bos taurus	16-25
3513457-1	1986	Carcinoembryonic antigen (CEA) and S 100 protein (S 100) have been demonstrated in formalin-fixed paraffin sections of eccrine and apocrine sweat glands, and tumors of the sweat glands, as well as, for comparison, in a variety of tumors deriving from epidermal and follicular structures using the peroxidase-antiperoxidase technique.	Formaldehyde	83-91	S100 calcium binding protein A1	Homo sapiens	0-56
3091418-1	1986	Isolated rat liver endothelial cells take up and degrade formaldehyde serum albumin (FSA), invertase and chondroitin sulfate (CS) efficiently.	Formaldehyde	57-69	albumin	Rattus norvegicus	70-83
3004013-1	1986	The expression of CEA and related antigens in formalin-fixed paraffin-embedded tissues of normal pancreas and different pancreatic neoplasms was studied immunocytochemically using three monoclonal antibodies (MAbs) recognizing different epitopes on CEA and related antigens.	Formaldehyde	46-54	CEA cell adhesion molecule 3	Homo sapiens	18-21
3911731-7	1985	These results show that immunohistochemical demonstration of S-100 protein and lysozyme can be successfully applied to formalin-fixed, paraffin embedded tissue after storage at room temperature for as long as 15 years.	Formaldehyde	119-127	S100 calcium binding protein A1	Homo sapiens	61-66
2415469-1	1985	The reactivity of monoclonal antibody (MAb) anti-leu 7 (HNK-1) on formalin-fixed sections of prostate tissues was determined by an immunoperoxidase assay.	Formaldehyde	66-74	beta-1,3-glucuronyltransferase 1	Homo sapiens	49-54
2415469-1	1985	The reactivity of monoclonal antibody (MAb) anti-leu 7 (HNK-1) on formalin-fixed sections of prostate tissues was determined by an immunoperoxidase assay.	Formaldehyde	66-74	beta-1,3-glucuronyltransferase 1	Homo sapiens	56-61
3003981-3	1985	The best ultracytochemical demonstration of 5"-nucleotidase and ATPase activities was achieved after fixation in buffered 2% formaldehyde prior to cytochemical incubation.	Formaldehyde	125-137	5'-nucleotidase ecto	Homo sapiens	44-59
3003981-3	1985	The best ultracytochemical demonstration of 5"-nucleotidase and ATPase activities was achieved after fixation in buffered 2% formaldehyde prior to cytochemical incubation.	Formaldehyde	125-137	dynein axonemal heavy chain 8	Homo sapiens	64-70
2417995-1	1985	The distribution of Tamm-Horsfall protein (THP) was studied in the human kidney using formalin-fixed, paraffin-embedded sections with a monoclonal antibody specific for human THP applied in conjunction with a modified dinitrophenyl hapten sandwich staining (DHSS) procedure.	Formaldehyde	86-94	uromodulin	Homo sapiens	43-46
2986665-11	1985	Of 32 formalin fixed lung tumour resection specimens 6 were cases of SCC, 25 non-SCC and 1 a chemodectoma.	Formaldehyde	6-14	serpin family B member 3	Homo sapiens	69-72
4022778-1	1985	Mouse fibroblasts labeled 1-9 h with 3H-uridine contained radioactive 45S rRNA subspecies of 13.9, 13.3, and 12.8 kb, as determined by hybrid-selection with rDNA plasmids and by electrophoresis in agarose-formaldehyde.	Formaldehyde	205-217	DNA segment, 45S	Mus musculus	70-73
4027236-3	1985	Platelets fixed with formaldehyde following activation by thrombin are agglutinated by exogenously added TSP.	Formaldehyde	21-33	coagulation factor II, thrombin	Homo sapiens	58-66
4027236-3	1985	Platelets fixed with formaldehyde following activation by thrombin are agglutinated by exogenously added TSP.	Formaldehyde	21-33	thrombospondin 1	Homo sapiens	105-108
3879812-4	1985	It was found that the Formalin-fixed Staphylococcus aureus formerly used for immunoprecipitation inhibits in vitro abl kinase activity.	Formaldehyde	22-30	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	115-118
3894498-3	1985	Copper-zinc superoxide dismutase (CuZn SOD) has been localized in formalin-fixed rat tissues.	Formaldehyde	66-74	superoxide dismutase 1	Rattus norvegicus	34-42
3929832-1	1985	Discoidal complexes of human apolipoprotein A-I-egg phosphatidylcholine-cholesterol were prepared by the sodium cholate dialysis procedure and were reacted to varying extents with the amino group reagents citraconic anhydride, diketene, and formaldehyde in the presence of sodium borohydride.	Formaldehyde	241-253	apolipoprotein A1	Homo sapiens	29-47
4004857-1	1985	It was demonstrated that perylenoyl-labeled triglyceride, rac-1,2-dioleoyl-3-[9(3-perylenoyl)nonanoyl]glycerol (PLTG), specifically stains the intracellular lipids in formalin-fixed and non-fixed cells in situ and in suspension.	Formaldehyde	167-175	Rac family small GTPase 1	Homo sapiens	58-63
2998008-7	1985	Preabsorption of the cell extract prior to immunoprecipitation with an excess of formalin-fixed Staphylococcus aureus, complexed with preimmune normal rabbit serum IgG, specifically removed the kinase phosphorylating p50.	Formaldehyde	81-89	nuclear factor kappa B subunit 1	Homo sapiens	217-220
3970916-5	1985	This blockade is due to the inhibition of glyceraldehyde-3-phosphate dehydrogenase by NAD+ depletion caused by enzymatic oxidation of formaldehyde coupled to NADH production.	Formaldehyde	134-146	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	42-82
3882581-0	1985	Biochemical characterization and cellular localization of a formalin-resistant melanoma-associated antigen reacting with monoclonal antibody NKI/C-3.	Formaldehyde	60-68	complement C3	Homo sapiens	145-148
3882581-1	1985	A monoclonal antibody (MAb NKI/C-3) produced against a purified membrane preparation of human melanoma cells reacts preferentially with sections of formaldehyde-fixed and paraffin-embedded tissues of melanoma, nevocellular nevi, carcinoids and medullary carcinomas of the thyroid.	Formaldehyde	148-160	complement C3	Homo sapiens	31-34
4000132-1	1985	Bacterial lipopolysaccharide (LPS) induces the release of tumour necrosis factor (TNF) into serum of mice previously infected with Listeria monocytogenes or immunized with formalin-killed Corynebacterium parvum.	Formaldehyde	172-180	toll-like receptor 4	Mus musculus	30-33
2992113-3	1985	Platelets in patient platelet-rich plasma or washed platelet suspensions and patient platelets treated with formalin agglutinated in the presence of markedly lower concentrations of bovine vWF than those required for normal platelets.	Formaldehyde	108-116	von Willebrand factor	Bos taurus	189-192
3985999-8	1985	It is proposed that formaldehyde produced during the N-demethylation of aminopyrine by cytochrome P-450 combines reversibly with GSH to form S-hydroxymethylglutathione which is oxidized by formaldehyde dehydrogenase to S-formylglutathione.	Formaldehyde	20-32	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	87-103
4000132-1	1985	Bacterial lipopolysaccharide (LPS) induces the release of tumour necrosis factor (TNF) into serum of mice previously infected with Listeria monocytogenes or immunized with formalin-killed Corynebacterium parvum.	Formaldehyde	172-180	tumor necrosis factor	Mus musculus	58-80
4000132-1	1985	Bacterial lipopolysaccharide (LPS) induces the release of tumour necrosis factor (TNF) into serum of mice previously infected with Listeria monocytogenes or immunized with formalin-killed Corynebacterium parvum.	Formaldehyde	172-180	tumor necrosis factor	Mus musculus	82-85
4036450-1	1985	Methionine synthase reaction may be coupled with thymidylate synthase-catalysed tritium release from [5-3H]dUMP via non-enzymatic reaction of formaldehyde with tetrahydrofolate.	Formaldehyde	142-154	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	0-19
2579631-1	1985	Monoclonal antibody ME491 identifies a cutaneous melanoma-associated antigen in formaldehyde-fixed, paraffin-embedded tissues.	Formaldehyde	80-92	CD63 molecule	Homo sapiens	20-25
2579631-1	1985	Monoclonal antibody ME491 identifies a cutaneous melanoma-associated antigen in formaldehyde-fixed, paraffin-embedded tissues.	Formaldehyde	80-92	ankyrin repeat domain 36B	Homo sapiens	49-76
2981213-3	1985	Kinetic studies of binding of 125I-labeled formaldehyde-treated serum albumin (125I-f-Alb) with the membranes of sinusoidal liver cells demonstrated the presence of specific, high-affinity, saturable membrane-bound receptors with an apparent Kd = 8 micrograms of f-Alb/ml and the optimal pH at around 8.0.	Formaldehyde	43-55	albumin	Rattus norvegicus	86-89
2981213-3	1985	Kinetic studies of binding of 125I-labeled formaldehyde-treated serum albumin (125I-f-Alb) with the membranes of sinusoidal liver cells demonstrated the presence of specific, high-affinity, saturable membrane-bound receptors with an apparent Kd = 8 micrograms of f-Alb/ml and the optimal pH at around 8.0.	Formaldehyde	43-55	albumin	Rattus norvegicus	265-268
2981214-1	1985	A membrane-associated receptor involved in a specific uptake of formaldehyde-treated serum albumin (f-Alb) was purified from rat livers by Triton X-100 solubilization of a 105,000 X g membrane preparation and affinity chromatography on an f-Alb-Sepharose column.	Formaldehyde	64-76	albumin	Rattus norvegicus	102-105
2981214-1	1985	A membrane-associated receptor involved in a specific uptake of formaldehyde-treated serum albumin (f-Alb) was purified from rat livers by Triton X-100 solubilization of a 105,000 X g membrane preparation and affinity chromatography on an f-Alb-Sepharose column.	Formaldehyde	64-76	albumin	Rattus norvegicus	241-244
2981216-2	1985	Chemically modified proteins such as acetylated low-density lipoprotein (acetyl-LDL) and formaldehyde-treated serum albumin (f-Alb) infused intravenously are known to undergo receptor-mediated endocytosis by sinusoidal liver cells, major intravascular scavenger cells in vivo.	Formaldehyde	89-101	albumin	Rattus norvegicus	127-130
2992796-9	1985	Incubation of LEC with fluorescein amine conjugates of ovalbumin or formaldehyde treated serum albumin, but not with fluoresceinated native serum albumin, results in accumulation of fluorescence specifically localized in the large perinuclear vesicles.	Formaldehyde	68-80	C-C motif chemokine ligand 16	Homo sapiens	14-17
2420320-2	1985	Alcohol-formol proved to be particularly advisable for studies on the epithelial mucins, buffered formol with cetylpyridinium chloride for the connective tissue polyanions and the fluid of Mota et al.	Formaldehyde	8-14	FRAS1 related extracellular matrix 1	Homo sapiens	189-193
3884028-4	1985	This subpressor dose of angiotensin II significantly decreased urine volume, urinary excretion of sodium, chloride and phosphate and distal delivery [(CH2O + CCl)/GFR X 100] in the absence of changes in GFR or distal fractional chloride absorption [CH2O/(CH2O + CCl)].	Formaldehyde	151-155	angiotensinogen	Homo sapiens	24-38
3884028-4	1985	This subpressor dose of angiotensin II significantly decreased urine volume, urinary excretion of sodium, chloride and phosphate and distal delivery [(CH2O + CCl)/GFR X 100] in the absence of changes in GFR or distal fractional chloride absorption [CH2O/(CH2O + CCl)].	Formaldehyde	249-253	angiotensinogen	Homo sapiens	24-38
3884028-4	1985	This subpressor dose of angiotensin II significantly decreased urine volume, urinary excretion of sodium, chloride and phosphate and distal delivery [(CH2O + CCl)/GFR X 100] in the absence of changes in GFR or distal fractional chloride absorption [CH2O/(CH2O + CCl)].	Formaldehyde	249-253	angiotensinogen	Homo sapiens	24-38
6092512-6	1984	Other modes of activation of B cells, by T cell-independent, formalin-treated staphylococci and Epstein-Barr virus, and by T cell-dependent pokeweed mitogen, also induced IL-2 receptor expression.	Formaldehyde	61-69	interleukin 2	Homo sapiens	171-175
3925619-1	1985	An immunohistochemical investigation of vimentin, an intermediate filament, was carried out on formalin fixed paraffin embedded sections of 44 malignant mesotheliomas of the pleura and 24 pulmonary adenocarcinomas, in order to assess its value in differential diagnosis.	Formaldehyde	95-103	vimentin	Homo sapiens	40-48
3880759-2	1985	Immunofluorescence staining of formaldehyde-fixed erythrocytes demonstrated that the immunoreactive myosin polypeptide is present in all cells and is localized in a punctate pattern throughout the cell.	Formaldehyde	31-43	myosin heavy chain 14	Homo sapiens	100-106
2995943-3	1985	In contrast, specific binding of the delta ligand [3H]D-Ala2,D-Leu5-enkephalin was virtually totally eliminated as a result of formaldehyde perfusion.	Formaldehyde	127-139	proenkephalin	Rattus norvegicus	68-78
2419962-6	1985	The X47 virus treated with formalin retained its hemagglutinin (HA) and neuraminidase (NA) activities but lost its cytotoxic potential.	Formaldehyde	27-35	neuraminidase 1	Homo sapiens	72-85
2419962-6	1985	The X47 virus treated with formalin retained its hemagglutinin (HA) and neuraminidase (NA) activities but lost its cytotoxic potential.	Formaldehyde	27-35	neuraminidase 1	Homo sapiens	87-89
6241752-0	1984	Agglutination of formalin-fixed, platelet-type von Willebrand"s disease platelets by human von Willebrand factor.	Formaldehyde	17-25	von Willebrand factor	Homo sapiens	91-112
6241752-1	1984	The interaction of platelets and von Willebrand factor (vWF) in platelet-type von Willebrand"s disease (vWD) was characterized using formalin-fixed platelets from the patients.	Formaldehyde	133-141	von Willebrand factor	Homo sapiens	56-59
6241752-2	1984	Formalin-fixed patient platelets were agglutinated directly by human vWF in normal plasma and type IIB vWD plasma, but not in type IIA vWD plasma.	Formaldehyde	0-8	von Willebrand factor	Homo sapiens	69-72
6525533-8	1984	The antithrombin III plus heparin group showed slightly better results than the antithrombin III group in Ucr/Pcr ratio, Clcr and CH2O.	Formaldehyde	130-134	serpin family C member 1	Homo sapiens	4-20
6441159-10	1984	J chain in IgA immunocytes was most intensely stained in sections of ethanol-fixed tissue denatured in acid urea (median score, 3) but was also well revealed after fixation with formalin, acetic acid-formol saline, Bouin"s fluid or Susa fixative (median scores, 1.8-2.0).	Formaldehyde	178-186	joining chain of multimeric IgA and IgM	Homo sapiens	0-7
6486817-7	1984	Formaldehyde was a substrate for the low-Km mitochondrial aldehyde dehydrogenase, as well as for a cytosolic, glutathione-dependent formaldehyde dehydrogenase.	Formaldehyde	0-12	aldehyde dehydrogenase 2 family member	Rattus norvegicus	44-80
6506758-3	1984	Formaldehyde release from methamphetamine was significantly inhibited not only by methimazole but also by inhibitors of the cytochrome P-450 system in liver microsomes from rats, but not guinea-pigs.	Formaldehyde	0-12	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	124-140
28305109-2	1984	Fixation of tissue in a mixture of formaldehyde and cetylpyridinium chloride allows detection of fibronectin only in those zones of the embryo that are not colonized by mesoblast cells.	Formaldehyde	35-47	fibronectin 1	Gallus gallus	97-108
6486817-10	1984	This suggested that part of the formaldehyde oxidation occurred via the mitochondrial aldehyde dehydrogenase, and part via formaldehyde dehydrogenase.	Formaldehyde	32-44	aldehyde dehydrogenase 2 family member	Rattus norvegicus	72-108
6742849-1	1984	Formaldehyde can be metabolized primarily by two different pathways, one involving oxidation by the low-Km mitochondrial aldehyde dehydrogenase, the other involving a specific, glutathione-dependent, formaldehyde dehydrogenase.	Formaldehyde	0-12	aldehyde dehydrogenase 2 family member	Rattus norvegicus	107-143
6084247-1	1984	The immunoperoxidase technique was used to study the localization of pregnancy-associated plasma protein A (PAPP-A) in formaldehyde-fixed paraffin-embedded tissue from normal human placentae at the gestational age of 8, 15 and 40 weeks.	Formaldehyde	119-131	pappalysin 1	Homo sapiens	69-106
6084247-1	1984	The immunoperoxidase technique was used to study the localization of pregnancy-associated plasma protein A (PAPP-A) in formaldehyde-fixed paraffin-embedded tissue from normal human placentae at the gestational age of 8, 15 and 40 weeks.	Formaldehyde	119-131	pappalysin 1	Homo sapiens	108-114
6084247-2	1984	Sections of formaldehyde-fixed tissue treated with a proteolytic enzyme and incubated in antiserum against PAPP-A either raised in goats or rabbits showed that PAPP-A was distributed in the cytoplasm of the syncytiotrophoblast.	Formaldehyde	12-24	pappalysin-1	Oryctolagus cuniculus	160-166
6376628-0	1984	Two new monoclonal antibodies (LN-1, LN-2) reactive in B5 formalin-fixed, paraffin-embedded tissues with follicular center and mantle zone human B lymphocytes and derived tumors.	Formaldehyde	58-66	phytanoyl-CoA 2-hydroxylase	Homo sapiens	31-35
6376628-1	1984	Two monoclonal antibodies (LN-1, LN-2) reactive with B lymphocytes in B5 formalin-fixed, paraffin-embedded tissue sections have been produced by utilizing cell extracts from pokeweed mitogen-stimulated peripheral blood lymphocytes and diffuse histiocytic lymphoma SU-DHL-4 cells, respectively.	Formaldehyde	73-81	phytanoyl-CoA 2-hydroxylase	Homo sapiens	27-31
6464995-2	1984	Approximately 2000 sheets of sandpaper in a 115 m3 (4050 ft3) ship"s storeroom with no mechanical ventilation produced a formaldehyde concentration of at least 4.5 ppm that was uniform throughout the compartment.	Formaldehyde	121-133	inositol polyphosphate-5-phosphatase D	Homo sapiens	62-66
6506920-0	1984	Use of formaldehyde-PBS for serum dilution in the microscopic agglutination test (MAT) for leptospirosis.	Formaldehyde	7-19	cholinergic receptor muscarinic 3	Homo sapiens	20-23
6506920-2	1984	For the preparation of serum dilutions with formaldehyde-PBS, formaldehyde was added to PBS at a final concentration of 0.4%.	Formaldehyde	44-56	cholinergic receptor muscarinic 3	Homo sapiens	57-60
6506920-2	1984	For the preparation of serum dilutions with formaldehyde-PBS, formaldehyde was added to PBS at a final concentration of 0.4%.	Formaldehyde	62-74	cholinergic receptor muscarinic 3	Homo sapiens	57-60
6506920-2	1984	For the preparation of serum dilutions with formaldehyde-PBS, formaldehyde was added to PBS at a final concentration of 0.4%.	Formaldehyde	62-74	cholinergic receptor muscarinic 3	Homo sapiens	88-91
6097153-1	1984	An oil emulsion vaccine against TGE was prepared using a virus suspension produced in tissue culture and inactivated by formaline.	Formaldehyde	120-129	transglutaminase 3	Homo sapiens	32-35
6430122-10	1984	Nearly complete methylation of the lysines of lysozyme, chicken ovomucoid, and ribonuclease was achieved with formaldehyde at pH 7.0 after 2 h at room temperature, with the retention of full activity of the protein without any destruction of tryptophan.	Formaldehyde	110-122	serine peptidase inhibitor, Kazal type 7 (putative)	Gallus gallus	64-73
6230398-1	1984	Rat plasma fibronectin enhances the binding and ingestion of gelatin-coated, formalin-fixed, or tanned sheep erythrocytes by elicited rat peritoneal macrophages.	Formaldehyde	77-85	fibronectin 1	Rattus norvegicus	11-22
6608353-3	1984	The mean 3HTdr incorporation response to the formalin killed form of this strain was 27,409 +/- 5,488 counts per minute for 14 HLA-B27 positive Reiter"s patients compared with 5,414 +/- 3,490 cpm for a control group of 11 HLA-B27 positive normal individuals (P less than 0.0005).	Formaldehyde	45-53	major histocompatibility complex, class I, B	Homo sapiens	127-134
6608353-3	1984	The mean 3HTdr incorporation response to the formalin killed form of this strain was 27,409 +/- 5,488 counts per minute for 14 HLA-B27 positive Reiter"s patients compared with 5,414 +/- 3,490 cpm for a control group of 11 HLA-B27 positive normal individuals (P less than 0.0005).	Formaldehyde	45-53	major histocompatibility complex, class I, B	Homo sapiens	222-229
6696954-0	1984	Endocytosis of formaldehyde-denatured serum albumin by nonparenchymal liver cells in vitro.	Formaldehyde	15-27	albumin	Rattus norvegicus	44-51
6696954-1	1984	The uptake and degradation of 125I-labeled formaldehyde-denatured serum albumin in nonparenchymal rat liver cells were studied in vitro.	Formaldehyde	43-55	albumin	Rattus norvegicus	72-79
6696954-2	1984	Nonparenchymal cells bound formaldehyde-denatured serum albumin at two types of binding site, one with a high affinity and one a low affinity.	Formaldehyde	27-39	albumin	Rattus norvegicus	56-63
6696954-9	1984	Unlabeled acetylated, as well as malondialdehyde treated, serum albumin reduced the uptake of 125I-labeled formaldehyde-denatured serum albumin as effectively as unlabeled formaldehyde-denatured serum albumin itself.	Formaldehyde	107-119	albumin	Rattus norvegicus	64-71
6696954-9	1984	Unlabeled acetylated, as well as malondialdehyde treated, serum albumin reduced the uptake of 125I-labeled formaldehyde-denatured serum albumin as effectively as unlabeled formaldehyde-denatured serum albumin itself.	Formaldehyde	107-119	albumin	Rattus norvegicus	136-143
6696954-9	1984	Unlabeled acetylated, as well as malondialdehyde treated, serum albumin reduced the uptake of 125I-labeled formaldehyde-denatured serum albumin as effectively as unlabeled formaldehyde-denatured serum albumin itself.	Formaldehyde	107-119	albumin	Rattus norvegicus	136-143
6388216-1	1984	Eight hemangioblastomas and two hemangiopericytomas were studied using indirect immunoperoxidase stains for fibronectin (FN) and glial fibrillary acidic protein (GFAP) in formalin-fixed, paraffin-embedded surgical specimens.	Formaldehyde	171-179	glial fibrillary acidic protein	Homo sapiens	162-166
6747048-6	1984	Supplementing tyrosine to the formaldehyde-treated diet increased milk production by 1.6 kg/day, but adding tyrosine to the untreated diet did not affect milk yield.	Formaldehyde	30-42	Weaning weight-maternal milk	Bos taurus	66-70
6373941-0	1984	Re: Apparent staining of mast cells for fibronectin with a peroxidase-antiperoxidase method on formalin fixed sections.	Formaldehyde	95-103	fibronectin 1	Homo sapiens	40-51
6141004-1	1984	The expression of the carbohydrate structure defined by monoclonal antibody to murine stage-specific embryonic antigen 1 (SSEA-1) was examined, using immunofluorescence, in formalin-fixed, paraffin-embedded sections of normal fetal and adult human colon and human colonic adenocarcinoma.	Formaldehyde	173-181	fucosyltransferase 4	Mus musculus	122-128
6703343-3	1984	We have been able to reduce the atmospheric concentration of formaldehyde in our dissection rooms to below the detection limit of a conventional Drager tube multigas analyzer (i.e., below 0.5 ppm or 0.6 mg formaldehyde/m3 air), by extracting previously formaldehyde-fixed material for more than 3 months in 1% phenoxyethanol in tap water.	Formaldehyde	61-73	nuclear RNA export factor 1	Homo sapiens	328-331
6366091-5	1984	Immunoperoxidase staining of CEA (PAP method) was carried out using formalin-fixed paraffin embedded sections of 37 tumors.	Formaldehyde	68-76	CEA cell adhesion molecule 3	Homo sapiens	29-32
6361117-8	1984	It was concluded that, for the localization of NGF at the light microscopic level, a brief (1 hr) buffered formaldehyde fixation is optimal.	Formaldehyde	107-119	nerve growth factor	Mus musculus	47-50
6210275-8	1984	An additional masking effect due to extraneous protein was revealed by DIF when ethanol-fixed sections had been soaked in bovine serum albumin and postfixed with formaldehyde; unmasking was achieved by proteolytic treatment of the sections.	Formaldehyde	162-174	tumor necrosis factor	Homo sapiens	71-74
6363816-2	1984	Utilizing an immunofluorescence procedure for the cellular and extracellular localization of eosinophil MBP in formalin-fixed, paraffin-embedded tissues, we studied skin biopsies from onchocerciasis patients before and during treatment with topically or orally administered DEC. Before DEC, there was little or no inflammatory response in either dermis or epidermis and microfilariae were essentially intact.	Formaldehyde	111-119	myelin basic protein	Homo sapiens	104-107
6207518-5	1984	Procedures used for the histochemical demonstration of formalin-resistant human prostatic acid phosphatase are not, therefore, directly applicable to rat ventral prostate.	Formaldehyde	55-63	acid phosphatase 3	Homo sapiens	80-106
6316986-5	1983	The oxidation of t-butyl alcohol appeared to be mediated by hydroxyl radicals, or by a species with the oxidizing power of the hydroxyl radical, because the production of formaldehyde plus acetone was (a) inhibited by competing scavengers of the hydroxyl radical; (b) stimulated by the addition of iron-EDTA; and (c) inhibited by catalase.	Formaldehyde	171-183	catalase	Homo sapiens	330-338
6195915-0	1983	Comparison of formalin- and acetone-fixation for immunohistochemical detection of carcinoembryonic antigen (CEA) and keratin.	Formaldehyde	14-22	CEA cell adhesion molecule 3	Homo sapiens	82-106
6195915-3	1983	Cold acetone was found to be superior to formalin for the preservation of CEA and keratin antigenic activities in a variety of benign and malignant tissues.	Formaldehyde	41-49	CEA cell adhesion molecule 3	Homo sapiens	74-77
6317699-1	1983	Thrombin binding to formaldehyde-fixed mouse embryo (ME) cells was visualized by indirect immunofluorescence as a dot-like pattern with dots of approximately 500 nm diameter located over the entire cell surface.	Formaldehyde	20-32	coagulation factor II	Mus musculus	0-8
6317019-1	1983	Pulmonary angiotensin converting enzyme has been reductively methylated by using formaldehyde and sodium cyanoborohydride.	Formaldehyde	81-93	angiotensin I converting enzyme	Homo sapiens	10-39
6609270-5	1983	Re-used dialyzers also differed significantly from either new or formalin-fixed new dialyzers in that C3b antigen could be readily detected within them even after extensive washing.	Formaldehyde	65-73	endogenous retrovirus group K member 3	Homo sapiens	102-105
6373974-3	1983	Lysozyme was detected with formalin-fixed, paraffin-embedded materials in 82 cases of synovial tissue (RA 50 cases, non-RA 32 cases) using the unlabelled peroxidase anti-peroxidase (PAP) method following Taylor, et al.	Formaldehyde	27-35	lysozyme	Homo sapiens	0-8
6193873-1	1983	The immunoperoxidase technique was used to study the localization and distribution of antigens reactive with two monoclonal antibodies, D83.21 and P6.2, produced against cultured prostate tumor cells, in formalin-fixed, paraffin-embedded histological sections of human tissues.	Formaldehyde	204-212	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	147-151
6196132-5	1983	Suramin (500 micrograms/ml) decreased both the rate of uptake of formaldehyde-denatured 125I-labelled bovine serum albumin (BSA) (an adsorptive substrate) and the rate of its subsequent intracellular degradation.	Formaldehyde	65-77	albumin	Rattus norvegicus	109-122
6310227-1	1983	Two hundred and two benign and malignant soft tissue lesions were studied for the presence of S-100 protein by means of the peroxidase-antiperoxidase technique on formalin-fixed, paraffin-embedded tissue.	Formaldehyde	163-171	S100 calcium binding protein A1	Homo sapiens	94-99
6605342-7	1983	VWF binding to formaldehyde-fixed platelets was dependent on the presence of a promoter such as ristocetin.	Formaldehyde	15-27	von Willebrand factor	Bos taurus	0-3
6387676-5	1983	Ten percent buffered Formalin was superior to Bouin"s fixative and alcoholic Formalin for the demonstration of HPL.	Formaldehyde	21-29	galectin 1	Homo sapiens	111-114
6387676-5	1983	Ten percent buffered Formalin was superior to Bouin"s fixative and alcoholic Formalin for the demonstration of HPL.	Formaldehyde	77-85	galectin 1	Homo sapiens	111-114
6871871-1	1983	Groups of approximately 120 male and 120 female Fischer 344 rats and C57BL/6 X C3H F1 mice were exposed by inhalation to 0, 2.0, 5.6, and 14.3 ppm of formaldehyde gas 6 hr/day, 5 days/week, for 24 months.	Formaldehyde	150-162	growth arrest specific 6	Mus musculus	163-168
6652560-2	1983	Model reactions of glycine ethyl ester and piperidine with formaldehyde and melatonin suggested that coupling first occurred through the indole nitrogen and then a stable bond was formed at C-2.	Formaldehyde	59-71	complement C2	Homo sapiens	190-193
6652560-3	1983	Cross-reaction studies of antisera stimulated by melatonin, formaldehyde, and protein conjugates support the hypothesis that C-2 is the site of conjugation of melatonin to protein.	Formaldehyde	60-72	complement C2	Homo sapiens	125-128
6413850-2	1983	The Adh gene from 4 formaldehyde-generated ADH-negative mutants of Drosophila melanogaster has been cloned and sequenced.	Formaldehyde	20-32	Alcohol dehydrogenase	Drosophila melanogaster	4-7
6874280-1	1983	The authors sought S-100 protein in sections cut from formalin- or glutaraldehyde-fixed, paraffin-embedded tumors from the eye and other sites by an immunoperoxidase technique, using rabbit antibovine S-100 protein antiserum, swine antirabbit serum, a peroxidase-antiperoxidase preparation, and amino-ethylcarbizole as developer.	Formaldehyde	54-62	S100 calcium binding protein A1	Homo sapiens	19-24
6413850-2	1983	The Adh gene from 4 formaldehyde-generated ADH-negative mutants of Drosophila melanogaster has been cloned and sequenced.	Formaldehyde	20-32	Alcohol dehydrogenase	Drosophila melanogaster	43-46
6682428-7	1983	Milk protein (total nitrogen x 6.38) produced by cows fed soybean meal treated with formaldehyde was less than by cows fed untreated soybean meal during days 22 to 63 and during days 22 to 119 (47 versus 44 kg/cow and 103 versus 97 kg/cow).	Formaldehyde	84-96	Weaning weight-maternal milk	Bos taurus	0-4
6350149-1	1983	Using the sensitive peroxidase, anti-peroxidase immunohistological technique, carcinoembryonic antigen (CEA) was studied in formalin-fixed, paraffin-embedded cervical specimens from 225 patients.	Formaldehyde	124-132	CEA cell adhesion molecule 3	Homo sapiens	78-102
6350149-1	1983	Using the sensitive peroxidase, anti-peroxidase immunohistological technique, carcinoembryonic antigen (CEA) was studied in formalin-fixed, paraffin-embedded cervical specimens from 225 patients.	Formaldehyde	124-132	CEA cell adhesion molecule 3	Homo sapiens	104-107
6193599-9	1983	SP immunoreaction was demonstrated in formaldehyde-fixed cryostat sections by either the indirect immunofluorescence technique or the peroxidase-antiperoxidase procedure.	Formaldehyde	38-50	tachykinin precursor 1	Homo sapiens	0-2
6342431-6	1983	The exposure to formaldehyde gas from its release from urea-formaldehyde foam has elicited subjective complaints of sensory irritation and unresolved controversy and regulatory action regarding its toxicity to humans.	Formaldehyde	16-28	gastrin	Homo sapiens	29-32
6342431-6	1983	The exposure to formaldehyde gas from its release from urea-formaldehyde foam has elicited subjective complaints of sensory irritation and unresolved controversy and regulatory action regarding its toxicity to humans.	Formaldehyde	60-72	gastrin	Homo sapiens	29-32
6347490-1	1983	Alpha-1-antitrypsin detected by immunoperoxidase has been used as a marker for infiltrating monocytes on formalin-fixed, paraffin-embedded sections of 75 renal biopsies.	Formaldehyde	105-113	serpin family A member 1	Homo sapiens	0-19
6353850-1	1983	Immunoperoxidase staining for myoglobin was performed on formalin-fixed, paraffin-embedded tissues of normal human skeletal muscle and rhabdomyosarcomas in order to assess its potential diagnostic value.	Formaldehyde	57-65	myoglobin	Homo sapiens	30-39
6403464-1	1983	All of 23 different preparations of formaldehyde-fixed and heat-killed bacteria induced the appearance of high levels of interferon (IFN) in cultures of human peripheral blood mononuclear leukocytes.	Formaldehyde	36-48	interferon alpha 1	Homo sapiens	121-137
6300382-1	1983	Bound sialic acids on rat spermatozoa were assayed by oxidation with 1 mM-NaIO4 at 0 degree C, liberating C-9 as formaldehyde which was further quantitated using 3-methyl-2-benzothiazolinone.	Formaldehyde	113-125	complement C9	Rattus norvegicus	106-109
6411646-2	1983	Reductive methylation of the three amino groups of porcine insulin was accomplished by incubation with formaldehyde and sodium cyanoborohydride.	Formaldehyde	103-115	insulin	Homo sapiens	59-66
6412493-3	1983	In the other case formalin-treated sheep red blood cells sensitized with group-specific polysaccharides obtained by alcohol precipitation from the cultural fluid of group A, C and Y meningococci with subsequent heating (designated as A-2, C-2, Y) were used.	Formaldehyde	18-26	ATPase H+ transporting V0 subunit a2	Homo sapiens	234-237
6412493-3	1983	In the other case formalin-treated sheep red blood cells sensitized with group-specific polysaccharides obtained by alcohol precipitation from the cultural fluid of group A, C and Y meningococci with subsequent heating (designated as A-2, C-2, Y) were used.	Formaldehyde	18-26	complement C2	Ovis aries	239-242
6414108-2	1983	Both forms of cytochrome P-450 were active in the demethylation of DMN, cytochrome P-450 from PB-treated animals being more efficient, generating nearly twice as much formaldehyde per nmol of haemoprotein.	Formaldehyde	167-179	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	14-30
6414108-2	1983	Both forms of cytochrome P-450 were active in the demethylation of DMN, cytochrome P-450 from PB-treated animals being more efficient, generating nearly twice as much formaldehyde per nmol of haemoprotein.	Formaldehyde	167-179	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	72-88
6404224-2	1983	Heterozygous and homozygous glycophorin A were partially and fully reductively methylated with 13C-enriched formaldehyde in the presence of sodium cyanoborohydride.	Formaldehyde	108-120	glycophorin A (MNS blood group)	Homo sapiens	28-41
6296101-4	1983	The production of ethylene from 4-ketothiomethylbutyrate or of formaldehyde from either dimethyl sulfoxide or tertiary butyl alcohol was measured in the presence of NADPH plus reductase or NADPH plus reductase plus cytochrome P-450.	Formaldehyde	63-75	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	215-231
6192074-2	1983	On the basis of his response to folate treatment, a partially-reversible defect in the formation of activated formaldehyde in the reaction catalyzed by sarcosine dehydrogenase was considered to be the most likely site.	Formaldehyde	110-122	sarcosine dehydrogenase	Homo sapiens	152-175
6188239-0	1983	Formaldehyde production promoted by rat nasal cytochrome P-450-dependent monooxygenases with nasal decongestants, essences, solvents, air pollutants, nicotine, and cocaine as substrates.	Formaldehyde	0-12	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	46-62
6188239-1	1983	To identify compounds which might be metabolized to formaldehyde in the nasal cavity, 32 potential substrates for cytochrome P-450-dependent monooxygenases were screened with rat nasal and, for comparison, liver microsomes.	Formaldehyde	52-64	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	114-130
6183384-1	1982	Purified bovine factor VIII: R was radiolabeled and its binding to formalin-fixed human platelets measured.	Formaldehyde	67-75	coagulation factor VIII	Bos taurus	16-27
6184303-6	1982	In adult Niemann-Pick disease, both the characteristic staining reactions and the elevation of tissue sphingomyelin may be demonstrated in formalin-fixed material.	Formaldehyde	139-147	protein interacting with PRKCA 1	Homo sapiens	17-21
6301296-1	1982	The presence of S-100 protein was immunohistochemically studied in many types of formalin-fixed and paraffin-embedded tumors (260 cases).	Formaldehyde	81-89	S100 calcium binding protein A1	Homo sapiens	16-21
7187364-1	1982	Five formaldehyde-induced deficiencies that uncover unc-22 IV, a gene affecting muscle structure in the nematode Caenorhabditis elegans were isolated and positioned.	Formaldehyde	5-17	Twitchin	Caenorhabditis elegans	52-58
6297236-1	1982	Distribution of intracytoplasmic lysozyme in proliferative and neoplastic fibrohistiocytic lesions and non fibrohistiocytic tumors was studied by immunoperoxidase technique on formalin fixed, paraffin-embedded sections.	Formaldehyde	176-184	lysozyme	Homo sapiens	33-41
7050870-3	1982	The specific activities for methylenetetrahydrofolate reductase were 6.62 +/- 0.51, 4.42 +/- 0.31, and 2.60 +/- 0.40 (nmoles formaldehyde/mg protein/h, mean +/- S.E.)	Formaldehyde	125-137	methylenetetrahydrofolate reductase	Homo sapiens	28-63
6752046-1	1982	We sought S-100 protein in sections prepared from formalin-fixed paraffin-embedded tumor and normal tissues by an immunoperoxidase technique with a rabbit anti-bovine S-100 protein antiserum as first antibody and aminoethyl carbazole as developer.	Formaldehyde	50-58	S100 calcium binding protein A1	Homo sapiens	10-15
6926754-1	1982	The differential effects of lower incubation temperature on the digestion of formaldehyde-denatured 125I-labelled bovine serum albumin by intact rat peritoneal macrophages and by macrophage homogenates were studied.	Formaldehyde	77-89	albumin	Rattus norvegicus	121-134
6926756-0	1982	[Induction by formaldehyde of conformational changes from helix to globule in the myoglobin molecule].	Formaldehyde	14-26	myoglobin	Homo sapiens	82-91
6926756-1	1982	The secondary structure of myoglobin, treated with formaldehyde, has been studied by absorption spectroscopy, circular dichroism and gel-chromatography.	Formaldehyde	51-63	myoglobin	Homo sapiens	27-36
6926756-5	1982	The denaturation of myoglobin in the presence of formaldehyde is not cooperative in contrast to classical denaturation by pH, temperature, urea and other agents.	Formaldehyde	49-61	myoglobin	Homo sapiens	20-29
6926756-7	1982	Possible mechanisms of denaturation of myoglobin in the presence of formaldehyde are discussed.	Formaldehyde	68-80	myoglobin	Homo sapiens	39-48
6284736-3	1982	The fragment C-2 has now been selectively methylated with formaldehyde and sodium cyanoborohydride to give the epsilon-dimethylamino derivatives of Lys-30, 40, and 41 in 96-99% average yield.	Formaldehyde	58-70	complement C2	Homo sapiens	13-16
7044402-4	1982	TdT cells can be identified in formalin (but not in Bouin"s or Carnoy"s) fixed paraffin-embedded tissues, and the preservation of morphological details is excellent.	Formaldehyde	31-39	DNA nucleotidylexotransferase	Homo sapiens	0-3
6179983-9	1982	Formaldehyde fixation, combined with pronase treatment of tissue sections and prolonged exposure (20 hr) to antibody, enhanced markedly the staining intensity for lysozyme; ethanol fixation and 30-min incubation with conjugates generally afforded better localization of the other epithelial components.	Formaldehyde	0-12	lysozyme	Homo sapiens	163-171
7083936-6	1982	Specific IgE antibodies directed against formaldehyde-human serum albumin conjugate could not be demonstrated using the radioallergosorbent test.	Formaldehyde	41-53	albumin	Homo sapiens	60-73
6178285-3	1982	B2m was assessed by three methods: PAP technic on formalin-fixed, paraffin-embedded tissue; indirect immunofluorescence on frozen sections; and radioimmunoassay on soluble tumor extracts.	Formaldehyde	50-58	major histocompatibility complex, class I, G	Homo sapiens	0-3
6801055-2	1982	The antibody has high neutralizing ability to the enzyme activity and, in the presence of formalin fixed Staphylococcus aureus, precipitates a Mr = 40,000 polypeptide from the crude extract and the partially purified DNA polymerase beta which were prepared from [35S]methionine-labeled chick embryonic cells.	Formaldehyde	90-98	DNA polymerase beta	Gallus gallus	217-236
7090425-3	1982	The enzyme system involved was dependent on cytochrome P-450 and the main metabolites were desmethylimipramine (DMI), formaldehyde and p-chlorobenzoic acid.	Formaldehyde	118-130	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	44-60
6801111-1	1982	The immunohistochemical detection of factor VIII/von Willebrand factor antigen (FVIII/vWF-AG) in formalin-fixed paraffin-embedded tissues was investigated using the peroxidase-antiperoxidase (PAP) method.	Formaldehyde	97-105	coagulation factor VIII	Homo sapiens	80-85
6801111-1	1982	The immunohistochemical detection of factor VIII/von Willebrand factor antigen (FVIII/vWF-AG) in formalin-fixed paraffin-embedded tissues was investigated using the peroxidase-antiperoxidase (PAP) method.	Formaldehyde	97-105	von Willebrand factor	Homo sapiens	86-89
7041611-0	1982	Demonstration of myoglobin in formalin-fixed renal sections by immunoperoxidase technic.	Formaldehyde	30-38	myoglobin	Homo sapiens	17-26
7041611-1	1982	The use of an immunohistochemical technic offers a very sensitive method to detect myoglobin in formalin-fixed, paraffin-embedded tissues.	Formaldehyde	96-104	myoglobin	Homo sapiens	83-92
6820938-3	1982	Rather than the less specific phosphotungstic acid hematoxylin (PTAH) or Holzer"s stain, antibody to GFAP protein is a relatively rapid, simple, and reliable immunohistochemical technique for formalin-fixed and paraffin-embedded tissue.	Formaldehyde	192-200	glial fibrillary acidic protein	Homo sapiens	101-105
6821322-6	1982	Since NF1 shows a broad cross-species reactivity and is able to react on formaldehyde-fixed tissue, it should be a useful reagent to study differential neurofilament expression and organization in embryonic, adult and pathological tissues.	Formaldehyde	73-85	neurofibromin 1	Mus musculus	6-9
6288968-0	1982	Acceleration of HCN oligomerization by formaldehyde and related compounds: implications for prebiotic syntheses.	Formaldehyde	39-51	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	16-19
6294975-1	1982	Alpha 1-antitrypsin has been examined in formalin-fixed, paraffin-embedded liver specimens from Greek patients with cirrhosis (35 cases) and hepatoma (55 cases) by peroxidase-antiperoxidase (PAP) method.	Formaldehyde	41-49	serpin family A member 1	Homo sapiens	0-19
7057422-8	1982	Also, both folic acid and 5-(CHO)-THF were reductively alkylated with formaldehyde to give 10-methylfolic acid (6) and 5-(CHO)-10-(CH3)-THF (28), respectively.	Formaldehyde	70-82	thin fur	Mus musculus	34-37
7057422-8	1982	Also, both folic acid and 5-(CHO)-THF were reductively alkylated with formaldehyde to give 10-methylfolic acid (6) and 5-(CHO)-10-(CH3)-THF (28), respectively.	Formaldehyde	70-82	thin fur	Mus musculus	136-139
6280394-1	1982	The effect of formaldehyde on the conformation of Sendai virus ribonucleoprotein (RNP) was studied by electron microscopy and a spectrophotometric method.	Formaldehyde	14-26	RNA binding region (RNP1, RRM) containing 3	Homo sapiens	82-85
6280394-2	1982	The effect of formaldehyde on RNP conformation was found to depend strongly on the ionic strength of the solution.	Formaldehyde	14-26	RNA binding region (RNP1, RRM) containing 3	Homo sapiens	30-33
7057422-7	1982	Reductive dialkylation of THF with formaldehyde gave 5,10-(CH3)2-THF (27), whereas glyoxal gave 5,10-CH2CH2)-THF (10).	Formaldehyde	35-47	thin fur	Mus musculus	26-29
7057422-7	1982	Reductive dialkylation of THF with formaldehyde gave 5,10-(CH3)2-THF (27), whereas glyoxal gave 5,10-CH2CH2)-THF (10).	Formaldehyde	35-47	thin fur	Mus musculus	65-68
7057422-7	1982	Reductive dialkylation of THF with formaldehyde gave 5,10-(CH3)2-THF (27), whereas glyoxal gave 5,10-CH2CH2)-THF (10).	Formaldehyde	35-47	thin fur	Mus musculus	65-68
6280394-3	1982	Under conditions of a low ionic strength in the presence of 1.5% formaldehyde the tightly coiled rods of RNP stained with uranyl acetate become loosely coiled or almost completely extended.	Formaldehyde	65-77	RNA binding region (RNP1, RRM) containing 3	Homo sapiens	105-108
6803540-1	1981	Bovine factor VIII/platelet aggregating factor was adsorbed into gold granules and the protein-gold complex added to either formalin-fixed or fresh washed human platelets.	Formaldehyde	124-132	coagulation factor VIII	Bos taurus	7-18
6280394-4	1982	At the same time, formaldehyde reaction with RNP results in a decrease in extinction of the RNP suspension in the 250 to 290 spectral region.	Formaldehyde	18-30	RNA binding region (RNP1, RRM) containing 3	Homo sapiens	45-48
6280394-4	1982	At the same time, formaldehyde reaction with RNP results in a decrease in extinction of the RNP suspension in the 250 to 290 spectral region.	Formaldehyde	18-30	RNA binding region (RNP1, RRM) containing 3	Homo sapiens	92-95
6280394-5	1982	However, RNP incubation with formaldehyde in the presence of 0.5M NaCl caused no changes in the morphology and spectral properties of the RNP under study.	Formaldehyde	29-41	RNA binding region (RNP1, RRM) containing 3	Homo sapiens	9-12
6170480-2	1981	The measurement is accomplished by transforming creatine to formaldehyde in reactions catalyzed by creatinase (creatine amidinohydrolase) and sarcosine dehydrogenase.	Formaldehyde	60-72	sarcosine dehydrogenase	Homo sapiens	99-165
6118261-5	1981	IR-somatostatin in hypothalamus and pancreas decreased gradually to a minimum at 7 h. Another duodenal ulcerogen, propionitrile (10 mg/100 g bw, s.c.) which is more toxic than cysteamine, and several stressful procedures including ether anesthesia, restraint and s.c. formalin did not lower stomach or duodenal IR-somatostatin.	Formaldehyde	268-276	somatostatin	Rattus norvegicus	3-15
7020318-5	1981	Formalin-fixed pancreatic sections were stained for TRF, glucagon and insulin by peroxidase, antiperoxidase (PAP) complex method.	Formaldehyde	0-8	thyrotropin releasing hormone	Rattus norvegicus	52-55
6167611-0	1981	Importance of fixation in immunohistochemistry: use of formaldehyde solutions at variable pH for the localization of tyrosine hydroxylase.	Formaldehyde	55-67	tyrosine hydroxylase	Homo sapiens	117-137
6167611-4	1981	In the present study, this principle is demonstrated using the localization of tyrosine hydroxylase in the dopaminergic system with formaldehyde as the fixative.	Formaldehyde	132-144	tyrosine hydroxylase	Homo sapiens	79-99
6167611-10	1981	The results obtained by increasing the pH of the second solution demonstrated that complete fixation of tyrosine hydroxylase in the dopaminergic system with formaldehyde maybe obtained using a very basic formaldehyde solution (pH 11) while still retaining immunoreactivity of the enzyme.	Formaldehyde	157-169	tyrosine hydroxylase	Homo sapiens	104-124
6167611-10	1981	The results obtained by increasing the pH of the second solution demonstrated that complete fixation of tyrosine hydroxylase in the dopaminergic system with formaldehyde maybe obtained using a very basic formaldehyde solution (pH 11) while still retaining immunoreactivity of the enzyme.	Formaldehyde	204-216	tyrosine hydroxylase	Homo sapiens	104-124
7019429-3	1981	Preincubation of washed ram spermatozoa with 0.025% formaldehyde increased GPI levels but decreased LDH concentration in the extracellular fluid while hexokinase release was unaffected.	Formaldehyde	52-64	glucose-6-phosphate isomerase	Homo sapiens	75-78
6167343-1	1981	Paraffin-embedded tissues from 15 women with breast or endometrial carcinomas were analyzed in a study designed to explore the possible value and validity of an immunoperoxidase method for the detection of estrogen receptor in formalin-fixed paraffin-embedded tissue.	Formaldehyde	227-235	estrogen receptor 1	Homo sapiens	206-223
6786321-6	1981	Their interaction with surface receptors for bovine factor VIII on either viable or formalin-fixed human platelets was demonstrated by transmission and scanning electron microscopy.	Formaldehyde	84-92	coagulation factor VIII	Bos taurus	52-63
6270668-4	1981	A quantitative binding assay employing anti-beta-galactosidase and IgGsorb (formalin-fixed Staphylococcus aureus) was devised to study the binding of 125I-labeled receptor to beta-galactosidase.	Formaldehyde	76-84	galactosidase beta 1	Bos taurus	175-193
7193682-2	1981	Native and formaldehyde-fixed filaments of purified platelet myosin filaments each consisting of approximately 30 myosin molecules bound an equivalent number of ferritin-antimyosin conjugates.	Formaldehyde	11-23	myosin heavy chain 14	Homo sapiens	61-67
7015823-1	1981	Hemoglobin and myoglobin have been identified in formalin-fixed paraffin-embedded sections of human autopsy material with the indirect fluorescent antibody technic.	Formaldehyde	49-57	myoglobin	Homo sapiens	15-24
7225408-2	1981	Solutions of different ratios of alpha 1 and alpha 2 chains, one of which was labelled with [14C]- or [3H]glycine, were renatured to form triple-helical, rod-shaped molecules, then cross-linked intramolecularly with formaldehyde.	Formaldehyde	216-228	adrenoceptor alpha 1D	Homo sapiens	33-52
7193682-2	1981	Native and formaldehyde-fixed filaments of purified platelet myosin filaments each consisting of approximately 30 myosin molecules bound an equivalent number of ferritin-antimyosin conjugates.	Formaldehyde	11-23	myosin heavy chain 14	Homo sapiens	114-120
6260366-9	1981	It is concluded that under the physiological conditions, formalin fixation of the tissue causes the pro-opiocortin molecule to be "trapped" in a conformation such that either ACTH or beta-endorphin-like determinants are available for reacting with the appropriate antiserum.	Formaldehyde	57-65	proopiomelanocortin	Homo sapiens	183-197
7207485-5	1981	2 concentrations of formaldehyde, 0.1% and 0.07%, were found to be mutagenic, inducing both point mutations and deficiencies in the unc-22 region of linkage group IV.	Formaldehyde	20-32	Twitchin	Caenorhabditis elegans	132-138
6164245-1	1981	The immunoperoxidase technique was used to study the occurrence of placenta-associated plasma protein A (PAPP-A, SP4) in formalin-fixed paraffin-embedded tissue specimens from 15 hydatidiform moles, 6 invasive moles and 7 choriocarcinomas.	Formaldehyde	121-129	pappalysin 1	Homo sapiens	67-103
6164245-1	1981	The immunoperoxidase technique was used to study the occurrence of placenta-associated plasma protein A (PAPP-A, SP4) in formalin-fixed paraffin-embedded tissue specimens from 15 hydatidiform moles, 6 invasive moles and 7 choriocarcinomas.	Formaldehyde	121-129	pappalysin 1	Homo sapiens	105-111
6164245-1	1981	The immunoperoxidase technique was used to study the occurrence of placenta-associated plasma protein A (PAPP-A, SP4) in formalin-fixed paraffin-embedded tissue specimens from 15 hydatidiform moles, 6 invasive moles and 7 choriocarcinomas.	Formaldehyde	121-129	Sp4 transcription factor	Homo sapiens	113-116
6176509-0	1981	Study of some properties of ABO test sera by using the method of phagocytosing erythrocytes treated with formaldehyde in vitro.	Formaldehyde	105-117	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	28-31
7446713-3	1980	Lungs volumes, both distended with air at 30 cm H2O and with formalin at 25 cm H2O, were increased in beta APN-treated animals.	Formaldehyde	61-69	alanyl aminopeptidase, membrane	Rattus norvegicus	107-110
7213635-1	1980	The steady-state kinetic mechanism of human liver formaldehyde dehydrogenase (formaldehyde:NAD+ oxidoreductase (glutathione-formylating), EC 1.2.1.1) was investigated by product inhibition of the forward and the reverse reactions catalyzed by the enzyme.	Formaldehyde	50-62	hydroxysteroid 17-beta dehydrogenase 6	Homo sapiens	96-110
7458963-0	1980	Effect of cadmium acetate on the uptake and degradation of formaldehyde-treated 125I-labelled human serum albumin in rat liver non-parenchymal cells in vitro.	Formaldehyde	59-71	albumin	Rattus norvegicus	106-113
6160101-10	1980	Binding structures for aggregated beta 2-microglobulin on oral streptococci were sensitive to pepsin, heat, and formaldehyde treatment.	Formaldehyde	112-124	beta-2-microglobulin	Homo sapiens	34-54
7430128-4	1980	HCHO modifies the exocyclic amino groups of CMP, GMP, and AMP and prevents hydrogen bonding but reacts only slightly with UMP.	Formaldehyde	0-4	5'-nucleotidase, cytosolic II	Homo sapiens	49-52
7002956-1	1980	The distribution of fibronectin in 42 renal biopsies was investigated using an indirect immunoperoxidase technique on paraffin sections of formalin-fixed material.	Formaldehyde	139-147	fibronectin 1	Homo sapiens	20-31
7008496-3	1980	On comparing frozen sections of unfixed material with paraffin sections of formalin fixed material a slightly better preservation of the immunoreactivity of AAT was observed in frozen sections.	Formaldehyde	75-83	serpin family A member 1	Homo sapiens	157-160
7008496-8	1980	Pretreatment with proteolytic enzymes of deparaffinized sections of formalin fixed tissue caused an increase in demonstrable AAT, especially in tissues fixed for extremely long periods of time.	Formaldehyde	68-76	serpin family A member 1	Homo sapiens	125-128
7008496-10	1980	It is concluded that for the immunohistochemical demonstration of AAT in liver tissue the employment of indirect immunoperoxidase staining on formalin fixed, paraffin embedded material is recommendable as it combines a sensitive staining technique with a satisfactory preservation of immunoreactivity and tissue morphology.	Formaldehyde	142-150	serpin family A member 1	Homo sapiens	66-69
7001480-1	1980	By use of the indirect peroxidase-antiperoxidase complex immunocytochemical technique, antibody to purified human renal renin was applied to formalin-fixed paraffin sections of human cadaver brain.	Formaldehyde	141-149	renin	Homo sapiens	120-125
7002401-9	1980	After formaldehyde fixation or preincubation at 37 degrees C the interaction of the UMC with anti-Fab conjugates could no longer be demonstrated.	Formaldehyde	6-18	FA complementation group B	Homo sapiens	98-101
7001829-7	1980	In further study of these specimens an immunoperoxidase staining technique was used to stain for hCG in formalin-fixed sections of the same tumours assayed by RIA.	Formaldehyde	104-112	chorionic gonadotropin subunit beta 5	Homo sapiens	97-100
6108039-9	1980	The unspecific cholinesterase, localized in the hippocampal region within vessel and capillary walls, exists in an electrophoretic mobile, formalin-sensitive form.	Formaldehyde	139-147	butyrylcholinesterase	Rattus norvegicus	15-29
6988706-3	1980	This repair was observed for wild-type cells as well as for a UV-sensitive, excision-deficient mutant (rad1-3), also sensitive to the lethal effect of formaldehyde.	Formaldehyde	151-163	ssDNA endodeoxyribonuclease RAD1	Saccharomyces cerevisiae S288C	103-109
6991056-2	1980	The peroxidase-antiperoxidase immunohistochemical method was then used to demonstrate the localization of choline acetyltransferase in formalin-fixed and paraffin-embedded human cerebellum from normal as well as from Huntington"s disease brains.	Formaldehyde	135-143	LOW QUALITY PROTEIN: choline O-acetyltransferase	Oryctolagus cuniculus	106-131
7007298-12	1980	Frozen sections of formaldehyde and glutaraldehyde fixed tissue blocks are inferior due to a higher inhibition of DPP II and less precise localization of the azo-dye.	Formaldehyde	19-31	dipeptidylpeptidase 7	Rattus norvegicus	114-120
6772608-0	1980	Immunoperoxidase localisation of fibronectin in glomeruli of formalin fixed paraffin processed renal tissue.	Formaldehyde	61-69	fibronectin 1	Homo sapiens	33-44
6772608-1	1980	An indirect immunoperoxidase technique was used to demonstrate fibronectin in sections of routine formalin fixed paraffin embedded renal tissue.	Formaldehyde	98-106	fibronectin 1	Homo sapiens	63-74
7372500-3	1980	Formation of mercaptides as the result of adding organomercuric salts to neutral formalin used for fixation was found to protect protein thiols from autoxidation, provided the tissues were washed in distilled and not tap water.	Formaldehyde	81-89	SEC14 like lipid binding 2	Homo sapiens	217-220
6996310-3	1980	Lysozyme-immunoreactivity was well preserved after fixation of tumor tissue in liquid formaldehyde followed by postfixation in osmium tetroxide.	Formaldehyde	86-98	lysozyme	Homo sapiens	0-8
316281-0	1979	Rapid assay for von Willebrand factor activity using formalin-fixed platelets and microtitration technic.	Formaldehyde	53-61	von Willebrand factor	Homo sapiens	16-37
540045-2	1979	When added to the serum-free medium in which 17.5-day rat yolk sacs were incubated, formaldehyde-denatured 125I-labelled bovine serum albumin was rapidly degraded.	Formaldehyde	84-96	albumin	Rattus norvegicus	128-141
540045-8	1979	These findings indicate that, in vitro, formaldehyde-denatured 125I-labelled bovine serum albumin is digested by rat yolk sacs exclusively intracellularly, within lysosomes.	Formaldehyde	40-52	albumin	Rattus norvegicus	84-97
316281-1	1979	An inexpensive assay for von Willebrand factor using microtitration plates, formalin-fixed platelets, and ristocetin is described.	Formaldehyde	76-84	von Willebrand factor	Homo sapiens	25-46
117698-1	1979	The authors have developed an improved assay for von Willebrand factor (VIIIVWF) utilizing 4% dimethylsulfoxide (DMSO) to freeze formalin-fixed washed platelets.	Formaldehyde	129-137	von Willebrand factor	Homo sapiens	49-70
389221-1	1979	An immunoperoxidase technique was applied to the localization of IgE in formaldehyde-solution-fixed, paraffin-embedded tissue.	Formaldehyde	72-84	immunoglobulin heavy constant epsilon	Homo sapiens	65-68
499437-4	1979	In further study of these specimens, an immunoperoxidase staining technique was used to stain for hCG in formalin-fixed sections.	Formaldehyde	105-113	chorionic gonadotropin subunit beta 5	Homo sapiens	98-101
231893-1	1979	The ACTH/MSH cells of the pars distalis and pars intermedia of the mammalian hypophysis contain peptides with amino-terminal tryptophan which exhibit a strong fluorescence after treatment with modified formaldehyde vapour methods and with glyoxylic acid in the tissue sections from freeze-dried specimens.	Formaldehyde	202-214	proopiomelanocortin	Homo sapiens	4-8
231893-1	1979	The ACTH/MSH cells of the pars distalis and pars intermedia of the mammalian hypophysis contain peptides with amino-terminal tryptophan which exhibit a strong fluorescence after treatment with modified formaldehyde vapour methods and with glyoxylic acid in the tissue sections from freeze-dried specimens.	Formaldehyde	202-214	proopiomelanocortin	Homo sapiens	9-12
542911-8	1979	It is concluded that the volume of lungs fixed with formaldehyde at a transpulmonary pressure of 25 cmH2O closely approximates to total lung capacity.	Formaldehyde	52-64	troponin T2, cardiac type	Homo sapiens	100-104
93568-2	1979	As an extension of this work, the same approach was used to test for and to localize prolactin binding sites in autopsy and biopsy specimens of formalin fixed, paraffin embedded human prostate.	Formaldehyde	144-152	prolactin	Homo sapiens	85-94
225005-2	1979	Indirect immunofluorescent staining for CEA was carried out on formalin-fixed paraffin-embedded sections, and the slides were examined under code.	Formaldehyde	63-71	CEA cell adhesion molecule 3	Homo sapiens	40-43
573350-2	1979	In antibody negative patients (n = 10) replacement of formaldehyde sterilized dialysers by ethylene-oxide sterilized disposable dialysers resulted in a significant increase (p less than 0.002) of 51Cr t/2 (Mean +/- SD, days: Kiildialyser 16.3 +/- 1.9; disposable dialyser 20.3 +/- 3.5).	Formaldehyde	54-66	calreticulin 3	Homo sapiens	198-204
90174-4	1979	Whereas analysis of living, hybrid virus-infected HeLa cells did not yield conclusive results, analysis of Formalin-fixed cells resulted in positive cell surface fluorescence with both Ad2+ND1- and Ad2+ND2-infected HeLa cells when antisera prepared against sodium dodecyl sulfate-denatured SV40 T-antigen were used as first antibody.	Formaldehyde	107-115	mitochondrially encoded NADH dehydrogenase 1	Homo sapiens	189-192
90174-4	1979	Whereas analysis of living, hybrid virus-infected HeLa cells did not yield conclusive results, analysis of Formalin-fixed cells resulted in positive cell surface fluorescence with both Ad2+ND1- and Ad2+ND2-infected HeLa cells when antisera prepared against sodium dodecyl sulfate-denatured SV40 T-antigen were used as first antibody.	Formaldehyde	107-115	mitochondrially encoded NADH dehydrogenase 2	Homo sapiens	202-205
86522-1	1979	Carcinoembryonic antigen (CEA) was studied by the indirect triple-bridge immunoperoxidase method in formalin-fixed paraffin-embedded tissue specimens from 191 patients with premalignant epithelial lesions or epidermoid carcinoma of the uterine cervix treated 12 years ago.	Formaldehyde	100-108	CEA cell adhesion molecule 3	Homo sapiens	0-24
465171-5	1979	In malnourished children with a high CH2O, antidiuresis showed quite important figures with vasopressin.	Formaldehyde	37-41	arginine vasopressin	Homo sapiens	92-103
378175-1	1979	An indirect immunoperoxidase technique was used to study the content and distribution of IgE in formaldehyde solution-fixed, paraffin-embedded adenoid and nasal tissues of atopic and nonatopic persons.	Formaldehyde	96-108	immunoglobulin heavy constant epsilon	Homo sapiens	89-92
86522-1	1979	Carcinoembryonic antigen (CEA) was studied by the indirect triple-bridge immunoperoxidase method in formalin-fixed paraffin-embedded tissue specimens from 191 patients with premalignant epithelial lesions or epidermoid carcinoma of the uterine cervix treated 12 years ago.	Formaldehyde	100-108	CEA cell adhesion molecule 3	Homo sapiens	26-29
454382-4	1979	Elimination of such competition greatly simplifies the quantitative analysis of the binding process, and permitted a detailed study of the binding to the plasma membrane of formaldehyde-denatured bovine serum albumin, a protein that is rapidly digested within the lysosomal system after its pinocytic capture.	Formaldehyde	173-185	albumin	Rattus norvegicus	203-216
102686-2	1978	Glycosyltransferase activity from roots fixed in buffered formaldehyde or glutaraldehyde before homogenization decreased as the concentration of the fixative or fixation time was increased.	Formaldehyde	58-70	protein O-linked mannose beta 1,4-N-acetylglucosaminyltransferase 2	Mus musculus	0-19
383819-1	1979	Studies were performed in an attempt to improve current immunohistological techniques for the demonstration of alpha 1-antitrypsin (A1AT) in formalin-fixed paraffin-embedded tissues.	Formaldehyde	141-149	serpin family A member 1	Homo sapiens	111-130
383819-1	1979	Studies were performed in an attempt to improve current immunohistological techniques for the demonstration of alpha 1-antitrypsin (A1AT) in formalin-fixed paraffin-embedded tissues.	Formaldehyde	141-149	serpin family A member 1	Homo sapiens	132-136
760368-1	1979	Immunocytochemical localization of GFA protein in formalin-fixed, paraffin-embedded tissue sections by the peroxidase-antiperoxidase method of Sternberger was used to study experimental murine CNS tumors.	Formaldehyde	50-58	glutamine fructose-6-phosphate transaminase 1	Mus musculus	35-38
368433-7	1979	In this study we also carried out indirect immunoferritin and immunoperoxidase electron microscopy for HBc&s Ag on formalin-fixed liver specimens.	Formaldehyde	119-127	keratin 88, pseudogene	Homo sapiens	103-106
572066-3	1979	The drug (Drotaverin: No-Spa) contained in the matrix is released, dependently of the formaldehyde concentration in the matrix, at a predetermined rate.	Formaldehyde	86-98	surfactant protein A2	Homo sapiens	25-28
309339-1	1978	A visual assay of factor VIII-related Willebrand factor (VIIIR:WF) is described which utilizes formaldehyde-fixed platelets, end points being read in microflocculation tiles.	Formaldehyde	95-107	cytochrome c oxidase subunit 8A	Homo sapiens	25-29
572116-0	1979	[The identification of intestinal parasite stages using the merthiolate-iodine-formalin concentration method (MIF-method)].	Formaldehyde	79-87	macrophage migration inhibitory factor	Homo sapiens	110-113
310316-2	1978	Chemical modifications of human plasma alpha1-antitrypsin with reagents which modify lysyl residues (citraconic anhydride, acetic anhydride, formaldehyde and 2,4,6-trinitrobenzenesulfonic acid) and arginyl residued (1,2-cyclohexanedione) were examined with regard to their effect upon the elastase inhibitory capacity of the glycoprotein.	Formaldehyde	141-153	serpin family A member 1	Homo sapiens	39-57
102686-3	1978	Formaldehyde fixation was less inhibitory than glutaraldehyde; 35% of the glycosyltransferase activity was retained after 30 min fixation in 2% formaldehyde while 25% of the enzyme activity remained after a similar fixation in glutaraldehyde.	Formaldehyde	0-12	protein O-linked mannose beta 1,4-N-acetylglucosaminyltransferase 2	Mus musculus	74-93
102686-3	1978	Formaldehyde fixation was less inhibitory than glutaraldehyde; 35% of the glycosyltransferase activity was retained after 30 min fixation in 2% formaldehyde while 25% of the enzyme activity remained after a similar fixation in glutaraldehyde.	Formaldehyde	144-156	protein O-linked mannose beta 1,4-N-acetylglucosaminyltransferase 2	Mus musculus	74-93
102686-4	1978	Substantially higher levels of L1210 cell glycosyltransferase activity were retained after a 30 min 2% formaldehyde fixation (60% sialyltransferase; 82% galactosyltransferase), but inhibition by glutaraldehyde was similar to that observed for onion root galactosyltransferase.	Formaldehyde	103-115	protein O-linked mannose beta 1,4-N-acetylglucosaminyltransferase 2	Mus musculus	42-61
102686-5	1978	Glycosyltransferase from formaldehyde-fixed roots was inhbited 35% by lead nitrate, but sialytransferase from formaldehyde-fixed L1210 cells was unaffected by lead ions.	Formaldehyde	25-37	protein O-linked mannose beta 1,4-N-acetylglucosaminyltransferase 2	Mus musculus	0-19
361205-1	1978	Carcinoembryonic antigen (CEA) was demonstrated in formalin-fixed paraffin embedded sections of normal small intestine using an immunoperoxidase method.	Formaldehyde	51-59	CEA cell adhesion molecule 3	Homo sapiens	0-30
249314-7	1978	Radioactively labeled [14C]Co-EIF-1 was prepared by reductive alkylation using [14C]formaldehyde and borohydride.	Formaldehyde	84-96	eukaryotic translation initiation factor 1	Oryctolagus cuniculus	30-35
209658-1	1978	Eighty glial and non-glial brain tumors have been studied to date using an immunologically specific and highly sensitive method of staining GFA protein which is applicable to formalin fixed and paraffin embedded tissue.	Formaldehyde	175-183	glutamine--fructose-6-phosphate transaminase 1	Homo sapiens	140-143
568065-0	1978	The disposition of formaldehyde and formate arising from drug N-demethylations dependent on cytochrome P-450 in hepatocytes and in perfused rat liver.	Formaldehyde	19-31	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	92-108
211503-1	1978	Formaldehyde-fixed Staphylococcus aureus and monospecific antiserum to gp70, the major envelope glycoprotein of murine leukemia virus, were used to immunoadsorb gp70 from Nonidet P40 extracts prepared from surface-radioiodinated murine cells.	Formaldehyde	0-12	embigin	Mus musculus	161-165
359571-4	1978	Antisera to H2B, H3 and H4, when reacted with either formaldehyde- or acetic acid-fixed chromosomes, produce distinct banding patterns closely resembling the banding of acetoorcein-stained or phase-contrast-differentiated chromosomal preparations.	Formaldehyde	53-65	histone H2B type 2-E	Bos taurus	12-26
211682-1	1978	A study was made of the effect of procedures (freezing-thawing prior to incubation, prefixation with formaldehyde and glutaraldehyde, incubation with DMSO) on the activity of ATPase and beta-glycerophosphatase in leucocytes and erythrocytes of man, and of the effect of these procedures and of homogenization on ATPase activity in the cells of the rat thymus.	Formaldehyde	101-113	dynein axonemal heavy chain 8	Homo sapiens	175-181
80847-4	1978	Staining procedure: wash formalin-fixed brain slices overnight in running tap water.	Formaldehyde	25-33	nuclear RNA export factor 1	Homo sapiens	74-77
218778-4	1978	The level of ceruloplasmin was markedly increased after formalin arthritis, after ACTH treatment in controls and in adrenalectomized animals.	Formaldehyde	56-64	ceruloplasmin	Rattus norvegicus	13-26
348269-2	1978	We used the peroxidase-antiperoxidase immunohistochemical method to demonstrate the localization of choline acetyltransferase in formalin-fixed and paraffin-embedded sections of rabbit spinal cord and cerebellum.	Formaldehyde	129-137	LOW QUALITY PROTEIN: choline O-acetyltransferase	Oryctolagus cuniculus	100-125
648742-9	1978	Incubations with monomeric ferritin-insulin at 4 degrees or with tissue prefixed with formaldehyde showed that the groups of insulin receptors were naturally occurring, i.e., they are present prior to and independent of insulin binding and thus not secondary to ligand-induced aggregation.	Formaldehyde	86-98	insulin	Homo sapiens	125-132
648742-9	1978	Incubations with monomeric ferritin-insulin at 4 degrees or with tissue prefixed with formaldehyde showed that the groups of insulin receptors were naturally occurring, i.e., they are present prior to and independent of insulin binding and thus not secondary to ligand-induced aggregation.	Formaldehyde	86-98	insulin	Homo sapiens	125-132
565874-1	1978	Even a small amount of formaldehyde is shown to induce a drop in the RNase A enzymatic activity.	Formaldehyde	23-35	ribonuclease A family member 1, pancreatic	Homo sapiens	69-76
565874-4	1978	Comparison of the effects of formaldehyde on the enzymatic and the destabilizing activity of RNase A was made.	Formaldehyde	29-41	ribonuclease A family member 1, pancreatic	Homo sapiens	93-100
369084-3	1978	It thus appears that the incidence of positive CEA by immunoperoxidase staining of formalin-fixed, paraffin-embedded tumour tissue sections is much less than the frequency of blood or urinary CEA elevations in patients with urothelial cancer.	Formaldehyde	83-91	CEA cell adhesion molecule 3	Homo sapiens	47-50
339969-2	1977	This contrast allows accurate identification of fluorescent CSF cells and structures in formalin fixed paraffin embedded brain tissues; in the latter, the combined optical procedure is fruitfull in order to avoid fluorescent artifacts misinterpretation.	Formaldehyde	88-96	colony stimulating factor 2	Homo sapiens	60-63
751346-3	1978	The deparaffinized sections are again treated with formalin in order to make the "unmasked" by the delipidization basic groups of MBP reactive to ammoniacal silver.	Formaldehyde	51-59	myelin basic protein	Homo sapiens	130-133
564692-6	1977	Uptake of formaldehyde-treated 125I-labelled bovine serum albumin was followed by the release of [125I]iodo-L-tyrosine into the culture medium and took place at a rate intermediate between those of collodial [198Au]gold and the other two non-digestible substrates, 125I-labelled poly(vinylpyrrolidone) and [14C]sucrose.	Formaldehyde	10-22	albumin	Rattus norvegicus	52-65
880431-4	1977	The inclusion of the oxymethylene link promotes selectivity for beta1-as opposed to beta2-adrenoceptor activity.	Formaldehyde	21-33	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	64-69
200365-0	1977	Formaldehyde-ozone-induced fluorescence in pituitary ACTH cells: effect of adrenalectomy.	Formaldehyde	0-12	proopiomelanocortin	Homo sapiens	53-57
19545-1	1977	Platelet-aggregating factor (PAF) was removed from bovine plasma by human platelets fixed with 2% formaldehyde.	Formaldehyde	98-110	PCNA-associated factor	Bos taurus	0-27
19545-1	1977	Platelet-aggregating factor (PAF) was removed from bovine plasma by human platelets fixed with 2% formaldehyde.	Formaldehyde	98-110	PCNA-associated factor	Bos taurus	29-32
408228-1	1977	Eighteen Adh-negative mutations were selected with 1-pentyn-3-ol after feeding of formaldehyde.	Formaldehyde	82-94	Alcohol dehydrogenase	Drosophila melanogaster	9-12
144099-2	1977	Pretreatment of frozon cryostat sections with formaldehyde or calcium ions inhibits diffusion of the plasma membrane enzymes 5" nucleotidase, ATP-ase and alkaline phosphatase during incubation.	Formaldehyde	46-58	dynein axonemal heavy chain 8	Homo sapiens	142-149
338442-1	1977	An immunoperoxidase method for the demonstration of carcinoembryonic antigen (CEA) in tissues was applied to formalin-fixed paraffin embedded and glutaraldehyde-fixed resin sections of normal human small intestine.	Formaldehyde	109-117	CEA cell adhesion molecule 3	Homo sapiens	78-81
880431-4	1977	The inclusion of the oxymethylene link promotes selectivity for beta1-as opposed to beta2-adrenoceptor activity.	Formaldehyde	21-33	adrenoceptor beta 2	Homo sapiens	84-102
411214-3	1977	A suitable method was developed and proposed for diagnostic purposes; the method consists of double fixation, 1.25% glutaraldehyde in phosphate buffer, or the formaldehyde fixative PAF (Stefanini et al., 1967), being used for the first fixation, and 1% osmium tetroxide (OsO4) after Caulfied (1957) being used for postfixation.	Formaldehyde	159-171	PCNA clamp associated factor	Homo sapiens	181-184
557348-0	1977	Uptake and degradation of formaldehyde-treated 125I-labelled human serum albumin in rat liver cells in vivo and in vitro.	Formaldehyde	26-38	albumin	Rattus norvegicus	73-80
870513-10	1977	Aqueous vasopressin, 50 mU (containing in 25 mg of ovine prolactin), produced a decrease in CH2O not significantly different from prolactin in 6 water loaded subjects.	Formaldehyde	92-96	arginine vasopressin	Homo sapiens	8-19
870513-10	1977	Aqueous vasopressin, 50 mU (containing in 25 mg of ovine prolactin), produced a decrease in CH2O not significantly different from prolactin in 6 water loaded subjects.	Formaldehyde	92-96	prolactin	Homo sapiens	57-66
557348-1	1977	The uptake of formaldehyde-treated 125I-labelled human serum albumin in rat hepatocytes and nonparenchymal liver cells was measured in vivo and in vitro.	Formaldehyde	14-26	albumin	Rattus norvegicus	61-68
321699-1	1977	Treatment of dewaxed sections of formalin-fixed paraffin embedded material with 0.1% pronase for 15 min at 37 degrees C prior to the performance of the unlabelled antibody-enzyme (PAP) procedure greatly enhanced its sensitivity.	Formaldehyde	33-41	regenerating family member 3 alpha	Homo sapiens	180-183
190273-0	1977	Detection of pregnancy specific beta1-glycoprotein in formalin-fixed tissues.	Formaldehyde	54-62	pregnancy specific beta-1-glycoprotein 10, pseudogene	Homo sapiens	13-50
190273-1	1977	Using an enzyme-bridge immunoperoxidase method, pregnancy specific beta1-glycoprotein (PSbetaG) has been demonstrated in the cytoplasm of the trophoblast in several formalin-fixed tissues, namely, implantation sites of ovum, normal placentae, hydatidiform moles, invasive moles, and choriocarcinomata of uterus and testis.	Formaldehyde	165-173	pregnancy specific beta-1-glycoprotein 10, pseudogene	Homo sapiens	48-85
190273-1	1977	Using an enzyme-bridge immunoperoxidase method, pregnancy specific beta1-glycoprotein (PSbetaG) has been demonstrated in the cytoplasm of the trophoblast in several formalin-fixed tissues, namely, implantation sites of ovum, normal placentae, hydatidiform moles, invasive moles, and choriocarcinomata of uterus and testis.	Formaldehyde	165-173	pregnancy specific beta-1-glycoprotein 10, pseudogene	Homo sapiens	87-94
319818-2	1977	CEA was demonstrated in a higher percentage of the polyps received as fresh specimens that were rapidly frozen and fixed in ethanol, than in formalin-fixed, paraffin-embedded sections.	Formaldehyde	141-149	CEA cell adhesion molecule 3	Homo sapiens	0-3
62099-1	1976	The purpose of this study was to explore a method by which an improved immunofluorescent staining can be applied to formalin-fixed paraffin sections to demonstrate cellular or tissue deposits of immunoglobulins, complement and fibrin, and to demonstrate alpha-1-antitrypsin storage and hepatitis B antigens in liver, toxoplasma in heart, and carcinoembryonic antigens in colonic cancer.	Formaldehyde	116-124	adrenoceptor alpha 1D	Homo sapiens	254-261
62740-5	1976	When a fixative mixture of methanol:acetic acid:formalin (85:5:10 by volume; MAF) is used, the concentration of nuclear solids during NYS staining remain at a physiological level of 19 per cent.	Formaldehyde	48-56	MAF bZIP transcription factor	Homo sapiens	77-80
63319-3	1976	An indirect immunoperoxidase method for the localization of human chorionic gonadotropin (HCG) and alpha-fetoprotein (AFP) was done on formalin-fixed paraffin-embedded tissue from 10 neoplasms; HCG was present in all 10 neoplasms, and AFP was found in seven.	Formaldehyde	135-143	alpha fetoprotein	Homo sapiens	118-121
993925-6	1976	Delivery of fluid from the proximal tubule (CH2O =Na per dl GFR) increased (p less than 0.005).	Formaldehyde	44-48	Rap guanine nucleotide exchange factor 5	Homo sapiens	60-63
955977-3	1976	In addition to AChE activity, the bundles of fibers of this network also show a strong formaldehyde-induced NA fluorescence.	Formaldehyde	87-99	acetylcholinesterase	Cavia porcellus	15-19
794493-5	1976	CEA could be detected in ethanol- or formalin-fixed sections.	Formaldehyde	37-45	CEA cell adhesion molecule 3	Homo sapiens	0-3
794493-8	1976	An analysis of the formalin-paraffin-treated sections showed that immunoperoxidase-tested CEA positivity reflected CEA levels in tissue of at least 3.0-5.0 mug/g; this permitted retrospective estimates of minimal tissue CEA concentrations in older histopathologic specimens by the immunoperoxidase reaction method.	Formaldehyde	19-27	CEA cell adhesion molecule 3	Homo sapiens	90-93
794493-9	1976	Formalin-paraffin-treated sections as old as 10 years still had demonstrable CEA.	Formaldehyde	0-8	CEA cell adhesion molecule 3	Homo sapiens	77-80
818909-5	1976	EDTA-treated, Formalin-fixed, washed normal platelets also underwent vWF-mediated agglutination.	Formaldehyde	14-22	von Willebrand factor	Homo sapiens	69-72
1265771-10	1976	The results of these studies reveal important differences between the properties of the enzymatic systems which metabolize DMN and mixed function oxidase substrates, and are consistent with the conclusion that the degradation of DMN to formaldehyde by rat liver preparations is a multicomponent system not rate limiting with respect to cytochrome P-450.	Formaldehyde	236-248	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	336-352
176156-0	1976	Biochemical properties of rat liver mitochondrial aldehyde dehydrogenase with respect to oxidation of formaldehyde.	Formaldehyde	102-114	aldehyde dehydrogenase 2 family member	Rattus norvegicus	36-72
775322-4	1976	Strains defective (rad 1-3) or with a reduced capacity (p-, cytoplasmic respiratory deficient mutants) in excision repair of ultraviolet-induced pyrimidine dimers show a greater sensitivity to formaldehyde than the corresponding wild type.	Formaldehyde	193-205	ssDNA endodeoxyribonuclease RAD1	Saccharomyces cerevisiae S288C	19-24
943675-2	1976	The existence and specificity of these sites were demonstrated by competition for binding to unfixed oocyte membrane fragments and by displacement of already bound and labeled phosvitin-lipovitellin from formaldehyde-fixed membranes.	Formaldehyde	204-216	Casein kinase II subunit beta	Gallus gallus	176-185
7280-4	1976	After addition of an NADPH-regenerating system to liver microsomes isolated from adult female Wistar rats, the oxidative N-demethylation of aminopyrine was measured under simultaneous exposure to CS2 by quantitatively determining the formaldehyde obtained; the resulting data were evaluated using enzyme-kinetic parameters according to Lineweaver-Burk: 1.	Formaldehyde	234-246	calsyntenin 2	Rattus norvegicus	196-199
7280-21	1976	In substrate-free control mixtures, addition of CS2 was followed by the dose-dependent formation of formaldehyde; a causal explanation is not readily available at this time.	Formaldehyde	100-112	calsyntenin 2	Rattus norvegicus	48-51
1239827-1	1975	Low concentrations of Evans Blue (less than 1 muM) inhibit the agglutination of formalin-treated platelets by bovine Factor VIII or by human Factor VIII in the presence of the antibiotic ristocetin.	Formaldehyde	80-88	coagulation factor VIII	Bos taurus	117-128
1029022-1	1976	Rapid and progressive inactivation in vitro of both alcohol dehydrogenase and aldehyde dehydrogenase by low concentrations of acetaldehyde or formaldehyde is illustrated.	Formaldehyde	142-154	aldo-keto reductase family 1 member A1	Homo sapiens	52-73
1239827-1	1975	Low concentrations of Evans Blue (less than 1 muM) inhibit the agglutination of formalin-treated platelets by bovine Factor VIII or by human Factor VIII in the presence of the antibiotic ristocetin.	Formaldehyde	80-88	coagulation factor VIII	Bos taurus	141-152
1237519-4	1975	This immunocytochemical method for demonstrating the presence of CEA functioned in both frozen, ethanol-fixed and formalin-fixed, paraffin-embedded tissues, thus making it applicable for use with tissue sections conventionally prepared for light microscopy.	Formaldehyde	114-122	CEA cell adhesion molecule 3	Homo sapiens	65-68
55476-1	1975	A method is described, combining immunohistochemistry and histological staining methods in the same section, for the identification of ACTH- and STH-producing cells in formalin-fixed, routine processed human pituitary tissue.	Formaldehyde	168-176	proopiomelanocortin	Homo sapiens	135-139
55476-1	1975	A method is described, combining immunohistochemistry and histological staining methods in the same section, for the identification of ACTH- and STH-producing cells in formalin-fixed, routine processed human pituitary tissue.	Formaldehyde	168-176	saitohin	Homo sapiens	145-148
1150325-6	1975	Treatment of cell culture-propagated rickettsiae with formalin or germicidal ultraviolet radiation induced a total shift of the less dense cell population to a zone of higher density when centrifuged isopycnically in CsC1 gradients.	Formaldehyde	54-62	transmembrane protein 63C	Homo sapiens	217-221
1102500-4	1975	In models neither of the hormones tested--GH, gastrin, insulin--gave fluorescamine-induced fluorescence after pretreatment with formaldehyde.	Formaldehyde	128-140	insulin	Homo sapiens	55-62
807600-3	1975	Platelets treated with formalin were not aggregated by ADP, thrombin, or collagen, but were agglutinated by bovine Factor VIII, although they did not show super-aggregation.	Formaldehyde	23-31	coagulation factor II, thrombin	Bos taurus	60-68
807600-3	1975	Platelets treated with formalin were not aggregated by ADP, thrombin, or collagen, but were agglutinated by bovine Factor VIII, although they did not show super-aggregation.	Formaldehyde	23-31	coagulation factor VIII	Bos taurus	115-126
1092586-4	1975	Antral and duodenal gastrin cells, as well as pancreatic A2-cells, displayed strong formaldehyde- ozone- and formaldehyde-HCl-induced fluorescence, whereas the pancreatic A1-cells (claimed to store gastrin) were nonfluorescent.	Formaldehyde	84-96	gastrin	Homo sapiens	20-27
1095534-0	1975	Formaldehyde-ozone-induced fluorescence in isolated gastrin granules.	Formaldehyde	0-12	gastrin	Homo sapiens	52-59
1095534-1	1975	In several mammals the antral gastrin cells display characteristic formaldehyde-ozone-induced fluorescence (375/500-520 nm).	Formaldehyde	67-79	gastrin	Homo sapiens	30-37
1095534-3	1975	Gastrin granules, isolated from gastrinomas and identified by immunofluorescence and electron microscopy, were found to show intense formaldehyde-ozone-induced fluorescence.	Formaldehyde	133-145	gastrin	Homo sapiens	0-7
1113-5	1975	The results of formalinization experiments demonstrate that high concentrations of formaldehyde dissociate PFK u to the 5.3 S component.	Formaldehyde	83-95	ATP-dependent 6-phosphofructokinase, muscle type	Oryctolagus cuniculus	107-110
1095822-1	1975	An immunohistochemical staining to demonstrate the hepatitis B core and surface antigens (HBc&sAg) on formalin-fixed, paraffin-embedded liver tissue was investigated.	Formaldehyde	106-114	keratin 88, pseudogene	Homo sapiens	90-93
1095822-1	1975	An immunohistochemical staining to demonstrate the hepatitis B core and surface antigens (HBc&sAg) on formalin-fixed, paraffin-embedded liver tissue was investigated.	Formaldehyde	106-114	S-antigen visual arrestin	Homo sapiens	98-101
1095822-5	1975	The immunoreactive sites of HBc&s Ag are shown to be preserved in the formalin-fixed, paraffin-embedded tissue, and they can be demonstrated by either direct or indirect immunofluorescent and immunoperoxidase methods.	Formaldehyde	74-82	keratin 88, pseudogene	Homo sapiens	28-31
238843-1	1975	The amino groups of ribonuclease A (RNase-A) have been methylated with formaldehyde and borohydride to provide observable resonances for proton magnetic resonance (PMR) studies.	Formaldehyde	71-83	ribonuclease A family member 1, pancreatic	Homo sapiens	20-34
238843-1	1975	The amino groups of ribonuclease A (RNase-A) have been methylated with formaldehyde and borohydride to provide observable resonances for proton magnetic resonance (PMR) studies.	Formaldehyde	71-83	ribonuclease A family member 1, pancreatic	Homo sapiens	36-43
168283-10	1975	Furthermore, specific uptake of HPL was observed on the alveolar cell membranes after the incubation of paraffin-embedded sections of formalin-fixed mammary gland and subsequent treatment by the peroxidase-labelled antibody method.	Formaldehyde	134-142	galectin 1	Homo sapiens	32-35
1092586-4	1975	Antral and duodenal gastrin cells, as well as pancreatic A2-cells, displayed strong formaldehyde- ozone- and formaldehyde-HCl-induced fluorescence, whereas the pancreatic A1-cells (claimed to store gastrin) were nonfluorescent.	Formaldehyde	109-121	gastrin	Homo sapiens	20-27
1090367-12	1975	These data indicate that formaldehyde fixation selectively impaired the H-2 antigens, leaving the viral antigenicity relatively intact.	Formaldehyde	25-37	histocompatibility-2, MHC	Mus musculus	72-75
238082-1	1975	Quantitative microfluorimetric studies were carried out on the formaldehyde induced fluorescence of dopamine in nerve terminals of the nuc.	Formaldehyde	63-75	nucleobindin 1	Homo sapiens	135-138
1120786-13	1975	The effect of insulin on CH2O suggests that insulin"s effect on sodium excretion is due to enhancement of sodium reabsorption in the diluting segment of the distal nephron.	Formaldehyde	25-29	insulin	Homo sapiens	14-21
1120786-13	1975	The effect of insulin on CH2O suggests that insulin"s effect on sodium excretion is due to enhancement of sodium reabsorption in the diluting segment of the distal nephron.	Formaldehyde	25-29	insulin	Homo sapiens	44-51
238082-9	1975	It may be concluded that by using microfluorimetric quantitation of the formaldehyde induced fluorescence in the nuc.	Formaldehyde	72-84	nucleobindin 1	Homo sapiens	113-116
47826-3	1975	Samples of formalin-treated PIV-3 released more N-acteylneuraminic acid (NANA) than samples of Piv-3 not treated with formalin when these samples were incubated with the substrate sialolactose for 16 h at 37 degrees C. The initial activity of PIV-3 NA, and the Km-value, were similar for a NAS strain whether it was treated with formalin or not.	Formaldehyde	11-19	neuraminidase 1	Bos taurus	73-75
1227350-5	1975	Hydrogen peroxyde oxidizes in the presence of catalase inethanol to formaldehyde which gives with ammonium ions and acetylacetone 3-5 diacetyl 1-4 dihydrolutidine measured by fluorimetry.	Formaldehyde	68-80	catalase	Homo sapiens	46-54
241628-2	1975	In static tests at pH 4.5, chelates of Mn(II), Fe(II) and Co(II) photodegraded to give 14CO2 and CH2O.	Formaldehyde	97-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-64
47826-4	1975	The results suggest that formalin stabilized the NA structure of PIV-3.	Formaldehyde	25-33	neuraminidase 1	Bos taurus	49-51
4139160-7	1974	Papain-digested univalent antibodies (Fab) coupled with peroxidase were used to label rhodopsin in formaldehyde-fixed bovine and murine retinas.	Formaldehyde	99-111	rhodopsin	Bos taurus	86-95
1126622-7	1975	Using this procedure and formaldehyde to generate mutants, we were able to detect seven alcohol dehydrogenase negative mutants out of 350,000 individuals subjected to selection.	Formaldehyde	25-37	Alcohol dehydrogenase	Drosophila melanogaster	88-109
804748-0	1975	Formaldehyde-ozone-induced fluorescence in gastrin-producing tumours.	Formaldehyde	0-12	gastrin	Homo sapiens	43-50
4426701-9	1974	Lysozyme adsorption by formalin-killed spherules in the presence of varying concentrations of calcium ion and the rapid alteration of permeability seen after lysozyme treatment suggested that the cell membrane was damaged as a result of binding lysozyme.	Formaldehyde	23-31	lysozyme	Homo sapiens	0-8
4588962-0	1973	Immunofluorescent localization of gastrin in rabbit antropyloric mucosa to argyrophil cells exhibiting formaldehyde-ozone-induced fluorescence.	Formaldehyde	103-115	gastrin	Oryctolagus cuniculus	34-41
4609614-0	1974	Concomitant development of gastrin immunoreactivity and formaldehyde-ozone-induced fluorescence in gastrin cells of rabbit antropyloric mucosa.	Formaldehyde	56-68	gastrin	Oryctolagus cuniculus	99-106
4856714-4	1974	When Formalin-treated red blood cells were sensitized with this antitoxin, the antibodies coupled to the cells were, for practical results, only anti-Abeta.	Formaldehyde	5-13	amyloid beta precursor protein	Homo sapiens	150-155
18557242-9	1972	The lower CH2O: GFR ratios imply a selective distal tubular damage.	Formaldehyde	10-14	Rap guanine nucleotide exchange factor 5	Homo sapiens	16-19
4703229-4	1973	The vasopressin-stimulated movement of formaldehyde and thiourea is also reduced.	Formaldehyde	39-51	arginine vasopressin	Homo sapiens	4-15
4667544-0	1972	[Effectiveness of anti-foot-and-mouth disease GOA-formol vaccine with saponin].	Formaldehyde	50-56	tripartite motif containing 47	Homo sapiens	46-49
4196693-0	1973	Lactase and other enzymes bound to a phenol-formaldehyde resin with glutaraldehyde.	Formaldehyde	44-56	lactase	Homo sapiens	0-7
4100877-0	1970	Reaction of formaldehyde with viral MS2-RNA at low pH.	Formaldehyde	12-24	MS2	Homo sapiens	36-39
4553241-0	1972	[Dynamics of changes caused by tricresol-formalin in the cells of HEp line examined with the phase contrast microscope].	Formaldehyde	41-49	DNL-type zinc finger	Homo sapiens	66-69
4166251-0	1966	[Production of local tissue changes in mice typical for Whipple"s disease using human SPC material fixed in formalin].	Formaldehyde	108-116	proline rich protein gene cluster	Homo sapiens	86-89
4186252-0	1969	Light microscopic study of the peroxidatic activity of catalase in formaldehyde-fixed rat liver.	Formaldehyde	67-79	catalase	Rattus norvegicus	55-63
4980717-9	1969	The red colour is probably formed by reaction of the lysine in-amino groups of bovine serum albumin, as it is prevented by treating the protein with formaldehyde, succinic anhydride or O-methylisourea.	Formaldehyde	149-161	albumin	Homo sapiens	86-99
4289222-2	1966	Formalin inactivated OCT-wild strain vaccine.	Formaldehyde	0-8	plexin A2	Homo sapiens	21-24
4389806-0	1969	[Demonstration of catalase inhibition by formaldehyde in vitro].	Formaldehyde	41-53	catalase	Homo sapiens	18-26
4302462-0	1968	Preservation of glucose 6-phosphatase activity in formaldehyde-fixed fresh frozen sections.	Formaldehyde	50-62	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	16-37
14336192-0	1965	HISTOCHEMICAL SURVIVAL OF DIAPHORASE ACTIVITY IN FORMALIN-FIXED TISSUES STORED FOR 18 MONTHS IN COLD GUM-SUCROSE.	Formaldehyde	49-57	dihydrolipoamide dehydrogenase	Homo sapiens	26-36
14086144-0	1963	DEMONSTRATION OF MITOCHONDRIAL ATPASE ACTIVITY IN FORMALIN-FIXED COLONIC EPITHELIAL CELLS.	Formaldehyde	50-58	ATP synthase F1 subunit epsilon	Homo sapiens	17-37
14222810-4	1964	Cholinesterase activity in formalin-fixed heart muscle was localized: (a) in longitudinal elements of the sarcoplasmic reticulum, but not in the T, or transverse, elements; and (b) in the A band, with virtually no activity noted in the M band, or in the H zone.	Formaldehyde	27-35	butyrylcholinesterase	Rattus norvegicus	0-14
14228524-2	1964	ATPase was demonstrated in the metaphase spindle of HeLa and Sarcoma 180 cells fixed in cold buffered 2 per cent formalin (pH 6.5 to 6.8) containing 2 x 10(-3)M CaCl(2).	Formaldehyde	113-121	dynein axonemal heavy chain 8	Homo sapiens	0-6
14228524-6	1964	In polar views of Sarcoma 180 cells fixed in cold, unbuffered, 2 per cent formalin, ATPase was frequently localized in granules in the region of the inner circumference of the ring of chromosomes formed at metaphase.	Formaldehyde	74-82	dynein, axonemal, heavy chain 8	Mus musculus	84-90
13967676-0	1962	Application of fluorescence microscopy to the study of possible insulin-binding reactions in formalin-fixed material.	Formaldehyde	93-101	insulin	Homo sapiens	64-71
14069691-0	1963	[PROBLEMS OF OCCUPATIONAL HYGIENE IN THE PRODUCTION OF 100 PER CENT SYNTHETIC RESINS MANUFACTURED USING P-TERT-BUTYLPHENOL AND FORMALDEHYDE AS THE BASE].	Formaldehyde	127-139	telomerase reverse transcriptase	Homo sapiens	106-110
13566142-0	1958	Formaldehyde as an acceptor aldehyde for transketolase, and the biosynthesis of triose.	Formaldehyde	0-12	transketolase	Homo sapiens	41-54
13791446-0	1960	The dismutation of formaldehyde by liver alcohol dehydrogenase.	Formaldehyde	19-31	aldo-keto reductase family 1 member A1	Homo sapiens	41-62
13587919-2	1958	The digestion of rhodopsin by chymotrypsin was measured by the hydrolysis of peptide bonds (formol titration), changes in pH, and bleaching.	Formaldehyde	92-98	rhodopsin	Bos taurus	17-26
13397590-0	1956	[Effect of formaldehyde on methemoglobin degeneration in erythrocytes].	Formaldehyde	11-23	hemoglobin subunit gamma 2	Homo sapiens	27-40
13525986-1	1958	I. Quantitative chemical determinations in formaldehyde preserved brains as an aid in the neuropathology of demyelinating conditions and lipidoses.	Formaldehyde	43-55	activation induced cytidine deaminase	Homo sapiens	79-82
13305010-0	1956	[Antigenic properties of formol-and heat-treated crystallized horse serum albumin].	Formaldehyde	25-31	albumin	Homo sapiens	74-81
13597453-0	1958	[Titration of bovine serum albumin in urea and in formaldehyde solutions].	Formaldehyde	50-62	albumin	Homo sapiens	21-34
14831024-2	1951	The reaction to form RDX from ammonium nitrate and formaldehyde in acetic anhydride.	Formaldehyde	51-63	radixin	Homo sapiens	21-24
14378154-2	1955	Reaction between formaldehyde and methemoglobin].	Formaldehyde	17-29	hemoglobin subunit gamma 2	Homo sapiens	34-47
14378187-0	1955	[Quantitative determination of formaldehyde in qualitative evaluation of the pancreas used for preparation of insulin].	Formaldehyde	31-43	insulin	Homo sapiens	110-117
14821504-0	1951	The effect of ACTH, cortisone, and DCA with ascorbic acid on "formalin-arthritis".	Formaldehyde	62-70	proopiomelanocortin	Homo sapiens	14-18
13023629-0	1952	[Effect of formaldehyde on activity of various preparations of cholinesterase].	Formaldehyde	11-23	butyrylcholinesterase	Homo sapiens	63-78
14825146-0	1951	Formaldehyde as an inhibitor of clotting of fibrinogen by thrombin.	Formaldehyde	0-12	coagulation factor II, thrombin	Homo sapiens	58-66
18894930-0	1948	The mechanism of the clotting of fibrinogen with formaldehyde and quinone; interactions between formaldehyde and thrombin.	Formaldehyde	49-61	fibrinogen beta chain	Homo sapiens	33-43
32857249-3	2021	We carried out a preliminary evaluation of MYB-NFIB translocation by fluorescence in-situ hybridization on seven archived formalin-fixed paraffin-embedded tissues of AdCC of Nigerian patients and its clinicopathologic features.	Formaldehyde	122-130	MYB proto-oncogene, transcription factor	Homo sapiens	43-46
33714857-9	2021	Although the use of FALDH resulted in the increase in the sensor output from aldehydes, such as acetaldehyde and formaldehyde, considering their concentrations in body fluids, the influence on the sensor output is limited.	Formaldehyde	113-125	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	20-25
18894930-0	1948	The mechanism of the clotting of fibrinogen with formaldehyde and quinone; interactions between formaldehyde and thrombin.	Formaldehyde	96-108	fibrinogen beta chain	Homo sapiens	33-43
32857249-3	2021	We carried out a preliminary evaluation of MYB-NFIB translocation by fluorescence in-situ hybridization on seven archived formalin-fixed paraffin-embedded tissues of AdCC of Nigerian patients and its clinicopathologic features.	Formaldehyde	122-130	nuclear factor I B	Homo sapiens	47-51
33675098-3	2021	Here, we performed mutation-specific RNA in situ hybridization to evaluate mutant allele expression of KRAS p.G12V, the most frequently detected mutation in ovarian endometriosis in our previous study, in formalin-fixed paraffin-embedded tissue (FFPE) samples of ovarian endometriosis, cancer cell lines, and ovarian cancers.	Formaldehyde	205-213	KRAS proto-oncogene, GTPase	Homo sapiens	103-107
33729593-9	2021	We used male mice with Erk5 deletion specifically in the CNS and found that Erk5 plays important roles in central sensitization in a formalin-induced inflammatory pain model.	Formaldehyde	133-141	mitogen-activated protein kinase 7	Mus musculus	76-80
33400181-8	2021	Our bioinformatics analysis revealed that the oxidative stress genes superoxide dismutase (SOD1, SOD2) and the pro-inflammatory marker tumor necrosis factor (TNF) were identified as the top relevant genes, and the folate metabolism, vitamin B12 metabolism, and the ALS pathways were highly affected by formaldehyde and related to the most brain diseases of interest.	Formaldehyde	302-314	superoxide dismutase 1	Homo sapiens	91-95
33400181-8	2021	Our bioinformatics analysis revealed that the oxidative stress genes superoxide dismutase (SOD1, SOD2) and the pro-inflammatory marker tumor necrosis factor (TNF) were identified as the top relevant genes, and the folate metabolism, vitamin B12 metabolism, and the ALS pathways were highly affected by formaldehyde and related to the most brain diseases of interest.	Formaldehyde	302-314	superoxide dismutase 2	Homo sapiens	97-101
33400181-8	2021	Our bioinformatics analysis revealed that the oxidative stress genes superoxide dismutase (SOD1, SOD2) and the pro-inflammatory marker tumor necrosis factor (TNF) were identified as the top relevant genes, and the folate metabolism, vitamin B12 metabolism, and the ALS pathways were highly affected by formaldehyde and related to the most brain diseases of interest.	Formaldehyde	302-314	tumor necrosis factor	Homo sapiens	135-156
33400181-8	2021	Our bioinformatics analysis revealed that the oxidative stress genes superoxide dismutase (SOD1, SOD2) and the pro-inflammatory marker tumor necrosis factor (TNF) were identified as the top relevant genes, and the folate metabolism, vitamin B12 metabolism, and the ALS pathways were highly affected by formaldehyde and related to the most brain diseases of interest.	Formaldehyde	302-314	tumor necrosis factor	Homo sapiens	158-161
33290179-7	2021	METHODS: mIF staining was performed with formalin-fixed, paraffin-embedded slides from 10 patients with iLTS who underwent cricotracheal resection and 10 control specimens derived from rapid autopsy for CD4, CD8, CD20, FoxP3, PD-1, PD-L1, and cytokeratin.	Formaldehyde	41-49	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	9-12
34050137-4	2021	Using 150 formalin-fixed and paraffin-embedded samples and 8 fresh samples, we found high PNO1 expression in HCC tumor tissues through Western blotting and RT-PCR.	Formaldehyde	10-18	partner of NOB1 homolog	Homo sapiens	90-94
33650598-5	2021	We show that water is unlikely to be important in this stage of the process, C-H bonds of C2 and C3 species can give an energetically favourable pathway and that the disproportionation of hydroxymethyl radicals to methanol and formaldehyde produces a very favourable route.	Formaldehyde	227-239	complement C2	Homo sapiens	90-99
33368602-4	2021	METHODS/RESULTS: Expression of MUC4 was assessed by immunohistochemistry in a total of 97 rhabdomyosarcomas using formalin-fixed paraffin-embedded tissue sections.	Formaldehyde	114-122	mucin 4, cell surface associated	Homo sapiens	31-35
34059899-4	2021	Formaldehyde cross-linked the fluorescein isothiocyanate (FITC)-tagged Medicago group 1 CEP (MtCEP1) to wild-type Medicago or Arabidopsis vascular tissue cells, but not to the CEP receptor mutants, cra2 or cepr1.	Formaldehyde	0-12	Leucine-rich repeat transmembrane protein kinase family protein	Arabidopsis thaliana	206-211
34058181-0	2021	CdO-ZnO nanorices for enhanced and selective formaldehyde gas sensing applications.	Formaldehyde	45-57	cell adhesion associated, oncogene regulated	Homo sapiens	0-3
34058181-5	2021	The fabricated gas sensor based on CdO-ZnO nanorices exhibited a high response (34.5) towards 300 ppm formaldehyde gas at 350  C compared to ZnO nanoflowers (14.5) under the same experimental conditions.	Formaldehyde	102-114	cell adhesion associated, oncogene regulated	Homo sapiens	35-38
34058181-7	2021	A rapid response (34.5) for CdO-ZnO nanorices based formaldehyde gas sensor was observed as compared to other gases such as ammonia (12.3), methanol (16.5), ethanol (20), carbon monoxide (16.3) and methane (12.4), which confirm the high-selectivity towards formaldehyde gas.	Formaldehyde	52-64	cell adhesion associated, oncogene regulated	Homo sapiens	28-31
34058181-7	2021	A rapid response (34.5) for CdO-ZnO nanorices based formaldehyde gas sensor was observed as compared to other gases such as ammonia (12.3), methanol (16.5), ethanol (20), carbon monoxide (16.3) and methane (12.4), which confirm the high-selectivity towards formaldehyde gas.	Formaldehyde	257-269	cell adhesion associated, oncogene regulated	Homo sapiens	28-31
33997872-0	2021	Formaldehyde regulates tetrahydrofolate stability and thymidylate synthase catalysis.	Formaldehyde	0-12	thymidylate synthetase	Homo sapiens	54-74
33727053-8	2021	Intrathecal P7C3 and NAMPT produced an antinociceptive effect in the formalin test.	Formaldehyde	69-77	nicotinamide phosphoribosyltransferase	Rattus norvegicus	21-26
33727056-7	2021	Our data showed that peripheral inflammation induced by formalin decreased the expression of glycine receptor alpha1 subunit on the plasma membrane of DRG neurons, which was attributed to the activation of protein kinase C signaling.	Formaldehyde	56-64	glycine receptor, alpha 1 subunit	Mus musculus	93-124
33727261-3	2021	EXPERIMENTAL DESIGN: Formalin-fixed paraffin embedded (FFPE) tissues were collected from UK/ANZ DCIS trial participants (n=755) and ER/PgR expression was evaluated by immunohistochemistry in 181 cases (with recurrence) matched to 362 controls by treatment-arm and age.	Formaldehyde	21-29	epiregulin	Homo sapiens	3-5
33993060-7	2021	In this study, we have identified 44 (26.19 %) NOTCH1 gene mutations from a whole-exome sequencing of 168 OSCC formalin-fixed, paraffin-embedded (FFPE) tissue specimen.	Formaldehyde	111-119	notch receptor 1	Homo sapiens	47-53
33976570-4	2021	Methods: The analgesic effect of ulinastatin on acute somatic and visceral pain was evaluated by using formalin and acetic acid-induced writhing test.	Formaldehyde	103-111	alpha-1-microglobulin/bikunin precursor	Rattus norvegicus	33-44
33976570-7	2021	pre-administration and post-administration of ulinastatin could reduce the total number of flinching and the licking duration following intraplantar formalin injection in a dose-related manner.	Formaldehyde	149-157	alpha-1-microglobulin/bikunin precursor	Rattus norvegicus	46-57
33976570-8	2021	However, the inhibitory effect of ulinastatin existed only in the second phase (Phase 2) of formalin-induced spontaneous pain response, with no effect in the first phase (Phase 1).	Formaldehyde	92-100	alpha-1-microglobulin/bikunin precursor	Rattus norvegicus	34-45
33976570-13	2021	We further demonstrated that ulinastatin significantly decreased the local inflammatory cell infiltration in injured paw and peritoneum tissue under formalin and acetic acid test separately.	Formaldehyde	149-157	alpha-1-microglobulin/bikunin precursor	Rattus norvegicus	29-40
33667423-5	2021	Formalin-fixed paraffin-embedded tissues derived from patients were used for immunohistochemical staining of L1CAM, BAP1, MTAP, and HEG1 in 51 uterine AT cases, 34 pleural or peritoneal MM cases, and for next-generation sequencing of the TRAF7 gene in 44 AT cases and 21 MM cases.	Formaldehyde	0-8	L1 cell adhesion molecule	Homo sapiens	109-114
33667423-5	2021	Formalin-fixed paraffin-embedded tissues derived from patients were used for immunohistochemical staining of L1CAM, BAP1, MTAP, and HEG1 in 51 uterine AT cases, 34 pleural or peritoneal MM cases, and for next-generation sequencing of the TRAF7 gene in 44 AT cases and 21 MM cases.	Formaldehyde	0-8	BRCA1 associated protein 1	Homo sapiens	116-120
33667423-5	2021	Formalin-fixed paraffin-embedded tissues derived from patients were used for immunohistochemical staining of L1CAM, BAP1, MTAP, and HEG1 in 51 uterine AT cases, 34 pleural or peritoneal MM cases, and for next-generation sequencing of the TRAF7 gene in 44 AT cases and 21 MM cases.	Formaldehyde	0-8	methylthioadenosine phosphorylase	Homo sapiens	122-126
33667423-5	2021	Formalin-fixed paraffin-embedded tissues derived from patients were used for immunohistochemical staining of L1CAM, BAP1, MTAP, and HEG1 in 51 uterine AT cases, 34 pleural or peritoneal MM cases, and for next-generation sequencing of the TRAF7 gene in 44 AT cases and 21 MM cases.	Formaldehyde	0-8	TNF receptor associated factor 7	Homo sapiens	238-243
33996912-4	2021	Here, we describe the use of mIF tyramide signal amplification for labeling up to eight markers on a single slide of formalin-fixed, paraffin-embedded tumor tissue to phenotype immune cells in tumor tissues.	Formaldehyde	117-125	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	29-32
33660008-4	2021	METHODS: Expression analysis of SPHK1 was performed on formalin-fixed paraffin-embedded tissue from 1005 ovarian cancer patients with different histological subtypes using immunohistochemistry.	Formaldehyde	55-63	sphingosine kinase 1	Homo sapiens	32-37
33893247-6	2021	The accuracy of ERBB2 copy number variations in tissue/formalin-fixed and paraffin-embedded samples was 95% with 86% sensitivity and 99% specificity.	Formaldehyde	55-63	erb-b2 receptor tyrosine kinase 2	Homo sapiens	16-21
33891627-6	2021	Formalin-fixed, paraffin-embedded tissue was used for p16 staining (a surrogate marker for HPV) and testing for HPV DNA presence and type by Multiplex HPV PCR-MassArray.	Formaldehyde	0-8	cyclin dependent kinase inhibitor 2A	Homo sapiens	54-57
33890816-5	2021	Here, we tested several commercially available serological reagents and identified a monoclonal antibody suitable for the immunohistochemical detection of PRAME in formalin-fixed paraffin-embedded specimens.	Formaldehyde	164-172	PRAME nuclear receptor transcriptional regulator	Homo sapiens	155-160
33876365-7	2021	The atmospheric lifetime of i-PME is found to be 2.8 h. Further, we have identified 2-hydroxy-2-methoxypropanol, methyl acetate, methy-1,2-hydroxyacetate and 1-hydroxypropane-2-one, 1,2-dihydroxypropan-2-yl format, 2-hydroxyacetic acid, acetic acid, and formaldehyde from the secondary oxidation of product radicals.	Formaldehyde	254-266	cystatin B	Homo sapiens	30-33
33895166-4	2021	METHODS: We used immunohistochemistry to visualise loss of the cancer driver KDM6A in formalin-fixed paraffin embedded (FFPE) normal human colonic epithelium.	Formaldehyde	86-94	lysine demethylase 6A	Homo sapiens	77-82
33512438-2	2021	This disorder is likely caused by the loss of a catabolic system directed toward endogenous formaldehyde, due to biallelic variants in ADH5 combined with a heterozygous ALDH2*2 dominant-negative allele (rs671), which is associated with alcohol-induced Asian flushing.	Formaldehyde	92-104	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	135-139
33512438-2	2021	This disorder is likely caused by the loss of a catabolic system directed toward endogenous formaldehyde, due to biallelic variants in ADH5 combined with a heterozygous ALDH2*2 dominant-negative allele (rs671), which is associated with alcohol-induced Asian flushing.	Formaldehyde	92-104	aldehyde dehydrogenase 2 family member	Homo sapiens	169-174
33512438-6	2021	We found that ADH5 is the primary defense against formaldehyde, and ALDH2 provides a backup.	Formaldehyde	50-62	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	14-18
33512438-7	2021	DNA repair capacity in the ADH5/ALDH2-deficient cell lines can be overwhelmed by exogenous low-dose formaldehyde as indicated by higher levels of DNA damage than FANCD2-deficient cells.	Formaldehyde	100-112	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	27-31
33512438-7	2021	DNA repair capacity in the ADH5/ALDH2-deficient cell lines can be overwhelmed by exogenous low-dose formaldehyde as indicated by higher levels of DNA damage than FANCD2-deficient cells.	Formaldehyde	100-112	aldehyde dehydrogenase 2 family member	Homo sapiens	32-37
33512438-7	2021	DNA repair capacity in the ADH5/ALDH2-deficient cell lines can be overwhelmed by exogenous low-dose formaldehyde as indicated by higher levels of DNA damage than FANCD2-deficient cells.	Formaldehyde	100-112	FA complementation group D2	Homo sapiens	162-168
33512438-10	2021	We propose that hematopoiesis or lymphocyte blastogenesis may entail formaldehyde generation that necessitates elimination by ADH5/ALDH2 enzymes.	Formaldehyde	69-81	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	126-130
33512438-10	2021	We propose that hematopoiesis or lymphocyte blastogenesis may entail formaldehyde generation that necessitates elimination by ADH5/ALDH2 enzymes.	Formaldehyde	69-81	aldehyde dehydrogenase 2 family member	Homo sapiens	131-136
33839437-4	2021	The cD1 status (gene amplified/nonamplified) was determined on formalin-fixed paraffin-embedded tumor tissue sections by chromogenic in situ hybridization.	Formaldehyde	63-71	cyclin D1	Homo sapiens	4-7
33387762-6	2021	Carbonyls played a vital role in both the primary formation and recycling of the ROx; more than 80% of the primary source of HO2 and RO2 came from photolysis of formaldehyde and other oxygenated VOCs.	Formaldehyde	161-173	MAX network transcriptional repressor	Homo sapiens	81-84
33387762-6	2021	Carbonyls played a vital role in both the primary formation and recycling of the ROx; more than 80% of the primary source of HO2 and RO2 came from photolysis of formaldehyde and other oxygenated VOCs.	Formaldehyde	161-173	heme oxygenase 2	Homo sapiens	125-128
33840146-9	2021	Next-generation sequencing studies (sarcoma gene fusion NGS panel with subsequent Sanger confirmation) performed on formalin-fixed paraffin-embedded tissue detected a fusion product between MEAF6 exon 4 (NM_001270875) and SUZ12 exon 2 (NM_001321207.1).	Formaldehyde	116-124	MYST/Esa1 associated factor 6	Homo sapiens	190-195
33840146-9	2021	Next-generation sequencing studies (sarcoma gene fusion NGS panel with subsequent Sanger confirmation) performed on formalin-fixed paraffin-embedded tissue detected a fusion product between MEAF6 exon 4 (NM_001270875) and SUZ12 exon 2 (NM_001321207.1).	Formaldehyde	116-124	SUZ12 polycomb repressive complex 2 subunit	Homo sapiens	222-227
33836808-7	2021	The results revealed that every unit increase in BBzP concentration in the settled dust was associated with a 1.75% decrease in the methylation level on upstream 775 bp from the transcription start site (TSS) of TSLP (beta =  - 1.75, p = 0.015) after adjustment for child"s sex, age, BMI, parents" smoking status, allergic history, and education levels, PM2.5, formaldehyde, temperature; and relative humidity.	Formaldehyde	361-373	thymic stromal lymphopoietin	Homo sapiens	212-216
33897761-3	2021	In particular, certain types of ALKBH enzymes are dioxygenases that directly reverse DNA methylation damage via transfer of a methyl group from the DNA adduct onto alpha-ketoglutarate and release of metabolic products including succinate and formaldehyde.	Formaldehyde	242-254	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	32-37
33086223-7	2021	Immunohistochemical staining for NPY1R was done on paraffin-embedded formalin-fixed tissue sections.	Formaldehyde	69-77	neuropeptide Y receptor Y1	Homo sapiens	33-38
33321188-10	2021	Moreover, lipids analysis revealed IAAs might down-regulate inflammatory mediators from COX, LOX, DHA and LA pathways in formalin models, thus showing anti-inflammatory effect.	Formaldehyde	121-129	lysyl oxidase	Mus musculus	93-96
32580587-7	2021	The betatrophin and total antioxidant status levels decreased in kidney, liver and plasma following exposure to formaldehyde, while total oxidant status and terminal deoxynucleotidyl transferase dUTP nick end labeling positivity increased.	Formaldehyde	112-124	angiopoietin-like 8	Rattus norvegicus	4-15
33108706-0	2021	Formalin fixation for optimal concordance of programmed death-ligand 1 immunostaining between cytologic and histologic specimens from patients with non-small cell lung cancer.	Formaldehyde	0-8	CD274 molecule	Homo sapiens	45-70
33549904-6	2021	Trophoblast miR-126-3p expression was assessed by in situ hybridization of formalin-fixed tissue sections and by RT-PCR in cultured syncytiotrophoblasts.	Formaldehyde	75-83	microRNA 1263	Homo sapiens	12-22
33635430-4	2021	METHODS: In this retrospective study, Sanger sequencing was performed to detect TERT-p mutations in formalin-fixed paraffin-embedded tissue samples from 37 patients with penile SCC, 16 patients with cutaneous SCC, and 4 patients with non-neoplastic penile/skin tissue.	Formaldehyde	100-108	telomerase reverse transcriptase	Homo sapiens	80-84
33710781-4	2021	DAAO inhibitors benzoic acid, CBIO, and SUN significantly inhibited formalin-induced tonic pain in Balb/c and Swiss mice, but had no antinociceptive effect in C57 mice.	Formaldehyde	68-76	D-amino acid oxidase	Mus musculus	0-4
33418141-8	2021	In mammals, the toxicity of formaldehyde is limited by a metabolic route centred on the enzyme alcohol dehydrogenase 5 (ADH5/GSNOR), which oxidizes formaldehyde conjugated to GSH, lastly generating formate.	Formaldehyde	28-40	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	120-124
33691963-0	2021	Co-overexpression of AtSHMT1 and AtFDH induces sugar synthesis and enhances the role of original pathways during formaldehyde metabolism in tobacco.	Formaldehyde	113-125	serine transhydroxymethyltransferase 1	Arabidopsis thaliana	21-28
33691963-0	2021	Co-overexpression of AtSHMT1 and AtFDH induces sugar synthesis and enhances the role of original pathways during formaldehyde metabolism in tobacco.	Formaldehyde	113-125	formate dehydrogenase	Arabidopsis thaliana	33-38
33418141-8	2021	In mammals, the toxicity of formaldehyde is limited by a metabolic route centred on the enzyme alcohol dehydrogenase 5 (ADH5/GSNOR), which oxidizes formaldehyde conjugated to GSH, lastly generating formate.	Formaldehyde	28-40	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	125-130
33418141-8	2021	In mammals, the toxicity of formaldehyde is limited by a metabolic route centred on the enzyme alcohol dehydrogenase 5 (ADH5/GSNOR), which oxidizes formaldehyde conjugated to GSH, lastly generating formate.	Formaldehyde	148-160	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	120-124
33418141-8	2021	In mammals, the toxicity of formaldehyde is limited by a metabolic route centred on the enzyme alcohol dehydrogenase 5 (ADH5/GSNOR), which oxidizes formaldehyde conjugated to GSH, lastly generating formate.	Formaldehyde	148-160	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	125-130
33046151-8	2021	In conclusion, several tested markers were able to withstand formaldehyde fixation of ram semen samples as follows: annexin V and FLICA for apoptosis; PNA for acrosomal status; MitoTracker Red CMXRos for mitochondrial activity; and CellROX Green for oxidative status in combination with a suitable live/dead fixable viability dye.	Formaldehyde	61-73	annexin A5	Homo sapiens	116-125
33661805-0	2021	Deletion of MyD88 adaptor in nociceptor alleviates low-dose formalin-induced acute pain and persistent pain in mice.	Formaldehyde	60-68	myeloid differentiation primary response gene 88	Mus musculus	12-17
33782193-1	2021	AIMS: This study aimed to validate the application of combined multiplex immunofluorescence (mIF) and digital image analysis (DIA) in formalin-fixed and paraffin-embedded tissues for the quantitative assessment of programmed death-ligand 1(PD-L1) and immune cells (ICs) in non-small cell lung cancer (NSCLC).	Formaldehyde	134-142	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	93-96
33661805-3	2021	However, whether MyD88 in nociceptive neurons contributes to persistent pain induced by intraplantar injection of formalin remains elusive.	Formaldehyde	114-122	myeloid differentiation primary response gene 88	Mus musculus	17-22
33661805-4	2021	Here, using conditional knockout (CKO) mice, we found that selective deletion of Myd88 in Nav1.8-expressing primary nociceptive neurons led to reduced pain response in the recovery phase of 1% formalin-induced mechanical pain and impaired the persistent thermal pain.	Formaldehyde	193-201	myeloid differentiation primary response gene 88	Mus musculus	81-86
33661805-4	2021	Here, using conditional knockout (CKO) mice, we found that selective deletion of Myd88 in Nav1.8-expressing primary nociceptive neurons led to reduced pain response in the recovery phase of 1% formalin-induced mechanical pain and impaired the persistent thermal pain.	Formaldehyde	193-201	sodium channel, voltage-gated, type X, alpha	Mus musculus	90-96
33661805-6	2021	Finally, nociceptor MyD88 deletion resulted in less neuronal c-Fos activation in spinal dorsal horns following 1% formalin stimulation.	Formaldehyde	114-122	myeloid differentiation primary response gene 88	Mus musculus	20-25
33661805-6	2021	Finally, nociceptor MyD88 deletion resulted in less neuronal c-Fos activation in spinal dorsal horns following 1% formalin stimulation.	Formaldehyde	114-122	FBJ osteosarcoma oncogene	Mus musculus	61-66
33661805-7	2021	These data suggest that MyD88 in nociceptive neurons is not only involved in persistent mechanical pain but also promotes the transition from acute inflammatory pain to persistent thermal hyperalgesia induced by low-dose formalin stimulation.	Formaldehyde	221-229	myeloid differentiation primary response gene 88	Mus musculus	24-29
33208670-5	2021	Albumin mRNA detection was performed using RNAscope run on formalin-fixed, paraffin-embedded tissue sections.	Formaldehyde	59-67	albumin	Homo sapiens	0-7
33757529-14	2021	Finally, pharmacological inhibition of CCR2 reversed the pronociceptive action of CCL2 in rats receiving formalin injection and significantly reduced the neurogenic inflammation as well as the stimuli-evoked and movement-evoked nociceptive behaviors in CFA-treated rats.	Formaldehyde	105-113	C-C motif chemokine receptor 2	Rattus norvegicus	39-43
33757529-14	2021	Finally, pharmacological inhibition of CCR2 reversed the pronociceptive action of CCL2 in rats receiving formalin injection and significantly reduced the neurogenic inflammation as well as the stimuli-evoked and movement-evoked nociceptive behaviors in CFA-treated rats.	Formaldehyde	105-113	C-C motif chemokine ligand 2	Rattus norvegicus	82-86
33710124-3	2021	Preliminary studies in our laboratory found low immunostaining for the NeuN antibody on formalin fixed and paraffin embedded (FFPE) human brain tissue.	Formaldehyde	88-96	RNA binding fox-1 homolog 3	Homo sapiens	71-75
33675181-6	2021	Expression of Notch1 receptor and NICD1 was evaluated by immunohistochemistry on formalin fixed paraffin embedded tissues.	Formaldehyde	81-89	notch receptor 1	Homo sapiens	14-20
33759071-4	2022	This study contained two cohorts: in cohort A, AQP9 protein expression (from formalin fixed paraffin embedded tumor and paired adjacent tissue specimens) in 198 patients was detected by immunohistochemistry (IHC).	Formaldehyde	77-85	aquaporin 9	Homo sapiens	47-51
33734108-3	2021	In this study, formalin fixed paraffin embedded clinical specimens (16 liposarcomas and 19 benign lipomatous tumors) were used to detect MDM2 amplification and other chromosomal alterations in WDLS/ALT and DDLS by single nucleotide polymorphism-based chromosome microarray (CMA).	Formaldehyde	15-23	MDM2 proto-oncogene	Homo sapiens	137-141
33734108-12	2021	In conclusion, this study demonstrated that CMA on routine formalin fixed paraffin embedded tissue is a sensitive and specific clinical test for detection of MDM2 gene amplification.	Formaldehyde	59-67	MDM2 proto-oncogene	Homo sapiens	158-162
33751222-5	2021	Here we report a case of systemic apolipoprotein A-IV-associated amyloidosis that was confirmed by proteome analysis using formalin-fixed paraffin-embedded tissue and an immunohistochemical technique.	Formaldehyde	123-131	apolipoprotein A4	Homo sapiens	34-53
33257173-5	2021	5-Amino-2-methoxyphenol (2) and 5-aminoindazole (3) displayed efficient target protein interactions with a dose-dependent antinociceptive effect in the mice formalin test, which in the second phase was dependent on FAAH and TRPV1.	Formaldehyde	157-165	fatty acid amide hydrolase	Mus musculus	215-219
33257173-5	2021	5-Amino-2-methoxyphenol (2) and 5-aminoindazole (3) displayed efficient target protein interactions with a dose-dependent antinociceptive effect in the mice formalin test, which in the second phase was dependent on FAAH and TRPV1.	Formaldehyde	157-165	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	224-229
33226123-3	2021	We explored the incidence of isocitrate dehydrogenase 1 gene variants by hotspot sequencing in 80 formalin-fixed paraffin-embedded tissues of different types of glioma biopsy samples.	Formaldehyde	98-106	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	29-55
33608311-5	2021	MATERIALS AND METHODS: AR and PIM1 transcripts were quantified by quantitative reverse transcription polymerase chain reaction in formalin-fixed paraffin-embedded tumor from 141 patients with TNBC.	Formaldehyde	130-138	androgen receptor	Homo sapiens	23-25
33385586-4	2021	We report development of a qRT-PCR-based Lymphoma cell-of-origin (LCOO) assay to determine ABC, GCB, and Unclassifiable (UC) subtypes in formalin-fixed, paraffin embedded tissue (FFPET) DLBCL samples.	Formaldehyde	137-145	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	91-94
33097464-11	2021	CONCLUSIONS: In our laboratory, formalin fixation of CB material improved the accuracy of p16 interpretation.	Formaldehyde	32-40	cyclin dependent kinase inhibitor 2A	Homo sapiens	90-93
33097464-13	2021	Therefore, we advocate formalin fixation for head and neck cytology specimens that may require p16 testing.	Formaldehyde	23-31	cyclin dependent kinase inhibitor 2A	Homo sapiens	95-98
33631924-6	2021	Proteins of interest, including PRDX2, PRDX6, and Gelsolin, were differentially expressed in chemo-sensitive tumors versus chemo-resistant tissues and these observations were validated by immunohistochemistry in 92 formalin-fixed and paraffin-embedded (FFPE) specimens.	Formaldehyde	215-223	peroxiredoxin 2	Homo sapiens	32-37
33631924-6	2021	Proteins of interest, including PRDX2, PRDX6, and Gelsolin, were differentially expressed in chemo-sensitive tumors versus chemo-resistant tissues and these observations were validated by immunohistochemistry in 92 formalin-fixed and paraffin-embedded (FFPE) specimens.	Formaldehyde	215-223	peroxiredoxin 6	Homo sapiens	39-44
33631924-6	2021	Proteins of interest, including PRDX2, PRDX6, and Gelsolin, were differentially expressed in chemo-sensitive tumors versus chemo-resistant tissues and these observations were validated by immunohistochemistry in 92 formalin-fixed and paraffin-embedded (FFPE) specimens.	Formaldehyde	215-223	gelsolin	Homo sapiens	50-58
33681255-9	2021	Further, we found that 0.3% formalin-induced scratching was histamine-independent and significantly attenuated by transient receptor potential ion channel A1 (TRPA1) inhibitor (HC030031) or in TRPA1 knockout (KO) mice, but not affected by transient receptor potential ion channel V1 (TRPV1) inhibitor (capsazepine) or in TRPV1 KO mice.	Formaldehyde	28-36	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	114-157
33597223-4	2022	The automated Idylla epidermal growth factor receptor (EGFR) mutation test has been developed to rapidly process formalin-fixed paraffin-embedded (FFPE) pathologic material, without previous DNA extraction.	Formaldehyde	113-121	epidermal growth factor receptor	Homo sapiens	21-53
33597223-4	2022	The automated Idylla epidermal growth factor receptor (EGFR) mutation test has been developed to rapidly process formalin-fixed paraffin-embedded (FFPE) pathologic material, without previous DNA extraction.	Formaldehyde	113-121	epidermal growth factor receptor	Homo sapiens	55-59
33681255-0	2021	Formalin Itch Test: Low-Dose Formalin Induces Histamine-Independent, TRPA1-Mediated Itch in Mice.	Formaldehyde	0-8	itchy, E3 ubiquitin protein ligase	Mus musculus	9-13
33681255-9	2021	Further, we found that 0.3% formalin-induced scratching was histamine-independent and significantly attenuated by transient receptor potential ion channel A1 (TRPA1) inhibitor (HC030031) or in TRPA1 knockout (KO) mice, but not affected by transient receptor potential ion channel V1 (TRPV1) inhibitor (capsazepine) or in TRPV1 KO mice.	Formaldehyde	28-36	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	159-164
33681255-0	2021	Formalin Itch Test: Low-Dose Formalin Induces Histamine-Independent, TRPA1-Mediated Itch in Mice.	Formaldehyde	0-8	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	69-74
33681255-9	2021	Further, we found that 0.3% formalin-induced scratching was histamine-independent and significantly attenuated by transient receptor potential ion channel A1 (TRPA1) inhibitor (HC030031) or in TRPA1 knockout (KO) mice, but not affected by transient receptor potential ion channel V1 (TRPV1) inhibitor (capsazepine) or in TRPV1 KO mice.	Formaldehyde	28-36	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	193-198
33681255-0	2021	Formalin Itch Test: Low-Dose Formalin Induces Histamine-Independent, TRPA1-Mediated Itch in Mice.	Formaldehyde	0-8	itchy, E3 ubiquitin protein ligase	Mus musculus	84-88
33681255-0	2021	Formalin Itch Test: Low-Dose Formalin Induces Histamine-Independent, TRPA1-Mediated Itch in Mice.	Formaldehyde	29-37	itchy, E3 ubiquitin protein ligase	Mus musculus	9-13
33681255-9	2021	Further, we found that 0.3% formalin-induced scratching was histamine-independent and significantly attenuated by transient receptor potential ion channel A1 (TRPA1) inhibitor (HC030031) or in TRPA1 knockout (KO) mice, but not affected by transient receptor potential ion channel V1 (TRPV1) inhibitor (capsazepine) or in TRPV1 KO mice.	Formaldehyde	28-36	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	284-289
33681255-0	2021	Formalin Itch Test: Low-Dose Formalin Induces Histamine-Independent, TRPA1-Mediated Itch in Mice.	Formaldehyde	29-37	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	69-74
33681255-9	2021	Further, we found that 0.3% formalin-induced scratching was histamine-independent and significantly attenuated by transient receptor potential ion channel A1 (TRPA1) inhibitor (HC030031) or in TRPA1 knockout (KO) mice, but not affected by transient receptor potential ion channel V1 (TRPV1) inhibitor (capsazepine) or in TRPV1 KO mice.	Formaldehyde	28-36	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	321-326
33681255-0	2021	Formalin Itch Test: Low-Dose Formalin Induces Histamine-Independent, TRPA1-Mediated Itch in Mice.	Formaldehyde	29-37	itchy, E3 ubiquitin protein ligase	Mus musculus	84-88
33681255-10	2021	Additionally, 0.3% formalin-induced up-regulation of phosphorylation of extracellular regulated protein kinases (p-ERK) in the dorsal root ganglion (DRG) and scratching were suppressed by intrathecal injection of MEK inhibitor U0126 in mice.	Formaldehyde	19-27	mitogen-activated protein kinase 1	Mus musculus	115-118
33681255-10	2021	Additionally, 0.3% formalin-induced up-regulation of phosphorylation of extracellular regulated protein kinases (p-ERK) in the dorsal root ganglion (DRG) and scratching were suppressed by intrathecal injection of MEK inhibitor U0126 in mice.	Formaldehyde	19-27	midkine	Mus musculus	213-216
33681255-11	2021	Incubation of 0.03% formalin induced the accumulation of intracellular reactive oxygen species (ROS) in the cultured DRG-derived cell line ND7-23, and formalin-induced itch was suppressed by antioxidants in mice.	Formaldehyde	20-28	itchy, E3 ubiquitin protein ligase	Mus musculus	168-172
33681255-11	2021	Incubation of 0.03% formalin induced the accumulation of intracellular reactive oxygen species (ROS) in the cultured DRG-derived cell line ND7-23, and formalin-induced itch was suppressed by antioxidants in mice.	Formaldehyde	151-159	itchy, E3 ubiquitin protein ligase	Mus musculus	168-172
33681255-13	2021	Thus, these results indicate that low-dose formalin induced non-histaminergic itch by activation of TRPA1 in mice, which may be employed as a useful acute itch model for screening potential anti-itch drugs.	Formaldehyde	43-51	itchy, E3 ubiquitin protein ligase	Mus musculus	78-82
33681255-13	2021	Thus, these results indicate that low-dose formalin induced non-histaminergic itch by activation of TRPA1 in mice, which may be employed as a useful acute itch model for screening potential anti-itch drugs.	Formaldehyde	43-51	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	100-105
33681255-13	2021	Thus, these results indicate that low-dose formalin induced non-histaminergic itch by activation of TRPA1 in mice, which may be employed as a useful acute itch model for screening potential anti-itch drugs.	Formaldehyde	43-51	itchy, E3 ubiquitin protein ligase	Mus musculus	155-159
33681255-13	2021	Thus, these results indicate that low-dose formalin induced non-histaminergic itch by activation of TRPA1 in mice, which may be employed as a useful acute itch model for screening potential anti-itch drugs.	Formaldehyde	43-51	itchy, E3 ubiquitin protein ligase	Mus musculus	155-159
33475642-2	2021	Tetraethyl orthosilicate (TEOS) and resorcinol/formaldehyde (RF) assemble upon dictation by Ag+ and pyridyl-functionalized surfactants, producing porous carbon tubes (RF1) with a high surface area of 696 m2 g-1 and accessible mesopores ~15 nm in size.	Formaldehyde	47-59	mitochondrial translation release factor 1	Homo sapiens	167-170
33567341-8	2021	USP11 depletion impairs SPRTN deubiquitination and promotes SPRTN auto-proteolysis in response to formaldehyde-induced DPCs.	Formaldehyde	98-110	ubiquitin specific peptidase 11	Homo sapiens	0-5
33567341-8	2021	USP11 depletion impairs SPRTN deubiquitination and promotes SPRTN auto-proteolysis in response to formaldehyde-induced DPCs.	Formaldehyde	98-110	SprT-like N-terminal domain	Homo sapiens	60-65
33547330-5	2021	The SNP rs2234693 in the ESR1 gene was genotyped on DNA from formalin-fixed paraffin embedded (FFPE) tumor tissue using Taqman assays and related to the primary endpoint disease-free survival (DFS) and secondary endpoint overall survival (OS).	Formaldehyde	61-69	estrogen receptor 1	Homo sapiens	25-29
33690411-1	2021	Nanosecond electronic-resonance-enhanced coherent anti-Stokes Raman scattering (ERE-CARS) is evaluated for the measurement of formaldehyde (CH2O) concentrations in reacting and nonreacting conditions.	Formaldehyde	126-138	cysteinyl-tRNA synthetase 1	Homo sapiens	84-88
32590454-0	2021	Aberrant Cytoplasmic Terminal Deoxynucleotidyl Transferase (TdT) Immunostaining on Previously Frozen, Formalin-fixed Paraffin-embedded Tissue: Cryotomy-induced Antigen Diffusion (CIAD).	Formaldehyde	102-110	DNA nucleotidylexotransferase	Homo sapiens	21-58
32590454-0	2021	Aberrant Cytoplasmic Terminal Deoxynucleotidyl Transferase (TdT) Immunostaining on Previously Frozen, Formalin-fixed Paraffin-embedded Tissue: Cryotomy-induced Antigen Diffusion (CIAD).	Formaldehyde	102-110	DNA nucleotidylexotransferase	Homo sapiens	60-63
32590454-1	2021	Terminal deoxynucleotidyl transferase (TdT) has been localized in both the nuclear and cytoplasmic compartments of lymphoblastic lymphomas when such tumors have been frozen for cryotomy and subsequently, formalin fixed and processed to paraffin.	Formaldehyde	204-212	DNA nucleotidylexotransferase	Homo sapiens	0-37
32590454-1	2021	Terminal deoxynucleotidyl transferase (TdT) has been localized in both the nuclear and cytoplasmic compartments of lymphoblastic lymphomas when such tumors have been frozen for cryotomy and subsequently, formalin fixed and processed to paraffin.	Formaldehyde	204-212	DNA nucleotidylexotransferase	Homo sapiens	39-42
33690411-1	2021	Nanosecond electronic-resonance-enhanced coherent anti-Stokes Raman scattering (ERE-CARS) is evaluated for the measurement of formaldehyde (CH2O) concentrations in reacting and nonreacting conditions.	Formaldehyde	140-144	cysteinyl-tRNA synthetase 1	Homo sapiens	84-88
32671697-0	2021	Ifenprodil Reduced Expression of Activated Microglia, BDNF and DREAM Proteins in the Spinal Cord Following Formalin Injection During the Early Stage of Painful Diabetic Neuropathy in Rats.	Formaldehyde	107-115	potassium voltage-gated channel interacting protein 3	Rattus norvegicus	63-68
33341450-3	2021	PATIENT AND METHODS: CDX2 protein expression was evaluated in 386 stage II and III primary colon cancers by immunohistochemical staining of tissue microarrays and by liquid chromatography with tandem mass spectrometry (LC-MS/MS) analysis using formalin-fixed paraffin-embedded tissue sections of a matched subset of 23 recurrent and 23 non-recurrent colon cancers.	Formaldehyde	244-252	caudal type homeobox 2	Homo sapiens	21-25
33020971-3	2021	We also developed an immunohistochemical stain for EFEMP1 applicable to formalin-fixed tissue sections and performed electron microscopy in one case.	Formaldehyde	72-80	EGF containing fibulin extracellular matrix protein 1	Homo sapiens	51-57
32671697-3	2021	This study aims to determine the effect of ifenprodil, a potent noncompetitive NMDAR-2B antagonist, on activated microglia, brain-derived neurotrophic factors (BDNF) and downstream regulatory element antagonist modulator (DREAM) protein expression in the spinal cord of streptozotocin-induced painful diabetic neuropathy (PDN) rats following formalin injection.	Formaldehyde	342-350	potassium voltage-gated channel interacting protein 3	Rattus norvegicus	222-227
32671697-10	2021	The results demonstrated a significant increase in formalin-induced flinching and licking behavior with an increased spinal expression of activated microglia, BDNF and DREAM proteins.	Formaldehyde	51-59	potassium voltage-gated channel interacting protein 3	Rattus norvegicus	168-173
32488689-4	2021	Formalin fixation of 24 h led to the most optimal results of DLL3 IHC.	Formaldehyde	0-8	LOC105375808	Homo sapiens	61-65
33514586-2	2022	The Biocartis Idylla platform and single-use EGFR mutation test cartridge is CE-IVD for use with formalin-fixed paraffin embedded (FFPE) tumour material, but can also function off-scope using extracted DNA as input material.	Formaldehyde	97-105	epidermal growth factor receptor	Homo sapiens	45-49
33572647-6	2021	The expression of PARP1 was also assessed by immunohistochemistry in formalin-fixed paraffin-embedded tissues of 128 primary cutaneous melanoma patients and correlated with follow-up and clinicopathologic features.	Formaldehyde	69-77	poly(ADP-ribose) polymerase 1	Homo sapiens	18-23
33494253-4	2021	Inflammatory pain was modeled in CD-1 mice by the intraplantar injection of carrageenan, interleukin IL-1beta and formalin.	Formaldehyde	114-122	CD1 antigen complex	Mus musculus	33-37
33584270-8	2020	SMase (50 mU) significantly reduced TRPA1 activation (formalin)-induced acute nocifensive behaviors by 64% in the second, neurogenic inflammatory phase.	Formaldehyde	54-62	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	36-41
33455577-5	2021	Immunohistochemical expression of AQP4 was analyzed using formalin-fixed paraffin-embedded brain tissue sections.	Formaldehyde	58-66	aquaporin 4	Canis lupus familiaris	34-38
33280268-1	2021	BACKGROUND: Human epidermal growth factor receptor 2-in situ hybridization (HER2-ISH) is widely approved for diagnostic, prognostic biomarker testing of formalin-fixed paraffin-embedded tissue blocks.	Formaldehyde	153-161	erb-b2 receptor tyrosine kinase 2	Homo sapiens	18-52
33840672-4	2021	We also determined the effect of formalin and VWR on the protein expression levels of brain-derived neurotrophic factor (BDNF), its receptor TrkB, and K+-Cl- cotransporter 2 (KCC2), which play a key role in inducing allodynia and hyperalgesia.	Formaldehyde	33-41	brain-derived neurotrophic factor	Rattus norvegicus	86-119
33840672-4	2021	We also determined the effect of formalin and VWR on the protein expression levels of brain-derived neurotrophic factor (BDNF), its receptor TrkB, and K+-Cl- cotransporter 2 (KCC2), which play a key role in inducing allodynia and hyperalgesia.	Formaldehyde	33-41	solute carrier family 12 member 5	Rattus norvegicus	151-173
33136093-4	2021	METHODS: An immunohistochemical study using an HOXA5 antibody was performed on 85 formalin fixed paraffin embedded specimens from patients with CRC.	Formaldehyde	82-90	homeobox A5	Homo sapiens	47-52
33445653-0	2021	Seeding Propensity and Characteristics of Pathogenic alphaSyn Assemblies in Formalin-Fixed Human Tissue from the Enteric Nervous System, Olfactory Bulb, and Brainstem in Cases Staged for Parkinson"s Disease.	Formaldehyde	76-84	synuclein alpha	Homo sapiens	53-61
33445653-2	2021	Specifically, we assessed the seeding propensity of pathogenic alphaSyn in formalin-fixed tissue from the gastric cardia and five brain regions of 29 individuals (12 Parkinson"s disease, 8 incidental Lewy body disease, 9 controls) using a protein misfolding cyclic amplification assay.	Formaldehyde	75-83	synuclein alpha	Homo sapiens	63-71
33445529-3	2021	In this paper, we show the positive effect of a set of imidazole-based ionic liquids ([bmim]BF4 and [hmim]PF6) in the enantioselective addition of formaldehyde tert-butylhydrazone to prochiral alpha-keto esters catalyzed by a sugar-based chiral thiourea.	Formaldehyde	147-159	sperm associated antigen 17	Homo sapiens	106-109
33068634-7	2021	Finally, intrathecal KN93 reduced formalin-induced nociceptive behaviors in GluN2BKI mice.	Formaldehyde	34-42	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	76-84
33280268-1	2021	BACKGROUND: Human epidermal growth factor receptor 2-in situ hybridization (HER2-ISH) is widely approved for diagnostic, prognostic biomarker testing of formalin-fixed paraffin-embedded tissue blocks.	Formaldehyde	153-161	erb-b2 receptor tyrosine kinase 2	Homo sapiens	76-80
33631963-6	2021	Next-generation sequencing (NGS) was performed on formalin-fixed paraffin-embedded tumor tissue, revealing one mutation in exon 5, TP53: p.A159 V, which may be associated with chemo-resistance.	Formaldehyde	50-58	tumor protein p53	Homo sapiens	131-135
33433416-2	2021	Aim: To validate the diagnosis made by morphology and immunohistochemistry (IHC) by fluorescence in-situ hybridization (FISH) for EWSR1 rearrangement on formalin fixed paraffin embedded (FFPE) tissues.	Formaldehyde	153-161	EWS RNA binding protein 1	Homo sapiens	130-135
34019287-5	2021	We will also discuss the challenges of detecting phosphorylated c-Myc in formalin-fixed paraffin-embedded tissues by immunofluorescence and describe a protocol using a new rat monoclonal antibody we have generated suitable for this purpose.	Formaldehyde	73-81	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	64-69
33322957-0	2021	Long-term exposure to formaldehyde induced down-regulation of SPO11 in rats.	Formaldehyde	22-34	SPO11, initiator of meiotic double stranded breaks	Rattus norvegicus	62-67
33322957-3	2021	Materials and methods: The present study aimed to explore the role of SPO11 in male reproductive injury induced by long-term formaldehyde exposure, so as to further understand the molecular mechanism of formaldehyde-induced male reproductive toxicity.	Formaldehyde	125-137	SPO11, initiator of meiotic double stranded breaks	Rattus norvegicus	70-75
33322957-3	2021	Materials and methods: The present study aimed to explore the role of SPO11 in male reproductive injury induced by long-term formaldehyde exposure, so as to further understand the molecular mechanism of formaldehyde-induced male reproductive toxicity.	Formaldehyde	203-215	SPO11, initiator of meiotic double stranded breaks	Rattus norvegicus	70-75
33322957-6	2021	The results indicated that the expression of SPO11 was inhibited by formaldehyde exposure in a dose-dependent manner.	Formaldehyde	68-80	SPO11, initiator of meiotic double stranded breaks	Rattus norvegicus	45-50
33322957-8	2021	Combined with the morphometric results, we found that the downregulated expression levels of SPO11 were consistent with the changes of testicular seminiferous tubule diameter and seminiferous epithelium height in testicular tissue, suggesting that SPO11 might be one of the main targets of formaldehyde reproductive toxicity.	Formaldehyde	290-302	SPO11, initiator of meiotic double stranded breaks	Rattus norvegicus	93-98
33322957-8	2021	Combined with the morphometric results, we found that the downregulated expression levels of SPO11 were consistent with the changes of testicular seminiferous tubule diameter and seminiferous epithelium height in testicular tissue, suggesting that SPO11 might be one of the main targets of formaldehyde reproductive toxicity.	Formaldehyde	290-302	SPO11, initiator of meiotic double stranded breaks	Rattus norvegicus	248-253
33322957-9	2021	Conclusions: In conclusion, our findings indicated that SPO11 might be related to male reproductive injuries induced by long-term formaldehyde exposure.	Formaldehyde	130-142	SPO11, initiator of meiotic double stranded breaks	Rattus norvegicus	56-61
32732636-3	2021	Sucrase isomaltase (SI) gene variants were detected by next-generation sequencing (NGS) of DNA from formalin-fixed-paraffin-embedded (FFPE) tissues of these patients.	Formaldehyde	100-108	sucrase-isomaltase	Homo sapiens	0-18
32732636-3	2021	Sucrase isomaltase (SI) gene variants were detected by next-generation sequencing (NGS) of DNA from formalin-fixed-paraffin-embedded (FFPE) tissues of these patients.	Formaldehyde	100-108	sucrase-isomaltase	Homo sapiens	20-22
33130391-0	2021	Effect of formaldehyde properties on SnO2 clusters gas sensitivity: A DFT study.	Formaldehyde	10-22	strawberry notch homolog 1	Homo sapiens	37-40
33683681-6	2021	Here we describe an automated IHC protocol used in our laboratory for the detection of TTF-1 in formalin-fixed, paraffin-embedded (FFPE) tissue sections from lung tumors.	Formaldehyde	96-104	transcription termination factor 1	Homo sapiens	87-92
34019299-0	2021	Chromogenic In Situ Hybridization (CISH) as a Method for Detection of C-Myc Amplification in Formalin-Fixed Paraffin-Embedded Tumor Tissue: An Update.	Formaldehyde	93-101	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	70-75
33683683-0	2021	Automated Immunohistochemistry Assay for the Detection of Napsin-A in Formalin-Fixed Paraffin-Embedded Tissues from Lung Tumors.	Formaldehyde	70-78	napsin A aspartic peptidase	Homo sapiens	58-66
33683684-6	2021	Here we describe an automated immunohistochemistry staining procedure that can be applied for the validation of multiple anti-PD-L1 antibody clones when used for the staining of formalin-fixed, paraffin-embedded lung cancer tissue sections.	Formaldehyde	178-186	CD274 molecule	Homo sapiens	126-131
33683685-5	2021	PD-L1 is a major immune checkpoint protein that mediates antitumor immune suppression and response, which is routinely detected using IHC in formalin-fixed and paraffin-embedded tissues as part of cancer clinical diagnostic workflows.	Formaldehyde	141-149	CD274 molecule	Homo sapiens	0-5
33355142-0	2020	Digenic mutations in ALDH2 and ADH5 impair formaldehyde clearance and cause a multisystem disorder, AMeD syndrome.	Formaldehyde	43-55	aldehyde dehydrogenase 2, mitochondrial	Mus musculus	21-26
33704740-3	2021	Multiplex immunohistochemistry (mIHC) is a new technology which addresses this issue and enables simultaneous detection of melanoma and multiple immune subsets in formalin fixed paraffin embedded tissue.	Formaldehyde	163-171	myosin IA	Mus musculus	32-36
33573476-0	2021	Neuropeptide W, an endogenous NPBW1 and NPBW2 ligand, produced an analgesic effect via activation of the descending pain modulatory system during a rat formalin test.	Formaldehyde	152-160	neuropeptide W	Rattus norvegicus	0-14
32814203-5	2020	The glyoxal:formaldehyde ratio (Rgf), reported for the first time in Australia, was consistently high compared to values elsewhere in the world with a mean of 0.105 +- 0.0503 and tended to increase with increasing anthropogenic influence.	Formaldehyde	12-24	ral guanine nucleotide dissociation stimulator	Homo sapiens	32-35
33355142-0	2020	Digenic mutations in ALDH2 and ADH5 impair formaldehyde clearance and cause a multisystem disorder, AMeD syndrome.	Formaldehyde	43-55	alcohol dehydrogenase 5 (class III), chi polypeptide	Mus musculus	31-35
33147438-4	2020	We show that formaldehyde is a common substrate of ALDH2 and ADH5 and establish methods to quantify elevated blood formaldehyde and formaldehyde-DNA adducts in tissues.	Formaldehyde	13-25	aldehyde dehydrogenase 2, mitochondrial	Mus musculus	51-56
33147438-4	2020	We show that formaldehyde is a common substrate of ALDH2 and ADH5 and establish methods to quantify elevated blood formaldehyde and formaldehyde-DNA adducts in tissues.	Formaldehyde	13-25	alcohol dehydrogenase 5 (class III), chi polypeptide	Mus musculus	61-65
33263393-5	2020	The activity of the rac-1 was tested in mouse models of acute pain (hot plate) and severe tonic nociceptive stimulation (intraplantar formalin test).	Formaldehyde	134-142	Rac family small GTPase 1	Mus musculus	20-25
33263393-6	2020	Rac-1 was active in the formalin test with a reduction in paw licking in both phases at 10 mg/kg, and its effect was abolished by the selective 5-HT1AR antagonist, WAY-100635.	Formaldehyde	24-32	Rac family small GTPase 1	Mus musculus	0-5
33328587-8	2021	We found that degradation of FA by formaldehyde scavenger-NaHSO3 or coenzyme Q10 reduced Abeta aggregation and ameliorated the neurotoxicity, and improved the cognitive performance in APP/PS1 mice.	Formaldehyde	35-47	presenilin 1	Mus musculus	188-191
33106296-2	2020	We previously showed that formalin-killed spherules (FKS) stimulate mouse macrophages to secret MIP-2, which suggested that CXC ELR+ chemokines might be involved in neutrophil recruitment in vivo To test that hypothesis, we intra-nasally infected IL-8R2 (Cxcr2) deficient mice on a BALB/c background with C. immitis RS.	Formaldehyde	26-34	chemokine (C-X-C motif) ligand 2	Mus musculus	96-101
33106296-2	2020	We previously showed that formalin-killed spherules (FKS) stimulate mouse macrophages to secret MIP-2, which suggested that CXC ELR+ chemokines might be involved in neutrophil recruitment in vivo To test that hypothesis, we intra-nasally infected IL-8R2 (Cxcr2) deficient mice on a BALB/c background with C. immitis RS.	Formaldehyde	26-34	chemokine (C-X-C motif) receptor 2	Mus musculus	255-260
33270750-4	2020	ALCAM expression in 45 patients with MB was evaluated by immunohistochemical analysis of formalin-fixed paraffin-embedded clinical specimens and the relationship between ALCAM expression and pathological type/molecular subgroup, such as WNT, SHH, Group 3, and Group 4, was examined.	Formaldehyde	89-97	activated leukocyte cell adhesion molecule	Homo sapiens	0-5
32946866-4	2020	In the formalin test, ET1 reduced both neurogenic and inflammatory phase of nociception induced by the aldehyde.	Formaldehyde	7-15	endothelin 1	Mus musculus	22-25
33190709-1	2020	Formalin has been used as the preservative of fishes in the concentration range of 15-25 mgL-1.	Formaldehyde	0-8	LLGL scribble cell polarity complex component 1	Homo sapiens	89-94
33190709-7	2020	Dynamic sensing characteristics with varying formalin levels of 5-50 mgL-1 was studied in three different concentration ranges as 5-15 mgL-1 (concentration of formalin < NaCl; conversion of formalin to formic acid), 20-30 mgL-1 (concentration of formalin ~ NaCl; equilibrium between the oxidative and reductive product), 35-50 mgL-1 (concentration of formalin > NaCl; complete oxidation of formic acid to CO2).	Formaldehyde	45-53	LLGL scribble cell polarity complex component 1	Homo sapiens	69-74
33190709-9	2020	The threshold concentration of formalin required for the comparator effect was found to be 14.845 mgL-1.	Formaldehyde	31-39	LLGL scribble cell polarity complex component 1	Homo sapiens	98-103
31879078-9	2020	Finally, Todai OncoPanel, a next-generation sequencing-based molecular profiling system using formalin-fixed paraffin-embedded samples, demonstrated fusion transcript in which NAB2 exon 6 was fused to STAT6 exon 16 supporting the diagnosis of SFT, while whole-exome sequencing analysis detected no somatic mutations which were known to be oncogenic.	Formaldehyde	94-102	NGFI-A binding protein 2	Homo sapiens	176-180
31879078-9	2020	Finally, Todai OncoPanel, a next-generation sequencing-based molecular profiling system using formalin-fixed paraffin-embedded samples, demonstrated fusion transcript in which NAB2 exon 6 was fused to STAT6 exon 16 supporting the diagnosis of SFT, while whole-exome sequencing analysis detected no somatic mutations which were known to be oncogenic.	Formaldehyde	94-102	signal transducer and activator of transcription 6	Homo sapiens	201-206
33457012-6	2020	Methods: Expression of CLDN18.2 in 105 formalin-fixed, paraffin-embedded (FFPE) tumor tissues was detected by immunohistochemistry (IHC) and evaluated according to FAST criteria.	Formaldehyde	39-47	claudin 18	Homo sapiens	23-29
33080467-10	2020	GSK-3beta inhibition may play a role in glial cell activation, reducing pathological pain induced by nerve injury by formalin injection.	Formaldehyde	117-125	glycogen synthase kinase 3 alpha	Homo sapiens	0-9
32358715-2	2020	The goal of this meta-analysis was to perform a systematic review of studies using the VE1 clone (specific for detection of the BRAF V600E mutation) on formalin-fixed paraffin embedded (FFPE) thyroid surgical resection specimens for primary papillary thyroid carcinoma.	Formaldehyde	152-160	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	128-132
32835941-6	2020	Additionally, the expression levels of E-cadherin and Vimentin were also evaluated by immunohistochemistry using the formalin-fixed paraffin embedded canine oral SCC tissues, and the results show that the expression level of Vimentin in TSCC was higher than in NTSCC.	Formaldehyde	117-125	vimentin	Canis lupus familiaris	225-233
33037736-3	2020	Evaluation of formalin-fixed paraffin-embedded (FFPE) and frozen tissues of adenomas and CRCs, along with their corresponding normal samples, showed that TRIP13 was gradually increased in its phenotypic expression from adenoma to carcinoma, and that its overexpression in CRCs was independent of patient"s gender, age, race/ethnicity, pathologic stage, and p53 and microsatellite instability (MSI) status.	Formaldehyde	14-22	thyroid hormone receptor interactor 13	Homo sapiens	154-160
33123247-3	2020	Immunohistochemical staining for HER3 was performed using formalin-fixed paraffin-embedded surgical specimens and biopsy samples.	Formaldehyde	58-66	erb-b2 receptor tyrosine kinase 3	Homo sapiens	33-37
33425436-0	2020	Natural Killer and CD8 T Cells Contribute to Protection by Formalin Inactivated Respiratory Syncytial Virus Vaccination under a CD4-Deficient Condition.	Formaldehyde	59-67	CD8a molecule	Homo sapiens	19-22
33299472-2	2020	PD-L1 testing has been validated and is currently certified only on formalin-fixed paraffin-embedded materials but not on cytological smears.	Formaldehyde	68-76	CD274 molecule	Homo sapiens	0-5
33299472-10	2020	With the same cut-off, and assuming as gold-standard the results on formalin-fixed paraffin-embedded materials, PD-L1 evaluation on smears showed specificity and negative predictive values of 98.1% and 93.9%, respectively.	Formaldehyde	68-76	CD274 molecule	Homo sapiens	112-117
33437521-2	2020	Formalin-fixed, paraffin-embedded samples of 21 patients with solid tumors harboring MET alterations were used for immunohistochemical staining.	Formaldehyde	0-8	SAFB like transcription modulator	Homo sapiens	85-88
33425436-0	2020	Natural Killer and CD8 T Cells Contribute to Protection by Formalin Inactivated Respiratory Syncytial Virus Vaccination under a CD4-Deficient Condition.	Formaldehyde	59-67	CD4 molecule	Homo sapiens	128-131
33269348-5	2020	In a subset of this cohort we validated ACE2 protein expression and localization in formalin-fixed, paraffin-embedded matched colon and ileal tissues using immunohistochemistry.	Formaldehyde	84-92	angiotensin converting enzyme 2	Homo sapiens	40-44
33161980-5	2020	SECURA-3 was also unveiled as a potential probe that could replace its counterpart antibody in the histostaining-based detection of PTTG1 in HeLa and MCF-7 formalin-fixed paraffin-embedded cell blocks.	Formaldehyde	156-164	PTTG1 regulator of sister chromatid separation, securin	Homo sapiens	132-137
33292612-6	2020	LDLR expression was evaluated by immunohistochemistry on formalin-fixed paraffin-embedded tumor tissue.	Formaldehyde	57-65	low density lipoprotein receptor	Homo sapiens	0-4
33198632-4	2020	HER2 gene CNV was also assessed in formalin-fixed paraffin-embedded (FFPE) tumor tissue.	Formaldehyde	35-43	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-4
32869788-1	2020	On-line attenuated total reflection infrared spectroscopy (ATR-IR) was used to gain a good understanding of the kinetics and mechanism for methyl cyclopentenone (MCP) synthesis from 2-methylfuran and formaldehyde in a four-step reaction.	Formaldehyde	200-212	ATR serine/threonine kinase	Homo sapiens	59-62
33182484-5	2020	Formaldehyde-fixed paraffin-embedded material was stained for CD3 and CD8.	Formaldehyde	0-12	CD8a molecule	Homo sapiens	70-73
33175907-3	2020	Expression level of test microRNA (miR-182 and miR-18a) was determined using Taqman quantitative Real time polymerase chain reaction (qRT-PCR) from formalin fixed paraffin embedded biopsy blocks.	Formaldehyde	148-156	microRNA 182	Homo sapiens	25-42
32860265-3	2020	The GPA was evaluated using 67 formalin-fixed paraffin-embedded (FFPE) HER2 equivoval IHC (2+) breast cancer tissue samples.	Formaldehyde	31-39	erb-b2 receptor tyrosine kinase 2	Homo sapiens	71-75
33017153-4	2020	In this study, we aimed to further elucidate the reaction products of formaldehyde reaction with proteins and report unique modifications in formaldehyde-treated cytochrome c and corresponding synthetic peptides.	Formaldehyde	70-82	cytochrome c, somatic	Homo sapiens	162-174
33017153-4	2020	In this study, we aimed to further elucidate the reaction products of formaldehyde reaction with proteins and report unique modifications in formaldehyde-treated cytochrome c and corresponding synthetic peptides.	Formaldehyde	141-153	cytochrome c, somatic	Homo sapiens	162-174
32861163-10	2020	In conclusion, our findings suggested that PM2.5 and formaldehyde may induce hematopoietic toxicity by reducing the expression of hematopoietic growth factors, increasing oxidative stress and DNA damage, activating the "immune imbalance" pathway and suppressing the DNA-repair related mTOR pathway.	Formaldehyde	53-65	mechanistic target of rapamycin kinase	Homo sapiens	285-289
32519799-0	2020	Metformin scavenges formaldehyde and attenuates formaldehyde-induced bovine serum albumin crosslinking and cellular DNA damage.	Formaldehyde	48-60	albumin	Homo sapiens	76-89
33245030-5	2020	Semiquantitative gene expression for MACC1 was evaluated using formalin-fixed paraffin-embedded sections and unfixed tumour samples from primary Rb cases (n = 44).	Formaldehyde	63-71	MET transcriptional regulator MACC1	Homo sapiens	37-42
32798733-6	2020	These results demonstrated that co-exposure to formaldehyde and low temperature exacerbate allergic asthma, and that TRPM8 and TRPA1 are involved in this process.	Formaldehyde	47-59	transient receptor potential cation channel, subfamily M, member 8	Mus musculus	117-122
32798733-6	2020	These results demonstrated that co-exposure to formaldehyde and low temperature exacerbate allergic asthma, and that TRPM8 and TRPA1 are involved in this process.	Formaldehyde	47-59	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	127-132
32307573-5	2020	CTNNB1-PLAG1 gene fusion was identified by reverse transcription-polymerase chain reaction using formalin-fixed paraffin-embedded tissue (FFPE).	Formaldehyde	97-105	catenin beta 1	Homo sapiens	0-6
32307573-5	2020	CTNNB1-PLAG1 gene fusion was identified by reverse transcription-polymerase chain reaction using formalin-fixed paraffin-embedded tissue (FFPE).	Formaldehyde	97-105	PLAG1 zinc finger	Homo sapiens	7-12
33134597-2	2020	Methods: Immunohistochemistry was performed to evaluate the expression of MMR proteins (MLH1, MSH2, MSH6, and PMS2) in formalin-fixed paraffin-embedded sections prepared from surgically resected primary SBCs from 30 patients during March 2002 to March 2017.	Formaldehyde	119-127	mutL homolog 1	Homo sapiens	88-92
33134597-2	2020	Methods: Immunohistochemistry was performed to evaluate the expression of MMR proteins (MLH1, MSH2, MSH6, and PMS2) in formalin-fixed paraffin-embedded sections prepared from surgically resected primary SBCs from 30 patients during March 2002 to March 2017.	Formaldehyde	119-127	mutS homolog 2	Homo sapiens	94-98
33134597-2	2020	Methods: Immunohistochemistry was performed to evaluate the expression of MMR proteins (MLH1, MSH2, MSH6, and PMS2) in formalin-fixed paraffin-embedded sections prepared from surgically resected primary SBCs from 30 patients during March 2002 to March 2017.	Formaldehyde	119-127	mutS homolog 6	Homo sapiens	100-104
33119552-4	2020	RESULTS Analysis of the RNA-Seq data from the TCGA (The Cancer Genome Atlas) MIBC cohort (n=408) revealed that CEP78 was overexpressed in tumor tissues, which was confirmed with fresh-frozen and formalin-fixed paraffin-embedded specimens collected from 28 and 33 MIBC patients, respectively, in the present study.	Formaldehyde	195-203	centrosomal protein 78	Homo sapiens	111-116
33134597-2	2020	Methods: Immunohistochemistry was performed to evaluate the expression of MMR proteins (MLH1, MSH2, MSH6, and PMS2) in formalin-fixed paraffin-embedded sections prepared from surgically resected primary SBCs from 30 patients during March 2002 to March 2017.	Formaldehyde	119-127	PMS1 homolog 2, mismatch repair system component	Homo sapiens	110-114
32989163-0	2020	Distinct RNA N-demethylation pathways catalyzed by nonheme iron ALKBH5 and FTO enzymes enable regulation of formaldehyde release rates.	Formaldehyde	108-120	alkB homolog 5, RNA demethylase	Homo sapiens	64-70
33193888-4	2020	Materials & Methods: Both tumoral and stromal immune PD-L1 expression in formalin-fixed, paraffin-embedded tumor samples from 233 breast cancer patients without initial stage IV metastases were evaluated by immunohistochemistry using a mouse monoclonal anti-PDL1 antibody.	Formaldehyde	73-81	CD274 molecule	Homo sapiens	53-58
32876438-5	2020	Using this strategy, DOX-mediated cytotoxicity in Fanconi anemia group gene (FANC)/breast cancer susceptibility gene (BRCA)-deficient cells increased up to 70-fold compared to that in cells proficient in DNA repair pathways by increasing intracellular formaldehyde (FA) concentration.	Formaldehyde	252-264	BRCA1 DNA repair associated	Homo sapiens	118-122
32989163-1	2020	The AlkB family of nonheme Fe(II)/2-oxoglutarate-dependent oxygenases are essential regulators of RNA epigenetics by serving as erasers of one-carbon marks on RNA with release of formaldehyde (FA).	Formaldehyde	179-191	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	4-8
32989163-0	2020	Distinct RNA N-demethylation pathways catalyzed by nonheme iron ALKBH5 and FTO enzymes enable regulation of formaldehyde release rates.	Formaldehyde	108-120	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	75-78
33046725-0	2020	Formaldehyde exposure induces regulatory T cell-mediated immunosuppression via calcineurin-NFAT signalling pathway.	Formaldehyde	0-12	nuclear factor of activated T cells 2	Homo sapiens	91-95
33029912-6	2021	METHODS: Real-time RT-PCR was applied to evaluate hsa-miR-27a-3p and EGFR expressions in the formalin-fixed paraffin-embedded (FFPE) tissue samples obtained from 50 GBM and 50 normal people.	Formaldehyde	93-101	albumin	Homo sapiens	50-53
33029912-6	2021	METHODS: Real-time RT-PCR was applied to evaluate hsa-miR-27a-3p and EGFR expressions in the formalin-fixed paraffin-embedded (FFPE) tissue samples obtained from 50 GBM and 50 normal people.	Formaldehyde	93-101	epidermal growth factor receptor	Homo sapiens	69-73
32442852-1	2020	To develop a novel adsorbent that can efficiently and rapidly recover gold from the leaching solution of electronic appliances, thiourea-resorcinol-formaldehyde resin microspheres (TRF) were prepared by a one-pot solvothermal method.	Formaldehyde	148-160	telomeric repeat binding factor 1	Homo sapiens	181-184
33001186-6	2020	METHODS: We quantified HER2 expression levels in 210 breast cancer formalin-fixed paraffin-embedded (FFPE) tissue samples by MRM-MS. We aimed to improve the accuracy and precision of HER2 quantification by simplifying the sample preparation through predicting the number of FFPE slides required to ensure an adequate amount of protein and using the expression levels of an epithelial cell-specific protein as a normalization factor when measuring HER2 expression levels.	Formaldehyde	67-75	erb-b2 receptor tyrosine kinase 2	Homo sapiens	23-27
33163276-4	2020	We applied single and double immunohistochemistry to analyze spatial relationships between CD8+, FoxP3+ and CD20+ tumor-infiltrating lymphocytes (TILs) and the cells expressing Zeb1 in formalin-fixed, paraffin-embedded surgical specimens of 113 TNBCs.	Formaldehyde	185-193	zinc finger E-box binding homeobox 1	Homo sapiens	177-181
32806450-6	2020	Varying by species, FADH and WSS peaked at certain formaldehyde concentrations.	Formaldehyde	51-63	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	20-24
32659531-5	2020	Co-exposure to formaldehyde and acrolein mixtures showed significantly synergistic interaction on DNA strands breakage and chromosome damage in a concentration/time-dependent manner, while antagonism was shown on the late genotoxic endpoints (e.g. cytoplasmic block micronucleus (CBMN) and HPRT gene mutation).	Formaldehyde	15-27	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	290-294
32451170-4	2020	MATERIALS AND METHODS: TP53 was PCR amplified using the genomic DNA extracted from peripheral blood mononuclear cells and formalin-fixed, paraffin-embedded tissue sections from the tumor site of the patient, and was sequenced.	Formaldehyde	122-130	tumor protein p53	Homo sapiens	23-27
32772316-2	2020	METHODS: We designed single-molecule molecular inversion probes to target 18 MTOR somatic mutational hot-spots in unmatched, histologically proven focal cortical dysplasias from formalin-fixed, paraffin-embedded tissues of 50 patients.	Formaldehyde	178-186	mechanistic target of rapamycin kinase	Homo sapiens	77-81
32446898-6	2020	The isolated fucoidan could significantly decreased the MDA and also increase the SOD, CAT, GPx, GST and GSH activity in paw edema tissue of formalin injected mice.	Formaldehyde	141-149	catalase	Mus musculus	87-90
32446898-6	2020	The isolated fucoidan could significantly decreased the MDA and also increase the SOD, CAT, GPx, GST and GSH activity in paw edema tissue of formalin injected mice.	Formaldehyde	141-149	peroxiredoxin 6 pseudogene 2	Mus musculus	92-95
32621174-4	2020	We developed an amplicon-based panel to detect human epidermal receptor growth factor (HER2) amplification in formalin-fixed paraffin-embedded (FFPE) tumor tissue samples from 280 breast cancer and 50 gastric cancer patients.	Formaldehyde	110-118	erb-b2 receptor tyrosine kinase 2	Homo sapiens	87-91
32802162-5	2020	Immunohistochemical staining for HER3 was performed on formalin-fixed paraffin-embedded surgical specimens.	Formaldehyde	55-63	erb-b2 receptor tyrosine kinase 3	Homo sapiens	33-37
32735340-2	2020	Studies with heavy isotope labelled [13CD2]-formaldehyde permit quantification of both the mass-labelled exogenous and endogenous DNA-formaldehyde reaction products.	Formaldehyde	44-56	Cd2 molecule	Rattus norvegicus	39-42
32735340-2	2020	Studies with heavy isotope labelled [13CD2]-formaldehyde permit quantification of both the mass-labelled exogenous and endogenous DNA-formaldehyde reaction products.	Formaldehyde	134-146	Cd2 molecule	Rattus norvegicus	39-42
32735340-5	2020	The existing kinetic model overpredicted endogenous adducts in the nasal epithelium after 1-day [13CD2]-formaldehyde exposure, requiring adjustment of parameters for rates of tissue metabolism and background formaldehyde.	Formaldehyde	104-116	Cd2 molecule	Rattus norvegicus	99-102
32976996-4	2020	In a dose-dependent manner, formaldehyde led to reduced exploratory behavior (open-field), deficits in learning and memory (MWM and step-down avoidance test), and reduced expression of Ng, CaMKII, and PKC mRNA, as well as Ng protein.	Formaldehyde	28-40	neurogranin	Rattus norvegicus	185-187
33071817-8	2020	Both C1 and MCD had inhibitory action on TRPA1 activation (formalin)-induced acute nocifensive reactions (paw liftings, lickings, holdings, and shakings) in the second, neurogenic inflammatory phase by 36% and 51%, respectively.	Formaldehyde	59-67	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	41-46
32976996-4	2020	In a dose-dependent manner, formaldehyde led to reduced exploratory behavior (open-field), deficits in learning and memory (MWM and step-down avoidance test), and reduced expression of Ng, CaMKII, and PKC mRNA, as well as Ng protein.	Formaldehyde	28-40	protein kinase C, gamma	Rattus norvegicus	201-204
32976996-4	2020	In a dose-dependent manner, formaldehyde led to reduced exploratory behavior (open-field), deficits in learning and memory (MWM and step-down avoidance test), and reduced expression of Ng, CaMKII, and PKC mRNA, as well as Ng protein.	Formaldehyde	28-40	neurogranin	Rattus norvegicus	222-224
32938960-0	2020	Formalin-fixed paraffin-embedded renal biopsy tissues: an underexploited biospecimen resource for gene expression profiling in IgA nephropathy.	Formaldehyde	0-8	immunoglobulin heavy variable 4-38-2-like	Homo sapiens	127-130
33072501-4	2020	Methods: Expression profiles of DNMT1 were investigated in fresh frozen tissues, patient-derived cells, and formalin-fixed paraffin-embedded tissues using immunoblotting and immunohistochemistry analysis.	Formaldehyde	108-116	DNA methyltransferase 1	Homo sapiens	32-37
32844841-8	2020	The recombination of beta-isobutanol radical with O2 forms a stabilized hydroperoxy alkyl radical below 400 K, water + an alkoxy radical at higher temperatures, and HO2 + an alkene above 1200 K. The recombination of beta-isobutanol radical with O2 results in a mixture of products between 700-1100 K, forming acetone + formaldehyde + OH at lower temperatures and forming HO2 + alkenes at higher temperatures.	Formaldehyde	319-331	heme oxygenase 2	Homo sapiens	371-374
33042836-2	2020	Methods: Using immunohistochemistry, the expression of B7-H3 was detected in a total of 213 formalin-fixed paraffin-embedded CRC tissue specimens.	Formaldehyde	92-100	CD276 molecule	Homo sapiens	55-60
32786431-3	2020	We confirmed that the side modification is caused by formaldehyde released from the spin filter and found that the side modification leads to 10.5% and 9.5% loss in proteome-level peptide and protein identification, respec-tively.	Formaldehyde	53-65	spindlin 1	Homo sapiens	84-88
32469018-10	2020	If we add 1 monolayer equivalent of Mo to the surface there is already high selectivity to formaldehyde, but little change in structure, because that monolayer is isolated at the surface.	Formaldehyde	91-103	adducin 1	Homo sapiens	6-11
32887625-0	2020	Mass spectrometry-based analysis of formalin-fixed, paraffin-embedded distal cholangiocarcinoma identifies stromal thrombospondin-2 as a potential prognostic marker.	Formaldehyde	36-44	thrombospondin 2	Homo sapiens	115-131
33013308-4	2020	The aim of this study was to investigate the effect of the peripheral injection of (pyr)apelin-13 on inflammatory pain using the formalin test as well as to evaluate the mechanistic basis for the effect.	Formaldehyde	129-137	apelin	Homo sapiens	88-94
33013308-6	2020	injection of (pyr)apelin-13 (10, 20 mg/kg) to significantly decrease licking/biting time during the second phase of the mouse formalin test.	Formaldehyde	126-134	apelin	Mus musculus	18-24
32615158-8	2020	LH chemical stimulation-induced antinociception during both phases of the formalin test was alleviated by the intra-CA1 administration of dopamine receptor antagonists.	Formaldehyde	74-82	carbonic anhydrase 1	Rattus norvegicus	116-119
32886667-5	2020	Immunohistochemistry for IDH1-R132H was done on 5-microns-thick formalin-fixed, paraffin-embedded tumor sections with the use of antibody specific for the mutant IDH1-R132H protein.	Formaldehyde	64-72	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	25-29
32986351-5	2020	SNPs genotyping was performed using TaqMan SNP Genotyping Assay and the results were correlated with KAI1 protein expression profile by immunohistochemistry (IHC) on formalin-fixed paraffin-embedded (FFPE) samples of breast cancer and control none-neoplastic tissues.	Formaldehyde	166-174	CD82 molecule	Homo sapiens	101-105
32911587-4	2020	In this study, we examined the levels of expression of Bcl-2 and Bax in mice treated with formalin and L-carnitine.	Formaldehyde	90-98	B cell leukemia/lymphoma 2	Mus musculus	55-60
32911587-4	2020	In this study, we examined the levels of expression of Bcl-2 and Bax in mice treated with formalin and L-carnitine.	Formaldehyde	90-98	BCL2-associated X protein	Mus musculus	65-68
32911587-9	2020	RESULTS: The expression of Bax was significantly higher in the formalin-treated mice than in the mice of the control group, while the expression of Bcl-2 was significantly lower in the formalin-treated mice than in the control mice.	Formaldehyde	63-71	BCL2-associated X protein	Mus musculus	27-30
32911587-9	2020	RESULTS: The expression of Bax was significantly higher in the formalin-treated mice than in the mice of the control group, while the expression of Bcl-2 was significantly lower in the formalin-treated mice than in the control mice.	Formaldehyde	185-193	B cell leukemia/lymphoma 2	Mus musculus	148-153
32911587-10	2020	Additionally, relative to control mice, Bcl-2 expression increased and Bax expression decreased in the mice administered both formalin and L-carnitine.	Formaldehyde	126-134	B cell leukemia/lymphoma 2	Mus musculus	40-45
32911587-10	2020	Additionally, relative to control mice, Bcl-2 expression increased and Bax expression decreased in the mice administered both formalin and L-carnitine.	Formaldehyde	126-134	BCL2-associated X protein	Mus musculus	71-74
32533878-4	2020	Tat induction significantly attenuated the time spent paw-licking following formalin injection (2.5%, i.pl.)	Formaldehyde	76-84	tyrosine aminotransferase	Mus musculus	0-3
32467309-5	2020	Using an RBP (CASC3) and an RAF (RNPS1) within the exon junction complex (EJC) as examples, we show that formaldehyde crosslinking combined with RNA immunoprecipitation in tandem followed by sequencing (xRIPiT-seq) far exceeds CLIP-seq to identify binding sites of RNPS1.	Formaldehyde	105-117	SURP and G-patch domain containing 1	Homo sapiens	9-12
32683856-4	2020	Materials and Methods: Formalin-fixed paraffin-embedded tissue sections were used for p16 IHC and DNA extraction.	Formaldehyde	23-31	cyclin dependent kinase inhibitor 2A	Homo sapiens	86-89
32754325-2	2020	Reverse transcription-quantitative PCR was used to quantify the mRNA expression levels of HIF-1alpha, HIF-2alpha, prolyl hydroxylase (PHD)1, PHD2 and PHD3 in formalin-fixed paraffin-embedded (FFPE) tumour tissue samples from 41 patients with RCC, including 33 cases of clear cell RCC (ccRCC).	Formaldehyde	158-166	hypoxia inducible factor 1 subunit alpha	Homo sapiens	90-100
32754325-2	2020	Reverse transcription-quantitative PCR was used to quantify the mRNA expression levels of HIF-1alpha, HIF-2alpha, prolyl hydroxylase (PHD)1, PHD2 and PHD3 in formalin-fixed paraffin-embedded (FFPE) tumour tissue samples from 41 patients with RCC, including 33 cases of clear cell RCC (ccRCC).	Formaldehyde	158-166	endothelial PAS domain protein 1	Homo sapiens	102-112
32754325-2	2020	Reverse transcription-quantitative PCR was used to quantify the mRNA expression levels of HIF-1alpha, HIF-2alpha, prolyl hydroxylase (PHD)1, PHD2 and PHD3 in formalin-fixed paraffin-embedded (FFPE) tumour tissue samples from 41 patients with RCC, including 33 cases of clear cell RCC (ccRCC).	Formaldehyde	158-166	egl-9 family hypoxia inducible factor 1	Homo sapiens	141-145
32754325-2	2020	Reverse transcription-quantitative PCR was used to quantify the mRNA expression levels of HIF-1alpha, HIF-2alpha, prolyl hydroxylase (PHD)1, PHD2 and PHD3 in formalin-fixed paraffin-embedded (FFPE) tumour tissue samples from 41 patients with RCC, including 33 cases of clear cell RCC (ccRCC).	Formaldehyde	158-166	egl-9 family hypoxia inducible factor 3	Homo sapiens	150-154
32673629-4	2020	Microinjection of the selective GPR55 antagonist CID16020046 into the ACC of adult male Sprague-Dawley rats significantly reduced second phase formalin-evoked nociceptive behaviour compared with vehicle-treated controls.	Formaldehyde	143-151	G protein-coupled receptor 55	Rattus norvegicus	32-37
32673629-6	2020	Intra-ACC administration of CID16020046 prevented the formalin-induced increases in expression of mRNA coding for the immediate early gene and marker of neuronal activity, c-Fos, in the ipsilateral dorsal horn of the spinal cord.	Formaldehyde	54-62	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	172-177
32673629-7	2020	Intra-plantar injection of formalin reduced tissue levels of the endogenous GPR55 ligand 2-arachidonoyl-sn-glycero-3-phosphoinositol (2-AGPI) in the ACC, likely reflecting its increased release/utilisation.	Formaldehyde	27-35	G protein-coupled receptor 55	Rattus norvegicus	76-81
32467309-5	2020	Using an RBP (CASC3) and an RAF (RNPS1) within the exon junction complex (EJC) as examples, we show that formaldehyde crosslinking combined with RNA immunoprecipitation in tandem followed by sequencing (xRIPiT-seq) far exceeds CLIP-seq to identify binding sites of RNPS1.	Formaldehyde	105-117	CASC3 exon junction complex subunit	Homo sapiens	14-19
32467309-5	2020	Using an RBP (CASC3) and an RAF (RNPS1) within the exon junction complex (EJC) as examples, we show that formaldehyde crosslinking combined with RNA immunoprecipitation in tandem followed by sequencing (xRIPiT-seq) far exceeds CLIP-seq to identify binding sites of RNPS1.	Formaldehyde	105-117	zinc fingers and homeoboxes 2	Homo sapiens	28-31
32467309-5	2020	Using an RBP (CASC3) and an RAF (RNPS1) within the exon junction complex (EJC) as examples, we show that formaldehyde crosslinking combined with RNA immunoprecipitation in tandem followed by sequencing (xRIPiT-seq) far exceeds CLIP-seq to identify binding sites of RNPS1.	Formaldehyde	105-117	RNA binding protein with serine rich domain 1	Homo sapiens	33-38
32467309-5	2020	Using an RBP (CASC3) and an RAF (RNPS1) within the exon junction complex (EJC) as examples, we show that formaldehyde crosslinking combined with RNA immunoprecipitation in tandem followed by sequencing (xRIPiT-seq) far exceeds CLIP-seq to identify binding sites of RNPS1.	Formaldehyde	105-117	RNA binding protein with serine rich domain 1	Homo sapiens	265-270
32461131-1	2020	Previous studies have demonstrated that continuous substance P (SP) infusion into the rat striatum attenuated hind paw formalin-induced nociceptive behaviors and mechanical hypersensitivity via a neurokinin-1 (NK1) receptor dependent mechanism.	Formaldehyde	119-127	tachykinin receptor 1	Rattus norvegicus	196-223
32867667-6	2021	METHOD: The immunohistochemical expression of KMT2C/MLL3, H3K4me2 and H3K4me3 was analyzed in formalin fixed paraffin embedded tissue from 96 patients with lung adenocarcinoma.	Formaldehyde	94-102	lysine methyltransferase 2C	Homo sapiens	46-51
32847623-2	2020	This study aimed at investigating the immunohistochemical expression of PAX-8 among Sudanese females diagnosed with cervical, endometrial, and ovarian cancers between December 2017 and May 2019 by studying their Formalin-fixed paraffin embedded blocks.	Formaldehyde	212-220	paired box 8	Homo sapiens	72-77
32820309-5	2020	Moreover, in the brains of normal aged rats and APP/PS1 transgenic mice, the concentrations of formaldehyde were abnormally increased, which directly inhibited NMDA receptor activity and impaired spatial memory.	Formaldehyde	95-107	presenilin 1	Rattus norvegicus	52-55
32903564-4	2020	Somatic BRCA1/2 mutation analysis was performed by next-generation sequencing on the DNA extracted from a formalin-fixed, paraffin-embedded CCA biopsy specimen of their mother.	Formaldehyde	106-114	BRCA1 DNA repair associated	Homo sapiens	8-15
32872479-0	2020	Oriented Carbon Nanostructures from Plasma Reformed Resorcinol-Formaldehyde Polymer Gels for Gas Sensor Applications.	Formaldehyde	63-75	gastrin	Homo sapiens	93-96
32449514-6	2020	SOAT1 protein expression was determined by immunohistochemistry on formalin-fixed paraffin-embedded specimens.	Formaldehyde	67-75	sterol O-acyltransferase 1	Homo sapiens	0-5
32856862-4	2020	BRCA1/2 mutations were detected from formalin-fixed parafin-embedded tumor samples using the OncomineTM BRCA Research Assay on Personal Genome Machine Platform with Ion Reporter Software for sequencing data analysis.	Formaldehyde	37-45	BRCA1 DNA repair associated	Homo sapiens	0-7
32416209-2	2020	Studies conducted on formalin-fixed paraffin-embedded (FFPE) tissue have found that nuclear expression of a monoclonal antibody NR4A3 (NOR-1) is a sensitive and specific diagnostic marker for ACC-SG.	Formaldehyde	21-29	nuclear receptor subfamily 4 group A member 3	Homo sapiens	128-133
32416209-2	2020	Studies conducted on formalin-fixed paraffin-embedded (FFPE) tissue have found that nuclear expression of a monoclonal antibody NR4A3 (NOR-1) is a sensitive and specific diagnostic marker for ACC-SG.	Formaldehyde	21-29	nuclear receptor subfamily 4 group A member 3	Homo sapiens	135-140
32553554-4	2020	MATERIALS AND METHODS: We verify ALK expression and rearrangement on formalin-fixed paraffin-embedded tumor samples of the patient by Immunohistochemistry and Fluorescence In Situ Hybridization analysis.	Formaldehyde	69-77	ALK receptor tyrosine kinase	Homo sapiens	33-36
32534365-3	2020	METHOD AND RESULTS: We examined 86 thyroid lymphoma cases using fluorescence in situ hybridization (FISH) for the detection of t(3;14)/FOXP1-IGH in formalin fixed paraffin-embedded tissue (FFPE).	Formaldehyde	148-156	forkhead box P1	Homo sapiens	135-140
32534365-3	2020	METHOD AND RESULTS: We examined 86 thyroid lymphoma cases using fluorescence in situ hybridization (FISH) for the detection of t(3;14)/FOXP1-IGH in formalin fixed paraffin-embedded tissue (FFPE).	Formaldehyde	148-156	immunoglobulin heavy locus	Homo sapiens	141-144
32732905-7	2020	The significance of sensory neuron targeting was pursued subsequently by testing C2C activity in the formalin inflammatory mouse pain model.	Formaldehyde	101-109	secretoglobin, family 2B, member 20	Mus musculus	81-84
32543087-0	2020	Clinical evaluation of the effectiveness of fusion-induced asymmetric transcription assay-based reverse transcription droplet digital PCR for ALK detection in formalin-fixed paraffin-embedded samples from lung cancer.	Formaldehyde	159-167	ALK receptor tyrosine kinase	Homo sapiens	142-145
32436149-4	2020	AR status was detected by immunohistochemistry on formalin-fixed, paraffin-embedded tumoral tissue sections.	Formaldehyde	50-58	androgen receptor	Homo sapiens	0-2
32717961-0	2020	Acyclic Triterpenoid Isolated from Alpinia katsumadai Alleviates Formalin-Induced Chronic Mouse Paw Inflammation by Inhibiting the Phosphorylation of ERK and NF-kappaB.	Formaldehyde	65-73	mitogen-activated protein kinase 1	Mus musculus	150-153
32717961-0	2020	Acyclic Triterpenoid Isolated from Alpinia katsumadai Alleviates Formalin-Induced Chronic Mouse Paw Inflammation by Inhibiting the Phosphorylation of ERK and NF-kappaB.	Formaldehyde	65-73	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	158-167
32774739-5	2020	Immunohistochemistry (IHC) was performed to analyze the expression of PCK2 in formalin-fixed paraffin-embedded (FFPE) tissue sections, including laryngeal squamous cell carcinoma tissues from various stages.	Formaldehyde	78-86	phosphoenolpyruvate carboxykinase 2 (mitochondrial)	Mus musculus	70-74
32674482-3	2020	We analyzed ERBB2 expression using a clinically applicable assay in formalin-fixed paraffin-embedded (FFPE) tumors (primary or metastatic) from a retrospective series of 77 patients with advanced HER2+ BC treated with T-DM1.	Formaldehyde	68-76	erb-b2 receptor tyrosine kinase 2	Homo sapiens	12-17
32569467-3	2020	In situ trapping of NOx and formaldehyde suggest an oxidative Nef process reminiscent of flavoprotein nitroalkane oxidase reactivity, which is achieved by relatively stable 1,10-bridged flavins.	Formaldehyde	28-40	S100 calcium binding protein B	Homo sapiens	62-65
32143129-2	2020	The sensor limit of detection for formaldehyde was 0.2 mg L-1, and the limit of quantification was 0.6 mg L-1, which were close to the conventional spectrophotometric method values of 0.2 mg L-1 and 0.5 mg L-1, respectively, and lower than the tolerable limit for ingested food.	Formaldehyde	34-46	immunoglobulin kappa variable 1-16	Homo sapiens	58-61
32665578-0	2020	Formaldehyde treatment of proteins enhances proteolytic degradation by the endo-lysosomal protease cathepsin S.	Formaldehyde	0-12	cathepsin S	Homo sapiens	99-110
33659347-6	2020	Herein, using tyramide signal amplification (TSA), we present two protocols for the IF detection of MYCN and MYC on formalin-fixed paraffin embedded (FFPE) tumor sections and in cell lines fixed in situ after growth as adherent cultures on chambered microscope slides.	Formaldehyde	116-124	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	100-104
33659347-6	2020	Herein, using tyramide signal amplification (TSA), we present two protocols for the IF detection of MYCN and MYC on formalin-fixed paraffin embedded (FFPE) tumor sections and in cell lines fixed in situ after growth as adherent cultures on chambered microscope slides.	Formaldehyde	116-124	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	100-103
32514323-0	2020	The failure of two major formaldehyde catabolism enzymes (ADH5 and ALDH2) leads to partial synthetic lethality in C57BL/6 mice.	Formaldehyde	25-37	alcohol dehydrogenase 5 (class III), chi polypeptide	Mus musculus	58-62
32213302-8	2020	In vivo, RB-TNFSF15 gene expression was up-regulated in head kidney, liver and blood after vaccination with a formalin inactivated RBIV.	Formaldehyde	110-118	TNF superfamily member 15	Homo sapiens	12-19
32132394-8	2020	The Scn11a mice showed increased sensitivity to mechanical, heat and cold stimuli, and hypersensitivity to acetaldehyde and formalin, which could account for the alcohol intake-induced pain phenotype in patients.	Formaldehyde	124-132	sodium channel, voltage-gated, type XI, alpha	Mus musculus	4-10
32444257-4	2020	Formalin-fixed paraffin-embedded tissues were used for immunohistochemical study for oestrogen receptors and HIF-1a proteins.	Formaldehyde	0-8	hypoxia inducible factor 1 subunit alpha	Homo sapiens	109-115
32589683-0	2020	Participation of TDP1 in the repair of formaldehyde-induced DNA-protein cross-links in chicken DT40 cells.	Formaldehyde	39-51	tyrosyl-DNA phosphodiesterase 1	Gallus gallus	17-21
32589683-4	2020	In the present study, we examined the contribution of TDP1 to the repair of formaldehyde-induced DPCs using a reverse genetic strategy with chicken DT40 cells.	Formaldehyde	76-88	tyrosyl-DNA phosphodiesterase 1	Gallus gallus	54-58
32589683-5	2020	The results obtained showed that cells deficient in TDP1 were sensitive to formaldehyde.	Formaldehyde	75-87	tyrosyl-DNA phosphodiesterase 1	Gallus gallus	52-56
32589683-6	2020	The removal of formaldehyde-induced DPCs was slower in tdp1-deficient cells than in wild type cells.	Formaldehyde	15-27	tyrosyl-DNA phosphodiesterase 1	Gallus gallus	55-59
32589683-8	2020	The formaldehyde treatment resulted in the accumulation of chromosomal breakages that were more prominent in tdp1-deficient cells than in wild type cells.	Formaldehyde	4-16	tyrosyl-DNA phosphodiesterase 1	Gallus gallus	109-113
32589683-9	2020	Therefore, TDP1 plays a critical role in the repair of formaldehyde-induced DPCs that are distinct from trapped TOPO1.	Formaldehyde	55-67	tyrosyl-DNA phosphodiesterase 1	Gallus gallus	11-15
32019278-5	2020	Exon 9 and exon 20 of PIK3CA mutations were evaluated by using classical Sanger method with formalin-fixed paraffin-embedded tumor tissues.	Formaldehyde	92-100	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	22-28
32706079-11	2020	Furthermore, melatonin decreased the formalin-evoked elevated nNOS mRNA and protein levels in the TG and Vc neurons in the acute and chronic phases (p < 0.05).	Formaldehyde	37-45	nitric oxide synthase 1	Rattus norvegicus	62-66
31771972-3	2020	The aim of this study was to compare the immunohistochemical expression of PRDX3 in formalin-fixed, paraffin-embedded (FFPE) primary UM tissues of patients who did and did not develop metastatic disease.	Formaldehyde	84-92	peroxiredoxin 3	Homo sapiens	75-80
31872868-5	2020	After viral, caspase-mediated ablation of spinal ERalpha-expressing cells, we observed a significant decrease in the first phase of the formalin test, but in male mice only.	Formaldehyde	136-144	estrogen receptor 1 (alpha)	Mus musculus	49-56
32404253-2	2020	STUDY DESIGN: Mutations in promoter region of the TERT gene were analyzed with polymerase chain reaction-based direct sequencing method using formalin-fixed, paraffin-embedded tumor samples of 189 HNSCCs.	Formaldehyde	142-150	telomerase reverse transcriptase	Homo sapiens	50-54
32612190-4	2020	Among this category of compounds, an appreciably potent anti-inflammatory agent exhibiting IC50 0.06 muM against COX-2 and reversing the formalin induced analgesia and carageenan induced inflammation in mice by 90% was identified.	Formaldehyde	137-145	prostaglandin-endoperoxide synthase 2	Mus musculus	113-118
32560654-7	2020	mRNA for gene expression analysis of AR and steroidogenic enzymes was extracted from formalin-fixed paraffin embedded (FFPE) tissues and analyzed by real-time PCR.	Formaldehyde	85-93	androgen receptor	Homo sapiens	37-39
32514323-0	2020	The failure of two major formaldehyde catabolism enzymes (ADH5 and ALDH2) leads to partial synthetic lethality in C57BL/6 mice.	Formaldehyde	25-37	aldehyde dehydrogenase 2, mitochondrial	Mus musculus	67-72
32514323-4	2020	In this study, we attempted to generate C57BL/6 mice deficient in both Adh5 and Aldh2, which encode two major enzymes that metabolize endogenous formaldehyde, in order to understand the effects of endogenous formaldehyde on mice with normal DNA repair function.	Formaldehyde	145-157	alcohol dehydrogenase 5 (class III), chi polypeptide	Mus musculus	71-75
32514323-4	2020	In this study, we attempted to generate C57BL/6 mice deficient in both Adh5 and Aldh2, which encode two major enzymes that metabolize endogenous formaldehyde, in order to understand the effects of endogenous formaldehyde on mice with normal DNA repair function.	Formaldehyde	145-157	aldehyde dehydrogenase 2, mitochondrial	Mus musculus	80-85
32514323-10	2020	Conclusion: Mice deficient in both formaldehyde-metabolizing enzymes ADH5 and ALDH2 were found to develop partial synthetic lethality and mortality shortly after birth.	Formaldehyde	35-47	alcohol dehydrogenase 5 (class III), chi polypeptide	Mus musculus	69-73
32514323-10	2020	Conclusion: Mice deficient in both formaldehyde-metabolizing enzymes ADH5 and ALDH2 were found to develop partial synthetic lethality and mortality shortly after birth.	Formaldehyde	35-47	aldehyde dehydrogenase 2, mitochondrial	Mus musculus	78-83
32514323-13	2020	It is important to further investigate these diseases in individuals with ALDH2*2 alleles, including an association with decreased metabolism, and thus accumulation, of formaldehyde.	Formaldehyde	169-181	aldehyde dehydrogenase 2 family member	Homo sapiens	74-79
32079442-5	2020	PD-L1 expression was evaluated by immunohistochemistry on formalin fixed, paraffin embedded tissue sections.	Formaldehyde	58-66	CD274 molecule	Homo sapiens	0-5
32314446-0	2020	Combination of KRAS and SMAD4 mutations in formalin-fixed paraffin-embedded tissues as a biomarker for pancreatic cancer.	Formaldehyde	43-51	SMAD family member 4	Homo sapiens	24-29
32011345-3	2020	BCOR immunohistochemistry was performed on archival formalin-fixed paraffin-embedded tumor tissue in 13 of 14 adenosarcomas with and without stromal overgrowth arising in the uterus or ovary.	Formaldehyde	52-60	BCL6 corepressor	Homo sapiens	0-4
32335808-0	2020	TNFAIP1 Mediates Formaldehyde-Induced Neurotoxicity by Inhibiting the Akt/CREB Pathway in N2a Cells.	Formaldehyde	17-29	tumor necrosis factor, alpha-induced protein 1 (endothelial)	Mus musculus	0-7
32119943-4	2020	On that condition, the free formaldehyde content of the corresponding product HL-6 was as low as 0.32%, while the hydroxymethyl was increased by 189.11% compared with original AAL and reached 2.92 mmol/g.	Formaldehyde	28-40	transmembrane 4 L six family member 1	Homo sapiens	78-82
31796633-2	2020	METHODS: We evaluated the characteristics of HER2-positivity pattern in formalin-fixed paraffin-embedded samples using IHC and FISH in 15 patients enrolled in a larger prospective cohort study to survey a HER2-positive NSCLC.	Formaldehyde	72-80	erb-b2 receptor tyrosine kinase 2	Homo sapiens	45-49
32468256-3	2020	The aim of this study was to evaluate the versatility of the high-resolution melting analysis (HRMA) obtained by magnetic induction cycler (MIC) to monitor the BRCA2 status in formalin-fixed paraffin-embedded (FFPE) tissue samples of this patient and to compare the results obtained by NGTS.	Formaldehyde	176-184	BRCA2 DNA repair associated	Homo sapiens	160-165
32498288-3	2020	RUNX1 protein levels were analyzed using immunohistochemistry of formalin-fixed paraffin-embedded tissues from 409 NSCLC patients.	Formaldehyde	65-73	RUNX family transcription factor 1	Homo sapiens	0-5
32270179-7	2020	Notably, analyses of transcripts, extracted from formalin-fixed paraffin-embedded specimens, revealed higher expression of INTS9, vWF, MACC1, and ARMS2, and diminished expression of the CNTN5 genes in the insufficient group.	Formaldehyde	49-57	integrator complex subunit 9	Homo sapiens	123-128
32270179-7	2020	Notably, analyses of transcripts, extracted from formalin-fixed paraffin-embedded specimens, revealed higher expression of INTS9, vWF, MACC1, and ARMS2, and diminished expression of the CNTN5 genes in the insufficient group.	Formaldehyde	49-57	von Willebrand factor	Homo sapiens	130-133
32270179-7	2020	Notably, analyses of transcripts, extracted from formalin-fixed paraffin-embedded specimens, revealed higher expression of INTS9, vWF, MACC1, and ARMS2, and diminished expression of the CNTN5 genes in the insufficient group.	Formaldehyde	49-57	MET transcriptional regulator MACC1	Homo sapiens	135-140
32270179-7	2020	Notably, analyses of transcripts, extracted from formalin-fixed paraffin-embedded specimens, revealed higher expression of INTS9, vWF, MACC1, and ARMS2, and diminished expression of the CNTN5 genes in the insufficient group.	Formaldehyde	49-57	age-related maculopathy susceptibility 2	Homo sapiens	146-151
32335808-0	2020	TNFAIP1 Mediates Formaldehyde-Induced Neurotoxicity by Inhibiting the Akt/CREB Pathway in N2a Cells.	Formaldehyde	17-29	thymoma viral proto-oncogene 1	Mus musculus	70-73
32335808-0	2020	TNFAIP1 Mediates Formaldehyde-Induced Neurotoxicity by Inhibiting the Akt/CREB Pathway in N2a Cells.	Formaldehyde	17-29	cAMP responsive element binding protein 1	Mus musculus	74-78
32135147-0	2020	Intra-articular injection of 2-pyridylethylamine produces spinal NPY-mediated antinociception in the formalin-induced rat knee-joint pain model.	Formaldehyde	101-109	neuropeptide Y	Rattus norvegicus	65-68
32369366-6	2020	Moreover, it"s found that the syn-POZ can directly decompose to peroxyformic acid plus formaldehyde breaking the known "Criegee mechanism" to form carbonyl oxide with carbonyl compound.	Formaldehyde	87-99	synemin	Homo sapiens	30-33
33209194-8	2020	Moreover, chrysin caused a reduction of formalin-induced up-regulated spinal p-CREB level, which was also reversed by i.t.	Formaldehyde	40-48	cAMP responsive element binding protein 1	Mus musculus	79-83
33209194-12	2020	In addition, spinal opioid receptors and CREB protein appear to mediate chrysin-induced antinociception in the formalin-induced pain model.	Formaldehyde	111-119	cAMP responsive element binding protein 1	Mus musculus	41-45
32528273-2	2020	Recently, reports from our research team revealed that red light treatment (RLT) improved memory in AD mice by activating formaldehyde dehydrogenase (FDH) and thus reducing formaldehyde levels.	Formaldehyde	122-134	alcohol dehydrogenase 5 (class III), chi polypeptide	Mus musculus	150-153
32428030-5	2020	Immunohistochemical analysis of a comprehensive set of tissue microarrays comprising over 1,200 formalin-fixed, paraffin-embedded tissue cores from human epithelial tumors and inflammatory disease confirmed that NOX1 is overexpressed in human colon and small intestinal adenocarcinomas, as well as adenomatous polyps, compared to adjacent, uninvolved intestinal mucosae.	Formaldehyde	96-104	NADPH oxidase 1	Homo sapiens	212-216
32539923-3	2020	This study aimed to investigate the diagnostic value of miR-7-5p and miR-451 levels in formalin-fixed paraffin-embedded tissues of papillary thyroid carcinoma (PTC) patients, as well as the relationship between clinicopathological characteristics and the two miRNAs.	Formaldehyde	87-95	microRNA 7-3	Homo sapiens	56-64
32422543-12	2020	BRAF mutation analysis was primarily performed using the Cobas 4800 BRAF V600 Mutation Test (92.8%) on formalin-fixed, paraffin-embedded tissue (95.8%).	Formaldehyde	103-111	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	0-4
32536910-4	2020	Immunohistochemical expression and cellular localization of IDO2 was evaluated on 191 formalin-fixed and paraffin-embedded resected NSCLC.	Formaldehyde	86-94	indoleamine 2,3-dioxygenase 2	Homo sapiens	60-64
32466184-1	2020	We introduce a machine learning-based analysis to predict the immunohistochemical (IHC) labeling index for the cell proliferation marker Ki67/MIB1 on cancer tissues based on morphometrical features extracted from hematoxylin and eosin (H&E)-stained formalin-fixed, paraffin-embedded (FFPE) tumor tissue samples.	Formaldehyde	249-257	MIB E3 ubiquitin protein ligase 1	Homo sapiens	142-146
32458628-0	2020	Exploring Two Protocols of FISH Using Cytocell SYT-SSX Probe on Formalin Fixed Paraffin Embedded Tissue Sections.	Formaldehyde	64-72	synaptotagmin 1	Homo sapiens	47-50
32467727-8	2020	Increasing T-protein concentration can speed up the release rate of formaldehyde by Hint.	Formaldehyde	68-80	histidine triad nucleotide binding protein 1	Homo sapiens	84-88
32255634-7	2020	The main products (and associated relative abundances) originating from unimolecular decay of anti-MVK-oxide and subsequent reaction with O2 are formaldehyde (88 +- 5%), ketene (9 +- 1%) and glyoxal (3 +- 1%).	Formaldehyde	145-157	mevalonate kinase	Homo sapiens	99-102
32370743-2	2020	METHODS: We investigated the expression and localization of miR-18a and -18b in formalin fixed paraffin embedded (FFPE) tissue from lymph node negative breast cancers (n = 40), by chromogenic in situ hybridization (CISH).	Formaldehyde	80-88	microRNA 18a	Homo sapiens	60-76
32467727-7	2020	The reason is that T-protein of the GCS can degrade methylamine-loaded H-protein (Hint) to formaldehyde and ammonia, accompanied with the formation of dihydrolipoyl H-protein (Hred), but the reaction rate is less than 0.16% of that in the presence of THF.	Formaldehyde	91-103	myosin binding protein H	Homo sapiens	71-80
32467727-7	2020	The reason is that T-protein of the GCS can degrade methylamine-loaded H-protein (Hint) to formaldehyde and ammonia, accompanied with the formation of dihydrolipoyl H-protein (Hred), but the reaction rate is less than 0.16% of that in the presence of THF.	Formaldehyde	91-103	histidine triad nucleotide binding protein 1	Homo sapiens	82-86
30724750-7	2020	The ALK antigen demonstrated marked staining intensity differences across non-neutral buffered formalin fixative types and times.	Formaldehyde	95-103	ALK receptor tyrosine kinase	Homo sapiens	4-7
32151841-4	2020	H & E staining showed that in the 3.0 mg/m3 formaldehyde exposed group, the arrangement of pyramidal cells in CA1 area of mouse hippocampus was loose and disordered, the cell morphology was swollen and deformed, and the apical dendrites were shortened or even disappeared.	Formaldehyde	44-56	carbonic anhydrase 1	Mus musculus	110-113
31967664-8	2020	RT-qPCR confirmed that mRNA encoding CB1 and CB2 receptors was detectable in the ACC of formalin-injected rats, and unchanged in those expressing FCA.	Formaldehyde	88-96	cannabinoid receptor 1	Rattus norvegicus	37-40
31967664-8	2020	RT-qPCR confirmed that mRNA encoding CB1 and CB2 receptors was detectable in the ACC of formalin-injected rats, and unchanged in those expressing FCA.	Formaldehyde	88-96	cannabinoid receptor 2	Rattus norvegicus	45-48
31918089-1	2020	The photocatalytic degradation of gaseous formaldehyde using Ag/F/N/W-doped titanium dioxide was examined.	Formaldehyde	42-54	angiopoietin like 6	Homo sapiens	61-65
32172419-3	2020	And the 10 g L-1 of PEI modified AC (PAC-30) has the highest adsorption capacity of formaldehyde, reached to 650 mg g-1, with an increasing magnitude of 240% in comparison with that without modified AC.	Formaldehyde	84-96	L1 cell adhesion molecule	Homo sapiens	13-35
32202903-3	2020	Tissue expression in formalin-fixed tissue biopsies of 94 cases of OSCC and 30 adjacent normal tissues was analyzed by immunohistochemistry (IHC) using an antibody against SNCG.	Formaldehyde	21-29	synuclein gamma	Homo sapiens	172-176
32202907-5	2020	We first found that in formalin-fixed, paraffin-embedded (FFPE) malignant lung samples, 90% (28/31) had increased SHOX2 and/or PTGER4 promoter methylation as compared with their adjacent non-malignant samples.	Formaldehyde	23-31	short stature homeobox 2	Homo sapiens	114-119
32365531-3	2020	The levels of AR mRNA and protein in frozen, formalin-fixed, paraffin-embedded tissue samples from PTC and adjacent normal thyroid tissue were assessed by quantitative real-time polymerase chain reaction and immunohistochemical staining, respectively, and the relationships between AR expression and clinical features were analyzed.	Formaldehyde	45-53	androgen receptor	Homo sapiens	14-16
32432058-4	2020	Methods: TM immunoexpression was assessed in n=185 formalin-fixed paraffin-embedded (FFPE) bladder tissue cores from n=98 patients by IHC.	Formaldehyde	51-59	thrombomodulin	Homo sapiens	9-11
32294701-2	2020	DPP4 expression was measured in formalin-fixed paraffin-embedded specimens that were gathered from 327 HCC patients.	Formaldehyde	32-40	dipeptidyl peptidase 4	Homo sapiens	0-4
32313120-3	2020	Six miRNAs that are differentially expressed during gastric carcinogenesis were selected, and quantitative real-time PCR was performed in an independent training set (fresh non-tumor and tumor samples from 18 GC patients) and validation sets (set 1 with formalin-fixed paraffin-embedded non-tumor and tumor samples from 19 solitary GC and set 2 with 37 multiple GC patients).	Formaldehyde	254-262	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	243-248
32300146-6	2020	TNX deficiency also increased pain sensitivity to chemical stimuli and aggravated early inflammatory pain elicited by formalin.	Formaldehyde	118-126	tenascin XB	Mus musculus	0-3
31649039-0	2020	Justification of direct Sanger sequencing application for detection of KIT and PDGFRalpha gene mutations in formalin-fixed, paraffin-embedded samples from gastrointestinal stromal tumours.	Formaldehyde	108-116	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	71-74
31987711-0	2020	Effect of spinal angiotensin-converting enzyme 2 activation on the formalin-induced nociceptive response in mice.	Formaldehyde	67-75	angiotensin I converting enzyme (peptidyl-dipeptidase A) 2	Mus musculus	17-48
31987711-1	2020	We have previously demonstrated that the phosphorylation of p38 MAPK, through spinal AT1 receptor activation, is involved in formalin-induced nociception and follows accompanied by the increase in spinal angiotensin (Ang) II levels.	Formaldehyde	125-133	mitogen-activated protein kinase 14	Mus musculus	60-68
31987711-1	2020	We have previously demonstrated that the phosphorylation of p38 MAPK, through spinal AT1 receptor activation, is involved in formalin-induced nociception and follows accompanied by the increase in spinal angiotensin (Ang) II levels.	Formaldehyde	125-133	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	204-224
31987711-11	2020	Furthermore, DIZE and Ang (1-7) each inhibited the formalin-induced phosphorylation of p38 MAPK on the dorsal lumbar spinal cord.	Formaldehyde	51-59	angiogenin, ribonuclease, RNase A family, 5	Mus musculus	22-30
31987711-11	2020	Furthermore, DIZE and Ang (1-7) each inhibited the formalin-induced phosphorylation of p38 MAPK on the dorsal lumbar spinal cord.	Formaldehyde	51-59	mitogen-activated protein kinase 14	Mus musculus	87-95
31987711-14	2020	Our data show that the i.t.-administered DIZE attenuates the second phase of the formalin-induced nociception which is accompanied by the inhibition of p38 MAPK phosphorylation.	Formaldehyde	81-89	mitogen-activated protein kinase 14	Mus musculus	152-160
32245434-0	2020	Clinical performance evaluation of the Idylla  EGFR Mutation Test on formalin-fixed paraffin-embedded tissue of non-small cell lung cancer.	Formaldehyde	69-77	epidermal growth factor receptor	Homo sapiens	47-51
32245434-3	2020	The Idylla  EGFR Mutation Test is a simple, fast and reliable method designed for the detection of EGFR mutations from formalin-fixed paraffin-embedded samples.	Formaldehyde	119-127	epidermal growth factor receptor	Homo sapiens	12-16
32245434-3	2020	The Idylla  EGFR Mutation Test is a simple, fast and reliable method designed for the detection of EGFR mutations from formalin-fixed paraffin-embedded samples.	Formaldehyde	119-127	epidermal growth factor receptor	Homo sapiens	99-103
32245434-5	2020	METHODS: EGFR mutational status was determined on 132 archived formalin-fixed paraffin-embedded tissue sections with Idylla  technology.	Formaldehyde	63-71	epidermal growth factor receptor	Homo sapiens	9-13
31205070-3	2020	We investigated 6 antibodies that are commonly used for breast cancer subtyping in research studies with immunohistochemistry (ER, PR, HER2, CK5/6, EGFR, and Ki67) in formalin-fixed paraffin-embedded breast tissue microarrays consisting of 148 patients.	Formaldehyde	167-175	erb-b2 receptor tyrosine kinase 2	Homo sapiens	135-139
31205070-3	2020	We investigated 6 antibodies that are commonly used for breast cancer subtyping in research studies with immunohistochemistry (ER, PR, HER2, CK5/6, EGFR, and Ki67) in formalin-fixed paraffin-embedded breast tissue microarrays consisting of 148 patients.	Formaldehyde	167-175	keratin 5	Homo sapiens	141-146
32168026-8	2020	Pretreatment with KOR antagonist (norbinaltorphimine 10 mg/kg) and DOR antagonist (naltrindole 10 mg/kg) abolished the antinociceptive effects of MP1104 in the formalin test.	Formaldehyde	160-168	opioid receptor, kappa 1	Mus musculus	18-21
32168026-8	2020	Pretreatment with KOR antagonist (norbinaltorphimine 10 mg/kg) and DOR antagonist (naltrindole 10 mg/kg) abolished the antinociceptive effects of MP1104 in the formalin test.	Formaldehyde	160-168	opioid receptor, delta 1	Mus musculus	67-70
31812766-5	2020	Moreover, formaldehyde significantly potentiated the induction of death receptor-5, caspase 8/10, cleaved caspase 3/7/9, pro-apoptotic proteins (Bim, Bad and Bax), depolarization of MMP (mitochondrial membrane potential) and AIF (apoptosis-inducing factor) induced by acrolein, and synergistically decreased expressions of pro-survival proteins (Bcl-2 and Bcl-XL) and poly ADP-ribose polymerase.	Formaldehyde	10-22	TNF receptor superfamily member 10b	Homo sapiens	66-82
31812766-5	2020	Moreover, formaldehyde significantly potentiated the induction of death receptor-5, caspase 8/10, cleaved caspase 3/7/9, pro-apoptotic proteins (Bim, Bad and Bax), depolarization of MMP (mitochondrial membrane potential) and AIF (apoptosis-inducing factor) induced by acrolein, and synergistically decreased expressions of pro-survival proteins (Bcl-2 and Bcl-XL) and poly ADP-ribose polymerase.	Formaldehyde	10-22	caspase 8	Homo sapiens	84-96
31812766-5	2020	Moreover, formaldehyde significantly potentiated the induction of death receptor-5, caspase 8/10, cleaved caspase 3/7/9, pro-apoptotic proteins (Bim, Bad and Bax), depolarization of MMP (mitochondrial membrane potential) and AIF (apoptosis-inducing factor) induced by acrolein, and synergistically decreased expressions of pro-survival proteins (Bcl-2 and Bcl-XL) and poly ADP-ribose polymerase.	Formaldehyde	10-22	caspase 3	Homo sapiens	106-119
31812766-5	2020	Moreover, formaldehyde significantly potentiated the induction of death receptor-5, caspase 8/10, cleaved caspase 3/7/9, pro-apoptotic proteins (Bim, Bad and Bax), depolarization of MMP (mitochondrial membrane potential) and AIF (apoptosis-inducing factor) induced by acrolein, and synergistically decreased expressions of pro-survival proteins (Bcl-2 and Bcl-XL) and poly ADP-ribose polymerase.	Formaldehyde	10-22	BCL2 like 11	Homo sapiens	145-148
31812766-5	2020	Moreover, formaldehyde significantly potentiated the induction of death receptor-5, caspase 8/10, cleaved caspase 3/7/9, pro-apoptotic proteins (Bim, Bad and Bax), depolarization of MMP (mitochondrial membrane potential) and AIF (apoptosis-inducing factor) induced by acrolein, and synergistically decreased expressions of pro-survival proteins (Bcl-2 and Bcl-XL) and poly ADP-ribose polymerase.	Formaldehyde	10-22	BCL2 associated X, apoptosis regulator	Homo sapiens	158-161
31812766-5	2020	Moreover, formaldehyde significantly potentiated the induction of death receptor-5, caspase 8/10, cleaved caspase 3/7/9, pro-apoptotic proteins (Bim, Bad and Bax), depolarization of MMP (mitochondrial membrane potential) and AIF (apoptosis-inducing factor) induced by acrolein, and synergistically decreased expressions of pro-survival proteins (Bcl-2 and Bcl-XL) and poly ADP-ribose polymerase.	Formaldehyde	10-22	apoptosis inducing factor mitochondria associated 1	Homo sapiens	225-228
31812766-5	2020	Moreover, formaldehyde significantly potentiated the induction of death receptor-5, caspase 8/10, cleaved caspase 3/7/9, pro-apoptotic proteins (Bim, Bad and Bax), depolarization of MMP (mitochondrial membrane potential) and AIF (apoptosis-inducing factor) induced by acrolein, and synergistically decreased expressions of pro-survival proteins (Bcl-2 and Bcl-XL) and poly ADP-ribose polymerase.	Formaldehyde	10-22	apoptosis inducing factor mitochondria associated 1	Homo sapiens	230-255
31812766-5	2020	Moreover, formaldehyde significantly potentiated the induction of death receptor-5, caspase 8/10, cleaved caspase 3/7/9, pro-apoptotic proteins (Bim, Bad and Bax), depolarization of MMP (mitochondrial membrane potential) and AIF (apoptosis-inducing factor) induced by acrolein, and synergistically decreased expressions of pro-survival proteins (Bcl-2 and Bcl-XL) and poly ADP-ribose polymerase.	Formaldehyde	10-22	BCL2 apoptosis regulator	Homo sapiens	346-351
31812766-5	2020	Moreover, formaldehyde significantly potentiated the induction of death receptor-5, caspase 8/10, cleaved caspase 3/7/9, pro-apoptotic proteins (Bim, Bad and Bax), depolarization of MMP (mitochondrial membrane potential) and AIF (apoptosis-inducing factor) induced by acrolein, and synergistically decreased expressions of pro-survival proteins (Bcl-2 and Bcl-XL) and poly ADP-ribose polymerase.	Formaldehyde	10-22	BCL2 like 1	Homo sapiens	356-362
31812766-5	2020	Moreover, formaldehyde significantly potentiated the induction of death receptor-5, caspase 8/10, cleaved caspase 3/7/9, pro-apoptotic proteins (Bim, Bad and Bax), depolarization of MMP (mitochondrial membrane potential) and AIF (apoptosis-inducing factor) induced by acrolein, and synergistically decreased expressions of pro-survival proteins (Bcl-2 and Bcl-XL) and poly ADP-ribose polymerase.	Formaldehyde	10-22	poly(ADP-ribose) polymerase 1	Homo sapiens	368-394
32084513-3	2020	This result led us to decipher CatS resistance to major and representative CSE oxidants: hydrogen peroxide, formaldehyde, acrolein and peroxynitrite.	Formaldehyde	108-120	cathepsin S	Felis catus	31-35
32719261-6	2020	Subjects and Methods: This study was designed to identify immunohistochemically the expression of p53 and MDM2 gene using monoclonal antibody in 60 cases of formalin-fixed paraffin-embedded tissue blocks, of which 20 cases were of solid multicystic ameloblastoma (SMA), 20 cases were of odontogenic keratocyst (OKC), and 20 cases were of unicystic ameloblastoma (UA).	Formaldehyde	157-165	transformation related protein 53, pseudogene	Mus musculus	98-101
32719261-6	2020	Subjects and Methods: This study was designed to identify immunohistochemically the expression of p53 and MDM2 gene using monoclonal antibody in 60 cases of formalin-fixed paraffin-embedded tissue blocks, of which 20 cases were of solid multicystic ameloblastoma (SMA), 20 cases were of odontogenic keratocyst (OKC), and 20 cases were of unicystic ameloblastoma (UA).	Formaldehyde	157-165	transformed mouse 3T3 cell double minute 2	Mus musculus	106-110
31649039-0	2020	Justification of direct Sanger sequencing application for detection of KIT and PDGFRalpha gene mutations in formalin-fixed, paraffin-embedded samples from gastrointestinal stromal tumours.	Formaldehyde	108-116	platelet derived growth factor receptor alpha	Homo sapiens	79-89
31793101-3	2020	To discover proteins that impact psbA expression, we identified proteins that associate with maize psbA mRNA by (i) formaldehyde crosslinking of leaf tissue followed by antisense oligonucleotide affinity capture of psbA mRNA, and (ii) coimmunoprecipitation with HCF173, a psbA translational activator that is known to bind psbA mRNA.	Formaldehyde	116-128	photosystem II protein D1	Zea mays	99-103
32124385-6	2020	METHODS: Five BRCA1 variants affecting splicing were characterized from formalin-fixed, paraffin-embedded (FFPE) ovarian carcinoma tissues by next-generation sequencing (NGS).	Formaldehyde	72-80	BRCA1 DNA repair associated	Homo sapiens	14-19
32101384-6	2020	In behavioral studies using rat models, PKM-833 significantly attenuated formalin-induced pain responses (3 mg/kg) and improved mechanical allodynia in complete freund"s adjuvant (CFA)-induced inflammatory pain (0.3-3 mg/kg).	Formaldehyde	73-81	pyruvate kinase M1/2	Rattus norvegicus	40-43
31793101-3	2020	To discover proteins that impact psbA expression, we identified proteins that associate with maize psbA mRNA by (i) formaldehyde crosslinking of leaf tissue followed by antisense oligonucleotide affinity capture of psbA mRNA, and (ii) coimmunoprecipitation with HCF173, a psbA translational activator that is known to bind psbA mRNA.	Formaldehyde	116-128	photosystem II protein D1	Zea mays	99-103
31793101-3	2020	To discover proteins that impact psbA expression, we identified proteins that associate with maize psbA mRNA by (i) formaldehyde crosslinking of leaf tissue followed by antisense oligonucleotide affinity capture of psbA mRNA, and (ii) coimmunoprecipitation with HCF173, a psbA translational activator that is known to bind psbA mRNA.	Formaldehyde	116-128	photosystem II protein D1	Zea mays	99-103
31793101-3	2020	To discover proteins that impact psbA expression, we identified proteins that associate with maize psbA mRNA by (i) formaldehyde crosslinking of leaf tissue followed by antisense oligonucleotide affinity capture of psbA mRNA, and (ii) coimmunoprecipitation with HCF173, a psbA translational activator that is known to bind psbA mRNA.	Formaldehyde	116-128	photosystem II protein D1	Zea mays	99-103
32209475-5	2020	In vitro, hHR23A specifically demethylates H4K20me1/2/3 and generates formaldehyde.	Formaldehyde	70-82	RAD23 homolog A, nucleotide excision repair protein	Homo sapiens	10-16
32150626-4	2020	EGFR expression was assessed on the archival Formalin Fixed Paraffin Embedded (FFPE) blocks using immunohistochemical staining technique.	Formaldehyde	45-53	epidermal growth factor receptor	Homo sapiens	0-4
32096638-0	2020	Highly Selective and Sensitive Detection of Formaldehyde by beta12-Borophene/SnO2 Heterostructure: The Role of an External Electric Field and In-Plain Biaxial Strain.	Formaldehyde	44-56	strawberry notch homolog 2	Homo sapiens	77-80
32058685-0	2020	Vacancy-assisted selective detection of low-ppb formaldehyde in two-dimensional layered SnS2.	Formaldehyde	48-60	sodium voltage-gated channel alpha subunit 11	Homo sapiens	88-92
32058685-1	2020	Two-dimensional layered SnS2 film synthesized by thermal-CVD method is utilized for detecting formaldehyde (HCHO), which causes sick building syndrome.	Formaldehyde	94-106	sodium voltage-gated channel alpha subunit 11	Homo sapiens	24-28
31926126-14	2020	In addition, MOTS-c treatment significantly increased AMPKalpha phosphorylation level and suppressed formalin-induced extracellular signal-regulated kinase (ERK), c-Jun amino-terminal kinases (JNK), and P38 activation and c-fos expression in the mouse spinal cord.	Formaldehyde	101-109	mitogen-activated protein kinase 1	Mus musculus	118-155
31926126-14	2020	In addition, MOTS-c treatment significantly increased AMPKalpha phosphorylation level and suppressed formalin-induced extracellular signal-regulated kinase (ERK), c-Jun amino-terminal kinases (JNK), and P38 activation and c-fos expression in the mouse spinal cord.	Formaldehyde	101-109	mitogen-activated protein kinase 1	Mus musculus	157-160
31926126-14	2020	In addition, MOTS-c treatment significantly increased AMPKalpha phosphorylation level and suppressed formalin-induced extracellular signal-regulated kinase (ERK), c-Jun amino-terminal kinases (JNK), and P38 activation and c-fos expression in the mouse spinal cord.	Formaldehyde	101-109	mitogen-activated protein kinase 8	Mus musculus	163-191
31926126-14	2020	In addition, MOTS-c treatment significantly increased AMPKalpha phosphorylation level and suppressed formalin-induced extracellular signal-regulated kinase (ERK), c-Jun amino-terminal kinases (JNK), and P38 activation and c-fos expression in the mouse spinal cord.	Formaldehyde	101-109	mitogen-activated protein kinase 8	Mus musculus	193-196
31926126-14	2020	In addition, MOTS-c treatment significantly increased AMPKalpha phosphorylation level and suppressed formalin-induced extracellular signal-regulated kinase (ERK), c-Jun amino-terminal kinases (JNK), and P38 activation and c-fos expression in the mouse spinal cord.	Formaldehyde	101-109	mitogen-activated protein kinase 14	Mus musculus	203-206
31926126-14	2020	In addition, MOTS-c treatment significantly increased AMPKalpha phosphorylation level and suppressed formalin-induced extracellular signal-regulated kinase (ERK), c-Jun amino-terminal kinases (JNK), and P38 activation and c-fos expression in the mouse spinal cord.	Formaldehyde	101-109	FBJ osteosarcoma oncogene	Mus musculus	222-227
31919847-10	2020	TRESK is also involved in osmotic pain and in early phases of formalin-induced inflammatory pain, but not in the development of mechanical and heat hyperalgesia during chronic pain.	Formaldehyde	62-70	potassium channel, subfamily K, member 18	Mus musculus	0-5
32564736-4	2020	Only native ArdB, but not the ArdBDeltaD141 mutant lacking the antirestriction activity, co-purified with DNA upon anion-exchange and affinity chromatography or total DNA isolation from formaldehyde-treated cells.	Formaldehyde	186-198	ArdB	Escherichia coli	12-16
31616036-0	2020	The complexity of screening PMS2 in DNA isolated from formalin-fixed paraffin-embedded material.	Formaldehyde	54-62	PMS1 homolog 2, mismatch repair system component	Homo sapiens	28-32
32158967-7	2020	After the exclusion of two cases because of tissue sparsity, BAP-1 immunohistochemical expression was evaluated in 68 cases of formalin-fixed, paraffin-embedded TMA tissue blocks.	Formaldehyde	127-135	BRCA1 associated protein 1	Homo sapiens	61-66
31718931-5	2020	METHODS: The gene expression of TLR4 (through real-time PCR) and TLR4 and SP-A positive cells and alveolar type II cells, as SP-A producers, (using IHC) were assessed in formalin fixed paraffin embedded (FFPE) specimens from SM-exposed (n = 17), and non-SM exposed individuals (n = 12).	Formaldehyde	170-178	toll like receptor 4	Homo sapiens	32-36
31981011-3	2020	In this work, we contrast and analyze the endogenous fluorescence from tryptophan, vitamin A, hydroxyproline and elastin cross-links potential biomarkers of the liver fibrosis, in in vivo measurements and liver samples preserved on formaldehyde, and two standard preservation media.	Formaldehyde	232-244	elastin	Homo sapiens	113-120
31891442-4	2020	Trop-2 expression was assessed in 143 formalin-fixed-paraffin-embedded tumors and seven primary tumor cell lines by immunohistochemistry and flow cytometry, respectively.	Formaldehyde	38-46	tumor associated calcium signal transducer 2	Homo sapiens	0-6
31842702-5	2020	In addition, it indicates that Olig2 is a useful marker to confirm glial lineage in formalin-fixed, paraffin-embedded bovine tissue.	Formaldehyde	84-92	oligodendrocyte transcription factor 2	Bos taurus	31-36
31758947-4	2020	In the current study, we found that pretreatment with the JNK inhibitor SP600125 (3 mg/kg) attenuates tolerance to the antinociceptive in the formalin test and to the anti-allodynic effects of Delta9-THC (6 mg/kg) in cisplatin-evoked neuropathic pain using wild-type mice.	Formaldehyde	142-150	mitogen-activated protein kinase 8	Mus musculus	58-61
32063193-0	2020	Alpha-1 antitrypsin inhibits formaldehyde-induced apoptosis of human peritoneal mesothelial cells.	Formaldehyde	29-41	serpin family A member 1	Homo sapiens	0-19
32063193-4	2020	This study aimed to evaluate the effect of AAT on formaldehyde-induced apoptosis of human peritoneal mesothelial cells (HPMCs).	Formaldehyde	50-62	serpin family A member 1	Homo sapiens	43-46
32063193-11	2020	Compared with the control, caspase-3 activity was significantly increased and the ratio of Bcl-2 to Bad expression significantly decreased following treatment with formaldehyde.	Formaldehyde	164-176	caspase 3	Homo sapiens	27-36
32063193-11	2020	Compared with the control, caspase-3 activity was significantly increased and the ratio of Bcl-2 to Bad expression significantly decreased following treatment with formaldehyde.	Formaldehyde	164-176	BCL2 apoptosis regulator	Homo sapiens	91-96
32063193-12	2020	However, caspase-3 activity was significantly lower and the Bcl-2 to Bad expression ratio higher in the AAT group than in the formaldehyde-only group.	Formaldehyde	126-138	serpin family A member 1	Homo sapiens	104-107
32063193-13	2020	CONCLUSION: AAT inhibits formaldehyde-induced apoptosis of HPMCs via a caspase-mediated pathway.	Formaldehyde	25-37	serpin family A member 1	Homo sapiens	12-15
31863585-0	2020	Adapted formaldehyde gradient cross-linking protocol implicates human eIF3d and eIF3c, k and l subunits in the 43S and 48S pre-initiation complex assembly, respectively.	Formaldehyde	8-20	eukaryotic translation initiation factor 3 subunit D	Homo sapiens	70-75
31863585-0	2020	Adapted formaldehyde gradient cross-linking protocol implicates human eIF3d and eIF3c, k and l subunits in the 43S and 48S pre-initiation complex assembly, respectively.	Formaldehyde	8-20	eukaryotic translation initiation factor 3 subunit C	Homo sapiens	80-85
31891736-0	2020	NADPH oxidase1 inhibition leads to regression of central sensitization during formalin induced acute nociception via attenuation of ERK1/2-NFkappaB signaling and glial activation.	Formaldehyde	78-86	NADPH oxidase 1	Mus musculus	0-14
31891736-0	2020	NADPH oxidase1 inhibition leads to regression of central sensitization during formalin induced acute nociception via attenuation of ERK1/2-NFkappaB signaling and glial activation.	Formaldehyde	78-86	mitogen-activated protein kinase 3	Mus musculus	132-138
31891736-0	2020	NADPH oxidase1 inhibition leads to regression of central sensitization during formalin induced acute nociception via attenuation of ERK1/2-NFkappaB signaling and glial activation.	Formaldehyde	78-86	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	139-147
31976646-4	2020	Three different biopolymer shell coatings were compared (formaldehyde-treated serum albumin (FSA), gelatin, heparin).	Formaldehyde	57-69	albumin	Homo sapiens	78-91
32059046-6	2020	This study aimed to investigate c-erbB2 mRNA expression in retrospective formalin-fixed paraffin embedded samples, using RNA in situ hybridization with a novel quantitative assay and to compare this method with immunohistochemistry.	Formaldehyde	73-81	erb-b2 receptor tyrosine kinase 2	Canis lupus familiaris	32-39
32102354-8	2020	In conclusion, pharmacological blockade of PPARalpha and PPARbeta/delta in the presence of formalin-evoked nociceptive tone, impaired short-term, within-trial fear-extinction in rats without affecting pain response, while blockade of PPARgamma potentiated conditioned fear responding.	Formaldehyde	91-99	peroxisome proliferator activated receptor alpha	Rattus norvegicus	43-52
32102354-8	2020	In conclusion, pharmacological blockade of PPARalpha and PPARbeta/delta in the presence of formalin-evoked nociceptive tone, impaired short-term, within-trial fear-extinction in rats without affecting pain response, while blockade of PPARgamma potentiated conditioned fear responding.	Formaldehyde	91-99	peroxisome proliferator activated receptor alpha	Rattus norvegicus	57-71
32110671-5	2020	Next-generation sequencing on formalin fixed paraffin-embedded (FFPE) tissue was also performed and suggested HER2 gene amplification in the FFPE tissue.	Formaldehyde	30-38	erb-b2 receptor tyrosine kinase 2	Homo sapiens	110-114
32117765-4	2020	Methods: Trop-2 expression was assessed in 90 formalin-fixed-paraffin-embedded tumors and nine primary tumor cell lines by immunohistochemistry (IHC) and flow cytometry, respectively.	Formaldehyde	46-54	tumor associated calcium signal transducer 2	Homo sapiens	9-15
32012175-9	2020	AIRE coprecipitated with ETS1 in a modified immunoprecipitation assay using formaldehyde crosslinking.	Formaldehyde	76-88	autoimmune regulator	Homo sapiens	0-4
32033262-5	2020	Expression of the adhesion integrin alpha7 (ITGA7) was significantly higher in the GS group, as seen by RT-qPCR (p = 0.00188) and immunohistochemistry of bone marrow formalin-fixed, paraffin-embedded (FFPE) specimens.	Formaldehyde	166-174	integrin subunit alpha 7	Homo sapiens	27-42
32033262-5	2020	Expression of the adhesion integrin alpha7 (ITGA7) was significantly higher in the GS group, as seen by RT-qPCR (p = 0.00188) and immunohistochemistry of bone marrow formalin-fixed, paraffin-embedded (FFPE) specimens.	Formaldehyde	166-174	integrin subunit alpha 7	Homo sapiens	44-49
32082489-4	2020	Methods: Trop-2 expression was evaluated in 10 formalin-fixed-paraffined-embedded (FFPE) CS by immunohistochemistry and 9 primary CS cell-lines by flow-cytometry.	Formaldehyde	47-55	tumor associated calcium signal transducer 2	Homo sapiens	9-15
32012175-9	2020	AIRE coprecipitated with ETS1 in a modified immunoprecipitation assay using formaldehyde crosslinking.	Formaldehyde	76-88	ETS proto-oncogene 1, transcription factor	Homo sapiens	25-29
31816758-5	2020	Their limit of formaldehyde detection was as low as 8 ppb in dry air and 50 ppb in air with 60% RH at 25  C. These results were much better that those reported in the open literature and they were attributed to both higher area BET, around 180 m2/g, and smaller crystallite size, 3.1 nm.	Formaldehyde	15-27	delta/notch like EGF repeat containing	Homo sapiens	228-231
31843498-2	2020	In this study we investigated the activation of Src family kinase (SFK) and two SFK substrates-CUB-domain containing protein 1 (CDCP1) and protein kinase C delta (PKCdelta)-in 56 formalin-fixed, paraffin embedded (FFPE) TNBC.	Formaldehyde	179-187	CUB domain containing protein 1	Homo sapiens	95-126
31843498-2	2020	In this study we investigated the activation of Src family kinase (SFK) and two SFK substrates-CUB-domain containing protein 1 (CDCP1) and protein kinase C delta (PKCdelta)-in 56 formalin-fixed, paraffin embedded (FFPE) TNBC.	Formaldehyde	179-187	CUB domain containing protein 1	Homo sapiens	128-133
31843498-2	2020	In this study we investigated the activation of Src family kinase (SFK) and two SFK substrates-CUB-domain containing protein 1 (CDCP1) and protein kinase C delta (PKCdelta)-in 56 formalin-fixed, paraffin embedded (FFPE) TNBC.	Formaldehyde	179-187	protein kinase C delta	Homo sapiens	139-161
31843498-2	2020	In this study we investigated the activation of Src family kinase (SFK) and two SFK substrates-CUB-domain containing protein 1 (CDCP1) and protein kinase C delta (PKCdelta)-in 56 formalin-fixed, paraffin embedded (FFPE) TNBC.	Formaldehyde	179-187	protein kinase C delta	Homo sapiens	163-171
31792349-3	2020	METHODS: We developed Time Resolved-Forster Resonance Energy Transfer (TR-FRET) assays to quantify HER1, HER2 and HER3 in formalin-fixed paraffin-embedded (FFPE) tumour tissues.	Formaldehyde	122-130	epidermal growth factor receptor	Homo sapiens	99-103
31792349-3	2020	METHODS: We developed Time Resolved-Forster Resonance Energy Transfer (TR-FRET) assays to quantify HER1, HER2 and HER3 in formalin-fixed paraffin-embedded (FFPE) tumour tissues.	Formaldehyde	122-130	erb-b2 receptor tyrosine kinase 3	Homo sapiens	114-118
31902597-0	2020	Expressions of spinal microglia activation, BDNF, and DREAM proteins correlated with formalin-induced nociceptive responses in painful and painless diabetic neuropathy rats.	Formaldehyde	85-93	brain-derived neurotrophic factor	Rattus norvegicus	44-48
31902597-0	2020	Expressions of spinal microglia activation, BDNF, and DREAM proteins correlated with formalin-induced nociceptive responses in painful and painless diabetic neuropathy rats.	Formaldehyde	85-93	potassium voltage-gated channel interacting protein 3	Rattus norvegicus	54-59
32362707-9	2020	Our study suggests while GAN is able to attain formalin fixed and paraffin embedded tissue image quality, GAN requires further prior knowledge as input to model intrinsic micro-anatomical details, such as capillary wall, urinary pole, nuclei placement, suggesting developing semi-supervised architectures by using these above details as prior information.	Formaldehyde	47-55	gigaxonin	Homo sapiens	25-28
31823256-5	2020	In A549 cell lines, formaldehyde treatment significantly decreased cell viability, glutathione level, and enzyme activities of superoxide dismutase and catalase; however, malondialdehyde levels of the cell lysate were found to increase compared with the control group.	Formaldehyde	20-32	catalase	Homo sapiens	152-160
31557339-2	2020	METHODS AND RESULTS: A retrospective review of the Mayo Clinic cytogenetic database identified 470 patients evaluated by FISH testing for TP63 rearrangements in formalin-fixed paraffin-embedded (FFPE) tissue using both BAP and D-FISH probes.	Formaldehyde	161-169	tumor protein p63	Homo sapiens	138-142
32099398-2	2020	Patients and Methods: For the detection of the correlation between GATA3 expression and bladder cancer, we downloaded the mRNA expression data from the Cancer Genome Atlas (TCGA) database and conducted immunohistochemistry staining on formalin-fixed paraffin-embedded (FFPE) sample tissues.	Formaldehyde	235-243	GATA binding protein 3	Homo sapiens	67-72
31843462-2	2020	Selective for COX-2 over COX-1, compound 10 exhibited IC50 0.02 microM for COX-2 and reversed acetic acid induced inflammation in rats by 73% when used at 10 mg kg-1 dose and the same dose of the compound also rescued the animals from inflammatory phase of formalin induced hyperalgesia.	Formaldehyde	257-265	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	14-19
31995761-5	2020	We validate the ARK assay with genetic mutants with established deficiencies in DPC repair and demonstrate its robustness by using common DPC-inducing reagents, including formaldehyde, camptothecin, and etoposide.	Formaldehyde	171-183	AXL receptor tyrosine kinase	Homo sapiens	16-19
31968239-0	2020	Loss of bhlha9 Impairs Thermotaxis and Formalin-Evoked Pain in a Sexually Dimorphic Manner.	Formaldehyde	39-47	basic helix-loop-helix family, member a9	Mus musculus	8-14
31968239-3	2020	Here, we report that deletion of C-low-threshold mechanoreceptor (C-LTMR)-expressed bhlha9 causes impaired thermotaxis behavior and exacerbated formalin-evoked pain in male, but not female, mice.	Formaldehyde	144-152	basic helix-loop-helix family, member a9	Mus musculus	84-90
32025485-2	2020	For NSCLC patients, EGFR mutation testing is performed using the commercial Cobas EGFR Mutation test v2.0, which can be used to analyze both formalin-fixed, paraffin-embedded (FFPE) tissue (FFPE test, or FT) and plasma samples (plasma test, or PT).	Formaldehyde	141-149	epidermal growth factor receptor	Homo sapiens	20-24
31843462-2	2020	Selective for COX-2 over COX-1, compound 10 exhibited IC50 0.02 microM for COX-2 and reversed acetic acid induced inflammation in rats by 73% when used at 10 mg kg-1 dose and the same dose of the compound also rescued the animals from inflammatory phase of formalin induced hyperalgesia.	Formaldehyde	257-265	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	25-30
31163960-1	2020	Purpose: The aim of this study was to develop a formalin-fixed paraffin-embedded (FFPE) tissue based multiplex immunochemistry (mIHC) method for high-throughput comprehensive tissue imaging and demonstrate its feasibility, validity, and usefulness.	Formaldehyde	48-56	myosin IA	Mus musculus	128-132
31936554-5	2020	The effective amount of chemical admixtures for spun concrete is 0.15% of cement mass when formaldehyde resin ACF-3M and 1% of cement mass when superplasticizers C-3 and "Dofen" are used.	Formaldehyde	91-103	bromodomain adjacent to zinc finger domain 1A	Homo sapiens	110-122
33350988-6	2020	Additionally, p-CREB and p-ERK levels in the spinal cord and the adrenal gland increased after formalin injection.	Formaldehyde	95-103	mitogen-activated protein kinase 1	Mus musculus	27-30
33350988-7	2020	Pretreatment with beta-amyloid attenuated formalin-induced overexpression of p-CREB and p-ERK in the spinal cord and the adrenal gland.	Formaldehyde	42-50	cAMP responsive element binding protein 1	Mus musculus	79-83
33350988-7	2020	Pretreatment with beta-amyloid attenuated formalin-induced overexpression of p-CREB and p-ERK in the spinal cord and the adrenal gland.	Formaldehyde	42-50	mitogen-activated protein kinase 1	Mus musculus	90-93
33350988-9	2020	Furthermore, the reduction of nociception by beta-amyloid in the formalin pain model appears to be mediated, at least in part, by the suppression of p-CREB and p-ERK level in the spinal cord and the adrenal gland.	Formaldehyde	65-73	cAMP responsive element binding protein 1	Mus musculus	151-155
33350988-9	2020	Furthermore, the reduction of nociception by beta-amyloid in the formalin pain model appears to be mediated, at least in part, by the suppression of p-CREB and p-ERK level in the spinal cord and the adrenal gland.	Formaldehyde	65-73	mitogen-activated protein kinase 1	Mus musculus	162-165
30095463-2	2020	Our aim was to test a novel in situ hybridization technique, RNAscope, for the detection of human telomerase reverse transcriptase (hTERT) mRNA in archival formalin-fixed, paraffin-embedded (FFPE) tissue and to compare the mRNA expression of melanomas and benign naevi.	Formaldehyde	156-164	telomerase reverse transcriptase	Homo sapiens	98-130
30095463-2	2020	Our aim was to test a novel in situ hybridization technique, RNAscope, for the detection of human telomerase reverse transcriptase (hTERT) mRNA in archival formalin-fixed, paraffin-embedded (FFPE) tissue and to compare the mRNA expression of melanomas and benign naevi.	Formaldehyde	156-164	telomerase reverse transcriptase	Homo sapiens	132-137
31668840-4	2020	A maximum ion-exchange capacity of 2.26 mmol/g was achieved for the LBR obtained at 120  C for 4 h with a molar ratio of phenol to formaldehyde (P:F) of 1:5 (SSPL-0.50), which was comparable to the commercial phenol type cation exchange resin.	Formaldehyde	131-143	lamin B receptor	Homo sapiens	68-71
31931827-7	2020	The patient"s formalin-fixed paraffin-embedded tumor biopsy specimen underwent multiple-gene testing by next-generation sequencing, which identified a FANCA homodeletion.	Formaldehyde	14-22	FA complementation group A	Homo sapiens	151-156
31845583-2	2020	Herein, a novel formaldehyde (HCHO) responsive ionic microchannel was successfully fabricated through constructing ethylenediamine (EDA) functionalized poly (ionic liquid)/polyacrylonitrile nanofibrous membrane (PIL/PAN NFM).	Formaldehyde	16-28	serpin family A member 2 (gene/pseudogene)	Homo sapiens	212-215
33350988-6	2020	Additionally, p-CREB and p-ERK levels in the spinal cord and the adrenal gland increased after formalin injection.	Formaldehyde	95-103	cAMP responsive element binding protein 1	Mus musculus	16-20
31049933-5	2020	Formalin-fixed paraffin-embedded tissues were used for histological review and to measure the expression by immunohistochemistry of surrogate markers of activation of the TCR-PLCG1-NFAT, JAK-STAT and NF-kappaB pathways.	Formaldehyde	0-8	phospholipase C gamma 1	Homo sapiens	175-180
31017233-11	2020	The Sc-Hex at all doses tested was effective in reducing the nociceptive behavior produced by formalin only in the second phase.	Formaldehyde	94-102	hematopoietically expressed homeobox	Mus musculus	7-10
31662264-0	2020	Exposure to both formaldehyde and high relative humidity exacerbates allergic asthma by activating the TRPV4-p38 MAPK pathway in Balb/c mice.	Formaldehyde	17-29	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	103-108
31662264-10	2020	Blocking TRPV4or p38 MAPK using HC-067047 and SB203580 respectively, effectively alleviated the exacerbation of allergic asthma induced by this simultaneous exposure to formaldehyde and high relative humidity.	Formaldehyde	169-181	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	9-14
31662264-0	2020	Exposure to both formaldehyde and high relative humidity exacerbates allergic asthma by activating the TRPV4-p38 MAPK pathway in Balb/c mice.	Formaldehyde	17-29	mitogen-activated protein kinase 14	Mus musculus	109-117
31662264-10	2020	Blocking TRPV4or p38 MAPK using HC-067047 and SB203580 respectively, effectively alleviated the exacerbation of allergic asthma induced by this simultaneous exposure to formaldehyde and high relative humidity.	Formaldehyde	169-181	mitogen-activated protein kinase 14	Mus musculus	17-25
31077320-6	2020	Molecular consequences of hnRNP K overexpression were determined through proteomics, formaldehyde-RNA-immunoprecipitation sequencing, and biochemical assays.	Formaldehyde	85-97	heterogeneous nuclear ribonucleoprotein K	Mus musculus	26-33
31662264-11	2020	The results show that when formaldehyde and high relative humidity are present this can enhance the activation of the TRPV4 ion channel in the lung leading to the aggravation of the p38 MAPK activation, resulting in the exacerbation of inflammation and hypersecretion of mucus in the airways.	Formaldehyde	27-39	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	118-123
31662264-11	2020	The results show that when formaldehyde and high relative humidity are present this can enhance the activation of the TRPV4 ion channel in the lung leading to the aggravation of the p38 MAPK activation, resulting in the exacerbation of inflammation and hypersecretion of mucus in the airways.	Formaldehyde	27-39	mitogen-activated protein kinase 14	Mus musculus	182-190
31605792-6	2020	RESULTS: PD-L1 staining was successful in 193 of 197 patient formalin-fixed paraffin-embedded blocks; of these, 128 of 193 were EGFRm-positive and 106 of 128 patients were randomized to treatment (osimertinib: 54; comparator: 52).	Formaldehyde	61-69	CD274 molecule	Homo sapiens	9-14
31641223-11	2020	In a blinded study, we detected ALK fusion from formalin-fixed paraffin-embedded lung cancer samples with a 100% 47) and genotyping /47) and genotyping (7/7).	Formaldehyde	48-56	ALK receptor tyrosine kinase	Homo sapiens	32-35
31309518-1	2020	The application of immunohistological methods provides an invaluable contribution in revealing the protein colocalization, which may reflect the occurrence of molecular interaction processes.This chapter describes comprehensive protocols for detection of S100A7/JAB1 colocalization by immunohistochemistry in archival formalin-fixed and paraffin-embedded skin biopsies from healthy and psoriatic subjects.	Formaldehyde	318-326	S100 calcium binding protein A7	Homo sapiens	255-261
31745876-0	2020	Concurrent Immunohistochemical Localization and Western Blot Analysis of the MIF Receptor, CD74, in Formalin-Fixed, Paraffin-Embedded Tissue.	Formaldehyde	100-108	macrophage migration inhibitory factor	Homo sapiens	77-80
31550727-0	2020	Hydrogen Sulfide Ameliorates Cognitive Dysfunction in Formaldehyde-Exposed Rats: Involvement in the Upregulation of Brain-Derived Neurotrophic Factor.	Formaldehyde	54-66	brain-derived neurotrophic factor	Rattus norvegicus	116-149
31745876-0	2020	Concurrent Immunohistochemical Localization and Western Blot Analysis of the MIF Receptor, CD74, in Formalin-Fixed, Paraffin-Embedded Tissue.	Formaldehyde	100-108	CD74 molecule	Homo sapiens	91-95
33121353-9	2020	The formalin-induced c-Fos expression at the spinal cord level was not affected by fasting, and in vivo recording from the superficial dorsal horn of the lumbar spinal cord revealed that fasting did not affect formalin-induced neural activity, which indicates minimal involvement of the spinal cord in fasting-induced analgesia.	Formaldehyde	4-12	FBJ osteosarcoma oncogene	Mus musculus	21-26
31939170-2	2020	The described protocol has been optimized for IL-1 detection in formalin-fixed, paraffin-embedded oral tissue sections by light microscopy.	Formaldehyde	64-72	interleukin 1 alpha	Homo sapiens	46-50
31718146-5	2019	Additionally, results demonstrated that the inflammatory responses of cells stimulated by gas pollution (formaldehyde (FA) and benzene (Ben) as models) from gas phase were more obvious than those induced by gas pollution from solution, especially the increment of interleukin-2 (IL-2), IL-6 and tumor necrosis factor alpha (TNF-alpha) was almost 2 times larger than that induced by gas pollution from solution.	Formaldehyde	105-117	interleukin 2	Homo sapiens	264-277
31846974-4	2020	The expression of c-Met was determined by immunohistochemistry using archived formalin-fixed paraffin-embedded samples.	Formaldehyde	78-86	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	18-23
31890056-0	2019	Acid-specific formaldehyde donor is a potential, dual targeting cancer chemotherapeutic/chemo preventive drug for FANC/BRCA-mutant cancer.	Formaldehyde	14-26	BRCA1 DNA repair associated	Homo sapiens	119-123
31890056-6	2019	We previously reported that both a chicken B-lymphocyte cell line transformed with an avian leucosis virus and human colon cancer cells deficient in the FANC/BRCA pathway are hypersensitive to formaldehyde.	Formaldehyde	193-205	BRCA1 DNA repair associated	Homo sapiens	158-162
31859115-0	2020	Comparison detection methods for EGFR in formalin-fixed paraffin-embedded tissues of patients with NSCLC.	Formaldehyde	41-49	epidermal growth factor receptor	Homo sapiens	33-37
31882696-6	2019	The nonsynonymous mutation for KMT2B p.Ile2602Val identified in the formalin-fixed paraffin-embedded tumor sample was also confirmed in the CSC.	Formaldehyde	68-76	lysine methyltransferase 2B	Homo sapiens	31-36
31098781-0	2019	ASO Author Reflections: Precise p53 Analysis in Formalin-Fixed Paraffin-Embedded Specimens Can Predict Head and Neck Squamous Cell Carcinoma Outcomes.	Formaldehyde	48-56	tumor protein p53	Homo sapiens	32-35
31856055-5	2019	The experiment was to detect MYH7 gene status in formalin-fixed paraffin-embedded tissues from 18 independent autopsy cases who suffered HCM related sudden death (fatal HCM) and 20 cases without cardiomyopathy.	Formaldehyde	49-57	myosin heavy chain 7	Homo sapiens	29-33
31805115-7	2019	Significant increase of c-Fos-IR cells in the Vc was found in 6-OHDA-injected rats after formalin administration compared with those in saline-injected rats after formalin administration.	Formaldehyde	89-97	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	24-29
31805115-7	2019	Significant increase of c-Fos-IR cells in the Vc was found in 6-OHDA-injected rats after formalin administration compared with those in saline-injected rats after formalin administration.	Formaldehyde	163-171	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	24-29
31172816-0	2019	Formaldehyde inhibits proliferation of bronchial epithelial cells by down-regulating miR-375.	Formaldehyde	0-12	microRNA 375	Homo sapiens	85-92
31172816-5	2019	Overexpression of miR-375 and KLF4 knockdown could reverse the inhibition effect of formaldehyde on proliferation of 16HBE cells; KLF4 is a target of miR-375.	Formaldehyde	84-96	microRNA 375	Homo sapiens	18-25
31172816-5	2019	Overexpression of miR-375 and KLF4 knockdown could reverse the inhibition effect of formaldehyde on proliferation of 16HBE cells; KLF4 is a target of miR-375.	Formaldehyde	84-96	Kruppel like factor 4	Homo sapiens	30-34
31172816-5	2019	Overexpression of miR-375 and KLF4 knockdown could reverse the inhibition effect of formaldehyde on proliferation of 16HBE cells; KLF4 is a target of miR-375.	Formaldehyde	84-96	Kruppel like factor 4	Homo sapiens	130-134
31172816-5	2019	Overexpression of miR-375 and KLF4 knockdown could reverse the inhibition effect of formaldehyde on proliferation of 16HBE cells; KLF4 is a target of miR-375.	Formaldehyde	84-96	microRNA 375	Homo sapiens	150-157
31172816-6	2019	KLF4 could reverse the promotion of miR-375 on the proliferation of formaldehyde-treated 16HBE cells.	Formaldehyde	68-80	Kruppel like factor 4	Homo sapiens	0-4
31172816-6	2019	KLF4 could reverse the promotion of miR-375 on the proliferation of formaldehyde-treated 16HBE cells.	Formaldehyde	68-80	microRNA 375	Homo sapiens	36-43
31651105-8	2019	CONCLUSION: Our findings assessed the implementation of RNA-sequencing approaches to explore ALK and ROS1 rearrangements from formalin-fixed paraffin-embedded samples.	Formaldehyde	126-134	ALK receptor tyrosine kinase	Homo sapiens	93-96
31651105-8	2019	CONCLUSION: Our findings assessed the implementation of RNA-sequencing approaches to explore ALK and ROS1 rearrangements from formalin-fixed paraffin-embedded samples.	Formaldehyde	126-134	ROS proto-oncogene 1, receptor tyrosine kinase	Homo sapiens	101-105
31600033-12	2019	The percentage of p16-positive cells was significantly higher with FFCB than with CCB (formalin: 94% +- 2%; CytoLyt, 38% +- 7%; 2-tailed, paired Student t test; P < .001; Fisher exact test, P < .001).	Formaldehyde	87-95	cyclin dependent kinase inhibitor 2A	Homo sapiens	18-21
31658426-2	2019	In this study, multiplexed immunohistochemistry was applied to stain CD103 and the T-cell marker CD8 as well as the DC marker CD11c on formalin-fixed, paraffin-embedded oral squamous cell carcinoma (OSCC) tissues.	Formaldehyde	135-143	integrin subunit alpha X	Homo sapiens	126-131
31377937-3	2019	Therefore, the study aims to detect the expression and localization of ATM protein and its association with clinicopathological parameters METHODS: Expression of nuclear ATM (nATM) was investigated on 69 formalin fixed paraffin embedded choroidal melanoma samples by immunohistochemistry and validated by western blotting.	Formaldehyde	204-212	ATM serine/threonine kinase	Homo sapiens	170-173
31612319-3	2019	METHOD: Expression of NC-NFkappaB proteins (p52, RelB, and co-expression of p52/RelB) was evaluated in 75 formalin-fixed cases of uveal melanoma by immunohistochemistry.	Formaldehyde	106-114	nuclear factor kappa B subunit 1	Homo sapiens	22-33
30685495-9	2019	To confirm pain-dependent Mn enhancement in the spinal cord, c-Fos expression was analyzed, and was found to be increased in the formalin-injected rats.	Formaldehyde	129-137	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	61-66
31609157-2	2019	We used commercial polyclonal and monoclonal antibodies and characterized three chromogenic cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) assays with suitable specificity and sensitivity for use in formalin-fixed, paraffin-embedded (FFPE) tissues.	Formaldehyde	205-213	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	137-143
31638234-0	2019	Development of recurrence risk score using 95-gene classifier and its application to formalin-fixed paraffin-embedded tissues in ER-positive, HER2-negative and node-negative breast cancer.	Formaldehyde	85-93	epiregulin	Homo sapiens	129-131
31638234-0	2019	Development of recurrence risk score using 95-gene classifier and its application to formalin-fixed paraffin-embedded tissues in ER-positive, HER2-negative and node-negative breast cancer.	Formaldehyde	85-93	erb-b2 receptor tyrosine kinase 2	Homo sapiens	142-146
31727501-5	2019	The expression pattern of SPARC and vascular endothelial growth factor (VEGF) (angiogenic factors) was evaluated by immunohistochemistry on formalin fixed paraffin embedded tissues.	Formaldehyde	140-148	vascular endothelial growth factor A	Homo sapiens	72-76
31805689-9	2019	Syb-prII-1 markedly suppressed the expression of IL-1beta, IL-6, and TNF-alpha of mice in formalin-induced inflammatory nociception.	Formaldehyde	90-98	interleukin 1 beta	Mus musculus	49-57
31614172-0	2019	Formaldehyde inhibits UV-induced phosphorylation of histone H2AX.	Formaldehyde	0-12	H2A.X variant histone	Homo sapiens	52-64
31805689-9	2019	Syb-prII-1 markedly suppressed the expression of IL-1beta, IL-6, and TNF-alpha of mice in formalin-induced inflammatory nociception.	Formaldehyde	90-98	tumor necrosis factor	Mus musculus	69-78
31690341-7	2019	The prognostic role was determined by correlating pY705-Stat3 expression on formalin-fixed paraffin-embedded tumour tissues with the patient"s survival in univariate and multivariate COX regressions.	Formaldehyde	76-84	signal transducer and activator of transcription 3	Homo sapiens	56-61
31711486-8	2019	RESULTS: In 50 formalin-fixed paraffin-embedded tissues, KRAS mutations were detected at frequencies of 50% (25/50) and 52% (26/50) by PCR-rSSO and BNA-clamp PCR with Sanger sequencing, respectively, and NRAS mutations were detected at 12% (6/50) and 12% (6/50) by PCR-rSSO and BNA-clamp PCR with Sanger sequencing, respectively.	Formaldehyde	15-23	KRAS proto-oncogene, GTPase	Homo sapiens	57-61
31815201-4	2019	Here, we report that under physiological conditions, spatial learning activity elicits rapid formaldehyde generation from mitochondrial sarcosine dehydrogenase (SARDH).	Formaldehyde	93-105	sarcosine dehydrogenase	Homo sapiens	161-166
31815201-5	2019	We find that elevated formaldehyde levels facilitate spatial memory formation by enhancing N-methyl-D-aspartate (NMDA) currents, but that high formaldehyde concentrations gradually inactivate the NMDA receptor by cross-linking NR1 subunits to NR2B via the C232 residue.	Formaldehyde	143-155	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	227-230
31815201-5	2019	We find that elevated formaldehyde levels facilitate spatial memory formation by enhancing N-methyl-D-aspartate (NMDA) currents, but that high formaldehyde concentrations gradually inactivate the NMDA receptor by cross-linking NR1 subunits to NR2B via the C232 residue.	Formaldehyde	143-155	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	243-247
31815201-6	2019	We also report that in mice with aldehyde dehydrogenase-2 (ALDH2) knockout, formaldehyde accumulation due to hypofunctional ALDH2 impairs memory, consistent with observations of Alzheimer"s disease patients.	Formaldehyde	76-88	aldehyde dehydrogenase 2, mitochondrial	Mus musculus	33-57
31815201-6	2019	We also report that in mice with aldehyde dehydrogenase-2 (ALDH2) knockout, formaldehyde accumulation due to hypofunctional ALDH2 impairs memory, consistent with observations of Alzheimer"s disease patients.	Formaldehyde	76-88	aldehyde dehydrogenase 2, mitochondrial	Mus musculus	59-64
31815201-6	2019	We also report that in mice with aldehyde dehydrogenase-2 (ALDH2) knockout, formaldehyde accumulation due to hypofunctional ALDH2 impairs memory, consistent with observations of Alzheimer"s disease patients.	Formaldehyde	76-88	aldehyde dehydrogenase 2, mitochondrial	Mus musculus	124-129
31563651-9	2019	Peripheral inflammation induced by formalin disturbed spinophilin/PP1 interaction, which removed PP1-mediated inhibition and caused a marked increase of TRPV1 phosphorylation.	Formaldehyde	35-43	protein phosphatase 1, regulatory subunit 9B	Mus musculus	54-65
31563651-9	2019	Peripheral inflammation induced by formalin disturbed spinophilin/PP1 interaction, which removed PP1-mediated inhibition and caused a marked increase of TRPV1 phosphorylation.	Formaldehyde	35-43	protein phosphatase 1 catalytic subunit gamma	Mus musculus	66-69
31563651-9	2019	Peripheral inflammation induced by formalin disturbed spinophilin/PP1 interaction, which removed PP1-mediated inhibition and caused a marked increase of TRPV1 phosphorylation.	Formaldehyde	35-43	protein phosphatase 1 catalytic subunit gamma	Mus musculus	97-100
31563651-9	2019	Peripheral inflammation induced by formalin disturbed spinophilin/PP1 interaction, which removed PP1-mediated inhibition and caused a marked increase of TRPV1 phosphorylation.	Formaldehyde	35-43	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	153-158
31563651-10	2019	Viral expression of wild-type spinophilin in DRG neurons repressed TRPV1 phosphorylation and alleviated formalin-induced inflammatory pain.	Formaldehyde	104-112	protein phosphatase 1, regulatory subunit 9B	Mus musculus	30-41
31759380-6	2019	METHODS: Immunohistochemical analysis was performed to evaluate the expression of COX-2, IDO, estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) on formalin-fixed paraffin-embedded breast cancer tissues of 100 patients.	Formaldehyde	200-208	prostaglandin-endoperoxide synthase 2	Homo sapiens	82-87
31491431-9	2019	The immunogenicity of the differently treated CVB1-VLPs (non-adjuvanted) were compared in C57BL/6 J mice and animals vaccinated with formalin treated CVB1-VLPs mounted the strongest neutralising and, CVB1-specific IgG and IgG1 antibody responses.	Formaldehyde	133-141	LOC105243590	Mus musculus	222-226
31759380-6	2019	METHODS: Immunohistochemical analysis was performed to evaluate the expression of COX-2, IDO, estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) on formalin-fixed paraffin-embedded breast cancer tissues of 100 patients.	Formaldehyde	200-208	estrogen receptor 1	Homo sapiens	94-111
31759380-6	2019	METHODS: Immunohistochemical analysis was performed to evaluate the expression of COX-2, IDO, estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) on formalin-fixed paraffin-embedded breast cancer tissues of 100 patients.	Formaldehyde	200-208	erb-b2 receptor tyrosine kinase 2	Homo sapiens	155-189
31759380-6	2019	METHODS: Immunohistochemical analysis was performed to evaluate the expression of COX-2, IDO, estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) on formalin-fixed paraffin-embedded breast cancer tissues of 100 patients.	Formaldehyde	200-208	erb-b2 receptor tyrosine kinase 2	Homo sapiens	191-195
31632669-5	2019	Using formalin-fixed paraffin-embedded human tissue specimens, the expression of ANGPTL8 was investigated by reverse transcription-quantitative polymerase chain reaction (RT-qPCR), immunohistochemistry (IHC) and in situ hybridization (ISH).	Formaldehyde	6-14	angiopoietin like 8	Homo sapiens	81-88
31544361-3	2019	In the current study, the authors evaluated the concordance of HER2 status between bright-field dual in situ hybridization (DISH), fluorescence in situ hybridization (FISH), and HER2 immunohistochemistry (IHC) performed on formalin-fixed CBs of recurrent and metastatic breast cancers.	Formaldehyde	223-231	erb-b2 receptor tyrosine kinase 2	Homo sapiens	63-67
31505257-7	2019	There was no effect of repeated IFN-alpha administration on latency to respond in the hot plate test on day 4 or 7 of treatment, however, formalin-evoked nociceptive behaviour was significantly increased in IFN-alpha treated mice following 8 days of IFN-alpha administration.	Formaldehyde	138-146	interferon alpha	Mus musculus	207-216
31505257-7	2019	There was no effect of repeated IFN-alpha administration on latency to respond in the hot plate test on day 4 or 7 of treatment, however, formalin-evoked nociceptive behaviour was significantly increased in IFN-alpha treated mice following 8 days of IFN-alpha administration.	Formaldehyde	138-146	interferon alpha	Mus musculus	207-216
31505257-11	2019	Intra plantar administration of PF3845 (1 mug/10 mul) or MJN110 (1 mug/10 mul), inhibitors of AEA and 2-AG catabolism respectively, attenuated formalin-evoked hyperalgesia in IFN-alpha, but not saline-, treated mice.	Formaldehyde	143-151	interferon alpha	Mus musculus	175-184
31166645-8	2019	RESULTS: PGE2 concentration and protein levels of EP4, but not other EP receptor subtypes, in the bladder mucosa and detrusor layers were significantly increased in formalin-injected rats vs vehicle-injected control rats.	Formaldehyde	165-173	prostaglandin E receptor 4	Rattus norvegicus	50-53
31544361-12	2019	DISH can be used in tandem with IHC as a reflex assay instead of FISH and is an efficient and reliable method with which to determine HER2 amplification in formalin-fixed CBs.	Formaldehyde	156-164	erb-b2 receptor tyrosine kinase 2	Homo sapiens	134-138
31315458-10	2019	Serum and paw tissue MPO activities were decreased in treated groups with indomethacin and tannic acid according to formalin control group.	Formaldehyde	116-124	myeloperoxidase	Rattus norvegicus	21-24
31441298-8	2019	In the following test of real spiked samples of tap water and lake water, the recovery ratios of formaldehyde with the concentrations from 0.010 to 0.045 mM are tested to be between 95 and 100% by both measuring the variance in short circuit current and analyzing the color change of the cathode digitally.	Formaldehyde	97-109	nuclear RNA export factor 1	Homo sapiens	48-51
31445213-0	2019	Multi-Center Evaluation of the Fully Automated PCR-Based Idylla EGFR Mutation Assay on Formalin-Fixed, Paraffin-Embedded Tissue of Human Lung Cancer.	Formaldehyde	87-95	epidermal growth factor receptor	Homo sapiens	64-68
31645091-4	2019	Materials and Methods: The expression level of miR-374a was measured in 111 formalin-fixed paraffin-embedded lung adenocarcinoma tissues using reverse transcription-quantitative polymerase chain reaction assays.	Formaldehyde	76-84	microRNA 374a	Homo sapiens	47-55
31564566-7	2019	Higher expression of ALDOB protein was significantly correlated with MMR deficiency (d-MMR) in formalin-fixed paraffin-embedded (FFPE) patient specimens.	Formaldehyde	95-103	aldolase, fructose-bisphosphate B	Homo sapiens	21-26
31570282-0	2019	BRCA1/2 somatic mutation detection in formalin-fixed paraffin embedded tissue by next-generation sequencing in Korean ovarian cancer patients.	Formaldehyde	38-46	BRCA1 DNA repair associated	Homo sapiens	0-7
31570282-3	2019	The purpose of this study was to consider several conditions of NGS BRCA1/2 assay applicable to clinical laboratory tests, in particular for using formalin fixed paraffin embedded (FFPE) ovarian tissues.	Formaldehyde	147-155	BRCA1 DNA repair associated	Homo sapiens	68-73
31720368-11	2019	For the molecular mechanisms, Abeta could induce formaldehyde (FA) accumulation by inactivating FA dehydrogenase.	Formaldehyde	49-61	amyloid beta (A4) precursor protein	Mus musculus	30-35
31659491-0	2019	Comments to "Assessment of formaldehyde levels in relation to respiratory and allergic symptoms in children from Alba County schools, Romania" by Neamtiu et al.	Formaldehyde	27-39	afamin	Homo sapiens	113-117
31737199-5	2019	Subsequently, in 136 formalin-fixed paraffin-embedded ccRCC tissues, the increased miR-625-3p expression was correlated with poor prognosis for ccRCC patients.	Formaldehyde	21-29	microRNA 625	Homo sapiens	83-90
31653094-5	2019	BRCA1/2 status was evaluated on formalin-fixed, paraffin-embedded tumor specimens using next-generation sequencing technology.	Formaldehyde	32-40	BRCA1 DNA repair associated	Homo sapiens	0-5
31434720-4	2019	Here, we describe an improved assay for dnaJ-based identification of Enterobacteriaceae which boasts increased broad range specificity across genera, shorter amplicon sizes that are suitable for use with formalin fixed or direct patient specimens, and enhanced amplification efficiency and assay sensitivity through the incorporation of locked nucleic acid chemistries.	Formaldehyde	204-212	DnaJ heat shock protein family (Hsp40) member C14	Homo sapiens	40-44
31308097-4	2019	Similarly, RGS4KO eliminates the duration of nocifensive behavior in the second phase of the formalin assay.	Formaldehyde	93-101	regulator of G-protein signaling 4	Mus musculus	11-15
31472214-7	2019	The second aim of the present study was to examine mechanical and thermal pain thresholds as well as pain behaviors and pain-related c-Fos immunoreactivity induced by the formalin test in the amygdalas of blind and sighted mice.	Formaldehyde	171-179	FBJ osteosarcoma oncogene	Mus musculus	133-138
31472214-10	2019	Moreover, pain hypersensitivity during the formalin test was associated with increased c-Fos immunoreactivity in the amygdala.	Formaldehyde	43-51	FBJ osteosarcoma oncogene	Mus musculus	87-92
31603909-0	2019	Stabilization of alpha-synuclein oligomers using formaldehyde.	Formaldehyde	49-61	synuclein alpha	Homo sapiens	17-32
31603909-5	2019	Using the small amine-reactive cross-linker, formaldehyde (FA), we successfully stabilized alpha-syn oligomers without affecting their size, overall structure or antigenicity towards aggregate-conformation specific alpha-syn antibodies FILA and MJFR-14-6-4-2.	Formaldehyde	45-57	synuclein alpha	Homo sapiens	91-100
31603909-5	2019	Using the small amine-reactive cross-linker, formaldehyde (FA), we successfully stabilized alpha-syn oligomers without affecting their size, overall structure or antigenicity towards aggregate-conformation specific alpha-syn antibodies FILA and MJFR-14-6-4-2.	Formaldehyde	45-57	synuclein alpha	Homo sapiens	215-224
31261288-4	2019	We designed, optimized, and validated a dual-color TCF4/CD123 immunohistochemistry stain for use in formalin-fixed paraffin-embedded tissue sections.	Formaldehyde	100-108	transcription factor 4	Homo sapiens	51-55
31261288-4	2019	We designed, optimized, and validated a dual-color TCF4/CD123 immunohistochemistry stain for use in formalin-fixed paraffin-embedded tissue sections.	Formaldehyde	100-108	interleukin 3 receptor subunit alpha	Homo sapiens	56-61
30320661-5	2019	Immunohistochemical staining for MFAP5 was applied on the archival formalin-fixed paraffin-embedded blocks.	Formaldehyde	67-75	microfibril associated protein 5	Homo sapiens	33-38
31141705-5	2019	The cGAS and LSm14A genes were significantly induced in the intestines, kidney, and spleen of formalin-killed Edwardsiella tarda-treated medaka; the DHX9 and DHX36 genes were not.	Formaldehyde	94-102	protein LSM14 homolog A	Oryzias latipes	13-19
31593979-6	2019	Expression of alpha-SMA protein in CAFs of the tumor microenvironment of the 44 formalin-fixed paraffin-embedded tissue blocks from the primary tumor of OPSCC evaluated by immunohistochemistry between HPV-positive and HPV-negative tumors separated by nested polymerase chain reaction.	Formaldehyde	80-88	actin alpha 1, skeletal muscle	Homo sapiens	14-23
31141705-5	2019	The cGAS and LSm14A genes were significantly induced in the intestines, kidney, and spleen of formalin-killed Edwardsiella tarda-treated medaka; the DHX9 and DHX36 genes were not.	Formaldehyde	94-102	ATP-dependent RNA helicase A	Oryzias latipes	149-153
31141705-5	2019	The cGAS and LSm14A genes were significantly induced in the intestines, kidney, and spleen of formalin-killed Edwardsiella tarda-treated medaka; the DHX9 and DHX36 genes were not.	Formaldehyde	94-102	ATP-dependent RNA helicase DHX36	Oryzias latipes	158-163
31407509-0	2019	EGFR T790M detection in formalin-fixed paraffin-embedded tissues of patients with lung cancer using RNA-based in situ hybridization: A preliminary feasibility study.	Formaldehyde	24-32	epidermal growth factor receptor	Homo sapiens	0-4
31129114-0	2019	ML171, a specific inhibitor of NOX1 attenuates formalin induced nociceptive sensitization by inhibition of ROS mediated ERK1/2 signaling.	Formaldehyde	47-55	NADPH oxidase 1	Homo sapiens	31-35
31129114-0	2019	ML171, a specific inhibitor of NOX1 attenuates formalin induced nociceptive sensitization by inhibition of ROS mediated ERK1/2 signaling.	Formaldehyde	47-55	mitogen-activated protein kinase 3	Homo sapiens	120-126
31129114-7	2019	Here, we investigated anti-nociceptive potential of a newly identified specific NOX1 inhibitor ML171 in formalin induced inflammatory pain.	Formaldehyde	104-112	NADPH oxidase 1	Homo sapiens	80-84
31319242-5	2019	The highest average C1/C2 (formaldehyde/acetaldehyde) ratio was observed in summer (2.10) compared to those (1.33-2.03) in other seasons, implying the photochemical activities had a positive effect on increasing the ratio of C1/C2.	Formaldehyde	27-39	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	20-25
29209985-2	2019	We aimed to analyze GNAQ and GNA11 mutations in uveal melanomas using formalin-fixed, paraffin-embedded material and correlate the results with clinicopathological parameters.	Formaldehyde	70-78	G protein subunit alpha q	Homo sapiens	20-24
31538424-4	2019	We performed immuo-histochemistry for glioma-associated oncogene homolog zinc finger protein 1 (Gli1), patched, Shh, and Ptch-mediated repression of smoothened (Smo) proteins using formalin-fixed, paraffin-embedded tissue derived from primary tumors.	Formaldehyde	181-189	patched 1	Homo sapiens	121-125
31538424-4	2019	We performed immuo-histochemistry for glioma-associated oncogene homolog zinc finger protein 1 (Gli1), patched, Shh, and Ptch-mediated repression of smoothened (Smo) proteins using formalin-fixed, paraffin-embedded tissue derived from primary tumors.	Formaldehyde	181-189	smoothened, frizzled class receptor	Homo sapiens	161-164
31323253-3	2019	This study investigated the role of DLC2 and its downstream cascade of RhoA/ROCK in formalin-induced inflammatory pain using DLC2-knockout (DLC2-/-) mice and compared them with DLC2 wild-type (DLC2+/+) mice.	Formaldehyde	84-92	ras homolog family member A	Mus musculus	71-75
30974163-0	2019	Vasodilatory effect of formaldehyde via the NO/cGMP pathway and the regulation of expression of KATP, BKCa and L-type Ca2+ channels.	Formaldehyde	23-35	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	102-106
31404587-7	2019	On the other hand, although diabetes inhibits formalin-induced nociception higher protein levels of pro-inflammatory cytokine IL1-beta and chemokine CINC-1/CXCL-1 were observed.	Formaldehyde	46-54	interleukin 1 alpha	Rattus norvegicus	126-134
31404587-7	2019	On the other hand, although diabetes inhibits formalin-induced nociception higher protein levels of pro-inflammatory cytokine IL1-beta and chemokine CINC-1/CXCL-1 were observed.	Formaldehyde	46-54	C-X-C motif chemokine ligand 1	Rattus norvegicus	149-155
31404587-7	2019	On the other hand, although diabetes inhibits formalin-induced nociception higher protein levels of pro-inflammatory cytokine IL1-beta and chemokine CINC-1/CXCL-1 were observed.	Formaldehyde	46-54	C-X-C motif chemokine ligand 1	Rattus norvegicus	156-162
31579504-4	2019	Methenamine has been proposed as a useful drug for the prevention of UTI as it works as a urinary antiseptic, safely producing formaldehyde to prevent bacterial growth while avoiding bacterial resistance.	Formaldehyde	127-139	alpha-1-microglobulin/bikunin precursor	Homo sapiens	69-72
31471148-12	2019	Formalin treatment stabilizes the virus particle at elevated temperatures, and the formalin inactivated vaccine induces high levels of serum IgG1 antibodies (Th2 type response) and protective levels of neutralizing antibodies.	Formaldehyde	83-91	LOC105243590	Mus musculus	141-145
31526392-5	2019	METHODS: We performed immunohistochemical staining for S100A4 in formalin-fixed, paraffin-embedded blocks of 128 PC tissues.	Formaldehyde	65-73	S100 calcium binding protein A4	Homo sapiens	55-61
31323253-0	2019	Role of DLC2 and RhoA/ROCK pathway in formalin induced inflammatory pain in mice.	Formaldehyde	38-46	ras homolog family member A	Mus musculus	17-21
31323253-8	2019	Intrathecal administration of RhoA inhibitor (C3 exoenzyme) or ROCK inhibitor (Y27632) significantly attenuated formalin-induced inflammatory hyperalgesia in DLC2-/- mice.	Formaldehyde	112-120	ras homolog family member A	Mus musculus	30-34
31323253-13	2019	These findings indicate that DLC2 deficiency increased formalin-induced inflammatory hyperalgesia through regulating RhoA/ROCK2, and IL-1beta may be a downstream effector.	Formaldehyde	55-63	ras homolog family member A	Mus musculus	117-121
31323253-13	2019	These findings indicate that DLC2 deficiency increased formalin-induced inflammatory hyperalgesia through regulating RhoA/ROCK2, and IL-1beta may be a downstream effector.	Formaldehyde	55-63	Rho-associated coiled-coil containing protein kinase 2	Mus musculus	122-127
31323253-14	2019	Our results also suggest that RhoA/ROCK enhanced p38 activation plays an important role in formalin-induced inflammatory pain.	Formaldehyde	91-99	ras homolog family member A	Mus musculus	30-34
31323253-14	2019	Our results also suggest that RhoA/ROCK enhanced p38 activation plays an important role in formalin-induced inflammatory pain.	Formaldehyde	91-99	mitogen-activated protein kinase 14	Mus musculus	49-52
31418579-8	2019	Toward novel scaffolds for wound healing, which are stable in aqueous environment, we also introduced cross-linking of fibrinogen scaffolds in formaldehyde vapor.	Formaldehyde	143-155	fibrinogen beta chain	Homo sapiens	119-129
31492174-11	2019	Immunohistochemical staining of greater than 50% of tumor nuclei on formalin-fixed paraffin-embedded tissue using the monoclonal rabbit antibody to NUT (clone C52B1), has a specificity of 100%, and sensitivity of 87% for the diagnosis of NUT midline carcinoma.	Formaldehyde	68-76	NUT midline carcinoma family member 1	Homo sapiens	148-151
31493794-3	2019	However, identification of PAX3/7-FOXO1 fusion status is challenging when using formalin-fixed, paraffin-embedded (FFPE) material.	Formaldehyde	80-88	paired box 3	Homo sapiens	27-33
31493794-3	2019	However, identification of PAX3/7-FOXO1 fusion status is challenging when using formalin-fixed, paraffin-embedded (FFPE) material.	Formaldehyde	80-88	forkhead box O1	Homo sapiens	34-39
31261165-4	2019	We tested the PD-L1 pharmaDx qualitative immunohistochemical assay, a monoclonal rabbit anti-PD-L1, clone 28-8 intended for use in the detection of PD-L1 protein in formalin-fixed paraffin-embedded.	Formaldehyde	165-173	CD274 molecule	Homo sapiens	14-19
31356752-3	2019	Here we report on the development of a small molecule reporter conjugate (SMRC), called EC2220, which is composed of a folate ligand for FRalpha binding, a multilysine containing linker that can cross-link to FRalpha in the presence of formaldehyde fixation, and a small hapten (fluorescein) used for immunohistochemical detection.	Formaldehyde	236-248	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	137-144
31356752-3	2019	Here we report on the development of a small molecule reporter conjugate (SMRC), called EC2220, which is composed of a folate ligand for FRalpha binding, a multilysine containing linker that can cross-link to FRalpha in the presence of formaldehyde fixation, and a small hapten (fluorescein) used for immunohistochemical detection.	Formaldehyde	236-248	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	209-216
31356752-4	2019	Data show that EC2220 produces a far greater IHC signal in FRalpha-positive tissues over that produced with EC17, a folate-fluorescein SMRC that is released from the formaldehyde-denatured FRalpha protein.	Formaldehyde	166-178	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	189-196
31110050-2	2019	AIM: The rapid and fully automated Idylla EGFR Mutation Assay has been specifically designed to process formalin-fixed, paraffin-embedded sections without requiring preliminary DNA extraction.	Formaldehyde	104-112	epidermal growth factor receptor	Homo sapiens	42-46
32110249-6	2019	Fat embolism can be identified at autopsy on microscopy of the lungs using fat stains conducted on frozen tissue, including on formalin fixed but not processed tissue.	Formaldehyde	127-135	FAT atypical cadherin 1	Homo sapiens	0-3
30997532-4	2019	BRAF V600E mutation was detected using the real-time PCR in the formalin-fixed paraffin-embedded samples.	Formaldehyde	64-72	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	0-4
31190601-3	2019	METHODS: JAM-A expression levels in 44 epithelial ovarian cancer and 12 benign formalin-fixed paraffin-embedded samples were determined by reverse transcription quantitative polymerase chain reaction.	Formaldehyde	79-87	F11 receptor	Homo sapiens	9-14
31255331-2	2019	METHODS: miR-199a-3p expression in 436 formalin-fixed and 39 frozen gastric cancer tissues was investigated by in situ hybridization and RT-PCR, respectively.	Formaldehyde	39-47	microRNA 199a-1	Homo sapiens	9-20
31197258-3	2019	Here, the EuroClonality-NGS Working Group presents a multicentre technical feasibility study of a novel approach involving next-generation sequencing (NGS) of IGH and IGK loci rearrangements that is highly suitable for detecting IG gene rearrangements in frozen and formalin-fixed paraffin-embedded tissue specimens.	Formaldehyde	266-274	immunoglobulin heavy locus	Homo sapiens	159-162
31197258-3	2019	Here, the EuroClonality-NGS Working Group presents a multicentre technical feasibility study of a novel approach involving next-generation sequencing (NGS) of IGH and IGK loci rearrangements that is highly suitable for detecting IG gene rearrangements in frozen and formalin-fixed paraffin-embedded tissue specimens.	Formaldehyde	266-274	immunoglobulin kappa locus	Homo sapiens	167-170
31455202-0	2019	Visualisation of HER2 homodimers in single cells from HER2 overexpressing primary formalin fixed paraffin embedded tumour tissue.	Formaldehyde	82-90	erb-b2 receptor tyrosine kinase 2	Homo sapiens	17-21
31364853-1	2019	We study the temporal evolution of the CH2O   ClF halogen-bonded dimer following vertical ionization out of outer-valence molecular orbitals on a femtosecond time scale, employing mixed quantum-classical molecular dynamics simulations.	Formaldehyde	39-43	CLQTL1	Homo sapiens	46-49
31455202-0	2019	Visualisation of HER2 homodimers in single cells from HER2 overexpressing primary formalin fixed paraffin embedded tumour tissue.	Formaldehyde	82-90	erb-b2 receptor tyrosine kinase 2	Homo sapiens	54-58
31401730-6	2019	qPCR was performed for the HER2 gene and amyloid precursor protein (reference gene) in formalin-fixed paraffin-embedded GCa tissue.	Formaldehyde	87-95	erb-b2 receptor tyrosine kinase 2	Homo sapiens	27-31
31840034-0	2019	Genotyping of the OATP1B1 c. 521 T>C Polymorphism from the Formalin-Fixed Paraffin-Embedded (FFPE) Tissue Specimens: an Optimized Protocol.	Formaldehyde	59-67	solute carrier organic anion transporter family member 1B1	Homo sapiens	18-25
31840034-4	2019	Formalin-fixed paraffin-embedded (FFPE) liver tissues can be an enriched source for genotyping of this clinically significant OATP1B1 polymorphism in retrospective studies.	Formaldehyde	0-8	solute carrier organic anion transporter family member 1B1	Homo sapiens	126-133
30975531-12	2019	When more cycles were carried out in the mug, the values of the accumulated quantity of formaldehyde and melamine were 15.30 and 6.79 mg L-1, respectively, after thirty-two cycles.	Formaldehyde	88-100	immunoglobulin kappa variable 1-16	Homo sapiens	137-140
31446497-0	2019	Assessment of formaldehyde levels in relation to respiratory and allergic symptoms in children from Alba County schools, Romania.	Formaldehyde	14-26	afamin	Homo sapiens	100-104
31283237-6	2019	We also demonstrate the use of PES-Learn machine learning models in carrying out high-level vibrational configuration interaction computations on water and formaldehyde.	Formaldehyde	156-168	pescadillo ribosomal biogenesis factor 1	Homo sapiens	31-34
31335644-0	2019	Genetic mapping in Diversity Outbred mice identifies a Trpa1 variant influencing late-phase formalin response.	Formaldehyde	92-100	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	55-60
31313968-2	2019	Therefore, sensitive and specific monoclonal antibodies detecting PDPN are necessary for immunohistochemical analyses, especially using formalin-fixed paraffin-embedded tissues.	Formaldehyde	136-144	podoplanin	Homo sapiens	66-70
31335644-6	2019	Analysis of Diversity Outbred founder strain allele effects revealed a significant effect of the CAST/EiJ allele at Trpa1, with CAST/EiJ carrier mice showing an early, but not late, response to formalin relative to carriers of the 7 other inbred founder alleles (A/J, C57BL/6J, 129S1/SvImJ, NOD/ShiLtJ, NZO/HlLtJ, PWK/PhJ, and WSB/EiJ).	Formaldehyde	194-202	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	116-121
31335644-6	2019	Analysis of Diversity Outbred founder strain allele effects revealed a significant effect of the CAST/EiJ allele at Trpa1, with CAST/EiJ carrier mice showing an early, but not late, response to formalin relative to carriers of the 7 other inbred founder alleles (A/J, C57BL/6J, 129S1/SvImJ, NOD/ShiLtJ, NZO/HlLtJ, PWK/PhJ, and WSB/EiJ).	Formaldehyde	194-202	calpastatin	Mus musculus	97-101
31335644-6	2019	Analysis of Diversity Outbred founder strain allele effects revealed a significant effect of the CAST/EiJ allele at Trpa1, with CAST/EiJ carrier mice showing an early, but not late, response to formalin relative to carriers of the 7 other inbred founder alleles (A/J, C57BL/6J, 129S1/SvImJ, NOD/ShiLtJ, NZO/HlLtJ, PWK/PhJ, and WSB/EiJ).	Formaldehyde	194-202	calpastatin	Mus musculus	128-132
31342186-0	2019	Reaction rate of H2CO (1A) and (3A) via TST.	Formaldehyde	17-21	thiosulfate sulfurtransferase	Homo sapiens	40-43
31244108-2	2019	A proline-centered pentapeptide isoconformational to arachidonic acid, which exhibited appreciable selectivity for COX-2, overcoming acetic acid- and formalin-induced pain in rats to almost 80%, was treated as a substrate by the enzyme.	Formaldehyde	150-158	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	115-120
31158453-7	2019	Among duloxetine/CyDs complexes, succinyl-beta-CyD ameliorated the analgesic activity of duloxetine in the tail flick test and in the formalin test in mice and significantly protected the drug from CYP2D6 metabolism.	Formaldehyde	134-142	cytochrome b-245, beta polypeptide	Mus musculus	17-20
31371997-1	2019	Purpose: The aim of this study was to compare the expression of miR-21 gene in stages II-IV of formalin-fixed paraffin-embedded (FFPE) tissue in patients with colon cancer and introduce miR-21 as a potential molecular marker for detection of colon cancer in the early stages.	Formaldehyde	95-103	microRNA 21	Homo sapiens	64-70
31035147-8	2019	Besides, formaldehyde could significantly potentiated the activation of environmental stress sensitive Nrf2 pathway induced by acrolein, even at doses at which formaldehyde treatment alone had no any response.	Formaldehyde	9-21	NFE2 like bZIP transcription factor 2	Homo sapiens	103-107
30951721-7	2019	Our data showed that intradermal application of pep-GluN2A disrupted GluN2A/SHP1 interaction in DRG neurons, attenuated the ability of GluN2A subunit-containing NMDA receptors to regulate the presynaptic glutamate release and more importantly, alleviated the pain hypersensitivity caused by carrageenan, complete Freund"s adjuvant and formalin.	Formaldehyde	335-343	glutamate ionotropic receptor NMDA type subunit 2A	Homo sapiens	52-58
30951721-7	2019	Our data showed that intradermal application of pep-GluN2A disrupted GluN2A/SHP1 interaction in DRG neurons, attenuated the ability of GluN2A subunit-containing NMDA receptors to regulate the presynaptic glutamate release and more importantly, alleviated the pain hypersensitivity caused by carrageenan, complete Freund"s adjuvant and formalin.	Formaldehyde	335-343	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	76-80
31262886-3	2019	PATIENTS AND METHODS: The online genomics analysis and visualization platform, R2, developed by the Oncogenomics department at the AMC (Amsterdam, The Netherlands) was used for in silico UCK2-mRNA correlation with overall survival of pancreatic cancer patients, while UCK2 protein expression was evaluated by immunohistochemistry on pancreatic tumor formalin-fixed-paraffin-embedded sections from independent pancreatic cancer patients.	Formaldehyde	350-358	uridine-cytidine kinase 2	Homo sapiens	187-191
31164357-4	2019	We tested for cytoplasmic- and membrane-associated PCNA by FACS- and ImageStream-based staining of cell lines and IHC of human cancer formalin fixed, paraffin embedded tissues.	Formaldehyde	134-142	proliferating cell nuclear antigen	Homo sapiens	51-55
31035147-8	2019	Besides, formaldehyde could significantly potentiated the activation of environmental stress sensitive Nrf2 pathway induced by acrolein, even at doses at which formaldehyde treatment alone had no any response.	Formaldehyde	160-172	NFE2 like bZIP transcription factor 2	Homo sapiens	103-107
31115629-2	2019	Herein, we report that a novel aldehyde reductase Ykl107wp deduced from YKL107W from S. cerevisiae belongs to the classical SDR group and can catalyze the reduction reactions of acetaldehyde (AA), glycolaldehyde (GA), furfural (FF), formaldehyde (FA), and propionaldehyde (PA) but cannot reduce the six representative ketones.	Formaldehyde	233-245	short-chain dehydrogenase/reductase	Saccharomyces cerevisiae S288C	124-127
30865538-4	2019	Immunohistochemical staining for parafibromin was performed on formalin-fixed, paraffin-embedded tissue samples.	Formaldehyde	63-71	cell division cycle 73	Homo sapiens	33-45
31035147-9	2019	Furthermore, as the downstream components of Nrf2 pathway, catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPX) and heme oxygenase-1 (HO-1) were significantly synergistically induced by formaldehyde and acrolein mixtures.	Formaldehyde	209-221	NFE2 like bZIP transcription factor 2	Homo sapiens	45-49
31934100-5	2019	The relationship between the expression of miR-130a and drug resistance was detected by in situ hybridization in the formalin-fixed paraffin-embedded (FFPE) tissues from 50 breast cancer patients before and after Epirubicin-based neoadjuvant chemotherapy.	Formaldehyde	117-125	microRNA 130a	Homo sapiens	43-51
31035147-9	2019	Furthermore, as the downstream components of Nrf2 pathway, catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPX) and heme oxygenase-1 (HO-1) were significantly synergistically induced by formaldehyde and acrolein mixtures.	Formaldehyde	209-221	heme oxygenase 1	Homo sapiens	139-155
31305441-5	2019	The protein expression of PYCR1 was evaluated by immunostaining formalin-fixed, paraffin-embedded sections of RCC samples from 96 patients who underwent radical nephrectomy, and its relationship with clinical features were analyzed.	Formaldehyde	64-72	pyrroline-5-carboxylate reductase 1	Homo sapiens	26-31
31115571-0	2019	Formaldehyde induces the apoptosis of BMCs of BALB/c mice via the PTEN/PI3K/Akt signal transduction pathway.	Formaldehyde	0-12	phosphatase and tensin homolog	Mus musculus	66-70
31115571-0	2019	Formaldehyde induces the apoptosis of BMCs of BALB/c mice via the PTEN/PI3K/Akt signal transduction pathway.	Formaldehyde	0-12	thymoma viral proto-oncogene 1	Mus musculus	76-79
31016433-3	2019	We performed immunohistochemistry for CD8 (cytotoxic T cells (CTL)), FOXP3 (regulatory T cells (Tregs)), and GATA3 (Th2 cells) in 106 formalin-fixed paraffin-embedded invasive breast cancer tissue samples and analyzed both the numbers and percentages of investigated cells in tumor-associated infiltrates.	Formaldehyde	134-142	CD8a molecule	Homo sapiens	38-41
30426328-0	2019	Comparison of Three Real-Time PCR Assays for the Detection of PIK3CA Somatic Mutations in Formalin-Fixed Paraffin Embedded Tissues of Patients with Breast Carcinomas.	Formaldehyde	90-98	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	62-68
31016433-3	2019	We performed immunohistochemistry for CD8 (cytotoxic T cells (CTL)), FOXP3 (regulatory T cells (Tregs)), and GATA3 (Th2 cells) in 106 formalin-fixed paraffin-embedded invasive breast cancer tissue samples and analyzed both the numbers and percentages of investigated cells in tumor-associated infiltrates.	Formaldehyde	134-142	forkhead box P3	Homo sapiens	69-74
31016433-3	2019	We performed immunohistochemistry for CD8 (cytotoxic T cells (CTL)), FOXP3 (regulatory T cells (Tregs)), and GATA3 (Th2 cells) in 106 formalin-fixed paraffin-embedded invasive breast cancer tissue samples and analyzed both the numbers and percentages of investigated cells in tumor-associated infiltrates.	Formaldehyde	134-142	GATA binding protein 3	Homo sapiens	109-114
31701048-6	2019	Methods: We developed FHR5 staining protocols for formalin-fixed paraffin-embedded (FFPE) renal tissue and applied them to surplus biopsy sections from a C3G cohort.	Formaldehyde	50-58	complement factor H related 5	Homo sapiens	22-26
31220107-6	2019	eEF1A2 protein level was measured in formalin-fixed paraffin-embedded tissues by immunohistochemistry in a semi-quantitative manner (sum of the percentage of positive cells x staining intensity) on a scale from 0 to 300.	Formaldehyde	37-45	eukaryotic translation elongation factor 1 alpha 2	Homo sapiens	0-6
31656498-3	2019	Materials and methods: Chromogenic in situ hybridization (CISH) was used to identify CCND1 amplification on formalin-fixed paraffin-embedded invasive ductal carcinoma, in which immunohistochemistry (IHC) had previously been performed in order to evaluate the pathological relevance of Cyclin D1 overexpression in human breast cancer (n = 138).	Formaldehyde	108-116	cyclin D1	Homo sapiens	85-90
31208108-5	2019	Materials and Method: We performed a literature search for miR expression in EC using MEDLINE, PubMed (the Internet portal of the National Library of Medicine) and The Cochrane Library, Cochrane databases "Cochrane Reviews" and "Clinical Trials" using the following keywords: microRNA, endometrial cancer, prognosis, diagnosis, lymph node, survival, plasma, FFPE (formalin-fixed, paraffin-embedded).	Formaldehyde	364-372	membrane associated ring-CH-type finger 8	Homo sapiens	59-62
31197538-7	2019	It was then extended to image and quantitatively evaluate HER2 homodimers in clinical formalin-fixed paraffin-embedded breast cancer tissue specimens.	Formaldehyde	86-94	erb-b2 receptor tyrosine kinase 2	Homo sapiens	58-62
31194830-0	2019	Development of novel monoclonal antibodies with specific binding affinity for denatured human CD26 in formalin-fixed paraffin-embedded and decalcified specimens.	Formaldehyde	102-110	dipeptidyl peptidase 4	Homo sapiens	94-98
31194830-3	2019	The development of an anti-human CD26 mAb that can clearly and reliably detect the denatured CD26 molecule in formalin-fixed paraffin-embedded (FFPE) tissues in the clinical setting is therefore of the utmost importance.	Formaldehyde	110-118	dipeptidyl peptidase 4	Homo sapiens	33-37
31194830-3	2019	The development of an anti-human CD26 mAb that can clearly and reliably detect the denatured CD26 molecule in formalin-fixed paraffin-embedded (FFPE) tissues in the clinical setting is therefore of the utmost importance.	Formaldehyde	110-118	dipeptidyl peptidase 4	Homo sapiens	93-97
31092032-3	2019	Immunofluorescence staining with otopetrin-2 (rabbit affinity purified polyclonal antibody) and GFAP (mouse monoclonal antibody) to identify vestibular supporting cells was made in formalin fixed cryostat sections or whole microdissected utricle (for flat mount preparations).	Formaldehyde	181-189	glial fibrillary acidic protein	Oryctolagus cuniculus	96-100
30582714-2	2019	METHODS: To optimize screening for monoclonal antibodies suitable for immunohistochemistry on formalin-fixed, paraffin-embedded tissues, we developed a new enzyme-linked immunosorbent assay using formalin-fixed, paraffin-embedded cells overexpressing human PAC1 receptors.	Formaldehyde	196-204	ADCYAP receptor type I	Homo sapiens	257-261
31069565-6	2019	Our study evaluated the expression of C-NFkappaB proteins (p65, p50, and c-Rel) by using immunohistochemistry on sections from 75 formalin-fixed UM.	Formaldehyde	130-138	nuclear factor kappa B subunit 1	Homo sapiens	38-48
31127887-0	2019	Detection of Epidermal Growth Factor Receptor (EGFR) Gene Mutation in Formalin Fixed Paraffin Embedded Tissue by Polymerase Chain Reaction-Single Strand Conformational Polymorphism (PCR-SSCP) in Non-Small Cell Lung Cancer in the Northeastern Region of Thailand Background: The use of targeted specific genes in therapeutic and treatment decisions has been considered forlung cancer.	Formaldehyde	70-78	epidermal growth factor receptor	Homo sapiens	13-45
30721543-4	2019	We used chromatin immunoprecipitation and formaldehyde-assisted isolation of regulatory elements followed by sequencing to show that PU.1 transcription factor binding motifs were overrepresented at active cis-regulatory regions in both murine BMMs and OCs, while IRF and NFAT binding motifs were selectively enriched at these regions in BMMs and OCs, respectively.	Formaldehyde	42-54	spleen focus forming virus (SFFV) proviral integration oncogene	Mus musculus	133-137
31161965-2	2019	Therefore, sensitive and specific monoclonal antibodies (mAbs) targeting PDPN are needed for immunohistochemical analyses using formalin-fixed paraffin-embedded tissues.	Formaldehyde	128-136	podoplanin	Cricetulus griseus	73-77
30607480-8	2019	GLP-1 (0.2 mg/kg) and GLP-2 (0.05, 0.1, 0.2 mg/kg) significantly decreased formalin-induced licking and shaking behaviors.	Formaldehyde	75-83	glucagon	Mus musculus	0-5
30607480-8	2019	GLP-1 (0.2 mg/kg) and GLP-2 (0.05, 0.1, 0.2 mg/kg) significantly decreased formalin-induced licking and shaking behaviors.	Formaldehyde	75-83	glucagon-like peptide 2 receptor	Mus musculus	22-27
31036353-3	2019	In the present study, we examined CAV-1 expression in specimens from CAMR patients using an immunoenzymatic technique with formalin-fixed tissues.	Formaldehyde	123-131	caveolin 1	Homo sapiens	34-39
31036353-12	2019	CONCLUSION: CAV-1 expression in PTC had a score &gt;=2 in all cases, indicating that an adequate level of staining of formalin-fixed tissue was attained with the present immunoenzymatic technique.	Formaldehyde	118-126	caveolin 1	Homo sapiens	12-17
31232941-5	2019	Formalin-fixed paraffin-embedded samples were exploited for miR-222 quantitative reverse transcriptase- polymerase chain reaction (RT-PCR) analysis.	Formaldehyde	0-8	microRNA 222	Homo sapiens	60-67
30980234-0	2019	Hydrogen Sulfide Inhibits Formaldehyde-Induced Senescence in HT-22 Cells via Upregulation of Leptin Signaling.	Formaldehyde	26-38	leptin	Mus musculus	93-99
31186735-5	2019	The expression of PD-L1 in 47 formalin-fixed, paraffin-embedded, NSCLC specimens was assessed using IHC and reverse transcription-quantitative polymerase chain reaction (RT-qPCR).	Formaldehyde	30-38	CD274 molecule	Homo sapiens	18-23
31127887-0	2019	Detection of Epidermal Growth Factor Receptor (EGFR) Gene Mutation in Formalin Fixed Paraffin Embedded Tissue by Polymerase Chain Reaction-Single Strand Conformational Polymorphism (PCR-SSCP) in Non-Small Cell Lung Cancer in the Northeastern Region of Thailand Background: The use of targeted specific genes in therapeutic and treatment decisions has been considered forlung cancer.	Formaldehyde	70-78	epidermal growth factor receptor	Homo sapiens	47-51
30818256-2	2019	By using a strategy that combines LC-PDA/UV-MSn with mechanism-based stress studies, the unknown peak was rapidly identified as cyanomethyl mirabegron, a solution degradant that is caused by a Strecker-like reaction between the API, formaldehyde (an impurity in PEG), and HCN (an impurity in HPLC grade acetonitrile).	Formaldehyde	233-245	moesin	Homo sapiens	44-47
30715728-0	2019	Remarkable shifts of Csp2 -H and O-H stretching frequencies and stability of complexes of formic acid with formaldehydes and thioformaldehydes.	Formaldehyde	107-120	regulator of calcineurin 2	Homo sapiens	21-25
31109149-9	2019	ICV and ARC injection of ghrelin significantly reduced pain in all phases of the formalin test (p < 0.001).	Formaldehyde	81-89	ghrelin and obestatin prepropeptide	Rattus norvegicus	25-32
30653681-0	2019	Determination of formaldehyde in single cell by capillary electrophoresis with LIF detection.	Formaldehyde	17-29	LIF interleukin 6 family cytokine	Homo sapiens	79-82
31060525-6	2019	METHODS: The expression levels of miR-944 were detected using quantitative reverse transcription polymerase chain reaction in five types of cervical cancer cell lines and 116 formalin-fixed paraffin-embedded (FFPE) cervical tissues.	Formaldehyde	175-183	microRNA 944	Homo sapiens	34-41
31092453-0	2019	Association Between Formalin Fixation Time and Programmed Cell Death Ligand 1 Expression in Patients With Non-Small Cell Lung Cancer.	Formaldehyde	20-28	CD274 molecule	Homo sapiens	47-77
31092453-1	2019	BACKGROUND/AIM: The expression of programmed cell death ligand 1 (PD-L1) determined by immunohistochemistry (IHC) may be associated with tissue formalin fixation time in non-small cell lung cancer (NSCLC) samples.	Formaldehyde	144-152	CD274 molecule	Homo sapiens	34-64
31092453-1	2019	BACKGROUND/AIM: The expression of programmed cell death ligand 1 (PD-L1) determined by immunohistochemistry (IHC) may be associated with tissue formalin fixation time in non-small cell lung cancer (NSCLC) samples.	Formaldehyde	144-152	CD274 molecule	Homo sapiens	66-71
31092453-2	2019	We investigated the association between the PD-L1 expression and formalin fixation time, and clarified the optimal duration of fixation for accurate PD-L1 evaluation.	Formaldehyde	65-73	CD274 molecule	Homo sapiens	44-49
31050216-2	2019	In particular, robust IHC assays performed on formalin-fixed, paraffin-embedded (FFPE) tumor tissue are widely used as surrogate markers for ALK and ROS1 rearrangements and for detecting programmed death ligand 1 (PD-L1) expression in patients with advanced NSCLC; in addition, they have become essential for treatment decisions.	Formaldehyde	46-54	ALK receptor tyrosine kinase	Homo sapiens	141-144
30443013-3	2019	We evaluated K17 expression by immunohistochemistry in formalin-fixed, paraffin embedded tissue specimens of non-papillary invasive urothelial carcinoma (UC) (classical histological cases), high grade papillary UC (PUC-LG), low grade papillary UC (PUC-HG), papillary urothelial neoplasia of low malignant potential (PUNLMP), and normal bladder mucosa.	Formaldehyde	55-63	keratin 17	Homo sapiens	13-16
30765126-5	2019	Glomerular expression of PLA2R was analyzed in stored, formalin-fixed, paraffin-embedded kidney biopsy sections.	Formaldehyde	55-63	phospholipase A2 receptor 1	Homo sapiens	25-30
30846412-5	2019	RESULTS: Sample DNA quality for KRAS mutation test was better in biopsy specimens, which showed markedly shorter cold ischemia time and shorter formalin fixation time compared to resection specimens.	Formaldehyde	144-152	KRAS proto-oncogene, GTPase	Homo sapiens	32-36
31030490-1	2019	Methods: Records of 132 women with EOC were reviewed.Immunostaining of PD-L1 was performed with formalin-fixed, paraffin-embedded specimens.	Formaldehyde	96-104	CD274 molecule	Homo sapiens	71-76
30690119-5	2019	Furthermore, in western blot analysis, oral administration of sinomenine resulted in a significant blockage of spinal extracellular signal-regulated protein kinase (ERK1/2) activation induced by formalin.	Formaldehyde	195-203	mitogen-activated protein kinase 3	Mus musculus	165-171
30882204-6	2019	We used the ImCal method to quantify HER2 in 35 breast cancer formalin-fixed paraffin-embedded patient samples, revealing a high degree of heterogeneity among patients, which contrasts with the homogeneous immunohistochemistry patient classification.	Formaldehyde	62-70	erb-b2 receptor tyrosine kinase 2	Homo sapiens	37-41
30952761-4	2019	PIK3CA mutations were identified in formalin-fixed and paraffin-embedded surgical specimens from 112 patients with EBV-GC with available tumor tissue samples.	Formaldehyde	36-44	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	0-6
31050216-2	2019	In particular, robust IHC assays performed on formalin-fixed, paraffin-embedded (FFPE) tumor tissue are widely used as surrogate markers for ALK and ROS1 rearrangements and for detecting programmed death ligand 1 (PD-L1) expression in patients with advanced NSCLC; in addition, they have become essential for treatment decisions.	Formaldehyde	46-54	ROS proto-oncogene 1, receptor tyrosine kinase	Homo sapiens	149-153
31050216-2	2019	In particular, robust IHC assays performed on formalin-fixed, paraffin-embedded (FFPE) tumor tissue are widely used as surrogate markers for ALK and ROS1 rearrangements and for detecting programmed death ligand 1 (PD-L1) expression in patients with advanced NSCLC; in addition, they have become essential for treatment decisions.	Formaldehyde	46-54	CD274 molecule	Homo sapiens	187-212
31050216-2	2019	In particular, robust IHC assays performed on formalin-fixed, paraffin-embedded (FFPE) tumor tissue are widely used as surrogate markers for ALK and ROS1 rearrangements and for detecting programmed death ligand 1 (PD-L1) expression in patients with advanced NSCLC; in addition, they have become essential for treatment decisions.	Formaldehyde	46-54	CD274 molecule	Homo sapiens	214-219
31007744-4	2019	Furthermore, the expression level of CFHL1 was evaluated in 76 pairs of formalin-fixed, paraffin-embedded (FFPE) HCC and peritumoral tissues (expression pattern cohort), and 278 FFPE HCC tissues (prognostic cohort) using tissue microarray-based immunohistochemistry.	Formaldehyde	72-80	complement factor H related 1	Homo sapiens	37-42
30944626-4	2019	The expression of GRHL1 was detected by immunohistochemistry in 266 formalin-fixed paraffin-embedded ESCC samples with the help of Pearson"s chi2 test, and Cox regression analysis was employed in order to distinguish independent prognostic factors.	Formaldehyde	68-76	grainyhead like transcription factor 1	Homo sapiens	18-23
30772446-2	2019	We previously found that intracerebroventricular injection of 26RFa produces an analgesic effect in a rat formalin test.	Formaldehyde	106-114	pyroglutamylated RFamide peptide	Rattus norvegicus	62-67
30772446-3	2019	In the present study, we directly tested the hypothesis that the analgesic effects of 26RFa in the formalin test are mediated in well-recognized regions of the descending inhibitory pain pathways, such as the rostral ventromedial medulla (RVM), locus coeruleus (LC), and periaqueductal grey (PAG) in rats.	Formaldehyde	99-107	pyroglutamylated RFamide peptide	Rattus norvegicus	86-91
30772446-9	2019	Microinjection of 26RFa into the LC contralateral, but not ipsilateral, to the formalin injection site significantly decreased the number of flinching behaviors compared with that of saline-injected rats.	Formaldehyde	79-87	pyroglutamylated RFamide peptide	Rattus norvegicus	18-23
31061899-1	2019	Sensitive and specific monoclonal antibodies (mAbs) targeting podoplanin (PDPN) are needed for immunohistochemical analyses using formalin-fixed paraffin-embedded tissues because PDPN is known as a lymphatic endothelial cell maker in pathology.	Formaldehyde	130-138	podoplanin	Cricetulus griseus	74-78
31105829-7	2019	Additionally, in 42 cases of renal cancer formalin-fixed paraffin-embedded specimens, patients with higher expression levels of miR-378a-5p had significantly longer overall survival rates (P&lt;0.05) than patients with lower miR-378a-5p expression levels.	Formaldehyde	42-50	MLX interacting protein	Homo sapiens	128-131
29869529-5	2019	FDH inactivity and semicarbazide-sensitive amine oxidase (SSAO) disorder resulted in endogenous formaldehyde (FA) accumulation.	Formaldehyde	96-108	alcohol dehydrogenase 5 (class III), chi polypeptide	Mus musculus	0-3
29869529-5	2019	FDH inactivity and semicarbazide-sensitive amine oxidase (SSAO) disorder resulted in endogenous formaldehyde (FA) accumulation.	Formaldehyde	96-108	amine oxidase, copper containing 3	Mus musculus	19-56
29869529-5	2019	FDH inactivity and semicarbazide-sensitive amine oxidase (SSAO) disorder resulted in endogenous formaldehyde (FA) accumulation.	Formaldehyde	96-108	amine oxidase, copper containing 3	Mus musculus	58-62
31633047-2	2019	Methods: (i) DKK-4 protein expression was analyzed by immunohistochemical staining with anti-DKK-4 antibody using archived formalin-fixed paraffin-embedded specimens obtained at surgery from 122 patients with colorectal cancer, and its association with clinicopathological findings was also investigated.	Formaldehyde	123-131	dickkopf WNT signaling pathway inhibitor 4	Homo sapiens	13-18
29135534-1	2019	Preliminary data suggest that tumor expression of programmed cell death ligand 1 (PD-L1) protein in human cancers, as determined by immunohistochemistry in formalin-fixed, paraffin-embedded tissue samples, may predict clinical response to anti-PD-1/PD-L1 therapy.	Formaldehyde	156-164	CD274 molecule	Homo sapiens	50-80
29135534-1	2019	Preliminary data suggest that tumor expression of programmed cell death ligand 1 (PD-L1) protein in human cancers, as determined by immunohistochemistry in formalin-fixed, paraffin-embedded tissue samples, may predict clinical response to anti-PD-1/PD-L1 therapy.	Formaldehyde	156-164	CD274 molecule	Homo sapiens	82-87
29135534-3	2019	The aim of the current study was to examine PD-L1 expression in formalin-fixed, paraffin-embedded malignant and nonmalignant cells from human tumors to establish potential characteristic patterns of PD-L1 expression in tumor tissues.	Formaldehyde	64-72	CD274 molecule	Homo sapiens	44-49
30600586-0	2019	Overexpressed Hsp70 alleviated formaldehyde-induced apoptosis partly via PI3K/Akt signaling pathway in human bronchial epithelial cells.	Formaldehyde	31-43	heat shock protein family A (Hsp70) member 4	Homo sapiens	14-19
30600586-0	2019	Overexpressed Hsp70 alleviated formaldehyde-induced apoptosis partly via PI3K/Akt signaling pathway in human bronchial epithelial cells.	Formaldehyde	31-43	AKT serine/threonine kinase 1	Homo sapiens	78-81
30666643-9	2019	Tissue inflammation, evident as increased myeloperoxidase activity, and IL-1alpha, IL-1beta, and IL-6 levels inside the prostate, but not in the bladder, following intraprostatic formalin injection induced an increase in NGF expression in the bladder urothelium, which depended on activation of the pelvic nerve.	Formaldehyde	179-187	myeloperoxidase	Rattus norvegicus	42-57
30710424-4	2019	It was found that SIRT1 was overexpressed in 300 (62%) of 485 formalin-fixed paraffin-embedded NSCLC tissues.	Formaldehyde	62-70	sirtuin 1	Homo sapiens	18-23
30996419-3	2019	The nanocomposite based biosensor shows comparatively high sensitivity (527 microA mg/L-1 cm-2), low detection limit (0.05 mg/L) in linear detection range 0.05-0.5 mg/L for formaldehyde detection using formaldehyde dehydrogenase (FDH) enzyme.	Formaldehyde	173-185	L1 cell adhesion molecule	Homo sapiens	86-94
30996419-3	2019	The nanocomposite based biosensor shows comparatively high sensitivity (527 microA mg/L-1 cm-2), low detection limit (0.05 mg/L) in linear detection range 0.05-0.5 mg/L for formaldehyde detection using formaldehyde dehydrogenase (FDH) enzyme.	Formaldehyde	173-185	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	202-228
30996419-3	2019	The nanocomposite based biosensor shows comparatively high sensitivity (527 microA mg/L-1 cm-2), low detection limit (0.05 mg/L) in linear detection range 0.05-0.5 mg/L for formaldehyde detection using formaldehyde dehydrogenase (FDH) enzyme.	Formaldehyde	173-185	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	230-233
30666643-9	2019	Tissue inflammation, evident as increased myeloperoxidase activity, and IL-1alpha, IL-1beta, and IL-6 levels inside the prostate, but not in the bladder, following intraprostatic formalin injection induced an increase in NGF expression in the bladder urothelium, which depended on activation of the pelvic nerve.	Formaldehyde	179-187	interleukin 1 alpha	Rattus norvegicus	72-81
30716345-2	2019	This method involves the use of the AOX enzyme that could specifically oxidize methanol, giving rise to equimolar equivalents each of formaldehyde (HCHO) and hydrogen peroxide (H2O2) as the end products.	Formaldehyde	134-146	acyl-CoA oxidase 1	Homo sapiens	36-39
30666643-9	2019	Tissue inflammation, evident as increased myeloperoxidase activity, and IL-1alpha, IL-1beta, and IL-6 levels inside the prostate, but not in the bladder, following intraprostatic formalin injection induced an increase in NGF expression in the bladder urothelium, which depended on activation of the pelvic nerve.	Formaldehyde	179-187	interleukin 1 alpha	Rattus norvegicus	83-91
30666643-9	2019	Tissue inflammation, evident as increased myeloperoxidase activity, and IL-1alpha, IL-1beta, and IL-6 levels inside the prostate, but not in the bladder, following intraprostatic formalin injection induced an increase in NGF expression in the bladder urothelium, which depended on activation of the pelvic nerve.	Formaldehyde	179-187	interleukin 6	Rattus norvegicus	97-101
30666643-9	2019	Tissue inflammation, evident as increased myeloperoxidase activity, and IL-1alpha, IL-1beta, and IL-6 levels inside the prostate, but not in the bladder, following intraprostatic formalin injection induced an increase in NGF expression in the bladder urothelium, which depended on activation of the pelvic nerve.	Formaldehyde	179-187	nerve growth factor	Rattus norvegicus	221-224
30984013-0	2019	Formaldehyde Induces Mesenteric Artery Relaxation via a Sensitive Transient Receptor Potential Ankyrin-1 (TRPA1) and Endothelium-Dependent Mechanism: Potential Role in Postprandial Hyperemia.	Formaldehyde	0-12	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	66-104
30984013-0	2019	Formaldehyde Induces Mesenteric Artery Relaxation via a Sensitive Transient Receptor Potential Ankyrin-1 (TRPA1) and Endothelium-Dependent Mechanism: Potential Role in Postprandial Hyperemia.	Formaldehyde	0-12	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	106-111
30984555-6	2019	Expression profile of ERp29 in 94 osteosarcoma cases was investigated using immunohistochemically stained on formalin-fixed paraffin-embedded biopsied tissue.	Formaldehyde	109-117	endoplasmic reticulum protein 29	Homo sapiens	22-27
30517841-3	2019	Therefore, here we investigated the application of matrix assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) together with immunohistochemical analyses (IHC) using MT-1/2 antibody for MT detection in formalin-fixed paraffin-embedded (FFPE) biopsy specimens of human skin.	Formaldehyde	224-232	metallothionein 1I, pseudogene	Homo sapiens	188-194
30907880-7	2019	We utilize the efficient crosslinking activity of formaldehyde to fix PKR-RNA complexes and isolate them via immunoprecipitation.	Formaldehyde	50-62	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	70-73
30827467-7	2019	Concordance of 100% was observed between droplet digital PCR and sequencing-based orthogonal methods in the detection of TERT mutant DNA in 32 formalin-fixed, paraffin-embedded melanoma tumors.	Formaldehyde	143-151	telomerase reverse transcriptase	Homo sapiens	121-125
30716345-4	2019	In another set up, the amount of formaldehyde produced as a sequel to the oxidation of methanol by the AOX enzyme was determined by allowing it to react with the acetylacetanilide reagent, after which the volume of the fluorescent product - 3,5-di-N-phenylacetyl-1,4-dihydrolutidine (colorless product; lambdaex/em = 390/470 nm) that was generated was estimated by measuring its emission at 460 nm (excitation wavelength at 360 nm) in a spectrophotometer.	Formaldehyde	33-45	acyl-CoA oxidase 1	Homo sapiens	103-106
30811471-0	2019	Integrated routine workflow using next-generation sequencing and a fully-automated platform for the detection of KRAS, NRAS and BRAF mutations in formalin-fixed paraffin embedded samples with poor DNA quality in patients with colorectal carcinoma.	Formaldehyde	146-154	KRAS proto-oncogene, GTPase	Homo sapiens	113-117
30797498-4	2019	Standard immunohistochemistry was performed on formalin-fixed paraffin-embedded tissue sections using antibody against LC3A autophagic potein.	Formaldehyde	47-55	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	119-123
30811471-0	2019	Integrated routine workflow using next-generation sequencing and a fully-automated platform for the detection of KRAS, NRAS and BRAF mutations in formalin-fixed paraffin embedded samples with poor DNA quality in patients with colorectal carcinoma.	Formaldehyde	146-154	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	128-132
30842953-0	2019	Formalin fixation on HER-2 and PD-L1 expression in gastric cancer: A pilot analysis using the same surgical specimens with different fixation times.	Formaldehyde	0-8	erb-b2 receptor tyrosine kinase 2	Homo sapiens	21-26
30842953-0	2019	Formalin fixation on HER-2 and PD-L1 expression in gastric cancer: A pilot analysis using the same surgical specimens with different fixation times.	Formaldehyde	0-8	CD274 molecule	Homo sapiens	31-36
30906321-8	2019	OB-R transcript (in fresh tissues) and proteins (in formalin-fixed and paraffin-embedded specimens) were expressed in all PTC tissues examined, with no significant differences between BRAF-mutated and BRAF-wild-type tumors.	Formaldehyde	52-60	leptin receptor	Homo sapiens	0-4
30446169-9	2019	Remarkable concentrations of the sum of phenols and formaldehyde were detected also at the outflow of the Revelva river into the sea (R12) and were 0.24 mg L-1 in June and 0.35 mg L-1 in September 2016.	Formaldehyde	52-64	L1 cell adhesion molecule	Homo sapiens	156-159
30446169-9	2019	Remarkable concentrations of the sum of phenols and formaldehyde were detected also at the outflow of the Revelva river into the sea (R12) and were 0.24 mg L-1 in June and 0.35 mg L-1 in September 2016.	Formaldehyde	52-64	L1 cell adhesion molecule	Homo sapiens	180-183
30781400-3	2019	In this context, we evaluated the infiltration of FoxP3+ Tregs on 205 human formalin-fixed paraffin-embedded HNSCC and we assessed its prognostic value compared to other potential prognostic factors, including HPV infection.	Formaldehyde	76-84	forkhead box P3	Homo sapiens	50-55
29084060-1	2019	Interpretative criteria for programmed death-ligand 1 (PD-L1) immunohistochemistry (IHC) have been largely based on data from formalin-fixed, paraffin-embedded tissues, despite the fact that cytologic specimens, especially cell blocks, are often the only or most readily available tissue for testing.	Formaldehyde	126-134	CD274 molecule	Homo sapiens	55-60
30873315-6	2019	Among the as-prepared GCN hybrid materials, GCN-5 QDs exhibit excellent CO2 reductive activity for the generation of formaldehyde, HCHO (10.3 mmol h-1 g-1).	Formaldehyde	117-129	lysine acetyltransferase 2A	Homo sapiens	44-49
30110125-2	2019	In a mass spectrometry-based global proteomic study of 44 formalin-fixed, paraffin-embedded (FFPE) primary TNBC tumors and 10 corresponding metastases, we found that Cytochrome P450 reductase (CYPOR) expression correlated with patient outcome.	Formaldehyde	58-66	cytochrome p450 oxidoreductase	Homo sapiens	193-198
30655337-4	2019	Here, comparing formaldehyde to alternative fixatives we clarify the nature of the chromosomal association of previously proposed BFs in embryonic stem cells: While ESRRB can be considered as a canonical BF that binds at selected regulatory regions in mitosis, SOX2 and POU5F1 (also known as OCT4) establish DNA sequence-independent interactions with the mitotic chromosomes, either throughout the chromosomal arms (SOX2) or at pericentromeric regions (POU5F1).	Formaldehyde	16-28	estrogen related receptor beta	Homo sapiens	165-170
30657411-0	2019	Development and Characterization of a Novel Monoclonal Antibody Against Chitinase-like Protein CHID1 Applicable for Immunohistochemistry on Formalin Fixed Paraffin-Embedded Sections.	Formaldehyde	140-148	chitinase domain containing 1	Homo sapiens	95-100
30783512-5	2019	The TGFbeta-EMT signature was validated as prognostic of 5-year MFS in 3 cohorts: a 133 NSCLC tumor dataset (P = 0.0002), a NanoString assays of RNA isolated from formalin-fixed paraffin-embedded samples from these same tumors (P = 0.0015), and a previously published NSCLC MFS dataset (P = 0.0015).	Formaldehyde	163-171	transforming growth factor beta 1	Homo sapiens	4-11
30838039-6	2019	Results: The concordance rate of HER2 amplification examined in plasma and formalin-fixed paraffin-embedded (FFPE) samples with ddPCR was 81.4%, with a sensitivity of 76.5% and a specificity of 83.8%.	Formaldehyde	75-83	erb-b2 receptor tyrosine kinase 2	Homo sapiens	33-37
30691436-3	2019	METHODS: In the present study, we examined the concordance of droplet digital PCR (ddPCR, in combination with immunohistochemistry, IHC) with FISH for MYCN detection in a panel of formalin-fixed paraffin-embedded (FFPE) human neuroblastoma samples.	Formaldehyde	180-188	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	151-155
30395894-9	2019	Immunohistochemistry results showed that EGCG could activate the Nrf2 signaling pathway, thus alleviating the oxidative damage caused by formaldehyde.	Formaldehyde	137-149	nuclear factor, erythroid derived 2, like 2	Mus musculus	65-69
30522268-8	2019	The rate-determining step involves the cleavage of the PLP-serine aldimine Calpha-Cbeta bond and the formation of formaldehyde in line with experimental evidence.	Formaldehyde	114-126	pyridoxal phosphatase	Homo sapiens	55-58
30666091-8	2019	Next-generation sequencing of formalin-fixed paraffin-embedded RC tissues showed MDM2 amplification without MDM4 amplification, EGFR aberrations, or DNMT3A alterations.	Formaldehyde	30-38	MDM2 proto-oncogene	Homo sapiens	81-85
30467745-3	2019	While CBr2O + OH + HO2 produced on the singlet PES is subdominant to the overall reaction under the typical atmospheric condition below 300 K. Due to higher energy barriers surmounted, other products including CBr2O2 + H2O2, CBr2O + HO3H, CH2O + HO3Br, CHBrO + HO3 + Br, and CHBr2OH + O3 make minor contributions to the overall reaction.	Formaldehyde	239-243	heme oxygenase 2	Homo sapiens	19-22
30622248-4	2019	STAT5 protein catalyzes multicomponent reactions of a phosphate mimetic, formaldehyde, and 1H-tetrazoles yielding protein ligands with greatly increased binding affinity and ligand efficiency.	Formaldehyde	73-85	signal transducer and activator of transcription 5A	Mus musculus	0-5
30609930-6	2019	To validate the underlying mechanism for PLCE1 in constitutive activation of the NF-kappaB signaling pathway, we performed studies using in vitro and in vivo assays and samples from 368 formalin-fixed esophageal cancer tissues and 215 normal tissues with IHC using tissue microarrays and the Cancer Genome Atlas dataset.	Formaldehyde	186-194	phospholipase C, epsilon 1	Mus musculus	41-46
30525577-3	2019	Here, formaldehyde is obtained as dimethoxymethane, its dimethyl acetal, by selective reduction of carbon dioxide at moderate temperatures (90  C) and partial pressures (90 bar H2/20 bar CO2) in the presence of methanol.	Formaldehyde	6-18	relaxin 2	Homo sapiens	177-182
30939888-1	2019	Histochemical diagnosis of Hirschsprung s disease at our institution was introduced in the 1970s, calretinin imunohistochemistry on formalin fixed tissue was newly added in 2015.	Formaldehyde	132-140	calbindin 2	Homo sapiens	98-108
30467745-3	2019	While CBr2O + OH + HO2 produced on the singlet PES is subdominant to the overall reaction under the typical atmospheric condition below 300 K. Due to higher energy barriers surmounted, other products including CBr2O2 + H2O2, CBr2O + HO3H, CH2O + HO3Br, CHBrO + HO3 + Br, and CHBr2OH + O3 make minor contributions to the overall reaction.	Formaldehyde	239-243	histidyl-tRNA synthetase 2, mitochondrial	Homo sapiens	233-236
31198984-6	2019	Immunohistochemistry (IHC) was used to determine the presence of WNT5A protein in the sections of formalin-fixed, paraffin-embedded tissue specimens derived from unchanged endome-trial controls (n = 6) and EC tumors (n = 19).	Formaldehyde	98-106	Wnt family member 5A	Homo sapiens	65-78
30115565-3	2019	METHODS: MUC13 immunohistochemical staining was performed on surgically resected formalin-fixed tissue specimens from 49 IPMNs and 23 non-mucinous cysts.	Formaldehyde	81-89	mucin 13, cell surface associated	Homo sapiens	9-14
30536359-2	2019	The negative effects of formaldehyde were described using vascular endothelial growth factor (VEGF), matrix metallopeptidase 2 (MMP-2) and osteonectin antibodies involved in the extracellular matrix and angiogenetic development.	Formaldehyde	24-36	vascular endothelial growth factor A	Rattus norvegicus	58-92
30536359-2	2019	The negative effects of formaldehyde were described using vascular endothelial growth factor (VEGF), matrix metallopeptidase 2 (MMP-2) and osteonectin antibodies involved in the extracellular matrix and angiogenetic development.	Formaldehyde	24-36	matrix metallopeptidase 2	Rattus norvegicus	101-126
30536359-2	2019	The negative effects of formaldehyde were described using vascular endothelial growth factor (VEGF), matrix metallopeptidase 2 (MMP-2) and osteonectin antibodies involved in the extracellular matrix and angiogenetic development.	Formaldehyde	24-36	secreted protein acidic and cysteine rich	Rattus norvegicus	139-150
30536359-10	2019	Interestingly, VEGF expression in the formaldehyde group was the most significant finding between the two groups (p < 0.001).	Formaldehyde	38-50	vascular endothelial growth factor A	Rattus norvegicus	15-19
30536359-11	2019	When compared inflammation, MMP-2 and osteonectin expressions were significant (p < 0.01) in the formaldehyde group.	Formaldehyde	97-109	matrix metallopeptidase 2	Rattus norvegicus	28-33
30536359-11	2019	When compared inflammation, MMP-2 and osteonectin expressions were significant (p < 0.01) in the formaldehyde group.	Formaldehyde	97-109	secreted protein acidic and cysteine rich	Rattus norvegicus	38-49
30536359-12	2019	CONCLUSIONS: It was suggested that formaldehyde toxicity decreased the expression of MMP-2 and in osteoblasts as well as affecting the retention of MMP levels in tooth cavity, which is very low in collagen fibres.	Formaldehyde	35-47	matrix metallopeptidase 2	Rattus norvegicus	85-90
30536359-12	2019	CONCLUSIONS: It was suggested that formaldehyde toxicity decreased the expression of MMP-2 and in osteoblasts as well as affecting the retention of MMP levels in tooth cavity, which is very low in collagen fibres.	Formaldehyde	35-47	matrix metallopeptidase 2	Rattus norvegicus	85-88
30531088-9	2019	Formaldehyde elevated mRNA and protein levels of TRPA1 and CGRP, as well as the proportion of TRPA1- and CGRP-positive neurons.	Formaldehyde	0-12	transient receptor potential cation channel subfamily A member 1	Homo sapiens	49-54
29902563-5	2019	Here, we present a high-throughput sequencing method that allows the mapping of in vivo DROSHA cleavage sites at single nucleotide resolution, termed formaldehyde crosslinking, immunoprecipitation, and sequencing (fCLIP-seq).	Formaldehyde	150-162	drosha ribonuclease III	Homo sapiens	88-94
30268943-0	2019	A Single-Tube, EuroClonality-Inspired, TRG Clonality Multiplex PCR Aids Management of Patients with Enteropathic Diseases, including from Formaldehyde-Fixed, Paraffin-Embedded Tissues.	Formaldehyde	138-150	T cell receptor gamma locus	Homo sapiens	39-42
30531088-9	2019	Formaldehyde elevated mRNA and protein levels of TRPA1 and CGRP, as well as the proportion of TRPA1- and CGRP-positive neurons.	Formaldehyde	0-12	calcitonin related polypeptide alpha	Homo sapiens	59-63
30531088-11	2019	Furthermore, the effects of formaldehyde, but not menthol, on CGRP expression were blocked by pretreatment with PD98059.	Formaldehyde	28-40	calcitonin related polypeptide alpha	Homo sapiens	62-66
30655796-0	2019	Use of ANGPTL2 mRNA levels in formalin-fixed paraffin-embedded tissues as a biomarker to diagnose gastric cancer and to evaluate the extent of vascular invasion.	Formaldehyde	30-38	angiopoietin like 2	Homo sapiens	7-14
30627644-8	2018	We found that BDNF deletion in the adult altered few itch or acute and chronic pain behaviors, beyond sexually dimorphic phenotypes in the tail immersion, histamine, and formalin tests.	Formaldehyde	170-178	brain derived neurotrophic factor	Mus musculus	14-18
30504376-1	2018	AIM: To evaluate cyclin-dependent kinase inhibitor 2A (CDKN2A) and cytokeratin 7 (CK7) expression in cervical intraepithelial neoplasia (CIN) formalin-fixed samples.	Formaldehyde	142-150	cyclin dependent kinase inhibitor 2A	Homo sapiens	17-53
31556562-5	2019	BRCA1/2 Next Generation Sequencing (NGS)-based analysis of formalin-fixed paraffin-embedded (FFPE) ovarian cancer samples becomes the standard of care.	Formaldehyde	59-67	BRCA1 DNA repair associated	Homo sapiens	0-7
30539907-4	2018	Methods: PAI-1 expression was detected by tissue microarray-based immunohistochemical staining in formalin-fixed paraffin-embedded specimens from 93 PDAC patients with surgical resection from September 2004 to December 2008.	Formaldehyde	98-106	serpin family E member 1	Homo sapiens	9-14
30218661-4	2018	In this study, megalin and cubilin were localized by immunohistochemistry using affinity-purified antibodies in formalin fixed frozen cryostat and celloidin embedded sections of the human inner ear.	Formaldehyde	112-120	LDL receptor related protein 2	Homo sapiens	15-22
30218661-4	2018	In this study, megalin and cubilin were localized by immunohistochemistry using affinity-purified antibodies in formalin fixed frozen cryostat and celloidin embedded sections of the human inner ear.	Formaldehyde	112-120	cubilin	Homo sapiens	27-34
30568859-5	2018	Methods: We performed guanidine extraction and polymerase chain reaction (PCR) amplification/sequencing of a fragment of the cytochrome c oxidase I (COI) gene on tissue fragments preserved in low-pH formalin for up to 3 weeks and in neutral buffered formalin for up to 4 weeks.	Formaldehyde	199-207	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	149-152
30568859-5	2018	Methods: We performed guanidine extraction and polymerase chain reaction (PCR) amplification/sequencing of a fragment of the cytochrome c oxidase I (COI) gene on tissue fragments preserved in low-pH formalin for up to 3 weeks and in neutral buffered formalin for up to 4 weeks.	Formaldehyde	250-258	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	149-152
30568859-7	2018	Results: The COI fragment of all oligochaete specimens preserved in neutral buffered formalin for up to 28 days was successfully amplified by PCR and obtained sequences were complete and of high quality.	Formaldehyde	85-93	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	13-16
30563489-0	2018	A novel detection methodology for HER2 protein quantitation in formalin-fixed, paraffin embedded clinical samples using fluorescent nanoparticles: an analytical and clinical validation study.	Formaldehyde	63-71	erb-b2 receptor tyrosine kinase 2	Homo sapiens	34-38
30558648-5	2018	METHODS: We measured CD68, CD163, and MMP-9 protein expression in formalin-fixed paraffin-embedded tissues of breast carcinomas represented in tissue microarray format using multiplexed quantitative immunofluorescence (QIF) in two independent Yale cohorts: cohort A-n = 398, estrogen receptor-positive (ER+) and ER- cases-and the triple-negative breast cancer (TNBC)-only cohort B (n = 160).	Formaldehyde	66-74	matrix metallopeptidase 9	Homo sapiens	38-43
30521571-2	2018	Formalin-fixed paraffin-embedded tumor tissue samples were collected from 227 patients, considered to be HER2-positive when assessed at the local laboratories.	Formaldehyde	0-8	erb-b2 receptor tyrosine kinase 2	Homo sapiens	105-109
30504376-1	2018	AIM: To evaluate cyclin-dependent kinase inhibitor 2A (CDKN2A) and cytokeratin 7 (CK7) expression in cervical intraepithelial neoplasia (CIN) formalin-fixed samples.	Formaldehyde	142-150	cyclin dependent kinase inhibitor 2A	Homo sapiens	55-61
30504376-1	2018	AIM: To evaluate cyclin-dependent kinase inhibitor 2A (CDKN2A) and cytokeratin 7 (CK7) expression in cervical intraepithelial neoplasia (CIN) formalin-fixed samples.	Formaldehyde	142-150	keratin 7	Homo sapiens	67-80
30504376-1	2018	AIM: To evaluate cyclin-dependent kinase inhibitor 2A (CDKN2A) and cytokeratin 7 (CK7) expression in cervical intraepithelial neoplasia (CIN) formalin-fixed samples.	Formaldehyde	142-150	keratin 7	Homo sapiens	82-85
30264546-3	2018	In this study, IDO1 expression in tumor cells (T-IDO1) was frequently detected (109/112) by immunohistochemistry in formalin-fixed paraffin-embedded specimens from HCC patients, and the expression patterns were mostly focal (102/109).	Formaldehyde	116-124	indoleamine 2,3-dioxygenase 1	Homo sapiens	15-19
30370669-5	2018	The authors also analyze the participation of oncoproteins such as fibulins, FGFR1, HER2/neu, FBI-1, and MUC1-C in the control of genes related to formaldehyde metabolism, suggesting the existence of two mutually exclusive processes in cancer cells: 1) production and 2) oxidation and elimination of formaldehyde from the cell.	Formaldehyde	147-159	fibroblast growth factor receptor 1	Homo sapiens	77-82
30370669-5	2018	The authors also analyze the participation of oncoproteins such as fibulins, FGFR1, HER2/neu, FBI-1, and MUC1-C in the control of genes related to formaldehyde metabolism, suggesting the existence of two mutually exclusive processes in cancer cells: 1) production and 2) oxidation and elimination of formaldehyde from the cell.	Formaldehyde	147-159	erb-b2 receptor tyrosine kinase 2	Homo sapiens	84-88
30370669-5	2018	The authors also analyze the participation of oncoproteins such as fibulins, FGFR1, HER2/neu, FBI-1, and MUC1-C in the control of genes related to formaldehyde metabolism, suggesting the existence of two mutually exclusive processes in cancer cells: 1) production and 2) oxidation and elimination of formaldehyde from the cell.	Formaldehyde	147-159	erb-b2 receptor tyrosine kinase 2	Homo sapiens	89-92
30370669-5	2018	The authors also analyze the participation of oncoproteins such as fibulins, FGFR1, HER2/neu, FBI-1, and MUC1-C in the control of genes related to formaldehyde metabolism, suggesting the existence of two mutually exclusive processes in cancer cells: 1) production and 2) oxidation and elimination of formaldehyde from the cell.	Formaldehyde	147-159	zinc finger and BTB domain containing 7A	Homo sapiens	94-99
30370669-5	2018	The authors also analyze the participation of oncoproteins such as fibulins, FGFR1, HER2/neu, FBI-1, and MUC1-C in the control of genes related to formaldehyde metabolism, suggesting the existence of two mutually exclusive processes in cancer cells: 1) production and 2) oxidation and elimination of formaldehyde from the cell.	Formaldehyde	147-159	mucin 1, cell surface associated	Homo sapiens	105-109
30264546-3	2018	In this study, IDO1 expression in tumor cells (T-IDO1) was frequently detected (109/112) by immunohistochemistry in formalin-fixed paraffin-embedded specimens from HCC patients, and the expression patterns were mostly focal (102/109).	Formaldehyde	116-124	indoleamine 2,3-dioxygenase 1	Homo sapiens	49-53
30121940-3	2018	We performed immunohistochemistry (IHC) for PD-L1 on formalin-fixed paraffin-embedded tissues.	Formaldehyde	53-61	CD274 molecule	Homo sapiens	44-49
29938855-2	2018	PD-L1 IHC assays have been clinically validated only on formalin-fixed paraffin-embedded tissue; however, lung cancer is frequently diagnosed on cytology.	Formaldehyde	56-64	CD274 molecule	Homo sapiens	0-5
30391779-8	2018	We found that the use of fixatives other than 10% neutral buffered formalin significantly reduced the HER2-positive rate.	Formaldehyde	67-75	erb-b2 receptor tyrosine kinase 2	Homo sapiens	102-106
30130298-7	2018	Finally, spinal 12/15-lipoxygenase inhibition by nordihydroguaiaretic acid (NDGA) both prevents phase II formalin flinching and reverses formalin-induced persistent tactile allodynia.	Formaldehyde	105-113	arachidonate 15-lipoxygenase	Rattus norvegicus	16-34
30674365-4	2018	METHODS: Immunohistochemistry for cyclooxygenase-2 was performed on a total of 100 oral squamous cell carcinoma formalin-fixed, paraffin-embedded blocks.	Formaldehyde	112-120	prostaglandin-endoperoxide synthase 2	Homo sapiens	34-50
30527198-2	2018	Currently, only formalin-fixed paraffin-embedded samples are acceptable for PD-L1 immunostaining with the anti-PD-L1 antibodies 22-C3 and SP263.	Formaldehyde	16-24	CD274 molecule	Homo sapiens	76-81
30242969-5	2018	Quantitative real-time polymerase chain reaction-based validation in an independent clinical cohort (n = 88) of formalin-fixed paraffin-embedded clinical GC samples showed that MRC-derived high-risk patients succumb to significantly poor recurrence-free survival in GC patients (P &lt; 0.0001).	Formaldehyde	112-120	CD200 molecule	Homo sapiens	177-180
30130298-7	2018	Finally, spinal 12/15-lipoxygenase inhibition by nordihydroguaiaretic acid (NDGA) both prevents phase II formalin flinching and reverses formalin-induced persistent tactile allodynia.	Formaldehyde	137-145	arachidonate 15-lipoxygenase	Rattus norvegicus	16-34
30244634-4	2018	METHODS: Expression of miR-146b-5p and miR-146b-3p was assessed in formalin-fixed paraffin-embedded (FFPE) tissues samples of PTC patients and the relationship with lymph node metastasis was analyzed.. A variety of PTC cells including BHP10-3 and K1 cells were cultured and miR-146b-5p or miR-146b-3p were over-expressed with microRNA mimics.	Formaldehyde	67-75	microRNA 146b	Homo sapiens	23-31
30391423-5	2018	Our results showed that formalin injection caused significant spontaneous pain behaviors and increased the expressions of the mu-opioid receptor, c-Fos and phosphorylated extracellular signal-regulated kinase (p-ERK1/2) in the ipsilateral trigeminal ganglion (TG).	Formaldehyde	24-32	FBJ osteosarcoma oncogene	Mus musculus	146-151
30391423-7	2018	Four hours after formalin injection, the level of c-Fos immunoreactivity in the ipsilateral TG neurons was much lower in mice pretreated with DN-9 or morphine.	Formaldehyde	17-25	FBJ osteosarcoma oncogene	Mus musculus	50-55
30059880-8	2018	Exposure to DINP and/or formaldehyde also induced an increase in IL-1beta, IL-17, and NGF.	Formaldehyde	24-36	interleukin 1 beta	Mus musculus	65-73
30213873-9	2018	We revealed that low levels of miR-150 and high levels of its target, FOXP1, are associated with shorter overall survival in FL and suggest that miR-150 could serve as a good biomarker measurable in formalin-fixed paraffin-embedded tissue.	Formaldehyde	199-207	forkhead box P1	Homo sapiens	70-75
30213873-9	2018	We revealed that low levels of miR-150 and high levels of its target, FOXP1, are associated with shorter overall survival in FL and suggest that miR-150 could serve as a good biomarker measurable in formalin-fixed paraffin-embedded tissue.	Formaldehyde	199-207	microRNA 150	Homo sapiens	145-152
30662627-0	2018	Droplet digital PCR for detection of BRAF V600E mutation in formalin-fixed, paraffin-embedded melanoma tissues: a comparison with Cobas  4800, Sanger sequencing, and allele-specific PCR.	Formaldehyde	60-68	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	37-41
30059880-8	2018	Exposure to DINP and/or formaldehyde also induced an increase in IL-1beta, IL-17, and NGF.	Formaldehyde	24-36	interleukin 17A	Mus musculus	75-80
30348769-7	2018	As an indication of reduced pain sensitivity, these orexin-DREADD mice took longer to respond to the 55  C thermal stimuli in the hot plate test and exhibited significantly less frequent licking of the formalin-injected paw in the formalin test.	Formaldehyde	202-210	hypocretin	Mus musculus	52-58
30571462-11	2018	Because GSNO-R also acts as a formaldehyde dehydrogenase, we examined postischemic formaldehyde levels and found that they were nearly 2-fold higher in N6022-treated female hearts compared with nontreated hearts.	Formaldehyde	30-42	alcohol dehydrogenase 5 (class III), chi polypeptide	Mus musculus	8-14
30571462-13	2018	CONCLUSIONS: These striking findings point to GSNO-R as a critical sex-dependent mediator of myocardial protein SNO and formaldehyde levels and further suggest that different therapeutic strategies may be required to combat ischemic heart disease in males and females.	Formaldehyde	120-132	alcohol dehydrogenase 5 (class III), chi polypeptide	Mus musculus	46-52
30348769-7	2018	As an indication of reduced pain sensitivity, these orexin-DREADD mice took longer to respond to the 55  C thermal stimuli in the hot plate test and exhibited significantly less frequent licking of the formalin-injected paw in the formalin test.	Formaldehyde	231-239	hypocretin	Mus musculus	52-58
30306752-0	2018	Serum Periostin Is Negatively Correlated With Exposure to Formaldehyde and Volatile Organic Compounds in Children.	Formaldehyde	58-70	periostin	Homo sapiens	6-15
30306752-3	2018	To the best of our knowledge, this is the first study to show significant inverse correlations between serum periostin concentration and exposure to xylene and formaldehyde in children.	Formaldehyde	160-172	periostin	Homo sapiens	109-118
30306752-4	2018	Our findings suggested the need for caution in using the serum periostin level as a marker for allergic diseases, since exposure to volatile organic compounds and formaldehyde may confound the interpretation of these results.	Formaldehyde	163-175	periostin	Homo sapiens	63-72
30010043-7	2018	RESULTS: After detection of the CUX1-ALK fusion gene, RNA sequencing analysis of formalin-fixed paraffin-embedded sections from the primary tumor specimen was applied to reveal a 97-nucleotide fragment from CUX1 intron 8 inserted before the nucleotide 53 position in ALK exon 20.	Formaldehyde	81-89	cut like homeobox 1	Homo sapiens	207-211
29189264-10	2018	CONCLUSIONS: Our study is the first to show CD123 is positive in a subset of formalin-fixed, paraffin-embedded MGZLs and CHLs, in contrast to PMBL which is largely negative.	Formaldehyde	77-85	interleukin 3 receptor subunit alpha	Homo sapiens	44-49
30410061-3	2018	METHODS: We developed a proximity ligation assay to detect ER and PR-B (ER:PR-B) interactions in formalin-fixed paraffin-embedded tissues.	Formaldehyde	97-105	RB transcriptional corepressor 1	Homo sapiens	66-70
30410061-3	2018	METHODS: We developed a proximity ligation assay to detect ER and PR-B (ER:PR-B) interactions in formalin-fixed paraffin-embedded tissues.	Formaldehyde	97-105	RB transcriptional corepressor 1	Homo sapiens	75-79
30062819-5	2018	TREX1 distribution in human brain was further evaluated by immunohistochemical analyses of formalin-fixed, paraffin-embedded samples from normal controls and patients with RVCL and ischemic stroke.	Formaldehyde	91-99	three prime repair exonuclease 1	Homo sapiens	0-5
29511342-2	2018	Mice lacking the main formaldehyde-detoxifying gene Adh5 combined with the loss of the Fanconi anemia (FA) DNA repair pathway rapidly succumbed to bone marrow failure (BMF) primarily due to the extensive ablation of the hematopoietic stem cell (HSC) pool.	Formaldehyde	22-34	alcohol dehydrogenase 5 (class III), chi polypeptide	Mus musculus	52-56
29511342-5	2018	We show that Adh5- or FA-deficient cells are hypersensitive to formaldehyde and to THF, presenting DNA damage and genome instability.	Formaldehyde	63-75	alcohol dehydrogenase 5 (class III), chi polypeptide	Mus musculus	13-17
29589283-0	2018	Detecting Alpha Synuclein Seeding Activity in Formaldehyde-Fixed MSA Patient Tissue by PMCA.	Formaldehyde	46-58	synuclein alpha	Homo sapiens	10-25
29589283-8	2018	Using our protocol, we detected alpha-syn seeding activity from a histologically positive, formaldehyde-fixed MSA sample, but not with the histologically negative, formaldehyde-fixed control sample.	Formaldehyde	91-103	synuclein alpha	Homo sapiens	32-41
30226548-7	2018	MCT4 expression was associated with T stage (P=0.001), N stage (P=0.020) and formalin-fixed and paraffin-embedded (TNM) stage (P=0.042).	Formaldehyde	77-85	solute carrier family 16 member 3	Homo sapiens	0-4
29406329-5	2018	BRAF V600E status was assessed by pyrosequencing of DNA extracted from excess formalin-fixed, paraffin-embedded surgical material.	Formaldehyde	78-86	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	0-4
30774885-3	2019	Herein, we first show that simple homodimers of acetone and formaldehyde can serve as models to understand the effect of relative orientations of the two carbonyl groups on the nature of CO   CO interactions.	Formaldehyde	60-72	DAN domain BMP antagonist family member 5	Homo sapiens	187-194
30386718-2	2018	PD-L1 expression was evaluated by immunohistochemistry (IHC) using formalin-fixed paraffin-embedded (FFPE) specimens from 45 non-ccRCC patients with available tissue.	Formaldehyde	67-75	CD274 molecule	Homo sapiens	0-5
30121557-2	2018	In this synthesis process of T-MIR, 2-acrylamide-2- methylpropanesulfonic acid (AMPS) and acrylamide (AAm) were coupled as zipper-like thermo-responsive monomers, resorcinol, and melamine as hydrophilic monomers, formaldehyde as a cross-linker, and berberine chloride (BerbC) as the template.	Formaldehyde	213-225	membrane associated ring-CH-type finger 8	Homo sapiens	31-34
30322013-6	2018	Quantitative real-time RT-PCR of RNA extracted from formalin-fixed paraffin-embedded (FFPE) samples showed that the relative expression of miR-143 was higher in GBM patients compared to control individuals.	Formaldehyde	52-60	microRNA 143	Homo sapiens	139-146
30188114-6	2018	In particular very high emission rates were estimated of two relevant indoor air pollutants, formaldehyde and acetaldehyde as 355 mug h-1 and 257 mug h-1 for 1 m2, respectively.	Formaldehyde	93-105	H1.5 linker histone, cluster member	Homo sapiens	134-162
30245393-8	2018	In turn, the pure TRPA1 antagonists 16 and 27 revealed a statistically significant antiallodynic effect in the formalin test and in the von Frey test performed in both phases of oxaliplatin-induced allodynia.	Formaldehyde	111-119	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	18-23
30299371-0	2018	Detection of IDH1 and IDH2 Mutation in Formalin-fixed Paraffin-embedded Gliomas Using Allele-specific COLD-PCR and Probe Melting Curve Analysis.	Formaldehyde	39-47	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	13-17
30201265-5	2018	Firstly, we performed immunohistochemical staining, qRT-PCR and western blotting to determine PDGFRalpha expression in formalin-fixed, paraffin-embedded tissue sections from 78 NKTCL cases and in cell lines.	Formaldehyde	119-127	platelet derived growth factor receptor alpha	Homo sapiens	94-104
30323667-3	2018	Patients and methods: We investigated PD-L1 expression immunohistochemistry in formalin-fixed, paraffin-embedded tissues from 192 ICC patients undergoing curative resection and correlated our results with the clinicopathologic features and prognosis.	Formaldehyde	79-87	CD274 molecule	Homo sapiens	38-43
30275220-3	2018	In this study, we established a monoclonal antibody against KK-LC-1 to detect its protein expression in formalin-fixed samples.	Formaldehyde	104-112	cancer/testis antigen 83	Homo sapiens	60-67
30299371-0	2018	Detection of IDH1 and IDH2 Mutation in Formalin-fixed Paraffin-embedded Gliomas Using Allele-specific COLD-PCR and Probe Melting Curve Analysis.	Formaldehyde	39-47	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	22-26
29694840-1	2018	A thermo-stable purified serine hydroxymethyltransferase (SHMT; 418 AA) was used for the carrier free immobilization using pectin as a coach molecule and formaldehyde as a cross-linker.	Formaldehyde	154-166	serine hydroxymethyltransferase 1	Homo sapiens	25-56
29514107-4	2018	The novel ALK fusion was identified by a 5"-rapid amplification of cDNA ends-based system optimized for formalin-fixed, paraffin-embedded tissue.	Formaldehyde	104-112	ALK receptor tyrosine kinase	Homo sapiens	10-13
29694840-1	2018	A thermo-stable purified serine hydroxymethyltransferase (SHMT; 418 AA) was used for the carrier free immobilization using pectin as a coach molecule and formaldehyde as a cross-linker.	Formaldehyde	154-166	serine hydroxymethyltransferase 1	Homo sapiens	58-62
29802359-0	2018	Duplications of KIAA1549 and BRAF screening by Droplet Digital PCR from formalin-fixed paraffin-embedded DNA is an accurate alternative for KIAA1549-BRAF fusion detection in pilocytic astrocytomas.	Formaldehyde	72-80	KIAA1549	Homo sapiens	16-24
30774681-4	2018	Methods: We performed chromogenic in situ hybridization (CISH) to detect the sub-cellular localization of miR-21 in 25 formalin-fixed, paraffin-embedded (FFPE) samples of WT.	Formaldehyde	119-127	microRNA 21	Homo sapiens	106-112
30019152-5	2018	In both strains (GS115/hIFN-gamma and GS115/hIFN-gamma/SR) more than 95% of formaldehyde flux is directed towards assimilatory pathway.	Formaldehyde	76-88	interferon gamma	Homo sapiens	23-33
30019152-5	2018	In both strains (GS115/hIFN-gamma and GS115/hIFN-gamma/SR) more than 95% of formaldehyde flux is directed towards assimilatory pathway.	Formaldehyde	76-88	interferon gamma	Homo sapiens	44-54
29802359-0	2018	Duplications of KIAA1549 and BRAF screening by Droplet Digital PCR from formalin-fixed paraffin-embedded DNA is an accurate alternative for KIAA1549-BRAF fusion detection in pilocytic astrocytomas.	Formaldehyde	72-80	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	29-33
28913610-3	2018	Immunohistochemical staining was used to verify eEF2 protein in a set of 97 formalin-fixed, paraffin-embedded primary PCa tissues.	Formaldehyde	76-84	eukaryotic translation elongation factor 2	Homo sapiens	48-52
30310305-7	2018	The time spent on rubbing directed to the injected area and c-Fos immunoreactivity in TNC was measured as the formalin-induced pain-related behavior, and as the marker of pain-related neuronal activation, respectively.	Formaldehyde	110-118	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	60-65
30149991-3	2018	Methylation at 39 CpGs in the MEN1 promoter were assessed in formalin fixed, paraffin embedded parathyroid tissue.	Formaldehyde	61-69	menin 1	Homo sapiens	30-34
30174290-3	2018	Here, we capture these dsRNAs by formaldehyde-mediated crosslinking and immunoprecipitation sequencing and find that various noncoding RNAs interact with PKR.	Formaldehyde	33-45	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	154-157
30294590-14	2018	We detected the MYD88 p.L265P mutation in formalin fixed paraffin embedded (FFPE) tissue from the brain biopsy and the CSF-ctDNA.	Formaldehyde	42-50	MYD88 innate immune signal transduction adaptor	Homo sapiens	16-21
30241382-4	2018	Here, we evaluated ZKSCAN3 expression in uterine cervical cancers (CC) by immunohistochemistry using formalin-fixed, paraffin-embedded tissues from 126 biopsy samples from 126 patients.	Formaldehyde	101-109	zinc finger with KRAB and SCAN domains 3	Homo sapiens	19-26
29540329-4	2018	METHODS: Herein, we assessed the EGFR mutation status of 26 formalin fixed-paraffin embedded (FFPE) samples of lung adenocarcinoma.	Formaldehyde	60-68	epidermal growth factor receptor	Homo sapiens	33-37
29981815-5	2018	The rPLD1 toxin was converted into toxoid (the first toxoid of H. lepturus PLD) with a 0.25% concentration of formalin and stored for ten days at room temperature.	Formaldehyde	110-118	phospholipase D1	Rattus norvegicus	4-9
30373862-5	2018	Thus, the aim of this study was to compare CE, AGE, and PAGE to MTHFR C677T polymorphism analysis of Formalin-Fixed and Paraffin-Embedded (FFPE) cervical samples.	Formaldehyde	101-109	methylenetetrahydrofolate reductase	Homo sapiens	64-69
30075175-5	2018	Furthermore, RT-qPCR was performed to study the expression of miR-302b in bladder cancer tissues and the prognostic value of altered miR-302b expression with 48 formalin-fixed paraffin-embedded bladder urothelial carcinoma samples.	Formaldehyde	161-169	microRNA 302b	Homo sapiens	133-141
30160021-0	2018	Stability of oestrogen and progesterone receptor antigenicity in formalin-fixed paraffin-embedded breast cancer tissue over time.	Formaldehyde	65-73	progesterone receptor	Homo sapiens	27-48
29866615-3	2018	HER2 immunohistochemistry was performed using formalin-fixed, paraffin-embedded primary tumor specimens.	Formaldehyde	46-54	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-4
29981867-5	2018	We evaluated the diagnostic value of different methods to detect IDH2 mutations in formalin-fixed, paraffin-embedded tumor samples.	Formaldehyde	83-91	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	65-69
29510150-6	2018	administration of GnIH (RFRP) blocks morphine-induced analgesia in hot plate and formalin injection tests in rats suggesting that GnIH increases sensitivity to pain.	Formaldehyde	81-89	gonadotropin inhibitory hormone peptides	Coturnix japonica	18-22
29510150-6	2018	administration of GnIH (RFRP) blocks morphine-induced analgesia in hot plate and formalin injection tests in rats suggesting that GnIH increases sensitivity to pain.	Formaldehyde	81-89	neuropeptide VF precursor	Rattus norvegicus	24-28
29920815-4	2018	Gene expression profiling of formalin-fixed, paraffin-embedded specimens from 40 human ACTH-secreting pituitary adenomas revealed the significant expression of genes involved in protein biosynthesis and ribosomal function, in keeping with the neuroendocrine cell profile.	Formaldehyde	29-37	proopiomelanocortin	Homo sapiens	87-91
30282403-0	2018	Contribution of Spinal PKCgamma Expression to Short- and Long-lasting Pain Behaviors in Formalin-induced Inflamed Mice.	Formaldehyde	88-96	protein kinase C, gamma	Mus musculus	23-31
29936257-2	2018	We investigated the sensitivity of BRCA1/2 variant analysis in formalin-fixed, paraffin-embedded tumor tissue using a combination of next-generation sequencing and copy number variant multiplex ligation-dependent probe amplification.	Formaldehyde	63-71	BRCA1 DNA repair associated	Homo sapiens	35-40
29986951-5	2018	Oral administration of NYX-2925 resulted in rapid and long-lasting analgesia in both of the neuropathic pain models and formalin-induced persistent pain, but was ineffective in the tail flick model.	Formaldehyde	120-128	nyctalopin	Rattus norvegicus	23-26
30015848-4	2018	In the present study, we evaluated the expression of AHR/HSP-90 in 25 formalin-fixed, paraffin-embedded human oral cancer specimens by IHC analysis.	Formaldehyde	70-78	aryl hydrocarbon receptor	Homo sapiens	53-56
30015848-4	2018	In the present study, we evaluated the expression of AHR/HSP-90 in 25 formalin-fixed, paraffin-embedded human oral cancer specimens by IHC analysis.	Formaldehyde	70-78	heat shock protein 90 alpha family class A member 1	Homo sapiens	57-63
30282403-2	2018	OBJECTIVE: This study aimed to characterize the contribution of spinal PKCgamma to spontaneous pain and long-lasting bilateral hyperalgesia in formalin-induced inflamed mice using pharmacological inhibition.	Formaldehyde	143-151	protein kinase C, gamma	Mus musculus	71-79
30282403-13	2018	RESULTS: The number of PKCgamma-immunoreactive (ir) spinal neurons was significantly higher at 10 days, but not 2 hours, after formalin intraplantar injection, and accompanied by long-lasting bilateral hyperalgesia.	Formaldehyde	127-135	protein kinase C, gamma	Mus musculus	23-31
30181812-5	2018	Materials and Methods: Analysis of the BRAF mutation status of eight formalin-fixed paraffin-embedded (FFPE) tissue samples was performed using a CE-IVD fully-automated (FA) PCR-based platform.	Formaldehyde	69-77	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	39-43
29790189-3	2018	Here, we describe the characterization of a unique antibody identified using human antibody phage display that can recognize CD133 in both formalin-fixed tissues and cell lines.	Formaldehyde	139-147	prominin 1	Homo sapiens	125-130
30115035-0	2018	PIK3CA mutation is a favorable prognostic factor in esophageal cancer: molecular profile by next-generation sequencing using surgically resected formalin-fixed, paraffin-embedded tissue.	Formaldehyde	145-153	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	0-6
29525349-3	2018	PATIENTS AND METHODS: Clinical data and formalin-fixed paraffin-embedded tissues of pT1 UBC treated with an organ-preserving approach was analyzed retrospectively.	Formaldehyde	40-48	zinc finger protein 77	Homo sapiens	84-87
30009773-1	2018	AIMS: To investigate whether immunohistochemistry (IHC) could be used to screen BRAF mutation status in formalin-fixed paraffin-embedded (FFPE) colorectal carcinoma (CRC) and papillary thyroid carcinoma (PTC) samples.	Formaldehyde	104-112	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	80-84
29607465-3	2018	We previously optimized measurement of mTORC1"s kinase activity in AML blasts during clinical trials using serial phospho-specific flow cytometry of formaldehyde-fixed whole blood or marrow specimens.	Formaldehyde	149-161	CREB regulated transcription coactivator 1	Mus musculus	39-45
30175411-2	2018	We evaluated the expression level of miR-1247-5p in 224 formalin-fixed, paraffin-embedded specimens (112 BC and matched cancer free tissues) by quantitative real-time reverse transcriptase polymerase chain reaction (qRT-PCR).	Formaldehyde	56-64	microRNA 1247	Homo sapiens	37-45
29738835-6	2018	For a better recognition of cellular morphology and a better distinction between gametogenic (healthy) and atretic follicles, also a single labeling immunolocalization of OXA on formalin fixed paraffin embedded tissues and a TUNEL staining were performed.	Formaldehyde	178-186	hypocretin neuropeptide precursor	Sus scrofa	171-174
30233874-8	2018	Methods: Mutations in EGFR gene were examined using real-time PCR technique in 1,108 formalin-fixed paraffin-embedded (FFPE) tissues, 398 FFPE cell-blocks and 470 cytological specimens of NSCLC.	Formaldehyde	85-93	epidermal growth factor receptor	Homo sapiens	22-26
30032824-5	2018	MATERIALS AND METHODS: We developed a Droplet Digital PCR (ddPCR) assay to measure HOXA9 promoter methylation in formalin-fixed paraffin-embedded (FFPE) biospecimens generated during routine pathology.	Formaldehyde	113-121	homeobox A9	Homo sapiens	83-88
29752984-7	2018	First, we evaluated the formalin-evoked protein expression of the immediate early gene, c-fos.	Formaldehyde	24-32	FBJ osteosarcoma oncogene	Mus musculus	88-93
29808228-2	2018	Two experiments were conducted to assess: (1) whether repeated forced swim stress for 3 days increased the number of Fos-positive neurons evoked by masseter muscle injury due to formalin injection; and (2) whether serotonin-reuptake inhibitor, fluoxetine, administered daily after each stress conditioning, had modulatory roles on Fos expression.	Formaldehyde	178-186	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	117-120
29889250-2	2018	Methods: Immunohistochemistry for mismatch repair proteins (MLH1, MSH2, MSH6 and PMS2) was performed in formalin-fixed paraffin-embedded sections prepared from resected primary epithelial ovarian cancers in patients who underwent oophorectomy at our institution between April 2005 and September 2014.	Formaldehyde	104-112	PMS1 homolog 2, mismatch repair system component	Homo sapiens	81-85
30087576-2	2018	The present study was designed to evaluate a chip-based digital PCR (dPCR) system for assessing HER2 amplification from formalin-fixed paraffin-embedded breast carcinoma tissue and to compare this system with immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH).	Formaldehyde	120-128	erb-b2 receptor tyrosine kinase 2	Homo sapiens	96-100
30087576-6	2018	Conclusion: These results demonstrate that chip-based dPCR is suitable for HER2 amplification detection in formalin-fixed paraffin-embedded samples in a clinical setting, providing the advantages of superior turnaround time, cost-effectiveness, and increased precision with absolute quantification compared with conventional tests such as FISH and IHC.	Formaldehyde	107-115	erb-b2 receptor tyrosine kinase 2	Homo sapiens	75-79
29758384-7	2018	The siRNA-mediated knockdown of SHP1 or interference with SHP1/GluN2A interaction by a synthetic peptide alleviated inflammatory pain induced by either Complete Freund"s Adjuvant or formalin.	Formaldehyde	182-190	protein tyrosine phosphatase, non-receptor type 6	Rattus norvegicus	32-36
29758384-7	2018	The siRNA-mediated knockdown of SHP1 or interference with SHP1/GluN2A interaction by a synthetic peptide alleviated inflammatory pain induced by either Complete Freund"s Adjuvant or formalin.	Formaldehyde	182-190	protein tyrosine phosphatase, non-receptor type 6	Rattus norvegicus	58-62
29758384-7	2018	The siRNA-mediated knockdown of SHP1 or interference with SHP1/GluN2A interaction by a synthetic peptide alleviated inflammatory pain induced by either Complete Freund"s Adjuvant or formalin.	Formaldehyde	182-190	glutamate ionotropic receptor NMDA type subunit 2A	Rattus norvegicus	63-69
29773191-12	2018	Moreover, DPD attenuated the increase in iNOS, NF-kappaB and JNK phosphorylation in the spinal cord of mice injected with formalin.	Formaldehyde	122-130	nitric oxide synthase 2, inducible	Mus musculus	41-45
29535130-4	2018	Quantitative p95 protein expression was measured in formalin-fixed paraffin-embedded samples using the p95 VeraTag assay (Monogram Biosciences), specific for the M611 form of p95.	Formaldehyde	52-60	nibrin	Homo sapiens	13-16
29401634-3	2018	Here, we report that patients with T2DM and mutations in the formaldehyde (FA)-degrading enzyme aldehyde dehydrogenase 2 ( ALDH2) gene had higher levels of FA and more severe dementia.	Formaldehyde	61-73	aldehyde dehydrogenase 2 family member	Homo sapiens	96-120
29401634-3	2018	Here, we report that patients with T2DM and mutations in the formaldehyde (FA)-degrading enzyme aldehyde dehydrogenase 2 ( ALDH2) gene had higher levels of FA and more severe dementia.	Formaldehyde	61-73	aldehyde dehydrogenase 2 family member	Homo sapiens	123-128
29936451-5	2018	HuR immunoreactivity was evaluated immunohistochemically in formalin-fixed specimens.	Formaldehyde	60-68	ELAV like RNA binding protein 1	Homo sapiens	0-3
30004048-3	2018	Methods: HE4 expressions were studied in 242 formalin-fixed, paraffin-embedded breast carcinoma specimens and their association with different pathological and clinical parameters was evaluated.	Formaldehyde	45-53	WAP four-disulfide core domain 2	Homo sapiens	9-12
33626829-0	2018	Real-Time PCR to Detect alpha-1 Antitrypsin S and Z Alleles in Formalin-Fixed Paraffin-Embedded Tissue.	Formaldehyde	63-71	serpin family A member 1	Homo sapiens	24-43
29773191-12	2018	Moreover, DPD attenuated the increase in iNOS, NF-kappaB and JNK phosphorylation in the spinal cord of mice injected with formalin.	Formaldehyde	122-130	mitogen-activated protein kinase 8	Mus musculus	61-64
30431717-4	2018	The expression of NEDD9 was analyzed immunohistochemically in 71 formalin-fixed and paraffin-embedded transbronchial biopsy specimens of primary lung adenocarcinoma.	Formaldehyde	65-73	neural precursor cell expressed, developmentally down-regulated 9	Homo sapiens	18-23
29750309-5	2018	Immunohistochemistry analyses conducted on formalin-fixed paraffin-embedded breast cancer tissue sections revealed that Ran expression was associated with tumor histological grade, nerve invasion and metastasis, vascular metastasis and Ki-67 expression (a marker of cell proliferation).	Formaldehyde	43-51	RAN, member RAS oncogene family	Homo sapiens	120-123
29937513-9	2018	Sanger sequencing of KIT in additional 15 Formalin Fixed Paraffin Embedded (FFPE) EMC did not show any other mutated cases.	Formaldehyde	42-50	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	21-24
29767258-3	2018	PD-L1 mRNA expression of formalin-fixed paraffin-embedded paratumoral and intratumoral tissues was quantified by PCR.	Formaldehyde	25-33	CD274 molecule	Homo sapiens	0-5
29758289-5	2018	The results showed that exposure to 1.0 mg/m3 formaldehyde or 20 mg/kg d DINP slightly aggravated the airway wall remodeling, promoted the production of IgE and IgG1, and induced the occurrence of airway hyperresponsiveness (AHR).	Formaldehyde	46-58	LOC105243590	Mus musculus	161-165
29853535-7	2018	Galectin-3 expression in formalin-fixed paraffin-embedded lung tissue sections was demonstrated by using the immunohistochemistry methods.	Formaldehyde	25-33	galectin 3	Rattus norvegicus	0-10
29879227-9	2018	Although these DNA samples contain low overall yield of amplifiable DNA, our newly-developed assay successfully revealed BRAF V600 mutations in 6 of 93 formalin-fixed paraffin-embedded colorectal cancer tissues which KRAS mutation was not detected.	Formaldehyde	152-160	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	121-125
29689598-3	2018	In this study, we analyzed the presence of PIK3CA mutations in formalin-fixed, paraffin-embedded, metastatic tissue and corresponding ctDNA from serum of patients with advanced breast cancer using a highly sensitive, optimized droplet digital PCR (ddPCR) assay.	Formaldehyde	63-71	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	43-49
28079349-4	2018	METHODS: mRNA expression of IL13Ralpha2 was measured using real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR) in 52 formalin-fixed paraffin-embedded glioma samples (4 pilocytic astrocytomas, 9 diffuse astrocytomas, 12 anaplastic astrocytomas, and 27 glioblastomas, grade IV).	Formaldehyde	146-154	interleukin 13 receptor subunit alpha 2	Homo sapiens	28-39
29659668-10	2018	The fixative methods did not affect the immunostaining, with overall PD-L1 high expression (TPS >=50%) rates of 42% in formalin-fixed specimens versus 40% in specimens with combined fixation by methanol/alcohol and formalin (NS).	Formaldehyde	119-127	CD274 antigen	Mus musculus	69-74
29661737-1	2018	Prolonged time from specimen excision to adequate formalin exposure, or cold ischemic time (CIT), negatively impacts estrogen receptor (ER), progesterone receptor (PR) and HER-2 biomarker studies routinely performed on breast specimens.	Formaldehyde	50-58	estrogen receptor 1	Homo sapiens	117-134
29661737-1	2018	Prolonged time from specimen excision to adequate formalin exposure, or cold ischemic time (CIT), negatively impacts estrogen receptor (ER), progesterone receptor (PR) and HER-2 biomarker studies routinely performed on breast specimens.	Formaldehyde	50-58	estrogen receptor 1	Homo sapiens	136-138
29661737-1	2018	Prolonged time from specimen excision to adequate formalin exposure, or cold ischemic time (CIT), negatively impacts estrogen receptor (ER), progesterone receptor (PR) and HER-2 biomarker studies routinely performed on breast specimens.	Formaldehyde	50-58	erb-b2 receptor tyrosine kinase 2	Homo sapiens	172-177
29462571-3	2018	Herein, we describe a novel multiplexed in situ hybridization (ISH) (RNAscope) protocol to detect HIV-DNA (vDNA) and HIV-RNA (vRNA) in formalin-fixed paraffin-embedded (FFPE) human tissues in combination with immunofluorescence (IF) phenotyping of the infected cells.	Formaldehyde	135-143	vault RNA 1-1	Homo sapiens	126-130
29344904-8	2018	RESULTS: In the first 12 h after adenoma removal, tissue samples remained MGMT positive in significantly more samples when fixated with formaldehyde than with RCL2, respectively (96 vs. 81%, p = 0.025).	Formaldehyde	136-148	O-6-methylguanine-DNA methyltransferase	Homo sapiens	74-78
29344904-9	2018	CONCLUSION: Our data confirm that the current method using formaldehyde tissue fixation and IHC reveals stable and reliable results of MGMT assessment in pituitary adenomas.	Formaldehyde	59-71	O-6-methylguanine-DNA methyltransferase	Homo sapiens	135-139
30003101-10	2018	Cotreatment with formaldehyde and doxorubicin also showed increased toxicity in anthracycline-resistant strains siz1 and msh2.	Formaldehyde	17-29	SUMO ligase SIZ1	Saccharomyces cerevisiae S288C	112-116
29602637-5	2018	Expression of importin-11 was detected in 134 formalin-fixed and paraffin-embedded (FFPE) BCa tissues and 10 paired nonneoplastic bladder tissue specimens by immunohistochemistry.	Formaldehyde	46-54	importin 11	Homo sapiens	14-25
29857823-3	2018	Immunohistochemical analysis was performed to evaluate PAX2 protein expression in 36 TAM-R and 36 TAM-S formalin-fixed paraffin-embedded (FFPE) breast tumor tissues.	Formaldehyde	104-112	paired box 2	Homo sapiens	55-59
30003101-10	2018	Cotreatment with formaldehyde and doxorubicin also showed increased toxicity in anthracycline-resistant strains siz1 and msh2.	Formaldehyde	17-29	mismatch repair ATPase MSH2	Saccharomyces cerevisiae S288C	121-125
29847797-6	2018	Intrathecal AIBP reverses established allodynia in mice in which pain states were induced by the chemotherapeutic cisplatin, intraplantar formalin, or intrathecal LPS, all of which are pro-nociceptive interventions known to be regulated by TLR4 signaling.	Formaldehyde	138-146	NAD(P)HX epimerase	Mus musculus	12-16
29847601-5	2018	The results showed that rPDHA1, rGAPDH and formalin-killed S. iniae significantly induced the proliferation of sIg+ lymphocytes, the production of total serum IgM and specific IgM as compared with the control group, and rGAPDH and rPDHA1 provide higher RPS (62.5% and 75%, respectively) again.	Formaldehyde	43-51	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	220-226
29847601-5	2018	The results showed that rPDHA1, rGAPDH and formalin-killed S. iniae significantly induced the proliferation of sIg+ lymphocytes, the production of total serum IgM and specific IgM as compared with the control group, and rGAPDH and rPDHA1 provide higher RPS (62.5% and 75%, respectively) again.	Formaldehyde	43-51	pyruvate dehydrogenase E1 subunit alpha 1	Rattus norvegicus	231-237
29930915-11	2018	As P2Y2R is prone to upregulation under conditions of inflammation, we compared the expression level of P2Y2R in formalin fixed tissues of HCPS decedents using a TaqMan assay and immunohistochemistry.	Formaldehyde	113-121	purinergic receptor P2Y2	Homo sapiens	104-109
29872371-0	2018	Commentary on New Formaldehyde Studies in Trp53 Haploinsufficient Mice: Further Support for Nonlinear Risks From Inhaled Formaldehyde.	Formaldehyde	18-30	transformation related protein 53	Mus musculus	42-47
29683668-5	2018	By using quantum chemical calculations at the MP2/6-311++G** level, we predict the geometry, electronic structural parameters, binding energy, and spectral shift of H-bonded complexes between CDCl3 and two series of compounds named RCOR" (H2CO, CH3HCO, (CH3)2CO, and C2H5(CH3)CO) and RSR" (H2S, CH3HS, (CH3)2S, and (C2H5)2S) series.	Formaldehyde	239-243	REST corepressor 1	Homo sapiens	232-237
29610256-2	2018	Humans and rodents both express Dectin-1 and Toll-like receptor 2 (TLR2) on myeloid cells, and those receptors collaborate to maximize the cytokine/chemokine responses to spherules (the tissue form of the fungi) and to formalin-killed spherules (FKS).	Formaldehyde	219-227	C-type lectin domain containing 7A	Homo sapiens	32-40
29610256-2	2018	Humans and rodents both express Dectin-1 and Toll-like receptor 2 (TLR2) on myeloid cells, and those receptors collaborate to maximize the cytokine/chemokine responses to spherules (the tissue form of the fungi) and to formalin-killed spherules (FKS).	Formaldehyde	219-227	toll like receptor 2	Homo sapiens	45-65
29610256-2	2018	Humans and rodents both express Dectin-1 and Toll-like receptor 2 (TLR2) on myeloid cells, and those receptors collaborate to maximize the cytokine/chemokine responses to spherules (the tissue form of the fungi) and to formalin-killed spherules (FKS).	Formaldehyde	219-227	toll like receptor 2	Homo sapiens	67-71
29235112-2	2018	In our retrospective study the expression of Hsp70 was determined in relation to tumor-infiltrating CD56+ NK cells in formalin-fixed paraffin embedded (FFPE) tumor specimens of patients with SCCHN (N = 145) as potential indicators for survival and disease recurrence.	Formaldehyde	118-126	heat shock protein family A (Hsp70) member 4	Homo sapiens	45-50
29485712-10	2018	Finally, TRPM8 blockage resulted in a significant antinociceptive effect in formalin-induced orofacial pain and in chronic constriction injury-induced neuropathic pain, confirming an important role for this channel in pain perception.	Formaldehyde	76-84	transient receptor potential cation channel, subfamily M, member 8	Rattus norvegicus	9-14
29380463-3	2018	Fluorescence in situ hybridization analysis of the A20 gene was performed using archived formalin-fixed tissues in 49 cases of NKTL.	Formaldehyde	89-97	TNF alpha induced protein 3	Homo sapiens	51-54
29297092-6	2018	Expression of COX-2 was studied by immunohistochemistry of formalin-fixed paraffin-embedded tissue samples of 20 melanomas.	Formaldehyde	59-67	prostaglandin-endoperoxide synthase 2	Homo sapiens	14-19
29169286-5	2018	Reverse transcription-polymerase chain reaction analysis using a formalin-fixed, paraffin-embedded tumor tissue specimen revealed the CRTC1-MAML2 fusion gene transcript.	Formaldehyde	65-73	CREB regulated transcription coactivator 1	Homo sapiens	134-139
31938367-1	2018	The aim of this study was to elaborate the correlation between metastasis-associated protein (MTA) family and the occurrence, progression, prognosis and chemotherapy efficiency in nasopharyngeal carcinoma (NPC).The expression of MTA1, MTA2 and MTA3 protein were detected by immunohistochemistry in a tissue microarray (TMAs) which contains tissue samples of 152 NPC patients embedded by formalin-fixed paraffin.	Formaldehyde	387-395	LY6/PLAUR domain containing 5	Homo sapiens	63-92
31938367-1	2018	The aim of this study was to elaborate the correlation between metastasis-associated protein (MTA) family and the occurrence, progression, prognosis and chemotherapy efficiency in nasopharyngeal carcinoma (NPC).The expression of MTA1, MTA2 and MTA3 protein were detected by immunohistochemistry in a tissue microarray (TMAs) which contains tissue samples of 152 NPC patients embedded by formalin-fixed paraffin.	Formaldehyde	387-395	LY6/PLAUR domain containing 5	Homo sapiens	94-97
29169286-5	2018	Reverse transcription-polymerase chain reaction analysis using a formalin-fixed, paraffin-embedded tumor tissue specimen revealed the CRTC1-MAML2 fusion gene transcript.	Formaldehyde	65-73	mastermind like transcriptional coactivator 2	Homo sapiens	140-145
29716990-5	2018	We developed the formaldehyde cross-linking and immunoprecipitation method to identify ECT2-RNA interaction sites at the transcriptome-wide level.	Formaldehyde	17-29	evolutionarily conserved C-terminal region 2	Arabidopsis thaliana	87-91
29453630-12	2018	Formalin-fixed paraffin-embedded cancer tissue can undergo testing within a routine molecular-diagnostic setting as a clinical BRCA1/2 mutation screening strategy.	Formaldehyde	0-8	BRCA1 DNA repair associated	Homo sapiens	127-134
29327716-3	2018	Clinically, targeted anti-ALK therapy is often initiated based on evidence of an ALK genomic rearrangement detected by fluorescence in situ hybridization (FISH) of interphase cells in formalin-fixed, paraffin-embedded tissue sections.	Formaldehyde	184-192	ALK receptor tyrosine kinase	Homo sapiens	26-29
29327716-3	2018	Clinically, targeted anti-ALK therapy is often initiated based on evidence of an ALK genomic rearrangement detected by fluorescence in situ hybridization (FISH) of interphase cells in formalin-fixed, paraffin-embedded tissue sections.	Formaldehyde	184-192	ALK receptor tyrosine kinase	Homo sapiens	81-84
29713584-2	2018	PD-L1 immunohistochemical testing is approved for formalin-fixed, paraffin-embedded (FFPE) surgical pathology specimens; however, the testing performance on FFPE cytology cell block specimens is unknown.	Formaldehyde	50-58	CD274 molecule	Homo sapiens	0-5
29707109-4	2018	Methods: PDCD4 nuclear expression was assessed by immunohistochemistry (IHC) in 40 non-neoplastic pleural (NNP) and 40 MPM formalin-fixed and paraffin-embedded specimens.	Formaldehyde	123-131	programmed cell death 4	Homo sapiens	9-14
29719408-4	2018	Methods: The expression levels of DGCR9 in each patient between formalin-fixed, paraffin-embedded (FFPE) gastric cancer tissues and adjacent noncancer tissues (NAT) (n=102) were measured by quantitative reverse-transcription polymerase chain reaction (qRT-PCR).	Formaldehyde	64-72	DiGeorge syndrome critical region gene 9	Homo sapiens	34-39
29617441-4	2018	Expressions of PD-1 and PD-L1 were detected immunohistochemically in 25 formalin-fixed, paraffin-embedded tumor specimens from 24 patients with intracranial germinoma consisting of 22 primary and 3 recurrent tumors.	Formaldehyde	72-80	programmed cell death 1	Homo sapiens	15-19
29707138-4	2018	RNF2 was detected immunohistochemically in standard formalin-fixed paraffin-embedded samples of 9 benign nevi, 60 melanomas and 24 nodal metastases.	Formaldehyde	52-60	ring finger protein 2	Homo sapiens	0-4
29343200-2	2018	This study examined CD31 immunoreactivity of 347 formalin-fixed, paraffin-embedded normal, nonneoplastic, and neoplastic canine tissues.	Formaldehyde	49-57	platelet and endothelial cell adhesion molecule 1	Homo sapiens	20-24
29567033-7	2018	Then, the vaccine potential of rIDH was tested in a flounder model, and the results showed that rIDH produced a relative percent survival (RPS) of 73.3%, which was significantly higher than that produced by formalin killed E. tarda cells.	Formaldehyde	207-215	isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma	Rattus norvegicus	31-35
29650024-7	2018	Moreover, approximately 34.0% of the collateral projection neurons in the Vc showed Fos immunopositivity after injection of formalin into the lip, and parts of calcitonin gene-related peptide (CGRP)-immunopositive axonal varicosities were in direct contact with the Vc collateral projection neurons.	Formaldehyde	124-132	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	84-87
29631612-8	2018	Expression status of TRIM28 in tumor epithelium and stromal fibroblasts was assessed using IHC in formalin fixed tissue and the epithelium to stroma protein expression ratio method.	Formaldehyde	98-106	tripartite motif containing 28	Homo sapiens	21-27
28949407-8	2018	The formalin test (formalin 2.5%) was performed following the administration of spexin and progesterone.	Formaldehyde	4-12	spexin hormone	Rattus norvegicus	80-86
29394316-8	2018	Following formalin inflammation or neuropathy with a modified Chung model, we observed normal development of acute pain behaviour, but a deficit in second phase formalin-induced nocifensive responses and a reversal of neuropathy-induced mechanical hypersensitivity during the later chronic pain phase in conditional BDNF knockout mice.	Formaldehyde	10-18	brain derived neurotrophic factor	Mus musculus	316-320
28949407-9	2018	Results showed that bilateral injection of spexin in IHCA3 at both concentrations a significant (P &lt; .05) decrease in the pain sensitivity in the two phases of formalin test.	Formaldehyde	163-171	spexin hormone	Rattus norvegicus	43-49
28949407-10	2018	Similarly, the bilateral injection of spexin in IHCA3 at both concentrations following the s.c. injection of progesterone significantly (P &lt; .05) decreases pain sensitivity in two phases of the formalin test.	Formaldehyde	197-205	spexin hormone	Rattus norvegicus	38-44
29796223-8	2018	Results: ICV injection of CGRP lead to a significant pain reduction in acute, middle and chronic phases of the formalin test.	Formaldehyde	111-119	calcitonin-related polypeptide alpha	Rattus norvegicus	26-30
29104286-7	2018	Semiquantitative immunofluorescence and confocal imaging were used to assess ASC-specific protein expression in formalin-fixed paraffin-embedded tissue sections of breast of women and mammary tissue of mice following a low-fat (LF) or high-fat (HF) diet for 17 weeks.	Formaldehyde	112-120	PYD and CARD domain containing	Homo sapiens	77-80
29642180-3	2018	The protein expression of CSTA was evaluated by the immunostaining of formalin-fixed, paraffin-embedded sections of ESCC samples from 59 patients who underwent surgery, and its relationship with clinical features was analyzed.The mRNA expression of CSTA was significantly decreased in ESCC compared with that in matched normal mucosa (P &lt; .0001).	Formaldehyde	70-78	cystatin A	Homo sapiens	26-30
29442983-0	2018	Formaldehyde Treatment Using Overexpressed Aldehyde Dehydrogenase 6 from Recombinant Saccharomyces cerevisiae.	Formaldehyde	0-12	aldehyde dehydrogenase (NADP(+)) ALD6	Saccharomyces cerevisiae S288C	43-67
29442983-4	2018	In this study, we designed a method for using aldehyde dehydrogenase 6 (ALD6) from recombinant Saccharomyces cerevisiae to reduce formaldehyde.	Formaldehyde	130-142	aldehyde dehydrogenase (NADP(+)) ALD6	Saccharomyces cerevisiae S288C	46-70
29442983-4	2018	In this study, we designed a method for using aldehyde dehydrogenase 6 (ALD6) from recombinant Saccharomyces cerevisiae to reduce formaldehyde.	Formaldehyde	130-142	aldehyde dehydrogenase (NADP(+)) ALD6	Saccharomyces cerevisiae S288C	72-76
29442983-10	2018	Formaldehyde levels were lowest in enzymes from cells overexpressing ALD6.	Formaldehyde	0-12	aldehyde dehydrogenase (NADP(+)) ALD6	Saccharomyces cerevisiae S288C	69-73
29442983-11	2018	Furthermore, when the strains were exposed to formaldehyde stress, NADH levels increased for strains overexpressing ALD6 and decreased for dominant negative strains.	Formaldehyde	46-58	aldehyde dehydrogenase (NADP(+)) ALD6	Saccharomyces cerevisiae S288C	116-120
29442983-12	2018	Therefore, our results suggest that ALD6 plays a key role in formaldehyde treatment.	Formaldehyde	61-73	aldehyde dehydrogenase (NADP(+)) ALD6	Saccharomyces cerevisiae S288C	36-40
29442983-13	2018	We expect that ALD6 could be used in applications related to the removal of formaldehyde.	Formaldehyde	76-88	aldehyde dehydrogenase (NADP(+)) ALD6	Saccharomyces cerevisiae S288C	15-19
29520890-12	2018	We show that apical NHERF1 IHC intensity is inversely associated with multipolar spindle frequency and high-grade morphology in formalin-fixed human CRC samples.	Formaldehyde	128-136	SLC9A3 regulator 1	Homo sapiens	20-26
29577038-4	2018	An explanted PSC liver from a 60-year-old male who suffered from recurrent cholangitis was formalin-fixed, paraffin-embedded and Gram stained.	Formaldehyde	91-99	PSC	Homo sapiens	13-16
29393455-4	2018	EphA1 protein was detected in ovarian cancer cell lines and in a set of formalin-fixed tissues, including normal fallopian tube, ovarian benign serous cystadenoma, borderline serous tumors and serous carcinoma.	Formaldehyde	72-80	EPH receptor A1	Homo sapiens	0-5
29366515-18	2018	pretreatment with oxyntomodulin attenuated formalin-induced increase of phosphorlated ERK (p-ERK) expression in the spinal cord.	Formaldehyde	43-51	mitogen-activated protein kinase 1	Mus musculus	86-89
29366515-18	2018	pretreatment with oxyntomodulin attenuated formalin-induced increase of phosphorlated ERK (p-ERK) expression in the spinal cord.	Formaldehyde	43-51	mitogen-activated protein kinase 1	Mus musculus	93-96
29366515-21	2018	Furthermore, the antinociception induced by oxyntomodulin appears to be mediated by reduced formalin-induced p-ERK expression in the spinal cord.	Formaldehyde	92-100	mitogen-activated protein kinase 1	Mus musculus	111-114
29351917-4	2018	The EpiWNT-SHH classifier showed high prediction capacity using both frozen and formalin-fixed material, as well as diverse DNA methylation detection methods.	Formaldehyde	80-88	sonic hedgehog signaling molecule	Homo sapiens	11-14
29623029-5	2018	Inhibiting the p38 phosphorylation in PL reversed the aggravated nociceptive responses to formalin test and down-regulated enhanced phosphorylated CREB in the PL.	Formaldehyde	90-98	mitogen activated protein kinase 14	Rattus norvegicus	15-18
29568219-0	2018	Technical Validation of a Reverse-Transcription Quantitative Polymerase Chain Reaction In Vitro Diagnostic Test for the Determination of MiR-31-3p Expression Levels in Formalin-Fixed Paraffin-Embedded Metastatic Colorectal Cancer Tumor Specimens.	Formaldehyde	168-176	microRNA 31	Homo sapiens	137-143
29534467-0	2018	Expanding the Utilization of Formalin-Fixed, Paraffin-Embedded Archives: Feasibility of miR-Seq for Disease Exploration and Biomarker Development from Biopsies with Clear Cell Renal Cell Carcinoma.	Formaldehyde	29-37	membrane associated ring-CH-type finger 8	Homo sapiens	88-91
29540771-3	2018	Our results showed that nitrogen insoluble in cold or hot water from urea-formaldehyde fertilizers were mainly affected by urea: formaldehyde molar ratios.	Formaldehyde	74-86	alcohol dehydrogenase iron containing 1	Homo sapiens	54-57
29540771-3	2018	Our results showed that nitrogen insoluble in cold or hot water from urea-formaldehyde fertilizers were mainly affected by urea: formaldehyde molar ratios.	Formaldehyde	129-141	alcohol dehydrogenase iron containing 1	Homo sapiens	54-57
29540771-5	2018	According to the models, the optimal process parameters which maximize cold-water-insoluble nitrogen and minimize hot-water-insoluble nitrogen for the synthesis of urea formaldehyde were as follows urea: formaldehyde molar ratio was 1.33, reaction temperature was 43.5  C, and reaction time was 1.64 h. Under these conditions, the content of cold-water-insoluble nitrogen was 22.14%, and hot-water-insoluble nitrogen was 9.87%.	Formaldehyde	169-181	alcohol dehydrogenase iron containing 1	Homo sapiens	114-117
29540771-5	2018	According to the models, the optimal process parameters which maximize cold-water-insoluble nitrogen and minimize hot-water-insoluble nitrogen for the synthesis of urea formaldehyde were as follows urea: formaldehyde molar ratio was 1.33, reaction temperature was 43.5  C, and reaction time was 1.64 h. Under these conditions, the content of cold-water-insoluble nitrogen was 22.14%, and hot-water-insoluble nitrogen was 9.87%.	Formaldehyde	169-181	alcohol dehydrogenase iron containing 1	Homo sapiens	388-391
29540771-5	2018	According to the models, the optimal process parameters which maximize cold-water-insoluble nitrogen and minimize hot-water-insoluble nitrogen for the synthesis of urea formaldehyde were as follows urea: formaldehyde molar ratio was 1.33, reaction temperature was 43.5  C, and reaction time was 1.64 h. Under these conditions, the content of cold-water-insoluble nitrogen was 22.14%, and hot-water-insoluble nitrogen was 9.87%.	Formaldehyde	204-216	alcohol dehydrogenase iron containing 1	Homo sapiens	114-117
29517684-4	2018	In this paper, we investigated the expression of CXCL14 and NOS1 in specimens from patients with stage I-IIIA nonsmall cell lung cancer (NSCLC) after curative resection, and evaluated the prognostic significance of this gene expression in stromal fibroblasts and cancer cells.Immunohistochemistry was used to detect the expression of CXCL14 and NOS1 in 106 formalin fixed, paraffin-embedded specimens from patients with stage I-IIIA NSCLC.	Formaldehyde	357-365	C-X-C motif chemokine ligand 14	Homo sapiens	49-55
29471352-1	2018	Objectives: The gold standard of examining breast biomarkers, including estrogen receptor (ER)/progesterone receptor (PR)/human epidermal growth factor receptor 2 (HER2)/Ki-67, is to perform these assays on formalin-fixed, paraffin-embedded tissue.	Formaldehyde	207-215	progesterone receptor	Homo sapiens	95-116
29471352-1	2018	Objectives: The gold standard of examining breast biomarkers, including estrogen receptor (ER)/progesterone receptor (PR)/human epidermal growth factor receptor 2 (HER2)/Ki-67, is to perform these assays on formalin-fixed, paraffin-embedded tissue.	Formaldehyde	207-215	erb-b2 receptor tyrosine kinase 2	Homo sapiens	128-162
27362474-0	2018	Immunoreactivity of a Monoclonal Antibody to SS18-SSX Fusion Gene Product in Formalin-fixed Paraffin-embedded Synovial Sarcoma Tissue Section.	Formaldehyde	77-85	SS18 subunit of BAF chromatin remodeling complex	Homo sapiens	45-49
27362474-0	2018	Immunoreactivity of a Monoclonal Antibody to SS18-SSX Fusion Gene Product in Formalin-fixed Paraffin-embedded Synovial Sarcoma Tissue Section.	Formaldehyde	77-85	SSX family member 2B	Homo sapiens	50-53
27389555-1	2018	BACKGROUND: Growth factor receptor HER3 (ErbB3) lacks standardized immunohistochemistry (IHC)-based methods for formalin-fixed paraffin-embedded (FFPE) tissue samples.	Formaldehyde	112-120	erb-b2 receptor tyrosine kinase 3	Homo sapiens	35-39
27389555-1	2018	BACKGROUND: Growth factor receptor HER3 (ErbB3) lacks standardized immunohistochemistry (IHC)-based methods for formalin-fixed paraffin-embedded (FFPE) tissue samples.	Formaldehyde	112-120	erb-b2 receptor tyrosine kinase 3	Homo sapiens	41-46
29293100-4	2018	The polysialylated isoform of NCAM was evaluated on formalin-fixed and paraffin-embedded tissues.	Formaldehyde	52-60	neural cell adhesion molecule 1	Homo sapiens	30-34
29353374-1	2018	The mechanistic target of rapamycin (mTOR) has been demonstrated to mediate pain-related aversion induced by formalin in the rostral anterior cingulate cortex (rACC).	Formaldehyde	109-117	mechanistic target of rapamycin kinase	Rattus norvegicus	4-35
29353374-1	2018	The mechanistic target of rapamycin (mTOR) has been demonstrated to mediate pain-related aversion induced by formalin in the rostral anterior cingulate cortex (rACC).	Formaldehyde	109-117	mechanistic target of rapamycin kinase	Rattus norvegicus	37-41
29353374-4	2018	In this study, we used a rat formalin-induced inflammatory pain model to demonstrate BDNF up-regulation in the rACC.	Formaldehyde	29-37	brain-derived neurotrophic factor	Rattus norvegicus	85-89
29467863-15	2018	CastPCR technology is a robust method with high sensitivity for the molecular detection of EGFR and BRAF mutations in clinical formalin-fixed paraffin-embedded samples.	Formaldehyde	127-135	epidermal growth factor receptor	Homo sapiens	91-95
29467863-15	2018	CastPCR technology is a robust method with high sensitivity for the molecular detection of EGFR and BRAF mutations in clinical formalin-fixed paraffin-embedded samples.	Formaldehyde	127-135	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	100-104
29435030-5	2018	FAK expression was investigated in 100 formalin-fixed, paraffin-embedded human thymic epithelial tumor (TET) specimens using immunohistochemical analysis with FAK-specific monoclonal antibody 4.47, and the associations between FAK expression and clinicopathological parameters (including sex, age, tumor size, myasthenia gravis, World Health Organization classification and Masaoka-Koga stage) were analyzed.	Formaldehyde	39-47	protein tyrosine kinase 2	Homo sapiens	0-3
29289721-0	2018	Spinal Sigma-1 Receptor-mediated Dephosphorylation of Astrocytic Aromatase Plays a Key Role in Formalin-induced Inflammatory Nociception.	Formaldehyde	95-103	sigma non-opioid intracellular receptor 1	Mus musculus	7-23
29496041-4	2018	Formalin-fixed, paraffin-embedded cancer tissues were subjected to histopathological evaluation, DNA quality control, HPV-DNA detection, and p16INK4a/pRb/p53/Cyclin-D1 immunohistochemistry.	Formaldehyde	0-8	cyclin dependent kinase inhibitor 2A	Homo sapiens	141-149
29496041-4	2018	Formalin-fixed, paraffin-embedded cancer tissues were subjected to histopathological evaluation, DNA quality control, HPV-DNA detection, and p16INK4a/pRb/p53/Cyclin-D1 immunohistochemistry.	Formaldehyde	0-8	RB transcriptional corepressor 1	Homo sapiens	150-153
29496041-4	2018	Formalin-fixed, paraffin-embedded cancer tissues were subjected to histopathological evaluation, DNA quality control, HPV-DNA detection, and p16INK4a/pRb/p53/Cyclin-D1 immunohistochemistry.	Formaldehyde	0-8	tumor protein p53	Homo sapiens	154-157
29496041-4	2018	Formalin-fixed, paraffin-embedded cancer tissues were subjected to histopathological evaluation, DNA quality control, HPV-DNA detection, and p16INK4a/pRb/p53/Cyclin-D1 immunohistochemistry.	Formaldehyde	0-8	cyclin D1	Homo sapiens	158-167
29134440-3	2018	Systematic assessment of the proliferative activity of tumors using Ki67 started in the 1990s, when Ki67, which only worked on frozen tissue, was complemented by the antibody MIB-1 that also worked in formalin-fixed tissues.	Formaldehyde	201-209	MIB E3 ubiquitin protein ligase 1	Homo sapiens	175-180
29289721-11	2018	administration of a sub-effective dose of BD1047 potentiated the pharmacological effect of cyclosporin A (a calcineurin inhibitor) on both the formalin-induced reduction in phospho-serine levels of aromatase and nociceptive behavior.	Formaldehyde	143-151	cytochrome P450, family 19, subfamily a, polypeptide 1	Mus musculus	198-207
29289721-0	2018	Spinal Sigma-1 Receptor-mediated Dephosphorylation of Astrocytic Aromatase Plays a Key Role in Formalin-induced Inflammatory Nociception.	Formaldehyde	95-103	cytochrome P450, family 19, subfamily a, polypeptide 1	Mus musculus	65-74
29289721-3	2018	The present study focuses on the potential role of astrocyte aromatase in formalin-induced acute pain and begins to uncover one mechanism by which spinal aromatase activation is controlled.	Formaldehyde	74-82	cytochrome P450, family 19, subfamily a, polypeptide 1	Mus musculus	61-70
29289721-3	2018	The present study focuses on the potential role of astrocyte aromatase in formalin-induced acute pain and begins to uncover one mechanism by which spinal aromatase activation is controlled.	Formaldehyde	74-82	cytochrome P450, family 19, subfamily a, polypeptide 1	Mus musculus	154-163
29289721-6	2018	injection of letrozole (an aromatase inhibitor) mitigated both the late phase formalin-induced nociceptive responses and formalin-induced spinal Fos expression.	Formaldehyde	78-86	cytochrome P450, family 19, subfamily a, polypeptide 1	Mus musculus	27-36
29289721-6	2018	injection of letrozole (an aromatase inhibitor) mitigated both the late phase formalin-induced nociceptive responses and formalin-induced spinal Fos expression.	Formaldehyde	121-129	cytochrome P450, family 19, subfamily a, polypeptide 1	Mus musculus	27-36
29289721-6	2018	injection of letrozole (an aromatase inhibitor) mitigated both the late phase formalin-induced nociceptive responses and formalin-induced spinal Fos expression.	Formaldehyde	121-129	FBJ osteosarcoma oncogene	Mus musculus	145-148
29289721-7	2018	Furthermore, formalin-injected mice showed significantly reduced phospho-serine levels of aromatase, which is associated with the rapid activation of this enzyme.	Formaldehyde	13-21	cytochrome P450, family 19, subfamily a, polypeptide 1	Mus musculus	90-99
28719380-2	2018	Preliminary data suggest that its detection using immunohistochemistry (IHC) in formalin-fixed and paraffin-embedded tissues may predict clinical response to PD-1/PD-L1 therapy.	Formaldehyde	80-88	CD274 molecule	Homo sapiens	163-168
29229558-10	2018	THIP also suppressed the synaptic accumulation and phosphorylation of NMDA receptor GluN1 subunit in formalin-injected rats.	Formaldehyde	101-109	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	84-89
29394946-3	2018	Real-time reverse transcription quantitative polymerase chain reaction was used to evaluate the expression of miR-198-5p in 23 formalin-fixed, paraffin-embedded (FFPE) LUSC tissues and corresponding non-cancerous tissues.	Formaldehyde	127-135	microRNA 198	Homo sapiens	110-117
28915384-7	2018	This phenomenon was applied for the successful detection of formaldehyde using NAD+ dependent formaldehyde dehydrogenase.	Formaldehyde	60-72	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	94-120
31194055-10	2018	These results suggest that the antinociceptive effect of paracetamol can be enhanced mainly by compounds having 5-HT1A antagonist properties in the formalin test and maybe by 5-HT1B receptors antagonists.	Formaldehyde	148-156	5-hydroxytryptamine receptor 1A	Rattus norvegicus	112-118
29274880-4	2018	In contrast, in post-operative pain model and phase I of formalin test, intracerebroventricular administration of mouse VD-Hpalpha induced dose-related analgesia in mice, which were markedly reduced by pretreatment with the CB1 neutral antagonist AM4113, but not AM251, AM630 and the selective antagonists of opioid and Transient Receptor Potential Vanilloid Type 1 (TRPV1) receptors.	Formaldehyde	57-65	cannabinoid receptor 1 (brain)	Mus musculus	224-227
31194055-0	2018	Involvement of 5-HT1A/1B receptors in the antinociceptive effect of paracetamol in the rat formalin test.	Formaldehyde	91-99	5-hydroxytryptamine receptor 1A	Rattus norvegicus	15-21
28585113-4	2018	We found that spinal administration of minocycline or ZVEID, or Caspase6 deletion, reduced formalin-induced inflammatory and nerve injury-induced neuropathic pain primarily in male mice.	Formaldehyde	91-99	caspase 6	Mus musculus	64-72
28401489-5	2018	In contrast, both formalin-induced acute pain and complete Freund"s adjuvant-induced chronic inflammatory pain were reduced in Cxcr3 -/- mice.	Formaldehyde	18-26	chemokine (C-X-C motif) receptor 3	Mus musculus	127-132
28823399-5	2018	BAP1 expression was evaluated by immunohistochemical staining of formalin-fixed, paraffin-embedded sections.	Formaldehyde	65-73	BRCA1 associated protein 1	Homo sapiens	0-4
29434916-2	2018	In the present study, epidermal growth factor receptor (EGFR) mutations of 354 primary patients with non-small cell lung cancer (NSCLC) of Chinese ethnicity were detected following formalin-fixed and paraffin-embedded specimen DNA extraction, polymerase chain reaction amplification, and sanger sequencing.	Formaldehyde	181-189	epidermal growth factor receptor	Homo sapiens	56-60
28942315-6	2018	The results indicated that HO2 in the BB plume primarily came from formaldehyde (HCHO+hv=2HO2+CO), a secondary alkoxy radical (ROR=HO2).	Formaldehyde	67-79	heme oxygenase 2	Homo sapiens	27-30
29254792-3	2018	METHODS AND METHODS: Expression of GRK3 was detected, using tissue microarray-based immunohistochemistry, in paired formalin-fixed paraffin-embedded tumor and non-tumor samples from 165 patients with PDAC after curative resection, and was further correlated with clinicopathologic parameters and cancer-specific survival (CSS).	Formaldehyde	116-124	G protein-coupled receptor kinase 3	Homo sapiens	35-39
28988354-1	2018	MAIN CONCLUSION: Over-expression of AtFDH controlled by the promoter of Rubisco small subunit in chloroplasts increases formaldehyde uptake and metabolism in tobacco leaves.	Formaldehyde	120-132	formate dehydrogenase	Arabidopsis thaliana	36-41
31938123-4	2018	METHODS: The protein expression of Vav1 was analyzed by immunohistochemistry in formalin-fixed samples obtained from 105 GC patients.	Formaldehyde	80-88	vav guanine nucleotide exchange factor 1	Homo sapiens	35-39
29410603-6	2018	MDM2 immunohistochemical staining was performed on archival paraffin-embedded and formalin-fixed specimens (with a threshold of nuclear positivity &gt; 10%).	Formaldehyde	82-90	MDM2 proto-oncogene	Homo sapiens	0-4
29351293-3	2018	Absolute quantification of FGFR1 from formalin fixed paraffin embedded (FFPE) tissue of laryngeal SCCa was examined in this retrospective study.	Formaldehyde	38-46	fibroblast growth factor receptor 1	Homo sapiens	27-32
29386099-5	2018	Furthermore, spinal cord-specific Dcc knockout animals displayed mislocalized licking responses to formalin injection, indicating impaired topognosis.	Formaldehyde	99-107	deleted in colorectal carcinoma	Mus musculus	34-37
29229703-10	2018	Orai1 deficiency significantly decreased acute pain induced by noxious stimuli, nearly eliminated the second phase of formalin-induced nociceptive response, markedly attenuated carrageenan-induced ipsilateral pain hypersensitivity and abolished carrageenan-induced contralateral mechanical allodynia.	Formaldehyde	118-126	ORAI calcium release-activated calcium modulator 1	Homo sapiens	0-5
29229703-18	2018	Genetic knock-out of Orai1 nearly eliminates the second phase of formalin-induced pain and markedly attenuates carrageenan-induced pain hypersensitivity and neuronal excitability.	Formaldehyde	65-73	ORAI calcium release-activated calcium modulator 1	Homo sapiens	21-26
29189265-4	2018	We report validation of PD-L1 IHC 28-8 pharmDx for PD-L1 detection on formalin-fixed, paraffin-embedded human melanoma specimens using Autostainer Link 48.	Formaldehyde	70-78	CD274 molecule	Homo sapiens	24-29
29189265-4	2018	We report validation of PD-L1 IHC 28-8 pharmDx for PD-L1 detection on formalin-fixed, paraffin-embedded human melanoma specimens using Autostainer Link 48.	Formaldehyde	70-78	CD274 molecule	Homo sapiens	51-56
30182853-1	2018	BACKGROUND: Formaldehyde (FA) has been implicated in Alzheimer"s disease (AD) pathology as an age-related factor and as a protein cross-linker known to aggregate Amyloid-Beta (Abeta) and tau protein in vitro.	Formaldehyde	12-24	amyloid beta precursor protein	Homo sapiens	162-174
30182853-1	2018	BACKGROUND: Formaldehyde (FA) has been implicated in Alzheimer"s disease (AD) pathology as an age-related factor and as a protein cross-linker known to aggregate Amyloid-Beta (Abeta) and tau protein in vitro.	Formaldehyde	12-24	amyloid beta precursor protein	Homo sapiens	176-181
30182853-1	2018	BACKGROUND: Formaldehyde (FA) has been implicated in Alzheimer"s disease (AD) pathology as an age-related factor and as a protein cross-linker known to aggregate Amyloid-Beta (Abeta) and tau protein in vitro.	Formaldehyde	12-24	microtubule associated protein tau	Homo sapiens	187-190
31043303-1	2018	INTRODUCTION: Evaluation of programmed cell death ligand-1 (PD-L1) on formalin-fixed paraffin-embedded (FFPE) histologic specimens is required for immunotherapy with pembrolizumab in non-small cell lung carcinoma (NSCLC).	Formaldehyde	70-78	CD274 molecule	Homo sapiens	28-58
31043303-1	2018	INTRODUCTION: Evaluation of programmed cell death ligand-1 (PD-L1) on formalin-fixed paraffin-embedded (FFPE) histologic specimens is required for immunotherapy with pembrolizumab in non-small cell lung carcinoma (NSCLC).	Formaldehyde	70-78	CD274 molecule	Homo sapiens	60-65
29177668-3	2018	In order to elucidate the role of intracellular and membrane-bound Hsp70 as a potential tumor biomarker in glioblastoma multiforme, herein, we describe protocols for the staining of cytosolic Hsp70 in tumor formalin fixed paraffin-embedded (FFPE) sections using immunohistochemistry, and for plasma membrane-bound Hsp70 by multi-parametric flow cytometry using the cmHsp70.1 monoclonal antibody (mAb).	Formaldehyde	207-215	heat shock protein family A (Hsp70) member 4	Homo sapiens	192-197
29970668-4	2018	Materials and Methods: In the present study, immunohistochemical staining and ELISA were applied to examine the relative level of EGFL7 in 182 cases of hepatocellular carcinoma (HCC) formalin-fixed and paraffin-embedded tissues and 110 cases of HCC serum samples.	Formaldehyde	183-191	EGF like domain multiple 7	Homo sapiens	130-135
29177668-3	2018	In order to elucidate the role of intracellular and membrane-bound Hsp70 as a potential tumor biomarker in glioblastoma multiforme, herein, we describe protocols for the staining of cytosolic Hsp70 in tumor formalin fixed paraffin-embedded (FFPE) sections using immunohistochemistry, and for plasma membrane-bound Hsp70 by multi-parametric flow cytometry using the cmHsp70.1 monoclonal antibody (mAb).	Formaldehyde	207-215	heat shock protein family A (Hsp70) member 4	Homo sapiens	192-197
29321392-3	2018	We have already demonstrated that the intracerebroventricular administration of DHA or GW9508, a GPR40/FFAR1 agonist, suppresses formalin-induced pain behavior.	Formaldehyde	129-137	free fatty acid receptor 1	Homo sapiens	97-102
29682243-7	2018	NRAS mutation analysis was performed on paraffin embedded formalin fixed tissue of these cases by polymerase chain reaction (PCR)-sequencing method.	Formaldehyde	58-66	NRAS proto-oncogene, GTPase	Homo sapiens	0-4
30157705-9	2018	suppressed formalin-evoked inflammatory pain in rats and reduced Fos protein-like immunoreactivity in the lumbar spinal dorsal horn.	Formaldehyde	11-19	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	65-68
30270724-5	2018	Although the single-sided formalin injection caused a significant bilateral increase in c-Fos-expressing neurons in the lateral parabrachial nucleus with slight projection-side dependence, the increase in the amplitude of postsynaptic excitatory currents and the number of c-Fos-expressing neurons in the central amygdala occurred predominantly on the right side regardless of the side of the inflammation.	Formaldehyde	26-34	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	88-93
30270724-5	2018	Although the single-sided formalin injection caused a significant bilateral increase in c-Fos-expressing neurons in the lateral parabrachial nucleus with slight projection-side dependence, the increase in the amplitude of postsynaptic excitatory currents and the number of c-Fos-expressing neurons in the central amygdala occurred predominantly on the right side regardless of the side of the inflammation.	Formaldehyde	26-34	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	273-278
29255262-2	2018	We show that SELENBP1 is a methanethiol oxidase (MTO), related to the MTO in methylotrophic bacteria, that converts methanethiol to H2O2, formaldehyde, and H2S, an activity not previously known to exist in humans.	Formaldehyde	138-150	selenium binding protein 1	Homo sapiens	13-21
29321392-3	2018	We have already demonstrated that the intracerebroventricular administration of DHA or GW9508, a GPR40/FFAR1 agonist, suppresses formalin-induced pain behavior.	Formaldehyde	129-137	free fatty acid receptor 1	Homo sapiens	103-108
28829151-3	2017	OBJECTIVES: - To validate a novel anti-CD155 antibody for immunohistochemistry and develop a robust, reliable, and specific protocol for detecting CD155 expression in glioblastoma formalin-fixed, paraffin-embedded (FFPE) tissue samples.	Formaldehyde	180-188	PVR cell adhesion molecule	Homo sapiens	147-152
29343980-0	2018	Peripheral and spinal TRPA1 channels contribute to formalin-induced long-lasting mechanical hypersensitivity.	Formaldehyde	51-59	transient receptor potential cation channel subfamily A member 1	Homo sapiens	22-27
29343980-4	2018	The purpose of this study was to investigate the local peripheral and spinal participation of TRPA1 channels in formalin-induced long-lasting hypersensitivity.	Formaldehyde	112-120	transient receptor potential cation channel subfamily A member 1	Homo sapiens	94-99
29343980-5	2018	Materials and methods: Formalin (1%)-induced chronic hypersensitivity was determined by the application of von Frey filaments to ipsilateral and contralateral paws and through pharmacological testing using a selective TRPA1 blocker (A-967079).	Formaldehyde	23-31	transient receptor potential cation channel subfamily A member 1	Homo sapiens	218-223
29343980-11	2018	Finally, formalin injection increased TRPA1 protein expression in the DRG and spinal cord.	Formaldehyde	9-17	transient receptor potential cation channel subfamily A member 1	Homo sapiens	38-43
29343980-12	2018	Conclusion: Results indicate that TRPA1 expressed in the DRG and spinal cord plays a relevant role in formalin-induced long-lasting secondary nociceptive hypersensitivity.	Formaldehyde	102-110	transient receptor potential cation channel subfamily A member 1	Homo sapiens	34-39
29187477-1	2017	BACKGROUND/AIM: We previously reported the use of mass spectrometry and western blotting to identify proteins from tumour regions of formalin-fixed paraffin-embedded biopsies from 16 men who presented with apparently localized prostate cancer, and found that annexin A2 (ANXA2) appeared to be a better predictor of subsequent biochemical failure than prostate-specific antigen (PSA).	Formaldehyde	133-141	annexin A2	Homo sapiens	259-269
29187477-1	2017	BACKGROUND/AIM: We previously reported the use of mass spectrometry and western blotting to identify proteins from tumour regions of formalin-fixed paraffin-embedded biopsies from 16 men who presented with apparently localized prostate cancer, and found that annexin A2 (ANXA2) appeared to be a better predictor of subsequent biochemical failure than prostate-specific antigen (PSA).	Formaldehyde	133-141	annexin A2	Homo sapiens	271-276
29187477-1	2017	BACKGROUND/AIM: We previously reported the use of mass spectrometry and western blotting to identify proteins from tumour regions of formalin-fixed paraffin-embedded biopsies from 16 men who presented with apparently localized prostate cancer, and found that annexin A2 (ANXA2) appeared to be a better predictor of subsequent biochemical failure than prostate-specific antigen (PSA).	Formaldehyde	133-141	kallikrein related peptidase 3	Homo sapiens	351-382
29364207-0	2017	Protocol for HER2 FISH Using a Non-cross-linking, Formalin-free Tissue Fixative to Combine Advantages of Cryo-preservation and Formalin Fixation.	Formaldehyde	50-58	erb-b2 receptor tyrosine kinase 2	Homo sapiens	13-17
29364207-0	2017	Protocol for HER2 FISH Using a Non-cross-linking, Formalin-free Tissue Fixative to Combine Advantages of Cryo-preservation and Formalin Fixation.	Formaldehyde	127-135	erb-b2 receptor tyrosine kinase 2	Homo sapiens	13-17
29259341-0	2017	Impact of the G84E variant on HOXB13 gene and protein expression in formalin-fixed, paraffin-embedded prostate tumours.	Formaldehyde	68-76	homeobox B13	Homo sapiens	30-36
29016222-3	2017	We re-examined proteomics results from a number of formalin-fixed paraffin-embedded amyloid samples, which were positive for transthyretin (TTR) by immunohistochemistry and proteomics, using the UniProt human protein database modified to include TTR variants.	Formaldehyde	51-59	transthyretin	Homo sapiens	125-138
29016222-3	2017	We re-examined proteomics results from a number of formalin-fixed paraffin-embedded amyloid samples, which were positive for transthyretin (TTR) by immunohistochemistry and proteomics, using the UniProt human protein database modified to include TTR variants.	Formaldehyde	51-59	transthyretin	Homo sapiens	140-143
29016222-4	2017	The amyloidogenic variant, V122I TTR, was incorrectly identified in 26/27 wild-type and non-V122I variant samples due to its close mass spectral similarity with the methyl lysine-modified WT peptide [126KMe]105-127 (p.[146 KMe]125-147) generated during formalin fixation.	Formaldehyde	253-261	transthyretin	Homo sapiens	33-36
29034432-3	2017	Herein, we report that an uncharacterized open reading frame YKL071W from S. cerevisiae encodes a novel "classical" short-chain dehydrogenase/reductase (SDR) protein with NADH-dependent enzymatic activities for reduction of furfural (FF), glycolaldehyde (GA), formaldehyde (FA), and benzaldehyde (BZA).	Formaldehyde	260-272	short-chain dehydrogenase/reductase	Saccharomyces cerevisiae S288C	116-151
29034432-3	2017	Herein, we report that an uncharacterized open reading frame YKL071W from S. cerevisiae encodes a novel "classical" short-chain dehydrogenase/reductase (SDR) protein with NADH-dependent enzymatic activities for reduction of furfural (FF), glycolaldehyde (GA), formaldehyde (FA), and benzaldehyde (BZA).	Formaldehyde	260-272	short-chain dehydrogenase/reductase	Saccharomyces cerevisiae S288C	153-156
28922567-7	2017	METHODS: PD-L1 expression was determined by a commercially available antibody (clone 28-8) in 74 formalin-fixed, paraffin-embedded cell blocks from body effusions obtained at diagnosis from patients with MM.	Formaldehyde	97-105	CD274 molecule	Homo sapiens	9-14
28866046-7	2017	SREBP-1c, ACC, FASN, and MTP, CES3 and DGAT1 proteins increased significantly after 24h of formaldehyde treatment.	Formaldehyde	91-103	sterol regulatory element binding transcription factor 1	Homo sapiens	0-8
28844117-4	2017	Formalin-fixed paraffin-embedded tissue blocks were immunostained for vascular endothelial marker CD31 and PSMA with proper controls.	Formaldehyde	0-8	folate hydrolase 1	Homo sapiens	107-111
28866046-7	2017	SREBP-1c, ACC, FASN, and MTP, CES3 and DGAT1 proteins increased significantly after 24h of formaldehyde treatment.	Formaldehyde	91-103	fatty acid synthase	Homo sapiens	15-19
28866046-7	2017	SREBP-1c, ACC, FASN, and MTP, CES3 and DGAT1 proteins increased significantly after 24h of formaldehyde treatment.	Formaldehyde	91-103	diacylglycerol O-acyltransferase 1	Homo sapiens	39-44
28866046-9	2017	AMPKalpha increased significantly in all tested groups and p-AMPK increased significantly after 0.1mM formaldehyde treatment for 48h.	Formaldehyde	102-114	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	0-4
28866046-7	2017	SREBP-1c, ACC, FASN, and MTP, CES3 and DGAT1 proteins increased significantly after 24h of formaldehyde treatment.	Formaldehyde	91-103	metallothionein 1B	Homo sapiens	25-28
28866046-7	2017	SREBP-1c, ACC, FASN, and MTP, CES3 and DGAT1 proteins increased significantly after 24h of formaldehyde treatment.	Formaldehyde	91-103	carboxylesterase 3	Homo sapiens	30-34
29100713-3	2017	Herein, we describe a BRAF high resolution melting (HRM) assay that can differentiate low level of V600E and V600K mutations using formalin fixed, paraffin embedded (FFPE) reference standards for assay validation.	Formaldehyde	131-139	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	22-26
29032825-5	2017	We used PCR and capillary sequencing to assess the presence of specific TTC28-L1 transductions in formalin-fixed paraffin-embedded (FFPE) blocks from six different anatomical sites (five tumors and one normal control) for four ENOC and three CCOC cases, and compared the results to the presence of single nucleotide variations (SNVs)/frame shift (fs) mutations detected using multiplex PCR and next generation sequencing.	Formaldehyde	98-106	tetratricopeptide repeat domain 28	Homo sapiens	72-77
29279584-9	2017	The expression of NANOG in 100 formalin-fixed paraffin-embedded urothelial carcinoma tissues was determined by immunohistochemistry.	Formaldehyde	31-39	Nanog homeobox	Homo sapiens	18-23
28929431-0	2017	Comment on: "Comparison of Five Different Assays for the Detection of BRAF Mutations in Formalin-Fixed Paraffin Embedded Tissues of Patients with Metastatic Melanoma".	Formaldehyde	88-96	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	70-74
28929468-0	2017	Authors" Reply to Uguen: "Comparison of Five Different Assays for the Detection of BRAF Mutations in Formalin-Fixed Paraffin Embedded Tissues of Patients with Metastatic Melanoma".	Formaldehyde	101-109	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	83-87
28947236-7	2017	Moreover, local peripheral injection of m-CPBG (5-HT3 receptor agonist, 300 nmol) enhanced 0.5% formalin-induced acute and long-lasting nociception in air- and toluene-exposed rats.	Formaldehyde	96-104	5-hydroxytryptamine receptor 3A	Rattus norvegicus	48-62
28618047-0	2017	Focal beta-catenin mutation identified on formalin-fixed and paraffin-embedded inflammatory hepatocellular adenomas.	Formaldehyde	42-50	catenin beta 1	Homo sapiens	6-18
28618047-5	2017	An additional molecular analysis was performed on formalin-fixed paraffin-embedded (FFPE) material that showed focal glutamine synthetase (GS) staining, the surrogate marker of beta-catenin activation.	Formaldehyde	50-58	glutamate-ammonia ligase	Homo sapiens	117-137
29138507-3	2017	We present an mIHC platform combining fluorescent and chromogenic staining with automated whole-slide imaging and integrated whole-slide image analysis, enabling simultaneous detection of six protein markers and nuclei, and automatic quantification and classification of hundreds of thousands of cells in situ in formalin-fixed paraffin-embedded tissues.	Formaldehyde	313-321	myosin IA	Mus musculus	14-18
29166112-5	2017	We demonstrate this ansatz for the illustrative example of the stretched LiF molecule, for a range of excited states of formaldehyde, and finally for the more challenging ethylene-tetrafluoroethylene molecule.	Formaldehyde	120-132	LIF interleukin 6 family cytokine	Homo sapiens	73-76
29138507-6	2017	We conclude that the open-source combination of 8-plex mIHC detection, whole-slide image acquisition and analysis provides a robust tool allowing quantitative, spatially resolved whole-slide tissue cytometry directly in formalin-fixed human tumour tissues for improved characterization of histology and the tumour microenvironment.	Formaldehyde	220-228	myosin IA	Mus musculus	55-59
29132392-5	2017	BRAF V600E mutation results on both preoperative FNAC and postoperative formalin-fixed, paraffin-embedded (FFPE) samples were compared.	Formaldehyde	72-80	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	0-4
27919017-7	2017	Results KYNA-A1 abolished NTG-induced hyperalgesia in both pain models; NTG alone or associated to formalin injection induced an increased mRNA expression of CGRP, nNOS and cytokines in the trigeminal ganglia and central areas, which was reduced by KYNA-A1.	Formaldehyde	99-107	calcitonin-related polypeptide alpha	Rattus norvegicus	158-162
29479053-0	2017	A Computational Workflow Translates a 58-Gene Signature to a Formalin-Fixed, Paraffin-Embedded Sample-Based Companion Diagnostic for Personalized Treatment of the BRAF-Mutation-Like Subtype of Colorectal Cancers.	Formaldehyde	61-69	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	163-167
29479053-5	2017	The aim of this study is to translate this 58-gene signature from a research setting to a robust companion diagnostic that can use formalin-fixed, paraffin-embedded (FFPE) samples to select patients with the BRAF-mutation-like subtype.	Formaldehyde	131-139	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	208-212
29099815-6	2017	The expression of Hsp27 and P38MAPK were detected by immunohistochemistry in formalin-fixed paraffin embedded primary tissue specimens.	Formaldehyde	77-85	heat shock protein family B (small) member 1	Homo sapiens	18-23
27919017-7	2017	Results KYNA-A1 abolished NTG-induced hyperalgesia in both pain models; NTG alone or associated to formalin injection induced an increased mRNA expression of CGRP, nNOS and cytokines in the trigeminal ganglia and central areas, which was reduced by KYNA-A1.	Formaldehyde	99-107	nitric oxide synthase 1	Rattus norvegicus	164-168
28948627-2	2017	METHODS: C-KIT exon 11 ITDs were detected by PCR in DNA extracted from formalin-fixed, paraffin-embedded canine MCTs sourced from three veterinary diagnostic laboratories in Adelaide and Melbourne.	Formaldehyde	71-79	KIT proto-oncogene, receptor tyrosine kinase	Canis lupus familiaris	9-14
28985579-6	2017	SIRT-3 expression was investigated by immunohistochemistry (IHC) in formalin-fixed and paraffin-embedded (FFPE) samples.	Formaldehyde	68-76	sirtuin 3	Homo sapiens	0-6
28731982-5	2017	Furthermore, using the formalin behavioral nociceptive test, we demonstrated that only ipsilateral OTR activation inhibits pain behavior.	Formaldehyde	23-31	oxytocin receptor	Homo sapiens	99-102
28952648-3	2017	Hydroxyapatite (HAp), which consists of phosphate and calcium ions, worked continuously for cross-aldol reactions and Lobry de Bruyn-van Ekenstein transformations to yield ribose from formaldehyde and glycolaldehyde.	Formaldehyde	184-196	BAG cochaperone 1	Homo sapiens	16-19
29093617-3	2017	KRAS mutational status was determined by pyrosequencing analysis of DNA obtained from formalin-fixed paraffin-embedded (FFPE) tumor tissues.	Formaldehyde	86-94	KRAS proto-oncogene, GTPase	Homo sapiens	0-4
29042640-2	2017	Our goal was to validate multiplex immunofluorescence (mIF) panels to apply to formalin-fixed and paraffin-embedded tissues using a set of immune marker antibodies, with the Opal  7 color Kit (PerkinElmer) in the same tissue section.	Formaldehyde	79-87	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	55-58
29025424-2	2017	METHODS: We developed a novel 4-color mIHC assay based on tyramide signal amplification that allowed us to reliably interrogate immunologic checkpoints, including programmed death-ligand 1 (PD-L1), cytotoxic T cells (CD8+T) and regulatory T cells (Foxp3), in formalin-fixed, paraffin-embedded tissues of various human gastric diseases.	Formaldehyde	259-267	baculoviral IAP repeat-containing 3	Mus musculus	38-42
29262544-3	2017	We evaluated the Idylla  EGFR Mutation Assay (Biocartis) for the detection of EGFR mutations in archived formalin-fixed paraffin-embedded (FFPE) tumor samples from a series of 55 patients with lung adenocarcinoma and compared these results with those obtained by a pyrosequencing ISO-15189 accredited laboratory method.	Formaldehyde	105-113	epidermal growth factor receptor	Homo sapiens	78-82
28982849-4	2017	MATERIALS AND METHODS: Sphingosine kinase 1 expression was evaluated using immunohistochemical staining in 110 formalin-fixed, paraffin-embedded papillary thyroid carcinoma tissue samples.	Formaldehyde	111-119	sphingosine kinase 1	Homo sapiens	23-43
28583379-4	2017	METHODS: The presence of the FGFR4-388Arg variant was determined in 114 formalin-fixed, paraffin-embedded lung SCC tissue samples by DNA genotyping and was correlated with clinicopathologic data.	Formaldehyde	72-80	fibroblast growth factor receptor 4	Homo sapiens	29-34
28649695-8	2017	A few aromatase neurons express Fos after cheek injection of capsaicin, formalin, or chloroquine.	Formaldehyde	72-80	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	6-15
28649695-8	2017	A few aromatase neurons express Fos after cheek injection of capsaicin, formalin, or chloroquine.	Formaldehyde	72-80	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	32-35
29285256-3	2017	Methods: Immunohistochemical analyses were carried out to quantify RIP140 and LCoR expression in formalin-fixed paraffin-embedded tissue sections cervical cancer samples.	Formaldehyde	97-105	ligand dependent nuclear receptor corepressor	Homo sapiens	78-82
29294541-0	2017	[Prediction of occupational allergic contact dermatitis induced by formaldehyde by IL17/IL22 secretion cell rest combined with patch test].	Formaldehyde	67-79	interleukin 17A	Homo sapiens	83-87
29294541-0	2017	[Prediction of occupational allergic contact dermatitis induced by formaldehyde by IL17/IL22 secretion cell rest combined with patch test].	Formaldehyde	67-79	interleukin 22	Homo sapiens	88-92
29294541-1	2017	Objective: To investigate the possible role of IL17-and IL22-secreting cells combined with patch test for the prediction of formaldehyde-induced occupational allergic contact dermatitis(OACD).	Formaldehyde	124-136	interleukin 17A	Homo sapiens	47-51
29294541-1	2017	Objective: To investigate the possible role of IL17-and IL22-secreting cells combined with patch test for the prediction of formaldehyde-induced occupational allergic contact dermatitis(OACD).	Formaldehyde	124-136	interleukin 22	Homo sapiens	56-60
29294541-6	2017	The proportions of circulating CD3+CD8-IL17+ and CD3+CD8-IL22+ cells from patch-test(+) formaldehyde-exposed workers were significantly higher than that of patch-test(-)group, formaldehyde-exposed workers without skin lesions and non-exposed controls(P&lt;0.05).	Formaldehyde	88-100	CD8a molecule	Homo sapiens	35-38
29294541-6	2017	The proportions of circulating CD3+CD8-IL17+ and CD3+CD8-IL22+ cells from patch-test(+) formaldehyde-exposed workers were significantly higher than that of patch-test(-)group, formaldehyde-exposed workers without skin lesions and non-exposed controls(P&lt;0.05).	Formaldehyde	88-100	interleukin 17A	Homo sapiens	39-43
29294541-6	2017	The proportions of circulating CD3+CD8-IL17+ and CD3+CD8-IL22+ cells from patch-test(+) formaldehyde-exposed workers were significantly higher than that of patch-test(-)group, formaldehyde-exposed workers without skin lesions and non-exposed controls(P&lt;0.05).	Formaldehyde	88-100	CD8a molecule	Homo sapiens	53-56
29294541-6	2017	The proportions of circulating CD3+CD8-IL17+ and CD3+CD8-IL22+ cells from patch-test(+) formaldehyde-exposed workers were significantly higher than that of patch-test(-)group, formaldehyde-exposed workers without skin lesions and non-exposed controls(P&lt;0.05).	Formaldehyde	88-100	interleukin 22	Homo sapiens	57-61
29294541-10	2017	The percentages of CD3+CD8+IL17+and CD3+CD8+IL22+ cells inperipheral blood from patch-test(+)formaldehyde-exposed workers were enhanced significantly, compared to patch-test(-)group, formaldehyde-exposed workers without skin lesions and non-exposed controls(P&lt;0.05).	Formaldehyde	93-105	CD8a molecule	Homo sapiens	23-26
29294541-10	2017	The percentages of CD3+CD8+IL17+and CD3+CD8+IL22+ cells inperipheral blood from patch-test(+)formaldehyde-exposed workers were enhanced significantly, compared to patch-test(-)group, formaldehyde-exposed workers without skin lesions and non-exposed controls(P&lt;0.05).	Formaldehyde	93-105	CD8a molecule	Homo sapiens	40-43
29294541-10	2017	The percentages of CD3+CD8+IL17+and CD3+CD8+IL22+ cells inperipheral blood from patch-test(+)formaldehyde-exposed workers were enhanced significantly, compared to patch-test(-)group, formaldehyde-exposed workers without skin lesions and non-exposed controls(P&lt;0.05).	Formaldehyde	93-105	interleukin 22	Homo sapiens	44-48
29294541-13	2017	Conclusion: The proportions of circulating IL17+ and IL22+T cells(both CD8-and CD8+)are enhanced in formaldehyde-exposed workers at proposed OEL, possibly involved in the development of formaldehyde-induced OACD.The detection of IL17-and IL22-secreting cells combined with formaldehyde patch test help to screen the workers with allergy property and prevent OACD.	Formaldehyde	100-112	interleukin 17A	Homo sapiens	43-47
29294541-13	2017	Conclusion: The proportions of circulating IL17+ and IL22+T cells(both CD8-and CD8+)are enhanced in formaldehyde-exposed workers at proposed OEL, possibly involved in the development of formaldehyde-induced OACD.The detection of IL17-and IL22-secreting cells combined with formaldehyde patch test help to screen the workers with allergy property and prevent OACD.	Formaldehyde	100-112	interleukin 22	Homo sapiens	53-57
29294541-13	2017	Conclusion: The proportions of circulating IL17+ and IL22+T cells(both CD8-and CD8+)are enhanced in formaldehyde-exposed workers at proposed OEL, possibly involved in the development of formaldehyde-induced OACD.The detection of IL17-and IL22-secreting cells combined with formaldehyde patch test help to screen the workers with allergy property and prevent OACD.	Formaldehyde	100-112	CD8a molecule	Homo sapiens	71-74
29294541-13	2017	Conclusion: The proportions of circulating IL17+ and IL22+T cells(both CD8-and CD8+)are enhanced in formaldehyde-exposed workers at proposed OEL, possibly involved in the development of formaldehyde-induced OACD.The detection of IL17-and IL22-secreting cells combined with formaldehyde patch test help to screen the workers with allergy property and prevent OACD.	Formaldehyde	100-112	CD8a molecule	Homo sapiens	79-82
29294541-13	2017	Conclusion: The proportions of circulating IL17+ and IL22+T cells(both CD8-and CD8+)are enhanced in formaldehyde-exposed workers at proposed OEL, possibly involved in the development of formaldehyde-induced OACD.The detection of IL17-and IL22-secreting cells combined with formaldehyde patch test help to screen the workers with allergy property and prevent OACD.	Formaldehyde	100-112	interleukin 17A	Homo sapiens	229-233
29294541-13	2017	Conclusion: The proportions of circulating IL17+ and IL22+T cells(both CD8-and CD8+)are enhanced in formaldehyde-exposed workers at proposed OEL, possibly involved in the development of formaldehyde-induced OACD.The detection of IL17-and IL22-secreting cells combined with formaldehyde patch test help to screen the workers with allergy property and prevent OACD.	Formaldehyde	100-112	interleukin 22	Homo sapiens	238-242
29294541-13	2017	Conclusion: The proportions of circulating IL17+ and IL22+T cells(both CD8-and CD8+)are enhanced in formaldehyde-exposed workers at proposed OEL, possibly involved in the development of formaldehyde-induced OACD.The detection of IL17-and IL22-secreting cells combined with formaldehyde patch test help to screen the workers with allergy property and prevent OACD.	Formaldehyde	186-198	interleukin 17A	Homo sapiens	43-47
29294541-13	2017	Conclusion: The proportions of circulating IL17+ and IL22+T cells(both CD8-and CD8+)are enhanced in formaldehyde-exposed workers at proposed OEL, possibly involved in the development of formaldehyde-induced OACD.The detection of IL17-and IL22-secreting cells combined with formaldehyde patch test help to screen the workers with allergy property and prevent OACD.	Formaldehyde	186-198	interleukin 22	Homo sapiens	53-57
29294541-13	2017	Conclusion: The proportions of circulating IL17+ and IL22+T cells(both CD8-and CD8+)are enhanced in formaldehyde-exposed workers at proposed OEL, possibly involved in the development of formaldehyde-induced OACD.The detection of IL17-and IL22-secreting cells combined with formaldehyde patch test help to screen the workers with allergy property and prevent OACD.	Formaldehyde	186-198	CD8a molecule	Homo sapiens	71-74
29294541-13	2017	Conclusion: The proportions of circulating IL17+ and IL22+T cells(both CD8-and CD8+)are enhanced in formaldehyde-exposed workers at proposed OEL, possibly involved in the development of formaldehyde-induced OACD.The detection of IL17-and IL22-secreting cells combined with formaldehyde patch test help to screen the workers with allergy property and prevent OACD.	Formaldehyde	186-198	CD8a molecule	Homo sapiens	79-82
29294541-13	2017	Conclusion: The proportions of circulating IL17+ and IL22+T cells(both CD8-and CD8+)are enhanced in formaldehyde-exposed workers at proposed OEL, possibly involved in the development of formaldehyde-induced OACD.The detection of IL17-and IL22-secreting cells combined with formaldehyde patch test help to screen the workers with allergy property and prevent OACD.	Formaldehyde	186-198	interleukin 17A	Homo sapiens	229-233
29294541-13	2017	Conclusion: The proportions of circulating IL17+ and IL22+T cells(both CD8-and CD8+)are enhanced in formaldehyde-exposed workers at proposed OEL, possibly involved in the development of formaldehyde-induced OACD.The detection of IL17-and IL22-secreting cells combined with formaldehyde patch test help to screen the workers with allergy property and prevent OACD.	Formaldehyde	186-198	interleukin 22	Homo sapiens	238-242
29294541-13	2017	Conclusion: The proportions of circulating IL17+ and IL22+T cells(both CD8-and CD8+)are enhanced in formaldehyde-exposed workers at proposed OEL, possibly involved in the development of formaldehyde-induced OACD.The detection of IL17-and IL22-secreting cells combined with formaldehyde patch test help to screen the workers with allergy property and prevent OACD.	Formaldehyde	186-198	interleukin 17A	Homo sapiens	43-47
29294541-13	2017	Conclusion: The proportions of circulating IL17+ and IL22+T cells(both CD8-and CD8+)are enhanced in formaldehyde-exposed workers at proposed OEL, possibly involved in the development of formaldehyde-induced OACD.The detection of IL17-and IL22-secreting cells combined with formaldehyde patch test help to screen the workers with allergy property and prevent OACD.	Formaldehyde	186-198	interleukin 22	Homo sapiens	53-57
29294541-13	2017	Conclusion: The proportions of circulating IL17+ and IL22+T cells(both CD8-and CD8+)are enhanced in formaldehyde-exposed workers at proposed OEL, possibly involved in the development of formaldehyde-induced OACD.The detection of IL17-and IL22-secreting cells combined with formaldehyde patch test help to screen the workers with allergy property and prevent OACD.	Formaldehyde	186-198	CD8a molecule	Homo sapiens	71-74
29294541-13	2017	Conclusion: The proportions of circulating IL17+ and IL22+T cells(both CD8-and CD8+)are enhanced in formaldehyde-exposed workers at proposed OEL, possibly involved in the development of formaldehyde-induced OACD.The detection of IL17-and IL22-secreting cells combined with formaldehyde patch test help to screen the workers with allergy property and prevent OACD.	Formaldehyde	186-198	CD8a molecule	Homo sapiens	79-82
29294541-13	2017	Conclusion: The proportions of circulating IL17+ and IL22+T cells(both CD8-and CD8+)are enhanced in formaldehyde-exposed workers at proposed OEL, possibly involved in the development of formaldehyde-induced OACD.The detection of IL17-and IL22-secreting cells combined with formaldehyde patch test help to screen the workers with allergy property and prevent OACD.	Formaldehyde	186-198	interleukin 17A	Homo sapiens	229-233
29294541-13	2017	Conclusion: The proportions of circulating IL17+ and IL22+T cells(both CD8-and CD8+)are enhanced in formaldehyde-exposed workers at proposed OEL, possibly involved in the development of formaldehyde-induced OACD.The detection of IL17-and IL22-secreting cells combined with formaldehyde patch test help to screen the workers with allergy property and prevent OACD.	Formaldehyde	186-198	interleukin 22	Homo sapiens	238-242
27556822-4	2017	SDHB IHC was performed on formalin-fixed, paraffin-embedded tissue sections with a mouse monoclonal antibody (Abcam 21A11AE7) in parallel with histochemical SDH stains on a fresh-frozen tissue.	Formaldehyde	26-34	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	0-4
27556822-4	2017	SDHB IHC was performed on formalin-fixed, paraffin-embedded tissue sections with a mouse monoclonal antibody (Abcam 21A11AE7) in parallel with histochemical SDH stains on a fresh-frozen tissue.	Formaldehyde	26-34	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	0-3
28540429-11	2017	Adipophilin immunohistochemistry was highly dependent on the preanalytical time interval (PATI) from removal of the tissue to formalin fixation.	Formaldehyde	126-134	perilipin 2	Homo sapiens	0-11
28722111-3	2017	Here, we evaluated MAOA in 427 cases of Hodgkin and non-Hodgkin lymphoma and in a spectrum of reactive lymphoid tissues by immunohistochemistry on formalin-fixed, paraffin-embedded specimens.	Formaldehyde	147-155	monoamine oxidase A	Homo sapiens	19-23
28899740-6	2017	Direct sequencing for the presence of H3F3A and H3F3B variants in coding region between codons 1 and 42, including the hotspot codons (28, 35, and 37), was performed on DNA extracted from formalin-fixed, paraffin-embedded tissue using conventional polymerase chain reaction and fast coamplification at lower denaturation temperature-polymerase chain reaction.	Formaldehyde	188-196	H3.3 histone A	Homo sapiens	38-43
28899740-6	2017	Direct sequencing for the presence of H3F3A and H3F3B variants in coding region between codons 1 and 42, including the hotspot codons (28, 35, and 37), was performed on DNA extracted from formalin-fixed, paraffin-embedded tissue using conventional polymerase chain reaction and fast coamplification at lower denaturation temperature-polymerase chain reaction.	Formaldehyde	188-196	H3.3 histone B	Homo sapiens	48-53
28848996-3	2017	In the present study, ROCK1 expression was examined in 356 formalin-fixed, paraffin-embedded papillary thyroid carcinoma tissues using immunohistochemistry, and its clinical implications and prognostic significance were analyzed.	Formaldehyde	59-67	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	22-27
28755528-3	2017	In this study, recombinant KLK4 protein was generated and affinity-purified KLK4-directed polyclonal antibody pAb587 established to allow localization of KLK4 protein expression in tumor cell lines and archived formalin-fixed, paraffin-embedded TNBC tumor tissue specimens.	Formaldehyde	211-219	kallikrein related peptidase 4	Homo sapiens	27-31
28823609-6	2017	Accordingly, formalin-induced nociceptive behavior was increased in wild-type mice after administration of the KCa3.1 inhibitor TRAM-34.	Formaldehyde	13-21	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4	Mus musculus	111-117
28623711-3	2017	PSAP was administered intragastrically (ig) 30min prior to formalin or glutamate test and compared with a standard drug, meloxicam (10mg/kg, ig).	Formaldehyde	59-67	prosaposin	Mus musculus	0-4
28623711-4	2017	RESULTS: The treatment with PSAP (10-50mg/kg) caused inhibition in the neurogenic phase and reduced the paw oedema caused by intraplantar (ipl) injection of formalin.	Formaldehyde	157-165	prosaposin	Mus musculus	28-32
28623711-5	2017	PSAP (1-50mg/kg) decreased the nociceptive response in the inflammatory phase of the formalin test and in licking behaviour triggered by glutamate at doses of 0.1-50mg/kg.	Formaldehyde	85-93	prosaposin	Mus musculus	0-4
28623711-9	2017	CONCLUSION: These results showed the antinociceptive action of PSAP in formalin and glutamate tests and the involvement of the dopaminergic and adrenergic systems in its antinociceptive activity.	Formaldehyde	71-79	prosaposin	Mus musculus	63-67
28589341-8	2017	However, droplet digital polymerase chain reaction is a promising and reliable assay that can be used as a diagnostic tool to genotype formalin-fixed paraffin-embedded cancer samples for EGFR or another clinically relevant somatic mutation.	Formaldehyde	135-143	epidermal growth factor receptor	Homo sapiens	187-191
28627450-2	2017	The most sensitive assays for KRAS mutation detection in formalin-fixed paraffin embedded (FFPE) tissues are based on real-time PCR.	Formaldehyde	57-65	KRAS proto-oncogene, GTPase	Homo sapiens	30-34
28992761-4	2017	One candidate for such test is fully integrated, real-time polymerase chain reaction-based Idylla  system for quick and simple detection of KRAS mutations in formaldehyde fixed-paraffin embedded tumor samples.	Formaldehyde	158-170	KRAS proto-oncogene, GTPase	Homo sapiens	140-144
29093818-5	2017	Using the 19G core-biopsy needle and processing the microbiopsy samples in formalin provided more material for predictive biomarker testing, including PD-L1 immunohistochemistry, when traditional processing was inadequate.	Formaldehyde	75-83	CD274 molecule	Homo sapiens	151-156
28832142-1	2017	Reaction species were studied by multiplexed photoionization mass spectrometry at 550 and 650 K. The oxygen addition pathway is favored in this reaction, forming four triplet diradicals that undergo intersystem crossing into singlet epoxide species that lead to the formation of products at m/z 30 (formaldehyde), 42 (propene), 54 (1-butyne, 1,3-butadiene, and 2-butyne), and 70 (2-butenal, methyl vinyl ketone, and 3-butenal).	Formaldehyde	299-311	small nucleolar RNA, C/D box 7	Homo sapiens	293-297
29202546-3	2017	We evaluated the formalin-fixed paraffin-embedded lymph node biopsy specimens from 55 patients by using monoclonal antibody against MCM-6 and compared these findings with clinical data and treatment outcome.	Formaldehyde	17-25	minichromosome maintenance complex component 6	Homo sapiens	132-137
28931832-0	2017	Mediating Role of TRPV1 Ion Channels in the Co-exposure to PM2.5 and Formaldehyde of Balb/c Mice Asthma Model.	Formaldehyde	69-81	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	18-23
28720682-0	2017	Reducing Artifactual EGFR T790M Mutations in DNA from Formalin-Fixed Paraffin-Embedded Tissue by Use of Thymine-DNA Glycosylase.	Formaldehyde	54-62	epidermal growth factor receptor	Homo sapiens	21-25
28720682-0	2017	Reducing Artifactual EGFR T790M Mutations in DNA from Formalin-Fixed Paraffin-Embedded Tissue by Use of Thymine-DNA Glycosylase.	Formaldehyde	54-62	thymine DNA glycosylase	Homo sapiens	104-127
28720682-1	2017	BACKGROUND: False-positive EGFR T790M mutations have been reported in formalin-fixed lung tumors, but the cause of the false positives has not been identified.	Formaldehyde	70-78	epidermal growth factor receptor	Homo sapiens	27-31
28720682-8	2017	RESULTS: Artifactual EGFR T790M mutations were detected in all of the archival formalin-fixed normal lung and lung squamous cell carcinomas at mutant allele frequencies of 1% or lower.	Formaldehyde	79-87	epidermal growth factor receptor	Homo sapiens	21-25
28720682-10	2017	Pretreatment of the formalin-fixed DNA with either UDG or TDG reduced the false EGFR T790M mutations, but a greater reduction was seen with the TDG treatment.	Formaldehyde	20-28	uracil DNA glycosylase	Homo sapiens	51-54
28720682-10	2017	Pretreatment of the formalin-fixed DNA with either UDG or TDG reduced the false EGFR T790M mutations, but a greater reduction was seen with the TDG treatment.	Formaldehyde	20-28	thymine DNA glycosylase	Homo sapiens	58-61
28720682-10	2017	Pretreatment of the formalin-fixed DNA with either UDG or TDG reduced the false EGFR T790M mutations, but a greater reduction was seen with the TDG treatment.	Formaldehyde	20-28	epidermal growth factor receptor	Homo sapiens	80-84
28720682-10	2017	Pretreatment of the formalin-fixed DNA with either UDG or TDG reduced the false EGFR T790M mutations, but a greater reduction was seen with the TDG treatment.	Formaldehyde	20-28	thymine DNA glycosylase	Homo sapiens	144-147
28720682-11	2017	CONCLUSIONS: Both U:G and T:G lesions in formalin-fixed tissue are sources of false-positive EGFR T790M mutations.	Formaldehyde	41-49	epidermal growth factor receptor	Homo sapiens	93-97
28720682-12	2017	This is the first report of the use of TDG to reduce sequence artifacts in formalin-fixed DNA and is applicable to the accurate detection of mutations arising at methylated cytosines.	Formaldehyde	75-83	thymine DNA glycosylase	Homo sapiens	39-42
28833700-9	2017	In contrast, the acute nociceptive behavior immediately after the formalin injection was reduced only at 20-25 min post-injection in the CGRP KO mice.	Formaldehyde	66-74	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	137-141
28477388-6	2017	Direct sequencing for H3F3A mutations in coding regions between codons 1 and 42, including the hotspot codons (28, 35, and 37), was performed on DNA extracted from formalin-fixed paraffin-embedded tissue.	Formaldehyde	164-172	H3.3 histone A	Homo sapiens	22-27
28927067-3	2017	miR-146a was evaluated in formalin-fixed, paraffin-embedded samples.	Formaldehyde	26-34	microRNA 146a	Homo sapiens	0-8
28409272-6	2017	METHODS: Immunohistochemical analyses were carried out to detect TAAR1 expression in formalin fixed paraffin embedded breast cancer samples.	Formaldehyde	85-93	trace amine associated receptor 1	Homo sapiens	65-70
28247010-6	2017	Real-time PCR analysis conducted using formalin-fixed paraffin-embedded tissues with atherosclerotic lesions demonstrated an increase in the levels of many inflammatory chemokines, including Cxcl16, while antibody arrays performed using frozen atherosclerotic tissue samples showed elevated TIMP-1 expression.	Formaldehyde	39-47	chemokine (C-X-C motif) ligand 16	Mus musculus	191-197
28247010-6	2017	Real-time PCR analysis conducted using formalin-fixed paraffin-embedded tissues with atherosclerotic lesions demonstrated an increase in the levels of many inflammatory chemokines, including Cxcl16, while antibody arrays performed using frozen atherosclerotic tissue samples showed elevated TIMP-1 expression.	Formaldehyde	39-47	tissue inhibitor of metalloproteinase 1	Mus musculus	291-297
28697061-6	2017	CONCLUSIONS: Low-level formaldehyde exposure may increase circulating IL17-/IL22-producing T cells (CD8 and CD8), possibly involved in the development of human OACD.	Formaldehyde	23-35	interleukin 17A	Homo sapiens	70-74
28697061-6	2017	CONCLUSIONS: Low-level formaldehyde exposure may increase circulating IL17-/IL22-producing T cells (CD8 and CD8), possibly involved in the development of human OACD.	Formaldehyde	23-35	interleukin 22	Homo sapiens	76-80
28697061-6	2017	CONCLUSIONS: Low-level formaldehyde exposure may increase circulating IL17-/IL22-producing T cells (CD8 and CD8), possibly involved in the development of human OACD.	Formaldehyde	23-35	CD8a molecule	Homo sapiens	100-103
28697061-6	2017	CONCLUSIONS: Low-level formaldehyde exposure may increase circulating IL17-/IL22-producing T cells (CD8 and CD8), possibly involved in the development of human OACD.	Formaldehyde	23-35	CD8a molecule	Homo sapiens	108-111
28673711-0	2017	Activation of P2X3 receptors in the cerebrospinal fluid-contacting nucleus neurons reduces formalin-induced pain behavior via PAG in a rat model.	Formaldehyde	91-99	purinergic receptor P2X 3	Rattus norvegicus	14-18
28673711-3	2017	Our present experiment investigated the functionality of P2X3 receptors in CSF-contacting nucleus in the formalin-evoked inflammatory pain.	Formaldehyde	105-113	purinergic receptor P2X 3	Rattus norvegicus	57-61
28673711-4	2017	Immunofluorescence and western blot revealed the expression of P2X3 receptors in the CSF-contacting nucleus and their upregulated expression subsequent to administration of formalin in rat model.	Formaldehyde	173-181	purinergic receptor P2X 3	Rattus norvegicus	63-67
28673722-11	2017	In control animals BoNT/A reduced the formalin-evoked c-Fos expression in lumbar dorsal horn, while in knockout mice the c-Fos expression was not reduced.	Formaldehyde	38-46	FBJ osteosarcoma oncogene	Mus musculus	54-59
28810295-1	2017	Objective: To evaluate the sensitivity, specificity and clinical value of anti-BRAF V600E antibody (clone VE1) in detection of the BRAF V600E mutant in formalin-fixed and paraffin-embedded (FFPE) melanoma specimens by immunohistochemical (IHC) methods.	Formaldehyde	152-160	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	79-83
27028240-3	2017	To address this, we have developed a 2-step diagnostic test to identify NTRK1, NTRK2, NTRK3, ROS1, and ALK rearrangements in formalin-fixed paraffin-embedded clinical specimens.	Formaldehyde	125-133	ALK receptor tyrosine kinase	Homo sapiens	103-106
28750448-6	2017	ErbB mRNA expression levels were determined after extraction from formalin-fixed, paraffin-embedded tissue.	Formaldehyde	66-74	epidermal growth factor receptor	Homo sapiens	0-4
28978000-4	2017	PD-L1 was measured on formalin-fixed, paraffin-embedded tissue sections of RC specimens in all patients (n=61) and in 27 matched metastatic biopsy samples by immunohistochemistry.	Formaldehyde	22-30	CD274 molecule	Homo sapiens	0-5
27028240-3	2017	To address this, we have developed a 2-step diagnostic test to identify NTRK1, NTRK2, NTRK3, ROS1, and ALK rearrangements in formalin-fixed paraffin-embedded clinical specimens.	Formaldehyde	125-133	neurotrophic receptor tyrosine kinase 1	Homo sapiens	72-77
29256235-0	2017	[Volume of 4% neutral buffered formaldehyde affects the results of HER2 gene detected by fluorescence in situ hybridization in primary invasive breast cancer].	Formaldehyde	31-43	erb-b2 receptor tyrosine kinase 2	Homo sapiens	67-71
28067406-5	2017	We further observed the Ninj1 homomeric complexes composed of two to six monomeric Ninj1 molecules by a formaldehyde cross-linking assay.	Formaldehyde	104-116	ninjurin 1	Homo sapiens	24-29
28067406-5	2017	We further observed the Ninj1 homomeric complexes composed of two to six monomeric Ninj1 molecules by a formaldehyde cross-linking assay.	Formaldehyde	104-116	ninjurin 1	Homo sapiens	83-88
28527956-0	2017	Comparison of the induction of c-fos-eGFP and Fos protein in the rat spinal cord and hypothalamus resulting from subcutaneous capsaicin or formalin injection.	Formaldehyde	139-147	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	31-36
28527956-0	2017	Comparison of the induction of c-fos-eGFP and Fos protein in the rat spinal cord and hypothalamus resulting from subcutaneous capsaicin or formalin injection.	Formaldehyde	139-147	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	46-49
28527956-7	2017	Following capsaicin or formalin treatment, eGFP was maximally expressed at 6h in the spinal cord and 3h in the PVN and SON, whereas, Fos-LI was maximally expressed at 1.5h in all the regions we analyzed.	Formaldehyde	23-31	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	133-136
28527956-8	2017	Induction of eGFP in the OXT neurons was observed after capsaicin or formalin treatment, while Fos-LI in the OXT neurons was observed only after formalin treatment.	Formaldehyde	69-77	oxytocin/neurophysin I prepropeptide	Rattus norvegicus	25-28
28527956-8	2017	Induction of eGFP in the OXT neurons was observed after capsaicin or formalin treatment, while Fos-LI in the OXT neurons was observed only after formalin treatment.	Formaldehyde	145-153	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	95-98
28527956-8	2017	Induction of eGFP in the OXT neurons was observed after capsaicin or formalin treatment, while Fos-LI in the OXT neurons was observed only after formalin treatment.	Formaldehyde	145-153	oxytocin/neurophysin I prepropeptide	Rattus norvegicus	109-112
28629594-4	2017	Herein, we report the discovery and optimization of novel benzoxazine sulfonamide inhibitors of human, rat and mouse NaV1.7 which enabled pharmacological assessment in traditional behavioral rodent models of pain and in turn, established a connection between formalin-induced pain and histamine-induced pruritus in mice.	Formaldehyde	259-267	sodium channel, voltage-gated, type IX, alpha	Mus musculus	117-123
28237182-4	2017	METHODS: c-Met expression was analyzed from 137 formalin-fixed paraffin-embedded tumor samples using a validated immunostaining protocol.	Formaldehyde	48-56	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	9-14
28137728-2	2017	METHODS: Fusion gene detection using a next-generation sequencing-based anchored multiplex PCR technique (Archer FusionPlex Sarcoma Panel) was used to identify the novel fusion breakpoints of this CIC-DUX4 sarcoma using formalin-fixed and paraffin-embedded tumour material.	Formaldehyde	220-228	double homeobox 4	Homo sapiens	201-205
28376189-4	2017	BRCA1/2 testing of most prevalent mutations was mainly done using DNA isolate from formalin-fixed paraffin-embedded nontumor tissue.	Formaldehyde	83-91	BRCA1 DNA repair associated	Homo sapiens	0-5
28498805-2	2017	In this study, the impact of FOXM1 expression on patient outcome was investigated for the first time in formalin fixed and paraffin embedded (FFPE) samples of chemotherapy naive muscle-invasive bladder cancer (MIBC) patients.	Formaldehyde	104-112	forkhead box M1	Homo sapiens	29-34
28671225-1	2017	The mechanism of the CO + H2  H2CO reaction catalyzed by acidic systems was investigated theoretically using the ab initio MP2 and CCSD(T) methods and the aug-cc-pVDZ basis set (the effects of the surrounding solvent molecules were approximated by employing the polarized continuum solvation model).	Formaldehyde	30-34	tryptase pseudogene 1	Homo sapiens	123-126
28740441-6	2017	Extractive molecular assays are expensive and laborious methods, but they specifically recognize almost all ROS1 fusions using a limited amount of mRNA even from formalin-fixed, paraffin-embedded tumor tissues.	Formaldehyde	162-170	ROS proto-oncogene 1, receptor tyrosine kinase	Homo sapiens	108-112
28625519-5	2017	All 33 EGFR-activating mutations detected in formalin-fixed paraffin-embedded (FFPE) tissue samples by the conventional method were also detected by this multiplex assay.	Formaldehyde	45-53	epidermal growth factor receptor	Homo sapiens	7-11
28678832-3	2017	Immunohistochemical staining for MDM2 and p53 with formalin-fixed, paraffin-embedded tumor tissues was independently reviewed.	Formaldehyde	51-59	MDM2 proto-oncogene	Homo sapiens	33-37
28862608-6	2017	Using cross-linkages with formaldehyde, we showed that this cytoplasmic PCNA is cross-linked in a similar way, that is, organized in the same way as the nuclear PCNA that is present in the proliferating cells.	Formaldehyde	26-38	proliferating cell nuclear antigen	Homo sapiens	72-76
28862608-6	2017	Using cross-linkages with formaldehyde, we showed that this cytoplasmic PCNA is cross-linked in a similar way, that is, organized in the same way as the nuclear PCNA that is present in the proliferating cells.	Formaldehyde	26-38	proliferating cell nuclear antigen	Homo sapiens	161-165
28952224-6	2017	METHODS: In this retrospective study, we assessed the relation of PDGFR alpha and PDGFR beta immunohistochemical expression with MVD in formalin-fixed paraffin-embedded bone marrow sections from 120 NDMM patients.	Formaldehyde	136-144	platelet derived growth factor receptor alpha	Homo sapiens	66-77
28419866-3	2017	While initially recognized as the enzyme that is involved in formaldehyde detoxification, increasing amount of evidence has shown that GSNOR also plays a significant role in nitric oxide mediated signaling through its modulation of protein S-nitrosothiol signaling.	Formaldehyde	61-73	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	135-140
28188754-7	2017	High-throughput RNA sequencing of a formalin-fixed, paraffin-embedded clinical sample unveiled a novel NUTM2A-CIC fusion between NUTM2A exon 7 and CIC exon 12, and fluorescence in situ hybridization identified CIC and NUTM2A split signals.	Formaldehyde	36-44	NUT family member 2A	Homo sapiens	103-109
28188754-7	2017	High-throughput RNA sequencing of a formalin-fixed, paraffin-embedded clinical sample unveiled a novel NUTM2A-CIC fusion between NUTM2A exon 7 and CIC exon 12, and fluorescence in situ hybridization identified CIC and NUTM2A split signals.	Formaldehyde	36-44	NUT family member 2A	Homo sapiens	129-135
28188754-7	2017	High-throughput RNA sequencing of a formalin-fixed, paraffin-embedded clinical sample unveiled a novel NUTM2A-CIC fusion between NUTM2A exon 7 and CIC exon 12, and fluorescence in situ hybridization identified CIC and NUTM2A split signals.	Formaldehyde	36-44	NUT family member 2A	Homo sapiens	129-135
28952224-6	2017	METHODS: In this retrospective study, we assessed the relation of PDGFR alpha and PDGFR beta immunohistochemical expression with MVD in formalin-fixed paraffin-embedded bone marrow sections from 120 NDMM patients.	Formaldehyde	136-144	platelet derived growth factor receptor beta	Homo sapiens	82-92
28415912-1	2017	A novel immunohistochemistry (IHC) approach has been developed to label and localize osterix, a bone-specific transcription factor, within formalin-fixed, paraffin-embedded, tissue-engineered constructs uniquely containing synthetic polymers and human periosteal tissue.	Formaldehyde	139-147	Sp7 transcription factor	Homo sapiens	85-92
28382595-6	2017	At a dose of 8 mg/kg, NAX 810-2 significantly attenuated nociceptive behaviors following plantar administration of formalin, and this was observed for both phase I (acute) and phase II (inflammatory) components of the formalin behavioral response.	Formaldehyde	115-123	sodium channel, voltage-gated, type VII, alpha	Mus musculus	22-25
28534992-3	2017	In the present study, the expression levels of IDH-1 and HIF-1alpha in 35 formalin-fixed paraffin-embedded sections from osteosarcoma patients were investigated by immunohistochemistry.	Formaldehyde	74-82	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	47-52
28534992-3	2017	In the present study, the expression levels of IDH-1 and HIF-1alpha in 35 formalin-fixed paraffin-embedded sections from osteosarcoma patients were investigated by immunohistochemistry.	Formaldehyde	74-82	hypoxia inducible factor 1 subunit alpha	Homo sapiens	57-67
28649946-0	2017	Choline Transporter Immunohistochemistry: An Effective Substitute for Acetylcholinesterase Histochemistry to Diagnose Hirschsprung Disease With Formalin-fixed Paraffin-embedded Rectal Biopsies.	Formaldehyde	144-152	solute carrier family 5 member 7	Homo sapiens	0-19
28382595-4	2017	NAX 810-2 was evaluated in mouse (carrageenan, formalin, tail flick, plantar incision) and rat pain models (partial sciatic nerve ligation).	Formaldehyde	47-55	sodium channel, voltage-gated, type VII, alpha	Mus musculus	0-3
28382595-6	2017	At a dose of 8 mg/kg, NAX 810-2 significantly attenuated nociceptive behaviors following plantar administration of formalin, and this was observed for both phase I (acute) and phase II (inflammatory) components of the formalin behavioral response.	Formaldehyde	218-226	sodium channel, voltage-gated, type VII, alpha	Mus musculus	22-25
28575672-3	2017	Formaldehyde selectively depletes BRCA2 via proteasomal degradation, a mechanism of toxicity that affects very few additional cellular proteins.	Formaldehyde	0-12	BRCA2 DNA repair associated	Homo sapiens	34-39
30480186-7	2017	AR immunohistochemistry was done on formalin-fixed, paraffin-embedded tissue blocks.	Formaldehyde	36-44	androgen receptor	Homo sapiens	0-2
28587664-10	2017	We now describe a protocol to extract and measure tau seeding activity from small volumes (.04 mm3) of formaldehyde-fixed tissue immediately adjacent to that used for IHC.	Formaldehyde	103-115	microtubule associated protein tau	Homo sapiens	50-53
28621308-6	2017	Interestingly, behavioral alteration caused by toluene or formaldehyde exposure was most severe in the p38b mutant, suggesting that the defects in the p38 pathway underlie behavioral alteration.	Formaldehyde	58-70	p38b MAP kinase	Drosophila melanogaster	103-107
28588314-2	2017	Here, we analyzed GNAS mutations in FD which were performed by pyrosequencing DNA isolated from formalin-fixed paraffin-embedded (FFPE) tissue.	Formaldehyde	96-104	GNAS complex locus	Homo sapiens	18-22
28433055-9	2017	Results demonstrate that pyrenyl carbon nanostructures-based FDH bioelectrode design represents novelty and simplicity for enzyme-selective electrochemical quantitation of small 30 Da formaldehyde.	Formaldehyde	184-196	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	61-64
28323289-2	2017	METHODS: We used modified BIOMED-2 protocols to detect monoclonal expansions of immunoglobulin heavy chain (IgH) and T-cell receptor (TCR) genes in 957 formalin-fixed paraffin-embedded samples from 717 patients.	Formaldehyde	152-160	immunoglobulin heavy constant delta	Homo sapiens	80-106
28323289-2	2017	METHODS: We used modified BIOMED-2 protocols to detect monoclonal expansions of immunoglobulin heavy chain (IgH) and T-cell receptor (TCR) genes in 957 formalin-fixed paraffin-embedded samples from 717 patients.	Formaldehyde	152-160	immunoglobulin heavy constant delta	Homo sapiens	108-111
28441717-14	2017	In conclusion, our study demonstrated that DEX could inhibit formaldehyde-induced pain by inhibiting nNOS, PKCgamma and PAR2 expression through alpha2 adrenergic receptor and imidazoline receptor.	Formaldehyde	61-73	nitric oxide synthase 1	Rattus norvegicus	101-105
28441717-14	2017	In conclusion, our study demonstrated that DEX could inhibit formaldehyde-induced pain by inhibiting nNOS, PKCgamma and PAR2 expression through alpha2 adrenergic receptor and imidazoline receptor.	Formaldehyde	61-73	protein kinase C, gamma	Rattus norvegicus	107-115
28441717-14	2017	In conclusion, our study demonstrated that DEX could inhibit formaldehyde-induced pain by inhibiting nNOS, PKCgamma and PAR2 expression through alpha2 adrenergic receptor and imidazoline receptor.	Formaldehyde	61-73	F2R like trypsin receptor 1	Rattus norvegicus	120-124
28575672-4	2017	Heterozygous BRCA2 truncations, by lowering pre-existing BRCA2 expression, sensitize to BRCA2 haploinsufficiency induced by transient exposure to natural concentrations of formaldehyde.	Formaldehyde	172-184	BRCA2 DNA repair associated	Homo sapiens	13-18
28575672-4	2017	Heterozygous BRCA2 truncations, by lowering pre-existing BRCA2 expression, sensitize to BRCA2 haploinsufficiency induced by transient exposure to natural concentrations of formaldehyde.	Formaldehyde	172-184	BRCA2 DNA repair associated	Homo sapiens	57-62
28575672-4	2017	Heterozygous BRCA2 truncations, by lowering pre-existing BRCA2 expression, sensitize to BRCA2 haploinsufficiency induced by transient exposure to natural concentrations of formaldehyde.	Formaldehyde	172-184	BRCA2 DNA repair associated	Homo sapiens	57-62
28334446-1	2017	Capillary electrophoresis with laser-induced fluorescence (CE-LIF) detection was used to analyze endoglycosidase released and fluorophore-labeled N-glycans from formalin-fixed paraffin-embedded (FFPE) mouse tissue samples of lung, brain, heart, spleen, liver, kidney and intestine.	Formaldehyde	161-169	leukemia inhibitory factor	Mus musculus	62-65
28159592-5	2017	After the secondary stimulation with V. splendidus, the expression levels of CgClec-4 and CgIFN in the gill of oysters pre-stimulated with formaldehyde-killed V. splendidus were significantly higher (p &lt; 0.05) than that in the oysters pre-stimulated with filter-sterilized (0.22 mum pore size) sea water, while the expression level of CgIL-17 was significantly decreased (p &lt; 0.05).	Formaldehyde	139-151	interleukin 17-like protein	Crassostrea gigas	338-345
28393572-3	2017	GSNOR metabolizes S-nitrosoglutathione (GSNO), S-hydroxymethylglutathione (the spontaneous adduct of formaldehyde and glutathione), and some alcohols.	Formaldehyde	101-113	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	0-5
28570125-4	2017	A high omega-3 PUFA tissue content attenuated formalin-induced pain sensitivity, microglial activation, inducible nitric oxide synthase expression, and the phosphorylation of NR2B, a subunit of the N-methyl-d-aspartate (NMDA) receptor.	Formaldehyde	46-54	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	175-179
28440399-3	2017	Herein, we first examined AAT expression in a panel of formalin-fixed paraffin-embedded tumor tissues from 88 lung adenocarcinoma patients undergoing curative resection, using immunohistochemical methods.	Formaldehyde	55-63	serpin family A member 1	Homo sapiens	26-29
28153953-0	2017	Evaluation of a fast and fully automated platform to diagnose EGFR and KRAS mutations in formalin-fixed and paraffin-embedded non-small cell lung cancer samples in less than one day.	Formaldehyde	89-97	epidermal growth factor receptor	Homo sapiens	62-66
28153953-0	2017	Evaluation of a fast and fully automated platform to diagnose EGFR and KRAS mutations in formalin-fixed and paraffin-embedded non-small cell lung cancer samples in less than one day.	Formaldehyde	89-97	KRAS proto-oncogene, GTPase	Homo sapiens	71-75
27792253-7	2017	However, Gabra5-/- mice showed prolonged recovery from sensitization in these models, and increased responses in the late phase of the formalin test.	Formaldehyde	135-143	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 5	Mus musculus	9-15
28440440-6	2017	Following the induction of visceral pain by formalin instillation, NK1R in the CSF-CN was upregulated.	Formaldehyde	44-52	tachykinin receptor 1	Rattus norvegicus	67-71
28427201-4	2017	The objective of this study was to analyze UC cases reported in Athens, Ohio and investigate the major components of Wnt5a / planar cell polarity (PCP) signaling pathway in UC human tissue samples and UC cell lines.Formalin fixed and paraffin embedded transurethral resection tissues were immunostained for Wnt5a, Ror-2, CTHRC1 and E-cadherin.	Formaldehyde	215-223	Wnt family member 5A	Homo sapiens	117-122
28549422-4	2017	METHODS: Immunohistochemical staining of pVHL in formalin-fixed, paraffin-embedded sections of cancerous and other tissues from 19 tongue cancer patients showed positivity for LOH of VHL in four samples, negativity in four samples, and was non-informative in 11 samples.	Formaldehyde	49-57	von Hippel-Lindau tumor suppressor	Homo sapiens	41-45
28549422-4	2017	METHODS: Immunohistochemical staining of pVHL in formalin-fixed, paraffin-embedded sections of cancerous and other tissues from 19 tongue cancer patients showed positivity for LOH of VHL in four samples, negativity in four samples, and was non-informative in 11 samples.	Formaldehyde	49-57	von Hippel-Lindau tumor suppressor	Homo sapiens	42-45
28391847-10	2017	For concentrations at or above 11.3gL-1 of hydrogen peroxide and 10mgL-1 of formaldehyde, the probability of giving a negative output was also lower than 5%.	Formaldehyde	76-88	LLGL scribble cell polarity complex component 1	Homo sapiens	67-72
28343305-7	2017	The presence of MECT1-MAML2 was evaluated with reverse transcription polymerase chain reaction using RNA extracted from formalin-fixed paraffin-embedded tumor tissue.	Formaldehyde	120-128	CREB regulated transcription coactivator 1	Homo sapiens	16-21
28343305-7	2017	The presence of MECT1-MAML2 was evaluated with reverse transcription polymerase chain reaction using RNA extracted from formalin-fixed paraffin-embedded tumor tissue.	Formaldehyde	120-128	mastermind like transcriptional coactivator 2	Homo sapiens	22-27
27802183-2	2017	The presence of FGFR2 amplification was assessed in formalin-fixed, paraffin-embedded tissues using a quantitative PCR-based gene copy number assay with advanced gastric cancer cohorts.	Formaldehyde	52-60	fibroblast growth factor receptor 2	Homo sapiens	16-21
28085175-5	2017	Cathepsin K was evaluated on formalin-fixed and paraffin-embedded tissue microarrays with 5 tissue spots per case.	Formaldehyde	29-37	cathepsin K	Homo sapiens	0-11
28339008-5	2017	In addition, SNAP25 was detected in a very low number of MB cells as shown by western blot analysis and immunohistochemical analyses of archived and formalin-fixed/paraffin-embedded human MB specimens.	Formaldehyde	149-157	synaptosome associated protein 25	Homo sapiens	13-19
26657878-10	2017	These results suggest that these antibodies are reliable and reproducible tools for immunohistochemistry analysis of ER and PR expression levels in formalin-fixed and paraffin-embedded breast carcinoma tissues on the Dako Omnis platform.	Formaldehyde	148-156	progesterone receptor	Homo sapiens	124-126
28285942-0	2017	Small molecule inhibitors of PSD95-nNOS protein-protein interactions suppress formalin-evoked Fos protein expression and nociceptive behavior in rats.	Formaldehyde	78-86	discs large MAGUK scaffold protein 4	Rattus norvegicus	29-34
28285942-0	2017	Small molecule inhibitors of PSD95-nNOS protein-protein interactions suppress formalin-evoked Fos protein expression and nociceptive behavior in rats.	Formaldehyde	78-86	nitric oxide synthase 1	Rattus norvegicus	35-39
28285942-0	2017	Small molecule inhibitors of PSD95-nNOS protein-protein interactions suppress formalin-evoked Fos protein expression and nociceptive behavior in rats.	Formaldehyde	78-86	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	94-97
28285942-6	2017	We examined the impact of small molecule PSD95-nNOS protein-protein interaction inhibitors (ZL006, IC87201) on both nociceptive behavior and formalin-evoked Fos protein expression within the lumbar spinal cord of rats.	Formaldehyde	141-149	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	157-160
28285942-8	2017	IC87201 and ZL006, but not ZL007, suppressed phase 2 of formalin-evoked pain behavior and decreased the number of formalin-induced Fos-like immunoreactive cells in spinal dorsal horn regions associated with nociceptive processing.	Formaldehyde	114-122	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	131-134
28282036-3	2017	During in vitro differentiation of normal human uro-epithelial cells, formaldehyde-assisted isolation of regulatory elements (FAIRE-seq) and RNA-seq was used to identify alterations in chromatin accessibility and gene expression changes following activation of the nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma) as a differentiation-initiating event.	Formaldehyde	70-82	peroxisome proliferator activated receptor gamma	Homo sapiens	332-341
28251688-0	2017	Inhibition of ALDH2 protects PC12 cells against formaldehyde-induced cytotoxicity: involving the protection of hydrogen sulphide.	Formaldehyde	48-60	aldehyde dehydrogenase 1 family, member A1	Rattus norvegicus	14-19
28375637-8	2017	In particular, Formaldehyde Probe 573 (FAP573), based on a resorufin scaffold, is the most red-shifted and FA sensitive in this series in terms of signal-to-noise responses and enables identification of alcohol dehydrogenase 5 (ADH5) as an enzyme that regulates FA metabolism in living cells.	Formaldehyde	15-27	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	203-226
28128276-5	2017	We performed whole gene expression analysis of formalin-fixed paraffin-embedded tissue from sarcomatoid mesothelioma and lung sarcomatoid carcinoma and observed significant differences in the expression of MUC4 and other genes between sarcomatoid mesothelioma and lung sarcomatoid carcinoma.	Formaldehyde	47-55	mucin 4, cell surface associated	Homo sapiens	206-210
28181685-11	2017	In RT-qPCR analysis, mRNA expression of NGF, P2X2, and TRPA1 receptors was significantly increased in the bladder mucosa, and mRNA expression of TNF-alpha, iNOS and COX2 in the ventral lobes of prostate was significantly increased in formalin-vehicle rats compared with sham-saline rats (P &lt; 0.05).	Formaldehyde	234-242	nerve growth factor	Rattus norvegicus	40-43
28181685-12	2017	In addition, relative mRNA expression ratio of ERbeta to ERalpha (ERbeta/ERalpha) in the ventral lobes of prostate was significantly decreased in formalin-vehicle rats compared with sham-saline rats (P &lt; 0.05).	Formaldehyde	146-154	estrogen receptor 2	Rattus norvegicus	47-53
28181685-12	2017	In addition, relative mRNA expression ratio of ERbeta to ERalpha (ERbeta/ERalpha) in the ventral lobes of prostate was significantly decreased in formalin-vehicle rats compared with sham-saline rats (P &lt; 0.05).	Formaldehyde	146-154	estrogen receptor 1	Rattus norvegicus	57-64
28181685-12	2017	In addition, relative mRNA expression ratio of ERbeta to ERalpha (ERbeta/ERalpha) in the ventral lobes of prostate was significantly decreased in formalin-vehicle rats compared with sham-saline rats (P &lt; 0.05).	Formaldehyde	146-154	estrogen receptor 2	Rattus norvegicus	66-72
28181685-12	2017	In addition, relative mRNA expression ratio of ERbeta to ERalpha (ERbeta/ERalpha) in the ventral lobes of prostate was significantly decreased in formalin-vehicle rats compared with sham-saline rats (P &lt; 0.05).	Formaldehyde	146-154	estrogen receptor 1	Rattus norvegicus	73-80
28452367-2	2017	Herein, we report that diolefin-ruthenium complexes containing the chemically and redox non-innocent ligand trop2dad catalyse the production of H2 from formaldehyde and water in the presence of a base.	Formaldehyde	152-164	tumor associated calcium signal transducer 2	Homo sapiens	108-113
28375637-8	2017	In particular, Formaldehyde Probe 573 (FAP573), based on a resorufin scaffold, is the most red-shifted and FA sensitive in this series in terms of signal-to-noise responses and enables identification of alcohol dehydrogenase 5 (ADH5) as an enzyme that regulates FA metabolism in living cells.	Formaldehyde	15-27	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	228-232
28124285-4	2017	METHODS: We used fluorescence in situ hybridization targeting FGD5 and chromosome 3 centromere (CEP3) on formalin-fixed, paraffin-embedded tissue from 430 primary breast cancers and 108 lymph node metastases, from a cohort of Norwegian breast cancer patients.	Formaldehyde	105-113	CDC42 effector protein 3	Homo sapiens	96-100
28224790-1	2017	The photodeprotection of formaldehyde was investigated for 3-(1-hydroxypropan-2-yl)benzophenone (3-HPBP) with ultrafast time-resolved spectroscopy.	Formaldehyde	25-37	HPBP	Homo sapiens	99-103
26657872-5	2017	METHODS: Protein expression of HMGA1 and HMGA2 in 80 formalin-fixed retinoblastoma tissues was performed by immunohistochemistry, and their mRNA expressions were analyzed on 40 fresh primary enucleated retinoblastoma samples by semiquantitative reverse transcription polymerase chain reaction.	Formaldehyde	53-61	high mobility group AT-hook 1	Homo sapiens	31-36
26657872-5	2017	METHODS: Protein expression of HMGA1 and HMGA2 in 80 formalin-fixed retinoblastoma tissues was performed by immunohistochemistry, and their mRNA expressions were analyzed on 40 fresh primary enucleated retinoblastoma samples by semiquantitative reverse transcription polymerase chain reaction.	Formaldehyde	53-61	high mobility group AT-hook 2	Homo sapiens	41-46
28130756-0	2017	Comparison of Five Different Assays for the Detection of BRAF Mutations in Formalin-Fixed Paraffin Embedded Tissues of Patients with Metastatic Melanoma.	Formaldehyde	75-83	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	57-61
28145034-4	2017	The new method only requires three reagents (silver nitrate, sodium hydroxide, and formaldehyde) and 6-7 min with high detection sensitivity to visualize as low as 14.6 pg (3.3 pg/mm2 ) of DNA in a non-denaturing polyacrylamide gel.	Formaldehyde	83-95	PNMA family member 2	Homo sapiens	180-183
28363612-4	2017	METHODS: Immunohistochemical staining of PD-L1 expression was performed in sections of 174 Formalin-fixed paraffin-embedded (FFPE) tissue blocks from surgery removed thyroid nodules.	Formaldehyde	91-99	CD274 molecule	Homo sapiens	41-46
26919893-5	2017	Methods The feline androgen receptor gene was characterised and used to test clonality of feline lymphomas by PCR and polyacrylamide gel electrophoresis, using archival formalin-fixed, paraffin-embedded material.	Formaldehyde	169-177	androgen receptor	Homo sapiens	19-36
28228507-2	2017	Folate-independent pathways are mediated by cytosolic alcohol dehydrogenase 5 (ADH5) and mitochondrial aldehyde dehydrogenase 2 (ALDH2), which generate formate by oxidizing formaldehyde.	Formaldehyde	173-185	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	54-77
28228507-2	2017	Folate-independent pathways are mediated by cytosolic alcohol dehydrogenase 5 (ADH5) and mitochondrial aldehyde dehydrogenase 2 (ALDH2), which generate formate by oxidizing formaldehyde.	Formaldehyde	173-185	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	79-83
28228507-2	2017	Folate-independent pathways are mediated by cytosolic alcohol dehydrogenase 5 (ADH5) and mitochondrial aldehyde dehydrogenase 2 (ALDH2), which generate formate by oxidizing formaldehyde.	Formaldehyde	173-185	aldehyde dehydrogenase 2 family member	Homo sapiens	129-134
28130756-4	2017	METHODS: In our study, we assessed and compared BRAF mutations in 59 formalin-fixed and paraffin-embedded tumor samples of patients with metastatic melanoma with next-generation sequencing (NGS), Cobas  4800 BRAF V600 mutation test CE-IVD commercial kit, high-resolution melting PCR (HRM), multiplex real-time allele specific amplification (multiplexed RT-ASA) and immunohistochemistry (IHC).	Formaldehyde	69-77	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	48-52
28454397-4	2017	Therefore, the expression of Sphk1 was examined in 127 formalin-fixed, paraffin-embedded HCC tissues using immunohistochemistry, and its clinical implications and prognostic significance were analyzed.	Formaldehyde	55-63	sphingosine kinase 1	Homo sapiens	29-34
28260090-5	2017	Immunohistochemical analyses of osteosarcoma tissue samples from two independent cohorts of formaldehyde-fixed, paraffin-embedded osteosarcoma tissue samples from total of 186 osteosarcoma patients showed that high ACTL6A expression correlated with malignant clinicopathological features such as larger tumor size, high Ennecking grade, high histologic grade, and advanced tumor node metastasis stage.	Formaldehyde	92-104	actin like 6A	Homo sapiens	215-221
28447972-4	2017	Sequencing artifacts associated with deamination events commonly found in formalin fixed paraffin embedded tissues can be partially remedied by the use of uracil DNA glycosylase during extraction steps.	Formaldehyde	74-82	uracil DNA glycosylase	Homo sapiens	155-177
28438981-3	2017	In vivo, peripheral administration of the selective GABAA receptor agonist muscimol evoked spontaneous licking behavior, as well as spinal wide dynamic range (WDR) neuron firing, after pre-conditioning with formalin but had no effect in saline-treated mice.	Formaldehyde	207-215	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	52-57
28438981-4	2017	GABAA receptor-mediated pain behavior after acute formalin treatment was abolished by the GABAA receptor blocker picrotoxin and cyclooxygenase inhibitor indomethacin.	Formaldehyde	50-58	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	0-5
28438981-4	2017	GABAA receptor-mediated pain behavior after acute formalin treatment was abolished by the GABAA receptor blocker picrotoxin and cyclooxygenase inhibitor indomethacin.	Formaldehyde	50-58	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	90-95
28438981-7	2017	Both formalin and PGE2 potentiated GABA-induced Ca2+ transients and membrane depolarization in capsaicin-sensitive nociceptive DRG neurons; these effects were blocked by the prostaglandin E2 receptor 4 (EP4) antagonist AH23848 (10 mumol/L).	Formaldehyde	5-13	prostaglandin E receptor 4 (subtype EP4)	Mus musculus	203-206
28079226-3	2017	Computationally predicted products of RDX hydrolysis such as nitrite, nitrous oxide, formaldehyde, formate, and ammonia correspond to experimentally observed ones.	Formaldehyde	85-97	radixin	Homo sapiens	38-41
28039034-3	2017	In the current study, we explored the use of quantitative real time reverse transcription-PCR (RT-qPCR) as a potential method for the accurate relative quantification of the HER2 gene using formalin fixed paraffin embedded (FFPE) breast cancer biopsy samples.	Formaldehyde	190-198	erb-b2 receptor tyrosine kinase 2	Homo sapiens	174-178
28331615-5	2017	Expression of IRF-1 and PD-L1 in archival pre-treatment formalin-fixed, paraffin-embedded tumor samples were assessed by the AQUA method of quantitative immunofluorescence.	Formaldehyde	56-64	interferon regulatory factor 1	Homo sapiens	14-19
28401199-2	2017	The protein expression levels of epithelial cell adhesion molecule (EpCAM) and epidermal growth factor receptor (EGFR) were evaluated by immunohistochemistry in formalin-fixed paraffin-embedded specimens from 30 patients with epithelial ovarian carcinoma and 15 normal ovary tissues.	Formaldehyde	161-169	epithelial cell adhesion molecule	Homo sapiens	33-66
28270146-6	2017	Correlations between expression of CK2alpha and BMI1 were determined from cell lines and formalin fixed paraffin embedded tissues representing the normal fallopian tube epithelium and high grade serous ovarian cancer samples.	Formaldehyde	89-97	casein kinase 2 alpha 2	Homo sapiens	35-43
29120119-2	2017	Immunohistochemistry was performed on formalin-fixed, paraffin-embeddedtissue by the RET, p27 and cyclin D1 antibodies.	Formaldehyde	38-46	ret proto-oncogene	Homo sapiens	85-88
28089665-11	2017	Lastly, formalin-induced cFos expression and the effects of systemic morphine were examined in the superficial dorsal horn of the spinal cord.	Formaldehyde	8-16	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	25-29
28089665-12	2017	Intraplantar formalin produced robust expression of cFos; however, morphine did not attenuate the cFos expression.	Formaldehyde	13-21	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	52-56
28233679-5	2017	The role of CaV3.2 in pain modulation was supported by demonstrating selective antisense oligonucleotide-mediated CaV3.2 knockdown, in vivo antinociceptive effects of T-type blockers, and pain attenuation in CaV3.2 knockout formalin-induced pain model.	Formaldehyde	224-232	calcium channel, voltage-dependent, T type, alpha 1H subunit	Mus musculus	12-18
27543599-3	2017	AIMS: A novel, fully automated real-time PCR-based Idylla test is assessed to detect the BRAF mutation in formalin-fixed paraffin-embedded (FFPE) thyroid samples.	Formaldehyde	106-114	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	89-93
28096238-7	2017	Interestingly, immunofluorescence labeling performed on formalin-fixed paraffin-embedded prostate tissues showed an exclusive expression of the TRPA1 channel in prostate cancer stromal cells.	Formaldehyde	56-64	transient receptor potential cation channel subfamily A member 1	Homo sapiens	144-149
27778364-10	2017	This case shows the utility of adipophilin immunostaining to prove the lipid contents in neoplastic cells, which has the advantage of using formalin-fixed paraffin-embedded tissue and making needless frozen sections and ultrastructural studies to show these findings.	Formaldehyde	140-148	perilipin 2	Homo sapiens	31-42
28073897-0	2017	Identification of ALK, ROS1, and RET Fusions by a Multiplexed mRNA-Based Assay in Formalin-Fixed, Paraffin-Embedded Samples from Advanced Non-Small-Cell Lung Cancer Patients.	Formaldehyde	82-90	ALK receptor tyrosine kinase	Homo sapiens	18-21
28073897-0	2017	Identification of ALK, ROS1, and RET Fusions by a Multiplexed mRNA-Based Assay in Formalin-Fixed, Paraffin-Embedded Samples from Advanced Non-Small-Cell Lung Cancer Patients.	Formaldehyde	82-90	ret proto-oncogene	Homo sapiens	33-36
28183025-0	2017	Melamine and/or formaldehyde exposures affect steroidogenesis via alteration of StAR protein and testosterone synthetic enzyme expression in male mice.	Formaldehyde	16-28	steroidogenic acute regulatory protein	Mus musculus	80-84
27940396-4	2017	Expression of KISS-1 protein was analyzed immunohistochemically in formalin-fixed, paraffin-embedded adenomyotic tissue specimens (n=29), matched eutopic endometrium from the same patients (n=29) and normal endometrium from patients without adenomyosis (n=29).	Formaldehyde	67-75	KiSS-1 metastasis suppressor	Homo sapiens	14-20
28031403-4	2017	Previous work has shown that knockout of GFRalpha2 alters heat, but not mechanical, responses in dissociated sensory neurons and reduces pain-related behaviors during the second phase of the formalin test.	Formaldehyde	191-199	glial cell line derived neurotrophic factor family receptor alpha 2	Mus musculus	41-50
26846362-0	2017	Liver X Receptor beta Is Involved in Formalin-Induced Spontaneous Pain.	Formaldehyde	37-45	nuclear receptor subfamily 1, group H, member 2	Mus musculus	0-21
26846362-4	2017	This increased reactivity to inflammatory pain was accompanied by enhanced formalin-evoked Fos and pERK staining of second-order nociceptive neurons.	Formaldehyde	75-83	FBJ osteosarcoma oncogene	Mus musculus	91-94
26846362-4	2017	This increased reactivity to inflammatory pain was accompanied by enhanced formalin-evoked Fos and pERK staining of second-order nociceptive neurons.	Formaldehyde	75-83	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	99-103
26846362-5	2017	Immunohistochemistry showed that the expression of CGRP, SP, and IB4 was increased in the lamina I-II of the lumbar dorsal horns in formalin-injected LXRbeta knockout (KO) mice compared with the WT controls.	Formaldehyde	132-140	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	51-55
26846362-5	2017	Immunohistochemistry showed that the expression of CGRP, SP, and IB4 was increased in the lamina I-II of the lumbar dorsal horns in formalin-injected LXRbeta knockout (KO) mice compared with the WT controls.	Formaldehyde	132-140	nuclear receptor subfamily 1, group H, member 2	Mus musculus	150-157
26846362-6	2017	In addition, LXRbeta deletion in the mice enhanced the formalin-induced inflammation with more activated microglia and astrocytes in the spinal cord.	Formaldehyde	55-63	nuclear receptor subfamily 1, group H, member 2	Mus musculus	13-20
26846362-7	2017	Furthermore, the levels of pro-inflammatory cytokines (IL-1beta ,TNF-alpha) as well as NFkappaB in the formalin-injected paw were elevated by the loss of LXRbeta.	Formaldehyde	103-111	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	87-95
26846362-7	2017	Furthermore, the levels of pro-inflammatory cytokines (IL-1beta ,TNF-alpha) as well as NFkappaB in the formalin-injected paw were elevated by the loss of LXRbeta.	Formaldehyde	103-111	nuclear receptor subfamily 1, group H, member 2	Mus musculus	154-161
28201998-0	2017	Clinical performance evaluation of a sensitive, rapid low-throughput test for KRAS mutation analysis using formalin-fixed, paraffin-embedded tissue samples.	Formaldehyde	107-115	KRAS proto-oncogene, GTPase	Homo sapiens	78-82
28280347-4	2017	METHODS: The expression of ALDOA was detected using immunohistochemical staining in 162 formalin-fixed, paraffin-embedded ccRCC sections.	Formaldehyde	88-96	aldolase, fructose-bisphosphate A	Homo sapiens	27-32
28201998-1	2017	BACKGROUND: Testing for KRAS mutations in metastatic colorectal cancer (mCRC) on formalin-fixed, paraffin embedded (FFPE) tumor tissue has become standard of care.	Formaldehyde	81-89	KRAS proto-oncogene, GTPase	Homo sapiens	24-28
27916440-8	2017	Pharmacological blockade of PPARgamma in the lPAG enhanced formalin-evoked nociceptive behaviour in WKY, but not SD, rats.	Formaldehyde	59-67	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	28-37
28135061-8	2017	Third, we show that routinely fixed post-mortem human brain can be analyzed by isolating parvalbumin-containing neurons from cortical samples that were fixed for periods of up to 8 weeks in formalin.	Formaldehyde	190-198	parvalbumin	Homo sapiens	89-100
28095324-9	2017	Spinal nerve injury and 2-5%, but not 1%, formalin injection enhanced ATF3 protein expression and immunofluorescence in dorsal root ganglia (DRG) in a time-dependent manner.	Formaldehyde	42-50	activating transcription factor 3	Homo sapiens	70-74
28063353-1	2017	Based on structure activity analysis of morphine related opiates, we have synthesized some novel benzopyran fused isoxazolidines (2a-e) and derived conformationally constrained beta2,3,3-amino alcohols (3a-e), which were evaluated in vivo for their anti-nociceptive activity through acetic acid induced writhing test (peripheral) and formalin induced algesia (central).	Formaldehyde	334-342	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	177-182
27916440-3	2017	This study characterised PPAR signalling in the PAG of WKY rats exposed to the formalin test of inflammatory pain, versus Sprague-Dawley (SD) controls.	Formaldehyde	79-87	peroxisome proliferator activated receptor alpha	Rattus norvegicus	25-29
27916440-4	2017	Formalin injection reduced levels of the endogenous PPAR ligands N-palmitoylethanolamide (PEA) and N-oleoylethanolamide (OEA) in the lateral(l) PAG of SD rats, but not WKY rats which exhibited higher levels of these analytes compared with formalin-injected SD counterparts.	Formaldehyde	0-8	peroxisome proliferator activated receptor alpha	Rattus norvegicus	52-56
27916440-6	2017	PPARgamma mRNA and protein levels in the lPAG were higher in saline-treated WKY rats, with PPARgamma protein levels reduced by formalin treatment in WKY rats only.	Formaldehyde	127-135	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	0-9
27916440-6	2017	PPARgamma mRNA and protein levels in the lPAG were higher in saline-treated WKY rats, with PPARgamma protein levels reduced by formalin treatment in WKY rats only.	Formaldehyde	127-135	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	91-100
28104429-0	2017	Using lysine adducts of human serum albumin to investigate the disposition of exogenous formaldehyde in human blood.	Formaldehyde	88-100	albumin	Homo sapiens	30-43
28104429-2	2017	To investigate whether exogenous formaldehyde produces adducts in extracellular fluids, we characterized modifications to human serum albumin (HSA) following incubation of whole blood, plasma, and saliva with formaldehyde at concentrations of 1, 10 and 100muM.	Formaldehyde	209-221	albumin	Homo sapiens	128-141
27767231-4	2017	Our smMIP-based NGS approach provides analysis of both strands of the open reading frame of BRCA1 and BRCA2, enabling the discrimination between real variants and formalin-induced artefacts.	Formaldehyde	163-171	BRCA1 DNA repair associated	Homo sapiens	92-97
28579665-1	2017	Immunohistochemical detection of FOXP3 antigen is a usable marker for detection of regulatory T lymphocytes (TR) in formalin fixed and paraffin embedded sections of different types of tumor tissue.	Formaldehyde	116-124	forkhead box P3	Homo sapiens	33-38
27628324-6	2017	DESIGN: -Formalin-fixed, paraffin-embedded tissue microarrays consisting of normal tissues and various neoplastic tissues were immunohistochemically evaluated with mASH1.	Formaldehyde	9-17	achaete-scute family bHLH transcription factor 1	Mus musculus	164-169
28039535-4	2017	METHODS: In this study, we used ddPCR to measure the HER2 gene copy number in clinical formalin-fixed paraffin-embedded samples of 41 primary breast cancer patients.	Formaldehyde	87-95	erb-b2 receptor tyrosine kinase 2	Homo sapiens	53-57
28052410-8	2017	IgG4 and C3d immunohistochemistry could replace DIF in almost all of our cases, so before doing DIF, reliable immunohistochemical detection of IgG4 and C3d on formalin-fixed tissue is advised to be done.	Formaldehyde	159-167	endogenous retrovirus group K member 13	Homo sapiens	152-155
27767231-4	2017	Our smMIP-based NGS approach provides analysis of both strands of the open reading frame of BRCA1 and BRCA2, enabling the discrimination between real variants and formalin-induced artefacts.	Formaldehyde	163-171	BRCA2 DNA repair associated	Homo sapiens	102-107
27081897-4	2017	METHODS mRNA expression of ACTC1 expression was analyzed using quantitative real-time polymerase chain reaction (qRT-PCR) in 47 formalin-fixed, paraffin-embedded glioma tissues that were graded according to WHO criteria: Grade I (n = 4); Grade II (n = 12); Grade III (n = 6); and Grade IV (n = 25).	Formaldehyde	128-136	actin alpha cardiac muscle 1	Homo sapiens	27-32
28356966-4	2017	In the present study, immunohistochemical analysis of Fer was performed using the formalin-fixed tissue samples of 152 patients with RCC.	Formaldehyde	82-90	FER tyrosine kinase	Homo sapiens	54-57
27667773-5	2017	METHODS: Bristol-Myers Squibb and Dako previously reported on an automated PD-L1 immunohistochemical (IHC) assay that detects cell surface PD-L1 in formalin-fixed, paraffin-embedded, human tumor tissue specimens using Dako"s Autostainer Link 48.	Formaldehyde	148-156	CD274 molecule	Homo sapiens	75-80
27667773-5	2017	METHODS: Bristol-Myers Squibb and Dako previously reported on an automated PD-L1 immunohistochemical (IHC) assay that detects cell surface PD-L1 in formalin-fixed, paraffin-embedded, human tumor tissue specimens using Dako"s Autostainer Link 48.	Formaldehyde	148-156	CD274 molecule	Homo sapiens	139-144
28218046-5	2017	Thyroid transcription factor 1 expression was assessed using indirect immunohistochemical detection in formalin-fixed paraffin-embedded tumour tissue at the time of diagnosis.	Formaldehyde	103-111	NK2 homeobox 1	Homo sapiens	0-30
28222662-4	2017	Formalin-fixed, paraffin-embedded esophageal squamous cell carcinoma tissues of 135 esophageal squamous cell carcinoma patients were detected for FOXF2 promoter methylation status by methylation-specific polymerase chain reaction approach.	Formaldehyde	0-8	forkhead box F2	Homo sapiens	146-151
27687309-5	2017	We applied mass spectrometry-based proteomic analysis to quantify HER2 protein expression in formalin-fixed tumor samples.	Formaldehyde	93-101	erb-b2 receptor tyrosine kinase 2	Homo sapiens	66-70
28234619-8	2017	The GPx  activity and GSH level decreased by formalin exposures and did not return to the control values during recovery periods.	Formaldehyde	45-53	glutathione peroxidase 1	Oncorhynchus mykiss	4-7
28074045-3	2017	MATERIAL AND METHODS The expression of SDF-1and NF-kappaB in 105 formalin-fixed, paraffin-embedded cervical cancer tissues and the adjacent tissues was examined by immunohistochemistry (IHC).	Formaldehyde	65-73	C-X-C motif chemokine ligand 12	Homo sapiens	39-44
28036291-0	2017	Assessing the clinical value of microRNAs in formalin-fixed paraffin-embedded liposarcoma tissues: Overexpressed miR-155 is an indicator of poor prognosis.	Formaldehyde	45-53	microRNA 155	Homo sapiens	113-120
28068934-3	2017	METHODS: We examined five hotspot mutations in the PIK3CA gene (E542K, E545K, E546K, H1047R, and H1047L) in formalin-fixed and paraffin-embedded tissue sections of paired endoscopic biopsy and surgically resected specimens from 181 patients undergoing curative resection for ESCC between 2000 and 2011 using a Luminex technology-based multiplex gene mutation detection kit.	Formaldehyde	108-116	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	51-57
29109756-2	2017	Utilizing a condensation reaction between carbonyls and a hydrazine moeity, we demonstrate that the fluorescent probe (Aldehydefluor-1) AF1 reacts with a range of reactive carbonyl species including formaldehyde, acetaldehyde, glyoxylic acid, and methyl glyoxal.	Formaldehyde	199-211	interferon gamma receptor 2	Homo sapiens	136-139
28814085-3	2017	METHODS: The immunostaining status of ADAMTS1,8, and 18 were investigated in formalin-fixed paraffin-embedded samples of 25 patients who underwent curative resection for GC.	Formaldehyde	77-85	ADAM metallopeptidase with thrombospondin type 1 motif 1	Homo sapiens	38-45
27574810-8	2017	All 4 PUTIPs with formalin-fixed, paraffin-embedded material available were positive for the TERT promoter mutation 228G&gt;A by polymerase chain reaction and were microsatellite stable.	Formaldehyde	18-26	telomerase reverse transcriptase	Homo sapiens	93-97
28819937-3	2017	MATERIAL AND METHODS: In this study, we investigated A5935G, G5949A, G6081A, G6267A mutations in MT-CO1 and T9540C in MT-CO3, and alterations detected during the analysis of MT-CO gene fragments in formalin-fixed, paraffin-embedded endometrial and benign endometrial hyperplasia of a cohort of 125 subjects.	Formaldehyde	198-206	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	97-103
28529880-12	2017	The PR concordance rate was 45.2% for CBs fixed in formalin and 70.6% for those fixed with CytoLyt  (p=0.047).	Formaldehyde	51-59	progesterone receptor	Homo sapiens	4-6
29199691-6	2017	Detection of ALK fusion was done by IHC on formalin fixed paraffin embedded cell blocks.	Formaldehyde	43-51	ALK receptor tyrosine kinase	Homo sapiens	13-16
29199726-7	2017	BRAF V600E mutation analysis was done by real time polymerase chain reaction after extracting genomic DNA from the representative archived formalin fixed paraffin embedded tumor tissue.	Formaldehyde	139-147	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	0-4
27707590-7	2017	We established LINC00518 and PRAME in both adhesive patch melanoma samples and underlying formalin fixed paraffin embedded (FFPE) samples of surgically excised primary melanomas and in melanoma lymph node metastases.	Formaldehyde	90-98	PRAME nuclear receptor transcriptional regulator	Homo sapiens	29-34
27802225-6	2017	Both semicarbazide-sensitive amine oxidase (SSAO, a formaldehyde-generating enzyme) and formaldehyde levels in the blood and urine were analyzed by using an enzyme-linked immunosorbent assay (ELISA) and HPLC, respectively.	Formaldehyde	52-64	amine oxidase copper containing 2	Homo sapiens	44-48
27802225-9	2017	The results of biochemical analysis revealed that the observed increase in urine formaldehyde resulted from an overexpression of SSAO in the blood.	Formaldehyde	81-93	amine oxidase copper containing 2	Homo sapiens	129-133
28155154-2	2017	As a stress response mechanism, it may also be involved in cellular response to therapy.LC3 and Sequestosome 1 (p62/SQSTM1) are among the most widely used markers to monitor autophagy, and can be visualized in formalin-fixed and paraffin-embedded tissue by immunohistochemistry.	Formaldehyde	210-218	sequestosome 1	Homo sapiens	112-115
27032393-8	2017	SLFN5 expression was also determined by immunohistochemistry in formalin-fixed paraffin-embedded samples from individuals with non-atrophic gastritis, atrophic gastritis, complete IM, incomplete IM, and GC, respectively.	Formaldehyde	64-72	schlafen family member 5	Homo sapiens	0-5
27629500-6	2017	Behavioral tests demonstrated that KA-2 induced larger amelioration of formalin-evoked alterations as compared with KA-1 and the assessment of c-Fos immunoreactivity in the TNC yielded similar results.	Formaldehyde	71-79	glutamate ionotropic receptor kainate type subunit 5	Rattus norvegicus	35-39
29629425-4	2017	The first approach involved identification of patient-specific genomic EWSR1 fusion breakpoints in formalin-fixed, paraffin-embedded tumor DNA using a broad, hybridization capture-based next generation sequencing (NGS) panel, followed by design of patient-specific droplet digital PCR (ddPCR) assays for plasma cfDNA interrogation .	Formaldehyde	99-107	EWS RNA binding protein 1	Homo sapiens	71-76
28901323-0	2017	Human epidermal growth factor receptor 2 amplification detection by droplet digital polymerase chain reaction in formalin-fixed paraffin-embedded breast and gastric cancer samples.	Formaldehyde	113-121	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-40
28752453-4	2017	Here, we describe a highly sensitive method to detect the AAT antigen in formalin-fixed paraffin-embedded human or mouse tissues.	Formaldehyde	73-81	serpin family A member 1	Homo sapiens	58-61
28155154-2	2017	As a stress response mechanism, it may also be involved in cellular response to therapy.LC3 and Sequestosome 1 (p62/SQSTM1) are among the most widely used markers to monitor autophagy, and can be visualized in formalin-fixed and paraffin-embedded tissue by immunohistochemistry.	Formaldehyde	210-218	sequestosome 1	Homo sapiens	96-110
28155154-2	2017	As a stress response mechanism, it may also be involved in cellular response to therapy.LC3 and Sequestosome 1 (p62/SQSTM1) are among the most widely used markers to monitor autophagy, and can be visualized in formalin-fixed and paraffin-embedded tissue by immunohistochemistry.	Formaldehyde	210-218	sequestosome 1	Homo sapiens	116-122
28326936-5	2017	In the formalin footpad model, systemic treatment with GCPII inhibitors reduces both phases of the inflammatory pain response and increases release of spinal noradrenaline.	Formaldehyde	7-15	folate hydrolase 1	Homo sapiens	55-60
27734382-6	2017	Here, we describe a method for visualizing the CCN2 signal as an odontogenic activity in formalin-fixed paraffin-embedded (FFPE) sections of demineralized human teeth and human dental pulp cells.	Formaldehyde	89-97	cellular communication network factor 2	Homo sapiens	47-51
27734400-4	2017	This chapter describes a detailed in situ hybridization technique for the detection of CCN1 and CCN5 in formalin-fixed, paraffin-embedded patient samples of breast and pancreatic cancers.	Formaldehyde	104-112	cellular communication network factor 1	Homo sapiens	87-91
27734400-4	2017	This chapter describes a detailed in situ hybridization technique for the detection of CCN1 and CCN5 in formalin-fixed, paraffin-embedded patient samples of breast and pancreatic cancers.	Formaldehyde	104-112	cellular communication network factor 5	Homo sapiens	96-100
28123555-3	2017	HO-1 expression was evaluated using immunohistochemistry in 147 formalin-fixed tissue specimens.	Formaldehyde	64-72	heme oxygenase 1	Homo sapiens	0-4
28043154-3	2017	Immunohistochemical detection of AIF expression in formalin fixed and in paraffin embedded tissue samples was evaluated semiquantitatively, intensity and percentage multiplicative Quick Score (QS) was calculated and compared between patients with over 5 year (n=32) and less than 5 year (n=22) survival.	Formaldehyde	51-59	apoptosis inducing factor mitochondria associated 1	Homo sapiens	33-36
28969472-6	2017	Pre-emptive propofol reduced pain with a delayed response to formalin and a reduction in hypersensitivity that lasted at least for 2 h. The formalin-induced activation of spinal GluN2B and ERK1/2 but not p38 or c-Jun N-terminal kinase was also diminished by propofol treatment.	Formaldehyde	140-148	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	178-184
28969472-6	2017	Pre-emptive propofol reduced pain with a delayed response to formalin and a reduction in hypersensitivity that lasted at least for 2 h. The formalin-induced activation of spinal GluN2B and ERK1/2 but not p38 or c-Jun N-terminal kinase was also diminished by propofol treatment.	Formaldehyde	140-148	mitogen activated protein kinase 3	Rattus norvegicus	189-195
28969472-8	2017	Propofol also reduced the neuronal expression of c-Fos and p-ERK induced by formalin.	Formaldehyde	76-84	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	49-54
27544315-0	2017	Clinical Usefulness of a One-Tube Nested Reverse Transcription Quantitative Polymerase Chain Reaction Assay for Evaluating Human Epidermal Growth Factor Receptor 2 mRNA Overexpression in Formalin-Fixed and Paraffin-Embedded Breast Cancer Tissue Samples.	Formaldehyde	187-195	erb-b2 receptor tyrosine kinase 2	Homo sapiens	123-163
28012880-4	2017	We also used immunohistochemistry to analyze KIAA1199 protein expression in formalin-fixed, paraffin-embedded tissues from 98 patients with PDAC.	Formaldehyde	76-84	cell migration inducing hyaluronidase 1	Homo sapiens	45-53
27544315-3	2017	METHODS: In this study, we analyzed HER2 mRNA expression in clinical formalin-fixed and paraffin-embedded (FFPE) samples using a one-tube nested reverse transcription quantitative polymerase chain reaction (RT-qPCR) assay.	Formaldehyde	69-77	erb-b2 receptor tyrosine kinase 2	Homo sapiens	36-40
29358995-5	2017	Material and methods: The immunostaining status of ADAMTS1, 8, 9, and 18 were investigated in formalin-fixed paraffin-embedded samples of 25 patients who underwent pancreaticoduodenectomy for an adenocarcinoma located at the head of the pancreas.	Formaldehyde	94-102	ADAM metallopeptidase with thrombospondin type 1 motif 1	Homo sapiens	51-58
27930669-3	2016	In this study, we developed a novel RNA-FISH assay using branched DNA probe to detect FGFR3-TACC3 fusions in formaldehyde-fixed paraffin-embedded (FFPE) human BC samples.	Formaldehyde	109-121	fibroblast growth factor receptor 3	Homo sapiens	86-91
27873521-1	2017	Although formaldehyde is well known to cause type 4 hypersensitivity, immunoglobulin E (IgE)-mediated hypersensitivity to formaldehyde is rare.	Formaldehyde	122-134	immunoglobulin heavy constant epsilon	Homo sapiens	70-86
27873521-1	2017	Although formaldehyde is well known to cause type 4 hypersensitivity, immunoglobulin E (IgE)-mediated hypersensitivity to formaldehyde is rare.	Formaldehyde	122-134	immunoglobulin heavy constant epsilon	Homo sapiens	88-91
27873521-6	2017	The level of formaldehyde-specific IgE was high (class 4).	Formaldehyde	13-25	immunoglobulin heavy constant epsilon	Homo sapiens	35-38
27907908-4	2016	BRCA1/2 mutations were identified using next-generation sequencing of formalin-fixed paraffin-embedded tumor samples.	Formaldehyde	70-78	BRCA1 DNA repair associated	Homo sapiens	0-7
27717675-6	2016	The results of the current study in batch condition showed that the best initial pH and ferrate(VI) concentration to obtain the highest formaldehyde removal are 2 and 1 mg/l, respectively.	Formaldehyde	136-148	VPS52 subunit of GARP complex	Homo sapiens	157-168
27934966-4	2016	The FrmR protein is a transcriptional repressor that is specifically inactivated in the presence of formaldehyde, permitting expression of the formaldehyde detoxification machinery (FrmA and FrmB, when the latter is present).	Formaldehyde	100-112	alcohol dehydrogenase class-III	Escherichia coli	182-186
27934966-4	2016	The FrmR protein is a transcriptional repressor that is specifically inactivated in the presence of formaldehyde, permitting expression of the formaldehyde detoxification machinery (FrmA and FrmB, when the latter is present).	Formaldehyde	143-155	alcohol dehydrogenase class-III	Escherichia coli	182-186
28154332-7	2017	Furthermore, the intracerebroventricular injection of DHA or GW9508, which is a selective GPR40/FFA1 agonist, attenuates formalin-induced inflammatory pain behavior through increasing beta-endorphin release in the hypothalamus.	Formaldehyde	121-129	free fatty acid receptor 1	Homo sapiens	90-95
28154332-7	2017	Furthermore, the intracerebroventricular injection of DHA or GW9508, which is a selective GPR40/FFA1 agonist, attenuates formalin-induced inflammatory pain behavior through increasing beta-endorphin release in the hypothalamus.	Formaldehyde	121-129	proopiomelanocortin	Homo sapiens	184-198
27997533-5	2016	Patient-specific TP53 assays were developed for 31 unique mutations identified in formalin-fixed paraffin-embedded tumour DNA from these patients.	Formaldehyde	82-90	tumor protein p53	Homo sapiens	17-21
28031697-5	2017	Formalin-fixed paraffin-embedded tissue section of an ILM-like membrane was submitted for immunohistochemistry with glial fibrillary acidic protein (GFAP).	Formaldehyde	0-8	glial fibrillary acidic protein	Homo sapiens	116-147
27930669-3	2016	In this study, we developed a novel RNA-FISH assay using branched DNA probe to detect FGFR3-TACC3 fusions in formaldehyde-fixed paraffin-embedded (FFPE) human BC samples.	Formaldehyde	109-121	transforming acidic coiled-coil containing protein 3	Homo sapiens	92-97
27929428-4	2016	By immunohistochemistry and fluorescence in-situ hybridization, HER2 expression was investigated in formalin-fixed paraffin-embedded surgical specimens from 90 DTC patients, 45 follicular (FTC) and 45 papillary (PTC) histotypes.	Formaldehyde	100-108	erb-b2 receptor tyrosine kinase 2	Homo sapiens	64-68
27698251-1	2016	Increased expression levels of KCNJ3 have been correlated with lymph node metastases and poor prognosis in patients with breast cancer, suggesting a prognostic role of KCNJ3 We aimed to establish protocols for the detection of KCNJ3 in formalin-fixed, paraffin-embedded (FFPE) breast cancer tissue.	Formaldehyde	236-244	potassium inwardly rectifying channel subfamily J member 3	Homo sapiens	31-36
26791599-0	2016	Tsga10 expression correlates with sperm profiles in the adult formalin-exposed mice.	Formaldehyde	62-70	testis specific 10	Mus musculus	0-6
26791599-2	2016	This study investigates the correlation between sperm profile alterations and Tsga10 gene expression in adult mice exposed to formaldehyde (FA) and then treated with antioxidant effect of manganese (Mn2+ ).	Formaldehyde	126-138	testis specific 10	Mus musculus	78-84
27550342-10	2016	SSEA-1 is a marker that detects malignant thyroid neoplasms in formalin-fixed paraffin-embedded thyroid tissue sections and may be a useful marker for thyroid cancer stem-like cells.	Formaldehyde	63-71	fucosyltransferase 4	Homo sapiens	0-6
27737606-5	2016	Expert commentary: The therascreen  kit is a highly sensitive real-time polymerase chain reaction test that provides standardised testing and automated interpretation of EGFR mutation status in formalin-fixed, paraffin-embedded (FFPE) tissue samples.	Formaldehyde	194-202	epidermal growth factor receptor	Homo sapiens	170-174
27612648-0	2016	Controlled formaldehyde fixation of fibronectin layers for expansion of mesenchymal stem cells.	Formaldehyde	11-23	fibronectin 1	Mus musculus	36-47
27612648-6	2016	Thus, controlled formaldehyde fixation of layers formed by fibronectin or some other extracellular matrix components represents a simple and reproducible way to enhance proliferation of primary cells.	Formaldehyde	17-29	fibronectin 1	Mus musculus	59-70
27845440-8	2016	Formalin tests in orexin neuron-ablated and orexin peptide-deficient mice showed orexinergic transmission was essential for linalool odour-induced analgesia.	Formaldehyde	0-8	hypocretin	Mus musculus	18-24
27498289-2	2016	METHODS: We retrospectively analyzed the expression of beta-catenin and cyclin D1 using immunohistochemistry in formalin-fixed paraffin-embedded tissues from 576 patients with early-stage NSCLC.	Formaldehyde	112-120	catenin beta 1	Homo sapiens	55-67
27616424-9	2016	Inhibition of VEGF receptor-2 signaling in the spinal cord attenuated behavioral nociceptive responses to mechanical, heat and formalin stimuli, indicating that spinal VEGF receptor-2 activation has potent pro-nociceptive actions.	Formaldehyde	127-135	vascular endothelial growth factor A	Homo sapiens	14-18
27616424-9	2016	Inhibition of VEGF receptor-2 signaling in the spinal cord attenuated behavioral nociceptive responses to mechanical, heat and formalin stimuli, indicating that spinal VEGF receptor-2 activation has potent pro-nociceptive actions.	Formaldehyde	127-135	vascular endothelial growth factor A	Homo sapiens	168-172
27573466-11	2016	An array-CGH (comparative genome hybridization) and next-generation sequencing analysis of the tumor DNA extracted from the formalin-fixed paraffin-embedded tissue reveals chromosome 6p gain and p.Q209P mutation in the GNAQ gene, respectively, consistent with the diagnosis of intermediate-grade melanocytoma.	Formaldehyde	124-132	G protein subunit alpha q	Homo sapiens	219-223
27562488-9	2016	In addition to highlighting motile cilia, ARL13B immunohistochemistry also robustly highlights primary cilia in formalin-fixed paraffin-embedded sections.	Formaldehyde	112-120	ADP ribosylation factor like GTPase 13B	Homo sapiens	42-48
27449278-7	2016	OXT (1x10-5-1x10-4nmol) or 5-HT (1x10-3-1x10-1nmol) prevented the formalin-induced sensitization, an effect mimicked by PVN stimulation.	Formaldehyde	66-74	oxytocin/neurophysin I prepropeptide	Rattus norvegicus	0-3
27622578-8	2016	Moreover, formaldehyde stimulation was able to induce ERK pathway activation.	Formaldehyde	10-22	mitogen-activated protein kinase 1	Homo sapiens	54-57
26746842-9	2016	CONCLUSION: The HER2 DISH assay, utilizing 10 % buffered formalin-fixed CB, would be a reliable and ideal method to assess the HER2 gene status of breast cancer cytological specimens.	Formaldehyde	57-65	erb-b2 receptor tyrosine kinase 2	Homo sapiens	16-20
27832134-0	2016	Comparison of the QuantiGene 2.0 Assay and Real-Time RT-PCR in the Detection of p53 Isoform mRNA Expression in Formalin-Fixed Paraffin-Embedded Tissues- A Preliminary Study.	Formaldehyde	111-119	tumor protein p53	Homo sapiens	80-83
27832134-4	2016	However, there are serious limitations when detecting p53 isoforms using this method, particularly for formalin-fixed paraffin-embedded (FFPE) tissues.	Formaldehyde	103-111	tumor protein p53	Homo sapiens	54-57
26746842-9	2016	CONCLUSION: The HER2 DISH assay, utilizing 10 % buffered formalin-fixed CB, would be a reliable and ideal method to assess the HER2 gene status of breast cancer cytological specimens.	Formaldehyde	57-65	erb-b2 receptor tyrosine kinase 2	Homo sapiens	127-131
27589204-1	2016	Germline PMS2 gene mutations were detected by RT-PCR/direct sequencing of total RNA extracted from puromycin-treated peripheral blood lymphocytes (PBL) and multiplex ligation-dependent probe amplification (MLPA) analyses of Japanese patients with colorectal cancer (CRC) fulfilling either the revised Bethesda Guidelines or being an age at disease onset of younger than 70 years, and screened by mismatch repair protein immunohistochemistry of formalin-fixed paraffin embedded sections.	Formaldehyde	444-452	PMS1 homolog 2, mismatch repair system component	Homo sapiens	9-13
27315045-10	2016	CONCLUSIONS: ER, PR, and HER2 determination on FNA-acquired cell block (fixed exclusively in 10% formalin) showed excellent agreement for ER and HER2 and moderate agreement for PR with the corresponding tissue block.	Formaldehyde	97-105	estrogen receptor 1	Homo sapiens	13-15
27315045-10	2016	CONCLUSIONS: ER, PR, and HER2 determination on FNA-acquired cell block (fixed exclusively in 10% formalin) showed excellent agreement for ER and HER2 and moderate agreement for PR with the corresponding tissue block.	Formaldehyde	97-105	erb-b2 receptor tyrosine kinase 2	Homo sapiens	25-29
27315045-10	2016	CONCLUSIONS: ER, PR, and HER2 determination on FNA-acquired cell block (fixed exclusively in 10% formalin) showed excellent agreement for ER and HER2 and moderate agreement for PR with the corresponding tissue block.	Formaldehyde	97-105	estrogen receptor 1	Homo sapiens	26-28
27315045-10	2016	CONCLUSIONS: ER, PR, and HER2 determination on FNA-acquired cell block (fixed exclusively in 10% formalin) showed excellent agreement for ER and HER2 and moderate agreement for PR with the corresponding tissue block.	Formaldehyde	97-105	erb-b2 receptor tyrosine kinase 2	Homo sapiens	145-149
27264026-0	2016	Amylin modulates the formalin-induced tonic pain behaviours in rats.	Formaldehyde	21-29	islet amyloid polypeptide	Rattus norvegicus	0-6
27101548-2	2016	Our aim was to evaluate how different characteristics from formalin-fixed paraffin-embedded (FFPE) samples, age of the block or DNA concentration could influence the success of BRAF and NRAS mutational screening.	Formaldehyde	59-67	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	177-181
27796833-9	2016	Induction of AChE activity was observed in formaldehyde-exposed workers as compared with the control group (p &lt; 0.01), while AChE activity increased in 64 % of the exposed subjects.	Formaldehyde	43-55	acetylcholinesterase (Cartwright blood group)	Homo sapiens	13-17
27796833-10	2016	Spearman"s correlation (p &lt; 0.02) was used to evaluate the association between AChE activity and occupational exposure to formaldehyde.	Formaldehyde	125-137	acetylcholinesterase (Cartwright blood group)	Homo sapiens	82-86
27796833-12	2016	The findings of this study suggest that the neurotoxic effect of formaldehyde depends on the AChE activity, which is affected by metabolism.	Formaldehyde	65-77	acetylcholinesterase (Cartwright blood group)	Homo sapiens	93-97
27781423-6	2016	Interphase fluorescent in situ hybridization (FISH) study on touch preparations from frozen tumor and formaldehyde-fixed, paraffin-embedded histological sections showed amplification of MYC in both PNET-like and gliomatous areas.	Formaldehyde	102-114	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	186-189
27264026-3	2016	METHODS: The effect of amylin"s administration on the formalin test of acute and tonic pain was evaluated.	Formaldehyde	54-62	islet amyloid polypeptide	Rattus norvegicus	23-29
27264026-10	2016	CONCLUSIONS: Overall, data suggested that amylin modulates pain with an inflammatory component and the autoanalgesic/inhibitory mechanisms occurring in the interphase of the formalin test.	Formaldehyde	174-182	islet amyloid polypeptide	Rattus norvegicus	42-48
27264026-13	2016	: Amylin modulated formalin interphase and tonic pain behaviours probably by targeting spinal neurons and affecting supraspinal areas involved in affective and modulatory components of pain.	Formaldehyde	19-27	islet amyloid polypeptide	Rattus norvegicus	2-8
27654256-2	2016	METHODS: Immunohistochemistry was performed to detect the expression of CK19 and SCCAg using polyclonal antibody on 149 pair of formalin-fixed, paraffin-embedded cervical squamous cell carcinoma and histologically negative sentinel lymph node tissue samples, and results were compared with data from the prospectively registry of cervical squamous cell carcinoma by univariate and multivariate logistic regression model focusing specifically on recurrence.	Formaldehyde	128-136	keratin 19	Homo sapiens	72-76
27520401-4	2016	In the present study, we investigated the role of TRPV1 in the sub-columns of the PAG in formalin-evoked nociceptive behaviour in WKY versus Sprague-Dawley (SD) rats.	Formaldehyde	89-97	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	50-55
27760890-6	2016	Molecular studies with formalin-fixed, paraffin-embedded tissues were performed in search of a partial region of the cytochrome b gene for hemosporidian parasites.	Formaldehyde	23-31	CYTB	Gallus gallus	117-129
27482631-4	2016	This increase was maximal 30 minutes after formalin injection and occurred mainly within p-ERK-positive neurons.	Formaldehyde	43-51	mitogen-activated protein kinase 1	Homo sapiens	91-94
27482631-7	2016	We found that, after formalin injection, most phospho-MSK1 (p-MSK1)-positive cells (87% +- 3%) expressed p-ERK and the majority of p-H3S10-positive cells (85% +- 5%) expressed p-MSK1.	Formaldehyde	21-29	ribosomal protein S6 kinase A5	Homo sapiens	54-58
27482631-7	2016	We found that, after formalin injection, most phospho-MSK1 (p-MSK1)-positive cells (87% +- 3%) expressed p-ERK and the majority of p-H3S10-positive cells (85% +- 5%) expressed p-MSK1.	Formaldehyde	21-29	ribosomal protein S6 kinase A5	Homo sapiens	62-66
27482631-7	2016	We found that, after formalin injection, most phospho-MSK1 (p-MSK1)-positive cells (87% +- 3%) expressed p-ERK and the majority of p-H3S10-positive cells (85% +- 5%) expressed p-MSK1.	Formaldehyde	21-29	ribosomal protein S6 kinase A5	Homo sapiens	62-66
27482631-8	2016	Inhibition of ERK activity with the MEK inhibitor SL327 reduced formalin-induced p-ERK, p-MSK1, and p-H3S10, demonstrating that spinal p-MSK1 and p-H3S10 were at least partly downstream of ERK signalling.	Formaldehyde	64-72	mitogen-activated protein kinase 1	Homo sapiens	14-17
27482631-8	2016	Inhibition of ERK activity with the MEK inhibitor SL327 reduced formalin-induced p-ERK, p-MSK1, and p-H3S10, demonstrating that spinal p-MSK1 and p-H3S10 were at least partly downstream of ERK signalling.	Formaldehyde	64-72	mitogen-activated protein kinase kinase 7	Homo sapiens	36-39
27482631-8	2016	Inhibition of ERK activity with the MEK inhibitor SL327 reduced formalin-induced p-ERK, p-MSK1, and p-H3S10, demonstrating that spinal p-MSK1 and p-H3S10 were at least partly downstream of ERK signalling.	Formaldehyde	64-72	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	81-86
27482631-8	2016	Inhibition of ERK activity with the MEK inhibitor SL327 reduced formalin-induced p-ERK, p-MSK1, and p-H3S10, demonstrating that spinal p-MSK1 and p-H3S10 were at least partly downstream of ERK signalling.	Formaldehyde	64-72	ribosomal protein S6 kinase A5	Homo sapiens	90-94
27482631-8	2016	Inhibition of ERK activity with the MEK inhibitor SL327 reduced formalin-induced p-ERK, p-MSK1, and p-H3S10, demonstrating that spinal p-MSK1 and p-H3S10 were at least partly downstream of ERK signalling.	Formaldehyde	64-72	ribosomal protein S6 kinase A5	Homo sapiens	137-141
27482631-8	2016	Inhibition of ERK activity with the MEK inhibitor SL327 reduced formalin-induced p-ERK, p-MSK1, and p-H3S10, demonstrating that spinal p-MSK1 and p-H3S10 were at least partly downstream of ERK signalling.	Formaldehyde	64-72	mitogen-activated protein kinase 1	Homo sapiens	83-86
27482631-9	2016	Crucially, pharmacological blockade of spinal MSK1 activity with the novel MSK1 inhibitor SB727651A inhibited formalin-induced spinal p-H3S10 and nocifensive behaviour.	Formaldehyde	110-118	ribosomal protein S6 kinase A5	Homo sapiens	46-50
27482631-9	2016	Crucially, pharmacological blockade of spinal MSK1 activity with the novel MSK1 inhibitor SB727651A inhibited formalin-induced spinal p-H3S10 and nocifensive behaviour.	Formaldehyde	110-118	ribosomal protein S6 kinase A5	Homo sapiens	75-79
27520401-7	2016	TRPV1 mRNA expression significantly decreased in the DLPAG and increased in the VLPAG of SD, but not WKY rats upon intra-plantar formalin administration.	Formaldehyde	129-137	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	0-5
27520401-8	2016	Intra-DLPAG administration of either the TRPV1 agonist capsaicin, or the TRPV1 antagonist 5"-Iodoresiniferatoxin (5"-IRTX), significantly increased formalin-evoked nociceptive behaviour in SD rats, but not in WKY rats.	Formaldehyde	148-156	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	41-46
27520401-8	2016	Intra-DLPAG administration of either the TRPV1 agonist capsaicin, or the TRPV1 antagonist 5"-Iodoresiniferatoxin (5"-IRTX), significantly increased formalin-evoked nociceptive behaviour in SD rats, but not in WKY rats.	Formaldehyde	148-156	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	73-78
26229097-0	2016	Formaldehyde exposure inhibits the expression of mammalian target of rapamycin in rat testis.	Formaldehyde	0-12	mechanistic target of rapamycin kinase	Homo sapiens	49-78
27520589-11	2016	Restraint stress prevented formalin-induced increases in extracellular signal regulated kinase 2 (ERK2) phosphorylation in the male CeA, but no changes associated with pERK2 were seen with formalin or restraint in females.	Formaldehyde	27-35	mitogen-activated protein kinase 1	Mus musculus	57-96
27664576-7	2016	Interestingly, the sub-cytotoxic formaldehyde affected NHKs to upregulate two enzymes important in the cellular transsulfuration pathway, cystathionine gamma-lyase (CTH) and cystathionine-beta-synthase (CBS).	Formaldehyde	33-45	cystathionine gamma-lyase	Homo sapiens	138-163
27664576-7	2016	Interestingly, the sub-cytotoxic formaldehyde affected NHKs to upregulate two enzymes important in the cellular transsulfuration pathway, cystathionine gamma-lyase (CTH) and cystathionine-beta-synthase (CBS).	Formaldehyde	33-45	cystathionine gamma-lyase	Homo sapiens	165-168
27664576-7	2016	Interestingly, the sub-cytotoxic formaldehyde affected NHKs to upregulate two enzymes important in the cellular transsulfuration pathway, cystathionine gamma-lyase (CTH) and cystathionine-beta-synthase (CBS).	Formaldehyde	33-45	cystathionine beta-synthase	Homo sapiens	174-201
27664576-7	2016	Interestingly, the sub-cytotoxic formaldehyde affected NHKs to upregulate two enzymes important in the cellular transsulfuration pathway, cystathionine gamma-lyase (CTH) and cystathionine-beta-synthase (CBS).	Formaldehyde	33-45	cystathionine beta-synthase	Homo sapiens	203-206
27664576-9	2016	The metabolites of CTH and CBS, l-cystathionine and l-cysteine, attenuated the formaldehyde-induced upregulation of pro-inflammatory DEGs, MMP1, PTGS2, and CXCL8, suggesting that CTH and CBS play a role in the negative feedback regulation of formaldehyde-induced pro-inflammatory responses in NHKs.	Formaldehyde	79-91	cystathionine gamma-lyase	Homo sapiens	19-22
27664576-9	2016	The metabolites of CTH and CBS, l-cystathionine and l-cysteine, attenuated the formaldehyde-induced upregulation of pro-inflammatory DEGs, MMP1, PTGS2, and CXCL8, suggesting that CTH and CBS play a role in the negative feedback regulation of formaldehyde-induced pro-inflammatory responses in NHKs.	Formaldehyde	79-91	cystathionine beta-synthase	Homo sapiens	27-30
27664576-9	2016	The metabolites of CTH and CBS, l-cystathionine and l-cysteine, attenuated the formaldehyde-induced upregulation of pro-inflammatory DEGs, MMP1, PTGS2, and CXCL8, suggesting that CTH and CBS play a role in the negative feedback regulation of formaldehyde-induced pro-inflammatory responses in NHKs.	Formaldehyde	79-91	matrix metallopeptidase 1	Homo sapiens	139-143
27664576-9	2016	The metabolites of CTH and CBS, l-cystathionine and l-cysteine, attenuated the formaldehyde-induced upregulation of pro-inflammatory DEGs, MMP1, PTGS2, and CXCL8, suggesting that CTH and CBS play a role in the negative feedback regulation of formaldehyde-induced pro-inflammatory responses in NHKs.	Formaldehyde	79-91	prostaglandin-endoperoxide synthase 2	Homo sapiens	145-150
27664576-9	2016	The metabolites of CTH and CBS, l-cystathionine and l-cysteine, attenuated the formaldehyde-induced upregulation of pro-inflammatory DEGs, MMP1, PTGS2, and CXCL8, suggesting that CTH and CBS play a role in the negative feedback regulation of formaldehyde-induced pro-inflammatory responses in NHKs.	Formaldehyde	79-91	C-X-C motif chemokine ligand 8	Homo sapiens	156-161
27664576-9	2016	The metabolites of CTH and CBS, l-cystathionine and l-cysteine, attenuated the formaldehyde-induced upregulation of pro-inflammatory DEGs, MMP1, PTGS2, and CXCL8, suggesting that CTH and CBS play a role in the negative feedback regulation of formaldehyde-induced pro-inflammatory responses in NHKs.	Formaldehyde	79-91	cystathionine gamma-lyase	Homo sapiens	179-182
27664576-9	2016	The metabolites of CTH and CBS, l-cystathionine and l-cysteine, attenuated the formaldehyde-induced upregulation of pro-inflammatory DEGs, MMP1, PTGS2, and CXCL8, suggesting that CTH and CBS play a role in the negative feedback regulation of formaldehyde-induced pro-inflammatory responses in NHKs.	Formaldehyde	79-91	cystathionine beta-synthase	Homo sapiens	187-190
27664576-9	2016	The metabolites of CTH and CBS, l-cystathionine and l-cysteine, attenuated the formaldehyde-induced upregulation of pro-inflammatory DEGs, MMP1, PTGS2, and CXCL8, suggesting that CTH and CBS play a role in the negative feedback regulation of formaldehyde-induced pro-inflammatory responses in NHKs.	Formaldehyde	242-254	cystathionine gamma-lyase	Homo sapiens	19-22
27664576-9	2016	The metabolites of CTH and CBS, l-cystathionine and l-cysteine, attenuated the formaldehyde-induced upregulation of pro-inflammatory DEGs, MMP1, PTGS2, and CXCL8, suggesting that CTH and CBS play a role in the negative feedback regulation of formaldehyde-induced pro-inflammatory responses in NHKs.	Formaldehyde	242-254	cystathionine beta-synthase	Homo sapiens	27-30
27664576-10	2016	In this regard, the sub-cytotoxic formaldehyde-induced CBS and CTH may regulate inflammation fate decision to resolution by suppressing the early pro-inflammatory response.	Formaldehyde	34-46	cystathionine beta-synthase	Homo sapiens	55-58
27664576-10	2016	In this regard, the sub-cytotoxic formaldehyde-induced CBS and CTH may regulate inflammation fate decision to resolution by suppressing the early pro-inflammatory response.	Formaldehyde	34-46	cystathionine gamma-lyase	Homo sapiens	63-66
27818595-3	2016	Expression of COX-2 and EP1 receptor was examined by immunohistochemistry of formalin-fixed, paraffin-embedded tissues using polyclonal antibodies.	Formaldehyde	77-85	prostaglandin-endoperoxide synthase 2	Homo sapiens	14-19
27818595-3	2016	Expression of COX-2 and EP1 receptor was examined by immunohistochemistry of formalin-fixed, paraffin-embedded tissues using polyclonal antibodies.	Formaldehyde	77-85	prostaglandin E receptor 1	Homo sapiens	24-27
27520589-11	2016	Restraint stress prevented formalin-induced increases in extracellular signal regulated kinase 2 (ERK2) phosphorylation in the male CeA, but no changes associated with pERK2 were seen with formalin or restraint in females.	Formaldehyde	27-35	mitogen-activated protein kinase 1	Mus musculus	98-102
27520589-11	2016	Restraint stress prevented formalin-induced increases in extracellular signal regulated kinase 2 (ERK2) phosphorylation in the male CeA, but no changes associated with pERK2 were seen with formalin or restraint in females.	Formaldehyde	27-35	carcinoembryonic antigen gene family	Mus musculus	132-135
27717372-2	2016	Here we describe a PD-L1 immunohistochemical (IHC) staining protocol developed by Ventana Medical Systems Inc. and key analytical parameters of its use in formalin-fixed, paraffin-embedded (FFPE) samples of non-small cell lung cancer (NSCLC) and head and neck squamous cell carcinoma (HNSCC).	Formaldehyde	155-163	CD274 molecule	Homo sapiens	19-24
27149505-4	2016	HASM cells were exposed to formaldehyde or vehicle and agonist-induced intracellular Ca2+ ([Ca2+]i) and myosin light-chain phosphatase (MYPT1) phosphorylation were determined.	Formaldehyde	27-39	protein phosphatase 1 regulatory subunit 12A	Homo sapiens	136-141
27552660-0	2016	Potential Energy Surfaces for the Reactions of HO2 Radical with CH2O and HO2 in CO2 Environment.	Formaldehyde	64-68	heme oxygenase 2	Homo sapiens	47-50
27552660-1	2016	We report on potential energies for the transition state, reactant, and product complexes along the reaction pathways for hydrogen transfer reactions to hydroperoxyl radical from formaldehyde H2CO + HO2   HCO + H2O2 and another hydroperoxyl radical 2HO2   H2O2 + O2 in the presence of one carbon dioxide molecule.	Formaldehyde	179-191	heme oxygenase 2	Homo sapiens	199-202
27552660-1	2016	We report on potential energies for the transition state, reactant, and product complexes along the reaction pathways for hydrogen transfer reactions to hydroperoxyl radical from formaldehyde H2CO + HO2   HCO + H2O2 and another hydroperoxyl radical 2HO2   H2O2 + O2 in the presence of one carbon dioxide molecule.	Formaldehyde	192-196	heme oxygenase 2	Homo sapiens	199-202
27699080-6	2016	An intravenous injection of AVP into the tail induced decreases in the drinking frequency and water intake in the mice, and these decreases were associated with increases in brain formaldehyde levels.	Formaldehyde	180-192	arginine vasopressin	Mus musculus	28-31
27699080-7	2016	An ELISA assay revealed that the AVP injection increased both the protein level and the enzymatic activity of semicarbazide-sensitive amine oxidase (SSAO), which is an enzyme that produces formaldehyde.	Formaldehyde	189-201	arginine vasopressin	Mus musculus	33-36
27699080-7	2016	An ELISA assay revealed that the AVP injection increased both the protein level and the enzymatic activity of semicarbazide-sensitive amine oxidase (SSAO), which is an enzyme that produces formaldehyde.	Formaldehyde	189-201	amine oxidase, copper containing 3	Mus musculus	110-147
27699080-7	2016	An ELISA assay revealed that the AVP injection increased both the protein level and the enzymatic activity of semicarbazide-sensitive amine oxidase (SSAO), which is an enzyme that produces formaldehyde.	Formaldehyde	189-201	amine oxidase, copper containing 3	Mus musculus	149-153
27699080-8	2016	In contrast, the intraperitoneal injection of formaldehyde increased the serum AVP level by increasing the angiotensin II (ANG II) level, and this change was associated with a marked decrease in water intake behavior.	Formaldehyde	46-58	arginine vasopressin	Mus musculus	79-82
27699080-8	2016	In contrast, the intraperitoneal injection of formaldehyde increased the serum AVP level by increasing the angiotensin II (ANG II) level, and this change was associated with a marked decrease in water intake behavior.	Formaldehyde	46-58	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	107-121
27699080-8	2016	In contrast, the intraperitoneal injection of formaldehyde increased the serum AVP level by increasing the angiotensin II (ANG II) level, and this change was associated with a marked decrease in water intake behavior.	Formaldehyde	46-58	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	123-129
27699080-9	2016	These data suggest that the interaction between formaldehyde and AVP affects the water intake behaviors of mice.	Formaldehyde	48-60	arginine vasopressin	Mus musculus	65-68
27686768-10	2016	The median formaldehyde and benzene concentrations in cases(32.120 pg/ml, 2.505 mug/gCr)were significantly higher than those in controls(18.705 pg/ml, 0.672 mug/gCr; Z values:-1.98 and-3.95, P values: 0.047 and&lt;0.001, respectively).	Formaldehyde	11-23	nuclear receptor subfamily 3 group C member 1	Homo sapiens	84-87
27149505-9	2016	Formaldehyde enhanced the basal Rho-kinase activity and MYPT1 phosphorylation with little effect on agonist-induced [Ca2+]i in HASM cells.	Formaldehyde	0-12	protein phosphatase 1 regulatory subunit 12A	Homo sapiens	56-61
27149505-10	2016	Formaldehyde induced Nrf-2-dependent antioxidant response in HASM cells, although the MYPT1 phosphorylation was independent of Nrf-2 induction.	Formaldehyde	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	21-26
27149505-12	2016	In conclusion, formaldehyde induces phosphorylation of the regulatory subunit of MYPT1, independent of formaldehyde-induced Nrf-2 activation in HASM cells.	Formaldehyde	15-27	protein phosphatase 1 regulatory subunit 12A	Homo sapiens	81-86
27529639-9	2016	The kinetics of the HO2 + CH2NH reaction system differs substantially from the analogous isoelectronic reaction systems involving C2H4 and CH2O, which have been the subjects of previous experimental and theoretical studies.	Formaldehyde	139-143	heme oxygenase 2	Homo sapiens	20-23
28243282-0	2016	Intra-accumbal Orexin-1 Receptors are Involved in Antinociception Induced by Stimulation of the Lateral Hypothalamus in the Formalin Test as an Animal Model of Persistent Inflammatory Pain.	Formaldehyde	124-132	hypocretin neuropeptide precursor	Rattus norvegicus	15-21
27456361-3	2016	First of all, the expression of BAG3 was examined in formalin-fixed, paraffin-embedded specimens by immunohistochemical staining.	Formaldehyde	53-61	BAG cochaperone 3	Homo sapiens	32-36
27542245-2	2016	METHODS: The MGMT status of 139 glioblastoma patients, whom had received standard first line treatment, was determined using pyrosequencing (PSQ) and a semi-quantitative Methylation-specific PCR (sqMS-PCR) method, using both frozen and formalin-fixed paraffin-embedded FFPE samples.	Formaldehyde	236-244	O-6-methylguanine-DNA methyltransferase	Homo sapiens	13-17
27166394-4	2016	Copy number alterations of the PD-L1 gene in 11 cases were assessed in formalin-fixed, paraffin-embedded material using qRT-PCR.	Formaldehyde	71-79	CD274 molecule	Homo sapiens	31-36
26574629-0	2016	GNAS Mutations in Fibrous Dysplasia: A Comparative Study of Standard Sequencing and Locked Nucleic Acid PCR Sequencing on Decalcified and Nondecalcified Formalin-fixed Paraffin-embedded Tissues.	Formaldehyde	153-161	GNAS complex locus	Homo sapiens	0-4
27391144-3	2016	Expression of COX-2 was detected immunohistochemically in standard sections of formalin-fixed paraffin-embedded tissue samples of 85 primary melanomas, 36 lymph node metastases, and five skin metastases including 39 cases of paired primary and metastatic lesions obtained from the same patient.	Formaldehyde	79-87	prostaglandin-endoperoxide synthase 2	Homo sapiens	14-19
27705080-7	2016	Moreover, the anti-Pax1 MAbs cross-react with human PAX1 protein and are applicable in immunohistochemical detection procedures using paraformaldehyde/formalin-fixed tissues embedded in paraffin.	Formaldehyde	151-159	paired box 1	Homo sapiens	19-23
27705080-7	2016	Moreover, the anti-Pax1 MAbs cross-react with human PAX1 protein and are applicable in immunohistochemical detection procedures using paraformaldehyde/formalin-fixed tissues embedded in paraffin.	Formaldehyde	151-159	paired box 1	Homo sapiens	52-56
27685259-0	2016	Multi-Center Evaluation of the Fully Automated PCR-Based Idylla  KRAS Mutation Assay for Rapid KRAS Mutation Status Determination on Formalin-Fixed Paraffin-Embedded Tissue of Human Colorectal Cancer.	Formaldehyde	133-141	KRAS proto-oncogene, GTPase	Homo sapiens	65-69
27685259-0	2016	Multi-Center Evaluation of the Fully Automated PCR-Based Idylla  KRAS Mutation Assay for Rapid KRAS Mutation Status Determination on Formalin-Fixed Paraffin-Embedded Tissue of Human Colorectal Cancer.	Formaldehyde	133-141	KRAS proto-oncogene, GTPase	Homo sapiens	95-99
27533253-2	2016	This raises the need for new diagnostic methods that are capable of performing an integrative mutation analysis of the BRCA genes not only from germline DNA but also from formalin-fixed and paraffin-embedded (FFPE) tumor samples.	Formaldehyde	171-179	BRCA1 DNA repair associated	Homo sapiens	119-123
27672647-3	2016	In this case report, human telomerase reverse transcriptase (hTERT) and high mobility group-A1 (HMGA1); markers of proliferation and stemness, have been quantitatively analyzed in formalin-fixed paraffin-embedded tissue samples of a 34 years old patient with oligoastrocytoma.	Formaldehyde	180-188	high mobility group AT-hook 1	Homo sapiens	96-101
27174194-1	2016	AIMS: To detect MYB gene breaks in adenoid cystic carcinoma (ACC) of the salivary glands and its correlation with prognosis and selected clinical parameters METHODS: MYB gene break was detected by FISH assay in 23 adenoid cystic carcinomas using formalin-fixed paraffin-embedded blocks.	Formaldehyde	246-254	MYB proto-oncogene, transcription factor	Homo sapiens	16-19
27598247-9	2016	As an alternative method to detect claudin-2 expression and distribution in formalin fixed biopsy sections, an in situ hybridization assay was developed.	Formaldehyde	76-84	claudin 2	Homo sapiens	35-44
27163752-5	2016	Intraplantar injection of 5% formalin was associated with significant activation of mTOR, as well as p70 ribosomal S6 protein (p70S6K), its downstream effector, in the rACC.	Formaldehyde	29-37	mechanistic target of rapamycin kinase	Homo sapiens	84-88
27163752-5	2016	Intraplantar injection of 5% formalin was associated with significant activation of mTOR, as well as p70 ribosomal S6 protein (p70S6K), its downstream effector, in the rACC.	Formaldehyde	29-37	ribosomal protein S6 kinase B1	Homo sapiens	127-133
27632281-5	2016	KRAS multiplex mutation analysis usefulness was also demonstrated with formalin-fixed paraffin embedded (FFPE) from CRC biopsies.	Formaldehyde	71-79	KRAS proto-oncogene, GTPase	Homo sapiens	0-4
27490749-4	2016	We completed a preliminary clinical trial applying cantilever array sensors to demonstrate identification of a BRAF(V600E) single-point mutation using total RNA obtained from biopsies of metastatic melanoma of diverse sources (surgical material either frozen or fixated with formalin and embedded in paraffin).	Formaldehyde	275-283	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	111-116
27509322-1	2016	The reaction rates of (CH3)2NNO and (CH3CH2)2NNO with NO3 radicals were determined relative to formaldehyde (CH2O) and ethene (CH2CH2) at 298 +- 2 K and 1013 +- 10 hPa in purified air by long path FTIR spectroscopy.	Formaldehyde	109-113	NBL1, DAN family BMP antagonist	Homo sapiens	54-57
27491898-4	2016	Formalin-fixed, paraffin-embedded pretreatment tumor biopsies expressing PD-L1 were derived from 13 RCC patients.	Formaldehyde	0-8	CD274 molecule	Homo sapiens	73-78
27174194-1	2016	AIMS: To detect MYB gene breaks in adenoid cystic carcinoma (ACC) of the salivary glands and its correlation with prognosis and selected clinical parameters METHODS: MYB gene break was detected by FISH assay in 23 adenoid cystic carcinomas using formalin-fixed paraffin-embedded blocks.	Formaldehyde	246-254	MYB proto-oncogene, transcription factor	Homo sapiens	166-169
26931482-5	2016	Deficiency in Pdk2 and/or Pdk4 in mice led to attenuation of formalin-induced nociceptive behaviors (flinching, licking, biting, or lifting of the injected paw).	Formaldehyde	61-69	pyruvate dehydrogenase kinase, isoenzyme 2	Mus musculus	14-18
26296380-3	2016	BRAF exon 15 mutations were searched in formalin-fixed paraffin-embedded tissues from 86 papillary thyroid carcinoma using the three methods.	Formaldehyde	40-48	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	0-4
26931482-8	2016	Formalin-driven neutrophil recruitment at the site of inflammation, spinal glial activation, and neuronal sensitization were substantially lessened in the second or late phase of the formalin test in Pdk2/4-deficient animals.	Formaldehyde	183-191	pyruvate dehydrogenase kinase, isoenzyme 2	Mus musculus	200-204
27287872-5	2016	Furthermore, in our large set of formalin-fixed paraffin-embedded cohort (n = 338), VCAN protein was detected exclusively in cancer stroma by immunohistochemistry, demonstrating a stepwise increase of stromal VCAN from normal tissues through stage 0 to stage IV tumors.	Formaldehyde	33-41	versican	Homo sapiens	84-88
27287872-5	2016	Furthermore, in our large set of formalin-fixed paraffin-embedded cohort (n = 338), VCAN protein was detected exclusively in cancer stroma by immunohistochemistry, demonstrating a stepwise increase of stromal VCAN from normal tissues through stage 0 to stage IV tumors.	Formaldehyde	33-41	versican	Homo sapiens	209-213
27514839-1	2016	Increased demand for BRCA testing is placing pressures on diagnostic laboratories to raise their mutation screening capacity and handle the challenges associated with classifying BRCA sequence variants for clinical significance, for example interpretation of pathogenic mutations or variants of unknown significance, accurate determination of large genomic rearrangements and detection of somatic mutations in DNA extracted from formalin-fixed, paraffin-embedded tumour samples.	Formaldehyde	429-437	BRCA1 DNA repair associated	Homo sapiens	21-25
26931482-5	2016	Deficiency in Pdk2 and/or Pdk4 in mice led to attenuation of formalin-induced nociceptive behaviors (flinching, licking, biting, or lifting of the injected paw).	Formaldehyde	61-69	pyruvate dehydrogenase kinase, isoenzyme 4	Mus musculus	26-30
26931482-6	2016	Likewise, the pharmacological inhibition of PDKs substantially diminished the nociceptive responses in the second phase of the formalin test.	Formaldehyde	127-135	pyruvate dehydrogenase kinase, isoenzyme 1	Mus musculus	44-48
26931482-7	2016	Furthermore, formalin-provoked paw edema formation and mechanical and thermal hypersensitivities were significantly reduced in Pdk2/4-deficient mice.	Formaldehyde	13-21	pyruvate dehydrogenase kinase, isoenzyme 2	Mus musculus	127-131
26931482-8	2016	Formalin-driven neutrophil recruitment at the site of inflammation, spinal glial activation, and neuronal sensitization were substantially lessened in the second or late phase of the formalin test in Pdk2/4-deficient animals.	Formaldehyde	0-8	pyruvate dehydrogenase kinase, isoenzyme 2	Mus musculus	200-204
27411717-2	2016	One of the lines from this screen, which contained a null allele of the adapter protein-2 associated kinase 1 (AAK1) gene, had a normal response in acute pain assays (hot plate, phase I formalin), but a markedly reduced response to persistent pain in phase II formalin.	Formaldehyde	186-194	AP2 associated kinase 1	Rattus norvegicus	111-115
27411717-2	2016	One of the lines from this screen, which contained a null allele of the adapter protein-2 associated kinase 1 (AAK1) gene, had a normal response in acute pain assays (hot plate, phase I formalin), but a markedly reduced response to persistent pain in phase II formalin.	Formaldehyde	260-268	AP2 associated kinase 1	Rattus norvegicus	111-115
27431784-5	2016	The expression levels of miR-203a were analyzed in 109 formalin-fixed paraffin-embedded paired normal and tumor tissue samples.	Formaldehyde	55-63	microRNA 203a	Homo sapiens	25-33
27559738-3	2016	Formalin-fixed paraffin-embedded tissue samples of esophageal biopsy specimens from 73 patients with Barrett"s esophagus with either low-grade dysplasia (LGD) (n = 32) or high-grade dysplasia (HGD) (n = 59) were analyzed for HER1, HER2, HER3 and CMET expression by immunohistochemistry (IHC).	Formaldehyde	0-8	epidermal growth factor receptor	Homo sapiens	225-229
29619286-7	2016	In addition, we find that AM3B shows better agreement on both formaldehyde and the correlation between glyoxal and formaldehyde (RGF = [GLYX]/[HCHO]), resulting from the suppression of delta-isoprene peroxy radicals (delta-ISOPO2).	Formaldehyde	115-127	ral guanine nucleotide dissociation stimulator	Homo sapiens	129-132
27559738-3	2016	Formalin-fixed paraffin-embedded tissue samples of esophageal biopsy specimens from 73 patients with Barrett"s esophagus with either low-grade dysplasia (LGD) (n = 32) or high-grade dysplasia (HGD) (n = 59) were analyzed for HER1, HER2, HER3 and CMET expression by immunohistochemistry (IHC).	Formaldehyde	0-8	erb-b2 receptor tyrosine kinase 2	Homo sapiens	231-235
27559738-3	2016	Formalin-fixed paraffin-embedded tissue samples of esophageal biopsy specimens from 73 patients with Barrett"s esophagus with either low-grade dysplasia (LGD) (n = 32) or high-grade dysplasia (HGD) (n = 59) were analyzed for HER1, HER2, HER3 and CMET expression by immunohistochemistry (IHC).	Formaldehyde	0-8	erb-b2 receptor tyrosine kinase 3	Homo sapiens	237-241
27559738-3	2016	Formalin-fixed paraffin-embedded tissue samples of esophageal biopsy specimens from 73 patients with Barrett"s esophagus with either low-grade dysplasia (LGD) (n = 32) or high-grade dysplasia (HGD) (n = 59) were analyzed for HER1, HER2, HER3 and CMET expression by immunohistochemistry (IHC).	Formaldehyde	0-8	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	246-250
27504971-3	2016	METHODS: We examined the expression of miR-4443 in MDA-MB-231/S and MDA-MB-231 Epirubicin-resistant cell lines with 76 breast cancer formalin-fixed paraffin-embedded tissues by real-time PCR.	Formaldehyde	133-141	microRNA 4443	Homo sapiens	39-47
27579449-5	2016	The presence of IgA1 was confirmed in formalin-fixed paraffin-embedded ovarian carcinoma samples using LC-MS/MS analysis.	Formaldehyde	38-46	immunoglobulin heavy constant alpha 1	Homo sapiens	16-20
27259009-4	2016	beta-catenin immunohistochemistry was performed on formalin-fixed, paraffin-embedded whole sections from 73 tumors.	Formaldehyde	51-59	catenin beta 1	Homo sapiens	0-12
27618787-3	2016	The purpose of this study was to accurately quantify HER2-HER3 dimerisation in formalin fixed paraffin embedded (FFPE) breast cancer tissue as a novel prognostic biomarker.FFPE tissues were obtained from patients included in the METABRIC (Molecular Taxonomy of Breast Cancer International Consortium) study.	Formaldehyde	79-87	erb-b2 receptor tyrosine kinase 2	Homo sapiens	53-57
27618787-3	2016	The purpose of this study was to accurately quantify HER2-HER3 dimerisation in formalin fixed paraffin embedded (FFPE) breast cancer tissue as a novel prognostic biomarker.FFPE tissues were obtained from patients included in the METABRIC (Molecular Taxonomy of Breast Cancer International Consortium) study.	Formaldehyde	79-87	erb-b2 receptor tyrosine kinase 3	Homo sapiens	58-62
27373711-1	2016	On-tissue digestion matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) can be used to record spatially correlated molecular information from formalin-fixed, paraffin-embedded (FFPE) tissue sections.	Formaldehyde	172-180	RB binding protein 4, chromatin remodeling factor	Homo sapiens	97-100
27243753-3	2016	EXPERIMENTAL APPROACH: Initial studies examined the alpha7 ago-PAM, GAT107, in the formalin, complete Freund"s adjuvant (CFA), LPS inflammatory pain models, the chronic constriction injury neuropathic pain model and the tail flick and hot plate acute thermal nociceptive assays.	Formaldehyde	83-91	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	52-66
26871404-3	2016	In this study, the role of intra-accumbal orexin-2 receptors (OX2rs) in the mediation of formalin-induced pain was investigated.	Formaldehyde	89-97	hypocretin neuropeptide precursor	Homo sapiens	42-48
26871404-7	2016	The findings showed that TCS OX2 29 administration dose dependently blocked carbachol-induced antinociception during both phases of formalin-induced pain.	Formaldehyde	132-140	CD200 molecule	Homo sapiens	29-32
26965218-7	2016	Administration of capsaicin (a TRPV1 agonist) into the RVM decreased nociceptive behavioural responses in the inflammatory phase of the formalin test (phase 2).	Formaldehyde	136-144	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	31-36
27045402-1	2016	In the present study, our aim was to assess the incidence of BCL-1 gene rearrangements in formalin-fixed paraffin embedded (FFPE) tissue in patients with non-Hodgkin lymphomas (NHL).	Formaldehyde	90-98	cyclin D1	Homo sapiens	61-66
27567476-5	2016	These findings suggest that CS attenuates formalin-induced tactile allodynia through the inhibition of p38 MAPK phosphorylation and subsequent up-regulation of c-Fos expression in the dorsal lumbar spinal cord.	Formaldehyde	42-50	mitogen-activated protein kinase 14	Mus musculus	103-106
27567476-5	2016	These findings suggest that CS attenuates formalin-induced tactile allodynia through the inhibition of p38 MAPK phosphorylation and subsequent up-regulation of c-Fos expression in the dorsal lumbar spinal cord.	Formaldehyde	42-50	FBJ osteosarcoma oncogene	Mus musculus	160-165
27244099-5	2016	PCR amplification of the TERT promoter region was performed on DNA extracted from formalin-fixed paraffin-embedded tissue using primers5"-GCCGATTCGACCTCTCTCC-3" (forward) and 5"-CAGCGCTGCCTGAAACTC-3" (reverse).	Formaldehyde	82-90	telomerase reverse transcriptase	Homo sapiens	25-29
27278367-3	2016	METHODS: Protein expression of FGFR1-4 was determined by immunohistochemistry on tissue microarrays containing 951 formalin-fixed paraffin embedded OCSCC and OPSCC tissues from the University Medical Center Utrecht and University Medical Center Groningen.	Formaldehyde	115-123	fibroblast growth factor receptor 1	Homo sapiens	31-36
27446412-5	2016	FOXL2 mutational status was evaluated using a pyrosequencing approach on 2.5-microm sections of formalin-fixed paraffin-embedded tissue.	Formaldehyde	96-104	forkhead box L2	Homo sapiens	0-5
27404455-6	2016	In a large validation cohort of 207 patients, nuclear immunostaining of RelB and NF-kappaB2 on formalin-fixed paraffin-embedded specimens was performed.	Formaldehyde	95-103	RELB proto-oncogene, NF-kB subunit	Homo sapiens	72-76
27333219-2	2016	This automated IHC assay has been analytically verified and validated using Dako"s autostainer Link 48 and 22C3 mouse anti-PD-L1 monoclonal antibody to detect the PD-L1 expression in formalin-fixed paraffin-embedded human tumor tissue specimens.	Formaldehyde	183-191	CD274 molecule	Homo sapiens	163-168
27097020-9	2016	Our results show that ATG13 is a static marker of the autophagic flux in 3D models of mesothelioma and may also reflect autophagy levels in formalin-fixed tumor.	Formaldehyde	140-148	autophagy related 13	Homo sapiens	22-27
26951817-5	2016	A whole-transcriptome analysis of heart biopsy specimens and formalin-fixed, paraffin-embedded samples revealed that MIAT was overexpressed in patients with CCC, compared with subjects with noninflammatory dilated cardiomyopathy and controls.	Formaldehyde	61-69	myocardial infarction associated transcript	Homo sapiens	117-121
27466985-3	2016	PATIENTS AND METHODS: We determined the autophagy activity in human Rb tissues by assessing the autophagy markers microtubule-associated protein light chain 3B (LC3) and p62 (SQSTM1) in formalin fixed and paraffin embedded human tissue by immunohistochemistry and then associated their expression with patient clinicopathological features.	Formaldehyde	186-194	RB transcriptional corepressor 1	Homo sapiens	68-70
27466985-3	2016	PATIENTS AND METHODS: We determined the autophagy activity in human Rb tissues by assessing the autophagy markers microtubule-associated protein light chain 3B (LC3) and p62 (SQSTM1) in formalin fixed and paraffin embedded human tissue by immunohistochemistry and then associated their expression with patient clinicopathological features.	Formaldehyde	186-194	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	161-164
27466985-3	2016	PATIENTS AND METHODS: We determined the autophagy activity in human Rb tissues by assessing the autophagy markers microtubule-associated protein light chain 3B (LC3) and p62 (SQSTM1) in formalin fixed and paraffin embedded human tissue by immunohistochemistry and then associated their expression with patient clinicopathological features.	Formaldehyde	186-194	sequestosome 1	Homo sapiens	170-173
27466985-3	2016	PATIENTS AND METHODS: We determined the autophagy activity in human Rb tissues by assessing the autophagy markers microtubule-associated protein light chain 3B (LC3) and p62 (SQSTM1) in formalin fixed and paraffin embedded human tissue by immunohistochemistry and then associated their expression with patient clinicopathological features.	Formaldehyde	186-194	sequestosome 1	Homo sapiens	175-181
26910743-5	2016	We have now improved upon these methods to create a robust assay amenable to high throughput platforms using cytochrome c retention in formaldehyde fixed cells to remove the time sensitivity of JC-1 potential measurements.	Formaldehyde	135-147	cytochrome c, somatic	Homo sapiens	109-121
27347117-0	2016	A comparison of four methods for detecting KRAS mutations in formalin-fixed specimens from metastatic colorectal cancer patients.	Formaldehyde	61-69	KRAS proto-oncogene, GTPase	Homo sapiens	43-47
27342252-5	2016	The S   O chalcogen bond between SF2 and H2CO is the strongest, while the strongest halogen bond is Br   O between SBr2 and H2CO.	Formaldehyde	41-45	serine and arginine rich splicing factor 1	Homo sapiens	33-36
27472713-4	2016	Immunohistochemical analysis of GRO-alpha protein was performed in 160 formalin-fixed, paraffin-embedded PC tissue samples and 68 control specimens, including 37 matched normal surgical margins and 31 benign pancreatic lesions.	Formaldehyde	71-79	C-X-C motif chemokine ligand 1	Homo sapiens	32-41
27311570-5	2016	The expression of PTK6 was detected using immunohistochemical staining in 150 formalin-fixed, paraffin-embedded, early-stage cervical squamous cell cancer sections and 10 normal cervical tissue sections.	Formaldehyde	78-86	protein tyrosine kinase 6	Homo sapiens	18-22
27123778-4	2016	Thus, heating a mixture of 2 and H2 O@2 with hydrogen cyanide and formaldehyde in chlorobenzene affords HCN@2 and H2 CO@2, respectively.	Formaldehyde	66-78	hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2	Homo sapiens	104-109
27079198-0	2016	Expression of miR-146a, miR-155, and miR-223 in formalin-fixed paraffin-embedded synovial tissues of patients with rheumatoid arthritis and osteoarthritis.	Formaldehyde	48-56	microRNA 146a	Homo sapiens	14-22
27144381-3	2016	(i) The numbers of OXT-mRFP1 neurones that expressed Fos-like immunoreactivity (-IR) and OXT-mRFP1 intensity were increased significantly in the magnocellular/parvocellular PVN and SON after s.c. injection of formalin.	Formaldehyde	209-217	oxytocin/neurophysin I prepropeptide	Rattus norvegicus	19-22
27272194-9	2016	In the formalin test, DHC decreased the expression of caspase 6 (CASP6), TNF-alpha, IL-1beta and IL-6 proteins in the spinal cord.	Formaldehyde	7-15	caspase 6	Mus musculus	54-63
27271609-4	2016	In the present study, microRNA-31 expression was measured in formalin-fixed paraffin-embedded (FFPE) biopsies from 78 patients diagnosed with LARC who were treated with neoadjuvant CRT.	Formaldehyde	61-69	microRNA 31	Homo sapiens	22-33
27257141-0	2016	Antibody validation and scoring guidelines for ABCG2 immunohistochemical staining in formalin-fixed paraffin-embedded colon cancer tissue.	Formaldehyde	85-93	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	47-52
26638121-5	2016	AAL injected by intravenous route in mice showed antinociceptive activity in two behavioral tests (writhing and formalin).	Formaldehyde	112-120	active avoidance learning	Mus musculus	0-3
26638121-7	2016	In the formalin test, AAL (0.1 mg/kg) inhibited by 48% the licking time in the inflammatory phase, an effect that was recovered by the lectin association with mannose.	Formaldehyde	7-15	active avoidance learning	Mus musculus	22-25
27068146-1	2016	Sumatriptan, dihydroergotamine and methysergide inhibit 1% formalin-induced nociception by activation of peripheral 5-HT1B/1D receptors.	Formaldehyde	59-67	5-hydroxytryptamine receptor 1B	Rattus norvegicus	116-122
26930003-2	2016	TRPA1 is activated by several inflammatory mediators including formaldehyde and methylglyoxal that are products of the semicarbazide-sensitive amine-oxidase enzyme (SSAO).	Formaldehyde	63-75	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	0-5
26930003-2	2016	TRPA1 is activated by several inflammatory mediators including formaldehyde and methylglyoxal that are products of the semicarbazide-sensitive amine-oxidase enzyme (SSAO).	Formaldehyde	63-75	amine oxidase, copper containing 3	Rattus norvegicus	119-163
26930003-2	2016	TRPA1 is activated by several inflammatory mediators including formaldehyde and methylglyoxal that are products of the semicarbazide-sensitive amine-oxidase enzyme (SSAO).	Formaldehyde	63-75	amine oxidase, copper containing 3	Rattus norvegicus	165-169
27144381-4	2016	(ii) OXT-mRFP1 neurones in the anterior parvocellular PVN, which may project to the dorsal horn of the spinal cord, were activated by s.c. injection of formalin, as indicated by a significant increases of Fos-IR and mRFP1 intensity intensity.	Formaldehyde	152-160	oxytocin/neurophysin I prepropeptide	Rattus norvegicus	5-8
27144381-4	2016	(ii) OXT-mRFP1 neurones in the anterior parvocellular PVN, which may project to the dorsal horn of the spinal cord, were activated by s.c. injection of formalin, as indicated by a significant increases of Fos-IR and mRFP1 intensity intensity.	Formaldehyde	152-160	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	205-208
27144381-5	2016	(iii) Formalin injection caused a significant transient increase in plasma OXT.	Formaldehyde	6-14	oxytocin/neurophysin I prepropeptide	Rattus norvegicus	75-78
27144381-6	2016	(iv) OXT, mRFP1 and corticotrophin-releasing hormone mRNAs in the PVN were significantly increased after s.c. injection of formalin.	Formaldehyde	123-131	oxytocin/neurophysin I prepropeptide	Rattus norvegicus	5-8
26778650-5	2016	AMY (0.06250-2500pmol/rat) was administrated i.t 15min before the injection of formalin.	Formaldehyde	79-87	islet amyloid polypeptide	Rattus norvegicus	0-3
26778650-7	2016	AMY reduced formalin-induced pain in a dose dependent mode.	Formaldehyde	12-20	islet amyloid polypeptide	Rattus norvegicus	0-3
26778650-14	2016	In conclusion, effects of AMY in reducing formalin induced pain and on the cAMP accumulation by spinal cells are mediated through undefined receptors.	Formaldehyde	42-50	islet amyloid polypeptide	Rattus norvegicus	26-29
25193344-0	2016	Assessment of lipid peroxidation and p53 as a biomarker of carcinogenesis among workers exposed to formaldehyde in the cosmetic industry.	Formaldehyde	99-111	tumor protein p53	Homo sapiens	37-40
25193344-2	2016	Our study aimed at assessing the effect of formaldehyde on lipid peroxidation and verifying the susceptibility to carcinogenesis using p53 as a biomarker among workers exposed to formaldehyde in cosmetic industry.	Formaldehyde	179-191	tumor protein p53	Homo sapiens	135-138
27003155-4	2016	Next-generation sequencing (NGS) approaches employing targeted panels for BRCA1/2 to interrogate formalin-fixed and paraffin-embedded tumor samples from either surgical resection or biopsy specimens can overcome these limitations.	Formaldehyde	97-105	BRCA1 DNA repair associated	Homo sapiens	74-81
27267836-4	2016	In this study, we determined the PHGDH protein expression using tissue microarray immunohistochemistry (TMA-IHC) on 193 pairs of formalin-fixed, paraffin-embedded specimens of CRC and adjacent tissues, 25 chronic colitis, 41 low-, and 19 high-grade intraepithelial neoplasia specimens, and we also determined PHGDH mRNA level using quantitative reverse transcription PCR (qRT-PCR) on additional 23 pairs of fresh CRC tissues and adjacent tissues.	Formaldehyde	129-137	phosphoglycerate dehydrogenase	Homo sapiens	33-38
27206660-3	2016	Cannabinoid 1 receptor knockout mice (CB1R-/-) generated on a C57Bl/6 background exhibit hypoalgesia in the hotplate assay and formalin test.	Formaldehyde	127-135	cannabinoid receptor 1 (brain)	Mus musculus	0-22
27140610-5	2016	Moreover, the response of NPW(-/-) mice to either formalin-induced pain stimuli or a live rat (i.e., a potential predator) was abnormal only when they were placed in a novel environment: The mice failed to show the normal species-specific self-protective and aversive reactions.	Formaldehyde	50-58	neuropeptide W	Mus musculus	26-29
27086918-4	2016	Immunohistochemical subcellular localization (IHC) analyses of PD-L1 protein was retrospectively performed on 251 archived formalin fixed and paraffin embedded (FFPE) surgical tissues (66 benign thyroid nodules and 185 PTCs) using a rabbit monoclonal anti-PD-L1 antibody (E1L3N, Cell Signaling Technology) and detected using VECTASTAIN rapid protocol with diaminobenzidine (DAB) as the chromogen.	Formaldehyde	123-131	CD274 molecule	Homo sapiens	63-68
27308263-0	2016	Quantitation of CDH1 promoter methylation in formalin-fixed paraffin-embedded tissues of breast cancer patients using differential high resolution melting analysis.	Formaldehyde	45-53	cadherin 1	Homo sapiens	16-20
27308263-6	2016	MATERIALS AND METHODS: Using differential high resolution melting analysis (D-HRMA), the methylation level of the CDH1 gene promoter was quantified in 98 breast cancer formalin-fixed paraffin-embedded (FFPE) tissues and also 10 fresh frozen normal breast tissues.	Formaldehyde	168-176	cadherin 1	Homo sapiens	114-118
27547499-7	2016	The average flinches and licking time of Hint1-/- mice were more than that of Hint1+/+ mice in formalin test.	Formaldehyde	95-103	histidine triad nucleotide binding protein 1	Mus musculus	41-46
27223112-3	2016	AIMS: The present study was designed to assess the immunohistochemical expression of the ST2 receptor (ST2L/Il-1R) in atherosclerotic plaques of formalin fixed paraffin-embedded internal carotid arteries of patients with and without cerebro-vascular symptoms.	Formaldehyde	145-153	ST2	Homo sapiens	89-92
27223112-3	2016	AIMS: The present study was designed to assess the immunohistochemical expression of the ST2 receptor (ST2L/Il-1R) in atherosclerotic plaques of formalin fixed paraffin-embedded internal carotid arteries of patients with and without cerebro-vascular symptoms.	Formaldehyde	145-153	interleukin 1 receptor like 1	Homo sapiens	103-107
27223112-3	2016	AIMS: The present study was designed to assess the immunohistochemical expression of the ST2 receptor (ST2L/Il-1R) in atherosclerotic plaques of formalin fixed paraffin-embedded internal carotid arteries of patients with and without cerebro-vascular symptoms.	Formaldehyde	145-153	interleukin 1 receptor type 1	Homo sapiens	108-113
27102822-7	2016	A formalin-inactivated enterovirus A71 vaccine can elicit antibodies in R26-hSCARB2 mice, which play effective roles in protecting knockin mice against enterovirus A71 infection as indicated by bioluminescence.	Formaldehyde	2-10	scavenger receptor class B member 2	Homo sapiens	76-83
27206660-3	2016	Cannabinoid 1 receptor knockout mice (CB1R-/-) generated on a C57Bl/6 background exhibit hypoalgesia in the hotplate assay and formalin test.	Formaldehyde	127-135	cannabinoid receptor 1 (brain)	Mus musculus	38-42
27184741-7	2016	RESULTS: Formalin injection caused acute and chronic inflammatory responses including transient local edema, increased levels of inflammatory cytokines, TNF-alpha, and IL-1beta in the blood as well as in the brain, and increased microglia in the brain.	Formaldehyde	9-17	tumor necrosis factor	Rattus norvegicus	153-162
27242871-2	2016	Thirteen ADH genes were identified in melon genome, including 12 ADHs and one formaldehyde dehydrogenease (FDH), designated CmADH1-12 and CmFDH1, in which CmADH1 and CmADH2 have been isolated in Cantaloupe.	Formaldehyde	78-90	alcohol dehydrogenase 1	Cucumis melo	124-130
27242871-2	2016	Thirteen ADH genes were identified in melon genome, including 12 ADHs and one formaldehyde dehydrogenease (FDH), designated CmADH1-12 and CmFDH1, in which CmADH1 and CmADH2 have been isolated in Cantaloupe.	Formaldehyde	78-90	alcohol dehydrogenase 1	Cucumis melo	155-161
27242871-2	2016	Thirteen ADH genes were identified in melon genome, including 12 ADHs and one formaldehyde dehydrogenease (FDH), designated CmADH1-12 and CmFDH1, in which CmADH1 and CmADH2 have been isolated in Cantaloupe.	Formaldehyde	78-90	carbonyl reductase [NADPH] 2	Cucumis melo	166-172
27184741-11	2016	In the P21 rat"s brain of the formalin group, the expression of autism-related gene neurexin 1 (NRXN1), fragile X mental retardation 1 (FMR1), and oxytocin was significantly downregulated, consistent with the gene alteration in ASD.	Formaldehyde	30-38	KRAS proto-oncogene, GTPase	Rattus norvegicus	7-10
27184741-7	2016	RESULTS: Formalin injection caused acute and chronic inflammatory responses including transient local edema, increased levels of inflammatory cytokines, TNF-alpha, and IL-1beta in the blood as well as in the brain, and increased microglia in the brain.	Formaldehyde	9-17	interleukin 1 beta	Rattus norvegicus	168-176
27184741-11	2016	In the P21 rat"s brain of the formalin group, the expression of autism-related gene neurexin 1 (NRXN1), fragile X mental retardation 1 (FMR1), and oxytocin was significantly downregulated, consistent with the gene alteration in ASD.	Formaldehyde	30-38	neurexin 1	Rattus norvegicus	84-94
27622038-3	2016	Here, the expression levels of PD-L1 and CD8(+) T cell infiltration were analyzed by immunohistochemistry (IHC) in formalin fixed paraffin embedded (FFPE) specimens from 167 HCC patients undergoing resection.	Formaldehyde	115-123	CD274 molecule	Homo sapiens	31-36
27184741-11	2016	In the P21 rat"s brain of the formalin group, the expression of autism-related gene neurexin 1 (NRXN1), fragile X mental retardation 1 (FMR1), and oxytocin was significantly downregulated, consistent with the gene alteration in ASD.	Formaldehyde	30-38	neurexin 1	Rattus norvegicus	96-101
27184741-11	2016	In the P21 rat"s brain of the formalin group, the expression of autism-related gene neurexin 1 (NRXN1), fragile X mental retardation 1 (FMR1), and oxytocin was significantly downregulated, consistent with the gene alteration in ASD.	Formaldehyde	30-38	fragile X messenger ribonucleoprotein 1	Rattus norvegicus	104-134
27184741-11	2016	In the P21 rat"s brain of the formalin group, the expression of autism-related gene neurexin 1 (NRXN1), fragile X mental retardation 1 (FMR1), and oxytocin was significantly downregulated, consistent with the gene alteration in ASD.	Formaldehyde	30-38	fragile X messenger ribonucleoprotein 1	Rattus norvegicus	136-140
27178246-5	2016	In our study, FAAH KO mice exhibited a characteristic analgesic phenotype in the tail flick test and in both formalin and carrageenan models of inflammatory nociception.	Formaldehyde	109-117	fatty acid amide hydrolase	Mus musculus	14-18
26898937-5	2016	Among them four novel fusion genes SEPT9/CYHR, IGF1R/TTC23, SYT8/TNNI2 and CASZ1/DFFA were validated and characterized in 48 formalin-fixed paraffin-embedded (FFPE) specimens of bladder cancer.	Formaldehyde	125-133	septin 9	Homo sapiens	35-40
27115465-4	2016	METHODS: CXCL14 mRNA expression was analysed in a breast cancer tissue microarray (TMA) of formalin-fixed, paraffin-embedded tumours by the RNAscope 2.0 Assay.	Formaldehyde	91-99	chemokine (C-X-C motif) ligand 14	Mus musculus	9-15
27215400-3	2016	METHODS: EGFR mutation status was assessed for lung adenocarcinoma samples (formalin fixed- paraffin embedded samples) using qPCR, SNaPshot and NGS (Ion Torrent ) techniques.	Formaldehyde	76-84	epidermal growth factor receptor	Homo sapiens	9-13
26898937-5	2016	Among them four novel fusion genes SEPT9/CYHR, IGF1R/TTC23, SYT8/TNNI2 and CASZ1/DFFA were validated and characterized in 48 formalin-fixed paraffin-embedded (FFPE) specimens of bladder cancer.	Formaldehyde	125-133	insulin like growth factor 1 receptor	Homo sapiens	47-52
26898937-5	2016	Among them four novel fusion genes SEPT9/CYHR, IGF1R/TTC23, SYT8/TNNI2 and CASZ1/DFFA were validated and characterized in 48 formalin-fixed paraffin-embedded (FFPE) specimens of bladder cancer.	Formaldehyde	125-133	tetratricopeptide repeat domain 23	Homo sapiens	53-58
26898937-5	2016	Among them four novel fusion genes SEPT9/CYHR, IGF1R/TTC23, SYT8/TNNI2 and CASZ1/DFFA were validated and characterized in 48 formalin-fixed paraffin-embedded (FFPE) specimens of bladder cancer.	Formaldehyde	125-133	synaptotagmin 8	Homo sapiens	60-64
26898937-5	2016	Among them four novel fusion genes SEPT9/CYHR, IGF1R/TTC23, SYT8/TNNI2 and CASZ1/DFFA were validated and characterized in 48 formalin-fixed paraffin-embedded (FFPE) specimens of bladder cancer.	Formaldehyde	125-133	troponin I2, fast skeletal type	Homo sapiens	65-70
26685864-4	2016	We analyzed the dependence of the ChIP signal on the duration of formaldehyde cross-linking time for two proteins: DNA topoisomerase 1 (Top1) that is functionally associated with the double helix in vivo, especially with active chromatin, and green fluorescent protein (GFP) that has no known bona fide interactions with DNA.	Formaldehyde	65-77	DNA topoisomerase I	Homo sapiens	115-134
26898937-5	2016	Among them four novel fusion genes SEPT9/CYHR, IGF1R/TTC23, SYT8/TNNI2 and CASZ1/DFFA were validated and characterized in 48 formalin-fixed paraffin-embedded (FFPE) specimens of bladder cancer.	Formaldehyde	125-133	castor zinc finger 1	Homo sapiens	75-80
26898937-5	2016	Among them four novel fusion genes SEPT9/CYHR, IGF1R/TTC23, SYT8/TNNI2 and CASZ1/DFFA were validated and characterized in 48 formalin-fixed paraffin-embedded (FFPE) specimens of bladder cancer.	Formaldehyde	125-133	DNA fragmentation factor subunit alpha	Homo sapiens	81-85
26500335-0	2016	Immunohistochemical detection of cytoplasmic nucleophosmin in formalin-fixed paraffin-embedded marrow trephine biopsies in acute myeloid leukaemia.	Formaldehyde	62-70	nucleophosmin 1	Homo sapiens	45-58
26500335-2	2016	In this study, we tested whether immunohistochemical (IHC) detection of cytoplasmic NPM1 (cNPM1) in formalin-fixed bone marrow trephine biopsies correlated with NPM1 mutations and the prognostic impact of NPM1 and fms-related tyrosine kinase 3-internal tandem duplication (FLT3-ITD) gene mutations was also assessed.	Formaldehyde	100-108	nucleophosmin 1	Homo sapiens	84-88
26500335-2	2016	In this study, we tested whether immunohistochemical (IHC) detection of cytoplasmic NPM1 (cNPM1) in formalin-fixed bone marrow trephine biopsies correlated with NPM1 mutations and the prognostic impact of NPM1 and fms-related tyrosine kinase 3-internal tandem duplication (FLT3-ITD) gene mutations was also assessed.	Formaldehyde	100-108	nucleophosmin 1	Homo sapiens	91-95
26500335-2	2016	In this study, we tested whether immunohistochemical (IHC) detection of cytoplasmic NPM1 (cNPM1) in formalin-fixed bone marrow trephine biopsies correlated with NPM1 mutations and the prognostic impact of NPM1 and fms-related tyrosine kinase 3-internal tandem duplication (FLT3-ITD) gene mutations was also assessed.	Formaldehyde	100-108	nucleophosmin 1	Homo sapiens	91-95
26500335-9	2016	CONCLUSIONS: Our results showed that IHC detection of cNPM1 in formalin-fixed trephine biopsies correlated well but not entirely with NPM1 mutation.	Formaldehyde	63-71	nucleophosmin 1	Homo sapiens	55-59
26921540-0	2016	Multicenter Evaluation of a Novel Automated Rapid Detection System of BRAF Status in Formalin-Fixed, Paraffin-Embedded Tissues.	Formaldehyde	85-93	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	70-74
26921540-4	2016	In a multicenter approach, we evaluated a novel and fully automated PCR-based system (Idylla) capable of detecting BRAF V600 mutations in formalin-fixed, paraffin-embedded tissue within 90 minutes with high sensitivity.	Formaldehyde	138-146	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	115-119
26921540-10	2016	In conclusion, the Idylla system is a highly reliable and sensitive platform for detection of BRAF V600 mutations in formalin-fixed, paraffin-embedded material, providing an efficient alternative to conventional diagnostic methods, particularly for routine diagnostics laboratories with limited experience in molecular pathology.	Formaldehyde	117-125	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	94-98
27058448-7	2016	When we screened additional archival formalin-fixed paraffin-embedded (FFPE) congenital cutaneous and hepatic hemangiomas, 4/8 had GNAQ or GNA11 Glu209 variants.	Formaldehyde	37-45	G protein subunit alpha q	Homo sapiens	131-135
26662803-0	2016	Aberrant expression of Notch1, HES1, and DTX1 genes in glioblastoma formalin-fixed paraffin-embedded tissues.	Formaldehyde	68-76	notch receptor 1	Homo sapiens	23-29
26662803-0	2016	Aberrant expression of Notch1, HES1, and DTX1 genes in glioblastoma formalin-fixed paraffin-embedded tissues.	Formaldehyde	68-76	hes family bHLH transcription factor 1	Homo sapiens	31-35
26662803-0	2016	Aberrant expression of Notch1, HES1, and DTX1 genes in glioblastoma formalin-fixed paraffin-embedded tissues.	Formaldehyde	68-76	deltex E3 ubiquitin ligase 1	Homo sapiens	41-45
27015733-4	2016	Following our previous work on the immunogenicity of diphtheria toxin mutant CRM197 and formaldehyde-treated diphtheria toxoid (DT) as carriers for meningococcal A (MenA) conjugates in mouse model, we further investigated the role of the carrier on the immunological response to glycoconjugate vaccines.	Formaldehyde	88-100	ENAH actin regulator	Mus musculus	165-169
26513623-3	2016	We evaluated the utility of a monoclonal antibody directed against glypican 3 (GPC-3), a membrane bound protein involved in regulation of the signaling of Wingless-types (WNTs), Hedgehogs (Hh), Fibroblast Growth Factors (FGFs), and Bone Morphogenetic Proteins (BMPs), in the detection of ganglion cells in formalin-fixed, paraffin-embedded tissue sections.	Formaldehyde	306-314	glypican 3	Homo sapiens	67-77
26513623-3	2016	We evaluated the utility of a monoclonal antibody directed against glypican 3 (GPC-3), a membrane bound protein involved in regulation of the signaling of Wingless-types (WNTs), Hedgehogs (Hh), Fibroblast Growth Factors (FGFs), and Bone Morphogenetic Proteins (BMPs), in the detection of ganglion cells in formalin-fixed, paraffin-embedded tissue sections.	Formaldehyde	306-314	glypican 3	Homo sapiens	79-84
26643896-6	2016	As a result, MTUS1 levels were found to be diminished in formalin-fixed, paraffin-embedded (FFPE) tissue samples of CRC patients compared to controls.	Formaldehyde	57-65	microtubule associated scaffold protein 1	Homo sapiens	13-18
27076758-2	2016	METHODS: PTEN protein expression was assessed by immunohistochemistry in formalin-fixed, paraffin-embedded liver sections of patients with non-alcoholic fatty liver disease (NAFLD) (n = 44) or alcoholic liver disease (ALD) (n = 25).	Formaldehyde	73-81	phosphatase and tensin homolog	Homo sapiens	9-13
28357356-0	2016	Formaldehyde fixation is detrimental to actin cables in glucose-depleted S. cerevisiae cells.	Formaldehyde	0-12	actin	Saccharomyces cerevisiae S288C	40-45
28357356-9	2016	A similar overlapping "patchy" pattern of both actin markers was observed upon treatment of glucose-deprived rho+ cells with FCCP (the inhibitor of oxidative phosphorylation) and upon treatment with formaldehyde.	Formaldehyde	199-211	actin	Saccharomyces cerevisiae S288C	47-52
27092059-5	2016	For this purpose, we used a highly sensitive immunohistochemistry (IHC) technique to identify tyrosine hydroxylase (TH; EC 1.14.16.2), a marker for striatal dopaminergic axons and terminals, in formalin-fixed paraffin-embedded (FFPE) tissues obtained from autopsied human brains.	Formaldehyde	194-202	tyrosine hydroxylase	Homo sapiens	94-114
27092059-5	2016	For this purpose, we used a highly sensitive immunohistochemistry (IHC) technique to identify tyrosine hydroxylase (TH; EC 1.14.16.2), a marker for striatal dopaminergic axons and terminals, in formalin-fixed paraffin-embedded (FFPE) tissues obtained from autopsied human brains.	Formaldehyde	194-202	tyrosine hydroxylase	Homo sapiens	116-118
26806571-6	2016	In in vivo experiments, the efficacy of PAF-EA was evaluated at the doses of 100 and 200mg/kg using several chemical-induced models of inflammatory pain such as acetic acid-induced writhing, formalin-induced paw licking and edema.	Formaldehyde	191-199	patchy fur	Mus musculus	40-46
26891729-1	2016	therascreen( ) EGFR RGQ PCR Kit is a real-time polymerase chain reaction test kit for the qualitative detection of exon 19 deletions and L858R mutation of the human EGFR gene in formalin-fixed paraffin-embedded non-small cell lung cancer (NSCLC) tissue.	Formaldehyde	178-186	epidermal growth factor receptor	Homo sapiens	15-19
26511814-5	2016	Formalin-fixed paraffin-embedded tumor samples were stained with monoclonal antibody (clone 5H1) to PD-L1.	Formaldehyde	0-8	CD274 molecule	Homo sapiens	100-105
26626802-0	2016	Droplet digital polymerase chain reaction detection of HER2 amplification in formalin fixed paraffin embedded breast and gastric carcinoma samples.	Formaldehyde	77-85	erb-b2 receptor tyrosine kinase 2	Homo sapiens	55-59
27126659-0	2016	Detection of SYT-SSX mutant transcripts in formalin-fixed paraffin-embedded sarcoma tissues using one-step reverse transcriptase real-time PCR.	Formaldehyde	43-51	synaptotagmin 1	Homo sapiens	13-16
27126659-0	2016	Detection of SYT-SSX mutant transcripts in formalin-fixed paraffin-embedded sarcoma tissues using one-step reverse transcriptase real-time PCR.	Formaldehyde	43-51	SSX family member 2	Homo sapiens	17-20
26891729-1	2016	therascreen( ) EGFR RGQ PCR Kit is a real-time polymerase chain reaction test kit for the qualitative detection of exon 19 deletions and L858R mutation of the human EGFR gene in formalin-fixed paraffin-embedded non-small cell lung cancer (NSCLC) tissue.	Formaldehyde	178-186	epidermal growth factor receptor	Homo sapiens	165-169
26922550-1	2016	BACKGROUND: The purpose of this study was to determine the role of spinal 5-HT2A, 5-HT2B and 5-HT2C receptors in the development and maintenance of formalin-induced long-lasting secondary allodynia and hyperalgesia in rats, as well as their expression in the dorsal root ganglia (DRG) during this process.	Formaldehyde	148-156	5-hydroxytryptamine receptor 2A	Rattus norvegicus	74-80
26656630-4	2016	Formalin-inactivated RSV immune mice showed high levels of pulmonary inflammatory cytokines, macrophages, IL-4-producing T cells, and extensive histopathology.	Formaldehyde	0-8	interleukin 4	Mus musculus	106-110
26944829-4	2016	Confocal immunofluorescence of formalin and paraffin-embedded tissue was used to access the subcellular localization of EGFR.	Formaldehyde	31-39	epidermal growth factor receptor	Canis lupus familiaris	120-124
26922550-11	2016	CONCLUSION: Data suggest that spinal 5-HT2A/2B/2C receptors have pronociceptive effects and participate in the development and maintenance of formalin-induced long-lasting hypersensitivity.	Formaldehyde	142-150	5-hydroxytryptamine receptor 2A	Rattus norvegicus	37-43
26782630-4	2016	The expression and significance of IDH2 were investigated by immunohistochemistry in formalin-fixed paraffin sections from 44 osteosarcoma patients.	Formaldehyde	85-93	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	35-39
26931162-0	2016	A simple and sensitive flow injection method based on the catalytic activity of CdS quantum dots in an acidic permanganate chemiluminescence system for determination of formaldehyde in water and wastewater.	Formaldehyde	169-181	CDP-diacylglycerol synthase 1	Homo sapiens	80-83
26931162-1	2016	A simple and sensitive flow injection chemiluminescence (CL) method in which CdS quantum dots (QDs) enhanced the CL intensity of a KMnO4-formaldehyde (HCHO) reaction was offered for the determination of HCHO.	Formaldehyde	137-149	CDP-diacylglycerol synthase 1	Homo sapiens	77-80
26922550-1	2016	BACKGROUND: The purpose of this study was to determine the role of spinal 5-HT2A, 5-HT2B and 5-HT2C receptors in the development and maintenance of formalin-induced long-lasting secondary allodynia and hyperalgesia in rats, as well as their expression in the dorsal root ganglia (DRG) during this process.	Formaldehyde	148-156	5-hydroxytryptamine receptor 2B	Rattus norvegicus	82-88
26922550-1	2016	BACKGROUND: The purpose of this study was to determine the role of spinal 5-HT2A, 5-HT2B and 5-HT2C receptors in the development and maintenance of formalin-induced long-lasting secondary allodynia and hyperalgesia in rats, as well as their expression in the dorsal root ganglia (DRG) during this process.	Formaldehyde	148-156	5-hydroxytryptamine receptor 2C	Rattus norvegicus	93-99
26922550-9	2016	Formalin injection (1%) increased bilaterally 5-HT2A/2B receptors expression in DRG.	Formaldehyde	0-8	5-hydroxytryptamine receptor 2A	Rattus norvegicus	46-52
26922550-10	2016	In contrast, formalin injection decreased 5-HT2C receptors expression bilaterally in DRG.	Formaldehyde	13-21	5-hydroxytryptamine receptor 2C	Rattus norvegicus	42-48
26956379-5	2016	In addition, FGF23 mRNA expression was detected by reverse transcription-polymerase chain reaction (RT-PCR), using RNA extracted from formalin-fixed, paraffin-embedded tissues.	Formaldehyde	134-142	fibroblast growth factor 23	Homo sapiens	13-18
27030720-5	2016	RESULTS: Nociceptive behavioral response increased in phase II of the formalin test, particularly during the later stage (26-50 min) in NIPSNAP1-deficient mice, although the response during phase I (0-15 min) was not significantly different between the deficient and wild-type mice.	Formaldehyde	70-78	nipsnap homolog 1	Mus musculus	136-144
27099512-4	2016	METHODS: Immunohistochemistry was performed to examine the subcellular localization and the expression level of ZEB1 protein in 82 self-pairs of formalin-fixed and paraffin-embedded cancerous and adjacent noncancerous tissues obtained from patients with thyroid cancer.	Formaldehyde	145-153	zinc finger E-box binding homeobox 1	Homo sapiens	112-116
27030720-9	2016	In the formalin test, NIPSNAP1 mRNA was slightly increased in dorsal root ganglion but not in the spinal cord.	Formaldehyde	7-15	nipsnap homolog 1	Mus musculus	22-30
26870894-8	2016	In contrast, the expression of IL-4/13B1 and IL-4/13B2 is low constitutively but is highly induced by viral haemorrhagic septicaemia virus (VHSH) infection and during proliferative kidney disease (PKD) in vivo, and by formalin-killed bacteria, PAMPs, the T cell mitogen PHA, and the T-cell cytokines IL-2 and IL-21 in vitro.	Formaldehyde	218-226	interleukin 4	Danio rerio	31-35
26870894-8	2016	In contrast, the expression of IL-4/13B1 and IL-4/13B2 is low constitutively but is highly induced by viral haemorrhagic septicaemia virus (VHSH) infection and during proliferative kidney disease (PKD) in vivo, and by formalin-killed bacteria, PAMPs, the T cell mitogen PHA, and the T-cell cytokines IL-2 and IL-21 in vitro.	Formaldehyde	218-226	interleukin 4	Danio rerio	45-49
26937014-3	2016	Here, we found that spinal TET1 and TET3 were significantly increased in the model of formalin-induced acute inflammatory pain, which was accompanied with the augment of genome-wide 5hmC content in spinal cord.	Formaldehyde	86-94	tet methylcytosine dioxygenase 1	Mus musculus	27-31
26937014-3	2016	Here, we found that spinal TET1 and TET3 were significantly increased in the model of formalin-induced acute inflammatory pain, which was accompanied with the augment of genome-wide 5hmC content in spinal cord.	Formaldehyde	86-94	tet methylcytosine dioxygenase 3	Mus musculus	36-40
26937014-4	2016	Knockdown of spinal TET1 or TET3 alleviated the formalin-induced nociceptive behavior and overexpression of spinal TET1 or TET3 in naive mice produced pain-like behavior as evidenced by decreased thermal pain threshold.	Formaldehyde	48-56	tet methylcytosine dioxygenase 1	Mus musculus	20-24
26937014-4	2016	Knockdown of spinal TET1 or TET3 alleviated the formalin-induced nociceptive behavior and overexpression of spinal TET1 or TET3 in naive mice produced pain-like behavior as evidenced by decreased thermal pain threshold.	Formaldehyde	48-56	tet methylcytosine dioxygenase 3	Mus musculus	28-32
26937014-6	2016	Formalin increased 5hmC in the miR-365-3p promoter, which was inhibited by knockdown of TET1 or TET3 and mimicked by overexpression of TET1 or TET3 in naive mice.	Formaldehyde	0-8	tet methylcytosine dioxygenase 1	Mus musculus	88-92
26937014-6	2016	Formalin increased 5hmC in the miR-365-3p promoter, which was inhibited by knockdown of TET1 or TET3 and mimicked by overexpression of TET1 or TET3 in naive mice.	Formaldehyde	0-8	tet methylcytosine dioxygenase 3	Mus musculus	96-100
26937014-6	2016	Formalin increased 5hmC in the miR-365-3p promoter, which was inhibited by knockdown of TET1 or TET3 and mimicked by overexpression of TET1 or TET3 in naive mice.	Formaldehyde	0-8	tet methylcytosine dioxygenase 1	Mus musculus	135-139
26937014-6	2016	Formalin increased 5hmC in the miR-365-3p promoter, which was inhibited by knockdown of TET1 or TET3 and mimicked by overexpression of TET1 or TET3 in naive mice.	Formaldehyde	0-8	tet methylcytosine dioxygenase 3	Mus musculus	143-147
26548970-6	2016	introduction of Rb1 significantly decreased nociceptive behavior during phase II (16-60 minutes), but not phase I (0-10 minutes), after formalin stimulation, corresponding to the reduced activation of c-Fos in the L4 to L5 spinal dorsal horn after formalin stimulation.	Formaldehyde	136-144	RB transcriptional corepressor 1	Rattus norvegicus	16-19
26453693-5	2016	EXPERIMENTAL DESIGN: Immunohistochemistry for tumor expression of CXCL12 was assessed as a biomarker of relapse alongside vascular invasion, histology (percentage embryonal carcinoma), and MIB1 staining for proliferation in formalin-fixed paraffin-embedded orchidectomy samples from patients enrolled in the Medical Research Council"s TE08/22 prospective trials of surveillance in stage I NSGCTs.	Formaldehyde	224-232	C-X-C motif chemokine ligand 12	Homo sapiens	66-72
27065677-5	2016	Immunohistochemistry (IHC) was carried out on all the cases to evaluate the expression of HER2 in formalin-fixed paraffin-embedded tissue samples.	Formaldehyde	98-106	erb-b2 receptor tyrosine kinase 2	Homo sapiens	90-94
26648569-4	2016	Immunohistochemistry (IHC) for Arpin protein was performed on formalin-fixed, paraffin-embedded 176 breast cancer tissues and 43 normal breast tissues while qRT-PCR for Arpin mRNA with 104 paired tumour and paratumoural tissues from breast cancer patients respectively.	Formaldehyde	62-70	actin related protein 2/3 complex inhibitor	Homo sapiens	31-36
27276194-2	2016	Pharmacological treatment with the potent, selective and structurally distinct dual orexin receptor antagonists (ORAs) DORA-12 and DORA-2 significantly reduced pain responses during both phases I and II of the mouse formalin pain model and significantly reversed hyperalgesia in the rat complete Freund"s adjuvant pain model, respectively.	Formaldehyde	216-224	hypocretin	Mus musculus	84-90
26548970-6	2016	introduction of Rb1 significantly decreased nociceptive behavior during phase II (16-60 minutes), but not phase I (0-10 minutes), after formalin stimulation, corresponding to the reduced activation of c-Fos in the L4 to L5 spinal dorsal horn after formalin stimulation.	Formaldehyde	248-256	RB transcriptional corepressor 1	Rattus norvegicus	16-19
26548970-12	2016	introduction of Rb1 might effectively inhibit formalin-induced acute inflammatory nociception by inhibition of neuronal extracellular signal-regulated kinase phosphorylation, which is thought to regulate the nuclear factor erythroid 2-related factor 2 nuclear factor kappa B pathways in the spinal dorsal horn, which suggests therapeutic potential for suppression of acute inflammatory pain.	Formaldehyde	46-54	RB transcriptional corepressor 1	Rattus norvegicus	16-19
26548970-12	2016	introduction of Rb1 might effectively inhibit formalin-induced acute inflammatory nociception by inhibition of neuronal extracellular signal-regulated kinase phosphorylation, which is thought to regulate the nuclear factor erythroid 2-related factor 2 nuclear factor kappa B pathways in the spinal dorsal horn, which suggests therapeutic potential for suppression of acute inflammatory pain.	Formaldehyde	46-54	NFE2 like bZIP transcription factor 2	Rattus norvegicus	208-251
26880641-7	2016	At that time we showed that purified DMGDH, with tightly bound THF, reacted with formaldehyde generated during the reaction to form 5,10-methylene-THF.	Formaldehyde	81-93	dimethylglycine dehydrogenase	Homo sapiens	37-42
26880641-14	2016	The mechanism of LSD1 demethylation is analogous to the mechanism previously postulated for DMGDH, i.e. oxidation of the N-methyl bond to the methylene imine followed by hydrolysis to generate formaldehyde.	Formaldehyde	193-205	dimethylglycine dehydrogenase	Homo sapiens	92-97
26880641-15	2016	This suggested that THF might also be involved in the LSD1 reaction to scavenge the formaldehyde produced.	Formaldehyde	84-96	lysine demethylase 1A	Homo sapiens	54-58
26880641-14	2016	The mechanism of LSD1 demethylation is analogous to the mechanism previously postulated for DMGDH, i.e. oxidation of the N-methyl bond to the methylene imine followed by hydrolysis to generate formaldehyde.	Formaldehyde	193-205	lysine demethylase 1A	Homo sapiens	17-21
26880641-18	2016	This can be a result of decreased LSD1 activity resulting from the decreased folate available to scavenge the formaldehyde produced at the active site caused by the folate deficiency.	Formaldehyde	110-122	lysine demethylase 1A	Homo sapiens	34-38
26932717-9	2016	Allyl nitrile elevated SOD levels for the 3 sensitizers, and CAT levels for formaldehyde and DNCB.	Formaldehyde	76-88	catalase	Mus musculus	61-64
26998141-5	2016	miR-711 was found to be upregulated in 30 formalin-fixed paraffin-embedded breast cancer tissue samples compared with paired non-cancerous breast tissues (P&lt;0.05).	Formaldehyde	42-50	microRNA 711	Homo sapiens	0-7
26958083-4	2016	The expression of PD-L1 was evaluated using an anti-PD-L1 immunohistochemistry (IHC) antibody optimized for staining of formalin-fixed paraffin-embedded (FFPE) tissue samples.	Formaldehyde	120-128	CD274 molecule	Homo sapiens	18-23
26216055-5	2016	The number of formalin-induced FRB 15-30 min after the formalin injection was significantly higher in IB4-Sap-treated rats than in Sal- or Bl-Sap-treated rats, and was associated with an increase in c-Fos-IR cells.	Formaldehyde	14-22	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	199-204
26397759-3	2016	The time spent licking the formalin-injected paw was recorded in CD1 mice after pretreatment with increasing doses of WSE.	Formaldehyde	27-35	CD1 antigen complex	Mus musculus	65-68
26397759-6	2016	WSE reduced the antinociceptive response during the tonic but not the acute phase of the formalin test and decreased formalin-induced c-Fos expression in spinal neurons.	Formaldehyde	117-125	FBJ osteosarcoma oncogene	Mus musculus	134-139
26907767-8	2016	Immunohistochemical staining on formalin-fixed paraffin-embedded tissues available in our cohort of patients confirmed higher PYGM expression in normal breast tissue compared to equivalent tumoral zone.	Formaldehyde	32-40	glycogen phosphorylase, muscle associated	Homo sapiens	126-130
26944953-2	2016	The expression of Lin28A and AR in formalin-fixed and paraffin-embedded surgical sections from 305 patients with ER-/Her2+ breast cancer was analyzed by immunohistochemistry, and the co-expression patterns in breast cancer cells were investigated by immunofluorescent staining.	Formaldehyde	35-43	lin-28 homolog A	Homo sapiens	18-24
26944953-2	2016	The expression of Lin28A and AR in formalin-fixed and paraffin-embedded surgical sections from 305 patients with ER-/Her2+ breast cancer was analyzed by immunohistochemistry, and the co-expression patterns in breast cancer cells were investigated by immunofluorescent staining.	Formaldehyde	35-43	androgen receptor	Homo sapiens	29-31
26510178-6	2016	The amplitude of ASIC currents in these neurons increased 119.72% (for ASIC1-like current) and 230.59% (for ASIC3-like current) in the formalin-induced orofacial inflammatory pain model.	Formaldehyde	135-143	acid sensing ion channel subunit 3	Rattus norvegicus	108-113
26795218-1	2016	PURPOSE: To evaluate the clinical value of immunohistochemistry (IHC) using anti-BRAF V600E antibody (clone VE1) for specific detection of the BRAF V600E mutant protein in formalin-fixed paraffin-embedded papillary thyroid carcinoma (PTC) specimens.	Formaldehyde	172-180	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	81-85
26795218-1	2016	PURPOSE: To evaluate the clinical value of immunohistochemistry (IHC) using anti-BRAF V600E antibody (clone VE1) for specific detection of the BRAF V600E mutant protein in formalin-fixed paraffin-embedded papillary thyroid carcinoma (PTC) specimens.	Formaldehyde	172-180	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	143-147
26925122-3	2016	MATERIAL AND METHODS: The immunohistochemical method was used to examine the immunoexpression of ADAM33 in 39 formalin-fixed, paraffin-embedded tissue specimens of sinonasal inverted papillomas (IP), 44 laryngeal squamous cell carcinomas (GI grade = 11, GII grade = 33) and 14 disease-free tissue specimens as a control.	Formaldehyde	110-118	ADAM metallopeptidase domain 33	Homo sapiens	97-103
26551198-0	2016	Effects of formaldehyde exposure on anxiety-like and depression-like behavior, cognition, central levels of glucocorticoid receptor and tyrosine hydroxylase in mice.	Formaldehyde	11-23	nuclear receptor subfamily 3, group C, member 1	Mus musculus	108-131
26551198-5	2016	Inhalation of 2 ppm formaldehyde reduced body weight, but increased levels of depression-like behavior, impaired novel object recognition, and lowered the numbers of glucocorticoid receptor immonureactive neurons in the hippocampus and tyrosine hydroxylase immonureactive neurons in the ventral tegmental area and the zona incerta, medial preoptic area.	Formaldehyde	20-32	nuclear receptor subfamily 3, group C, member 1	Mus musculus	166-189
26687806-4	2016	MATERIALS AND METHODS: We investigated the prevalence of ALDH1A3(+)/CD44(+) cells in a cohort of 144 formalin-fixed, paraffin-embedded (FFPE) breast cancer tissues.	Formaldehyde	101-109	aldehyde dehydrogenase family 1, subfamily A3	Mus musculus	57-64
26676972-8	2016	Locked nucleic acid in situ hybridization showed increased staining of miR-15b in formalin-fixed paraffin-embedded sections of aMCL.	Formaldehyde	82-90	microRNA 15b	Homo sapiens	71-78
26400731-0	2016	Formaldehyde-induced paxillin-tyrosine phosphorylation and paxillin and P53 downexpression in Hela cells.	Formaldehyde	0-12	paxillin	Homo sapiens	21-29
26400731-0	2016	Formaldehyde-induced paxillin-tyrosine phosphorylation and paxillin and P53 downexpression in Hela cells.	Formaldehyde	0-12	paxillin	Homo sapiens	59-67
26400731-0	2016	Formaldehyde-induced paxillin-tyrosine phosphorylation and paxillin and P53 downexpression in Hela cells.	Formaldehyde	0-12	tumor protein p53	Homo sapiens	72-75
26420831-0	2016	ATM and KAT5 safeguard replicating chromatin against formaldehyde damage.	Formaldehyde	53-65	ATM serine/threonine kinase	Homo sapiens	0-3
26812617-0	2016	Validation of a Multiplex Allele-Specific Polymerase Chain Reaction Assay for Detection of KRAS Gene Mutations in Formalin-Fixed, Paraffin-Embedded Tissues from Colorectal Cancer Patients.	Formaldehyde	114-122	KRAS proto-oncogene, GTPase	Homo sapiens	91-95
26654362-6	2016	In vitro formaldehyde cross-linking studies also conclusively show that cis-interacting claudin-5 dimers cross-link with short methylene spacers.	Formaldehyde	9-21	claudin 5	Homo sapiens	88-97
26751376-6	2016	MTAP expression was also evaluated in two groups of samples from breast cancer patients, fresh tumors and paired normal breast tissue, and from formalin-fixed paraffin embedded (FFPE) core breast cancer samples diagnosed as Luminal-A tumors and triple negative breast tumors (TNBC).	Formaldehyde	144-152	methylthioadenosine phosphorylase	Homo sapiens	0-4
26420831-0	2016	ATM and KAT5 safeguard replicating chromatin against formaldehyde damage.	Formaldehyde	53-65	lysine acetyltransferase 5	Homo sapiens	8-12
26731648-0	2016	Improving the Prediction of Prostate Cancer Overall Survival by Supplementing Readily Available Clinical Data with Gene Expression Levels of IGFBP3 and F3 in Formalin-Fixed Paraffin Embedded Core Needle Biopsy Material.	Formaldehyde	158-166	insulin like growth factor binding protein 3	Homo sapiens	141-147
26588055-4	2016	We found that expression of miR-671-5p was decreased significantly in invasive ductal carcinoma (IDC) compared to normal in microdissected formalin-fixed, paraffin-embedded (FFPE) tissues.	Formaldehyde	139-147	microRNA 671	Homo sapiens	28-35
26588579-3	2016	METHODS: This study assessed the HDAC1 expressions in 90 formalin-fixed paraffin-embedded LSCC samples, 30 adjacent non-neoplastic tissues, and 30 laryngeal polyp tissues by immunohistochemistry (IHC).	Formaldehyde	57-65	histone deacetylase 1	Homo sapiens	33-38
26900062-3	2016	When the cancer cells metastasized into bone marrow, the elevated endogenous formaldehyde induced bone cancer pain through activation on the transient receptor potential vanilloid subfamily member 1 (TRPV1) in the peripheral nerve fibers.	Formaldehyde	77-89	transient receptor potential cation channel subfamily V member 1	Homo sapiens	200-205
26900062-5	2016	In conclusion, tumor tissue-derived endogenous formaldehyde induced bone cancer pain via TRPV1 activation.	Formaldehyde	47-59	transient receptor potential cation channel subfamily V member 1	Homo sapiens	89-94
26900062-0	2016	New Mechanism of Bone Cancer Pain: Tumor Tissue-Derived Endogenous Formaldehyde Induced Bone Cancer Pain via TRPV1 Activation.	Formaldehyde	67-79	transient receptor potential cation channel subfamily V member 1	Homo sapiens	109-114
27545000-0	2016	Plantar injection of formalin in rats reduces the expression of a potassium chroride cotransporter KCC2 in the spinal cord and a kinase inhibitor suppresses this reduction.	Formaldehyde	21-29	solute carrier family 12 member 5	Rattus norvegicus	99-103
26900062-2	2016	We found that cancer cells produced formaldehyde through demethylation process by serine hydroxymethyltransferase (SHMT1 and SHMT2) and lysine-specific histone demethylase 1 (LSD1).	Formaldehyde	36-48	serine hydroxymethyltransferase 1	Homo sapiens	115-120
26900062-2	2016	We found that cancer cells produced formaldehyde through demethylation process by serine hydroxymethyltransferase (SHMT1 and SHMT2) and lysine-specific histone demethylase 1 (LSD1).	Formaldehyde	36-48	serine hydroxymethyltransferase 2	Homo sapiens	125-130
26900062-2	2016	We found that cancer cells produced formaldehyde through demethylation process by serine hydroxymethyltransferase (SHMT1 and SHMT2) and lysine-specific histone demethylase 1 (LSD1).	Formaldehyde	36-48	lysine demethylase 1A	Homo sapiens	136-173
26900062-2	2016	We found that cancer cells produced formaldehyde through demethylation process by serine hydroxymethyltransferase (SHMT1 and SHMT2) and lysine-specific histone demethylase 1 (LSD1).	Formaldehyde	36-48	lysine demethylase 1A	Homo sapiens	175-179
27545000-2	2016	Previous studies reported that KCC2 is downregulated 5 min after the plantar injection of formalin in rats; however, the mechanism behind this decrease in KCC2 expression during acute inflammatory pain remains unknown.	Formaldehyde	90-98	solute carrier family 12 member 5	Rattus norvegicus	31-35
27545000-4	2016	Five minutes after the plantar injection of formalin in rats, the ratio of KCC2-immunoreactive area in layer II of the spinal cord significantly decreased on the stimulated side compared to the unaffected side.	Formaldehyde	44-52	solute carrier family 12 member 5	Rattus norvegicus	75-79
26585927-4	2016	We developed an anaplastic lymphoma kinase (ALK) protein assay that uses multiplexed selected reaction monitoring (SRM) to quantify absolute amounts of ALK in formalin-fixed paraffin-embedded (FFPE) tumor tissue.	Formaldehyde	159-167	ALK receptor tyrosine kinase	Homo sapiens	16-42
25943321-3	2016	MATERIALS AND METHODS: Pyrosequencing was used to identify KRAS mutation and hypermethylation of 6 CpG island loci (p16, p14, MINT1, MINT2, MINT31, and hMLH1) in DNA extracted from formalin-fixed paraffin-embedded specimens.	Formaldehyde	181-189	KRAS proto-oncogene, GTPase	Homo sapiens	59-63
26585927-4	2016	We developed an anaplastic lymphoma kinase (ALK) protein assay that uses multiplexed selected reaction monitoring (SRM) to quantify absolute amounts of ALK in formalin-fixed paraffin-embedded (FFPE) tumor tissue.	Formaldehyde	159-167	ALK receptor tyrosine kinase	Homo sapiens	44-47
26585927-4	2016	We developed an anaplastic lymphoma kinase (ALK) protein assay that uses multiplexed selected reaction monitoring (SRM) to quantify absolute amounts of ALK in formalin-fixed paraffin-embedded (FFPE) tumor tissue.	Formaldehyde	159-167	ALK receptor tyrosine kinase	Homo sapiens	152-155
27034530-3	2016	Fourteen TIO cases were retrieved and FGF23 expression was measured by quantitative ELISA-like immunohistochemistry using formalin-fixed and paraffin-embedded tissues.	Formaldehyde	122-130	fibroblast growth factor 23	Homo sapiens	38-43
27647987-4	2016	Immunohistochemistry analysis of MMP-13 was performed on formalin-fixed, paraffin-embedded sections of cancerous breast tissue (n = 76) and normal breast tissue (n = 20), all of which had clinicopathological information available.	Formaldehyde	57-65	matrix metallopeptidase 13	Homo sapiens	33-39
27034530-7	2016	The quantitative ELISA-like immunohistochemistry was a feasible and reproducible procedure to detect the high FGF23 expression in formalin-fixed and paraffin-embedded biopsies or specimens.	Formaldehyde	130-138	fibroblast growth factor 23	Homo sapiens	110-115
29791105-1	2016	Experiments on inflammatory edema modeling by sub-plantar injection of carrageenan lambda (1 %) and formalin (2 %) showed substantial differences betwe- en the two models during long-term observation, including irreversible damage caused by formalin (at reversible carrageenan action) and high intensity of for- malin edema (in contrast to carrageenan edema) in mice.	Formaldehyde	241-249	NHL repeat containing 1	Mus musculus	103-108
26820945-0	2016	Evaluation of Human Epidermal Growth Factor Receptor 2 (HER2) Gene Status in Human Breast Cancer Formalin-Fixed Paraffin-Embedded (FFPE) Tissue Specimens by Fluorescence In Situ Hybridization (FISH).	Formaldehyde	97-105	erb-b2 receptor tyrosine kinase 2	Homo sapiens	14-54
26577303-12	2016	Relative abundance of ATRX was assessed by confocal laser scanning microscopy (CLSM) of whole mount formaldehyde fixed oocytes or after removal of zona and spreading.	Formaldehyde	100-112	ATRX, chromatin remodeler	Mus musculus	22-26
26882358-4	2016	This is the first case of Denys Drash Syndrome with the uncommon missense c.1097G&gt;A [p.(Arg366His)] mutation in the WT1 gene which has been diagnosed on long-term stored formalin-fixed paraffin-embedded tissue in 1993.	Formaldehyde	173-181	WT1 transcription factor	Homo sapiens	119-122
26202929-0	2016	A new monoclonal antibody (CAL2) detects CALRETICULIN mutations in formalin-fixed and paraffin-embedded bone marrow biopsies.	Formaldehyde	67-75	calbindin 2	Homo sapiens	27-31
26202929-0	2016	A new monoclonal antibody (CAL2) detects CALRETICULIN mutations in formalin-fixed and paraffin-embedded bone marrow biopsies.	Formaldehyde	67-75	calreticulin	Homo sapiens	41-53
26820945-0	2016	Evaluation of Human Epidermal Growth Factor Receptor 2 (HER2) Gene Status in Human Breast Cancer Formalin-Fixed Paraffin-Embedded (FFPE) Tissue Specimens by Fluorescence In Situ Hybridization (FISH).	Formaldehyde	97-105	erb-b2 receptor tyrosine kinase 2	Homo sapiens	56-60
26285647-10	2016	Immunohistochemical (IHC) staining of PDCD4, one of the signature proteins, on an independent set of formalin-fixed paraffin-embedded tumor tissues provided and independent technical validation (HR = 0.72; 95% CI = 0.57 to 0.92; multivariate Cox regression p value = 0.009).	Formaldehyde	101-109	programmed cell death 4	Homo sapiens	38-43
26422389-3	2016	METHODS: Using selected reaction monitoring mass spectrometry (SRM-MS), we quantified HER2 protein levels in formalin-fixed, paraffin-embedded (FFPE) tissue samples that had been classified as HER2 0, 1+, 2+ or 3+ by immunohistochemistry (IHC).	Formaldehyde	109-117	erb-b2 receptor tyrosine kinase 2	Homo sapiens	86-90
28242880-0	2016	The protective effects of erythropoietin on photoreceptor damage by formaldehyde.	Formaldehyde	68-80	erythropoietin	Rattus norvegicus	26-40
28242880-4	2016	OBJECTIVES: The aim of this study was to survey the effect of erythropoietin on retro bulbar formaldehyde injected photoreceptor layer of rat retina.	Formaldehyde	93-105	erythropoietin	Rattus norvegicus	62-76
26335532-4	2016	The patients were genotyped by classical sequencing, and mTOR pathway activity was assessed by immunochemistry on formalin-fixed paraffin-embedded samples (PTEN/pPTEN/pAKT/pmTOR/pS6/p4EBP1).	Formaldehyde	114-122	mechanistic target of rapamycin kinase	Homo sapiens	57-61
27020207-6	2016	The PIK3CA mutation was evaluated using the PNAClamp Detection Kit from DNA samples extracted from formalin fixed, paraffin embedded tissue.	Formaldehyde	99-107	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	4-10
26450751-5	2016	SUBJECTS AND METHODS: Expression patterns of FGF19 protein in 100 paired formalin-fixed and paraffin-embedded cancerous and adjacent noncancerous tissues from patients with thyroid cancer were detected by immunohistochemistry.	Formaldehyde	73-81	fibroblast growth factor 19	Homo sapiens	45-50
26240388-6	2015	To demonstrate the clinical applicability of our assay, we show specific detection of a point mutation in the EGFR gene in fresh frozen and formalin-fixed, paraffin-embedded (FFPE) lung cancer samples and confirm the detected mutation by in situ sequencing.	Formaldehyde	140-148	epidermal growth factor receptor	Homo sapiens	110-114
27516024-0	2016	Allele-specific PCR method for identification of EGFR mutations in non-small cell lung cancer: formalin-fixed paraffin-embedded tissue versus fresh tissue.	Formaldehyde	95-103	epidermal growth factor receptor	Homo sapiens	49-53
27516024-2	2016	The aim of this study was to identify patients with EGFR mutations using allele-specific polymerase chain reaction (PCR), from formalin-fixed paraffin-embedded (FFPE) tissue and fresh tissue (FT).	Formaldehyde	127-135	epidermal growth factor receptor	Homo sapiens	52-56
26631948-2	2016	Mutations in exon 11 of c-KIT were examined in 46 formalin-fixed paraffin-embedded canine GISTs using PCR of genomic DNA and reverse transcription-PCR (RT-PCR) of cDNA.	Formaldehyde	50-58	KIT proto-oncogene, receptor tyrosine kinase	Canis lupus familiaris	24-29
27014812-6	2016	CONCLUSION: Formaldehyde exposure can cause imbalance between Th1 and Th2 cytokines secreted by 16HBE cells, as well as increased expression of IL-8 and TNF-alpha.	Formaldehyde	12-24	negative elongation factor complex member C/D	Homo sapiens	62-65
27014812-6	2016	CONCLUSION: Formaldehyde exposure can cause imbalance between Th1 and Th2 cytokines secreted by 16HBE cells, as well as increased expression of IL-8 and TNF-alpha.	Formaldehyde	12-24	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
27014812-6	2016	CONCLUSION: Formaldehyde exposure can cause imbalance between Th1 and Th2 cytokines secreted by 16HBE cells, as well as increased expression of IL-8 and TNF-alpha.	Formaldehyde	12-24	tumor necrosis factor	Homo sapiens	153-162
26546452-7	2015	We demonstrate that 9A11, as well as two other cytoplasmic domain-specific mAbs, E1L3N and SP142, can clearly delineate the membrane of PD-L1-positive cells in formalin-fixed paraffin-embedded tissue and facilitate interpretation of staining results.	Formaldehyde	160-168	CD274 molecule	Homo sapiens	136-141
26384642-5	2015	Using DNA from both tumor and formalin-fixed paraffin-embedded tissues, we demonstrated a high efficiency of TaqMan probes in mono- and multiplex mutation scanning of KRAS, NRAS (codons 12, 13, and 61), and BRAF (codon 600) genes.	Formaldehyde	30-38	KRAS proto-oncogene, GTPase	Homo sapiens	167-171
26384642-5	2015	Using DNA from both tumor and formalin-fixed paraffin-embedded tissues, we demonstrated a high efficiency of TaqMan probes in mono- and multiplex mutation scanning of KRAS, NRAS (codons 12, 13, and 61), and BRAF (codon 600) genes.	Formaldehyde	30-38	NRAS proto-oncogene, GTPase	Homo sapiens	173-177
26673410-2	2015	The aim of this study was to develop an immunohistochemistry (IHC) assay to assess GR expression in archival formalin-fixed, paraffin-embedded human invasive breast carcinoma samples.	Formaldehyde	109-117	nuclear receptor subfamily 3 group C member 1	Homo sapiens	83-85
26496966-3	2015	Here, we present novel Fe3O4@DAPF core-shell ferromagnetic nanorods (CSFMNRs) for the removal of Pb(II) from aqueous solutions; they were prepared by the facile surface modification of twin-like ferromagnetic Fe3O4 nanorods using a 2,3-diaminophenol and formaldehyde (DAPF)-based polymer.	Formaldehyde	254-266	submaxillary gland androgen regulated protein 3B	Homo sapiens	97-103
26728267-4	2015	We investigated the effects of formaldehyde on oxidative stress, mitochondrial respiratory functions, and apoptosis on the sensitive neuronal SK-N-SH cells.	Formaldehyde	31-43	hedgehog acyltransferase	Homo sapiens	142-146
26728267-9	2015	Furthermore, formaldehyde caused a concentration-dependent increase in nuclear fragmentation and in the activities of the apoptosis-initiator caspase-9 and apoptosis-effector caspase-3/-7, indicating apoptosis progression.	Formaldehyde	13-25	caspase 9	Homo sapiens	142-151
26728267-9	2015	Furthermore, formaldehyde caused a concentration-dependent increase in nuclear fragmentation and in the activities of the apoptosis-initiator caspase-9 and apoptosis-effector caspase-3/-7, indicating apoptosis progression.	Formaldehyde	13-25	caspase 3	Homo sapiens	175-187
26407762-0	2015	Multi-center evaluation of the novel fully-automated PCR-based Idylla  BRAF Mutation Test on formalin-fixed paraffin-embedded tissue of malignant melanoma.	Formaldehyde	93-101	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	71-75
26590113-9	2015	Formalin-injected paws of mice treated with EOCO revealed the down-regulated expression of tumor necrosis factor-alpha, interleukin-1beta, inducible nitric oxide synthase, and cyclooxygenase-2, as compared with those of control mice.	Formaldehyde	0-8	tumor necrosis factor	Mus musculus	91-118
26590113-9	2015	Formalin-injected paws of mice treated with EOCO revealed the down-regulated expression of tumor necrosis factor-alpha, interleukin-1beta, inducible nitric oxide synthase, and cyclooxygenase-2, as compared with those of control mice.	Formaldehyde	0-8	interleukin 1 beta	Mus musculus	120-137
26590113-9	2015	Formalin-injected paws of mice treated with EOCO revealed the down-regulated expression of tumor necrosis factor-alpha, interleukin-1beta, inducible nitric oxide synthase, and cyclooxygenase-2, as compared with those of control mice.	Formaldehyde	0-8	prostaglandin-endoperoxide synthase 2	Mus musculus	176-192
26770238-3	2015	METHODS: The expression of miR-370 was determined with quantitative real-time polymerase chain reaction in 60 formalin-fixed, paraffin-embedded primary breast cancer tissues.	Formaldehyde	110-118	microRNA 370	Homo sapiens	27-34
26297962-4	2015	Members of the miR-17 family were evaluated for expression in a vulvar tumor cell line (SW954) and 20 HPV negative formalin-fixed paraffin-embedded (FFPE) samples by quantitative real-time PCR (qRT-PCR).	Formaldehyde	115-123	microRNA 17	Homo sapiens	15-21
26400403-8	2015	Concomitantly, p-ERK 1/2 expression was upregulated in the ACC at 1 and 24 h post-formalin injection.	Formaldehyde	82-90	Eph receptor B1	Rattus norvegicus	17-20
26400403-9	2015	While all three general anesthetics effectively blocked nociceptive responses and activation of ERK in the rat ACC following formalin injection during anesthesia, only sevoflurane inhibited ERK activation in the spinal cord and ACC at 24 h post-injection.	Formaldehyde	125-133	Eph receptor B1	Rattus norvegicus	96-99
26001593-6	2015	As a proof of the concept, we present the case of a metastatic patient with a PIK3CA wild-type primary tumor in which the PIK3CA E545K mutation was identified in both the circulating-free DNA obtained from a peripheral blood sample and in the formalin-fixed, paraffin-embedded liver metastasis.	Formaldehyde	243-251	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	78-84
26001593-6	2015	As a proof of the concept, we present the case of a metastatic patient with a PIK3CA wild-type primary tumor in which the PIK3CA E545K mutation was identified in both the circulating-free DNA obtained from a peripheral blood sample and in the formalin-fixed, paraffin-embedded liver metastasis.	Formaldehyde	243-251	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	122-128
26702420-7	2015	[1], it was used for multiplex scanning PIK3CA hotspot mutations in formalin-fixed paraffin-embedded (FFPE) samples from patients with colorectal and lung cancer.	Formaldehyde	68-76	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	40-46
26459371-3	2015	MATERIALS AND METHODS: We have analysed the immunohistochemical expression of Twist1 and Snai2, two of the most important transcription factors involved in epithelial to mesenchymal transition, in formalin-fixed paraffin-embedded samples of 23 spontaneous abortive pregnancies, 22 molar pregnancies (10 partial and 12 complete) and 7 term placentas.	Formaldehyde	197-205	twist family bHLH transcription factor 1	Homo sapiens	78-84
26218299-0	2015	Clinical and pathological features of Burkitt lymphoma showing expression of BCL2--an analysis including gene expression in formalin-fixed paraffin-embedded tissue.	Formaldehyde	124-132	BCL2 apoptosis regulator	Homo sapiens	77-81
26807012-3	2015	We found that only the short succinimidyl-diazirine cross-linker or formaldehyde captured the interaction between recombinant Rim1 and Pif1.	Formaldehyde	68-80	Rim1p	Saccharomyces cerevisiae S288C	126-130
26807012-3	2015	We found that only the short succinimidyl-diazirine cross-linker or formaldehyde captured the interaction between recombinant Rim1 and Pif1.	Formaldehyde	68-80	DNA helicase PIF1	Saccharomyces cerevisiae S288C	135-139
26335634-6	2015	Here we used formaldehyde-assisted isolation of regulatory elements to determine the role of Zelda in regulating regions of open chromatin in the early embryo.	Formaldehyde	13-25	zelda	Drosophila melanogaster	93-98
26357686-12	2015	Intrathecally administered amiloride synergistically interacts with tizanidine to reduce the nociceptive response in the formalin test, most likely by activating alpha2-adrenoceptors in the spinal cord.	Formaldehyde	121-129	adrenoceptor alpha 2A	Rattus norvegicus	162-182
26459371-3	2015	MATERIALS AND METHODS: We have analysed the immunohistochemical expression of Twist1 and Snai2, two of the most important transcription factors involved in epithelial to mesenchymal transition, in formalin-fixed paraffin-embedded samples of 23 spontaneous abortive pregnancies, 22 molar pregnancies (10 partial and 12 complete) and 7 term placentas.	Formaldehyde	197-205	snail family transcriptional repressor 2	Homo sapiens	89-94
26254729-7	2015	Intra-LC microinjection of orexin-A decreased the nociception score during both phases of formalin test.	Formaldehyde	90-98	hypocretin neuropeptide precursor	Rattus norvegicus	27-35
26512901-0	2015	Gabapentin Effects on PKC-ERK1/2 Signaling in the Spinal Cord of Rats with Formalin-Induced Visceral Inflammatory Pain.	Formaldehyde	75-83	protein kinase C, gamma	Rattus norvegicus	22-25
26512901-0	2015	Gabapentin Effects on PKC-ERK1/2 Signaling in the Spinal Cord of Rats with Formalin-Induced Visceral Inflammatory Pain.	Formaldehyde	75-83	mitogen activated protein kinase 3	Rattus norvegicus	26-32
26512901-10	2015	Western blot analysis also revealed that PKC membrane translocation and ERK1/2 phosphorylation increased significantly following formalin injection, confirming the recruitment of PKC and ERK1/2 during visceral inflammatory pain.	Formaldehyde	129-137	protein kinase C, gamma	Rattus norvegicus	41-44
26512901-10	2015	Western blot analysis also revealed that PKC membrane translocation and ERK1/2 phosphorylation increased significantly following formalin injection, confirming the recruitment of PKC and ERK1/2 during visceral inflammatory pain.	Formaldehyde	129-137	mitogen activated protein kinase 3	Rattus norvegicus	72-78
26512901-10	2015	Western blot analysis also revealed that PKC membrane translocation and ERK1/2 phosphorylation increased significantly following formalin injection, confirming the recruitment of PKC and ERK1/2 during visceral inflammatory pain.	Formaldehyde	129-137	protein kinase C, gamma	Rattus norvegicus	179-182
26512901-10	2015	Western blot analysis also revealed that PKC membrane translocation and ERK1/2 phosphorylation increased significantly following formalin injection, confirming the recruitment of PKC and ERK1/2 during visceral inflammatory pain.	Formaldehyde	129-137	mitogen activated protein kinase 3	Rattus norvegicus	187-193
26254729-8	2015	Furthermore, intra-LC microinjection of either SB-334867 (OX1 receptor antagonist) or AM251 (CB1 receptor antagonist) increased flinches and also the nociception score during phase 1, 2 and the inter-phase of formalin test.	Formaldehyde	209-217	cannabinoid receptor 1	Rattus norvegicus	93-96
26254729-10	2015	This data show that, activation of OX1 receptors in the LC can induce analgesia and also the blockade of OX1 or CB1 receptors is associated with hyperalgesia during formalin test.	Formaldehyde	165-173	cannabinoid receptor 1	Rattus norvegicus	112-115
26162699-6	2015	At this dose, the effects of UCM765 and UCM924 were similar to those produced by 200 mg/kg acetaminophen in the hot-plate test, and by 3 mg/kg ketorolac or 150 mg/kg MLT in the formalin test.	Formaldehyde	177-185	mitogen-activated protein kinase kinase kinase 20	Homo sapiens	166-169
26472811-6	2015	In contrast, the gas phase acted like a sheer TRPA1 agonist, consistent with its composition, among other compounds, of volatile reactive carbonyls like formaldehyde and acrolein.	Formaldehyde	153-165	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	46-51
26484710-0	2015	Employing Digital Droplet PCR to Detect BRAF V600E Mutations in Formalin-fixed Paraffin-embedded Reference Standard Cell Lines.	Formaldehyde	64-72	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	40-44
26318332-5	2015	Furthermore, the intrathecal injection of EphB2-Fc, an EphB receptor blocker, suppressed formalin-induced inflammatory, chronic constriction injury (CCI)-induced neuropathic, and tibia bone cavity tumor cell implantation (TCI)-induced bone cancer pain behaviors, in addition to reducing the activation of spinal PKCgamma.	Formaldehyde	89-97	Eph receptor B2	Mus musculus	42-47
26417104-8	2015	Analysis of global formaldehyde-cross-linking studies indicated that the Igh locus superanchor interacts with the VH region repertoire across vast genomic distances.	Formaldehyde	19-31	immunoglobulin heavy locus	Homo sapiens	73-76
26722540-3	2015	FRZB expression was evaluated by immunohistochemistry in formalin-fixed paraffin embedded (FFPE) HCC and paired bone metastasis tissues from 13 patients that underwent surgical resection.	Formaldehyde	57-65	frizzled related protein	Homo sapiens	0-4
26722420-4	2015	Here, we measured expression levels of TS, TP, and DPD in formalin-fixed, paraffin-embedded, CRC specimens and paracancerous tissue with normal mucosa by immunohistochemical and fluorescence real-time quantitative polymerase chain reaction techniques.	Formaldehyde	58-66	dihydropyrimidine dehydrogenase	Homo sapiens	51-54
26117383-11	2015	We conclude that MDR3 immunostaining on formalin-fixed and paraffin-embedded sections is a useful tool to diagnose severe MDR3 deficiency in pediatric liver cholestatic disease cases where genetic testing is not available.	Formaldehyde	40-48	ATP binding cassette subfamily B member 4	Homo sapiens	17-21
26149442-0	2015	Quantification of HER2 by Targeted Mass Spectrometry in Formalin-Fixed Paraffin-Embedded (FFPE) Breast Cancer Tissues.	Formaldehyde	56-64	erb-b2 receptor tyrosine kinase 2	Homo sapiens	18-22
25782913-7	2015	Behavior tests showed that intrathecally applied FGF7 potentiated the formalin-induced acute nociceptive response.	Formaldehyde	70-78	fibroblast growth factor 7	Mus musculus	49-53
26149442-2	2015	We have developed and evaluated a selectedreaction monitoring assay for the human receptor tyrosine-protein kinase erbB-2 (HER2) in formalin-fixed paraffin-embedded breast tumors.	Formaldehyde	132-140	erb-b2 receptor tyrosine kinase 2	Homo sapiens	82-121
26149442-2	2015	We have developed and evaluated a selectedreaction monitoring assay for the human receptor tyrosine-protein kinase erbB-2 (HER2) in formalin-fixed paraffin-embedded breast tumors.	Formaldehyde	132-140	erb-b2 receptor tyrosine kinase 2	Homo sapiens	123-127
26149442-6	2015	The six HER2 peptides were quantified by selected reaction monitoring in a cohort of 40 archival formalin-fixed paraffin-embedded tumor tissues from women with invasive breast carcinomas, which showed different levels of HER2 gene amplification as assessed by standard methods used in clinical pathology.	Formaldehyde	97-105	erb-b2 receptor tyrosine kinase 2	Homo sapiens	8-12
26149442-7	2015	The amounts of the six HER2 peptides were highly and significantly correlated with each other, indicating that peptide levels can be used as surrogates of protein amounts in formalin-fixed paraffin-embedded tissues.	Formaldehyde	174-182	erb-b2 receptor tyrosine kinase 2	Homo sapiens	23-27
26412304-3	2015	Here we show that endogenous formaldehyde is removed by the enzyme alcohol dehydrogenase 5 (ADH5/GSNOR), and Adh5(-/-) mice therefore accumulate formaldehyde adducts in DNA.	Formaldehyde	29-41	alcohol dehydrogenase 5 (class III), chi polypeptide	Mus musculus	92-96
26412304-3	2015	Here we show that endogenous formaldehyde is removed by the enzyme alcohol dehydrogenase 5 (ADH5/GSNOR), and Adh5(-/-) mice therefore accumulate formaldehyde adducts in DNA.	Formaldehyde	29-41	alcohol dehydrogenase 5 (class III), chi polypeptide	Mus musculus	97-102
26412304-3	2015	Here we show that endogenous formaldehyde is removed by the enzyme alcohol dehydrogenase 5 (ADH5/GSNOR), and Adh5(-/-) mice therefore accumulate formaldehyde adducts in DNA.	Formaldehyde	29-41	alcohol dehydrogenase 5 (class III), chi polypeptide	Mus musculus	109-113
26412304-3	2015	Here we show that endogenous formaldehyde is removed by the enzyme alcohol dehydrogenase 5 (ADH5/GSNOR), and Adh5(-/-) mice therefore accumulate formaldehyde adducts in DNA.	Formaldehyde	145-157	alcohol dehydrogenase 5 (class III), chi polypeptide	Mus musculus	92-96
26412304-3	2015	Here we show that endogenous formaldehyde is removed by the enzyme alcohol dehydrogenase 5 (ADH5/GSNOR), and Adh5(-/-) mice therefore accumulate formaldehyde adducts in DNA.	Formaldehyde	145-157	alcohol dehydrogenase 5 (class III), chi polypeptide	Mus musculus	97-102
26412304-3	2015	Here we show that endogenous formaldehyde is removed by the enzyme alcohol dehydrogenase 5 (ADH5/GSNOR), and Adh5(-/-) mice therefore accumulate formaldehyde adducts in DNA.	Formaldehyde	145-157	alcohol dehydrogenase 5 (class III), chi polypeptide	Mus musculus	109-113
26813592-8	2015	Comparative experiments: (1) Comparison of the results of 4% neutral buffered formalin fixed for different time (24 h, 48 h, 72 h) on the Ventana IHC ALK (D5F3) staining was conducted in two cases of IHC ALK positive FFPE cell blocks; (2) Comparing qRT-PCR results for ALK fusion in samples from FFPE cell blocks and cytospin prepared slides in 10 cases of lung adenocarcinoma cytologic specimens.	Formaldehyde	78-86	ALK receptor tyrosine kinase	Homo sapiens	150-153
26067582-8	2015	Our in vivo experiments showed that mmu-miR-667-3p is strongly correlated with decreasing amounts of Comt mRNA in the brain, and lentiviral injections of mmu-miR-3470a, mmu-miR-3470b, and mmu-miR-667 increase hypersensitivity in the mouse formalin model, consistent with reduced COMT activity.	Formaldehyde	239-247	microRNA 667	Mus musculus	36-47
26813592-17	2015	For two ALK IHC positive cases, which were 4% neutral buffered formalin fixed for 72 h, the result of Ventana IHC ALK (D5F3) staining became weakened obviously and uneven.	Formaldehyde	63-71	ALK receptor tyrosine kinase	Homo sapiens	8-11
26813592-17	2015	For two ALK IHC positive cases, which were 4% neutral buffered formalin fixed for 72 h, the result of Ventana IHC ALK (D5F3) staining became weakened obviously and uneven.	Formaldehyde	63-71	ALK receptor tyrosine kinase	Homo sapiens	114-117
26335936-3	2015	METHODS: Ten formalin fixed paraffin embedded specimens including KRAS/NRAS (exons 2, 3, 4) and BRAF (codon 600) mutations were validated by three referral laboratories and sent to 88 participant centers.	Formaldehyde	13-21	KRAS proto-oncogene, GTPase	Homo sapiens	66-70
26311741-3	2015	SPHK1 expression was examined in 287 formalin-fixed, paraffin-embedded cervical cancer tissues using immunohistochemistry, and its clinical implications and prognostic significance were analyzed.	Formaldehyde	37-45	sphingosine kinase 1	Homo sapiens	0-5
26330075-3	2015	We used Idylla to detect BRAF V600 mutations in archived formalin-fixed paraffin-embedded (FFPE) tumor samples and compared these results with those obtained using the cobas 4800 BRAF V600 Mutation Test or MiSeq deep sequencing system and with those obtained by a Clinical Laboratory Improvement Amendments (CLIA)-certified laboratory employing polymerase chain reaction-based sequencing, mass spectrometric detection, or next-generation sequencing.	Formaldehyde	57-65	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	25-29
25907264-6	2015	We demonstrate histopathological findings and confirm the HEY1-NCOA2 gene fusion in a formalin-fixed paraffin-embedded archival sample using simple reverse transcription polymerase chain reaction (RT-PCR) method.	Formaldehyde	86-94	hes related family bHLH transcription factor with YRPW motif 1	Homo sapiens	58-62
26317305-3	2015	We report an automated PD-L1 immunohistochemistry (IHC) assay, which was developed to detect cell surface PD-L1 in formalin-fixed paraffin-embedded human tumor tissue specimens using Dako"s Autostainer Link 48.	Formaldehyde	115-123	CD274 molecule	Homo sapiens	23-28
26317305-3	2015	We report an automated PD-L1 immunohistochemistry (IHC) assay, which was developed to detect cell surface PD-L1 in formalin-fixed paraffin-embedded human tumor tissue specimens using Dako"s Autostainer Link 48.	Formaldehyde	115-123	CD274 molecule	Homo sapiens	106-111
25911044-7	2015	Computational results are in a good agreement with experimental data on hydrolysis of RDX, suggesting that 4-nitro-2,4-diazabutanal, nitrite, formaldehyde, and nitrous oxide are main products for early stages of RDX decomposition under alkaline conditions.	Formaldehyde	142-154	radixin	Homo sapiens	86-89
26037795-3	2015	METHODS: PD-L1 expression (cutoff 5%) was analyzed by immunohistochemistry with two different antibodies in BRAF(V600)-mutated formalin-fixed and paraffin-embedded samples from 80 consecutive MMP treated with BRAFi at a single institution.	Formaldehyde	127-135	CD274 molecule	Homo sapiens	9-14
26037795-3	2015	METHODS: PD-L1 expression (cutoff 5%) was analyzed by immunohistochemistry with two different antibodies in BRAF(V600)-mutated formalin-fixed and paraffin-embedded samples from 80 consecutive MMP treated with BRAFi at a single institution.	Formaldehyde	127-135	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	108-117
26314785-2	2015	Here, we showed that both TRPV1 and TRPV4 might contribute to biphasic nocifensive behavior and neuroendocrine response following a formalin test.	Formaldehyde	132-140	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	26-31
26314785-2	2015	Here, we showed that both TRPV1 and TRPV4 might contribute to biphasic nocifensive behavior and neuroendocrine response following a formalin test.	Formaldehyde	132-140	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	36-41
26314785-4	2015	Subcutaneous (s.c.) injection of formalin caused less nocifensive behavior in Trpv1(-/-) and Trpv4(-/-) mice than in WT mice during phase I.	Formaldehyde	33-41	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	78-83
26314785-4	2015	Subcutaneous (s.c.) injection of formalin caused less nocifensive behavior in Trpv1(-/-) and Trpv4(-/-) mice than in WT mice during phase I.	Formaldehyde	33-41	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	93-98
26314785-5	2015	In phase II, however, formalin induced less nocifensive behavior only in the Trpv1(-/-) mice, but not in the Trpv4(-/-) mice, relative to WT mice.	Formaldehyde	22-30	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	77-82
26314785-6	2015	The number of Fos-like immunoreactive (LI) neurons in laminae I-II of the dorsal horn increased in all types of mice 90 min after s.c. injection of formalin; however, there was no difference in the other regions between saline- and formalin-treated mice.	Formaldehyde	148-156	FBJ osteosarcoma oncogene	Mus musculus	14-17
26314785-8	2015	These results suggest that TRPV4-mediated nociceptive information from the peripheral tissue excluding the spinal pathway might be involved the formalin behavioral response during phase I.	Formaldehyde	144-152	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	27-32
26314785-9	2015	Only TRPV1 might regulate the formalin behavioral response in peripheral neuron.	Formaldehyde	30-38	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	5-10
25907264-6	2015	We demonstrate histopathological findings and confirm the HEY1-NCOA2 gene fusion in a formalin-fixed paraffin-embedded archival sample using simple reverse transcription polymerase chain reaction (RT-PCR) method.	Formaldehyde	86-94	nuclear receptor coactivator 2	Homo sapiens	63-68
26716343-1	2015	The aims of this study are immobilization of formaldehyde dehydrogenase (FDH) into nano-space of nanostructured carbon and evaluation as a possible sensor detecting low concentration formaldehyde.	Formaldehyde	45-57	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	73-76
26240788-5	2015	Two new formalin-fixed, paraffin-embedded (FFPE) tissue-compatible diagnostic immunohistochemical markers were identified for two of the three subtypes: LMOD1 for subtype I LMS and ARL4C for subtype II LMS.	Formaldehyde	8-16	leiomodin 1	Homo sapiens	153-158
26240788-5	2015	Two new formalin-fixed, paraffin-embedded (FFPE) tissue-compatible diagnostic immunohistochemical markers were identified for two of the three subtypes: LMOD1 for subtype I LMS and ARL4C for subtype II LMS.	Formaldehyde	8-16	ADP ribosylation factor like GTPase 4C	Homo sapiens	181-186
26283398-7	2015	L1 proteins must be expressed for retrotransposition to occur; therefore, we evaluated the expression of open reading frame 1 protein (ORF1p), a protein encoded by L1, in eight of the EAC cases for which formalin-fixed paraffin embedded tissue was available.	Formaldehyde	204-212	ORF1	Homo sapiens	135-140
25990136-3	2015	Since it is located in cell nucleus and acts as a histone methylation eraser, LSD1 specifically removes mono- or dimethylated histone H3 lysine 4 (H3K4) and H3 lysine 9 (H3K9) through formaldehyde-generating oxidation.	Formaldehyde	184-196	lysine demethylase 1A	Homo sapiens	78-82
26268359-4	2015	We tested KIF5B-RET translocation in Formalin Fixed Paraffin Embedded using fluorescence in situ hybridization.	Formaldehyde	37-45	kinesin family member 5B	Homo sapiens	10-15
25946975-7	2015	A positive correlation was observed between SIRT1 and TAp63 expression in HNSCC tissues, as determined by quantitative reverse transcription-polymerase chain reaction analysis of RNA extracted from formalin-fixed paraffin-embedded biopsy samples.	Formaldehyde	198-206	sirtuin 1	Homo sapiens	44-49
26208080-6	2015	Alcohol dehydrogenase (EC 1.1.1.1), able to catalyze the conversion of formaldehyde into methanol, was selected as the model enzyme.	Formaldehyde	71-83	aldo-keto reductase family 1 member A1	Homo sapiens	0-21
26272725-0	2015	Short-term anesthesia inhibits formalin-induced extracellular signal-regulated kinase (ERK) activation in the rostral anterior cingulate cortex but not in the spinal cord.	Formaldehyde	31-39	mitogen-activated protein kinase 1	Homo sapiens	48-85
26268359-4	2015	We tested KIF5B-RET translocation in Formalin Fixed Paraffin Embedded using fluorescence in situ hybridization.	Formaldehyde	37-45	ret proto-oncogene	Homo sapiens	16-19
26272725-0	2015	Short-term anesthesia inhibits formalin-induced extracellular signal-regulated kinase (ERK) activation in the rostral anterior cingulate cortex but not in the spinal cord.	Formaldehyde	31-39	mitogen-activated protein kinase 1	Homo sapiens	87-90
26283908-7	2015	In the formalin model of acute peripheral inflammatory pain, Sphk2(-/-) mice showed facilitation of nociceptive transmission during the late response, whereas responses to early acute pain, and the number of c-Fos immunoreactive dorsal horn neurons were not different between Sphk2(-/-) and wild-type mice.	Formaldehyde	7-15	sphingosine kinase 2	Mus musculus	61-66
25917404-7	2015	It is apparent from immonohistology data that both benign and cancerous (primary and metastasis) formalin fixed paraffin embedded (FFPE) tissue samples exhibit CLU expression.	Formaldehyde	97-105	clusterin	Homo sapiens	160-163
25896974-9	2015	We identified two new formalin-fixed, paraffin-embedded tissue-compatible diagnostic immunohistochemical markers; LMOD1 for subtype I leiomyosarcoma and ARL4C for subtype II leiomyosarcoma.	Formaldehyde	22-30	leiomodin 1	Homo sapiens	114-119
25896974-9	2015	We identified two new formalin-fixed, paraffin-embedded tissue-compatible diagnostic immunohistochemical markers; LMOD1 for subtype I leiomyosarcoma and ARL4C for subtype II leiomyosarcoma.	Formaldehyde	22-30	ADP ribosylation factor like GTPase 4C	Homo sapiens	153-158
26421170-7	2015	PATIENTS AND METHODS: In this cross sectional retrospective study immunohistochemistry analyses of formalin-fixed paraffin-embedded (FFPE) tumor tissues were performed to characterize the expression of nuclear beta-catenin in a series of 165 Iranian patients with colorectal carcinoma.	Formaldehyde	99-107	catenin beta 1	Homo sapiens	210-222
26157038-3	2015	For example, CD4 and CD8 have been difficult to detect using IHC on formalin-fixed and paraffin-embedded mouse tissue, prompting alternative methods.	Formaldehyde	68-76	CD4 antigen	Mus musculus	13-16
26109910-3	2015	METHODS: MiR-203 expression in 95 formalin-fixed, paraffin embedded (FFPE) HCC tissues and their paired adjacent non-cancerous tissues was evaluated by quantitative reverse transcription polymerase chain reaction (qRT-PCR).	Formaldehyde	34-42	microRNA 203a	Homo sapiens	9-16
26186596-8	2015	In addition, formaldehyde exposure triggered human trophoblast fusion by upregulating syncitin-1 receptor expression (ASC-type amino-acid transporter 2: ASCT2).	Formaldehyde	13-25	solute carrier family 1 member 5	Homo sapiens	153-158
26186596-9	2015	Moreover, we show that formaldehyde-exposed trophoblasts present an altered redox status associated with oxidative stress, and an increase in ASCT2 expression intended to compensate for this stress.	Formaldehyde	23-35	solute carrier family 1 member 5	Homo sapiens	142-147
26186596-10	2015	Finally, we demonstrate that the adverse effects of formaldehyde on trophoblast differentiation and fusion are reversed by N-acetyl-L-cysteine (Nac), an antioxidant.	Formaldehyde	52-64	X-linked Kx blood group	Homo sapiens	144-147
25990725-6	2015	To investigate the effect of GRWD1 on chromatin architecture, we used formaldehyde-assisted isolation of regulatory elements (FAIRE)-seq or FAIRE-quantitative PCR analyses, and the results suggest that GRWD1 regulates chromatin openness at specific chromatin locations.	Formaldehyde	70-82	glutamate rich WD repeat containing 1	Homo sapiens	202-207
26416063-3	2015	The purpose of the current study was to detect the expression of MRGD mRNA in NSCLC formalin-fixed (FF), paraffin-embedded (PE) tissues and to investigate the clinicopathological significance of the MRGD level in NSCLC patients.	Formaldehyde	84-92	MAS related GPR family member D	Homo sapiens	65-69
25827135-2	2015	METHODS AND RESULTS: Immunohistochemical staining for PAX8 was performed on formalin fixed, paraffin embedded tissues from 47 POMTs, 18 eMOMCs and 70 extragenital primary mucinous carcinomas (ePMCs) using anti-PAX8 rabbit polyclonal antibody (pAb) and anti-PAX8 rabbit monoclonal antibody (mAb).	Formaldehyde	76-84	paired box 8	Homo sapiens	54-58
26379923-0	2015	Over-expression of miR-675 in formalin-fixed paraffin-embedded (FFPE) tissues of breast cancer patients.	Formaldehyde	30-38	microRNA 675	Homo sapiens	19-26
26379923-12	2015	CONCLUSIONS: Taken together, our study demonstrated that miR-675 in formalin-fixed paraffin-embedded (FFPE) tissues might serve as a good source for biomarker discovery and breast cancer validation.	Formaldehyde	68-76	microRNA 675	Homo sapiens	57-64
25545408-5	2015	METHODS: Immunohistochemistry was used to investigate expression of WRN in formalin-fixed, paraffin wax-embedded tissue specimens of 9 squamous cell carcinoma (SCC), 15 actinic keratosis (AK), 11 Bowen disease (BD) and 11 normal-appearing peripheral tissue samples, obtained from patients during surgical resections.	Formaldehyde	75-83	WRN RecQ like helicase	Homo sapiens	68-71
25953218-5	2015	Moreover, microRNA-21 expression was quantified in formalin-fixed paraffin-embedded biopsies from this cohort, and the results obtained were correlated with clinical and molecular characteristics, pathological response, and outcome.	Formaldehyde	51-59	microRNA 21	Homo sapiens	10-21
25663493-4	2015	Protein expression levels of PTPN12 were explored by semiquantitative immunohistochemical staining on archival formalin-fixed, paraffin-embedded pathological specimens consisting of 203 NPCs, and 40 normal nasopharyngeal mucosa tissues.	Formaldehyde	111-119	protein tyrosine phosphatase non-receptor type 12	Homo sapiens	29-35
26081767-1	2015	BACKGROUND: The purpose of this study was to develop a cost-effective approach for the determination of EGFR and KRAS mutations in formalin-fixed paraffin-embedded (FFPE) non-small cell lung cancer (NSCLC) and colorectal cancer (CRC) samples from Chinese patients based on a sensitive pyrosequencing (PS) technique.	Formaldehyde	131-139	epidermal growth factor receptor	Homo sapiens	104-108
26081767-1	2015	BACKGROUND: The purpose of this study was to develop a cost-effective approach for the determination of EGFR and KRAS mutations in formalin-fixed paraffin-embedded (FFPE) non-small cell lung cancer (NSCLC) and colorectal cancer (CRC) samples from Chinese patients based on a sensitive pyrosequencing (PS) technique.	Formaldehyde	131-139	KRAS proto-oncogene, GTPase	Homo sapiens	113-117
26086362-3	2015	METHODS: A quantitative multiplex, methylation-specific PCR assay was developed to assess promoter methylation of the APC, CCND2, GSTP1, PTGS2 and RARB genes in formalin-fixed, paraffin-embedded tissue samples from 42 patients with benign prostatic hyperplasia and radical prostatectomy specimens of patients with high-risk PCa, encompassing training and validation cohorts of 147 and 71 patients, respectively.	Formaldehyde	161-169	retinoic acid receptor beta	Homo sapiens	147-151
26066800-4	2015	A new monoclonal antibody, FER216, was generated to investigate CSF1R protein distribution in formalin fixed tissue samples from 24 reactive lymphoid tissues and 187 different lymphoma types.	Formaldehyde	94-102	colony stimulating factor 1 receptor	Homo sapiens	64-69
26046358-8	2015	Further, we also applied our quantitation method, using these endogenous controls, to evaluate the expression of three previously identified miRNA biomarkers, miR-1, miR-208b, and miR-499a, in formalin-fixed tissues from AMI patients.	Formaldehyde	193-201	fibronectin type III and SPRY domain containing 1	Homo sapiens	159-164
26046358-8	2015	Further, we also applied our quantitation method, using these endogenous controls, to evaluate the expression of three previously identified miRNA biomarkers, miR-1, miR-208b, and miR-499a, in formalin-fixed tissues from AMI patients.	Formaldehyde	193-201	microRNA 208b	Homo sapiens	166-174
26046358-8	2015	Further, we also applied our quantitation method, using these endogenous controls, to evaluate the expression of three previously identified miRNA biomarkers, miR-1, miR-208b, and miR-499a, in formalin-fixed tissues from AMI patients.	Formaldehyde	193-201	microRNA 499a	Homo sapiens	180-188
25792480-10	2015	Upon the light exposure, CdS likely photocatalyzes the reduction of carbonate ions to formates/formaldehydes.	Formaldehyde	95-108	CDP-diacylglycerol synthase 1	Homo sapiens	25-28
26065412-6	2015	RESULTS: We found that JNK inhibition by SP600125 (3 mg/kg) produces a greater antinociceptive effect than morphine (6 mg/kg) alone in the formalin test.	Formaldehyde	139-147	mitogen-activated protein kinase 8	Homo sapiens	23-26
26067287-0	2015	Inhibition of Spinal Interlukin-33/ST2 Signaling and Downstream ERK and JNK Pathways in Electroacupuncture Analgesia in Formalin Mice.	Formaldehyde	120-128	mitogen-activated protein kinase 8	Mus musculus	72-75
26067287-4	2015	These data suggest that EA alleviates formalin-induced inflammatory pain, at least partially, by inhibiting of spinal IL-33/ST2 signaling and the downstream ERK and JNK pathways.	Formaldehyde	38-46	interleukin 33	Mus musculus	118-123
26067287-4	2015	These data suggest that EA alleviates formalin-induced inflammatory pain, at least partially, by inhibiting of spinal IL-33/ST2 signaling and the downstream ERK and JNK pathways.	Formaldehyde	38-46	interleukin 1 receptor-like 1	Mus musculus	124-127
26067287-4	2015	These data suggest that EA alleviates formalin-induced inflammatory pain, at least partially, by inhibiting of spinal IL-33/ST2 signaling and the downstream ERK and JNK pathways.	Formaldehyde	38-46	mitogen-activated protein kinase 1	Mus musculus	157-160
26067287-4	2015	These data suggest that EA alleviates formalin-induced inflammatory pain, at least partially, by inhibiting of spinal IL-33/ST2 signaling and the downstream ERK and JNK pathways.	Formaldehyde	38-46	mitogen-activated protein kinase 8	Mus musculus	165-168
26255449-5	2015	MATERIAL AND METHODS: Caveolin-1 expression was studied in a total of 82 formalin-fixed, paraffin-embedded specimens of ovarian serous tumors and its association with different clinicopathologic parameters was evaluated.	Formaldehyde	73-81	caveolin 1	Homo sapiens	22-32
25777368-2	2015	ADH3 is a highly conserved bifunctional enzyme involved in formaldehyde detoxification and termination of nitric oxide signaling.	Formaldehyde	59-71	alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide	Mus musculus	0-4
25777368-3	2015	Formaldehyde and nitric oxide are nonenzymatically conjugated with glutathione, which is regenerated after ADH3 metabolizes the conjugates.	Formaldehyde	0-12	alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide	Mus musculus	107-111
25524664-4	2015	OBJECTIVES: Motivated by these diagnostic quandaries, we have analyzed a large series of archived formalin-fixed paraffin-embedded (FFPE) specimens of atypical CD8+ cutaneous infiltrates with clear-cut diagnosis and clinical follow-up (n = 44) including five cases of indolent CD8+ lymphoid proliferation by using immunohistochemistry with the aim of obtaining markers predictive of subtype assignment.	Formaldehyde	98-106	CD8a molecule	Homo sapiens	160-163
25870121-3	2015	The expression of PAUF was immunohistochemically determined in 345 formalin-fixed, paraffin-embedded cervical cancer tissues and 107 normal cervical epitheliums.	Formaldehyde	67-75	zymogen granule protein 16B	Homo sapiens	18-22
25625587-4	2015	Confocal laser scanning microscopy and conventional immunohistochemical analysis were used to quantify FAP and VEGF expression levels in formalin-fixed and paraffin-embedded tissue biopsies from 46 patients (male, 26; female, 20; mean age, 66 years; age range, 53-80 years) with pancreatic adenocarcinoma stage IIA or IIB.	Formaldehyde	137-145	vascular endothelial growth factor A	Homo sapiens	111-115
26091472-7	2015	HRs results of TP slides and those of formalin-fixed paraffin-embedded (FFPE) slides were correlated well for ER (concordance rate =  3.3%, kappa value = 0.85) and PR (concordance rate = 88.6%, kappa value = 0.75).	Formaldehyde	38-46	progesterone receptor	Homo sapiens	164-166
26191231-4	2015	MATERIALS AND METHODS: Immunohistochemistry was used to assess the level of XB130 protein in surgically resected, formalin-fixed, paraffin-embedded breast cancer specimens.	Formaldehyde	114-122	actin filament associated protein 1 like 2	Homo sapiens	76-81
26175849-3	2015	MATERIALS AND METHODS: In this paper, we explored the expression of miR-29b in a cohort of 67 pairs of formalin-fixed paraffin-embedded specimens with detailed pathological and clinical characteristics, and further analyzed the effects of miR-29b on the malignant phenotype of HER-2-positive breast cancer cells and the relevant mechanisms involved.	Formaldehyde	103-111	microRNA 29b-1	Homo sapiens	68-75
25897674-2	2015	METHODS: We used droplet digital polymerase chain reaction (ddPCR) to evaluate HER2 amplification in formalin-fixed and paraffin-embedded (FFPE) samples and cell-free serum circulating tumour DNA (ctDNA) in 25 patients with gastric cancer.	Formaldehyde	101-109	erb-b2 receptor tyrosine kinase 2	Homo sapiens	79-83
25993328-4	2015	The aim of our study is to provide a recommendation and report on pitfalls in the use of phospho-specific antibodies against mTORC1-targets phospho-RPS6 (Ser235/236; Ser240/244) and phospho-4EBP1 (Thr37/46) in formalin fixed, paraffin embedded material.	Formaldehyde	210-218	CREB regulated transcription coactivator 1	Mus musculus	125-131
25848691-7	2015	Using a recently developed method for RNA-pulldown with formaldehyde cross-linking, we found that Lnc_bc060912 interacted with the two DNA damage repair proteins PARP1 and NPM1.	Formaldehyde	56-68	poly(ADP-ribose) polymerase 1	Homo sapiens	162-167
25848691-7	2015	Using a recently developed method for RNA-pulldown with formaldehyde cross-linking, we found that Lnc_bc060912 interacted with the two DNA damage repair proteins PARP1 and NPM1.	Formaldehyde	56-68	nucleophosmin 1	Homo sapiens	172-176
26150155-0	2015	Reliable LC3 and p62 autophagy marker detection in formalin fixed paraffin embedded human tissue by immunohistochemistry.	Formaldehyde	51-59	sequestosome 1	Homo sapiens	17-20
26150155-3	2015	Here we show the feasibility of specifically and reliably assessing the autophagy markers LC3B and p62 (SQSTM1) in formalin fixed and paraffin embedded human tissue by immunohistochemistry.	Formaldehyde	115-123	microtubule associated protein 1 light chain 3 beta	Homo sapiens	90-94
26150155-3	2015	Here we show the feasibility of specifically and reliably assessing the autophagy markers LC3B and p62 (SQSTM1) in formalin fixed and paraffin embedded human tissue by immunohistochemistry.	Formaldehyde	115-123	sequestosome 1	Homo sapiens	99-102
26150155-3	2015	Here we show the feasibility of specifically and reliably assessing the autophagy markers LC3B and p62 (SQSTM1) in formalin fixed and paraffin embedded human tissue by immunohistochemistry.	Formaldehyde	115-123	sequestosome 1	Homo sapiens	104-110
26150155-6	2015	LC3B and p62 antibodies were validated on formalin fixed and paraffin embedded cell pellets of treated and control cells and finally applied on a tissue microarray with 80 human malignant and non-neoplastic lung and stomach formalin fixed and paraffin embedded tissue samples.	Formaldehyde	42-50	microtubule associated protein 1 light chain 3 beta	Homo sapiens	0-4
26150155-11	2015	In summary, we present a specific and reliable IHC staining of LC3B and p62 on formalin fixed and paraffin embedded human tissue.	Formaldehyde	79-87	microtubule associated protein 1 light chain 3 beta	Homo sapiens	63-67
26150155-11	2015	In summary, we present a specific and reliable IHC staining of LC3B and p62 on formalin fixed and paraffin embedded human tissue.	Formaldehyde	79-87	sequestosome 1	Homo sapiens	72-75
25934889-3	2015	EXPERIMENTAL DESIGN: An ITK-specific monoclonal antibody was used to probe sections from deidentified, formalin-fixed paraffin-embedded tumor blocks or cell line arrays and ITK was visualized by IHC.	Formaldehyde	103-111	IL2 inducible T cell kinase	Mus musculus	24-27
25659223-2	2015	OBJECTIVE: We aimed to assess the diagnostic accuracy of an immunohistochemistry (IHC) approach using a novel anti-NRAS (Q61R) monoclonal antibody on formalin-fixed paraffin-embedded tissue samples from patients with metastatic melanoma.	Formaldehyde	150-158	NRAS proto-oncogene, GTPase	Homo sapiens	115-119
26604484-13	2015	The immunohistochemistry was carried out on neutral buffered formalin-fixed paraffin-embedded tissue sections by using the monoclonal antibody of HIF-1alpha.	Formaldehyde	61-69	hypoxia inducible factor 1 subunit alpha	Homo sapiens	146-156
25431176-3	2015	Formaldehyde-assisted isolation of regulatory elements (FAIRE) and chromatin immunoprecipitation (ChIP) followed by sequencing (FAIRE-seq and ChIP-seq) analyses indicated the cooperation of Smad2/3 with c-Fos during osteoclastogenesis.	Formaldehyde	0-12	SMAD family member 2	Homo sapiens	190-197
25431176-3	2015	Formaldehyde-assisted isolation of regulatory elements (FAIRE) and chromatin immunoprecipitation (ChIP) followed by sequencing (FAIRE-seq and ChIP-seq) analyses indicated the cooperation of Smad2/3 with c-Fos during osteoclastogenesis.	Formaldehyde	0-12	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	203-208
25761397-9	2015	RESULTS: The levels of MDA in sera were increased and the TAC, TP53, and Ass (1-40) levels were reduced in the formaldehyde-treated group with respect to the control group (p&lt;0.005).	Formaldehyde	111-123	tumor protein p53	Rattus norvegicus	63-67
25760407-1	2015	In this study, a facile method for synthesizing a novel graphene oxide/pyrrole-formaldehyde (GOP-1) composite hydrogel was developed via in situ polymerization of pyrrole and formaldehyde in the presence of graphene oxide sheets without any additional catalyst.	Formaldehyde	79-91	C-type lectin domain containing 16A	Homo sapiens	93-98
25651992-7	2015	After pathological diagnoses of NSCLC, EGFR mutation status in formalin-fixed, paraffin- embedded samples was confirmed by the PCR-invader method, and the concordance rates between the PCR methods were compared.	Formaldehyde	63-71	epidermal growth factor receptor	Homo sapiens	39-43
25876105-11	2015	CONCLUSION: Increased GLB1 is a valuable marker in formalin-fixed paraffin-embedded (FFPE) tissues for the senescence-like phenotype and associates with improved cancer outcomes.	Formaldehyde	51-59	galactosidase beta 1	Homo sapiens	22-26
25770783-0	2015	BLM protein mitigates formaldehyde-induced genomic instability.	Formaldehyde	22-34	BLM RecQ like helicase	Homo sapiens	0-3
25770783-4	2015	This study specifically examines the role of a genome stability protein, Bloom (BLM) in limiting formaldehyde-induced cellular and genetic abnormalities.	Formaldehyde	97-109	BLM RecQ like helicase	Homo sapiens	80-83
25770783-5	2015	Here, we show that in the absence of BLM protein, formaldehyde-treated cells exhibited increased cellular sensitivity, an immediate cell cycle arrest, and an accumulation of chromosome radial structures.	Formaldehyde	50-62	BLM RecQ like helicase	Homo sapiens	37-40
25770783-6	2015	In addition, live-cell imaging experiments demonstrated that formaldehyde-treated cells are dependent on BLM for timely segregation of daughter cells.	Formaldehyde	61-73	BLM RecQ like helicase	Homo sapiens	105-108
26097596-4	2015	FRZB expression was evaluated by immunohistochemistry in formalin-fixed paraffin embedded (FFPE) primary colon carcinoma and paired hepatic metastasis tissues from 136 patients with liver metastasis from colon carcinoma that underwent hepatic resection.	Formaldehyde	57-65	frizzled related protein	Homo sapiens	0-4
25875358-3	2015	The chemoreceptor channel TRPA1 was suggested as primary transducer, but the high concentrations used in the formalin test elicit a similar response in TRPA1 wildtype and knockout animals.	Formaldehyde	109-117	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	152-157
25875358-6	2015	This TRPA1-independent mechanism may underlie formaldehyde-induced pan-neuronal excitation and subsequent inflammation.	Formaldehyde	46-58	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	5-10
25770783-7	2015	Both wild-type and BLM-deficient formaldehyde-treated cells showed an accumulation of 53BP1 and gammaH2AX foci indicative of DNA double-strand breaks (DSBs); however, relative to wild-type cells, the BLM-deficient cells exhibited delayed repair of formaldehyde-induced DSBs.	Formaldehyde	33-45	BLM RecQ like helicase	Homo sapiens	19-22
25770783-7	2015	Both wild-type and BLM-deficient formaldehyde-treated cells showed an accumulation of 53BP1 and gammaH2AX foci indicative of DNA double-strand breaks (DSBs); however, relative to wild-type cells, the BLM-deficient cells exhibited delayed repair of formaldehyde-induced DSBs.	Formaldehyde	33-45	tumor protein p53 binding protein 1	Homo sapiens	86-91
25770783-7	2015	Both wild-type and BLM-deficient formaldehyde-treated cells showed an accumulation of 53BP1 and gammaH2AX foci indicative of DNA double-strand breaks (DSBs); however, relative to wild-type cells, the BLM-deficient cells exhibited delayed repair of formaldehyde-induced DSBs.	Formaldehyde	33-45	BLM RecQ like helicase	Homo sapiens	200-203
25770783-7	2015	Both wild-type and BLM-deficient formaldehyde-treated cells showed an accumulation of 53BP1 and gammaH2AX foci indicative of DNA double-strand breaks (DSBs); however, relative to wild-type cells, the BLM-deficient cells exhibited delayed repair of formaldehyde-induced DSBs.	Formaldehyde	248-260	BLM RecQ like helicase	Homo sapiens	19-22
25770783-8	2015	In response to formaldehyde exposure, we observed co-localization of 53BP1 and BLM foci at the DSB repair site, where ATM-dependent accumulation of formaldehyde-induced BLM foci occurred after the recruitment of 53BP1.	Formaldehyde	15-27	tumor protein p53 binding protein 1	Homo sapiens	69-74
25770783-8	2015	In response to formaldehyde exposure, we observed co-localization of 53BP1 and BLM foci at the DSB repair site, where ATM-dependent accumulation of formaldehyde-induced BLM foci occurred after the recruitment of 53BP1.	Formaldehyde	15-27	tumor protein p53 binding protein 1	Homo sapiens	212-217
25770783-8	2015	In response to formaldehyde exposure, we observed co-localization of 53BP1 and BLM foci at the DSB repair site, where ATM-dependent accumulation of formaldehyde-induced BLM foci occurred after the recruitment of 53BP1.	Formaldehyde	148-160	tumor protein p53 binding protein 1	Homo sapiens	69-74
25770783-9	2015	Together, these findings highlight the significance of functional interactions among ATM, 53BP1, and BLM proteins as responders associated with the repair and tolerance mechanisms induced by formaldehyde.	Formaldehyde	191-203	tumor protein p53 binding protein 1	Homo sapiens	90-95
25770783-9	2015	Together, these findings highlight the significance of functional interactions among ATM, 53BP1, and BLM proteins as responders associated with the repair and tolerance mechanisms induced by formaldehyde.	Formaldehyde	191-203	BLM RecQ like helicase	Homo sapiens	101-104
32262060-5	2015	Treatment of (2.5% glutaraldehyde or formaldehyde for 10 min) autologous human dermal fibroblasts allowed hiPS cells to adhere and grow as undifferentiated colonies characterized by the expression of pluripotency markers such as alkaline phosphatase, Oct-3/4, and stage-specific embryonic antigen-4.	Formaldehyde	37-49	POU class 5 homeobox 1	Homo sapiens	251-258
25789835-4	2015	We evaluated the novel high affinity ALK 1A4 antibody for routine diagnostics in formalin fixed, paraffin-embedded tumor specimens.	Formaldehyde	81-89	ALK receptor tyrosine kinase	Homo sapiens	37-40
25797743-4	2015	Formalin-fixed paraffin embedded specimens were analyzed with hematoxylin and eosin, Ki-67, cleaved caspase-3, CD8, phosphorylated extracellular signal-regulated kinase (ERK), and phosphorylated MEK immunostains.	Formaldehyde	0-8	CD8a molecule	Homo sapiens	111-114
25797743-4	2015	Formalin-fixed paraffin embedded specimens were analyzed with hematoxylin and eosin, Ki-67, cleaved caspase-3, CD8, phosphorylated extracellular signal-regulated kinase (ERK), and phosphorylated MEK immunostains.	Formaldehyde	0-8	mitogen-activated protein kinase 1	Homo sapiens	170-173
25844136-4	2015	While lesioning suppresses the activation of the extracellular signal-regulated kinase (ERK) of the spinal cord in the formalin model, its role in the carrageenan model has not been reported.	Formaldehyde	119-127	Eph receptor B1	Rattus norvegicus	49-86
25844136-4	2015	While lesioning suppresses the activation of the extracellular signal-regulated kinase (ERK) of the spinal cord in the formalin model, its role in the carrageenan model has not been reported.	Formaldehyde	119-127	Eph receptor B1	Rattus norvegicus	88-91
25194563-5	2015	ERCC1 immunohistochemistry was performed on formalin-fixed, paraffin-embedded tissues.	Formaldehyde	44-52	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	0-5
25575713-4	2015	MATERIALS AND METHODS: The expression-and localization pattern of uPAR was investigated in formalin-fixed paraffin-embedded tumor tissue from 149 patients treated with radical cystectomy between 1988 and 2005.	Formaldehyde	91-99	plasminogen activator, urokinase receptor	Homo sapiens	66-70
25889478-5	2015	We also examined the effect of a BLT1 antagonist on formalin-induced pain responses in mice.	Formaldehyde	52-60	leukotriene B4 receptor 1	Mus musculus	33-37
25660619-3	2015	Immunohistochemistry was performed to determine the effects of emulsified sevoflurane on formalin-induced changes of Fos-like immunoreactive (Fos-LI)-positive neurons in the spinal cord.	Formaldehyde	89-97	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	117-120
25660619-3	2015	Immunohistochemistry was performed to determine the effects of emulsified sevoflurane on formalin-induced changes of Fos-like immunoreactive (Fos-LI)-positive neurons in the spinal cord.	Formaldehyde	89-97	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	142-145
25660619-5	2015	Furthermore, Fos-LI-positive neurons were mainly found in the ipsilateral dorsal horn after the injection of formalin.	Formaldehyde	109-117	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	13-16
25774992-6	2015	Formalin-fixed, paraffin-embedded tissue was stained with anti-PD-L1 (clone E1L3N).	Formaldehyde	0-8	CD274 molecule	Homo sapiens	63-68
25592423-7	2015	The spinal neuronal response to the formalin injection into the rat hind paw was also examined through immunohistochemical analysis of c-Fos protein.	Formaldehyde	36-44	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	135-140
25592423-8	2015	Significantly increased numbers of c-Fos-immunoreactive cells were observed in laminae I-II and V-VI of the ipsilateral spinal cord to the site of the formalin injection in rats with neonatal dopamine depletion compared with vehicle-treated rats.	Formaldehyde	151-159	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	35-40
25889478-6	2015	RESULTS: BLT1 knockout mice exhibited markedly attenuated nociceptive responses induced by intraplantar formalin injections.	Formaldehyde	104-112	leukotriene B4 receptor 1	Mus musculus	9-13
25889478-8	2015	Phosphorylation of CREB in the spinal cord after the intraplantar formalin injection was decreased in BLT1 knockout mice.	Formaldehyde	66-74	cAMP responsive element binding protein 1	Mus musculus	19-23
25889478-8	2015	Phosphorylation of CREB in the spinal cord after the intraplantar formalin injection was decreased in BLT1 knockout mice.	Formaldehyde	66-74	leukotriene B4 receptor 1	Mus musculus	102-106
25889478-9	2015	In addition, mice pretreated with a BLT1 antagonist showed reduced nociception and attenuated CREB phosphorylation in the spinal cord after the formalin injection.	Formaldehyde	144-152	leukotriene B4 receptor 1	Mus musculus	36-40
25889478-9	2015	In addition, mice pretreated with a BLT1 antagonist showed reduced nociception and attenuated CREB phosphorylation in the spinal cord after the formalin injection.	Formaldehyde	144-152	cAMP responsive element binding protein 1	Mus musculus	94-98
25805965-0	2015	Recruitment of hypothalamic orexin neurons after formalin injections in adult male rats exposed to a neonatal immune challenge.	Formaldehyde	49-57	hypocretin neuropeptide precursor	Rattus norvegicus	28-34
25889478-10	2015	CONCLUSIONS: Our data suggest that LTB4-BLT1 axis contributes not only to the peripheral inflammation but also to the neuronal activation in the spinal cord induced by intraplantar formalin injections.	Formaldehyde	181-189	leukotriene B4 receptor 1	Mus musculus	40-44
25773691-0	2015	Evaluating the miR-302b and miR-145 expression in formalin-fixed paraffin-embedded samples of esophageal squamous cell carcinoma.	Formaldehyde	50-58	microRNA 145	Homo sapiens	28-35
25805965-4	2015	However, whether neonatal LPS exposure affects the reactivity of the orexin system to formalin-induced inflammatory pain in later life remains to be determined.	Formaldehyde	86-94	hypocretin neuropeptide precursor	Rattus norvegicus	69-75
25695583-4	2015	METHODS: Formalin (1%, 20 microL) was injected subcutaneously into the right hindpaws of male 129S4/SvJaexC57BL/6J (RGS4(+/+) or RGS4(-/-)) mice, and the licking responses were counted for 40 minutes.	Formaldehyde	9-17	regulator of G-protein signaling 4	Mus musculus	116-120
25695583-14	2015	CONCLUSIONS: These findings demonstrated that spinal RGS4 inhibited the endogenous or exogenous OR-mediated antinociceptive effect in the formalin pain test.	Formaldehyde	138-146	regulator of G-protein signaling 4	Mus musculus	53-57
25749582-0	2015	BDNF-TrkB pathway mediates neuroprotection of hydrogen sulfide against formaldehyde-induced toxicity to PC12 cells.	Formaldehyde	71-83	brain-derived neurotrophic factor	Rattus norvegicus	0-4
25749582-0	2015	BDNF-TrkB pathway mediates neuroprotection of hydrogen sulfide against formaldehyde-induced toxicity to PC12 cells.	Formaldehyde	71-83	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	5-9
25568185-5	2015	Finally, we validated RacGAP1 protein expression using formalin-fixed paraffin-embedded samples from 298 CRC patients (Cohort 2) by immunohistochemistry.	Formaldehyde	55-63	Rac GTPase activating protein 1	Homo sapiens	22-29
25418676-6	2015	We further show that (R)-7-(R)-10 displayed excellent anticonvulsant activities and pain-attenuating properties in the animal formalin model.	Formaldehyde	126-134	ribonuclease A family member 3	Rattus norvegicus	21-26
25743118-7	2015	A TRPA1 antagonist, A-967079, reduced pain reaction by 48% (P&lt;0.05) in the AITC test and by 54% (P&lt;0.001) in the early phase of the formalin test.	Formaldehyde	138-146	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	2-7
25547463-0	2015	Loss of ICA69 potentiates long-lasting hyperalgesia after subcutaneous formalin injection into the mouse hindpaw.	Formaldehyde	71-79	islet cell autoantigen 1	Mus musculus	8-13
25617811-9	2015	VEGF upregulation by pro-inflammatory stimuli, IFNgamma, DNCB or formaldehyde is preceded by the production of IL-8, an acute inflammatory phase cytokine.	Formaldehyde	65-77	vascular endothelial growth factor A	Homo sapiens	0-4
25617811-10	2015	Lymphangiogenic VEGF-C gene transcription was significantly increased when NHKs were treated with formaldehyde, DNCB or urushiol, while transcription of VEGF-A and VEGF-B did not change.	Formaldehyde	98-110	vascular endothelial growth factor C	Homo sapiens	16-22
25687494-2	2015	The current study investigated the role of cannabinoid (CB1 and CB2) receptors in modulating formalin-induced nociceptive behavior and mechanical allodynia in the rat.	Formaldehyde	93-101	cannabinoid receptor 1	Rattus norvegicus	56-59
25687494-2	2015	The current study investigated the role of cannabinoid (CB1 and CB2) receptors in modulating formalin-induced nociceptive behavior and mechanical allodynia in the rat.	Formaldehyde	93-101	cannabinoid receptor 2	Rattus norvegicus	64-67
25687494-9	2015	The results indicate that CB1 and CB2 receptors mediate a tonically inhibitory action on formalin-induced inflammatory pain, especially long-term allodynia, in bilateral hind paws.	Formaldehyde	89-97	cannabinoid receptor 1	Rattus norvegicus	26-29
25687494-9	2015	The results indicate that CB1 and CB2 receptors mediate a tonically inhibitory action on formalin-induced inflammatory pain, especially long-term allodynia, in bilateral hind paws.	Formaldehyde	89-97	cannabinoid receptor 2	Rattus norvegicus	34-37
25582503-2	2015	We examined variations of the NAB2-STAT6 fusion gene in 40 cases of SFT using formalin-fixed, paraffin-embedded tissues and secondary genetic alterations of tumor protein p53 (TP53),, platelet-derived growth factor receptor, beta polypeptide (PDGFRB), and telomerase reverse transcriptase (TERT) promoters.	Formaldehyde	78-86	NGFI-A binding protein 2	Homo sapiens	30-34
25582503-2	2015	We examined variations of the NAB2-STAT6 fusion gene in 40 cases of SFT using formalin-fixed, paraffin-embedded tissues and secondary genetic alterations of tumor protein p53 (TP53),, platelet-derived growth factor receptor, beta polypeptide (PDGFRB), and telomerase reverse transcriptase (TERT) promoters.	Formaldehyde	78-86	signal transducer and activator of transcription 6	Homo sapiens	35-40
25837919-2	2015	We previously reported that TRPM2 deficiency attenuated inflammatory and neuropathic pain in some pain mouse models, including formalin- or carrageenan-induced inflammatory pain, and peripheral nerve injury-induced neuropathic pain models, while it had no effect on the basal mechanical and thermal nociceptive sensitivities.	Formaldehyde	127-135	transient receptor potential cation channel, subfamily M, member 2	Mus musculus	28-33
25617811-8	2015	In addition, common human haptenic allergens such as avobenzone, formaldehyde and urushiol, also induced the keratinocyte-derived VEGF production.	Formaldehyde	65-77	vascular endothelial growth factor A	Homo sapiens	130-134
25784959-2	2015	RESULTS: We show that during the transformation process, nucleosome-depleted regions (defined by formaldehyde-assisted isolation of regulatory elements (FAIRE)) are largely unchanged and that both before and during transformation, STAT3 binds almost exclusively to previously open chromatin regions.	Formaldehyde	97-109	signal transducer and activator of transcription 3	Homo sapiens	231-236
25916782-2	2015	METHODS: For determining the role of ZIP on pain-induced aversion, the effects of intra-PAG injection of ZIP on formalin-induced conditioned place avoidance (F-CPA) was investigated.	Formaldehyde	112-120	sequestosome 1	Rattus norvegicus	105-108
25684949-3	2015	The protein expression of FGFR4 in formalin-fixed, paraffin-embedded (FFPE) GC tissues was determined by immunohistochemical (IHC) analysis.	Formaldehyde	35-43	fibroblast growth factor receptor 4	Homo sapiens	26-31
25916782-3	2015	To determine the role of ZIP on pain perception, formalin-induced inflammatory pain model was established and the effects of intra-PAG injection of ZIP on formalin-induced nociceptive behaviors was investigated.	Formaldehyde	155-163	sequestosome 1	Rattus norvegicus	148-151
25564098-2	2015	In this work, the apparent HLCs for formaldehyde aqueous solutions were determined in the concentration range from 0.01% to 1% (w/w) and at different temperatures (23, 40, and 55  C) by a static headspace extraction method.	Formaldehyde	36-48	holocarboxylase synthetase	Homo sapiens	27-31
25564098-6	2015	By applying the measured HLCs, the formaldehyde overall liquid-phase mass transfer coefficients (KOLs) were determined to be in the range of 8.12 x 10(-5) to 2.30 x 10(-4) m/h, and the overall gas-phase mass transfer coefficients were between 2.84 and 13.4 m/h.	Formaldehyde	35-47	holocarboxylase synthetase	Homo sapiens	25-29
25527510-4	2015	Expression and translocation of the ALK gene were analyzed by immunohistochemistry (IHC), fluorescence in situ hybridization (FISH), and digital multiplexed gene expression (DMGE) analysis in formalin-fixed paraffin-embedded tissues.	Formaldehyde	192-200	ALK receptor tyrosine kinase	Homo sapiens	36-39
25155396-6	2015	METHODS: Computer-assisted whole-slide analysis, together with enzymatic epitope retrieval, was used for CD31-based microvessel quantification in 131 pretreatment formalin-fixed and paraffin-embedded biopsies from three bone tumor centers.	Formaldehyde	163-171	platelet and endothelial cell adhesion molecule 1	Homo sapiens	105-109
25449583-11	2015	Hippocampal IL-1beta levels were increased in LPS-treated adult but not preadolescent rats in response to formalin injection.	Formaldehyde	106-114	interleukin 1 beta	Rattus norvegicus	12-20
24917463-0	2015	MicroRNA expression signatures for the prediction of BRCA1/2 mutation-associated hereditary breast cancer in paraffin-embedded formalin-fixed breast tumors.	Formaldehyde	127-135	BRCA1 DNA repair associated	Homo sapiens	53-60
25662247-9	2015	The emission ratios relative to toluene for formaldehyde, acetaldehyde, and acetone were determined to be 0.10, 0.20 and 0.40 ppb/ppb, respectively.	Formaldehyde	44-56	histatin 1	Homo sapiens	126-129
25430495-2	2015	METHODS: Genomic analysis for KRAS gene mutation was performed on formalin fixed paraffin embedded (FFPE) cancer patient tissue that was dissected using the mesodissection platform.	Formaldehyde	66-74	KRAS proto-oncogene, GTPase	Homo sapiens	30-34
25662247-9	2015	The emission ratios relative to toluene for formaldehyde, acetaldehyde, and acetone were determined to be 0.10, 0.20 and 0.40 ppb/ppb, respectively.	Formaldehyde	44-56	histatin 1	Homo sapiens	130-133
25659388-5	2015	METHODS AND MATERIALS: In this retrospective study, we performed polymerase chain reaction (PCR) amplification and deoxyribonucleic acid (DNA) sequencing of KIT (exons 9, 11, 13, and 17) and PDGFRA (exons 12 and 18) genes in 20 FFPE (formalin-fixed, paraffin-embedded) and 5 frozen GIST samples.	Formaldehyde	234-242	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	157-160
24794145-5	2015	We found that some GABAergic neurons in the CeC received parabrachial nucleus (PBN) derived CGRP innervations and some of these GABAergic neurons can be activated by subcutaneous injection of formalin.	Formaldehyde	192-200	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	92-96
25673198-0	2015	Formaldehyde induces the bone marrow toxicity in mice by regulating the expression of Prx3 protein.	Formaldehyde	0-12	peroxiredoxin 3	Mus musculus	86-90
25391650-9	2015	Formaldehyde-assisted isolation of regulatory elements (FAIRE) revealed chromatin conformation changes that were reliant on MED25, indicating that MED25 induced a permissive chromatin state that reflected increases in CYP2C9 mRNA.	Formaldehyde	0-12	mediator complex subunit 25	Homo sapiens	124-129
25427744-4	2015	CEACAM6 epitope recognized by AP11 was well preserved in formalin-fixed and paraffin-embedded tissues.	Formaldehyde	57-65	CEA cell adhesion molecule 6	Homo sapiens	0-7
25433814-2	2015	We used immunohistochemistry to evaluate a polyclonal anti-Btk antibody on formalin-fixed paraffin-embedded tissue blocks.	Formaldehyde	75-83	Bruton tyrosine kinase	Homo sapiens	59-62
25391650-9	2015	Formaldehyde-assisted isolation of regulatory elements (FAIRE) revealed chromatin conformation changes that were reliant on MED25, indicating that MED25 induced a permissive chromatin state that reflected increases in CYP2C9 mRNA.	Formaldehyde	0-12	mediator complex subunit 25	Homo sapiens	147-152
25391650-9	2015	Formaldehyde-assisted isolation of regulatory elements (FAIRE) revealed chromatin conformation changes that were reliant on MED25, indicating that MED25 induced a permissive chromatin state that reflected increases in CYP2C9 mRNA.	Formaldehyde	0-12	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	218-224
25453775-6	2015	Furthermore, blockade of the EphB receptors by intrathecal injection of EphB2-Fc reduced formalin-induced inflammatory, chronic constrictive injury (CCI)-induced neuropathic, and tibia bone cavity tumor cell implantation (TCI)-induced bone cancer pain behaviors, which were accompanied by decreased expression of spinal PKAca and p-CREB.	Formaldehyde	89-97	Eph receptor B2	Mus musculus	72-77
25445371-8	2015	In the superficial dorsal horn of the spinal cord (laminae I and II), the fluorescence intensities for Ang II and phospho-p38 MAPK were both significantly increased on the ipsilateral side 3 min after the injection of formalin compared to saline-treated controls.	Formaldehyde	218-226	mitogen-activated protein kinase 14	Mus musculus	122-125
25445371-8	2015	In the superficial dorsal horn of the spinal cord (laminae I and II), the fluorescence intensities for Ang II and phospho-p38 MAPK were both significantly increased on the ipsilateral side 3 min after the injection of formalin compared to saline-treated controls.	Formaldehyde	218-226	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	103-109
25445371-11	2015	These results indicate that losartan produces an antinociceptive effect through the inhibition of p38 MAPK phosphorylation in the mouse formalin test and that Ang II may act as a neurotransmitter and/or neuromodulator in the spinal transmission of nociceptive information.	Formaldehyde	136-144	mitogen-activated protein kinase 14	Mus musculus	98-101
25025444-12	2015	We conclude that RNAscope is a highly sensitive and specific, semiquantitative in situ hybridization method of FGF23 mRNA detection applicable to formalin-fixed, paraffin-embedded tissues.	Formaldehyde	146-154	fibroblast growth factor 23	Homo sapiens	111-116
25580690-7	2015	Regarding its antinociceptive properties, IM-3 showed efficacy in the acetic acid-induced writhing test by increasing the latency of the first writhe and reducing the number of writhes, as well as reducing the paw licking time in the second phase of the formalin test.	Formaldehyde	254-262	immunoregulatory 3	Mus musculus	42-46
25674493-0	2015	Performance of a novel KRAS mutation assay for formalin-fixed paraffin embedded tissues of colorectal cancer.	Formaldehyde	47-55	KRAS proto-oncogene, GTPase	Homo sapiens	23-27
25850206-6	2015	All the extracts produced significant anti-inflammatory effect however, ether extract produced maximum effect 34% inhibition (p &lt; 0.001) against carrageenan and 22% (p &lt; 0.01) inhibition against egg albumin induced paw edema in mice at the end of 3 h. Ether extract produced prominent analgesic effect 77% (p &lt; 0.001) inhibition in acetic acid induced abdominal writhing and 59% inhibition in formalin induced paw licking model in mice, respectively.	Formaldehyde	402-410	albumin	Mus musculus	205-212
25367384-0	2015	Formaldehyde-fixed brain tissue from spontaneously ill alpha-synuclein transgenic mice induces fatal alpha-synucleinopathy in transgenic hosts.	Formaldehyde	0-12	synuclein, alpha	Mus musculus	55-70
25735325-5	2015	GPC3 immunohistochemistry was applied in the pathological diagnosis of hepatoblastoma using the monoclonal antibodies with formalin-fixed and paraffin-embedded specimens.	Formaldehyde	123-131	glypican 3	Homo sapiens	0-4
26225699-5	2015	Formalin fixed paraffin embedded sections were stained with a monoclonal antibody against CK13 using the Envision technique.	Formaldehyde	0-8	keratin 13	Homo sapiens	90-94
25550598-4	2015	MATERIALS AND METHODS: The expression levels of different microRNAs (miR-21, miR-27a, miR-34a, miR-155, miR-196a, miR-203) were determined in formalin-fixed paraffin-embedded (FFPE) human HPV-positive cervical dysplastic and tumorous tissue samples using quantitative real-time PCR (qPCR).	Formaldehyde	142-150	microRNA 21	Homo sapiens	69-75
25550598-4	2015	MATERIALS AND METHODS: The expression levels of different microRNAs (miR-21, miR-27a, miR-34a, miR-155, miR-196a, miR-203) were determined in formalin-fixed paraffin-embedded (FFPE) human HPV-positive cervical dysplastic and tumorous tissue samples using quantitative real-time PCR (qPCR).	Formaldehyde	142-150	microRNA 27a	Homo sapiens	77-84
25550598-4	2015	MATERIALS AND METHODS: The expression levels of different microRNAs (miR-21, miR-27a, miR-34a, miR-155, miR-196a, miR-203) were determined in formalin-fixed paraffin-embedded (FFPE) human HPV-positive cervical dysplastic and tumorous tissue samples using quantitative real-time PCR (qPCR).	Formaldehyde	142-150	microRNA 34a	Homo sapiens	86-93
25550598-4	2015	MATERIALS AND METHODS: The expression levels of different microRNAs (miR-21, miR-27a, miR-34a, miR-155, miR-196a, miR-203) were determined in formalin-fixed paraffin-embedded (FFPE) human HPV-positive cervical dysplastic and tumorous tissue samples using quantitative real-time PCR (qPCR).	Formaldehyde	142-150	microRNA 155	Homo sapiens	95-102
25550598-4	2015	MATERIALS AND METHODS: The expression levels of different microRNAs (miR-21, miR-27a, miR-34a, miR-155, miR-196a, miR-203) were determined in formalin-fixed paraffin-embedded (FFPE) human HPV-positive cervical dysplastic and tumorous tissue samples using quantitative real-time PCR (qPCR).	Formaldehyde	142-150	microRNA 203a	Homo sapiens	114-121
26328487-2	2015	Recently, we determined that the sigma-1 receptor antagonist BD1047 dose-dependently reduced nociceptive responses in a mouse orofacial formalin model.	Formaldehyde	136-144	sigma non-opioid intracellular receptor 1	Mus musculus	33-49
25629055-6	2015	Moreover, Ddo gene deletion exacerbated the nocifensive responses in the formalin test and slightly reduced pain thresholds in neuropathic mice up to 7 days after chronic constriction injury.	Formaldehyde	73-81	D-aspartate oxidase	Mus musculus	10-13
25951497-10	2015	Upregulation of miR-21 and miR-146a was also detected in formalin-fixed, paraffin-embedded UM, suggesting that VH or serum alterations in UM could be the consequence of disregulation arising from tumoral cells.	Formaldehyde	57-65	microRNA 21	Homo sapiens	16-22
25951497-10	2015	Upregulation of miR-21 and miR-146a was also detected in formalin-fixed, paraffin-embedded UM, suggesting that VH or serum alterations in UM could be the consequence of disregulation arising from tumoral cells.	Formaldehyde	57-65	microRNA 146a	Homo sapiens	27-35
26160036-4	2015	METHODS: The expression levels of miR-495 was examined in 62 archival formalin-fixed paraffin-embedded (FFPE) medulloblastoma specimens using TaqMan Real-time Quantitative PCR arrays.	Formaldehyde	70-78	microRNA 495	Homo sapiens	34-41
25214475-8	2015	ZNF165 protein expression was demonstrated on archival formalin-fixed, paraffin-embedded (FFPE) bladder tissues using IHC and nuclear staining pattern was detected.	Formaldehyde	55-63	zinc finger protein 165	Homo sapiens	0-6
30154993-4	2015	A detailed mechanistic study using DFT calculations shows that a sequential series of hydride transfer and protonolysis steps can account for the transformation of CO2via formate/formic acid to hydroxymethanolate/formaldehyde and finally methanolate/methanol within the coordination sphere of a single Ru-Triphos-fragment.	Formaldehyde	213-225	complement C2	Homo sapiens	164-167
25345606-8	2015	In the case of pathological pain, for example, formalin injection induced inflammatory pain and sciatic nerve constriction induced neuropathic pain, NT also shows antinociceptive effects.	Formaldehyde	47-55	neurotensin	Homo sapiens	149-151
25483719-8	2015	Additionally, EOHP/ beta-CD improves pharmacological profile of EOHP alone in formalin-induced pain protocol in mice.	Formaldehyde	78-86	beta-carotene oxygenase 1	Mus musculus	20-27
25280797-9	2015	Moreover, a similar result for small interfering RNA (siRNA)-mediated Apob mRNA knockdown was obtained from tissues fixed in formalin solution for 3months to 4years, and was found to be comparable to results obtained with frozen liver tissues.	Formaldehyde	125-133	apolipoprotein B	Homo sapiens	70-74
26191531-8	2015	Dual label immunohistochemistry on formalin-fixed paraffin-embedded tumor tissue revealed reduced expression of tropoelastin in LANA positive spindle cell regions quantified by Ariol SL-50 scanning analysis.	Formaldehyde	35-43	elastin	Homo sapiens	112-124
26191531-8	2015	Dual label immunohistochemistry on formalin-fixed paraffin-embedded tumor tissue revealed reduced expression of tropoelastin in LANA positive spindle cell regions quantified by Ariol SL-50 scanning analysis.	Formaldehyde	35-43	LANA	Human gammaherpesvirus 8	128-132
25994134-9	2015	Such abnormal behaviors of formyl-Cbl suggest that it mainly exists in a hydrated form as formaldehyde.	Formaldehyde	90-102	Cbl proto-oncogene	Homo sapiens	34-37
25447449-0	2015	Central adenosine A1 and A2A receptors mediate the antinociceptive effects of neuropeptide S in the mouse formalin test.	Formaldehyde	106-114	neuropeptide S	Mus musculus	78-92
25797291-4	2015	The expression of TLR4 and TLR5 was evaluated by immunohistochemisty in formalin-fixed paraffin-embedded prostate tissue from wild-type (WT) and TRAMP mice.	Formaldehyde	72-80	toll-like receptor 4	Mus musculus	18-22
25797291-4	2015	The expression of TLR4 and TLR5 was evaluated by immunohistochemisty in formalin-fixed paraffin-embedded prostate tissue from wild-type (WT) and TRAMP mice.	Formaldehyde	72-80	toll-like receptor 5	Mus musculus	27-31
25766605-3	2015	Therefore, we surveyed these TLR4 SNPs by using formalin-fixed and paraffin-embedded tissue blocks obtained from autopsies of patients with invasive pulmonary aspergillosis.	Formaldehyde	48-56	toll like receptor 4	Homo sapiens	29-33
25429837-6	2015	Immunohistochemistry analysis was performed on formalin-fixed paraffin-embedded section of 116 cases of EOCs and indicated that USP14 was significantly associated with clinical pathologic variables.	Formaldehyde	47-55	ubiquitin specific peptidase 14	Homo sapiens	128-133
26337566-3	2015	METHODS: The expression of AMPKalpha1, AMPKalpha2 and phosphorylated AMPKalpha (p-AMPKalpha) was determined immunohistochemically in 524 formalin-fixed, paraffin-embedded malignant and premalignant cervical tissues.	Formaldehyde	137-145	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	27-37
26103892-4	2015	We identified five different BRAF mutations in a single assay analyzing 75 different formalin-fixed paraffin-embedded samples of cutaneous melanoma metastases from 29 patients.	Formaldehyde	85-93	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	29-33
25282336-0	2015	Age-related formaldehyde interferes with DNA methyltransferase function, causing memory loss in Alzheimer"s disease.	Formaldehyde	12-24	renin binding protein	Homo sapiens	0-3
25282336-0	2015	Age-related formaldehyde interferes with DNA methyltransferase function, causing memory loss in Alzheimer"s disease.	Formaldehyde	12-24	DNA methyltransferase 1	Homo sapiens	41-62
25449358-0	2015	Participation of peripheral P2Y1, P2Y6 and P2Y11 receptors in formalin-induced inflammatory pain in rats.	Formaldehyde	62-70	purinergic receptor P2Y1	Rattus norvegicus	28-32
26389729-3	2015	METHODS: miR-148a expression was measured by qRT-PCR in patients with colorectal adenoma (n = 21) and CRC (stage I-IV, n = 159) using formalin-fixed paraffin-embedded tissue samples.	Formaldehyde	134-142	microRNA 148a	Homo sapiens	9-17
25449358-0	2015	Participation of peripheral P2Y1, P2Y6 and P2Y11 receptors in formalin-induced inflammatory pain in rats.	Formaldehyde	62-70	pyrimidinergic receptor P2Y6	Rattus norvegicus	34-38
25449358-3	2015	This study assessed the role of peripheral P2Y1, P2Y6 and P2Y11 receptors in formalin-induced inflammatory pain.	Formaldehyde	77-85	purinergic receptor P2Y1	Rattus norvegicus	43-47
25449358-8	2015	Results suggest that peripheral activation of P2Y1, P2Y6 and P2Y11 receptors plays a pronociceptive role in formalin-induced pain.	Formaldehyde	108-116	purinergic receptor P2Y1	Rattus norvegicus	46-50
25449358-8	2015	Results suggest that peripheral activation of P2Y1, P2Y6 and P2Y11 receptors plays a pronociceptive role in formalin-induced pain.	Formaldehyde	108-116	pyrimidinergic receptor P2Y6	Rattus norvegicus	52-56
26662140-2	2015	Here we use quantitative real-time polymerase chain reaction (qRT-PCR) to investigate the expression of the microRNAs resident on chromosome 21 (miR-ch21) in laser capture microdissected (LCM) tissues from formalin-fixed paraffin-embedded (FFPE) archived, prostate adenocarcinoma samples.	Formaldehyde	206-214	MLX interacting protein	Homo sapiens	145-148
25515240-8	2014	DEK expression was determined by immunohistochemistry in 67 formalin-fixed paraffin-embedded tumour samples from metastatic colorectal cancer patients treated with irinotecan-based therapy as first-line treatment.	Formaldehyde	60-68	DEK proto-oncogene	Homo sapiens	0-3
25387985-4	2014	For the reactions of methanal and methanoic acid with H atoms and OH, HO2, and CH3 radicals, the calculated relative electronic energies were obtained with the CCSD(T)/cc-pVXZ (where X = D, T, and Q) method and were extrapolated to the complete basis set limit.	Formaldehyde	21-29	heme oxygenase 2	Homo sapiens	70-73
25566506-3	2014	We have recently developed an FA triple-staining immunofluorescence based method (FATSI) to evaluate FANCD2 foci formation in formalin fixed paraffin-embedded (FFPE) tumor samples.	Formaldehyde	126-134	FA complementation group D2	Homo sapiens	101-107
24748127-7	2014	In formalin-fixed paraffin-embedded and microdissected frozen samples, miR-373 expression was significantly down-regulated in pancreatic cancer compared with that in healthy pancreas (P &lt; 0.001 and P = 0.005, respectively).	Formaldehyde	3-11	microRNA 373	Homo sapiens	71-78
25663984-0	2014	Effect of adenoviral delivery of prodynorphin gene on experimental inflammatory pain induced by formalin in rats.	Formaldehyde	96-104	prodynorphin	Rattus norvegicus	33-45
25663984-5	2014	In this study we investigated the changes in pain behaviors, spinal PDYN mRNA expression and dynorphin A production on formalin-induced pain in rats receiving the pretreatment of adenoviral delivery of PDYN.	Formaldehyde	119-127	prodynorphin	Rattus norvegicus	202-206
25663984-6	2014	Our results showed that the adenoviral transfer of PDYN gene was sufficient to reduce pain behaviors resulting from formalin injection, and the antinociceptive effect after receiving the pretreatment of adenoviral delivery of PDYN was mediated at the level of the spinal cord via KOR.	Formaldehyde	116-124	prodynorphin	Rattus norvegicus	51-55
25663984-6	2014	Our results showed that the adenoviral transfer of PDYN gene was sufficient to reduce pain behaviors resulting from formalin injection, and the antinociceptive effect after receiving the pretreatment of adenoviral delivery of PDYN was mediated at the level of the spinal cord via KOR.	Formaldehyde	116-124	prodynorphin	Rattus norvegicus	226-230
25525358-4	2014	MATERIALS AND METHODS: EGFR gene mutations were detected by QDs-IHC, IHC, and ADx-ARMS in 65 cases of NSCLC composed of 55 formalin-fixed, paraffin-embedded specimens and ten pleural effusion cell blocks, including 13 squamous cell carcinomas, two adenosquamous carcinomas, and 50 adenocarcinomas.	Formaldehyde	123-131	epidermal growth factor receptor	Homo sapiens	23-27
25444499-3	2014	Our objective was to investigate the clinicopathological contribution of the miR-148a expression in HCC formalin-fixed paraffin-embedded (FFPE) tissues.	Formaldehyde	104-112	microRNA 148a	Homo sapiens	77-85
25118810-10	2014	Unfavorable risk cases potentially also responding to BRAF-inhibitory therapy can be identified by mutation testing using archival formaldehyde-fixed, paraffin-embedded tumor samples.	Formaldehyde	131-143	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	54-58
25481017-0	2014	Detection of immunoglobulin IGH gene rearrangements on formalin-fixed, paraffin embedded tissue in lymphoid malignancies.	Formaldehyde	55-63	immunoglobulin heavy locus	Homo sapiens	28-31
25124473-4	2014	METHODS: The association between FOXC1 and EGFR expression in human breast cancer was examined by immunohistochemistry in formalin-fixed tissues and analysis of the TCGA database.	Formaldehyde	122-130	epidermal growth factor receptor	Homo sapiens	43-47
24945428-0	2014	Results of first proficiency test for KRAS testing with formalin-fixed, paraffin-embedded cell lines in China.	Formaldehyde	56-64	KRAS proto-oncogene, GTPase	Rattus norvegicus	38-42
25236569-2	2014	In the present study, the BrightGen HER2 RT-qDx (Syantra, Calgary, Canada), which is based on a one-tube nested RT-qPCR method that detects HER2 mRNA overexpression, was clinically evaluated in a total of 237 formalin-fixed paraffin-embedded (FFPE) tissue samples from breast cancer patients.	Formaldehyde	209-217	erb-b2 receptor tyrosine kinase 2	Homo sapiens	36-40
25420961-8	2014	IHC staining of formalin-fixed paraffin-embedded sections with specific antibodies showed that aurora and stathmin are expressed in BC.	Formaldehyde	16-24	stathmin 1	Homo sapiens	106-114
25674264-2	2014	METHODS: The immunohistochemical expression of p15(INK4b), p16(INK4a) and p21(Waf1/Cip1) were investigated in formalin-fixed paraffin-embedded specimens from 19 NCE, 51 CIN and 21 SCC cases, respectively.	Formaldehyde	110-118	cyclin dependent kinase inhibitor 2B	Homo sapiens	47-50
25771866-0	2014	Formaldehyde-induced histone H3 phosphorylation via JNK and the expression of proto-oncogenes.	Formaldehyde	0-12	mitogen-activated protein kinase 8	Homo sapiens	52-55
25259564-4	2014	METHODS: In this study, the authors investigated MMP2 and TIMP2 gene polymorphisms in formalin-fixed paraffin-embedded tissue samples obtained from meningioma patients who had previously undergone surgery at the authors" institution.	Formaldehyde	86-94	matrix metallopeptidase 2	Homo sapiens	49-53
25259564-4	2014	METHODS: In this study, the authors investigated MMP2 and TIMP2 gene polymorphisms in formalin-fixed paraffin-embedded tissue samples obtained from meningioma patients who had previously undergone surgery at the authors" institution.	Formaldehyde	86-94	TIMP metallopeptidase inhibitor 2	Homo sapiens	58-63
25175638-1	2014	Intraplantar injection of 0.4% formalin into the rat hind paw leads to a biphasic nociceptive response; an "acute" phase (0-15 min) and "tonic" phase (16-120 min), which is accompanied by significant phosphorylation of extracellular signal-regulated kinase (ERK)1/2 in the contralateral striatum at 120 min post-formalin injection.	Formaldehyde	31-39	mitogen activated protein kinase 3	Rattus norvegicus	219-265
25416048-3	2014	To address this problem, immunohistochemistry was performed to detect the expression and the subcellular localization of PDK1 protein in 120 paired of formalin-fixed and paraffin-embedded cancerous and adjacent non-cancerous tissues.	Formaldehyde	151-159	3-phosphoinositide dependent protein kinase 1	Homo sapiens	121-125
25238939-8	2014	Moreover, RT-PCR using formalin-fixed, paraffin-embedded tissue from the right lung cancer also demonstrated EML4-ALK variant 1 fusion gene.	Formaldehyde	23-31	EMAP like 4	Homo sapiens	109-113
25281928-7	2014	We found TRPV4 to be important for trigeminal nocifensive behavior evoked by formalin whisker pad injections.	Formaldehyde	77-85	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	9-14
25238939-8	2014	Moreover, RT-PCR using formalin-fixed, paraffin-embedded tissue from the right lung cancer also demonstrated EML4-ALK variant 1 fusion gene.	Formaldehyde	23-31	ALK receptor tyrosine kinase	Homo sapiens	114-117
25281928-10	2014	Furthermore, cellular studies in primary TG neurons and in heterologous TRPV4-expressing cells suggest that TRPV4 can be activated directly by formalin to gate Ca(2+).	Formaldehyde	143-151	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	72-77
25281928-10	2014	Furthermore, cellular studies in primary TG neurons and in heterologous TRPV4-expressing cells suggest that TRPV4 can be activated directly by formalin to gate Ca(2+).	Formaldehyde	143-151	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	108-113
25443722-0	2014	Role of TRPV1 and ASIC3 in formalin-induced secondary allodynia and hyperalgesia.	Formaldehyde	27-35	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	8-13
25281928-11	2014	Using TRPA1-blocker and Trpa1(-/-) mice, we found that both TRP channels co-contribute to the formalin trigeminal pain response.	Formaldehyde	94-102	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	6-11
25281928-11	2014	Using TRPA1-blocker and Trpa1(-/-) mice, we found that both TRP channels co-contribute to the formalin trigeminal pain response.	Formaldehyde	94-102	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	24-29
25443722-0	2014	Role of TRPV1 and ASIC3 in formalin-induced secondary allodynia and hyperalgesia.	Formaldehyde	27-35	acid sensing ion channel subunit 3	Rattus norvegicus	18-23
25443722-8	2014	TRPV1 and ASIC3 proteins were expressed in dorsal root ganglion in normal conditions, and 1% formalin injection increased expression of both proteins in this location at 1 and 6 days compared to naive rats.	Formaldehyde	93-101	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	0-5
25443722-8	2014	TRPV1 and ASIC3 proteins were expressed in dorsal root ganglion in normal conditions, and 1% formalin injection increased expression of both proteins in this location at 1 and 6 days compared to naive rats.	Formaldehyde	93-101	acid sensing ion channel subunit 3	Rattus norvegicus	10-15
25443722-9	2014	CONCLUSIONS: Data suggest that TRPV1 and ASIC3 participate in the development and maintenance of long-lasting secondary allodynia and hyperalgesia induced by formalin in rats.	Formaldehyde	158-166	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	31-36
25443722-9	2014	CONCLUSIONS: Data suggest that TRPV1 and ASIC3 participate in the development and maintenance of long-lasting secondary allodynia and hyperalgesia induced by formalin in rats.	Formaldehyde	158-166	acid sensing ion channel subunit 3	Rattus norvegicus	41-46
25451260-11	2014	Furthermore, formaldehyde-assisted isolation of regulatory elements (FAIRE)-quantitative polymerase chain reaction (qPCR) experiments revealed that depletion of FLII caused a reduction in chromatin accessibility at the COL1A2 promoter.	Formaldehyde	13-25	flightless I	Drosophila melanogaster	161-165
25156059-4	2014	METHODS: YWHAZ expression was assessed by immunohistochemistry on formalin-fixed paraffin-embedded tissue from 213 men who underwent radical prostatectomy.	Formaldehyde	66-74	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	Homo sapiens	9-14
25063314-3	2014	HO-1 expression was assessed in 215 formalin-fixed bladder cancer specimens by immunohistochemistry.	Formaldehyde	36-44	heme oxygenase 1	Homo sapiens	0-4
25432794-6	2014	For detection of the NAB2-STAT6 fusion gene, RT-PCR was performed using RNA extracted from formalin-fixed and paraffin-embedded tissues.	Formaldehyde	91-99	NGFI-A binding protein 2	Homo sapiens	21-25
25432794-6	2014	For detection of the NAB2-STAT6 fusion gene, RT-PCR was performed using RNA extracted from formalin-fixed and paraffin-embedded tissues.	Formaldehyde	91-99	signal transducer and activator of transcription 6	Homo sapiens	26-31
25319141-1	2014	The rate constant of the H-abstraction reaction of formaldehyde (CH2O) by hydrogen atoms (H), CH2O + H = H2 + HCO, has been studied behind reflected shock waves with use of a sensitive mid-IR laser absorption diagnostic for CO, over temperatures of 1304-2006 K and at pressures near 1 atm.	Formaldehyde	51-63	fibroblast growth factor receptor 1	Homo sapiens	94-113
25400523-2	2014	The conventional mechanism for the dealkylation of N1-methyl adenine (1-meA) catalyzed by AlkB after the formation of FeIV-oxo is comprised by a reorientation of the oxo moiety, hydrogen abstraction, OH rebound from the Fe atom to the methyl adduct, and the dissociation of the resulting methoxide to obtain the repaired adenine base and formaldehyde.	Formaldehyde	338-350	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	90-94
25302535-6	2014	The primary antibody conjugated fluorescent NCs could also clearly delineate EGFR over-expressing cells on clinical tumor tissues processed by formalin fixation as well as cryopreservation with a specificity of 86% and accuracy of 88%, in comparison to immunohistochemistry.	Formaldehyde	143-151	epidermal growth factor receptor	Mus musculus	77-81
25319141-1	2014	The rate constant of the H-abstraction reaction of formaldehyde (CH2O) by hydrogen atoms (H), CH2O + H = H2 + HCO, has been studied behind reflected shock waves with use of a sensitive mid-IR laser absorption diagnostic for CO, over temperatures of 1304-2006 K and at pressures near 1 atm.	Formaldehyde	65-69	fibroblast growth factor receptor 1	Homo sapiens	94-113
24737069-4	2014	METHODS/PATIENTS: Stromal expression of CA IX in 361 formalin-fixed, paraffin-embedded specimens of invasive esophageal cancers, 206 adenocarcinoma (AC) and 155 squamous cell carcinoma (SCC), was investigated.	Formaldehyde	53-61	carbonic anhydrase 9	Homo sapiens	40-45
25373709-3	2014	METHODS: The immunohistochemical expression of p-Smad2 was evaluated in 78 formalin-fixed paraffin-embedded surgical resection specimens from clinical stage I to IIIA non-small cell lung cancer.	Formaldehyde	75-83	SMAD family member 2	Homo sapiens	49-54
24630684-4	2014	ERG immunohistochemical staining was performed on diagnostic paraffin-embedded formalin-fixed sections with a ready-to-use kit (anti-ERG, EPR3864).	Formaldehyde	79-87	ETS transcription factor ERG	Homo sapiens	0-3
25279206-5	2014	HER-2 was detected by immunohistochemical examination on sections from formalin-fixed, paraffin-embedded tumor tissues.	Formaldehyde	71-79	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-5
25079367-6	2014	This increased reactivity to tonic pain was accompanied by enhanced formalin-evoked c-fos staining of second order nociceptive neurons at Tau-null dorsal horn.	Formaldehyde	68-76	FBJ osteosarcoma oncogene	Mus musculus	84-89
25429177-13	2014	CONCLUSION: Both Amylin and Salmon Calcitonin inhibit formalin induced c-Fos expression in the rat lumbar spinal cord when administered intrathecally.	Formaldehyde	54-62	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	71-76
25458692-2	2014	With the aid of ultrasonication, melamine-formaldehyde-tetraoxalyl-ethylenediamine chelating resins were grafted on activated carbon (MFT/AC).	Formaldehyde	42-54	solute carrier family 25 member 32	Homo sapiens	134-137
25263855-2	2014	EGFR mutations are commonly tested by Sanger sequencing or allele specific polymerase chain reaction (ASPCR) on formalin-fixed paraffin-embedded (FFPE) samples including cell blocks (CB) that may fail due to absence of tumor cells.	Formaldehyde	112-120	epidermal growth factor receptor	Homo sapiens	0-4
25429177-0	2014	Intrathecal Amylin and Salmon Calcitonin Affect Formalin Induced c-Fos Expression in the Spinal Cord of Rats.	Formaldehyde	48-56	islet amyloid polypeptide	Rattus norvegicus	12-18
25429177-0	2014	Intrathecal Amylin and Salmon Calcitonin Affect Formalin Induced c-Fos Expression in the Spinal Cord of Rats.	Formaldehyde	48-56	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	65-70
25429177-3	2014	We assessed the expression of c-Fos in response to intraplantar formalin in the lumbar regions of the spinal cord in conscious rats.	Formaldehyde	64-72	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	30-35
25429177-7	2014	RESULTS: Two hours after formalin stimulation, rats pretreated intrathecally by either Amylin or Salmon Calcitonin, showed lower numbers of c-Fos immunoreactive nuclei in their lumbar spinal cord as compared to rats pretreated with saline.	Formaldehyde	25-33	islet amyloid polypeptide	Rattus norvegicus	87-93
25429177-13	2014	CONCLUSION: Both Amylin and Salmon Calcitonin inhibit formalin induced c-Fos expression in the rat lumbar spinal cord when administered intrathecally.	Formaldehyde	54-62	islet amyloid polypeptide	Rattus norvegicus	17-23
25035100-5	2014	TERT promoter mutation analysis on DNA from formalin-fixed, paraffin-embedded specimens was performed by SNaPshot analysis.	Formaldehyde	44-52	telomerase reverse transcriptase	Mus musculus	0-4
25275568-4	2014	Two relevant pathways for desorption of formaldehyde are found with intrinsic barriers for the redox step of 1.0 and 1.4 eV (HSE+D).	Formaldehyde	40-52	hydroxysteroid 17-beta dehydrogenase 6	Homo sapiens	125-128
23160383-9	2014	In addition, the activations of necrosis factor-kappaB (NF-kappaB) and activator protein 1 (AP-1) were induced by the formaldehyde treatment.	Formaldehyde	118-130	nuclear factor kappa B subunit 1	Homo sapiens	32-54
23160383-9	2014	In addition, the activations of necrosis factor-kappaB (NF-kappaB) and activator protein 1 (AP-1) were induced by the formaldehyde treatment.	Formaldehyde	118-130	nuclear factor kappa B subunit 1	Homo sapiens	56-65
23160383-9	2014	In addition, the activations of necrosis factor-kappaB (NF-kappaB) and activator protein 1 (AP-1) were induced by the formaldehyde treatment.	Formaldehyde	118-130	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	71-90
23160383-9	2014	In addition, the activations of necrosis factor-kappaB (NF-kappaB) and activator protein 1 (AP-1) were induced by the formaldehyde treatment.	Formaldehyde	118-130	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	92-96
25323902-0	2014	Epidural dexamethasone decreased inflammatory hyperalgesia and spinal cPLA2 expression in a rat formalin test.	Formaldehyde	96-104	phospholipase A2 group IVA	Rattus norvegicus	70-75
25653835-0	2014	Application of ARID1A to murine formalin-fixed paraffin embedded tissue using immunohistochemistry.	Formaldehyde	32-40	AT rich interactive domain 1A (SWI-like)	Mus musculus	15-21
25653835-1	2014	ARID1A is a known suppressor of tumour formation and the Human Protein Atlas antibody HPA005456 has been demonstrated in previous literature to stain tumour tissue by immunohistochemistry (IHC) in formalin-fixed paraffin embedded human tissue and human cell lines.	Formaldehyde	197-205	AT-rich interaction domain 1A	Homo sapiens	0-6
25038272-3	2014	In this study we investigated Bcl-6 translocation and its transcriptional and translational levels in formalin-fixed, paraffin-embedded cerebral tissue sections from glioblastoma (GBM), low-grade glioma (Astrocytoma grade II and III), and meningioma patients, and correlated them with apoptotic processes and p53 and caspase-3 expression.	Formaldehyde	102-110	BCL6 transcription repressor	Homo sapiens	30-35
25550857-3	2014	Herein, we investigated the protein expression and the clinicopathological significance of IRAK1 in 3 formalin-fixed paraffin-embedded lung cancer tissue microarrays by using immunohistochemistry, which included 365 tumor and 30 normal lung tissues.	Formaldehyde	102-110	interleukin 1 receptor associated kinase 1	Homo sapiens	91-96
25139754-4	2014	Formalin-fixed paraffin-embedded tissue was used for immunocytochemical localization of Mphi, iNOS, and VEGF utilizing standard methodology.	Formaldehyde	0-8	nitric oxide synthase 2, inducible	Mus musculus	94-98
25139754-4	2014	Formalin-fixed paraffin-embedded tissue was used for immunocytochemical localization of Mphi, iNOS, and VEGF utilizing standard methodology.	Formaldehyde	0-8	vascular endothelial growth factor A	Mus musculus	104-108
24992176-0	2014	Delay to formalin fixation effect on HER2 test in breast cancer by dual-color silver-enhanced in situ hybridization (Dual-ISH).	Formaldehyde	9-17	erb-b2 receptor tyrosine kinase 2	Homo sapiens	37-41
25199759-5	2014	PIK3CA mutations were evaluated in formalin-fixed, paraffin-embedded tissues from core biopsies with a tumor cell content of &gt;= 20% by using classical Sanger sequencing of exon 9 and exon 20.	Formaldehyde	35-43	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	0-6
25239421-0	2014	Quantitative analysis of ERG expression and its splice isoforms in formalin-fixed, paraffin-embedded prostate cancer samples: association with seminal vesicle invasion and biochemical recurrence.	Formaldehyde	67-75	ETS transcription factor ERG	Homo sapiens	25-28
24992176-2	2014	One of the variables that negatively affects HER2 test is delay to formalin fixation (DFF).	Formaldehyde	67-75	erb-b2 receptor tyrosine kinase 2	Homo sapiens	45-49
24414131-2	2014	Here we examined the impact of formalin fixing conditions on HER2 immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) in xenografted tumor tissues.	Formaldehyde	31-39	erb-b2 receptor tyrosine kinase 2	Homo sapiens	61-65
24635731-7	2014	RESULTS: Fluorescence in situ hybridization screening of paraffin-embedded formalin-fixed tissue indeed revealed the presence of an MLL rearrangement.	Formaldehyde	75-83	lysine methyltransferase 2A	Homo sapiens	132-135
25838812-0	2014	HER-2 assessment in formalin-fixed paraffin-embedded breast cancer tissue by well-based reverse phase protein array.	Formaldehyde	20-28	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-5
25838812-6	2014	By well-based RPPA, we successfully detected HER-2 expression in 76 human breast formalin-fixed paraffin-embedded tissue samples.	Formaldehyde	81-89	erb-b2 receptor tyrosine kinase 2	Homo sapiens	45-50
24535833-6	2014	Evidence for a role of the PARP1 protein in melanoma ulceration and survival was investigated by testing gene expression levels taken from formalin-fixed paraffin-embedded tumors.	Formaldehyde	139-147	poly(ADP-ribose) polymerase 1	Homo sapiens	27-32
25090918-3	2014	Herein, we compare 2 alternative rabbit monoclonal antibodies (E17 and SP66) to the 124 clone in staining for BCL2 in formalin-fixed, paraffin-embedded DLBCL tissues.	Formaldehyde	118-126	BCL2 apoptosis regulator	Homo sapiens	110-114
25109304-0	2014	Formaldehyde induces bone marrow toxicity in mice by inhibiting peroxiredoxin 2 expression.	Formaldehyde	0-12	peroxiredoxin 2	Mus musculus	64-79
25100844-9	2014	We show that inactivation with formaldehyde has an effect on early steps of viral replication as it reduces the ability of PV to bind to hPVR, decreases the sensitivity of PV to convert to 135S particles, and abolishes the infectivity of its viral RNA.	Formaldehyde	31-43	PVR cell adhesion molecule	Homo sapiens	137-141
24785186-10	2014	Evaluating miR-944 in 52 formalin-fixed paraffin-embedded SCC tissues revealed that miR-944 expression was associated with lymph node metastasis.	Formaldehyde	25-33	microRNA 944	Homo sapiens	11-18
24785186-10	2014	Evaluating miR-944 in 52 formalin-fixed paraffin-embedded SCC tissues revealed that miR-944 expression was associated with lymph node metastasis.	Formaldehyde	25-33	microRNA 944	Homo sapiens	84-91
25131264-0	2014	Repeated formaldehyde inhalation impaired olfactory function and changed SNAP25 proteins in olfactory bulb.	Formaldehyde	9-21	synaptosome associated protein 25	Rattus norvegicus	73-79
25131264-13	2014	CONCLUSION: Repeated formaldehyde exposure impaired olfactory function by disturbing SNAP25 protein in the OB.	Formaldehyde	21-33	synaptosome associated protein 25	Rattus norvegicus	85-91
25567595-2	2014	METHODS: CD123 expression was evaluated by EliVision immunohistochemical staining in formalin-fixed and paraffin-embedded tissues from 30 cases of Kikuchi"s disease, 5 cases of T cell lymphoma, 10 cases of reactive lymphoid hyperplasia and 10 cases of chronic tonsillitis.	Formaldehyde	85-93	interleukin 3 receptor subunit alpha	Homo sapiens	9-14
25073108-1	2014	In 2012 the Committee for Risk Assessment (RAC) of the European Chemicals Agency concluded that 2ppm formaldehyde represent a Lowest Observed Adverse Effect Concentration (LOAEC) for polypoid adenomas, histopathological lesions and cell proliferation.	Formaldehyde	101-113	AKT serine/threonine kinase 1	Homo sapiens	26-47
25218890-3	2014	EndoPredict is a quantitative reverse transcription PCR assay conducted on RNA from formalin-fixed, paraffin-embedded (FFPE) tissue that predicts the likelihood of distant recurrence in patients with ER-positive/HER2-negative breast cancer.	Formaldehyde	84-92	erb-b2 receptor tyrosine kinase 2	Homo sapiens	212-216
25264680-0	2014	Aberrant production of Th1/Th2/Th17-related cytokines in serum of C57BL/6 mice after short-term formaldehyde exposure.	Formaldehyde	96-108	negative elongation factor complex member C/D, Th1l	Mus musculus	23-26
25118282-9	2014	Cat-S and PAR2 antagonists suppressed formalin-induced inflammation and pain, which implicates endogenous Cat-S and PAR2 in inflammatory pain.	Formaldehyde	38-46	cathepsin S	Mus musculus	0-5
25118282-9	2014	Cat-S and PAR2 antagonists suppressed formalin-induced inflammation and pain, which implicates endogenous Cat-S and PAR2 in inflammatory pain.	Formaldehyde	38-46	coagulation factor II (thrombin) receptor-like 1	Mus musculus	10-14
25118282-9	2014	Cat-S and PAR2 antagonists suppressed formalin-induced inflammation and pain, which implicates endogenous Cat-S and PAR2 in inflammatory pain.	Formaldehyde	38-46	cathepsin S	Mus musculus	106-111
25118282-9	2014	Cat-S and PAR2 antagonists suppressed formalin-induced inflammation and pain, which implicates endogenous Cat-S and PAR2 in inflammatory pain.	Formaldehyde	38-46	coagulation factor II (thrombin) receptor-like 1	Mus musculus	116-120
25264680-0	2014	Aberrant production of Th1/Th2/Th17-related cytokines in serum of C57BL/6 mice after short-term formaldehyde exposure.	Formaldehyde	96-108	heart and neural crest derivatives expressed 2	Mus musculus	27-30
25400755-0	2014	Quantitative RT-PCR assay of HER2 mRNA expression in formalin-fixed and paraffin-embedded breast cancer tissues.	Formaldehyde	53-61	erb-b2 receptor tyrosine kinase 2	Homo sapiens	29-33
25093854-1	2014	The potential energy surfaces (PES) for the SO3:H2CO and (SO3)2:H2CO complexes were thoroughly examined at the MP2/aug-cc-pVDZ computational level.	Formaldehyde	64-68	tryptase pseudogene 1	Homo sapiens	111-114
25400755-6	2014	Here we employed a quantitative PCR method to detect HER2 expression in one hundred ninety nine formalin-fixed and paraffin-embedded (FFPE) breast cancer tissue samples from the patients treated over two years at the Yonsei University Severance Hospital, Republic of Korea.	Formaldehyde	96-104	erb-b2 receptor tyrosine kinase 2	Homo sapiens	53-57
24997964-3	2014	While CH2O+HBr+O3, BrCHO+OH+HO2 and CH2O+Br+HO3 will be competitive to a certain extent in the atmosphere.	Formaldehyde	36-40	histidyl-tRNA synthetase 2, mitochondrial	Homo sapiens	44-47
24877687-0	2014	Inhibition of peripheral anion exchanger 3 decreases formalin-induced pain.	Formaldehyde	53-61	solute carrier family 4 member 3	Rattus norvegicus	25-42
24877687-1	2014	We determined the role of chloride-bicarbonate anion exchanger 3 in formalin-induced acute and chronic rat nociception.	Formaldehyde	68-76	solute carrier family 4 member 3	Rattus norvegicus	47-64
24877687-7	2014	Furthermore, Western blot analysis revealed a band of about 85 kDa indicative of anion exchanger 3 protein expression in dorsal root ganglia of naive rats, which was enhanced at 1 and 6 days after 1% formalin injection.	Formaldehyde	200-208	solute carrier family 4 member 3	Rattus norvegicus	81-98
24877687-9	2014	These results suggest that anion exchanger 3 is present in dorsal root ganglia and participates in the development and maintenance of short and long-lasting formalin-induced nociception.	Formaldehyde	157-165	solute carrier family 4 member 3	Rattus norvegicus	27-44
25184332-5	2014	Formalin injection caused a similar duration of licking in male Nf1+/- and wild type mice.	Formaldehyde	0-8	neurofibromin 1	Mus musculus	64-67
25125622-8	2014	CONCLUSIONS: Concomitant staining on formalin fixation of IIF-positive ethanol-fixed ANCA samples improves the interpretation of ANCA testing and is predictive of vasculitis autoantigens MPO and PR3.	Formaldehyde	37-45	myeloperoxidase	Homo sapiens	187-190
25125622-8	2014	CONCLUSIONS: Concomitant staining on formalin fixation of IIF-positive ethanol-fixed ANCA samples improves the interpretation of ANCA testing and is predictive of vasculitis autoantigens MPO and PR3.	Formaldehyde	37-45	proteinase 3	Homo sapiens	195-198
25203299-6	2014	We developed a novel RNA in situ hybridization-based assay for the in situ detection of ETV1, ETV4, and ETV5 in formalin-fixed paraffin-embedded tissues from prostate needle biopsies, prostatectomy, and metastatic PCa specimens using RNA probes.	Formaldehyde	112-120	ETS variant transcription factor 1	Homo sapiens	88-92
25203299-6	2014	We developed a novel RNA in situ hybridization-based assay for the in situ detection of ETV1, ETV4, and ETV5 in formalin-fixed paraffin-embedded tissues from prostate needle biopsies, prostatectomy, and metastatic PCa specimens using RNA probes.	Formaldehyde	112-120	ETS variant transcription factor 5	Homo sapiens	104-108
25036442-1	2014	In this study we determined the role of Ca(2+)-activated chloride channels (CaCC) in acute and chronic nociceptive responses elicited by 1% formalin.	Formaldehyde	140-148	chloride channel accessory 1	Homo sapiens	76-80
25036442-4	2014	Local peripheral and intrathecal pre-treatment (-10 min) with the non-selective and selective CaCC blockers niflumic acid and CaCCinh-A01, respectively, prevented formalin-induced flinching behavior mainly during phase 2 of the formalin test.	Formaldehyde	163-171	chloride channel accessory 1	Homo sapiens	94-98
25036442-4	2014	Local peripheral and intrathecal pre-treatment (-10 min) with the non-selective and selective CaCC blockers niflumic acid and CaCCinh-A01, respectively, prevented formalin-induced flinching behavior mainly during phase 2 of the formalin test.	Formaldehyde	228-236	chloride channel accessory 1	Homo sapiens	94-98
25036442-6	2014	Moreover, local peripheral and intrathecal post-treatment (on day 6) with both CaCC blockers decreased the established formalin-induced secondary mechanical allodynia and hyperalgesia behavior in both paws.	Formaldehyde	119-127	chloride channel accessory 1	Homo sapiens	79-83
25036442-8	2014	Formalin injection increased anoctamin-1, but not bestrophin-1 protein levels at 6 days.	Formaldehyde	0-8	anoctamin 1	Homo sapiens	29-40
25036442-9	2014	Intrathecal injection of the CaCC inhibitor CaCCinh-A01 prevented formalin-induced anoctamin-1 increase.	Formaldehyde	66-74	chloride channel accessory 1	Homo sapiens	29-33
25036442-9	2014	Intrathecal injection of the CaCC inhibitor CaCCinh-A01 prevented formalin-induced anoctamin-1 increase.	Formaldehyde	66-74	anoctamin 1	Homo sapiens	83-94
25036442-10	2014	Data suggest that peripheral and spinal CaCC, and particularly anoctamin-1, participates in the acute nociception induced by formalin as well as in the development and maintenance of secondary mechanical allodynia and hyperalgesia.	Formaldehyde	125-133	chloride channel accessory 1	Homo sapiens	40-44
25036442-10	2014	Data suggest that peripheral and spinal CaCC, and particularly anoctamin-1, participates in the acute nociception induced by formalin as well as in the development and maintenance of secondary mechanical allodynia and hyperalgesia.	Formaldehyde	125-133	anoctamin 1	Homo sapiens	63-74
25036442-11	2014	Thus, CaCC activity contributes to neuronal excitability in the process of nociception induced by formalin.	Formaldehyde	98-106	chloride channel accessory 1	Homo sapiens	6-10
24212133-5	2014	Immunohistochemical analysis for DR4 and DR5 was carried out on formalin-fixed paraffin-embedded sections of skin tissues using avidin-biotin peroxidase method.	Formaldehyde	64-72	TNF receptor superfamily member 10a	Homo sapiens	33-36
24212133-5	2014	Immunohistochemical analysis for DR4 and DR5 was carried out on formalin-fixed paraffin-embedded sections of skin tissues using avidin-biotin peroxidase method.	Formaldehyde	64-72	TNF receptor superfamily member 10b	Homo sapiens	41-44
25337593-5	2014	L1CAM expression was evaluated by immunohistochemistry using fresh formalin-fixed paraffin-embedded tissue block of the patients.	Formaldehyde	67-75	L1 cell adhesion molecule	Homo sapiens	0-5
25033726-5	2014	We studied the expression of WT-1 in formalin-fixed, paraffin-embedded tumor sections from 77 cases of endometrial serous carcinoma.	Formaldehyde	37-45	WT1 transcription factor	Homo sapiens	29-33
24504073-0	2014	A novel approach for HLA-A typing in formalin-fixed paraffin-embedded-derived DNA.	Formaldehyde	37-45	major histocompatibility complex, class I, A	Homo sapiens	21-26
24891594-5	2014	Histolocalization of HA in formalin-fixed, paraffin-embedded tissue sections using biotin-TSG-6-DeltaHep-Fc resulted in hyaluronidase-sensitive staining patterns similar to those obtained with biotin-HABP, but with improved sensitivity.	Formaldehyde	27-35	TNF alpha induced protein 6	Homo sapiens	90-95
24928951-6	2014	Furthermore, TRK-130 ameliorated formalin-induced frequent urination at doses of higher than 0.01 mg/kg p.o.	Formaldehyde	33-41	neurotrophic receptor tyrosine kinase 1	Homo sapiens	13-16
25324870-0	2014	Characterization of allergic response induced by repeated dermal exposure of IL-4/Luc/CNS-1 transgenic mice to low dose formaldehyde.	Formaldehyde	120-132	interleukin 4	Mus musculus	77-81
25324870-0	2014	Characterization of allergic response induced by repeated dermal exposure of IL-4/Luc/CNS-1 transgenic mice to low dose formaldehyde.	Formaldehyde	120-132	conserved intergenic sequence 1	Mus musculus	86-91
24717977-8	2014	Immunohistochemical studies and in situ hybridization of formalin fixed and paraffin embedded sections of human late term placenta showed expression of SOAT in syncytiotrophoblasts, predominantly at the apical membrane as well as in the vessel endothelium.	Formaldehyde	57-65	solute carrier family 10 member 6	Homo sapiens	152-156
24504073-6	2014	In this study, we amplified the most polymorphic exons of the HLA-A gene, exons 2, 3, and 4, in 16 formalin-fixed paraffin-embedded samples &gt;10 years old.	Formaldehyde	99-107	major histocompatibility complex, class I, A	Homo sapiens	62-67
24955867-3	2014	The present study investigated the interaction between the opioidergic and dopaminergic systems in the dorsal hippocampus (CA1) region for formalin-induced orofacial pain.	Formaldehyde	139-147	carbonic anhydrase 1	Rattus norvegicus	123-126
24718557-7	2014	During noxious information transmission induced by formalin plantar injection, GABAergic neurons expressing FOS in their nuclei were contacted with EM2- or SP-immunoreactive terminals.	Formaldehyde	51-59	tachykinin 1	Mus musculus	156-158
24931479-4	2014	Several HCOH families possess only four TMHs that exhibit the most pronounced similarity to the last four TMHs (TMHs 9-12) of HCOs/NORs.	Formaldehyde	8-12	LHFPL tetraspan subfamily member 5	Homo sapiens	40-44
24931479-4	2014	Several HCOH families possess only four TMHs that exhibit the most pronounced similarity to the last four TMHs (TMHs 9-12) of HCOs/NORs.	Formaldehyde	8-12	LHFPL tetraspan subfamily member 5	Homo sapiens	106-110
24931479-4	2014	Several HCOH families possess only four TMHs that exhibit the most pronounced similarity to the last four TMHs (TMHs 9-12) of HCOs/NORs.	Formaldehyde	8-12	LHFPL tetraspan subfamily member 5	Homo sapiens	106-110
24931479-7	2014	The remaining HCOH families, including NnrS, have 12-TMHs and three EUs.	Formaldehyde	14-18	LHFPL tetraspan subfamily member 5	Homo sapiens	53-57
24249219-0	2014	Progesterone receptor isoform analysis by quantitative real-time polymerase chain reaction in formalin-fixed, paraffin-embedded canine mammary dysplasias and tumors.	Formaldehyde	94-102	progesterone receptor	Canis lupus familiaris	0-21
25210474-7	2014	Endothelin-1 directly activates nociceptors and potentiates the effect of other algogens, including capsaicin, formalin, and arachidonic acid.	Formaldehyde	111-119	endothelin 1	Homo sapiens	0-12
25159205-4	2014	METHODS: TERT promoter mutation analysis on fresh tumor DNA and DNA from formalin-fixed, paraffin-embedded specimens was performed by SNaPshot analysis in 102 uveal melanomas, 39 conjunctival melanomas, 26 PAM with atypia, 14 PAM without atypia, and 56 conjunctival nevi.	Formaldehyde	73-81	telomerase reverse transcriptase	Homo sapiens	9-13
25163478-6	2014	Further, acetaldehyde- and formalin-induced nociceptive behavior was greater in the ALDH2*1/*2 mice than in the wild-type mice.	Formaldehyde	27-35	aldehyde dehydrogenase 2, mitochondrial	Mus musculus	84-89
24249219-3	2014	This study analyzed progesterone receptor and its isoforms in formalin-fixed, paraffin-embedded tissue samples from canine mammary lesions (4 dysplasias, 10 benign tumors, and 46 carcinomas) using 1-step SYBR Green quantitative real-time polymerase chain reaction (RT-qPCR).	Formaldehyde	62-70	progesterone receptor	Canis lupus familiaris	20-41
24249219-10	2014	Analysis of progesterone receptor mRNA isoforms by RT-qPCR was successful in routinely formalin-fixed, paraffin-embedded tissue samples and enabled the distribution of isoforms A and B to be identified for the first time in dysplasias, benign tumors, and malignant tumors of the canine mammary gland.	Formaldehyde	87-95	progesterone receptor	Canis lupus familiaris	12-33
25133605-0	2014	Increased sensitivity to inflammatory pain induced by subcutaneous formalin injection in serine racemase knock-out mice.	Formaldehyde	67-75	serine racemase	Mus musculus	89-104
25055738-2	2014	Herein we describe the preparation of a novel nanospherical ordered mesoporous Lewis acid polymer (Sc(OTf)2-NSMP) by functionalizing the mesoporous phenol-formaldehyde polymer framework with scandium triflate groups.	Formaldehyde	155-167	POU class 2 homeobox 2	Homo sapiens	99-107
25337235-9	2014	Intrathecal administration of neuregulin-1beta 1 (NRG1-1), a 62 amino acid NRG1 mimetic, transiently increased paw withdrawal threshold in SNI model and reduced flinching in the formalin injection model.	Formaldehyde	178-186	neuregulin 1	Rattus norvegicus	50-56
25337235-9	2014	Intrathecal administration of neuregulin-1beta 1 (NRG1-1), a 62 amino acid NRG1 mimetic, transiently increased paw withdrawal threshold in SNI model and reduced flinching in the formalin injection model.	Formaldehyde	178-186	neuregulin 1	Rattus norvegicus	50-54
25068594-0	2014	Interaction between formaldehyde and luminescent MOF [Zn(NH2bdc)(bix)]n in the electronic excited state.	Formaldehyde	20-32	lysine acetyltransferase 8	Homo sapiens	49-52
25068594-1	2014	The hydrogen bond between formaldehyde and the luminescent metal-organic framework (MOF) [Zn(NH2bdc)(bix)]n was investigated using density functional theory and time-dependent density functional theory.	Formaldehyde	26-38	lysine acetyltransferase 8	Homo sapiens	59-88
25068594-4	2014	Strengthening of the hydrogen bond weakens the radioactive transition of [Zn(NH2bdc)(bix)]n, which thus leads to a luminescence decrease or quenching phenomenon, meaning that the luminescent MOF [Zn(NH2bdc)(bix)]n may be applied to the detection of formaldehyde.	Formaldehyde	249-261	lysine acetyltransferase 8	Homo sapiens	191-194
24749982-9	2014	Melagatran or PAR2 deletion suppressed oedema and mechanical hypersensitivity induced by intraplantar formalin, bradykinin and PAR2-AP, but had no effect on capsaicin-induced pain.	Formaldehyde	102-110	coagulation factor II (thrombin) receptor-like 1	Mus musculus	14-18
25076295-4	2014	DESIGN: Napsin A immunohistochemistry was performed using a rabbit polyclonal antibody on formalin-fixed, paraffin-embedded surgical and fine-needle aspiration biopsy-derived, paraffin-embedded cell block specimens.	Formaldehyde	90-98	napsin A aspartic peptidase	Homo sapiens	8-16
24215118-2	2014	MATERIAL AND METHODS: We studied the immunohistochemical expression and overexpression of EpCAM on TMAs containing formalin-fixed, paraffin-embedded samples of 948 patients with documented renal tumours.	Formaldehyde	115-123	epithelial cell adhesion molecule	Homo sapiens	90-95
24359286-5	2014	METHODS: We measured NRP2 gene expression in a panel of formalin-fixed paraffin-embedded tissue specimens consisting of naevi, primary melanomas and metastatic melanomas using quantitative reverse transcriptase-polymerase chain reaction technique.	Formaldehyde	56-64	neuropilin 2	Homo sapiens	21-25
23719484-5	2014	E-cadherin expression was evaluated by immunohistochemistry of formalin-fixed paraffin-embedded skin biopsies of foreign body granulomas (n = 21) and sarcoidosis (n = 21).	Formaldehyde	63-71	cadherin 1	Mus musculus	0-10
24749982-5	2014	KEY RESULTS: Intraplantar injection of formalin, bradykinin or PAR2-AP led to the activation of proteases that were susceptible to the serine protease inhibitor melagatran but resistant to soybean trypsin inhibitor (SBTI).	Formaldehyde	39-47	subtilisin-like protease C1	Glycine max	135-150
24749982-5	2014	KEY RESULTS: Intraplantar injection of formalin, bradykinin or PAR2-AP led to the activation of proteases that were susceptible to the serine protease inhibitor melagatran but resistant to soybean trypsin inhibitor (SBTI).	Formaldehyde	39-47	kunitz trypsin protease inhibitor	Glycine max	197-214
25070653-8	2014	Analysis of eIF3a expression in primary formalin-fixed paraffin embedded UBC samples of 198 patients revealed that eIF3a up-regulation corresponds to tumour grade and that high eIF3a expression corresponds to longer overall survival rates of patients with low grade tumours.	Formaldehyde	40-48	eukaryotic translation initiation factor 3 subunit J	Homo sapiens	12-17
25007965-6	2014	Antibodies against ERbeta variants were validated for staining specificity in cell lines by siRNA knockdown of ESR2 and staining reproducibility on formalin-fixed paraffin-embedded tissue by quantitative immunofluorescence (QIF) using AQUA technology.	Formaldehyde	148-156	estrogen receptor 2	Homo sapiens	19-25
25038392-5	2014	Intraplantar formalin injection produced a significant activation of p38 MAPK, as well as mitogen-activated kinase kinase (MKK) 3 and MKK6, its upstream activators, in the bilateral rACC.	Formaldehyde	13-21	mitogen activated protein kinase 14	Rattus norvegicus	69-72
25038392-5	2014	Intraplantar formalin injection produced a significant activation of p38 MAPK, as well as mitogen-activated kinase kinase (MKK) 3 and MKK6, its upstream activators, in the bilateral rACC.	Formaldehyde	13-21	mitogen-activated protein kinase kinase 6	Rattus norvegicus	134-138
24796717-0	2014	Inhibition of STAT6 during vaccination with formalin-inactivated RSV prevents induction of Th2-cell-biased airway disease.	Formaldehyde	44-52	signal transducer and activator of transcription 6	Mus musculus	14-19
24709436-4	2014	MGMT methylation status was assessed in formalin-fixed, paraffin-embedded tumor specimens by pyrosequencing.	Formaldehyde	40-48	O-6-methylguanine-DNA methyltransferase	Homo sapiens	0-4
25120063-4	2014	METHODS: Immunohistochemistry (IHC) was used to detect ARID3B expression in 63 formalin-fixed paraffin-embedded (FFPE) invasive breast cancer samples.	Formaldehyde	79-87	AT-rich interaction domain 3B	Homo sapiens	55-61
24796717-0	2014	Inhibition of STAT6 during vaccination with formalin-inactivated RSV prevents induction of Th2-cell-biased airway disease.	Formaldehyde	44-52	heart and neural crest derivatives expressed 2	Mus musculus	91-94
24796717-2	2014	Th2-cell-deviated responses have been implicated in both human and murine susceptibility to enhanced disease following formalin-inactivated (FI) vaccines for measles and RSV.	Formaldehyde	119-127	heart and neural crest derivatives expressed 2	Mus musculus	0-3
24842316-0	2014	Detection of MYD88 L265P mutations in formalin-fixed and decalcified BM biopsies from patients with lymphoplasmacytic lymphoma.	Formaldehyde	38-46	MYD88 innate immune signal transduction adaptor	Homo sapiens	13-18
24374727-4	2014	We used a multiplex protein assay to determine the tumor expression levels of the proangiogenic proteins IL-6, IL-8, bFGF, PDGF-BB and VEGF-A in formalin-fixed paraffin-embedded tumors from the MAX clinical trial patients with available tissue samples.	Formaldehyde	145-153	interleukin 6	Homo sapiens	105-109
24220877-5	2014	Expression of dehydrogenase (formaldehyde dehydrogenase (FDH)) in the formaldehyde (10.40) and methanol (10.60) groups increased significantly compared with the control (1), while it was similar to the control in formic acid (0.90) and acetaldehyde (1.10) groups.	Formaldehyde	29-41	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	57-60
24220877-7	2014	Exposure to formaldehyde changes the endogenous formaldehyde concentration in cells within 24 h, and this induces expression of FDH for formaldehyde degradation to maintain the formaldehyde balance.	Formaldehyde	12-24	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	128-131
24220877-7	2014	Exposure to formaldehyde changes the endogenous formaldehyde concentration in cells within 24 h, and this induces expression of FDH for formaldehyde degradation to maintain the formaldehyde balance.	Formaldehyde	48-60	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	128-131
24220877-7	2014	Exposure to formaldehyde changes the endogenous formaldehyde concentration in cells within 24 h, and this induces expression of FDH for formaldehyde degradation to maintain the formaldehyde balance.	Formaldehyde	48-60	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	128-131
24220877-7	2014	Exposure to formaldehyde changes the endogenous formaldehyde concentration in cells within 24 h, and this induces expression of FDH for formaldehyde degradation to maintain the formaldehyde balance.	Formaldehyde	48-60	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	128-131
24374727-4	2014	We used a multiplex protein assay to determine the tumor expression levels of the proangiogenic proteins IL-6, IL-8, bFGF, PDGF-BB and VEGF-A in formalin-fixed paraffin-embedded tumors from the MAX clinical trial patients with available tissue samples.	Formaldehyde	145-153	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
24374727-4	2014	We used a multiplex protein assay to determine the tumor expression levels of the proangiogenic proteins IL-6, IL-8, bFGF, PDGF-BB and VEGF-A in formalin-fixed paraffin-embedded tumors from the MAX clinical trial patients with available tissue samples.	Formaldehyde	145-153	fibroblast growth factor 2	Homo sapiens	117-121
24374727-4	2014	We used a multiplex protein assay to determine the tumor expression levels of the proangiogenic proteins IL-6, IL-8, bFGF, PDGF-BB and VEGF-A in formalin-fixed paraffin-embedded tumors from the MAX clinical trial patients with available tissue samples.	Formaldehyde	145-153	vascular endothelial growth factor A	Homo sapiens	135-141
24827824-2	2014	METHODS: ALDH1 immunohistochemistry was performed on formalin-fixed, paraffin wax-embedded cervical tumour tissue samples obtained from hospital archives.	Formaldehyde	53-61	aldehyde dehydrogenase 1 family member A1	Homo sapiens	9-14
24919811-3	2014	In the present study, the expression of Notch3 in HCC and adjacent non-neoplastic tissue was immunohistochemically assessed on formalin-fixed, paraffin-embedded sections.	Formaldehyde	127-135	notch receptor 3	Homo sapiens	40-46
24925603-5	2014	COX-2 protein was detected by immunohistochemistry in formalin-fixed, paraffin wax-embedded lung tissues from 10 pigs infected experimentally with Mh.	Formaldehyde	54-62	cytochrome c oxidase subunit II	Sus scrofa	0-5
24604154-5	2014	METHODS: We correlated pathologist-generated estimates of tumor cellularity versus mutant allele percentage via pyrosequencing as a QA measure for BRAF mutation detection in formalin-fixed, paraffin-embedded melanoma specimens.	Formaldehyde	174-182	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	147-151
24913732-7	2014	Secondly, we used branched DNA-liquidchip technology (bDNA-LCT) for detecting ASNS mRNA in formalin-fixed, paraffin-embedded tissue sections in 50 cases of NK/T cell lymphoma and in 12 cases of nasal polyps and chronic rhinitis.	Formaldehyde	91-99	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	78-82
24664550-0	2014	Highly sensitive KRAS mutation detection from formalin-fixed paraffin-embedded biopsies and circulating tumour cells using wild-type blocking polymerase chain reaction and Sanger sequencing.	Formaldehyde	46-54	KRAS proto-oncogene, GTPase	Homo sapiens	17-21
24977739-4	2014	We used a rabbit monoclonal STAT6 antibody (1:100), which has not been reported by others, on formalin fixed, paraffin embedded whole sections and tissue microarray slides.	Formaldehyde	94-102	signal transducer and activator of transcription 6	Homo sapiens	28-33
24793910-7	2014	Cleaved SNAP-25 in TNC disappeared after formalin-induced trigeminal ganglion ablation or capsaicin-induced sensory denervation.	Formaldehyde	41-49	synaptosome associated protein 25	Rattus norvegicus	8-15
24793910-8	2014	Occurrence of cleaved SNAP-25 in TNC and BoNT/A antinociceptive activity in formalin-induced orofacial pain were prevented by denervation with capsaicin.	Formaldehyde	76-84	synaptosome associated protein 25	Rattus norvegicus	22-29
24875296-4	2014	MATERIALS AND METHODS: We studied the immunohistochemical expression of c-kit on tissue microarrays containing formalin-fixed, paraffin-embedded samples of 948 patients with renal tumors.	Formaldehyde	111-119	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	72-77
24531883-1	2014	The binding within the ethene-argon and formaldehyde-methane complexes in the ground and electronically excited states is studied with equation of motion coupled cluster theory (EOM-CCSD), second-order Moller-Plesset perturbation theory (MP2) and density functional theory with dispersion corrections (DFT-D).	Formaldehyde	40-52	tryptase pseudogene 1	Homo sapiens	238-241
24872407-7	2014	Finally, knockdown of STX8 in rat dorsal root ganglia by recombinant adeno-associated virus serotype 6-mediated RNA interference led to analgesic effects on formalin-induced inflammatory pain.	Formaldehyde	157-165	syntaxin 8	Rattus norvegicus	22-26
25026998-3	2014	METHODS: Immunohistochemical staining for WT1 was performed in 87 cases of STS using formalin-fixed, paraffin-embedded blocks.	Formaldehyde	85-93	WT1 transcription factor	Homo sapiens	42-45
24858690-2	2014	DMGDH is a flavin containing enzyme which catalyzes the oxidative demethylation of dimethylglycine in vitro with the formation of sarcosine (N-methylglycine), hydrogen peroxide and formaldehyde.	Formaldehyde	181-193	dimethylglycine dehydrogenase	Rattus norvegicus	0-5
24858690-3	2014	DMGDH binds tetrahydrofolate (THF) in vivo, which serves as an acceptor of formaldehyde and in the cell the product of the reaction is 5,10-methylenetetrahydrofolate instead of formaldehyde.	Formaldehyde	75-87	dimethylglycine dehydrogenase	Rattus norvegicus	0-5
24858690-3	2014	DMGDH binds tetrahydrofolate (THF) in vivo, which serves as an acceptor of formaldehyde and in the cell the product of the reaction is 5,10-methylenetetrahydrofolate instead of formaldehyde.	Formaldehyde	177-189	dimethylglycine dehydrogenase	Rattus norvegicus	0-5
24914604-6	2014	The resorcinol-formaldehyde resins carbonized at 600 and 900  C demonstrate BET surface areas of 592.4 m(2)/g and 952.5 m(2)/g with specific capacitances of 17.5, and 33.5 F/g (scan rate of 5 mV/s), respectively.	Formaldehyde	15-27	delta/notch like EGF repeat containing	Homo sapiens	76-79
24877885-5	2014	Meanwhile, we performed reverse transcription-polymerase chain reaction (RT-PCR) to measure the expression of six microRNAs targeting ET-1 in formalin-fixed, paraffin-embedded coronary arteries.	Formaldehyde	142-150	endothelin 1	Homo sapiens	134-138
24926080-0	2014	The effects of under 6 hours of formalin fixation on hormone receptor and HER2 expression in invasive breast cancer: a systematic review.	Formaldehyde	32-40	erb-b2 receptor tyrosine kinase 2	Homo sapiens	74-78
24926080-1	2014	OBJECTIVES: A systematic review of the literature was performed to identify whether minimum formalin fixation time may be reduced for reliable immunohistochemical assessment of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2).	Formaldehyde	92-100	estrogen receptor 1	Homo sapiens	177-194
23958544-4	2014	We performed immunohistochemical analysis for GRPR on formalin-fixed and paraffin-embedded tumor samples obtained from 35 patients with anal cancer.	Formaldehyde	54-62	gastrin releasing peptide receptor	Homo sapiens	46-50
24129596-2	2014	Electrophysiological studies of the spinal cord have demonstrated that 5-HT3R is involved in nociception induced by intraplantar injection of formalin, but not carrageenan.	Formaldehyde	142-150	5-hydroxytryptamine receptor 3A	Rattus norvegicus	71-77
24998930-3	2014	Here, we identify the metalloprotease Wss1 as being crucial for cell survival upon exposure to formaldehyde and topoisomerase 1-dependent DNA damage.	Formaldehyde	95-107	metalloendopeptidase WSS1	Saccharomyces cerevisiae S288C	38-42
24680883-5	2014	Topical application of the TRPV1 receptor antagonist capsazepine onto the spinal cord inhibited the induction of spinal LTP by CFA or formalin.	Formaldehyde	134-142	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	27-32
25118725-14	2014	CONCLUSION: Calretinin is a reliable single immune marker for ruling out HD by its specific positive mucosal staining of formalin fixed rectal biopsy.	Formaldehyde	121-129	calbindin 2	Homo sapiens	12-22
24242293-0	2014	A standardized staining protocol for L1CAM on formalin-fixed, paraffin-embedded tissues using automated platforms.	Formaldehyde	46-54	L1 cell adhesion molecule	Homo sapiens	37-42
26150933-0	2014	Determining methylation status of methylguanine DNA methyl transferase (MGMT) from formalin-fixed, paraffin embedded tumor tissue.	Formaldehyde	83-91	O-6-methylguanine-DNA methyltransferase	Homo sapiens	34-70
26150933-0	2014	Determining methylation status of methylguanine DNA methyl transferase (MGMT) from formalin-fixed, paraffin embedded tumor tissue.	Formaldehyde	83-91	O-6-methylguanine-DNA methyltransferase	Homo sapiens	72-76
25494138-4	2014	Aim: In this research work, the over expression of EGFR in formalin fixed paraffin-embedded (FFPE) colorectal cancer tumor tissue of patients was studied.	Formaldehyde	59-67	epidermal growth factor receptor	Homo sapiens	51-55
24715612-4	2014	This reaction is similar to those performed by dimethylglycine dehydrogenase and sarcosine dehydrogenase, in which protein-bound tetrahydrofolate (THF) was proposed to serve as an acceptor of the generated formaldehyde.	Formaldehyde	206-218	sarcosine dehydrogenase	Homo sapiens	81-104
25120807-0	2014	Association between mir-24 and mir-378 in formalin-fixed paraffin-embedded tissues of breast cancer.	Formaldehyde	42-50	microRNA 378a	Homo sapiens	31-38
24483941-2	2014	MnSOD expression was analyzed immunohistochemically in 48 formalin-fixed and paraffin-embedded specimens from patients with UC who had undergone endoscopical biopsy.	Formaldehyde	58-66	superoxide dismutase 2	Homo sapiens	0-5
24889502-4	2014	We developed and validated a new real-time quantitative polymerase chain reaction (PCR) assay for single-step detection of IDH1 R132H and 11 rare IDH1/2 mutations in formalin-fixed paraffin-embedded (FFPE) glioma samples.	Formaldehyde	166-174	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	146-152
24588324-4	2014	METHODS: In this study, polymerase chain reaction and direct sequencing of TERT promoter using formalin-fixed and paraffin-embedded tissue was performed to investigate whether these UV-signature mutations were also present in acral lentiginous melanoma.	Formaldehyde	95-103	telomerase reverse transcriptase	Homo sapiens	75-79
24461457-0	2014	72-gene classifier for predicting prognosis of estrogen receptor-positive and node-negative breast cancer patients using formalin-fixed, paraffin-embedded tumor tissues.	Formaldehyde	121-129	estrogen receptor 1	Homo sapiens	47-64
24985170-1	2014	OBJECTIVE: To explore the feasibility of detecting lymphoma with the application of BIOMED-2 standardized immunoglobulin/T cell receptor (IG/TCR) gene rearrangement system in formalin fixed paraffin-embedded (FFPE) tissue samples, and to discuss the relationship between the longest amplification fragment of extracted DNA and positive detection rate of different IGH V-J primers.	Formaldehyde	175-183	immunoglobulin heavy locus	Homo sapiens	364-367
24202438-6	2014	Immunohistochemistry for MMP-1 was performed on formalin-fixed and paraffin-embedded sections.	Formaldehyde	48-56	matrix metallopeptidase 1	Homo sapiens	25-30
22891713-3	2014	The c.1430G&gt;T mutation in c-KIT exon 9 was detected in 15.7% (11 of 70) of samples by mutant-specific PCR but in only 7.1% (5 of 70) by PCR-restriction fragment length polymorphism (RFLP) in the genomic DNA isolated from 70 formalin-fixed paraffin-embedded sections or cells collected by fine needle aspiration.	Formaldehyde	227-235	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	29-34
24878577-0	2014	Altered formalin-induced pain and Fos induction in the periaqueductal grey of preadolescent rats following neonatal LPS exposure.	Formaldehyde	8-16	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	34-37
25169219-0	2014	[Role of PARP-1 in formaldehyde-induced DNA damage repair and apoptosis in human bronchial epithelial cells].	Formaldehyde	19-31	poly(ADP-ribose) polymerase 1	Homo sapiens	9-15
25169219-1	2014	OBJECTIVE: To study the role of poly (ADP-ribose) polymerase-l (PARP-1) in formaldehyde-induced DNA damage response in human bronchial epithelial (HBE) cells and to investigate the mechanism of formaldehyde carcinogenicity.	Formaldehyde	75-87	poly(ADP-ribose) polymerase 1	Homo sapiens	64-70
25169219-1	2014	OBJECTIVE: To study the role of poly (ADP-ribose) polymerase-l (PARP-1) in formaldehyde-induced DNA damage response in human bronchial epithelial (HBE) cells and to investigate the mechanism of formaldehyde carcinogenicity.	Formaldehyde	194-206	poly(ADP-ribose) polymerase 1	Homo sapiens	64-70
25169219-7	2014	The 10 micromol/L formaldehyde resulted in significant increases in the protein levels of PARP-1 and XRCC-1.	Formaldehyde	18-30	poly(ADP-ribose) polymerase 1	Homo sapiens	90-96
25169219-7	2014	The 10 micromol/L formaldehyde resulted in significant increases in the protein levels of PARP-1 and XRCC-1.	Formaldehyde	18-30	X-ray repair cross complementing 1	Homo sapiens	101-107
25169219-8	2014	However, 80 micromol/L formaldehyde led to a significant decrease in the protein level of PARP-1 of 124 KD molecular weight but a significant increase in the protein level of PARP-1 of 89 KD molecular weight; there was no significant change in the protein level of XRCC-1.	Formaldehyde	23-35	poly(ADP-ribose) polymerase 1	Homo sapiens	90-96
25169219-8	2014	However, 80 micromol/L formaldehyde led to a significant decrease in the protein level of PARP-1 of 124 KD molecular weight but a significant increase in the protein level of PARP-1 of 89 KD molecular weight; there was no significant change in the protein level of XRCC-1.	Formaldehyde	23-35	poly(ADP-ribose) polymerase 1	Homo sapiens	175-181
25169219-8	2014	However, 80 micromol/L formaldehyde led to a significant decrease in the protein level of PARP-1 of 124 KD molecular weight but a significant increase in the protein level of PARP-1 of 89 KD molecular weight; there was no significant change in the protein level of XRCC-1.	Formaldehyde	23-35	X-ray repair cross complementing 1	Homo sapiens	265-271
25169219-9	2014	The co-immunoprecipitation assay showed that 10 micromol/L formaldehyde induced increased binding between PARP-1 and XRCC-1, but 80 micromol/L formaldehyde led to no significant change in binding between PARP-1 and XRCC-1.	Formaldehyde	59-71	poly(ADP-ribose) polymerase 1	Homo sapiens	106-112
25169219-9	2014	The co-immunoprecipitation assay showed that 10 micromol/L formaldehyde induced increased binding between PARP-1 and XRCC-1, but 80 micromol/L formaldehyde led to no significant change in binding between PARP-1 and XRCC-1.	Formaldehyde	59-71	X-ray repair cross complementing 1	Homo sapiens	117-123
25169219-9	2014	The co-immunoprecipitation assay showed that 10 micromol/L formaldehyde induced increased binding between PARP-1 and XRCC-1, but 80 micromol/L formaldehyde led to no significant change in binding between PARP-1 and XRCC-1.	Formaldehyde	59-71	poly(ADP-ribose) polymerase 1	Homo sapiens	204-210
25169219-9	2014	The co-immunoprecipitation assay showed that 10 micromol/L formaldehyde induced increased binding between PARP-1 and XRCC-1, but 80 micromol/L formaldehyde led to no significant change in binding between PARP-1 and XRCC-1.	Formaldehyde	59-71	X-ray repair cross complementing 1	Homo sapiens	215-221
25169219-12	2014	Moreover, compared with control, inhibition of PARP-1 induced a significant increase in tail DNA content, and a significant difference was observed in tail DNA content between inhibited HBE cells and control cells at 2 h after formaldehyde was removed.	Formaldehyde	227-239	poly(ADP-ribose) polymerase 1	Homo sapiens	47-53
25169219-14	2014	CONCLUSION: PARP-1 mediated the repair of DNA damage induced by low-concentration formaldehyde through recruiting XRCC-1 protein, and may be involved in the regulation of cell apoptosis induced by high-concentration formaldehyde.	Formaldehyde	82-94	poly(ADP-ribose) polymerase 1	Homo sapiens	12-18
25169219-14	2014	CONCLUSION: PARP-1 mediated the repair of DNA damage induced by low-concentration formaldehyde through recruiting XRCC-1 protein, and may be involved in the regulation of cell apoptosis induced by high-concentration formaldehyde.	Formaldehyde	82-94	X-ray repair cross complementing 1	Homo sapiens	114-120
25169219-14	2014	CONCLUSION: PARP-1 mediated the repair of DNA damage induced by low-concentration formaldehyde through recruiting XRCC-1 protein, and may be involved in the regulation of cell apoptosis induced by high-concentration formaldehyde.	Formaldehyde	216-228	poly(ADP-ribose) polymerase 1	Homo sapiens	12-18
24878577-5	2014	Formalin injections were associated with increased Fos-protein labelling in lateral habenula (LHb) as compared to medial habenula (MHb), however the intensity of this labelling did not differ as a result of neonatal immune challenge.	Formaldehyde	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	51-54
24883046-0	2014	Assessment of vascular endothelial growth factor in formalin fixed, paraffin embedded colon cancer specimens by means of a well-based reverse phase protein array.	Formaldehyde	52-60	vascular endothelial growth factor A	Homo sapiens	14-48
24870408-6	2014	METHODS: Tumour CD26 expression levels were studied by immunohistochemistry using Formalin-fixed paraffin embedded (FFPE) tissues in 143 patients with CRC.	Formaldehyde	82-90	dipeptidyl peptidase 4	Homo sapiens	16-20
24833884-3	2014	The expression of Bmi-1 and PAI-1 was examined immunohistochemically in formalin-fixed paraffin-embedded primary tissue specimens.	Formaldehyde	72-80	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	18-23
24833884-3	2014	The expression of Bmi-1 and PAI-1 was examined immunohistochemically in formalin-fixed paraffin-embedded primary tissue specimens.	Formaldehyde	72-80	serpin family E member 1	Homo sapiens	28-33
24883046-6	2014	Protein lysates derived from formalin fixed, paraffin embedded tissue contained measurable immunoreactive VEGF molecules.	Formaldehyde	29-37	vascular endothelial growth factor A	Homo sapiens	106-110
24614655-3	2014	We previously reported that Card9(-/-) mice vaccinated with formalin-killed spherules failed to acquire resistance to Coccidioides infection.	Formaldehyde	60-68	caspase recruitment domain family, member 9	Mus musculus	28-33
24464080-5	2014	Quantitative real-time PCR analyses and enzyme activity analyses demonstrated that glutathione-dependent formaldehyde dehydrogenase (GDFADH) and formate dehydrogenase (FDH) pathway may play a functional role in enhancing formaldehyde-degrading capability in SGFA1.	Formaldehyde	105-117	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	133-139
24464080-5	2014	Quantitative real-time PCR analyses and enzyme activity analyses demonstrated that glutathione-dependent formaldehyde dehydrogenase (GDFADH) and formate dehydrogenase (FDH) pathway may play a functional role in enhancing formaldehyde-degrading capability in SGFA1.	Formaldehyde	105-117	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	168-171
24766482-3	2014	The MP2 results indicate that the three stationary points of (CH2S)2 and four of CH2O/CH2S are minima, in contrast to two stationary points of the formaldehyde dimer, (CH2O)2.	Formaldehyde	81-85	tryptase pseudogene 1	Homo sapiens	4-7
24702591-1	2014	Efficient Rh(II)-catalyzed three-component reactions of 3-diazooxindoles and formaldehyde with either anilines or water were developed to give a series of substituted 3-amino-3-hydroxymethyloxindoles or 3-hydroxy-3-hydroxymethyloxindoles in good to excellent yields.	Formaldehyde	77-89	Rh blood group D antigen	Homo sapiens	10-17
24606013-0	2014	Expression level of miR-93 in formalin-fixed paraffin-embedded tissues of breast cancer patients.	Formaldehyde	30-38	microRNA 9-3	Homo sapiens	20-26
24606013-2	2014	The objective of this study was to evaluate the potential predictive value of miR-93 expression in formalin-fixed paraffin-embedded (FFPE) tissues of breast cancer patients.	Formaldehyde	99-107	microRNA 9-3	Homo sapiens	78-84
24227542-3	2014	Immunohistochemistry for RECK protein was performed on formalin fixed and paraffin-embedded sections.	Formaldehyde	55-63	reversion inducing cysteine rich protein with kazal motifs	Homo sapiens	25-29
24384038-0	2014	Effects of the selective sigma-1 receptor antagonist S1RA on formalin-induced pain behavior and neurotransmitter release in the spinal cord in rats.	Formaldehyde	61-69	sigma non-opioid intracellular receptor 1	Rattus norvegicus	25-41
24384038-9	2014	The selective sigma1 receptor antagonist S1RA results in inhibition of formalin-evoked Glu release, no modification of GABA levels, and enhancement of noradrenaline (NA) levels.	Formaldehyde	71-79	sigma non-opioid intracellular receptor 1	Rattus norvegicus	14-29
24524846-5	2014	Second, in mouse pain models using formalin and complete Freund adjuvant, we found that acupuncture attenuated the nociceptive behavior and the mechanical allodynia; these effects were blocked when ERK cascade was interrupted by the mitogen-activated protein kinase kinase (MEK)/mitogen-activated protein kinase (MAPK) inhibitor U0126 (.8 mug/muL).	Formaldehyde	35-43	mitogen-activated protein kinase 1	Mus musculus	198-201
24517902-6	2014	5-HT- or 5-CT-induced antinociception in the formalin test was diminished by the selective 5-HT5A receptor antagonist N-[2-(dimethylamino)ethyl]-N-[[4"-[[(2-phenylethyl)amino] methyl][1,1"-biphenyl]-4-yl]methyl]cyclopentanepropanamide dihydrochloride (SB-699551; 3 and 10 nmol).	Formaldehyde	45-53	5-hydroxytryptamine receptor 5A	Rattus norvegicus	91-97
24517902-9	2014	5-HT5A receptors were expressed in the dorsal spinal cord and DRG, even though formalin injection increased after 24h 5-HT5A receptor expression only in the spinal cord.	Formaldehyde	79-87	5-hydroxytryptamine receptor 5A	Rattus norvegicus	118-124
24122631-3	2014	The aim of this study is to investigate if miR-21 expression from RNA isolated from formalin-fixed paraffin-embedded (FFPE) tissue sections is associated with prognosis and therapeutic outcome for patients with CC.	Formaldehyde	84-92	microRNA 21	Homo sapiens	43-49
24552495-6	2014	The tissue-specific impact of the CPR loss in IECN and LCN mice on microsomal AOM metabolic activity was confirmed by rates of formation of formaldehyde and N(7)-mG in vitro.	Formaldehyde	140-152	cytochrome p450 oxidoreductase	Mus musculus	34-37
24719110-3	2014	In addition, intrathecal GLP-1R agonists GLP-1(7-36) and exenatide potently alleviated formalin-, peripheral nerve injury-, bone cancer-, and diabetes-induced hypersensitivity states by 60-90%, without affecting acute nociceptive responses.	Formaldehyde	87-95	glucagon-like peptide 1 receptor	Rattus norvegicus	25-31
24722772-4	2014	METHODOLOGY/PRINCIPAL FINDINGS: The overall mobility of the DNA damage sensors UV-DDB (ultraviolet-damaged DNA-binding) and XPC (xeroderma pigmentosum group C) was analyzed by assessing real-time protein dynamics in the nucleus of cultured human cells exposed to non-cytotoxic (&lt;100 muM) formaldehyde concentrations.	Formaldehyde	291-303	XPC complex subunit, DNA damage recognition and repair factor	Homo sapiens	129-158
24719110-3	2014	In addition, intrathecal GLP-1R agonists GLP-1(7-36) and exenatide potently alleviated formalin-, peripheral nerve injury-, bone cancer-, and diabetes-induced hypersensitivity states by 60-90%, without affecting acute nociceptive responses.	Formaldehyde	87-95	glucagon	Rattus norvegicus	25-30
24464231-5	2014	Here we describe a newly developed monoclonal antibody binding to the C-terminus of neurofibromin (clone NFC) which was selected for optimal performance in routinely processed formalin-fixed and paraffin-embedded tissue.	Formaldehyde	176-184	neurofibromin 1	Homo sapiens	84-97
24632205-6	2014	Furthermore, formaldehyde-assisted isolation of regulatory elements (FAIRE)-quantitative polymerase chain reaction (qPCR) experiments showed that depletion of FLII resulted in reduced chromatin accessibility of multiple ERalpha target genes.	Formaldehyde	13-25	FLII actin remodeling protein	Homo sapiens	159-163
24632205-6	2014	Furthermore, formaldehyde-assisted isolation of regulatory elements (FAIRE)-quantitative polymerase chain reaction (qPCR) experiments showed that depletion of FLII resulted in reduced chromatin accessibility of multiple ERalpha target genes.	Formaldehyde	13-25	estrogen receptor 1	Homo sapiens	220-227
24698267-8	2014	Finally, let-7b can be released from DRG neurons by neuronal activation, and let-7b inhibitor reduces formalin-induced TRPA1 currents and spontaneous pain.	Formaldehyde	102-110	microRNA let-7b	Homo sapiens	9-15
24698267-8	2014	Finally, let-7b can be released from DRG neurons by neuronal activation, and let-7b inhibitor reduces formalin-induced TRPA1 currents and spontaneous pain.	Formaldehyde	102-110	microRNA let-7b	Homo sapiens	77-83
24698267-8	2014	Finally, let-7b can be released from DRG neurons by neuronal activation, and let-7b inhibitor reduces formalin-induced TRPA1 currents and spontaneous pain.	Formaldehyde	102-110	transient receptor potential cation channel subfamily A member 1	Homo sapiens	119-124
24210682-5	2014	We demonstrate that orally administered BCP reduced inflammatory (late phase) pain responses in the formalin test in a CB2 receptor-dependent manner, while it had no effect on acute (early phase) responses.	Formaldehyde	100-108	opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan)	Mus musculus	40-43
23928652-6	2014	RESULTS: Subcutaneous and intrathecal DAAO inhibitors, including 5-chloro-benzo[d]isoxazol-3-ol, AS057278, and sodium benzoate, completely prevented and reversed morphine antinociceptive tolerance in the formalin, hot-plate, and tail-immersion tests, with a positive correlation to their DAAO inhibitory activities.	Formaldehyde	204-212	D-amino-acid oxidase	Rattus norvegicus	38-42
24412800-7	2014	In addition, acupuncture at ST36 and/or upper lip formalin induced c-Fos expression in the nucleus accumbens and in rostral ventral medulla.	Formaldehyde	50-58	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	67-72
24491355-4	2014	A combined analysis of immunohistochemistry and fluorescence in situ hybridization revealed ERBB2-amplified cancer cells in 51 of 475 formalin-fixed, paraffin-embedded gastric adenocarcinomas.	Formaldehyde	134-142	erb-b2 receptor tyrosine kinase 2	Homo sapiens	92-97
24659264-5	2014	We compared the expression level of miR-23a in DLBCL patients (n = 104) and reactive lymph nodes as controls (n = 28) from formalin-fixed, paraffin-embedded tissues using quantitative reverse transcription-polymerase chain reaction.	Formaldehyde	123-131	microRNA 23a	Homo sapiens	36-43
24057116-5	2014	NRG-1 inhibits neuropathic pain after SNI in a dose-dependent manner, while NRG-1 aggravates formalin-induced neuropathic pain.	Formaldehyde	93-101	neuregulin 1	Homo sapiens	76-81
24051693-10	2014	Furthermore, miR-31 is universally expressed in both ulcerative colitis and Crohn disease not only in fresh-frozen but also in formalin-fixed, paraffin-embedded tissues.	Formaldehyde	127-135	microRNA 31	Homo sapiens	13-19
24057116-7	2014	Knockdown of ErbB2 relieves the aggravation of NRG-1 on formalin-induced neuropathic pain, and knockdown of ErbB4 could relieve the inhibition of NRG-1 on neuropathic pain in the SNI model.	Formaldehyde	56-64	erb-b2 receptor tyrosine kinase 2	Homo sapiens	13-18
24057116-7	2014	Knockdown of ErbB2 relieves the aggravation of NRG-1 on formalin-induced neuropathic pain, and knockdown of ErbB4 could relieve the inhibition of NRG-1 on neuropathic pain in the SNI model.	Formaldehyde	56-64	neuregulin 1	Homo sapiens	47-52
24446128-7	2014	Compared to control, formalin-injected prostate exhibited a 2.5-fold to sixfold increased protein expression of IL-1alpha, IL-1beta, and IL-6.	Formaldehyde	21-29	interleukin 1 alpha	Rattus norvegicus	112-121
25911848-7	2014	We analyzed exon 15 of the BRAF gene in isolated DNA from 80 Formalin Fixed Paraffin-embedded (FFPE) CRC tumor tissues using PCR-RFLP method.	Formaldehyde	61-69	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	27-31
24446128-7	2014	Compared to control, formalin-injected prostate exhibited a 2.5-fold to sixfold increased protein expression of IL-1alpha, IL-1beta, and IL-6.	Formaldehyde	21-29	interleukin 1 beta	Rattus norvegicus	123-131
24446128-7	2014	Compared to control, formalin-injected prostate exhibited a 2.5-fold to sixfold increased protein expression of IL-1alpha, IL-1beta, and IL-6.	Formaldehyde	21-29	interleukin 6	Rattus norvegicus	137-141
24529991-5	2014	We show that DBs specifically detect the activated HER2/HER3 complex in formalin-fixed, paraffin-embedded cancer cells and exhibit superior detection specificity for phospho-HER3 compared to the corresponding monoclonal antibody.	Formaldehyde	72-80	erb-b2 receptor tyrosine kinase 2	Homo sapiens	51-55
29913682-14	2014	Moreover, hph-1 mice showed decreased nociception in the first phase of the formalin test.	Formaldehyde	76-84	hyperphenylalaninemia 1	Mus musculus	10-15
24529991-5	2014	We show that DBs specifically detect the activated HER2/HER3 complex in formalin-fixed, paraffin-embedded cancer cells and exhibit superior detection specificity for phospho-HER3 compared to the corresponding monoclonal antibody.	Formaldehyde	72-80	erb-b2 receptor tyrosine kinase 3	Homo sapiens	56-60
24493713-9	2014	Profiling six FISH biomarkers (GLI2, MYC, chromosome 11 [chr11], chr14, 17p, and 17q) on formalin-fixed paraffin-embedded tissues, we can reliably and reproducibly identify very low-risk and very high-risk patients within SHH, Group 3, and Group 4 medulloblastomas.	Formaldehyde	89-97	sonic hedgehog signaling molecule	Homo sapiens	222-225
24248894-6	2014	Emerging studies show that miR-21 could be measured stably and easily in tumor tissues, formalin-fixed paraffin-embedded tissues and blood circulation.	Formaldehyde	88-96	microRNA 21	Homo sapiens	27-33
24533895-1	2014	The salt Fe(OTf)3 has been shown to function as an effective catalyst in three different reactions, epoxide oxidative ring-opening to an alpha-hydroxy ketone, urea alpha-diketone condensation to form glycolurils, and glycoluril diether synthesis by formaldehyde condensation.	Formaldehyde	249-261	POU class 5 homeobox 1	Homo sapiens	12-17
24603753-7	2014	Scoring guidelines to aid in the evaluation of ERCC1 tumor expression were developed and evaluated in archival formalin-fixed paraffin embedded colorectal cancer specimens.	Formaldehyde	111-119	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	47-52
24598860-9	2014	Furthermore, COX-2 expression in the spinal dorsal horns of the pain model mice induced by formalin was significantly down-regulated by MEAP.	Formaldehyde	91-99	cytochrome c oxidase II, mitochondrial	Mus musculus	13-18
24624358-0	2014	Pyrosequencing as a fast and reliable method in detecting the MYD88 p.L265P mutation in decalcified formalin-fixed and paraffin-embedded tissues.	Formaldehyde	100-108	MYD88 innate immune signal transduction adaptor	Homo sapiens	62-67
23808402-4	2014	The BRAF assay was fully characterized by using plasmids and genomic DNA extracted from cell lines, metastatic colorectal cancer formalin-fixed, paraffin-embedded (FFPE) tissues, and thyroid nodule fine-needle aspirates.	Formaldehyde	129-137	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	4-8
24303983-0	2014	A role for PPARalpha in the medial prefrontal cortex in formalin-evoked nociceptive responding in rats.	Formaldehyde	56-64	peroxisome proliferator activated receptor alpha	Rattus norvegicus	11-20
24303983-4	2014	Here, we investigated the effects of pharmacological modulation of PPARalpha in the rat mPFC on formalin-evoked nociceptive behaviour and the impact of formalin-induced nociception on components of PPARalpha signalling in the mPFC.	Formaldehyde	152-160	peroxisome proliferator activated receptor alpha	Rattus norvegicus	198-207
24303983-6	2014	Quantitative real-time PCR and LC-MS/MS were used to study the effects of intraplantar injection of formalin on PPARalpha mRNA expression and levels of endogenous ligands, respectively, in the mPFC.	Formaldehyde	100-108	peroxisome proliferator activated receptor alpha	Rattus norvegicus	112-121
24303983-8	2014	Furthermore, formalin-evoked nociceptive behaviour was associated with significant reductions in mPFC levels of endogenous PPARalpha ligands (N-palmitoylethanolamide and N-oleoylethanolamide) and a 70% reduction in PPARalpha mRNA but not protein expression.	Formaldehyde	13-21	peroxisome proliferator activated receptor alpha	Rattus norvegicus	123-132
24303983-8	2014	Furthermore, formalin-evoked nociceptive behaviour was associated with significant reductions in mPFC levels of endogenous PPARalpha ligands (N-palmitoylethanolamide and N-oleoylethanolamide) and a 70% reduction in PPARalpha mRNA but not protein expression.	Formaldehyde	13-21	peroxisome proliferator activated receptor alpha	Rattus norvegicus	215-224
24303983-9	2014	CONCLUSIONS AND IMPLICATIONS: These data suggest that endogenous ligands may act at PPARalpha in the mPFC to play a facilitatory/permissive role in second phase formalin-evoked nociceptive behaviour in rats.	Formaldehyde	161-169	peroxisome proliferator activated receptor alpha	Rattus norvegicus	84-93
24169260-3	2014	PATIENTS AND METHODS: Mutations in TP53 (exons 4-9), KRAS (exon 1), and EGFR (exons 18-21) were identified by direct sequencing of DNA from formalin-fixed, paraffin-embedded resected tumors.	Formaldehyde	140-148	tumor protein p53	Homo sapiens	35-39
24172202-3	2014	OBJECTIVE: To explore the clinicopathological significance of the miR-146a level in HCC formalin-fixed paraffin-embedded (FFPE) tissue.	Formaldehyde	88-96	microRNA 146a	Homo sapiens	66-74
24531553-4	2014	Animals exposed to intraplantar formalin or bradykinin injection exhibited CASP6 activation in the dorsal horn.	Formaldehyde	32-40	caspase 6	Mus musculus	75-80
24531553-6	2014	Furthermore, formalin-induced second-phase pain was suppressed by spinal injection of CASP6 inhibitor or CASP6-neutralizing antibody, as well as perisciatic nerve injection of CASP6 siRNA.	Formaldehyde	13-21	caspase 6	Mus musculus	86-91
24531553-6	2014	Furthermore, formalin-induced second-phase pain was suppressed by spinal injection of CASP6 inhibitor or CASP6-neutralizing antibody, as well as perisciatic nerve injection of CASP6 siRNA.	Formaldehyde	13-21	caspase 6	Mus musculus	105-110
24531553-6	2014	Furthermore, formalin-induced second-phase pain was suppressed by spinal injection of CASP6 inhibitor or CASP6-neutralizing antibody, as well as perisciatic nerve injection of CASP6 siRNA.	Formaldehyde	13-21	caspase 6	Mus musculus	105-110
26064856-5	2014	METHODS: Immunohistochemical staining for VEGFR-1 was performed on 126 formalin-fixed paraffin-embedded CCRCC tissue samples.	Formaldehyde	71-79	fms related receptor tyrosine kinase 1	Homo sapiens	42-49
24162004-1	2014	We describe a case of human Becker muscular dystrophy (BMD)-like myopathy that was characterized by the declined stainability of dystrophin at sarcolemma in a pig and the immunostaining for dystrophin on the formalin-fixed, paraffin-embedded (FFPE) tissue.	Formaldehyde	208-216	dystrophin	Sus scrofa	190-200
24379281-2	2014	Spherules are the tissue form of Coccidioides, and we determined that the MR on bone marrow-derived dendritic cells (BMDC) was important for recognition of spherules (formalin-killed spherules [FKS]) and for secretion of interleukin 10 (IL-10) and proinflammatory cytokines in response to FKS by both elicited macrophages and BMDC.	Formaldehyde	167-175	interleukin 10	Mus musculus	237-242
25119009-7	2014	With the present study and based on our previous experience we would like to suggest the NUCKS protein as a novel proliferation marker for immunohistochemical evaluation of formalin-fixed and paraffin-embedded skin tumor specimens.	Formaldehyde	173-181	nuclear casein kinase and cyclin dependent kinase substrate 1	Homo sapiens	89-94
24563687-4	2014	To this end we optimised antibodies against the proline-hydroxylated forms of HIF-1alpha for use in formalin fixed paraffin embedded (FFPE) immunohistochemistry to assess effects in tumour cells in vivo.	Formaldehyde	100-108	hypoxia inducible factor 1 subunit alpha	Homo sapiens	78-88
24247001-6	2014	Furthermore, intrathecal administration of HK-1 (1-5) and SP (1-5) markedly attenuated the induction of flinching and enhancement of c-Fos expression in the spinal cord following the intradermal administration of formalin, a noxious stimulant, while pretreatment with HK-1 (1-5), but not SP (1-5), markedly attenuated the induction of scratching behavior by subcutaneous administration of pruritic agents, such as serotonin or histamine.	Formaldehyde	213-221	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	133-138
24587076-0	2014	Hydrogen sulfide inhibits formaldehyde-induced endoplasmic reticulum stress in PC12 cells by upregulation of SIRT-1.	Formaldehyde	26-38	sirtuin 1	Rattus norvegicus	109-115
24491146-2	2014	In this current report, two potent and selective 5HT2C full agonists, WAY-163909 (2) and vabicaserin (3), were radiolabeled with carbon-11 via Pictet-Spengler cyclization with [(11)C]formaldehyde and used in positron emission tomography (PET) imaging.	Formaldehyde	183-195	5-hydroxytryptamine receptor 2C	Homo sapiens	49-54
24696733-2	2014	This study was to evaluate the potential predictive value of miR-98 expression in formalin-fixed paraffin-embedded tissue of breast cancer patients.	Formaldehyde	82-90	microRNA 98	Homo sapiens	61-67
24696733-9	2014	These results suggest that over-expression of miR-98 in formalin-fixed paraffin-embedded tissues might serve as a valuable source for biomarker discovery in breast cancer patients.	Formaldehyde	56-64	microRNA 98	Homo sapiens	46-52
24467211-4	2014	This is the first report on the mechanism of the GLDC-catalyzed reaction and shows that GLDC is an unusual PLP-containing alpha-amino acid decarboxylase that removes carbon dioxide from the glycine substrate without releasing the expected amine (methylamine, a metabolic precursor of toxic formaldehyde) as a product.	Formaldehyde	290-302	glycine decarboxylase	Homo sapiens	88-92
24467211-4	2014	This is the first report on the mechanism of the GLDC-catalyzed reaction and shows that GLDC is an unusual PLP-containing alpha-amino acid decarboxylase that removes carbon dioxide from the glycine substrate without releasing the expected amine (methylamine, a metabolic precursor of toxic formaldehyde) as a product.	Formaldehyde	290-302	glycine decarboxylase	Homo sapiens	49-53
24167084-6	2014	RESULTS: PC9 and 11-18 cell lines in formalin-based fixatives showed strong staining of EGFR mutation-specific antibodies and lung cancer detection markers by ICC as compared with ethanol-based fixatives.	Formaldehyde	37-45	proprotein convertase subtilisin/kexin type 9	Homo sapiens	9-12
24502396-0	2014	Establishment of monoclonal anti-human CD26 antibodies suitable for immunostaining of formalin-fixed tissue.	Formaldehyde	86-94	dipeptidyl peptidase 4	Homo sapiens	39-43
24502396-3	2014	Since detection of tumor CD26 expression is required for determining potential eligibility for YS110 therapy, the development of anti-human CD26 mAb that can clearly and reliably detect the denatured CD26 molecule in the formalin-fixed paraffin-embedded tissues is critical.	Formaldehyde	221-229	dipeptidyl peptidase 4	Homo sapiens	140-144
24502396-3	2014	Since detection of tumor CD26 expression is required for determining potential eligibility for YS110 therapy, the development of anti-human CD26 mAb that can clearly and reliably detect the denatured CD26 molecule in the formalin-fixed paraffin-embedded tissues is critical.	Formaldehyde	221-229	dipeptidyl peptidase 4	Homo sapiens	140-144
24502396-7	2014	RESULTS: We have succeeded in developing novel anti-human CD26 mAbs suitable for immunohistochemical staining of CD26 in formalin-fixed tissue sections with reliable clarity and intensity.	Formaldehyde	121-129	dipeptidyl peptidase 4	Homo sapiens	58-62
24502396-7	2014	RESULTS: We have succeeded in developing novel anti-human CD26 mAbs suitable for immunohistochemical staining of CD26 in formalin-fixed tissue sections with reliable clarity and intensity.	Formaldehyde	121-129	dipeptidyl peptidase 4	Homo sapiens	113-117
24119304-10	2014	treatment with beta-CD/EO was significantly (p &lt; 0.05 or p &lt; 0.001) capable of reducing the nociceptive face-rubbing behaviour in both phases of the formalin test.	Formaldehyde	155-163	beta-carotene oxygenase 1	Mus musculus	15-22
24167084-6	2014	RESULTS: PC9 and 11-18 cell lines in formalin-based fixatives showed strong staining of EGFR mutation-specific antibodies and lung cancer detection markers by ICC as compared with ethanol-based fixatives.	Formaldehyde	37-45	epidermal growth factor receptor	Homo sapiens	88-92
24447452-0	2014	Detection of constitutive and inducible HSP70 proteins in formalin fixed human brain tissue.	Formaldehyde	58-66	heat shock protein family A (Hsp70) member 4	Homo sapiens	40-45
23861142-5	2014	METHODS: For this, we tested mutant Zeb2 animals in different models of inflammatory pain like abdominal constriction, formalin and carrageenan test.	Formaldehyde	119-127	zinc finger E-box binding homeobox 2	Mus musculus	36-40
23873727-7	2014	RESULTS: Intra-plantar injection of formalin resulted in an increase in Zif268 and Sgk1 mRNA expression in the ipsilateral DHSC of non-fear-conditioned rats, effects not observed in rats expressing FCA.	Formaldehyde	36-44	early growth response 1	Rattus norvegicus	72-78
23873727-7	2014	RESULTS: Intra-plantar injection of formalin resulted in an increase in Zif268 and Sgk1 mRNA expression in the ipsilateral DHSC of non-fear-conditioned rats, effects not observed in rats expressing FCA.	Formaldehyde	36-44	serum/glucocorticoid regulated kinase 1	Rattus norvegicus	83-87
24333852-5	2014	We first converted this antibody into bivalent IgG, and verified its ability to recognize PAPP-A in sections of formalin-fixed and paraffin-embedded tissue.	Formaldehyde	112-120	pappalysin 1	Homo sapiens	90-96
23299277-3	2014	METHODS: KRAS status was evaluated in 105 pairs of formalin-fixed primary colorectal cancer and corresponding liver metastases specimens by direct sequencing.	Formaldehyde	51-59	KRAS proto-oncogene, GTPase	Homo sapiens	9-13
24098023-5	2014	Formalin fixed paraffin embedded tissue sections from malignant melanoma patients were distributed to participants for BRAF molecular testing.	Formaldehyde	0-8	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	119-123
24285342-5	2014	Furthermore, using in situ hybridization, we measured HOTAIR expression in 129 formalin-fixed paraffin-embedded (FFPE) tissue sections, which included 96 tissues that matched the frozen cases, 21 other EC tissues and 12 atypical hyperplasia tissues.	Formaldehyde	79-87	HOX transcript antisense RNA	Homo sapiens	54-60
24555932-8	2014	MAb 5A5 detects HPCAL1 in formalin-fixed, paraffin-embedded pancreatic cancer cell lines, making it a potentially useful reagent for pathologists.	Formaldehyde	26-34	hippocalcin-like 1	Mus musculus	16-22
24627693-6	2014	Prolonged formalin fixation resulted in fewer GAPDH and beta-actin PCR products, and amplification of hGH was not successful.	Formaldehyde	10-18	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	46-51
24627693-6	2014	Prolonged formalin fixation resulted in fewer GAPDH and beta-actin PCR products, and amplification of hGH was not successful.	Formaldehyde	10-18	POTE ankyrin domain family member F	Homo sapiens	56-66
24450308-9	2014	In addition, flinching or licking behavior after bradykinin or formalin injection was also significantly reduced in Adv/Ano1fl/fl mice.	Formaldehyde	63-71	anoctamin 1, calcium activated chloride channel	Mus musculus	120-124
24355293-9	2014	In the formalin-induced nociception, 1.5-DHP (10mg/kg, p.o.)	Formaldehyde	7-15	dihydropyrimidinase	Homo sapiens	41-44
24516345-13	2014	There was a significant increase in plasma TNF-alpha (p = 0.048) and IL-6 (p = 0.014) levels after formalin-induced pain.	Formaldehyde	99-107	tumor necrosis factor	Mus musculus	43-52
24498195-7	2014	Levels in p-ERK and p-Cdk5 were also increased in the 2(nd) phase of hyperalgesia induced by formalin injection, which can produce acute and tonic inflammatory pain.	Formaldehyde	93-101	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	10-15
24498195-7	2014	Levels in p-ERK and p-Cdk5 were also increased in the 2(nd) phase of hyperalgesia induced by formalin injection, which can produce acute and tonic inflammatory pain.	Formaldehyde	93-101	cyclin dependent kinase 5	Homo sapiens	22-26
24231552-3	2014	The number of c-Fos-activated neurons in the dorsal horn was increased after hind paw injection of capsaicin, formalin or complete Freund"s adjuvant (CFA, 1.5 hrs - 4 days).	Formaldehyde	110-118	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	14-19
24516345-13	2014	There was a significant increase in plasma TNF-alpha (p = 0.048) and IL-6 (p = 0.014) levels after formalin-induced pain.	Formaldehyde	99-107	interleukin 6	Mus musculus	69-73
23791475-6	2014	These findings show that WT1 is a reliable marker of human sympathetic neuroblasts, which can be used routinely in formalin-fixed, paraffin-embedded tissues.	Formaldehyde	115-123	WT1 transcription factor	Homo sapiens	25-28
24287180-4	2014	Immunohistochemistry staining was adopted to determine the expression of SIRT3 in 65 formalin-fixed, paraffin-embedded samples from GC patients.	Formaldehyde	85-93	sirtuin 3	Homo sapiens	73-78
24287180-8	2014	Furthermore, immunohistochemistry analysis of 65 formalin-fixed, paraffin-embedded samples from GC patients showed that 67.7% (44/65) had decreased SIRT3 staining in the cancer tissues.	Formaldehyde	49-57	sirtuin 3	Homo sapiens	148-153
24281232-3	2014	STUDY DESIGN: Arginase-1 and HepPar-1 IHC was performed on formalin-fixed, paraffin-embedded fine needle aspiration (FNA) cell blocks (CB) of PAD (n = 46), tissue microarray (TMA) of PAD (n = 33), FNA CB of HCC (n = 44) and TMA of HCC (n = 85).	Formaldehyde	59-67	arginase 1	Homo sapiens	14-41
23702645-4	2014	METHODS: HER2 protein expression was investigated using a FDA-approved antibody in 87 formalin-fixed and paraffin-embedded cases of PDAC with complete follow-up.	Formaldehyde	86-94	erb-b2 receptor tyrosine kinase 2	Homo sapiens	9-13
24145648-4	2014	Here, we characterize the new monoclonal anti-SOX11 antibodies, suitable for Western blot assay and immunohistochemistry (IHC) on formalin-fixed paraffin-embedded tissue; we tested them on a large series of primary lymphoid tumors and compared these results with those of other routinely used antibodies.	Formaldehyde	130-138	SRY-box transcription factor 11	Homo sapiens	46-51
24998573-4	2014	METHODS: miR-152 expression was detected using real-time quantitative RT-PCR in 89 pairs of HCC formalin-fixed paraffin-embedded and their adjacent tissues.	Formaldehyde	96-104	microRNA 152	Homo sapiens	9-16
24377577-0	2014	High resolution melting analysis for epidermal growth factor receptor mutations in formalin-fixed paraffin-embedded tissue and plasma free DNA from non-small cell lung cancer patients.	Formaldehyde	83-91	epidermal growth factor receptor	Homo sapiens	37-69
25040984-12	2014	MMP and Bcl-2 expression were decreased with increasing formaldehyde concentration, while expression of Bax and Cyt C was increased.	Formaldehyde	56-68	B cell leukemia/lymphoma 2	Mus musculus	8-13
25169519-4	2014	MATERIALS AND METHODS: C13orf18 and C1orf166 (MUL1 or Mulan) DNA methylation as potential biomarkers and risk factors was investigated in 112 liquid based cytology and Formalin-Fixed Paraffin- Embedded tissue specimens in Iranian females with cervical intraepithelial neoplasia and dysplasia.	Formaldehyde	168-176	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	36-44
25169519-4	2014	MATERIALS AND METHODS: C13orf18 and C1orf166 (MUL1 or Mulan) DNA methylation as potential biomarkers and risk factors was investigated in 112 liquid based cytology and Formalin-Fixed Paraffin- Embedded tissue specimens in Iranian females with cervical intraepithelial neoplasia and dysplasia.	Formaldehyde	168-176	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	46-50
25169552-4	2014	MATERIALS AND METHODS: The expression levels of miR-15a were analysed in BC formalin fixed paraffin embedded (FFPE) tissues by microarray and quantitative real-time PCR.	Formaldehyde	76-84	microRNA 15a	Homo sapiens	48-55
25081715-4	2014	MATERIALS AND METHODS: Immunohistochemistry was applied to evaluate TLR9 expression in 97 formalin-fixed paraffin-embedded cervical samples from Uyghur women; 32 diagnosed with cervical squamous cell carcinomas (CSCC) , 14 with low-grade cervical intraepithelial neoplasias (CINI), 10 medium-grade (CINII), 24 high-grade (CINIII), and 17 chronic cervicitis.	Formaldehyde	90-98	toll like receptor 9	Homo sapiens	68-72
25124588-4	2014	The present study was undertaken to determine the level of TLR9 expression in cervical neoplasias from Tunisian women with 53 formalin-fixed and paraffin-embedded specimens, including 22 samples of invasive cervical carcinoma (ICC), 18 of cervical intraepithelial neoplasia (CIN), 7 of condyloma and 6 normal cervical tissues as control cases.	Formaldehyde	126-134	toll like receptor 9	Homo sapiens	59-63
25422191-8	2014	The detection of DcR3 protein in the formalin- fixed and paraffin-embedded samples could assist to predict in prognosis of BUC patients.	Formaldehyde	37-45	TNF receptor superfamily member 6b	Homo sapiens	17-21
24626199-1	2014	FANCD2 is required for the repair of DNA damage by the FA (Fanconi anemia) pathway, and, consequently, FANCD2-deficient cells are sensitive to compounds such as cisplatin and formaldehyde that induce DNA:DNA and DNA:protein crosslinks, respectively.	Formaldehyde	175-187	FA complementation group D2	Homo sapiens	0-6
24815433-3	2014	The aim of this study was to detect the expression of lncRNA MALAT1 in PDAC formalin-fixed, paraffin embedded (FFPE) tissues and to investigate the clinical significance of the MALAT1 level.	Formaldehyde	76-84	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	61-67
24152609-0	2014	Sigma-1 receptor antagonist, BD1047 reduces nociceptive responses and phosphorylation of p38 MAPK in mice orofacial formalin model.	Formaldehyde	116-124	sigma non-opioid intracellular receptor 1	Mus musculus	0-16
24152609-0	2014	Sigma-1 receptor antagonist, BD1047 reduces nociceptive responses and phosphorylation of p38 MAPK in mice orofacial formalin model.	Formaldehyde	116-124	mitogen-activated protein kinase 14	Mus musculus	89-97
24152609-3	2014	Here we show whether a selective Sig-1R antagonist, BD1047 reduces nociceptive responses in the mouse orofacial formalin model and the number of Fos-immunoreactive (ir) cells in the trigeminal nucleus caudalis (TNC).	Formaldehyde	112-120	sigma non-opioid intracellular receptor 1	Mus musculus	33-39
24895573-1	2014	Previously, we found that the expression of microRNA-146a (miR-146a) was downregulated in hepatocellular carcinoma (HCC) formalin-fixed paraffin-embedded (FFPE) tissues compared to the adjacent noncancerous hepatic tissues.	Formaldehyde	121-129	microRNA 146a	Homo sapiens	44-57
24895573-1	2014	Previously, we found that the expression of microRNA-146a (miR-146a) was downregulated in hepatocellular carcinoma (HCC) formalin-fixed paraffin-embedded (FFPE) tissues compared to the adjacent noncancerous hepatic tissues.	Formaldehyde	121-129	microRNA 146a	Homo sapiens	59-67
24528049-3	2014	MATERIALS AND METHODS: In this prospective study, EGFR mutations in exons 18, 19, 20 and 21 in formalin-fixed paraffin-embedded biopsy specimens of consecutive NSCLC patients were asessed by real-time polymerase chain reaction.	Formaldehyde	95-103	epidermal growth factor receptor	Homo sapiens	50-54
23073516-1	2014	BACKGROUND: Investigation of p53 immunoreactivity in formalin-fixed paraffin-embedded tissues of normal renal tissue and renal cell carcinoma with respect to histopathologic subtype and nuclear grade of RCC.	Formaldehyde	53-61	tumor protein p53	Homo sapiens	29-32
24877104-6	2014	DAPK protein expression was performed using immunohistochemical assays in formalin-fixed, paraffin-embedded sections.	Formaldehyde	74-82	death associated protein kinase 1	Homo sapiens	0-4
24626199-1	2014	FANCD2 is required for the repair of DNA damage by the FA (Fanconi anemia) pathway, and, consequently, FANCD2-deficient cells are sensitive to compounds such as cisplatin and formaldehyde that induce DNA:DNA and DNA:protein crosslinks, respectively.	Formaldehyde	175-187	FA complementation group D2	Homo sapiens	103-109
24626199-3	2014	A knockdown of DNA2 renders normal cells as sensitive to cisplatin (in the absence of EXO1) and to formaldehyde (even in the presence of EXO1) as FANCD2(-/-) cells.	Formaldehyde	99-111	DNA replication helicase/nuclease 2	Homo sapiens	15-19
24626199-4	2014	Surprisingly, however, the depletion of DNA2 in FANCD2-deficient cells rescues the sensitivity of FANCD2(-/-) cells to cisplatin and formaldehyde.	Formaldehyde	133-145	DNA replication helicase/nuclease 2	Homo sapiens	40-44
24626199-4	2014	Surprisingly, however, the depletion of DNA2 in FANCD2-deficient cells rescues the sensitivity of FANCD2(-/-) cells to cisplatin and formaldehyde.	Formaldehyde	133-145	FA complementation group D2	Homo sapiens	48-54
24626199-4	2014	Surprisingly, however, the depletion of DNA2 in FANCD2-deficient cells rescues the sensitivity of FANCD2(-/-) cells to cisplatin and formaldehyde.	Formaldehyde	133-145	FA complementation group D2	Homo sapiens	98-104
23848345-7	2014	For type IV allergens, significantly more FLG loss-of-function carriers were found to be sensitized to lanolin and p-tert-butylphenol-formaldehyde resin.	Formaldehyde	134-146	filaggrin	Homo sapiens	42-45
24890176-0	2014	A simple and efficient method of DNA extraction from formalin-fixed and paraffin-embedded tissues for screening EGFR gene mutation by gene sequencing.	Formaldehyde	53-61	epidermal growth factor receptor	Homo sapiens	112-116
24413452-4	2014	MATERIALS AND METHODS: Immunohistochemical staining for EZH2 was performed on formalin-fixed paraffin-embedded biopsies and a tissue microarray containing normal skin, AK, SCC in situ, and SCC of different grades.	Formaldehyde	78-86	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	56-60
24852851-1	2014	We describe a case of formaldehyde-induced urticaria with a positive test result for serum IgE antibody against this substance.	Formaldehyde	22-34	immunoglobulin heavy constant epsilon	Homo sapiens	91-94
23754308-5	2014	Lastly, formalin-evoked NK1r internalization was assessed across the female oestrous cycle.	Formaldehyde	8-16	tachykinin receptor 1	Rattus norvegicus	24-28
23754308-6	2014	RESULTS: Intraplantar formalin evoked significant NK1r internalization, during phase 1 and 2, in both males and females.	Formaldehyde	22-30	tachykinin receptor 1	Rattus norvegicus	50-54
23754308-11	2014	Formalin-evoked NK1r internalization did not differ across the oestrous cycle.	Formaldehyde	0-8	tachykinin receptor 1	Rattus norvegicus	16-20
25007176-4	2014	Mutation status of GNAS1 exon 8 was analyzed in one hundred thirty-five formalin-fixed, paraffin-embedded (FFPE) gastrointestinal tumor samples including 45 tubular-villous adenomas, 11 tubular adenomas, 6 villousadenomas, 10 hyperplastic gastric polyps, 31 GEP-NETs and 32 colorectal adenocarcinomas by using polymerase chain reaction (PCR) and direct sequencing.	Formaldehyde	72-80	GNAS complex locus	Homo sapiens	19-24
24262879-2	2014	METHODS: We assessed PIK3CA mutational status in exon 9 and exon 20 hot spots by Sanger sequencing of DNA derived from formalin fixed paraffin embedded tissue of 57 grade 3 endometrioid, 26 serous, 11 clear cell and 5 dedifferentiated carcinomas.	Formaldehyde	119-127	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	21-27
25437654-7	2014	Reverse transcription polymerase chain reaction from a formalin-fixed, paraffin-embedded biopsy specimen revealed a FUS-CREB3L2 gene fusion (exon6/int/exon5), leading to the diagnosis of LGFMS.	Formaldehyde	55-63	FUS RNA binding protein	Homo sapiens	116-119
24300539-1	2014	The aims of this study were to assess the overexpression of p16 in formalin-fixed paraffin-embedded cervical carcinoma tissue blocks and to determine its concordance with the human papillomavirus (HPV) status using the SPF10-LiPA25 polymerase chain reaction System and its correlation with the histologic type of invasive cervical cancer (ICC) and individual HPV genotypes.	Formaldehyde	67-75	cyclin dependent kinase inhibitor 2A	Homo sapiens	60-63
24300539-7	2014	When performed on formalin-fixed paraffin-embedded cervical tissue specimens, the higher positivity rate of p16 immunohistochemistry as compared with HPV DNA testing may allow identifying HPV-related ICC cases in which HPV testing was negative.	Formaldehyde	18-26	cyclin dependent kinase inhibitor 2A	Homo sapiens	108-111
25437654-7	2014	Reverse transcription polymerase chain reaction from a formalin-fixed, paraffin-embedded biopsy specimen revealed a FUS-CREB3L2 gene fusion (exon6/int/exon5), leading to the diagnosis of LGFMS.	Formaldehyde	55-63	cAMP responsive element binding protein 3 like 2	Homo sapiens	120-127
24908312-2	2014	The described protocol has been optimized for IL-1 detection in formalin-fixed paraffin-embedded oral tissue sections by light microscopy.	Formaldehyde	64-72	interleukin 1 alpha	Homo sapiens	46-50
24410688-4	2014	Results of batch ZVI reduction experiments showed that DNAN was completely reduced to 2,4-diaminoanisole and RDX was completely reduced to formaldehyde.	Formaldehyde	139-151	radixin	Homo sapiens	109-112
24346090-2	2014	METHODS: We developed a panel of single and multiplex RT-PCR assays suitable for rapid and accurate detection of the eight most common EML4-ALK+ variants and ALK gene expression in archival formalin-fixed, paraffin-embedded NSCLC specimens.	Formaldehyde	190-198	ALK receptor tyrosine kinase	Homo sapiens	158-161
24346090-11	2014	CONCLUSIONS: This panel of variant-specific, quantitative RT-PCR assays detects common EML4-ALK+ variants as well as ALK gene expression level in archival formalin-fixed paraffin-embedded NSCLC specimens.	Formaldehyde	155-163	ALK receptor tyrosine kinase	Homo sapiens	117-120
24401792-9	2014	The number of c-Fos-IR cells in the VcI/II at every level (0-3.6 mm caudal to the obex) after formalin injection was significantly decreased (p &lt; 0.01) with preadministration of morphine (3 mg/kg) or buprenorphine (100 microg/kg) in the control rats.	Formaldehyde	94-102	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	14-19
24258984-3	2014	With the discovery of lymphatic endothelial cell markers, such as podoplanin and LYVE-1, lymphatic vessels can be reliably detected in formalin-fixed paraffin-embedded (FFPE) tissues.	Formaldehyde	135-143	lymphatic vessel endothelial hyaluronan receptor 1	Homo sapiens	81-87
24738289-9	2014	Formalin treatment changes immunochemical properties of APV LPS that lead to the shift of precipitation bands with pertussis agglutinating sera from the start zone into cathode.	Formaldehyde	0-8	toll-like receptor 4	Mus musculus	60-63
24738289-14	2014	CONCLUSION: Formalin-neutralized APV preparation is a complex of protein antigens in association with LPS.	Formaldehyde	12-20	toll-like receptor 4	Mus musculus	102-105
24738289-15	2014	Formalin treatment results in modification of LPS molecule that retains antigenic properties but is significantly less toxic.	Formaldehyde	0-8	toll-like receptor 4	Mus musculus	46-49
24358187-6	2013	Single microRNA RT-qPCR was conducted on formalin-fixed paraffin-embedded tumor biopsies of 20 additional cases, confirming higher expression of miR-9-5p, miR-31-5p, miR-129-2-3p and miR-214-3p in PCFCL as compared to PCLBCL-LT. MicroRNAs previously described to be higher expressed in ABC-type as compared to GCB-type nodal DLBCL were not differentially expressed between PCFCL and PCLBCL-LT.	Formaldehyde	41-49	microRNA 95	Homo sapiens	145-153
24358179-1	2013	Fixation in 10% neutral buffered formalin prior to transfer to 70% ethanol for one week has been shown to adequately preserve immunorecognition of PCNA, cytokeratins AE1/AE3 and EGFr.	Formaldehyde	33-41	proliferating cell nuclear antigen	Homo sapiens	147-151
24358179-1	2013	Fixation in 10% neutral buffered formalin prior to transfer to 70% ethanol for one week has been shown to adequately preserve immunorecognition of PCNA, cytokeratins AE1/AE3 and EGFr.	Formaldehyde	33-41	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	166-169
24358179-1	2013	Fixation in 10% neutral buffered formalin prior to transfer to 70% ethanol for one week has been shown to adequately preserve immunorecognition of PCNA, cytokeratins AE1/AE3 and EGFr.	Formaldehyde	33-41	solute carrier family 4 member 3	Homo sapiens	170-173
24358179-1	2013	Fixation in 10% neutral buffered formalin prior to transfer to 70% ethanol for one week has been shown to adequately preserve immunorecognition of PCNA, cytokeratins AE1/AE3 and EGFr.	Formaldehyde	33-41	epidermal growth factor receptor	Homo sapiens	178-182
24225951-2	2013	Dipeptidyl aminopeptidase-like protein 6 (DPP6) was first identified as a PrP(C) interactor using in vivo formaldehyde cross-linking of wild type (WT) mouse brain.	Formaldehyde	106-118	dipeptidylpeptidase 6	Mus musculus	0-40
24225951-2	2013	Dipeptidyl aminopeptidase-like protein 6 (DPP6) was first identified as a PrP(C) interactor using in vivo formaldehyde cross-linking of wild type (WT) mouse brain.	Formaldehyde	106-118	dipeptidylpeptidase 6	Mus musculus	42-46
23838921-6	2013	Immunohistochemical staining was used to determine the expression of GOLM1 in archived formalin-fixed, paraffin-embedded tissue specimens.	Formaldehyde	87-95	golgi membrane protein 1	Homo sapiens	69-74
24336498-7	2013	Concordance of 100% was observed between unfixed and formalin-fixed for reported COSMIC variants including BRAF V600E.	Formaldehyde	53-61	Braf transforming gene	Mus musculus	107-111
24097869-8	2013	Bisulfite next-generation sequencing mapping of the NAPRT1 promoter identified tumor-specific sites of NAPRT1 DNA methylation and enabled the development of a quantitative methylation-specific PCR (QMSP) assay suitable for use on archival formalin-fixed paraffin-embedded tumor tissue.	Formaldehyde	239-247	nicotinate phosphoribosyltransferase	Homo sapiens	52-58
24097869-11	2013	NAPRT1-specific immunohistochemical or DNA methylation assays can be used on archival formalin paraffin-embedded cancer tissue to identify patients likely to benefit from coadministration of a Nampt inhibitor and nicotinic acid.	Formaldehyde	86-94	nicotinate phosphoribosyltransferase	Homo sapiens	0-6
24286402-5	2013	METHODS: We have therefore retrospectively examined expression of miR-30b miR-30c in 41 formalin fixed paraffin embedded tissue samples from NSCLC patients when TKIs were used as first line therapy.	Formaldehyde	88-96	microRNA 30b	Homo sapiens	66-73
23731771-5	2013	PRUNE2 expression was detected using immunohistochemistry in 30 formalin-fixed, paraffin-embedded leiomyosarcoma tissues from MD Anderson Cancer Center, and high expression was detected in 36.7% (11/30) of the samples.	Formaldehyde	64-72	prune homolog 2 with BCH domain	Homo sapiens	0-6
24286402-5	2013	METHODS: We have therefore retrospectively examined expression of miR-30b miR-30c in 41 formalin fixed paraffin embedded tissue samples from NSCLC patients when TKIs were used as first line therapy.	Formaldehyde	88-96	microRNA 30c-1	Homo sapiens	74-81
24473511-6	2013	RESULTS: Our results showed that previous exposure to formaldehyde in allergic rats decreased lung cell recruitment, tracheal reactivity, myeloperoxidase activity, vascular permeability and mast cell degranulation while increasing IL-10 levels.	Formaldehyde	54-66	myeloperoxidase	Rattus norvegicus	138-153
23892415-4	2013	We had evaluated the frequency of EGFR mutations with three highly sensitive PCR techniques in formalin-fixed, paraffin-embedded samples of 143 NSCLC patients with central nervous system (CNS) metastases.	Formaldehyde	95-103	epidermal growth factor receptor	Homo sapiens	34-38
24473511-6	2013	RESULTS: Our results showed that previous exposure to formaldehyde in allergic rats decreased lung cell recruitment, tracheal reactivity, myeloperoxidase activity, vascular permeability and mast cell degranulation while increasing IL-10 levels.	Formaldehyde	54-66	interleukin 10	Rattus norvegicus	231-236
24473511-9	2013	CONCLUSION: In conclusion, our study revealed that formaldehyde and ovariectomy downregulated allergic lung inflammation by IL-10 release and mast cell degranulation.	Formaldehyde	51-63	interleukin 10	Rattus norvegicus	124-129
24140967-0	2013	The ER stress-mediated decrease in DDAH1 expression is involved in formaldehyde-induced apoptosis in lung epithelial cells.	Formaldehyde	67-79	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	35-40
24193004-6	2013	We here propose a method for hERG1 gene quantification in colorectal cancer samples in both cryopreserved and formalin-fixed and paraffin-embedded samples.	Formaldehyde	110-118	potassium voltage-gated channel subfamily H member 2	Homo sapiens	29-34
23059809-7	2013	Formaldehyde significantly increased malondialdehyde (MDA) levels, and decreased superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activity.	Formaldehyde	0-12	superoxide dismutase 1	Homo sapiens	81-101
24385948-0	2013	Acute Phase Protein Lipocalin-2 Is Associated with Formalin-induced Nociception and Pathological Pain.	Formaldehyde	51-59	lipocalin 2	Mus musculus	20-31
24385948-5	2013	Formalin-induced nociceptive behaviors (licking/biting) and spinal microglial activation were significantly reduced in the second or late phase of the formalin test in Lcn2 knockout mice.	Formaldehyde	0-8	lipocalin 2	Mus musculus	168-172
24385948-5	2013	Formalin-induced nociceptive behaviors (licking/biting) and spinal microglial activation were significantly reduced in the second or late phase of the formalin test in Lcn2 knockout mice.	Formaldehyde	151-159	lipocalin 2	Mus musculus	168-172
25332513-0	2013	Immunohistochemical detection of arginase-I expression in formalin-fixed lung and other tissues.	Formaldehyde	58-66	arginase, liver	Mus musculus	33-43
25332513-3	2013	To define expression of murine arginase-I in formalin-fixed tissues, including lung, an immunohistochemical protocol was validated in murine liver; a tissue that has distinct zonal arginase-I expression making it a useful control.	Formaldehyde	45-53	arginase, liver	Mus musculus	31-41
24551639-3	2013	MATERIAL AND METHODS: We performed IHC detection of p16(INK4a) in sections of paraffin embedded formalin fixed tissues of leukoplakia with or without dysplasia (n= 21) and SCC lesions (n= 69) and correlated with various patterns of p16(INK4a) positivity with respect to histological diagnosis.	Formaldehyde	96-104	cyclin dependent kinase inhibitor 2A	Homo sapiens	52-55
24551639-3	2013	MATERIAL AND METHODS: We performed IHC detection of p16(INK4a) in sections of paraffin embedded formalin fixed tissues of leukoplakia with or without dysplasia (n= 21) and SCC lesions (n= 69) and correlated with various patterns of p16(INK4a) positivity with respect to histological diagnosis.	Formaldehyde	96-104	cyclin dependent kinase inhibitor 2A	Homo sapiens	56-61
23059809-7	2013	Formaldehyde significantly increased malondialdehyde (MDA) levels, and decreased superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activity.	Formaldehyde	0-12	superoxide dismutase 1	Homo sapiens	103-106
23707280-7	2013	However, many nNOS-positive inhibitory interneurons up-regulated Fos after noxious thermal stimulation or injection of formalin, but not after capsaicin injection.	Formaldehyde	119-127	nitric oxide synthase 1	Rattus norvegicus	14-18
23810829-6	2013	Intraplantar formalin caused robust neurokinin 1 receptor (NK1r) internalization (indicating SP release) and c-Fos expression in the ipsilateral dorsal horn, which were blocked by IT SNX-482.	Formaldehyde	13-21	tachykinin receptor 1	Rattus norvegicus	36-57
23810829-6	2013	Intraplantar formalin caused robust neurokinin 1 receptor (NK1r) internalization (indicating SP release) and c-Fos expression in the ipsilateral dorsal horn, which were blocked by IT SNX-482.	Formaldehyde	13-21	tachykinin receptor 1	Rattus norvegicus	59-63
23810829-6	2013	Intraplantar formalin caused robust neurokinin 1 receptor (NK1r) internalization (indicating SP release) and c-Fos expression in the ipsilateral dorsal horn, which were blocked by IT SNX-482.	Formaldehyde	13-21	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	109-114
24109593-9	2013	Lastly, formaldehyde-associated isolation of regulatory elements of human liver samples confirms open chromatin at IGF1 Promoter 1, but unexpectedly, homologous Stat5-binding motifs are not accessible.	Formaldehyde	8-20	insulin-like growth factor 1	Mus musculus	115-119
24259349-2	2013	HOXA11 hypermethylation was characterized in six lung cancer cell lines, and its clinical significance was analyzed using formalin-fixed paraffin-embedded tissues from 317 NSCLC patients, and Ki-67 expression was analyzed using immunohistochemistry.	Formaldehyde	122-130	homeobox A11	Homo sapiens	0-6
23873108-2	2013	Regulation of B cell-specific Moloney murine leukaemia virus integration site 1 (BMI1) expression with increase in histological grades of breast carcinoma in correlation with hormone receptor status was studied in 60 Indian breast cancer patient"s formalin-fixed paraffin-embedded tissue blocks.	Formaldehyde	248-256	Bmi1 polycomb ring finger oncogene	Mus musculus	81-85
24201047-3	2013	In this study, we tried to examine the effects of dopamine receptors located in the dorsal hippocampus (CA1) region upon the modulation of orofacial pain induced by the formalin test.	Formaldehyde	169-177	carbonic anhydrase 1	Rattus norvegicus	104-107
24278211-10	2013	CONCLUSIONS: The data suggest that measurement of both HER2 and phospho- Tyr(1248)HER2, in formalin-fixed tissue by immunological methods is significantly affected by pre-analytic variables.	Formaldehyde	91-99	erb-b2 receptor tyrosine kinase 2	Homo sapiens	55-59
24100522-0	2013	Reliable PCR quantitation of estrogen, progesterone and ERBB2 receptor mRNA from formalin-fixed, paraffin-embedded tissue is independent of prior macro-dissection.	Formaldehyde	81-89	erb-b2 receptor tyrosine kinase 2	Homo sapiens	56-61
24278211-10	2013	CONCLUSIONS: The data suggest that measurement of both HER2 and phospho- Tyr(1248)HER2, in formalin-fixed tissue by immunological methods is significantly affected by pre-analytic variables.	Formaldehyde	91-99	erb-b2 receptor tyrosine kinase 2	Homo sapiens	82-86
24244296-8	2013	AGAP could also decrease the expression of spinal Fos induced by formalin.	Formaldehyde	65-73	FBJ osteosarcoma oncogene	Mus musculus	50-53
23784051-3	2013	METHODS: We examined Lgr5 expression in 384 formalin-fixed paraffin-embedded CRC specimens from 296 CRC patients, including 64 patients treated with 5-fluorouracil (5-FU)-based chemotherapy.	Formaldehyde	44-52	leucine rich repeat containing G protein-coupled receptor 5	Homo sapiens	21-25
23978562-9	2013	Furthermore, intrathecal SNC80 (200 mug) blocked formalin-induced substance P release otherwise evoked in the ispilateral superficial dorsal horn as measured by NK1 receptor internalization.	Formaldehyde	49-57	tachykinin receptor 1	Rattus norvegicus	161-173
23994645-4	2013	This assay is successfully applied to the simultaneous detection of ERG3p, ERG5p, PTEN, and CEN10 genes in formalin-fixed, paraffin-embedded prostate tissues on BenchMark ULTRA instruments.	Formaldehyde	107-115	ETS transcription factor ERG	Homo sapiens	68-73
23994645-4	2013	This assay is successfully applied to the simultaneous detection of ERG3p, ERG5p, PTEN, and CEN10 genes in formalin-fixed, paraffin-embedded prostate tissues on BenchMark ULTRA instruments.	Formaldehyde	107-115	phosphatase and tensin homolog	Homo sapiens	82-86
23900131-0	2013	Simvastatin attenuates formalin-induced nociceptive behaviors by inhibiting microglial RhoA and p38 MAPK activation.	Formaldehyde	23-31	ras homolog family member A	Rattus norvegicus	87-91
23900131-0	2013	Simvastatin attenuates formalin-induced nociceptive behaviors by inhibiting microglial RhoA and p38 MAPK activation.	Formaldehyde	23-31	mitogen activated protein kinase 14	Rattus norvegicus	96-99
23702732-4	2013	Utilizing the data set from our previously performed DNA microarray studies on formalin-fixed and paraffin-embedded tissue, we found that the genes C15orf48 and KRT9 had a distinct and robust gene expression pattern in distinguishing squamous cell carcinoma from pseudoepitheliomatous hyperplasia.	Formaldehyde	79-87	chromosome 15 open reading frame 48	Homo sapiens	148-156
23900131-6	2013	In addition, peripheral formalin injection induced a significant increase in microglial RhoA activation (detected by membrane RhoA translocation ratio using Western blot) in the spinal cord.	Formaldehyde	24-32	ras homolog family member A	Rattus norvegicus	88-92
23900131-6	2013	In addition, peripheral formalin injection induced a significant increase in microglial RhoA activation (detected by membrane RhoA translocation ratio using Western blot) in the spinal cord.	Formaldehyde	24-32	ras homolog family member A	Rattus norvegicus	126-130
23900131-8	2013	These findings suggest that simvastatin attenuates formalin-induced nociceptive behaviors, at least in part, by inhibiting microglial RhoA and p38 mitogen-activated protein kinase activation.	Formaldehyde	51-59	ras homolog family member A	Rattus norvegicus	134-138
23900131-8	2013	These findings suggest that simvastatin attenuates formalin-induced nociceptive behaviors, at least in part, by inhibiting microglial RhoA and p38 mitogen-activated protein kinase activation.	Formaldehyde	51-59	mitogen activated protein kinase 14	Rattus norvegicus	143-146
23900131-9	2013	PERSPECTIVE: Our novel findings indicated that simvastatin attenuated formalin-induced nociceptive responses by inhibiting microglial RhoA and p38 mitogen-activated protein kinase activation.	Formaldehyde	70-78	ras homolog family member A	Rattus norvegicus	134-138
23900131-9	2013	PERSPECTIVE: Our novel findings indicated that simvastatin attenuated formalin-induced nociceptive responses by inhibiting microglial RhoA and p38 mitogen-activated protein kinase activation.	Formaldehyde	70-78	mitogen activated protein kinase 14	Rattus norvegicus	143-146
23702732-4	2013	Utilizing the data set from our previously performed DNA microarray studies on formalin-fixed and paraffin-embedded tissue, we found that the genes C15orf48 and KRT9 had a distinct and robust gene expression pattern in distinguishing squamous cell carcinoma from pseudoepitheliomatous hyperplasia.	Formaldehyde	79-87	keratin 9	Homo sapiens	161-165
24120766-1	2013	It has been described that endogenous ATP via activation of P2X3 and P2X2/3 receptors contributes to inflammatory nociception in different models, including the formalin injected in subcutaneous tissue of the rat"s hind paw.	Formaldehyde	161-169	purinergic receptor P2X 3	Rattus norvegicus	60-64
24120766-2	2013	In this study, we have evaluated whether TRPA1, 5-HT3 and 5-HT1A receptors, whose activation is essential to formalin-induced inflammatory nociception, are involved in the nociception induced by activation of P2X3 receptors on subcutaneous tissue of the rat"s hind paw.	Formaldehyde	109-117	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	41-46
24120766-2	2013	In this study, we have evaluated whether TRPA1, 5-HT3 and 5-HT1A receptors, whose activation is essential to formalin-induced inflammatory nociception, are involved in the nociception induced by activation of P2X3 receptors on subcutaneous tissue of the rat"s hind paw.	Formaldehyde	109-117	5-hydroxytryptamine receptor 1A	Rattus norvegicus	58-64
24120766-2	2013	In this study, we have evaluated whether TRPA1, 5-HT3 and 5-HT1A receptors, whose activation is essential to formalin-induced inflammatory nociception, are involved in the nociception induced by activation of P2X3 receptors on subcutaneous tissue of the rat"s hind paw.	Formaldehyde	109-117	purinergic receptor P2X 3	Rattus norvegicus	209-213
24120766-3	2013	We have also evaluated whether the activation of P2X3 receptors increases the susceptibility of primary afferent neurons to formalin action modulated by activation of TRPA1, 5-HT3 or 5-HT1A receptors.	Formaldehyde	124-132	purinergic receptor P2X 3	Rattus norvegicus	49-53
24120766-3	2013	We have also evaluated whether the activation of P2X3 receptors increases the susceptibility of primary afferent neurons to formalin action modulated by activation of TRPA1, 5-HT3 or 5-HT1A receptors.	Formaldehyde	124-132	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	167-172
24120766-6	2013	Administration of the selective P2X3 and P2X2/3 receptor antagonist A-317491 or pretreatment with oligonucleotides antisense against P2X3 receptor prevented the formalin-induced behavioral nociceptive responses during the first and second phases.	Formaldehyde	161-169	purinergic receptor P2X 3	Rattus norvegicus	32-36
24120766-6	2013	Administration of the selective P2X3 and P2X2/3 receptor antagonist A-317491 or pretreatment with oligonucleotides antisense against P2X3 receptor prevented the formalin-induced behavioral nociceptive responses during the first and second phases.	Formaldehyde	161-169	purinergic receptor P2X 3	Rattus norvegicus	41-47
24120766-6	2013	Administration of the selective P2X3 and P2X2/3 receptor antagonist A-317491 or pretreatment with oligonucleotides antisense against P2X3 receptor prevented the formalin-induced behavioral nociceptive responses during the first and second phases.	Formaldehyde	161-169	purinergic receptor P2X 3	Rattus norvegicus	133-137
24125787-0	2013	Orexin receptor type-1 antagonist SB-334867 decreases morphine-induced antinociceptive effect in formalin test.	Formaldehyde	97-105	hypocretin receptor 1	Rattus norvegicus	0-22
24250750-5	2013	Formaldehyde-assisted isolation of regulatory elements sequencing analysis of the whole CXCL cluster demonstrated 1,25(OH)2D3-dependent chromatin opening exclusively for the VDR binding site.	Formaldehyde	0-12	vitamin D receptor	Homo sapiens	174-177
24172941-3	2013	Using behavioral testing, we found that TRPA1 knockout mice failed to avoid entering a chamber filled with vapor of formalin, allyl isothiocyanate, and acrolein.	Formaldehyde	116-124	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	40-45
24172941-6	2013	Additionally, the spinal trigeminal nucleus, the first relay neurons of the trigeminal system, showed massive expression of c-Fos after a brief (3 min) exposure to formalin vapor.	Formaldehyde	164-172	FBJ osteosarcoma oncogene	Mus musculus	124-129
24050112-6	2013	Interestingly, 19 (3 mg/kg, ip, and 30 mg/kg, po) caused significant attenuation of formalin-induced behavior in early and late phases of the mouse intradermal formalin test of pain, and this in vivo effect was reversed by the selective 5-HT1AR antagonist WAY-100635.	Formaldehyde	84-92	5-hydroxytryptamine receptor 1A	Homo sapiens	237-244
24301760-2	2013	In this study, a BRAF V600E mutation was detected in formalin-fixed and paraffin-embedded PTC samples using multiplex allele-specific polymerase chain reaction and denaturing high-performance liquid chromatography.	Formaldehyde	53-61	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	17-21
23641685-1	2013	We report vibrational and electronic spectra of the hydroxy-methyl-peroxy radical (HOCH2OO( ) or HMP), which was formed as the primary product of the reaction of the hydroperoxy radical, HO2( ), and formaldehyde, HCHO.	Formaldehyde	199-211	inner membrane mitochondrial protein	Homo sapiens	97-100
23830907-8	2013	Contrariwise, hydroxylamine (HA, a CBS inhibitor) and DL-propargylglycine (PPG, a CSE inhibitor) decreased formalin-induced nociceptive behavior in both experimental groups.	Formaldehyde	107-115	cystathionine gamma-lyase	Rattus norvegicus	82-85
23830907-14	2013	Collectively, results suggest that H2S synthesized by CBS and CSE participate in formalin-induced nociception in diabetic and non-diabetic rats, as well as; in tactile allodynia in streptozotocin-injected rats.	Formaldehyde	81-89	cystathionine gamma-lyase	Rattus norvegicus	62-65
23641685-1	2013	We report vibrational and electronic spectra of the hydroxy-methyl-peroxy radical (HOCH2OO( ) or HMP), which was formed as the primary product of the reaction of the hydroperoxy radical, HO2( ), and formaldehyde, HCHO.	Formaldehyde	199-211	heme oxygenase 2	Homo sapiens	187-190
23652586-5	2013	The expression of DcR3 and survivin were analyzed by immunohistochemistry on formalin-fixed paraffin-embedded lymph node sections from 80 cases of B cell NHL and 15 controls.	Formaldehyde	77-85	TNF receptor superfamily member 6b	Homo sapiens	18-22
24457237-5	2013	Molecular analysis by DNA direct sequencing was performed to detect EGFR mutations on formalin-fixated tissue mostly from surgically resected tumors.	Formaldehyde	86-94	epidermal growth factor receptor	Homo sapiens	68-72
23644682-4	2013	EGFR mutations were analyzed by DNA sequencing in 24 cases with formalin-fixed paraffin-embedded blocks.	Formaldehyde	64-72	epidermal growth factor receptor	Homo sapiens	0-4
23800365-7	2013	Although moderate concentrations of formaldehyde are not acutely toxic for brain cells, exposure to formaldehyde severely affects their metabolism as demonstrated by the formaldehyde-induced acceleration of glycolytic flux and by the rapid multidrug resistance protein 1-mediated export of glutathione from both astrocytes and neurons.	Formaldehyde	36-48	ATP binding cassette subfamily B member 1	Homo sapiens	240-270
23800365-7	2013	Although moderate concentrations of formaldehyde are not acutely toxic for brain cells, exposure to formaldehyde severely affects their metabolism as demonstrated by the formaldehyde-induced acceleration of glycolytic flux and by the rapid multidrug resistance protein 1-mediated export of glutathione from both astrocytes and neurons.	Formaldehyde	100-112	ATP binding cassette subfamily B member 1	Homo sapiens	240-270
23800365-7	2013	Although moderate concentrations of formaldehyde are not acutely toxic for brain cells, exposure to formaldehyde severely affects their metabolism as demonstrated by the formaldehyde-induced acceleration of glycolytic flux and by the rapid multidrug resistance protein 1-mediated export of glutathione from both astrocytes and neurons.	Formaldehyde	100-112	ATP binding cassette subfamily B member 1	Homo sapiens	240-270
23447357-12	2013	In summary, formalin fixation from 2 to 96 hours and preparation of cells as cell blocks produces optimal results for ER, PR, and HER-2 testing in human breast cancer cells.	Formaldehyde	12-20	erb-b2 receptor tyrosine kinase 2	Homo sapiens	130-135
23946162-3	2013	The Pictet-Spengler reaction of Trp and [(11)C]formaldehyde in acidic media (TsOH or HCl) afforded the desired [1-(11)C]Tpi in a moderate radiochemical yield.	Formaldehyde	47-59	triosephosphate isomerase 1	Homo sapiens	120-123
23744981-3	2013	Formalin-fixed paraffin embedded samples were analyzed for BRMS1 methylation status using methylation-specific PCR in a human specimen cohort consisting of noncancerous tissues, benign fibroadenomas, and primary breast tumors, including some with adjacent noncancerous tissues.	Formaldehyde	0-8	BRMS1 transcriptional repressor and anoikis regulator	Homo sapiens	59-64
23773262-3	2013	MATERIALS AND METHODS: Copy number variation of the 19q13.3 region carrying the ERCC1 gene, classified as gene amplification (GA) or high polysomy (HP), was evaluated on 235 formalin-fixed and paraffin-embedded tumors from resected NSCLC patient samples and 16 NSCLC cell lines using FISH.	Formaldehyde	174-182	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	80-85
23911581-3	2013	We investigated here if two such compounds, the FAAH/TRPV1 blocker OMDM198 and the FAAH inhibitor/TRPA1 agonist, OMDM202, exert anti-nociceptive actions in the formalin test of pain in mice, and through what mechanism.	Formaldehyde	160-168	fatty acid amide hydrolase	Mus musculus	48-52
23911581-3	2013	We investigated here if two such compounds, the FAAH/TRPV1 blocker OMDM198 and the FAAH inhibitor/TRPA1 agonist, OMDM202, exert anti-nociceptive actions in the formalin test of pain in mice, and through what mechanism.	Formaldehyde	160-168	fatty acid amide hydrolase	Mus musculus	83-87
23911581-3	2013	We investigated here if two such compounds, the FAAH/TRPV1 blocker OMDM198 and the FAAH inhibitor/TRPA1 agonist, OMDM202, exert anti-nociceptive actions in the formalin test of pain in mice, and through what mechanism.	Formaldehyde	160-168	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	98-103
24075004-0	2013	TRK-380, a novel selective human beta3-adrenoceptor agonist, ameliorates formalin-induced pollakiuria in rats and carbachol-induced bladder contraction in dogs.	Formaldehyde	73-81	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	0-3
24075004-0	2013	TRK-380, a novel selective human beta3-adrenoceptor agonist, ameliorates formalin-induced pollakiuria in rats and carbachol-induced bladder contraction in dogs.	Formaldehyde	73-81	adrenoceptor beta 3	Homo sapiens	33-51
24075004-6	2013	RESULTS: Rats treated with formalin showed a significant increase in the voiding frequency compared with the sham group, and the increase in it was significantly and dose-dependently suppressed by TRK-380 at doses of &gt;=15 mg/kg.	Formaldehyde	27-35	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	197-200
24098676-11	2013	Thus, in the rat formalin model, the balance between norepinephrine and serotonin transporter inhibition influences the degree of antinociceptive synergy observed between monoamine reuptake inhibitors and morphine.	Formaldehyde	17-25	solute carrier family 6 member 4	Rattus norvegicus	72-93
23939287-0	2013	Intrathecal adrenomedullin modulates acute inflammatory pain in the rat formalin test.	Formaldehyde	72-80	adrenomedullin	Rattus norvegicus	12-26
23939287-2	2013	This study was undertaken to investigate the role of AM in acute inflammatory pain induced by formalin injection in rats.	Formaldehyde	94-102	adrenomedullin	Rattus norvegicus	53-55
23939287-3	2013	Interestingly Cerebrospinal fluid (CSF) levels of AM increased 45 min after formalin injection and a selective AM receptor antagonist, AM22-52, administered intrathecally (i.t.)	Formaldehyde	76-84	adrenomedullin	Rattus norvegicus	50-52
23946533-8	2013	Stage identification by way of IHC for acrosin appeared possible for tissue fixed in formalin, Bouin fixative, diluted Bouin fixative, Cleland fluid, and modified Davidson fixative, indicating a wide applicability.	Formaldehyde	85-93	acrosin	Homo sapiens	39-46
24066029-3	2013	In this report, we used a multispectral quantum dot labeling technique to label six RANK and c-Met convergent signaling pathway mediators simultaneously in formalin fixed paraffin embedded (FFPE) tissue specimens, quantify the intensity of each expression at the sub-cellular level, and investigated their potential utility as predictors of patient survival in Caucasian-American, African-American and Chinese men.	Formaldehyde	156-164	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	93-98
24039846-3	2013	DESIGN: MiR-21 expression was evaluated in formalin-fixed paraffin-embedded samples from patients with esophageal squamous-cell carcinoma (SCC) by quantitative RT-PCR.	Formaldehyde	43-51	microRNA 21	Homo sapiens	8-14
24004843-7	2013	Blockade of mGluR7 within the VL PAG has an antinociceptive effect in formalin and neuropathic pain models.	Formaldehyde	70-78	glutamate receptor, ionotropic, kainate 3	Mus musculus	12-18
23867467-2	2013	Formalin-induced responses were evaluated 24h after an IL-1beta injection.	Formaldehyde	0-8	interleukin 1 beta	Rattus norvegicus	55-63
23867467-3	2013	A subcutaneous injection of 10ng of IL-1beta elevated the formalin-induced scratching response significantly in the second phase compared to the vehicle-treated group.	Formaldehyde	58-66	interleukin 1 beta	Rattus norvegicus	36-44
23867467-5	2013	Pretreatment with IL-1beta increased the p-ERK and p-p38 expression induced by the formalin injection.	Formaldehyde	83-91	interleukin 1 beta	Rattus norvegicus	18-26
23867467-5	2013	Pretreatment with IL-1beta increased the p-ERK and p-p38 expression induced by the formalin injection.	Formaldehyde	83-91	mitogen activated protein kinase 14	Rattus norvegicus	53-56
23867467-7	2013	The intracisternal administration of minocycline (50mug), a microglia inhibitor, attenuated the increased formalin-induced scratching responses in the IL-1beta-treated rats.	Formaldehyde	106-114	interleukin 1 beta	Rattus norvegicus	151-159
23867467-8	2013	The intracisternal administration of PD98059 (1, 10mug), a MEK inhibitor, and SB203580 (1, 5mug), a p38 inhibitor, also attenuated the number of formalin-induced scratches in the second phase in the IL-1beta-treated rats.	Formaldehyde	145-153	interleukin 1 beta	Rattus norvegicus	199-207
24086281-7	2013	Here we report an assay based on a rabbit monoclonal antibody that can reliably detect endogenous LKB1 protein (and its absence) in mouse and human formalin-fixed, paraffin-embedded tissues.	Formaldehyde	148-156	serine/threonine kinase 11	Mus musculus	98-102
24086281-9	2013	Our studies fully validate this immunohistochemical assay for LKB1 in paraffin-embedded formalin tissue sections.	Formaldehyde	88-96	serine/threonine kinase 11	Homo sapiens	62-66
23981156-0	2013	PCR-based clonality analysis in diffuse large B-cell lymphoma using BIOMED-2 primers of IgH (FR3) on formalin-fixed paraffin-embedded tissue.	Formaldehyde	101-109	immunoglobulin heavy locus	Homo sapiens	88-91
23688911-6	2013	RESULTS: Immunohistochemistry (1:1000 antibody dilution) on formalin-fixed material showed a reduced signal for JUP in 7/10 AC patients in a bidirectional, double-blinded exchange experiment in which 77% of individuals were correctly classified.	Formaldehyde	60-68	junction plakoglobin	Homo sapiens	112-115
23349076-1	2013	BACKGROUND: Previous studies have identified neuromedin U receptor 2 (NMUR2) as the subtype mediating the effects of neuromedin U on acute chemo-nociception induced by capsaicin or formalin injection.	Formaldehyde	181-189	neuromedin U receptor 2	Mus musculus	45-68
23349076-1	2013	BACKGROUND: Previous studies have identified neuromedin U receptor 2 (NMUR2) as the subtype mediating the effects of neuromedin U on acute chemo-nociception induced by capsaicin or formalin injection.	Formaldehyde	181-189	neuromedin U receptor 2	Mus musculus	70-75
23349076-1	2013	BACKGROUND: Previous studies have identified neuromedin U receptor 2 (NMUR2) as the subtype mediating the effects of neuromedin U on acute chemo-nociception induced by capsaicin or formalin injection.	Formaldehyde	181-189	neuromedin U	Mus musculus	45-57
23618693-2	2013	DNA from macrodissected tumour samples of formalin fixed biopsies was used for PCR amplification of EGFR exons 18, 19, 21 and KRAS exon 1.	Formaldehyde	42-50	epidermal growth factor receptor	Homo sapiens	100-104
23528046-0	2013	Gene silencing of NR2B-containing NMDA receptor by intrathecal injection of short hairpin RNA reduces formalin-induced nociception in C57BL/6 mouse.	Formaldehyde	102-110	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	18-22
23528046-4	2013	In the present study, we investigated whether intrathecal injection of shRNAs targeting NR2B (GRIN2B shRNA) could affect nociception on formalin-induced pain in mice.	Formaldehyde	136-144	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	88-92
23528046-4	2013	In the present study, we investigated whether intrathecal injection of shRNAs targeting NR2B (GRIN2B shRNA) could affect nociception on formalin-induced pain in mice.	Formaldehyde	136-144	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	94-100
23528046-5	2013	Our results showed that intrathecal injection of GRIN2B shRNA could decrease NR2B mRNA and protein expression levels and hence effectively relieve formalin-induced nociception in mice, suggesting that intrathecal delivery of GRIN2B shRNA can be an efficient way to silence the target gene and provide new insights into the treatment of chronic pain.	Formaldehyde	147-155	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	49-55
23528046-5	2013	Our results showed that intrathecal injection of GRIN2B shRNA could decrease NR2B mRNA and protein expression levels and hence effectively relieve formalin-induced nociception in mice, suggesting that intrathecal delivery of GRIN2B shRNA can be an efficient way to silence the target gene and provide new insights into the treatment of chronic pain.	Formaldehyde	147-155	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	225-231
23727348-0	2013	Detection of truncated HER2 forms in formalin-fixed, paraffin-embedded breast cancer tissue captures heterogeneity and is not affected by HER2-targeted therapy.	Formaldehyde	37-45	erb-b2 receptor tyrosine kinase 2	Homo sapiens	23-27
23786569-6	2013	In addition, we found that inhibiting GluK1-containing KA receptors in the ACC also reduced behavioral nociceptive responses induced by formalin.	Formaldehyde	136-144	glutamate receptor, ionotropic, kainate 1	Mus musculus	38-43
23727000-5	2013	The immunisation of poultry with a formaldehyde NetB toxoid or with a NetB genetic toxoid (W262A) resulted in the induction of antibody responses against NetB and provided partial protection against disease.	Formaldehyde	35-47	netB	Clostridium perfringens	48-52
23977449-4	2013	A novel in situ hybridization method (RNAscope) was used to determine the transcript level of two relatively low expressed genes, CD44 and EpCAM in both individual formalin-fixed paraffin-embedded (FFPE) tissue sections and in an ESCC tissue microarray (TMA).	Formaldehyde	164-172	CD44 molecule (Indian blood group)	Homo sapiens	130-134
23977449-4	2013	A novel in situ hybridization method (RNAscope) was used to determine the transcript level of two relatively low expressed genes, CD44 and EpCAM in both individual formalin-fixed paraffin-embedded (FFPE) tissue sections and in an ESCC tissue microarray (TMA).	Formaldehyde	164-172	epithelial cell adhesion molecule	Homo sapiens	139-144
23959396-4	2013	Using the VeraTag  assay platform, we developed a dual antibody proximity-based assay for the precise quantitation of HER3 total protein (H3T) from formalin-fixed paraffin-embedded (FFPE) breast tumors.	Formaldehyde	148-156	H3.4 histone	Homo sapiens	118-141
23628704-8	2013	Significant accumulation of glycogen synthase kinase-3beta (GSK-3beta) in the nucleus of N2a and mouse brain cells, and elevation of its phosphorylation at Y216, was observed under formaldehyde stress.	Formaldehyde	181-193	glycogen synthase kinase 3 beta	Mus musculus	28-58
23628704-8	2013	Significant accumulation of glycogen synthase kinase-3beta (GSK-3beta) in the nucleus of N2a and mouse brain cells, and elevation of its phosphorylation at Y216, was observed under formaldehyde stress.	Formaldehyde	181-193	glycogen synthase kinase 3 beta	Mus musculus	60-69
23628704-9	2013	Formaldehyde-induced Tau hyperphosphorylation was blocked in the presence of LiCl and CT99021, inhibitors of GSK-3beta, and by RNAi interference.	Formaldehyde	0-12	glycogen synthase kinase 3 beta	Mus musculus	109-118
23628704-10	2013	CONCLUSIONS: Formaldehyde, which may cause age-related memory loss, can act as a factor triggering Tau hyperphosphorylation via GSK-3beta catalysis and induces polymerization of Tau.	Formaldehyde	13-25	glycogen synthase kinase 3 beta	Mus musculus	128-137
23708866-7	2013	RESULTS: Intraplantar formalin-induced robust neurokinin 1 receptor internalization in ipsilateral dorsal horn (ipsilateral: 54 +- 6% [mean +- SEM], contralateral: 12 +- 2%; P &lt; 0.05; n = 4).	Formaldehyde	22-30	tachykinin receptor 1	Rattus norvegicus	46-67
23516071-5	2013	Formalin-fixed paraffin-embedded tissue sections were stained for ss-catenin, cyclooxygenase-2 (Cox-2), and p53 and scored.	Formaldehyde	0-8	prostaglandin-endoperoxide synthase 2	Homo sapiens	78-94
23516071-5	2013	Formalin-fixed paraffin-embedded tissue sections were stained for ss-catenin, cyclooxygenase-2 (Cox-2), and p53 and scored.	Formaldehyde	0-8	prostaglandin-endoperoxide synthase 2	Homo sapiens	96-101
23484491-6	2013	DNA damage was further quantified in keratinocytes by immunofluorescence staining of gamma-histone 2AX (gamma-H2AX) foci in formalin-fixed skin harvested 1 hour or 1 day post-whole body irradiation.	Formaldehyde	124-132	H2A.X variant histone	Mus musculus	85-102
23484491-6	2013	DNA damage was further quantified in keratinocytes by immunofluorescence staining of gamma-histone 2AX (gamma-H2AX) foci in formalin-fixed skin harvested 1 hour or 1 day post-whole body irradiation.	Formaldehyde	124-132	H2A.X variant histone	Mus musculus	104-114
24009630-0	2013	Comparison of Three BRAF Mutation Tests in Formalin-Fixed Paraffin Embedded Clinical Samples.	Formaldehyde	43-51	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	20-24
23557458-1	2013	OBJECTIVE: The dual actions of S-nitrosoglutathione reductase comprise reduction of S-nitrosoglutathione, a potent endogenous airway smooth muscle relaxant that is depleted in asthmatics, and detoxification of formaldehyde to formate.	Formaldehyde	210-222	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	31-61
23743605-5	2013	We investigated 37 cases with hypopharyngeal squamous cell carcinoma, determined REG mRNA expression, which is easily detected in formalin-fixed paraffin-embedded tissues using the real-time reverse transcriptase-polymerase chain reaction method, and evaluated the survival rate using the Kaplan-Meier method.	Formaldehyde	130-138	regenerating family member 1 alpha	Homo sapiens	81-84
23909422-6	2013	In addition, M3H9 MAb can detect the expression of the MuD protein in formalin-fixed, paraffin-embedded mouse ovary and uterus tissues.	Formaldehyde	70-78	adaptor-related protein complex 5, mu 1 subunit	Mus musculus	55-58
23515934-4	2013	In addition, the cumulative nociceptive response time for intraplantar formalin injection (2nd phase), intrathecal injection of substance P (0.7 mug) or glutamate (20 mug) was diminished by oleanolic acid.	Formaldehyde	71-79	tachykinin 1	Mus musculus	128-139
23819652-3	2013	Next, we decided to expand the LipB gene expression analysis to a further 48 ovarian carcinoma samples, for a total of 101 tumor tissues of various histologies and to study its protein expression by immunohistochemistry in formalin-fixed paraffin-embedded tumors and normal ovaries.	Formaldehyde	223-231	lipase B, lysosomal acid type	Homo sapiens	31-35
23883275-14	2013	CONCLUSIONS: STA fragment analysis is a simple and sensitive method to detect BRAF V600 mutations in formalin-fixed paraffin-embedded clinical samples.	Formaldehyde	101-109	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	78-82
22382760-6	2013	Chronic excess formaldehyde treatment over a period of 30 days markedly decreased the viability of the hippocampus and down-regulated the expression of the NR1 and NR2B subunits of the NMDA receptor.	Formaldehyde	15-27	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	156-159
23554136-7	2013	Immunohistochemical analysis of the formalin-fixed middle colons showed that YMT and mate saponins reduced the expression of p-p65(ser311) by 45.7% and 43.1%, respectively, in comparison to the control (P &lt; 0.05).	Formaldehyde	36-44	synaptotagmin 1	Rattus norvegicus	127-130
22362219-2	2013	In this study, we aimed to analyze the expression levels of Ki67 (MKI67) messenger RNA (mRNA) derived from formalin-fixed paraffin-embedded (FFPE) tissues for comparison with the immunohistochemical Ki67 labeling index, and investigate the correlation coefficients with clinical outcomes.	Formaldehyde	107-115	marker of proliferation Ki-67	Homo sapiens	66-71
22807465-1	2013	The use of formalin-fixed cell blocks (CBs) for detection of ER, PR, and Her2 status of primary and metastatic breast carcinomas sampled by fine-needle aspiration (FNA) has been extensively used in clinical practice; however, CBs sometimes lack adequate cellularity even when direct smears are cellular.	Formaldehyde	11-19	erb-b2 receptor tyrosine kinase 2	Homo sapiens	73-77
23660872-5	2013	miRNA expression profiles were validated in an independent series of 30 composed of VHL-, SDHB-, SDHD-, and RET-related formalin-fixed paraffin-embedded PCC/PGL samples using quantitative real-time PCR.	Formaldehyde	120-128	ret proto-oncogene	Rattus norvegicus	108-111
23826410-4	2013	Expression of the lysosomal marker LAMP-1 (lysosomal-associated membrane protein-1) was investigated by immunohistochemistry in 112 formalin fixed paraffin embedded astrocytomas and compared with tumor grade and overall patient survival.	Formaldehyde	132-140	lysosomal associated membrane protein 1	Homo sapiens	35-41
23826410-4	2013	Expression of the lysosomal marker LAMP-1 (lysosomal-associated membrane protein-1) was investigated by immunohistochemistry in 112 formalin fixed paraffin embedded astrocytomas and compared with tumor grade and overall patient survival.	Formaldehyde	132-140	lysosomal associated membrane protein 1	Homo sapiens	43-82
23235345-3	2013	METHODS: We investigated BRAF V600E expression in formalin-fixed and paraffin-embedded surgical tissue specimens of 20 immunocompetent patients with PCNSL using the mutation-specific monoclonal mouse antibody VE1.	Formaldehyde	50-58	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	25-29
24061459-13	2013	This method is simple and cost effective and can easily be done in formaline-fixed paraffin embedded tissues in a clinical laboratory for grading CIN and SCC lesions in cervix.	Formaldehyde	67-76	serpin family B member 3	Homo sapiens	154-157
23778145-9	2013	SNS-Nedd4L(-/-) mice exhibited thermal hypersensitivity and an enhanced second pain phase after formalin injection.	Formaldehyde	96-104	neural precursor cell expressed, developmentally down-regulated gene 4-like	Mus musculus	4-10
23861999-0	2013	The Effects of Pre-emptive Administration of Ketamine and norBNI on Pain Behavior, c-Fos, and Prodynorphin Protein Expression in the Rat Spinal Cord after Formalin-induced Pain Is Modulated by the DREAM Protein.	Formaldehyde	155-163	potassium voltage-gated channel interacting protein 3	Rattus norvegicus	197-202
23861999-10	2013	CONCLUSIONS: We suggest that NMDA and kappa opioid receptors can modulate DREAM protein expression, which can affect pain behavior and protein transcriptional processes at 2 hours and bring about either harmful or protective effects at 4 hours after formalin injection.	Formaldehyde	250-258	potassium voltage-gated channel interacting protein 3	Rattus norvegicus	74-79
24019826-5	2013	Due to limited number of studies on DNMT3B promoter methylation, this study was performed to quantitatively measure the methylation level of DNMT3B gene in archival formalin fixed paraffin embedded (FFPE) tissues from breast cancer patients.	Formaldehyde	165-173	DNA methyltransferase 3 beta	Homo sapiens	141-147
23523996-0	2013	Interleukin-33 mediates formalin-induced inflammatory pain in mice.	Formaldehyde	24-32	interleukin 33	Mus musculus	0-14
23523996-4	2013	The present study was designed to explore the possible roles of IL-33 and its receptor, ST2, in formalin-induced inflammatory pain in mice.	Formaldehyde	96-104	interleukin 33	Mus musculus	64-69
23523996-4	2013	The present study was designed to explore the possible roles of IL-33 and its receptor, ST2, in formalin-induced inflammatory pain in mice.	Formaldehyde	96-104	interleukin 1 receptor-like 1	Mus musculus	88-91
23523996-5	2013	We found that both subcutaneous (s.c., 300 ng) and intrathecal injection (i.t., 3 ng) of recombinant IL-33 (rIL-33) increased paw lifting and licking time not only in normal mice but also in formalin models.	Formaldehyde	191-199	interleukin 33	Mus musculus	101-106
23523996-5	2013	We found that both subcutaneous (s.c., 300 ng) and intrathecal injection (i.t., 3 ng) of recombinant IL-33 (rIL-33) increased paw lifting and licking time not only in normal mice but also in formalin models.	Formaldehyde	191-199	interleukin 33	Rattus norvegicus	108-114
23523996-6	2013	Administration of ST2 antibody, which blocked the IL-33/ST2 signaling, alleviated the formalin-induced spontaneous pain behavior.	Formaldehyde	86-94	interleukin 1 receptor-like 1	Mus musculus	18-21
23523996-6	2013	Administration of ST2 antibody, which blocked the IL-33/ST2 signaling, alleviated the formalin-induced spontaneous pain behavior.	Formaldehyde	86-94	interleukin 33	Mus musculus	50-55
23523996-6	2013	Administration of ST2 antibody, which blocked the IL-33/ST2 signaling, alleviated the formalin-induced spontaneous pain behavior.	Formaldehyde	86-94	interleukin 1 receptor-like 1	Mus musculus	56-59
23523996-7	2013	Moreover, the ST2(-/-) mice showed significantly decreased pain behavior, as well as reduced ultrasonic vocalization induced by formalin, compared with the wild-type group.	Formaldehyde	128-136	interleukin 1 receptor-like 1	Mus musculus	14-17
23523996-8	2013	Additionally, ST2 antibody alleviated the potentiating effects of rIL-33 on pain behavior in the formalin mice, indicating that IL-33 plays a role in pain modulation through its ST2 receptor.	Formaldehyde	97-105	interleukin 1 receptor-like 1	Mus musculus	14-17
23523996-8	2013	Additionally, ST2 antibody alleviated the potentiating effects of rIL-33 on pain behavior in the formalin mice, indicating that IL-33 plays a role in pain modulation through its ST2 receptor.	Formaldehyde	97-105	interleukin 33	Rattus norvegicus	66-72
23523996-8	2013	Additionally, ST2 antibody alleviated the potentiating effects of rIL-33 on pain behavior in the formalin mice, indicating that IL-33 plays a role in pain modulation through its ST2 receptor.	Formaldehyde	97-105	interleukin 33	Mus musculus	67-72
23523996-8	2013	Additionally, ST2 antibody alleviated the potentiating effects of rIL-33 on pain behavior in the formalin mice, indicating that IL-33 plays a role in pain modulation through its ST2 receptor.	Formaldehyde	97-105	interleukin 1 receptor-like 1	Mus musculus	178-181
23523996-9	2013	These data suggest IL-33 and its ST2 receptor mediate formalin-induced inflammatory pain, and as a result this cytokine and its receptor may be new targets for the development of analgesics.	Formaldehyde	54-62	interleukin 33	Mus musculus	19-24
23523996-9	2013	These data suggest IL-33 and its ST2 receptor mediate formalin-induced inflammatory pain, and as a result this cytokine and its receptor may be new targets for the development of analgesics.	Formaldehyde	54-62	interleukin 1 receptor-like 1	Mus musculus	33-36
23583574-0	2013	Role of 5-HT1B/1D receptors in the reduction of formalin-induced nociception and secondary allodynia/hyperalgesia produced by antimigraine drugs in rats.	Formaldehyde	48-56	5-hydroxytryptamine receptor 1B	Rattus norvegicus	8-14
23583574-10	2013	SIGNIFICANCE: The above findings suggest that: (i) the antimigraine drugs sumatriptan, methysergide and dihydroergotamine reduce the acute and chronic nociception induced by formalin; and (ii) this antinociceptive effect results from activation of peripheral 5-HT1B/1D serotonergic receptors.	Formaldehyde	174-182	5-hydroxytryptamine receptor 1B	Rattus norvegicus	259-265
22382760-6	2013	Chronic excess formaldehyde treatment over a period of 30 days markedly decreased the viability of the hippocampus and down-regulated the expression of the NR1 and NR2B subunits of the NMDA receptor.	Formaldehyde	15-27	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	164-168
23358413-0	2013	Droplet digital PCR measurement of HER2 copy number alteration in formalin-fixed paraffin-embedded breast carcinoma tissue.	Formaldehyde	66-74	erb-b2 receptor tyrosine kinase 2	Homo sapiens	35-39
23582793-4	2013	The expression of c-FLIP was analyzed using the standard imunohistochemical method on formalin-fixed and routinely processed paraffin-embedded lymph node specimens and evaluated semi quantitavely as a percentage of tumor cells.	Formaldehyde	86-94	CASP8 and FADD like apoptosis regulator	Homo sapiens	18-24
23592755-2	2013	In this report, we surveyed 924 miRNA (miR) for their expressions in the formalin-fixed paraffin-embedded specimens from 42 patients with SCLC, and found that the downregulated miR-886-3p is closely correlated with the shorter survival of SCLC.	Formaldehyde	73-81	vault RNA 2-1	Homo sapiens	177-184
23269354-2	2013	METHODS: The expression of E-cadherin was analysed immunohistochemically in formalin-fixed, paraffin-embedded samples from 54 patients with advanced-stage serous ovarian cancer and related to clinicopathological characteristics and patients survival.	Formaldehyde	76-84	cadherin 1	Homo sapiens	27-37
23825889-5	2013	Immunohistochemistry for CD10 was performed on the sections obtained from formalin-fixed, paraffin-embedded blocks.	Formaldehyde	74-82	membrane metalloendopeptidase	Homo sapiens	25-29
23260326-5	2013	Using quantitative real-time reverse transcription-polymerase chain reaction, we analyzed miR-16 expression level in archived formalin-fixed and paraffin-embedded diagnostic lymph node specimens from a total of 72 patients with T-lymphoblastic lymphoma/leukemia and for which clinical follow-up information was available.	Formaldehyde	126-134	glycerophosphodiester phosphodiesterase 1	Homo sapiens	90-96
23560708-4	2013	METHODS: Screw fixation was performed on 16 formalin-fixed human C-2 dens specimens.	Formaldehyde	44-52	complement C2	Homo sapiens	65-68
23494125-3	2013	Pain sensitivity thresholds in animals treated with LPP1 were established using 5 % formalin solution in normoglycemic mice and in streptozotocin (STZ)-treated diabetic mice in the von Frey, hot plate, innocuous, and noxious cold water tests (water at 10  C and 4  C, respectively).	Formaldehyde	84-92	phospholipid phosphatase 1	Mus musculus	52-56
23229351-4	2013	When the selective pulses are offset on the CH2O resonances, the homonuclear couplings between the NCH2 and CH2O protons are effectively removed, and the spectrum of PME and PDE is significantly enhanced.	Formaldehyde	44-48	cystatin B	Homo sapiens	166-169
23229351-4	2013	When the selective pulses are offset on the CH2O resonances, the homonuclear couplings between the NCH2 and CH2O protons are effectively removed, and the spectrum of PME and PDE is significantly enhanced.	Formaldehyde	44-48	aldehyde dehydrogenase 7 family member A1	Homo sapiens	174-177
23229351-4	2013	When the selective pulses are offset on the CH2O resonances, the homonuclear couplings between the NCH2 and CH2O protons are effectively removed, and the spectrum of PME and PDE is significantly enhanced.	Formaldehyde	108-112	cystatin B	Homo sapiens	166-169
23229351-4	2013	When the selective pulses are offset on the CH2O resonances, the homonuclear couplings between the NCH2 and CH2O protons are effectively removed, and the spectrum of PME and PDE is significantly enhanced.	Formaldehyde	108-112	aldehyde dehydrogenase 7 family member A1	Homo sapiens	174-177
23579488-5	2013	SULT2B was detected in formalin-fixed specimens by immunohistochemistry on individual sections and tissue array.	Formaldehyde	23-31	sulfotransferase family, cytosolic, 2B, member 1	Mus musculus	0-6
23578956-7	2013	However, Nf1+- mice exhibited an attenuated first phase of formalin-induced spontaneous behavior and expedited resolution of formalin-induced heat hypersensitivity.	Formaldehyde	59-67	neurofibromin 1	Mus musculus	9-12
23578956-7	2013	However, Nf1+- mice exhibited an attenuated first phase of formalin-induced spontaneous behavior and expedited resolution of formalin-induced heat hypersensitivity.	Formaldehyde	125-133	neurofibromin 1	Mus musculus	9-12
23606169-5	2013	RESULTS: Our study showed that PTC as low as 10% was good enough to detect KRAS G12D, G13D, and Q61L mutations in formalin-fixed paraffin-embedded (FFPE) material.	Formaldehyde	114-122	KRAS proto-oncogene, GTPase	Homo sapiens	75-79
23494125-5	2013	LPP1was antinociceptive in both phases of the formalin test, in particular, in the late phase (at doses 0.9-30 mg/kg for 66-99 % vs. control normoglycemic mice) and in a statistically significant manner increased nociceptive thresholds in response to mechanical, heat, and noxious cold stimulation in neuropathic mice (at 30 mg/kg for 274, 192, and 316 %, respectively vs. diabetic control).	Formaldehyde	46-54	phospholipid phosphatase 1	Mus musculus	0-4
23494125-9	2013	LPP1 has significant antinociceptive properties in the formalin model and elevates pain thresholds in neuropathic mice.	Formaldehyde	55-63	phospholipid phosphatase 1	Mus musculus	0-4
23594689-5	2013	The most common mutation, BRAF V600E, can be detected by DNA sequencing and immunohistochemistry on formalin fixed, paraffin embedded tumour tissue.	Formaldehyde	100-108	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	26-30
23539446-5	2013	This study clarifies the prognostic value of ALCAM by visualizing ectodomain shedding using a dual stain that detects both the extracellular and the intracellular domains in formalin-fixed tissue.	Formaldehyde	174-182	activated leukocyte cell adhesion molecule	Homo sapiens	45-50
23545357-7	2013	reduced levels of TNF-alpha and IL-6 in hind paw homogenates of formalin-injected mice.	Formaldehyde	64-72	tumor necrosis factor	Mus musculus	18-27
23545357-7	2013	reduced levels of TNF-alpha and IL-6 in hind paw homogenates of formalin-injected mice.	Formaldehyde	64-72	interleukin 6	Mus musculus	32-36
23545606-2	2013	Immunohistochemical detection of HIF-1alpha and LOX protein expression was performed on formalin-fixed paraffin sections of normal ovary, benign ovarian tumors, borderline and malignant epithelial ovarian tumor paraffin sample, using Mann-Whitney U test for independent comparisons and Wilcoxon signed-ranks test for paired comparisons.	Formaldehyde	88-96	lysyl oxidase	Homo sapiens	48-51
23529657-0	2013	The kinetics behavior of the reduction of formaldehyde catalyzed by Alcohol Dehydrogenase (ADH) and partial uncompetitive substrate inhibition by NADH.	Formaldehyde	42-54	aldo-keto reductase family 1 member A1	Homo sapiens	68-89
23529657-0	2013	The kinetics behavior of the reduction of formaldehyde catalyzed by Alcohol Dehydrogenase (ADH) and partial uncompetitive substrate inhibition by NADH.	Formaldehyde	42-54	aldo-keto reductase family 1 member A1	Homo sapiens	91-94
23529657-2	2013	Here, we report the steady-state kinetics for ADH, using a homogeneous enzyme preparation with formaldehyde as the substrate and nicotinamide adenine dinucleotide (NADH) as the cofactor.	Formaldehyde	95-107	aldo-keto reductase family 1 member A1	Homo sapiens	46-49
23529657-7	2013	In the direction of formaldehyde reduction, ADH has an ordered kinetic mechanism with formaldehyde adding to enzyme first and product methanol released last.	Formaldehyde	20-32	aldo-keto reductase family 1 member A1	Homo sapiens	44-47
23529657-7	2013	In the direction of formaldehyde reduction, ADH has an ordered kinetic mechanism with formaldehyde adding to enzyme first and product methanol released last.	Formaldehyde	86-98	aldo-keto reductase family 1 member A1	Homo sapiens	44-47
23618379-7	2013	However, an formalin-fixed, paraffin- embedded (FFPE) tissue sample of the patient"s childhood Wilms tumor showed WT1- positivity restricted to the renal tumor cells, so the WT1 gene was investigated further.	Formaldehyde	12-20	WT1 transcription factor	Homo sapiens	114-117
23618379-7	2013	However, an formalin-fixed, paraffin- embedded (FFPE) tissue sample of the patient"s childhood Wilms tumor showed WT1- positivity restricted to the renal tumor cells, so the WT1 gene was investigated further.	Formaldehyde	12-20	WT1 transcription factor	Homo sapiens	174-177
23635316-4	2013	METHODS: SBEM protein expression was detected in 87 available formalin-fixed paraffin-embedded (FFPE) tissue specimens from TNBC patients by means of immunohistochemistry (IHC).	Formaldehyde	62-70	mucin like 1	Homo sapiens	9-13
23159154-0	2013	YWHAE-FAM22 endometrial stromal sarcoma: diagnosis by reverse transcription-polymerase chain reaction in formalin-fixed, paraffin-embedded tumor.	Formaldehyde	105-113	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon	Homo sapiens	0-5
23159154-4	2013	We describe here an optimized reverse transcription-polymerase chain reaction assay for detection of YWHAE-FAM22 fusion transcript in formalin-fixed and paraffin-embedded tumor samples.	Formaldehyde	134-142	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon	Homo sapiens	101-106
23159154-7	2013	The reverse transcription-polymerase chain reaction assay optimized for formalin-fixed and paraffin-embedded samples detected YWHAE-FAM22 fusion transcripts in all 6 YWHAE-FAM22 endometrial stromal sarcomas and none of the 24 non-YWHAE-FAM22 uterine sarcomas.	Formaldehyde	72-80	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon	Homo sapiens	126-131
23159154-7	2013	The reverse transcription-polymerase chain reaction assay optimized for formalin-fixed and paraffin-embedded samples detected YWHAE-FAM22 fusion transcripts in all 6 YWHAE-FAM22 endometrial stromal sarcomas and none of the 24 non-YWHAE-FAM22 uterine sarcomas.	Formaldehyde	72-80	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon	Homo sapiens	166-171
23159154-7	2013	The reverse transcription-polymerase chain reaction assay optimized for formalin-fixed and paraffin-embedded samples detected YWHAE-FAM22 fusion transcripts in all 6 YWHAE-FAM22 endometrial stromal sarcomas and none of the 24 non-YWHAE-FAM22 uterine sarcomas.	Formaldehyde	72-80	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon	Homo sapiens	166-171
23159154-8	2013	These findings show that this reverse transcription-polymerase chain reaction assay is sensitive and specific for detection of YWHAE-FAM22 fusion transcript and can serve as a useful adjunct diagnostic assay to confirm the diagnosis of YWHAE-FAM22 endometrial stromal sarcoma in formalin-fixed and paraffin-embedded tumor samples.	Formaldehyde	279-287	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon	Homo sapiens	127-132
23159154-8	2013	These findings show that this reverse transcription-polymerase chain reaction assay is sensitive and specific for detection of YWHAE-FAM22 fusion transcript and can serve as a useful adjunct diagnostic assay to confirm the diagnosis of YWHAE-FAM22 endometrial stromal sarcoma in formalin-fixed and paraffin-embedded tumor samples.	Formaldehyde	279-287	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon	Homo sapiens	236-241
23518916-4	2013	SOX2 immunoexpression was evaluated in 101 formalin-fixed, paraffin-embedded archival vulvar epithelia consisting of normal squamous vulvar epithelia (n=25), lichen sclerosus (n=9), high-grade classic vulvar intraepithelial neoplasia (HG-VIN, n=16), differentiated vulvar intraepithelial neoplasia (d-VIN, n=18), and vulvar invasive keratinizing SCC (n=33).	Formaldehyde	43-51	SRY-box transcription factor 2	Homo sapiens	0-4
23509317-7	2013	Immunohistochemical staining for HIF1/2alpha was performed on formalin-fixed, paraffin-embedded tumor tissue.	Formaldehyde	62-70	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-44
23386666-0	2013	Comparison of molecular testing methods for the detection of EGFR mutations in formalin-fixed paraffin-embedded tissue specimens of non-small cell lung cancer.	Formaldehyde	79-87	epidermal growth factor receptor	Homo sapiens	61-65
23590575-0	2013	Detection of epidermal growth factor receptor mutations in formalin fixed paraffin embedded biopsies in Malaysian non-small cell lung cancer patients.	Formaldehyde	59-67	epidermal growth factor receptor	Homo sapiens	13-45
23386666-1	2013	AIM: To conduct a methods correlation study of three different assays for the detection of mutations at EGFR gene in human formalin-fixed paraffin-embedded tumour (FFPET) specimens of non-small cell lung carcinomas (NSCLC).	Formaldehyde	123-131	epidermal growth factor receptor	Homo sapiens	104-108
23278563-4	2013	The levels and locations of syndecan-1 and -2 immunostainings were analyzed using formalin-fixed and paraffin-embedded tissue samples of OSCC and CSCC cases together with clinical data.	Formaldehyde	82-90	syndecan 1	Homo sapiens	28-45
23621958-0	2013	Analytic performance studies and clinical reproducibility of a real-time PCR assay for the detection of epidermal growth factor receptor gene mutations in formalin-fixed paraffin-embedded tissue specimens of non-small cell lung cancer.	Formaldehyde	155-163	epidermal growth factor receptor	Homo sapiens	104-136
23549827-0	2013	Effects of co-administration of intrathecal nociceptin/orphanin FQ and opioid antagonists on formalin-induced pain in rats.	Formaldehyde	93-101	prepronociceptin	Rattus norvegicus	44-54
23549827-0	2013	Effects of co-administration of intrathecal nociceptin/orphanin FQ and opioid antagonists on formalin-induced pain in rats.	Formaldehyde	93-101	prepronociceptin	Rattus norvegicus	55-66
23613636-4	2013	Formalin-fixed, paraffin-embedded tissue blocks were used to observe the protein expression of Twist2 and E-cadherin by immunohistochemistry.	Formaldehyde	0-8	twist family bHLH transcription factor 2	Homo sapiens	95-101
23590575-3	2013	The aim of this study was to detect EGFR mutations in formalin fixed paraffin embedded (FFPE) samples using both Scorpion ARMS and high resolution melt (HRM) assay, and to compare the sensitivity of these methods.	Formaldehyde	54-62	epidermal growth factor receptor	Homo sapiens	36-40
23593387-4	2013	miR-34a expression in eighty-three cases of HCC formalin-fixed paraffin-embedded (FFPE) tissues decreased significantly compared to that in the adjacent liver tissues (P&lt;0.01), as detected by real-time quantitative RT-PCR (RT-qPCR).	Formaldehyde	48-56	microRNA 34a	Homo sapiens	0-7
23564797-3	2013	MATERIALS AND METHODS: The expression of GAL-7 was determined in 63 formalin-fixed, paraffin-embedded EOC tissues using an immunohistochemical method and we compared various associated clinicopathological factors.	Formaldehyde	68-76	galectin 7	Homo sapiens	41-46
23086656-7	2013	Formalin administration induced nociception and increased tumor necrosis factor alpha (TNF-alpha) and nitric oxide (NO) levels in serum and leukocyte migration in paws.	Formaldehyde	0-8	tumor necrosis factor	Mus musculus	58-85
23161183-3	2013	Podoplanin expression was investigated immunohistochemically in 200 formalin-fixed, paraffin embedded specimens of invasive esophagal ACs, their corresponding metastases and 35 precursor lesions.	Formaldehyde	68-76	podoplanin	Homo sapiens	0-10
23084583-2	2013	In the present study, we evaluated HER2 mRNA expression using a new mRNA in situ detection technique called RNAscope in 211 cases of formalin-fixed, paraffin-embedded gastric carcinoma.	Formaldehyde	133-141	erb-b2 receptor tyrosine kinase 2	Homo sapiens	35-39
23108567-6	2013	RESULTS: KRAS mutations in codons 12 and 13 were present in 37.6 % of analyzed formalin-fixed paraffin-embedded (FFPE) DNA samples.	Formaldehyde	79-87	KRAS proto-oncogene, GTPase	Homo sapiens	9-13
23355119-0	2013	The influence of genetic polymorphisms in XRCC3 and ADH5 genes on the frequency of genotoxicity biomarkers in workers exposed to formaldehyde.	Formaldehyde	129-141	X-ray repair cross complementing 3	Homo sapiens	42-47
23355119-0	2013	The influence of genetic polymorphisms in XRCC3 and ADH5 genes on the frequency of genotoxicity biomarkers in workers exposed to formaldehyde.	Formaldehyde	129-141	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	52-56
23355119-5	2013	XRCC3 participates in DNA double-strand break/recombination repair, while ADH5 is an important component of cellular metabolism for the elimination of formaldehyde.	Formaldehyde	151-163	X-ray repair cross complementing 3	Homo sapiens	0-5
23355119-5	2013	XRCC3 participates in DNA double-strand break/recombination repair, while ADH5 is an important component of cellular metabolism for the elimination of formaldehyde.	Formaldehyde	151-163	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	74-78
23086656-7	2013	Formalin administration induced nociception and increased tumor necrosis factor alpha (TNF-alpha) and nitric oxide (NO) levels in serum and leukocyte migration in paws.	Formaldehyde	0-8	tumor necrosis factor	Mus musculus	87-96
23470198-8	2013	The inhibitory effect of complex I in the carrageenin-induced hyperalgesia, MPO activity and formalin was prevented by the treatment with ODQ, KT5823 and glybenclamide, indicating that complex I inhibits inflammatory hyperalgesia by activating the cGMP/PKG/ATP-sensitive potassium channel signaling pathway.	Formaldehyde	93-101	protein kinase cGMP-dependent 1	Homo sapiens	253-256
22218908-3	2013	METHODS: We used the polymer-based method to perform an immunohistochemistry analysis of c-Met expression on 59 formalin-fixed, paraffin-embedded sections of surgical specimens.	Formaldehyde	112-120	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	89-94
23518907-5	2013	The expression of caspase-3 was assessed immunohistochemically in formalin-fixed, paraffin-embedded tissue sections.	Formaldehyde	66-74	caspase 3	Rattus norvegicus	18-27
24498797-5	2013	Injection of different doses of ROL and carnosol reduced pain in the phase 2 of the formalin test, which was not inhibited by naloxone and/or memantine.	Formaldehyde	84-92	resistance to osmotic lysis	Mus musculus	32-35
24498797-6	2013	In addition, pretreatment of the animals with ROL and/or carnosol reduces the formalin-induced inflammation.	Formaldehyde	78-86	resistance to osmotic lysis	Mus musculus	46-49
24498797-9	2013	It could be concluded that ROL extract and carnosol suppressed pain and inflammation induced by formalin injection, which may be due to inhibition of COX1 and COX2 enzymes activity.	Formaldehyde	96-104	resistance to osmotic lysis	Mus musculus	27-30
23470198-8	2013	The inhibitory effect of complex I in the carrageenin-induced hyperalgesia, MPO activity and formalin was prevented by the treatment with ODQ, KT5823 and glybenclamide, indicating that complex I inhibits inflammatory hyperalgesia by activating the cGMP/PKG/ATP-sensitive potassium channel signaling pathway.	Formaldehyde	93-101	ATPase phospholipid transporting 8A2	Homo sapiens	257-260
23517622-3	2013	METHODS: We examined gene expression of APTX, BRCA1, ERCC1, ISG15, Topo1 and methylation of SULF2 in formalin-fixed paraffin-embedded gastric cancer tissues from 175 patients and evaluated the association between gene expression levels or methylation status and in vitro sensitivity to irinotecan.	Formaldehyde	101-109	sulfatase 2	Homo sapiens	92-97
22611048-4	2013	The aim of this study was to evaluate and to compare ER, PR and Her2 IHC results on formalin-fixed CB sections to those observed on subsequent surgical (needle core or resection) specimens (SS).	Formaldehyde	84-92	erb-b2 receptor tyrosine kinase 2	Homo sapiens	64-68
22820660-3	2013	METHODS: We immunohistochemically analyzed expression of V600E-mutant BRAF protein in archival formalin-fixed, paraffin-embedded tissue specimens of 142 epithelial ovarian tumors [98 invasive carcinomas and 44 tumors of low malignant potential (LMP)] using monoclonal antibody VE1.	Formaldehyde	95-103	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	70-74
23242143-8	2013	Moreover, LC3 stains were optimal in neutral-buffered formalin-fixed tissue, immersed in citrate buffer during antigen retrieval.	Formaldehyde	54-62	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	10-13
23307895-4	2013	We optimized a CNV detection assay based on a reporter cassette containing the SFA1 and CUP1 genes that confer gene dosage-dependent tolerance to formaldehyde and copper, respectively.	Formaldehyde	146-158	bifunctional alcohol dehydrogenase/S-(hydroxymethyl)glutathione dehydrogenase	Saccharomyces cerevisiae S288C	79-83
23370430-10	2013	In summary, we report a novel COLD-PCR/FMCA method that provides rapid and sensitive detection of IDH1 mutations in formalin-fixed paraffin-embedded tissue and can be used in the clinical setting to assess the small brain biopsies.	Formaldehyde	116-124	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	98-102
23307895-4	2013	We optimized a CNV detection assay based on a reporter cassette containing the SFA1 and CUP1 genes that confer gene dosage-dependent tolerance to formaldehyde and copper, respectively.	Formaldehyde	146-158	metallothionein CUP1	Saccharomyces cerevisiae S288C	88-92
23307895-8	2013	In addition to amplification events, a subset of clones displaying elevated resistance to formaldehyde had point mutations within the SFA1 coding sequence.	Formaldehyde	90-102	bifunctional alcohol dehydrogenase/S-(hydroxymethyl)glutathione dehydrogenase	Saccharomyces cerevisiae S288C	134-138
24649153-9	2013	As expression of miR-486 was measured from formalin-fixed paraffin-embedded (FFPE) samples, this study demonstrated that measurement of miR-486 may be readily translated into clinical applications.	Formaldehyde	43-51	microRNA 486-1	Homo sapiens	17-24
23275449-0	2013	Protein domain histochemistry (PDH): binding of the carbohydrate recognition domain (CRD) of recombinant human glycoreceptor CLEC10A (CD301) to formalin-fixed, paraffin-embedded breast cancer tissues.	Formaldehyde	144-152	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	31-34
23275449-0	2013	Protein domain histochemistry (PDH): binding of the carbohydrate recognition domain (CRD) of recombinant human glycoreceptor CLEC10A (CD301) to formalin-fixed, paraffin-embedded breast cancer tissues.	Formaldehyde	144-152	C-type lectin domain containing 10A	Homo sapiens	125-132
23275449-0	2013	Protein domain histochemistry (PDH): binding of the carbohydrate recognition domain (CRD) of recombinant human glycoreceptor CLEC10A (CD301) to formalin-fixed, paraffin-embedded breast cancer tissues.	Formaldehyde	144-152	C-type lectin domain containing 10A	Homo sapiens	134-139
23275449-3	2013	Here, we describe the use of recombinant CLEC10A (CD301), a human glycoreceptor of the C-type lectin family, for the detection of ligands in sections from formalin-fixed, paraffin-embedded normal and cancerous mammary tissues.	Formaldehyde	155-163	C-type lectin domain containing 10A	Homo sapiens	41-48
23275449-3	2013	Here, we describe the use of recombinant CLEC10A (CD301), a human glycoreceptor of the C-type lectin family, for the detection of ligands in sections from formalin-fixed, paraffin-embedded normal and cancerous mammary tissues.	Formaldehyde	155-163	C-type lectin domain containing 10A	Homo sapiens	50-55
23060122-10	2013	These results confirm the high frequency of SMARCB1 deletions in epithelioid sarcoma and show that multiplex ligation-dependent probe amplification is a reliable method for detection of deletions in these cases, which can be performed on formalin-fixed, paraffin-embedded tissue.	Formaldehyde	238-246	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	Homo sapiens	44-51
22207601-9	2013	The results of the formalin test show that the surfactant-coated PEP administered intravenously 150 min prior to the formalin injection could greatly reduce the pain response in the first phase.	Formaldehyde	19-27	progestagen associated endometrial protein	Homo sapiens	65-68
22207601-9	2013	The results of the formalin test show that the surfactant-coated PEP administered intravenously 150 min prior to the formalin injection could greatly reduce the pain response in the first phase.	Formaldehyde	117-125	progestagen associated endometrial protein	Homo sapiens	65-68
23355207-3	2013	This study is the first to describe the successful use of a CD103 antibody to identify HCL and HCL-variant in paraffin sections of formalin- or Bouin solution- fixed specimens (n = 68) using an immunoperoxidase technique.	Formaldehyde	131-139	integrin subunit alpha E	Homo sapiens	60-65
23421753-8	2013	Pain behavioural analysis of the hph-1 mice showed reduced pain-like responses following intraplantar injection of CFA, formalin and capsaicin; whereas decreased basal level of GTP-CH1 activity had no influence in naive hph-1 mice on acute mechanical and heat pain thresholds.	Formaldehyde	120-128	hyperphenylalaninemia 1	Mus musculus	33-38
23391338-3	2013	METHODS: HER2 levels were centrally analyzed by immunohistochemistry (IHC), silver in situ hybridization (SISH) and qRT-PCR in 217 pretherapeutic formalin-fixed, paraffin-embedded (FFPE) core biopsies.	Formaldehyde	146-154	erb-b2 receptor tyrosine kinase 2	Homo sapiens	9-13
23219842-0	2013	Evidence for the participation of peripheral 5-HT2A, 5-HT2B, and 5-HT2C receptors in formalin-induced secondary mechanical allodynia and hyperalgesia.	Formaldehyde	85-93	5-hydroxytryptamine receptor 2A	Rattus norvegicus	45-51
23219842-0	2013	Evidence for the participation of peripheral 5-HT2A, 5-HT2B, and 5-HT2C receptors in formalin-induced secondary mechanical allodynia and hyperalgesia.	Formaldehyde	85-93	5-hydroxytryptamine receptor 2B	Rattus norvegicus	53-59
23219842-1	2013	The role of 5-HT2A/2B/2C receptors in formalin-induced secondary allodynia and hyperalgesia in rats was assessed.	Formaldehyde	38-46	5-hydroxytryptamine receptor 2A	Rattus norvegicus	12-18
23219842-8	2013	These results suggest that 5-HT released from mast cells after formalin injection sensitizes primary afferent neurons via 5-HT2A/2B/2C receptors leading to the development and maintenance of secondary allodynia and hyperalgesia.	Formaldehyde	63-71	5-hydroxytryptamine receptor 2A	Rattus norvegicus	122-128
22790641-5	2013	Formalin-fixed liver samples were embedded in paraffin, stained for immunohistochemistry with proliferating cell nuclear antigen (PCNA) antibody, and the labeling index was calculated.	Formaldehyde	0-8	proliferating cell nuclear antigen	Rattus norvegicus	94-128
22790641-5	2013	Formalin-fixed liver samples were embedded in paraffin, stained for immunohistochemistry with proliferating cell nuclear antigen (PCNA) antibody, and the labeling index was calculated.	Formaldehyde	0-8	proliferating cell nuclear antigen	Rattus norvegicus	130-134
23400679-0	2013	Comparison of COBAS 4800 KRAS, TaqMan PCR and high resolution melting PCR assays for the detection of KRAS somatic mutations in formalin-fixed paraffin embedded colorectal carcinomas.	Formaldehyde	128-136	KRAS proto-oncogene, GTPase	Homo sapiens	102-106
23414519-2	2013	METHODOLOGY: Immunohistochemical expression of COX2 and iNOS was assessed in formalin fixed paraffin wax processed tissues obtained from 155 patients with bladder cancers (87 SCC and 68 TCC) and 39 patients with benign bladder cystitis.	Formaldehyde	77-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-51
23414519-2	2013	METHODOLOGY: Immunohistochemical expression of COX2 and iNOS was assessed in formalin fixed paraffin wax processed tissues obtained from 155 patients with bladder cancers (87 SCC and 68 TCC) and 39 patients with benign bladder cystitis.	Formaldehyde	77-85	nitric oxide synthase 2	Homo sapiens	56-60
23249834-3	2013	We studied germline and somatic mutations of the CYLD gene by direct sequencing in patients with BSS (n = 49) and MFT (n = 18) using peripheral blood and 90 samples of frozen or formalin-fixed paraffin-embedded tumor tissue selected from 379 available histology specimens.	Formaldehyde	178-186	CYLD lysine 63 deubiquitinase	Homo sapiens	49-53
22767408-8	2013	CONCLUSIONS: Formaldehyde-exposed workers experienced decreased counts of NK cells, regulatory T cells, and CD8(+) effector memory T cells; however, due to the small sample size; these findings need to be confirmed in larger studies.	Formaldehyde	13-25	CD8a molecule	Homo sapiens	108-111
23075422-3	2013	We investigated the number of tumor-infiltrating FOXP3-positive Tregs in formalin-fixed TNBC specimens obtained from patients who received palliative treatment between 1999 and 2007.	Formaldehyde	73-81	forkhead box P3	Homo sapiens	49-54
23268837-14	2013	Mir-34c changes at follow-up could be used as a quantitative biomarker that parallels histologic response in formalin-fixed bronchial biopsies in future lung cancer chemoprevention studies.	Formaldehyde	109-117	microRNA 34c	Mus musculus	0-7
22535378-8	2013	In formalin-fixed paraffin-embedded surgical tissue samples, a combination of miR-375, miR-424 and miR-92a yielded an accuracy of 94% (AUC=0.968) in discriminating carcinomas from adenomas.	Formaldehyde	3-11	microRNA 375	Homo sapiens	78-85
23183892-2	2013	Formaldehyde ferredoxin oxidoreductase is a tungsten-dependent enzyme that catalyzes the oxidative degradation of formaldehyde to formic acid.	Formaldehyde	114-126	thioredoxin reductase 1	Homo sapiens	24-38
23569128-2	2013	METHODS: To evaluate the prognostic significance of downregulated PCDH10 protein levels, immunohistochemistry was used to assess the level of PCDH10 protein in surgically-resected formalin-fixed, paraffin wax-embedded transitional cell carcinoma specimens.	Formaldehyde	180-188	protocadherin 10	Homo sapiens	142-148
23483646-1	2013	BACKGROUND: The aims of this study were to evaluate the abilities of direct sequencing (DS), peptide nucleic acid (PNA) clamping, and pyrosequencing methods to detect epidermal growth factor receptor (EGFR) mutations in formalin-fixed paraffin-embedded (FFPE) non-small cell lung carcinoma (NSCLC) samples and to correlate EGFR mutational status as determined by each method with the clinical response to EGFR tyrosine kinase inhibitors (TKIs).	Formaldehyde	220-228	epidermal growth factor receptor	Homo sapiens	167-199
23483646-1	2013	BACKGROUND: The aims of this study were to evaluate the abilities of direct sequencing (DS), peptide nucleic acid (PNA) clamping, and pyrosequencing methods to detect epidermal growth factor receptor (EGFR) mutations in formalin-fixed paraffin-embedded (FFPE) non-small cell lung carcinoma (NSCLC) samples and to correlate EGFR mutational status as determined by each method with the clinical response to EGFR tyrosine kinase inhibitors (TKIs).	Formaldehyde	220-228	epidermal growth factor receptor	Homo sapiens	201-205
23131707-5	2013	PAR-2 expression was evaluated by immunohistochemical method in formalin-fixed and paraffin-embedded tissues of surgical lung biopsies from patients with IPF.	Formaldehyde	64-72	F2R like trypsin receptor 1	Homo sapiens	0-5
23219522-2	2013	TRPA1 is activated by toxic or irritating volatile agents like allyl isothiocyanate (AITC), tear gas, formalin, or cigarette smoke.	Formaldehyde	102-110	transient receptor potential cation channel subfamily A member 1	Homo sapiens	0-5
23219522-8	2013	Furthermore, AITC or formalin stimulated ERK1/2 in TRPA1-expressing HEK293 cells and in SCLC cells via a Src- and calcium-dependent mechanism.	Formaldehyde	21-29	mitogen-activated protein kinase 3	Homo sapiens	41-47
23219522-8	2013	Furthermore, AITC or formalin stimulated ERK1/2 in TRPA1-expressing HEK293 cells and in SCLC cells via a Src- and calcium-dependent mechanism.	Formaldehyde	21-29	transient receptor potential cation channel subfamily A member 1	Homo sapiens	51-56
23219522-8	2013	Furthermore, AITC or formalin stimulated ERK1/2 in TRPA1-expressing HEK293 cells and in SCLC cells via a Src- and calcium-dependent mechanism.	Formaldehyde	21-29	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	105-108
23394524-8	2013	We found that formalin induced a significant microglia and glia activation normalized by PEA, together with increased expression of glial interleukin 10.	Formaldehyde	14-22	interleukin 10	Mus musculus	138-152
23262439-4	2013	The expression of JARID1B was evaluated by immunohistochemistry in formalin-fixed paraffin-embedded samples of 30 nevi, 27 primary melanomas, four lymph node metastases, and one local recurrence of melanoma.	Formaldehyde	67-75	lysine demethylase 5B	Homo sapiens	18-25
23195894-4	2013	In this study, new intracellular functions of Escherichia coli GAPDH were investigated following a proteomic approach aimed at identifying interacting partners using in vivo formaldehyde cross-linking followed by mass spectrometry.	Formaldehyde	174-186	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	63-68
24252159-4	2013	RESULTS: To detect BRAF V600E mutation in formalin-fixed, paraffin-embedded (FFPE) tissue, we developed a method using Amplification Refractory Mutation System (ARMS)-PCR.	Formaldehyde	42-50	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	19-23
23205744-3	2013	MATERIAL AND METHODS: TIMP-1 expression was evaluated by immunohistochemistry (IHC) on formalin fixed paraffin embedded primary tumor tissue in two independent cohorts comprised of 236 and 192 patients, respectively.	Formaldehyde	87-95	TIMP metallopeptidase inhibitor 1	Homo sapiens	22-28
23484153-5	2013	We assessed ALK fusion status for 95 formalin-fixed paraffin-embedded tumor tissue specimens from 87 patients with NSCLC by FISH and real-time RT-PCR, for 57 specimens from 56 patients by targeted resequencing, and for 14 specimens from 14 patients by IHC.	Formaldehyde	37-45	ALK receptor tyrosine kinase	Homo sapiens	12-15
24501865-7	2013	Immunohistochemical evaluation of the S100A1 protein expression was carried out on representative archival formalin -fixed -paraffin-embedded tissue materials.	Formaldehyde	107-115	S100 calcium binding protein A1	Homo sapiens	38-44
22595948-11	2013	These results demonstrate that mouse monoclonal PAX8 [BC12] stains nuclei exclusively and performs well in formalin-fixed paraffin-embedded tissues.	Formaldehyde	107-115	paired box 8	Homo sapiens	48-52
24240587-4	2013	MATERIALS AND METHODS: We conducted a systematic assessment of EphrinB1 expression in a set of 75 formalin-fixed paraffin-embedded breast cancers, using immunohistochemical staining (IHC) with a specific antibody, and we examined the relationship between EphrinB1 expression, histopathological parameters, and the expression of estrogen (ER), progesterone (PR), and HER-2 receptors.	Formaldehyde	98-106	ephrin B1	Homo sapiens	63-71
24070170-3	2013	METHODS: We evaluated the association between semi-quantitative, immunohistochemical staining of ER in formalin-fixed paraffin-embedded breast carcinomas and breast cancer-specific mortality risk in an observational cohort of invasive breast cancer in 681 white women and 523 black women ages 35-64 years at first diagnosis of invasive breast cancer, who were followed for a median of 10 years.	Formaldehyde	103-111	estrogen receptor 1	Homo sapiens	97-99
23691506-8	2013	EGFR mutation analysis using formalin-fixed paraffin-embedded lung cancer tissues demonstrated a mutant peak with Method A, whereas the mutant peak was undetectable with Methods B or C. Method A yielded the best DNA quantity and quality with outstanding efficiency, particularly when paucicellular specimens were used.	Formaldehyde	29-37	epidermal growth factor receptor	Homo sapiens	0-4
24596534-2	2013	MATERIAL AND METHODS: In the present work, the expression of HER-3 in a group of 35 HER-2 positive patients with BC was studied by performing immunohistochemistry (IHC) in formalin-fixed paraffin embedded tissues.	Formaldehyde	172-180	erb-b2 receptor tyrosine kinase 3	Homo sapiens	61-66
23818916-3	2013	The results showed that significant upregulated expressions of CD45 and MHC class I antigen in spinal microglia as well as morphological changes with increased staining with CD11b and Iba-1 were seen in CCI and formalin models and not found in CFA-induced inflammatory pain model.	Formaldehyde	211-219	protein tyrosine phosphatase receptor type C	Homo sapiens	63-67
23818916-3	2013	The results showed that significant upregulated expressions of CD45 and MHC class I antigen in spinal microglia as well as morphological changes with increased staining with CD11b and Iba-1 were seen in CCI and formalin models and not found in CFA-induced inflammatory pain model.	Formaldehyde	211-219	MHC class I antigen	Homo sapiens	72-91
23818916-3	2013	The results showed that significant upregulated expressions of CD45 and MHC class I antigen in spinal microglia as well as morphological changes with increased staining with CD11b and Iba-1 were seen in CCI and formalin models and not found in CFA-induced inflammatory pain model.	Formaldehyde	211-219	integrin subunit alpha M	Homo sapiens	174-179
23818916-3	2013	The results showed that significant upregulated expressions of CD45 and MHC class I antigen in spinal microglia as well as morphological changes with increased staining with CD11b and Iba-1 were seen in CCI and formalin models and not found in CFA-induced inflammatory pain model.	Formaldehyde	211-219	allograft inflammatory factor 1	Homo sapiens	184-189
22796768-1	2013	Formaldehyde dehydrogenase (FDH, molecular size of 8.6 nm x 8.6 nm x 19.0 nm) was immobilized on seven types of mesoporous silica (MPS), whose pores were from 2.4 to 31.2 nm sized, and their catalytic activities were evaluated by oxidation of formaldehyde.	Formaldehyde	243-255	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	0-26
22796768-6	2013	Immobilized FDH on MPS-4-Ph was active for low formaldehyde concentration form 6.0 muM and more sensitive than conventional formaldehyde detectors.	Formaldehyde	47-59	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	12-15
22796768-6	2013	Immobilized FDH on MPS-4-Ph was active for low formaldehyde concentration form 6.0 muM and more sensitive than conventional formaldehyde detectors.	Formaldehyde	124-136	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	12-15
23841222-0	2013	Detection of the epidermal growth factor receptor, amphiregulin and epiregulin in formalin-fixed paraffin-embedded human placenta tissue by matrix-assisted laser desorption/ionization mass spectrometry imaging.	Formaldehyde	82-90	epidermal growth factor receptor	Homo sapiens	17-49
23841222-0	2013	Detection of the epidermal growth factor receptor, amphiregulin and epiregulin in formalin-fixed paraffin-embedded human placenta tissue by matrix-assisted laser desorption/ionization mass spectrometry imaging.	Formaldehyde	82-90	epiregulin	Homo sapiens	68-78
23841222-4	2013	Here, we report the development of a matrix-assisted laser desorption/ionisation mass spectrometry imaging methodology for the study of EGFR, epiregulin and amphiregulin distribution in formalin fixed paraffin embedded human placental tissue and a comparison to expression patterns obtained by immunohiostochemistry.	Formaldehyde	186-194	epidermal growth factor receptor	Homo sapiens	136-140
23841222-4	2013	Here, we report the development of a matrix-assisted laser desorption/ionisation mass spectrometry imaging methodology for the study of EGFR, epiregulin and amphiregulin distribution in formalin fixed paraffin embedded human placental tissue and a comparison to expression patterns obtained by immunohiostochemistry.	Formaldehyde	186-194	amphiregulin	Homo sapiens	157-169
23514787-0	2013	Volume transmission of substance P in striatum induced by intraplantar formalin injection attenuates nociceptive responses via activation of the neurokinin 1 receptor.	Formaldehyde	71-79	tachykinin receptor 1	Rattus norvegicus	145-166
23995116-0	2013	MYD88 (L265P) Mutation in Malignant Lymphoma Using Formalin-Fixed Paraffin-Embedded Section.	Formaldehyde	51-59	MYD88 innate immune signal transduction adaptor	Homo sapiens	0-5
23306911-2	2013	Deficiency of aldehyde dehydrogenase-2 increases the level of formaldehyde when drinking, and is considered an important factor for causing middle or lower pharyngeal cancer and esophageal cancer.	Formaldehyde	62-74	aldehyde dehydrogenase 2 family member	Homo sapiens	14-38
22939954-3	2013	The expression of galectin 1 was determined in 73 formalin-fixed, paraffin-embedded cervical cancer tissues using an immunohistochemical method and compared with clinicopathologic risk factors for recurrence after surgery.	Formaldehyde	50-58	galectin 1	Homo sapiens	18-28
22644781-2	2013	We investigated the phosphorylation status of STAT3 and the protein expression of the suppressor of cytokine signaling 3 (SOCS3) by immunohistochemistry in 145 formalin-fixed, paraffin-embedded samples of soft tissue leiomyosarcoma (LMS), including 129 primary tumors.	Formaldehyde	160-168	suppressor of cytokine signaling 3	Homo sapiens	122-127
23514787-2	2013	A slow-onset but significant increase of SP and neurokinin 1 receptor (NK1R) internalization in the contralateral striatum were observed following the second phase of formalin-induced nociceptive behaviors.	Formaldehyde	167-175	tachykinin receptor 1	Rattus norvegicus	48-69
23514787-2	2013	A slow-onset but significant increase of SP and neurokinin 1 receptor (NK1R) internalization in the contralateral striatum were observed following the second phase of formalin-induced nociceptive behaviors.	Formaldehyde	167-175	tachykinin receptor 1	Rattus norvegicus	71-75
23514787-3	2013	Moreover, 60 min after formalin injection, preprotachykinin-A, the SP mRNA, and the immediate early gene cFOS were upregulated in the contralateral striatum.	Formaldehyde	23-31	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	105-109
23036330-8	2013	Here we present a study which investigates whether ddPCR can be used to assess HER2 transcript levels in formalin-fixed paraffin embedded (FFPE) human breast tumors and whether these ddPCR measurements agree with prior assessments of these same samples by pathologists using immunohistochemistry (IHC) and in some cases fluorescence in situ hybridization (FISH).	Formaldehyde	105-113	erb-b2 receptor tyrosine kinase 2	Homo sapiens	79-83
24222856-0	2013	Identification of DLEC1 D215N Somatic Mutation in Formalin Fixed Paraffin Embedded Melanoma and Melanocytic Nevi Specimens.	Formaldehyde	50-58	DLEC1 cilia and flagella associated protein	Homo sapiens	18-23
23555954-9	2013	We also found, in clinical formalin fixed paraffin embedded (FFPE) lung cancer samples, that low expression of miR-146a was correlated with advanced clinical TNM stages and distant metastasis in NSCLC (P&lt;0.05).	Formaldehyde	27-35	microRNA 146a	Homo sapiens	111-119
24640083-0	2013	[Features of dyslipidemia development and insulin resistance in female workers engaged in methanol and formaldehyde production].	Formaldehyde	103-115	insulin	Homo sapiens	42-49
23217538-2	2013	STUDY DESIGN: Immunoexpression of p63 protein was studied and quantified in 9 formalin-fixed paraffin-embedded mucous retention cysts, 4 papillary cystadenomas, and 19 low-grade and 9 high-grade mucoepidermoid carcinomas.	Formaldehyde	78-86	tumor protein p63	Homo sapiens	34-37
23555633-4	2013	We identified 5 different BRAF mutations in a single assay analyzing 75 different formalin-fixed paraffin-embedded (FFPE) samples of cutaneous melanoma metastases from 29 patients.	Formaldehyde	82-90	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	26-30
23555638-5	2013	The acute visceral pain behaviors, the colon histological changes and the temporal and spatial changes of NK1R-ir structures and Fos expression in the neurons of the DCN were observed in rats following lower colon instillation with 5% formalin.	Formaldehyde	235-243	tachykinin receptor 1	Rattus norvegicus	106-110
23555638-9	2013	Meanwhile, formalin instillation induced a biphasic visceral pain response as well as a strong expression of Fos protein in the nuclei of neurons in the DCN.	Formaldehyde	11-19	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	109-112
23460885-8	2013	Here we report a newly developed EpCAM RNA aptamer, also known as a chemical antibody, which is not only specific but also more sensitive than current antibodies for the detection of EpCAM in formalin-fixed paraffin-embedded primary breast cancers.	Formaldehyde	192-200	epithelial cell adhesion molecule	Homo sapiens	33-38
23516604-3	2013	The main objective of this investigation was to clarify the relationships between HuR expression and clinical significance and cancer cell proliferation, angiogenesis, lymphangiogenesis, and expressions of cyclooxygenase (COX)-2 and vascular endothelial growth factor (VEGF)-A, -C, and -D. METHODS: All expressions were examined by immunohistochemical techniques in 122 formalin-fixed specimens of bladder cancer patients.	Formaldehyde	370-378	ELAV like RNA binding protein 1	Homo sapiens	82-85
23460885-8	2013	Here we report a newly developed EpCAM RNA aptamer, also known as a chemical antibody, which is not only specific but also more sensitive than current antibodies for the detection of EpCAM in formalin-fixed paraffin-embedded primary breast cancers.	Formaldehyde	192-200	epithelial cell adhesion molecule	Homo sapiens	183-188
23661346-2	2013	MATERIAL AND METHOD: Immunohistochemical staining of cyclin D1 on formalin-fixed, paraffin-embedded tissue sections of odontogenic keratocysts (n=23), dentigerous cysts (n=20), radicular cysts (n=20) and glandular odontogenic cysts (n=5) was performed by standard EnVision method.	Formaldehyde	66-74	cyclin D1	Homo sapiens	53-62
23825951-7	2013	Further biochemical analysis by formaldehyde and UV cross-linking demonstrated that NS1-BP did not interact directly with viral M1 mRNA but its interacting partners, hnRNPs A1, K, L, and M, directly bound M1 mRNA.	Formaldehyde	32-44	influenza virus NS1A binding protein	Homo sapiens	84-90
23584600-0	2013	A multisite blinded study for the detection of BRAF mutations in formalin-fixed, paraffin-embedded malignant melanoma.	Formaldehyde	65-73	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	47-51
23657727-5	2013	Scavenging this elevated formaldehyde by formaldehyde-degrading enzyme (FDH), or enhancing DNA demethylation by a DNA demethylating agent, both led to spatial memory deficits by blocking DNA re-methylation in rats.	Formaldehyde	25-37	alcohol dehydrogenase 5 (class III), chi polypeptide	Rattus norvegicus	41-70
23657727-5	2013	Scavenging this elevated formaldehyde by formaldehyde-degrading enzyme (FDH), or enhancing DNA demethylation by a DNA demethylating agent, both led to spatial memory deficits by blocking DNA re-methylation in rats.	Formaldehyde	25-37	alcohol dehydrogenase 5 (class III), chi polypeptide	Rattus norvegicus	72-75
23030524-0	2012	Assessing HER2 amplification by IHC, FISH, and real-time polymerase chain reaction analysis (real-time PCR) following LCM in formalin-fixed paraffin embedded tissue from 40 women with ovarian cancer.	Formaldehyde	125-133	erb-b2 receptor tyrosine kinase 2	Homo sapiens	10-14
23648296-9	2013	CONCLUSIONS: The success rate of ADx-EGFR real-time PCR for formalin-fixed and paraffin-embedded tissues samples is significantly higher than that of Sanger sequencing (P &lt; 0.01).	Formaldehyde	60-68	epidermal growth factor receptor	Homo sapiens	37-41
22999972-9	2012	We then used the formalin test to show that chemical nociception is reduced in reeler and dab1 mutants and that there is a corresponding decrease in formalin-induced Fos expression.	Formaldehyde	149-157	FBJ osteosarcoma oncogene	Mus musculus	166-169
23216670-7	2012	In paraffin-embedded, formalin-fixed tissues from core needle biopsy tissues from 112 patients, positive phospho-p90RSK expression was associated with greater tumor shrinkage and smaller post-chemotherapy tumor size.	Formaldehyde	22-30	ribosomal protein S6 kinase A1	Homo sapiens	113-119
23186160-3	2012	After inkjet-printed or pen-written on plastic sheets, DEA in the silver ink decomposes at temperatures higher than 50  C and generates formaldehyde, which reacts spontaneously with silver ammonia ions to form silver thin films.	Formaldehyde	136-148	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	24-27
23198868-3	2012	RESULTS: In this study, fluorescence in situ hybridization (FISH) using a break-apart probe for the ALK gene was performed on formalin fixed paraffin-embedded tissue to determine the incidence of ALK rearrangements and hybridization patterns in a large unselected cohort of 1387 patients with a referred diagnosis of non-small cell lung cancer (1011 of these patients had a histologic diagnosis of adenocarcinoma).	Formaldehyde	126-134	ALK receptor tyrosine kinase	Homo sapiens	100-103
24049650-3	2012	Immunohistochemical techniques were used to examine the accumulation of the proinflammatory cytokine IL-17 in forty (n = 40) formalin-fixed, paraffin-embedded oesophageal archived specimens across a range of endoscopic diagnostic categories, and a highly significant difference was found, where P &lt;= 0.001, in IL-17 expression (Kruskall Wallis and Mann-Whitney U) between all the cell types examined.	Formaldehyde	125-133	interleukin 17A	Homo sapiens	101-106
22814938-3	2012	Therefore, we investigated the role of the NO in modulation of the expression of DREAM in formalin-induced rat inflammatory pain models.	Formaldehyde	90-98	potassium voltage-gated channel interacting protein 3	Rattus norvegicus	81-86
22814938-11	2012	The expression of DREAM was significantly increased in the rat spinal cord after formalin-induced pain.	Formaldehyde	81-89	potassium voltage-gated channel interacting protein 3	Rattus norvegicus	18-23
23482890-7	2012	Both immune-histo-chemical (IHC) study and polymerase chain reaction (PCR) for detection of late membrane antigen (LMP) were performed on formalin fixed paraffin embedded tissue.	Formaldehyde	138-146	PDZ and LIM domain 7	Homo sapiens	115-118
22899296-2	2012	Here, we compare the expression of CD200 with other markers of primary mediastinal large B cell lymphoma, including MAL and CD23, in formalin-fixed, paraffin-embedded histologic sections from a series of 35 cases of primary mediastinal large B cell lymphoma and 30 cases of diffuse large B cell lymphoma.	Formaldehyde	133-141	CD200 molecule	Homo sapiens	35-40
23154548-5	2012	fluorescence in situ hybridization was performed for FGFR1 on formalin-fixed paraffin-embedded tumor tissue.	Formaldehyde	62-70	fibroblast growth factor receptor 1	Homo sapiens	53-58
22766794-12	2012	Detection of CTNNB1 mutations in formalin-fixed paraffin-embedded tissues among spindle cell lesions is proposed as a specific diagnostic tool for the diagnosis of desmoid tumors.	Formaldehyde	33-41	catenin beta 1	Homo sapiens	13-19
23017599-8	2012	The transporter responsible for the formaldehyde-induced GSH export from OLN-93 cells is most likely the multidrug resistance protein 1 (Mrp1), since this transporter is expressed in these cells and since the inhibitor MK571 completely prevented the formaldehyde-induced GSH export.	Formaldehyde	36-48	ATP binding cassette subfamily C member 1	Rattus norvegicus	105-135
23017599-8	2012	The transporter responsible for the formaldehyde-induced GSH export from OLN-93 cells is most likely the multidrug resistance protein 1 (Mrp1), since this transporter is expressed in these cells and since the inhibitor MK571 completely prevented the formaldehyde-induced GSH export.	Formaldehyde	36-48	ATP binding cassette subfamily C member 1	Rattus norvegicus	137-141
23017599-8	2012	The transporter responsible for the formaldehyde-induced GSH export from OLN-93 cells is most likely the multidrug resistance protein 1 (Mrp1), since this transporter is expressed in these cells and since the inhibitor MK571 completely prevented the formaldehyde-induced GSH export.	Formaldehyde	250-262	ATP binding cassette subfamily C member 1	Rattus norvegicus	105-135
23017599-8	2012	The transporter responsible for the formaldehyde-induced GSH export from OLN-93 cells is most likely the multidrug resistance protein 1 (Mrp1), since this transporter is expressed in these cells and since the inhibitor MK571 completely prevented the formaldehyde-induced GSH export.	Formaldehyde	250-262	ATP binding cassette subfamily C member 1	Rattus norvegicus	137-141
22922083-5	2012	In the present study, using the formalin test, attempts were made to evaluate the effects of acute immobilization restraint stress and swimming stress on pain behavioral responses following OX1R antagonist administration in rats.	Formaldehyde	32-40	hypocretin receptor 1	Rattus norvegicus	190-194
23252871-6	2012	Our reverse transcription-polymerase chain reaction using the formalin-fixed, paraffin-embedded tumor tissues detected EWSR1-CREB1 fusion transcript, but could not demonstrate EWSR1-ATF1 fusion or EWSR1/TAF15/TFG-NR4A3 fusion.	Formaldehyde	62-70	EWS RNA binding protein 1	Homo sapiens	119-124
23252871-6	2012	Our reverse transcription-polymerase chain reaction using the formalin-fixed, paraffin-embedded tumor tissues detected EWSR1-CREB1 fusion transcript, but could not demonstrate EWSR1-ATF1 fusion or EWSR1/TAF15/TFG-NR4A3 fusion.	Formaldehyde	62-70	cAMP responsive element binding protein 1	Homo sapiens	125-130
23593888-5	2012	The formaldehyde derivative was separated on an Agilent C18 column (250 mm x 4.6 mm, 5 microm) at 30 degrees C with acetonitrile-water (60:40, v/v) as mobile phase at a flow rate of 1.0 mL/min, and detected at the wavelength of 355 nm.	Formaldehyde	4-16	Bardet-Biedl syndrome 9	Homo sapiens	56-59
23137022-4	2012	The analysis of syndecan-1 expression in liver biopsies was performed by immunohistochemistry on formalin-fixed, paraffin-embedded samples.	Formaldehyde	97-105	syndecan 1	Homo sapiens	16-26
23151048-4	2012	METHODS: Trop-2 protein expression was quantified using tissue microarrays consisting of formalin-fixed paraffin-embedded specimens from 118 patients who underwent surgical staging from 2001-9 by laparotomy for EEC.	Formaldehyde	89-97	tumor associated calcium signal transducer 2	Homo sapiens	9-15
22697487-9	2012	Formalin fixation without antigen retrieval led to inadequate visualization of alpha-SMA, vimentin, type I- and type III collagen, and laminin.	Formaldehyde	0-8	vimentin	Homo sapiens	90-98
23174497-10	2012	The Food and Drug Administration has approved the cobas BRAF V600 Mutation Test developed by Roche to analyze BRAF mutation status in formalin-fixed paraffin-embedded tumor samples.	Formaldehyde	134-142	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	56-60
23174497-10	2012	The Food and Drug Administration has approved the cobas BRAF V600 Mutation Test developed by Roche to analyze BRAF mutation status in formalin-fixed paraffin-embedded tumor samples.	Formaldehyde	134-142	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	110-114
23174497-13	2012	Some cross-reactivity with other variants of mutant BRAF was seen with the cobas V600 platform; however, this clinical test offers highly sensitive reproducible BRAF V600E mutation analysis in formalin-fixed paraffin-embedded tumor samples.	Formaldehyde	193-201	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	52-56
23174497-13	2012	Some cross-reactivity with other variants of mutant BRAF was seen with the cobas V600 platform; however, this clinical test offers highly sensitive reproducible BRAF V600E mutation analysis in formalin-fixed paraffin-embedded tumor samples.	Formaldehyde	193-201	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	161-165
23011482-0	2012	Comment on "a comparison of three methods for detecting KRAS mutations in formalin-fixed colorectal cancer specimens".	Formaldehyde	74-82	KRAS proto-oncogene, GTPase	Homo sapiens	56-60
23009111-3	2012	The real-time quantitative reverse transcription-polymerase chain reaction was carried out to detect TLR9 expression in 41 formalin-fixed paraffin-embedded samples.	Formaldehyde	123-131	toll like receptor 9	Homo sapiens	101-105
23226727-4	2012	We observed KRAS mutations in formalin-fixed, paraffin-embedded tissues by PCR direct sequencing and in blood samples by PNA clamp PCR.	Formaldehyde	30-38	KRAS proto-oncogene, GTPase	Homo sapiens	12-16
22332713-0	2012	Multisite analytic performance studies of a real-time polymerase chain reaction assay for the detection of BRAF V600E mutations in formalin-fixed, paraffin-embedded tissue specimens of malignant melanoma.	Formaldehyde	131-139	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	107-111
22993408-9	2012	These MAbs are the first reported anti-NS1 MAbs that can be used for WNV-specific IHC using formalin-fixed, paraffin-embedded sections.	Formaldehyde	92-100	influenza virus NS1A binding protein	Homo sapiens	39-42
23226728-3	2012	The expression of NEDD9 was analyzed by the SP method of immunohistochemistry for 60 formalin-fixed and paraffin-embedded (FFPE) lung adenocarcinoma tissues in which 32 cases were metastastic and 28 were without metastases.	Formaldehyde	85-93	neural precursor cell expressed, developmentally down-regulated 9	Homo sapiens	18-23
22923193-5	2012	EGFR mutations of 126 Formalin-Fixed Paraffin-Embedded (FFPE), 47 fresh frozen             tissues and from 47 matched pre-operation serum specimens of NSCLC patients were             screened by the HRM assays.	Formaldehyde	22-30	epidermal growth factor receptor	Homo sapiens	0-4
23653844-4	2012	Due to high incidence, mortality, and recurrence rates of bladder cancer and the necessity of accurate prediction of malignant behavior of the tumors, we evaluated the prognostic value of Oct4 expression in formalin-fixed paraffin-embedded (FFPE) tissues of bladder cancer.	Formaldehyde	207-215	POU class 5 homeobox 1	Homo sapiens	188-192
22975136-3	2012	In inflammation group, formalin injection produced a bilateral increase in c-Fos at vestibular nucleus with ipsilesional side higher activity.	Formaldehyde	23-31	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	75-80
23302486-3	2012	The mutations of PIK3CA exon 9 and 20, PTEN exon 5, 7, 8 in primary cancer cells in formalin-fixed, paraffin-embedded specimens were detected by Pyrosequencing, then a statistical analysis was deduced to find out the relationship between PIK3CA, PTEN status and occurrences of liver metastasis as well as the prognosis.	Formaldehyde	84-92	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	17-37
23302486-3	2012	The mutations of PIK3CA exon 9 and 20, PTEN exon 5, 7, 8 in primary cancer cells in formalin-fixed, paraffin-embedded specimens were detected by Pyrosequencing, then a statistical analysis was deduced to find out the relationship between PIK3CA, PTEN status and occurrences of liver metastasis as well as the prognosis.	Formaldehyde	84-92	phosphatase and tensin homolog	Homo sapiens	39-43
23302486-3	2012	The mutations of PIK3CA exon 9 and 20, PTEN exon 5, 7, 8 in primary cancer cells in formalin-fixed, paraffin-embedded specimens were detected by Pyrosequencing, then a statistical analysis was deduced to find out the relationship between PIK3CA, PTEN status and occurrences of liver metastasis as well as the prognosis.	Formaldehyde	84-92	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	17-23
23302487-0	2012	[Correlation of miR-155 on formalin-fixed paraffin embedded tissues with invasiveness and prognosis of breast cancer].	Formaldehyde	27-35	microRNA 155	Homo sapiens	16-23
22867799-5	2012	A large number of c-Fos-positive neurons were observed in rat injected with a mixture of formalin and vehicle, but not in rat treated with a mixture of formalin and HYP-1.	Formaldehyde	89-97	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	18-23
22906776-0	2012	Intra-paragigantocellularis lateralis injection of orexin-A has an antinociceptive effect on hot plate and formalin tests in rat.	Formaldehyde	107-115	hypocretin neuropeptide precursor	Rattus norvegicus	51-59
22820168-0	2012	Over-expression of endothelin-1 in astrocytes, but not endothelial cells, ameliorates inflammatory pain response after formalin injection.	Formaldehyde	119-127	endothelin 1	Mus musculus	19-31
22820168-4	2012	MAIN METHODS: The current study assesses the effects of ET-1 over-expression specifically targeted to astrocytes (GET-1) or endothelial cells (TET-1) on the expression of pain-like behaviors induced by a model of inflammatory pain, consisting of a formalin injection into the hind paw.	Formaldehyde	248-256	endothelin 1	Mus musculus	56-60
22820168-6	2012	Relative to the NTg controls, GET-1 mice displayed a marked decrease in pain-like behavioral responses during the second phase of formalin-induced pain (i.e., 15-20 min after injection), whereas the responses elicited in TET-1 mice were unaltered.	Formaldehyde	130-138	activating transcription factor 7 interacting protein 2	Mus musculus	30-35
22960202-4	2012	In the control and saline/formalin injected rats, scattered mRFP1 fluorescence in the spinal cord and the PVN was observed at 0 min, though there was little Fos-LI in the same region.	Formaldehyde	26-34	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	157-160
22906776-3	2012	ORXA (0.1-100 nM/0.5 muL) microinjected into the LPGi nucleus, dose-dependently decreased the formalin induced nociceptive behaviors and also produced a dose-dependent antinociceptive effect in the hot-plate test.	Formaldehyde	94-102	hypocretin neuropeptide precursor	Rattus norvegicus	0-4
22906776-4	2012	Pretreatment with a selective orexin receptor 1 (OX1R) antagonist, SB-334867, also inhibited the effect of ORXA on formalin induced nociceptive behaviors while the SB-334867 (100 muM) alone had no effect on formalin test.	Formaldehyde	115-123	hypocretin receptor 1	Rattus norvegicus	49-53
22906776-4	2012	Pretreatment with a selective orexin receptor 1 (OX1R) antagonist, SB-334867, also inhibited the effect of ORXA on formalin induced nociceptive behaviors while the SB-334867 (100 muM) alone had no effect on formalin test.	Formaldehyde	115-123	hypocretin neuropeptide precursor	Rattus norvegicus	107-111
22906776-4	2012	Pretreatment with a selective orexin receptor 1 (OX1R) antagonist, SB-334867, also inhibited the effect of ORXA on formalin induced nociceptive behaviors while the SB-334867 (100 muM) alone had no effect on formalin test.	Formaldehyde	207-215	hypocretin receptor 1	Rattus norvegicus	49-53
22906776-4	2012	Pretreatment with a selective orexin receptor 1 (OX1R) antagonist, SB-334867, also inhibited the effect of ORXA on formalin induced nociceptive behaviors while the SB-334867 (100 muM) alone had no effect on formalin test.	Formaldehyde	207-215	hypocretin neuropeptide precursor	Rattus norvegicus	107-111
22732508-0	2012	Application of pyrosequencing technique for improved detection of K-Ras mutation in formalin-fixed and paraffin-embedded prostate carcinoma tissues in Chinese patients.	Formaldehyde	84-92	KRAS proto-oncogene, GTPase	Homo sapiens	66-71
22732508-1	2012	BACKGROUND: The purpose of this study was to comparatively evaluate the efficacy of pyrosequencing (PS) and Sanger sequencing (SS) methods for detecting K-Ras codon 12 and 13 mutations in formalin-fixed paraffin-embedded (FFPE) prostate cancer (PCa) samples from Chinese patients.	Formaldehyde	188-196	KRAS proto-oncogene, GTPase	Homo sapiens	153-158
21990036-0	2012	Quantitative determination of insulin-like growth factor 1 receptor mRNA in formalin-fixed paraffin-embedded tissues of invasive breast cancer.	Formaldehyde	76-84	insulin like growth factor 1 receptor	Homo sapiens	30-67
23031716-5	2012	The expression of B cell-specific Moloney murine leukemia virus integration site 1 (BMI-1) was examined immunohistochemically on formalin-fixed paraffin-embedded primary tissue specimens.	Formaldehyde	129-137	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	84-89
21990036-2	2012	Previously analysis of its gene expression has been restricted to fresh-frozen (FF) samples, but application of this technique to routinely processed formalin-fixed paraffin-embedded (FFPE) samples could facilitate larger retrospective studies correlating IGF1R expression with prognosis and therapeutic response.	Formaldehyde	150-158	insulin like growth factor 1 receptor	Homo sapiens	256-261
23168703-6	2012	Mutational analysis of TP53 was done in DNA extracted from formalin fixed paraffin embedded tissue of 80 CaP and 24 BPH cases.	Formaldehyde	59-67	tumor protein p53	Homo sapiens	23-27
22918472-5	2012	PC4 protein expression is significantly upregulated in NSCLC carcinoma tissues compared with their adjacent noncancerous counterparts as shown by immunohistochemical staining and western blotting in 104 pairs of formalin-fixed human NSCLC specimens and 6 fresh NSCLC samples.	Formaldehyde	212-220	SUB1 regulator of transcription	Homo sapiens	0-3
22419537-5	2012	WT and KCS237 formalin-killed and live bacteria, as well as their LPS, strongly stimulated production of pro-inflammatory cytokines in human U937 cells; this stimulation was suppressed by TLR4 suppressors.	Formaldehyde	14-22	toll like receptor 4	Homo sapiens	188-192
23031400-0	2012	Activation of Src family kinases in spinal microglia contributes to formalin-induced persistent pain state through p38 pathway.	Formaldehyde	68-76	mitogen-activated protein kinase 14	Homo sapiens	115-118
22325460-4	2012	METHODS: Sox10 expression was examined by immunohistochemistry in 145 cases of formalin-fixed paraffin-embedded tissue, including benign and malignant melanocytic lesions of various histologies and stages (n = 83), fibrohistiocytic and histiocytic lesions (n = 33), and peripheral nerve sheath tumors (n = 19), among others (n = 10).	Formaldehyde	79-87	SRY-box transcription factor 10	Homo sapiens	9-14
23031400-3	2012	In the formalin test, we have reported that microglia undergo at least 2 distinct stages of activation on the basis of signaling events regarding p38 mitogen-activated protein kinases (MAPK).	Formaldehyde	7-15	mitogen-activated protein kinase 14	Homo sapiens	146-149
23031400-7	2012	However, PP2 inhibited formalin injury, induced persistent mechanical hyperalgesia, and reversed microglial phospho-p38 expression as well using immunohistostaining and Western blot at day 3 and 7 after injection.	Formaldehyde	23-31	neuropeptide Y receptor Y6 (pseudogene)	Homo sapiens	9-12
22687715-6	2012	In addition, IL-8 and IL-6 levels were significantly higher in culture supernatants of A549 cells that were incubated with formaldehyde-fixed P. brasiliensis compared to cultures of cells that were infected with live yeasts.	Formaldehyde	123-135	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
22687715-6	2012	In addition, IL-8 and IL-6 levels were significantly higher in culture supernatants of A549 cells that were incubated with formaldehyde-fixed P. brasiliensis compared to cultures of cells that were infected with live yeasts.	Formaldehyde	123-135	interleukin 6	Homo sapiens	22-26
23205078-5	2012	Formalin-fixed and paraffin-embedded samples of ductal invasive breast carcinomas were used to analyze the expression of PAR1 and FGFR1, in the tumor cells as well as in the tumor stroma, and further determine intratumoral microvessel density (iMVD) to quantify intratumoral angiogenesis.	Formaldehyde	0-8	coagulation factor II thrombin receptor	Homo sapiens	121-125
22947189-7	2012	METHODS AND RESULTS: HLA-E expression was assessed by immunohistochemistry on formalin-fixed, paraffin-embedded tissue sections of 79 SCC, 38 ASC, and 75 AC patients.	Formaldehyde	78-86	major histocompatibility complex, class I, E	Homo sapiens	21-26
23311134-7	2012	The expression of cyp2e1 in transgenic tobacco with cyp2e1 decreased obviously treated by ethyl alcohol and reduced slightly by benzene and toluene, while it enhanced by acetone, formaldehyde and oxygen deficit in different levels.	Formaldehyde	179-191	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	18-24
22648564-2	2012	The immunohistochemical expression of Beclin 1 and LC3 were evaluated in 26 formalin-fixed paraffin-embedded cervical normal tissue samples and 50 tumor samples of FIGO stage I-II cervical squamous cell carcinoma, respectively.	Formaldehyde	76-84	beclin 1	Homo sapiens	38-46
22898152-4	2012	In addition, we determined whether formalin injection modifies the expression of NHE1 in lumbar dorsal root ganglia (DRG) and dorsal spinal cord.	Formaldehyde	35-43	solute carrier family 9 member A1	Rattus norvegicus	81-85
22898152-8	2012	Formalin injection reduced NHE1 expression in ipsilateral and contralateral spinal dorsal horns from day 1 to 12.	Formaldehyde	0-8	solute carrier family 9 member A1	Rattus norvegicus	27-31
22898152-9	2012	In addition, formalin diminished NHE1 protein expression in DRG at day 12.	Formaldehyde	13-21	solute carrier family 9 member A1	Rattus norvegicus	33-37
22898152-10	2012	These results suggest that NHE1 plays a role in pain processing at peripheral and spinal levels in formalin-induced long-lasting nociceptive behaviors.	Formaldehyde	99-107	solute carrier family 9 member A1	Rattus norvegicus	27-31
22992310-3	2012	METHODS: We evaluated the expression of miR-34 in formalin-fixed paraffin-embedded (FFPE) human colon cancer tissue specimens compared to normal colonic mucosa.	Formaldehyde	50-58	microRNA 34a	Homo sapiens	40-46
22732262-0	2012	The p21-activated kinase PAK 5 is involved in formalin-induced nociception through regulation of MAP-kinase signaling and formalin-specific receptors.	Formaldehyde	46-54	p21 (RAC1) activated kinase 5	Mus musculus	25-30
21114636-4	2012	METHODS: Immunohistochemical analysis of HSP-27 protein expression was performed on formalin-fixed, paraffin-embedded sections from 99 UM of known chromosome 3 status, as determined by multiplex ligation-dependent probe amplification.	Formaldehyde	84-92	heat shock protein family B (small) member 1	Homo sapiens	41-47
22938585-0	2012	High-resolution melting analysis as a sensitive prescreening diagnostic tool to detect KRAS , BRAF , PIK3CA , and AKT1 mutations in formalin-fixed, paraffin-embedded tissues.	Formaldehyde	132-140	KRAS proto-oncogene, GTPase	Homo sapiens	87-91
22938585-0	2012	High-resolution melting analysis as a sensitive prescreening diagnostic tool to detect KRAS , BRAF , PIK3CA , and AKT1 mutations in formalin-fixed, paraffin-embedded tissues.	Formaldehyde	132-140	AKT serine/threonine kinase 1	Homo sapiens	114-118
22732262-7	2012	However, the nociceptive response in formalin-induced paw inflammation was significantly reduced in knock-out mice associated with inhibition of MAP-kinase activation and a decreased number of formalin-induced c-Fos positive neurons in the spinal cord.	Formaldehyde	37-45	FBJ osteosarcoma oncogene	Mus musculus	210-215
22732262-7	2012	However, the nociceptive response in formalin-induced paw inflammation was significantly reduced in knock-out mice associated with inhibition of MAP-kinase activation and a decreased number of formalin-induced c-Fos positive neurons in the spinal cord.	Formaldehyde	193-201	FBJ osteosarcoma oncogene	Mus musculus	210-215
22732262-9	2012	Our results indicate that PAK 5 is involved in formalin-induced inflammatory nociception through regulation of MAPK-induced c-Fos-activation and formalin-specific TRP-channels.	Formaldehyde	47-55	p21 (RAC1) activated kinase 5	Mus musculus	26-31
22732262-9	2012	Our results indicate that PAK 5 is involved in formalin-induced inflammatory nociception through regulation of MAPK-induced c-Fos-activation and formalin-specific TRP-channels.	Formaldehyde	47-55	FBJ osteosarcoma oncogene	Mus musculus	124-129
22732262-9	2012	Our results indicate that PAK 5 is involved in formalin-induced inflammatory nociception through regulation of MAPK-induced c-Fos-activation and formalin-specific TRP-channels.	Formaldehyde	145-153	p21 (RAC1) activated kinase 5	Mus musculus	26-31
22772381-8	2012	mRNA expression of MARCKSL1 in formalin fixed paraffin-embedded tissue was also prognostic (P = 0.002, HR = 3.6, 95 % CI = 1.5-8.3).	Formaldehyde	31-39	MARCKS like 1	Homo sapiens	19-27
22360629-0	2012	IDH mutation detection in formalin-fixed paraffin-embedded gliomas using multiplex PCR and single-base extension.	Formaldehyde	26-34	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	0-3
22204715-4	2012	We describe an approach for analyzing formalin-fixed, paraffin-embedded breast tumors on tissue microarrays with TOP2A fluorescence in situ hybridization coupled with cytokeratin immunofluorescence to target tumor cells.	Formaldehyde	38-46	DNA topoisomerase II alpha	Homo sapiens	113-118
22673495-3	2012	This may reflect structural differences in PrP(Sc) that have been formalin-fixed prior to their extraction.	Formaldehyde	66-74	major prion protein	Ovis aries	43-46
22954400-8	2012	GSTT1 was up to ten times more active than CYP 2E1 in both cell lines, indicating that potential lung damage is due to formation of pro-carcinogens such as formaldehyde.	Formaldehyde	156-168	glutathione S-transferase theta 1	Homo sapiens	0-5
22954400-8	2012	GSTT1 was up to ten times more active than CYP 2E1 in both cell lines, indicating that potential lung damage is due to formation of pro-carcinogens such as formaldehyde.	Formaldehyde	156-168	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	43-50
22525295-2	2012	The EBf-H9 cells were derived from human embryonic stem cells (H9) via embryonic body (EB) and treated with Sodium fluoride (NaF) and Formaldehyde (FA).	Formaldehyde	134-146	EBF transcription factor 1	Homo sapiens	4-7
22372443-7	2012	CTNNB1 genotyping was done by Sanger sequencing on formalin-fixed paraffin-embedded tissue.	Formaldehyde	51-59	catenin beta 1	Homo sapiens	0-6
22525295-7	2012	The proliferation of EBf-H9 and murine L929 cells was inhibited by sodium fluoride (NaF) and formaldehyde (FA), and the cell cycle was arrested in different phases with the treatments.	Formaldehyde	93-105	early B cell factor 1	Mus musculus	21-24
22814649-7	2012	Pronounced staining was possible for EGFR and IGF-1R with all alternative fixatives but HOPE , and phospho-HER2 staining was only noteworthy with formalin-ultrasound-fixed tissue.	Formaldehyde	146-154	erb-b2 receptor tyrosine kinase 2	Homo sapiens	107-111
22522467-4	2012	We have also shown that intrathecal injection of the targeted cytotoxin, Neuropeptide Y-sap (NPY-sap), is also antinociceptive, reducing nocifensive reflex responses to noxious heat and formalin.	Formaldehyde	186-194	neuropeptide Y	Rattus norvegicus	73-87
22740451-5	2012	Application of quantitative RT-PCR in independent datasets from cryopreserved and formalin-fixed paraffin-embedded samples validated a 3-gene model (TNFRSF8, BATF3, and TMOD1) able to successfully separate ALK(-) ALCL from peripheral T-cell lymphoma not otherwise specified, with overall accuracy near 97%.	Formaldehyde	82-90	TNF receptor superfamily member 8	Homo sapiens	149-156
22740451-5	2012	Application of quantitative RT-PCR in independent datasets from cryopreserved and formalin-fixed paraffin-embedded samples validated a 3-gene model (TNFRSF8, BATF3, and TMOD1) able to successfully separate ALK(-) ALCL from peripheral T-cell lymphoma not otherwise specified, with overall accuracy near 97%.	Formaldehyde	82-90	basic leucine zipper ATF-like transcription factor 3	Homo sapiens	158-163
22740451-5	2012	Application of quantitative RT-PCR in independent datasets from cryopreserved and formalin-fixed paraffin-embedded samples validated a 3-gene model (TNFRSF8, BATF3, and TMOD1) able to successfully separate ALK(-) ALCL from peripheral T-cell lymphoma not otherwise specified, with overall accuracy near 97%.	Formaldehyde	82-90	tropomodulin 1	Homo sapiens	169-174
22740451-5	2012	Application of quantitative RT-PCR in independent datasets from cryopreserved and formalin-fixed paraffin-embedded samples validated a 3-gene model (TNFRSF8, BATF3, and TMOD1) able to successfully separate ALK(-) ALCL from peripheral T-cell lymphoma not otherwise specified, with overall accuracy near 97%.	Formaldehyde	82-90	ALK receptor tyrosine kinase	Homo sapiens	206-209
23105973-3	2012	To assess p-S6 expression we performed immunohistochemistry on formalin-fixed and paraffin-embedded tumours and normal tissues.	Formaldehyde	63-71	taste 2 receptor member 63 pseudogene	Homo sapiens	10-14
22876814-3	2012	METHODS: The KRAS mutational status in codons 12, 13, and 61 from formalin-fixed sections of both primary tumors and related metastases was determined by sequencing analysis.	Formaldehyde	66-74	KRAS proto-oncogene, GTPase	Homo sapiens	13-17
22522467-4	2012	We have also shown that intrathecal injection of the targeted cytotoxin, Neuropeptide Y-sap (NPY-sap), is also antinociceptive, reducing nocifensive reflex responses to noxious heat and formalin.	Formaldehyde	186-194	neuropeptide Y	Rattus norvegicus	93-96
22327864-6	2012	Moreover, AGF at the dose level of 500 mg/kg suppressed the acetic acid-induced abdominal constrictions (p &lt; 0.05) and the formalin-induced spontaneous nociceptive behaviors (p &lt; 0.05) in rats.	Formaldehyde	126-134	ADP-ribosyltransferase 2b	Rattus norvegicus	10-13
22445362-2	2012	Immunohistochemistry using a mouse monoclonal antibody has a high specificity and sensitivity for detecting IDH1 R132H mutant protein in sections from formalin-fixed, paraffin-embedded tissue.	Formaldehyde	151-159	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	108-112
22647537-3	2012	Here, we describe a validated immunohistochemical protocol for the detection of LC3 puncta in human formalin-fixed, paraffin-embedded cancer specimens that can also be applied to mouse tissues.	Formaldehyde	100-108	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	80-83
22765904-4	2012	AMBA reacts with formaldehyde, which is produced enzymatically by BBOX, to give a cyclic adduct.	Formaldehyde	17-29	gamma-butyrobetaine hydroxylase 1	Homo sapiens	66-70
22445362-6	2012	Expression of mutant IDH1 R132H protein was determined by immunohistochemistry on representative formalin-fixed, paraffin-embedded sections using the antihuman mouse monoclonal antibody IDH1 R132H (Dianova, Hamburg, Germany).	Formaldehyde	97-105	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	21-25
22565018-8	2012	Challenge with formalin-inactivated Vibrio anguillarum led to significantly up-regulations of CsHepcidin gene in liver, head kidney and spleen in time-dependent manners.	Formaldehyde	15-23	hepcidin	Cynoglossus semilaevis	94-104
22636769-6	2012	The purified PrgJ and K471E proteins also bound single- and double-stranded DNA substrates without sequence specificity in vitro, and both PrgJ derivatives bound pCF10 in vivo by a mechanism dependent on an intact oriT sequence and cosynthesis of PcfC, PcfF, and PcfG, as shown by a formaldehyde-cross-linking assay.	Formaldehyde	283-295	PrgJ	Enterococcus faecalis	139-143
22302483-8	2012	Immunofluorescence study on formalin-fixed, paraffin-embedded specimens confirmed the cytoplasmic expression of cathepsin D in cancer cells and non-tumor portions.	Formaldehyde	28-36	cathepsin D	Homo sapiens	112-123
22430898-3	2012	Proximity ligation assays (PLAs) were used to determine quantitative expression levels of isoform-specific activation (phosphorylation) of Akt1 and Akt2 in formalin-fixed, paraffin-embedded cell lines and breast cancer tumour tissues in situ.	Formaldehyde	156-164	AKT serine/threonine kinase 1	Homo sapiens	139-143
22430898-3	2012	Proximity ligation assays (PLAs) were used to determine quantitative expression levels of isoform-specific activation (phosphorylation) of Akt1 and Akt2 in formalin-fixed, paraffin-embedded cell lines and breast cancer tumour tissues in situ.	Formaldehyde	156-164	AKT serine/threonine kinase 2	Homo sapiens	148-152
23213753-2	2012	METHOD: Twenty-nine cases of middle ear cholesteatoma tissue, 18 cases of external auditory canal tissue were detected by limulus amebocyte lysate assay (LAL-assay), and expression of MMP-9 protein in formalin-fixed, paraffin-embedded tissues was detected by immunohistochemical method.	Formaldehyde	201-209	matrix metallopeptidase 9	Homo sapiens	184-189
22614944-3	2012	We assessed MGMT promoter methylation in formalin-fixed, primary tumor tissue of metastatic melanoma patients treated with first-line temozolomide and bevacizumab from the trial SAKK 50/07 by methylation-specific polymerase chain reaction.	Formaldehyde	41-49	O-6-methylguanine-DNA methyltransferase	Homo sapiens	12-16
22526496-8	2012	Co-immunoprecipitation of a formaldehyde cross-linked RNA-protein complex indicated that BPG2 protein binds with specificity to chloroplast 16S and 23S ribosomal RNAs.	Formaldehyde	28-40	P-loop containing nucleoside triphosphate hydrolases superfamily protein	Arabidopsis thaliana	89-93
22713664-0	2012	A comparison of three methods for detecting KRAS mutations in formalin-fixed colorectal cancer specimens.	Formaldehyde	62-70	KRAS proto-oncogene, GTPase	Homo sapiens	44-48
22849540-4	2012	adhC could also be induced in response to formaldehyde but not GSNO.	Formaldehyde	42-54	S-(hydroxymethyl)glutathione dehydrogenase	Haemophilus influenzae Rd KW20	0-4
22839358-5	2012	METHODS: c-KIT expression was scored by immunohistochemistry (IHC) as positive or negative in 139 formalin-fixed paraffin-embedded (FFPE) cases of vulvar carcinomas arrayed in a tissue microarray (TMA) using the DAKO A4502 rabbit polyclonal c-KIT antibody (diluted 1:100).	Formaldehyde	98-106	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	9-14
22722496-0	2012	S-phase sensing of DNA-protein crosslinks triggers TopBP1-independent ATR activation and p53-mediated cell death by formaldehyde.	Formaldehyde	116-128	DNA topoisomerase II binding protein 1	Homo sapiens	51-57
22472959-6	2012	MDM2 amplification was analyzed using FISH on formalin-fixed, paraffin-embedded material in 26 cases.	Formaldehyde	46-54	MDM2 proto-oncogene	Homo sapiens	0-4
22417857-1	2012	The study of proto-oncogene Her-2/neu using the fluorescence in situ hybridization (FISH) technique in routinely paraffin-embedded formalin-fixed tissue has become commonplace over the past decade and mandatory among invasive breast cancer expressing a score 2+ by immunohistochemical analysis of c-erbB2 protein.	Formaldehyde	131-139	erb-b2 receptor tyrosine kinase 2	Homo sapiens	34-37
22417858-4	2012	HER2 expression was detected by immunohistochemistry (IHC) performed on formalin-fixed, paraffin-embedded sections of the corresponding tumors.	Formaldehyde	72-80	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-4
22722496-0	2012	S-phase sensing of DNA-protein crosslinks triggers TopBP1-independent ATR activation and p53-mediated cell death by formaldehyde.	Formaldehyde	116-128	tumor protein p53	Homo sapiens	89-92
22634872-6	2012	Furthermore, the variation of SP expression induced by formalin was fluctuated in a similar rhythm to behavioral nociceptive response induced by formalin (n = 48); and the nociceptive behavioral circadian rhythm could be abolished through blockade of the SP-Neurokinin 1 receptor pathway (n = 70).	Formaldehyde	55-63	tachykinin precursor 1	Homo sapiens	30-32
22634872-6	2012	Furthermore, the variation of SP expression induced by formalin was fluctuated in a similar rhythm to behavioral nociceptive response induced by formalin (n = 48); and the nociceptive behavioral circadian rhythm could be abolished through blockade of the SP-Neurokinin 1 receptor pathway (n = 70).	Formaldehyde	145-153	tachykinin precursor 1	Homo sapiens	30-32
22738050-3	2012	PROCEDURES: CB1 and CB2 were immunohistochemically localized in formalin-fixed, paraffin-embedded sections of tissue samples.	Formaldehyde	64-72	cannabinoid receptor 1	Canis lupus familiaris	12-15
22228432-5	2012	We evaluated MGMT methylation status by methylation-specific PCR (MSP) in formalin-fixed and paraffin-embedded tumor specimens from 92 TNBC patients.	Formaldehyde	74-82	O-6-methylguanine-DNA methyltransferase	Homo sapiens	13-17
21823214-7	2012	IDO1 immunohistochemical staining was performed on formalin-fixed tissue blocks.	Formaldehyde	51-59	indoleamine 2,3-dioxygenase 1	Homo sapiens	0-4
22837134-4	2012	METHODS: Immunohistochemical detection of nestin was carried out on tissue microarrays constructed from 114 formalin-fixed and paraffin-embedded NSCLC samples.	Formaldehyde	108-116	nestin	Homo sapiens	42-48
22476011-0	2012	Role of peripheral and spinal 5-HT2B receptors in formalin-induced nociception.	Formaldehyde	50-58	5-hydroxytryptamine receptor 2B	Rattus norvegicus	30-36
22476011-1	2012	In this study we assessed the role of local peripheral and spinal serotonin 2B (5-HT(2B)) receptors in rats submitted to the formalin test.	Formaldehyde	125-133	5-hydroxytryptamine receptor 2B	Rattus norvegicus	80-87
22476011-5	2012	Moreover, intrathecal injection of the selective 5-HT(2B) receptor antagonist RS-127445 (0.1-10 nmol/rat) also prevented 1% formalin-induced nociceptive behavior.	Formaldehyde	124-132	5-hydroxytryptamine receptor 2B	Rattus norvegicus	49-56
22476011-8	2012	Our results suggest that the 5-HT(2B) receptors play a pronociceptive role in peripheral as well as spinal sites in the rat formalin test.	Formaldehyde	124-132	5-hydroxytryptamine receptor 2B	Rattus norvegicus	29-36
20863722-14	2012	CONCLUSION: Tumoral DNA extraction and VHL mutation analysis can be performed from formalin-fixed paraffin-embedded (FFPE) tissue in RCC.	Formaldehyde	83-91	von Hippel-Lindau tumor suppressor	Homo sapiens	39-42
22421194-5	2012	In the retrospective cohort, the concordance of PIK3CA mutation status by BEAMing between formalin-fixed, paraffin-embedded (FFPE) samples and ctDNA from temporally matched plasma was 100% (34 of 34).	Formaldehyde	90-98	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	48-54
22402874-0	2012	Detection of genetic variation in KCNQ1 gene by high-resolution melting analysis in a prospective-based series of postmortem negative sudden death: comparison of results obtained in fresh frozen and formalin-fixed paraffin-embedded tissues.	Formaldehyde	199-207	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	34-39
21777924-2	2012	We report results of a pilot trial designed to determine if treatment-mediated changes in gene expression can be detected in formalin-fixed paraffin-embedded (FFPE) samples after 10-d exposure to anastrozole in estrogen receptor (ER)-positive breast cancer compared with untreated controls.	Formaldehyde	125-133	estrogen receptor 1	Homo sapiens	211-228
21777924-2	2012	We report results of a pilot trial designed to determine if treatment-mediated changes in gene expression can be detected in formalin-fixed paraffin-embedded (FFPE) samples after 10-d exposure to anastrozole in estrogen receptor (ER)-positive breast cancer compared with untreated controls.	Formaldehyde	125-133	estrogen receptor 1	Homo sapiens	230-232
22892044-0	2012	Nm23/nucleoside diphosphate kinase-A as a potent prognostic marker in invasive pancreatic ductal carcinoma identified by proteomic analysis of laser micro-dissected formalin-fixed paraffin-embedded tissue.	Formaldehyde	165-173	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	0-4
22892044-0	2012	Nm23/nucleoside diphosphate kinase-A as a potent prognostic marker in invasive pancreatic ductal carcinoma identified by proteomic analysis of laser micro-dissected formalin-fixed paraffin-embedded tissue.	Formaldehyde	165-173	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	5-36
22220695-8	2012	Formalin increased myeloperoxidase activity, and up-regulated TNF-alpha, IL-1beta and IL-6 in gastrocnemius.	Formaldehyde	0-8	myeloperoxidase	Mus musculus	19-34
22220695-8	2012	Formalin increased myeloperoxidase activity, and up-regulated TNF-alpha, IL-1beta and IL-6 in gastrocnemius.	Formaldehyde	0-8	tumor necrosis factor	Mus musculus	62-71
22555092-3	2012	Quantitative, methylation-specific (HeavyMethyl), real-time polymerase chain reaction assays were used to measure DNA methylation of PITX2 and SHOX2 in bisulfite-converted DNA from formalin-fixed, paraffin-embedded tissues from 474 non-small-cell lung cancer patients.	Formaldehyde	181-189	paired like homeodomain 2	Homo sapiens	133-138
22220695-8	2012	Formalin increased myeloperoxidase activity, and up-regulated TNF-alpha, IL-1beta and IL-6 in gastrocnemius.	Formaldehyde	0-8	interleukin 1 beta	Mus musculus	73-81
22220695-8	2012	Formalin increased myeloperoxidase activity, and up-regulated TNF-alpha, IL-1beta and IL-6 in gastrocnemius.	Formaldehyde	0-8	interleukin 6	Mus musculus	86-90
22220695-11	2012	formalin was dependent on the activation of intracellular MAPKs p38, JNK and PKC.	Formaldehyde	0-8	mitogen-activated protein kinase 14	Mus musculus	64-67
22220695-11	2012	formalin was dependent on the activation of intracellular MAPKs p38, JNK and PKC.	Formaldehyde	0-8	mitogen-activated protein kinase 8	Mus musculus	69-72
22702496-2	2012	MATERIALS AND METHODS: The CD44+/CD24- CSC ratio was determined in formalin-fixed, paraffin-embedded breast cancer tissues from 1350 breast cancer patients by double immunofluorescence staining.	Formaldehyde	67-75	CD44 molecule (Indian blood group)	Homo sapiens	27-31
22418702-4	2012	Therefore, we screened 99 primary breast cancer samples by immunohistochemistry analysis using formalin-fixed paraffin-embedded archival tumor tissues and confirmed that mesothelin was overexpressed in the majority of TNBC (67 %) but only rarely in &lt;5 % ER(+) or Her2-neu(+) breast cancer, respectively.	Formaldehyde	95-103	mesothelin	Homo sapiens	170-180
22555092-3	2012	Quantitative, methylation-specific (HeavyMethyl), real-time polymerase chain reaction assays were used to measure DNA methylation of PITX2 and SHOX2 in bisulfite-converted DNA from formalin-fixed, paraffin-embedded tissues from 474 non-small-cell lung cancer patients.	Formaldehyde	181-189	short stature homeobox 2	Homo sapiens	143-148
22555094-0	2012	Applicability of a System for fully automated nucleic acid extraction from formalin-fixed paraffin-embedded sections for routine KRAS mutation testing.	Formaldehyde	75-83	KRAS proto-oncogene, GTPase	Homo sapiens	129-133
22426079-0	2012	Competitive allele specific TaqMan PCR for KRAS, BRAF and EGFR mutation detection in clinical formalin fixed paraffin embedded samples.	Formaldehyde	94-102	epidermal growth factor receptor	Homo sapiens	58-62
22665686-7	2012	For each patient, O(6)-methylguanine-DNA methyltransferase methylation status was investigated with genomic DNA from formalin-fixed or paraffin-embedded sections of tumour tissues by methylation-specific polymerase chain reaction.	Formaldehyde	117-125	O-6-methylguanine-DNA methyltransferase	Homo sapiens	18-58
22473700-5	2012	Immunohistochemistry on formalin-fixed paraffin-embedded tissues was performed using monoclonal antibodies for CD117/c-kit.	Formaldehyde	24-32	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	111-116
23360043-4	2012	Immunohistochemical staining for p53 was performed on formalin fixed paraffin embedded tissue sections with appropriate positive and negative control.	Formaldehyde	54-62	tumor protein p53	Homo sapiens	33-36
22870594-2	2012	A study was conducted at the Department of Pathology, University of Malaya Medical Centre to determine the expression of CD133 in 56 archived, formalin-fixed, paraffin-embedded colorectal adenocarcinoma in comparison with adjacent benign colorectal epithelium by immunohistochemical staining for CD133 expression.	Formaldehyde	143-151	prominin 1	Homo sapiens	121-126
23110010-2	2012	METHODS: We analyzed the frequency of BRAF mutation in patients with primary cutaneous melanoma (n=58) or non-cutaneous one (n=27) by performing dual priming oligonucleotide-based multiplex real-time polymerase chain reaction to isolate and to purify the DNA from the formalin-fixed and paraffin-embedded tumors.	Formaldehyde	268-276	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	38-42
22342837-0	2012	Induction of endoplasmic reticulum stress and the modulation of thioredoxin-1 in formaldehyde-induced neurotoxicity.	Formaldehyde	81-93	thioredoxin 1	Rattus norvegicus	64-77
22969965-0	2012	Clinical and prognostic significance of miR-155 and miR-146a expression levels in formalin-fixed/paraffin-embedded tissue of patients with diffuse large B-cell lymphoma.	Formaldehyde	82-90	microRNA 155	Homo sapiens	40-47
22647525-3	2012	METHODS: The HER2 gene-protein assay was optimized using formalin-fixed, paraffin-embedded (FFPE) samples of the xenograft tumors MCF7 [HER2 negative (non-amplified gene, protein negative)] and Calu-3 [HER2 positive (amplified gene, protein positive)].	Formaldehyde	57-65	erb-b2 receptor tyrosine kinase 2	Homo sapiens	13-17
22490335-5	2012	This miRNA classifier showed consistent results in formalin-fixed paraffin-embedded tissues and was able to distinguish cyclin D1-negative MCL from other lymphomas.	Formaldehyde	51-59	cyclin D1	Homo sapiens	120-129
22521889-1	2012	A series of inhibitors of d-amino acid oxidase (DAAO) are specific in blocking chronic pain, including formalin-induced tonic pain, neuropathic pain and bone cancer pain.	Formaldehyde	103-111	D-amino-acid oxidase	Rattus norvegicus	48-52
22521889-2	2012	This study used RNA interference technology to further validate the notion that spinal DAAO mediates formalin-induced pain.	Formaldehyde	101-109	D-amino-acid oxidase	Rattus norvegicus	87-91
22521889-6	2012	Meanwhile, both siRNA/DAAO and Ad-shDAAO prevented formalin-induced tonic phase pain by approximately 60%.	Formaldehyde	51-59	D-amino-acid oxidase	Rattus norvegicus	22-26
22554165-0	2012	Selected Reaction Monitoring (SRM) Analysis of Epidermal Growth Factor Receptor (EGFR) in Formalin Fixed Tumor Tissue.	Formaldehyde	90-98	epidermal growth factor receptor	Homo sapiens	47-79
22554165-0	2012	Selected Reaction Monitoring (SRM) Analysis of Epidermal Growth Factor Receptor (EGFR) in Formalin Fixed Tumor Tissue.	Formaldehyde	90-98	epidermal growth factor receptor	Homo sapiens	81-85
22554165-9	2012	The assay was analytically validated against a collection of tissue culture cell lines where SRM analysis of the formalin fixed cells accurately reflects EGFR protein levels in matching non-formalin fixed cultures as established by ELISA sandwich immunoassay (R2 = 0.9991).	Formaldehyde	113-121	epidermal growth factor receptor	Homo sapiens	154-158
22523206-0	2012	The effect of 96-hour formalin fixation on the immunohistochemical evaluation of estrogen receptor, progesterone receptor, and HER2 expression in invasive breast carcinoma.	Formaldehyde	22-30	estrogen receptor 1	Homo sapiens	81-98
22523206-0	2012	The effect of 96-hour formalin fixation on the immunohistochemical evaluation of estrogen receptor, progesterone receptor, and HER2 expression in invasive breast carcinoma.	Formaldehyde	22-30	progesterone receptor	Homo sapiens	100-121
22523206-0	2012	The effect of 96-hour formalin fixation on the immunohistochemical evaluation of estrogen receptor, progesterone receptor, and HER2 expression in invasive breast carcinoma.	Formaldehyde	22-30	erb-b2 receptor tyrosine kinase 2	Homo sapiens	127-131
22159627-3	2012	METHODS: In our study, protein expression levels of SGLT1 were explored by semiquantitative immunohistochemical staining on archival formalin-fixed paraffin-embedded pathologic specimen consisting of 178 epithelial ovarian tumors.	Formaldehyde	133-141	major facilitator superfamily domain containing 4B	Homo sapiens	52-57
22480210-1	2012	The expression of the plasma membrane Ca(2+) ATPase (PMCA) was analyzed in a series of 84 formalin-fixed and paraffin embedded colon samples including normal mucosa (n = 32), adenoma (n = 19), adenocarcinoma (n = 27), and lymph node metastasis (n = 6) using (i) immunohistochemistry, (ii) mRNA in situ hybridization, and (iii) quantitative reverse-transcriptase PCR.	Formaldehyde	90-98	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	22-51
22480210-1	2012	The expression of the plasma membrane Ca(2+) ATPase (PMCA) was analyzed in a series of 84 formalin-fixed and paraffin embedded colon samples including normal mucosa (n = 32), adenoma (n = 19), adenocarcinoma (n = 27), and lymph node metastasis (n = 6) using (i) immunohistochemistry, (ii) mRNA in situ hybridization, and (iii) quantitative reverse-transcriptase PCR.	Formaldehyde	90-98	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	53-57
22647525-0	2012	A gene-protein assay for human epidermal growth factor receptor 2 (HER2): brightfield tricolor visualization of HER2 protein, the HER2 gene, and chromosome 17 centromere (CEN17) in formalin-fixed, paraffin-embedded breast cancer tissue sections.	Formaldehyde	181-189	erb-b2 receptor tyrosine kinase 2	Homo sapiens	25-65
22647525-0	2012	A gene-protein assay for human epidermal growth factor receptor 2 (HER2): brightfield tricolor visualization of HER2 protein, the HER2 gene, and chromosome 17 centromere (CEN17) in formalin-fixed, paraffin-embedded breast cancer tissue sections.	Formaldehyde	181-189	erb-b2 receptor tyrosine kinase 2	Homo sapiens	67-71
22647525-0	2012	A gene-protein assay for human epidermal growth factor receptor 2 (HER2): brightfield tricolor visualization of HER2 protein, the HER2 gene, and chromosome 17 centromere (CEN17) in formalin-fixed, paraffin-embedded breast cancer tissue sections.	Formaldehyde	181-189	erb-b2 receptor tyrosine kinase 2	Homo sapiens	112-116
22647525-0	2012	A gene-protein assay for human epidermal growth factor receptor 2 (HER2): brightfield tricolor visualization of HER2 protein, the HER2 gene, and chromosome 17 centromere (CEN17) in formalin-fixed, paraffin-embedded breast cancer tissue sections.	Formaldehyde	181-189	erb-b2 receptor tyrosine kinase 2	Homo sapiens	112-116
22640699-0	2012	Ethyl pyruvate attenuates formalin-induced inflammatory nociception by inhibiting neuronal ERK phosphorylation.	Formaldehyde	26-34	Eph receptor B1	Rattus norvegicus	91-94
22640699-6	2012	EP also attenuated the phosphorylation of extracellular signal-regulated kinase (ERK) in the neurons of L4-L5 spinal dorsal horn after formalin injection.	Formaldehyde	135-143	Eph receptor B1	Rattus norvegicus	42-79
22640699-6	2012	EP also attenuated the phosphorylation of extracellular signal-regulated kinase (ERK) in the neurons of L4-L5 spinal dorsal horn after formalin injection.	Formaldehyde	135-143	Eph receptor B1	Rattus norvegicus	81-84
22640699-8	2012	administration of PD98059, an ERK upstream kinase (MEK) inhibitor, completely blocked the formalin-induced inflammatory nociceptive responses.	Formaldehyde	90-98	Eph receptor B1	Rattus norvegicus	30-33
22740817-0	2012	Detecting BRAF Mutations in Formalin-Fixed Melanoma: Experiences with Two State-of-the-Art Techniques.	Formaldehyde	28-36	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	10-14
22969965-0	2012	Clinical and prognostic significance of miR-155 and miR-146a expression levels in formalin-fixed/paraffin-embedded tissue of patients with diffuse large B-cell lymphoma.	Formaldehyde	82-90	microRNA 146a	Homo sapiens	52-60
22335622-2	2012	METHODS AND RESULTS: We performed anti-Ki67 immunostaining (MIB-1 antibody) of formalin-fixed and paraffin-embedded tumour tissue specimens of 128 patients with newly diagnosed AOT that were treated in a randomized Phase III trial.	Formaldehyde	79-87	MIB E3 ubiquitin protein ligase 1	Homo sapiens	60-65
22006578-0	2012	TS and DPD mRNA levels on formalin-fixed paraffin-embedded specimens as predictors for distant recurrence of rectal cancer treated with preoperative chemoradiotherapy.	Formaldehyde	26-34	thymidylate synthetase	Homo sapiens	0-2
22414609-0	2012	Implementation of formalin-fixed, paraffin-embedded cell line pellets as high-quality process controls in quality assessment programs for KRAS mutation analysis.	Formaldehyde	18-26	KRAS proto-oncogene, GTPase	Homo sapiens	138-142
22006578-0	2012	TS and DPD mRNA levels on formalin-fixed paraffin-embedded specimens as predictors for distant recurrence of rectal cancer treated with preoperative chemoradiotherapy.	Formaldehyde	26-34	dihydropyrimidine dehydrogenase	Homo sapiens	7-10
22888635-5	2012	Detection of mutant K-RAS in DNA of clinical specimens (tumor tissues, formalin-fixed paraffin-embedded samples) reveals equal, at least, sensitivity of this method as compared with the HRMA and much higher as compared with Sanger sequencing.	Formaldehyde	71-79	KRAS proto-oncogene, GTPase	Homo sapiens	20-25
22722791-3	2012	METHODS: We developed an assay system for the detection of EML4-ALK variants 1, 2, 3a, 3b, 4, 5a, 5b, 6, or 7 transcripts in total RNA obtained from formalin-fixed, paraffin-embedded (FFPE) specimens of NSCLC tissue.	Formaldehyde	149-157	EMAP like 4	Homo sapiens	59-63
22722791-3	2012	METHODS: We developed an assay system for the detection of EML4-ALK variants 1, 2, 3a, 3b, 4, 5a, 5b, 6, or 7 transcripts in total RNA obtained from formalin-fixed, paraffin-embedded (FFPE) specimens of NSCLC tissue.	Formaldehyde	149-157	ALK receptor tyrosine kinase	Homo sapiens	64-67
22172726-0	2012	Proteome analysis of laser microdissected glomeruli from formalin-fixed paraffin-embedded kidneys of autopsies of diabetic patients: nephronectin is associated with the development of diabetic glomerulosclerosis.	Formaldehyde	57-65	nephronectin	Homo sapiens	133-145
22524657-2	2012	It could detect HLA-A, -B, and -C antigens in formalin-fixed paraffin embedded tissues.	Formaldehyde	46-54	major histocompatibility complex, class I, A	Homo sapiens	16-33
22451486-2	2012	Using the glucocorticoid receptor (GR) as a model factor for transcriptional initiation, we classified chromatin structure through formaldehyde-assisted isolation of regulatory elements (FAIRE).	Formaldehyde	131-143	nuclear receptor subfamily 3 group C member 1	Homo sapiens	10-33
22451486-2	2012	Using the glucocorticoid receptor (GR) as a model factor for transcriptional initiation, we classified chromatin structure through formaldehyde-assisted isolation of regulatory elements (FAIRE).	Formaldehyde	131-143	nuclear receptor subfamily 3 group C member 1	Homo sapiens	35-37
22643842-0	2012	Dramatic reduction of sequence artefacts from DNA isolated from formalin-fixed cancer biopsies by treatment with uracil- DNA glycosylase.	Formaldehyde	64-72	uracil DNA glycosylase	Homo sapiens	113-136
22420360-7	2012	Rats that received the NR2B antagonist Ro 25-6981 before and after formalin injection showed significantly reduced pain responses in the formalin test, as compared with female control rats (p&amp;lt;0.05).	Formaldehyde	67-75	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	23-27
22420360-7	2012	Rats that received the NR2B antagonist Ro 25-6981 before and after formalin injection showed significantly reduced pain responses in the formalin test, as compared with female control rats (p&amp;lt;0.05).	Formaldehyde	137-145	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	23-27
22420360-9	2012	Taken together, these results suggest that cortical antagonism of the NR2B subunit of NMDA receptors is able to reduce inflammatory pain levels not only before, but after the formalin injection in females at different phases of the estrous cycle.	Formaldehyde	175-183	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	70-74
22261801-8	2012	We identify multiple differentially methylated regions, including one in ERBB2 and one in ZEB2, whose methylation status is strongly associated with an epithelial phenotype in NSCLC cell lines, surgically resected tumors, and formalin-fixed biopsies from patients with NSCLC who went on to fail front-line chemotherapy.	Formaldehyde	226-234	erb-b2 receptor tyrosine kinase 2	Homo sapiens	73-78
22226716-6	2012	The formaldehyde uptake capacity by hectorite-TiO(2) was 4.1 times higher than that of P25, almost twice the BET surface area ratio.	Formaldehyde	4-16	tubulin polymerization promoting protein	Homo sapiens	87-90
22261801-8	2012	We identify multiple differentially methylated regions, including one in ERBB2 and one in ZEB2, whose methylation status is strongly associated with an epithelial phenotype in NSCLC cell lines, surgically resected tumors, and formalin-fixed biopsies from patients with NSCLC who went on to fail front-line chemotherapy.	Formaldehyde	226-234	zinc finger E-box binding homeobox 2	Homo sapiens	90-94
22226716-6	2012	The formaldehyde uptake capacity by hectorite-TiO(2) was 4.1 times higher than that of P25, almost twice the BET surface area ratio.	Formaldehyde	4-16	delta/notch like EGF repeat containing	Homo sapiens	109-112
22179975-4	2012	The aim of the present study was to develop a method for the detection of chimeric PAX8-PPARG transcripts in formalin-fixed paraffin-embedded (FFPE) thyroid tumor samples by conventional RT-PCR.	Formaldehyde	109-117	paired box 8	Homo sapiens	83-87
22081168-8	2012	In contrast, formalin-induced Fos does not co-localize with TIP39.	Formaldehyde	13-21	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	30-33
22081168-9	2012	Instead, most formalin-activated neurons are situated medial to the TIP39 cell group.	Formaldehyde	14-22	parathyroid hormone 2	Rattus norvegicus	68-73
21985563-4	2012	In a formalin test, Gc-TSP significantly reduced licking time in both phases of the test at a dose of 27 mg/kg.	Formaldehyde	5-13	CTR9 homolog, Paf1/RNA polymerase II complex component	Mus musculus	23-26
22058222-4	2012	Interleukin-17A-producing cells were analyzed in formalin-fixed, paraffin-embedded spleen and lymph node sections using immunohistochemistry and immunofluorescence.	Formaldehyde	49-57	interleukin 17A	Homo sapiens	0-15
22179975-4	2012	The aim of the present study was to develop a method for the detection of chimeric PAX8-PPARG transcripts in formalin-fixed paraffin-embedded (FFPE) thyroid tumor samples by conventional RT-PCR.	Formaldehyde	109-117	peroxisome proliferator activated receptor gamma	Homo sapiens	88-93
22397399-4	2012	In situ hybridization (ISH) was performed to detect miRNA-126 in formalin-fixed paraffin embedded tissue from primary tumours.	Formaldehyde	65-73	microRNA 126	Homo sapiens	52-61
22201038-10	2012	administration of low doses of AM251 per se significantly decreased both pain related behavior and spinal IL1-beta expression in formalin test.	Formaldehyde	129-137	interleukin 1 beta	Rattus norvegicus	106-114
22466127-0	2012	Formaldehyde up-regulates TRPV1 through MAPK and PI3K signaling pathways in a rat model of bone cancer pain.	Formaldehyde	0-12	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	26-31
22466127-1	2012	OBJECTIVE: Our previous study showed that tumor tissue-derived formaldehyde at low concentrations plays an important role in bone cancer pain through activating transient receptor potential vanilloid subfamily member 1 (TRPV1).	Formaldehyde	63-75	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	220-225
22466127-2	2012	The present study further explored whether this tumor tissue-derived endogenous formaldehyde regulates TRPV1 expression in a rat model of bone cancer pain, and if so, what the possible signal pathways are during the development of this type of pain.	Formaldehyde	80-92	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	103-108
22466127-8	2012	In primary cultured DRG neurons, 100 mumol/L formaldehyde significantly increased the TRPV1 expression level.	Formaldehyde	45-57	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	86-91
22466127-9	2012	Pre-incubation with PD98059, SB203580, SP600125 or LY294002, but not BIM, inhibited the formaldehyde-induced increase of TRPV1 expression.	Formaldehyde	88-100	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	121-126
22466127-10	2012	CONCLUSION: Formaldehyde at a very low concentration up-regulates TRPV1 expression through mitogen-activated protein kinase and PI3K, but not PKC, signaling pathways.	Formaldehyde	12-24	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	66-71
22376167-5	2012	The BRAF V600E mutations were detected using direct sequencing of genomic DNA that was isolated from formalin-fixed paraffin-embedded tumor tissues.	Formaldehyde	101-109	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	4-8
22423113-5	2012	While wild-type and TRPM2 knock-out mice showed no difference in their basal sensitivity to mechanical and thermal stimulation, nocifensive behaviors in the formalin test were reduced in TRPM2 knock-out mice.	Formaldehyde	157-165	transient receptor potential cation channel, subfamily M, member 2	Mus musculus	187-192
22258934-4	2012	This formaldehyde-oxidizing capacity of astrocyte cultures is likely to be catalyzed by alcohol dehydrogenase 3 and aldehyde dehydrogenase 2, because the cells of the cultures contain the mRNAs of these formaldehyde-oxidizing enzymes.	Formaldehyde	5-17	aldehyde dehydrogenase 2 family member	Homo sapiens	116-140
22258934-4	2012	This formaldehyde-oxidizing capacity of astrocyte cultures is likely to be catalyzed by alcohol dehydrogenase 3 and aldehyde dehydrogenase 2, because the cells of the cultures contain the mRNAs of these formaldehyde-oxidizing enzymes.	Formaldehyde	203-215	aldehyde dehydrogenase 2 family member	Homo sapiens	116-140
22558613-0	2012	Participation of microglial p38 MAPK in formalin-induced temporomandibular joint nociception in rats.	Formaldehyde	40-48	mitogen activated protein kinase 14	Rattus norvegicus	28-31
22558613-5	2012	RESULTS: The intra-articular injection of formalin increased the expression of p-p38 MAPK in the ipsilateral medullary dorsal horn.	Formaldehyde	42-50	mitogen activated protein kinase 14	Rattus norvegicus	81-84
22953501-2	2012	METHODS AND RESULTS: We used immunohistochemical techniques to evaluate monoclonal antibodies against CD2AP on over 400 formalin fixed paraffin embedded tissue blocks retrieved from the host institutions of three authors.	Formaldehyde	120-128	CD2 associated protein	Homo sapiens	102-107
22764592-14	2012	The inflammatory cells in the formalin-injected thyroid region were relatively fewer in the LI 18 and LI 4-PC 6 groups than in the model group.	Formaldehyde	30-38	proprotein convertase subtilisin/kexin type 5	Rattus norvegicus	107-111
22764592-15	2012	CONCLUSION: Both EA of LI 18 and LI 4-PC 6 can significantly suppress formalin-injection induced pain reactions in the thyroid region, which may be closely associated with its effects in upregulating expression levels of cervico-spinal GABA(B) R1 mRNA, GABA(B) R2 mRNA and GABA(A) R mRNA, and reduce regional inflammatory reactions in the thyroid region.	Formaldehyde	70-78	proprotein convertase subtilisin/kexin type 5	Rattus norvegicus	38-42
22764592-15	2012	CONCLUSION: Both EA of LI 18 and LI 4-PC 6 can significantly suppress formalin-injection induced pain reactions in the thyroid region, which may be closely associated with its effects in upregulating expression levels of cervico-spinal GABA(B) R1 mRNA, GABA(B) R2 mRNA and GABA(A) R mRNA, and reduce regional inflammatory reactions in the thyroid region.	Formaldehyde	70-78	gamma-aminobutyric acid type B receptor subunit 1	Rattus norvegicus	236-246
22764592-15	2012	CONCLUSION: Both EA of LI 18 and LI 4-PC 6 can significantly suppress formalin-injection induced pain reactions in the thyroid region, which may be closely associated with its effects in upregulating expression levels of cervico-spinal GABA(B) R1 mRNA, GABA(B) R2 mRNA and GABA(A) R mRNA, and reduce regional inflammatory reactions in the thyroid region.	Formaldehyde	70-78	gamma-aminobutyric acid type B receptor subunit 2	Rattus norvegicus	253-263
22436573-3	2012	METHODS: We investigated the mRNA and protein expression of ERCC1 and RRM1 by RT-PCR and immunohistochemistry (IHC) in formalin-fixed, paraffin-embedded pancreatic ductal carcinoma (PDA) tissues.	Formaldehyde	119-127	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	60-65
22436573-3	2012	METHODS: We investigated the mRNA and protein expression of ERCC1 and RRM1 by RT-PCR and immunohistochemistry (IHC) in formalin-fixed, paraffin-embedded pancreatic ductal carcinoma (PDA) tissues.	Formaldehyde	119-127	ribonucleotide reductase catalytic subunit M1	Homo sapiens	70-74
21950354-0	2012	D-Amino acid oxidase-mediated increase in spinal hydrogen peroxide is mainly responsible for formalin-induced tonic pain.	Formaldehyde	93-101	D-amino acid oxidase	Homo sapiens	0-20
21950354-8	2012	Given systemically, the potent DAAO inhibitor CBIO (5-chloro-benzo[d]isoxazol-3-ol) blocked spinal DAAO enzymatic activity and specifically prevented formalin-induced tonic pain in a dose-dependent manner.	Formaldehyde	150-158	D-amino acid oxidase	Homo sapiens	31-35
21835426-8	2012	Thus, detection of the ASPSCR1-TFE3 fusion transcript was considered applicable for formalin-fixed, paraffin-embedded tissues with superior sensitivity as compared with TFE3 immunohistochemical staining.	Formaldehyde	84-92	ASPSCR1 tether for SLC2A4, UBX domain containing	Homo sapiens	23-30
22186232-0	2012	Formaldehyde-induced genome instability is suppressed by an XPF-dependent pathway.	Formaldehyde	0-12	DNA repair endonuclease XPF	Cricetulus griseus	60-63
22186232-4	2012	Herein, investigations of genes that modulate the cytotoxic effects of formaldehyde exposure revealed that of five NER-deficient Chinese Hamster Ovary (CHO) cell lines tested, XPF- and ERCC1-deficient cells were most sensitive to formaldehyde treatment as compared to wild-type cells.	Formaldehyde	71-83	DNA repair endonuclease XPF	Cricetulus griseus	176-180
22186232-4	2012	Herein, investigations of genes that modulate the cytotoxic effects of formaldehyde exposure revealed that of five NER-deficient Chinese Hamster Ovary (CHO) cell lines tested, XPF- and ERCC1-deficient cells were most sensitive to formaldehyde treatment as compared to wild-type cells.	Formaldehyde	71-83	DNA excision repair protein ERCC-1	Cricetulus griseus	185-190
22186232-4	2012	Herein, investigations of genes that modulate the cytotoxic effects of formaldehyde exposure revealed that of five NER-deficient Chinese Hamster Ovary (CHO) cell lines tested, XPF- and ERCC1-deficient cells were most sensitive to formaldehyde treatment as compared to wild-type cells.	Formaldehyde	230-242	DNA repair endonuclease XPF	Cricetulus griseus	176-180
22186232-4	2012	Herein, investigations of genes that modulate the cytotoxic effects of formaldehyde exposure revealed that of five NER-deficient Chinese Hamster Ovary (CHO) cell lines tested, XPF- and ERCC1-deficient cells were most sensitive to formaldehyde treatment as compared to wild-type cells.	Formaldehyde	230-242	DNA excision repair protein ERCC-1	Cricetulus griseus	185-190
22186232-7	2012	Formaldehyde-induced DSBs occurred in a replication-dependent, but an XPF-independent manner.	Formaldehyde	0-12	DNA repair endonuclease XPF	Cricetulus griseus	70-73
22186232-9	2012	Collectively, our findings highlight the role of an XPF-dependent pathway in mitigating the sensitivity to formaldehyde-induced DNA damage as evidenced by the increased genomic instability and reduced cell viability in an XPF-deficient background.	Formaldehyde	107-119	DNA repair endonuclease XPF	Cricetulus griseus	52-55
21800286-3	2012	METHODS: Total FAK expression was analyzed via immunohistochemistry in tissue microarrays consisting of formalin-fixed, paraffin-embedded SCLC specimens from 85 patients.	Formaldehyde	104-112	protein tyrosine kinase 2	Homo sapiens	15-18
22290557-9	2012	In the TCC, the increase in formalin-induced Fos immunoreactivity was significantly attenuated in the memantine group (p &lt; 0.01).	Formaldehyde	28-36	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	45-48
21835426-8	2012	Thus, detection of the ASPSCR1-TFE3 fusion transcript was considered applicable for formalin-fixed, paraffin-embedded tissues with superior sensitivity as compared with TFE3 immunohistochemical staining.	Formaldehyde	84-92	transcription factor binding to IGHM enhancer 3	Homo sapiens	31-35
22737922-7	2012	The number and staining degree of HO-1 immunoreactive cells were further increased at 12 h and peaked at 1 d after formalin injection.	Formaldehyde	115-123	heme oxygenase 1	Rattus norvegicus	34-38
22649925-0	2012	Determination of naturally occurring formaldehyde levels in sap and wood tissue of maple trees using gas chromatgraphy/mass spectrometry.	Formaldehyde	37-49	SH2 domain containing 1A	Homo sapiens	60-63
22649925-1	2012	The occurrence of formaldehyde in sap and wood tissue of treated and untreated maple sugar trees was investigated using GC/MS.	Formaldehyde	18-30	SH2 domain containing 1A	Homo sapiens	34-37
22737922-0	2012	[Effect of formalin inflammatory pain on expression of HO-1 in spinal cord of rats].	Formaldehyde	11-19	heme oxygenase 1	Rattus norvegicus	55-59
22737922-1	2012	OBJECTIVE: To investigate whether formalin inflammatory pain can induce the change in heme oxygenase-1 (HO-1) expression in the spinal cord of rats or not and the time course character.	Formaldehyde	34-42	heme oxygenase 1	Rattus norvegicus	86-102
22737922-1	2012	OBJECTIVE: To investigate whether formalin inflammatory pain can induce the change in heme oxygenase-1 (HO-1) expression in the spinal cord of rats or not and the time course character.	Formaldehyde	34-42	heme oxygenase 1	Rattus norvegicus	104-108
22649925-3	2012	The natural concentration of formaldehyde found in untreated samples varied according to periods and locations and ranged from below the LOQ to 1.82 mg/kg for sap samples and from 2.39 to 8.92 mg/kg of fresh tissue for wood samples.	Formaldehyde	29-41	SH2 domain containing 1A	Homo sapiens	159-162
22649925-5	2012	Samples of sap and wood tissue from tapholes treated with solutions of formaldehyde showed increased concentrations of formaldehyde for many days after treatment and were clearly distinct from untreated samples.	Formaldehyde	71-83	SH2 domain containing 1A	Homo sapiens	11-14
22649925-5	2012	Samples of sap and wood tissue from tapholes treated with solutions of formaldehyde showed increased concentrations of formaldehyde for many days after treatment and were clearly distinct from untreated samples.	Formaldehyde	119-131	SH2 domain containing 1A	Homo sapiens	11-14
22331132-11	2012	MDR3 immunostainings performed on formalin-fixed paraffin-embedded sections showed a strong canalicular staining in all patients except in one.	Formaldehyde	34-42	ATP binding cassette subfamily B member 4	Homo sapiens	0-4
22737922-6	2012	Comparing with control group, the numbers of HO-1 immunoreactive cells in the I - II laminae of dorsal horn and area around canalis centralis were increased in the rats at 6 h after formalin injection.	Formaldehyde	182-190	heme oxygenase 1	Rattus norvegicus	45-49
22357131-7	2012	METHODS: In this study, we examined NAIP protein expression in 101 Formalin-Fixed Paraffin-Embedded blocks including samples from 39 Hodgkin Lymphoma and 23 Non Hodgkin Lymphoma cases in comparison with 39 control samples (30 normal and 9 Reactive Lymphoid Hyperplasia (RLH) lymph nodes) using semi-quantitative immuno-flourecent Staining.	Formaldehyde	67-75	NLR family apoptosis inhibitory protein	Homo sapiens	36-40
22737922-10	2012	CONCLUSION: Formalin inflammatory pain induced increased expression of HO-1 in the spinal cord dorsal horn and the area around canalis centralis of rats.	Formaldehyde	12-20	heme oxygenase 1	Rattus norvegicus	71-75
22737922-11	2012	At 1 d after injection of formalin, the increased expression of HO-1 was the most obviously.	Formaldehyde	26-34	heme oxygenase 1	Rattus norvegicus	64-68
22138297-0	2012	MAPK- and PKC/CREB-dependent induction of interleukin-11 by the environmental contaminant formaldehyde in human bronchial epithelial cells.	Formaldehyde	90-102	proline rich transmembrane protein 2	Homo sapiens	10-13
22273571-4	2012	We conducted immunohistochemical studies on XIAP in formalin-fixed, paraffin-embedded sections from eight normal participants, 10 patients with Parkinson"s disease, five patients with dementia with Lewy bodies, and seven patients with Alzheimer"s disease, and then double-labeling immunohistochemistry for XIAP and HtrA2/Omi in sections from the Parkinson"s disease and dementia with Lewy bodies cases.	Formaldehyde	52-60	X-linked inhibitor of apoptosis	Homo sapiens	44-48
22138297-0	2012	MAPK- and PKC/CREB-dependent induction of interleukin-11 by the environmental contaminant formaldehyde in human bronchial epithelial cells.	Formaldehyde	90-102	cAMP responsive element binding protein 1	Homo sapiens	14-18
22138297-0	2012	MAPK- and PKC/CREB-dependent induction of interleukin-11 by the environmental contaminant formaldehyde in human bronchial epithelial cells.	Formaldehyde	90-102	interleukin 11	Homo sapiens	42-56
22233892-9	2012	CONCLUSION: Either the glycine site or the GluN2B subunit of NMDARs participates in the phosphorylation of ERK and CREB induced by bath application of NMDA in brain slices or hindpaw injection of 5% formalin in rats, and these might be fundamental molecular mechanisms underlying pain affect.	Formaldehyde	199-207	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	43-49
21948527-6	2012	Antisense vectors inhibited formalin-evoked c-Fos expression in the spinal cord, indicating decreased nociceptive activity of spinal neurons.	Formaldehyde	28-36	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	44-49
21598109-4	2012	Moreover, expressions of HMGA2 were performed by western blotting and further confirmed by 150 paired of formalin-fixed, paraffin-embeded (FFPE) ESCC and NAT by immunohistochemistry (IHC).	Formaldehyde	105-113	high mobility group AT-hook 2	Homo sapiens	25-30
22233892-9	2012	CONCLUSION: Either the glycine site or the GluN2B subunit of NMDARs participates in the phosphorylation of ERK and CREB induced by bath application of NMDA in brain slices or hindpaw injection of 5% formalin in rats, and these might be fundamental molecular mechanisms underlying pain affect.	Formaldehyde	199-207	Eph receptor B1	Rattus norvegicus	107-110
22137657-7	2012	injection of DHA (25 and 50mug/mouse) and GW9508 (a GPR40- and GPR120-selective agonist; 0.1 and 1.0mug/mouse) significantly reduced formalin-induced pain behavior.	Formaldehyde	133-141	free fatty acid receptor 1	Mus musculus	52-57
22173329-0	2012	Analytical performance of a PCR assay for the detection of KRAS mutations (codons 12/13 and 61) in formalin-fixed paraffin-embedded tissue samples of colorectal carcinoma.	Formaldehyde	99-107	KRAS proto-oncogene, GTPase	Homo sapiens	59-63
22061687-1	2012	This study investigated the antinociceptive effect of intrathecal escin and examined its effect on the formalin-induced activation of c-Fos and phosphorylated p38 mitogen-activated protein kinase (p-p38 MAPK) in the rat spinal cord.	Formaldehyde	103-111	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	134-139
22061687-1	2012	This study investigated the antinociceptive effect of intrathecal escin and examined its effect on the formalin-induced activation of c-Fos and phosphorylated p38 mitogen-activated protein kinase (p-p38 MAPK) in the rat spinal cord.	Formaldehyde	103-111	mitogen activated protein kinase 14	Rattus norvegicus	159-195
22061687-5	2012	In addition, immunohistochemical experiments showed that the expression of c-Fos and p-p38 MAPK in the spinal cord dorsal horn increased after an injection of formalin into the paw.	Formaldehyde	159-167	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	75-80
22061687-6	2012	Interestingly, the 40mug dose of intrathecal escin, which was the larger of the two doses that blocked formalin-induced hyperalgaesia, attenuated the formalin-induced increases in c-Fos and p-p38 MAPK in the dorsal horn of the spinal cord.	Formaldehyde	150-158	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	180-185
22240294-6	2012	METHODS: By means of immunohistochemistry and quantitative real-time PCR, we determined SGK1 protein and mRNA expression in a cohort of 66 formalin-fixed, paraffin-embedded NSCLC surgical samples.	Formaldehyde	139-147	serum/glucocorticoid regulated kinase 1	Homo sapiens	88-92
22358180-1	2012	A commentary on: analytical performance of a PCR assay for the detection of KRAS mutations (codons 12/13 and 61) in formalin-fixed paraffin-embedded tissue samples of colorectal carcinoma, by Lee et al.	Formaldehyde	116-124	KRAS proto-oncogene, GTPase	Homo sapiens	76-80
22169772-7	2012	Cu2(fen)4(caf)2 and Cu2(fen)4(dmf)2 significantly decreased the acetic acid-induced writhing response and the licking time on the late phase in the formalin test with respect to the control and fenoprofen salt groups.	Formaldehyde	148-156	immunoglobulin kappa variable 1-35	Mus musculus	0-15
22169772-7	2012	Cu2(fen)4(caf)2 and Cu2(fen)4(dmf)2 significantly decreased the acetic acid-induced writhing response and the licking time on the late phase in the formalin test with respect to the control and fenoprofen salt groups.	Formaldehyde	148-156	immunoglobulin kappa variable 1-35	Mus musculus	0-3
22224423-2	2012	Here, using a formaldehyde-based in vivo cross-linking and chromatin immunoprecipitation (ChIP) assay in conjunction with transcriptional and mutational analyses, we show that Sgf29p along with other SAGA components is recruited to the upstream activating sequence (UAS) of a SAGA-regulated gene, GAL1, in an activation domain-dependent manner.	Formaldehyde	14-26	SAGA complex associated factor 29	Homo sapiens	176-182
22137657-7	2012	injection of DHA (25 and 50mug/mouse) and GW9508 (a GPR40- and GPR120-selective agonist; 0.1 and 1.0mug/mouse) significantly reduced formalin-induced pain behavior.	Formaldehyde	133-141	free fatty acid receptor 4	Mus musculus	63-69
22729110-5	2012	Moreover, the increase in c-fos mRNA expression on the formalin-injected side was less pronounced in rats administered landiolol than in saline administered controls.	Formaldehyde	55-63	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	26-31
21929847-4	2012	In this study, we have developed a novel objective method for analysis of  immune cells, including Foxp3(+) T regulatory cells (Tregs), on formalin-fixed /paraffin-embedded (FFPE) transplant biopsy sections using iCys  Research Imaging Cytometer.	Formaldehyde	139-147	forkhead box P3	Homo sapiens	99-104
21524815-10	2012	The expression of human VEGF was also checked by real-time polymerase chain reaction in formalin-fixed, paraffin-embedded tissue sections.	Formaldehyde	88-96	vascular endothelial growth factor A	Homo sapiens	24-28
22313768-0	2012	Msn5p is involved in formaldehyde resistance but not in oxidative stress response in the methylotrophic yeast Candida boidinii.	Formaldehyde	21-33	karyopherin MSN5	Saccharomyces cerevisiae S288C	0-5
22313768-2	2012	Here we report that Msn5p, an importin-beta family nuclear exporter, participated in the formaldehyde resistance mechanism but not in the hydrogen peroxide resistance mechanism in Candida boidinii.	Formaldehyde	89-101	karyopherin MSN5	Saccharomyces cerevisiae S288C	20-25
22313768-3	2012	Disruption of the MSN5 gene in this yeast caused retardation of growth on formaldehyde-generating growth substrates such as methanol and methylamine, but the expression levels of the methanol-metabolizing enzymes did not fall.	Formaldehyde	74-86	karyopherin MSN5	Saccharomyces cerevisiae S288C	18-22
22313768-4	2012	The Msn5p-depleted strain was sensitive to formaldehyde but not to hydrogen peroxide.	Formaldehyde	43-55	karyopherin MSN5	Saccharomyces cerevisiae S288C	4-9
22313768-5	2012	Furthermore, a yellow fluorescent protein-tagged Msn5p was diffuse in the cytoplasm of C. boidinii when the cells were treated with high concentrations of formaldehyde or ethanol, but was predominantly associated with the nuclei following treatment with hydrogen peroxide.	Formaldehyde	155-167	karyopherin MSN5	Saccharomyces cerevisiae S288C	49-54
22661904-1	2012	Testing for mutations in the KRAS oncogene for patients with metastatic colorectal cancer (mCRC) is generally performed using DNA from formalin-fixed paraffin-embedded tumor tissue; however, access to specimens can be limited and analysis challenging.	Formaldehyde	135-143	KRAS proto-oncogene, GTPase	Homo sapiens	29-33
23193419-6	2012	The C-ANCA pattern was recognized by routine microscopy in 92% and 97% on ethanol- and formalin-fixed slides, respectively.	Formaldehyde	87-95	proteinase 3	Homo sapiens	4-10
23193419-9	2012	Typically, only 65% and 33% of these samples showed the expected C-ANCA on formalin-fixed neutrophils by routine microscopy and AKLIDES, respectively.	Formaldehyde	75-83	proteinase 3	Homo sapiens	65-71
23193419-11	2012	Only 5% of the controls revealed C-ANCA on formalin-fixed neutrophils by routine microscopy and AKLIDES.	Formaldehyde	43-51	proteinase 3	Homo sapiens	33-39
21391216-0	2012	Profiling signalling pathways in formalin-fixed and paraffin-embedded breast cancer tissues reveals cross-talk between EGFR, HER2, HER3 and uPAR.	Formaldehyde	33-41	epidermal growth factor receptor	Homo sapiens	119-123
22081392-8	2012	Since formaldehyde transfer is a potential link between MnmEG and YgfZ, we inactivated formaldehyde detoxification by deleting frmA.	Formaldehyde	6-18	alcohol dehydrogenase class-III	Escherichia coli	127-131
22081392-8	2012	Since formaldehyde transfer is a potential link between MnmEG and YgfZ, we inactivated formaldehyde detoxification by deleting frmA.	Formaldehyde	87-99	alcohol dehydrogenase class-III	Escherichia coli	127-131
22033727-4	2012	METHODS: We investigated the expression of PTEN and phospho-Akt in 146 formalin-fixed (archived) paraffin-embedded oral squamous cell carcinoma tissue sections through immunohistochemical analysis.	Formaldehyde	71-79	phosphatase and tensin homolog	Homo sapiens	43-47
22550540-5	2012	Treatment of EA at BL60 significantly inhibited flinching behavior and c-fos expression induced by formalin injection into the paw, compared to a control group.	Formaldehyde	99-107	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	71-76
21922591-9	2012	Pyrosequencing proved a good method for assessing the degree of MGMT methylation in formalin-fixed paraffin-embedded glioma samples.	Formaldehyde	84-92	O-6-methylguanine-DNA methyltransferase	Homo sapiens	64-68
22275824-3	2012	METHODS: LMP1-functionalized 4-mercaptobenzoic acid (4-MBA)-labeled Au/Ag core-shell bimetallic nanoparticles were prepared first and then applied for analyzing LMP1 in formalin-fixed paraffin-embedded nasopharyngeal tissue sections obtained from 34 cancer patients and 20 healthy controls.	Formaldehyde	169-177	PDZ and LIM domain 7	Homo sapiens	9-13
22275824-3	2012	METHODS: LMP1-functionalized 4-mercaptobenzoic acid (4-MBA)-labeled Au/Ag core-shell bimetallic nanoparticles were prepared first and then applied for analyzing LMP1 in formalin-fixed paraffin-embedded nasopharyngeal tissue sections obtained from 34 cancer patients and 20 healthy controls.	Formaldehyde	169-177	PDZ and LIM domain 7	Homo sapiens	161-165
22275824-5	2012	RESULTS: Data from SERS spectra and images show that this new SERS-based immunoassay detected LMP1 in formalin-fixed paraffin-embedded nasopharyngeal tissue sections with high sensitivity and specificity.	Formaldehyde	102-110	PDZ and LIM domain 7	Homo sapiens	94-98
21391216-0	2012	Profiling signalling pathways in formalin-fixed and paraffin-embedded breast cancer tissues reveals cross-talk between EGFR, HER2, HER3 and uPAR.	Formaldehyde	33-41	erb-b2 receptor tyrosine kinase 2	Homo sapiens	125-129
21391216-0	2012	Profiling signalling pathways in formalin-fixed and paraffin-embedded breast cancer tissues reveals cross-talk between EGFR, HER2, HER3 and uPAR.	Formaldehyde	33-41	erb-b2 receptor tyrosine kinase 3	Homo sapiens	131-135
21391216-0	2012	Profiling signalling pathways in formalin-fixed and paraffin-embedded breast cancer tissues reveals cross-talk between EGFR, HER2, HER3 and uPAR.	Formaldehyde	33-41	plasminogen activator, urokinase receptor	Homo sapiens	140-144
22025255-6	2012	A monoclonal antibody to human NRP1 was generated and validated for immunohistochemistry by western blotting, use of formalin-fixed cell pellets transfected with NRP1, immunofluorescence, and comparison with in situ hybridization.	Formaldehyde	117-125	neuropilin 1	Homo sapiens	31-35
22302023-0	2012	Transient receptor potential vanilloid 1 - a polymodal nociceptive receptor - plays a crucial role in formaldehyde-induced skin inflammation in mice.	Formaldehyde	102-114	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-40
21926424-7	2012	Conditioned fear per se in non-formalin-treated rats was associated with increased expression of phospho-Akt in the PAG.	Formaldehyde	31-39	AKT serine/threonine kinase 1	Rattus norvegicus	105-108
21926424-9	2012	Intra-plantar injection of formalin also reduced the fear-induced increase in phospho-Akt expression.	Formaldehyde	27-35	AKT serine/threonine kinase 1	Rattus norvegicus	86-89
22106443-0	2012	DNA identification of formalin-fixed organs is affected by fixation time and type of fixatives: using the AmpF l STR(R) Identifiler(R) PCR Amplification Kit.	Formaldehyde	22-30	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	153-156
22106443-2	2012	However, few studies have been conducted to determine the detection limit of DNA typing of formalin fixation time in samples using the AmpFlSTR( ) Identifiler( ) PCR Amplification Kit (Identifiler Kit).	Formaldehyde	91-99	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	180-183
22106443-2	2012	However, few studies have been conducted to determine the detection limit of DNA typing of formalin fixation time in samples using the AmpFlSTR( ) Identifiler( ) PCR Amplification Kit (Identifiler Kit).	Formaldehyde	91-99	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	197-200
22031231-3	2012	ERCC1 expression was evaluated by immunohistochemistry (IHC) on the formalin-fixed paraffin-embedded diagnostic biopsies.	Formaldehyde	68-76	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	0-5
22234627-5	2012	HER-2 protein was quantified as total HER-2 protein expression (H2T) by the HERmark  assay (Monogram Biosciences, Inc., South San Francisco, CA) in formalin-fixed, paraffin-embedded tumor samples.	Formaldehyde	148-156	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-5
22530128-3	2012	In this paper, DNA promoter methylation of five C-terminal Ras-association family members (RASSF1A, RASSF2A, RASSF4, RASSF5, and RASSF6) was studied in 64 formalin-fixed paraffin-embedded (FFPE) bladder cancer and normal adjacent tissues using methylation-specific high-resolution melting (MS-HRM) analysis.	Formaldehyde	155-163	Ras association domain family member 1	Homo sapiens	91-98
22530128-3	2012	In this paper, DNA promoter methylation of five C-terminal Ras-association family members (RASSF1A, RASSF2A, RASSF4, RASSF5, and RASSF6) was studied in 64 formalin-fixed paraffin-embedded (FFPE) bladder cancer and normal adjacent tissues using methylation-specific high-resolution melting (MS-HRM) analysis.	Formaldehyde	155-163	Ras association domain family member 4	Homo sapiens	109-115
22530128-3	2012	In this paper, DNA promoter methylation of five C-terminal Ras-association family members (RASSF1A, RASSF2A, RASSF4, RASSF5, and RASSF6) was studied in 64 formalin-fixed paraffin-embedded (FFPE) bladder cancer and normal adjacent tissues using methylation-specific high-resolution melting (MS-HRM) analysis.	Formaldehyde	155-163	Ras association domain family member 6	Homo sapiens	129-135
23461062-5	2012	Expression levels of JWA protein in archival 292 formalin-fixed, paraffin-embedded specimens were also analyzed by immunohistochemistry.	Formaldehyde	49-57	ADP ribosylation factor like GTPase 6 interacting protein 5	Homo sapiens	21-24
22234627-5	2012	HER-2 protein was quantified as total HER-2 protein expression (H2T) by the HERmark  assay (Monogram Biosciences, Inc., South San Francisco, CA) in formalin-fixed, paraffin-embedded tumor samples.	Formaldehyde	148-156	erb-b2 receptor tyrosine kinase 2	Homo sapiens	38-43
22937151-4	2012	In addition, the number of pERK-immunoreactive (IR) cells was significantly decreased bilaterally in the Vi/Vc, Vc and C1/C2 in GluR2 delta7 KI and GluR3 delta7 KI mice compared to wild-type mice at 40 min after formalin injection, and was also significantly smaller in GluR3 delta7 KI compared to GluR2 delta7 KI mice.	Formaldehyde	212-220	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	27-31
22937151-4	2012	In addition, the number of pERK-immunoreactive (IR) cells was significantly decreased bilaterally in the Vi/Vc, Vc and C1/C2 in GluR2 delta7 KI and GluR3 delta7 KI mice compared to wild-type mice at 40 min after formalin injection, and was also significantly smaller in GluR3 delta7 KI compared to GluR2 delta7 KI mice.	Formaldehyde	212-220	glutamate receptor, ionotropic, AMPA3 (alpha 3)	Mus musculus	148-153
22937151-5	2012	The number of Fos protein-IR cells in the ipsilateral Vi/Vc, Vc and C1/C2 was also significantly smaller in GluR2 delta7 KI and GluR3 delta7 KI mice compared to wild-type mice 40 min after formalin injection.	Formaldehyde	189-197	FBJ osteosarcoma oncogene	Mus musculus	14-17
22937151-5	2012	The number of Fos protein-IR cells in the ipsilateral Vi/Vc, Vc and C1/C2 was also significantly smaller in GluR2 delta7 KI and GluR3 delta7 KI mice compared to wild-type mice 40 min after formalin injection.	Formaldehyde	189-197	glutamate receptor, ionotropic, AMPA2 (alpha 2)	Mus musculus	108-113
22879882-7	2012	Inhibition of EphBs receptors by intrathecal injection of EphB1-Fc reduced formalin-induced inflammation and chronic constrictive injury-induced neuropathic pain behaviors accompanied by decreased expression of spinal PI3K,p-AKT and c-Fos protein.	Formaldehyde	75-83	EPH receptor B1	Homo sapiens	58-63
22937151-5	2012	The number of Fos protein-IR cells in the ipsilateral Vi/Vc, Vc and C1/C2 was also significantly smaller in GluR2 delta7 KI and GluR3 delta7 KI mice compared to wild-type mice 40 min after formalin injection.	Formaldehyde	189-197	glutamate receptor, ionotropic, AMPA3 (alpha 3)	Mus musculus	128-133
22937151-7	2012	These findings suggest that GluR2 and GluR3 trafficking is involved in the enhancement of Vi/Vc, Vc and C1/C2 nociceptive neuronal excitabilities at 16-60 min following formalin injection, resulting in orofacial inflammatory pain.	Formaldehyde	169-177	glutamate receptor, ionotropic, AMPA2 (alpha 2)	Mus musculus	28-33
22937151-7	2012	These findings suggest that GluR2 and GluR3 trafficking is involved in the enhancement of Vi/Vc, Vc and C1/C2 nociceptive neuronal excitabilities at 16-60 min following formalin injection, resulting in orofacial inflammatory pain.	Formaldehyde	169-177	glutamate receptor, ionotropic, AMPA3 (alpha 3)	Mus musculus	38-43
22723849-3	2012	The expression levels of miR-196b were also validated in an independent cohort containing 128 formalin-fixed paraffin-embedded (FFPE) glioma samples using qRT-PCR.	Formaldehyde	94-102	microRNA 196b	Homo sapiens	25-33
22666347-3	2012	We report its recloning into the bivalent scFv-Fc format and further immunological and biochemical characterisation.The scFv-Fc ToR67-3B4 recognised viable as well as formalin and ss-propionolactone (ss-Pl) inactivated virus particles and could be applied for immunoblot analysis of VEEV proteins and immuno-histochemistry of VEEV infected cells.	Formaldehyde	167-175	immunglobulin heavy chain variable region	Homo sapiens	120-124
22396748-5	2012	N1-8 monoclonal antibody provided the best recognition of RB1CC1 in the clinico-pathological examination of formalin-fixed paraffin-embedded tissues.	Formaldehyde	108-116	RB1 inducible coiled-coil 1	Homo sapiens	58-64
21981997-14	2011	In conclusion, this study demonstrates that the antibodies generated against canine TLR 4, 5 and 9 identify the expression of these TLRs in formalin-fixed canine lymph nodes and demonstrate increased expression in reactive canine mesenteric lymph nodes.	Formaldehyde	140-148	toll like receptor 4	Canis lupus familiaris	84-89
23024594-2	2012	The methylation status of 503 genes in 52 formalin-fixed paraffin-embedded EWS tumors and 3 EWS cell lines was compared to human mesenchymal stem cell primary cultures (hMSCs) using bead chip methylation analysis.	Formaldehyde	42-50	EWS RNA binding protein 1	Homo sapiens	75-78
21549695-11	2011	Furthermore, kappa-opioid receptor stimulation using U-50,488H, a kappa-opioid receptor agonist, or establishment of formalin-induced chronic pain can completely suppress these changes in protein expression levels of NCAM and PKC-alpha and inhibit development of analgesic tolerance to morphine.	Formaldehyde	117-125	protein kinase C, alpha	Mus musculus	226-235
22347464-0	2012	KLC1-ALK: a novel fusion in lung cancer identified using a formalin-fixed paraffin-embedded tissue only.	Formaldehyde	59-67	kinesin light chain 1	Mus musculus	0-4
22347464-0	2012	KLC1-ALK: a novel fusion in lung cancer identified using a formalin-fixed paraffin-embedded tissue only.	Formaldehyde	59-67	anaplastic lymphoma kinase	Mus musculus	5-8
22490213-9	2012	CONCLUSIONS: Activation of p38 mitogen-activated protein kinase played a major role in the development of orofacial inflammatory pain and it was verified by the experimental result that p38MAPK inhibitor SB203580 inhibited the formalin-induced orofacial pain.	Formaldehyde	227-235	mitogen activated protein kinase 14	Rattus norvegicus	27-63
22034943-9	2011	In parallel, in a cellular approach using the human monocytic THP-1 cell line, 2-bromo-2-nitropropane-1,3-diol activates THP-1 cells at concentrations that are not correlated to simple formaldehyde release.	Formaldehyde	185-197	GLI family zinc finger 2	Homo sapiens	62-67
21549695-11	2011	Furthermore, kappa-opioid receptor stimulation using U-50,488H, a kappa-opioid receptor agonist, or establishment of formalin-induced chronic pain can completely suppress these changes in protein expression levels of NCAM and PKC-alpha and inhibit development of analgesic tolerance to morphine.	Formaldehyde	117-125	neural cell adhesion molecule 1	Mus musculus	217-221
22095230-4	2011	Formalin-fixed, paraffin-embedded specimens from melanoma patients were used for immunocytochemical analysis of NF-kappaB activity in situ.	Formaldehyde	0-8	nuclear factor kappa B subunit 1	Homo sapiens	112-121
22153631-13	2011	Results of previous studies have likewise been variable, suggesting that immunohistochemical determination of IGF-1R from formalin-fixed, paraffin-embedded specimens is not practical as a routine test.	Formaldehyde	122-130	insulin like growth factor 1 receptor	Homo sapiens	110-116
22132735-3	2011	MATERIALS AND METHODS: EGFR gene amplification and mutations were investigated in formalin-fixed, paraffin-embedded tissues from 139 Chinese female patients with breast cancer by means of fluorescence in-situ hybridization (FISH) and fluorescently labeled real-time quantitative polymerase chain reaction (RT-PCR), respectively.	Formaldehyde	82-90	epidermal growth factor receptor	Homo sapiens	23-27
22393743-3	2011	Real time RT-PCR was used to investigate the influence of OSR on the expression of GAT-1 mRNA induced by formalin in spinal cord and brain of mice.	Formaldehyde	105-113	solute carrier family 6 (neurotransmitter transporter, GABA), member 1	Mus musculus	83-88
21721010-3	2011	Formalin-fixed paraffin-embedded specimens were stained for MMP-2 and MMP-9, which were statistically evaluated for their prognostic value and other clinicopathological parameters.	Formaldehyde	0-8	matrix metallopeptidase 2	Homo sapiens	60-65
22149278-7	2011	In addition, anti-MUC1-CD can be used to detect expression of the MUC1-C subunit in formalin-fixed, paraffin-embedded tissues.	Formaldehyde	84-92	mucin 1, cell surface associated	Homo sapiens	18-22
22149278-7	2011	In addition, anti-MUC1-CD can be used to detect expression of the MUC1-C subunit in formalin-fixed, paraffin-embedded tissues.	Formaldehyde	84-92	mucin 1, cell surface associated	Homo sapiens	66-70
22081130-6	2011	Two polymorphic loci of the APC gene were investigated for LOH and sequence analysis was performed for the mutation cluster region of the APC gene on formalin fixed, paraffin embedded samples.	Formaldehyde	150-158	APC regulator of WNT signaling pathway	Homo sapiens	138-141
22393743-5	2011	OSR (500.0 mg x kg(-1), iv) significantly inhibited the expression of GAT-1 mRNA induced by formalin (P &lt; 0.05).	Formaldehyde	92-100	solute carrier family 6 (neurotransmitter transporter, GABA), member 1	Mus musculus	70-75
21907259-2	2011	Microarray analyses and quantitative real-time PCR using human renal tubular cells showed that the mRNA expression of VNN-1 which encodes vanin-1, increased after the exposure of these cells to organic solvents (allyl alcohol, ethylene glycol, formaldehyde, chloroform, and phenol) for 24h.	Formaldehyde	244-256	vanin 1	Homo sapiens	118-123
21907259-2	2011	Microarray analyses and quantitative real-time PCR using human renal tubular cells showed that the mRNA expression of VNN-1 which encodes vanin-1, increased after the exposure of these cells to organic solvents (allyl alcohol, ethylene glycol, formaldehyde, chloroform, and phenol) for 24h.	Formaldehyde	244-256	vanin 1	Homo sapiens	138-145
22112588-5	2011	Both intraplantar and intrathecal (0.5 or 1 nmol/3 mul) injection of kisspeptin caused hyperalgesia in the first and second phases of the formalin test, whereas the GPR54 antagonist, p234 (0.1 or 1 nmol), caused a robust analgesia.	Formaldehyde	138-146	KiSS-1 metastasis-suppressor	Mus musculus	69-79
21889580-6	2011	DBV treatment reduced pain responses in the late phase of the formalin test and significantly blocked the formalin-evoked increase in spinal GFAP expression.	Formaldehyde	106-114	glial fibrillary acidic protein	Homo sapiens	141-145
22112588-6	2011	Intraplantar injection of kisspeptin combined with formalin enhanced TRPV1 phosphorylation at Ser800 at the injection site, and increased ERK1/2 phosphorylation in the ipsilateral dorsal horn as compared to naive mice and mice treated with formalin alone.	Formaldehyde	51-59	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	69-74
22112588-6	2011	Intraplantar injection of kisspeptin combined with formalin enhanced TRPV1 phosphorylation at Ser800 at the injection site, and increased ERK1/2 phosphorylation in the ipsilateral dorsal horn as compared to naive mice and mice treated with formalin alone.	Formaldehyde	51-59	mitogen-activated protein kinase 3	Mus musculus	138-144
22112588-6	2011	Intraplantar injection of kisspeptin combined with formalin enhanced TRPV1 phosphorylation at Ser800 at the injection site, and increased ERK1/2 phosphorylation in the ipsilateral dorsal horn as compared to naive mice and mice treated with formalin alone.	Formaldehyde	240-248	KiSS-1 metastasis-suppressor	Mus musculus	26-36
21942893-0	2011	Density functional theory study of the carbonyl-ene reaction of encapsulated formaldehyde in Cu(I), Ag(I), and Au(I) exchanged FAU zeolites.	Formaldehyde	77-89	FAU ubiquitin like and ribosomal protein S30 fusion	Homo sapiens	127-130
21942893-2	2011	The formaldehyde-propene reaction catalyzed by several of the group 11 metal cations, Cu(+), Ag(+), and Au(+) exchanged on the faujasite zeolite (metal-FAU) has been investigated by density functional theory at the M06-L/6-31G(d,p) level.	Formaldehyde	4-16	FAU ubiquitin like and ribosomal protein S30 fusion	Homo sapiens	152-155
22081012-2	2011	Here we report a synthetic lethal interaction in avian cells between ADH5, encoding the main formaldehyde-detoxifying enzyme, and the Fanconi anemia (FA) DNA-repair pathway.	Formaldehyde	93-105	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	69-73
22092403-3	2011	METHODS AND RESULTS: PR expression was examined by immunohistochemistry (n=143) and kinetic reverse transcription-polymerase chain reaction (RT-PCR) from formalin-fixed and paraffin-embedded tissue (n=55).	Formaldehyde	154-162	progesterone receptor	Homo sapiens	21-23
21921041-1	2011	We performed a comprehensive genome-wide miRNA expression profiling of extranodal nasal-type natural killer/T-cell lymphoma (NKTL) using formalin-fixed paraffin-embedded tissue (n = 30) and NK cell lines (n = 6) compared with normal NK cells, with the objective of understanding the pathogenetic role of miRNA deregulation in NKTL.	Formaldehyde	137-145	SCY1 like pseudokinase 1	Homo sapiens	125-129
21906649-3	2011	PspA was modified by reductive amination with formaldehyde in order to improve the specificity of the reaction between protein and polysaccharide, inhibiting polymerization and the gel formation reaction.	Formaldehyde	46-58	surfactant associated protein A1	Mus musculus	0-4
21495021-5	2011	Among the enriched pathways, vascular endothelial growth factor (VEGF) pathway genes collectively were amplified, and alterations of this pathway were validated by fluorescence in situ hybridization (FISH) and immunohistochemistry analyses in 58 formalin-fixed, paraffin-embedded osteosarcoma archival tissues that had clinical follow-up information.	Formaldehyde	246-254	vascular endothelial growth factor A	Homo sapiens	29-63
21495021-5	2011	Among the enriched pathways, vascular endothelial growth factor (VEGF) pathway genes collectively were amplified, and alterations of this pathway were validated by fluorescence in situ hybridization (FISH) and immunohistochemistry analyses in 58 formalin-fixed, paraffin-embedded osteosarcoma archival tissues that had clinical follow-up information.	Formaldehyde	246-254	vascular endothelial growth factor A	Homo sapiens	65-69
21699410-9	2011	KRAS mutation screening on formalin-fixed, paraffin-embedded DNA is very efficient with real-time PCR methods in comparison to direct sequencing.	Formaldehyde	27-35	KRAS proto-oncogene, GTPase	Homo sapiens	0-4
22083191-0	2011	[High-throughput screening method of KRAS mutations at codons 12 and 13 in formalin-fixed paraffin-embedded tissue specimens of metastatic colorectal cancer].	Formaldehyde	75-83	KRAS proto-oncogene, GTPase	Homo sapiens	37-41
22054645-8	2011	Finally, inhibition of PKCzeta/PKMzeta activity decreased the expression of Fos in response to formalin and CFA in both superficial and deep laminae of the dorsal horn.	Formaldehyde	95-103	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	76-79
21519917-3	2011	METHODS: Expression of CAIX and Her-2 was investigated immunohistochemically in formalin fixed, paraffin-embedded tissue from 330 esophageal cancers (182 ACS, 148 SCCs).	Formaldehyde	80-88	carbonic anhydrase 9	Homo sapiens	23-27
21533822-3	2011	METHODS: GCC mRNA was quantified by RT-qPCR using formalin-fixed LN tissues from patients with untreated stage II colon cancer who were diagnosed from 1999-2006 with at least ten LNs examined and blinded to clinical outcomes.	Formaldehyde	50-58	guanylate cyclase 2C	Homo sapiens	9-12
21873495-1	2011	In Gram-negative methylotrophic bacteria, the first step in methylotrophic growth is the oxidation of methanol to formaldehyde in the periplasm by methanol dehydrogenase.	Formaldehyde	114-126	MEXAM1_RS21720	Methylobacterium extorquens AM1	156-169
21839586-2	2011	An example of this may be the increased susceptibility of BRCA1 or BRCA2 mutation carriers to the carcinogen formaldehyde.	Formaldehyde	109-121	BRCA1 DNA repair associated	Homo sapiens	58-63
21839586-2	2011	An example of this may be the increased susceptibility of BRCA1 or BRCA2 mutation carriers to the carcinogen formaldehyde.	Formaldehyde	109-121	BRCA2 DNA repair associated	Homo sapiens	67-72
21839586-6	2011	It is known that some types of formaldehyde-associated DNA damage require error-free DNA repairs mediated by pathways containing BRCA1 and BRCA2 proteins.	Formaldehyde	31-43	BRCA1 DNA repair associated	Homo sapiens	129-134
21958527-3	2011	TEM-7 expression was assessed by in situ hybridization or by immunohistochemistry (IHC) in 130 formalin-fixed paraffin-embedded (FFPE) and 410 frozen human clinical specimens of cancer plus 301 normal tissue samples.	Formaldehyde	95-103	plexin domain containing 1	Homo sapiens	0-5
21839586-6	2011	It is known that some types of formaldehyde-associated DNA damage require error-free DNA repairs mediated by pathways containing BRCA1 and BRCA2 proteins.	Formaldehyde	31-43	BRCA2 DNA repair associated	Homo sapiens	139-144
21839586-11	2011	BRCA1/2 mutation carriers may reduce risks for myeloid leukemias by using available precautions to lower their exposure to formaldehyde.	Formaldehyde	123-135	BRCA1 DNA repair associated	Homo sapiens	0-5
21864979-6	2011	URB597 (inhibitor of fatty acid amide hydrolase [FAAH]), administered bilaterally into the vHip, significantly enhanced FCA during the entire trial and increased fear responding in formalin-treated rats early in the trial.	Formaldehyde	181-189	fatty-acid amide hydrolase-like	Rattus norvegicus	49-53
22019732-1	2011	Quantitative trait locus mapping of chemical/inflammatory pain in the mouse identified the Avpr1a gene, which encodes the vasopressin-1A receptor (V1AR), as being responsible for strain-dependent pain sensitivity to formalin and capsaicin.	Formaldehyde	216-224	arginine vasopressin receptor 1A	Mus musculus	91-97
21683728-7	2011	Formalin-evoked nociceptive behaviour in non-fear-conditioned rats was associated with increased field potential amplitude in the dPAG and increased relative expression of phospho-ERK in the PFC.	Formaldehyde	0-8	Eph receptor B1	Rattus norvegicus	180-183
21683728-9	2011	Fear conditioning in non-formalin treated rats was associated with increased phospho-ERK in the PFC but no change in field potential amplitude in the dPAG.	Formaldehyde	25-33	Eph receptor B1	Rattus norvegicus	85-88
21903328-8	2011	The reduction was accompanied by a decrease in formalin-induced expression of spinal c-Fos protein that serves as an index of spinal nociceptive processing.	Formaldehyde	47-55	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	85-90
21872983-1	2011	A combined reaction, consisting of granular activated carbon (GAC) adsorption and catalytic oxidation, has been proposed to improve the removal efficiencies of formaldehyde, one of the major indoor air pollutants.	Formaldehyde	160-172	glutaminase	Homo sapiens	62-65
21872983-2	2011	In this study, silver nano-particles attached onto the surface of GAC (Ag-GAC) using the sputtering method were evaluated for the simultaneous catalytic oxidation and adsorption of formaldehyde.	Formaldehyde	181-193	glutaminase	Homo sapiens	66-69
21872983-2	2011	In this study, silver nano-particles attached onto the surface of GAC (Ag-GAC) using the sputtering method were evaluated for the simultaneous catalytic oxidation and adsorption of formaldehyde.	Formaldehyde	181-193	glutaminase	Homo sapiens	71-77
21872983-4	2011	In addition, a packed column test showed that the mass of formaldehyde removed by the Ag-GAC was 2.4 times higher than that by the virgin GAC at a gas retention time of 0.5s.	Formaldehyde	58-70	glutaminase	Homo sapiens	86-92
21872983-4	2011	In addition, a packed column test showed that the mass of formaldehyde removed by the Ag-GAC was 2.4 times higher than that by the virgin GAC at a gas retention time of 0.5s.	Formaldehyde	58-70	glutaminase	Homo sapiens	89-92
21872983-8	2011	The model predictions implied that the silver nano-particles deposited on the GAC reduced the adsorptive capacity due to decreasing the available surface for the diffusion of formaldehyde into the GAC, but the overall mass of formaldehyde removed by the Ag-GAC was increased due to catalytic oxidation as a function of the ratio of the surface coverage by the nano-particles.	Formaldehyde	175-187	glutaminase	Homo sapiens	78-81
21872983-8	2011	The model predictions implied that the silver nano-particles deposited on the GAC reduced the adsorptive capacity due to decreasing the available surface for the diffusion of formaldehyde into the GAC, but the overall mass of formaldehyde removed by the Ag-GAC was increased due to catalytic oxidation as a function of the ratio of the surface coverage by the nano-particles.	Formaldehyde	175-187	glutaminase	Homo sapiens	197-200
21872983-8	2011	The model predictions implied that the silver nano-particles deposited on the GAC reduced the adsorptive capacity due to decreasing the available surface for the diffusion of formaldehyde into the GAC, but the overall mass of formaldehyde removed by the Ag-GAC was increased due to catalytic oxidation as a function of the ratio of the surface coverage by the nano-particles.	Formaldehyde	226-238	glutaminase	Homo sapiens	78-81
21872983-8	2011	The model predictions implied that the silver nano-particles deposited on the GAC reduced the adsorptive capacity due to decreasing the available surface for the diffusion of formaldehyde into the GAC, but the overall mass of formaldehyde removed by the Ag-GAC was increased due to catalytic oxidation as a function of the ratio of the surface coverage by the nano-particles.	Formaldehyde	226-238	glutaminase	Homo sapiens	254-260
22032294-4	2011	METHODS: Taking advantage of MEM-E/02, a recently characterized antibody to denatured HLA-E molecules, HLA-E expression was assessed by immunohistochemistry on an archival collection (formalin-fixed paraffin-embedded) of 149 colorectal primary carcinoma lesions paired with their morphologically normal mucosae.	Formaldehyde	184-192	major histocompatibility complex, class I, E	Homo sapiens	103-108
22019732-1	2011	Quantitative trait locus mapping of chemical/inflammatory pain in the mouse identified the Avpr1a gene, which encodes the vasopressin-1A receptor (V1AR), as being responsible for strain-dependent pain sensitivity to formalin and capsaicin.	Formaldehyde	216-224	arginine vasopressin receptor 1A	Mus musculus	122-145
22019732-1	2011	Quantitative trait locus mapping of chemical/inflammatory pain in the mouse identified the Avpr1a gene, which encodes the vasopressin-1A receptor (V1AR), as being responsible for strain-dependent pain sensitivity to formalin and capsaicin.	Formaldehyde	216-224	arginine vasopressin receptor 1A	Mus musculus	147-151
21854218-0	2011	Adjuvant effects of gaseous formaldehyde on the hyper-responsiveness and inflammation in a mouse asthma model immunized by ovalbumin.	Formaldehyde	28-40	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	123-132
21878536-4	2011	EXPERIMENTAL DESIGN: PTEN IHC was validated by employing formalin fixed and paraffin-embedded isogenic human cell lines containing or lacking intact PTEN alleles.	Formaldehyde	57-65	phosphatase and tensin homolog	Homo sapiens	21-25
21841815-8	2011	Treatment with the alpha7-nAChR agonist PNU282987 (3 mg/kg) significantly reduced the formalin-induced phase 2 pain response, but only slightly reduced the Phase 1 pain response.	Formaldehyde	86-94	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	26-31
21841815-9	2011	CONCLUSION: The results suggest that CTX exerts an antinociceptive effect in formalin-induced inflammatory pain, which appears to be mediated by mAChR and alpha7-nAChR.	Formaldehyde	77-85	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	162-167
21756895-6	2011	Another nicotinic acetylcholine receptor agonist, 5-[(1R,5S)-3,6-Diazabicyclo[3.2.0]heptan-6-yl]nicotinonitrile (A-366833) from the same group produced significant antinociceptive effects in writhing pain (abdominal constriction), acute thermal pain (hot box), persistent chemical pain (formalin induced) and neuropathic pain.	Formaldehyde	287-295	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	8-40
21427709-4	2011	Here, we show that spinal delivery of the mimetic peptide Tat-NR2B9c disrupts the interaction between PSD-95 and NR2B subunits in the dorsal horn and selectively reduces NMDA receptor-dependent events including wind-up of spinal sensory neurons, and both persistent formalin-induced neuronal activity and pain-related behaviors, attributed to central sensitization.	Formaldehyde	266-274	discs large MAGUK scaffold protein 4	Homo sapiens	102-108
21427709-4	2011	Here, we show that spinal delivery of the mimetic peptide Tat-NR2B9c disrupts the interaction between PSD-95 and NR2B subunits in the dorsal horn and selectively reduces NMDA receptor-dependent events including wind-up of spinal sensory neurons, and both persistent formalin-induced neuronal activity and pain-related behaviors, attributed to central sensitization.	Formaldehyde	266-274	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	62-66
21572321-9	2011	To conclude, mRNA expression levels of molecular markers in formalin-fixed paraffin-embedded specimens of primary gastric tumors can be useful for identifying patients with advanced gastric cancer who would most likely benefit from S-1 treatment.	Formaldehyde	60-68	proteasome 26S subunit, non-ATPase 1	Homo sapiens	232-235
22321542-2	2011	METHODS: Optimized oligonucleotide probe method was applied to detect EGFR mutations involving exons 18 - 21 using formalin fixed paraffin embedded tissue specimens of 309 NSCLC patients.	Formaldehyde	115-123	epidermal growth factor receptor	Homo sapiens	70-74
21761570-0	2011	Kinetics studies of the enantioselective hydroxymethylation of silicon enolates using aqueous formaldehyde in the presence of Sc(OTf)3 and a chiral 2,2"-bipyridine ligand.	Formaldehyde	94-106	POU class 5 homeobox 1	Homo sapiens	126-134
21917790-6	2011	Using preprotachykinin A knock-out mice, we first confirmed that substance P partly mediates intraplantar formalin- and capsaicin-induced pain behaviors.	Formaldehyde	106-114	tachykinin 1	Mus musculus	65-76
21917790-9	2011	We found that both agonists were able to decrease formalin- and capsaicin-induced pain, an effect that was correlated with a reduction in the number of c-fos-positive neurons in the superficial laminae of the lumbar spinal cord.	Formaldehyde	50-58	FBJ osteosarcoma oncogene	Mus musculus	152-157
21917790-10	2011	Finally, visualization of NK(1) (neurokinin 1) receptor internalization revealed that DOPR and MOPR activation strongly reduced formalin- and capsaicin-induced substance P release via direct action on primary afferent fibers.	Formaldehyde	128-136	tachykinin 1	Mus musculus	26-31
21917790-10	2011	Finally, visualization of NK(1) (neurokinin 1) receptor internalization revealed that DOPR and MOPR activation strongly reduced formalin- and capsaicin-induced substance P release via direct action on primary afferent fibers.	Formaldehyde	128-136	tachykinin 1	Mus musculus	33-45
21917790-10	2011	Finally, visualization of NK(1) (neurokinin 1) receptor internalization revealed that DOPR and MOPR activation strongly reduced formalin- and capsaicin-induced substance P release via direct action on primary afferent fibers.	Formaldehyde	128-136	opioid receptor, mu 1	Mus musculus	95-99
21917790-10	2011	Finally, visualization of NK(1) (neurokinin 1) receptor internalization revealed that DOPR and MOPR activation strongly reduced formalin- and capsaicin-induced substance P release via direct action on primary afferent fibers.	Formaldehyde	128-136	tachykinin 1	Mus musculus	160-171
21289364-2	2011	PATIENTS AND METHODS: Using a novel assay, HER2 protein expression (H2T) was measured in formalin-fixed, paraffin-embedded primary breast tumors from 98 women treated with trastuzumab-based therapy for MBC.	Formaldehyde	89-97	erb-b2 receptor tyrosine kinase 2	Homo sapiens	43-47
22235214-4	2011	PATIENTS AND METHODS: The methylation pattern in the p16 gene promoter was analyzed by bisulfite direct sequencing in 43 paraffin-embedded formalin-fixed tissues from patients with HCC.	Formaldehyde	139-147	cyclin dependent kinase inhibitor 2A	Homo sapiens	53-56
21597362-0	2011	Activation of metabotropic glutamate receptor 7 in spinal cord inhibits pain and hyperalgesia in a novel formalin model in sheep.	Formaldehyde	105-113	metabotropic glutamate receptor 7	Ovis aries	14-47
21597362-1	2011	This study set out to characterize the contribution of group III metabotropic glutamate receptor 7 activation to nociceptive behaviour and mechanical hypersensitivity in a novel formalin test in sheep.	Formaldehyde	178-186	metabotropic glutamate receptor 7	Ovis aries	65-98
21273385-3	2011	Mice were exposed intranasally to formalin-killed Mycobacterium avium from a patient with hot tub lung (HP strain) or chronic pulmonary infection (non-HP strain), and bronchoalveolar lavage fluids and lung tissues were evaluated for allergic inflammation.	Formaldehyde	34-42	TUB bipartite transcription factor	Homo sapiens	94-97
20945089-8	2011	Upregulation of HOXB13 was seen in malignant relative to borderline phyllodes tumors and further investigated by immunohistochemistry in a corresponding set of formalin-fixed, paraffin-embedded tumors.	Formaldehyde	160-168	homeobox B13	Homo sapiens	16-22
21640373-2	2011	METHODS: We designed and optimized a matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF-MS) genotyping assay to detect FOXL2 C402G mutation in DNA isolated from formalin-fixed paraffin-embedded tissue samples.	Formaldehyde	198-206	forkhead box L2	Homo sapiens	156-161
21763398-4	2011	Intrathecal administration of the partially selective NHE1 inhibitors DMA, EIPA (0.3-30muM/rat) and the selective NHE1 inhibitor zoniporide (0.03-3muM/rat) significantly increased formalin-induced flinching behavior in a dose-dependent manner during both phases of the test.	Formaldehyde	180-188	solute carrier family 9 member A1	Rattus norvegicus	54-58
21813779-6	2011	IKKepsilon mRNA and protein levels rapidly increased in spinal cord and dorsal root ganglia during hind paw inflammation evoked by injection of zymosan or formalin.	Formaldehyde	155-163	inhibitor of kappaB kinase epsilon	Mus musculus	0-10
21406308-0	2011	Coamplification at lower denaturation temperature polymerase chain reaction enables selective identification of K-Ras mutations in formalin-fixed, paraffin-embedded tumor tissues without tumor-cell enrichment.	Formaldehyde	131-139	KRAS proto-oncogene, GTPase	Homo sapiens	112-117
21406308-3	2011	We applied the recently described coamplification at lower denaturation temperature polymerase chain reaction, which amplifies minority alleles selectively, to detect K-Ras mutations directly in 29 formalin-fixed, paraffin-embedded pancreatic specimens and compared the results with those of conventional polymerase chain reaction.	Formaldehyde	198-206	KRAS proto-oncogene, GTPase	Homo sapiens	167-172
21406308-9	2011	The technique is a good strategy to detect K-Ras mutations selectively in formalin-fixed, paraffin-embedded tissues without tumor-cell enrichment.	Formaldehyde	74-82	KRAS proto-oncogene, GTPase	Homo sapiens	43-48
22276430-7	2011	Moreover, both the point gsh1 and null gsh1/met1 mutants displayed increased sensitivity to the toxic carbon substrate methanol, formaldehyde, organic peroxide and cadmium ions.	Formaldehyde	129-141	glutamate--cysteine ligase	Saccharomyces cerevisiae S288C	25-29
22276430-7	2011	Moreover, both the point gsh1 and null gsh1/met1 mutants displayed increased sensitivity to the toxic carbon substrate methanol, formaldehyde, organic peroxide and cadmium ions.	Formaldehyde	129-141	glutamate--cysteine ligase	Saccharomyces cerevisiae S288C	39-43
22276430-7	2011	Moreover, both the point gsh1 and null gsh1/met1 mutants displayed increased sensitivity to the toxic carbon substrate methanol, formaldehyde, organic peroxide and cadmium ions.	Formaldehyde	129-141	uroporphyrinogen-III C-methyltransferase	Saccharomyces cerevisiae S288C	44-48
21700387-9	2011	We observed complete reduction of DNAN to 2,4-diaminoanisole (DAAN) and RDX to formaldehyde in abiotic iron reduction study.	Formaldehyde	79-91	radixin	Homo sapiens	72-75
21763398-4	2011	Intrathecal administration of the partially selective NHE1 inhibitors DMA, EIPA (0.3-30muM/rat) and the selective NHE1 inhibitor zoniporide (0.03-3muM/rat) significantly increased formalin-induced flinching behavior in a dose-dependent manner during both phases of the test.	Formaldehyde	180-188	solute carrier family 9 member A1	Rattus norvegicus	114-118
21763398-7	2011	Collectively, these pharmacological and anatomical results suggest that spinal NHE1 plays a role in formalin-induced nociception acting as a protective protein extruding H(+).	Formaldehyde	100-108	solute carrier family 9 member A1	Rattus norvegicus	79-83
21843375-4	2011	PrPC null mice also exhibited significantly longer licking/biting time during both the first and second phases of formalin-induced inflammation of the paw, which was again prevented by treatment of the mice with MK-801, and responded more strongly to glutamate injection into the paw.	Formaldehyde	114-122	prion protein	Mus musculus	0-4
21516079-3	2011	We report our experience of routine KRAS/BRAF mutation screening practice performed on 1130 formalin-fixed paraffin-embedded tumor samples from 992 colorectal cancer patients.	Formaldehyde	92-100	KRAS proto-oncogene, GTPase	Homo sapiens	36-40
21410769-2	2011	The purpose of this study was to compare the expression of apoptosis-inducing factor (AIF), a major effector of the caspase-independent apoptosis pathway, in formalin-fixed SCC (N = 23) and KA (N = 29) resection specimens.	Formaldehyde	158-166	apoptosis inducing factor mitochondria associated 1	Homo sapiens	59-84
21410769-2	2011	The purpose of this study was to compare the expression of apoptosis-inducing factor (AIF), a major effector of the caspase-independent apoptosis pathway, in formalin-fixed SCC (N = 23) and KA (N = 29) resection specimens.	Formaldehyde	158-166	apoptosis inducing factor mitochondria associated 1	Homo sapiens	86-89
21410769-2	2011	The purpose of this study was to compare the expression of apoptosis-inducing factor (AIF), a major effector of the caspase-independent apoptosis pathway, in formalin-fixed SCC (N = 23) and KA (N = 29) resection specimens.	Formaldehyde	158-166	serpin family B member 3	Homo sapiens	173-176
21447517-6	2011	The presence of intracytoplasmic C-reactive protein was assessed in formalin-fixed atrial specimens by immunohistochemistry.	Formaldehyde	68-76	C-reactive protein	Homo sapiens	33-51
20874717-6	2011	Formalin-fixed mid-ventricle tissue sections stained with picrosirius red, haematoxylin and eosin and toluidine blue dyes exhibited a 150% decrease in collagen deposition, a two-fold decrease in inflammation and a 30% reduction in mast cell degranulation, respectively, in rat hearts treated with the selective PKCbetaII inhibitor.	Formaldehyde	0-8	phospholipase C, beta 2	Rattus norvegicus	311-320
21741330-4	2011	We used samples obtained from differently fragmented crude tetanus toxins by formaldehyde treatment (assigned as TTd-A and TTd-B) as starting material for tetanus toxoid purification.	Formaldehyde	77-89	general transcription factor IIH subunit 5	Homo sapiens	113-118
21181234-4	2011	We have developed a primer extension-based assay adapted to formalin-fixed paraffin-embedded tissues that enables quantitative assessment of the methylation status of the MGMT promoter.	Formaldehyde	60-68	O-6-methylguanine-DNA methyltransferase	Homo sapiens	171-175
21198549-12	2011	CONCLUSIONS AND IMPLICATIONS MGL inhibitors suppressed formalin-induced pain through peripheral CB(1) and CB(2) receptor mechanisms.	Formaldehyde	55-63	monoglyceride lipase	Rattus norvegicus	29-32
21198549-12	2011	CONCLUSIONS AND IMPLICATIONS MGL inhibitors suppressed formalin-induced pain through peripheral CB(1) and CB(2) receptor mechanisms.	Formaldehyde	55-63	cannabinoid receptor 2	Rattus norvegicus	106-120
21693655-3	2011	PATIENTS AND METHODS: Epithelial p53 expression was evaluated using two immunohistochemical antibodies (DO7 and 1801) in formalin-fixed, paraffin-embedded tissue from patients with node-positive breast cancer who were randomized to four cycles of cyclophosphamide and one of three doses of doxorubicin (60, 75, or 90 mg/m(2); AC) and to receive four subsequent cycles of paclitaxel (T) or not.	Formaldehyde	121-129	tumor protein p53	Homo sapiens	33-36
21414430-6	2011	The metabolites of BZA or MA catalyzed by SSAO, hydrogen peroxide, formaldehyde, and benzaldehyde could also significantly decrease LPS-induced nitric oxide and TNF-alpha production, iNOS and COX-2 expression, and glucose consumption in vitro.	Formaldehyde	67-79	tumor necrosis factor	Mus musculus	161-170
21414430-6	2011	The metabolites of BZA or MA catalyzed by SSAO, hydrogen peroxide, formaldehyde, and benzaldehyde could also significantly decrease LPS-induced nitric oxide and TNF-alpha production, iNOS and COX-2 expression, and glucose consumption in vitro.	Formaldehyde	67-79	nitric oxide synthase 2, inducible	Mus musculus	183-187
21414430-6	2011	The metabolites of BZA or MA catalyzed by SSAO, hydrogen peroxide, formaldehyde, and benzaldehyde could also significantly decrease LPS-induced nitric oxide and TNF-alpha production, iNOS and COX-2 expression, and glucose consumption in vitro.	Formaldehyde	67-79	cytochrome c oxidase II, mitochondrial	Mus musculus	192-197
21495034-3	2011	Formalin-fixed paraffin-embedded specimens were stained for nm23-H1 and PCNA, the correlation between the staining and its clinicopathological parameters, and its prognostic power were analyzed statistically.	Formaldehyde	0-8	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	60-67
21495034-3	2011	Formalin-fixed paraffin-embedded specimens were stained for nm23-H1 and PCNA, the correlation between the staining and its clinicopathological parameters, and its prognostic power were analyzed statistically.	Formaldehyde	0-8	proliferating cell nuclear antigen	Homo sapiens	72-76
21516079-3	2011	We report our experience of routine KRAS/BRAF mutation screening practice performed on 1130 formalin-fixed paraffin-embedded tumor samples from 992 colorectal cancer patients.	Formaldehyde	92-100	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	41-45
21516079-11	2011	Routine KRAS genotyping performed on formalin-fixed paraffin-embedded tissues requires, therefore, the development of quality control scheme for molecular pathology, especially because of DNA damages induced by formalin fixation.	Formaldehyde	37-45	KRAS proto-oncogene, GTPase	Homo sapiens	8-12
21516079-11	2011	Routine KRAS genotyping performed on formalin-fixed paraffin-embedded tissues requires, therefore, the development of quality control scheme for molecular pathology, especially because of DNA damages induced by formalin fixation.	Formaldehyde	211-219	KRAS proto-oncogene, GTPase	Homo sapiens	8-12
21557612-4	2011	Moreover, the CdS/ZnO materials exhibit a dramatic improvement in optoelectronic performance and visible-light-irradiation gas sensing activity, which gave 1 order of magnitude larger than that of CdS NWs in response to formaldehyde.	Formaldehyde	220-232	CDP-diacylglycerol synthase 1	Homo sapiens	14-17
21756313-4	2011	RESULTS: In a model of tissue injury-induced pain, evoked by intraplantar injection of formalin, both iNOS-/-and n/i/eNOS-/-mice exhibited attenuations of pain behaviors in the second phase compared with that in wild-type mice.	Formaldehyde	87-95	nitric oxide synthase 2, inducible	Mus musculus	102-106
21756313-4	2011	RESULTS: In a model of tissue injury-induced pain, evoked by intraplantar injection of formalin, both iNOS-/-and n/i/eNOS-/-mice exhibited attenuations of pain behaviors in the second phase compared with that in wild-type mice.	Formaldehyde	87-95	nitric oxide synthase 3, endothelial cell	Mus musculus	117-121
21634377-0	2011	Identification of a potent, state-dependent inhibitor of Nav1.7 with oral efficacy in the formalin model of persistent pain.	Formaldehyde	90-98	sodium voltage-gated channel alpha subunit 9	Rattus norvegicus	57-63
21557612-4	2011	Moreover, the CdS/ZnO materials exhibit a dramatic improvement in optoelectronic performance and visible-light-irradiation gas sensing activity, which gave 1 order of magnitude larger than that of CdS NWs in response to formaldehyde.	Formaldehyde	220-232	CDP-diacylglycerol synthase 1	Homo sapiens	197-200
21708075-9	2011	The licking time induced by 0.1% formalin was significantly shortened in the CPN+TN-ligated group and significantly prolonged in the SN-ligated group.	Formaldehyde	33-41	carboxypeptidase N, polypeptide 1	Mus musculus	77-83
21638088-4	2011	Here we describe the development of a monoclonal BRAF V600E mutation-specific antibody that can differentiate BRAF V600E and wild type protein in routinely processed formalin-fixed and paraffin-embedded tissue.	Formaldehyde	166-174	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	49-53
21638088-4	2011	Here we describe the development of a monoclonal BRAF V600E mutation-specific antibody that can differentiate BRAF V600E and wild type protein in routinely processed formalin-fixed and paraffin-embedded tissue.	Formaldehyde	166-174	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	110-114
21329384-0	2011	Multiple reaction monitoring assay for pre-eclampsia related calcyclin peptides in formalin fixed paraffin embedded placenta.	Formaldehyde	83-91	S100 calcium binding protein A6	Homo sapiens	61-70
21444354-8	2011	In our study, levels of SOD and CAT were significantly decreased, and GSH-Px, XO, MDA levels were significantly increased in rats treated with formaldehyde compared with those of the controls.	Formaldehyde	143-155	glutathione peroxidase 1	Rattus norvegicus	70-76
22037080-2	2011	MATERIALS AND METHODS: Immunohistochemical staining for Her-2/neu was performed on 10% formalin-fixed, paraffin-embedded primary carcinoma of the breast from 83 patients, between 2003 and 2007 using anti-Her-2/neu rabbit polyclonal antibody (DakoCytomation, CA, USA) and reactivity detected by an avidin-biotin immunoperoxidase method.	Formaldehyde	87-95	erb-b2 receptor tyrosine kinase 2	Homo sapiens	56-65
21444354-9	2011	Whereas, it was seen that there was an increase in SOD and CAT enzyme activities and decrease in MDA, XO, and GSH-Px levels in rats administered to omega-3 fatty acids with exposure of formaldehyde.	Formaldehyde	185-197	glutathione peroxidase 1	Rattus norvegicus	110-116
21377511-6	2011	As previously described, ERbeta KO females showed lower nociceptive responses compared to WT female mice during the interphase and early tonic phase 2 of the formalin test.	Formaldehyde	158-166	estrogen receptor 2 (beta)	Mus musculus	25-31
21377511-8	2011	Moreover, we found that ERalpha KO male and female mice presented a small increase in nociceptive behaviors during phase 1 of the formalin test, suggesting an anti-nociceptive effect of ERalpha.	Formaldehyde	130-138	estrogen receptor 1 (alpha)	Mus musculus	24-31
21642979-3	2011	A peptide of CRMP-2 fused to the HIV transactivator of transcription (TAT) protein (TAT-CBD3) decreased neuropeptide release from sensory neurons and excitatory synaptic transmission in dorsal horn neurons, reduced meningeal blood flow, reduced nocifensive behavior induced by formalin injection or corneal capsaicin application and reversed neuropathic hypersensitivity produced by an antiretroviral drug.	Formaldehyde	277-285	dihydropyrimidinase like 2	Homo sapiens	13-19
21463663-3	2011	Thirty minutes after APS, induced by a formalin injection into the left hind paw, PVN, BSTov, CeA and npEW all showed a peak in cFos mRNA expression that was followed by a robust increase in cFos protein-immunoreactivity, indicating a rapid increase in (immediate early) gene expression in all four brain nuclei.	Formaldehyde	39-47	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	128-132
21463663-3	2011	Thirty minutes after APS, induced by a formalin injection into the left hind paw, PVN, BSTov, CeA and npEW all showed a peak in cFos mRNA expression that was followed by a robust increase in cFos protein-immunoreactivity, indicating a rapid increase in (immediate early) gene expression in all four brain nuclei.	Formaldehyde	39-47	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	191-195
21491029-2	2011	Here a novel application of DESI-MS was demonstrated for direct probing of the reactive intermediates in the liquid-phase Eschweiler-Clarke reaction, a reductive amination reaction whereby a primary (or secondary) amine is successively N-methylated using excess formaldehyde and formic acid.	Formaldehyde	262-274	desumoylating isopeptidase 2	Homo sapiens	28-32
21491029-5	2011	The feasibility of the reactive DESI-MS detection of acid-formaldehyde methylations was further validated using amines of a large variety of chemical types (2 primary and 3 secondary amines).	Formaldehyde	58-70	desumoylating isopeptidase 2	Homo sapiens	32-36
21673449-0	2011	Interaction of histamine and calcitonin gene-related peptide in the formalin induced pain perception in rats.	Formaldehyde	68-76	calcitonin-related polypeptide alpha	Rattus norvegicus	29-60
21493867-6	2011	Evi-1 protein expression could be confirmed in formalin-fixed, paraffin-embedded samples of 26 of 28 infratentorial ependymomas but only in 7 of 47 nonependymal glial tumors (P &lt; 0.001).	Formaldehyde	47-55	MDS1 and EVI1 complex locus	Homo sapiens	0-5
21262917-5	2011	EXPERIMENTAL DESIGN: p14(ARF), p15(INK4b), and p16(INK4a) protein expressions were assessed by immunohistochemistry in 129 formalin-fixed samples of MPNST including 85 primary tumors.	Formaldehyde	123-131	cyclin dependent kinase inhibitor 2A	Homo sapiens	21-24
21510664-3	2011	The first enzyme to show such activity was LSD1, a flavin-containing enzyme that removes the methyl groups from lysines 4 and 9 of histone 3 with the generation of formaldehyde from the methyl group.	Formaldehyde	164-176	lysine demethylase 1A	Homo sapiens	43-47
21354147-4	2011	METHODS: We used immunohistochemical analyses to examine the expression of mPGES-1 in formalin-fixed, paraffin-embedded human cholangiocarcinoma tissues.	Formaldehyde	86-94	prostaglandin E synthase	Mus musculus	75-82
21345667-5	2011	METHODS: We performed immunohistochemical analyses on formalin-fixed paraffin embedded (FFPE) cancer tissue with an antibody against the Dicer protein.	Formaldehyde	54-62	dicer 1, ribonuclease III	Homo sapiens	137-142
21459678-6	2011	These intra-BLA muscimol-induced increases in c-Fos expression were abolished in rats receiving intraplantar formalin injection.	Formaldehyde	109-117	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	46-51
21705643-2	2011	To shed light on this issue, we used chromatin immunoprecipitation and formaldehyde-assisted isolation of regulatory elements to investigate the chromatin structure at target genes of HSF1 and CRR1, key transcriptional regulators of the heat shock and copper starvation responses, respectively, in the unicellular green alga Chlamydomonas reinhardtii.	Formaldehyde	71-83	uncharacterized protein	Chlamydomonas reinhardtii	184-188
21705643-2	2011	To shed light on this issue, we used chromatin immunoprecipitation and formaldehyde-assisted isolation of regulatory elements to investigate the chromatin structure at target genes of HSF1 and CRR1, key transcriptional regulators of the heat shock and copper starvation responses, respectively, in the unicellular green alga Chlamydomonas reinhardtii.	Formaldehyde	71-83	uncharacterized protein	Chlamydomonas reinhardtii	193-197
24278557-6	2011	DHU001 has favorable effects on formalin-induced chronic inflammation mediated by TNF-alpha suppression, and DHU001 may represent an alternative approach for the treatment of chronic inflammatory diseases.	Formaldehyde	32-40	tumor necrosis factor	Mus musculus	82-91
21510664-4	2011	This reaction is similar to the previously described demethylation reactions conducted by the enzymes dimethylglycine dehydrogenase and sarcosine dehydrogenase, in which protein-bound tetrahydrofolate serves as an accepter of the formaldehyde that is generated.	Formaldehyde	230-242	sarcosine dehydrogenase	Homo sapiens	118-159
21558128-5	2011	Possible causes of death are also discussed and a novel immunohistochemical method of demonstrating dystrophin deficiency using formalin-fixed tissue is described.	Formaldehyde	128-136	dystrophin	Homo sapiens	100-110
21559464-5	2011	A single percutaneous IT injection of BoNT-B 0.5 U at 2 or 5 days prior to IPLT formalin reduced NK1-R internalization and C-Fos expression.	Formaldehyde	80-88	tachykinin receptor 1	Rattus norvegicus	97-102
21488175-9	2011	In conclusion, IHC for Her2/neu, ER and PR performed on formalin-fixed, paraffin-embedded cell blocks prepared from fresh FNA and serous fluid is reliable in predicting the expression of these markers when correlated with IHC and FISH performed on the corresponding tumor tissue.	Formaldehyde	56-64	erb-b2 receptor tyrosine kinase 2	Homo sapiens	23-31
21251039-3	2011	METHODS: A commercially available antibody to CK15 was used on formalin-fixed, paraffin-embedded tissue from clinically and histologically "normal" scalps, clinically diseased scalps from patients with CCCA and clinically "normal" scalps from patients with CCCA.	Formaldehyde	63-71	keratin 15	Homo sapiens	46-50
21334366-9	2011	In addition, data suggest that spinal dynorphin A1-17 and CCK play an important role in formalin-induced secondary allodynia and hyperalgesia.	Formaldehyde	88-96	cholecystokinin	Rattus norvegicus	58-61
21972530-0	2011	[Effects of overexpression of heat shock protein 70 on the damage induced by formaldehyde in vitro].	Formaldehyde	77-89	heat shock protein family A (Hsp70) member 4	Homo sapiens	30-51
21972530-1	2011	OBJECTIVE: To investigate the protective role of inducible heat shock protein 70 (Hsp70) against damage induced by formaldehyde.	Formaldehyde	115-127	heat shock protein family A (Hsp70) member 4	Homo sapiens	59-80
21972530-1	2011	OBJECTIVE: To investigate the protective role of inducible heat shock protein 70 (Hsp70) against damage induced by formaldehyde.	Formaldehyde	115-127	heat shock protein family A (Hsp70) member 4	Homo sapiens	82-87
21972530-11	2011	MDA contents in HBE/hsp70 and HBE group increased with formaldehyde.	Formaldehyde	55-67	hemoglobin subunit epsilon 1	Homo sapiens	16-19
21972530-11	2011	MDA contents in HBE/hsp70 and HBE group increased with formaldehyde.	Formaldehyde	55-67	heat shock protein family A (Hsp70) member 4	Homo sapiens	20-25
21972530-11	2011	MDA contents in HBE/hsp70 and HBE group increased with formaldehyde.	Formaldehyde	55-67	hemoglobin subunit epsilon 1	Homo sapiens	30-33
21972530-14	2011	At the formaldehyde dose of 0.39 mmol/L, DPC% in HBE/hsp70 group was 3.94% which was significantly lower than that (6.25%) in HBE group (P&lt; 0.01).	Formaldehyde	7-19	hemoglobin subunit epsilon 1	Homo sapiens	49-52
21972530-14	2011	At the formaldehyde dose of 0.39 mmol/L, DPC% in HBE/hsp70 group was 3.94% which was significantly lower than that (6.25%) in HBE group (P&lt; 0.01).	Formaldehyde	7-19	heat shock protein family A (Hsp70) member 4	Homo sapiens	53-58
21972530-15	2011	At the formaldehyde dose of 1.56 mmol/L, DPC% in HBE/hsp70 group was 11.86% which was significantly lower than that (20.89%) in HBE group (P&lt;0.05).	Formaldehyde	7-19	hemoglobin subunit epsilon 1	Homo sapiens	49-52
21972530-15	2011	At the formaldehyde dose of 1.56 mmol/L, DPC% in HBE/hsp70 group was 11.86% which was significantly lower than that (20.89%) in HBE group (P&lt;0.05).	Formaldehyde	7-19	heat shock protein family A (Hsp70) member 4	Homo sapiens	53-58
21972530-16	2011	CONCLUSION: Hsp70 can reduce formaldehyde-induced damages in human bronchial epithelium cells in vitro.	Formaldehyde	29-41	heat shock protein family A (Hsp70) member 4	Homo sapiens	12-17
21310472-2	2011	METHODS: An immunohistochemistry assay was used to detect p27 in formalin-fixed paraffin-embedded ovarian tumors from 3 distinct sources.	Formaldehyde	65-73	interferon alpha inducible protein 27	Homo sapiens	58-61
21559464-5	2011	A single percutaneous IT injection of BoNT-B 0.5 U at 2 or 5 days prior to IPLT formalin reduced NK1-R internalization and C-Fos expression.	Formaldehyde	80-88	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	123-128
21300038-5	2011	Paw flexing duration was decreased in both sexes during the formalin interphase period in the CRH-treated group compared to saline control groups; however, licking of the injected paw was markedly increased by the same treatment at other time periods.	Formaldehyde	60-68	corticotropin releasing hormone	Rattus norvegicus	94-97
21371525-5	2011	These results indicate that the effects of SNI on chemogenic signaling by formalin, which is now known to involve TRPA1 receptors, differ from effects on allodynia responses.	Formaldehyde	74-82	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	114-119
20823417-7	2011	Immunohistochemistry for DKK1 (WNT), SFRP1 (SHH), NPR3 (group C), and KCNA1 (group D) could reliably and uniquely classify formalin-fixed medulloblastomas in approximately 98% of patients.	Formaldehyde	123-131	dickkopf WNT signaling pathway inhibitor 1	Homo sapiens	25-29
20823417-7	2011	Immunohistochemistry for DKK1 (WNT), SFRP1 (SHH), NPR3 (group C), and KCNA1 (group D) could reliably and uniquely classify formalin-fixed medulloblastomas in approximately 98% of patients.	Formaldehyde	123-131	natriuretic peptide receptor 3	Homo sapiens	50-54
21300038-0	2011	Central CRH administration changes formalin pain responses in male and female rats.	Formaldehyde	35-43	corticotropin releasing hormone	Rattus norvegicus	8-11
21300038-2	2011	To better evaluate the CRH-mediated behavioral alterations in the formalin inflammatory pain test, we administered CRH or the CRH receptor antagonist alpha-helical CRH(9-41) (ahCRH) intracerebroventricularly to male and female rats and compared the effects with those of saline control.	Formaldehyde	66-74	corticotropin releasing hormone	Rattus norvegicus	23-26
21300038-4	2011	In both sexes, formalin-induced responses, recorded for 60min, were affected by CRH but not by ahCRH treatment.	Formaldehyde	15-23	corticotropin releasing hormone	Rattus norvegicus	80-83
21463512-7	2011	A macroporous, polystyrene based ion-exchange resin (Diaion CR20) with surface amine group functionality has been investigated for its ability to react with aldehydes and HCN in an aerosol stream, and thus selectively reduce the yields of these compounds (in particular formaldehyde) in mainstream cigarette smoke.	Formaldehyde	270-282	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	171-174
21378549-5	2011	In this study, we investigated the potential diagnostic use of immunostaining for FOXL2 on formalin-fixed paraffin-embedded tissue sections.	Formaldehyde	91-99	forkhead box L2	Homo sapiens	82-87
21415372-5	2011	However, when Vglut2(f/f);Na(v)1.8(Cre) mice were injected with a SP antagonist before the formalin test, the second phase pain response was nearly completely abolished, whereas in control mice, the pain response was unaffected.	Formaldehyde	91-99	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6	Mus musculus	14-34
21415372-5	2011	However, when Vglut2(f/f);Na(v)1.8(Cre) mice were injected with a SP antagonist before the formalin test, the second phase pain response was nearly completely abolished, whereas in control mice, the pain response was unaffected.	Formaldehyde	91-99	tachykinin 1	Mus musculus	66-68
21385982-10	2011	Intraplanatar formalin resulted in NK1r internalization in the ipsilateral, but not contralateral, superficial dorsal horn.	Formaldehyde	14-22	tachykinin receptor 1	Rattus norvegicus	35-39
21261675-0	2011	Formaldehyde induces neurotoxicity to PC12 cells involving inhibition of paraoxonase-1 expression and activity.	Formaldehyde	0-12	paraoxonase 1	Rattus norvegicus	73-86
21425146-4	2011	METHODS: The goal of this study was to assess, in formalin-fixed, paraffin-embedded tumor tissue, the association between miR-137 promoter methylation and survival (both overall and disease free) and with prognostic factors including stage, tumor size, lymph node positivity, tumor grade, and surgical tumor margin positivity.	Formaldehyde	50-58	microRNA 137	Homo sapiens	122-129
21169610-10	2011	The injection of formalin increased the expression of alpha-2C adrenoceptor in the spinal cord (P&lt;0.05).	Formaldehyde	17-25	adrenoceptor alpha 2C	Rattus norvegicus	54-75
21436696-3	2011	METHODS: Protein expression levels of TSLC1 was explored by semiquantitative immunohistochemical staining on archival formalin-fixed, paraffin-embedded pathological specimen consisting of 30 normal ovaries, 30 ovarian cystadenomas, 40 borderline ovarian tumors, and 160 invasive ovarian carcinomas.	Formaldehyde	118-126	cell adhesion molecule 1	Homo sapiens	38-43
21402552-7	2011	Aggregates of virus-like particles (VLP) were detected by TEM in all 3 acute KD patients from whom nonembedded formalin-fixed lung tissue was available.	Formaldehyde	111-119	VHL like	Homo sapiens	36-39
21411814-4	2011	CD44 and CD133 expression was determined by immunohistochemical double staining on formalin-fixed material and subcellular protein distribution evaluated by immunofluorescence/confocal microscopy.	Formaldehyde	83-91	CD44 molecule (Indian blood group)	Homo sapiens	0-4
21411814-4	2011	CD44 and CD133 expression was determined by immunohistochemical double staining on formalin-fixed material and subcellular protein distribution evaluated by immunofluorescence/confocal microscopy.	Formaldehyde	83-91	prominin 1	Homo sapiens	9-14
21436634-4	2011	RESULTS: Fascin and S-100 required formaldehyde fixation, other markers needed cryo-preservation.	Formaldehyde	35-47	fascin actin-bundling protein 1	Homo sapiens	9-15
21436634-4	2011	RESULTS: Fascin and S-100 required formaldehyde fixation, other markers needed cryo-preservation.	Formaldehyde	35-47	S100 calcium binding protein A1	Homo sapiens	20-25
21738817-2	2011	In this study the differential expressions of candidate proteins nucleophosmin, nucleoside diphosphate kinase A/B (NDKA/B), osteoinducive factor (mimecan), and pyru-vate kinase M2 from a quantitative proteome signature for invasive ductal breast cancer were determined by immunohistochemistry on 53 tissue slices from formalin-fixed and paraffin-embedded tumor and control tissue samples from ten patients and fourteen controls.	Formaldehyde	318-326	nucleophosmin 1	Homo sapiens	65-78
21293254-2	2011	Previous work has confirmed that spinal macrophage migration inhibitory factor (MIF) contributes to the pathogenesis of formalin-induced inflammatory hyperalgesia, but the role for MIF in neuropathic pain is still not well defined.	Formaldehyde	120-128	macrophage migration inhibitory factor	Homo sapiens	80-83
21277204-1	2011	A new class of melanocortin 4 receptor (MC4r) agonists was discovered from an unexpected sidereaction in which formaldehyde caused cyclization.	Formaldehyde	111-123	melanocortin 4 receptor	Rattus norvegicus	15-38
21277204-1	2011	A new class of melanocortin 4 receptor (MC4r) agonists was discovered from an unexpected sidereaction in which formaldehyde caused cyclization.	Formaldehyde	111-123	melanocortin 4 receptor	Rattus norvegicus	40-44
21279215-7	2011	By the comparative gas sensing tests, the porous SnO(2) nanospheres exhibited a superior gas sensing performance toward ppb level 2-chloroethanol and formaldehyde vapor, implying promising applications in detecting toxic volatile organic compounds (VOCs).	Formaldehyde	150-162	strawberry notch homolog 2	Homo sapiens	49-52
21333665-2	2011	Subcutaneous administration of AMV (2, 4 or 6 mg/kg) or melittin-free AMV (1, 2 or 4 mg/kg) into the dorsum of mice inhibited both phases of formaldehyde-induced nociception.	Formaldehyde	141-153	melittin	Apis mellifera	56-64
21290074-1	2011	The structures and intermolecular interactions in the halogen bonded complexes of anaesthetics (chloroform, halothane, enflurane and isoflurane) with formaldehyde were studied by ab initio MP2 and CCSD(T) methods.	Formaldehyde	150-162	tryptase pseudogene 1	Homo sapiens	189-192
21316963-4	2011	Orally available compound 7e (CK2 IC(50)=3 nM) reduced pain in the phase II of a murine formalin model.	Formaldehyde	88-96	casein kinase 2, alpha prime polypeptide	Mus musculus	30-33
21267586-13	2011	We describe a robust method for detecting SHH, WNT, and non-SHH/WNT molecular subgroups in formalin-fixed medulloblastoma samples.	Formaldehyde	91-99	sonic hedgehog signaling molecule	Homo sapiens	42-45
21030862-2	2011	We aimed for evaluating different anti-ERCC1 antibodies on formalin-fixed tumor tissue of non-small cell lung cancer patients by automated immunohistochemistry (IHC).	Formaldehyde	59-67	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	39-44
20957681-0	2011	Spectroscopic identification of interactions of formaldehyde with bovine serum albumin.	Formaldehyde	48-60	albumin	Homo sapiens	73-86
21208810-4	2011	In addition, the activation status of VEGFR2/KDR receptors was investigated in formalin-fixed paraffin embedded tissues and related to VEGF.	Formaldehyde	79-87	kinase insert domain receptor	Homo sapiens	38-44
21208810-4	2011	In addition, the activation status of VEGFR2/KDR receptors was investigated in formalin-fixed paraffin embedded tissues and related to VEGF.	Formaldehyde	79-87	kinase insert domain receptor	Homo sapiens	45-48
21208810-4	2011	In addition, the activation status of VEGFR2/KDR receptors was investigated in formalin-fixed paraffin embedded tissues and related to VEGF.	Formaldehyde	79-87	vascular endothelial growth factor A	Homo sapiens	38-42
21326033-0	2011	Quantitative determination of estrogen receptor, progesterone receptor, and HER2 mRNA in formalin-fixed paraffin-embedded tissue--a new option for predictive biomarker assessment in breast cancer.	Formaldehyde	89-97	erb-b2 receptor tyrosine kinase 2	Homo sapiens	76-80
21198858-4	2011	The expression of apoptotic parameters was analyzed using the standard immunohistochemical method (antibodies against caspase-3, CD95, c-FLIP, XIAP, survivin, and bcl-2) on formalin-fixed and routinely processed paraffin-embedded lymph node specimens.	Formaldehyde	173-181	caspase 3	Homo sapiens	118-127
21198858-4	2011	The expression of apoptotic parameters was analyzed using the standard immunohistochemical method (antibodies against caspase-3, CD95, c-FLIP, XIAP, survivin, and bcl-2) on formalin-fixed and routinely processed paraffin-embedded lymph node specimens.	Formaldehyde	173-181	BCL2 apoptosis regulator	Homo sapiens	163-168
20957681-1	2011	The mechanism of formaldehyde-protein interactions was investigated by determining the effects of formaldehyde on the common protein bovine serum albumin (BSA).	Formaldehyde	17-29	albumin	Homo sapiens	140-153
20957681-1	2011	The mechanism of formaldehyde-protein interactions was investigated by determining the effects of formaldehyde on the common protein bovine serum albumin (BSA).	Formaldehyde	98-110	albumin	Homo sapiens	140-153
20957681-5	2011	The spectroscopic results reveal that formaldehyde exposure induces changes in the microenvironment and conformation of serum albumin, which could lead to toxic effects on the organism.	Formaldehyde	38-50	albumin	Homo sapiens	120-133
21258089-0	2011	KRAS mutation analysis in genomic DNA isolated from formalin-fixed paraffin-embedded ovarian tissue: evaluation of a strip-based reverse-hybridisation assay.	Formaldehyde	52-60	KRAS proto-oncogene, GTPase	Homo sapiens	0-4
20705523-7	2011	In addition, a 30-minute pretreatment with NP031115 (3 and 10 mg/kg, ip), a different GSK-3 beta inhibitor, also attenuated the late phase of formalin-induced nociception.	Formaldehyde	142-150	glycogen synthase kinase 3 beta	Mus musculus	86-96
21195549-5	2011	The results replicate previous findings of a significant QTL, Nociq2, on distal Chr 10 for formalin-induced inflammatory nociception and will aid in identification of the underlying candidate genes.	Formaldehyde	91-99	nociceptive sensitivity inflammatory QTL 2	Mus musculus	62-68
21184763-7	2011	Genetic ablation of the NOP receptor gene produced a statistically significant increase in nociceptive behaviour of the mutant rats in the formalin test.	Formaldehyde	139-147	crystallin, gamma B	Mus musculus	24-27
21188515-0	2011	Increases in mRNA and DREAM protein expression in the rat spinal cord after formalin induced pain.	Formaldehyde	76-84	potassium voltage-gated channel interacting protein 3	Rattus norvegicus	22-27
21188515-2	2011	Therefore, we investigate the changes of mRNA and DREAM protein in relation to the mRNA and prodynorphin protein expression on the ipsilateral side of the rat spinal cord after formalin injection (acute pain model).	Formaldehyde	177-185	prodynorphin	Rattus norvegicus	92-104
21421483-0	2011	[Effect of intrathecal ketamine injection on protein kinase C expression in the spinal dorsal horn of rats with formalin-induced pain].	Formaldehyde	112-120	protein kinase C, gamma	Rattus norvegicus	45-61
21421483-1	2011	OBJECTIVE: To investigate the expression of protein kinase C (PKC) in the spinal dorsal horn of rats with formalin-induced pain and the effect of intrathecal ketamine on PKC expression.	Formaldehyde	106-114	protein kinase C, gamma	Rattus norvegicus	44-60
21421483-1	2011	OBJECTIVE: To investigate the expression of protein kinase C (PKC) in the spinal dorsal horn of rats with formalin-induced pain and the effect of intrathecal ketamine on PKC expression.	Formaldehyde	106-114	protein kinase C, gamma	Rattus norvegicus	62-65
21421483-8	2011	RESULTS: Compared to group NS, groups K1 and K2 showed significantly decreased PIS (P&lt;0.01) in the second phase of formalin-induced pain; 24 h later, the left hindpaw thickness of group NS increased obviously in comparison with that in the control group (P&lt;0.01), whereas the thickness was significantly reduced in group K1 and K2 as compared to that in group NS (P&lt;0.05).	Formaldehyde	118-126	keratin 1	Rattus norvegicus	38-47
21421483-10	2011	CONCLUSION: Intrathecal ketamine produces obvious antinociception against formalin-induced pain in rats and inhibits the enhanced PKC expression in the spinal dorsal horn in response to formalin-induced pain, suggesting the important role of PKC in nociceptive signal transmission and modulation in the spinal cord.	Formaldehyde	186-194	protein kinase C, gamma	Rattus norvegicus	130-133
21421483-10	2011	CONCLUSION: Intrathecal ketamine produces obvious antinociception against formalin-induced pain in rats and inhibits the enhanced PKC expression in the spinal dorsal horn in response to formalin-induced pain, suggesting the important role of PKC in nociceptive signal transmission and modulation in the spinal cord.	Formaldehyde	186-194	protein kinase C, gamma	Rattus norvegicus	242-245
21075799-3	2011	Here, using a formaldehyde-based in vivo cross-linking and chromatin immunoprecipitation assay in conjunction with transcriptional, mutational and co-immunoprecipitational analyses, we show that CBC is recruited to the body of yeast gene, and then stimulates the formation of pre-initiation complex (PIC) at several yeast promoters through its interaction with Mot1p (modifier of transcription).	Formaldehyde	14-26	DNA-binding ATPase	Saccharomyces cerevisiae S288C	361-366
21239115-0	2011	RNA interference-mediated gene silence of the NR1 subunit of the NMDA receptor by subcutaneous injection of vector-encoding short hairpin RNA reduces formalin-induced nociception in the rat.	Formaldehyde	150-158	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	46-49
21239115-6	2011	In this study, we examined the effect of gene silence and antinociception on formalin-induced pain by subcutaneous injection of vector-encoding shRNA targeting the NR1 subunit of the NMDA receptor.	Formaldehyde	77-85	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	164-167
21239115-7	2011	The results revealed that subcutaneous injection of vector-expressing NR1 shRNA could effectively diminish the nociception induced by formalin stimuli and inhibit gene expression of NR1 evidenced by a decreased level of mRNA and protein.	Formaldehyde	134-142	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	70-73
21279521-12	2011	We conclude that immuno-detection of TFE3 and RT-PCR-based identification of ASPL/TFE3 fusion transcripts in formalin-fixed, paraffin-embedded tissues are powerful tools in the diagnosis of ASPS, particularly in cases with unusual morphologic features.	Formaldehyde	109-117	ASPSCR1 tether for SLC2A4, UBX domain containing	Homo sapiens	77-81
21279521-12	2011	We conclude that immuno-detection of TFE3 and RT-PCR-based identification of ASPL/TFE3 fusion transcripts in formalin-fixed, paraffin-embedded tissues are powerful tools in the diagnosis of ASPS, particularly in cases with unusual morphologic features.	Formaldehyde	109-117	transcription factor binding to IGHM enhancer 3	Homo sapiens	82-86
21279521-12	2011	We conclude that immuno-detection of TFE3 and RT-PCR-based identification of ASPL/TFE3 fusion transcripts in formalin-fixed, paraffin-embedded tissues are powerful tools in the diagnosis of ASPS, particularly in cases with unusual morphologic features.	Formaldehyde	109-117	ASPSCR1 tether for SLC2A4, UBX domain containing	Homo sapiens	190-194
21118047-5	2011	RESULTS: A total of 70 alleles of somatic mutations of EGFR, KRAS, BRAF and PIK3CA can be detected simultaneously in one reaction from one formalin-fixed and paraffin-embedded (FFPE) slide within one day.	Formaldehyde	139-147	epidermal growth factor receptor	Homo sapiens	55-59
21067242-7	2011	In addition, proteins interacting with integrin beta1 obtained using this method were validated by comparing them to those identified in a formaldehyde-supported coimmunoprecipitation experiment, protein-protein interaction databases and the literature.	Formaldehyde	139-151	integrin subunit beta 1	Homo sapiens	39-53
21380811-3	2011	Both single and repeated (x7) immobilization stress significantly attenuated the beta-endorphin and 5-hydroxytryptamine-induced antinociception in the 2nd phase of formalin response, respectively.	Formaldehyde	164-172	pro-opiomelanocortin-alpha	Mus musculus	81-95
20851148-0	2011	UMB-3, a novel rabbit monoclonal antibody, for assessing mu-opioid receptor expression in mouse, rat and human formalin-fixed and paraffin-embedded tissues.	Formaldehyde	111-119	opioid receptor, mu 1	Mus musculus	57-75
21324178-3	2011	In an effort to validate our results, we analyzed c-MYC mRNA expression in formalin-fixed paraffin-embedded tumor samples from well-documented patients with postoperative residual tumor and compared c-MYC mRNA expression with response to radio- and chemotherapy as examined by neuroradiological imaging.	Formaldehyde	75-83	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	50-55
21307248-6	2011	(3) Intrathecal treatment with inhibitors to PI3K or Akt attenuated Formalin-induced second-phase flinching behavior, as well as carrageenan-induced thermal hyperalgesia and tactile allodynia.	Formaldehyde	68-76	AKT serine/threonine kinase 1	Rattus norvegicus	53-56
21118047-5	2011	RESULTS: A total of 70 alleles of somatic mutations of EGFR, KRAS, BRAF and PIK3CA can be detected simultaneously in one reaction from one formalin-fixed and paraffin-embedded (FFPE) slide within one day.	Formaldehyde	139-147	KRAS proto-oncogene, GTPase	Homo sapiens	61-65
21118047-5	2011	RESULTS: A total of 70 alleles of somatic mutations of EGFR, KRAS, BRAF and PIK3CA can be detected simultaneously in one reaction from one formalin-fixed and paraffin-embedded (FFPE) slide within one day.	Formaldehyde	139-147	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	67-71
21118047-5	2011	RESULTS: A total of 70 alleles of somatic mutations of EGFR, KRAS, BRAF and PIK3CA can be detected simultaneously in one reaction from one formalin-fixed and paraffin-embedded (FFPE) slide within one day.	Formaldehyde	139-147	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	76-82
21107265-9	2011	Immunohistochemistry and real-time reverse transcriptase PCR revealed that isoflurane administration inhibited formalin injection-induced c-fos expression in the spinal cord.	Formaldehyde	111-119	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	138-143
20473863-6	2011	Immunohistochemical staining of GRP78 was performed on archival paraffin-embedded formalin-fixed tumor specimens obtained from 48 female breast cancer patients before chemotherapy treatment.	Formaldehyde	82-90	heat shock protein family A (Hsp70) member 5	Homo sapiens	32-37
20846665-4	2011	The present study describes a polymerase chain reaction assay that allows for complete sequencing of clonally recombined T-cell receptor (TCR) gamma chain genes from formalin-fixed and paraffin wax-embedded samples of feline lymphoma.	Formaldehyde	166-174	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	121-136
20846665-4	2011	The present study describes a polymerase chain reaction assay that allows for complete sequencing of clonally recombined T-cell receptor (TCR) gamma chain genes from formalin-fixed and paraffin wax-embedded samples of feline lymphoma.	Formaldehyde	166-174	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	138-141
20974701-4	2011	It is noteworthy that in the formalin-induced pain model PAC(1)R blockade (via PACAP6-38) also resulted in antinociception that was abolished by spinal kappa-opioid receptor blockade.	Formaldehyde	29-37	ADCYAP receptor type I	Rattus norvegicus	57-64
21166805-0	2011	Formaldehyde stimulates Mrp1-mediated glutathione deprivation of cultured astrocytes.	Formaldehyde	0-12	ATP binding cassette subfamily C member 1	Homo sapiens	24-28
21166805-7	2011	The Fal-stimulated GSH loss from viable astrocytes was completely prevented by semicarbazide-mediated chemical removal of Fal or by the application of MK571, an inhibitor of the multidrug resistance protein 1.	Formaldehyde	4-7	ATP binding cassette subfamily B member 1	Homo sapiens	178-208
21159431-5	2011	However, heat hyperalgesia after intrathecal TNF-alpha and the second-phase spontaneous pain in the formalin test were reduced in both TNFR1- and TNFR2-KO mice.	Formaldehyde	100-108	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	135-140
21145791-6	2011	While Orexin-A failed to produce a dose-dependent decrease in formalin-evoked behaviors in phase 1, it may have induced a dose-dependent decrease in formalin-evoked behaviors in early phase 2.	Formaldehyde	149-157	hypocretin neuropeptide precursor	Rattus norvegicus	6-14
21145791-13	2011	The results showed that the orexin-A plays an antinociceptive role in PAG in the interphase and the late phase of formalin test through type 1 orexin receptor dependent mechanism.	Formaldehyde	114-122	hypocretin neuropeptide precursor	Rattus norvegicus	28-36
21145791-13	2011	The results showed that the orexin-A plays an antinociceptive role in PAG in the interphase and the late phase of formalin test through type 1 orexin receptor dependent mechanism.	Formaldehyde	114-122	hypocretin neuropeptide precursor	Rattus norvegicus	28-34
21146467-0	2011	Formalin-induced c-fos expression in the brain of infant rats.	Formaldehyde	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	17-22
21146467-3	2011	We describe here the appearance of the Fos protein in the brain of fetal and infant rats following formalin-induced injury.	Formaldehyde	99-107	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	39-42
21146467-6	2011	At 3 and 14 days of age, there was a significant increase in Fos staining induced by formalin in the ventral lateral medulla.	Formaldehyde	85-93	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	61-64
21113056-1	2011	OBJECTIVE: The concordance of KRAS mutation detection between the amplification refractory mutation system-Scorpion assay and direct sequencing was evaluated with clinically available formalin-fixed, paraffin-embedded specimens of metastatic colorectal cancers.	Formaldehyde	184-192	KRAS proto-oncogene, GTPase	Homo sapiens	30-34
21145791-0	2011	Intra-periaqueductal gray matter microinjection of orexin-A decreases formalin-induced nociceptive behaviors in adult male rats.	Formaldehyde	70-78	hypocretin neuropeptide precursor	Rattus norvegicus	51-59
21145791-5	2011	In the formalin test, intra-PAG injection of orexin-A (10 nM) decreased the formalin-induced nociceptive behaviors in the interphase and phase 2, but not in phase 1, indicating an antinociceptive role of exogenous orexin-A in the PAG.	Formaldehyde	7-15	hypocretin neuropeptide precursor	Rattus norvegicus	45-53
21145791-5	2011	In the formalin test, intra-PAG injection of orexin-A (10 nM) decreased the formalin-induced nociceptive behaviors in the interphase and phase 2, but not in phase 1, indicating an antinociceptive role of exogenous orexin-A in the PAG.	Formaldehyde	76-84	hypocretin neuropeptide precursor	Rattus norvegicus	45-53
21145791-5	2011	In the formalin test, intra-PAG injection of orexin-A (10 nM) decreased the formalin-induced nociceptive behaviors in the interphase and phase 2, but not in phase 1, indicating an antinociceptive role of exogenous orexin-A in the PAG.	Formaldehyde	76-84	hypocretin neuropeptide precursor	Rattus norvegicus	214-222
20926413-8	2011	CONCLUSIONS: These data suggest that the evaluation of DNA amplificability and amplicon size is important for the success of mutation detection tests such as the KRAS test with dideoxy sequencing using formalin-fixed and paraffin-embedded tissue samples in the clinical setting.	Formaldehyde	202-210	KRAS proto-oncogene, GTPase	Homo sapiens	162-166
21159431-5	2011	However, heat hyperalgesia after intrathecal TNF-alpha and the second-phase spontaneous pain in the formalin test were reduced in both TNFR1- and TNFR2-KO mice.	Formaldehyde	100-108	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	146-151
21087659-4	2011	The important decrease in cell viability observed after 24h exposure to the highest concentrations of HCHO (1400-7000 muM) was accompanied by important LDH release and ROS production, whereas a 4h exposure to lower HCHO concentrations (350 muM) induced cell apoptosis.	Formaldehyde	102-106	latexin	Homo sapiens	118-121
21251264-8	2011	Validation of FABP-1 was performed via antibody immunohistochemistry on formalin-fixed paraffin embedded pancreatic tissue microarrays (FFPE TMA).	Formaldehyde	72-80	fatty acid binding protein 1	Homo sapiens	14-20
21087659-5	2011	Also, exposure to HCHO for 30 min dose-dependently inhibited basal and lipopolysaccharide-induced interleukin-6 (IL-6) and IL-8 production by bronchial epithelial cells.	Formaldehyde	18-22	interleukin 6	Homo sapiens	98-111
21283737-0	2011	Detection of hepatocyte growth factor (HGF) ligand-c-MET receptor activation in formalin-fixed paraffin embedded specimens by a novel proximity assay.	Formaldehyde	80-88	hepatocyte growth factor	Homo sapiens	13-37
21283737-0	2011	Detection of hepatocyte growth factor (HGF) ligand-c-MET receptor activation in formalin-fixed paraffin embedded specimens by a novel proximity assay.	Formaldehyde	80-88	hepatocyte growth factor	Homo sapiens	39-42
21283737-0	2011	Detection of hepatocyte growth factor (HGF) ligand-c-MET receptor activation in formalin-fixed paraffin embedded specimens by a novel proximity assay.	Formaldehyde	80-88	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	51-56
21224371-4	2011	EXPERIMENTAL DESIGN: EpCAM protein expression was evaluated in 74 samples of formalin-fixed, paraffin-embedded NET tissue by immunohistochemistry.	Formaldehyde	77-85	epithelial cell adhesion molecule	Homo sapiens	21-26
21087659-5	2011	Also, exposure to HCHO for 30 min dose-dependently inhibited basal and lipopolysaccharide-induced interleukin-6 (IL-6) and IL-8 production by bronchial epithelial cells.	Formaldehyde	18-22	interleukin 6	Homo sapiens	113-117
21087659-5	2011	Also, exposure to HCHO for 30 min dose-dependently inhibited basal and lipopolysaccharide-induced interleukin-6 (IL-6) and IL-8 production by bronchial epithelial cells.	Formaldehyde	18-22	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
21087659-4	2011	The important decrease in cell viability observed after 24h exposure to the highest concentrations of HCHO (1400-7000 muM) was accompanied by important LDH release and ROS production, whereas a 4h exposure to lower HCHO concentrations (350 muM) induced cell apoptosis.	Formaldehyde	102-106	latexin	Homo sapiens	240-243
21245964-5	2011	Formalin-fixed, paraffin-embedded tissues were submitted for immunohistochemical analysis with anti-TF antibody.	Formaldehyde	0-8	coagulation factor III, tissue factor	Homo sapiens	100-102
21111709-5	2011	Although the sensitivity of FANCA(-/-), FANCC(-/-) and FANCA(-/-)C(-/-) cells to formaldehyde was comparable to that of proficient cells, FANCD1mt, FANCGmt and FANCD2(-/-) cells were more sensitive to formaldehyde than the corresponding proficient cells.	Formaldehyde	81-93	Fanconi anemia, complementation group A	Mus musculus	55-60
20118221-4	2011	Upon inhalation of formalin-fixed Aspergillus fumigatus hyphal antigens, the overexpression of IDO from airway epithelial cells of these mice reduced the number of CD4(+) T cells within the inflamed lung and impaired the capacity of antigen-specific splenic CD4(+) effector T cells to secrete the cytokines IL-4, IL-5, IL-13, and IFN-gamma.	Formaldehyde	19-27	indoleamine 2,3-dioxygenase 1	Mus musculus	95-98
20118221-4	2011	Upon inhalation of formalin-fixed Aspergillus fumigatus hyphal antigens, the overexpression of IDO from airway epithelial cells of these mice reduced the number of CD4(+) T cells within the inflamed lung and impaired the capacity of antigen-specific splenic CD4(+) effector T cells to secrete the cytokines IL-4, IL-5, IL-13, and IFN-gamma.	Formaldehyde	19-27	CD4 antigen	Mus musculus	164-167
21686179-0	2011	KRAS mutation detection in paired frozen and Formalin-Fixed Paraffin-Embedded (FFPE) colorectal cancer tissues.	Formaldehyde	45-53	KRAS proto-oncogene, GTPase	Homo sapiens	0-4
21069438-3	2011	In the present study we developed a robust in situ hybridization assay using high-affinity Locked Nucleic Acid (LNA) probes that specifically detect miR-21 in formalin-fixed paraffin embedded (FFPE) tissue samples.	Formaldehyde	159-167	microRNA 21	Homo sapiens	149-155
22053985-7	2011	METHODS: Formalin-fixed paraffin-embedded archival breast tissue specimens from patients with atypical ductal hyperplasia (ADH), ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC) were examined for their expression of IRF1 and IRF5.	Formaldehyde	9-17	interferon regulatory factor 1	Homo sapiens	235-239
22053985-7	2011	METHODS: Formalin-fixed paraffin-embedded archival breast tissue specimens from patients with atypical ductal hyperplasia (ADH), ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC) were examined for their expression of IRF1 and IRF5.	Formaldehyde	9-17	interferon regulatory factor 5	Homo sapiens	244-248
22179016-2	2011	To investigate a possible involvement of the non-gastric H(+)/K(+) ATPase ATP12A (ATP1AL1) in prostate cancer, we performed immunohistochemistry in formalin-fixed, paraffin-embedded histological sections from benign and malignant human prostate lesions.	Formaldehyde	148-156	ATPase H+/K+ transporting non-gastric alpha2 subunit	Homo sapiens	74-80
22179016-2	2011	To investigate a possible involvement of the non-gastric H(+)/K(+) ATPase ATP12A (ATP1AL1) in prostate cancer, we performed immunohistochemistry in formalin-fixed, paraffin-embedded histological sections from benign and malignant human prostate lesions.	Formaldehyde	148-156	ATPase H+/K+ transporting non-gastric alpha2 subunit	Homo sapiens	82-89
22242209-2	2011	We assessed the immunohistochemical expression of p53 and P-gp using formalin-fixed, paraffin-embedded specimens in 108 patients diagnosed with de novo DLBC.	Formaldehyde	69-77	tumor protein p53	Homo sapiens	50-53
21674866-2	2011	The aim of this research was to reveal sporadic, postzygous RB1 gene mutations, in particular loss of heterozygosity (LOH), from formalin-fixed, paraffin-embedded tumor samples in RB patients, as well as tracking RB1 allele inheritance in 10 RB families.	Formaldehyde	129-137	RB transcriptional corepressor 1	Homo sapiens	60-63
20952482-9	2011	These findings, combined with our previous DAO gene mutation and induction results, indicate spinal DAO mediates both induction and maintenance of formalin-induced tonic pain and further validate spinal DAO as a novel and efficacious target molecule for the treatment of chronic pain.	Formaldehyde	147-155	D-amino-acid oxidase	Rattus norvegicus	100-103
21030527-3	2011	AIMS: To evaluate a novel multiplex assay for the rapid detection of common KRAS mutations in formalin-fixed paraffin-embedded (FFPE) tissues.	Formaldehyde	94-102	KRAS proto-oncogene, GTPase	Homo sapiens	76-80
20952482-0	2011	A series of D-amino acid oxidase inhibitors specifically prevents and reverses formalin-induced tonic pain in rats.	Formaldehyde	79-87	D-amino-acid oxidase	Rattus norvegicus	12-32
20952482-1	2011	We have found that mutation of D-amino acid oxidase (DAO) diminished formalin-induced tonic pain.	Formaldehyde	69-77	D-amino-acid oxidase	Rattus norvegicus	31-51
20952482-1	2011	We have found that mutation of D-amino acid oxidase (DAO) diminished formalin-induced tonic pain.	Formaldehyde	69-77	D-amino-acid oxidase	Rattus norvegicus	53-56
20952482-9	2011	These findings, combined with our previous DAO gene mutation and induction results, indicate spinal DAO mediates both induction and maintenance of formalin-induced tonic pain and further validate spinal DAO as a novel and efficacious target molecule for the treatment of chronic pain.	Formaldehyde	147-155	D-amino-acid oxidase	Rattus norvegicus	100-103
19879019-1	2011	It is widely known that exogenous formaldehyde exposure induces human cognitive impairment and animal memory loss; and recent studies show that formaldehyde at pathological levels induces Abeta deposition and misfolding of tau protein to form globular amyloid-like aggregates.	Formaldehyde	34-46	microtubule associated protein tau	Homo sapiens	223-226
21059758-7	2011	Ensuing in vivo studies indicate that mice lacking CaV3.2 channels display decreased analgesia to N2O in response to formalin-induced inflammatory pain.	Formaldehyde	117-125	calcium channel, voltage-dependent, T type, alpha 1H subunit	Mus musculus	51-57
21059758-8	2011	Furthermore, a superoxide dismutase and catalase mimetic, EUK-134, diminished pain responses to formalin in wild-type mice, but EUK-134 and N2O analgesia were not additive.	Formaldehyde	96-104	catalase	Mus musculus	40-48
20696815-0	2011	Feasibility and robustness of amplification refractory mutation system (ARMS)-based KRAS testing using clinically available formalin-fixed, paraffin-embedded samples of colorectal cancers.	Formaldehyde	124-132	KRAS proto-oncogene, GTPase	Homo sapiens	84-88
19879019-1	2011	It is widely known that exogenous formaldehyde exposure induces human cognitive impairment and animal memory loss; and recent studies show that formaldehyde at pathological levels induces Abeta deposition and misfolding of tau protein to form globular amyloid-like aggregates.	Formaldehyde	144-156	microtubule associated protein tau	Homo sapiens	223-226
19879019-4	2011	Formaldehyde level was analyzed by high-performance liquid chromatography (with fluorescence detection) in human urine from dementia patients (n=141), patients with hypertension (n=33) or diabetes (n=16) and healthy individuals (n=38), autopsy hippocampus samples from Alzheimer"s disease (AD) patients and brains of three types of AD animal model: namely, senescence accelerated mice (SAMP8), APP-transgenic mice and APP/PS1-transgenic mice.	Formaldehyde	0-12	presenilin 1	Mus musculus	422-425
21391734-4	2011	We evaluated CD40 expression in formalin-fixed, paraffin-embedded samples from 181 breast carcinomas using immunohistochemical staining with CD40 antibody.	Formaldehyde	32-40	CD40 molecule	Homo sapiens	13-17
19879019-9	2011	The brain formaldehyde level in APP/PS1-transgenic (n=8) mice at age of 3 months and APP-transgenic (n=8) mice at age of 6 months was increased (0.56 +- 0.02 mM), respectively, as compared with their respective age-matched controls, when these two types of AD-like animals, respectively, started to form Abeta deposits and memory loss obviously.	Formaldehyde	10-22	presenilin 1	Mus musculus	36-39
21701146-0	2011	Involvement of subtypes gamma and epsilon of protein kinase C in colon pain induced by formalin injection.	Formaldehyde	87-95	protein kinase C, gamma	Rattus norvegicus	45-61
21701146-3	2011	The colon pain behavior induced by formalin injection could be enhanced by intrathecal pretreatment with a PKC activator (PMA), and alleviated by a PKC inhibitor (H-7).	Formaldehyde	35-43	protein kinase C, gamma	Rattus norvegicus	107-110
21052001-0	2010	High sensitivity of reverse-hybridization methodology in the detection of KRAS mutations from formalin-fixed paraffin-embedded colorectal cancer samples.	Formaldehyde	94-102	KRAS proto-oncogene, GTPase	Homo sapiens	74-78
21701146-3	2011	The colon pain behavior induced by formalin injection could be enhanced by intrathecal pretreatment with a PKC activator (PMA), and alleviated by a PKC inhibitor (H-7).	Formaldehyde	35-43	protein kinase C, gamma	Rattus norvegicus	148-151
21701146-8	2011	Therefore, our findings suggest that PKC is actively involved in the colon pain induced by intracolonic injection of formalin.	Formaldehyde	117-125	protein kinase C, gamma	Rattus norvegicus	37-40
21157293-9	2011	RESULTS: Expression of PDGFR in the formalin-fixed VS tumor tissue was observed in 23 (67.5%) of the 34 samples.	Formaldehyde	36-44	platelet derived growth factor receptor beta	Homo sapiens	23-28
22194833-4	2011	METHODOLOGY/PRINCIPAL FINDINGS: We measured the expression of mir-21 and mir-143 in 142 formalin-fixed, paraffin embedded (FFPE) cervical biopsy tissue blocks, collected from Dantec Oncology Clinic, Dakar, Senegal.	Formaldehyde	88-96	microRNA 21	Homo sapiens	62-68
22194861-2	2011	As an initial step toward screening patients for cancer genotype-directed therapy, we developed a screening assay for EZH2 codon 641 mutations amenable for testing formalin-fixed clinical specimens, based on the sensitive SNaPshot single nucleotide extension technology.	Formaldehyde	164-172	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	118-122
22028896-3	2011	In this study, we immunized chickens with formalin-inactivated Stx-1 or Stx-2, and obtained immunoglobulin Y (IgY) from the egg yolk.	Formaldehyde	42-50	syntaxin 1A	Homo sapiens	63-68
21931835-4	2011	METHODOLOGY: Cannabinoid CB1 receptor immunoreactivity (CB1IR) was evaluated in formalin-fixed biopsies from individuals suffering from painful Achilles tendinosis in comparison with healthy human Achilles tendons.	Formaldehyde	80-88	cannabinoid receptor 1	Homo sapiens	25-28
21183427-4	2010	The aim of this study was to determine the localization pattern of ASPP-2 in a variety of normal and malignant human tissues, including liver, lung, prostate, small intestine, kidney, ovary, bladder, cervix, breast, stomach, bowel, gallbladder, endometrium, pancreas, spleen and thyroid.The distribution and expression of ASPP-2 was assessed by immunohistochemistry in a range of formalin-fixed, paraffin embedded, benign and malignant human tissues, using a mouse monoclonal antibody against ASPP-2.The results showed a variable pattern of positivity of ASPP-2 within the tissues studied.	Formaldehyde	380-388	tumor protein p53 binding protein 2	Homo sapiens	67-73
21075522-2	2011	TRPA1 receptors are targeted by pungent compounds from mustard and garlic and environmental irritants such as formaldehyde and acrolein.	Formaldehyde	110-122	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	0-5
20661132-7	2010	The implementation of the modified ASCO/CAP and UK HER2 IHC scoring guidelines has minimal effect on either assay interpretation, showing that Oracle can be used as a methodology for accurately determining HER2 IHC status in formalin fixed, paraffin-embedded breast cancer tissue.	Formaldehyde	225-233	erb-b2 receptor tyrosine kinase 2	Homo sapiens	206-210
21052001-5	2010	We evaluated the performance of a reverse-hybridization-based assay in the identification of the most frequent KRAS mutations on a series of 50 formalin-fixed, paraffin-embedded, advanced colorectal cancer specimens, in comparison with the direct gene sequencing technique.	Formaldehyde	144-152	KRAS proto-oncogene, GTPase	Homo sapiens	111-115
21052001-10	2010	Both reverse hybridization and gene sequencing methods have been shown to be suitable tests in detecting KRAS mutations from formalin-fixed, paraffin-embedded tumor specimens.	Formaldehyde	125-133	KRAS proto-oncogene, GTPase	Homo sapiens	105-109
21217886-7	2010	Naltrindole and GNTI attenuated the antinociceptive effect of intrathecal DUP-697 during both phases of the formalin test.	Formaldehyde	108-116	alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Rattus norvegicus	16-20
20455003-4	2010	Here we immunohistochemically assessed Y705-phosphorylated STAT3 (pY705-STAT3) in formalin-fixed, paraffin-embedded specimens of 111 patients with supratentorial glioblastomas and 25 patients with supratentorial grade III gliomas.	Formaldehyde	82-90	signal transducer and activator of transcription 3	Homo sapiens	59-64
20455003-4	2010	Here we immunohistochemically assessed Y705-phosphorylated STAT3 (pY705-STAT3) in formalin-fixed, paraffin-embedded specimens of 111 patients with supratentorial glioblastomas and 25 patients with supratentorial grade III gliomas.	Formaldehyde	82-90	signal transducer and activator of transcription 3	Homo sapiens	66-77
20959666-1	2010	We previously reported that delayed formalin fixation (DFF) has a negative effect on immunohistochemical staining of estrogen receptor (ER), progesterone receptor (PR), and HER2.	Formaldehyde	36-44	estrogen receptor 1	Homo sapiens	117-134
21059214-11	2010	Formalin-induced pain behavior was attenuated in the second phase, and this correlated with diminished tyrosine phosphorylation of N-methyl-D-aspartic acid (NMDA) receptor subunit NR2B in the dorsal horn.	Formaldehyde	0-8	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	180-184
20959666-1	2010	We previously reported that delayed formalin fixation (DFF) has a negative effect on immunohistochemical staining of estrogen receptor (ER), progesterone receptor (PR), and HER2.	Formaldehyde	36-44	estrogen receptor 1	Homo sapiens	136-138
20959666-1	2010	We previously reported that delayed formalin fixation (DFF) has a negative effect on immunohistochemical staining of estrogen receptor (ER), progesterone receptor (PR), and HER2.	Formaldehyde	36-44	progesterone receptor	Homo sapiens	141-162
20959666-1	2010	We previously reported that delayed formalin fixation (DFF) has a negative effect on immunohistochemical staining of estrogen receptor (ER), progesterone receptor (PR), and HER2.	Formaldehyde	36-44	progesterone receptor	Homo sapiens	164-166
20959666-1	2010	We previously reported that delayed formalin fixation (DFF) has a negative effect on immunohistochemical staining of estrogen receptor (ER), progesterone receptor (PR), and HER2.	Formaldehyde	36-44	erb-b2 receptor tyrosine kinase 2	Homo sapiens	173-177
20488758-6	2010	Intrathecal administration of p38 inhibitor SB203580 not only inhibited the early acute spontaneous nociceptive behaviors, but also inhibited the long-term formalin injury-induced mechanical hyperalgesia.	Formaldehyde	156-164	mitogen activated protein kinase 14	Rattus norvegicus	30-33
20813915-8	2010	Endocytosis of low concentrations of the LSEC-specific substrate, formaldehyde-treated serum albumin, was restricted to CD45 bright and dim LSEC.	Formaldehyde	66-78	protein tyrosine phosphatase, receptor type, C	Rattus norvegicus	120-124
20696160-5	2010	TIP39-KO and PTH2R-KO had increased response latency in the 55 C hot-plate test and reduced responses in the hindpaw formalin test.	Formaldehyde	117-125	parathyroid hormone 2	Mus musculus	0-5
20696160-5	2010	TIP39-KO and PTH2R-KO had increased response latency in the 55 C hot-plate test and reduced responses in the hindpaw formalin test.	Formaldehyde	117-125	parathyroid hormone 2 receptor	Mus musculus	13-18
20847279-3	2010	We have developed a pyrosequencing assay that allows both the sensitive and rapid detection of mutant IDH1 alleles in DNA extracted from formalin-fixed, paraffin-embedded tissues.	Formaldehyde	137-145	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	102-106
20488758-7	2010	Our results suggest that peripheral formalin injection induces 2 stages of microglial activation, and p38 activation in spinal microglia plays key roles in central pain modulation in formalin test respectively for the early acute phases and the late secondary long-term pain state as well.	Formaldehyde	36-44	mitogen activated protein kinase 14	Rattus norvegicus	102-105
20488758-7	2010	Our results suggest that peripheral formalin injection induces 2 stages of microglial activation, and p38 activation in spinal microglia plays key roles in central pain modulation in formalin test respectively for the early acute phases and the late secondary long-term pain state as well.	Formaldehyde	183-191	mitogen activated protein kinase 14	Rattus norvegicus	102-105
20606369-1	2010	An alkaline-based chemical antigen retrieval pretreatment step was used to enhance immunolabeling of disease-associated prion protein (PrP(Sc)) in formalin-fixed and paraffin-embedded tissue sections from cattle naturally affected with bovine spongiform encephalopathy (BSE).	Formaldehyde	147-155	PRP@	Bos taurus	135-138
20847290-0	2010	A molecular profile of focal segmental glomerulosclerosis from formalin-fixed, paraffin-embedded tissue.	Formaldehyde	63-71	actinin alpha 4	Homo sapiens	23-57
20012632-13	2010	Lewis rat repeatedly immunized with formalin-killed GAS may be a suitable animal model of chronic rheumatic valvulitis.	Formaldehyde	36-44	gastrin	Rattus norvegicus	52-55
20810270-2	2010	The bio-sniffer measures gaseous formaldehyde as fluorescence of nicotinamide adenine dinucleotide (NADH), which is the product of formaldehyde dehydrogenase (FALDH) reaction.	Formaldehyde	33-45	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	131-157
20810270-2	2010	The bio-sniffer measures gaseous formaldehyde as fluorescence of nicotinamide adenine dinucleotide (NADH), which is the product of formaldehyde dehydrogenase (FALDH) reaction.	Formaldehyde	33-45	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	159-164
20810270-5	2010	The excitation light was introduced to an optical fiber probe, and fluorescence emission of neighboring NADH, which was produced by applying formaldehyde vapor to the FALDH membrane, was concentrically measured with a photomultiplier tube.	Formaldehyde	141-153	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	167-172
20952539-4	2010	Fluorescence microscopy reveals that the distribution of dCDK12 on formaldehyde-fixed polytene chromosomes is virtually identical to that of hyperphosphorylated RNA polymerase II (RNAPII), but is distinct from that of P-TEFb (dCDK9 + dCyclin T).	Formaldehyde	67-79	Cyclin-dependent kinase 12	Drosophila melanogaster	57-63
20855640-2	2010	The purpose of this pilot study was to determine the impact of the length of fixation in 10% buffered formalin on the expression of HER2/neu by immunohistochemical analysis.	Formaldehyde	102-110	erb-b2 receptor tyrosine kinase 2	Homo sapiens	132-136
20560954-4	2010	Immunohistochemistry was applied to identify HLA-G expression in formalin-fixed paraffin-embedded cutaneous skin biopsies.	Formaldehyde	65-73	major histocompatibility complex, class I, G	Homo sapiens	45-50
20956643-6	2010	BRAF (V600E)-mutated DNA was detected in both plasma and formalin-fixed tissue specimens, and the blood samples demonstrated an increase in tyrosinase messenger RNA levels.	Formaldehyde	57-65	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	0-4
20576562-1	2010	In this paper the Mannich reaction product of dimethylamine, acetone and formaldehyde was grafted onto hydroxymethylated lignin to form a lignin-base cationic polyelectrolyte (L-DAF).	Formaldehyde	73-85	CD55 molecule (Cromer blood group)	Homo sapiens	178-181
20594581-0	2010	Diagnostic utility of dual-color break-apart chromogenic in situ hybridization for the detection of rearranged SS18 in formalin-fixed, paraffin-embedded synovial sarcoma.	Formaldehyde	119-127	SS18 subunit of BAF chromatin remodeling complex	Homo sapiens	111-115
20594584-4	2010	KIT expression was assessed by immunohistochemistry on formalin-fixed, paraffin-embedded material.	Formaldehyde	55-63	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	0-3
29913996-9	2010	Nimesulide, a highly selective cox-2 inhibitor, effectively reduces hyperalgesia due to peripherally administration of inflammatory agents like formalin.	Formaldehyde	144-152	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	31-36
20471975-7	2010	Expression of LRF was observed in several formalin-fixed tissues by immunohistochemistry and immunofluorescence.	Formaldehyde	42-50	zinc finger and BTB domain containing 7A	Homo sapiens	14-17
20621353-5	2010	Paw lickings in the early (0-5 min) and late (20-45 min) phases of the formalin test were markedly reduced in PACAP(-/-) mice.	Formaldehyde	71-79	adenylate cyclase activating polypeptide 1	Mus musculus	110-115
20740285-8	2010	For example, HER2 gene amplification is directly linked to the protein expression level in breast cancer; however, the HER2 protein is not consistently analyzed on formalin fixed tissues due to variability in fixation methods/times and the impact of this fixation on HER2 protein antigenicity.	Formaldehyde	164-172	erb-b2 receptor tyrosine kinase 2	Homo sapiens	119-123
20740285-8	2010	For example, HER2 gene amplification is directly linked to the protein expression level in breast cancer; however, the HER2 protein is not consistently analyzed on formalin fixed tissues due to variability in fixation methods/times and the impact of this fixation on HER2 protein antigenicity.	Formaldehyde	164-172	erb-b2 receptor tyrosine kinase 2	Homo sapiens	119-123
20434956-11	2010	Prior formalin enhanced intrathecal gp120-induced allodynia, suggesting that microglial priming is not limited to laparotomy and again supporting a spinal site of action.	Formaldehyde	6-14	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	36-41
20723930-3	2010	MATERIALS AND METHODS: We analyzed gene expression profiles from formalin fixed, paraffin embedded, localized prostate cancer tissues to identify genes associated with prostate specific antigen recurrence.	Formaldehyde	65-73	kallikrein related peptidase 3	Homo sapiens	168-193
20603169-13	2010	treated group increased c-Fos protein expression in nearly all subdivisions of the PAG in the formalin-injected mice.	Formaldehyde	94-102	FBJ osteosarcoma oncogene	Mus musculus	24-29
20546897-7	2010	Interestingly, gel filtration and formaldehyde cross-linking indicated that GAGE12I forms tetramers.	Formaldehyde	34-46	G antigen 12I	Homo sapiens	76-83
20862299-6	2010	METHODOLOGY/PRINCIPAL FINDINGS: Here we show that the antinociceptive effect of acetaminophen at an oral dose lacking hypolocomotor activity is absent in FAAH and TRPV(1) knockout mice in the formalin, tail immersion and von Frey tests.	Formaldehyde	192-200	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	163-170
20931533-3	2010	HER2 expression level and HER2 gene copy number in formalin-fixed and paraffin embedded tumor samples were detected by immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH), and the relationship between HER2 gene GH and clinicopathological characteristics were analyzed.	Formaldehyde	51-59	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-4
20931533-3	2010	HER2 expression level and HER2 gene copy number in formalin-fixed and paraffin embedded tumor samples were detected by immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH), and the relationship between HER2 gene GH and clinicopathological characteristics were analyzed.	Formaldehyde	51-59	erb-b2 receptor tyrosine kinase 2	Homo sapiens	26-30
20931533-3	2010	HER2 expression level and HER2 gene copy number in formalin-fixed and paraffin embedded tumor samples were detected by immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH), and the relationship between HER2 gene GH and clinicopathological characteristics were analyzed.	Formaldehyde	51-59	erb-b2 receptor tyrosine kinase 2	Homo sapiens	26-30
20519626-3	2010	Here, using 2 orthogonal technologies for detecting cancer-associated mutations in formalin-fixed, paraffin-embedded material, we identified the oncogenic BRAF V600E mutation in 35 of 61 archived specimens (57%).	Formaldehyde	83-91	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	155-159
20589712-3	2010	Formalin-fixed paraffin-embedded specimens were stained for VEGF and cortactin, and the correlation between the staining, clinicopathological parameters and prognostic power were analyzed.	Formaldehyde	0-8	cortactin	Homo sapiens	69-78
20589712-3	2010	Formalin-fixed paraffin-embedded specimens were stained for VEGF and cortactin, and the correlation between the staining, clinicopathological parameters and prognostic power were analyzed.	Formaldehyde	0-8	vascular endothelial growth factor A	Homo sapiens	60-64
20631257-1	2010	In a search for proteins differentially cross-linked to DNA by cisplatin or formaldehyde in normal breast epithelial and breast cancer cell lines, we identified peroxiredoxin 1 (PRDX1) as a protein preferentially cross-linked to DNA in estrogen receptor negative (ER-) MDA-MB-231 but not in estrogen receptor positive (ER+) MCF7 breast cancer cells.	Formaldehyde	76-88	peroxiredoxin 1	Homo sapiens	161-176
19766362-3	2010	The expression of Id-1 protein was assessed in formalin-fixed, paraffin-embedded surgical specimens of ACCs by immunohistochemical staining.	Formaldehyde	47-55	inhibitor of DNA binding 1, HLH protein	Homo sapiens	18-22
20573163-10	2010	Also discussed here are the formaldehyde-releasers MDM hydantoin, methenamine, N-methylolchloracetamide, paraformaldehyde, and Preventol D2.	Formaldehyde	28-40	secreted LY6/PLAUR domain containing 1	Homo sapiens	51-54
20736744-11	2010	The TMPRSS2 dual-color break-apart FISH probe cocktail provides a simple and reliable method for the detection of TMPRSS2-related genetic alterations in formalin-fixed paraffin-embedded tissue.	Formaldehyde	153-161	transmembrane serine protease 2	Homo sapiens	4-11
20736744-11	2010	The TMPRSS2 dual-color break-apart FISH probe cocktail provides a simple and reliable method for the detection of TMPRSS2-related genetic alterations in formalin-fixed paraffin-embedded tissue.	Formaldehyde	153-161	transmembrane serine protease 2	Homo sapiens	114-121
20041308-3	2010	As rarely reported previously, the MLPA assay was also used to examine DNA from formalin fixed paraffin embedded (FFPE) normal tissues of other affected subjects in the family and it was the only effective method to perform a complete segregation analysis of the BRCA1 ins6kbEx13 mutation in the family.	Formaldehyde	80-88	BRCA1 DNA repair associated	Homo sapiens	263-268
20807921-0	2010	Detection of PrP(Sc) in formalin-fixed, paraffin-embedded tissue by Western blot differentiates classical scrapie, Nor98 scrapie, and bovine spongiform encephalopathy.	Formaldehyde	24-32	PRP@	Bos taurus	13-16
20807921-2	2010	Identification of the prion protein associated with scrapie (PrP(Sc)) in the central nervous system is typically based upon immunoassays including immunohistochemistry (IHC) using formalin-fixed tissues or Western blot (WB) assays using fresh and/or frozen, non-formalin-fixed tissues.	Formaldehyde	180-188	PRP@	Bos taurus	61-64
20807921-2	2010	Identification of the prion protein associated with scrapie (PrP(Sc)) in the central nervous system is typically based upon immunoassays including immunohistochemistry (IHC) using formalin-fixed tissues or Western blot (WB) assays using fresh and/or frozen, non-formalin-fixed tissues.	Formaldehyde	262-270	PRP@	Bos taurus	61-64
20807921-7	2010	Recently, a WB method using formalin-fixed, paraffin-embedded (FFPE) tissue to identify PrP(Sc) was developed that successfully identified PrP(Sc) in sheep affected by classical scrapie.	Formaldehyde	28-36	major prion protein	Ovis aries	88-91
20807921-7	2010	Recently, a WB method using formalin-fixed, paraffin-embedded (FFPE) tissue to identify PrP(Sc) was developed that successfully identified PrP(Sc) in sheep affected by classical scrapie.	Formaldehyde	28-36	major prion protein	Ovis aries	139-142
20856883-9	2010	MC1R mutant females, and females overexpressing the endogenous MC1R antagonist, agouti signalling protein, had a reduced formalin-induced inflammatory pain response, and a delayed development of inflammation-induced hyperalgesia and allodynia.	Formaldehyde	121-129	melanocortin 1 receptor	Mus musculus	0-4
20856883-9	2010	MC1R mutant females, and females overexpressing the endogenous MC1R antagonist, agouti signalling protein, had a reduced formalin-induced inflammatory pain response, and a delayed development of inflammation-induced hyperalgesia and allodynia.	Formaldehyde	121-129	melanocortin 1 receptor	Mus musculus	63-67
20825656-12	2010	Quantitative RT-PCR analysis of RNA cross-linked with Gag in formaldehyde-fixed cells demonstrated that the compensatory mutations reduced the association between Gag and spliced HIV-1 RNA, thereby effectively preventing these RNAs from being packaged into the virion.	Formaldehyde	61-73	Pr55(Gag)	Human immunodeficiency virus 1	54-57
20825656-12	2010	Quantitative RT-PCR analysis of RNA cross-linked with Gag in formaldehyde-fixed cells demonstrated that the compensatory mutations reduced the association between Gag and spliced HIV-1 RNA, thereby effectively preventing these RNAs from being packaged into the virion.	Formaldehyde	61-73	Pr55(Gag)	Human immunodeficiency virus 1	163-166
20597554-0	2010	Citric acid antigen retrieval (CAAR) for tryptic peptide imaging directly on archived formalin-fixed paraffin-embedded tissue.	Formaldehyde	86-94	CTPL1	Homo sapiens	0-36
20127992-8	2010	Formalin-fixed tissues were used for SMO immunohistochemistry.	Formaldehyde	0-8	spermine oxidase	Homo sapiens	37-40
20616362-5	2010	The PIK3CA HRMA assay was evaluated by performing repeatability, sensitivity, and comparison with DNA sequencing studies and was further validated in 129 formalin-fixed paraffin-embedded breast tissue samples: 99 tumors, 20 noncancerous, and 10 fibroadenomas.	Formaldehyde	154-162	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	4-10
20631257-1	2010	In a search for proteins differentially cross-linked to DNA by cisplatin or formaldehyde in normal breast epithelial and breast cancer cell lines, we identified peroxiredoxin 1 (PRDX1) as a protein preferentially cross-linked to DNA in estrogen receptor negative (ER-) MDA-MB-231 but not in estrogen receptor positive (ER+) MCF7 breast cancer cells.	Formaldehyde	76-88	peroxiredoxin 1	Homo sapiens	178-183
20609425-5	2010	Using western blotting assays, we detected the SNARE proteins in hippocampal synaptosomes and identified decrease of both SNAP25 and VAMP2 after formaldehyde treatment without significant changes of another SNARE protein, syntaxin 1, and synaptic vesicle marker, synaptophysin.	Formaldehyde	145-157	synaptosome associated protein 25	Rattus norvegicus	122-128
20562022-0	2010	Selective potentiation of gabapentin-mediated antinociception in the rat formalin test by the nicotinic acetylcholine receptor agonist ABT-594.	Formaldehyde	73-81	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	94-126
20609425-5	2010	Using western blotting assays, we detected the SNARE proteins in hippocampal synaptosomes and identified decrease of both SNAP25 and VAMP2 after formaldehyde treatment without significant changes of another SNARE protein, syntaxin 1, and synaptic vesicle marker, synaptophysin.	Formaldehyde	145-157	vesicle-associated membrane protein 2	Rattus norvegicus	133-138
20609425-5	2010	Using western blotting assays, we detected the SNARE proteins in hippocampal synaptosomes and identified decrease of both SNAP25 and VAMP2 after formaldehyde treatment without significant changes of another SNARE protein, syntaxin 1, and synaptic vesicle marker, synaptophysin.	Formaldehyde	145-157	synaptophysin	Rattus norvegicus	263-276
20609425-7	2010	These results suggested that the specific decrease of SNAP25 and VAMP2 in hippocampal synaptosomes served as a potential contributing mechanism underlying learning and memory impairments after repetitive formaldehyde inhalation treatment.	Formaldehyde	204-216	synaptosome associated protein 25	Rattus norvegicus	54-60
20609425-7	2010	These results suggested that the specific decrease of SNAP25 and VAMP2 in hippocampal synaptosomes served as a potential contributing mechanism underlying learning and memory impairments after repetitive formaldehyde inhalation treatment.	Formaldehyde	204-216	vesicle-associated membrane protein 2	Rattus norvegicus	65-70
20739576-6	2010	However, ERK1 deletion did delay formalin-induced long-term heat hypersensitivity, without affecting formalin-induced mechanical hypersensitivity, suggesting that ERK1 partially shapes long-term responses to formalin.	Formaldehyde	33-41	mitogen-activated protein kinase 3	Mus musculus	9-13
20739576-9	2010	Additionally, systemic MEK inhibition with SL327 (alpha-[amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile) attenuated formalin-induced spontaneous behaviors similarly in wild-type and ERK1 KO mice, indicating that unrelated signaling pathways do not functionally compensate for the loss of ERK1.	Formaldehyde	145-153	midkine	Mus musculus	23-26
20599546-6	2010	Simulations of the uncomplexed inhibitor CIP show structural rearrangements and increased flexibility of the interfacial loop containing the critical residue E240, which becomes fully hydrated and available for interactions with one of several positively charged residues in the kinase.	Formaldehyde	158-162	muscular LMNA interacting protein	Homo sapiens	41-44
20808855-3	2010	METHODOLOGY/PRINCIPAL FINDINGS: FAAH immunoreactivity (FAAH-IR) was assessed in formalin-fixed paraffin-embedded non-malignant and tumour cores from 412 patients with prostate cancer.	Formaldehyde	80-88	fatty acid amide hydrolase	Homo sapiens	32-36
20808855-3	2010	METHODOLOGY/PRINCIPAL FINDINGS: FAAH immunoreactivity (FAAH-IR) was assessed in formalin-fixed paraffin-embedded non-malignant and tumour cores from 412 patients with prostate cancer.	Formaldehyde	80-88	fatty-acid amide hydrolase-like	Rattus norvegicus	55-59
20482381-9	2010	CONCLUSIONS: A novel, qualitative, sensitive, reliable and high throughput liquidchip technology has been developed for detecting KRAS mutations using clinical serum and formalin-fixed and paraffin-embedded samples.	Formaldehyde	170-178	KRAS proto-oncogene, GTPase	Homo sapiens	130-134
20574164-3	2010	Dynamin 2 expression was evaluated at protein level in thirty seven paraffin-embedded, formalin-fixed tissues including four normal cervix tissues and compared with pathologic risk factors for recurrence after surgery in thirty three patients with squamous cell carcinoma of the cervix.	Formaldehyde	87-95	dynamin 2	Homo sapiens	0-9
20710042-9	2010	Nuclear IGF-1R is detectable in primary renal cancer cells, formalin-fixed tumors, preinvasive lesions in the breast, and nonmalignant tissues characterized by a high proliferation rate.	Formaldehyde	60-68	insulin like growth factor 1 receptor	Homo sapiens	8-14
20702721-7	2010	Furthermore, intrathecal injection of BNP yielded inhibitory effects on formalin-induced flinching behavior and CFA-induced thermal hyperalgesia in rats.	Formaldehyde	72-80	natriuretic peptide B	Rattus norvegicus	38-41
19950227-6	2010	Risk of TP53 mutation was significantly increased in association with duration (&gt; or =24 years, OR 5.1, 95% CI, 1.5-17.1), average level (&gt;2 mg/m(3); OR 3.6, 95% CI, 1.2-10.8) and cumulative level (&gt; or =30 mg/m(3) x years; OR 3.5, 95% CI, 1.2-10.7) of wood-dust exposure; adjustment for formaldehyde affected the ORs only slightly.	Formaldehyde	297-309	tumor protein p53	Homo sapiens	8-12
21090290-2	2010	The average concentrations of formaldehyde in ambient air, rain and fog are 4.0 x 10(-10), 2.19 micromol/L and 2.94 micromol/L, respectively.	Formaldehyde	30-42	zinc finger protein, FOG family member 1	Homo sapiens	68-71
21090290-6	2010	The further founding is that Hme/H* in fog is higher than in rain, proving the result of Mangdang Mountain that the concentration of formaldehyde in fog is higher than in rain.	Formaldehyde	133-145	zinc finger protein, FOG family member 1	Homo sapiens	39-42
21090290-6	2010	The further founding is that Hme/H* in fog is higher than in rain, proving the result of Mangdang Mountain that the concentration of formaldehyde in fog is higher than in rain.	Formaldehyde	133-145	Ras interacting protein 1	Homo sapiens	61-65
21090290-6	2010	The further founding is that Hme/H* in fog is higher than in rain, proving the result of Mangdang Mountain that the concentration of formaldehyde in fog is higher than in rain.	Formaldehyde	133-145	zinc finger protein, FOG family member 1	Homo sapiens	149-152
21090290-6	2010	The further founding is that Hme/H* in fog is higher than in rain, proving the result of Mangdang Mountain that the concentration of formaldehyde in fog is higher than in rain.	Formaldehyde	133-145	Ras interacting protein 1	Homo sapiens	171-175
21761367-1	2010	A phospho-tyrosine 537-ERalpha (p-Y537-ERalpha) antibody was validated for immunohistochemistry of formalin-fixed paraffin-embedded human breast cancer biopsies and used to interrogate multiple ER positive breast cancer cases present on tissue microarrays already constructed by the Manitoba Breast Tumor Bank.	Formaldehyde	99-107	estrogen receptor 1	Homo sapiens	23-30
21761367-1	2010	A phospho-tyrosine 537-ERalpha (p-Y537-ERalpha) antibody was validated for immunohistochemistry of formalin-fixed paraffin-embedded human breast cancer biopsies and used to interrogate multiple ER positive breast cancer cases present on tissue microarrays already constructed by the Manitoba Breast Tumor Bank.	Formaldehyde	99-107	estrogen receptor 1	Homo sapiens	39-46
20564221-0	2010	Development of a monoclonal antibody that specifically detects tissue inhibitor of metalloproteinase-4 (TIMP-4) in formalin-fixed, paraffin-embedded human tissues.	Formaldehyde	115-123	TIMP metallopeptidase inhibitor 4	Homo sapiens	63-102
20564221-0	2010	Development of a monoclonal antibody that specifically detects tissue inhibitor of metalloproteinase-4 (TIMP-4) in formalin-fixed, paraffin-embedded human tissues.	Formaldehyde	115-123	TIMP metallopeptidase inhibitor 4	Homo sapiens	104-110
20564221-6	2010	In contrast, the antibody displayed high specificity and sensitivity for TIMP-4 including in formalin-fixed and paraffin-embedded specimens of human breast specimens.	Formaldehyde	93-101	TIMP metallopeptidase inhibitor 4	Homo sapiens	73-79
20532661-3	2010	Formalin-fixed paraffin-embedded specimens were stained for cortactin and the correlation between the staining, its clinicopathological parameters, and its prognostic power were analyzed statistically.	Formaldehyde	0-8	cortactin	Homo sapiens	60-69
20688016-1	2010	OBJECTIVE: To compare immunohistochemical estrogen receptor expression on formalin-fixed, paraffin-embedded breast carcinoma tissue sections by using regular, extended microwave heating and pressure cooker technique for heat induced antigen retrieval.	Formaldehyde	74-82	estrogen receptor 1	Homo sapiens	42-59
20388062-4	2010	MATERIALS AND METHODS: NDRG1 was detected at its protein level by immunohistochemistry in formalin-fixed and paraffin-embedded sections with a total of 110 pair gastric cancer specimens including tumor and corresponding paraneoplastic tissues; NDRG1 mRNA was detected by real time-polymerase chain reaction.	Formaldehyde	90-98	N-myc downstream regulated 1	Homo sapiens	23-28
20714877-2	2010	Real-time quantitative RT-PCR (Taqman) was used to detect the mRNA expression of TS, TP and DPD in formalin-fixed and paraffin-embedded 106 samples of epithelial ovarian cancer and 29 normal ovaries.	Formaldehyde	99-107	dihydropyrimidine dehydrogenase	Homo sapiens	92-95
20546112-5	2010	The expression of TWEAK and Fn14 was investigated by immunohistochemistry in formalin-fixed, paraffin-embedded tissues.	Formaldehyde	77-85	TNF superfamily member 12	Homo sapiens	18-23
20712532-5	2010	By using this assay, we determined the mutational status of KRAS in 527 out of 540 (97.6%) formalin-fixed paraffin-embedded tissues from mCRC patients.	Formaldehyde	91-99	KRAS proto-oncogene, GTPase	Homo sapiens	60-64
20814077-2	2010	Here, using two other pain rat models, the tail-flick and the formalin tests, we assess the potency and duration of the antinociceptive action of opiorphin with reference to morphine.	Formaldehyde	62-70	opiorphin prepropeptide	Homo sapiens	146-155
20814077-6	2010	The analgesic response induced by opiorphin in the formalin-induced pain model preferentially requires activation of endogenous mu-opioid pathways.	Formaldehyde	51-59	opiorphin prepropeptide	Homo sapiens	34-43
20573451-8	2010	Conversely, an evaluation of pain-related behavior in the formalin model indicates that anxiety is directly related to prolonged hyperalgesia prevented by systemic benzodiazepine or CCK-2 receptor antagonist treatments.	Formaldehyde	58-66	cholecystokinin B receptor	Homo sapiens	182-196
20605331-3	2010	In wild-type mice, hindpaw injections of capsaicin, formalin, mustard oil or menthol induce expression of ATF3 in distinct subpopulations of sensory neurons.	Formaldehyde	52-60	activating transcription factor 3	Mus musculus	106-110
20605331-6	2010	By contrast, only low doses of formalin or mustard oil failed to induce ATF3 in TRPA1 null mice, indicating that injections of high doses (&gt;0.5%) of formalin or mustard oil recruit both TRPA1- and non-TRPA1 expressing primary afferent fibers.	Formaldehyde	152-160	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	189-194
20605331-6	2010	By contrast, only low doses of formalin or mustard oil failed to induce ATF3 in TRPA1 null mice, indicating that injections of high doses (&gt;0.5%) of formalin or mustard oil recruit both TRPA1- and non-TRPA1 expressing primary afferent fibers.	Formaldehyde	152-160	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	189-194
20405124-5	2010	Oral immunization of mice with formalin-killed bacteria expressing hybrid II fimbriae induced strong CFA/I- and CS2-specific serum IgG + IgM and fecal IgA antibody responses, which were higher than those achieved by similar immunization with the reference strains.	Formaldehyde	31-39	calsyntenin 2	Mus musculus	112-115
20346586-3	2010	On degradation of nitrogen monoxide (NO) and formaldehyde (HCHO) at typical concentrations for indoor air quality, these nanocrystalline Zn(2)SnO(4) microcubes exhibited superior photocatalytic activity to the hydrothermally synthesized ZnO, SnO(2), and Degussa TiO(2) P25, as well as C doped TiO(2) under UV-vis light irradiation.	Formaldehyde	45-57	strawberry notch homolog 2	Homo sapiens	142-145
20461249-1	2010	An ab initio study of the complexes formed by hypohalous acids (HOX, X = F, Cl and Br) with formaldehyde has been carried out at the MP2/aug-cc-pVTZ computational level.	Formaldehyde	92-104	tryptase pseudogene 1	Homo sapiens	133-136
20216404-0	2010	Protocol for PTEN expression by immunohistochemistry in formalin-fixed paraffin-embedded human breast carcinoma.	Formaldehyde	56-64	phosphatase and tensin homolog	Homo sapiens	13-17
20834076-11	2010	Well designed studies are needed to further investigate the performance of various anti-BRCA1 antibodies in formalin- fixed paraffin-embedded tissue samples, assess their association with BRCA1 gene mutations and determine clinical usefulness of BRCA1 immunohistochemistry.	Formaldehyde	108-116	BRCA1 DNA repair associated	Homo sapiens	88-93
20216404-4	2010	Here, we describe an automated and reliable protocol for PTEN protein expression by immunohistochemistry in formalin-fixed paraffin-embedded tissue that can be easily incorporated into clinical trials.	Formaldehyde	108-116	phosphatase and tensin homolog	Homo sapiens	57-61
20557864-2	2010	METHODS: Using the fluorescence property of QDs and indirect immunofluorescence methods to detect the IgA and complement C3 in formalin-fixed paraffin-embedded (FFPE) tissues of IgAN.	Formaldehyde	127-135	complement C3	Homo sapiens	110-123
20557864-2	2010	METHODS: Using the fluorescence property of QDs and indirect immunofluorescence methods to detect the IgA and complement C3 in formalin-fixed paraffin-embedded (FFPE) tissues of IgAN.	Formaldehyde	127-135	IGAN1	Homo sapiens	178-182
20381118-6	2010	Histologic examination revealed a massive deposition of Congo red-positive amyloid identified as amyloid protein transthyretin by both immunohistochemistry and mass spectrometry using formalin-fixed, paraffin-embedded tissues.	Formaldehyde	184-192	transthyretin	Homo sapiens	113-126
20216402-0	2010	Double immunohistochemical staining method for HIF-1alpha and its regulators PHD2 and PHD3 in formalin-fixed paraffin-embedded tissues.	Formaldehyde	94-102	hypoxia inducible factor 1 subunit alpha	Homo sapiens	47-57
20216402-0	2010	Double immunohistochemical staining method for HIF-1alpha and its regulators PHD2 and PHD3 in formalin-fixed paraffin-embedded tissues.	Formaldehyde	94-102	egl-9 family hypoxia inducible factor 1	Homo sapiens	77-81
20227160-6	2010	STUDY DESIGN: A retrospective study was performed on archival paraffin-embedded formalin-fixed tissue samples of DCIS and MICB from women who had undergone surgery.	Formaldehyde	80-88	MHC class I polypeptide-related sequence B	Homo sapiens	122-126
19655318-7	2010	Subsequent investigations revealed that microinjection of only the nicotinic antagonist, mecamylamine, into the lateral SuM selectively attenuated the responses elicited in CA1 by stimulation of the RPO or on nociceptive stimulation with hind paw injection of formalin (5%, 0.05 ml); whereas, microinjection of mecamylamine into the medial SuM did not affect the hippocampal responses elicited by either type of stimulation.	Formaldehyde	260-268	carbonic anhydrase 1	Rattus norvegicus	173-176
19655318-8	2010	Furthermore, application of mecamylamine into the lateral SuM attenuated the CA1 responses induced by injection of formalin into the contralateral, but not the ipsilateral hind paw.	Formaldehyde	115-123	carbonic anhydrase 1	Rattus norvegicus	77-80
20431032-3	2010	The aim of this study was to develop and evaluate the performance of a novel real-time PCR and post-PCR fluorescence melting curve analysis assay for the detection of IDH1 and IDH2 mutations in routine formalin-fixed, paraffin-embedded tissues of brain biopsies.	Formaldehyde	202-210	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	167-171
20431032-3	2010	The aim of this study was to develop and evaluate the performance of a novel real-time PCR and post-PCR fluorescence melting curve analysis assay for the detection of IDH1 and IDH2 mutations in routine formalin-fixed, paraffin-embedded tissues of brain biopsies.	Formaldehyde	202-210	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	176-180
20412385-6	2010	In CCI rats, formalin-induced nociception and increases in spinal glutamate concentrations were significantly attenuated by pre-treatment with CPCCOEt, MPEP, APDC, or l-AP4.	Formaldehyde	13-21	replication initiator 1	Rattus norvegicus	169-172
20431032-9	2010	In summary, we report here the real-time PCR/fluorescence melting curve analysis assay that provides rapid and sensitive detection of IDH mutations in formalin-fixed, paraffin-embedded tissues, and is therefore useful as a powerful adjunct diagnostic tool for refining histopathological diagnosis of brain lesions and guiding patient management.	Formaldehyde	151-159	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	134-137
20431034-3	2010	Therefore, we assessed Sanger sequencing, pyrosequencing, and melting curve analysis for the detection of KRAS codon 12/13 mutations in formalin-fixed paraffin-embedded samples, including 58 primary and 42 metastatic colorectal adenocarcinomas, 63 primary and 17 metastatic lung adenocarcinomas, and 20 normal colon samples.	Formaldehyde	136-144	KRAS proto-oncogene, GTPase	Homo sapiens	106-110
20442643-4	2010	Here we report on a novel monoclonal antibody recognizing the c-myc protein in formalin-fixed, paraffin-embedded tissue which we used to evaluate a spectrum of aggressive B-cell lymphomas by standard immunohistochemistry.	Formaldehyde	79-87	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	62-67
20382636-3	2010	Formalin-fixed paraffin-embedded specimens were stained for vascular endothelial growth factor-A and E-cadherin and the correlation between the staining, its clinicopathological parameters and its prognostic power were analyzed statistically.	Formaldehyde	0-8	vascular endothelial growth factor A	Homo sapiens	60-96
20382636-3	2010	Formalin-fixed paraffin-embedded specimens were stained for vascular endothelial growth factor-A and E-cadherin and the correlation between the staining, its clinicopathological parameters and its prognostic power were analyzed statistically.	Formaldehyde	0-8	cadherin 1	Homo sapiens	101-111
21151530-1	2010	We report here the results of the analytical validation of assays that measure HER2 total protein (H2T) and HER2 homodimer (H2D) expression in Formalin Fixed Paraffin Embedded (FFPE) breast cancer tumors as well as cell line controls.	Formaldehyde	143-151	erb-b2 receptor tyrosine kinase 2	Homo sapiens	79-83
21151530-1	2010	We report here the results of the analytical validation of assays that measure HER2 total protein (H2T) and HER2 homodimer (H2D) expression in Formalin Fixed Paraffin Embedded (FFPE) breast cancer tumors as well as cell line controls.	Formaldehyde	143-151	erb-b2 receptor tyrosine kinase 2	Homo sapiens	108-112
20573258-2	2010	miRs may be less prone to degradation during formalin fixation, facilitating miR expression studies in formalin-fixed paraffin-embedded (FFPE) tissue.	Formaldehyde	45-53	membrane associated ring-CH-type finger 8	Homo sapiens	0-3
20573258-2	2010	miRs may be less prone to degradation during formalin fixation, facilitating miR expression studies in formalin-fixed paraffin-embedded (FFPE) tissue.	Formaldehyde	103-111	membrane associated ring-CH-type finger 8	Homo sapiens	0-3
20554879-5	2010	Moreover, systemic administration of OXT dose-dependently produced analgesia in both wild-type and OTR knock-out mice in three different assays, the radiant-heat paw withdrawal test, the von Frey test of mechanical sensitivity, and the formalin test of inflammatory nociception.	Formaldehyde	236-244	oxytocin	Mus musculus	37-40
20526464-2	2010	Acylnitroso-derived hetero-Diels Alder adducts and related allyl acetates were shown to be substrates for Pd(0)/InI-mediated allylations of formaldehyde-related species to provide homoallylic alcohols.	Formaldehyde	140-152	PHD finger protein 5A	Homo sapiens	112-115
20102291-5	2010	Immunohistochemistry for MMP-1 was performed on formalin fixed and paraffin embedded sections.	Formaldehyde	48-56	matrix metallopeptidase 1	Homo sapiens	25-30
20478579-5	2010	MATERIALS AND METHODS: PITX2 methylation status was assessed in formalin fixed, paraffin embedded prostatectomy tumor tissue samples from 476 patients from a total of 4 institutions on customized EpiChip PITX2 microarrays.	Formaldehyde	64-72	paired like homeodomain 2	Homo sapiens	23-28
20347909-9	2010	Therefore, induction of tumor-associated p53 mutation likely occurs after several other key events in formaldehyde-induced carcinogenesis.	Formaldehyde	102-114	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	41-44
20303182-5	2010	TLR15 expression increased significantly in response to stimulation with live, heat-killed and formalin-killed SE, EC, and EG, but was unaffected by stimulation with known TLR agonists and R. equi.	Formaldehyde	95-103	toll-like receptor 15	Gallus gallus	0-5
20360144-6	2010	Molecular analysis of formalin-fixed specimens of the breast tumour confirmed the known FLT3 and NPM1 gene mutations.	Formaldehyde	22-30	fms related receptor tyrosine kinase 3	Homo sapiens	88-92
20463582-8	2010	RESULTS: The results revealed that subcutaneous injection of 1 nmol NR1 siRNA effectively diminished the nociception induced by formalin and complete Freund"s adjuvant stimuli and attenuated the level of NR1 messenger RNA and protein in skin and ipsilateral dorsal root ganglion.	Formaldehyde	128-136	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	68-71
20360144-6	2010	Molecular analysis of formalin-fixed specimens of the breast tumour confirmed the known FLT3 and NPM1 gene mutations.	Formaldehyde	22-30	nucleophosmin 1	Homo sapiens	97-101
20585536-5	2010	CD31 expression in TLA-treated or formalin-fixed T. gondii-injected mice was lower than the control mice.	Formaldehyde	34-42	platelet/endothelial cell adhesion molecule 1	Mus musculus	0-4
19863700-0	2010	C3d immunohistochemistry on formalin-fixed tissue is a valuable tool in the diagnosis of bullous pemphigoid of the skin.	Formaldehyde	28-36	endogenous retrovirus group K member 13	Homo sapiens	0-3
19863700-2	2010	We investigated the expression of C3d in formalin-fixed, paraffin-embedded tissue of autoimmune bullous dermatoses.	Formaldehyde	41-49	endogenous retrovirus group K member 13	Homo sapiens	34-37
20222056-2	2010	In this work, we have followed this strategy to improve the quality of the NEMO potential for the formaldehyde dimer by introducing local quadrupole moments and higher-order polarizabilities.	Formaldehyde	98-110	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	75-79
20585536-6	2010	Accordingly, the present study shows that the treatment of mice with formalin-fixed T. gondii or TLA in the murine sarcoma-180 tumor model results in a decrease of both tumor size and CD31 expression.	Formaldehyde	69-77	platelet/endothelial cell adhesion molecule 1	Mus musculus	184-188
20428818-5	2010	Validation study using real-time quantitative RT-PCR in formalin-fixed paraffin-embedded cancer tissues and paired normal epithelia obtained by Laser-captured microdissection revealed that miR-205 showed highest expression in both malignant and benign squamous epithelia, although it was less expressed in cell lines and tissues other than squamous epithelia.	Formaldehyde	56-64	microRNA 205	Homo sapiens	189-196
20399559-6	2010	We show here that female C57BL/6 mice immunized with myelin oligodendrocyte glycoprotein (MOG(35-55)) display a significant decrease in elicited pain behaviours in response to formalin injection.	Formaldehyde	176-184	myelin oligodendrocyte glycoprotein	Mus musculus	53-88
20399559-6	2010	We show here that female C57BL/6 mice immunized with myelin oligodendrocyte glycoprotein (MOG(35-55)) display a significant decrease in elicited pain behaviours in response to formalin injection.	Formaldehyde	176-184	myelin oligodendrocyte glycoprotein	Mus musculus	90-93
20347000-0	2010	Formaldehyde induces apoptosis through decreased Prx 2 via p38 MAPK in lung epithelial cells.	Formaldehyde	0-12	peroxiredoxin 2	Homo sapiens	49-54
20648783-8	2010	Nociception, induced by intraplantar injection of formalin, was mitigated by perineural application of vinpocetine; also formalin-induced expression of c-fos in the ipsilateral, segmentally related superficial dorsal horn, was prevented by this treatment.	Formaldehyde	50-58	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	152-157
20648783-8	2010	Nociception, induced by intraplantar injection of formalin, was mitigated by perineural application of vinpocetine; also formalin-induced expression of c-fos in the ipsilateral, segmentally related superficial dorsal horn, was prevented by this treatment.	Formaldehyde	121-129	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	152-157
20347000-0	2010	Formaldehyde induces apoptosis through decreased Prx 2 via p38 MAPK in lung epithelial cells.	Formaldehyde	0-12	mitogen-activated protein kinase 14	Homo sapiens	59-62
20156467-7	2010	Immunohistochemical analysis found that the brain response to formalin injection was also more sensitive in middle-aged rats than young rats; a significant increase in the number of c-Fos immunoreactive cells was found in the ventral portion of the lateral septum of middle-aged rats injected with formalin compared to young and middle-aged rats injected with saline, irrespective of estrous cyclicity.	Formaldehyde	62-70	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	182-187
20304040-16	2010	EtOH, HEX and AcOEt (62.5-250 mg/kg) produced a significant antinociceptive effect in the formalin and capsaicin tests.	Formaldehyde	90-98	hematopoietically expressed homeobox	Mus musculus	6-9
20156467-7	2010	Immunohistochemical analysis found that the brain response to formalin injection was also more sensitive in middle-aged rats than young rats; a significant increase in the number of c-Fos immunoreactive cells was found in the ventral portion of the lateral septum of middle-aged rats injected with formalin compared to young and middle-aged rats injected with saline, irrespective of estrous cyclicity.	Formaldehyde	298-306	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	182-187
20090517-2	2010	A new monoclonal antibody, CON6D/B5, directed against the CD30 antigen has become commercially available for use in formalin-fixed paraffin-embedded tissue samples.	Formaldehyde	116-124	TNF receptor superfamily member 8	Homo sapiens	58-62
20048674-9	2010	There was excellent correlation in the distribution pattern of the 2 markers, although hCDC47 was more sensitive.Thus this marker may have important clinical and research applications because of its activity in formalin-fixed, paraffin-embedded, proliferating, normal, and neoplastic tissue.	Formaldehyde	211-219	minichromosome maintenance complex component 7	Homo sapiens	87-93
20592339-4	2010	In this study, the expression pattern of galectin-1 was determined in 73 formalin-fixed, paraffin-embedded vulvar tissues by a standard immunohistochemical method: 12 benign vulvar specimen, 41 vulvar intraepithelial lesions (VIN), according to their differentiation were subdivided into VIN I, II and III and 20 invasive squamous cell carcinomas (ISCC).	Formaldehyde	73-81	galectin 1	Homo sapiens	41-51
20459648-3	2010	The expressions of IDH1 and p53 in formalin-fixed paraffin-embedded tissue sections from 44 osteosarcoma patients were determined by immunohistochemistry, and the correlation between them and clinicopagthological features were analyzed.	Formaldehyde	35-43	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	19-23
20459648-3	2010	The expressions of IDH1 and p53 in formalin-fixed paraffin-embedded tissue sections from 44 osteosarcoma patients were determined by immunohistochemistry, and the correlation between them and clinicopagthological features were analyzed.	Formaldehyde	35-43	tumor protein p53	Homo sapiens	28-31
20395521-1	2010	The purpose of this pilot study was to determine the impact of the length of fixation in 10% buffered formalin on the expression of estrogen receptor by immunohistochemical analysis.	Formaldehyde	102-110	estrogen receptor 1	Homo sapiens	132-149
20395829-11	2010	Inhibition of EphBs receptors by intrathecal injection of EphB1-Fc reduced formalin-induced inflammation and chronic constrictive injury-induced neuropathic pain behaviors accompanied by decreased expression of spinal p-MAPKs and c-Fos protein.	Formaldehyde	75-83	EPH receptor B1	Homo sapiens	58-63
20477814-8	2010	The expression of AR and HSP 27 was stronger in formalin-injected tissue, while the opposite was true for HSP 60, HSP 70 and peroxiredoxin-2.	Formaldehyde	48-56	androgen receptor	Homo sapiens	18-20
20477814-8	2010	The expression of AR and HSP 27 was stronger in formalin-injected tissue, while the opposite was true for HSP 60, HSP 70 and peroxiredoxin-2.	Formaldehyde	48-56	heat shock protein family B (small) member 1	Homo sapiens	25-31
19786358-2	2010	We investigated the effects of bilateral intra-BLA administration of the CB1 receptor antagonist/inverse agonist, rimonabant, on formalin-evoked nociceptive behaviour, fear-conditioned behaviour including analgesia, and associated brain regional alterations in Fos expression in rats.	Formaldehyde	129-137	cannabinoid receptor 1	Rattus norvegicus	73-76
20426910-5	2010	The expression of Skp2 was examined by immunohistochemistry on formalin fixed, paraffin embedded tissue sections.	Formaldehyde	63-71	S-phase kinase associated protein 2	Homo sapiens	18-22
19900756-4	2010	Further comparisons of formalin-fixed paraffin-embedded human choriocarcinoma, mole, and non-cancer trophoblast tissues confirmed the initial findings of low miR-199b expression and SET upregulation in choriocarcinomas, suggesting that microRNA-dysregulated SET protein may account for the rapid growth seen with choriocarcinomas.	Formaldehyde	23-31	microRNA 199b	Homo sapiens	158-166
19786358-5	2010	Formalin-evoked nociceptive behaviour was associated with increased Fos immunoreactivity (FI) in the CA2/3 region of the hippocampus and rostral ventromedial medulla, effects attenuated by intra-BLA rimonabant.	Formaldehyde	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	68-71
19786358-5	2010	Formalin-evoked nociceptive behaviour was associated with increased Fos immunoreactivity (FI) in the CA2/3 region of the hippocampus and rostral ventromedial medulla, effects attenuated by intra-BLA rimonabant.	Formaldehyde	0-8	carbonic anhydrase 3	Rattus norvegicus	101-106
19800272-6	2010	The diminished acute nocifensive and heat threshold-lowering effects of resiniferatoxin or N-oleoyldopamine by pretreatment with doses that failed to elevate the heat threshold and to alter the nocifensive action of the TRPA1 activator formaldehyde, were taken as indication of TRPV1 receptor desensitization.	Formaldehyde	236-248	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	220-225
20530420-2	2010	MATERIALS AND METHODS: The immunohistochemical expression of HIF1alpha was studied in formalin-fixed paraffin-embedded tissues from 60 patients who had undergone thoracic surgery for lung cancer (n=48) or pneumothorax (n=12) under OLV general anesthesia.	Formaldehyde	86-94	hypoxia inducible factor 1 subunit alpha	Homo sapiens	61-70
20304943-8	2010	Determination of PITX2 methylation in formalin-fixed and paraffin-embedded tissue samples from a cohort of 157 prostatectomy patients resulted in an excellent level of concordance of the clinical classification, as well as the measured output between the research assay and the Epichip PITX2.	Formaldehyde	38-46	paired like homeodomain 2	Homo sapiens	17-22
20422007-5	2010	The present study aims to demonstrate that the tumor tissue-derived endogenous formaldehyde induces bone cancer pain via TRPV1 activation under tumor acidic environment.	Formaldehyde	79-91	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	121-126
20422007-7	2010	Low concentrations (1 approximately 5 mM) of formaldehyde induced pain responses in rat via TRPV1 and this pain response could be significantly enhanced by pH 6.0 (mimicking the acidic tumor microenvironment).	Formaldehyde	45-57	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	92-97
20422007-8	2010	Formaldehyde at low concentrations (1 mM to 100 mM) induced a concentration-dependent increase of [Ca(2+)]i in the freshly isolated rat dorsal root ganglion neurons and TRPV1-transfected CHO cells.	Formaldehyde	0-12	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	169-174
20422007-9	2010	Furthermore, electrophysiological experiments showed that low concentration formaldehyde-elicited TRPV1 currents could be significantly potentiated by low pH (6.0).	Formaldehyde	76-88	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	98-103
20422007-11	2010	CONCLUSIONS/SIGNIFICANCE: Our data suggest that cancer tissues directly secrete endogenous formaldehyde, and this formaldehyde at low concentration induces metastatic bone cancer pain through TRPV1 activation especially under tumor acidic environment.	Formaldehyde	91-103	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	192-197
20422007-11	2010	CONCLUSIONS/SIGNIFICANCE: Our data suggest that cancer tissues directly secrete endogenous formaldehyde, and this formaldehyde at low concentration induces metastatic bone cancer pain through TRPV1 activation especially under tumor acidic environment.	Formaldehyde	114-126	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	192-197
20210847-7	2010	Blockade of NK(1) and NK(2) receptors attenuated the formalin-induced increases in mean arterial pressure and heart rate, adrenaline and ACTH concentrations in plasma, and completely abolished the pain-induced c-Fos expression in corticotrophin-releasing hormone neurones localised in the parvocellular division of the PVN.	Formaldehyde	53-61	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	210-215
20171959-7	2010	Pain behavioural evaluation using the formalin test showed that Ang II injection into the CVLM induced hyperalgesia, which was partially prevented by lesion of the A(5) noradrenergic cell group with anti-DBH-SAP.	Formaldehyde	38-46	angiotensinogen	Homo sapiens	64-70
20030632-8	2010	On day 1 after the exposure to formalin, Ca(v)1.2c currents were increased, 2.1 and 2.2 currents were decreased and 2.3 currents were unaltered.	Formaldehyde	31-39	calcium channel, voltage-dependent, L type, alpha 1C subunit S homeolog	Xenopus laevis	41-49
20356418-5	2010	METHODS: In formalin-fixed tissues, the expression level of GalNAc-T14 protein was evaluated by immunohistochemistry assay in breast tissues.	Formaldehyde	12-20	polypeptide N-acetylgalactosaminyltransferase 14	Homo sapiens	60-70
20367313-10	2010	CONCLUSIONS: A multiplex polymerase chain reaction-based amplification followed by dideoxy-termination sequencing may be used advantageously for the evaluation of KRas and BRaf mutational status from formalin-fixed, paraffin-embedded samples.	Formaldehyde	200-208	KRAS proto-oncogene, GTPase	Homo sapiens	163-167
20367313-10	2010	CONCLUSIONS: A multiplex polymerase chain reaction-based amplification followed by dideoxy-termination sequencing may be used advantageously for the evaluation of KRas and BRaf mutational status from formalin-fixed, paraffin-embedded samples.	Formaldehyde	200-208	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	172-176
20156214-7	2010	Immunohistochemical analysis of formalin-fixed paraffin-embedded (FFPE) breast cancer tissues revealed higher TLR9 protein expression in hormone-receptor (HR)-negative specimens (n = 116, P &lt; 0.001).	Formaldehyde	32-40	toll like receptor 9	Homo sapiens	110-114
20448356-4	2010	RESULTS: Compared with the control group, the expression of Fas mRNA and its protein and caspase-8 mRNA and the activity of caspase-8 and caspase-3 of ovary tissues in the rats treated with formaldehyde significantly increased with dose (P&lt;0.05).	Formaldehyde	190-202	caspase 8	Rattus norvegicus	89-98
20207772-6	2010	RESULTS: The digital array detected and quantified rare gefitinib/erlotinib-sensitizing EGFR mutations (0.02%-9.26% abundance) that were present in formalin-fixed, paraffin-embedded samples of early-stage resectable lung tumors without an associated increase in gene copy number.	Formaldehyde	148-156	epidermal growth factor receptor	Homo sapiens	88-92
20375793-3	2010	METHODS: The expression of endothelial nitric oxide synthase was tested in formalin-fixed, paraffin-embedded tissues from specimens including 8 first trimester placentas, 3 partial hydatidiform moles, 20 complete hydatidiform moles, 2 invasive moles, and 5 choriocarcinomas.	Formaldehyde	75-83	nitric oxide synthase 3	Homo sapiens	27-60
20025955-3	2010	Specifically, semicarbazide-sensitive amine oxidase of differentiated 3T3-L1 cells was found to utilize methylamine for producing formaldehyde and hydrogen peroxide, accounting for the inhibition of infectivity of Toxoplasma gondii and its replication in these cells.	Formaldehyde	130-142	amine oxidase, copper containing 3	Mus musculus	14-51
20448356-1	2010	OBJECTIVE: To explore the mechanism of formaldehyde inducing ovarian toxicity in female rats by observing the effect of formaldehyde on the expression of Fas and caspase-8 mRNA, and the activity of caspase-3 and caspase-8 of ovary tissues in female rats.	Formaldehyde	39-51	caspase 8	Rattus norvegicus	162-171
20448356-1	2010	OBJECTIVE: To explore the mechanism of formaldehyde inducing ovarian toxicity in female rats by observing the effect of formaldehyde on the expression of Fas and caspase-8 mRNA, and the activity of caspase-3 and caspase-8 of ovary tissues in female rats.	Formaldehyde	39-51	caspase 3	Rattus norvegicus	198-207
20448356-1	2010	OBJECTIVE: To explore the mechanism of formaldehyde inducing ovarian toxicity in female rats by observing the effect of formaldehyde on the expression of Fas and caspase-8 mRNA, and the activity of caspase-3 and caspase-8 of ovary tissues in female rats.	Formaldehyde	39-51	caspase 8	Rattus norvegicus	212-221
20448356-1	2010	OBJECTIVE: To explore the mechanism of formaldehyde inducing ovarian toxicity in female rats by observing the effect of formaldehyde on the expression of Fas and caspase-8 mRNA, and the activity of caspase-3 and caspase-8 of ovary tissues in female rats.	Formaldehyde	120-132	caspase 8	Rattus norvegicus	162-171
20448356-4	2010	RESULTS: Compared with the control group, the expression of Fas mRNA and its protein and caspase-8 mRNA and the activity of caspase-8 and caspase-3 of ovary tissues in the rats treated with formaldehyde significantly increased with dose (P&lt;0.05).	Formaldehyde	190-202	caspase 8	Rattus norvegicus	124-133
20448356-4	2010	RESULTS: Compared with the control group, the expression of Fas mRNA and its protein and caspase-8 mRNA and the activity of caspase-8 and caspase-3 of ovary tissues in the rats treated with formaldehyde significantly increased with dose (P&lt;0.05).	Formaldehyde	190-202	caspase 3	Rattus norvegicus	138-147
20448356-5	2010	CONCLUSION: The increase of Fas gene expression and the activity of caspase-8 and caspase-3 may be the important mechanism of ovarian toxicity induced by formaldehyde in female rats.	Formaldehyde	154-166	caspase 8	Rattus norvegicus	68-77
20448356-5	2010	CONCLUSION: The increase of Fas gene expression and the activity of caspase-8 and caspase-3 may be the important mechanism of ovarian toxicity induced by formaldehyde in female rats.	Formaldehyde	154-166	caspase 3	Rattus norvegicus	82-91
20026253-3	2010	Immunohistochemical double-labeling technique with Fos was used to examine if an intraplantar formalin injection, an acute noxious input, changed the effect of morphine on dopaminergic neurons of the ventral tegmental area (VTA), and serotonergic neurons of the dorsal raphe nucleus (DR).	Formaldehyde	94-102	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	51-54
20302612-3	2010	METHODS: First, rats subjected to either a supramaximal electrical stimulation or an injection of high-dose formalin in the hind limb were identified to have pain responses with behavioral evidence and spinal Fos-immunoreactive profiles.	Formaldehyde	108-116	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	209-212
20026253-7	2010	In contrast, the number of serotonergic neurons containing Fos was increased in the morphine/formalin group compared to all other groups and this effect was topographically selective for the dorsal area of the DR at mid rostro-caudal levels.	Formaldehyde	93-101	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	59-62
20035838-9	2010	Indeed, NTS2 knockout mice submitted to both acute (plantar test) and tonic (formalin test) pain stimuli show a greater sensitivity to pain in comparison to wild-type littermates.	Formaldehyde	77-85	nuclear encoded tRNA selenocysteine 2 (anticodon TCA)	Mus musculus	8-12
20136846-10	2010	TRPV4 gene knockdown or deletion also markedly reduced oedema and granulocyte infiltration induced by intraplantar injection of formalin.	Formaldehyde	128-136	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	0-5
20393008-4	2010	MATERIALS AND METHODS: SPARC mRNA expression was evaluated in 104 formalin-fixed paraffin-embedded tissue samples of pancreatic adenocarcinoma patients with macro-dissection technique.	Formaldehyde	66-74	secreted protein acidic and cysteine rich	Homo sapiens	23-28
20237269-9	2010	In addition, Ret-Na(v)1.8 CKO mice have increased sensitivity to cold and increased formalin-induced pain, demonstrating that Ret signaling modulates the function of nociceptors in vivo.	Formaldehyde	84-92	ret proto-oncogene	Mus musculus	13-16
20237269-9	2010	In addition, Ret-Na(v)1.8 CKO mice have increased sensitivity to cold and increased formalin-induced pain, demonstrating that Ret signaling modulates the function of nociceptors in vivo.	Formaldehyde	84-92	ret proto-oncogene	Mus musculus	126-129
20148560-2	2010	LSD1 belongs to the amine oxidase enzyme superfamily which utilize molecular oxygen to transform amines to imines that are hydrolytically cleaved to formaldehyde.	Formaldehyde	149-161	lysine demethylase 1A	Homo sapiens	0-4
19725829-2	2010	In the present study, we have found oligomeric Abeta to be associated with both diffuse and neuritic plaques (mostly co-localized with Abeta(1-42)) and with cerebrovascular deposits of Abeta in paraffin sections of formalin-fixed human brain tissue.	Formaldehyde	215-223	amyloid beta precursor protein	Homo sapiens	47-52
20056739-4	2010	RESULTS: The RT-PCR assay is applicable for detecting the various described fusion transcripts of PAX8/PPARG in formalin-fixed, paraffin-embedded thyroid tissue and in fine-needle aspirate biopsy washes from thyroid nodules.	Formaldehyde	112-120	paired box 8	Homo sapiens	98-102
20056739-4	2010	RESULTS: The RT-PCR assay is applicable for detecting the various described fusion transcripts of PAX8/PPARG in formalin-fixed, paraffin-embedded thyroid tissue and in fine-needle aspirate biopsy washes from thyroid nodules.	Formaldehyde	112-120	peroxisome proliferator activated receptor gamma	Homo sapiens	103-108
19525133-4	2010	In this study, a noxious injection of formalin was given into the lower lip of female rats, thereby activating nociceptive neurons in the trigeminal subnucleus caudalis as demonstrated by immunohistochemical labeling of Fos.	Formaldehyde	38-46	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	220-223
20060709-5	2010	Trop-2 protein expression was then examined by immunohistochemistry in matched formalin-fixed paraffin-embedded EOC samples and in 13 normal ovaries.	Formaldehyde	79-87	tumor associated calcium signal transducer 2	Homo sapiens	0-6
20081804-2	2010	In this study, we evaluated sphingosine-1-phosphate receptor 1"s suitability as a diagnostic marker for malignant lymphoma by immunostaining formalin-fixed paraffin-embedded sections using a well-defined commercial anti-sphingosine-1-phosphate receptor 1 antibody.	Formaldehyde	141-149	sphingosine-1-phosphate receptor 1	Homo sapiens	28-62
20379448-3	2010	METHODS: Immunohistochemical staining of syndecan-1 was performed in 101 formalin fixed, paraffin embedded sections of normal, hyperplastic, and malignant endometrial tissues.	Formaldehyde	73-81	syndecan 1	Homo sapiens	41-51
19945538-1	2010	INTRODUCTION: The use of antibodies to proliferating cell nuclear antigen (PCNA) for the immunohistochemical detection of proliferating cells has been limited in frozen tissue sections because of its temperature dependence and instability in formaldehyde.	Formaldehyde	242-254	proliferating cell nuclear antigen	Mus musculus	39-73
19945538-1	2010	INTRODUCTION: The use of antibodies to proliferating cell nuclear antigen (PCNA) for the immunohistochemical detection of proliferating cells has been limited in frozen tissue sections because of its temperature dependence and instability in formaldehyde.	Formaldehyde	242-254	proliferating cell nuclear antigen	Mus musculus	75-79
20081804-11	2010	Thus, sphingosine-1-phosphate receptor 1 immunohistochemistry may be useful in the histological diagnosis of mantle cell lymphoma with formalin-fixed and paraffin-embedded sections.	Formaldehyde	135-143	sphingosine-1-phosphate receptor 1	Homo sapiens	6-40
20093389-0	2010	Mutation detection of epidermal growth factor receptor and KRAS genes using the smart amplification process version 2 from formalin-fixed, paraffin-embedded lung cancer tissue.	Formaldehyde	123-131	epidermal growth factor receptor	Homo sapiens	22-54
20093389-0	2010	Mutation detection of epidermal growth factor receptor and KRAS genes using the smart amplification process version 2 from formalin-fixed, paraffin-embedded lung cancer tissue.	Formaldehyde	123-131	KRAS proto-oncogene, GTPase	Homo sapiens	59-63
20190607-0	2010	Correspondence regarding: diagnostic utility of IDH1/2 mutation analysis in routine clinical testing of formalin-fixed paraffin-embedded glioma tissues.	Formaldehyde	104-112	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	48-52
20106595-5	2010	In contrast, intrathalamic administration of [D-Ala(2), N-Me-Phe(4), Gly(5)-ol]-enkephalin acetate (DAMGO), a MOR-specific agonist, induced a statistically significant decrease of all tonic phase pain-related behaviours assessed until 30-35min after formalin hind paw injection.	Formaldehyde	250-258	proenkephalin	Rattus norvegicus	80-90
20172376-6	2010	Formalin-fixed, paraffin-embedded tissues from the 92 patients were immunohistochemically stained for cyclin D1, cyclin E, p27(kip1), and p57(kip2), and protein expression levels were quantified and compared among the groups.	Formaldehyde	0-8	cyclin dependent kinase inhibitor 1C	Homo sapiens	142-146
19963048-4	2010	Herein, evidences for a role of ADH3 in cell signaling through thiol homeostasis is highlighted, underscoring that the enzyme functions more broadly than to metabolize formaldehyde.	Formaldehyde	168-180	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	32-36
20450759-2	2010	METHODS: Immunohistochemical study for CD34 was performed on formalin-fixed paraffin-embedded tissue blocks of 54 cases of brain tumors occurring in patients with refractory epilepsy.	Formaldehyde	61-69	CD34 molecule	Homo sapiens	39-43
20091050-6	2010	Formalin-fixed paraffin embedded pancreatic tissue was immunostained for ILK, E-cadherin, N-cadherin, and Snail by standard techniques.	Formaldehyde	0-8	integrin linked kinase	Homo sapiens	73-76
20091050-6	2010	Formalin-fixed paraffin embedded pancreatic tissue was immunostained for ILK, E-cadherin, N-cadherin, and Snail by standard techniques.	Formaldehyde	0-8	cadherin 1	Homo sapiens	78-88
20005040-2	2010	As macrophage migration inhibitory factor (MIF), a pleiotropic cytokine produced mainly by nonneuronal tissue, has been involved in the regulation of neuronal functions, herein we examined the role for MIF in formalin-induced inflammatory pain model.	Formaldehyde	209-217	macrophage migration inhibitory factor	Rattus norvegicus	3-41
20149257-9	2010	Studies using additional strains of mice confirmed that spinal cord mRNA expression levels of Mapk8 followed the pattern predicted by strain-specific levels of formalin behavior.	Formaldehyde	160-168	mitogen-activated protein kinase 8	Mus musculus	94-99
20149257-14	2010	Comparing formalin late phase behavior levels with spinal cord gene expression yielded several plausible gene candidates, including the Mapk8 gene.	Formaldehyde	10-18	mitogen-activated protein kinase 8	Mus musculus	136-141
20097833-3	2010	DESIGN/METHOD: We used monoclonal anti-EpCAM antibody Ber-Ep4 for immunohistochemistry on formalin-fixed and paraffin-embedded tumor material.	Formaldehyde	90-98	epithelial cell adhesion molecule	Homo sapiens	39-44
19614992-4	2010	METHODS: We used a commercially available antibody to K75 on formalin-fixed, paraffin-embedded tissue from clinically and histologically "normal" scalp (n=9); clinically diseased scalp from patients with CCCA (n=15); and clinically "normal" scalp from patients with CCCA (n=6).	Formaldehyde	61-69	keratin 75	Homo sapiens	54-57
20005040-3	2010	MIF critically contributed to nociceptive behaviors following formalin injection.	Formaldehyde	62-70	macrophage migration inhibitory factor	Rattus norvegicus	0-3
20005040-5	2010	Further examination showed that levels of both MIF and the MIF receptor CD74 were substantially increased within the ipsilateral spinal cord dorsal horn after formalin administration.	Formaldehyde	159-167	macrophage migration inhibitory factor	Rattus norvegicus	47-50
20005040-5	2010	Further examination showed that levels of both MIF and the MIF receptor CD74 were substantially increased within the ipsilateral spinal cord dorsal horn after formalin administration.	Formaldehyde	159-167	macrophage migration inhibitory factor	Rattus norvegicus	59-62
20005040-5	2010	Further examination showed that levels of both MIF and the MIF receptor CD74 were substantially increased within the ipsilateral spinal cord dorsal horn after formalin administration.	Formaldehyde	159-167	CD74 molecule	Rattus norvegicus	72-76
20005040-7	2010	Moreover, microglial cells were found to be the major source of spinal MIF after formalin administration by fluorescence colocalization.	Formaldehyde	81-89	macrophage migration inhibitory factor	Rattus norvegicus	71-74
20134266-6	2010	METHODS: Hypoxia-inducible protein 2 expression was analyzed by immunohistochemistry in formalin-fixed surgical samples from 254 EOC, 17 endometrial, and 29 renal CCC patients.	Formaldehyde	88-96	hypoxia inducible lipid droplet associated	Homo sapiens	9-36
20005040-2	2010	As macrophage migration inhibitory factor (MIF), a pleiotropic cytokine produced mainly by nonneuronal tissue, has been involved in the regulation of neuronal functions, herein we examined the role for MIF in formalin-induced inflammatory pain model.	Formaldehyde	209-217	macrophage migration inhibitory factor	Rattus norvegicus	202-205
20005040-8	2010	These data highlight spinal MIF plays a critical role in the pathogenesis of formalin-induced inflammatory pain and suggest MIF may be a potential target for therapy of such pathological condition.	Formaldehyde	77-85	macrophage migration inhibitory factor	Rattus norvegicus	28-31
20126411-4	2010	METHODS AND FINDINGS: Using archival formalin-fixed paraffin embedded (FFPE) extracted genomic DNA, we show that c-CBL mutations occur in somatic fashion for lung cancers.	Formaldehyde	37-45	Cbl proto-oncogene	Homo sapiens	113-118
19833107-5	2010	However, the percentage of noradrenergic neurons in the A7 and A5 cell groups that contained Fos was significantly increased in the morphine/formalin group compared to all other groups, while no differences were found in serotonin cells in the NRM.	Formaldehyde	141-149	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	93-96
19837141-11	2010	These results suggest that peripheral activation of the 5-HT(1A,) 5-HT(1B), 5-HT(1D), 5-HT(1F) and, probably, 5-HT(1E) receptor subtypes leads to antinociception in the rat formalin test.	Formaldehyde	173-181	5-hydroxytryptamine receptor 1A	Rattus norvegicus	56-73
19837141-11	2010	These results suggest that peripheral activation of the 5-HT(1A,) 5-HT(1B), 5-HT(1D), 5-HT(1F) and, probably, 5-HT(1E) receptor subtypes leads to antinociception in the rat formalin test.	Formaldehyde	173-181	5-hydroxytryptamine receptor 1D	Rattus norvegicus	76-83
19837141-11	2010	These results suggest that peripheral activation of the 5-HT(1A,) 5-HT(1B), 5-HT(1D), 5-HT(1F) and, probably, 5-HT(1E) receptor subtypes leads to antinociception in the rat formalin test.	Formaldehyde	173-181	5-hydroxytryptamine receptor 1F	Rattus norvegicus	86-93
19874873-4	2010	A similar increase in the number of flinches during the second phase of the response to formalin also occurred in the contralateral paw 24 h after ET-1.	Formaldehyde	88-96	endothelin 1	Rattus norvegicus	147-151
19741063-5	2010	Additionally, the SP-A expression pattern was evaluated by immunohistochemistry in formalin-fixed, paraffin-embedded lung tissue sections from the same subjects.	Formaldehyde	83-91	surfactant protein A1	Homo sapiens	18-22
19898228-3	2010	We retrospectively evaluated 100 consecutive formalin-fixed PSC liver explants (including 30 with CCA) by randomly sampling the hilar and large intrahepatic bile ducts (10 additional tissue cassettes submitted per case).	Formaldehyde	45-53	PSC	Homo sapiens	60-63
21092257-3	2010	The methylation status of CST6 gene encoding cystatin M was evaluated using methylation-specific polymerase chain reaction (PCR) in formalin-fixed paraffin-embedded tissues from 292 participants and using pyrosequencing in fresh-frozen tumor and matched normal tissues from 51 IBC patients.	Formaldehyde	132-140	cystatin E/M	Homo sapiens	26-30
21092257-3	2010	The methylation status of CST6 gene encoding cystatin M was evaluated using methylation-specific polymerase chain reaction (PCR) in formalin-fixed paraffin-embedded tissues from 292 participants and using pyrosequencing in fresh-frozen tumor and matched normal tissues from 51 IBC patients.	Formaldehyde	132-140	cystatin E/M	Homo sapiens	45-55
19004480-5	2010	The immunolocalisation of cofilin was studied by immunohistochemistry in 34 formalin-fixed, paraffin wax-embedded gastrointestinal endocrine cell tumors using a tissue microarray platform.	Formaldehyde	76-84	cofilin 1	Homo sapiens	26-33
22012771-3	2010	MATERIALS AND METHODS: An immunohistochemical study was performed using rabbit monoclonal antibody to iNOS on archival formalin fixed, paraffin embedded tissues of 5 normal oral mucosal samples, 10 Leukoplakia, 10 oral submucous fibrosis (OSMF) and 15 OSCC of different grades.	Formaldehyde	119-127	nitric oxide synthase 2	Homo sapiens	102-106
22072121-4	2010	For this first Tunisian study on KRAS, we detected 45.83% of altered KRAS gene among 48 formalin-fixed paraffin-embedded sporadic colorectal adenocarcinoma patients.	Formaldehyde	88-96	KRAS proto-oncogene, GTPase	Homo sapiens	33-37
22072121-4	2010	For this first Tunisian study on KRAS, we detected 45.83% of altered KRAS gene among 48 formalin-fixed paraffin-embedded sporadic colorectal adenocarcinoma patients.	Formaldehyde	88-96	KRAS proto-oncogene, GTPase	Homo sapiens	69-73
19318283-9	2010	), the CB2 receptor-selective antagonist, only prevented it in the paw formalin test.	Formaldehyde	71-79	cannabinoid receptor 2	Homo sapiens	7-10
19882219-6	2010	This finding was validated by immunohistochemical staining of Ki67 and Cyclin D1 in Formalin-Fixed Paraffin-Embedded (FFPE) section of the same samples, and in an independent cohort of FFPE matched tumor and metastatic tissue samples.	Formaldehyde	84-92	cyclin D1	Homo sapiens	71-80
22615590-0	2010	Formalin pain increases the concentration of serotonin and its 5-hydroxyindoleacetic acid metabolite in the CA1 region of hippocampus.	Formaldehyde	0-8	carbonic anhydrase 1	Rattus norvegicus	108-111
20010306-3	2010	Mutation analysis of TP53 Exons 4 to 9 on DNA from formalin-fixed, paraffin-embedded specimens was performed by bidirectional DNA sequencing.	Formaldehyde	51-59	tumor protein p53	Homo sapiens	21-25
21197450-3	2010	We examined KRAS mutations in exon 2 codons 12 and 13 with DNA sequencing and SNaPshot analysis in 100 formalin-fixed paraffin-embedded tumor tissue samples of pancreatic carcinoma, colorectal carcinoma, and nonsmall cell lung cancer specimens of the primary tumor or metastases.	Formaldehyde	103-111	KRAS proto-oncogene, GTPase	Homo sapiens	12-16
19956839-9	2010	Anti-PP-mTOR(Ser2481)-labeled mitotic figures (MFs) were easily seen and permitted a quick identification of mitotic hotspots in formalin-fixed cancer tissues, even at low magnification.	Formaldehyde	129-137	mechanistic target of rapamycin kinase	Homo sapiens	8-12
20634879-0	2010	Optimization of formaldehyde cross-linking for protein interaction analysis of non-tagged integrin beta1.	Formaldehyde	16-28	integrin subunit beta 1	Homo sapiens	90-104
20634879-2	2010	Here we used integrin beta1 as a model to describe the application of formaldehyde cross-linking in detail, particularly focusing on the optimal parameters for cross-linking, the detection of formaldehyde cross-linked complexes, the utility of antibodies, and the identification of binding partners.	Formaldehyde	70-82	integrin subunit beta 1	Homo sapiens	13-27
20634879-3	2010	Integrin beta1 was found in a high molecular weight complex after formaldehyde cross-linking.	Formaldehyde	66-78	integrin subunit beta 1	Homo sapiens	0-14
20634879-6	2010	Formaldehyde cross-linked complexes, precipitated from Jurkat cells or human platelets and analyzed by mass spectrometry, were found to be composed of integrin beta1, alpha4 and alpha6 or beta1, alpha6, alpha2, and alpha5, respectively.	Formaldehyde	0-12	integrin subunit beta 1	Homo sapiens	151-165
20634879-6	2010	Formaldehyde cross-linked complexes, precipitated from Jurkat cells or human platelets and analyzed by mass spectrometry, were found to be composed of integrin beta1, alpha4 and alpha6 or beta1, alpha6, alpha2, and alpha5, respectively.	Formaldehyde	0-12	immunoglobulin binding protein 1	Homo sapiens	167-201
19959798-4	2010	Here, we describe a two-step KRAS mutation screening protocol that combines whole-genome amplification (WGA), high-resolution melting analysis (HRM) as a prescreen method for mutation carrying samples, and direct Sanger sequencing of DNA from formalin-fixed, paraffin-embedded (FFPE) tissue, from which limited amounts of DNA are available.	Formaldehyde	243-251	KRAS proto-oncogene, GTPase	Homo sapiens	29-33
19959799-0	2010	Detection of BRCA1 and BRCA2 Ashkenazi Jewish founder mutations in formalin-fixed paraffin-embedded tissues using conventional PCR and heteroduplex/amplicon size differences.	Formaldehyde	67-75	BRCA1 DNA repair associated	Homo sapiens	13-18
19959799-0	2010	Detection of BRCA1 and BRCA2 Ashkenazi Jewish founder mutations in formalin-fixed paraffin-embedded tissues using conventional PCR and heteroduplex/amplicon size differences.	Formaldehyde	67-75	BRCA2 DNA repair associated	Homo sapiens	23-28
19828879-2	2010	We have previously demonstrated that DAO gene deletion/mutation by using mutant ddY/DAO(-/-) mice and systemic administration of the DAO inhibitor sodium benzoate blocked formalin-induced hyperalgesia in mice.	Formaldehyde	171-179	D-amino acid oxidase	Mus musculus	37-40
19895170-3	2010	We have shown, that application of nested two-stage methylation-specific PCR (MSP) is asuitable method for analysis of epigenetically silenced GSTP1 in formalin-fixed paraffin-embedded (FFPE) tissues from breast cancer patients.	Formaldehyde	152-160	glutathione S-transferase pi 1	Homo sapiens	143-148
20881409-1	2010	OBJECTIVE: Our aims were to measure the level of expression of Abelson (ABL1), beta-glucuronidase (GUS) and glucose-6-phosphate dehydrogenase (G6PD) genes in exfoliated urine cells from healthy and transrectal ultrasound biopsy patients with elevated prostate-specific antigen levels and/or abnormal digital rectal examinations or urinary symptoms indicative of prostate problems, as well as in archived formalin-fixed paraffin-embedded prostate materials.	Formaldehyde	404-412	glucose-6-phosphate dehydrogenase	Homo sapiens	143-147
20169940-0	2010	[Comparison of two HER-2 FISH kits on formalin-fixed paraffin-embedded tissues: signal detection and simple procedure].	Formaldehyde	38-46	erb-b2 receptor tyrosine kinase 2	Homo sapiens	19-24
20568899-2	2010	We measured expression of Fcer2, Pdl2 and Blk genes using real-time quantitative polymerase chain reaction (RTqPCR) on formalin fixed, paraffin embedded material (FFPE) and suggested a formula to discriminate PMBL from DLBCL.	Formaldehyde	119-127	Fc epsilon receptor II	Homo sapiens	26-31
20568899-2	2010	We measured expression of Fcer2, Pdl2 and Blk genes using real-time quantitative polymerase chain reaction (RTqPCR) on formalin fixed, paraffin embedded material (FFPE) and suggested a formula to discriminate PMBL from DLBCL.	Formaldehyde	119-127	BLK proto-oncogene, Src family tyrosine kinase	Homo sapiens	42-45
22163450-0	2010	A potentiometric formaldehyde biosensor based on immobilization of alcohol oxidase on acryloxysuccinimide-modified acrylic microspheres.	Formaldehyde	17-29	acyl-CoA oxidase 1	Homo sapiens	67-82
22163450-1	2010	A new alcohol oxidase (AOX) enzyme-based formaldehyde biosensor based on acrylic microspheres has been developed.	Formaldehyde	41-53	acyl-CoA oxidase 1	Homo sapiens	6-21
22163450-1	2010	A new alcohol oxidase (AOX) enzyme-based formaldehyde biosensor based on acrylic microspheres has been developed.	Formaldehyde	41-53	acyl-CoA oxidase 1	Homo sapiens	23-26
22163450-4	2010	Oxidation of formaldehyde by the immobilized AOX resulted in the production of protons, which can be determined via the pH transducer.	Formaldehyde	13-25	acyl-CoA oxidase 1	Homo sapiens	45-48
20120772-2	2009	METHODS: PDCD5 expression was determined by EnVision immunohistochemical staining in formalin-fixed and paraffin-embedded specimens obtained from 12 subjects with NP, 22 with BPH, and 22 with PCa.	Formaldehyde	85-93	programmed cell death 5	Homo sapiens	9-14
19782054-9	2009	injection of formalin (1%) produced significantly fewer nocifensive behaviors and expression of c-Fos protein in the spinal dorsal horn, confirming the hypoalgesic status in the inflamed site.	Formaldehyde	13-21	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	96-101
19104930-5	2009	In this study we have investigated the usefulness of several antibodies generated to specific phosphorylated sites within ERalpha for immunohistochemistry of formalin-fixed, paraffin-embedded human breast cancer biopsy samples.	Formaldehyde	158-166	estrogen receptor 1	Homo sapiens	122-129
19930704-2	2009	METHODS: The expressions of P-gp, LRP and MRP in formalin-fixed paraffin-embedded tissue sections from 59 gastric cancer patients were determined by a labbelled Streptavidin-Peroxidase (SP) immunohistochemical technique, and the results were analyzed in correlation with clinicopathological data.	Formaldehyde	49-57	ATP binding cassette subfamily B member 1	Homo sapiens	28-32
19675076-0	2009	Estrogen receptor 1 mRNA is a prognostic factor in ovarian carcinoma: determination by kinetic PCR in formalin-fixed paraffin-embedded tissue.	Formaldehyde	102-110	estrogen receptor 1	Homo sapiens	0-19
19675076-3	2009	Therefore, we tested if ER expression analysis by a quantitative method might be useful in this regard in formalin-fixed paraffin-embedded (FFPE) tissue.	Formaldehyde	106-114	estrogen receptor 1	Homo sapiens	24-26
20209972-12	2009	Comparison of the phosphorylated NR 2 B among 5 groups showed that EA-ST 32 and EA-LI 4-PC 6 could effectively down-regulate 2.5% formaldehyde induced increase of NR 2 B phosphorylation levels (P&lt;0.05), while EA-ST 36-GB 34 had no obvious effect on it (P&gt;0.05).	Formaldehyde	130-142	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	33-39
20209972-12	2009	Comparison of the phosphorylated NR 2 B among 5 groups showed that EA-ST 32 and EA-LI 4-PC 6 could effectively down-regulate 2.5% formaldehyde induced increase of NR 2 B phosphorylation levels (P&lt;0.05), while EA-ST 36-GB 34 had no obvious effect on it (P&gt;0.05).	Formaldehyde	130-142	proprotein convertase subtilisin/kexin type 5	Rattus norvegicus	88-92
20209972-12	2009	Comparison of the phosphorylated NR 2 B among 5 groups showed that EA-ST 32 and EA-LI 4-PC 6 could effectively down-regulate 2.5% formaldehyde induced increase of NR 2 B phosphorylation levels (P&lt;0.05), while EA-ST 36-GB 34 had no obvious effect on it (P&gt;0.05).	Formaldehyde	130-142	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	163-169
20055873-3	2009	HIF-1alpha expression was assessed by immunohistochemistry in formalin-fixed, paraffin wax-embedded tumour sections.	Formaldehyde	62-70	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
19861894-8	2009	Formalin-fixed paraffin-embedded (FFPE) tissue was tested for UGT1A1 promoter variants by polymerase chain reaction and capillary electrophoresis.	Formaldehyde	0-8	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	62-68
19861894-9	2009	To our knowledge, this is the first study to successfully apply UGT1A1 promoter genotyping to formalin-fixed paraffin-embedded tissue, which may facilitate more thorough examination of clinicopathologic correlations.	Formaldehyde	94-102	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	64-70
19915484-3	2009	We describe a simple and accurate molecular assay for detection of IDH1/2 mutations on routine formalin-fixed paraffin-embedded tissues.	Formaldehyde	95-103	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	67-73
19911196-0	2009	Vascular endothelial growth factor C mRNA expression is a prognostic factor in epithelial ovarian cancer as detected by kinetic RT-PCR in formalin-fixed paraffin-embedded tissue.	Formaldehyde	138-146	vascular endothelial growth factor C	Homo sapiens	0-36
19930704-2	2009	METHODS: The expressions of P-gp, LRP and MRP in formalin-fixed paraffin-embedded tissue sections from 59 gastric cancer patients were determined by a labbelled Streptavidin-Peroxidase (SP) immunohistochemical technique, and the results were analyzed in correlation with clinicopathological data.	Formaldehyde	49-57	ATP binding cassette subfamily C member 3	Homo sapiens	42-45
19734848-1	2009	Delay to formalin fixation may invalidate hormone receptors and HER2 analyses.	Formaldehyde	9-17	erb-b2 receptor tyrosine kinase 2	Homo sapiens	64-68
19695681-4	2009	In this study, we determined the methylation frequency of 5 genes, including p16, Runx3, MGMT, DAPK, and RASSF1A, by methylation-specific polymerase chain reaction, in a series of formalin-fixed paraffin-embedded tissues including normal gastric mucosa (n = 20), intestinal metaplasia (n = 14), gastric epithelial dysplasia (n = 27), and early gastric adenocarcinoma (n = 16).	Formaldehyde	180-188	cyclin dependent kinase inhibitor 2A	Homo sapiens	77-80
19695681-4	2009	In this study, we determined the methylation frequency of 5 genes, including p16, Runx3, MGMT, DAPK, and RASSF1A, by methylation-specific polymerase chain reaction, in a series of formalin-fixed paraffin-embedded tissues including normal gastric mucosa (n = 20), intestinal metaplasia (n = 14), gastric epithelial dysplasia (n = 27), and early gastric adenocarcinoma (n = 16).	Formaldehyde	180-188	RUNX family transcription factor 3	Homo sapiens	82-87
19695681-4	2009	In this study, we determined the methylation frequency of 5 genes, including p16, Runx3, MGMT, DAPK, and RASSF1A, by methylation-specific polymerase chain reaction, in a series of formalin-fixed paraffin-embedded tissues including normal gastric mucosa (n = 20), intestinal metaplasia (n = 14), gastric epithelial dysplasia (n = 27), and early gastric adenocarcinoma (n = 16).	Formaldehyde	180-188	O-6-methylguanine-DNA methyltransferase	Homo sapiens	89-93
19695681-4	2009	In this study, we determined the methylation frequency of 5 genes, including p16, Runx3, MGMT, DAPK, and RASSF1A, by methylation-specific polymerase chain reaction, in a series of formalin-fixed paraffin-embedded tissues including normal gastric mucosa (n = 20), intestinal metaplasia (n = 14), gastric epithelial dysplasia (n = 27), and early gastric adenocarcinoma (n = 16).	Formaldehyde	180-188	death associated protein kinase 1	Homo sapiens	95-99
19695681-4	2009	In this study, we determined the methylation frequency of 5 genes, including p16, Runx3, MGMT, DAPK, and RASSF1A, by methylation-specific polymerase chain reaction, in a series of formalin-fixed paraffin-embedded tissues including normal gastric mucosa (n = 20), intestinal metaplasia (n = 14), gastric epithelial dysplasia (n = 27), and early gastric adenocarcinoma (n = 16).	Formaldehyde	180-188	Ras association domain family member 1	Homo sapiens	105-112
19797612-0	2009	Sensitive detection of KRAS mutations in archived formalin-fixed paraffin-embedded tissue using mutant-enriched PCR and reverse-hybridization.	Formaldehyde	50-58	KRAS proto-oncogene, GTPase	Homo sapiens	23-27
19797612-2	2009	We report here a novel reverse-hybridization (RH) assay to screen for KRAS mutations in formalin-fixed paraffin-embedded colorectal tissue samples.	Formaldehyde	88-96	KRAS proto-oncogene, GTPase	Homo sapiens	70-74
19581629-4	2009	However, a yellow colocalization signal required aggregation/overlap of several hyaluronan/versican strands and was more pronounced after acid-ethanol-formalin fixation.	Formaldehyde	151-159	versican	Homo sapiens	91-99
19695778-5	2009	injection of dilute formalin with or without contextual conditioning exposure markedly increased the expressions of NMDA receptor subunits NR2A and NR2B but not of NR1 in the bilateral rACC.	Formaldehyde	20-28	glutamate ionotropic receptor NMDA type subunit 2A	Rattus norvegicus	139-143
19674841-9	2009	Finally, despite similar inflammatory parameters, PAR(1)-deficient mice showed a strong potentiation of inflammatory hyperalgesia induced by the intraplantar injection of either formalin or carrageenan, or in the chronic model of collagen-induced arthritis, compared to wild-type mice.	Formaldehyde	178-186	coagulation factor II (thrombin) receptor	Mus musculus	50-56
19660867-0	2009	Haeme oxygenase-1 overexpression via nAChRs and the transcription factor Nrf2 has antinociceptive effects in the formalin test.	Formaldehyde	113-121	heme oxygenase 1	Mus musculus	0-17
19660867-0	2009	Haeme oxygenase-1 overexpression via nAChRs and the transcription factor Nrf2 has antinociceptive effects in the formalin test.	Formaldehyde	113-121	nuclear factor, erythroid derived 2, like 2	Mus musculus	73-77
19660867-2	2009	Previous results from our laboratory demonstrated that HO-1 overexpression has an antinociceptive effect in the formalin test.	Formaldehyde	112-120	heme oxygenase 1	Mus musculus	55-59
19660867-4	2009	So, the aim of this study was to investigate the effect of HO-1 overexpression induced by epibatidine in nociception elicited by formalin injection in the mice hindpaw.	Formaldehyde	129-137	heme oxygenase 1	Mus musculus	59-63
19878708-0	2009	WITHDRAWN: Spinal d-amino acid oxidase contributes to the pathogenesis of hyperalgesia in the rat formalin test.	Formaldehyde	98-106	D-amino-acid oxidase	Rattus norvegicus	18-38
19746954-3	2009	The reaction between PPh(CH(2)OH)(2), iron(II) chloride, ammonium chloride, and formaldehyde under similar conditions gives cis-[FeCl(2)L(2)] (cis-2).	Formaldehyde	80-92	suppressor of cytokine signaling 2	Homo sapiens	143-148
19637342-3	2009	METHODS: Using immunohistochemical (IHC) analysis, we assessed for NPM (clone 376) expression in formalin-fixed, formic acid-decalcified bone marrow biopsy specimens.	Formaldehyde	97-105	nucleophosmin 1	Homo sapiens	67-70
19847360-0	2009	Mediating roles of the vanilloid receptor TRPV1 in activation of rat primary afferent nociceptive neurons by formaldehyde.	Formaldehyde	109-121	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	42-47
19695778-5	2009	injection of dilute formalin with or without contextual conditioning exposure markedly increased the expressions of NMDA receptor subunits NR2A and NR2B but not of NR1 in the bilateral rACC.	Formaldehyde	20-28	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	148-152
19695778-5	2009	injection of dilute formalin with or without contextual conditioning exposure markedly increased the expressions of NMDA receptor subunits NR2A and NR2B but not of NR1 in the bilateral rACC.	Formaldehyde	20-28	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	164-167
19695778-7	2009	Selectively blocking either NR2A or NR2B subunit in the rACC abolished the acquisition of F-CPA and formalin nociceptive conditioning-induced Fos expression, but it did not affect formalin acute nociceptive behaviors and non-nociceptive fear stimulus-induced CPA.	Formaldehyde	100-108	glutamate ionotropic receptor NMDA type subunit 2A	Rattus norvegicus	28-32
19695778-7	2009	Selectively blocking either NR2A or NR2B subunit in the rACC abolished the acquisition of F-CPA and formalin nociceptive conditioning-induced Fos expression, but it did not affect formalin acute nociceptive behaviors and non-nociceptive fear stimulus-induced CPA.	Formaldehyde	100-108	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	36-40
19695778-7	2009	Selectively blocking either NR2A or NR2B subunit in the rACC abolished the acquisition of F-CPA and formalin nociceptive conditioning-induced Fos expression, but it did not affect formalin acute nociceptive behaviors and non-nociceptive fear stimulus-induced CPA.	Formaldehyde	100-108	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	142-145
19650860-3	2009	Formalin-fixed, paraffin-embedded sections from endometrial cancer tissues were immunostained with the RFP antibody, and the staining intensity was evaluated.	Formaldehyde	0-8	tripartite motif containing 27	Homo sapiens	103-106
19828806-5	2009	This was associated with increased calcium influx and increased inward currents in small- and medium-sized primary sensory neurons of SNS-IKKbeta(-/-) mice during stimulation with capsaicin or Formalin, specific activators of transient receptor potentials TRPV1 and TRPA1 calcium channels, respectively.	Formaldehyde	193-201	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	256-261
19828806-5	2009	This was associated with increased calcium influx and increased inward currents in small- and medium-sized primary sensory neurons of SNS-IKKbeta(-/-) mice during stimulation with capsaicin or Formalin, specific activators of transient receptor potentials TRPV1 and TRPA1 calcium channels, respectively.	Formaldehyde	193-201	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	266-271
19801830-0	2009	Suppression of formalin-induced nociception by cilnidipine, a voltage-dependent calcium channel blocker.	Formaldehyde	15-23	calcium voltage-gated channel subunit alpha1 I	Rattus norvegicus	62-95
19449140-5	2009	Immunohistochemistry was performed on formalin-fixed sections using monoclonal antibody to IMP3.	Formaldehyde	38-46	IMP U3 small nucleolar ribonucleoprotein 3	Homo sapiens	91-95
19783717-2	2009	This study aimed to perform KRAS mutation detection on formalin-fixed paraffin-embedded (FFPE) tumour tissue by two different methods for comparison.	Formaldehyde	55-63	KRAS proto-oncogene, GTPase	Homo sapiens	28-32
19683742-4	2009	MATERIAL AND METHODS: Tissue factor expression detected by immunohistochemistry was assessed in 41 formalin fixed, paraffin embedded Wilms tumor cases treated at university hospitals.	Formaldehyde	99-107	coagulation factor III, tissue factor	Homo sapiens	22-35
19673544-0	2009	MALDI-ion mobility separation-mass spectrometry imaging of glucose-regulated protein 78 kDa (Grp78) in human formalin-fixed, paraffin-embedded pancreatic adenocarcinoma tissue sections.	Formaldehyde	109-117	heat shock protein family A (Hsp70) member 5	Homo sapiens	59-91
19673544-0	2009	MALDI-ion mobility separation-mass spectrometry imaging of glucose-regulated protein 78 kDa (Grp78) in human formalin-fixed, paraffin-embedded pancreatic adenocarcinoma tissue sections.	Formaldehyde	109-117	heat shock protein family A (Hsp70) member 5	Homo sapiens	93-98
19673544-2	2009	The use of in situ enzymatic digestion as a sample pretreatment prior to MALDI-MSI analysis has been found to be useful for retrieving protein identification directly from formalin-fixed, paraffin-embedded (ffpe) tissue sections.	Formaldehyde	172-180	RB binding protein 4, chromatin remodeling factor	Homo sapiens	79-82
19430729-3	2009	In the present study, the TIMP-1 expression was investigated immunohistochemically in 112 formalin-fixed paraffin embedded astrocytomas and related to tumour grade and overall patient survival by scoring the TIMP-1 immunoreactivity of both tumour cells and blood vessels.	Formaldehyde	90-98	TIMP metallopeptidase inhibitor 1	Homo sapiens	26-32
19617878-3	2009	KIT protein expression was evaluated by immunohistochemistry using formalin-fixed paraffin-embedded tissue.	Formaldehyde	67-75	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	0-3
19648590-3	2009	Formalin-fixed paraffin-embedded specimens were stained for VEGF-C and the correlation between the staining, its clinicopathological parameters and its prognostic power were analyzed statistically.	Formaldehyde	0-8	vascular endothelial growth factor C	Homo sapiens	60-66
19723143-4	2009	METHODS AND RESULTS: The expression of the CD133 stem cell antigen in a series of 73 patients with rectal cancer of various ypTNM stages was analysed by immunohistochemistry on formalin-fixed paraffin-embedded sections.	Formaldehyde	177-185	prominin 1	Homo sapiens	43-48
19784088-5	2009	RESULTS: The expression of GluR6 in the spinal cord of rats increased after the formalin injection.	Formaldehyde	80-88	glutamate ionotropic receptor kainate type subunit 2	Rattus norvegicus	27-32
19750576-2	2009	METHODS: Immunohistochemical methods were used to detect the expression of TS and GST-pi in surgically resected formalin-fixed, paraffin-embedded esophageal squamous cell carcinoma (ESCC) tissue sections from 102 patients (median age, 58 years) and in 28 normal esophageal mucosa (NEM) samples.	Formaldehyde	112-120	thymidylate synthetase	Homo sapiens	75-77
19576980-2	2009	MATERIALS AND METHODS: The analgesic activity of MOR(EtOH) was determined using acetic acid-induced writhing response and formalin test.	Formaldehyde	122-130	opioid receptor, mu 1	Mus musculus	49-52
19576980-5	2009	RESULTS: MOR(EtOH) (100 and 500 mg/kg) decreased the acetic acid-induced writhing responses and licking times of the second phase in the formalin test.	Formaldehyde	137-145	opioid receptor, mu 1	Mus musculus	9-12
19796081-0	2009	Oligonucleotide probe array for p53 gene alteration analysis in DNA from formalin-fixed paraffin-embedded breast cancer tissues.	Formaldehyde	73-81	tumor protein p53	Homo sapiens	32-35
19704260-0	2009	Improved diagnostic segregation of mantle cell lymphoma by determination of cyclin D1/D3 expression ratio in formalin-fixed tissue.	Formaldehyde	109-117	cyclin D1	Homo sapiens	76-85
19704260-9	2009	In conclusion, the cyclin D1/D3 expression ratio gave an improved segregation of MCLs from CLLs, FLs, MALTs, and reactive lymph nodes, as compared with determination of cyclin D1 alone in formalin-fixed, paraffin-embedded tissue.	Formaldehyde	188-196	cyclin D1	Homo sapiens	19-28
19784088-6	2009	Moreover, pre-treatment of GluR6 antisense ODNs could suppress GluR6 expression in the spinal cord of rats and decrease the scores of visceral pain at 45 min following formalin injection.	Formaldehyde	168-176	glutamate ionotropic receptor kainate type subunit 2	Rattus norvegicus	27-32
19784088-7	2009	CONCLUSION: Kainate receptor subunit GluR6 plays an important role in the visceral pain induced by injection of formalin into the wall of rectum.	Formaldehyde	112-120	glutamate ionotropic receptor kainate type subunit 2	Rattus norvegicus	37-42
19772643-7	2009	For the spatial characteristics of synaptic plasticity, BV- or formalin-induced persistent pain significantly increased the number of detectable fEPSP in both DG and CA1 area, implicating enlargement of the synaptic connection size by the injury or acute inflammation.	Formaldehyde	63-71	carbonic anhydrase 1	Rattus norvegicus	166-169
19545548-0	2009	Opposing actions of neuronal nitric oxide synthase isoforms in formalin-induced pain in mice.	Formaldehyde	63-71	nitric oxide synthase 1, neuronal	Mus musculus	20-50
19545548-3	2009	An oligodeoxynucleotide targeting four nNOS isoforms given supraspinally also reduced the formalin response of both phases.	Formaldehyde	90-98	nitric oxide synthase 1, neuronal	Mus musculus	39-43
19545548-4	2009	Supraspinal antisense mapping suggested that this effect results from the nNOS-1 splice variant, implying that nNOS-1 is important in mediating formalin pain.	Formaldehyde	144-152	nitric oxide synthase 1, neuronal	Mus musculus	74-78
19545548-4	2009	Supraspinal antisense mapping suggested that this effect results from the nNOS-1 splice variant, implying that nNOS-1 is important in mediating formalin pain.	Formaldehyde	144-152	nitric oxide synthase 1, neuronal	Mus musculus	111-115
19545548-5	2009	At the spinal level, antisense mapping suggested a role of both the nNOS-1 and the nNOS-beta variants in producing formalin pain.	Formaldehyde	115-123	nitric oxide synthase 1, neuronal	Mus musculus	68-72
19545548-5	2009	At the spinal level, antisense mapping suggested a role of both the nNOS-1 and the nNOS-beta variants in producing formalin pain.	Formaldehyde	115-123	nitric oxide synthase 1, neuronal	Mus musculus	83-87
19545548-10	2009	Local antisense mapping again showed that nNOS-1 is involved in producing phase II of the formalin response while nNOS-2 had an opposite effect similar to that seen spinally.	Formaldehyde	90-98	nitric oxide synthase 1, neuronal	Mus musculus	42-46
19545548-11	2009	Finally, downregulation of nNOS-1 by antisense prevented tolerance to morphine in both the tail-flick and the formalin test.	Formaldehyde	110-118	nitric oxide synthase 1, neuronal	Mus musculus	27-31
19521953-2	2009	In this study, we examined the expression of one such marker, the high-mobility group AT-hook 2 gene (HMGA2) mRNA, in 53 formalin-fixed, paraffin-embedded mucoepidermoid carcinomas (MEC) and four normal parotid tissues using quantitative real-time RT-PCR (qPCR).	Formaldehyde	121-129	high mobility group AT-hook 2	Homo sapiens	66-95
19521953-2	2009	In this study, we examined the expression of one such marker, the high-mobility group AT-hook 2 gene (HMGA2) mRNA, in 53 formalin-fixed, paraffin-embedded mucoepidermoid carcinomas (MEC) and four normal parotid tissues using quantitative real-time RT-PCR (qPCR).	Formaldehyde	121-129	high mobility group AT-hook 2	Homo sapiens	102-107
19551847-2	2009	The evaluation of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) expression by immunohistochemistry (IHC) is performed routinely on formalin-fixed, paraffin-embedded needle-core (NC) or excision tissue block (TB) preparations, according to the American Society of Clinical Oncology/College of American Pathologist guidelines.	Formaldehyde	189-197	erb-b2 receptor tyrosine kinase 2	Homo sapiens	116-120
19520126-0	2009	Intracerebroventricular administration of 26RFa produces an analgesic effect in the rat formalin test.	Formaldehyde	88-96	pyroglutamylated RFamide peptide	Rattus norvegicus	42-47
19520126-5	2009	Intracerebroventricular injection of 26RFa significantly decreased the number of both phase 1 and phase 2 agitation behaviors induced by paw formalin injection.	Formaldehyde	141-149	pyroglutamylated RFamide peptide	Rattus norvegicus	37-42
19460944-1	2009	Class III alcohol dehydrogenase (ADH3), also termed formaldehyde dehydrogenase or S-nitrosoglutathione reductase, plays a critical role in the enzymatic oxidation of formaldehyde and reduction of nitrosothiols that regulate bronchial tone.	Formaldehyde	52-64	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	82-112
19464247-0	2009	Pyrosequencing method to detect KRAS mutation in formalin-fixed and paraffin-embedded tumor tissues.	Formaldehyde	49-57	KRAS proto-oncogene, GTPase	Homo sapiens	32-36
19464247-2	2009	We have designed a pyrosequencing assay based on nested polymerase chain reaction (PCR) to characterize KRAS mutation status using formalin-fixed and paraffin-embedded tumor tissues.	Formaldehyde	131-139	KRAS proto-oncogene, GTPase	Homo sapiens	104-108
19464247-5	2009	Analysis of KRAS mutation using nested PCR and pyrosequencing is a simple, robust, fast, and sensitive method that can be used with formalin-fixed and paraffin-embedded tissues.	Formaldehyde	132-140	KRAS proto-oncogene, GTPase	Homo sapiens	12-16
19427893-0	2009	MKK3, an upstream activator of p38, contributes to formalin phase 2 and late allodynia in mice.	Formaldehyde	51-59	mitogen-activated protein kinase kinase 3	Mus musculus	0-4
19427893-0	2009	MKK3, an upstream activator of p38, contributes to formalin phase 2 and late allodynia in mice.	Formaldehyde	51-59	mitogen-activated protein kinase 14	Mus musculus	31-34
19427893-5	2009	The phase 2 formalin response was delayed in MKK3-/- mice, but unchanged in magnitude, while the response remained normal in MKK6-/- mice.	Formaldehyde	12-20	mitogen-activated protein kinase kinase 3	Mus musculus	45-49
19427893-6	2009	More striking, late formalin allodynia (3-18 days post-injection) was prominent in wild type and MKK6-/- mice, but was delayed for several days in MKK3-/- mice.	Formaldehyde	20-28	mitogen-activated protein kinase kinase 6	Mus musculus	97-101
19427893-7	2009	In wild type, but not MKK3-/- mice, intraplantar formalin elicited increases in ipsilateral spinal MKK3/6 phosphorylation acutely and again at 9 days postinjection.	Formaldehyde	49-57	mitogen-activated protein kinase kinase 3	Mus musculus	99-103
19427893-8	2009	Phosphorylation of MKK3/6 correlated with phase 2 formalin behavior.	Formaldehyde	50-58	mitogen-activated protein kinase kinase 3	Mus musculus	19-23
19389046-4	2009	The effects of isoflurane and nicotine on paw licking times and formalin-induced c-fos expression in the spinal cord dorsal horn were examined.	Formaldehyde	64-72	FBJ osteosarcoma oncogene	Mus musculus	81-86
19389046-5	2009	Our correlative studies have shown that isoflurane can decrease the paw licking times and simultaneously suppress c-fos expression after injection of formalin in the mice.	Formaldehyde	150-158	FBJ osteosarcoma oncogene	Mus musculus	114-119
19473342-0	2009	Formalin-induced increase in P2X(3) receptor expression in dorsal root ganglia: implications for nociception.	Formaldehyde	0-8	purinergic receptor P2X 3	Rattus norvegicus	29-35
19473342-3	2009	The effect of formalin on the expression of P2X(3) receptors in dorsal root ganglia (DRG) was characterized using molecular and immunological approaches and the patch-clamp technique.	Formaldehyde	14-22	purinergic receptor P2X 3	Rattus norvegicus	44-50
19473342-10	2009	Expression of the P2X(3) transcript in the DRG was unchanged 30 min and 1 h after formalin injection, but increased after 12 h. There was no distinct change in P2X(3) immunostaining of the spinal cord lamina at 30 min or 1 h after injection, but after 24 h P2X(3) labelling increased.	Formaldehyde	82-90	purinergic receptor P2X 3	Rattus norvegicus	18-24
19473342-14	2009	These data suggest that formalin injection leads to early upregulation of P2X(3) expression in the spinal cord and DRG and that this may be one of the mechanisms giving rise to nociception.	Formaldehyde	24-32	purinergic receptor P2X 3	Rattus norvegicus	74-80
21155253-8	2009	The number and staining degree of NADPH-d positive neurons in formalin group significantly increased at 12 h after the formalin injection in CA1, CA2-3 and DG of hippocampus compared with control group as well as NO content, however, the number and staining degree of NADPH-d positive neurons in formalin + MK-801 group significantly decreased in contrast to those of formalin 12 h group as well as the NO content (P &lt; 0.01).	Formaldehyde	62-70	carbonic anhydrase 1	Rattus norvegicus	141-144
18938093-3	2009	None of the knockouts was uniformly protected from all of these pain stimuli but COX-1 and EP4 receptor knockouts presented with reduced heat pain and EP3 receptor and COX-2 knockout mice had reduced licking responses in the 2nd phase of the formalin assay.	Formaldehyde	242-250	cytochrome c oxidase II, mitochondrial	Mus musculus	168-173
18938093-6	2009	Deficiency of either EP2 or DP1 was associated with increased formalin-evoked flinching responses and c-Fos IR in dorsal horn neurons suggesting facilitated spinal cord pain reflex circuity.	Formaldehyde	62-70	prostaglandin E receptor 2 (subtype EP2)	Mus musculus	21-24
18938093-6	2009	Deficiency of either EP2 or DP1 was associated with increased formalin-evoked flinching responses and c-Fos IR in dorsal horn neurons suggesting facilitated spinal cord pain reflex circuity.	Formaldehyde	62-70	transcription factor Dp 1	Mus musculus	28-31
19464798-0	2009	The beta3 subunit of the Na+,K+-ATPase mediates variable nociceptive sensitivity in the formalin test.	Formaldehyde	88-96	calcium channel, voltage-dependent, beta 3 subunit	Mus musculus	4-9
19464798-2	2009	Computational genetic mapping and quantitative trait locus analysis suggested that variation within the gene coding for the beta3 subunit of the Na+,K+-ATPase pump (Atp1b3) contributes to inter-strain differences in the early phase formalin pain behavior.	Formaldehyde	232-240	calcium channel, voltage-dependent, beta 3 subunit	Mus musculus	124-129
19464798-2	2009	Computational genetic mapping and quantitative trait locus analysis suggested that variation within the gene coding for the beta3 subunit of the Na+,K+-ATPase pump (Atp1b3) contributes to inter-strain differences in the early phase formalin pain behavior.	Formaldehyde	232-240	ATPase, Na+/K+ transporting, beta 3 polypeptide	Mus musculus	165-171
19488035-7	2009	We found that anti-CD44v6 and CD24 antibodies that were directly conjugated to quantum dots retained their ability to recognize antigen in formalin-fixed, paraffin-embedded tissue sections.	Formaldehyde	139-147	CD24 molecule	Homo sapiens	30-34
21155253-8	2009	The number and staining degree of NADPH-d positive neurons in formalin group significantly increased at 12 h after the formalin injection in CA1, CA2-3 and DG of hippocampus compared with control group as well as NO content, however, the number and staining degree of NADPH-d positive neurons in formalin + MK-801 group significantly decreased in contrast to those of formalin 12 h group as well as the NO content (P &lt; 0.01).	Formaldehyde	62-70	carbonic anhydrase 2	Rattus norvegicus	146-151
21155253-8	2009	The number and staining degree of NADPH-d positive neurons in formalin group significantly increased at 12 h after the formalin injection in CA1, CA2-3 and DG of hippocampus compared with control group as well as NO content, however, the number and staining degree of NADPH-d positive neurons in formalin + MK-801 group significantly decreased in contrast to those of formalin 12 h group as well as the NO content (P &lt; 0.01).	Formaldehyde	119-127	carbonic anhydrase 1	Rattus norvegicus	141-144
21155253-8	2009	The number and staining degree of NADPH-d positive neurons in formalin group significantly increased at 12 h after the formalin injection in CA1, CA2-3 and DG of hippocampus compared with control group as well as NO content, however, the number and staining degree of NADPH-d positive neurons in formalin + MK-801 group significantly decreased in contrast to those of formalin 12 h group as well as the NO content (P &lt; 0.01).	Formaldehyde	119-127	carbonic anhydrase 2	Rattus norvegicus	146-151
21155253-8	2009	The number and staining degree of NADPH-d positive neurons in formalin group significantly increased at 12 h after the formalin injection in CA1, CA2-3 and DG of hippocampus compared with control group as well as NO content, however, the number and staining degree of NADPH-d positive neurons in formalin + MK-801 group significantly decreased in contrast to those of formalin 12 h group as well as the NO content (P &lt; 0.01).	Formaldehyde	119-127	carbonic anhydrase 1	Rattus norvegicus	141-144
21155253-8	2009	The number and staining degree of NADPH-d positive neurons in formalin group significantly increased at 12 h after the formalin injection in CA1, CA2-3 and DG of hippocampus compared with control group as well as NO content, however, the number and staining degree of NADPH-d positive neurons in formalin + MK-801 group significantly decreased in contrast to those of formalin 12 h group as well as the NO content (P &lt; 0.01).	Formaldehyde	119-127	carbonic anhydrase 2	Rattus norvegicus	146-151
21155253-8	2009	The number and staining degree of NADPH-d positive neurons in formalin group significantly increased at 12 h after the formalin injection in CA1, CA2-3 and DG of hippocampus compared with control group as well as NO content, however, the number and staining degree of NADPH-d positive neurons in formalin + MK-801 group significantly decreased in contrast to those of formalin 12 h group as well as the NO content (P &lt; 0.01).	Formaldehyde	119-127	carbonic anhydrase 1	Rattus norvegicus	141-144
21155253-8	2009	The number and staining degree of NADPH-d positive neurons in formalin group significantly increased at 12 h after the formalin injection in CA1, CA2-3 and DG of hippocampus compared with control group as well as NO content, however, the number and staining degree of NADPH-d positive neurons in formalin + MK-801 group significantly decreased in contrast to those of formalin 12 h group as well as the NO content (P &lt; 0.01).	Formaldehyde	119-127	carbonic anhydrase 2	Rattus norvegicus	146-151
19363440-2	2009	We evaluated the utility of a monoclonal antibody directed against microtubule associated protein-2 (MAP-2), a marker of neuronal differentiation, to detect ganglion cells in formalin-fixed, paraffin-embedded tissue sections.	Formaldehyde	175-183	microtubule associated protein 2	Homo sapiens	67-99
19635143-4	2009	METHODS: MGB-2 expression was evaluated by quantitative real time-PCR in fresh-frozen tissue biopsies and was validated by immunohistochemistry in matched formalin fixed-paraffin embedded tissue samples derived from a total of 106 EOC patients and 27 controls.	Formaldehyde	155-163	secretoglobin family 2A member 1	Homo sapiens	9-14
19580660-6	2009	RESULTS: We first demonstrated that spinally administered NT and NT69L agonists, which bind to both NTS1 and NTS2 receptors, significantly reduced pain-evoked responses during the inflammatory phase of the formalin test.	Formaldehyde	206-214	neurotensin	Homo sapiens	58-60
19580660-6	2009	RESULTS: We first demonstrated that spinally administered NT and NT69L agonists, which bind to both NTS1 and NTS2 receptors, significantly reduced pain-evoked responses during the inflammatory phase of the formalin test.	Formaldehyde	206-214	neurotensin	Homo sapiens	100-104
19580660-8	2009	With resolution at the single-cell level, we also found that activation of spinal NTS2 receptors reduced formalin-induced c-fos expression in dorsal horn neurons.	Formaldehyde	105-113	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	122-127
19363440-2	2009	We evaluated the utility of a monoclonal antibody directed against microtubule associated protein-2 (MAP-2), a marker of neuronal differentiation, to detect ganglion cells in formalin-fixed, paraffin-embedded tissue sections.	Formaldehyde	175-183	microtubule associated protein 2	Homo sapiens	101-106
19894558-2	2009	METHOD: Two-step immunohistochemical staining was applied to detect the expression of E-cadherin and P(120ctn) in formalin fixation and paraffin-embedded specimens from 56 cases with nasopharyngeal carcinoma and 15 cases with normal nasopharyngeal epithelia.	Formaldehyde	114-122	cadherin 1	Homo sapiens	86-96
19656999-2	2009	MATERIALS AND METHODS: The O(6)-methylguanine-DNA methyltransferase (MGMT) status was evaluated by methylation-specific PCR (MSP), immunohistochemistry and Western blotting analysis in formalin-fixed paraffin-embedded surgical samples.	Formaldehyde	185-193	O-6-methylguanine-DNA methyltransferase	Homo sapiens	27-67
19656999-2	2009	MATERIALS AND METHODS: The O(6)-methylguanine-DNA methyltransferase (MGMT) status was evaluated by methylation-specific PCR (MSP), immunohistochemistry and Western blotting analysis in formalin-fixed paraffin-embedded surgical samples.	Formaldehyde	185-193	O-6-methylguanine-DNA methyltransferase	Homo sapiens	69-73
19374895-3	2009	The prognostic significance of RASSF1A methylation was validated in 93 formalin fixed paraffin-embedded (FFPE) tissues obtained from patients with operable breast cancer.	Formaldehyde	71-79	Ras association domain family member 1	Homo sapiens	31-38
18996001-8	2009	The effects of formaldehyde inhalation on the distribution of occludin, E-cadherin, and gamma-catenin were assessed by immunohistochemistry.	Formaldehyde	15-27	occludin	Rattus norvegicus	62-70
18996001-8	2009	The effects of formaldehyde inhalation on the distribution of occludin, E-cadherin, and gamma-catenin were assessed by immunohistochemistry.	Formaldehyde	15-27	cadherin 1	Rattus norvegicus	72-82
19317849-3	2009	We analysed EGFR expression using immunohistochemistry on formalin-fixed, paraffin embedded surgical specimens of all patients.	Formaldehyde	58-66	epidermal growth factor receptor	Homo sapiens	12-16
19345285-4	2009	METHODS: A monoclonal antibody specific for an eosinophil secondary granule protein (eosinophil peroxidase [EPX]) was developed and shown to specifically identify intact eosinophils and detect eosinophil degranulation in formalin-fixed specimens.	Formaldehyde	221-229	eosinophil peroxidase	Homo sapiens	85-106
19345285-4	2009	METHODS: A monoclonal antibody specific for an eosinophil secondary granule protein (eosinophil peroxidase [EPX]) was developed and shown to specifically identify intact eosinophils and detect eosinophil degranulation in formalin-fixed specimens.	Formaldehyde	221-229	eosinophil peroxidase	Homo sapiens	108-111
18801682-9	2009	Following formalin injection, ASIC1(-/-) and ASIC2(-/-), but not ASIC3(-/-) or TRPV1(-/-), mice showed enhanced pain behaviour, predominantly in the second phase of the test.	Formaldehyde	10-18	acid-sensing (proton-gated) ion channel 1	Mus musculus	30-35
18801682-9	2009	Following formalin injection, ASIC1(-/-) and ASIC2(-/-), but not ASIC3(-/-) or TRPV1(-/-), mice showed enhanced pain behaviour, predominantly in the second phase of the test.	Formaldehyde	10-18	acid-sensing (proton-gated) ion channel 2	Mus musculus	45-50
19894558-2	2009	METHOD: Two-step immunohistochemical staining was applied to detect the expression of E-cadherin and P(120ctn) in formalin fixation and paraffin-embedded specimens from 56 cases with nasopharyngeal carcinoma and 15 cases with normal nasopharyngeal epithelia.	Formaldehyde	114-122	catenin delta 1	Homo sapiens	101-109
19494791-3	2009	NQO1 protein levels were immunohistochemically determined in formalin-fixed paraffin-embedded tissues.	Formaldehyde	61-69	NAD(P)H quinone dehydrogenase 1	Homo sapiens	0-4
19568416-10	2009	We further performed a large cohort study (n = 113) to examine the LMO2 messenger RNA levels in formalin-fixed paraffin-embedded samples and found similar results.	Formaldehyde	96-104	LIM domain only 2	Homo sapiens	67-71
19138726-0	2009	Neuropeptide Y receptor-expressing dorsal horn neurons: role in nocifensive reflex responses to heat and formalin.	Formaldehyde	105-113	neuropeptide Y	Mus musculus	0-14
19604345-3	2009	The aim of this study was to analyze the expression of NOD1 and NOD2 proteins in healthy mouse and dog eyes using immunohistochemistry on formalin-fixed, paraffin-embedded globes.	Formaldehyde	138-146	nucleotide-binding oligomerization domain containing 1	Mus musculus	55-59
19604345-3	2009	The aim of this study was to analyze the expression of NOD1 and NOD2 proteins in healthy mouse and dog eyes using immunohistochemistry on formalin-fixed, paraffin-embedded globes.	Formaldehyde	138-146	nucleotide-binding oligomerization domain containing 2	Mus musculus	64-68
19306859-8	2009	Applying immunohistochemistry, we further validated alpha1-AT immunoreactivity in 51 formalin-fixed paraffin-embedded sections of breast tumors.	Formaldehyde	85-93	serpin family A member 1	Homo sapiens	52-61
19429157-0	2009	Down-regulation of K+ -Cl- co-transporter 2 in mouse medullary dorsal horn contributes to the formalin-induced inflammatory orofacial pain.	Formaldehyde	94-102	solute carrier family 12, member 5	Mus musculus	19-43
19429157-3	2009	In this study, we investigated the behavioral changes and the accompanying change in the expressions of KCC2 and NKCC1 mRNAs in mouse medullary dorsal horn (MDH) after subcutaneous injection of formalin into the left vibrissa pad.	Formaldehyde	194-202	solute carrier family 12, member 5	Mus musculus	104-108
19429157-3	2009	In this study, we investigated the behavioral changes and the accompanying change in the expressions of KCC2 and NKCC1 mRNAs in mouse medullary dorsal horn (MDH) after subcutaneous injection of formalin into the left vibrissa pad.	Formaldehyde	194-202	solute carrier family 12, member 2	Mus musculus	113-118
19429157-6	2009	Real-time reverse transcriptase-polymerase chain reaction (RT-PCR) results indicated that, compared to the saline control or the contralateral side, the ipsilateral mRNA level of KCC2 but not NKCC1, was significantly reduced in formalin-injected mice during phase 1 observation, followed by gradual recovery.	Formaldehyde	228-236	solute carrier family 12, member 5	Mus musculus	179-183
19429157-7	2009	Intracisternal injection of KCC2 ASO into naive mice led to behavioral hypersensitivity similar to the hyperalgesia observed in formalin experiments.	Formaldehyde	128-136	solute carrier family 12, member 5	Mus musculus	28-32
19552806-11	2009	CONCLUSION: We have generated a novel, highly-specific monoclonal antibody that detects RAI3 in formaldehyde-fixed paraffin-embedded tissue.	Formaldehyde	96-108	G protein-coupled receptor class C group 5 member A	Homo sapiens	88-92
19138726-8	2009	NPY-sap also reduced formalin-induced nocifensive behaviors during both interphase and phase II.	Formaldehyde	21-29	neuropeptide Y	Mus musculus	0-3
19376128-4	2009	With this view, we have systematically analyzed here the role of Mdm30p in regulation of transcriptional initiation, elongation, mRNA processing, and export in Saccharomyces cerevisiae, using a formaldehyde-based in vivo cross-linking and chromatin immunoprecipitation assay in conjunction with RT-PCR and fluorescence in situ hybridization.	Formaldehyde	194-206	SCF ubiquitin ligase complex subunit MDM30	Saccharomyces cerevisiae S288C	65-71
19430293-1	2009	The aim of the study was to screen formalin-fixed, paraffin-embedded tissues of polycythemia vera patients for the presence of JAK2(V617F) and JAK2 exon 12 mutations.	Formaldehyde	35-43	Janus kinase 2	Homo sapiens	127-131
19500426-4	2009	We investigated this by inhibiting the activity of mTOR with rapamycin at the spinal level, of rats that were subjected to the formalin test, using both behavioural and electrophysiological techniques.	Formaldehyde	127-135	mechanistic target of rapamycin kinase	Rattus norvegicus	51-55
19184326-8	2009	The activity of class III alcohol dehydrogenase was measured by the photometric method with formaldehyde and class IV with m-nitrobenzaldehyde as a substrate.	Formaldehyde	92-104	aldo-keto reductase family 1 member A1	Homo sapiens	26-47
19430293-1	2009	The aim of the study was to screen formalin-fixed, paraffin-embedded tissues of polycythemia vera patients for the presence of JAK2(V617F) and JAK2 exon 12 mutations.	Formaldehyde	35-43	Janus kinase 2	Homo sapiens	143-147
19462165-6	2009	A considerable numbers of c-Fos-immunoreactive (IR) cells were induced in the caudal and inter-medio-lateral center of superficial layers of the Vc (VcI/II; mean +/- SEM/section = 225.8 +/- 12.9) and magnocellular zone of the Vc (VcIII/IV; 67.1 +/- 4.7) 2 h after formalin injection into the lip.	Formaldehyde	264-272	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	26-31
19462165-7	2009	Much smaller numbers of c-Fos-IR cells were induced in the rostral and dorso-medial one-fourth of the VcI/II (72.6 +/- 3.7) and VcIII/IV (55.6 +/- 6.6) after formalin injection into the tongue.	Formaldehyde	158-166	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	24-29
19462165-8	2009	Following preadministration with systemic bicuculline or morphine, the formalin-induced c-Fos-IR cells were decreased more in the VcI/II when formalin was injected into the lip (VcI/II, 102.4 +/- 8.0; VcIII/IV, 32.8 +/- 1.4) than into the tongue (VcI/II, 49.5 +/- 8.1; VcIII/IV, 31.7 +/- 5.3).	Formaldehyde	71-79	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	88-93
19462165-8	2009	Following preadministration with systemic bicuculline or morphine, the formalin-induced c-Fos-IR cells were decreased more in the VcI/II when formalin was injected into the lip (VcI/II, 102.4 +/- 8.0; VcIII/IV, 32.8 +/- 1.4) than into the tongue (VcI/II, 49.5 +/- 8.1; VcIII/IV, 31.7 +/- 5.3).	Formaldehyde	142-150	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	88-93
18939936-2	2009	SPI biofilms were prepared from SPI chemically treated with formaldehyde at various concentrations (0%, 1%, 2%, and 3%) as cross-linking agents.	Formaldehyde	60-72	chromogranin A	Homo sapiens	0-3
18939936-7	2009	The resulting SPI biofilms without formaldehyde swell significantly, which leads to their physical instability.	Formaldehyde	35-47	chromogranin A	Homo sapiens	14-17
18939936-10	2009	SPI biofilms with 2% and 3% formaldehyde were highly stable and easier to manipulate than those with 0% and 1% formaldehyde.	Formaldehyde	28-40	chromogranin A	Homo sapiens	0-3
18939936-10	2009	SPI biofilms with 2% and 3% formaldehyde were highly stable and easier to manipulate than those with 0% and 1% formaldehyde.	Formaldehyde	111-123	chromogranin A	Homo sapiens	0-3
19077907-7	2009	A national study of 109 participating clinical laboratories demonstrated a good correlation between a laboratory"s ability to properly stain formalin-fixed peptide controls to their ability in properly staining a 3+ HER-2 formalin-fixed tissue section mounted on the same slide (r=0.87).	Formaldehyde	222-230	erb-b2 receptor tyrosine kinase 2	Homo sapiens	216-221
19590775-1	2009	The first step of the base-promoted decomposition of N-chloro,N-methylethanolamine in aqueous solution (CH3N(Cl)CH2CH2OH + HO- --&gt; imine + Cl- + H2O (+ CH2O) --&gt; amine + aldehyde) is investigated at the MP2/6-31++G(d,p) computing level.	Formaldehyde	115-119	tryptase pseudogene 1	Homo sapiens	209-212
19429351-8	2009	Pretreatment with bicuculline, a GABA(A) antagonist, reduced the antinociceptive effects of ARE on the formalin- or NMDA-induced behaviors.	Formaldehyde	103-111	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	33-40
19575985-3	2009	The expression of hypoxia inducible factor 1 alpha (HIF-1alpha) was examined by immunohistochemical staining in 42 cases of formalin-fixed paraffin-embed squamous cell carcinoma.	Formaldehyde	124-132	hypoxia inducible factor 1 subunit alpha	Homo sapiens	18-50
19157508-2	2009	The expression of epithelial cell adhesion molecule and E-cadherin was examined immunohistochemically on a tissue microarray of formalin-fixed paraffin-embedded tissue specimens from 72 consecutive patients.	Formaldehyde	128-136	epithelial cell adhesion molecule	Homo sapiens	18-51
19509563-4	2009	miR-29b expression was analyzed using quantitative stem-loop reverse transcriptase polymerase chain reaction on a set of 50 formalin-fixed, paraffin-embedded ovarian serous carcinoma samples.	Formaldehyde	124-132	microRNA 29b-1	Homo sapiens	0-7
19428770-2	2009	This study assesses the participation of ET(A) and ET(B) receptors on the nociceptive behavior and hyperalgesia to chemical (formalin), mechanical and thermal stimuli evoked by endothelin-1 injected into the rat hind-paw.	Formaldehyde	125-133	endothelin receptor type B	Rattus norvegicus	51-56
19428770-2	2009	This study assesses the participation of ET(A) and ET(B) receptors on the nociceptive behavior and hyperalgesia to chemical (formalin), mechanical and thermal stimuli evoked by endothelin-1 injected into the rat hind-paw.	Formaldehyde	125-133	endothelin 1	Rattus norvegicus	177-189
19366608-9	2009	Using formaldehyde cross-linking we demonstrate that MTERF2 is present in nucleoids, and therefore must be located in close proximity to mtDNA.	Formaldehyde	6-18	mitochondrial transcription termination factor 2	Homo sapiens	53-59
18656400-9	2009	These drugs inhibited c-fos expression in the superficial layer of the spinal dorsal horn of segments L4-5 at 2h after formalin injection.	Formaldehyde	119-127	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	22-27
19372290-7	2009	A non-significant increase in ALS mortality was found among individuals who reported exposure to formaldehyde (RR 1.34; 95% CI 0.93 to 1.92).	Formaldehyde	97-109	superoxide dismutase 1	Homo sapiens	30-33
19372290-10	2009	In contrast, evidence was found, suggesting an increased risk of ALS with formaldehyde exposure.	Formaldehyde	74-86	superoxide dismutase 1	Homo sapiens	65-68
19575985-3	2009	The expression of hypoxia inducible factor 1 alpha (HIF-1alpha) was examined by immunohistochemical staining in 42 cases of formalin-fixed paraffin-embed squamous cell carcinoma.	Formaldehyde	124-132	hypoxia inducible factor 1 subunit alpha	Homo sapiens	52-62
21189548-6	2009	RESULTS: Compared with control group, the apoptotic ratio of hippocampal neurons was significantly increased in rats with inflammatory pain, and formalin inflammatory pain induced upregulation of p53 protein expression in all hippocampal subregions.	Formaldehyde	145-153	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	196-199
21189548-7	2009	Both the apoptotic ratio and the p53 protein expression peaked on the third day after the formalin injection.	Formaldehyde	90-98	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	33-36
21189552-0	2009	[Activation of periphery group III metabotropic glutamate receptors inhibits formalin-induced activation of spinal p38-MAPK in rats].	Formaldehyde	77-85	mitogen activated protein kinase 14	Rattus norvegicus	115-118
21189556-0	2009	[The effect of formalin-induced pain on CCK in rat spinal cord neurons].	Formaldehyde	15-23	cholecystokinin	Rattus norvegicus	40-43
19231081-4	2009	Using a new behavioral model of DNIC, in which facial grooming produced by formalin injection into the vibrissa pad is inhibited by a conditioning noxious stimulation, formalin injection into the hindpaw, we show that blockade of NK1 receptors in the lumbar spinal cord - by intrathecal administration of the NK1 receptor antagonist, RP67580 - largely attenuates DNIC-induced facial analgesia.	Formaldehyde	75-83	tachykinin receptor 1	Rattus norvegicus	230-242
21189556-2	2009	This study explores the modulatory effect of CCK on pain formalin-induced.	Formaldehyde	57-65	cholecystokinin	Rattus norvegicus	45-48
21189556-3	2009	METHODS: The effect of formalin-induced pain on CCK immunoreactivity in rat sensory neurons was observed through immunohistochemistry technique.	Formaldehyde	23-31	cholecystokinin	Rattus norvegicus	48-51
21189556-4	2009	RESULTS: After 1 h of subcutaneous injection of formalin in one paw of rats, the number of positive neurons of CCK immunoreactivity in spinal cord neurons was obviously increased and greater than that of non-injection side (P &lt;0.01).	Formaldehyde	48-56	cholecystokinin	Rattus norvegicus	111-114
21189556-6	2009	After 3 h of subcutaneous injection of formalin in one paw of rats, the semi-quantitative optical density average values of CCK immunoreactivity neurons were 0.366 +/- 0.009 and 0.303 +/- 0.005 in injection side and noninjection side respectively, the difference was significant (P &lt; 0.01).	Formaldehyde	39-47	cholecystokinin	Rattus norvegicus	124-127
21189556-7	2009	CONCLUSION: Formalin-induced pain can significantly change semi-quantitative optical density average value of CCK immunoractivity in spinal cord neurons, this indicates CCK participates in modulation of pain.	Formaldehyde	12-20	cholecystokinin	Rattus norvegicus	110-113
21189556-7	2009	CONCLUSION: Formalin-induced pain can significantly change semi-quantitative optical density average value of CCK immunoractivity in spinal cord neurons, this indicates CCK participates in modulation of pain.	Formaldehyde	12-20	cholecystokinin	Rattus norvegicus	169-172
19383149-9	2009	CONCLUSION: Our data show that acute pharmacological blockade of TRPA1 at the cutaneous receptive field inhibits formalin-evoked activation and markedly reduces mechanically-evoked action potential firing in C fibers.	Formaldehyde	113-121	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	65-70
19358724-4	2009	METHODS: The presence of KRAS mutations in codon 12 and 13 was analyzed in frozen and formalin-fixed paraffin-embedded (FFPE) tissue with a low density biochip platform.	Formaldehyde	86-94	KRAS proto-oncogene, GTPase	Homo sapiens	25-29
18567517-4	2009	Endomorphin-2 vector injection also reduced spontaneous pain-related behaviors in the delayed phase of the formalin test and in both CFA and formalin models suppressed spinal c-fos expression.	Formaldehyde	141-149	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	175-180
19852088-3	2009	A DNA repair protein in Escherichia coli, AlkB, corrects some of the unwanted methylations of DNA bases by a unique oxidative demethylation in which the methyl carbon is liberated as formaldehyde.	Formaldehyde	183-195	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	42-46
19256510-1	2009	Weak interactions of monosubstituted formaldehydes and thioformaldehydes with nitrosyl hydride were investigated by using ab initio MO calculations at the MP2/aug-cc-pVTZ level.	Formaldehyde	37-50	tryptase pseudogene 1	Homo sapiens	155-158
19185544-0	2009	siRNA-mediated knockdown of the NR1 subunit gene of the NMDA receptor attenuates formalin-induced pain behaviors in adult rats.	Formaldehyde	81-89	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	32-35
19185544-6	2009	Vector 6 also prevented the increase in phosphorylated NR1 levels seen in the ipsilateral SCDH of control rats 45 minutes after formalin.	Formaldehyde	128-136	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	55-58
19185544-7	2009	These results indicate that vector-derived siRNAs can effectively produce spatial knockdown of NR1 gene expression, and this knockdown selectively attenuates in vivo NMDA receptor-mediated formalin behaviors and NR1 phosphorylation in the rat.	Formaldehyde	189-197	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	95-98
19231081-4	2009	Using a new behavioral model of DNIC, in which facial grooming produced by formalin injection into the vibrissa pad is inhibited by a conditioning noxious stimulation, formalin injection into the hindpaw, we show that blockade of NK1 receptors in the lumbar spinal cord - by intrathecal administration of the NK1 receptor antagonist, RP67580 - largely attenuates DNIC-induced facial analgesia.	Formaldehyde	168-176	tachykinin receptor 1	Rattus norvegicus	230-242
20076883-2	2009	METHODS: The immunohistochemical expression of Her-2/Neu was studied in 37 formalin-fixed paraffin-embedded tissue sections.	Formaldehyde	75-83	erb-b2 receptor tyrosine kinase 2	Homo sapiens	47-56
19370270-0	2009	Formaldehyde cross-linking of proteins to osteoclast differentiation factor promoter for the identification of biofunctional proteins.	Formaldehyde	0-12	TNF superfamily member 11	Homo sapiens	42-75
19034430-5	2009	The same sediment samples were also probed for genes coding for methanol dehydrogenase (MDH) (catalyzing the oxidation of methanol to formaldehyde) to assess specifically changes in methylotrophic bacterial populations in the site.	Formaldehyde	134-146	malate dehydrogenase 2	Homo sapiens	64-86
19368817-1	2009	In the present study, the activation of extracellular signal-regulated kinase (ERK) in the locus coeruleus (LC) following injection of formalin or complete Freund"s adjuvant (CFA) into the rat hindpaw was examined in order to clarify the mechanisms underlying the dynamic changes in the descending pain modulatory system after acute noxious stimulation or chronic inflammation.	Formaldehyde	135-143	Eph receptor B1	Rattus norvegicus	40-77
19368817-1	2009	In the present study, the activation of extracellular signal-regulated kinase (ERK) in the locus coeruleus (LC) following injection of formalin or complete Freund"s adjuvant (CFA) into the rat hindpaw was examined in order to clarify the mechanisms underlying the dynamic changes in the descending pain modulatory system after acute noxious stimulation or chronic inflammation.	Formaldehyde	135-143	Eph receptor B1	Rattus norvegicus	79-82
19368817-3	2009	Formalin-, CFA- and saline-injections induced an increase in p-ERK-IR in the LC.	Formaldehyde	0-8	Eph receptor B1	Rattus norvegicus	63-66
19368817-4	2009	The number of p-ERK-IR neurons in the LC in the formalin group was significantly higher than those in all other groups from 5 min to 1 h after the injection (p&lt;0.05).	Formaldehyde	48-56	Eph receptor B1	Rattus norvegicus	16-19
19368817-6	2009	At 5 min after formalin injection, almost all p-ERK-IR neurons in the LC were tyrosine hydroxylase (TH) -positive.	Formaldehyde	15-23	Eph receptor B1	Rattus norvegicus	48-51
19368817-7	2009	These findings suggest that activation of ERK in the LC is induced by acute noxious stimulation, such as formalin injection, but not by CFA-induced chronic inflammation.	Formaldehyde	105-113	Eph receptor B1	Rattus norvegicus	42-45
19038239-2	2009	Mammalian alcohol dehydrogenase 3 (ADH3) represents the key enzyme in the formaldehyde detoxification pathway by oxidation of S-hydroxymethylglutathione [HMGSH; the glutathione (GSH) adduct of formaldehyde].	Formaldehyde	74-86	alcohol dehydrogenase 1C (class I), gamma polypeptide	Homo sapiens	10-33
19038239-2	2009	Mammalian alcohol dehydrogenase 3 (ADH3) represents the key enzyme in the formaldehyde detoxification pathway by oxidation of S-hydroxymethylglutathione [HMGSH; the glutathione (GSH) adduct of formaldehyde].	Formaldehyde	74-86	alcohol dehydrogenase 1C (class I), gamma polypeptide	Homo sapiens	35-39
19038239-2	2009	Mammalian alcohol dehydrogenase 3 (ADH3) represents the key enzyme in the formaldehyde detoxification pathway by oxidation of S-hydroxymethylglutathione [HMGSH; the glutathione (GSH) adduct of formaldehyde].	Formaldehyde	193-205	alcohol dehydrogenase 1C (class I), gamma polypeptide	Homo sapiens	10-33
19038239-2	2009	Mammalian alcohol dehydrogenase 3 (ADH3) represents the key enzyme in the formaldehyde detoxification pathway by oxidation of S-hydroxymethylglutathione [HMGSH; the glutathione (GSH) adduct of formaldehyde].	Formaldehyde	193-205	alcohol dehydrogenase 1C (class I), gamma polypeptide	Homo sapiens	35-39
19038239-12	2009	These findings provided evidence for formaldehyde-induced, ADH3-mediated GSNO depletion with potential direct implications for asthma.	Formaldehyde	37-49	alcohol dehydrogenase 1C (class I), gamma polypeptide	Homo sapiens	59-63
19279268-4	2009	Intraplantar formalin injection produced a transient ERK activation in laminae V-VI and a persistent ERK activation in laminae II-III of the rostral ACC (rACC) bilaterally.	Formaldehyde	13-21	Eph receptor B1	Rattus norvegicus	53-56
19279268-4	2009	Intraplantar formalin injection produced a transient ERK activation in laminae V-VI and a persistent ERK activation in laminae II-III of the rostral ACC (rACC) bilaterally.	Formaldehyde	13-21	Eph receptor B1	Rattus norvegicus	101-104
19279268-5	2009	Using formalin-induced conditioned place avoidance (F-CPA) in rats, which is believed to reflect the pain-related negative emotion, we found that blockade of ERK activation in the rACC with MEK inhibitors prevented the induction of F-CPA.	Formaldehyde	6-14	Eph receptor B1	Rattus norvegicus	158-161
19279268-9	2009	Downstream, phosphorylation of cAMP response element binding protein (CREB) was induced in the rACC by formalin injection and by NMDA, AC and PKA activators in brain slices, which was suppressed by MEK inhibitors.	Formaldehyde	103-111	cAMP responsive element binding protein 1	Rattus norvegicus	31-68
19279268-9	2009	Downstream, phosphorylation of cAMP response element binding protein (CREB) was induced in the rACC by formalin injection and by NMDA, AC and PKA activators in brain slices, which was suppressed by MEK inhibitors.	Formaldehyde	103-111	cAMP responsive element binding protein 1	Rattus norvegicus	70-74
19034430-5	2009	The same sediment samples were also probed for genes coding for methanol dehydrogenase (MDH) (catalyzing the oxidation of methanol to formaldehyde) to assess specifically changes in methylotrophic bacterial populations in the site.	Formaldehyde	134-146	malate dehydrogenase 2	Homo sapiens	88-91
19214113-0	2009	A novel proximity assay for the detection of proteins and protein complexes: quantitation of HER1 and HER2 total protein expression and homodimerization in formalin-fixed, paraffin-embedded cell lines and breast cancer tissue.	Formaldehyde	156-164	erb-b2 receptor tyrosine kinase 2	Homo sapiens	102-106
19054153-3	2009	METHODS: Immunohistochemistry for mutL homolog 1 (MLH1), mutS homolog 2 (MSH2), mutS homolog 6 (MSH6) and post-meiotic segregation increased 2 (PMS2) was carried out on formalin-fixed and paraffin-embedded sections of tumor and background liver.	Formaldehyde	169-177	mutS homolog 6	Homo sapiens	96-100
19052772-0	2009	Vinculin and cellular retinol-binding protein-1 are markers for quiescent and activated hepatic stellate cells in formalin-fixed paraffin embedded human liver.	Formaldehyde	114-122	vinculin	Homo sapiens	0-8
19129543-4	2009	Here, we monitored the chromatin structure at FOXA1 binding sites on a chromosome-wide scale using formaldehyde assisted isolation of regulatory elements (FAIRE).	Formaldehyde	99-111	forkhead box A1	Homo sapiens	46-51
19318328-6	2009	In addition, formalin provided superior morphology and better reactivity with claudin-4 and -7 immunohistochemistry.	Formaldehyde	13-21	claudin 4	Homo sapiens	78-87
19225135-4	2009	We developed a single-tube multiplex TaqMan (mERPR+HER2) assay to quantitate mRNA levels of ER, PR, HER2, and two housekeeping genes for breast cancer formalin-fixed, paraffin-embedded sections.	Formaldehyde	151-159	erb-b2 receptor tyrosine kinase 2	Homo sapiens	51-55
19225135-4	2009	We developed a single-tube multiplex TaqMan (mERPR+HER2) assay to quantitate mRNA levels of ER, PR, HER2, and two housekeeping genes for breast cancer formalin-fixed, paraffin-embedded sections.	Formaldehyde	151-159	estrogen receptor 1	Homo sapiens	46-48
19225135-4	2009	We developed a single-tube multiplex TaqMan (mERPR+HER2) assay to quantitate mRNA levels of ER, PR, HER2, and two housekeeping genes for breast cancer formalin-fixed, paraffin-embedded sections.	Formaldehyde	151-159	progesterone receptor	Homo sapiens	48-50
19052772-0	2009	Vinculin and cellular retinol-binding protein-1 are markers for quiescent and activated hepatic stellate cells in formalin-fixed paraffin embedded human liver.	Formaldehyde	114-122	retinol binding protein 1	Homo sapiens	13-47
19049879-6	2009	The expression of MyD88 after challenge with formalin-inactivated Gram-negative bacterium Vibrio parahaemolyticus was tested in blood, spleen and liver.	Formaldehyde	45-53	myeloid differentiation primary response protein MyD88	Larimichthys crocea	18-23
19462894-2	2009	METHODS: The expression of Maspin, VEGF, heparanase gene was detected by immunohistochemistry in formalin-fixed, paraffin-embedded specimens of normal ovaries (n=31) and epithelial ovarian cancers (n=35).	Formaldehyde	97-105	serpin family B member 5	Homo sapiens	27-33
19116162-5	2009	In behavioral studies, administration of Ang II (100 pmol) in the CVLM gave rise to hyperalgesia in both the tail-flick and formalin tests.	Formaldehyde	124-132	angiotensinogen	Homo sapiens	41-47
19100838-8	2009	Injection of cod with formalin-killed Vibrio anguillarum also increased IFN-gamma expression in head kidney, but to a much lesser extent than poly I:C. The gene expression results thus indicate a role for IFN-gamma in innate immune response against both virus and bacteria in Atlantic cod.	Formaldehyde	22-30	interferon gamma	Homo sapiens	72-81
19100838-8	2009	Injection of cod with formalin-killed Vibrio anguillarum also increased IFN-gamma expression in head kidney, but to a much lesser extent than poly I:C. The gene expression results thus indicate a role for IFN-gamma in innate immune response against both virus and bacteria in Atlantic cod.	Formaldehyde	22-30	interferon gamma	Homo sapiens	205-214
18988640-2	2009	Here, the authors detected the PAX3/7-FKHR fusion transcripts in 17 formalin-fixed, paraffin-embedded RMSs and 26 other SRCTs using one-step RT-PCR.	Formaldehyde	68-76	paired box 3	Homo sapiens	31-35
18988640-2	2009	Here, the authors detected the PAX3/7-FKHR fusion transcripts in 17 formalin-fixed, paraffin-embedded RMSs and 26 other SRCTs using one-step RT-PCR.	Formaldehyde	68-76	forkhead box O1	Homo sapiens	38-42
19091469-12	2009	), an "anxioselective" benzodiazepine site agonist with preferential activity at alpha2/alpha3 subunits, significantly reduced formalin-induced flinching in wild-type mice.	Formaldehyde	127-135	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	81-94
19036072-8	2009	Further, IAP induces partial aggregation of formaldehyde-fixed platelets.	Formaldehyde	44-56	islet amyloid polypeptide	Homo sapiens	9-12
18845658-6	2009	Proton Density-weighted images of this formalin-fixed material were acquired at 4.7 Tesla before the tissue was sectioned and stained for Myelin Basic Protein.	Formaldehyde	39-47	myelin basic protein	Homo sapiens	138-158
19538887-2	2009	METHODS: Immunohistochemistry was performed to detect the expression of THY1 gene in formalin-fixed, paraffin-embedded specimens of normal ovaries (n = 25), ovarian serous cystadenoma (n = 25), and serous cystadenocarcinoma (n = 53).	Formaldehyde	85-93	Thy-1 cell surface antigen	Homo sapiens	72-76
18550277-0	2009	A comparative study of natural, formaldehyde-treated and copolymer-grafted orange peel for Pb(II) adsorption under batch and continuous mode.	Formaldehyde	32-44	submaxillary gland androgen regulated protein 3B	Homo sapiens	91-97
19015000-3	2009	CD45 and MHC class I were upregulated in the activated microglia, which was evident on day 3 with the peak expression on day 7 following peripheral formalin injection.	Formaldehyde	148-156	protein tyrosine phosphatase, receptor type, C	Rattus norvegicus	0-4
18486530-3	2009	beta-Catenin accumulation was examined by immunohistochemistry in formalin-fixed, paraffin-embedded samples of six ameloblastomas and eight OCs.	Formaldehyde	66-74	catenin beta 1	Homo sapiens	0-12
19015000-5	2009	These results, for the first time, indicate that peripheral formalin injection can induce phenotypic changes of microglia with distinct upregulation of CD45 and MHC class I antigen.	Formaldehyde	60-68	protein tyrosine phosphatase, receptor type, C	Rattus norvegicus	152-156
19015000-5	2009	These results, for the first time, indicate that peripheral formalin injection can induce phenotypic changes of microglia with distinct upregulation of CD45 and MHC class I antigen.	Formaldehyde	60-68	RT1 class I, locus A3	Rattus norvegicus	161-180
18815565-2	2009	Tumor tissues are formalin fixed and paraffin embedded (FFPE) for histopathologic evaluation, making the development of an antibody against c-MET that accurately and reproducibly detects the protein in FFPE samples an urgent need.	Formaldehyde	18-26	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	140-145
19003793-10	2009	Formalin testing evoked c-fos expression in these pontospinal neurons, suggesting that they were nociresponsive (A5-21%, LC-16%, and A7-26%, n = 8).	Formaldehyde	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	24-29
19818222-9	2009	A subgroup of tumors particularly rich in GD3 could be detected on deparaffinized sections after standard formaldehyde fixation.	Formaldehyde	106-118	GRDX	Homo sapiens	42-45
18845121-2	2009	They can be oxidized by semicarbazide-sensitive amine oxidase (SSAO), leading to the production of toxic aldehydes such as formaldehyde and methylglyoxal as well as hydrogen peroxide and ammonia.	Formaldehyde	123-135	amine oxidase copper containing 2	Homo sapiens	24-61
18845121-2	2009	They can be oxidized by semicarbazide-sensitive amine oxidase (SSAO), leading to the production of toxic aldehydes such as formaldehyde and methylglyoxal as well as hydrogen peroxide and ammonia.	Formaldehyde	123-135	amine oxidase copper containing 2	Homo sapiens	63-67
19419937-4	2009	The expression of Fhit protein was assessed by means of the immunohistochemical method (avidin-biotin-streptavidin) in the sections fixed in formalin and embedded in paraffin, using rabbit polyclonal antiFhit antibody (Abcam, UK) at 1: 200.	Formaldehyde	141-149	fragile histidine triad diadenosine triphosphatase	Homo sapiens	18-22
19697624-3	2009	METHODS: The expression of ERBB2 has been analyzed immunohistochemically in formalin-fixed paraffin-embedded primary uterine sarcomas (n = 11).	Formaldehyde	76-84	erb-b2 receptor tyrosine kinase 2	Homo sapiens	27-32
18849615-0	2009	Molecular events in human T cells treated with diesel exhaust particles or formaldehyde that underlie their diminished interferon-gamma and interleukin-10 production.	Formaldehyde	75-87	interferon gamma	Homo sapiens	119-135
18849615-0	2009	Molecular events in human T cells treated with diesel exhaust particles or formaldehyde that underlie their diminished interferon-gamma and interleukin-10 production.	Formaldehyde	75-87	interleukin 10	Homo sapiens	140-154
18957334-4	2009	The monoclonal antibody anti-TNFalpha (25 and 50 pg/lip) significantly inhibited the second phase of formalin-induced nociceptive behavior, while the first phase remained unaltered.	Formaldehyde	101-109	tumor necrosis factor	Rattus norvegicus	29-37
19053567-0	2008	Photodissociation dynamics of formaldehyde initiated at the T1/S0 minimum energy crossing configurations.	Formaldehyde	30-42	interleukin 1 receptor like 1	Homo sapiens	60-65
18957334-7	2009	In addition, the systemic pretreatment with the preferential inhibitor of TNFalpha synthesis thalidomide (25 and 50 mg/kg, p.o) promoted a marked reduction of the first and second phases of formalin-evoked nociception.	Formaldehyde	190-198	tumor necrosis factor	Rattus norvegicus	74-82
18957334-8	2009	The local administration of the monoclonal antibody anti-TNFalpha (25 and 50 pg/lip) or infliximab (50 pg/lip) markedly reduced the plasma extravasation induced by formalin.	Formaldehyde	164-172	tumor necrosis factor	Rattus norvegicus	57-65
19309232-8	2009	The aim of our study was to establish the methods for rapid and sensitive detection of KRAS mutation status in formalin fixed paraffin embedded (FFPE) tissues DNA.	Formaldehyde	111-119	KRAS proto-oncogene, GTPase	Homo sapiens	87-91
19247482-3	2009	METHODOLOGY: Using a unique series of mutations in the DNA binding protein MeCP2, we show that in vivo interactions lasting less than 5 seconds are invisible in the microscope after formaldehyde fixation, though they are obvious in live cells.	Formaldehyde	182-194	methyl-CpG binding protein 2	Homo sapiens	75-80
19538866-2	2009	METHODS: The mRNA expression of ERCC1 in formalin-fixed paraffin-embedded primary tumor specimens was measured by real-time quantitative reverse transcriptase polymerase chain reaction.	Formaldehyde	41-49	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	32-37
19091468-4	2009	Intraplantar PACAP-38 (0.2nmol) injection inhibited carrageenan-evoked inflammatory mechanical allodynia, mild heat injury-induced thermal hyperalgesia, as well as nocifensive behaviors in the early and late phases of the formalin test in rats.	Formaldehyde	222-230	adenylate cyclase activating polypeptide 1	Rattus norvegicus	13-18
19240792-6	2009	ASB-PCR can be used for detection of germ line or somatic mutations in either DNA or RNA extracted from any type of tissue, including formalin-fixed paraffin-embedded tumor specimens.	Formaldehyde	134-142	arylsulfatase B	Homo sapiens	0-3
19366057-2	2009	METHODS AND STUDY DESIGN: We carried out an immunohistochemical assay for CK5/6 and CK17 markers on formalin-fixed invasive carcinoma samples from 112 patients who were diagnosed between 2000 and 2002.	Formaldehyde	100-108	keratin 5	Homo sapiens	74-79
19116018-4	2008	METHODS: We analyzed the mRNA expression of CDC6, CDT1, MCM2 and CDC45 in formalin-fixed, paraffin-embedded benign and malignant tongue tissues using quantitative real-time PCR followed by statistical analysis.	Formaldehyde	74-82	cell division cycle 45	Homo sapiens	65-70
18930743-9	2008	Subtoxic concentration of formaldehyde decreased the expression of tyrosine hydroxylase, the limiting factor in dopamine synthesis.	Formaldehyde	26-38	tyrosine hydroxylase	Rattus norvegicus	67-87
19074874-5	2008	Increased expression of these enzymes was paralleled by an elevated tolerance of K-ras mutants against the cytotoxic potential of hydrogen peroxide and formaldehyde as well as an altered redox status based on enhanced intracellular glutathione (GSH) levels indicating an improved detoxification potential of defined K-ras transfectants, whereas down-regulation by RNA interference of candidate proteins reversed the tolerance against these compounds.	Formaldehyde	152-164	KRAS proto-oncogene, GTPase	Homo sapiens	81-86
18852032-9	2008	This convergence of effects strengthens the proposal that the network of medial septal cholinergic neurons and hippocampal GABAergic interneurons influence formalin pain-induced CA1 pyramidal cell suppression.	Formaldehyde	156-164	carbonic anhydrase 1	Rattus norvegicus	178-181
18852032-1	2008	It has been hypothesized that intra-hippocampal GABAergic inhibitory interneurons mediate formalin pain-induced suppression of dorsal hippocampal CA1 pyramidal cell discharge.	Formaldehyde	90-98	carbonic anhydrase 1	Rattus norvegicus	146-149
18852032-6	2008	However, dorsal-bicuculline disinhibited the local CA1 interneurons that were strongly excited on injection of formalin.	Formaldehyde	111-119	carbonic anhydrase 1	Rattus norvegicus	51-54
19087271-5	2008	C-erbB2 gene expression was analyzed in 30 different human tissue samples of primary invasive breast cancer, following formalin fixation and subsequent paraffin-embedding.	Formaldehyde	119-127	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-7
19011746-3	2008	By oxidation of HMGSH, the spontaneous glutathione adduct of formaldehyde, ADH3 is implicated in the detoxification of formaldehyde.	Formaldehyde	61-73	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	75-79
19007111-3	2008	The metabolically released formaldehyde from the prodrugs was the dominant factor affecting cell viability by a ROS-dependent mechanism and was responsible for rapid phosphorylation of H2AX, suppression of the cell survival protein c-myc, and transient elevation in the expression of p21.	Formaldehyde	27-39	H2A.X variant histone	Homo sapiens	185-189
19007111-3	2008	The metabolically released formaldehyde from the prodrugs was the dominant factor affecting cell viability by a ROS-dependent mechanism and was responsible for rapid phosphorylation of H2AX, suppression of the cell survival protein c-myc, and transient elevation in the expression of p21.	Formaldehyde	27-39	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	232-237
19007111-3	2008	The metabolically released formaldehyde from the prodrugs was the dominant factor affecting cell viability by a ROS-dependent mechanism and was responsible for rapid phosphorylation of H2AX, suppression of the cell survival protein c-myc, and transient elevation in the expression of p21.	Formaldehyde	27-39	H3 histone pseudogene 16	Homo sapiens	284-287
18846040-9	2008	Finally, the effects of dexmedetomidine on formalin-induced Fos expression were assessed in the dorsal horn.	Formaldehyde	43-51	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	60-63
18846040-13	2008	On the other hand, both dexmedetomidine and morphine diminished the formalin-induced Fos activation.	Formaldehyde	68-76	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	85-88
18846040-14	2008	The effect of dexmedetomidine on formalin-induced Fos activation was reversed by BRL44408, but not ARC239.	Formaldehyde	33-41	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	50-53
19011746-3	2008	By oxidation of HMGSH, the spontaneous glutathione adduct of formaldehyde, ADH3 is implicated in the detoxification of formaldehyde.	Formaldehyde	119-131	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	75-79
18805787-5	2008	Intrathecal application of S1P or sphinganine 1-phosphate (dihydro-S1P) reduced the pain-related (nociceptive) behavior in the formalin assay.	Formaldehyde	127-135	sphingosine-1-phosphate receptor 1	Mus musculus	27-30
18382348-1	2008	Detection of the tumor-specific fusion gene, FUS-CREB3L2, is useful in the diagnosis of low-grade fibromyxoid sarcoma (LGFMS), especially by reverse transcription (RT)-polymerase chain reaction (PCR) using formalin-fixed, paraffin-embedded (FFPE) tumor tissues.	Formaldehyde	206-214	cAMP responsive element binding protein 3 like 2	Homo sapiens	49-56
18931652-7	2008	Molecular analysis for the D816V KIT mutation was performed on formalin-fixed paraffin-embedded sections.	Formaldehyde	63-71	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	33-36
19011637-4	2008	We show that a peptide consisting of amino acids 40-49 of Src fused to the protein transduction domain of the HIV Tat protein (Src40-49Tat) prevented pain behaviors induced by intraplantar formalin and reversed pain hypersensitivity produced by intraplantar injection of complete Freund"s adjuvant or by peripheral nerve injury.	Formaldehyde	189-197	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	58-61
19056857-4	2008	PATIENTS AND METHODS: We analyzed KRAS codon 12 and 13 mutations from formalin-fixed sections of 107 CRC primaries and related metastases.	Formaldehyde	70-78	KRAS proto-oncogene, GTPase	Homo sapiens	34-38
18755547-8	2008	Control rats treated with the KCC2 blocker DIOA, mimicked diabetes by showing increased formalin-evoked flinching and diminished rate- dependent depression.	Formaldehyde	88-96	solute carrier family 12 member 5	Rattus norvegicus	30-34
18824219-5	2008	Intrathecal injection of 26RFa significantly decreased the frequency of agitation behaviors induced by paw formalin injection, and attenuated the level of mechanical allodynia induced by paw carrageenan injection, in a dose dependent manner at doses between 0.01 and 10 microg.	Formaldehyde	107-115	pyroglutamylated RFamide peptide	Rattus norvegicus	25-30
18824219-7	2008	An immunohistochemical study revealed that GPR103-like immunoreactivity (LI) was observed in the superficial layers of spinal dorsal horn, that QRFP-LI was observed in the dorsal root ganglion and that intrathecal 26RFa suppressed the expression of Fos-LI induced by paw formalin injection in the superficial layers of the spinal dorsal horn.	Formaldehyde	271-279	pyroglutamylated RFamide peptide	Rattus norvegicus	214-219
18824219-8	2008	These data suggested that spinally applied 26RFa may modulate spinal sensitization induced by paw formalin injection or paw carrageenan injection.	Formaldehyde	98-106	pyroglutamylated RFamide peptide	Rattus norvegicus	43-48
18382348-0	2008	DNA-based polymerase chain reaction for detecting FUS-CREB3L2 in low-grade fibromyxoid sarcoma using formalin-fixed, paraffin-embedded tissue specimens.	Formaldehyde	101-109	FUS RNA binding protein	Homo sapiens	50-53
18382348-1	2008	Detection of the tumor-specific fusion gene, FUS-CREB3L2, is useful in the diagnosis of low-grade fibromyxoid sarcoma (LGFMS), especially by reverse transcription (RT)-polymerase chain reaction (PCR) using formalin-fixed, paraffin-embedded (FFPE) tumor tissues.	Formaldehyde	206-214	FUS RNA binding protein	Homo sapiens	45-48
18800350-4	2008	K-ras mutation was detected by cycle sequencing of polymerase chain reaction (PCR)-amplified DNA, isolated from formalin-fixed, paraffin-embedded lung tumors.	Formaldehyde	112-120	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	0-5
19054131-6	2008	With low formalin (0.8% or 1.6%), Gat1-Myc(13) became more nuclear, and with higher concentrations (5.6%), it became more cytoplasmic.	Formaldehyde	9-17	Gat1p	Saccharomyces cerevisiae S288C	34-38
19054131-8	2008	Interestingly, the high concentration of formalin had no demonstrable effect when the GATA factors were completely nuclear, i.e. after rapamycin (Gat1-Myc(13)) or Msx (Gln3-Myc(13)) treatment.	Formaldehyde	41-49	Gat1p	Saccharomyces cerevisiae S288C	146-150
19054131-8	2008	Interestingly, the high concentration of formalin had no demonstrable effect when the GATA factors were completely nuclear, i.e. after rapamycin (Gat1-Myc(13)) or Msx (Gln3-Myc(13)) treatment.	Formaldehyde	41-49	nitrogen-responsive transcriptional regulator GLN3	Saccharomyces cerevisiae S288C	168-172
18655205-3	2008	treatment with a sigma-1 receptor antagonist reduced formalin-induced pain behavior.	Formaldehyde	53-61	sigma non-opioid intracellular receptor 1	Mus musculus	17-33
18753128-6	2008	MELC analysis was performed with 37 different antibodies or fluorescence tags on spinal cord slices and led to the identification of 1390 PAM-related motifs that distinguish untreated and formalin-treated spinal cords.	Formaldehyde	188-196	MYC binding protein 2	Rattus norvegicus	138-141
19206397-6	2008	In a triplex assay on formalin-fixed human prostate tissue, two antibody-conjugated COINs and a conventional fluorophore are used to image expression of prostate-specific antigen, cytokeratin-18, and DNA.	Formaldehyde	22-30	kallikrein related peptidase 3	Homo sapiens	153-194
18822355-5	2008	Following exposure to repeated injections of 5% formalin, we detected Bax, Bcl-2, pro-caspase and activated caspase-3 proteins using immunoblotting.	Formaldehyde	48-56	BCL2 associated X, apoptosis regulator	Rattus norvegicus	70-73
18822355-5	2008	Following exposure to repeated injections of 5% formalin, we detected Bax, Bcl-2, pro-caspase and activated caspase-3 proteins using immunoblotting.	Formaldehyde	48-56	caspase 3	Rattus norvegicus	108-117
18805787-5	2008	Intrathecal application of S1P or sphinganine 1-phosphate (dihydro-S1P) reduced the pain-related (nociceptive) behavior in the formalin assay.	Formaldehyde	127-135	sphingosine-1-phosphate receptor 1	Mus musculus	67-70
18752656-9	2008	Finally, the bone deformity-rescued CNP-KO mice displayed a decreased response to formalin-induced pain compared to wild-type.	Formaldehyde	82-90	natriuretic peptide type C	Mus musculus	36-39
24855511-5	2008	The localization of injected-CD34+ cells was assessed on formalin-fixed, paraffin-embedded mouse skin samples by in situ hybridization technique.	Formaldehyde	57-65	CD34 antigen	Mus musculus	29-33
18612800-1	2008	The aim of the present study was to investigate the localization and distribution of the putative brain tumour stem cell marker CD133 in formalin fixed paraffin embedded astrocytomas.	Formaldehyde	137-145	prominin 1	Homo sapiens	128-133
18946301-1	2008	BACKGROUND: Selective blockade of spinal sigma(1) receptors (Sig-1R) suppresses nociceptive behaviors in the mouse formalin test.	Formaldehyde	115-123	sigma non-opioid intracellular receptor 1	Mus musculus	61-67
19130735-0	2008	Reliability and reproducibility of PCR-based testing of O6-methylguanine-DNA methyltransferase gene (MGMT) promoter methylation status in formalin-fixed and paraffin-embedded neurosurgical biopsy specimens.	Formaldehyde	138-146	O-6-methylguanine-DNA methyltransferase	Homo sapiens	56-99
19130735-0	2008	Reliability and reproducibility of PCR-based testing of O6-methylguanine-DNA methyltransferase gene (MGMT) promoter methylation status in formalin-fixed and paraffin-embedded neurosurgical biopsy specimens.	Formaldehyde	138-146	O-6-methylguanine-DNA methyltransferase	Homo sapiens	101-105
19130735-1	2008	OBJECTIVE: To analyze the reliability and reproducibility of PCR-based testing of O6-methylguanine-DNA methyltransferase gene (MGMT) promoter methylation status in formalin-fixed and paraffin-embedded (FFPE) neurosurgical biopsy specimens.	Formaldehyde	164-172	O-6-methylguanine-DNA methyltransferase	Homo sapiens	82-125
19130735-1	2008	OBJECTIVE: To analyze the reliability and reproducibility of PCR-based testing of O6-methylguanine-DNA methyltransferase gene (MGMT) promoter methylation status in formalin-fixed and paraffin-embedded (FFPE) neurosurgical biopsy specimens.	Formaldehyde	164-172	O-6-methylguanine-DNA methyltransferase	Homo sapiens	127-131
18681860-3	2008	DESIGN: We investigated the expression of CLA using the HECA-452 antibody on paraffin-embedded, formalin-fixed tissue in a variety of reactive, neoplastic and preneoplastic cutaneous lymphoid infiltrates of T- and B-cell derivation.	Formaldehyde	96-104	selectin P ligand	Homo sapiens	42-45
18711169-2	2008	Aims of the present study were to establish determination of PITX2 methylation for routine analysis in formalin-fixed paraffin-embedded (FFPE) breast cancer tissue and to test PITX2 DNA methylation as a biomarker for outcome prediction in an independent patient cohort.	Formaldehyde	103-111	paired like homeodomain 2	Homo sapiens	61-66
18772885-2	2008	A proteomic analysis of mitotic chromosome scaffolds led to the identification of CENP-V, a novel kinetochore protein related to a bacterial enzyme that detoxifies formaldehyde, a by-product of histone demethylation in eukaryotic cells.	Formaldehyde	164-176	centromere protein V	Homo sapiens	82-88
18706764-7	2008	Furthermore, in formalin inflammation pain model, pre-inhibition of EphBs receptors by the injection of EphB1-Fc reduces pain behavior, which is accompanied by the decreased expression of peripheral p-p38, pERK and pJNK.	Formaldehyde	16-24	Eph receptor B1	Mus musculus	104-109
18954467-3	2008	Recent reports have suggested that TRPA1 may play an important role in acute formalin and CFA induced pain.	Formaldehyde	77-85	transient receptor potential cation channel subfamily A member 1	Homo sapiens	35-40
18851757-6	2008	Unlike WT mice, PSD-93 knockout mice also showed marked losses of NMDAR-dependent morphine analgesic tolerance and associated abnormal sensitivity in response to mechanical, noxious thermal, and formalin-induced inflammatory stimuli after repeated morphine injection.	Formaldehyde	195-203	discs large MAGUK scaffold protein 2	Mus musculus	16-22
18582519-8	2008	O395-N1-E1 induces anti-CTB IgG and vibriocidal antibodies in mice immunized with two doses of formalin killed whole cells.	Formaldehyde	95-103	phosphate cytidylyltransferase 1, choline, beta isoform	Mus musculus	24-27
18984785-4	2008	COX-2 expression was assessed in formalin-fixed paraffin-embedded tissues from 14 sarcoids, 11 melanomas, and 37 SCC that represent various anatomic sites by using standard immunohistochemical methods.	Formaldehyde	33-41	prostaglandin-endoperoxide synthase 2	Equus caballus	0-5
19173831-2	2008	METHODS: Immunohistochemistry (IHC) was used to detect the expression of DPPIV protein in 378 formalin-fixed paraffin-embedded EOC tissue samples.	Formaldehyde	94-102	dipeptidyl peptidase 4	Homo sapiens	73-78
18771711-17	2008	acetic acid injection, respectively, and (2) the alteration of pERK and pCaMKIIalpha in nociceptive processing induced by formalin, glutamate, pro-inflammatory cytokines and acetic acid was modulated in a different manner.	Formaldehyde	122-130	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	63-67
19256750-9	2008	Immunohistochemical analysis of p16INK4A was performed on 53 formalin fixed and paraffin embedded samples of various stages of cervical neoplastic lesions.	Formaldehyde	61-69	cyclin dependent kinase inhibitor 2A	Homo sapiens	32-40
18774496-3	2008	We used immunohistochemistry to examine the distribution and expression pattern of MCM2 on formalin-fixed paraffin-embedded tissue sections of benign (n = 30) and malignant breast tissue (n = 70) (IDC 56, DCIS 4, ILC 2, nonductal 4, mixed type 4).	Formaldehyde	91-99	minichromosome maintenance complex component 2	Homo sapiens	83-87
18925697-3	2008	We determined the expression of MMP-2 in 152 formalin-fixed, paraffin embedded specimens of Duke"s B colon carcinomas by immunohistochemical analysis using MMP-2 monoclonal antibody.	Formaldehyde	45-53	matrix metallopeptidase 2	Homo sapiens	32-37
18637015-3	2008	Immunocytochemistry and histochemistry were performed to determine the effects of emulsified isoflurane on formalin-induced changes in Fos-like immunoreactive (Fos-LI)- and nicotinamide adenine dinucleotide phosphatediaphorase (NADPH-d)-positive neurons, respectively.	Formaldehyde	107-115	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	135-138
18637015-3	2008	Immunocytochemistry and histochemistry were performed to determine the effects of emulsified isoflurane on formalin-induced changes in Fos-like immunoreactive (Fos-LI)- and nicotinamide adenine dinucleotide phosphatediaphorase (NADPH-d)-positive neurons, respectively.	Formaldehyde	107-115	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	160-163
18637015-5	2008	Furthermore, Fos-LI- and NADPH-d-positive neurons were mainly found in the ipsilateral dorsal horn after injection of formalin, some of which were Fos-LI/NADPH-d double-labelled neurons.	Formaldehyde	118-126	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	13-16
18637015-5	2008	Furthermore, Fos-LI- and NADPH-d-positive neurons were mainly found in the ipsilateral dorsal horn after injection of formalin, some of which were Fos-LI/NADPH-d double-labelled neurons.	Formaldehyde	118-126	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	147-150
18925698-4	2008	Immunohistochemistry was performed on formalin-fixed, paraffin-embedded tissue by antibody p27 and cyclin D1.	Formaldehyde	38-46	interferon alpha inducible protein 27	Homo sapiens	91-94
18925698-4	2008	Immunohistochemistry was performed on formalin-fixed, paraffin-embedded tissue by antibody p27 and cyclin D1.	Formaldehyde	38-46	cyclin D1	Homo sapiens	99-108
18785805-10	2008	This technology forms the basis for the Previstagetrade mark GCC Colorectal Cancer Staging Test encompassing a proprietary multiplex qRT-PCR assay compatible with formalin-fixed, paraffin-embedded lymph nodes for detecting occult metastases.	Formaldehyde	163-171	guanylate cyclase 2C	Homo sapiens	61-64
18619646-2	2008	Expression of beta-catenin was analyzed by immunohistochemistry in formalin-fixed decalcified bone marrow biopsy specimens from 52 chronic myeloproliferative disorder cases and 6 nonchronic myeloproliferative disorder bone marrows as controls.	Formaldehyde	67-75	catenin beta 1	Homo sapiens	14-26
18667792-7	2008	Following hCG, there was a biphasic increase in testosterone concentration with maxima between 1 and 3 h and between 24 and 72 h, and there was a monophasic increase in the total estrogen concentration with a maximum between 6 and 24 h. At time 0, the total estrogen concentration correlated significantly with BFV (r=0.90; P&lt;0.05) but the testosterone concentration did not (P&gt;0.05).	Formaldehyde	311-314	chorionic gonadotropin subunit beta 5	Homo sapiens	10-13
18667792-9	2008	The total estrogen concentration, but not testosterone, correlated well with BFV after injection of hCG (P&lt;0.05).	Formaldehyde	77-80	chorionic gonadotropin subunit beta 5	Homo sapiens	100-103
18971621-1	2008	BACKGROUND: FISH and immunohistochemistry (IHC) on formalin-fixed paraffin embedded (FFPE) tissue are currently used in the clinical laboratory to determine HER2 status in invasive breast cancer patients.	Formaldehyde	51-59	erb-b2 receptor tyrosine kinase 2	Homo sapiens	157-161
18720326-7	2008	The positive detection of the SYT-SSX1 fusion transcripts with reverse-transcription polymerase chain reaction in formalin-fixed and paraffin-embedded tissue confirmed the synovial sarcoma diagnosis.	Formaldehyde	114-122	synaptotagmin 1	Homo sapiens	30-33
18758970-2	2008	Given that S1P(1) signaling could serve as a therapeutic target, we evaluate the expression of S1P(1) in formalin-fixed and paraffin-embedded sections from human tissues, using automated immunostainers (Ventana).	Formaldehyde	105-113	sphingosine-1-phosphate receptor 1	Homo sapiens	95-101
18720326-7	2008	The positive detection of the SYT-SSX1 fusion transcripts with reverse-transcription polymerase chain reaction in formalin-fixed and paraffin-embedded tissue confirmed the synovial sarcoma diagnosis.	Formaldehyde	114-122	SSX family member 1	Homo sapiens	34-38
18695911-10	2008	Moreover, IHC analysis is a reliable and useful modality of assessing the status of p-STAT3 expression in formalin-fixed samples.	Formaldehyde	106-114	signal transducer and activator of transcription 3	Homo sapiens	86-91
19102336-5	2008	The expression of PGP, GST-pi, Topo-II and LRP in formalin-fixed paraffin-embedded tissue sections was determined by a labelled streptavidin-biotin immunohistochemical technique, and the results were analyzed in correlation with clinicopathological data.	Formaldehyde	50-58	major vault protein	Homo sapiens	43-46
18718399-5	2008	In situ hybridization with the ALP probe was performed using formalin-fixed, paraffin-embedded tissue samples.	Formaldehyde	61-69	alkaline phosphatase, placental	Homo sapiens	31-34
18652435-1	2008	A novel, nonadiabatic reaction path for H2 + CO molecular dissociation of formaldehyde via an extended S1/S0 conical intersection seam has been mapped out using the CAS-SCF method with a full valence active space (10 electrons, 9 orbitals).	Formaldehyde	74-86	KIT ligand	Homo sapiens	169-172
20735955-4	2008	METHODS: The expression of BAG-1 was detected by real-time PCR in formalin-fixed, paraffin-embedded human lung cancer tissues of 156 cases.	Formaldehyde	66-74	BAG cochaperone 1	Homo sapiens	27-32
20735971-0	2008	[PML expression in lung carcinomas: analysis by RT-PCR in formalin-fixed and paraffin-embedded tissue.].	Formaldehyde	58-66	PML nuclear body scaffold	Homo sapiens	1-4
19066503-12	2008	A unique advantage of the SMRT array is that one can use DNA isolated from formalin fixed paraffin embedded samples.	Formaldehyde	75-83	nuclear receptor corepressor 2	Homo sapiens	26-30
18030472-9	2008	Formaldehyde-releasing prodrugs abrogated c-myc protein expression and elevated c-Jun and H2AX phosphorylation, N-acetylcysteine partially reversed these changes.	Formaldehyde	0-12	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	42-47
18412547-7	2008	Hence, considering the high cytosolic NAD(+)/NADH ratio, formaldehyde probably triggers ADH3-mediated GSNO reduction by enzyme-bound cofactor recycling and might result in a decrease in cellular S-NO (S-nitrosothiol) content in vivo.	Formaldehyde	57-69	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	88-92
18030472-9	2008	Formaldehyde-releasing prodrugs abrogated c-myc protein expression and elevated c-Jun and H2AX phosphorylation, N-acetylcysteine partially reversed these changes.	Formaldehyde	0-12	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	80-85
18030472-9	2008	Formaldehyde-releasing prodrugs abrogated c-myc protein expression and elevated c-Jun and H2AX phosphorylation, N-acetylcysteine partially reversed these changes.	Formaldehyde	0-12	H2A.X variant histone	Homo sapiens	90-94
18676747-3	2008	EXPERIMENTAL DESIGN: Expression of pRb2/p130 was evaluated by immunohistochemistry on formalin-fixed, paraffin-embedded sections in 41 STSs.	Formaldehyde	86-94	proline rich protein BstNI subfamily 2	Homo sapiens	35-39
18676747-10	2008	CONCLUSIONS: This study shows for the first time the potential prognostic value of pRb2/130 expression evaluated on formalin-fixed, paraffin-embedded sections in STSs patients.	Formaldehyde	116-124	proline rich protein BstNI subfamily 2	Homo sapiens	83-87
18413654-0	2008	FOXP3 immunohistochemistry on formalin-fixed paraffin-embedded tissue: poor correlation between different antibodies.	Formaldehyde	30-38	forkhead box P3	Homo sapiens	0-5
18413654-6	2008	This report describes the experience of using two commonly used monoclonal FOXP3 antibodies on formalin-fixed paraffin-embedded sections of different organs, including the cervix and vulva.	Formaldehyde	95-103	forkhead box P3	Homo sapiens	75-80
18474542-5	2008	METHODS: The expression of p-mTOR (Ser2448) was immunohistochemically assessed in a validated tissue microarray comprising triplicate tissue biopsy cores of 108 formalin-fixed, paraffin-embedded OSCCs.	Formaldehyde	161-169	mechanistic target of rapamycin kinase	Homo sapiens	27-33
18524486-5	2008	The expression of the immediate-early gene product Fos in the dorsal horn ipsilateral to formalin injection was similar between QUIS- and sham-lesioned rats.	Formaldehyde	89-97	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	51-54
19115622-0	2008	[Relationship between susceptibility of formaldehyde metabolism and genetic polymorphisms of ALDH2 and cytochrome P4502E1].	Formaldehyde	40-52	aldehyde dehydrogenase 2 family member	Homo sapiens	93-98
19115622-1	2008	OBJECTIVE: To study the relationship between occupational hazard susceptibility of formaldehyde and genetic polymorphisms of ALDH2 and CYP2E1.	Formaldehyde	83-95	aldehyde dehydrogenase 2 family member	Homo sapiens	125-130
19115622-1	2008	OBJECTIVE: To study the relationship between occupational hazard susceptibility of formaldehyde and genetic polymorphisms of ALDH2 and CYP2E1.	Formaldehyde	83-95	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	135-141
19115622-2	2008	METHODS: Genotypes of ALDH2 and CYP2E1 (Rsa I/Pst I site) of 107 subjects exposed to formaldehyde were determined with PCR-RFLP through testing peripheral blood lymphocytes, and the concentration of air formaldehyde in workplace and urine formic acid of the subjects were measured with HPLC.	Formaldehyde	85-97	aldehyde dehydrogenase 2 family member	Homo sapiens	22-27
19115622-2	2008	METHODS: Genotypes of ALDH2 and CYP2E1 (Rsa I/Pst I site) of 107 subjects exposed to formaldehyde were determined with PCR-RFLP through testing peripheral blood lymphocytes, and the concentration of air formaldehyde in workplace and urine formic acid of the subjects were measured with HPLC.	Formaldehyde	85-97	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	32-38
19115622-2	2008	METHODS: Genotypes of ALDH2 and CYP2E1 (Rsa I/Pst I site) of 107 subjects exposed to formaldehyde were determined with PCR-RFLP through testing peripheral blood lymphocytes, and the concentration of air formaldehyde in workplace and urine formic acid of the subjects were measured with HPLC.	Formaldehyde	85-97	sulfotransferase family 1A member 1	Homo sapiens	46-49
19115622-6	2008	Our data indicated that the formaldehyde metabolism of ALDH2 GG homozygotic genotype was more active than ALDH2 AA homozygotic genotype(the difference of the two mean rank was 13.30).	Formaldehyde	28-40	aldehyde dehydrogenase 2 family member	Homo sapiens	55-60
19115622-6	2008	Our data indicated that the formaldehyde metabolism of ALDH2 GG homozygotic genotype was more active than ALDH2 AA homozygotic genotype(the difference of the two mean rank was 13.30).	Formaldehyde	28-40	aldehyde dehydrogenase 2 family member	Homo sapiens	106-111
19115622-9	2008	CONCLUSION: The metabolism of formaldehyde in human body was related with the genotypes of ALDH2, but not with the CYP2E1 (Rsa I/Pst I) polymorphisms.	Formaldehyde	30-42	aldehyde dehydrogenase 2 family member	Homo sapiens	91-96
17976913-1	2008	Our previous work indicates that the intrathecal administration of neuropeptide Y (NPY) acts at its cognate receptors to reduce behavioral signs of nociception in several models of inflammatory pain, including the formalin test.	Formaldehyde	214-222	neuropeptide Y	Rattus norvegicus	83-86
17976913-6	2008	Either tactile stimulation of the hindpaw ipsilateral to nerve injury, or intraplantar injection of noxious formalin, increased the number of Fos-like immunoreactive profiles.	Formaldehyde	108-116	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	142-145
17976913-8	2008	We found that intrathecal NPY reduced both formalin- and SNI-induced Fos expression.	Formaldehyde	43-51	neuropeptide Y	Rattus norvegicus	26-29
17976913-8	2008	We found that intrathecal NPY reduced both formalin- and SNI-induced Fos expression.	Formaldehyde	43-51	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	69-72
18533197-3	2008	Immunocytochemistry of formalin perfused rats revealed distinct localization of PGAM1 in the endothelium of the capillaries and arteries of the brain, liver and kidneys.	Formaldehyde	23-31	phosphoglycerate mutase 1	Rattus norvegicus	80-85
17964723-1	2008	This study investigated the effect of haeme oxygenase-1 (HO-1) in nociception induced by formalin injection in the mice hind paw.	Formaldehyde	89-97	heme oxygenase 1	Mus musculus	38-55
17964723-1	2008	This study investigated the effect of haeme oxygenase-1 (HO-1) in nociception induced by formalin injection in the mice hind paw.	Formaldehyde	89-97	heme oxygenase 1	Mus musculus	57-61
17976913-1	2008	Our previous work indicates that the intrathecal administration of neuropeptide Y (NPY) acts at its cognate receptors to reduce behavioral signs of nociception in several models of inflammatory pain, including the formalin test.	Formaldehyde	214-222	neuropeptide Y	Rattus norvegicus	67-81
18563235-1	2008	The electrocatalytic activities and mechanisms of PtPb and PtBi ordered intermetallic phases towards formic acid, formaldehyde and methanol oxidation have been studied by DEMS and FTIRS, and the results compared to those for a pure polycrystalline platinum electrode.	Formaldehyde	114-126	protein tyrosine phosphatase receptor type B	Homo sapiens	50-54
18563235-6	2008	In contrast, CO(2) is the major product for formaldehyde and methanol oxidation at a PtPb electrode.	Formaldehyde	44-56	protein tyrosine phosphatase receptor type B	Homo sapiens	85-89
18563235-7	2008	The high current efficiency of CO(2) formation for methanol and formaldehyde oxidation at a PtPb electrode can be ascribed to the complete dehydrogenation of formaldehyde and formic acid due to electronic effects.	Formaldehyde	64-76	protein tyrosine phosphatase receptor type B	Homo sapiens	92-96
18563235-7	2008	The high current efficiency of CO(2) formation for methanol and formaldehyde oxidation at a PtPb electrode can be ascribed to the complete dehydrogenation of formaldehyde and formic acid due to electronic effects.	Formaldehyde	158-170	protein tyrosine phosphatase receptor type B	Homo sapiens	92-96
18556773-2	2008	Stratified therapy assignment of patients in prospective clinical trials according to tumor MGMT status requires a standardized diagnostic test, suitable for high-throughput analysis of small amounts of formalin-fixed, paraffin-embedded tumor tissue.	Formaldehyde	203-211	O-6-methylguanine-DNA methyltransferase	Homo sapiens	92-96
17912630-1	2008	BACKGROUND: The aims of this study were to define the distribution of caveolin 2 (CAV2) in frozen and formalin fixed, paraffin embedded (FFPE) normal breast samples and the significance of CAV2 expression in breast cancer.	Formaldehyde	102-110	caveolin 2	Homo sapiens	70-80
18780655-1	2008	AIM: To examine by means of immunohistochemistry the expression of the tumor suppressing gene p53 and gene p21 in cells of malignant melanoma of the uvea from formalin-paraffin material from patients, who were during the period 2000 - 2006 surgically treated due to malignant melanoma of the uvea at the Department of Ophthalmology in the University Hospital in Brno (Brunn), Czech Republic, E.U., and to correlate the results of the immunohistochemical detection with clinical signs of the tumor of each patient.	Formaldehyde	159-167	tumor protein p53	Homo sapiens	94-97
18780655-1	2008	AIM: To examine by means of immunohistochemistry the expression of the tumor suppressing gene p53 and gene p21 in cells of malignant melanoma of the uvea from formalin-paraffin material from patients, who were during the period 2000 - 2006 surgically treated due to malignant melanoma of the uvea at the Department of Ophthalmology in the University Hospital in Brno (Brunn), Czech Republic, E.U., and to correlate the results of the immunohistochemical detection with clinical signs of the tumor of each patient.	Formaldehyde	159-167	H3 histone pseudogene 16	Homo sapiens	107-110
18949741-3	2008	In an attempt to obtain new insight into the pathogenesis of OPN-associated breast carcinomas, an immunohistochemical panel with 17 primary antibodies including cytokeratins and key regulators of the cell cycle was performed in 100 formalin-fixed paraffin-embedded samples of invasive breast carcinomas.	Formaldehyde	232-240	secreted phosphoprotein 1	Homo sapiens	61-64
18413664-0	2008	Formaldehyde-activated Pixantrone is a monofunctional DNA alkylator that binds selectively to CpG and CpA doublets.	Formaldehyde	0-12	carboxypeptidase A1	Homo sapiens	102-105
18490897-0	2008	Modeling formalin fixation and histological processing with ribonuclease A: effects of ethanol dehydration on reversal of formaldehyde cross-links.	Formaldehyde	9-17	ribonuclease pancreatic	Bos taurus	60-74
18490897-2	2008	Our initial studies of single proteins, such as bovine pancreatic ribonuclease A (RNase A), in 10% buffered formalin solution revealed that upon removal of excess formaldehyde, monomeric RNase A exhibiting normal immunoreactivity could be recovered by heating at 60 degrees C for 30 min at pH 4.	Formaldehyde	108-116	ribonuclease pancreatic	Bos taurus	82-89
18490897-2	2008	Our initial studies of single proteins, such as bovine pancreatic ribonuclease A (RNase A), in 10% buffered formalin solution revealed that upon removal of excess formaldehyde, monomeric RNase A exhibiting normal immunoreactivity could be recovered by heating at 60 degrees C for 30 min at pH 4.	Formaldehyde	108-116	ribonuclease pancreatic	Bos taurus	187-194
18490897-2	2008	Our initial studies of single proteins, such as bovine pancreatic ribonuclease A (RNase A), in 10% buffered formalin solution revealed that upon removal of excess formaldehyde, monomeric RNase A exhibiting normal immunoreactivity could be recovered by heating at 60 degrees C for 30 min at pH 4.	Formaldehyde	163-175	ribonuclease pancreatic	Bos taurus	187-194
18413664-3	2008	In vitro transcriptional analysis has now established that formaldehyde-activated pixantrone generates covalent adducts selectively at discrete CpG or CpA dinucleotides, suggesting that the activated complex binds to guanine or cytosine (or both) bases.	Formaldehyde	59-71	carboxypeptidase A1	Homo sapiens	151-154
18483367-5	2008	Using immunohistochemical techniques, we analyzed the expressions of IGF-IR, EGFR, and HER2 on formalin-fixed paraffin-embedded specimens of surgically removed primary tumors.	Formaldehyde	95-103	insulin like growth factor 1 receptor	Homo sapiens	69-75
18942024-6	2008	The levels of SOD and GSH-Px decreased significantly, whereas the level of MDA significantly increased in animals treated with formaldehyde compared with the controls.	Formaldehyde	127-139	glutathione peroxidase 1	Rattus norvegicus	22-28
18549486-7	2008	P311-/- mice showed normal heat and mechanical sensitivity, as well as normal formalin-induced inflammatory pain.	Formaldehyde	78-86	neuronal regeneration related protein	Mus musculus	0-4
18549486-8	2008	In contrast, the formalin-induced avoidance behavior, which reflects pain-related negative emotion, was significantly attenuated in P311-/- mice relative to the control mice.	Formaldehyde	17-25	neuronal regeneration related protein	Mus musculus	132-136
17874293-4	2008	Compared with normal ddY/DAO+ mice, ddY/DAO(- )mice showed significantly prolonged tail withdrawal latency in the tail flick test and licking/jumping latency in the hot-plate test, as well as significantly reduced duration of licking/biting in the late phase of the formalin test and the number of abdominal writhing in the acetic acid-induced writhing test.	Formaldehyde	266-274	D-amino acid oxidase	Mus musculus	40-43
18589866-5	2008	Here we describe the use of an antibody to human Pax5 in diagnostic pathology with formalin-fixed, paraffin-embedded mouse tissue.	Formaldehyde	83-91	paired box 5	Homo sapiens	49-53
18587209-5	2008	The detection and activity of two MMPs (2 and 9) were performed by immunohistochemistry in formalin-fixed, paraffin-embedded sections of odontogenic myxoma and immunofluorescence of the cultured cells and, by gelatin zymographic analysis of Mix1 conditioned media, respectively.	Formaldehyde	91-99	matrix metallopeptidase 2	Homo sapiens	34-38
18686341-5	2008	METHODS: We examined the expression of TKTL1 and p-Akt in 80 formalin-fixed, paraffin-embedded cervical specimens: 20 benign cervical tissues, 20 low-grade squamous intraepithelial lesions, 20 high-grade intraepithelial lesions, and 20 invasive squamous cell carcinomas (ISCC).	Formaldehyde	61-69	transketolase like 1	Homo sapiens	39-44
18483367-5	2008	Using immunohistochemical techniques, we analyzed the expressions of IGF-IR, EGFR, and HER2 on formalin-fixed paraffin-embedded specimens of surgically removed primary tumors.	Formaldehyde	95-103	erb-b2 receptor tyrosine kinase 2	Homo sapiens	87-91
18410580-4	2008	The expression of FAS was determined by the standard immunoperoxidase technique in formalin-fixed and paraffin-embedded specimens and correlated with the clinicopathological characteristics of the tumors.	Formaldehyde	83-91	fatty acid synthase	Homo sapiens	18-21
18443954-5	2008	The expression of PGP, GST-pi, Topo-II and LRP in formalin-fixed paraffin-embedded tissue sections was determined by a labelled streptavidin-biotin immunohistochemical technique, and the results were analyzed in correlation with clinicopathological data.	Formaldehyde	50-58	major vault protein	Homo sapiens	43-46
18204431-7	2008	A monoclonal antibody against PPAR-gamma was used to stain formalin-fixed paraffin-embedded tissue.	Formaldehyde	59-67	peroxisome proliferator activated receptor gamma	Homo sapiens	30-40
18474293-0	2008	Detection of the TMPRSS2-ETS fusion gene in prostate carcinomas: retrospective analysis of 55 formalin-fixed and paraffin-embedded samples with clinical data.	Formaldehyde	94-102	transmembrane serine protease 2	Homo sapiens	17-24
18451222-8	2008	CONCLUSIONS: We developed and validated a five-gene reverse transcription PCR assay for MGI suitable for analyzing routine formalin-fixed paraffin-embedded clinical samples.	Formaldehyde	123-131	CMS1A1	Homo sapiens	88-91
18348286-2	2008	We have developed a high-throughput scanning assay with automatic calling to detect TP53 mutations in DNA from fresh frozen (FF) and formalin-fixed paraffin-embedded (FFPE) tissues.	Formaldehyde	133-141	tumor protein p53	Homo sapiens	84-88
18844117-4	2008	4% formaldehyde was used to fix the FLS and LAD-2 cells and then detect the IL-6 levels in the supernatant.	Formaldehyde	3-15	interleukin 6	Homo sapiens	76-80
18575327-2	2008	METHODS: The expressions of KAI1 protein in the formalin-fixed, paraffin-embedded specimens of 20 normal cervical epthelium, 15 cervical in situ carcinoma and 70 primary invasive cervical carcinoma were detected by immunohistochemistry SP.	Formaldehyde	48-56	CD82 molecule	Homo sapiens	28-32
18088105-10	2008	As a result, the triplet products CH2 + CH2O, H + CH2CHO and OH + C2H3 dominate over the singlet products CH3 + CHO, H2 + CH2CO, etc.	Formaldehyde	40-44	alien	Drosophila melanogaster	34-37
18379900-8	2008	RT-PCR using RNA extracted and purified from formalin-fixed paraffin-embedded pituitary adenoma specimens revealed MSX1 mRNA expressed in GH- and TSH-producing adenomas.	Formaldehyde	45-53	msh homeobox 1	Homo sapiens	115-119
17919838-5	2008	COX-2 expression was assessed immunohistochemically using a mouse monoclonal antibody on formalin-fixed paraffin-embedded tumor specimens taken before RT.	Formaldehyde	89-97	prostaglandin-endoperoxide synthase 2	Homo sapiens	0-5
21063301-2	2008	METHODS: Expression of the immediate-early gene c-fos and nitric oxide containing neurons one hour after unilateral formalin injection to the dorsal hind paw was investigated in rat lumbar spinal cord, using fos immunohistochemistry and NADPH-d histochemical techniques.	Formaldehyde	116-124	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	48-53
21063301-2	2008	METHODS: Expression of the immediate-early gene c-fos and nitric oxide containing neurons one hour after unilateral formalin injection to the dorsal hind paw was investigated in rat lumbar spinal cord, using fos immunohistochemistry and NADPH-d histochemical techniques.	Formaldehyde	116-124	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	50-53
21063301-5	2008	Approximately 20% of fos-immunoreactive neurons were NADPH-d positive ipsilateral to the formalin injection, whereas no double labeling was observed in the contralateral side.	Formaldehyde	89-97	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	21-24
18329177-2	2008	The time-course study (10 min, 30 min, 1 h, 2 h, and 10 h) showed that the POMC mRNA level significantly increases from 1 h after s.c. formalin injection and returns to the control level at 10 h. Intrathecal (i.t.)	Formaldehyde	135-143	pro-opiomelanocortin-alpha	Mus musculus	75-79
18329177-5	2008	We found that the POMC mRNA after s.c. formalin injection was located in the arcuate nucleus of the hypothalamus.	Formaldehyde	39-47	pro-opiomelanocortin-alpha	Mus musculus	18-22
18329177-8	2008	We also found that increased pERK1/2, pCaMKIIalpha and pIkappaB protein after s.c. formalin injection was mainly located in the arcuate nucleus of hypothalamus in which cells containing beta-endorphin after s.c. formalin injection also express pERK1/2, pCaMK-IIalpha and pIkappaB immunoreactivity.	Formaldehyde	83-91	pro-opiomelanocortin-alpha	Mus musculus	186-200
18329177-8	2008	We also found that increased pERK1/2, pCaMKIIalpha and pIkappaB protein after s.c. formalin injection was mainly located in the arcuate nucleus of hypothalamus in which cells containing beta-endorphin after s.c. formalin injection also express pERK1/2, pCaMK-IIalpha and pIkappaB immunoreactivity.	Formaldehyde	212-220	pro-opiomelanocortin-alpha	Mus musculus	186-200
18329177-9	2008	In addition, formalin-induced POMC mRNA expression was significantly reduced by 10 min, pretreatment with i.c.v.	Formaldehyde	13-21	pro-opiomelanocortin-alpha	Mus musculus	30-34
18341646-5	2008	Immunohistochemical staining for ADRP was performed in formalin-fixed, paraffin-embedded liver sections.	Formaldehyde	55-63	perilipin 2	Rattus norvegicus	33-37
17703974-1	2008	OBJECTIVES: The objective of this study was to examine the nature of interaction between cyclooxygenase-2 inhibitor meloxicam and inducible nitric oxide synthase inhibitor aminoguanidine in formalin-induced nociception in mice and the possible therapeutic advantage.	Formaldehyde	190-198	prostaglandin-endoperoxide synthase 2	Mus musculus	89-105
18249418-4	2008	Intrathecal sensory neuron-specific receptor agonists bovine adrenal medulla 8-22 and (tyr(6))-gamma2-msh-6-12 inhibit formalin-evoked nociception and neuronal fos-like immunoreactivity in the spinal cord of the rat.	Formaldehyde	119-127	Fos proto-oncogene, AP-1 transcription factor subunit	Bos taurus	160-163
18413102-6	2008	Formaldehyde release from MFR can explain most of the positive responses.	Formaldehyde	0-12	signal regulatory protein alpha	Homo sapiens	26-29
18258218-9	2008	The change in SP IR may have been due to an alteration of transport due to formalin injection, thus, transport was visualized by the accumulation of growth-associated protein 43 (GAP43) at the ligation site.	Formaldehyde	75-83	growth associated protein 43	Rattus norvegicus	149-177
18258218-9	2008	The change in SP IR may have been due to an alteration of transport due to formalin injection, thus, transport was visualized by the accumulation of growth-associated protein 43 (GAP43) at the ligation site.	Formaldehyde	75-83	growth associated protein 43	Rattus norvegicus	179-184
18292448-12	2008	CONCLUSIONS: A dual inhibitor of COX-1 and COX-2 suppressed both responses of formalin-evoked behaviors and FLI expression of whole laminae in the lumbar spinal cord.	Formaldehyde	78-86	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	33-38
18292448-12	2008	CONCLUSIONS: A dual inhibitor of COX-1 and COX-2 suppressed both responses of formalin-evoked behaviors and FLI expression of whole laminae in the lumbar spinal cord.	Formaldehyde	78-86	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	43-48
18248901-8	2008	Furthermore, PPG pretreatment attenuated the induction of c-Fos in spinal laminae I-II following injection of 5% formalin.	Formaldehyde	113-121	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	58-63
18300804-12	2008	Reverse transcription-polymerase chain reaction using RNA extracted from formalin-fixed, paraffin-embedded tissues demonstrated transcripts of the EWSR1-ATF1 (31/33) or EWSR1-CREB1 fusion gene (2/33).	Formaldehyde	73-81	EWS RNA binding protein 1	Homo sapiens	147-152
18300804-12	2008	Reverse transcription-polymerase chain reaction using RNA extracted from formalin-fixed, paraffin-embedded tissues demonstrated transcripts of the EWSR1-ATF1 (31/33) or EWSR1-CREB1 fusion gene (2/33).	Formaldehyde	73-81	activating transcription factor 1	Homo sapiens	153-157
18300804-12	2008	Reverse transcription-polymerase chain reaction using RNA extracted from formalin-fixed, paraffin-embedded tissues demonstrated transcripts of the EWSR1-ATF1 (31/33) or EWSR1-CREB1 fusion gene (2/33).	Formaldehyde	73-81	EWS RNA binding protein 1	Homo sapiens	169-174
18300804-12	2008	Reverse transcription-polymerase chain reaction using RNA extracted from formalin-fixed, paraffin-embedded tissues demonstrated transcripts of the EWSR1-ATF1 (31/33) or EWSR1-CREB1 fusion gene (2/33).	Formaldehyde	73-81	cAMP responsive element binding protein 1	Homo sapiens	175-180
17587322-2	2008	TLR5 expression was evaluated by immunohistochemistry (IHC) in 55 formalin-fixed paraffin-embedded cervical tissues; 10 normal cervical specimens, 9 low-grade cervical intraepithelial neoplasias (CINs), 12 high-grade CINs, and 24 invasive squamous cell carcinomas (ISCCs).	Formaldehyde	66-74	toll like receptor 5	Homo sapiens	0-4
18303407-3	2008	We established cyclin D1 expression level in 116 frozen and formalin-fixed, paraffin-embedded primary tumors from patients diagnosed with a variety of B-cell lymphoproliferative disorders.	Formaldehyde	60-68	cyclin D1	Homo sapiens	15-24
18303411-0	2008	Detection of FOXO1 (FKHR) gene break-apart by fluorescence in situ hybridization in formalin-fixed, paraffin-embedded alveolar rhabdomyosarcomas and its clinicopathologic correlation.	Formaldehyde	84-92	forkhead box O1	Homo sapiens	13-18
17998570-5	2008	However, significant negative correlation between staining result and formalin fixation was observed by blinded scoring of staining for CD45/LCA, CNPase, GFAP, and NeuN in brain specimens fixed by immersion and stored up to 10 years in 4% formalin solution at room temperature, independent of donor sex and postmortem interval.	Formaldehyde	70-78	protein tyrosine phosphatase receptor type C	Homo sapiens	136-140
17998570-5	2008	However, significant negative correlation between staining result and formalin fixation was observed by blinded scoring of staining for CD45/LCA, CNPase, GFAP, and NeuN in brain specimens fixed by immersion and stored up to 10 years in 4% formalin solution at room temperature, independent of donor sex and postmortem interval.	Formaldehyde	70-78	protein tyrosine phosphatase receptor type C	Homo sapiens	141-144
17998570-5	2008	However, significant negative correlation between staining result and formalin fixation was observed by blinded scoring of staining for CD45/LCA, CNPase, GFAP, and NeuN in brain specimens fixed by immersion and stored up to 10 years in 4% formalin solution at room temperature, independent of donor sex and postmortem interval.	Formaldehyde	70-78	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	146-152
17998570-5	2008	However, significant negative correlation between staining result and formalin fixation was observed by blinded scoring of staining for CD45/LCA, CNPase, GFAP, and NeuN in brain specimens fixed by immersion and stored up to 10 years in 4% formalin solution at room temperature, independent of donor sex and postmortem interval.	Formaldehyde	70-78	glial fibrillary acidic protein	Homo sapiens	154-158
17998570-5	2008	However, significant negative correlation between staining result and formalin fixation was observed by blinded scoring of staining for CD45/LCA, CNPase, GFAP, and NeuN in brain specimens fixed by immersion and stored up to 10 years in 4% formalin solution at room temperature, independent of donor sex and postmortem interval.	Formaldehyde	70-78	RNA binding fox-1 homolog 3	Homo sapiens	164-168
18096151-1	2008	The aim of the present study was to investigate the role of the spinal cord heme oxygenase (HO)-carbon monoxide (CO)-soluble guanylate cyclase (sGC)-cGMP pathway in nociceptive response of rats to the formalin experimental nociceptive model.	Formaldehyde	201-209	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	144-147
18192970-5	2008	However, by taking advantage of a technique which allows for multiple fluorescent labeling of formalin-fixed paraffin-embedded archival sections, we demonstrate unambiguously that endosialin is not expressed by the glioma endothelial cells but on closely associated perivascular cells.	Formaldehyde	94-102	CD248 molecule	Homo sapiens	180-190
32038776-0	2008	Elevated Levels of PDGF Receptor and MDM2 as Potential Biomarkers for Formaldehyde Intoxication.	Formaldehyde	70-82	MDM2 proto-oncogene	Homo sapiens	37-41
32038776-3	2008	Using polymerase chain reaction-based suppression subtractive hybridization, we recently identified 27 different formaldehyde-inducible genes including platelet-derived growth factor receptor alpha gene (PDGFRA) and mouse double minute 2 (MDM2) gene which were increased significantly in both formaldehyde-exposed human trachea cells, 680.	Formaldehyde	113-125	platelet derived growth factor receptor, alpha polypeptide	Mus musculus	152-197
32038776-3	2008	Using polymerase chain reaction-based suppression subtractive hybridization, we recently identified 27 different formaldehyde-inducible genes including platelet-derived growth factor receptor alpha gene (PDGFRA) and mouse double minute 2 (MDM2) gene which were increased significantly in both formaldehyde-exposed human trachea cells, 680.	Formaldehyde	113-125	platelet derived growth factor receptor, alpha polypeptide	Mus musculus	204-210
32038776-3	2008	Using polymerase chain reaction-based suppression subtractive hybridization, we recently identified 27 different formaldehyde-inducible genes including platelet-derived growth factor receptor alpha gene (PDGFRA) and mouse double minute 2 (MDM2) gene which were increased significantly in both formaldehyde-exposed human trachea cells, 680.	Formaldehyde	113-125	transformed mouse 3T3 cell double minute 2	Mus musculus	239-243
32038776-3	2008	Using polymerase chain reaction-based suppression subtractive hybridization, we recently identified 27 different formaldehyde-inducible genes including platelet-derived growth factor receptor alpha gene (PDGFRA) and mouse double minute 2 (MDM2) gene which were increased significantly in both formaldehyde-exposed human trachea cells, 680.	Formaldehyde	293-305	platelet derived growth factor receptor, alpha polypeptide	Mus musculus	152-197
32038776-3	2008	Using polymerase chain reaction-based suppression subtractive hybridization, we recently identified 27 different formaldehyde-inducible genes including platelet-derived growth factor receptor alpha gene (PDGFRA) and mouse double minute 2 (MDM2) gene which were increased significantly in both formaldehyde-exposed human trachea cells, 680.	Formaldehyde	293-305	platelet derived growth factor receptor, alpha polypeptide	Mus musculus	204-210
32038776-3	2008	Using polymerase chain reaction-based suppression subtractive hybridization, we recently identified 27 different formaldehyde-inducible genes including platelet-derived growth factor receptor alpha gene (PDGFRA) and mouse double minute 2 (MDM2) gene which were increased significantly in both formaldehyde-exposed human trachea cells, 680.	Formaldehyde	293-305	transformed mouse 3T3 cell double minute 2	Mus musculus	239-243
32038776-7	2008	Our results suggest that the elevated levels of PDGFRA and MDM2 may be associated with the formaldehyde-induced pathophysiology that is closely related with SBS, and that they deserve evaluation as potential biomarkers for formaldehyde intoxication.	Formaldehyde	91-103	platelet derived growth factor receptor alpha	Rattus norvegicus	48-54
32038776-7	2008	Our results suggest that the elevated levels of PDGFRA and MDM2 may be associated with the formaldehyde-induced pathophysiology that is closely related with SBS, and that they deserve evaluation as potential biomarkers for formaldehyde intoxication.	Formaldehyde	91-103	MDM2 proto-oncogene	Rattus norvegicus	59-63
32038776-7	2008	Our results suggest that the elevated levels of PDGFRA and MDM2 may be associated with the formaldehyde-induced pathophysiology that is closely related with SBS, and that they deserve evaluation as potential biomarkers for formaldehyde intoxication.	Formaldehyde	223-235	platelet derived growth factor receptor alpha	Rattus norvegicus	48-54
18411708-2	2008	We demonstrated the differential patterns of c-fos mRNA induction by chemical somatic (formalin) and visceral (acetic acid) noxious stimuli in the rat amygdaloid nuclei, the brain regions implicated in emotion.	Formaldehyde	87-95	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	45-50
18261208-10	2008	PPARgamma expression was detected by inmunohistochemistry in formalin fixed tumors and by western blot in tumor cell lysates.	Formaldehyde	61-69	peroxisome proliferator activated receptor gamma	Mus musculus	0-9
18197882-6	2008	Formalin injection induced an ipsilateral increase in both CGRP and SP immunostaining at 1 and 2 h in the lumbar dorsal horns.	Formaldehyde	0-8	calcitonin related polypeptide alpha	Homo sapiens	59-63
18033311-5	2008	In animals, injection of a dilute solution of formalin in the skin resulted in an increase in mTNFalpha in spinal dorsal horn, without detectable sTNFalpha.	Formaldehyde	46-54	tumor necrosis factor	Mus musculus	94-103
18033311-6	2008	Local release of IL-10 achieved by gene transfer reduced the number of spontaneous flinches in the early and delayed phases of the formalin test of inflammatory pain.	Formaldehyde	131-139	interleukin 10	Homo sapiens	17-22
18275617-4	2008	METHODS: In this study, the EBV LMP1 gene variants from 42 NPC and 10 non-malignant archived formalin fixed, paraffin-embedded tissues, as well as plasma from another 35 patients with nasopharyngeal carcinoma were determined by using Polymerase Chain Reaction (PCR).	Formaldehyde	93-101	PDZ and LIM domain 7	Homo sapiens	32-36
17928188-3	2008	METHODS: We investigated the number of tumor-infiltrating FOXP3+ T(reg) in formalin-fixed HCC specimens.	Formaldehyde	75-83	forkhead box P3	Homo sapiens	58-63
19141401-4	2008	The presence of MMP-9 in cancer tissue was investigated by immunohistochemistry on formalin-fixed, wax-embedded sections of esophageal cancers.	Formaldehyde	83-91	matrix metallopeptidase 9	Homo sapiens	16-21
18333330-12	2008	In both cases, reverse transcription-polymerase chain reaction using ribonucleic acid extracted from formalin-fixed, paraffin-embedded tissues detected SYT-SSX 1 fusion gene transcripts, which are characteristic molecular findings of synovial sarcoma.	Formaldehyde	101-109	synaptotagmin 1	Homo sapiens	152-155
18333330-12	2008	In both cases, reverse transcription-polymerase chain reaction using ribonucleic acid extracted from formalin-fixed, paraffin-embedded tissues detected SYT-SSX 1 fusion gene transcripts, which are characteristic molecular findings of synovial sarcoma.	Formaldehyde	101-109	SSX family member 1	Homo sapiens	156-161
18307046-0	2008	Precise measurement of the E-cadherin repressor Snail in formalin-fixed endometrial carcinoma using protein lysate microarrays.	Formaldehyde	57-65	cadherin 1	Homo sapiens	27-37
18307046-0	2008	Precise measurement of the E-cadherin repressor Snail in formalin-fixed endometrial carcinoma using protein lysate microarrays.	Formaldehyde	57-65	snail family transcriptional repressor 1	Homo sapiens	48-53
18307046-2	2008	The aim of our study was to characterize for the first time Snail protein expression in formalin-fixed primary tumour tissues using protein lysate microarrays and correlate Snail with E-cadherin, Cytokeratin 18, and Vimentin protein abundances.	Formaldehyde	88-96	snail family transcriptional repressor 1	Homo sapiens	60-65
18045764-6	2008	We identified 27 different formaldehyde-inducible genes, including those coding for the major histocompatibility complex, class IA, calcyclin, glutathione S-transferase pi, mouse double minute 2 (MDM2), platelet-derived growth factor receptor alpha, and which are known to be associated with cell proliferation and differentiation, immunity and inflammation, and detoxification.	Formaldehyde	27-39	S100 calcium binding protein A6 (calcyclin)	Mus musculus	132-141
18045764-6	2008	We identified 27 different formaldehyde-inducible genes, including those coding for the major histocompatibility complex, class IA, calcyclin, glutathione S-transferase pi, mouse double minute 2 (MDM2), platelet-derived growth factor receptor alpha, and which are known to be associated with cell proliferation and differentiation, immunity and inflammation, and detoxification.	Formaldehyde	27-39	transformed mouse 3T3 cell double minute 2	Mus musculus	196-200
18045764-6	2008	We identified 27 different formaldehyde-inducible genes, including those coding for the major histocompatibility complex, class IA, calcyclin, glutathione S-transferase pi, mouse double minute 2 (MDM2), platelet-derived growth factor receptor alpha, and which are known to be associated with cell proliferation and differentiation, immunity and inflammation, and detoxification.	Formaldehyde	27-39	platelet derived growth factor receptor, alpha polypeptide	Mus musculus	203-248
18045764-8	2008	Further, the expression of calcyclin, glutathione S-transferase pi, PDGFRA and MDM2 were significantly induced in the tracheal epithelium of Sprague Dawley rats after formaldehyde inhalation.	Formaldehyde	167-179	S100 calcium binding protein A6	Rattus norvegicus	27-36
18045764-8	2008	Further, the expression of calcyclin, glutathione S-transferase pi, PDGFRA and MDM2 were significantly induced in the tracheal epithelium of Sprague Dawley rats after formaldehyde inhalation.	Formaldehyde	167-179	platelet derived growth factor receptor alpha	Rattus norvegicus	68-74
18045764-8	2008	Further, the expression of calcyclin, glutathione S-transferase pi, PDGFRA and MDM2 were significantly induced in the tracheal epithelium of Sprague Dawley rats after formaldehyde inhalation.	Formaldehyde	167-179	MDM2 proto-oncogene	Rattus norvegicus	79-83
18172263-0	2008	Identification of patients with (atypical) MUTYH-associated polyposis by KRAS2 c.34G &gt; T prescreening followed by MUTYH hotspot analysis in formalin-fixed paraffin-embedded tissue.	Formaldehyde	143-151	mutY DNA glycosylase	Homo sapiens	43-48
18592792-4	2008	METHODS: Expression of KIT was analyzed immunohistochemically (n = 12) in formalin-fixed paraffin-embedded primary uterine sarcomas.	Formaldehyde	74-82	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	23-26
18158131-4	2008	In this review, two different methods for the in situ detection of miR in paraffin embedded, formalin fixed tissues are described.	Formaldehyde	93-101	membrane associated ring-CH-type finger 8	Homo sapiens	67-70
17451461-3	2008	The aim of the present study was to evaluate HER-2 expression by immunohistochemistry (IHC) in 12 USPC formalin-fixed, paraffin-embedded (FFPE) samples.	Formaldehyde	103-111	erb-b2 receptor tyrosine kinase 2	Homo sapiens	45-50
18097950-2	2008	Recent studies on asthma and airway biology implicate changes in nitric oxide (NO) disposition in the adverse effects of formaldehyde, principally because enzymatic reduction of the endogenous bronchodilator S-nitrosoglutathione (GSNO) is dependent upon GSNO reductase (formally designated as alcohol dehydrogenase-3, ADH3), which also serves as the primary enzyme for cellular detoxification of formaldehyde.	Formaldehyde	121-133	alcohol dehydrogenase 1C (class I), gamma polypeptide	Homo sapiens	318-322
18097950-3	2008	Considering recent evidence that regulation of bronchodilators like GSNO might play a more important role in asthma than inflammation per se, formaldehyde also needs to be considered as influencing ADH3-mediated GSNO catabolism.	Formaldehyde	142-154	alcohol dehydrogenase 1C (class I), gamma polypeptide	Homo sapiens	198-202
17981405-6	2008	Following qRT-PCR for glyceraldehyde-3-phosphate dehydrogenase (GAPDH), total RNA from HOPE-fixed tissues showed higher levels of target messenger ribonucleic acid (mRNA) (4.05 x 10(-2)pg/100 ng total RNA using the commercial kit and 6.45 x 10(-2)pg/100 ng total RNA using Trizol) in comparison to formalin-fixed tissues (5.69 x 10(-4)pg/100 ng total RNA).	Formaldehyde	298-306	LOC786101	Bos taurus	64-69
18190238-0	2008	PCR analysis of immunoglobulin heavy chain and TCR gene rearrangements in diagnosis of lymphoproliferative disorders on formalin-fixed, paraffin-embedded tissues.	Formaldehyde	120-128	immunoglobulin heavy constant delta	Homo sapiens	16-42
18580071-0	2008	A novel CD11c monoclonal antibody effective in formalin-fixed tissue for the diagnosis of hairy cell leukemia.	Formaldehyde	47-55	integrin subunit alpha X	Homo sapiens	8-13
18580071-3	2008	In this study, we assessed the utility of a newly developed antibody against a formalin-resistant CD11c epitope (5D11) for the diagnosis and monitoring of HCL in formalin-fixed tissue.	Formaldehyde	79-87	integrin subunit alpha X	Homo sapiens	98-103
18580071-3	2008	In this study, we assessed the utility of a newly developed antibody against a formalin-resistant CD11c epitope (5D11) for the diagnosis and monitoring of HCL in formalin-fixed tissue.	Formaldehyde	162-170	integrin subunit alpha X	Homo sapiens	98-103
18580071-4	2008	METHODS: We performed immunohistochemical staining for CD11c expression in formalin-fixed and also decalcified tissue of 196 small B-cell lymphomas, including 104 cases of HCL showing extensive to minimal infiltrates.	Formaldehyde	75-83	integrin subunit alpha X	Homo sapiens	55-60
18580071-6	2008	CONCLUSION: We recommend that this CD11c antibody be added to a panel of antibodies for immunostaining of formalin-fixed material, for differentiation of HCL from other small B-cell lymphomas, and for detection of residual disease following therapy.	Formaldehyde	106-114	integrin subunit alpha X	Homo sapiens	35-40
18066593-1	2008	We aimed to detect truncated CCN3 protein variants in formalin-fixed paraffin-embedded samples of eight Wilms" tumors using anti-K19M and novel domain-specific antibodies, anti-NH2, anti-NH3, anti-NH4, and anti-NH5 raised against C-terminal (CT) domain and modules 1, 2, 3, and 4 of the CCN3 protein, respectively.	Formaldehyde	54-62	cellular communication network factor 3	Homo sapiens	29-33
19391487-2	2008	In this study we evaluated the immunohistochemical expression of AR in a series of 37 formalin-fixed, paraffin-embedded malignant salivary gland tumors using two commercially available antibodies.	Formaldehyde	86-94	androgen receptor	Homo sapiens	65-67
18390209-0	2008	[Effects of preemptively injected intrathecal lornoxicam on behavior and c-fos protein expression of rat with formalin hurting].	Formaldehyde	110-118	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	73-78
18390209-1	2008	OBJECTIVE: The objective of this study was to investigate an antinociceptive effect of preemptive intrathecal lornoxicam on behavior and expression of c-Fos protein in the spinal cord of the formalin hurting rats.	Formaldehyde	191-199	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	151-156
18390209-16	2008	CONCLUSION: Pre-intrathacal lornoxicam can successfully inhibit nociceptive behavior and c-Fos expression in spinal dorsal horn of formalin test rats.	Formaldehyde	131-139	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	89-94
18097796-0	2007	Development of an optimal antigen retrieval protocol for immunohistochemistry of retinoblastoma protein (pRB) in formalin fixed, paraffin sections based on comparison of different methods.	Formaldehyde	113-121	RB transcriptional corepressor 1	Homo sapiens	105-108
18824804-0	2008	Investigation of formaldehyde pollution of tap water and rain water using a novel visual colorimetry.	Formaldehyde	17-29	nuclear RNA export factor 1	Homo sapiens	43-46
18824804-1	2008	The pollution of tap water and rain water with formaldehyde in Toyama Pref., Japan was investigated by means of a simple, rapid and cost-effective visual colorimetry developed by us.	Formaldehyde	47-59	nuclear RNA export factor 1	Homo sapiens	17-20
18824804-2	2008	The levels of formaldehyde in three tap waters from different sources of dams on mountainside and a well-water pumped in urban area in Toyama Pref.	Formaldehyde	14-26	nuclear RNA export factor 1	Homo sapiens	36-39
18824804-10	2008	It must be concerned about the pollution of rainwater with formaldehyde, when rain water is applied for tap water and miscellaneous purpose.	Formaldehyde	59-71	nuclear RNA export factor 1	Homo sapiens	104-107
17980496-7	2007	We found that nociceptive responses are lower in ERbeta KO female than in WT female mice during the interphase and early tonic phase II of the formalin test but not during acute and late tonic phases.	Formaldehyde	143-151	estrogen receptor 2 (beta)	Mus musculus	49-55
18097796-1	2007	A novel protocol for antigen retrieval (AR) for immunohistochemistry (IHC) of retinoblastoma protein (pRB) in formalin fixed, paraffin embedded (FFPE) tissue sections was developed using 0.05% citraconic anhydride as the AR solution for heat treatment based on comparison of different methods.	Formaldehyde	110-118	RB transcriptional corepressor 1	Homo sapiens	102-105
20103886-3	2007	In this study, the expression and distribution of phosphorylated ERK (p-ERK) in normal human skin and SCC with different degrees of differentiation was examined by immunohistochemical analysis using formalin-fixed paraffin embedded sections.	Formaldehyde	199-207	mitogen-activated protein kinase 1	Homo sapiens	65-68
20103886-3	2007	In this study, the expression and distribution of phosphorylated ERK (p-ERK) in normal human skin and SCC with different degrees of differentiation was examined by immunohistochemical analysis using formalin-fixed paraffin embedded sections.	Formaldehyde	199-207	mitogen-activated protein kinase 1	Homo sapiens	72-75
18056434-0	2007	Cells deficient in the FANC/BRCA pathway are hypersensitive to plasma levels of formaldehyde.	Formaldehyde	80-92	BRCA1 DNA repair associated	Homo sapiens	28-32
18056434-6	2007	Here, we show that the hypersensitivity to formaldehyde is detected in DT40 mutants deficient in the BRCA/FANC pathway, homologous recombination, or translesion DNA synthesis.	Formaldehyde	43-55	BRCA1 DNA repair associated	Homo sapiens	101-105
18056434-8	2007	Human cells deficient in FANCC and FANCG are also hypersensitive to plasma levels of formaldehyde.	Formaldehyde	85-97	FA complementation group C	Homo sapiens	25-30
18056434-8	2007	Human cells deficient in FANCC and FANCG are also hypersensitive to plasma levels of formaldehyde.	Formaldehyde	85-97	FA complementation group G	Homo sapiens	35-40
18055988-8	2007	Patients with type 2B VWD showed reduced binding of VWF to formalin-fixed platelets, but increased binding to autologous platelets in PRP, similar to RIPA.	Formaldehyde	59-67	von Willebrand factor	Homo sapiens	52-55
17900656-13	2007	Determination of eotaxin-3 levels by real-time polymerase chain reaction on paraffinized, formalin-fixed tissue may be a useful test in the differentiation of eosinophilic esophagitis from gastroesophageal reflux disease.	Formaldehyde	90-98	C-C motif chemokine ligand 26	Homo sapiens	17-26
17991826-3	2007	We find that recombinant murine Fto catalyzes the Fe(II)- and 2OG-dependent demethylation of 3-methylthymine in single-stranded DNA, with concomitant production of succinate, formaldehyde, and carbon dioxide.	Formaldehyde	175-187	fat mass and obesity associated	Mus musculus	32-35
17977563-3	2007	The present study was designed to test the hypothesis that peripheral TRPV1 could be involved on nociceptive behavioral responses induced by the injection of formalin into the TMJ region of rats exposed to chronic ethanol administration and ethanol withdrawal.	Formaldehyde	158-166	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	70-75
18042135-5	2007	Lepr -/- mice also devoted less activity to their injected paw during the second phase following formalin administration.	Formaldehyde	97-105	leptin receptor	Mus musculus	0-4
17966997-2	2007	The results indicate that the minimum energy pathway, similar to the reactions of its neighboring yttrium with formaldehyde, is the formation of the eta2-formaldehyde-metal complex followed by two C-H insertions which leads to metal dihydrides and carbon monoxide.	Formaldehyde	111-123	DNA polymerase iota	Homo sapiens	149-153
17966997-2	2007	The results indicate that the minimum energy pathway, similar to the reactions of its neighboring yttrium with formaldehyde, is the formation of the eta2-formaldehyde-metal complex followed by two C-H insertions which leads to metal dihydrides and carbon monoxide.	Formaldehyde	154-166	DNA polymerase iota	Homo sapiens	149-153
17928140-6	2007	Injection of 5% formalin into the MF at levels L4 and L5 induced a significant increase in the number of c-Fos-immunoreactive (-ir) nuclei in the dorsal horn in many lumbar segments.	Formaldehyde	16-24	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	105-110
18075203-5	2007	At the formalin-treated sites, genes related to neurogenic inflammation, i.e., bradykinin (BK) B2 receptor, IL-6, and membrane metallo endopeptidase (NEP) mRNA were upregulated.	Formaldehyde	7-15	interleukin 6	Mus musculus	108-112
18075203-5	2007	At the formalin-treated sites, genes related to neurogenic inflammation, i.e., bradykinin (BK) B2 receptor, IL-6, and membrane metallo endopeptidase (NEP) mRNA were upregulated.	Formaldehyde	7-15	membrane metallo endopeptidase	Mus musculus	150-153
17940995-5	2007	S100A2 expression in 14 pancreatic cancer cell lines, microdissected cells and formalin-fixed paraffin-embedded (FFPE) samples was examined by quantitative reverse transcription-polymerase chain reaction (qRT-PCR).	Formaldehyde	79-87	S100 calcium binding protein A2	Homo sapiens	0-6
17440926-4	2007	TLR9 expression was evaluated by immunohistochemistry in 55 formalin-fixed paraffin-embedded cervical tissues; nine normal cervical specimens, 10 low-grade cervical intraepithelial neoplasias (CINs), 12 high-grade CINs, and 24 invasive squamous cell carcinomas (ISCCs).	Formaldehyde	60-68	toll like receptor 9	Homo sapiens	0-4
17321048-3	2007	Intracisternal injection of 30 microg of WIN 55,212-2, a synthetic non-subtype-selective CB1/2 agonist, administered 20 min prior to formalin injection significantly reduced the number of scratches and duration of scratching induced by formalin compared with the vehicle-treated group.	Formaldehyde	236-244	cannabinoid receptor 1	Rattus norvegicus	89-94
17928140-10	2007	The number of double-labeled dorsal horn neurons (FG-positive plus c-Fos-ir) in all lumbar segments was significantly higher in the formalin group than in the saline group.	Formaldehyde	132-140	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	67-72
17948965-3	2007	We have raised a rabbit polyclonal antibody against a synthetic peptide that recognises denatured MICA on both Western blots and in formalin-fixed paraffin-embedded sections.	Formaldehyde	132-140	MHC class I polypeptide-related sequence A	Homo sapiens	98-102
17884026-7	2007	The hyperalgesic response to the formalin test was accompanied by reduced Fos expression in the paraventricular nucleus of the hypothalamus, which is part of a network (the medial pain system) that mediates motivational-affective aspects of pain.	Formaldehyde	33-41	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	74-77
17942735-2	2007	Here we show that formaldehyde activates the ion channel TRPA1 and that TRPA1-deficient mice exhibit dramatically reduced formaldehyde-induced pain responses.	Formaldehyde	18-30	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	57-62
17658213-2	2007	hENT1 expression was analyzed by immunohistochemical staining in 24 NSCLC biopsy samples of formalin-fixed, paraffin-embedded tissues.	Formaldehyde	92-100	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	0-5
17826802-2	2007	The effects of honokiol and magnolol on the formalin-induced c-Fos expression in the spinal cord dorsal horn as well as motor coordination and cognitive function were examined.	Formaldehyde	44-52	FBJ osteosarcoma oncogene	Mus musculus	61-66
17851964-10	2007	The quantity of amplifiable GAPDH mRNA in the formalin specimens was only 1% of that of the frozen specimens.	Formaldehyde	46-54	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	28-33
17711507-1	2007	A monoclonal antibody (mAb) MY.1E12 was applied to detect MUC1 with sialylated glycans in a total of 55 formalin-fixed, paraffin-embedded surgical specimens of ovarian clear cell adenocarcinomas.	Formaldehyde	104-112	mucin 1, cell surface associated	Homo sapiens	58-62
17716684-0	2007	Validation of RNA-based molecular clonotype analysis for virus-specific CD8+ T-cells in formaldehyde-fixed specimens isolated from peripheral blood.	Formaldehyde	88-100	CD8a molecule	Homo sapiens	72-75
17979543-3	2007	In spite of its importance in the diagnosis and treatment of cancer, monoclonal antibodies to FR-alpha suitable for immunohistochemical analysis of formalin-fixed and paraffin-embedded biopsy samples, or that can be used for Western blot analysis, are not available.	Formaldehyde	148-156	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	94-102
17969629-6	2007	Our results indicate that heat and formalin treatments of probiotic microorganisms are equivalent inactivation methods in terms of induction of IL-6, IL-8, and IL-10 production in Caco-2-peripheral blood mononuclear cell cocultures and do not invert immune-modulatory effects.	Formaldehyde	35-43	interleukin 6	Homo sapiens	144-148
17969629-6	2007	Our results indicate that heat and formalin treatments of probiotic microorganisms are equivalent inactivation methods in terms of induction of IL-6, IL-8, and IL-10 production in Caco-2-peripheral blood mononuclear cell cocultures and do not invert immune-modulatory effects.	Formaldehyde	35-43	interleukin 10	Homo sapiens	160-165
17826802-5	2007	Consistently, honokiol and magnolol significantly decreased formalin-induced c-Fos protein expression in superficial (I-II) laminae of the L4-L5 lumbar dorsal horn.	Formaldehyde	60-68	FBJ osteosarcoma oncogene	Mus musculus	77-82
17662046-7	2007	Interestingly, mice lacking PAFR showed reduced phosphorylation of extracellular signal-related protein kinase (ERK), an important kinase for the sensitization of primary sensory neurons, in their DRG neurons after formalin injection.	Formaldehyde	215-223	mitogen-activated protein kinase 1	Mus musculus	67-110
17553935-3	2007	Apolipoprotein E knockout (apoE-KO) mice were repeatedly immunized with formaldehyde-fixed cultured human macrophages (phorbol ester-stimulated THP-1 cells), using human serum albumin as a control protein or HepG2 cells as human control cells, once a week for four consecutive weeks.	Formaldehyde	72-84	apolipoprotein E	Mus musculus	0-16
17553935-3	2007	Apolipoprotein E knockout (apoE-KO) mice were repeatedly immunized with formaldehyde-fixed cultured human macrophages (phorbol ester-stimulated THP-1 cells), using human serum albumin as a control protein or HepG2 cells as human control cells, once a week for four consecutive weeks.	Formaldehyde	72-84	GLI family zinc finger 2	Homo sapiens	144-149
17662046-3	2007	Here we show that pafr-/- mice displayed almost normal responses to thermal and mechanical stimuli but exhibit attenuated persistent pain behaviors resulting from tissue injury by locally injecting formalin at the periphery as well as capsaicin pain and visceral inflammatory pain without any alteration in cytoarchitectural or neurochemical properties in dorsal root ganglion (DRG) neurons and a defect in motor function.	Formaldehyde	198-206	platelet-activating factor receptor	Mus musculus	18-22
17662046-7	2007	Interestingly, mice lacking PAFR showed reduced phosphorylation of extracellular signal-related protein kinase (ERK), an important kinase for the sensitization of primary sensory neurons, in their DRG neurons after formalin injection.	Formaldehyde	215-223	platelet-activating factor receptor	Mus musculus	28-32
17662046-7	2007	Interestingly, mice lacking PAFR showed reduced phosphorylation of extracellular signal-related protein kinase (ERK), an important kinase for the sensitization of primary sensory neurons, in their DRG neurons after formalin injection.	Formaldehyde	215-223	mitogen-activated protein kinase 1	Mus musculus	112-115
17662046-8	2007	Furthermore, U0126, a specific inhibitor of the ERK pathway suppressed the persistent pain by formalin.	Formaldehyde	94-102	mitogen-activated protein kinase 1	Mus musculus	48-51
18669168-1	2007	The aim of this study was to determine the localization and number of CD4- and CD8-positive T lymphocytes in bronchus-associated lymphoid tissue (BALT) of the embryos and newborns or young and adult rats exposed to formaldehyde (6 ppm), technical xylene (300 ppm), or a combination of these two agents (3 ppm + 150 ppm) for 6 weeks (8 h/day).	Formaldehyde	215-227	Cd4 molecule	Rattus norvegicus	70-73
17596537-0	2007	Evidence for in vivo scavenging by aminoguanidine of formaldehyde produced via semicarbazide-sensitive amine oxidase-mediated deamination.	Formaldehyde	53-65	amine oxidase copper containing 2	Homo sapiens	79-116
17596537-4	2007	Formaldehyde and methylglyoxal are produced via SSAO-catalyzed deamination of methylamine and aminoacetone, respectively.	Formaldehyde	0-12	amine oxidase copper containing 2	Homo sapiens	48-52
17786718-0	2007	A limited number of IgH-primers binding to framework region 1 is sufficient to detect the majority of mature small B-cell non-Hodgkin lymphomas on formalin-fixed paraffin-embedded tissue by PCR.	Formaldehyde	147-155	immunoglobulin heavy locus	Homo sapiens	20-23
17786718-1	2007	IGH gene rearrangement analysis by PCR is the widely accepted tool to determine clonality of B-cell lymphoid proliferations on formalin-fixed, paraffin-embedded tissue, but the results are often unsatisfying in terms of sensitivity.	Formaldehyde	127-135	immunoglobulin heavy locus	Homo sapiens	0-3
17705020-5	2007	Additional immunohistochemical analysis showed the negative expression of transferrin receptor (TfR) on the formalin-fixed paraffin-embedded specimen.	Formaldehyde	108-116	transferrin receptor	Homo sapiens	74-94
17686976-0	2007	TRPA1 mediates formalin-induced pain.	Formaldehyde	15-23	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	0-5
17686976-3	2007	Here we show that formalin excites sensory neurons by directly activating TRPA1, a cation channel that plays an important role in inflammatory pain.	Formaldehyde	18-26	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	74-79
17686976-4	2007	Formalin induced robust calcium influx in cells expressing cloned or native TRPA1 channels, and these responses were attenuated by a previously undescribed TRPA1-selective antagonist.	Formaldehyde	0-8	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	76-81
17686976-4	2007	Formalin induced robust calcium influx in cells expressing cloned or native TRPA1 channels, and these responses were attenuated by a previously undescribed TRPA1-selective antagonist.	Formaldehyde	0-8	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	156-161
17686976-5	2007	Moreover, sensory neurons from TRPA1-deficient mice lacked formalin sensitivity.	Formaldehyde	59-67	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	31-36
17686976-6	2007	At the behavioral level, pharmacologic blockade or genetic ablation of TRPA1 produced marked attenuation of the characteristic flinching, licking, and lifting responses resulting from intraplantar injection of formalin.	Formaldehyde	210-218	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	71-76
17686976-7	2007	Our results show that TRPA1 is the principal site of formalin"s pain-producing action in vivo, and that activation of this excitatory channel underlies the physiological and behavioral responses associated with this model of pain hypersensitivity.	Formaldehyde	53-61	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	22-27
17705020-5	2007	Additional immunohistochemical analysis showed the negative expression of transferrin receptor (TfR) on the formalin-fixed paraffin-embedded specimen.	Formaldehyde	108-116	transferrin receptor	Homo sapiens	96-99
17531342-0	2007	Expansion of formalin-evoked Fos-immunoreactivity in rats with a spinal cord injury.	Formaldehyde	13-21	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	29-32
17725853-5	2007	The effect of formalin-induced pain on inhibition of morphine tolerance was reversed by the KOR antagonist nor-binaltorphimine.	Formaldehyde	14-22	opioid receptor, kappa 1	Mus musculus	92-95
17725853-6	2007	Furthermore, an antisense oligodeoxynucleotide, but not a missense oligodeoxynucleotide, against KOR completely suppressed the inhibitory effect of formalin-induced pain on morphine tolerance.	Formaldehyde	148-156	opioid receptor, kappa 1	Mus musculus	97-100
17517865-6	2007	Signaling was abrogated if the F. tularensis LVS organisms were heat or formalin killed or treated with chloramphenicol, indicating that the TLR2 agonist activity is dependent on new bacterial protein synthesis.	Formaldehyde	72-80	toll-like receptor 2	Mus musculus	141-145
17392826-4	2007	We generated a novel tumor necrosis factor receptor (TNFR)-associated factor 1 (TRAF1) antibody that recognizes a formalin-resistant epitope (Ber-TRAF1A) and investigated the expression of TRAF1, an intracellular component of TNFR signaling, in LyP and ALCL.	Formaldehyde	114-122	TNF receptor superfamily member 1A	Homo sapiens	21-51
17392826-4	2007	We generated a novel tumor necrosis factor receptor (TNFR)-associated factor 1 (TRAF1) antibody that recognizes a formalin-resistant epitope (Ber-TRAF1A) and investigated the expression of TRAF1, an intracellular component of TNFR signaling, in LyP and ALCL.	Formaldehyde	114-122	TNF receptor superfamily member 1A	Homo sapiens	53-57
17392826-4	2007	We generated a novel tumor necrosis factor receptor (TNFR)-associated factor 1 (TRAF1) antibody that recognizes a formalin-resistant epitope (Ber-TRAF1A) and investigated the expression of TRAF1, an intracellular component of TNFR signaling, in LyP and ALCL.	Formaldehyde	114-122	TNF receptor associated factor 1	Homo sapiens	80-85
17392826-4	2007	We generated a novel tumor necrosis factor receptor (TNFR)-associated factor 1 (TRAF1) antibody that recognizes a formalin-resistant epitope (Ber-TRAF1A) and investigated the expression of TRAF1, an intracellular component of TNFR signaling, in LyP and ALCL.	Formaldehyde	114-122	TNF receptor associated factor 1	Homo sapiens	146-151
17532267-5	2007	Nocifensive responses of nondiabetic and diabetic mice to formalin injection were measured 1, 3, 5, and 7 weeks after STZ, and at each time point formalin-induced spinal Fos expression was quantified.	Formaldehyde	146-154	FBJ osteosarcoma oncogene	Mus musculus	170-173
17250964-6	2007	Both 5-HT2A and 5-HT3A knock-out mice differed from wild-types by a dramatic decrease in the formalin-induced nociceptive responses for phase II (16-45 min after injection/inflammatory phase).	Formaldehyde	93-101	5-hydroxytryptamine (serotonin) receptor 2A	Mus musculus	5-17
17250964-0	2007	Mechanical, thermal and formalin-induced nociception is differentially altered in 5-HT1A-/-, 5-HT1B-/-, 5-HT2A-/-, 5-HT3A-/- and 5-HTT-/- knock-out male mice.	Formaldehyde	24-32	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	82-88
17250964-0	2007	Mechanical, thermal and formalin-induced nociception is differentially altered in 5-HT1A-/-, 5-HT1B-/-, 5-HT2A-/-, 5-HT3A-/- and 5-HTT-/- knock-out male mice.	Formaldehyde	24-32	5-hydroxytryptamine (serotonin) receptor 1B	Mus musculus	93-99
17250964-0	2007	Mechanical, thermal and formalin-induced nociception is differentially altered in 5-HT1A-/-, 5-HT1B-/-, 5-HT2A-/-, 5-HT3A-/- and 5-HTT-/- knock-out male mice.	Formaldehyde	24-32	5-hydroxytryptamine (serotonin) receptor 2A	Mus musculus	104-110
17250964-0	2007	Mechanical, thermal and formalin-induced nociception is differentially altered in 5-HT1A-/-, 5-HT1B-/-, 5-HT2A-/-, 5-HT3A-/- and 5-HTT-/- knock-out male mice.	Formaldehyde	24-32	5-hydroxytryptamine (serotonin) receptor 3A	Mus musculus	115-121
17531342-6	2007	Stereological analysis of the sham group revealed that the extent of formalin-induced Fos expression was within the lumbar dorsal horn, with numerous Fos-like immunoreactive profiles in the ipsilateral dorsal horn and some contralateral immunoreactive profiles.	Formaldehyde	69-77	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	86-89
17250964-0	2007	Mechanical, thermal and formalin-induced nociception is differentially altered in 5-HT1A-/-, 5-HT1B-/-, 5-HT2A-/-, 5-HT3A-/- and 5-HTT-/- knock-out male mice.	Formaldehyde	24-32	huntingtin	Mus musculus	131-134
17531342-6	2007	Stereological analysis of the sham group revealed that the extent of formalin-induced Fos expression was within the lumbar dorsal horn, with numerous Fos-like immunoreactive profiles in the ipsilateral dorsal horn and some contralateral immunoreactive profiles.	Formaldehyde	69-77	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	150-153
17561317-5	2007	In vitro restimulation of lymphocytes from the Protollin-eRSV immunized mice with F (MHC-I) and G (MHC-II) peptides elicited F peptide-specific CD8(+) T cells and supernatant IFNgamma, TNFalpha, IL-2 and IL-10 while the formalin-inactivated RSV (FI-RSV) vaccine elicited predominantly IL-5.	Formaldehyde	220-228	histocompatibility-2, MHC	Mus musculus	99-105
17582689-4	2007	Topical administration of 5HT2A receptor agonist, (+/-)-2,5-dimethoxy-4-iodoamphetamine (DOI) onto the Vc/C2 region significantly reduced deep-nociceptive unit discharges evoked by formalin injection into the masseter muscle.	Formaldehyde	181-189	5-hydroxytryptamine receptor 2A	Rattus norvegicus	26-31
17582689-7	2007	administration of DOI affected Fos-like immunoreactivity (-LI) evoked by formalin injection into the masseter muscle.	Formaldehyde	73-81	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	31-34
17582689-9	2007	Formalin-evoked Fos-LI was significantly reduced in laminae I-II of the Vc/C2, but not vl-Vi/Vc region after i.c.v.	Formaldehyde	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	16-19
17388354-0	2007	Kinetics and rate constants of the reaction CH2OH+O2--&gt;CH2O+HO2 in the temperature range of 236-600 K. The kinetics and absolute rate constants of the gas-phase reaction of the hydroxymethyl radical (CH2OH) with molecular oxygen have been studied using laser photolysis/near-IR absorption spectroscopy.	Formaldehyde	44-48	heme oxygenase 2	Homo sapiens	63-66
17623804-4	2007	The method has been validated for the analysis of beta-catenin in archived prostate specimens fixed in formalin.	Formaldehyde	103-111	catenin beta 1	Homo sapiens	50-62
17562390-0	2007	Suppression by intrathecal BmK IT2 on rat spontaneous pain behaviors and spinal c-Fos expression induced by formalin.	Formaldehyde	108-116	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	80-85
17562390-2	2007	It was found that the formalin-induced rat spontaneous flinches and spinal c-Fos expression could be significantly suppressed by intrathecal BmK IT2 pre- or post-formalin injection in a dose-dependent manner.	Formaldehyde	22-30	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	75-80
17562390-2	2007	It was found that the formalin-induced rat spontaneous flinches and spinal c-Fos expression could be significantly suppressed by intrathecal BmK IT2 pre- or post-formalin injection in a dose-dependent manner.	Formaldehyde	162-170	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	75-80
17562390-5	2007	In addition, the suppression by intrathecal BmK IT2 on formalin-induced c-Fos expression in superficial laminae was more significant than that in deeper laminae.	Formaldehyde	55-63	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	72-77
17636064-3	2007	METHODS: tPA and von Willebrand factor (vWF), a vascular endothelial cell marker, are detected on vascular endothelium by immunoperoxidase methods with specific antibodies on formalin fixed paraffin embedded sural nerve biopsies from six diabetic and six axonal neuropathy control nerves without vasculopathy.	Formaldehyde	175-183	chromosome 20 open reading frame 181	Homo sapiens	9-12
17636064-3	2007	METHODS: tPA and von Willebrand factor (vWF), a vascular endothelial cell marker, are detected on vascular endothelium by immunoperoxidase methods with specific antibodies on formalin fixed paraffin embedded sural nerve biopsies from six diabetic and six axonal neuropathy control nerves without vasculopathy.	Formaldehyde	175-183	von Willebrand factor	Homo sapiens	17-38
17636064-3	2007	METHODS: tPA and von Willebrand factor (vWF), a vascular endothelial cell marker, are detected on vascular endothelium by immunoperoxidase methods with specific antibodies on formalin fixed paraffin embedded sural nerve biopsies from six diabetic and six axonal neuropathy control nerves without vasculopathy.	Formaldehyde	175-183	von Willebrand factor	Homo sapiens	40-43
16939637-4	2007	Ca(V)3.2(-/-) mice also displayed attenuated pain responses to tonic noxious stimuli such as intraperitoneal injections of irritant agents and intradermal injections of formalin.	Formaldehyde	169-177	caveolin 3	Mus musculus	0-6
17341475-1	2007	This study identifies the actin-binding protein, coronin-1a, as a novel and effective immunohistochemical marker for microglia in both cell cultures and in formaldehyde-fixed, paraffin-embedded tissue.	Formaldehyde	156-168	coronin 1A	Homo sapiens	49-59
17581402-1	2007	The immunohistochemical expression of p16 in formalin-fixed and paraffin-embedded histological sections was evaluated in a retrospective study comprising a low-grade group of 100 cases of cervical intraepithelial neoplasia (CIN) 1, a high-grade group of 50 cases of CIN 2 to 3, and a benign group of 50 cases of normal tissue or benign lesions in the uterine cervix.	Formaldehyde	45-53	cyclin dependent kinase inhibitor 2A	Homo sapiens	38-41
17592645-8	2007	METHODS: By direct sequencing, we analyzed the 3"-UTR of GATA4 in DNA isolated from 68 formalin-fixed explanted hearts with complex cardiac malformations encompassing ventricular, atrial, and atrioventricular septal defects.	Formaldehyde	87-95	GATA binding protein 4	Homo sapiens	57-62
17464313-4	2007	MIB1 was used to immunohistochemically visualise proliferating cells within formalin-fixed, paraffin-embedded, archival tissue sections of different vulvar premalignancies (N=48) and normal vulvar epithelium (N=16).	Formaldehyde	76-84	MIB E3 ubiquitin protein ligase 1	Homo sapiens	0-4
17544458-0	2007	Highly activated c-fos expression in specific brain regions (ependyma, circumventricular organs, choroid plexus) of histidine decarboxylase deficient mice in response to formalin-induced acute pain.	Formaldehyde	170-178	FBJ osteosarcoma oncogene	Mus musculus	17-22
17544458-0	2007	Highly activated c-fos expression in specific brain regions (ependyma, circumventricular organs, choroid plexus) of histidine decarboxylase deficient mice in response to formalin-induced acute pain.	Formaldehyde	170-178	histidine decarboxylase	Mus musculus	116-139
17544458-5	2007	The present observations provide strong evidence that an acute stressor, formalin-evoked painful stimulus elicits rapid alterations in the activity of neuroglial elements of histidine decarboxylase-deficient mice that are directly involved in the communication between the brain and the cerebrospinal fluid space.	Formaldehyde	73-81	histidine decarboxylase	Mus musculus	174-197
17098416-0	2007	Formaldehyde-sensitive sensor based on recombinant formaldehyde dehydrogenase using capacitance versus voltage measurements.	Formaldehyde	0-12	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	51-77
17098416-1	2007	A new formaldehyde-selective biosensor was constructed using NAD(+)- and glutathione-dependent recombinant formaldehyde dehydrogenase as a bio-recognition element immobilised on the surface of Si/SiO(2)/Si(3)N(4) structure.	Formaldehyde	6-18	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	107-133
17417695-2	2007	Under optimized conditions (formaldehyde 20 mg/ml, PPO 4 mg/ml and pH 7.0), the activity of immobilized PPO was 1370 U/g and its Km value for catechol was 12 mM at 25 degrees C. The highest activity of immobilized enzyme was at pH 7.4.	Formaldehyde	28-40	catechol oxidase B, chloroplastic	Solanum tuberosum	104-107
17459353-5	2007	We found that Fos-positive neurons in dorsal superficial and deep laminae of the lumbar spinal cord increased in formalin-injected animals and that AM404 significantly reduced Fos induction.	Formaldehyde	113-121	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	14-17
17552912-0	2007	Selection of vimentin-specific antibodies from the HuCAL phage display library by subtractive panning on formalin-fixed, paraffin-embedded tissue.	Formaldehyde	105-113	vimentin	Homo sapiens	13-21
17404875-7	2007	The activities of class III and IV ADH isoenzymes were measured by the photometric method with formaldehyde and with m-nitrobenzaldehyde as substrate, respectively.	Formaldehyde	95-107	aldo-keto reductase family 1 member A1	Homo sapiens	35-38
17368063-6	2007	NCCRP-1 gene expression was not induced by in vitro treatment of head kidney cells with polyinosinic polycytidylic acid (poly I:C) or lipopolysaccharide (LPS), or by in vivo injections with poly I:C or formalin killed Vibrio anguillarum.	Formaldehyde	202-210	F-box only protein 50	Ictalurus punctatus	0-7
17287466-4	2007	Increased flinching of diabetic rats was attenuated by intrathecal pretreatment with a selective COX-2 inhibitor immediately before formalin injection, confirming the involvement of COX-2 activity in diabetic hyperalgesia.	Formaldehyde	132-140	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	97-102
17287466-5	2007	Chronic treatment with insulin or ICI222155, an aldose reductase inhibitor (ARI) previously shown to prevent spinal polyol accumulation and formalin-evoked hyperalgesia in diabetic rats, prevented elevated spinal COX-2 protein and activity in diabetic rats.	Formaldehyde	140-148	aldo-keto reductase family 1 member B1	Rattus norvegicus	48-64
17505259-4	2007	The expression of COX-2 was determined immunohistochemically in formalin-fixed, paraffin-embedded specimens of 33 early Clark I/II melanomas and 58 naevi.	Formaldehyde	64-72	prostaglandin-endoperoxide synthase 2	Homo sapiens	18-23
17125961-3	2007	METHODS: Immunohistochemical detection of Cripto was performed by using mAb C13 on 120 formalin-fixed paraffin-embedded breast tumour specimens in tissue microarrays.	Formaldehyde	87-95	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	42-48
17576433-4	2007	In the present study, we analyzed expression of GalNAc4S-6ST mRNA in colorectal cancer by combining real-time RT-PCR with in situ hybridization (ISH) using archived formalin-fixed and paraffin-embedded tissue sections.	Formaldehyde	165-173	carbohydrate sulfotransferase 15	Homo sapiens	48-60
17576433-8	2007	Taken together, we show that real-time RT-PCR combined with ISH is useful to investigate quantitatively GalNAc4S-6ST mRNA expression in formalin-fixed and paraffin-embedded tissue sections, and that GalNAc4S-6ST expressed by colorectal cancer cells plays a minor role in tumor progression.	Formaldehyde	136-144	carbohydrate sulfotransferase 15	Homo sapiens	104-116
17134834-0	2007	Reduced response to the formalin test and lowered spinal NMDA glutamate receptor binding in adenosine A2A receptor knockout mice.	Formaldehyde	24-32	adenosine A2a receptor	Mus musculus	92-114
17418497-9	2007	Both SSP-sap and SP-sap reduced formalin-induced FOS expression in deep and superficial laminae of the L4 dorsal horn in parallel with the reduction in phase 2 behavior.	Formaldehyde	32-40	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	49-52
17426605-4	2007	Formalin increased spinal cord c-Fos expression and glial fibrillary acidic protein immunostaining in both wild-type and transgenic mice.	Formaldehyde	0-8	FBJ osteosarcoma oncogene	Mus musculus	31-36
17481391-7	2007	Finally, we show that TRPM8 mediates the analgesic effect of moderate cooling after administration of formalin, a painful stimulus.	Formaldehyde	102-110	transient receptor potential cation channel, subfamily M, member 8	Mus musculus	22-27
16860297-7	2007	Exposure to the photochemically generated products of BD (primarily acrolein, acetaldehyde, formaldehyde, furan and ozone) induced significant increases in cytotoxicity, IL-8, and IL-6 gene expression compared to a synthetic mixture of primary products that was created by injecting the correct concentrations of the detected products from the irradiation experiments.	Formaldehyde	92-104	interleukin 6	Homo sapiens	180-184
17493171-3	2007	The anti-CD109 antibody generated by the authors was available for formalin-fixed paraffin section, and it strongly stained myoepithelial cells and basal cells but not ductal, acinar, and secretory cells in these glands.	Formaldehyde	67-75	CD109 molecule	Homo sapiens	9-14
17445277-11	2007	Moreover, when tyrosinase and melan-A are used together, 100% of the formalin-fixed, paraffin-embedded uveal melanoma samples tested positive for one of those markers.	Formaldehyde	69-77	tyrosinase	Homo sapiens	15-25
17306826-3	2007	By contrast, using target cells silenced via a formaldehyde-based fixation-protocol, we demonstrate feasibility to detect - in a true one-way reaction - secretion of IFNgamma by alloreactive NK cells.	Formaldehyde	47-59	interferon gamma	Homo sapiens	166-174
17505702-4	2007	Formalin-fixed, paraffin-embedded archival tissue was immunostained for p53 and proliferation cell nuclear antigen.	Formaldehyde	0-8	tumor protein p53	Homo sapiens	72-75
17260000-0	2007	A simplified laboratory validated assay for MGMT promoter hypermethylation analysis of glioma specimens from formalin-fixed paraffin-embedded tissue.	Formaldehyde	109-117	O-6-methylguanine-DNA methyltransferase	Homo sapiens	44-48
17260000-5	2007	The objective of this study was to develop a reliable, clinically validated assay for detection of epigenetic silencing of the MGMT gene using formalin-fixed, paraffin-embedded brain tumor resections and methylation-specific PCR.	Formaldehyde	143-151	O-6-methylguanine-DNA methyltransferase	Homo sapiens	127-131
17561811-6	2007	Furthermore, 1400W at a dose that suppressed formalin-induced flinching behavior also blocked formalin-evoked p38 phosphorylation (activation) in the spinal cord, while nNOS inhibitor-I displayed no activity.	Formaldehyde	45-53	mitogen activated protein kinase 14	Rattus norvegicus	110-113
17561811-6	2007	Furthermore, 1400W at a dose that suppressed formalin-induced flinching behavior also blocked formalin-evoked p38 phosphorylation (activation) in the spinal cord, while nNOS inhibitor-I displayed no activity.	Formaldehyde	94-102	mitogen activated protein kinase 14	Rattus norvegicus	110-113
17535087-3	2007	Fluorescent-labeled in-situ hybridization using the formalin-fixed, paraffin-embedded material showed that the MYCN oncogene was amplified in the latter clone but not in the former clone.	Formaldehyde	52-60	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	111-115
17425390-5	2007	DESIGN: Immunohistochemical staining for MUC4 was performed on formalin-fixed, paraffin-embedded tissue samples from 343 cases of NSCLC arranged in a high-density tissue microarray.	Formaldehyde	63-71	mucin 4, cell surface associated	Homo sapiens	41-45
17478763-7	2007	Our findings confirm that the NF2 gene plays a role in the tumorigenesis of pediatric meningiomas and that chromogenic in situ hybridization is an efficient, economic, and reliable method for routinely assessing NF2 gene deletion in formalin-fixed, paraffin-embedded tissues.	Formaldehyde	233-241	NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor	Homo sapiens	212-215
17217946-5	2007	In the formalin test we observed a decreased nociceptive behavior in the first and the second phase in NF-kappaB p50(-/-) mice.	Formaldehyde	7-15	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	103-116
17083920-5	2007	RESULTS: Analysis of covariance with diagnosis, SERT genotype, age, hemisphere, postmortem interval, and time-in-formalin covariates identified a 20% increase in pulvinar neuron number and volume in SERT-ss subjects.	Formaldehyde	113-121	solute carrier family 6 member 4	Homo sapiens	199-203
17157334-7	2007	Unlike ND rats, in D rats proglumide produced dose-dependent antinociception and CCK-8 enhanced formalin-evoked flinches, as observed during the second phase of the test.	Formaldehyde	96-104	cholecystokinin	Rattus norvegicus	81-84
17195907-2	2007	METHODS: We retrospectively examined the immunohistochemical expression of RANKL in formalin-fixed, paraffin-embedded resected specimens obtained from 96 patients with HCC with (n = 16) and without (n = 80) bone metastases.	Formaldehyde	84-92	TNF superfamily member 11	Homo sapiens	75-80
17471153-9	2007	Our results suggest that BT-based ISH can be used as a molecular technique for the detection of SS18-SSX using formalin-fixed, paraffin-embedded tissues.	Formaldehyde	111-119	SS18 subunit of BAF chromatin remodeling complex	Homo sapiens	96-100
17471153-9	2007	Our results suggest that BT-based ISH can be used as a molecular technique for the detection of SS18-SSX using formalin-fixed, paraffin-embedded tissues.	Formaldehyde	111-119	SSX family member 2	Homo sapiens	101-104
17400537-2	2007	TLR2-/- resident peritoneal macrophages showed a strong impairment of TNF-alpha production in response to viable and non-viable (heat-killed, antimycotic-treated and formaldehyde-fixed) yeasts and hyphae (germ tube-bearing cells) of the high virulence C. albicans ATCC 26555 strain, as compared with macrophages from wild-type and TLR4-/- mice.	Formaldehyde	166-178	toll-like receptor 2	Mus musculus	0-4
17410641-7	2007	Also, AC5-/- mice display hypoalgesic responses to inflammatory pain induced by subcutaneous formalin injection into hindpaws, and to non-inflammatory and inflammatory visceral pain induced by injecting magnesium sulfate or acetic acid into the abdomen.	Formaldehyde	93-101	adenylate cyclase 5	Mus musculus	6-9
17471153-0	2007	Molecular detection of SS18-SSX fusion gene transcripts by cRNA in situ hybridization in synovial sarcoma using formalin-fixed, paraffin-embedded tumor tissue specimens.	Formaldehyde	112-120	SS18 subunit of BAF chromatin remodeling complex	Homo sapiens	23-27
17471153-0	2007	Molecular detection of SS18-SSX fusion gene transcripts by cRNA in situ hybridization in synovial sarcoma using formalin-fixed, paraffin-embedded tumor tissue specimens.	Formaldehyde	112-120	SSX family member 2	Homo sapiens	28-31
17257171-10	2007	The distribution and known physiological functions of the investigated ADHs and Aldh1 are compatible with a role in a defense system, protecting against alcohols, aldehydes and formaldehydes as well as being involved in retinoid metabolism.	Formaldehyde	177-190	aldehyde dehydrogenase family 1, subfamily A1	Mus musculus	80-85
17121834-6	2007	Immunoblot analysis with anti-Stoml2 antibodies showed that Stoml2 could be immunoprecipitated specifically with Mfn2 antibody either from formaldehyde-cross-linked and SDS-lysed cells or from cells lysed with digitonin.	Formaldehyde	139-151	stomatin like 2	Homo sapiens	30-36
17110616-1	2007	Immunohistochemical studies on formalin-fixed, paraffin-embedded (FFPE) tissue utilizing polyclonal antibodies form the cornerstone of many reports claiming to demonstrate erythropoietin receptor (EPOR) expression in malignant tissue.	Formaldehyde	31-39	erythropoietin receptor	Homo sapiens	172-195
17110616-1	2007	Immunohistochemical studies on formalin-fixed, paraffin-embedded (FFPE) tissue utilizing polyclonal antibodies form the cornerstone of many reports claiming to demonstrate erythropoietin receptor (EPOR) expression in malignant tissue.	Formaldehyde	31-39	erythropoietin receptor	Homo sapiens	197-201
17295648-7	2007	Reverse transcription-polymerase chain reaction (RT-PCR) assay using formalin-fixed, paraffin-embedded tissue detected FUS-CREB3L2 fusion transcripts.	Formaldehyde	69-77	FUS RNA binding protein	Homo sapiens	119-122
17295648-7	2007	Reverse transcription-polymerase chain reaction (RT-PCR) assay using formalin-fixed, paraffin-embedded tissue detected FUS-CREB3L2 fusion transcripts.	Formaldehyde	69-77	cAMP responsive element binding protein 3 like 2	Homo sapiens	123-130
17121834-6	2007	Immunoblot analysis with anti-Stoml2 antibodies showed that Stoml2 could be immunoprecipitated specifically with Mfn2 antibody either from formaldehyde-cross-linked and SDS-lysed cells or from cells lysed with digitonin.	Formaldehyde	139-151	stomatin like 2	Homo sapiens	60-66
17121834-6	2007	Immunoblot analysis with anti-Stoml2 antibodies showed that Stoml2 could be immunoprecipitated specifically with Mfn2 antibody either from formaldehyde-cross-linked and SDS-lysed cells or from cells lysed with digitonin.	Formaldehyde	139-151	mitofusin 2	Homo sapiens	113-117
17121834-9	2007	Notably, formaldehyde cross-linking revealed a "ladder" of high molecular weight protein species, indicating the presence of high molecular weight Stoml2-Mfn2 hetero-oligomers.	Formaldehyde	9-21	stomatin like 2	Homo sapiens	147-153
17121834-9	2007	Notably, formaldehyde cross-linking revealed a "ladder" of high molecular weight protein species, indicating the presence of high molecular weight Stoml2-Mfn2 hetero-oligomers.	Formaldehyde	9-21	mitofusin 2	Homo sapiens	154-158
17288388-8	2007	BCl3, AlCl3, and GaCl3 are predicted to be efficient catalysts for the silicon-directed aldol reaction as they strongly activate the formaldehyde electrophile.	Formaldehyde	133-145	BCL3 transcription coactivator	Homo sapiens	0-4
17301229-5	2007	The formalin-evoked pain licking responses are significantly reduced by the MNAC13 antibody in CD1 mice.	Formaldehyde	4-12	CD1 antigen complex	Mus musculus	95-98
17133373-9	2007	Using western blots and reverse phase protein microarrays, the receptor tyrosine kinase HER2, an important protein target for antibody based cancer treatment, was reliably measured in formalin-fixed breast cancer biopsy samples when compared with measurement by immunohistochemistry and fluorescence in situ hybridization; remarkably, immunohistochemically equivocal cases (score 2+) can be categorized according to HER2 protein abundance.	Formaldehyde	184-192	erb-b2 receptor tyrosine kinase 2	Homo sapiens	88-92
17301163-4	2007	Using the formalin test as a mouse model of persistent inflammatory pain, we show that activation of ERK in the amygdala is both necessary for and sufficient to induce long-lasting peripheral hypersensitivity to tactile stimulation.	Formaldehyde	10-18	mitogen-activated protein kinase 1	Mus musculus	101-104
17251340-0	2007	Improved detection of KIT exon 11 duplications in formalin-fixed, paraffin-embedded gastrointestinal stromal tumors.	Formaldehyde	50-58	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	22-25
17251340-8	2007	Use of the PCR assay amplifying the specific region affected by duplications and yielding 129 bp in wild-type KIT can substantially improve the detection of these mutations in formalin-fixed, paraffin-embedded GISTs.	Formaldehyde	176-184	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	110-113
17593728-2	2007	Experimental results demonstrate that complexation of Fe(II) by catechol- and thiol-containing organic ligands leads to formation of highly reactive species that reduce RDX (hexahydro-1,3,5-trinitro-1,3,5-triazine) and related N-heterocyclic nitramine explosive compounds to formaldehyde and inorganic nitrogen byproducts.	Formaldehyde	275-287	radixin	Homo sapiens	169-172
16949875-0	2007	Peripheral formalin injection induces long-lasting increases in cyclooxygenase 1 expression by microglia in the spinal cord.	Formaldehyde	11-19	prostaglandin-endoperoxide synthase 1	Rattus norvegicus	64-80
16949875-5	2007	Hind paw formalin injection increased COX-1 expression, beginning at 1 day after injection and lasting at least 2 weeks, the duration of experiments.	Formaldehyde	9-17	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	38-43
16949875-8	2007	These data indicate that both COX-1 and COX-2 are increased in the spinal cord following formalin injection, but the time course and cellular sources are different, suggesting that both COX-1 (longer time points) and COX-2 (very short time points) may be involved in spinal modulation in the formalin pain model.	Formaldehyde	89-97	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	30-35
16949875-8	2007	These data indicate that both COX-1 and COX-2 are increased in the spinal cord following formalin injection, but the time course and cellular sources are different, suggesting that both COX-1 (longer time points) and COX-2 (very short time points) may be involved in spinal modulation in the formalin pain model.	Formaldehyde	89-97	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	40-45
16949875-8	2007	These data indicate that both COX-1 and COX-2 are increased in the spinal cord following formalin injection, but the time course and cellular sources are different, suggesting that both COX-1 (longer time points) and COX-2 (very short time points) may be involved in spinal modulation in the formalin pain model.	Formaldehyde	89-97	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	186-191
16949875-8	2007	These data indicate that both COX-1 and COX-2 are increased in the spinal cord following formalin injection, but the time course and cellular sources are different, suggesting that both COX-1 (longer time points) and COX-2 (very short time points) may be involved in spinal modulation in the formalin pain model.	Formaldehyde	89-97	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	217-222
16949875-8	2007	These data indicate that both COX-1 and COX-2 are increased in the spinal cord following formalin injection, but the time course and cellular sources are different, suggesting that both COX-1 (longer time points) and COX-2 (very short time points) may be involved in spinal modulation in the formalin pain model.	Formaldehyde	292-300	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	30-35
16949875-8	2007	These data indicate that both COX-1 and COX-2 are increased in the spinal cord following formalin injection, but the time course and cellular sources are different, suggesting that both COX-1 (longer time points) and COX-2 (very short time points) may be involved in spinal modulation in the formalin pain model.	Formaldehyde	292-300	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	217-222
16949875-10	2007	PERSPECTIVE: This article reports that COX-1 expression by microglia is increased in the spinal cord after peripheral formalin injection into the rat hind paw.	Formaldehyde	118-126	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	39-44
17164758-3	2007	Preliminary microarray comparisons on DCIS and invasive carcinoma samples dissected from formalin-fixed paraffin sections showed a consistent downregulation of two previously identified FHIT-related genes, caspase 1 and BRCA1 in lesions underexpressing FHIT.	Formaldehyde	89-97	fragile histidine triad diadenosine triphosphatase	Homo sapiens	186-190
16678399-1	2007	Atmospheric formaldehyde (CH(2)O) was detected under continuous flow conditions by an on-line system comprising of a wet scrubber for a continuous transfer of the pollutant to an aqueous solution, a micro-reactor containing immobilized formaldehyde dehydrogenase (FDH) and a conductometric transducer.	Formaldehyde	12-24	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	236-262
16678399-1	2007	Atmospheric formaldehyde (CH(2)O) was detected under continuous flow conditions by an on-line system comprising of a wet scrubber for a continuous transfer of the pollutant to an aqueous solution, a micro-reactor containing immobilized formaldehyde dehydrogenase (FDH) and a conductometric transducer.	Formaldehyde	12-24	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	264-267
17164758-3	2007	Preliminary microarray comparisons on DCIS and invasive carcinoma samples dissected from formalin-fixed paraffin sections showed a consistent downregulation of two previously identified FHIT-related genes, caspase 1 and BRCA1 in lesions underexpressing FHIT.	Formaldehyde	89-97	caspase 1	Homo sapiens	206-215
17164758-3	2007	Preliminary microarray comparisons on DCIS and invasive carcinoma samples dissected from formalin-fixed paraffin sections showed a consistent downregulation of two previously identified FHIT-related genes, caspase 1 and BRCA1 in lesions underexpressing FHIT.	Formaldehyde	89-97	BRCA1 DNA repair associated	Homo sapiens	220-225
17164758-3	2007	Preliminary microarray comparisons on DCIS and invasive carcinoma samples dissected from formalin-fixed paraffin sections showed a consistent downregulation of two previously identified FHIT-related genes, caspase 1 and BRCA1 in lesions underexpressing FHIT.	Formaldehyde	89-97	fragile histidine triad diadenosine triphosphatase	Homo sapiens	253-257
17404013-5	2007	By means of immunohistochemistry we estimated the level of overexpression of bcl-2 proteins in a series of the 26 formalin fixed, paraffin-embedded samples of oral squamous cell carcinoma (OSCC).	Formaldehyde	114-122	BCL2 apoptosis regulator	Homo sapiens	77-82
21171362-6	2007	The number and staining degree of NADPH-d positive neurons began to increase at 6 h after the formalin injection in CA1, CA2 - 3 and DG of hippocampus as well as NO content, which increased most obviously at 12 h and returned to control level at 48 h. CONCLUSION: Formalin-induced inflammatory pain could induce the elevation of NOS activity in CA1, CA2 - 3 and DG of hippocampus with a certain time course, which further led to a increase of NO production in hippocampus.	Formaldehyde	94-102	carbonic anhydrase 1	Rattus norvegicus	116-119
21171362-6	2007	The number and staining degree of NADPH-d positive neurons began to increase at 6 h after the formalin injection in CA1, CA2 - 3 and DG of hippocampus as well as NO content, which increased most obviously at 12 h and returned to control level at 48 h. CONCLUSION: Formalin-induced inflammatory pain could induce the elevation of NOS activity in CA1, CA2 - 3 and DG of hippocampus with a certain time course, which further led to a increase of NO production in hippocampus.	Formaldehyde	94-102	carbonic anhydrase 2	Rattus norvegicus	121-124
17223848-1	2007	The study aimed to demonstrate the expression of nitric oxide converting enzyme, nitric oxide synthase (e-NOS), and endothelin-1 (Et-1) in formalin-fixed paraffin-embedded placental tissue, and to demonstrate a difference in staining intensity between heavy smokers and non-smokers.	Formaldehyde	139-147	endothelin 1	Homo sapiens	130-134
17181167-1	2006	A series of potent neuronal nicotinic acetylcholine receptor (nAChR) ligands based on a 3,8-diazabicyclo[4.2.0]octane core have been synthesized and evaluated for affinity and agonist efficacy at the human high affinity nicotine recognition site (halpha4beta2) and in a rat model of persistent nociceptive pain (formalin model).	Formaldehyde	312-320	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	62-67
17214847-5	2007	METHODS: mAb 57B predominantly recognizing MAGE-A4 was used to stain 119 formalin-fixed, paraffin-embedded epithelial skin tumors (actinic keratosis, bowenoid actinic keratosis, Bowen"s disease, and SCC; n = 17, 25, 61, 16, respectively) in immunocompetent patients (n = 84) and OTR (n = 35).	Formaldehyde	73-81	MAGE family member A4	Homo sapiens	43-50
17082778-2	2007	We evaluated ZAP-70 expression in 156 CLL patients by immunohistochemistry (IHC) on formalin-fixed bone marrow (BM) biopsies at diagnosis.	Formaldehyde	84-92	zeta chain of T cell receptor associated protein kinase 70	Homo sapiens	13-19
17082778-9	2007	In conclusion, immunohistological detection of ZAP-70 on formalin-fixed BM biopsies at diagnosis appears a useful methodological approach to identify patients with poor prognosis in CLL.	Formaldehyde	57-65	zeta chain of T cell receptor associated protein kinase 70	Homo sapiens	47-53
17556846-0	2007	Prolactin response to formalin is related to the acute nociceptive response and it is attenuated by combined application of different stressors.	Formaldehyde	22-30	prolactin	Rattus norvegicus	0-9
17556846-2	2007	In the present studies, the effect of the above-mentioned stressors has been investigated on formalin-induced prolactin (PRL) and corticosterone secretion.	Formaldehyde	93-101	prolactin	Rattus norvegicus	110-119
17556846-2	2007	In the present studies, the effect of the above-mentioned stressors has been investigated on formalin-induced prolactin (PRL) and corticosterone secretion.	Formaldehyde	93-101	prolactin	Rattus norvegicus	121-124
17556846-3	2007	Administrations of formalin via chronically implanted subcutaneous cannula into the hind limb without handling induce an immediate increase in both plasma PRL and corticosterone levels.	Formaldehyde	19-27	prolactin	Rattus norvegicus	155-158
17556846-5	2007	Application of formalin to animals exposed to different heterotypic stressors (like handling or insulin-induced hypoglycemia) produces an attenuated PRL response, while plasma corticosterone levels induced by the same nociceptive component remained unchanged.	Formaldehyde	15-23	prolactin	Rattus norvegicus	149-152
17556846-6	2007	Combinations of formalin injection with immobilization also show an attenuated PRL response.	Formaldehyde	16-24	prolactin	Rattus norvegicus	79-82
17556846-7	2007	The present data indicate that plasma PRL response to formalin is related to its acute nociceptive phase, and application of different stressors prior to formalin injection significantly attenuate plasma PRL levels, while it does not influence corticosterone responses.	Formaldehyde	54-62	prolactin	Rattus norvegicus	38-41
17556846-7	2007	The present data indicate that plasma PRL response to formalin is related to its acute nociceptive phase, and application of different stressors prior to formalin injection significantly attenuate plasma PRL levels, while it does not influence corticosterone responses.	Formaldehyde	154-162	prolactin	Rattus norvegicus	204-207
17049512-7	2006	These results suggest that the antinociceptive effect of methyleugenol on the second phase of formalin-induced pain may be due to the inhibition of NMDA receptor-mediated hyperalgesia via GABA(A) receptors.	Formaldehyde	94-102	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	188-195
17149777-1	2007	The catalytic oxidation of methanol to formaldehyde by pyrroloquinoline quinone (PQQ)-containing methanol dehydrogenase (MDH) was investigated at density functional B3LYP level.	Formaldehyde	39-51	malate dehydrogenase 2	Homo sapiens	97-119
17149777-1	2007	The catalytic oxidation of methanol to formaldehyde by pyrroloquinoline quinone (PQQ)-containing methanol dehydrogenase (MDH) was investigated at density functional B3LYP level.	Formaldehyde	39-51	malate dehydrogenase 2	Homo sapiens	121-124
16824598-9	2007	However, injection of formalin killed Vibrio anguillarum-induced ISG15 expression in head kidney.	Formaldehyde	22-30	ISG15 ubiquitin like modifier	Danio rerio	65-70
17401529-1	2007	Formaldehyde and methylglyoxal are generated via deamination from methylamine and aminoacetone respectively catalyzed by semicarbazide-sensitive amine oxidase (SSAO).	Formaldehyde	0-12	amine oxidase copper containing 2	Homo sapiens	121-158
17401529-1	2007	Formaldehyde and methylglyoxal are generated via deamination from methylamine and aminoacetone respectively catalyzed by semicarbazide-sensitive amine oxidase (SSAO).	Formaldehyde	0-12	amine oxidase copper containing 2	Homo sapiens	160-164
17401529-7	2007	The target on Abeta for interaction with formaldehyde was identified.	Formaldehyde	41-53	amyloid beta precursor protein	Homo sapiens	14-19
17243644-5	2007	Intrathecal and intracerebroventricular injection of orexin-A produces an analgesic effect in the formalin test and the carrageenan test and the neuropathic pain models and these effects of orexin-A are thought to be mediated by the activation of orexin-1 receptor.	Formaldehyde	98-106	hypocretin neuropeptide precursor	Rattus norvegicus	53-61
16876348-8	2006	At the tested concentrations, the methanol extract displayed a better anti-nociceptive activity than that of ASA in both the early and late phases of formalin induced nociception in mice.	Formaldehyde	150-158	anti-sarcolemmal autoantibodies	Mus musculus	109-112
17019712-2	2006	Current ER expression analysis is based on immunohistochemical (IHC) staining of ER on formalin fixed tissue sections.	Formaldehyde	87-95	estrogen receptor 1	Homo sapiens	8-10
17019712-2	2006	Current ER expression analysis is based on immunohistochemical (IHC) staining of ER on formalin fixed tissue sections.	Formaldehyde	87-95	estrogen receptor 1	Homo sapiens	81-83
16846696-7	2006	In the formalin test, EP2-/- mice, but not GlyR alpha3-/- mice, exhibited reduced nocifensive behavior.	Formaldehyde	7-15	prostaglandin E receptor 2 (subtype EP2)	Mus musculus	22-25
16516460-1	2006	A novel formaldehyde sensitive biosensor based on bacterial formaldehyde dehydrogenase (FDH) as a bio-recognition element has been developed.	Formaldehyde	8-20	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	60-86
16516460-1	2006	A novel formaldehyde sensitive biosensor based on bacterial formaldehyde dehydrogenase (FDH) as a bio-recognition element has been developed.	Formaldehyde	8-20	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	88-91
17113581-2	2006	Here we report that formalin injection in the paw produced pain behavior (flinching) and phosphorylation of spinal ERK1/2 (P-ERK1/2, indicating activation) in rats.	Formaldehyde	20-28	mitogen activated protein kinase 3	Rattus norvegicus	115-121
17113581-2	2006	Here we report that formalin injection in the paw produced pain behavior (flinching) and phosphorylation of spinal ERK1/2 (P-ERK1/2, indicating activation) in rats.	Formaldehyde	20-28	mitogen activated protein kinase 3	Rattus norvegicus	125-131
17153776-0	2006	Detection of the t(11;18) API2/MALT1 translocation associated with gastric MALT lymphoma in routine formalin-fixed, paraffin-embedded small endoscopic biopsy specimens by robust real-time RT-PCR.	Formaldehyde	100-108	baculoviral IAP repeat containing 3	Homo sapiens	26-30
17143956-2	2006	METHODS: Rabbit-anti-FHIT antibody was used to detect FHIT protein expression in 64 formalin-fixed, paraffin-embedded tissue specimens of inflammatory bowel disease (IBD) by citrate-microwave-streptavidin (SP)-HRP immunohistochemical method.	Formaldehyde	84-92	fragile histidine triad diadenosine triphosphatase	Homo sapiens	21-25
17143956-2	2006	METHODS: Rabbit-anti-FHIT antibody was used to detect FHIT protein expression in 64 formalin-fixed, paraffin-embedded tissue specimens of inflammatory bowel disease (IBD) by citrate-microwave-streptavidin (SP)-HRP immunohistochemical method.	Formaldehyde	84-92	fragile histidine triad diadenosine triphosphatase	Homo sapiens	54-58
17153776-0	2006	Detection of the t(11;18) API2/MALT1 translocation associated with gastric MALT lymphoma in routine formalin-fixed, paraffin-embedded small endoscopic biopsy specimens by robust real-time RT-PCR.	Formaldehyde	100-108	MALT1 paracaspase	Homo sapiens	31-36
17074066-3	2006	Formaldehyde and methylglyoxal are produced via deamination of, respectively, methylamine and aminoacetone catalyzed by semicarbazide-sensitive amine oxidase (SSAO, EC 1.4.3.6.	Formaldehyde	0-12	amine oxidase copper containing 2	Homo sapiens	120-157
16924126-3	2006	We used immunohistochemistry to analyze CEACAM1 expression in formalin-fixed, paraffin-embedded cervical tissues from 15 healthy women, 15 patients with low-grade squamous intraepithelial lesions (SIL), 15 patients with high-grade SIL, and 15 patients with squamous carcinomas.	Formaldehyde	62-70	CEA cell adhesion molecule 1	Homo sapiens	40-47
17131383-2	2006	METHODS: Immunofluorescent detection of PI4K230 and other PI4K isoforms was performed on formaldehyde (PFA) or ethanol fixed cells and rat brain cryosections.	Formaldehyde	89-101	phosphatidylinositol 4-kinase alpha	Homo sapiens	40-47
16966304-4	2006	The results showed that 75% of the workers exposed to phenol, 75% of the workers exposed to urea, 83.3% of workers exposed to formalin, and 92.3% of the workers exposed to mixed vapors had raised values of serum CEA (S-CEA) above normal value of the control group.	Formaldehyde	126-134	CEA cell adhesion molecule 3	Homo sapiens	212-215
16966304-6	2006	Finally, 16.6% of workers exposed to phenol, 23% of workers exposed to mixed vapors, and 33.3% of workers exposed to formalin had raised values of serum PSA (S-PSA) above the normal value of control group; there were no raised values of S-PSA in workers exposed to urea.	Formaldehyde	117-125	kallikrein related peptidase 3	Homo sapiens	153-156
16966304-6	2006	Finally, 16.6% of workers exposed to phenol, 23% of workers exposed to mixed vapors, and 33.3% of workers exposed to formalin had raised values of serum PSA (S-PSA) above the normal value of control group; there were no raised values of S-PSA in workers exposed to urea.	Formaldehyde	117-125	kallikrein related peptidase 3	Homo sapiens	160-163
16966304-6	2006	Finally, 16.6% of workers exposed to phenol, 23% of workers exposed to mixed vapors, and 33.3% of workers exposed to formalin had raised values of serum PSA (S-PSA) above the normal value of control group; there were no raised values of S-PSA in workers exposed to urea.	Formaldehyde	117-125	kallikrein related peptidase 3	Homo sapiens	160-163
17074066-3	2006	Formaldehyde and methylglyoxal are produced via deamination of, respectively, methylamine and aminoacetone catalyzed by semicarbazide-sensitive amine oxidase (SSAO, EC 1.4.3.6.	Formaldehyde	0-12	amine oxidase copper containing 2	Homo sapiens	159-163
18376796-5	2006	CD44 expression was detected using a standard immunoperoxidase method on formalin-fixed, paraffin-embedded, primary infiltrating ductal breast carcinoma tissues taken from 60 female patients who underwent mastectomy with axillary node clearance.	Formaldehyde	73-81	CD44 molecule (Indian blood group)	Homo sapiens	0-4
17030627-5	2006	However, the NMUR2 KO mice showed reduced pain sensitivity in both the hot plate and formalin tests.	Formaldehyde	85-93	neuromedin U receptor 2	Mus musculus	13-18
16979827-6	2006	In order to assess the effect of antagonizing 5-HT2A or 5-HT3 receptors on formalin-induced Fos-LI, rats were pre-treated with local (masseter muscle) administration of ketanserin or tropisetron (0.01, 0.1 mg/rat) 20 min prior to formalin injection.	Formaldehyde	75-83	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	92-95
17002712-7	2006	RESULTS: After formaldehyde inhalation, patients developed an immediate bronchial response at a significantly lower dose of mite allergen than after air exposure (the geometric mean PD(20) for Der p 1 was 34.3 ng after formaldehyde and 45.4 ng after placebo, P = 0.05).	Formaldehyde	15-27	crystallin gamma F, pseudogene	Homo sapiens	197-200
17007947-4	2006	We, therefore, investigated expression changes of KCC2 and NKCC1 in the spinal dorsal horn of the rat after the intraplantar injection of formalin as an acute nociceptive stimulus.	Formaldehyde	138-146	solute carrier family 12 member 5	Rattus norvegicus	50-54
17007947-8	2006	These results suggest that KCC2, rather than NKCC1, mainly contributes to modulating excitability of the dorsal spinal cord neurons in the initial stage of formalin-evoked hyperalgesia.	Formaldehyde	156-164	solute carrier family 12 member 5	Rattus norvegicus	27-31
17109742-4	2006	RESULTS: In the formalin-fixed and paraffin embedded normal canine liver vimentin showed staining of hepatic fibroblasts, probably including MF in portal areas and around hepatic veins; however, HSC were in general negative.	Formaldehyde	16-24	vimentin	Canis lupus familiaris	73-81
17125253-2	2006	The carbamates were designed for selective hydrolysis by one or more human carboxylesterases to release doxazolidine (Doxaz), the formaldehyde-oxazolidine of doxorubicin that cross-links DNA to trigger cell death.	Formaldehyde	130-142	carboxylesterase 1	Homo sapiens	75-92
17002712-7	2006	RESULTS: After formaldehyde inhalation, patients developed an immediate bronchial response at a significantly lower dose of mite allergen than after air exposure (the geometric mean PD(20) for Der p 1 was 34.3 ng after formaldehyde and 45.4 ng after placebo, P = 0.05).	Formaldehyde	219-231	crystallin gamma F, pseudogene	Homo sapiens	197-200
16984257-5	2006	Real-time quantitative RT-PCR assay performed on mRNA extracted from formalin-fixed paraffin-embedded CCA and normal skin (NS) samples further demonstrated the overexpression of the KGF/FGF-7 gene in all CCA samples compared with NS.	Formaldehyde	69-77	fibroblast growth factor 7	Homo sapiens	182-185
20223002-4	2006	Fluorescence in situ hybridization for HER2 was performed on "touch" slides from frozen tumour samples or formalin-fixed, paraffin-embedded tissue.	Formaldehyde	106-114	erb-b2 receptor tyrosine kinase 2	Homo sapiens	39-43
16934364-3	2006	PATIENTS AND METHODS: Eg5 expression was investigated immunohistochemically in 122 formalin-fixed tumor samples from untreated stage IIIB or IV NSCLC patients.	Formaldehyde	83-91	kinesin family member 11	Homo sapiens	22-25
16919817-15	2006	Tert-BuOOH coadminstration reversed the TEMPOL-induced analgesia in the tonic intraplantar formalin response reduction.	Formaldehyde	91-99	telomerase reverse transcriptase	Mus musculus	0-4
17167529-5	2006	The data obtained by gel filtration and nondenaturing gel electrophoresis of native PCNA molecules confirm our previous observations, obtained using formaldehyde crosslinking, in which PCNA exists in the cell as a double trimer.	Formaldehyde	149-161	proliferating cell nuclear antigen	Homo sapiens	84-88
17167529-5	2006	The data obtained by gel filtration and nondenaturing gel electrophoresis of native PCNA molecules confirm our previous observations, obtained using formaldehyde crosslinking, in which PCNA exists in the cell as a double trimer.	Formaldehyde	149-161	proliferating cell nuclear antigen	Homo sapiens	185-189
17177840-5	2006	In the current study, the expression of galectin-1 was examined in 80 formalin-fixed, paraffin-embedded cervical tissues: 20 benign cervical specimen, 20 low-grade squamous intraepithelial lesions (LGSIL), 20 high-grade squamous intraepithelial lesions (HGSIL), and 20 invasive squamous cell carcinomas (ISCC).	Formaldehyde	70-78	galectin 1	Homo sapiens	40-50
16806459-4	2006	Immunohistochemical analysis of formalin fixed tissue sections demonstrated that RANK, RANKL and TNFalpha were strongly expressed by large multinucleated cells containing polyethylene wear debris in revision tissues.	Formaldehyde	32-40	TNF superfamily member 11	Homo sapiens	87-92
16806459-4	2006	Immunohistochemical analysis of formalin fixed tissue sections demonstrated that RANK, RANKL and TNFalpha were strongly expressed by large multinucleated cells containing polyethylene wear debris in revision tissues.	Formaldehyde	32-40	tumor necrosis factor	Homo sapiens	97-105
16984257-5	2006	Real-time quantitative RT-PCR assay performed on mRNA extracted from formalin-fixed paraffin-embedded CCA and normal skin (NS) samples further demonstrated the overexpression of the KGF/FGF-7 gene in all CCA samples compared with NS.	Formaldehyde	69-77	fibroblast growth factor 7	Homo sapiens	186-191
17021140-1	2006	Clonality analysis of the immunoglobulin heavy chain (IgH) gene is helpful in identifying malignant B cell infiltrates in the bone marrow and is usually carried out on separate aspirates or on the same formalin-fixed decalcified bone marrow specimen.	Formaldehyde	202-210	immunoglobulin heavy constant delta	Homo sapiens	26-52
16826403-10	2006	CONCLUSION: The AN-7 combined with doxorubicin overcame drug resistance; at least in part by the intracellularly releasable formaldehyde that augmented formation of doxorubicin-DNA adducts and butyric acid that induced histone and p53 acetylation.	Formaldehyde	124-136	tumor protein p53	Homo sapiens	231-234
16949920-5	2006	In a combined analysis of immunohistochemistry and fluorescence in situ hybridization on 552 formalin-fixed and paraffin-embedded gastric cancer tissues, 38 cases were found to have HER2 amplification.	Formaldehyde	93-101	erb-b2 receptor tyrosine kinase 2	Homo sapiens	182-186
17183836-1	2006	The present study provides an analysis of immunohistochemical expression and localization of epidermal growth factor receptor (EGFR) in formalin fixed paraffin embedded specimens of prostate.	Formaldehyde	136-144	epidermal growth factor receptor	Homo sapiens	93-125
17183836-1	2006	The present study provides an analysis of immunohistochemical expression and localization of epidermal growth factor receptor (EGFR) in formalin fixed paraffin embedded specimens of prostate.	Formaldehyde	136-144	epidermal growth factor receptor	Homo sapiens	127-131
17021140-1	2006	Clonality analysis of the immunoglobulin heavy chain (IgH) gene is helpful in identifying malignant B cell infiltrates in the bone marrow and is usually carried out on separate aspirates or on the same formalin-fixed decalcified bone marrow specimen.	Formaldehyde	202-210	immunoglobulin heavy constant delta	Homo sapiens	54-57
17013093-6	2006	Expression of CDK-2 was determined immunohistochemically in formalin-fixed paraffin-embedded specimens comprising 76 lesions including 41 primary cutaneous melanomas, 15 lymph node melanoma metastases (in eight cases correlated with primary tumours), three melanoma recurrences (two cases correlated with both primary and metastatic melanomas) and 17 nevi.	Formaldehyde	60-68	cyclin dependent kinase 2	Homo sapiens	14-19
16517973-0	2006	Characterization of anti-TIMP-1 monoclonal antibodies for immunohistochemical localization in formalin-fixed, paraffin-embedded tissue.	Formaldehyde	94-102	TIMP metallopeptidase inhibitor 1	Homo sapiens	25-31
16517973-1	2006	The aim of this study was to evaluate seven anti-TIMP-1 (tissue inhibitor of metalloproteinase-1) monoclonal antibodies by immunohistochemical (IHC) staining of formalin-fixed, paraffin-embedded (FFPE) tissue.	Formaldehyde	161-169	TIMP metallopeptidase inhibitor 1	Homo sapiens	49-55
16970983-3	2006	In the formalin test, among all substances tested only alpha-MSH (1 micromol/kg) statistically significantly inhibited the formalin-induced first phase pain response, however, all tested peptides (except gamma1-MSH) at the dose of 1 micromol/kg produced a pronounced inhibitory effect on nociceptive behavior in the second phase and this activity was comparable with that of indomethacin (reference drug, 5 mg/kg intraperitoneally); beta-MSH was also active at a dose 0.1 micromol/kg.	Formaldehyde	123-131	pro-opiomelanocortin-alpha	Mus musculus	433-441
17080715-0	2006	Quantitative mRNA expression analysis of neurotrophin-receptor TrkC and oncogene c-MYC from formalin-fixed, paraffin-embedded primitive neuroectodermal tumor samples.	Formaldehyde	92-100	brain derived neurotrophic factor	Homo sapiens	41-53
16970983-6	2006	These data indicate that peripherally administered melanocortin receptor agonists alpha-MSH, beta-MSH and gamma2-MSH, as well as MC3/4 receptor antagonist HS014 induced antinociception on pain/inflammatory events caused by formalin suggesting a predominant anti-inflammatory role of these peptides.	Formaldehyde	223-231	pro-opiomelanocortin-alpha	Mus musculus	82-91
16970983-6	2006	These data indicate that peripherally administered melanocortin receptor agonists alpha-MSH, beta-MSH and gamma2-MSH, as well as MC3/4 receptor antagonist HS014 induced antinociception on pain/inflammatory events caused by formalin suggesting a predominant anti-inflammatory role of these peptides.	Formaldehyde	223-231	pro-opiomelanocortin-alpha	Mus musculus	93-101
16863646-2	2006	In the immunoblot assay, subcutaneous (s.c.) injection with formalin increased the pERK and pCaMK-IIalpha level in the spinal cord, and an immunohistochemical study showed that the increase of pERK and pCaMK-IIalpha immunoreactivity mainly occurred in the laminae I and II areas of the spinal dorsal horn.	Formaldehyde	60-68	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	83-87
17062944-0	2006	[Effect of intrathecal katemine on the expression of nNOS in spinal dorsal horn in rats with formalin pain].	Formaldehyde	93-101	nitric oxide synthase 1	Rattus norvegicus	53-57
17062944-1	2006	OBJECTIVE: To investigate the expression of neuronal nitric oxide synthase (nNOS) in spinal dorsal horn and the effect of intrathecal katemine on the expression of nNOS in the rats with formalin-induced pain.	Formaldehyde	186-194	nitric oxide synthase 1	Rattus norvegicus	164-168
17062944-8	2006	RESULTS: Compared with Group NS, PIS of Group K1 and K2 was decreased obviously (P&lt;0.01) in the second phase of formalin pain.	Formaldehyde	115-123	keratin 1	Rattus norvegicus	46-55
17062944-11	2006	Intrathecal katemine significantly inhibited the increase of nNOS expression in the spinal dorsal horn of formalin-induced pain, suggesting nNOS plays an important role in nociceptive transmission and modulation of the spinal cord.	Formaldehyde	106-114	nitric oxide synthase 1	Rattus norvegicus	61-65
17062944-11	2006	Intrathecal katemine significantly inhibited the increase of nNOS expression in the spinal dorsal horn of formalin-induced pain, suggesting nNOS plays an important role in nociceptive transmission and modulation of the spinal cord.	Formaldehyde	106-114	nitric oxide synthase 1	Rattus norvegicus	140-144
16970304-6	2006	The method has the required sensitivity for analyses of formaldehyde in urban air on relatively small volume grab samples of whole air (10-70L STP), potentially providing high temporal resolution.	Formaldehyde	56-68	sulfotransferase family 1A member 1	Homo sapiens	143-146
16863646-2	2006	In the immunoblot assay, subcutaneous (s.c.) injection with formalin increased the pERK and pCaMK-IIalpha level in the spinal cord, and an immunohistochemical study showed that the increase of pERK and pCaMK-IIalpha immunoreactivity mainly occurred in the laminae I and II areas of the spinal dorsal horn.	Formaldehyde	60-68	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	193-197
16765633-11	2006	DCM formed significantly higher levels of formaldehyde in the cytosol of the V79 mGSTT1 cells than in the cytosol of the V79 MZ cells.	Formaldehyde	42-54	glutathione S-transferase, theta 1	Mus musculus	81-87
16863646-10	2006	Our results suggest that pERK and pCaMK-II located at both the spinal cord and supraspinal levels are an important regulator during the nociceptive processes induced by formalin administered s.c. respectively.	Formaldehyde	169-177	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	25-29
16765633-13	2006	These results indicate that V79 mGSTT1 can metabolize DCM to a genotoxic and cytotoxic metabolite, which is likely formaldehyde.	Formaldehyde	115-127	glutathione S-transferase, theta 1	Mus musculus	32-38
16931951-0	2006	Molecular detection of FUS-CREB3L2 fusion transcripts in low-grade fibromyxoid sarcoma using formalin-fixed, paraffin-embedded tissue specimens.	Formaldehyde	93-101	FUS RNA binding protein	Homo sapiens	23-26
16931951-0	2006	Molecular detection of FUS-CREB3L2 fusion transcripts in low-grade fibromyxoid sarcoma using formalin-fixed, paraffin-embedded tissue specimens.	Formaldehyde	93-101	cAMP responsive element binding protein 3 like 2	Homo sapiens	27-34
16931951-4	2006	In the present study, we conducted a reverse transcription-polymerase chain reaction assay to detect the FUS-CREB3L2 fusion transcripts using formalin-fixed, paraffin-embedded tumor tissue specimens from 16 LGFMSs including 3 cases with giant collagen rosettes.	Formaldehyde	142-150	FUS RNA binding protein	Homo sapiens	105-108
16931951-4	2006	In the present study, we conducted a reverse transcription-polymerase chain reaction assay to detect the FUS-CREB3L2 fusion transcripts using formalin-fixed, paraffin-embedded tumor tissue specimens from 16 LGFMSs including 3 cases with giant collagen rosettes.	Formaldehyde	142-150	cAMP responsive element binding protein 3 like 2	Homo sapiens	109-116
16938520-3	2006	The combined pattern analysis and detection of 70-kd zeta-associated protein (ZAP-70) expression in formalin-fixed, paraffin-embedded bone marrow trephines has not been investigated so far.	Formaldehyde	100-108	zeta chain of T cell receptor associated protein kinase 70	Homo sapiens	78-84
16948517-6	2006	A CD10 monoclonal antibody was applied to formalin-fixed, paraffin-embedded tissue.	Formaldehyde	42-50	membrane metalloendopeptidase	Homo sapiens	2-6
16999119-5	2006	In the reaction of NO3 radicals with PVE propylformate 52.7 +/- 5.9% and formaldehyde 55.0 +/- 6.3% were again observed as major products.	Formaldehyde	73-85	NBL1, DAN family BMP antagonist	Homo sapiens	19-22
17718267-6	2006	METHOD: The overexpression and amplification of c-Myc in malignant lymphoma were studied by means of immunohistochemistry and chromogenic in situ hybridization (CISH), respectively, in formalin-fixed, paraffin-embedded specimens.	Formaldehyde	185-193	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	48-53
16861172-1	2006	The study was designed to determine whether the protein kinase C (PKC) is involved in nociceptive c-Fos expression and the concomitant signaling processes of endogenous opioid-like substances (OLS) that modulate c-Fos expression in the spinal dorsal horn following formalin injection into the unilateral hindpaw in rats by using immunocytochemical techniques.	Formaldehyde	265-273	protein kinase C, gamma	Rattus norvegicus	48-64
16861172-1	2006	The study was designed to determine whether the protein kinase C (PKC) is involved in nociceptive c-Fos expression and the concomitant signaling processes of endogenous opioid-like substances (OLS) that modulate c-Fos expression in the spinal dorsal horn following formalin injection into the unilateral hindpaw in rats by using immunocytochemical techniques.	Formaldehyde	265-273	protein kinase C, gamma	Rattus norvegicus	66-69
16651388-7	2006	Development of this novel NK1 receptor antibody allows the efficient localization of NK1 receptor protein in human formalin-fixed, paraffin-embedded tissues.	Formaldehyde	115-123	tachykinin receptor 1	Homo sapiens	26-29
16651388-7	2006	Development of this novel NK1 receptor antibody allows the efficient localization of NK1 receptor protein in human formalin-fixed, paraffin-embedded tissues.	Formaldehyde	115-123	tachykinin receptor 1	Homo sapiens	26-38
16791853-7	2006	Intrathecally injected STG antisense oligodeoxyribonucleotide (ODN) specifically decreased STG expression in the lumbar spinal cord and dose dependently inhibited formalin-induced inflammatory pain in the second phase.	Formaldehyde	163-171	calcium voltage-gated channel auxiliary subunit gamma 2	Homo sapiens	23-26
16841374-5	2006	The approach has been validated by comparison of results with standard analyses for HER-2 amplification status in formalin-fixed, paraffin-embedded breast cancers and is applicable to the analysis of other clinically relevant genomic aberrations as well as of use in research investigations.	Formaldehyde	114-122	erb-b2 receptor tyrosine kinase 2	Homo sapiens	84-89
16791853-8	2006	More important was our finding for the first time that this specific STG antisense ODN diminished AMPA (0.1 mug)-enhanced formalin pain and lost its effect if pretreated with AMPA receptor antagonist CNQX.	Formaldehyde	122-130	calcium voltage-gated channel auxiliary subunit gamma 2	Homo sapiens	69-72
17048493-1	2006	In the study, methoxy polyethyleneglycol (MPEG) linked chitosan (PLC) with a different degrees of substitution were prepared using a novel yet simple method in the presence of formaldehyde in a solvent of formic acid and dimethylsulfoxide (DMSO).	Formaldehyde	176-188	heparan sulfate proteoglycan 2	Homo sapiens	65-68
17037611-4	2006	We describe application of a DNA extraction procedure for formalin-fixed, paraffin-embedded tissues (PET) for the purpose of PCR amplification and nucleotide sequencing of relevant codons (136-171) of the sheep PrP gene.	Formaldehyde	58-66	major prion protein	Ovis aries	211-214
16697109-9	2006	Collectively, these results demonstrate that endogenous N/OFQ-NOP receptor signalling is activated during the mouse formalin test producing spinal antinociceptive and supraspinal pronociceptive effects.	Formaldehyde	116-124	prepronociceptin	Mus musculus	56-61
16697109-9	2006	Collectively, these results demonstrate that endogenous N/OFQ-NOP receptor signalling is activated during the mouse formalin test producing spinal antinociceptive and supraspinal pronociceptive effects.	Formaldehyde	116-124	crystallin, gamma B	Mus musculus	62-65
16782271-0	2006	Increased formalin-induced pain and expression of fos neurons in the lumbar spinal cord of prenatally stressed infant rats.	Formaldehyde	10-18	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	50-53
16854390-6	2006	c-Fos expression, determined in the arcuate nucleus of the hypothalamus in the same animals 1 week after the last formalin test, was higher in GDX than INT animals; moreover, while in INT rats, c-Fos was higher in the formalin-injected animals (SF and FF) than in HC, in GDX, it did not differ among groups.	Formaldehyde	114-122	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-5
16854390-6	2006	c-Fos expression, determined in the arcuate nucleus of the hypothalamus in the same animals 1 week after the last formalin test, was higher in GDX than INT animals; moreover, while in INT rats, c-Fos was higher in the formalin-injected animals (SF and FF) than in HC, in GDX, it did not differ among groups.	Formaldehyde	218-226	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-5
16883392-2	2006	Formyl radicals (HCO) were produced from the reaction of atomic chlorine, generated by photolysis of Cl2 at 335 nm, with formaldehyde.	Formaldehyde	121-133	endogenous retrovirus group W member 5	Homo sapiens	101-104
16782271-6	2006	Prenatally stressed infants showed increased nociceptive responses in the second, tonic phase and a large increase in the number of formalin-induced Fos-LI neurons in the lumbar dorsal horn, a result consistent with the behavioral data.	Formaldehyde	132-140	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	149-152
16827667-4	2006	The presence of CD34 mRNA and glycoprotein was assessed on formalin-fixed, paraffin-embedded canine skin samples by in situ hybridization technique and by standard immunohistochemistry, respectively.	Formaldehyde	59-67	CD34 molecule	Canis lupus familiaris	16-20
17111600-1	2006	A method of compound-specific stable carbon isotopic analysis for the research about the sources of atmospheric formaldehyde was preliminary studied using gas chromatography/combustion/isotope ratio mass spectrometry (GC/C/IRMS) via 2, 4-dinitrophenylhydrazine (DNPH) derivatization.	Formaldehyde	112-124	guanylate cyclase 2C	Homo sapiens	218-222
16944837-4	2006	However, persistent TMJ inflammation significantly increased Fos-LI neurons in the nucleus raphe magnus (NRM) induced by subsequent formalin injection of the masseter muscle and hindpaw (70.2% increase and 53.8% increase, respectively, over the control TMJ-saline-injected rats; P &lt; 0.05).	Formaldehyde	132-140	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	61-64
16765320-4	2006	Surprisingly, knock-down of GLAST in the spinal cord using antisense-oligonucleotides decreased glutamate concentrations in cerebrospinal fluid (CSF) and reduced the nociceptive behaviour in the rat formalin assay.	Formaldehyde	199-207	solute carrier family 1 member 3	Rattus norvegicus	28-33
16942137-0	2006	Correlated v(H(2) ) and j(CO) product states from formaldehyde photodissociation: dynamics of molecular elimination.	Formaldehyde	50-62	relaxin 2	Homo sapiens	11-17
16942138-5	2006	After excitation of formaldehyde above the threshold for the radical channel (H(2)CO--&gt;H+HCO) we also find formation of rotationally cold CO (j(CO)=5-28) correlated to highly vibrationally excited H(2) (v=6-8).	Formaldehyde	20-32	CD101 molecule	Homo sapiens	206-211
16827883-3	2006	Mannan-binding lectin genotypes were identified with polymerase chain reaction on stored samples of stem cells or formalin-fixed paraffin-embedded bone marrow biopsies.	Formaldehyde	114-122	mannose binding lectin 2	Homo sapiens	0-21
16682960-0	2006	Intrathecal treatment with sigma1 receptor antagonists reduces formalin-induced phosphorylation of NMDA receptor subunit 1 and the second phase of formalin test in mice.	Formaldehyde	63-71	sigma non-opioid intracellular receptor 1	Mus musculus	27-42
16557382-5	2006	Syndecan-1 expression was assessed from formalin-fixed and paraffin-embedded tumour samples using immunohistochemistry.	Formaldehyde	40-48	syndecan 1	Homo sapiens	0-10
16729981-1	2006	Mice that lack A Disintegrin And Metalloprotease 11 (ADAM11) protein showed normal responses to stimuli in the von Frey test and the hot plate test, but showed reduced responses in the formalin paw test and acetic acid writhing test.	Formaldehyde	185-193	a disintegrin and metallopeptidase domain 11	Mus musculus	15-51
16729981-1	2006	Mice that lack A Disintegrin And Metalloprotease 11 (ADAM11) protein showed normal responses to stimuli in the von Frey test and the hot plate test, but showed reduced responses in the formalin paw test and acetic acid writhing test.	Formaldehyde	185-193	a disintegrin and metallopeptidase domain 11	Mus musculus	53-59
16819153-3	2006	In the present study, we employed a sensitive, reliable immunohistochemical detection system for N-cadherin on formalin-fixed, paraffin-embedded tissue sections, and succeeded in demonstrating N- and E-cadherin protein expressions and their distribution in normal human tissues.	Formaldehyde	111-119	cadherin 2	Homo sapiens	97-107
16819153-8	2006	The method presented here should prove useful for the further investigation of the N-cadherin expression and function in several disease conditions on formalin-fixed, paraffin-embedded archival tissues.	Formaldehyde	151-159	cadherin 2	Homo sapiens	83-93
16914952-1	2006	In the present study, involvement of D1 and D2 dopamine receptors in the antinociception and tolerance induced by water swim stress in the formalin test has been investigated.	Formaldehyde	139-147	dopamine receptor D2	Homo sapiens	37-65
16914952-3	2006	Intraperitoneal administration of the D2 dopamine receptor antagonist, sulpiride (25 and 50 mg/kg) reduced swim stress-induced antinociception in the second phase of the formalin test.	Formaldehyde	170-178	dopamine receptor D2	Homo sapiens	38-58
16682960-0	2006	Intrathecal treatment with sigma1 receptor antagonists reduces formalin-induced phosphorylation of NMDA receptor subunit 1 and the second phase of formalin test in mice.	Formaldehyde	147-155	sigma non-opioid intracellular receptor 1	Mus musculus	27-42
16682960-2	2006	The aim of present study was to determine the role of the spinal sigma(1) receptor in formalin-induced pain behavior, spinal cord Fos expression and phosphorylation of N-methyl-D-aspartate receptor subunit 1 (pNR1).	Formaldehyde	86-94	sigma non-opioid intracellular receptor 1	Mus musculus	65-82
16461563-5	2006	METHODS: The pattern of PPH3 staining in formalin-fixed paraffin wax-embedded tissues, including normal tissues and a series of 39 breast adenocarcinomas, was examined.	Formaldehyde	41-49	protein phosphatase 4 catalytic subunit	Homo sapiens	24-28
16723714-3	2006	Here, we developed a novel allele-specific real-time PCR assay to detect the Cav-1 P132L mutation in mammary tumor cells isolated by laser capture microdissection from formalin-fixed paraffin-embedded breast cancer samples.	Formaldehyde	168-176	caveolin 1	Homo sapiens	77-82
16785783-5	2006	Immunohistochemical evaluation of TRAIL expression was performed on formalin-fixed paraffin-embedded sections from 29 GE junction/esophageal biopsies, 20 gastric biopsies, 6 esophagectomies, 2 small bowel resection specimens, and 5 colon biopsies.	Formaldehyde	68-76	TNF superfamily member 10	Homo sapiens	34-39
16785796-3	2006	The authors developed the first rabbit anti-PgR mAb (clone SP2) used in IHC on formalin-fixed, paraffin-embedded tissue sections from breast carcinomas.	Formaldehyde	79-87	progesterone receptor	Homo sapiens	44-47
16785796-3	2006	The authors developed the first rabbit anti-PgR mAb (clone SP2) used in IHC on formalin-fixed, paraffin-embedded tissue sections from breast carcinomas.	Formaldehyde	79-87	Sp2 transcription factor	Homo sapiens	59-62
16682960-6	2006	injection of BD-1047 also reduced formalin-evoked Fos expression and pNR1 at the protein kinase C-dependent site, serine-896 (Ser896) and the protein kinase A-dependent site, serine-897 (Ser897) in spinal dorsal horn.i.t.	Formaldehyde	34-42	FBJ osteosarcoma oncogene	Mus musculus	50-53
16682960-12	2006	BMY-14802 significantly reduced formalin-evoked Fos expression and pNR1 (Ser896 and Ser897) expression in spinal dorsal horn.	Formaldehyde	32-40	FBJ osteosarcoma oncogene	Mus musculus	48-51
16622452-3	2006	TM immunostaining was performed on formalin-fixed, paraffin-embedded tissue sections, from primary lesions of 200 patients with colorectal carcinoma.	Formaldehyde	35-43	thrombomodulin	Homo sapiens	0-2
16446041-11	2006	By examining expression of Fos protein in response to intraplantar injection of formaldehyde we provide evidence that many of the preprotachykinin B cells in lamina I and the outer part of lamina II respond to noxious stimulation.	Formaldehyde	80-92	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	27-30
16718270-4	2006	The expression of lysosome-associated membrane protein-1 was for the first time determined immunohistochemically in formalin-fixed paraffin-embedded specimens comprising 42 primary cutaneous melanomas, 15 lymph node melanoma metastases (11 correlated with primary tumours), three melanoma recurrences (correlated with both primary and metastatic melanomas), 27 nevi and four epithelial tumours (two seborrhoeic keratoses and two basal cell carcinomas).	Formaldehyde	116-124	lysosomal associated membrane protein 1	Homo sapiens	18-56
16704222-0	2006	Identification of formaldehyde-induced modifications in proteins: reactions with insulin.	Formaldehyde	18-30	insulin	Homo sapiens	81-88
16704222-4	2006	Therefore, insulin was treated with excess formaldehyde (CH2O) or deuterated formaldehyde (CD2O).	Formaldehyde	43-55	insulin	Homo sapiens	11-18
16704222-4	2006	Therefore, insulin was treated with excess formaldehyde (CH2O) or deuterated formaldehyde (CD2O).	Formaldehyde	57-61	insulin	Homo sapiens	11-18
16704222-5	2006	In a separate experiment, insulin was modified by formaldehyde (CH2O vs CD2O) and glycine.	Formaldehyde	50-62	insulin	Homo sapiens	26-33
16704222-5	2006	In a separate experiment, insulin was modified by formaldehyde (CH2O vs CD2O) and glycine.	Formaldehyde	64-68	insulin	Homo sapiens	26-33
16704222-8	2006	Seven intramolecular cross-links were identified in formaldehyde-treated insulin.	Formaldehyde	52-64	insulin	Homo sapiens	73-80
16704222-9	2006	Furthermore, eight out of the sixteen potentially reactive sites of the insulin molecule were modified by incubation with formaldehyde and glycine.	Formaldehyde	122-134	insulin	Homo sapiens	72-79
16541017-4	2006	CXCR1 was localized in 81 formalin-fixed, paraffin-embedded renal specimens by immunohistochemistry using a monoclonal antibody against human CXCR1.	Formaldehyde	26-34	C-X-C motif chemokine receptor 1	Homo sapiens	0-5
16682285-10	2006	This work helps to characterize the spectrum of mutations in the Brazilian population, and to confirm that formaldehyde-fixed paraffin tissue can provide valuable information on the RB1 status in retinoblastoma patients.	Formaldehyde	107-119	RB transcriptional corepressor 1	Homo sapiens	182-185
16700663-5	2006	An immunohistochemical method was used to investigate the expression of COX-2 and p53 proteins on formalin-fixed, paraffin-embedded tissue specimens of squamous cell carcinomas (SCC), basal cell carcinomas (BCC), Bowen"s disease (BD), actinic keratosis (AK) and porokeratosis.	Formaldehyde	98-106	prostaglandin-endoperoxide synthase 2	Homo sapiens	72-77
16700663-5	2006	An immunohistochemical method was used to investigate the expression of COX-2 and p53 proteins on formalin-fixed, paraffin-embedded tissue specimens of squamous cell carcinomas (SCC), basal cell carcinomas (BCC), Bowen"s disease (BD), actinic keratosis (AK) and porokeratosis.	Formaldehyde	98-106	tumor protein p53	Homo sapiens	82-85
16677304-6	2006	DHA toxicity did, however, not solely appear related to formaldehyde accumulation, because SFA1 overexpression only enhanced formaldehyde but not DHA tolerance.	Formaldehyde	125-137	bifunctional alcohol dehydrogenase/S-(hydroxymethyl)glutathione dehydrogenase	Saccharomyces cerevisiae S288C	91-95
16648762-4	2006	STUDY DESIGN: The expression of beta-catenin (BD Transduction Laboratories) was analyzed by immunohistochemistry in formalin-fixed, paraffin embedded specimens by the avidin-biotin-peroxidase complex method in 16 pleomorphic adenomas (12 from minor salivary glands), 3 carcinomas in pleomorphic adenomas (all from palate) and 10 normal salivary glands as control group (5 from major and 5 from minor salivary glands).	Formaldehyde	116-124	catenin beta 1	Homo sapiens	32-44
16377002-2	2006	These experiments were designed to test whether blocking 5HT2A/2c receptors in the CA1 region of the hippocampus and dentate gyrus would decrease nociceptive behaviors induced by a peripheral noxious stimulus formalin as an animal model of unremitting human being.	Formaldehyde	209-217	5-hydroxytryptamine receptor 2A	Rattus norvegicus	57-62
16527403-0	2006	Involvement of cholecystokinin in peripheral nociceptive sensitization during diabetes in rats as revealed by the formalin response.	Formaldehyde	114-122	cholecystokinin	Rattus norvegicus	15-30
17087482-1	2006	Glutathione (GSH)-dependent formaldehyde dehydrogenase (FALDH) is a highly conserved medium-chain dehydrogenase reductase and the main enzyme that metabolizes intracellular formaldehyde in eukaryotes.	Formaldehyde	28-40	GroES-like zinc-binding dehydrogenase family protein	Arabidopsis thaliana	56-61
16869242-6	2006	METHODS: We evaluated the expression of Id2 protein using immunohistochemistry in formalin-fixed, paraffin-embedded specimens from a total of 71 cases of Ewing sarcoma.	Formaldehyde	82-90	inhibitor of DNA binding 2	Homo sapiens	40-43
16377002-2	2006	These experiments were designed to test whether blocking 5HT2A/2c receptors in the CA1 region of the hippocampus and dentate gyrus would decrease nociceptive behaviors induced by a peripheral noxious stimulus formalin as an animal model of unremitting human being.	Formaldehyde	209-217	carbonic anhydrase 1	Homo sapiens	83-86
16627272-6	2006	This study demonstrates that clinical genotyping of the JAK2 V617F mutation can be performed by melting analysis using both freshly isolated and formalin-fixed tissues.	Formaldehyde	145-153	Janus kinase 2	Homo sapiens	56-60
16597366-6	2006	These findings suggest that spinal TRPV1 participates in the transduction system of formalin-evoked pain.	Formaldehyde	84-92	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	35-40
16650113-0	2006	IgE-mediated allergy to formaldehyde from topical application.	Formaldehyde	24-36	immunoglobulin heavy constant epsilon	Homo sapiens	0-3
16616093-2	2006	DESIGN: Immunohistochemical study for p16, pRb, and cyclin D1 proteins in formalin-fixed paraffin-embedded endometriotic and adenomyotic tissues.	Formaldehyde	74-82	cyclin dependent kinase inhibitor 2A	Homo sapiens	38-41
16616093-2	2006	DESIGN: Immunohistochemical study for p16, pRb, and cyclin D1 proteins in formalin-fixed paraffin-embedded endometriotic and adenomyotic tissues.	Formaldehyde	74-82	cyclin D1	Homo sapiens	52-61
16132996-1	2006	AIM: Evaluation of thymidine phosphorylase (TP), dihydropyrimidine dehydrogenase (DPD), and thymidylate synthase (TS) mRNA levels in formalin-fixed, and paraffin-embedded tissues of patients with colorectal cancer and their prognostic and/or predictive value.	Formaldehyde	133-141	dihydropyrimidine dehydrogenase	Homo sapiens	82-85
16132996-1	2006	AIM: Evaluation of thymidine phosphorylase (TP), dihydropyrimidine dehydrogenase (DPD), and thymidylate synthase (TS) mRNA levels in formalin-fixed, and paraffin-embedded tissues of patients with colorectal cancer and their prognostic and/or predictive value.	Formaldehyde	133-141	thymidylate synthetase	Homo sapiens	92-112
16132996-1	2006	AIM: Evaluation of thymidine phosphorylase (TP), dihydropyrimidine dehydrogenase (DPD), and thymidylate synthase (TS) mRNA levels in formalin-fixed, and paraffin-embedded tissues of patients with colorectal cancer and their prognostic and/or predictive value.	Formaldehyde	133-141	thymidylate synthetase	Homo sapiens	114-116
16618609-3	2006	METHODS: Pan mycobacterium primers of the 65-kDa heat shock protein gene (Hsp65) were used in a polymerase chain reaction (PCR) to examine 12 surgically-resected, formalin-fixed, paraffin-embedded specimens from 11 patients with Crohn"s disease.	Formaldehyde	163-171	heat shock protein family D (Hsp60) member 1	Homo sapiens	74-79
16597366-0	2006	Participation of the spinal TRPV1 receptors in formalin-evoked pain transduction: a study using a selective TRPV1 antagonist, iodo-resiniferatoxin.	Formaldehyde	47-55	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	28-33
16597366-1	2006	The involvement of spinal transient receptor potential vanilloid 1 (TRPV1) in formalin-evoked pain has remained unclear, because investigation of this kind of pain with selective antagonists has not been conducted.	Formaldehyde	78-86	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	68-73
16597366-2	2006	The purpose of this study is to investigate the participation of spinal TRPV1 in formalin-evoked pain with iodo-resiniferatoxin (I-RTX), a potent TRPV1-selective antagonist.	Formaldehyde	81-89	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	72-77
16597366-2	2006	The purpose of this study is to investigate the participation of spinal TRPV1 in formalin-evoked pain with iodo-resiniferatoxin (I-RTX), a potent TRPV1-selective antagonist.	Formaldehyde	81-89	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	146-151
16469859-9	2006	Multiplex aQRT-PCR reliably identified the HER-2 gene in microdissected breast cancer samples; in formalin-fixed, paraffin-embedded specimens; and in plasma circulating DNA from cancer patients.	Formaldehyde	98-106	erb-b2 receptor tyrosine kinase 2	Homo sapiens	43-48
16344929-5	2006	Furthermore, expression of Fos protein in the lumbar dorsal horn was immunohistochemically investigated following the injection of formalin into the hindpaw during TMJ inflammation.	Formaldehyde	131-139	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	27-30
16344929-8	2006	The number of Fos-positive neurons in the lumbar dorsal horn ipsilateral to the formalin injection at 1 and 7 days after CFA injection into the TMJ were similar to those in the non-CFA group; however, those were significantly increased in the laminae I-II and V-VI of the lumbar dorsal horn at 14 days after CFA injection.	Formaldehyde	80-88	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	14-17
16369807-4	2006	In addition, galectin-3 expression was evaluated at the protein level by immunohistochemistry in 90 formalin-fixed paraffin-embedded cervical tissues, 10 normal cervical specimens, 20 low-grade squamous intraepithelial lesions (LSILs), 20 high-grade squamous intraepithelial lesions (HSILs), and 40 invasive squamous cell carcinomas (ISCCs).	Formaldehyde	100-108	galectin 3	Homo sapiens	13-23
16507887-5	2006	Overexpression of SSAO activity increased the formation of protein-formaldehyde deposits in tissues.	Formaldehyde	67-79	amine oxidase, copper containing 3	Mus musculus	18-22
16539423-2	2006	This reaction involves the formation of H2CO + HO2 radical in a process that is computed to be exothermic by 57 kcal/mol.	Formaldehyde	40-44	heme oxygenase 2	Homo sapiens	47-50
16187283-6	2006	GABRP downregulation in breast cancer was confirmed by quantitative RT-PCR in cryopreserved breast tumour and normal breast tissue specimens (n = 22), in archival formalin-fixed, paraffin-embedded tissue specimens (n = 32), as well as in breast cancer cell lines (n = 8).	Formaldehyde	163-171	gamma-aminobutyric acid type A receptor subunit pi	Homo sapiens	0-5
16540728-6	2006	At the RNA level TS mRNA expression was measured on formalin-fixed paraffin-embedded tumor tissue and on fresh-frozen tumor tissue by real-time RT-PCR.	Formaldehyde	52-60	thymidylate synthetase	Homo sapiens	17-19
16492833-0	2006	Licking and c-fos expression in the dorsal horn of the spinal cord after the formalin test.	Formaldehyde	77-85	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	12-17
16492833-1	2006	We investigated whether c-fos expression in the dorsal horn is affected by licking in the formalin test.	Formaldehyde	90-98	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	24-29
16492833-8	2006	The results indicated that the licking action increased c-fos expression of the lumbar dorsal horn in the formalin test.	Formaldehyde	106-114	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	56-61
16540728-8	2006	Correlation was found between TS mRNA expression in fresh-frozen tumor tissue and formalin-fixed paraffin-embedded tissue (R=0.71).	Formaldehyde	82-90	thymidylate synthetase	Homo sapiens	30-32
16476080-5	2006	Intra-rACC injection of DAAO (0.1 U) and 7Cl-KYNA (2 and 0.2 mM, 0.6 microL per side) 20 min before F-CPA conditioning greatly attenuated F-CPA scores, but did not affect formalin-induced acute nociceptive behaviors and electric foot shock-induced conditioned place avoidance.	Formaldehyde	171-179	D-amino-acid oxidase	Rattus norvegicus	24-28
16413788-7	2006	Formalin-induced pain behavior was attenuated in the second phase, and this correlated with abolition of NMDA receptor NR1 Ser896/897 phosphorylation and ERK1 and ERK2 activation in the dorsal horn; AMPA receptor phosphorylation (GluR1/Ser831) was unaffected.	Formaldehyde	0-8	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	119-122
16413788-7	2006	Formalin-induced pain behavior was attenuated in the second phase, and this correlated with abolition of NMDA receptor NR1 Ser896/897 phosphorylation and ERK1 and ERK2 activation in the dorsal horn; AMPA receptor phosphorylation (GluR1/Ser831) was unaffected.	Formaldehyde	0-8	mitogen-activated protein kinase 3	Mus musculus	154-158
16413788-7	2006	Formalin-induced pain behavior was attenuated in the second phase, and this correlated with abolition of NMDA receptor NR1 Ser896/897 phosphorylation and ERK1 and ERK2 activation in the dorsal horn; AMPA receptor phosphorylation (GluR1/Ser831) was unaffected.	Formaldehyde	0-8	mitogen-activated protein kinase 1	Mus musculus	163-167
16413788-7	2006	Formalin-induced pain behavior was attenuated in the second phase, and this correlated with abolition of NMDA receptor NR1 Ser896/897 phosphorylation and ERK1 and ERK2 activation in the dorsal horn; AMPA receptor phosphorylation (GluR1/Ser831) was unaffected.	Formaldehyde	0-8	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	230-235
16716036-4	2006	It is suggested that formalin may act as an irritant to produce bronchoconstriction that is mediated by the release of endogenous substance P (SP) from peripheral sensory nerve endings.	Formaldehyde	21-29	tachykinin precursor 1	Homo sapiens	130-141
16480829-2	2006	Results indicate that, compared to hind paw injection of saline, formalin injection in behaving rat evoked biphasic increase in duration of dorsal CA1 theta.	Formaldehyde	65-73	carbonic anhydrase 1	Rattus norvegicus	147-150
16716036-4	2006	It is suggested that formalin may act as an irritant to produce bronchoconstriction that is mediated by the release of endogenous substance P (SP) from peripheral sensory nerve endings.	Formaldehyde	21-29	tachykinin precursor 1	Homo sapiens	143-145
16293369-0	2006	Antinociceptive effects and synergistic interaction with morphine of intrathecal metabotropic glutamate receptor 2/3 antagonist in the formalin test of rats.	Formaldehyde	135-143	glutamate metabotropic receptor 2	Rattus norvegicus	81-114
16432453-7	2006	The expression of COX-2 was determined immunohistochemically in formalin-fixed, paraffin-embedded specimens of 64 human melanocytic skin tumours (17 naevi, 36 primary cutaneous melanomas and 11 lymph node melanoma metastases, with six pairs of primary and metastatic lesions obtained from the same patients).	Formaldehyde	64-72	prostaglandin-endoperoxide synthase 2	Homo sapiens	18-23
16352387-0	2006	Low-dose exposure of intestinal epithelial cells to formaldehyde results in MAP kinase activation and molecular alteration of the focal adhesion protein paxillin.	Formaldehyde	52-64	paxillin	Homo sapiens	153-161
16352387-4	2006	Within 15 min, formaldehyde induced profound tyrosine phosphorylation of the focal adhesion protein paxillin and of proteins at about 120-130 kDa.	Formaldehyde	15-27	paxillin	Homo sapiens	100-108
16427032-4	2006	The enhancement in the number of c-Fos-positive cells in the L4-5 spinal dorsal horn (DH) and the magnitude of paw edema induced by formalin injection during phase II were significantly reduced by minocycline.	Formaldehyde	132-140	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	33-38
16430547-1	2006	BACKGROUND: The analgesic effects of celecoxib, a cyclooxygenase-2 (COX-2) inhibitor, on formalin-induced pain are still controversial.	Formaldehyde	89-97	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	50-66
16430547-1	2006	BACKGROUND: The analgesic effects of celecoxib, a cyclooxygenase-2 (COX-2) inhibitor, on formalin-induced pain are still controversial.	Formaldehyde	89-97	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	68-73
16467085-9	2006	RESULTS: EGFR mutations were detected in 16 of 61 fresh frozen tumor specimens, 24 of 91 dissected formalin-fixed, paraffin-embedded tumor specimens, and 11 of 26 undissected formalin-fixed, paraffin-embedded tumor specimens.	Formaldehyde	99-107	epidermal growth factor receptor	Homo sapiens	9-13
16467085-9	2006	RESULTS: EGFR mutations were detected in 16 of 61 fresh frozen tumor specimens, 24 of 91 dissected formalin-fixed, paraffin-embedded tumor specimens, and 11 of 26 undissected formalin-fixed, paraffin-embedded tumor specimens.	Formaldehyde	175-183	epidermal growth factor receptor	Homo sapiens	9-13
16204226-8	2006	We applied this procedure for detection of Hsp70i in routine sections of breast and lung cancers fixed with 10% formalin and found that the application of thermal antigen retrieval significantly enhanced the SPA810 immunoreactivity and reduced background staining.	Formaldehyde	112-120	heat shock protein family A (Hsp70) member 1A	Homo sapiens	43-49
16484001-9	2006	CONCLUSION: As a result, being cheap and simple methods, Ki-67 and hTERT immunohistochemistries can be used in differentiating malignant and benign mesothelial lesions in routine formalin-fixed, paraffin-embedded material.	Formaldehyde	179-187	telomerase reverse transcriptase	Homo sapiens	67-72
16518578-0	2006	Non-NMDA glutamate receptor antagonist injected into the hypothalamic paraventricular nucleus inhibits the prolactin response to formalin stress of male rats.	Formaldehyde	129-137	glutamate ionotropic receptor NMDA type subunit 2C	Rattus norvegicus	4-27
16427196-8	2006	The possible involvement of cyclooxygenase (COX) isoforms in the IL-1beta-mediated spinal PGE(2) production on the background of peripheral formalin inflammation was further evaluated with the selective COX-1 and COX-2 inhibitors.	Formaldehyde	140-148	interleukin 1 beta	Rattus norvegicus	65-73
16427196-12	2006	Peripheral formalin inflammation in the paw induced a more prolonged effect of spinal IL-1beta with larger PGE(2) releases in the CSF compared with the non-inflammatory state, suggesting that peripheral inflammation enhances central sensitization.	Formaldehyde	11-19	interleukin 1 beta	Rattus norvegicus	86-94
16133360-7	2006	To assess the clonality of the lesions in female patients, the X-linked polymorphic human androgen receptor gene assay was performed using formalin-fixed, paraffin-embedded tissues.	Formaldehyde	139-147	androgen receptor	Homo sapiens	90-107
16427196-14	2006	Our study suggests that mainly the COX-2 enzyme mediates the IL-1beta-induced increase in spinal PGE(2) in the presence of peripheral formalin inflammation.	Formaldehyde	134-142	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	35-40
16427196-14	2006	Our study suggests that mainly the COX-2 enzyme mediates the IL-1beta-induced increase in spinal PGE(2) in the presence of peripheral formalin inflammation.	Formaldehyde	134-142	interleukin 1 beta	Rattus norvegicus	61-69
16438724-3	2006	METHODS: Smad4 expression was investigated by immunohistochemistry in formalin-fixed, paraffin-embedded tissue from 197 samples of primary breast cancer obtained between 1986 and 1998.	Formaldehyde	70-78	SMAD family member 4	Homo sapiens	9-14
16512994-3	2006	PATIENTS AND METHODS: The immunohistochemical expression of HIF-1alpha and VEGF was evaluated in 30 formalin-fixed, paraffin-embedded postoperative rectal adenocarcinoma tissue samples.	Formaldehyde	100-108	hypoxia inducible factor 1 subunit alpha	Homo sapiens	60-70
16426442-3	2006	METHODS: Expression of PTTG-1 was examined immunohistochemically on formalin-fixed, paraffin-embedded tissue sections of 136 patients with small cell lung cancer (SCLC) and 91 patients with non-small cell lung cancer (NSCLC), retrospectively.	Formaldehyde	68-76	PTTG1 regulator of sister chromatid separation, securin	Homo sapiens	23-29
16412244-3	2006	The present studies were undertaken to test the specific role of neuronal ERK in formalin-induced inflammatory pain.	Formaldehyde	81-89	mitogen-activated protein kinase 1	Mus musculus	74-77
16412244-5	2006	RESULTS: Formalin-induced second phase spontaneous pain behaviors as well as thermal hyperalgesia measured 1 - 3 hours post-formalin were significantly reduced in the DN MEK mice when compared to their wild type littermate controls.	Formaldehyde	9-17	midkine	Mus musculus	170-173
16412244-5	2006	RESULTS: Formalin-induced second phase spontaneous pain behaviors as well as thermal hyperalgesia measured 1 - 3 hours post-formalin were significantly reduced in the DN MEK mice when compared to their wild type littermate controls.	Formaldehyde	124-132	midkine	Mus musculus	170-173
16412244-6	2006	In addition, spinal ERK phosphorylation following formalin injection was significantly reduced in the DN MEK mice.	Formaldehyde	50-58	mitogen-activated protein kinase 1	Mus musculus	20-23
16412244-6	2006	In addition, spinal ERK phosphorylation following formalin injection was significantly reduced in the DN MEK mice.	Formaldehyde	50-58	midkine	Mus musculus	105-108
16412244-9	2006	CONCLUSION: Our results demonstrate that the neuronal MEK-ERK pathway is indeed an important intracellular cascade that is associated with formalin-induced inflammatory pain and thermal hyperalgesia.	Formaldehyde	139-147	midkine	Mus musculus	54-57
16412244-9	2006	CONCLUSION: Our results demonstrate that the neuronal MEK-ERK pathway is indeed an important intracellular cascade that is associated with formalin-induced inflammatory pain and thermal hyperalgesia.	Formaldehyde	139-147	mitogen-activated protein kinase 1	Mus musculus	58-61
16360148-4	2006	Prostanoid EP(1) (L-335677), EP(2) (AH 6809), EP(3) (L-826266) and EP(4) (L-161982) receptor antagonists prevented the nociceptive response induced by misoprostol in formalin-injected mice.	Formaldehyde	166-174	prostaglandin E receptor 1 (subtype EP1)	Mus musculus	11-16
16360148-4	2006	Prostanoid EP(1) (L-335677), EP(2) (AH 6809), EP(3) (L-826266) and EP(4) (L-161982) receptor antagonists prevented the nociceptive response induced by misoprostol in formalin-injected mice.	Formaldehyde	166-174	prostaglandin E receptor 3 (subtype EP3)	Mus musculus	46-51
16739311-5	2006	MATERIALS AND METHOD: The protein expression of SMAD4 was evaluated immunohistochemically in 86 formalin-fixed and paraffin-embedded CRC samples.	Formaldehyde	96-104	SMAD family member 4	Homo sapiens	48-53
16424058-4	2006	For this, we generated monoclonal antibodies that detect FGF-BP1 protein in formalin-fixed, paraffin-embedded tissues and applied in situ hybridization to detect FGF-BP1 mRNA in adjacent tissue sections.	Formaldehyde	76-84	fibroblast growth factor binding protein 1	Homo sapiens	57-64
16376485-1	2006	An immunohistochemical analysis with monoclonal antibody p16(INK4a) was performed in formalin-fixed, paraffin-embedded samples of 60 cases.	Formaldehyde	85-93	cyclin dependent kinase inhibitor 2A	Homo sapiens	61-66
17455801-0	2006	Retrospective sequence analysis of the human PRNP gene from the formaldehyde-fixed paraffin-embedded tissues: report of two cases of Creutzfeldt-Jakob disease.	Formaldehyde	64-76	prion protein	Homo sapiens	45-49
16046671-5	2006	Using GI191E/A8, the detection of BCL-6 protein was significantly increased, and its specificity was independent of formalin-fixation time.	Formaldehyde	116-124	BCL6 transcription repressor	Homo sapiens	34-39
16888403-0	2006	Inhalation of low-level formaldehyde increases the Bcl-2/Bax expression ratio in the hippocampus of immunologically sensitized mice.	Formaldehyde	24-36	B cell leukemia/lymphoma 2	Mus musculus	51-56
16888403-0	2006	Inhalation of low-level formaldehyde increases the Bcl-2/Bax expression ratio in the hippocampus of immunologically sensitized mice.	Formaldehyde	24-36	BCL2-associated X protein	Mus musculus	57-60
16761510-4	2006	Upon standard procedure of formalin fixation, embedding in paraffin and examination of slides stained with hematoxillin-eosin, a semiquantitaive method of evaluation of immunohistochemical expression of the HER-2 protein has been performed in all tissue samples of the tumor.	Formaldehyde	27-35	erb-b2 receptor tyrosine kinase 2	Homo sapiens	207-212
16888403-1	2006	OBJECTIVE: A recent study from our research group showed that repeated exposure to low-level formaldehyde (FA) increases the production of nerve growth factor, involving the survival and maintenance of neurons, in the hippocampus of immunized mice.	Formaldehyde	93-105	nerve growth factor	Mus musculus	139-158
16413375-2	2006	METHODS: Morpholine and formaldehyde at different concentrations were added to the solution of prothrombin to cause the conversion of Gla to gamma-methyleneglutamic acid (MGlu).	Formaldehyde	24-36	galactosidase alpha	Homo sapiens	134-137
21176446-4	2006	METHODS: FHIT protein expression was detected in 298 cases of formalin fixed paraffin-embedded human samples by immunohistochemistry, including 51 precancerous lesions, 161 lung cancer samples, 30 normal lung tissue samples, 23 pulmonary benign lesion tissues and 33 metastatic lymph nodes.	Formaldehyde	62-70	fragile histidine triad diadenosine triphosphatase	Homo sapiens	9-13
16366658-1	2005	We present a direct ab initio dynamics study on the hydrogen abstraction reaction CH2O + HO2 --&gt; CHO + H2O2, which is predicted to have four possible reaction channels caused by different attacking orientations of HO2 radical to CH2O.	Formaldehyde	82-86	heme oxygenase 2	Homo sapiens	89-92
16366658-0	2005	Direct dynamics study on the hydrogen abstraction reaction CH2O + HO2 --&gt; CHO + H2O2.	Formaldehyde	59-63	heme oxygenase 2	Homo sapiens	66-69
16174769-1	2005	Human and Escherichia coli derivatives of AlkB enzymes remove methyl groups from 1-methyladenine and 3-methylcytosine in nucleic acids via an oxidative mechanism that releases the methyl group as formaldehyde.	Formaldehyde	196-208	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	42-46
16416732-2	2005	We conducted this study to fully characterize mesothelin expression in surgically resected, formalin-fixed, paraffin-embedded tissue specimens of 18 pancreatic adenocarcinomas, 9 adenocarcinomas of the ampulla of Vater, 12 adenocarcinomas of the common bile duct, and 17 cases of chronic pancreatitis.	Formaldehyde	92-100	mesothelin	Homo sapiens	46-56
16428295-8	2005	On the other hand, only the latter is crosslinked to PDIP38 when mitochondria are treated with a crosslinker, formaldehyde.	Formaldehyde	110-122	DNA polymerase delta interacting protein 2	Homo sapiens	53-59
16296858-4	2005	The compounds are all reduced in multiple one-electron-transfer steps, the first of which involves the M(III)/M(II) process of the porphyrin in the case of (PCY)MClCoCl and the Co(III)/Co(II) process of the corrole in the case of (PCY)H2Co.	Formaldehyde	235-239	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	177-184
16296858-6	2005	Before this study was started, it was expected that the porphyrin-corrole dyads with the largest spacers, namely, O and A, would readily accommodate the formation of cobalt(III) bis-pyridine adducts because of the larger size of the cavity while dyads with the smallest B spacer would seem to have insufficient room to add even a single pyridine within the cavity, as was structurally seen in the case of (PCB)H2Co(py).	Formaldehyde	410-414	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	173-176
16366658-1	2005	We present a direct ab initio dynamics study on the hydrogen abstraction reaction CH2O + HO2 --&gt; CHO + H2O2, which is predicted to have four possible reaction channels caused by different attacking orientations of HO2 radical to CH2O.	Formaldehyde	82-86	heme oxygenase 2	Homo sapiens	217-220
16366658-1	2005	We present a direct ab initio dynamics study on the hydrogen abstraction reaction CH2O + HO2 --&gt; CHO + H2O2, which is predicted to have four possible reaction channels caused by different attacking orientations of HO2 radical to CH2O.	Formaldehyde	232-236	heme oxygenase 2	Homo sapiens	89-92
16366658-1	2005	We present a direct ab initio dynamics study on the hydrogen abstraction reaction CH2O + HO2 --&gt; CHO + H2O2, which is predicted to have four possible reaction channels caused by different attacking orientations of HO2 radical to CH2O.	Formaldehyde	232-236	heme oxygenase 2	Homo sapiens	217-220
16269167-1	2005	The effect of esterified glucomannan on aflatoxin B(1) toxicity in ducklings was studied by immunohistochemical staining of proliferating cell nuclear antigen (PCNA) in hepatic cells on formalin-fixed paraffin-embedded liver samples.	Formaldehyde	186-194	proliferating cell nuclear antigen	Homo sapiens	160-164
15956029-4	2005	When applied to the study of the levels of MRP2, a member of the human multidrug resistance-associated protein family, in samples obtained from formalin-fixed, paraffin-embedded liver biopsies, it allowed the reliable evaluation of the protein content of the tissue.	Formaldehyde	144-152	ATP binding cassette subfamily C member 2	Homo sapiens	43-47
16354354-2	2005	An immunohistochemical technique was employed for detection of PGR- and EGR-specific immunoreactivity in MECh samples using formalin-fixed paraffin-embedded tissue sections.	Formaldehyde	124-132	progesterone receptor	Homo sapiens	63-66
16375215-4	2005	Immunostaining for p53 protein was performed on formalin-fixed, paraffin-embedded tissue sections, using the alkaline phosphatase antialkaline phosphatase (APAAP) method.	Formaldehyde	48-56	tumor protein p53	Homo sapiens	19-22
16315372-5	2005	In our studies of the genetic network under control of the inducible NF-kappaB transcription factor, we found that the conventional ChIP technique using a single formaldehyde cross-linking step did not reproducibly cross-link it to DNA.	Formaldehyde	162-174	nuclear factor kappa B subunit 1	Homo sapiens	69-78
16257284-9	2005	Only combination of chemical addition (e.g. nitric acid or formaldehyde)/refrigeration was found effective to preserve BAS in the short term (e.g. for a week), then losses up to 40% were observed for these target compounds after a month.	Formaldehyde	59-71	BAS	Homo sapiens	119-122
16244004-9	2005	These results suggest that spinal adenosine A1 and A2A receptors may be involved in the modulation of the early and the late phase responses of the formalin test, whereas adenosine A3 receptor may be involved in the regulation of the late phase response.	Formaldehyde	148-156	spectrin, alpha, non-erythrocytic 1	Rattus norvegicus	51-54
16267254-6	2005	METHODS AND RESULTS: In studies with cell types found in vascular tissue, MPO-oxidation products of glycine (formaldehyde) and threonine (acrolein) were the most cytotoxic.	Formaldehyde	109-121	myeloperoxidase	Mus musculus	74-77
16105969-9	2005	CONCLUSION: This is the first localization of CCK1 receptors in human formalin-fixed, paraffin-embedded tissues at the cellular level.	Formaldehyde	70-78	C-C motif chemokine ligand 28	Homo sapiens	46-50
16260273-4	2005	eIF-4E expression was evaluated by immunohistochemistry in 88 formalin-fixed, paraffin-embedded cervical tissues; 10 normal cervical specimens; 19 low-grade cervical intraepithelial neoplasias (CINs); 19 high-grade CINs; and 40 invasive squamous cell carcinomas (ISCCs).	Formaldehyde	62-70	eukaryotic translation initiation factor 4E	Homo sapiens	0-6
16153249-4	2005	Rickettsia inactivation by heat or formaldehyde abolished the activation of p38 kinase and inhibition of cellular invasion by infection at low temperature, pre-treatment of host EC with cytochalasin D, or pre-incubation of rickettsiae with an irreversible phospholipase inhibitor led to a diminished p38 phosphorylation, suggesting requirement of invasion by viable rickettsiae for this host cell response.	Formaldehyde	35-47	mitogen-activated protein kinase 14	Homo sapiens	76-79
16075285-1	2005	RATIONALE: Formalin-induced pain is reduced in sigma-1 (sigma1) receptor knockout mice; therefore, we hypothesized that haloperidol and its metabolites I and II, which have affinity for sigma1 receptors, may modulate formalin-induced pain.	Formaldehyde	11-19	sigma non-opioid intracellular receptor 1	Mus musculus	47-72
16075285-1	2005	RATIONALE: Formalin-induced pain is reduced in sigma-1 (sigma1) receptor knockout mice; therefore, we hypothesized that haloperidol and its metabolites I and II, which have affinity for sigma1 receptors, may modulate formalin-induced pain.	Formaldehyde	217-225	sigma non-opioid intracellular receptor 1	Mus musculus	47-72
16463957-0	2005	Effect of formaldehyde inhalation on Hsp70 in seminiferous tubules of rat testes: an immunohistochemical study.	Formaldehyde	10-22	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	37-42
16463957-1	2005	One parameter which might provide an insight into the underlying mechanism of the effect of formaldehyde (FA) inhalation on testicular tissue, is the assessment of heat shock protein 70 (Hsp70), which increases promptly in cells exposed to stress caused by chemical toxicity.	Formaldehyde	92-104	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	164-185
16463957-1	2005	One parameter which might provide an insight into the underlying mechanism of the effect of formaldehyde (FA) inhalation on testicular tissue, is the assessment of heat shock protein 70 (Hsp70), which increases promptly in cells exposed to stress caused by chemical toxicity.	Formaldehyde	92-104	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	187-192
16212954-3	2005	Mutant mice lacking histidine decarboxylase showed significantly fewer nociceptive responses to the hot-plate, tail-flick, paw-withdrawal, tail-pressure, formalin and capsaicin tests.	Formaldehyde	154-162	histidine decarboxylase	Mus musculus	20-43
16181461-5	2005	A peptide-specific anti-RPE65 antibody was used for immunohistochemical staining of formalin-fixed and paraffin-embedded tissue sections of the respective tumours.	Formaldehyde	84-92	retinoid isomerohydrolase RPE65	Homo sapiens	24-29
16153249-4	2005	Rickettsia inactivation by heat or formaldehyde abolished the activation of p38 kinase and inhibition of cellular invasion by infection at low temperature, pre-treatment of host EC with cytochalasin D, or pre-incubation of rickettsiae with an irreversible phospholipase inhibitor led to a diminished p38 phosphorylation, suggesting requirement of invasion by viable rickettsiae for this host cell response.	Formaldehyde	35-47	mitogen-activated protein kinase 14	Homo sapiens	300-303
16002144-4	2005	BOTOX also dose dependently reduced the number of formalin-induced Fos-like immunoreactive cells in the dorsal horn of the spinal cord and significantly (15 and 30 U/kg) inhibited the excitation of wide dynamic range neurons of the dorsal horn in Phase II but not Phase I of the formalin response.	Formaldehyde	50-58	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	67-70
15719155-3	2005	Early after formalin injection the alpha1-adrenoceptors (mainly alpha1B receptor) binding was reduced in the contralateral hind limb area of the somatosensory cortex and in the secondary motor cortex.	Formaldehyde	12-20	calcium channel, voltage-dependent, N type, alpha 1B subunit	Mus musculus	64-71
15985614-5	2005	Formalin-evoked inflammation produced a 2-fold unilateral increase in NK-1 receptor mRNA levels apparent from 2 to 96 h postinjection.	Formaldehyde	0-8	tachykinin receptor 1	Rattus norvegicus	70-83
16192391-6	2005	The protein levels of both enzymes were not regulated by nociceptive stimuli; however, reduction of cPGES in rat spinal cord with intrathecal application of cPGES antisense oligonucleotides reduced the nociceptive behavior in zymosan-evoked thermal hyperalgesia and in the formalin assay.	Formaldehyde	273-281	prostaglandin E synthase 3	Rattus norvegicus	100-105
16536278-4	2005	RT-PCR was performed in one case using formalin-fixed, paraffin-embedded tissue for EWS-WT1 fusion gene mRNA.	Formaldehyde	39-47	WT1 transcription factor	Homo sapiens	84-91
16536278-24	2005	EWS-WT1 fusion transcript can be detected in formalin-fixed, paraffin-embedded tissue by RT-PCR, which may thus serve as a useful diagnostic adjunct for DSRCT.	Formaldehyde	45-53	WT1 transcription factor	Homo sapiens	0-7
16150545-0	2005	GD3 synthase gene knockout mice exhibit thermal hyperalgesia and mechanical allodynia but decreased response to formalin-induced prolonged noxious stimulation.	Formaldehyde	112-120	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Mus musculus	0-12
16150545-7	2005	Paw edema and Fos expression in the spinal cord after formalin injection were significantly decreased in the mutant mice compared to the wild-type mice.	Formaldehyde	54-62	FBJ osteosarcoma oncogene	Mus musculus	14-17
16277301-0	2005	A DFT theoretical study of the condensation of aggregates of sp2 organolithium compounds on formaldehyde.	Formaldehyde	92-104	Sp2 transcription factor	Homo sapiens	61-64
16277301-1	2005	[Chemical reaction: See text] The interaction between three different sp2 organolithium compounds (vinyllithium, 2-methoxyvinyllithium and phenyllithium) and formaldehyde has been investigated using DFT theoretical methods.	Formaldehyde	158-170	Sp2 transcription factor	Homo sapiens	70-73
16192391-6	2005	The protein levels of both enzymes were not regulated by nociceptive stimuli; however, reduction of cPGES in rat spinal cord with intrathecal application of cPGES antisense oligonucleotides reduced the nociceptive behavior in zymosan-evoked thermal hyperalgesia and in the formalin assay.	Formaldehyde	273-281	prostaglandin E synthase 3	Rattus norvegicus	157-162
16834172-5	2005	Since CH2O is a major product in both reactions, reliable rates for the reaction CH2O + O2 --&gt; HCO + HO2 could be derived from [OH]t and [O]t experiments over the T-range 1587-2109 K. The combined linear least-squares fit result, k = 1.34 x 10(-8) exp(-26883 K/T) cm3 molecule(-1) s(-1), and a recent VTST calculation clearly overlap within the uncertainties in both studies.	Formaldehyde	6-10	EBP cholestenol delta-isomerase	Homo sapiens	81-90
16156633-6	2005	The Co(III) form of the corrole in (PCY)H2Co also appears to be the catalytically active species in the electroreduction of dioxygen, which occurs at potentials associated with the Co(IV)/Co(III) reaction, that is, 0.35 V in 1 M HClO4 as compared to 0.31-0.42 V for the same three dyads in PhCN and 0.1 M TBAP.	Formaldehyde	40-44	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	4-10
16156633-6	2005	The Co(III) form of the corrole in (PCY)H2Co also appears to be the catalytically active species in the electroreduction of dioxygen, which occurs at potentials associated with the Co(IV)/Co(III) reaction, that is, 0.35 V in 1 M HClO4 as compared to 0.31-0.42 V for the same three dyads in PhCN and 0.1 M TBAP.	Formaldehyde	40-44	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	188-194
16834172-5	2005	Since CH2O is a major product in both reactions, reliable rates for the reaction CH2O + O2 --&gt; HCO + HO2 could be derived from [OH]t and [O]t experiments over the T-range 1587-2109 K. The combined linear least-squares fit result, k = 1.34 x 10(-8) exp(-26883 K/T) cm3 molecule(-1) s(-1), and a recent VTST calculation clearly overlap within the uncertainties in both studies.	Formaldehyde	6-10	heme oxygenase 2	Homo sapiens	104-107
16041397-9	2005	Furthermore, this utilization of the central opioid system could be initiated by antagonism of spinal P2X3/P2X2/3 receptors since the antinociceptive actions of intrathecally delivered A-317491 (30 nmol) in the formalin model were reduced by both intrathecally (10-50 nmol) and systemically (10 mg kg(-1), i.p.)	Formaldehyde	211-219	purinergic receptor P2X 3	Rattus norvegicus	102-106
16137526-2	2005	MATERIAL AND METHODS: MIB-1 monoclonal antibody was used for comparative assessment of proliferative activity of middle ear cholesteatoma, external auditory canal skin, and retroauricular skin samples on formalin-fixed paraffin-embedded tissue sections.	Formaldehyde	204-212	MIB E3 ubiquitin protein ligase 1	Homo sapiens	22-27
16082258-0	2005	A simple antigen retrieval method for the optimal demonstration of cyclin-D1 overexpression in formalin-fixed paraffin-embedded cases of mantle cell lymphoma.	Formaldehyde	95-103	cyclin D1	Homo sapiens	67-76
16082258-3	2005	However, demonstration of cyclin D1 by immunohistochemistry on formalin-fixed, paraffin-embedded tissue is often fraught with technical difficulties, chiefly poor staining intensity largely due to insufficient antigen retrieval.	Formaldehyde	63-71	cyclin D1	Homo sapiens	26-35
15994850-4	2005	Intraplantar administration of formalin mimicked inflammatory pain, and its effects were assessed using immunohistochemical (c-Fos staining) and behavioural paradigms.	Formaldehyde	31-39	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	125-130
16041397-9	2005	Furthermore, this utilization of the central opioid system could be initiated by antagonism of spinal P2X3/P2X2/3 receptors since the antinociceptive actions of intrathecally delivered A-317491 (30 nmol) in the formalin model were reduced by both intrathecally (10-50 nmol) and systemically (10 mg kg(-1), i.p.)	Formaldehyde	211-219	purinergic receptor P2X 2	Rattus norvegicus	107-113
15961431-9	2005	P2X2-/- and P2X2/P2X3(Dbl-/-) mice had reduced pain-related behaviours in response to intraplantar injection of formalin.	Formaldehyde	112-120	purinergic receptor P2X, ligand-gated ion channel, 2	Mus musculus	0-4
15961431-9	2005	P2X2-/- and P2X2/P2X3(Dbl-/-) mice had reduced pain-related behaviours in response to intraplantar injection of formalin.	Formaldehyde	112-120	purinergic receptor P2X, ligand-gated ion channel, 2	Mus musculus	12-16
15961431-9	2005	P2X2-/- and P2X2/P2X3(Dbl-/-) mice had reduced pain-related behaviours in response to intraplantar injection of formalin.	Formaldehyde	112-120	purinergic receptor P2X, ligand-gated ion channel, 3	Mus musculus	17-21
16098663-3	2005	Intra-articular injection of 100 pg or 1 ng of IL-1beta significantly facilitated formalin-induced behavior by 130 or 174% in the number of scratches.	Formaldehyde	82-90	interleukin 1 beta	Rattus norvegicus	47-55
16098663-4	2005	Intracisternal administration of 100 pg or 1 ng of IL-1beta also significantly increased formalin-induced behavior by 166 or 82% in the number of scratches.	Formaldehyde	89-97	interleukin 1 beta	Rattus norvegicus	51-59
16173582-1	2005	A novel method determining compound-specific carbon isotopic compositions for atmospheric formaldehyde and acetaldehyde in ppb or sub-ppb levels by gas chromatography/ combustion/isotope ratio mass spectrometry (GC/C/ IRMS) is presented.	Formaldehyde	90-102	guanylate cyclase 2C	Homo sapiens	212-216
16116038-5	2005	Formaldehyde cross-linking of cytochalasin B- and proteinase K-treated mitochondria further revealed that actin was associated with DNA in nucleoids.	Formaldehyde	0-12	actin	Vigna radiata	106-111
16157025-16	2005	CONCLUSIONS: Molecular detection of EWS-Fli1 fusion transcripts in formalin-fixed paraffin-embedded material by nested RT-PCR is feasible and is useful for the diagnosis and differential diagnosis of ES/pPNETs.	Formaldehyde	67-75	EWS RNA binding protein 1	Homo sapiens	36-39
16157025-16	2005	CONCLUSIONS: Molecular detection of EWS-Fli1 fusion transcripts in formalin-fixed paraffin-embedded material by nested RT-PCR is feasible and is useful for the diagnosis and differential diagnosis of ES/pPNETs.	Formaldehyde	67-75	Fli-1 proto-oncogene, ETS transcription factor	Homo sapiens	40-44
16080910-5	2005	Subcellular localization of ERbeta isoforms was determined on formaldehyde-fixed, Saponin-permeabilized cells using conventional immunofluorescence techniques and affinity purified polyclonal antibodies specific for ERbeta-1 as well as to two of the truncated carboxy terminus isoforms (beta-2 and beta-5).	Formaldehyde	62-74	estrogen receptor 2	Homo sapiens	28-34
16155800-0	2005	A multi-centre investigation towards reaching a consensus on the immunohistochemical detection of ERbeta in archival formalin-fixed paraffin embedded human breast tissue.	Formaldehyde	117-125	estrogen receptor 2	Homo sapiens	98-104
16051814-0	2005	Formaldehyde-treated, heat-inactivated virions with increased human immunodeficiency virus type 1 env can be used to induce high-titer neutralizing antibody responses.	Formaldehyde	0-12	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	98-101
16055749-0	2005	Apolipoprotein D expression in primary brain tumors: analysis by quantitative RT-PCR in formalin-fixed, paraffin-embedded tissue.	Formaldehyde	88-96	apolipoprotein D	Homo sapiens	0-16
16055749-2	2005	ApoD expression was investigated by real-time quantitative RT-PCR using RNA extracted from 68 formalin-fixed, paraffin-embedded brain specimens.	Formaldehyde	94-102	apolipoprotein D	Homo sapiens	0-4
15934011-0	2005	Protective effect of NAC on formaldehyde-containing-ZOE-based root-canal-sealers-induced cyclooxygenase-2 expression and cytotoxicity in human osteoblastic cells.	Formaldehyde	28-40	X-linked Kx blood group	Homo sapiens	21-24
15934011-0	2005	Protective effect of NAC on formaldehyde-containing-ZOE-based root-canal-sealers-induced cyclooxygenase-2 expression and cytotoxicity in human osteoblastic cells.	Formaldehyde	28-40	prostaglandin-endoperoxide synthase 2	Homo sapiens	89-105
15934011-3	2005	However, little is known about whether chemical interaction can modulate the COX-2 expression and cytotoxicity induced by formaldehyde-containing-ZOE-based root canal sealers.	Formaldehyde	122-134	prostaglandin-endoperoxide synthase 2	Homo sapiens	77-82
15934011-5	2005	Our data demonstrated that both formaldehyde-containing-ZOE-based root canal sealers were found to induce COX-2 mRNA gene expression in U2OS cells.	Formaldehyde	32-44	prostaglandin-endoperoxide synthase 2	Homo sapiens	106-111
15934011-8	2005	The data presented here demonstrated that the activation of COX-2 mRNA gene expression may be one of the pathogenesis of formaldehyde-containing-ZOE-based root-canal-sealers-induced periapical inflammation.	Formaldehyde	121-133	prostaglandin-endoperoxide synthase 2	Homo sapiens	60-65
15934011-9	2005	In addition, GSH depletion, but not the attack of oxygen free radicals, could be the mechanism for cytotoxicity and COX-2 mRNA gene expression induced by formaldehyde-containing-ZOE-based root canal sealers.	Formaldehyde	154-166	prostaglandin-endoperoxide synthase 2	Homo sapiens	116-121
15934011-10	2005	NAC appears as a useful agent in protecting cell damage mediated by formaldehyde-containing-ZOE-based root canal sealers.	Formaldehyde	68-80	X-linked Kx blood group	Homo sapiens	0-3
16839062-5	2005	In the reactions CH2Cl + NO2, CHCl2 + NO2, and CCl3 + NO2, the products observed are formaldehyde, CHClO, and phosgene (CCl2O), respectively.	Formaldehyde	85-97	C-C motif chemokine ligand 3	Homo sapiens	47-51
16038038-5	2005	In situ hybridization was done to examine the messenger RNA expression of ICAM-1 in formalin-fixed, paraffin-embedded sections using peptide nucleic acid probes and the catalyzed signal amplification (CSA) technique.	Formaldehyde	84-92	intercellular adhesion molecule 1	Homo sapiens	74-80
15657722-5	2005	When 10 mM formaldehyde was treated with the aldehyde oxidase in the presence of catalase for 240 min, the formaldehyde concentration was reduced to 0.8 mM, suggesting this enzyme might be effective for the removal of formaldehyde contained in wastewater.	Formaldehyde	11-23	xanthine dehydrogenase family protein molybdopterin-binding subunit	Pseudomonas stutzeri	45-61
15657722-5	2005	When 10 mM formaldehyde was treated with the aldehyde oxidase in the presence of catalase for 240 min, the formaldehyde concentration was reduced to 0.8 mM, suggesting this enzyme might be effective for the removal of formaldehyde contained in wastewater.	Formaldehyde	107-119	xanthine dehydrogenase family protein molybdopterin-binding subunit	Pseudomonas stutzeri	45-61
15657722-5	2005	When 10 mM formaldehyde was treated with the aldehyde oxidase in the presence of catalase for 240 min, the formaldehyde concentration was reduced to 0.8 mM, suggesting this enzyme might be effective for the removal of formaldehyde contained in wastewater.	Formaldehyde	107-119	xanthine dehydrogenase family protein molybdopterin-binding subunit	Pseudomonas stutzeri	45-61
16001656-6	2005	The immunohistochemical method determined protein p53 in formalin-fixed, paraffin-embedded liver tissue sections.	Formaldehyde	57-65	tumor protein p53	Homo sapiens	50-53
15968072-5	2005	Four genes, a homolog of pabB, and three genes conserved between methanogenic Archaea and Bacteria possessing H(4)MPT-linked functions, orfY, orf1, and afpA were shown to be involved in formaldehyde oxidation/detoxification, as judged by specific mutant phenotypes.	Formaldehyde	186-198	ORF1	Homo sapiens	142-146
15761875-1	2005	In peptide synthesis, the use of N(alpha)-tert-butyloxycarbonyl-N(pi)-benzyloxymethylhistidine [Boc-His(pi-Bom)] raises the problem of the Bom group generating formaldehyde during the hydrogen fluoride (HF) cleavage reaction.	Formaldehyde	160-172	BOC cell adhesion associated, oncogene regulated	Homo sapiens	96-99
15925144-5	2005	Intracisternal administration of MCP-1, Rantes or IL-8 significantly increased formalin-induced scratching behavioral responses in the orofacial area.	Formaldehyde	79-87	mast cell protease 1-like 1	Rattus norvegicus	33-38
15925144-5	2005	Intracisternal administration of MCP-1, Rantes or IL-8 significantly increased formalin-induced scratching behavioral responses in the orofacial area.	Formaldehyde	79-87	C-C motif chemokine ligand 5	Rattus norvegicus	40-46
15782116-3	2005	In addition, we used a sensitive RT-PCR strategy to define the expression of SEPT9 isoforms in archival formalin-fixed and paraffin-embedded normal human tissues.	Formaldehyde	104-112	septin 9	Homo sapiens	77-82
16051541-0	2005	c-Fos antisense oligodeoxynucleotide offsets behavioral nociceptive responses and both up-regulations of c-Fos protein and dynorphin a (1-8) in dorsal horn: a study using the formalin test in rats.	Formaldehyde	175-183	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-5
15910293-2	2005	CXCR3 expression was localized in formalin-fixed, paraffin-embedded renal allograft biopsies without signs of rejection (C4d-negative, Banff 0, n = 16), with C4d deposits as a sign of humoral rejection (C4d-positive, Banff 0, n = 8), with cellular rejection (C4d-negative, Banff I, n = 7) and with signs of both cellular and humoral rejection (C4d-positive, Banff 1, n = 5).	Formaldehyde	34-42	C-X-C motif chemokine receptor 3	Homo sapiens	0-5
15968330-5	2005	CONCLUSION: The analysis of the EWS-WT1 fusion transcript which was performed on formalin-fixed, paraffin-embedded tissues is a sensitive and specific method in the diagnosis and differential diagnosis of DSRCT.	Formaldehyde	81-89	WT1 transcription factor	Homo sapiens	32-39
16833839-3	2005	The emission spectra and theoretical calculations indicate that HCN + CH2O is the only significant product channel for the C2H3 + NO reaction near room temperature, in contradiction to several reports in the literature.	Formaldehyde	70-74	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	64-67
15944015-6	2005	(3) Formalin-induced flinching: Formalin paw injection (2.5%/20 microl) produced a two-phase flinching in both GalR1 KO and WT groups, that was detected by an automated flinching sensor device.	Formaldehyde	4-12	galanin receptor 1	Mus musculus	111-116
15944015-6	2005	(3) Formalin-induced flinching: Formalin paw injection (2.5%/20 microl) produced a two-phase flinching in both GalR1 KO and WT groups, that was detected by an automated flinching sensor device.	Formaldehyde	32-40	galanin receptor 1	Mus musculus	111-116
15967901-8	2005	MAIN OUTCOME MEASURES: CD117 and ras p21 were stained by immunohistochemistry on formalin-fixed, paraffin-embedded sections of normal and tumor tissues.	Formaldehyde	81-89	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	23-28
15772955-4	2005	COX-2 expression was determined by immunohistochemical staining of formalin-fixed, paraffin-embedded tumor tissue.	Formaldehyde	67-75	prostaglandin-endoperoxide synthase 2	Homo sapiens	0-5
15906292-4	2005	After formalin fixation, Tr(D) was reduced 30-80%.	Formaldehyde	6-14	t-complex distorter 1A	Mus musculus	25-30
15910798-1	2005	We studied the effects of the high-efficacy 5-hydroxytryptamine1A (5-HT1A) receptor agonist, F 13640 on both formalin-induced spinal cord c-Fos protein expression and pain behaviours in the rat.	Formaldehyde	109-117	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	138-143
15910767-7	2005	injection of either NPW23 or NPB decreased the number of agitation behaviors induced by paw formalin injection and attenuated the level of mechanical allodynia, but not the level of thermal hyperalgesia, induced by paw carrageenan injection in a dose-dependent manner at a dose between 0.1 and 10 microg, significantly.	Formaldehyde	92-100	neuropeptide B	Rattus norvegicus	29-32
15910767-14	2005	injection of either 10 microg of NPW23 or 10 microg of NPB significantly suppressed the expression of Fos-like immunoreactivity of the L4-5 spinal dorsal horn induced by paw formalin injection.	Formaldehyde	174-182	neuropeptide B	Rattus norvegicus	55-58
15910767-14	2005	injection of either 10 microg of NPW23 or 10 microg of NPB significantly suppressed the expression of Fos-like immunoreactivity of the L4-5 spinal dorsal horn induced by paw formalin injection.	Formaldehyde	174-182	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	102-105
15910767-15	2005	These data suggest that both spinally-applied NPW23 and NPB suppressed the input of nociceptive information to the spinal dorsal horn, produced an analgesic effect in the formalin test, and attenuated the level of mechanical allodynia in the carrageenan test, and that either spinally applied NPW23 or spinally applied NPB had no effect in the physiological condition.	Formaldehyde	171-179	neuropeptide B	Rattus norvegicus	56-59
15910798-4	2005	In the same animals, and in spite of the agent as in earlier data increasing the number of c-Fos labelled nuclei when it was administered alone, F 13640 markedly reduced the number of formalin-induced c-Fos labelled nuclei.	Formaldehyde	184-192	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	201-206
15910798-6	2005	Co-operation occurred so that after the co-administration of F 13640 and formalin, c-Fos expression was inferior to that induced when either stimulation was administered alone.	Formaldehyde	73-81	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	83-88
15914300-8	2005	Antibodies against platelet glycoprotein IIIa (CD61) and fibrin II were applied to formalin fixed tissue sections and detected by the avidin biotin techniques, and platelet and fibrin capillary thrombi were quantitated.	Formaldehyde	83-91	integrin subunit beta 3	Homo sapiens	47-51
15956752-4	2005	Tissues were fixed in 10% neutral buffered formalin, and utilizing two different antibodies to relaxin-like factor, W3 rabbit anti-bovine and 2-8F mouse anti-bovine, relaxin-like factor was localized in fibroblast-like cells.	Formaldehyde	43-51	insulin like 3	Bos taurus	166-185
15820619-1	2005	Formaldehyde (FA) can cause severe central nervous system impairment.	Formaldehyde	0-12	FAT atypical cadherin 1	Rattus norvegicus	14-16
15898937-7	2005	ALP activity was assessed using p-nitrophenylphosphate with formalin-fixed cells, and cellular DNA content was subsequently quantified using bis-benzimide.	Formaldehyde	60-68	alkaline phosphatase, placental	Homo sapiens	0-3
15605081-3	2005	By using in situ hybridization and immunohistochemistry, dlk mRNA and protein expression were studied in formalin-fixed archival tissues from 10 patients with neuroblastoma, five with ganglioneuroblastoma, and five with ganglioneuroma.	Formaldehyde	105-113	mitogen-activated protein kinase kinase kinase 12	Homo sapiens	57-60
15836980-0	2005	Essential role of the synaptic vesicle protein synapsin II in formalin-induced hyperalgesia and glutamate release in the spinal cord.	Formaldehyde	62-70	synapsin II	Mus musculus	47-58
15836980-7	2005	In addition, the formalin evoked increase in the number of c-Fos IR neurons is significantly reduced in synapsin II knockout mice.	Formaldehyde	17-25	FBJ osteosarcoma oncogene	Mus musculus	59-64
15836980-7	2005	In addition, the formalin evoked increase in the number of c-Fos IR neurons is significantly reduced in synapsin II knockout mice.	Formaldehyde	17-25	synapsin II	Mus musculus	104-115
15836981-5	2005	Our first studies focused on the ability of the selective CK2 inhibitors 4,5,6,7-tetrabromobenzotriazole (TBBT) and 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) to reduce formalin-stimulated pain behaviors in mice.	Formaldehyde	181-189	casein kinase 2, alpha prime polypeptide	Mus musculus	58-61
15817147-1	2005	The present study was designed to evaluate the efficacy of different microwave pretreatment methods to retrieve microtubule-associated protein 2 (MAP-2) immunoreactivity in formalin-fixed, paraffin-embedded guinea pig brain sections.	Formaldehyde	173-181	microtubule-associated protein 2	Cavia porcellus	112-144
15951858-4	2005	METHODS: Immunohistochemistry using the avidin-biotin peroxidase complex technique with a polyclonal antibody against the nm23 protein was applied to formalin-fixed, paraffin-embedded tissue specimens obtained from 48 patients.	Formaldehyde	150-158	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	122-126
18970030-6	2005	A detection limit of 41ppb of formaldehyde was calculated and an operational stability of 6h was achieved under flow conditions by means of this novel amperometric biosensor based on FDH-semiconductor hybrid systems, not requiring NAD(+)/NADH as charge transfer in the enzymatic reaction.	Formaldehyde	30-42	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	183-186
15785748-7	2005	Owing to its potential as a novel therapeutic marker, expression of the high-affinity epithelial receptor for Clostridium perfringens enterotoxin (CPE) claudin-4 was further validated through immunohistochemical analysis of formalin-fixed paraffin-embedded specimens from which the primary USPC cultures were obtained, as well as an independent set of archival USPC specimens.	Formaldehyde	224-232	cpe	Clostridium perfringens	110-145
15785748-7	2005	Owing to its potential as a novel therapeutic marker, expression of the high-affinity epithelial receptor for Clostridium perfringens enterotoxin (CPE) claudin-4 was further validated through immunohistochemical analysis of formalin-fixed paraffin-embedded specimens from which the primary USPC cultures were obtained, as well as an independent set of archival USPC specimens.	Formaldehyde	224-232	cpe	Clostridium perfringens	147-150
15785748-7	2005	Owing to its potential as a novel therapeutic marker, expression of the high-affinity epithelial receptor for Clostridium perfringens enterotoxin (CPE) claudin-4 was further validated through immunohistochemical analysis of formalin-fixed paraffin-embedded specimens from which the primary USPC cultures were obtained, as well as an independent set of archival USPC specimens.	Formaldehyde	224-232	claudin 4	Homo sapiens	152-161
15763162-7	2005	Immunoperoxidase immunohistochemistry of formalin-fixed tissue also confirmed the presence of many C9-positive cells, particularly in the hippocampus.	Formaldehyde	41-49	complement C9	Homo sapiens	99-101
15896802-7	2005	To overcome this limitation, we have developed a simple and reproducible method to generate APM component-specific mAb which stain formalin-fixed, paraffin-embedded tissue sections.	Formaldehyde	131-139	alanyl (membrane) aminopeptidase	Mus musculus	92-95
15896802-9	2005	The use of the methodology we have developed resulted in the generation of a panel of APM component-specific mAb capable of staining formalin-fixed, paraffin-embedded tissue sections in IHC reactions.	Formaldehyde	133-141	alanyl (membrane) aminopeptidase	Mus musculus	86-89
15732141-4	2005	To overcome this problem, an AID-specific monoclonal antibody suitable for immunohistochemical staining of formalin-fixed, paraffin wax-embedded tissue sections has been generated.	Formaldehyde	107-115	activation induced cytidine deaminase	Homo sapiens	29-32
15817147-1	2005	The present study was designed to evaluate the efficacy of different microwave pretreatment methods to retrieve microtubule-associated protein 2 (MAP-2) immunoreactivity in formalin-fixed, paraffin-embedded guinea pig brain sections.	Formaldehyde	173-181	microtubule-associated protein 2	Cavia porcellus	146-151
15722793-4	2005	In this study, the immunohistochemical expression of the deleted in colorectal cancer gene (DCC) and p27Kip1 was assessed in 168 paraffin-embedded, formalin-fixed tumors of patients with stage II and III colorectal cancer.	Formaldehyde	148-156	DCC netrin 1 receptor	Homo sapiens	92-95
16091175-7	2005	Immunohistochemical staining demonstrated that G3BP was over-expressed in formalin-fixed and paraffin-embedded tissues of some human tumors, such as lung cancer, colon cancer, gastric cancer and breast cancer.	Formaldehyde	74-82	G3BP stress granule assembly factor 1	Homo sapiens	47-51
15777781-0	2005	Formalin-induced pain is reduced in sigma(1) receptor knockout mice.	Formaldehyde	0-8	sigma non-opioid intracellular receptor 1	Mus musculus	36-53
15777781-2	2005	In this study we show that both phases of formalin-induced pain were reduced by approximately 55% in sigma1 receptor knockout mice in comparison to wild-type animals.	Formaldehyde	42-50	sigma non-opioid intracellular receptor 1	Mus musculus	101-116
15722800-0	2005	Development of new rabbit monoclonal antibody to estrogen receptor: immunohistochemical assessment on formalin-fixed, paraffin-embedded tissue sections.	Formaldehyde	102-110	estrogen receptor 1	Homo sapiens	49-66
15578220-4	2005	Methanol is metabolised in the liver by alcohol dehydrogenase to the toxic metabolites formaldehyde and formic acid.	Formaldehyde	87-99	aldo-keto reductase family 1 member A1	Homo sapiens	40-61
15830090-8	2005	Reduction of formalin-induced pain suggests direct analgesic BT effects possibly mediated through blockade of substance P, glutamate and calcitonin gene related peptide.	Formaldehyde	13-21	tachykinin precursor 1	Homo sapiens	110-121
16335684-8	2005	Immunohistochemical staining for Tg was performed on formalin-fixed, paraffin-embedded sections with anti-Tg antibodies.	Formaldehyde	53-61	thyroglobulin	Homo sapiens	33-35
15668953-1	2005	BACKGROUND: For 4 years we used a multiparameter DNA flow cytometric (MP-FCM) technique to assess steroid hormone receptor expression in the diagnostic workup of routinely processed formalin-fixed, paraffin-embedded breast carcinomas as an alternative to immunohistochemistry (IHC) for the quantification of hormone receptor-positive cells.	Formaldehyde	182-190	nuclear receptor subfamily 4 group A member 1	Homo sapiens	106-122
15943037-3	2005	The aim of this study was to assess EGFR expression in human high-grade astrocytomas by means of immunohistochemistry on formalin-fixed, paraffin-embedded sections and to compare these findings with the results of our previous study on frozen sections from these tumours, in which we found about 60% EGFR positivity (10).	Formaldehyde	121-129	epidermal growth factor receptor	Homo sapiens	36-40
15735170-5	2005	RESULTS: MCM-2 staining was completely negative in Bouin"s fixed tissues, whereas p27 showed more background and excess cytoplasmic staining in Bouin"s fixed versus formalin fixed tissues.	Formaldehyde	165-173	interferon alpha inducible protein 27	Homo sapiens	82-85
15731053-4	2005	We examined the contribution of Toll-like receptors (TLR) and MyD88 in macrophage responses to formalin-killed spherules (FKS) by comparing cytokine responses of elicited macrophages from different knockout mice.	Formaldehyde	95-103	myeloid differentiation primary response gene 88	Mus musculus	62-67
15748168-5	2005	In these rats, down-regulation of spinal p38beta, but not p38alpha, prevented nocifensive flinching evoked by intraplantar injection of formalin and hyperalgesia induced by activation of spinal neurokinin-1 receptors through intrathecal injection of substance P. Both intraplantar formalin and intrathecal substance P produced an increase in spinal p38 phosphorylation and this phosphorylation (activation) was prevented when spinal p38beta, but not p38alpha, was down-regulated.	Formaldehyde	136-144	mitogen-activated protein kinase 11	Rattus norvegicus	41-48
15748168-5	2005	In these rats, down-regulation of spinal p38beta, but not p38alpha, prevented nocifensive flinching evoked by intraplantar injection of formalin and hyperalgesia induced by activation of spinal neurokinin-1 receptors through intrathecal injection of substance P. Both intraplantar formalin and intrathecal substance P produced an increase in spinal p38 phosphorylation and this phosphorylation (activation) was prevented when spinal p38beta, but not p38alpha, was down-regulated.	Formaldehyde	136-144	mitogen activated protein kinase 14	Rattus norvegicus	41-44
15748168-5	2005	In these rats, down-regulation of spinal p38beta, but not p38alpha, prevented nocifensive flinching evoked by intraplantar injection of formalin and hyperalgesia induced by activation of spinal neurokinin-1 receptors through intrathecal injection of substance P. Both intraplantar formalin and intrathecal substance P produced an increase in spinal p38 phosphorylation and this phosphorylation (activation) was prevented when spinal p38beta, but not p38alpha, was down-regulated.	Formaldehyde	281-289	mitogen-activated protein kinase 11	Rattus norvegicus	41-48
15748168-5	2005	In these rats, down-regulation of spinal p38beta, but not p38alpha, prevented nocifensive flinching evoked by intraplantar injection of formalin and hyperalgesia induced by activation of spinal neurokinin-1 receptors through intrathecal injection of substance P. Both intraplantar formalin and intrathecal substance P produced an increase in spinal p38 phosphorylation and this phosphorylation (activation) was prevented when spinal p38beta, but not p38alpha, was down-regulated.	Formaldehyde	281-289	mitogen activated protein kinase 14	Rattus norvegicus	41-44
15733652-5	2005	Whereas serotonin and CGRP immunoreactivities were comparable in WT and ArKO non-injected control groups, our data showed that 9 min after formalin injection, the density of serotoninergic terminals increased significantly in WT, but not in ArKO mice, while that of CGRP-immunoreactive fibers was lower in WT than in ArKO mice on the injected side.	Formaldehyde	139-147	cytochrome P450, family 19, subfamily a, polypeptide 1	Mus musculus	72-76
15805735-4	2005	We found that the number of corticotropin releasing hormone (CRH)-immunoreactive (ir) neurons was up-regulated according to the amount of formaldehyde as well as inhalation of formaldehyde alone in our previous experiment.	Formaldehyde	138-150	corticotropin releasing hormone	Mus musculus	28-59
15805735-4	2005	We found that the number of corticotropin releasing hormone (CRH)-immunoreactive (ir) neurons was up-regulated according to the amount of formaldehyde as well as inhalation of formaldehyde alone in our previous experiment.	Formaldehyde	138-150	corticotropin releasing hormone	Mus musculus	61-64
15805735-4	2005	We found that the number of corticotropin releasing hormone (CRH)-immunoreactive (ir) neurons was up-regulated according to the amount of formaldehyde as well as inhalation of formaldehyde alone in our previous experiment.	Formaldehyde	176-188	corticotropin releasing hormone	Mus musculus	28-59
15805735-4	2005	We found that the number of corticotropin releasing hormone (CRH)-immunoreactive (ir) neurons was up-regulated according to the amount of formaldehyde as well as inhalation of formaldehyde alone in our previous experiment.	Formaldehyde	176-188	corticotropin releasing hormone	Mus musculus	61-64
15805735-5	2005	The proportion of adrenocorticotropin hormone (ACTH)-ir cells increased according to the formaldehyde concentration, though there was no significant difference between the 400 and 2,000 groups.	Formaldehyde	89-101	pro-opiomelanocortin-alpha	Mus musculus	47-51
15805735-7	2005	Expression of ACTH-mRNA was also up-regulated according to the quantity of formaldehyde.	Formaldehyde	75-87	pro-opiomelanocortin-alpha	Mus musculus	14-18
15735574-6	2005	We also developed a method useful for RT-PCR SYT-SSX fusion transcript detection in formalin-fixed, paraffin-embedded tissue.	Formaldehyde	84-92	synaptotagmin 1	Homo sapiens	45-48
15941514-4	2005	Streptavidin-peroxidase immunohistochemical technique was used to detect the expression of p53, C-erbB-2, nm23-H(1) and Ras on formalin-fixed, paraffin embedded sections of CRC from the 120 patients.	Formaldehyde	127-135	tumor protein p53	Homo sapiens	91-94
15740792-8	2005	Immunocytochemistry, histochemistry and western blot were performed to determine the effect of midazolam on formalin-induced expression of Fos protein, nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) and nitric oxide synthase (NOS) in chronic morphine-tolerant rats, respectively.	Formaldehyde	108-116	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	139-142
15740792-10	2005	In chronic morphine-tolerant rats, pretreatment with midazolam significantly decreased the formalin-induced expression of Fos and Fos/NADPH-d double-labeled neurons in the contralateral spinal cord and NADPH-d positive neurons in the bilateral spinal cord.	Formaldehyde	91-99	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	122-125
15740792-10	2005	In chronic morphine-tolerant rats, pretreatment with midazolam significantly decreased the formalin-induced expression of Fos and Fos/NADPH-d double-labeled neurons in the contralateral spinal cord and NADPH-d positive neurons in the bilateral spinal cord.	Formaldehyde	91-99	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	130-133
15740792-11	2005	Both inducible NOS (iNOS) and neuronal NOS (nNOS) protein levels in the spinal cord were significantly increased after injection of formalin, which could be inhibited by pretreatment with midazolam.	Formaldehyde	132-140	nitric oxide synthase 2	Rattus norvegicus	5-18
15740792-11	2005	Both inducible NOS (iNOS) and neuronal NOS (nNOS) protein levels in the spinal cord were significantly increased after injection of formalin, which could be inhibited by pretreatment with midazolam.	Formaldehyde	132-140	nitric oxide synthase 2	Rattus norvegicus	20-24
15740792-11	2005	Both inducible NOS (iNOS) and neuronal NOS (nNOS) protein levels in the spinal cord were significantly increased after injection of formalin, which could be inhibited by pretreatment with midazolam.	Formaldehyde	132-140	nitric oxide synthase 1	Rattus norvegicus	30-42
15740792-11	2005	Both inducible NOS (iNOS) and neuronal NOS (nNOS) protein levels in the spinal cord were significantly increased after injection of formalin, which could be inhibited by pretreatment with midazolam.	Formaldehyde	132-140	nitric oxide synthase 1	Rattus norvegicus	44-48
15682491-2	2005	METHODS: NF-kappaB activation was assayed by immunohistochemical staining in formalin-fixed, paraffin-embedded specimens from 45 gastric carcinoma patients.	Formaldehyde	77-85	nuclear factor kappa B subunit 1	Homo sapiens	9-18
15715472-10	2005	The butyric acid and formaldehyde induced cell differentiation and increased p53 and p21 levels, suggesting that both affect cancer cells, the acid by inhibiting HDAC and the aldehyde by an as yet unknown mechanism.	Formaldehyde	21-33	tumor protein p53	Homo sapiens	77-80
15715472-10	2005	The butyric acid and formaldehyde induced cell differentiation and increased p53 and p21 levels, suggesting that both affect cancer cells, the acid by inhibiting HDAC and the aldehyde by an as yet unknown mechanism.	Formaldehyde	21-33	H3 histone pseudogene 16	Homo sapiens	85-88
15644781-6	2005	Using a polyclonal antibody to TFEB on formalin-fixed, paraffin-embedded tissue sections, we found that all 7 renal neoplasms with the t(6;11) demonstrated moderate (2 cases) or strong (5 cases) nuclear TFEB immunoreactivity.	Formaldehyde	39-47	transcription factor EB	Homo sapiens	31-35
15659113-1	2005	AIM: To investigate effects of the cyclin-dependent kinase5 (Cdk5) inhibitor roscovitine on formalin-induced nociceptive responses in rats.	Formaldehyde	92-100	cyclin-dependent kinase 5	Rattus norvegicus	35-59
15789756-0	2005	Formalin pretreatment attenuates tail-flick inhibition induced by beta-endorphin administered intracerebroventricularly or intrathecally in mice.	Formaldehyde	0-8	pro-opiomelanocortin-alpha	Mus musculus	66-80
15789756-12	2005	The s.c. formalin treatment increased the hypothalamic pro-opiomelanocortin (POMC) mRNA level at 2 h, but this returned to the basal level after 40 h. Our results suggest that the increase in the POMC mRNA level in the hypothalamus appears to be involved in the supraspinal or spinal beta-endorphin-induced antinociceptive tolerance in formalin-induced inflammatory pain.	Formaldehyde	9-17	pro-opiomelanocortin-alpha	Mus musculus	55-75
15789756-12	2005	The s.c. formalin treatment increased the hypothalamic pro-opiomelanocortin (POMC) mRNA level at 2 h, but this returned to the basal level after 40 h. Our results suggest that the increase in the POMC mRNA level in the hypothalamus appears to be involved in the supraspinal or spinal beta-endorphin-induced antinociceptive tolerance in formalin-induced inflammatory pain.	Formaldehyde	9-17	pro-opiomelanocortin-alpha	Mus musculus	77-81
15789756-12	2005	The s.c. formalin treatment increased the hypothalamic pro-opiomelanocortin (POMC) mRNA level at 2 h, but this returned to the basal level after 40 h. Our results suggest that the increase in the POMC mRNA level in the hypothalamus appears to be involved in the supraspinal or spinal beta-endorphin-induced antinociceptive tolerance in formalin-induced inflammatory pain.	Formaldehyde	9-17	pro-opiomelanocortin-alpha	Mus musculus	196-200
15789756-12	2005	The s.c. formalin treatment increased the hypothalamic pro-opiomelanocortin (POMC) mRNA level at 2 h, but this returned to the basal level after 40 h. Our results suggest that the increase in the POMC mRNA level in the hypothalamus appears to be involved in the supraspinal or spinal beta-endorphin-induced antinociceptive tolerance in formalin-induced inflammatory pain.	Formaldehyde	9-17	pro-opiomelanocortin-alpha	Mus musculus	284-298
15789756-12	2005	The s.c. formalin treatment increased the hypothalamic pro-opiomelanocortin (POMC) mRNA level at 2 h, but this returned to the basal level after 40 h. Our results suggest that the increase in the POMC mRNA level in the hypothalamus appears to be involved in the supraspinal or spinal beta-endorphin-induced antinociceptive tolerance in formalin-induced inflammatory pain.	Formaldehyde	336-344	pro-opiomelanocortin-alpha	Mus musculus	196-200
15606671-3	2005	METHODS: Gli1 transcript levels were measured by real-time quantitative reverse transcriptase polymerase chain reaction (RT-PCR) using RNA extracted from formalin-fixed, paraffin-embedded tissues of 68 cases of various skin tumors.	Formaldehyde	154-162	GLI family zinc finger 1	Homo sapiens	9-13
15684336-3	2005	Forty-three of 48 formalin-fixed paraffin-embedded heart specimens with various forms of systemic amyloidosis reacted immunohistochemically with anti-human apoAI antibody.	Formaldehyde	18-26	apolipoprotein A-I	Mus musculus	156-161
15730135-1	2005	The expression of mRNA encoding interleukin (IL)-10, IL-12p35 and IL-12p40 was studied, by reverse transcription-polymerase chain reaction and by in situ hybridization with a non-radioactive digoxigenin-labelled cDNA probe, in formalin-fixed, paraffin-wax-embedded lung tissue from pigs experimentally infected with Actinobacillus pleuropneumoniae.	Formaldehyde	227-235	IL10	Sus scrofa	32-51
15624917-3	2005	The common 1,2-anti-2,3-syn stereotriad found in each of three subunits, aldehyde 9 (C(1)-C(5)), ester 40 (C(9)-C(16)), and aldehyde 13 (C(17)-C(24)), was established via a boron-mediated aldol reaction of ethyl ketone 15 and formaldehyde, followed by hydroxyl-directed reduction to give 1,3-diol 14.	Formaldehyde	226-238	synemin	Homo sapiens	24-27
15572036-7	2005	Recombinant stabilin-2, but not recombinant stabilin-1, bound HA and the scavenger receptor ligands AGE-modified BSA, formaldehyde-treated BSA, and collagen N-terminal propeptides.	Formaldehyde	118-130	stabilin 2	Homo sapiens	12-22
15785205-5	2005	The binding of this MAb to ACE was greatly affected by conformational changes induced by adsorption on plastic, formalin fixation, and underglycosylation.	Formaldehyde	112-120	angiotensin I converting enzyme	Homo sapiens	27-30
15785205-7	2005	MAb 5C8 detected all the known expression sites of full-size ACE using formalin-fixed and paraffin-embedded human tissues.	Formaldehyde	71-79	angiotensin I converting enzyme	Homo sapiens	61-64
15681472-2	2005	We used DNA isolated from microdissected formalin-fixed, paraffin-embedded gastric tumors for mutation analysis of a region of the human gene for uracil-DNA glycosylase (UNG), encoding the UNG catalytic domain, and detected apparent base substitutions which, after further investigation, proved to be polymerase chain reaction (PCR) artifacts.	Formaldehyde	41-49	uracil DNA glycosylase	Homo sapiens	146-168
15681472-2	2005	We used DNA isolated from microdissected formalin-fixed, paraffin-embedded gastric tumors for mutation analysis of a region of the human gene for uracil-DNA glycosylase (UNG), encoding the UNG catalytic domain, and detected apparent base substitutions which, after further investigation, proved to be polymerase chain reaction (PCR) artifacts.	Formaldehyde	41-49	uracil DNA glycosylase	Homo sapiens	170-173
15681472-2	2005	We used DNA isolated from microdissected formalin-fixed, paraffin-embedded gastric tumors for mutation analysis of a region of the human gene for uracil-DNA glycosylase (UNG), encoding the UNG catalytic domain, and detected apparent base substitutions which, after further investigation, proved to be polymerase chain reaction (PCR) artifacts.	Formaldehyde	41-49	uracil DNA glycosylase	Homo sapiens	189-192
16040406-3	2005	We studied the breakpoints of the COL1A1 gene using formalin-fixed, paraffin-embedded tumour specimens from five patients with dermatofibrosarcoma protuberans (three reconfirmations and two new cases).	Formaldehyde	52-60	collagen type I alpha 1 chain	Homo sapiens	34-40
15659113-1	2005	AIM: To investigate effects of the cyclin-dependent kinase5 (Cdk5) inhibitor roscovitine on formalin-induced nociceptive responses in rats.	Formaldehyde	92-100	cyclin-dependent kinase 5	Rattus norvegicus	61-65
15659113-6	2005	Western blot analysis showed that phosphorylated DARPP-32 at Thr75 increased in concentration after formalin hyperalgesia, with this effect reduced by roscovitine administration.	Formaldehyde	100-108	protein phosphatase 1, regulatory (inhibitor) subunit 1B	Rattus norvegicus	49-57
15483043-6	2005	Immunohistochemical analysis on formalin-fixed and paraffin-embedded tissue reveals a spectrum of neuropathological changes, including actively and inactively demyelinating plaques in the white matter and optic nerve, vacuolation and cystic necrosis with CD8-positive T cells in the frontal lobe, axonal damage, and vacuolation of white matter.	Formaldehyde	32-40	CD8a molecule	Homo sapiens	255-258
16168125-5	2005	METHODS: We used immunohistochemistry to detect PDGFR-alpha overexpression on a series of 181 formalin-fixed paraffin-embedded invasive ductal breast carcinomas and in two breast cancer cell lines: MCF-7 and HS578T.	Formaldehyde	94-102	platelet derived growth factor receptor alpha	Homo sapiens	48-59
15987433-3	2005	METHODS: In this study c-erbB2 and topoisomerase IIalpha protein were evaluated by immunohistochemistry in formalin-fixed paraffin-embedded tissue from 225 samples of primary breast cancer, obtained between 1986 and 1998.	Formaldehyde	107-115	erb-b2 receptor tyrosine kinase 2	Homo sapiens	23-30
16035197-1	2005	OBJECTIVE: Methanol is metabolized by alcohol dehydrogenase to formaldehyde, and further to formic acid, which is responsible for the toxicity in methanol poisoning.	Formaldehyde	63-75	aldo-keto reductase family 1 member A1	Homo sapiens	38-59
16180654-0	2005	Intrathecal grafting of porcine chromaffin cells reduces formalin-evoked c-Fos expression in the rat spinal cord.	Formaldehyde	57-65	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	73-78
16180654-5	2005	To this end, the expression of c-Fos in response to intraplantar formalin injection was evaluated in animals following intrathecal grafting of 10(6) porcine or bovine chromaffin cells.	Formaldehyde	65-73	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	31-36
16180654-9	2005	The present study demonstrates that both xenogeneic porcine and bovine chromaffin cells transplanted into the spinal subarachnoid space of the rat can suppress formalin-evoked c-Fos expression equally, in parallel with suppression of nociceptive behaviors in the tonic phase of the test.	Formaldehyde	160-168	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	176-181
15671552-2	2005	EXPERIMENTAL DESIGN: Cyclin D3 immunoreactivity was evaluated in 223 formalin-fixed and paraffin-embedded samples of LSCC patients with a mean follow-up of 62.8 +/- 43.2 months.	Formaldehyde	69-77	cyclin D3	Homo sapiens	21-30
15650306-10	2005	Reduction of formalin-induced pain suggests direct analgesic BT effects possibly mediated by blockade of substance P, glutamate and calcitonin gene-related peptide.	Formaldehyde	13-21	tachykinin precursor 1	Homo sapiens	105-116
15875085-4	2005	The expression of Ki-67 and EGFR protein was visualized on formalin fixed, paraffin embedded sections using immunohistochemistry (IHC).	Formaldehyde	59-67	epidermal growth factor receptor	Homo sapiens	28-32
15470478-0	2005	Gene knockdown with intrathecal siRNA of NMDA receptor NR2B subunit reduces formalin-induced nociception in the rat.	Formaldehyde	76-84	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	55-59
15470478-6	2005	The results indicate that the use of siRNA targeting the NR2B subunit not only decreased the expression of NR2B mRNA and its associated protein, as demonstrated by real-time PCR and Western blotting, but also abolished formalin-induced pain behaviors in rat model.	Formaldehyde	219-227	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	57-61
15470478-6	2005	The results indicate that the use of siRNA targeting the NR2B subunit not only decreased the expression of NR2B mRNA and its associated protein, as demonstrated by real-time PCR and Western blotting, but also abolished formalin-induced pain behaviors in rat model.	Formaldehyde	219-227	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	107-111
15586235-4	2005	TMA analysis was applied on a distinct series of 36 formalin-fixed, paraffin-embedded DLCL samples and showed that TCL1A immunoexpression was correlated with either higher relapse (p=0.02) or lower 5-year overall survival (p=0.009) rates.	Formaldehyde	52-60	TCL1 family AKT coactivator A	Homo sapiens	115-120
15660650-7	2005	CONCLUSIONS: CD62L can be successfully applied in formalin-fixed tissue and exhibits enhanced specificity compared to CD7 in the evaluation of cutaneous T-cell infiltrates.	Formaldehyde	50-58	selectin L	Homo sapiens	13-18
15660650-8	2005	Both CD62L and CD7 in paraffin-embedded, formalin-fixed tissue are useful diagnostic adjuncts, especially in regard to the discrimination of lymphomatoid hypersensitivity reactions from true endogenous T-cell dyscrasia.	Formaldehyde	41-49	selectin L	Homo sapiens	5-10
15389254-3	2005	Immunohistochemical analysis for p63 was performed on formalin-fixed, paraffin-embedded archival tissue from 20 benign adnexal tumors, 10 malignant adnexal tumors and 14 adenocarcinomas metastatic to the skin.	Formaldehyde	54-62	tumor protein p63	Homo sapiens	33-36
15691066-0	2005	Role of cyclooxygenase-2 in lipopolysaccharide-induced hyperalgesia in formalin test.	Formaldehyde	71-79	prostaglandin-endoperoxide synthase 2	Mus musculus	8-24
15691066-10	2005	These results suggest that induction of COX-2 by proinflammatory mediators and subsequent release of prostaglandins could be responsible for LPS enhancement of formalin-induced nocifensive behaviour and supports an important role of COX-2 in LPS-induced hyperalgesia in the formalin test.	Formaldehyde	160-168	cytochrome c oxidase II, mitochondrial	Mus musculus	40-45
15691066-10	2005	These results suggest that induction of COX-2 by proinflammatory mediators and subsequent release of prostaglandins could be responsible for LPS enhancement of formalin-induced nocifensive behaviour and supports an important role of COX-2 in LPS-induced hyperalgesia in the formalin test.	Formaldehyde	274-282	cytochrome c oxidase II, mitochondrial	Mus musculus	40-45
15949135-5	2005	We found that purified L. pneumophila LPS as well as L. pneumophila either viable or formalin-killed are able to activate BMDCs from TLR4-deficient C3H/HeJ mice but fail to activate BMDCs from TLR2-knockout mice.	Formaldehyde	85-93	toll-like receptor 4	Mus musculus	133-137
15953687-0	2005	Periaqueductal grey CB1 cannabinoid and metabotropic glutamate subtype 5 receptors modulate changes in rostral ventromedial medulla neuronal activities induced by subcutaneous formalin in the rat.	Formaldehyde	176-184	cannabinoid receptor 1	Rattus norvegicus	20-23
15664703-1	2005	The role of peripheral serotonin (5HT) 2A and 5HT1A receptors on the orofacial nocifensive behavioral activities evoked by the injection of formalin into the masseter muscle was evaluated in the rats with persistent temporomandibular joint (TMJ) inflammation evoked by Complete Freund"s Adjuvant (CFA).	Formaldehyde	140-148	5-hydroxytryptamine receptor 1A	Rattus norvegicus	23-61
15893631-9	2005	Galanin overexpressing mice showed an attenuated plasma extravasation, an increased pain response in the formalin test, and changes in muscle physiology, but did not differ from wild type mice in sudomotor function.	Formaldehyde	105-113	galanin and GMAP prepropeptide	Mus musculus	0-7
15807307-3	2005	We investigated formalin-fixed and paraffin-embedded tissue specimens obtained from 83 selected patients (55 with preinvasive neoplastic lesions and 28 with invasive squamous cervical carcinoma) for the expression of hMSH2 and hMLH1 at the immunohistochemical level.	Formaldehyde	16-24	mutS homolog 2	Homo sapiens	217-222
15583802-4	2005	Immunostaining with an MIF specific antibody was performed in formalin-fixed, paraffin-embedded specimens.	Formaldehyde	62-70	macrophage migration inhibitory factor	Homo sapiens	23-26
17822280-3	2005	In this study, a new series of butyric acid and formaldehyde-releasing drugs related to AN9 (pivaloyloxymethyl butyrate) was assessed for their ability to facilitate Adriamycin-DNA adduct formation in Adriamycin-sensitive and -resistant cell lines (HL60 and HL60/MX2; MES-SA and MES-SA/Dx5).	Formaldehyde	48-60	MX dynamin like GTPase 2	Homo sapiens	263-266
15623599-8	2004	This is the first localization of all of the VIP/PACAP receptor subtypes in human formalin-fixed, paraffin-embedded tissues.	Formaldehyde	82-90	vasoactive intestinal peptide	Homo sapiens	45-48
16308102-4	2005	Here, we describe a double-immunostaining strategy for formalin-fixed, paraffin-embedded tissues that aims at evaluating the distribution of Prox-1 and CD 31 - a cytoplasmic pan-endothelial marker - in a series of 28 mucousae, cutaneous and soft tissue vascular lesions and tumors, including hemangiomas, lymphangiomas, lymphangiectasia, and Kaposi"s sarcomas.	Formaldehyde	55-63	prospero homeobox 1	Homo sapiens	141-147
16308102-4	2005	Here, we describe a double-immunostaining strategy for formalin-fixed, paraffin-embedded tissues that aims at evaluating the distribution of Prox-1 and CD 31 - a cytoplasmic pan-endothelial marker - in a series of 28 mucousae, cutaneous and soft tissue vascular lesions and tumors, including hemangiomas, lymphangiomas, lymphangiectasia, and Kaposi"s sarcomas.	Formaldehyde	55-63	platelet and endothelial cell adhesion molecule 1	Homo sapiens	152-157
15805074-4	2005	In the present study we demonstrated that in rat formalin-fixed, paraffin-embedded ovary sections follicles of all degrees of maturity can be visualized by the use of antibody directed against proliferating cell nuclear antigen (PCNA).	Formaldehyde	49-57	proliferating cell nuclear antigen	Rattus norvegicus	193-227
15805074-4	2005	In the present study we demonstrated that in rat formalin-fixed, paraffin-embedded ovary sections follicles of all degrees of maturity can be visualized by the use of antibody directed against proliferating cell nuclear antigen (PCNA).	Formaldehyde	49-57	proliferating cell nuclear antigen	Rattus norvegicus	229-233
15588086-0	2004	Antiestrogen binding site and estrogen receptor mediate uptake and distribution of 4-hydroxytamoxifen-targeted doxorubicin-formaldehyde conjugate in breast cancer cells.	Formaldehyde	123-135	estrogen receptor 1	Homo sapiens	30-47
15588086-3	2004	We have recently reported the design, synthesis, and preliminary evaluation of a doxorubicin-formaldehyde conjugate targeted, via 4-hydroxytamoxifen, to the estrogen receptor (ER) and antiestrogen binding site (AEBS), which are commonly present in breast cancer cells.	Formaldehyde	93-105	estrogen receptor 1	Homo sapiens	157-174
15588086-3	2004	We have recently reported the design, synthesis, and preliminary evaluation of a doxorubicin-formaldehyde conjugate targeted, via 4-hydroxytamoxifen, to the estrogen receptor (ER) and antiestrogen binding site (AEBS), which are commonly present in breast cancer cells.	Formaldehyde	93-105	estrogen receptor 1	Homo sapiens	176-178
15588086-4	2004	The lead targeted doxorubicin-formaldehyde conjugate, called DOX-TEG-TAM, was found to possess superior cell growth inhibition characteristics relative to clinical doxorubicin and an untargeted control conjugate, especially in ER-negative, multidrug resistant MCF-7/Adr cells.	Formaldehyde	30-42	estrogen receptor 1	Homo sapiens	227-229
15588086-6	2004	Fluorescence microscopy of an ER-negative, AEBS-positive cell line as a function of time showed initial DOX-TEG-TAM localization in cytosol, in contrast to initial DOX and untargeted doxorubicin-formaldehyde conjugate localization in the nucleus.	Formaldehyde	195-207	estrogen receptor 1	Homo sapiens	30-32
15588086-12	2004	The data support the hypothesis that uptake of 4-hydroxytamoxifen targeted doxorubicin-formaldehyde conjugate is mediated by both the antiestrogen binding site and estrogen receptor.	Formaldehyde	87-99	estrogen receptor 1	Homo sapiens	164-181
15976947-6	2005	Immunohistochemical detection of MMP-9 expression was done using a wet autoclave antigen retrieval method on sections from formalin-fixed and paraffin-embedded lung tissue.	Formaldehyde	123-131	matrix metallopeptidase 9	Homo sapiens	33-38
15644253-2	2005	The biodegradation of formaldehyde (260 mgl(-1)) as single carbon source and at phenol concentrations ranging from 30 to 580 mgl(-1) was investigated in batch assays, obtaining an initial biodegradation rate around 0.5g CH(2)OgVSS(-1)d(-1).	Formaldehyde	22-34	LLGL scribble cell polarity complex component 1	Homo sapiens	40-46
15644253-2	2005	The biodegradation of formaldehyde (260 mgl(-1)) as single carbon source and at phenol concentrations ranging from 30 to 580 mgl(-1) was investigated in batch assays, obtaining an initial biodegradation rate around 0.5g CH(2)OgVSS(-1)d(-1).	Formaldehyde	22-34	LLGL scribble cell polarity complex component 1	Homo sapiens	125-131
15623619-2	2004	EXPERIMENTAL DESIGN: HIF-1alpha expression was examined in formalin-fixed tumor biopsies using a semiquantitative scoring system and correlated with measurements of hypoxia obtained using oxygen electrodes, pimonidazole staining, and carbonic anhydrase 9.	Formaldehyde	59-67	hypoxia inducible factor 1 subunit alpha	Homo sapiens	21-31
15623623-2	2004	EXPERIMENTAL DESIGN: Immunohistochemical staining for IGF-1R was done on formalin-fixed, paraffin-embedded specimens from 161 patients with curatively resected Dukes" C CRC and at least 5-year follow-up periods.	Formaldehyde	73-81	insulin like growth factor 1 receptor	Homo sapiens	54-60
15623599-8	2004	This is the first localization of all of the VIP/PACAP receptor subtypes in human formalin-fixed, paraffin-embedded tissues.	Formaldehyde	82-90	adenylate cyclase activating polypeptide 1	Homo sapiens	49-54
15548813-6	2004	Flow cytometry was used to assess c-myc expression in formalin fixed material from the primary specimens.	Formaldehyde	54-62	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	34-39
15536330-3	2004	Formalin-fixed, paraffin-embedded tissue was immunostained with antibodies to p53, p27, phospho-AKT, and bcl-2 using the avidin-biotin-peroxidase method and tissue microarray technique.	Formaldehyde	0-8	BCL2 apoptosis regulator	Homo sapiens	105-110
15815077-5	2004	Oxidative bio-activation of N-nitrosamines by the microsomal CYP isoforms was measured as formaldehyde formation.	Formaldehyde	90-102	cytochrome P-450	Oryctolagus cuniculus	61-64
15459092-0	2004	Additional data for oligonucleotide arrays of the p53 gene in DNA from formalin-fixed, paraffin-embedded tissue.	Formaldehyde	71-79	tumor protein p53	Homo sapiens	50-53
15606364-2	2004	Chromogenic in situ hybridization (CISH), in which the DNA probe is detected with an immunohistochemistry (IHC)-like peroxidase reaction, has been recently developed for the assessment of HER-2/neu status in formalin-fixed breast cancer specimens.	Formaldehyde	208-216	erb-b2 receptor tyrosine kinase 2	Homo sapiens	188-197
15627061-2	2004	METHODS: S6K1/2 expression and phosphorylated ribosomal S6 protein (phS6) content have been detected in formalin fixed, paraffin embedded sections of 50 human endometrial adenocarcinomas with different grade of differentiation and in 13 normal endometrial tissues using immunohistochemical approach with following semiquantitative analysis.	Formaldehyde	104-112	ribosomal protein S6 kinase B1	Homo sapiens	9-15
15619214-3	2004	IGF-1R expression was evaluated in formalin-fixed, paraffin-embedded tissue of 210 primary breast cancer patients by using anti-IGF-1R antibody.	Formaldehyde	35-43	insulin like growth factor 1 receptor	Homo sapiens	0-6
15627062-2	2004	METHODS: The expression level and localization of S6K have been detected in formalin fixed, paraffin embedded sections of normal human breast tissues, adenomas and adenocarcinomas with different grade of differentiation.	Formaldehyde	76-84	ribosomal protein S6 kinase B2	Homo sapiens	50-53
15654138-1	2004	BACKGROUND &amp; OBJECTIVES: The spinal expression of the c-Fos immediate early gene in response to formalin pain of the hind paw of rat was used as a marker of neuronal activity.	Formaldehyde	100-108	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	58-63
15513895-3	2004	An increase in formaldehyde generation was subsequently shown following incubation of cocaine with the S9 fractions prepared from SKF 525-A-treated mice, indicating the possibility of cytochrome P-450 (CYP) induction.	Formaldehyde	15-27	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	184-200
15513895-3	2004	An increase in formaldehyde generation was subsequently shown following incubation of cocaine with the S9 fractions prepared from SKF 525-A-treated mice, indicating the possibility of cytochrome P-450 (CYP) induction.	Formaldehyde	15-27	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	202-205
15619426-3	2004	Heat, formalin or protease treatment of F. nucleatum cells attenuated the IL-8 mRNA up-regulation.	Formaldehyde	6-14	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
15389827-10	2004	We conclude that the hindpaw injection of formalin leads to enhanced early and late expression of many genes in spinal cord dorsal horn tissue, and that this enhancement of expression relies to a degree on the presence of HO-2.	Formaldehyde	42-50	heme oxygenase 2	Mus musculus	222-226
15518813-0	2004	Baculovirus proteins IE-1, LEF-3, and P143 interact with DNA in vivo: a formaldehyde cross-linking study.	Formaldehyde	72-84	early gene transactivator	Autographa californica nucleopolyhedrovirus	21-25
15518813-0	2004	Baculovirus proteins IE-1, LEF-3, and P143 interact with DNA in vivo: a formaldehyde cross-linking study.	Formaldehyde	72-84	late expression factor 3	Autographa californica nucleopolyhedrovirus	27-32
15518813-0	2004	Baculovirus proteins IE-1, LEF-3, and P143 interact with DNA in vivo: a formaldehyde cross-linking study.	Formaldehyde	72-84	helicase	Autographa californica nucleopolyhedrovirus	38-42
15489007-0	2004	Grafts of immortalized chromaffin cells bio-engineered to improve met-enkephalin release also reduce formalin-evoked c-fos expression in rat spinal cord.	Formaldehyde	101-109	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	117-122
15489007-5	2004	In the formalin hindpaw-injection model, 15 days after subarachnoid transplant of cells, grafts of met-enkephalin and pro-enkephalin cells significantly reduced the number of formalin-evoked c-fos immunoreactive spinal neurons in the spinal cord, compared to grafts of vector-alone chromaffin cells.	Formaldehyde	7-15	proenkephalin	Rattus norvegicus	118-132
15489007-5	2004	In the formalin hindpaw-injection model, 15 days after subarachnoid transplant of cells, grafts of met-enkephalin and pro-enkephalin cells significantly reduced the number of formalin-evoked c-fos immunoreactive spinal neurons in the spinal cord, compared to grafts of vector-alone chromaffin cells.	Formaldehyde	7-15	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	191-196
15496471-8	2004	In vivo binding of ChREBP to ACC, FAS, and LPK gene promoters in intact liver nuclei from rats fed a high-carbohydrate diet was demonstrated by using a formaldehyde crosslinking and chromatin immunoprecipitation procedure.	Formaldehyde	152-164	MLX interacting protein-like	Rattus norvegicus	19-25
15489007-5	2004	In the formalin hindpaw-injection model, 15 days after subarachnoid transplant of cells, grafts of met-enkephalin and pro-enkephalin cells significantly reduced the number of formalin-evoked c-fos immunoreactive spinal neurons in the spinal cord, compared to grafts of vector-alone chromaffin cells.	Formaldehyde	175-183	proenkephalin	Rattus norvegicus	118-132
15496471-8	2004	In vivo binding of ChREBP to ACC, FAS, and LPK gene promoters in intact liver nuclei from rats fed a high-carbohydrate diet was demonstrated by using a formaldehyde crosslinking and chromatin immunoprecipitation procedure.	Formaldehyde	152-164	fatty acid synthase	Mus musculus	34-37
15496471-8	2004	In vivo binding of ChREBP to ACC, FAS, and LPK gene promoters in intact liver nuclei from rats fed a high-carbohydrate diet was demonstrated by using a formaldehyde crosslinking and chromatin immunoprecipitation procedure.	Formaldehyde	152-164	pyruvate kinase L/R	Rattus norvegicus	43-46
15489007-5	2004	In the formalin hindpaw-injection model, 15 days after subarachnoid transplant of cells, grafts of met-enkephalin and pro-enkephalin cells significantly reduced the number of formalin-evoked c-fos immunoreactive spinal neurons in the spinal cord, compared to grafts of vector-alone chromaffin cells.	Formaldehyde	175-183	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	191-196
15838353-0	2004	Inhibitory effects of a selective endothelin-A receptor antagonist YM598 on endothelin-1-induced potentiation of nociception in formalin-induced and prostate cancer-induced pain models in mice.	Formaldehyde	128-136	endothelin 1	Mus musculus	76-88
15509168-9	2004	The results indicate that doxorubicin-formaldehyde conjugate bonded to cyanonilutamide via a cleavable linear tether enters PC3 cells, resides in cytosol, binds to the AR if present, and ultimately releases doxorubicin or a doxorubicin derivative to the nucleus.	Formaldehyde	38-50	chromobox 8	Homo sapiens	124-127
15509168-9	2004	The results indicate that doxorubicin-formaldehyde conjugate bonded to cyanonilutamide via a cleavable linear tether enters PC3 cells, resides in cytosol, binds to the AR if present, and ultimately releases doxorubicin or a doxorubicin derivative to the nucleus.	Formaldehyde	38-50	androgen receptor	Homo sapiens	168-170
15492566-7	2004	Formalin-fixed paraffin-embedded tissues were immunostained with polyclonal anti-DPD antibody.	Formaldehyde	0-8	dihydropyrimidine dehydrogenase	Homo sapiens	81-84
15500653-3	2004	METHODS: Galectin-3 protein expression was assessed by immunohistochemistry in formalin-fixed thyroid tissues from 124 patients with histological diagnoses of papillary carcinoma (n = 38), follicular carcinoma (n = 19), follicular adenoma (n = 32) and dominant nodules of multinodular goitre (n = 35).	Formaldehyde	79-87	galectin 3	Homo sapiens	9-19
15509168-0	2004	Studies of targeting and intracellular trafficking of an anti-androgen doxorubicin-formaldehyde conjugate in PC-3 prostate cancer cells bearing androgen receptor-GFP chimera.	Formaldehyde	83-95	androgen receptor	Homo sapiens	144-161
15509168-1	2004	The synthesis of a doxorubicin-formaldehyde conjugate bound to the nonsteroidal anti-androgen cyanonilutamide, via a cleavable tether, and binding of the construct to cell free androgen receptor (AR) as a function of tether design were previously reported.	Formaldehyde	31-43	androgen receptor	Homo sapiens	177-194
15509168-1	2004	The synthesis of a doxorubicin-formaldehyde conjugate bound to the nonsteroidal anti-androgen cyanonilutamide, via a cleavable tether, and binding of the construct to cell free androgen receptor (AR) as a function of tether design were previously reported.	Formaldehyde	31-43	androgen receptor	Homo sapiens	196-198
15534111-9	2004	When formalin-fixed specimens from 52 patients with ESCC were stained immunohistochemically, it was found that Mina53 was highly expressed in 83% of specimens.	Formaldehyde	5-13	ribosomal oxygenase 2	Homo sapiens	111-117
15501291-5	2004	Flow cytometric analysis revealed that FITC-TMVA bound to human formalin-fixed platelets in a saturable manner, and its binding was specifically blocked by HIP1 in a dose-dependent manner.	Formaldehyde	64-72	huntingtin interacting protein 1	Homo sapiens	156-160
15505341-3	2004	To prove this, we needed to develop an assay to quantify ODC levels in formalin-fixed tumor tissues, which would enable a retrospective study of tumor biopsy specimens from the landmark clinical trial.	Formaldehyde	71-79	ornithine decarboxylase 1	Homo sapiens	57-60
15505341-10	2004	We conclude that we can measure levels of ODC in formalin-fixed tumor tissue using an antibody to ODC coupled to Alexa 647 dye, and this will enable us to conduct a future study to correlate survival of patients with gliomas of different histologies treated with DFMO to tumor ODC levels.	Formaldehyde	49-57	ornithine decarboxylase 1	Homo sapiens	42-45
15505341-10	2004	We conclude that we can measure levels of ODC in formalin-fixed tumor tissue using an antibody to ODC coupled to Alexa 647 dye, and this will enable us to conduct a future study to correlate survival of patients with gliomas of different histologies treated with DFMO to tumor ODC levels.	Formaldehyde	49-57	ornithine decarboxylase 1	Homo sapiens	98-101
15505341-10	2004	We conclude that we can measure levels of ODC in formalin-fixed tumor tissue using an antibody to ODC coupled to Alexa 647 dye, and this will enable us to conduct a future study to correlate survival of patients with gliomas of different histologies treated with DFMO to tumor ODC levels.	Formaldehyde	49-57	ornithine decarboxylase 1	Homo sapiens	98-101
15586569-2	2004	The immunohistochemical pattern of E-cad expression was evaluated in formalin-fixed and paraffin-embedded sections of 6 normal mammary glands, 3 dysplasias, 12 benign tumors (8 benign mixed tumors, 4 adenomas), and 60 malignant tumors (12 stage 0, 29 stage I, 19 stage II) of the canine mammary gland.	Formaldehyde	69-77	cadherin 1	Canis lupus familiaris	35-40
15565546-26	2004	CONCLUSIONS: Using our different sets of exon specific primer pairs, it was possible to detect 4 different breakpoints of ews/fli1 fusion transcripts and the ews/erg fusion by RT-PCR in RNA isolates from formalin-fixed, paraffin-embedded Ewing"s tumor tissue.	Formaldehyde	204-212	EWS RNA binding protein 1	Homo sapiens	122-125
15464832-9	2004	Taken together, these results suggest that COX-2 plays an important role both in the central and in the peripheral nerve sensitization following formalin administration in rat paws.	Formaldehyde	145-153	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	43-48
15448640-3	2004	Using immunoprecipitation of in vivo formaldehyde-fixed chromatin in phenotypically diverse cultured cell lines, we have mapped PRC1 components, the histone methyl transferase (HMT) Enhancer of zeste (E(z)) and histone H3 modifications in active and inactive PcG-controlled regions.	Formaldehyde	37-49	Suppressor of variegation 3-9	Drosophila melanogaster	177-180
15476746-5	2004	The results of the present study indicate that spinal 5-HT(1B,) 5-HT(2C,) 5-HT3 and 5-HT4 receptors, but not the 5-HT(1D) receptor, mediate antinociception produced by 5-HT in the formalin test.	Formaldehyde	180-188	5-hydroxytryptamine receptor 1B	Rattus norvegicus	54-61
15738866-2	2004	Immunostaining of synaptophysin after formalin fixation may be used to identify hyperplasia of nerve fibers and rarefaction of neuromuscular junctions in Hirschsprung"s disease.	Formaldehyde	38-46	synaptophysin	Homo sapiens	18-31
15369794-2	2004	Hot plate and formalin tests revealed that reflexes to heat and pain were significantly decreased in NMU KO mice.	Formaldehyde	14-22	neuromedin U	Mus musculus	101-104
15369794-5	2004	NMU mRNA expression increased in the spinal cord, but not in the hypothalamus, 2 and 4 h after formalin injection.	Formaldehyde	95-103	neuromedin U	Mus musculus	0-3
15367415-2	2004	PATIENTS AND METHODS: The protein expression of E-cadherin was immunohistochemically evaluated in formalin-fixed, paraffin-embedded samples in 104 patients with primary ovarian carcinomas.	Formaldehyde	98-106	cadherin 1	Homo sapiens	48-58
15764285-10	2004	On the other hand, after 12 h formalin fixation, osteocalcin labeling was comparable to HistoChoice.	Formaldehyde	30-38	bone gamma-carboxyglutamate protein 2	Mus musculus	49-60
15486895-5	2004	Expression of CXCR4 (12g5 antibody) was evaluated on formalin-fixed paraffin-embedded tumor tissues using standard immunohistochemical techniques.	Formaldehyde	53-61	C-X-C motif chemokine receptor 4	Homo sapiens	14-19
15466022-7	2004	The operon was shown to be induced by formaldehyde, and the genes have been renamed frmR, frmA, and frmB, respectively.	Formaldehyde	38-50	alcohol dehydrogenase class-III	Escherichia coli	90-94
15959550-6	2004	Formalin-fixed paraffin-embedded tissues were stained with MMP-2 immunostaining, using improved streptavidin-biotin amplified system.	Formaldehyde	0-8	matrix metallopeptidase 2	Homo sapiens	59-64
15306260-0	2004	Increased substance P and tumor necrosis factor-alpha level in the paws following formalin injection in rat tail.	Formaldehyde	82-90	tumor necrosis factor	Rattus norvegicus	26-53
15568401-3	2004	Formalin-fixed, paraffin-embedded tissue was stained for nm23-H1.	Formaldehyde	0-8	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	57-64
15568402-2	2004	STUDY DESIGN: Polymerase chain reaction (PCR) was used to amplify DNA sequences of the viruses and PCR-single-strand conformation polymorphism analysis to screen for p53 gene mutations in exons 5-8 from formalin-fixed, paraffin-embedded blocks including 10 undifferentiated vulvar intraepithelial neoplasia (VIN) specimens.	Formaldehyde	203-211	tumor protein p53	Homo sapiens	166-169
15331166-0	2004	Blockade of peripheral 5HT3 receptor attenuates the formalin-induced nocifensive behavior in persistent temporomandibular joint inflammation of rat.	Formaldehyde	52-60	5-hydroxytryptamine receptor 3A	Rattus norvegicus	23-36
15331166-4	2004	Systemic administration of tropisetron, 5HT3 receptor antagonist, reduced the nocifensive behavioral activities in the late phase of orofacial formalin test in CFA group, but not in non-CFA group.	Formaldehyde	143-151	5-hydroxytryptamine receptor 3A	Rattus norvegicus	40-53
15355919-3	2004	EXPERIMENTAL DESIGN: COX-2 expression in normal colonic mucosa (n = 50), hyperplastic polyps (n = 43), sporadic adenomas (n = 67), and invasive colonic adenocarcinoma (n = 39) was studied in formalin-fixed and paraffin-embedded tissue sections from endoscopy biopsy and colonic resection specimens.	Formaldehyde	191-199	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
15327822-0	2004	Estrogen and mu-opioid receptor antagonists counteract the 17 beta-estradiol-induced licking increase and interferon-gamma reduction occurring during the formalin test in male rats.	Formaldehyde	154-162	interferon gamma	Rattus norvegicus	106-122
15128865-0	2004	Protein cross-linkage induced by formaldehyde derived from semicarbazide-sensitive amine oxidase-mediated deamination of methylamine.	Formaldehyde	33-45	amine oxidase copper containing 2	Homo sapiens	59-96
15128865-1	2004	Semicarbazide-sensitive amine oxidase (SSAO) catalyzes the conversion of methylamine to formaldehyde.	Formaldehyde	88-100	amine oxidase copper containing 2	Homo sapiens	0-37
15128865-1	2004	Semicarbazide-sensitive amine oxidase (SSAO) catalyzes the conversion of methylamine to formaldehyde.	Formaldehyde	88-100	amine oxidase copper containing 2	Homo sapiens	39-43
15128865-7	2004	We further demonstrate that incubation of methylamine in the presence of SSAO-rich tissues, e.g., human brain meninges, results in formaldehyde-protein cross-linkage of particulate bound proteins as well as of soluble proteins.	Formaldehyde	131-143	amine oxidase copper containing 2	Homo sapiens	73-77
15128865-9	2004	Our data support the hypothesis that the SSAO-induced production of formaldehyde may be involved in the alteration of protein structure, which may subsequently cause protein deposition associated with chronic pathological disorders.	Formaldehyde	68-80	amine oxidase copper containing 2	Homo sapiens	41-45
15363040-10	2004	Expression of API2-MALT1 fusion transcripts was detected by reverse transcription-polymerase chain reaction analysis using formalin-fixed, paraffin-embedded tissue.	Formaldehyde	123-131	baculoviral IAP repeat containing 3	Homo sapiens	14-18
15327822-10	2004	Indeed, formalin injection per se decreased IFN-gamma production; estradiol had no effect on sham-injected animals but strongly reduce the decrease of IFN-gamma production in formalin-injected animals.	Formaldehyde	8-16	interferon gamma	Rattus norvegicus	44-53
15363040-10	2004	Expression of API2-MALT1 fusion transcripts was detected by reverse transcription-polymerase chain reaction analysis using formalin-fixed, paraffin-embedded tissue.	Formaldehyde	123-131	MALT1 paracaspase	Homo sapiens	19-24
15327822-10	2004	Indeed, formalin injection per se decreased IFN-gamma production; estradiol had no effect on sham-injected animals but strongly reduce the decrease of IFN-gamma production in formalin-injected animals.	Formaldehyde	175-183	interferon gamma	Rattus norvegicus	151-160
15302208-2	2004	Unfortunately however, exaggerated CD4 T cell responses can cause significant immune-mediated disease as was observed during RSV infections in children previously vaccinated with a formalin-inactivated virus in the 1960s.	Formaldehyde	181-189	CD4 molecule	Homo sapiens	35-38
15388298-3	2004	Using antisense oligodeoxynucleotides, we tested the role of the NR1 subunit of the NMDA receptor in the nociception and expression of the immediate early gene c-fos following formalin-induced pain.	Formaldehyde	176-184	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	65-68
15388298-3	2004	Using antisense oligodeoxynucleotides, we tested the role of the NR1 subunit of the NMDA receptor in the nociception and expression of the immediate early gene c-fos following formalin-induced pain.	Formaldehyde	176-184	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	160-165
15388298-9	2004	Similarly, the antisense oligodeoxynucleotide virtually abolished formalin-induced expression of c-Fos-like immunoreactivity (Fos-IR) in the spinal cord dorsal horn ipsilateral to injection.	Formaldehyde	66-74	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	97-102
15388298-11	2004	We conclude that an NR1 antisense oligodeoxynucleotide inhibits both nociceptive behavior and c-fos expression following formalin injection in rats, demonstrating that NR1 plays an important role in the development of noxious stimulation induced c-fos expression in this model.	Formaldehyde	121-129	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	20-23
15388298-11	2004	We conclude that an NR1 antisense oligodeoxynucleotide inhibits both nociceptive behavior and c-fos expression following formalin injection in rats, demonstrating that NR1 plays an important role in the development of noxious stimulation induced c-fos expression in this model.	Formaldehyde	121-129	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	94-99
15388298-11	2004	We conclude that an NR1 antisense oligodeoxynucleotide inhibits both nociceptive behavior and c-fos expression following formalin injection in rats, demonstrating that NR1 plays an important role in the development of noxious stimulation induced c-fos expression in this model.	Formaldehyde	121-129	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	168-171
15388298-11	2004	We conclude that an NR1 antisense oligodeoxynucleotide inhibits both nociceptive behavior and c-fos expression following formalin injection in rats, demonstrating that NR1 plays an important role in the development of noxious stimulation induced c-fos expression in this model.	Formaldehyde	121-129	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	246-251
15388298-0	2004	NMDA-R1 antisense oligodeoxynucleotides modify formalin-induced nociception and spinal c-Fos expression in rat spinal cord.	Formaldehyde	47-55	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	0-7
15301767-6	2004	MIB-1 detected in formalin-fixed material with pre-treatment with antigen retrieval solution appeared to be a reliable marker of proliferation in feline mammary tumours, but further studies are needed to investigate the value of this proliferation marker in predicting clinical outcome and/or as a prognostic factor in feline mammary lesions.	Formaldehyde	18-26	MIB E3 ubiquitin protein ligase 1	Felis catus	0-5
15197780-2	2004	Expression of c-kit was examined immunohistochemically in formalin-fixed, paraffin-embedded tissue sections.	Formaldehyde	58-66	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	14-19
15308291-4	2004	When challenged with intraplantar formalin on P11, rats exposed to acute or chronic EtOH had enhanced phase II pain behaviors.	Formaldehyde	34-42	S100 calcium binding protein A10	Rattus norvegicus	46-49
15279632-6	2004	Akt expression analysis was performed by immunohistochemistry on formalin-fixed histological sections using an anti-phosphorylated-Akt (Ser473) antibody.	Formaldehyde	65-73	AKT serine/threonine kinase 1	Homo sapiens	0-3
15551757-2	2004	We immunohistochemically demonstrated the expression and intracellular localization of FKHRL1 in human breast tumors by the novel anti-FKHRL1 antibody which is available for formalin-fixed paraffin-embedded specimens.	Formaldehyde	174-182	forkhead box O3	Homo sapiens	87-93
15551757-2	2004	We immunohistochemically demonstrated the expression and intracellular localization of FKHRL1 in human breast tumors by the novel anti-FKHRL1 antibody which is available for formalin-fixed paraffin-embedded specimens.	Formaldehyde	174-182	forkhead box O3	Homo sapiens	135-141
15252319-11	2004	Electron microscopic studies performed on the paraffin-embedded renal tumor and formalin-fixed lung tumor revealed the typical rhomboid crystals of proto-renin.	Formaldehyde	80-88	renin	Homo sapiens	154-159
15322678-4	2004	By using immunocytochemical techniques, the formalin-induced Fos-LI neurons in the lumbar dorsal horn were calculated 1 h after formalin injection.	Formaldehyde	44-52	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	61-64
15322678-4	2004	By using immunocytochemical techniques, the formalin-induced Fos-LI neurons in the lumbar dorsal horn were calculated 1 h after formalin injection.	Formaldehyde	128-136	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	61-64
15245814-3	2004	METHODS: The immunohistochemical expression of HIF-1 alpha was evaluated in 93 formalin-fixed paraffin-embedded primary transitional cell carcinoma tissue samples.	Formaldehyde	79-87	hypoxia inducible factor 1 subunit alpha	Homo sapiens	47-58
15363317-2	2004	METHODS: One-step reverse transcriptase-polymerase chain reaction (RT-PCR) was employed to detect a characteristic EWS-FLI1/ERG fusion transcript in 25 cases of ES/pPNET and 15 cases of other small round cell tumors (including 8 cases of rhabdomyosarcoma, 4 cases of synovial sarcoma, 2 cases of neuroblastoma and 1 case of lymphoma) using formalin-fixed and paraffin-embedded tissues.	Formaldehyde	340-348	EWS RNA binding protein 1	Homo sapiens	115-118
15280411-7	2004	CRBP1 expression was assessed by immunohistochemistry on formalin fixed, paraffin wax embedded tissue.	Formaldehyde	57-65	retinol binding protein 1	Homo sapiens	0-5
15284539-5	2004	METHODS: MUC4 and ErbB2 receptor expression was localized by immunohistochemical studies using archival formalin-fixed and paraffin-embedded tissue.	Formaldehyde	104-112	mucin 4, cell surface associated	Homo sapiens	9-13
15284539-5	2004	METHODS: MUC4 and ErbB2 receptor expression was localized by immunohistochemical studies using archival formalin-fixed and paraffin-embedded tissue.	Formaldehyde	104-112	erb-b2 receptor tyrosine kinase 2	Homo sapiens	18-23
15363317-2	2004	METHODS: One-step reverse transcriptase-polymerase chain reaction (RT-PCR) was employed to detect a characteristic EWS-FLI1/ERG fusion transcript in 25 cases of ES/pPNET and 15 cases of other small round cell tumors (including 8 cases of rhabdomyosarcoma, 4 cases of synovial sarcoma, 2 cases of neuroblastoma and 1 case of lymphoma) using formalin-fixed and paraffin-embedded tissues.	Formaldehyde	340-348	ETS transcription factor ERG	Homo sapiens	124-127
15162220-4	2004	Double Mannich reaction of 4 with ethylamine and formaldehyde produced bicyclic amine 5 The C-9 ketone of bicyclic amine 5 was selectively reduced to form bicyclic alcohols 6 and 7 which were subsequently allylated to form dienes 8 and 9.	Formaldehyde	49-61	complement C9	Homo sapiens	92-95
21192429-0	2004	[Changes of COX-2 expression in the dorsal horn of the spinal cord during formalin-induced inflammatory pain and hyperalgesia in rats].	Formaldehyde	74-82	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	12-17
21192429-1	2004	AIM: To observe the changes of cyclooxygenase-2 (COX-2) expression and especially the time course of the changes in dorsal horn of the spinal cord during formalin-induced inflammatory pain and hyperalgesia in rats.	Formaldehyde	154-162	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	49-54
21192429-2	2004	METHODS: COX-2 immunohistochemistry staining was used in rat formalin pain model.	Formaldehyde	61-69	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	9-14
21192429-3	2004	RESULTS: Compared with control group the number and immunostaining density of COX-2 immunoreactive cells in the laminae I-VI of the dorsal horn of the spinal cord increased significantly 4 h, 1 d and 3 d after formalin injection (P &lt; 0.05).	Formaldehyde	210-218	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	78-83
21192429-5	2004	CONCLUSION: COX-2 in the dorsal horn of the spinal cord is involved in the formalin-induced inflammatory pain and hyperalgesia.	Formaldehyde	75-83	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	12-17
15196973-0	2004	Effect of prolonged exposure to low concentrations of formaldehyde on the corticotropin releasing hormone neurons in the hypothalamus and adrenocorticotropic hormone cells in the pituitary gland in female mice.	Formaldehyde	54-66	corticotropin releasing hormone	Mus musculus	74-105
15233757-6	2004	Intrathecal and intravenous injection of ZJ-11 suppressed the expression of Fos-like immunoreactivity, induced by paw formalin injection, in laminae I-II in segments L4-L5 of the spinal cord, suggesting an action on sensory spinal transmission.	Formaldehyde	118-126	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	76-79
15213596-6	2004	We have evaluated the immunohistochemical expression of p16 in a series of formalin-fixed, paraffin-embedded vulvar carcinomas and their putative precursors.	Formaldehyde	75-83	cyclin dependent kinase inhibitor 2A	Homo sapiens	56-59
15234365-6	2004	The competing ring cleavages by O[bond]C-2 and C-4[bond]C-5 bond dissociations combined account for approximately 42% of dissociation and result in the formation of formaldehyde and 2-hydroxyallyl radical.	Formaldehyde	165-177	complement C2	Homo sapiens	39-42
15234365-6	2004	The competing ring cleavages by O[bond]C-2 and C-4[bond]C-5 bond dissociations combined account for approximately 42% of dissociation and result in the formation of formaldehyde and 2-hydroxyallyl radical.	Formaldehyde	165-177	complement C4A (Rodgers blood group)	Homo sapiens	47-50
15234365-6	2004	The competing ring cleavages by O[bond]C-2 and C-4[bond]C-5 bond dissociations combined account for approximately 42% of dissociation and result in the formation of formaldehyde and 2-hydroxyallyl radical.	Formaldehyde	165-177	complement C5	Homo sapiens	56-59
15098015-6	2004	In addition, 47 surgically resected HCCs and 29 metastatic colorectal carcinomas were evaluated for caspase-3 expression by immunohistochemistry on formalin-fixed, paraffin-embedded tissue sections, and the staining intensity was correlated with the clinicopathological features.	Formaldehyde	148-156	caspase 3	Homo sapiens	100-109
15144830-1	2004	The effect of CO(2) atmosphere on the chemical structure changes of resol-type phenol-formaldehyde spheres during pyrolysis was investigated, in comparison with that of N(2) atmosphere, using FT-IR, TGA, and elemental analysis techniques.	Formaldehyde	86-98	T-box transcription factor 1	Homo sapiens	199-202
15290895-2	2004	The accuracy of the method was determined by comparing vIII immunoreactivity in formalin-fixed and paraffin-embedded tumor sections versus RT-PCR results from the analysis of RNA extracted from corresponding frozen specimens.	Formaldehyde	80-88	cytochrome c oxidase subunit 8A	Homo sapiens	55-59
15084755-5	2004	Using this technique, a dose-dependent increase in PMP70 labeling was evident in formalin-fixed liver sections from fenofibrate-treated rats.	Formaldehyde	81-89	ATP binding cassette subfamily D member 3	Rattus norvegicus	51-56
15084755-6	2004	In formalin-fixed liver sections from cynomolgus monkeys given ciprofibrate, quantitative image analysis showed a statistically significant increase in PMP70 labeling compared to control; the increase in hepatic PMP70 protein levels was corroborated by immunoblotting using total liver protein.	Formaldehyde	3-11	ATP binding cassette subfamily D member 3	Rattus norvegicus	152-157
15084755-6	2004	In formalin-fixed liver sections from cynomolgus monkeys given ciprofibrate, quantitative image analysis showed a statistically significant increase in PMP70 labeling compared to control; the increase in hepatic PMP70 protein levels was corroborated by immunoblotting using total liver protein.	Formaldehyde	3-11	ATP binding cassette subfamily D member 3	Rattus norvegicus	212-217
21232219-2	2004	METHODS: c-kit protein expression was detected in 52 formalin-fixed and paraffin-embedded SCLC, 20 non-small cell lung cancer (NSCLC) and 10 normal lung tissues by immunohistochemistry with rabbit antibody to human c-kit protein.	Formaldehyde	53-61	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	9-14
15109976-3	2004	injection of the 5-HT(1A) receptor agonist 8-hydroxy-2-[di-n-propylamino] tetralin (8-OH-DPAT) (1-10 microg) induced analgesic effects in the formalin model of tonic pain whereas in the paw pressure test, it decreased the vocalization threshold.	Formaldehyde	142-150	5-hydroxytryptamine receptor 1A	Rattus norvegicus	17-24
15144342-6	2004	FAS expression was determined using immunohistochemical methods in formalin-fixed and paraffin-embedded cancer specimens.	Formaldehyde	67-75	fatty acid synthase	Homo sapiens	0-3
15155307-8	2004	Formalin injection significantly increased the TNF-alpha mRNA level in the inflamed tissue of the rat hind paw (150%).	Formaldehyde	0-8	tumor necrosis factor	Rattus norvegicus	47-56
15354736-6	2004	A polyclonal antibody to the WT-1 gene product was applied to deparaffinized, formalin-fixed tissue sections after epitope retrieval.	Formaldehyde	78-86	WT1 transcription factor	Homo sapiens	29-33
15126784-2	2004	The quantitative GSTP1 methylation assay, a recently developed methylation specific and polymerase chain reaction based technique, allows the accurate discrimination of benign prostate tissue and prostate cancer even in small, formalin fixed prostate needle biopsies.	Formaldehyde	227-235	glutathione S-transferase pi 1	Homo sapiens	17-22
15269478-6	2004	MATERIALS AND METHODS: p53 protein expression was evaluated on formalin-fixed paraffin-embedded sections using streptavidin biotin immunoperoxidase technique after high temperature antigen retrieval.	Formaldehyde	63-71	tumor protein p53	Homo sapiens	23-26
15503814-0	2004	Optimal conditions for the retrieval of CD4 and CD8 antigens in formalin-fixed, paraffin-embedded tissues.	Formaldehyde	64-72	CD4 molecule	Homo sapiens	40-43
15157693-4	2004	These mice also exhibited CB1 receptor-mediated hypoalgesia in both phases of the formalin test accompanied with a phenotypic anti-edema effect, which was not blocked by either CB1 or CB2 antagonists.	Formaldehyde	82-90	cannabinoid receptor 1 (brain)	Mus musculus	26-29
15178354-0	2004	Interaction of inducible nitric oxide synthase and cyclooxygenase-2 inhibitors in formalin-induced nociception in mice.	Formaldehyde	82-90	nitric oxide synthase 2, inducible	Mus musculus	15-46
15178354-0	2004	Interaction of inducible nitric oxide synthase and cyclooxygenase-2 inhibitors in formalin-induced nociception in mice.	Formaldehyde	82-90	prostaglandin-endoperoxide synthase 2	Mus musculus	51-67
15110333-3	2004	CRP levels increased to a maximum at six or nine days after exposure to formalin for 3.5 h at 300 ppm or 9.5 h at 30 ppm, respectively; these levels are 4.3 and 18 times higher than normal.	Formaldehyde	72-80	c-reactive protein, pentraxin-related	Oncorhynchus mykiss	0-3
15279077-4	2004	METHODS: c-Fos-ir was analyzed by immunohistochemical methods in formaline-fixed, paraffin-embedded sections of rat pancreatic beta cells (BCs), in adrenal medullary chromaffin cells (CCs) that are derived from neural crest, in exocrine pancreatic acinar cells (ACs) that are derived from endoderm, and in adrenal cortex zona reticularis cells (RCs) that are derived from mesoderm.	Formaldehyde	65-74	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	9-14
15138842-4	2004	We have tested commercially available anti-hTERT antibodies in formalin-fixed and paraffin-embedded human tissues by IHC.	Formaldehyde	63-71	telomerase reverse transcriptase	Homo sapiens	43-48
15053933-1	2004	The expression of mRNA encoding interferon-alpha (IFN-alpha) and Mx1 protein was studied, by reverse transcription-polymerase chain reaction and by in-situ hybridization with a non-radioactive digoxigenin-labelled cDNA probe, in formalin-fixed, paraffin wax-embedded lung tissue from pigs experimentally infected with a Korean isolate (North American genotype) of porcine reproductive and respiratory syndrome virus (PRRSV).	Formaldehyde	229-237	interferon-alpha-14	Sus scrofa	32-48
15053933-1	2004	The expression of mRNA encoding interferon-alpha (IFN-alpha) and Mx1 protein was studied, by reverse transcription-polymerase chain reaction and by in-situ hybridization with a non-radioactive digoxigenin-labelled cDNA probe, in formalin-fixed, paraffin wax-embedded lung tissue from pigs experimentally infected with a Korean isolate (North American genotype) of porcine reproductive and respiratory syndrome virus (PRRSV).	Formaldehyde	229-237	interferon-alpha-14	Sus scrofa	50-59
15053933-1	2004	The expression of mRNA encoding interferon-alpha (IFN-alpha) and Mx1 protein was studied, by reverse transcription-polymerase chain reaction and by in-situ hybridization with a non-radioactive digoxigenin-labelled cDNA probe, in formalin-fixed, paraffin wax-embedded lung tissue from pigs experimentally infected with a Korean isolate (North American genotype) of porcine reproductive and respiratory syndrome virus (PRRSV).	Formaldehyde	229-237	MX dynamin like GTPase 1	Sus scrofa	65-68
15503814-0	2004	Optimal conditions for the retrieval of CD4 and CD8 antigens in formalin-fixed, paraffin-embedded tissues.	Formaldehyde	64-72	CD8a molecule	Homo sapiens	48-51
15129118-5	2004	METHODS: Immunohistochemical analysis for transforming growth factor-beta1 and glial cell line-derived neurotrophic factor and their receptors TbetaR II, GFRalpha-1, and Ret was performed on formalin-fixed, paraffin-embedded archival surgical specimens.	Formaldehyde	191-199	ret proto-oncogene	Homo sapiens	170-173
14762097-0	2004	Protein kinase C epsilon and gamma: involvement in formalin-induced nociception in neonatal rats.	Formaldehyde	51-59	protein kinase C, epsilon	Rattus norvegicus	0-34
14762097-3	2004	This study tested the hypothesis that the epsilon and gamma isozymes of protein kinase C (PKC) contribute to formalin-induced nociception in an age-dependent manner.	Formaldehyde	109-117	protein kinase C, epsilon	Rattus norvegicus	90-93
15082126-3	2004	Subcutaneous administration of Anxa1(2-26) into the dorsal surface of the mouse"s hind paw was able to selectively reduce formalin-induced nociceptive behavior in the last phase of the test.	Formaldehyde	122-130	annexin A1	Mus musculus	31-36
15082126-5	2004	Of the shortest Anxa1(2-26)-derived peptides, Anxa1(2-12) reduced the nociceptive response to formalin, however, the Anxa1(2-6) did not.	Formaldehyde	94-102	annexin A1	Mus musculus	16-21
15129118-5	2004	METHODS: Immunohistochemical analysis for transforming growth factor-beta1 and glial cell line-derived neurotrophic factor and their receptors TbetaR II, GFRalpha-1, and Ret was performed on formalin-fixed, paraffin-embedded archival surgical specimens.	Formaldehyde	191-199	glial cell derived neurotrophic factor	Homo sapiens	79-122
15082126-5	2004	Of the shortest Anxa1(2-26)-derived peptides, Anxa1(2-12) reduced the nociceptive response to formalin, however, the Anxa1(2-6) did not.	Formaldehyde	94-102	annexin A1	Mus musculus	46-51
15082179-4	2004	Here we report alterations in CaMKIIalpha mRNA and protein expression in spinal cord tissue from wild-type and heme oxygenase type 2 (HO-2) null mutant mice after formalin injection.	Formaldehyde	163-171	heme oxygenase 2	Mus musculus	111-132
15082126-5	2004	Of the shortest Anxa1(2-26)-derived peptides, Anxa1(2-12) reduced the nociceptive response to formalin, however, the Anxa1(2-6) did not.	Formaldehyde	94-102	annexin A1	Mus musculus	46-51
14766747-3	2004	When overexpressed in Escherichia coli, AtSOX enhanced growth on sarcosine as sole nitrogen source, showing that it has SOX activity in vivo, and the recombinant protein catalyzed the oxidation of sarcosine to glycine, formaldehyde, and H(2) O(2) in vitro.	Formaldehyde	219-231	sulfite oxidase	Arabidopsis thaliana	40-45
14766747-3	2004	When overexpressed in Escherichia coli, AtSOX enhanced growth on sarcosine as sole nitrogen source, showing that it has SOX activity in vivo, and the recombinant protein catalyzed the oxidation of sarcosine to glycine, formaldehyde, and H(2) O(2) in vitro.	Formaldehyde	219-231	sulfite oxidase	Arabidopsis thaliana	42-45
15188393-7	2004	Furthermore, the proteome analysis revealed putative isoenzymes for formaldehyde-activating enzyme Fae, malyl-CoA lyase, malate-dehydrogenase, and fumarase, that need to be characterized functionally in future studies.	Formaldehyde	68-80	MEXAM1_RS07375	Methylobacterium extorquens AM1	121-141
15082179-4	2004	Here we report alterations in CaMKIIalpha mRNA and protein expression in spinal cord tissue from wild-type and heme oxygenase type 2 (HO-2) null mutant mice after formalin injection.	Formaldehyde	163-171	heme oxygenase 2	Mus musculus	134-138
15073847-5	2004	The expression of Cks1 was also examined by immunohistochemistry using formalin-fixed, paraffin-embedded tissue sections from the same patients.	Formaldehyde	71-79	CDC28 protein kinase regulatory subunit 1B pseudogene 7	Homo sapiens	18-22
15219458-3	2004	In vitro stimulation of splenocytes with formalin-killed Staphylococcus aureus resulted in significantly increased production of interleukin-1beta, tumor necrosis factor, and interleukin-12p40 in Galphai2(-/-) as compared to control mice.	Formaldehyde	41-49	guanine nucleotide binding protein (G protein), alpha inhibiting 2	Mus musculus	196-204
15116345-5	2004	These results suggest that FLD1 is involved in the detoxification of formaldehyde in methanol metabolism, and Fld1p coordinates the formaldehyde level in methanol-grown cells according to the methanol concentration on growth.	Formaldehyde	69-81	seipin	Saccharomyces cerevisiae S288C	27-31
15006904-6	2004	Conversely, both phases of nociception induced by 2.5% formalin were inhibited by the bradykinin (BK) B(2) receptor antagonist HOE140 (5 microg lip(-1)) or the selective beta(1)-adrenoceptor antagonist atenolol (100 microg lip(-1)).	Formaldehyde	55-63	adrenoceptor beta 1	Rattus norvegicus	170-190
15006904-11	2004	Our results indicate that BK, TNF-alpha, IL-1 beta, IL-6, IL-8, sympathetic amines and PGs (but not leukotrienes) contribute significantly to formalin-induced orofacial nociception in the rat and the response seems to be more susceptible to inhibition by B(2) receptor antagonist and selective COX-2 inhibitor than by B(1) receptor antagonist or nonselective COX inhibitor.	Formaldehyde	142-150	tumor necrosis factor	Rattus norvegicus	30-39
15006904-11	2004	Our results indicate that BK, TNF-alpha, IL-1 beta, IL-6, IL-8, sympathetic amines and PGs (but not leukotrienes) contribute significantly to formalin-induced orofacial nociception in the rat and the response seems to be more susceptible to inhibition by B(2) receptor antagonist and selective COX-2 inhibitor than by B(1) receptor antagonist or nonselective COX inhibitor.	Formaldehyde	142-150	interleukin 1 beta	Rattus norvegicus	41-50
15006904-11	2004	Our results indicate that BK, TNF-alpha, IL-1 beta, IL-6, IL-8, sympathetic amines and PGs (but not leukotrienes) contribute significantly to formalin-induced orofacial nociception in the rat and the response seems to be more susceptible to inhibition by B(2) receptor antagonist and selective COX-2 inhibitor than by B(1) receptor antagonist or nonselective COX inhibitor.	Formaldehyde	142-150	interleukin 6	Rattus norvegicus	52-56
15006904-11	2004	Our results indicate that BK, TNF-alpha, IL-1 beta, IL-6, IL-8, sympathetic amines and PGs (but not leukotrienes) contribute significantly to formalin-induced orofacial nociception in the rat and the response seems to be more susceptible to inhibition by B(2) receptor antagonist and selective COX-2 inhibitor than by B(1) receptor antagonist or nonselective COX inhibitor.	Formaldehyde	142-150	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	294-299
15033432-1	2004	To test the hypothesis that the hippocampus field CA1 is recruited in nociceptive intensity-dependent fashion in the formalin model of inflammatory pain, we determined the effect of injection of formalin (0.625-2.5%) on the induction of Fos protein along the length of the hippocampus.	Formaldehyde	117-125	carbonic anhydrase 1	Rattus norvegicus	50-53
15033432-1	2004	To test the hypothesis that the hippocampus field CA1 is recruited in nociceptive intensity-dependent fashion in the formalin model of inflammatory pain, we determined the effect of injection of formalin (0.625-2.5%) on the induction of Fos protein along the length of the hippocampus.	Formaldehyde	195-203	carbonic anhydrase 1	Rattus norvegicus	50-53
15033432-1	2004	To test the hypothesis that the hippocampus field CA1 is recruited in nociceptive intensity-dependent fashion in the formalin model of inflammatory pain, we determined the effect of injection of formalin (0.625-2.5%) on the induction of Fos protein along the length of the hippocampus.	Formaldehyde	195-203	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	237-240
15033432-2	2004	Compared to injection of saline, injection of formalin (0.625-2.5%) evoked a concentration-dependent increase in nociceptive behavior and a significant linear increase in the number of Fos-positive cells in the spinal cord, especially in the deeper laminae.	Formaldehyde	46-54	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	185-188
15033432-4	2004	On the other hand, injection of formalin decreased the number of Fos-positive cells in whole CA1, CA3 and dentate gyrus, with a greater significant effect in the posterior-ventral regions of the hippocampus.	Formaldehyde	32-40	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	65-68
15033432-4	2004	On the other hand, injection of formalin decreased the number of Fos-positive cells in whole CA1, CA3 and dentate gyrus, with a greater significant effect in the posterior-ventral regions of the hippocampus.	Formaldehyde	32-40	carbonic anhydrase 1	Rattus norvegicus	93-96
15033432-4	2004	On the other hand, injection of formalin decreased the number of Fos-positive cells in whole CA1, CA3 and dentate gyrus, with a greater significant effect in the posterior-ventral regions of the hippocampus.	Formaldehyde	32-40	carbonic anhydrase 3	Rattus norvegicus	98-101
15033432-5	2004	Indeed, a formalin concentration-dependent decrease was observed in the ventral CA1.	Formaldehyde	10-18	carbonic anhydrase 1	Rattus norvegicus	80-83
15033432-7	2004	Of the regions examined, only the formalin-induced changes in Fos cell counts in the posterior and ventral CA1 were tightly correlated with the changes observed in the spinal cord.	Formaldehyde	34-42	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	62-65
15033432-7	2004	Of the regions examined, only the formalin-induced changes in Fos cell counts in the posterior and ventral CA1 were tightly correlated with the changes observed in the spinal cord.	Formaldehyde	34-42	carbonic anhydrase 1	Rattus norvegicus	107-110
15019688-4	2004	Formalin-fixed paraffin-embedded pre-treatment tissue biopsies were examined immunohistochemically for the over-expression of the HER-2 protein and gene using the HercepTest and FISH assay.	Formaldehyde	0-8	erb-b2 receptor tyrosine kinase 2	Homo sapiens	130-135
15054739-4	2004	METHODS: MUC4 antigens and ErbB2 receptor expression are localized by immunohistochemical studies that use archival formalin-fixed and paraffin-embedded tissue.	Formaldehyde	116-124	mucin 4, cell surface associated	Homo sapiens	9-13
15037120-3	2004	Subcellular localization of ERalpha and ERbeta was determined on formaldehyde-fixed, Saponin-permeabilized cells using conventional immunofluorescence techniques, as well as immunodetection of differential cellular components after subjecting the cultured cells to fractionation by sucrose gradient centrifugation.	Formaldehyde	65-77	estrogen receptor 1	Homo sapiens	28-35
15037120-3	2004	Subcellular localization of ERalpha and ERbeta was determined on formaldehyde-fixed, Saponin-permeabilized cells using conventional immunofluorescence techniques, as well as immunodetection of differential cellular components after subjecting the cultured cells to fractionation by sucrose gradient centrifugation.	Formaldehyde	65-77	estrogen receptor 2	Homo sapiens	40-46
15054739-4	2004	METHODS: MUC4 antigens and ErbB2 receptor expression are localized by immunohistochemical studies that use archival formalin-fixed and paraffin-embedded tissue.	Formaldehyde	116-124	erb-b2 receptor tyrosine kinase 2	Homo sapiens	27-32
15010841-0	2004	Detection of (NAD(P)H:Quinone oxidoreductase-1, EC 1.6.99.2) 609C--&gt;T and 465C--&gt;T polymorphisms in formalin-fixed, paraffin-embedded human tumour tissue using PCR-RFLP.	Formaldehyde	106-114	NAD(P)H quinone dehydrogenase 1	Homo sapiens	14-46
15010841-4	2004	This study describes a method that is suitable for analysing NQO1 polymorphisms in genomic DNA isolated from formalin-fixed paraffin-embedded tissue.	Formaldehyde	109-117	NAD(P)H quinone dehydrogenase 1	Homo sapiens	61-65
15084843-3	2004	The immunohistochemical distribution of c-mos in 159 cases of gynecological lesions and 26 germ cell tumors using formalin-fixed, paraffin-embedded tissues was evaluated.	Formaldehyde	114-122	MOS proto-oncogene, serine/threonine kinase	Homo sapiens	40-45
15107578-7	2004	These results suggested that substance P, neurokinin A, and neurokinin B release accounted for formalin-induced cell migratory activity.	Formaldehyde	95-103	tachykinin precursor 3	Rattus norvegicus	60-72
15088187-2	2004	The fixation process of several formaldehyde-containing solutions was monitored with MRI and MRS at two different temperatures.	Formaldehyde	32-44	MROS	Homo sapiens	93-96
14976524-4	2004	FHIT expression was determined by immunohistochemistry in formalin-fixed paraffin-embedded tissues from 54 squamous cell carcinomas (SCC) and 44 adenocarcinomas (AC) of the lung.	Formaldehyde	58-66	fragile histidine triad diadenosine triphosphatase	Homo sapiens	0-4
15001819-1	2004	Pretreatment of mice with Ro5-4864 or PK11195 inhibited the first- and second-phase responses in the formalin test and this effect was significantly reversed by aminoglutethimide, an inhibitor of pregnenolone synthesis, suggesting that the antinociceptive effect of the peripheral-type benzodiazepine receptor ligands is dependent on steroid formation.	Formaldehyde	101-109	translocator protein	Mus musculus	270-309
15088187-8	2004	MRS confirms a rising concentration of formaldehyde during ongoing fixation.	Formaldehyde	39-51	MROS	Homo sapiens	0-3
15085762-7	2004	In formalin-fixed cell blocks prepared for immunocytochemistry the cells expressed desmin and myf-4.	Formaldehyde	3-11	desmin	Homo sapiens	83-89
15003329-5	2004	Immunization with OVA significantly increased the production of nerve growth factor, but exposure to 80 and 400ppb formaldehyde significantly reduced the nerve growth factor levels in bronchoalveolar lavage fluid of the immunized mice.	Formaldehyde	115-127	nerve growth factor	Mus musculus	154-173
15003329-6	2004	In in vitro study, markedly increased lipopolysaccharide-stimulated interferon-gamma production in culture supernatants of spleen cells from 2000ppb formaldehyde-exposed, nonimmunized mice, and significantly increased OVA-stimulated monocyte chemoattractant protein-1 production in culture supernatants of spleen cells from 400 and 2000ppb formaldehyde-exposed, immunized mice were observed.	Formaldehyde	149-161	interferon gamma	Mus musculus	68-84
15003329-6	2004	In in vitro study, markedly increased lipopolysaccharide-stimulated interferon-gamma production in culture supernatants of spleen cells from 2000ppb formaldehyde-exposed, nonimmunized mice, and significantly increased OVA-stimulated monocyte chemoattractant protein-1 production in culture supernatants of spleen cells from 400 and 2000ppb formaldehyde-exposed, immunized mice were observed.	Formaldehyde	149-161	chemokine (C-C motif) ligand 2	Mus musculus	233-267
15003329-6	2004	In in vitro study, markedly increased lipopolysaccharide-stimulated interferon-gamma production in culture supernatants of spleen cells from 2000ppb formaldehyde-exposed, nonimmunized mice, and significantly increased OVA-stimulated monocyte chemoattractant protein-1 production in culture supernatants of spleen cells from 400 and 2000ppb formaldehyde-exposed, immunized mice were observed.	Formaldehyde	340-352	interferon gamma	Mus musculus	68-84
15003329-7	2004	Exposure to 400ppb formaldehyde induced significant decreases in anti-OVA IgG1 and IgG3 antibody productions in plasma, whereas anti-OVA IgE antibody production was not affected.	Formaldehyde	19-31	immunoglobulin heavy constant gamma 1 (G1m marker)	Mus musculus	74-78
15003329-7	2004	Exposure to 400ppb formaldehyde induced significant decreases in anti-OVA IgG1 and IgG3 antibody productions in plasma, whereas anti-OVA IgE antibody production was not affected.	Formaldehyde	19-31	Immunoglobulin heavy constant gamma 3	Mus musculus	83-87
15003329-8	2004	In addition, the levels of nerve growth factor in plasma of 80 and 400ppb formaldehyde-exposed, immunized mice significantly decreased compared to 0ppb control, immunized mice.	Formaldehyde	74-86	nerve growth factor	Mus musculus	27-46
15085762-7	2004	In formalin-fixed cell blocks prepared for immunocytochemistry the cells expressed desmin and myf-4.	Formaldehyde	3-11	myogenin	Homo sapiens	94-99
14726466-0	2004	Evaluation of oligonucleotide arrays for sequencing of the p53 gene in DNA from formalin-fixed, paraffin-embedded breast cancer specimens.	Formaldehyde	80-88	tumor protein p53	Homo sapiens	59-62
15004699-2	2004	This study analyzed transcript levels of the formaldehyde-metabolizing enzyme alcohol dehydrogenase 3 (ADH3) and various growth and differentiation-related genes in human oral keratinocytes.	Formaldehyde	45-57	alcohol dehydrogenase 1C (class I), gamma polypeptide	Homo sapiens	78-101
15004699-2	2004	This study analyzed transcript levels of the formaldehyde-metabolizing enzyme alcohol dehydrogenase 3 (ADH3) and various growth and differentiation-related genes in human oral keratinocytes.	Formaldehyde	45-57	alcohol dehydrogenase 1C (class I), gamma polypeptide	Homo sapiens	103-107
14726466-2	2004	The purpose of this study was to determine whether a p53 microarray could be used to sequence the p53 gene in DNA extracted from formalin-fixed, paraffin-embedded (FFPE) tissues.	Formaldehyde	129-137	tumor protein p53	Homo sapiens	53-56
14726466-2	2004	The purpose of this study was to determine whether a p53 microarray could be used to sequence the p53 gene in DNA extracted from formalin-fixed, paraffin-embedded (FFPE) tissues.	Formaldehyde	129-137	tumor protein p53	Homo sapiens	98-101
15046365-3	2004	The major degradation pathway involved reduction of RDX to the corresponding mononitroso compound, followed by ring cleavage to yield formaldehyde and methylenedinitramine.	Formaldehyde	134-146	radixin	Homo sapiens	52-55
15014021-2	2004	EXPERIMENTAL DESIGN: Expression of ABC transporter proteins, including P-glycoprotein, multidrug resistance protein (MRP) 1, MRP2, MRP3, and breast cancer resistance protein (BCRP), was examined immunohistochemically in 72 formalin-fixed tumor samples from untreated stage IIIB or IV NSCLC patients.	Formaldehyde	223-231	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	175-179
15163002-3	2004	EGFR gene amplification and chromosome 7 aneuploidy was detected in 34 formalin-fixed, paraffin-embedded benign and malignant gliomas by chromogenic in situ hybridization (CISH) using digoxigenin-labeled EGFR and biotin-labeled chromosome 7 centromeric probes.	Formaldehyde	71-79	epidermal growth factor receptor	Homo sapiens	0-4
14689303-4	2004	Immunohistochemical staining for PTEN protein was performed with the labeled streptavidin-biotin method on formalin-fixed and paraffin-embedded tissue samples.	Formaldehyde	107-115	phosphatase and tensin homolog	Homo sapiens	33-37
14984576-0	2004	HSP47 is a useful marker for skin fibroblasts in formalin-fixed, paraffin-embedded tissue specimens.	Formaldehyde	49-57	serpin family H member 1	Homo sapiens	0-5
14984576-1	2004	AIM: This study was undertaken to assess whether heat-shock protein (HSP)47 is a useful cell marker for skin fibroblasts in formalin-fixed, paraffin-embedded skin specimens.	Formaldehyde	124-132	serpin family H member 1	Homo sapiens	69-75
14993320-2	2004	Previously reported was the purification of an NAD(P)(+)-dependent formaldehyde dehydrogenase (FDH) from the obligate methane-oxidizing methylotroph Methylococcus capsulatus (Bath), presumably important in formaldehyde oxidation, which required a heat-stable factor (known as the modifin) for FDH activity.	Formaldehyde	67-79	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	95-98
14968117-0	2004	Modeling formalin fixation and antigen retrieval with bovine pancreatic ribonuclease A: I-structural and functional alterations.	Formaldehyde	9-17	ribonuclease pancreatic	Bos taurus	72-86
14968117-2	2004	We used biophysical techniques to investigate the effects of formaldehyde treatment on bovine pancreatic ribonuclease A (RNase A).	Formaldehyde	61-73	ribonuclease pancreatic	Bos taurus	105-119
14968117-2	2004	We used biophysical techniques to investigate the effects of formaldehyde treatment on bovine pancreatic ribonuclease A (RNase A).	Formaldehyde	61-73	ribonuclease pancreatic	Bos taurus	121-128
14968117-3	2004	Treatment of RNase A with formaldehyde was shown by gel electrophoresis to lead to the rapid formation of intra- and intermolecular protein cross-links.	Formaldehyde	26-38	ribonuclease pancreatic	Bos taurus	13-20
14968117-5	2004	Analysis of formaldehyde-treated RNase A oligomers isolated by gel chromatography revealed that intramolecular protein cross-links are primarily responsible for the increase in protein thermostability.	Formaldehyde	12-24	ribonuclease pancreatic	Bos taurus	33-40
14968117-8	2004	Heating formaldehyde-treated RNase A at 65 degrees C resulted in a significant reversal of the protein intra- and intermolecular cross-links and led to a partial restoration of enzymatic activity.	Formaldehyde	8-20	ribonuclease pancreatic	Bos taurus	29-36
14767483-0	2004	Modeling formalin fixation and antigen retrieval with bovine pancreatic RNase A II.	Formaldehyde	9-17	ribonuclease pancreatic	Bos taurus	72-79
14767483-2	2004	In this study, gel electrophoresis and capture enzyme-linked immunosorbent assay were used to assess the effect of formaldehyde treatment on the structural and immunological properties of bovine pancreatic ribonuclease A (RNase A).	Formaldehyde	115-127	ribonuclease pancreatic	Bos taurus	222-229
14767483-3	2004	Prolonged incubation of RNase A in a 10% formalin solution leads to the formation of extensive intra- and intermolecular cross-links.	Formaldehyde	41-49	ribonuclease pancreatic	Bos taurus	24-31
14767483-5	2004	Comparative immunotitration of monomers, dimers, and oligomers greater than pentamers isolated from formalin-treated RNase A demonstrated that reduction of immunoreactivity due to intramolecular modifications prevails over the excluded volume effect of intermolecular cross-links.	Formaldehyde	100-108	ribonuclease pancreatic	Bos taurus	117-124
14767483-7	2004	The restoration of RNase A immunoreactivity during heating correlates with the reversal of formaldehyde cross-links if the incubation temperature does not exceed the denaturation temperature of the formalin-treated RNase A preparation.	Formaldehyde	91-103	ribonuclease pancreatic	Bos taurus	19-26
14767483-7	2004	The restoration of RNase A immunoreactivity during heating correlates with the reversal of formaldehyde cross-links if the incubation temperature does not exceed the denaturation temperature of the formalin-treated RNase A preparation.	Formaldehyde	198-206	ribonuclease pancreatic	Bos taurus	19-26
14767483-7	2004	The restoration of RNase A immunoreactivity during heating correlates with the reversal of formaldehyde cross-links if the incubation temperature does not exceed the denaturation temperature of the formalin-treated RNase A preparation.	Formaldehyde	198-206	ribonuclease pancreatic	Bos taurus	215-222
14993320-2	2004	Previously reported was the purification of an NAD(P)(+)-dependent formaldehyde dehydrogenase (FDH) from the obligate methane-oxidizing methylotroph Methylococcus capsulatus (Bath), presumably important in formaldehyde oxidation, which required a heat-stable factor (known as the modifin) for FDH activity.	Formaldehyde	67-79	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	293-296
14993320-5	2004	The FDH preparations were shown to contain a highly active NAD(P)(+)-dependent methylene tetrahydromethanopterin dehydrogenase that was the probable source of the NAD(P)(+)-dependent formaldehyde oxidation activity.	Formaldehyde	183-195	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	4-7
15052310-6	2004	The disappearance of RDX was accompanied by the formation of the mononitroso derivative hexahydro-1-nitroso-3,5-dinitro-1,3,5-triazine (MNX) and formaldehyde (HCHO) that subsequently disappeared.	Formaldehyde	145-157	radixin	Homo sapiens	21-24
15094496-3	2004	Formalin induced hind paw inflammation in the rat resulted in bilateral increase of Fos and NADPH-d expression in the pedunculopontine tegmental nucleus.	Formaldehyde	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	84-87
14985832-0	2004	[MK-801 inhibits formalin-induced cyclooxygenase-2 expression in the dorsal horn of the spinal cord in rats].	Formaldehyde	17-25	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	34-50
14985832-1	2004	To investigate the effect of N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 on the formalin-induced cyclooxygenase-2 (COX-2) expression in the dorsal horn of the rat spinal cord.	Formaldehyde	91-99	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	108-124
14985832-1	2004	To investigate the effect of N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 on the formalin-induced cyclooxygenase-2 (COX-2) expression in the dorsal horn of the rat spinal cord.	Formaldehyde	91-99	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	126-131
14985832-13	2004	The results showed that intrathecal injection of MK-801 significantly inhibited the increase of COX-2 expression in the spinal dorsal horn induced by the formalin injection in a dose-dependent manner, suggesting that the activation of NMDA receptor is one of the mechanisms for the formalin-induced increase of COX-2 expression in the spinal dorsal horn.	Formaldehyde	154-162	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	96-101
14985832-13	2004	The results showed that intrathecal injection of MK-801 significantly inhibited the increase of COX-2 expression in the spinal dorsal horn induced by the formalin injection in a dose-dependent manner, suggesting that the activation of NMDA receptor is one of the mechanisms for the formalin-induced increase of COX-2 expression in the spinal dorsal horn.	Formaldehyde	154-162	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	311-316
14985832-13	2004	The results showed that intrathecal injection of MK-801 significantly inhibited the increase of COX-2 expression in the spinal dorsal horn induced by the formalin injection in a dose-dependent manner, suggesting that the activation of NMDA receptor is one of the mechanisms for the formalin-induced increase of COX-2 expression in the spinal dorsal horn.	Formaldehyde	282-290	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	96-101
14966915-2	2004	METHODS: NDRG1 was detected at its protein level by immunohistochemistry (IHC) and image analysis (IA), and NDRG1 mRNA was detected by in situ hybridization (ISH) in formalin-fixed and paraffin-embedded sections with a total of 190 specimens including 38 normal colorectal mucosae, 31 colorectal adenomas, 45 non-metastatic colorectal carcinomas (CRCs), 38 metastatic primary CRC and subsequently regional lymph nodes respectively.	Formaldehyde	166-174	N-myc downstream regulated 1	Homo sapiens	108-113
15129905-4	2004	E-cadherin staining was performed on 29 formalin-fixed, paraffin-embedded sections from high- and low-grade urothelial carcinoma specimens using an automatic immunohistochemical stainer.	Formaldehyde	40-48	cadherin 1	Homo sapiens	0-10
14610237-13	2004	In summary, the present findings reveal that 1) spinal galanin produces a reliable inhibition of formalin-induced facilitated nociceptive processing, an effect possibly mediated by GalR1 receptors; and 2) galanin potentiates i.t.	Formaldehyde	97-105	galanin and GMAP prepropeptide	Rattus norvegicus	55-62
15000849-6	2004	A total of 16 antibodies were characterized for their reactivity with the nephrin by using ELISA, Western blots, immunoprecipitation and immunostaining of frozen and formaldehyde-fixed paraffin embedded tissue sections.	Formaldehyde	166-178	NPHS1 adhesion molecule, nephrin	Homo sapiens	74-81
14747034-3	2004	STUDY DESIGN: the use of HC-II assay with formaldehyde-fixed paraffin-embedded cervical biopsies, for retrospective studies or to support histological findings, was investigated by analysing three different sample treatments.	Formaldehyde	42-54	serpin family D member 1	Homo sapiens	25-30
14610237-3	2004	administered galanin and its analogs in the formalin test in rats, using an automated flinch detection system.	Formaldehyde	44-52	galanin and GMAP prepropeptide	Rattus norvegicus	13-20
14756816-4	2004	In adult rats, PAM expression was up-regulated in the spinal cord after peripheral nociceptive stimulation using zymosan and formalin injection, suggesting a role for PAM in spinal nociceptive processing.	Formaldehyde	125-133	MYC binding protein 2	Rattus norvegicus	15-18
14610237-4	2004	Intrathecal injection of rat galanin (Gal(1-29)) or human galanin (Gal(1-30)) produced a dose-dependent inhibition of formalin-evoked flinching in phase 2, but not in phase 1.	Formaldehyde	118-126	galanin and GMAP prepropeptide	Rattus norvegicus	29-36
14610237-13	2004	In summary, the present findings reveal that 1) spinal galanin produces a reliable inhibition of formalin-induced facilitated nociceptive processing, an effect possibly mediated by GalR1 receptors; and 2) galanin potentiates i.t.	Formaldehyde	97-105	galanin receptor 1	Rattus norvegicus	181-186
14610237-4	2004	Intrathecal injection of rat galanin (Gal(1-29)) or human galanin (Gal(1-30)) produced a dose-dependent inhibition of formalin-evoked flinching in phase 2, but not in phase 1.	Formaldehyde	118-126	galanin and GMAP prepropeptide	Rattus norvegicus	38-41
14610237-4	2004	Intrathecal injection of rat galanin (Gal(1-29)) or human galanin (Gal(1-30)) produced a dose-dependent inhibition of formalin-evoked flinching in phase 2, but not in phase 1.	Formaldehyde	118-126	galanin and GMAP prepropeptide	Homo sapiens	58-65
14610237-13	2004	In summary, the present findings reveal that 1) spinal galanin produces a reliable inhibition of formalin-induced facilitated nociceptive processing, an effect possibly mediated by GalR1 receptors; and 2) galanin potentiates i.t.	Formaldehyde	97-105	galanin and GMAP prepropeptide	Rattus norvegicus	205-212
14610237-4	2004	Intrathecal injection of rat galanin (Gal(1-29)) or human galanin (Gal(1-30)) produced a dose-dependent inhibition of formalin-evoked flinching in phase 2, but not in phase 1.	Formaldehyde	118-126	galanin and GMAP prepropeptide	Homo sapiens	67-70
14984805-4	2004	NPY dose dependently inhibited the flinching, licking, pressor, and tachycardia responses associated with formalin injection.	Formaldehyde	106-114	neuropeptide Y	Rattus norvegicus	0-3
15059327-2	2004	METHODS: The expression of hTERT protein and hTERT mRNA in the formalin-fixed paraffin-embedded specimens of 71 cases of bile duct cancers and 39 cases of adjacent tissues was detected by streptavidin-peroxidase immunostaining and in situ hybridization.	Formaldehyde	63-71	telomerase reverse transcriptase	Homo sapiens	27-32
15106833-2	2004	The present study examined Fos expression associated with pain-related aversion in rats, using formalin-induced conditioned place avoidance (F-CPA) test, which could distinguish pain emotion from pain sensation.	Formaldehyde	95-103	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	27-30
14744601-4	2004	Peripheral coadministration of a micro-opioid receptor agonist, morphine, with subeffective dose of bovine lactoferrin produced a potentiated antinociceptive effect compared to that of morphine alone during both phases in the formalin test.	Formaldehyde	226-234	lactotransferrin	Bos taurus	107-118
15318940-2	2004	METHODS: We assessed Her-2/neu alteration using CISH on formalin-fixed paraffin-embedded primary invasive ductal carcinoma tumors in which IHC (CB11 antibody) had previously been performed, and we compared the results with IHC.	Formaldehyde	56-64	erb-b2 receptor tyrosine kinase 2	Homo sapiens	21-26
14716825-2	2004	METHODS: ERbeta expression in CRC was investigated by immunohistochemical staining of formalin-fixed, paraffin-embedded tissue sections from 40 CRCs, 10 colonic adenomas, and 10 normal colon mucosa biopsies.	Formaldehyde	86-94	estrogen receptor 2	Homo sapiens	9-15
14697407-11	2004	We speculate that the observed reduced pain behavior in adrenalectomized rats after formalin, is the result of an increased production of pro-opiomelanocortin, the pro-drug of both adrenocorticotrophic hormone and beta-endorphin.	Formaldehyde	84-92	proopiomelanocortin	Rattus norvegicus	138-158
15318940-2	2004	METHODS: We assessed Her-2/neu alteration using CISH on formalin-fixed paraffin-embedded primary invasive ductal carcinoma tumors in which IHC (CB11 antibody) had previously been performed, and we compared the results with IHC.	Formaldehyde	56-64	erb-b2 receptor tyrosine kinase 2	Homo sapiens	27-30
15253134-4	2004	The EGFR expression was visualized in formalin-fixed, paraffin-embedded sections, using immunohistochemistry.	Formaldehyde	38-46	epidermal growth factor receptor	Homo sapiens	4-8
15491060-5	2004	An indirect immunoperoxidase method was applied using polyclonal antibodies against HSP70 and HSP90 on formalin-fixed paraffin-embedded tissues.	Formaldehyde	103-111	heat shock protein 90 alpha family class A member 1	Homo sapiens	94-99
14654948-2	2004	Basal p53 protein levels were measured by immunodetection on both formalin-fixed tumour tissue and from protein extracts of fresh tumours.	Formaldehyde	66-74	transformation related protein 53, pseudogene	Mus musculus	6-9
15467352-0	2004	Inhalation of low-level formaldehyde enhances nerve growth factor production in the hippocampus of mice.	Formaldehyde	24-36	nerve growth factor	Mus musculus	46-65
15050102-4	2004	For the purpose of the study, c-Fos-IR has been analysed by immunohistochemical methods in rat pancreatic beta cells, pulpal undifferentiated ectomesenchimal cells (PUECs) that are known to have a neural crest origin, and in small intestine fibroblasts which do not have a neural crest origin, in formaline-fixed, paraffin-embedded sections.	Formaldehyde	297-306	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	30-35
15467352-1	2004	OBJECTIVE: The effects of low-level formaldehyde (FA) inhalation on the amount of nerve growth factor (NGF) in the hippocampus of immunized mice were studied.	Formaldehyde	36-48	nerve growth factor	Mus musculus	82-101
15103201-5	2004	RESULT: A specific chimeric gene, the SSX-SYT fusion gene, was identified in the formalin-fixed paraffin-embedded surgical specimen using the reverse-transcription polymerase chain reaction (RT-PCR) technique.	Formaldehyde	81-89	SSX family member 2B	Homo sapiens	38-41
15062990-7	2004	At the cortical level, the drug increased metabolic activity in both control and formalin groups in the lacunosus-molecularis layer of the dorsal hippocampus, posterior parietal, retrosplenial, cingulate and frontal cortex; significant metabolic decreases were found in the CA1 region of the dorsal hippocampus and in the parietal 1 and 2 cortical areas.	Formaldehyde	81-89	carbonic anhydrase 1	Rattus norvegicus	274-277
15459490-5	2004	METHODS: Formalin-fixed paraffin-embedded specimens were stained using a monoclonal antibody against syndecan-1.	Formaldehyde	9-17	syndecan 1	Homo sapiens	101-111
15103201-5	2004	RESULT: A specific chimeric gene, the SSX-SYT fusion gene, was identified in the formalin-fixed paraffin-embedded surgical specimen using the reverse-transcription polymerase chain reaction (RT-PCR) technique.	Formaldehyde	81-89	synaptotagmin 1	Homo sapiens	42-45
15188024-5	2004	TTF-1 immunohistochemistry was performed on formalin-fixed, paraffin-embedded tissues.	Formaldehyde	44-52	NK2 homeobox 1	Homo sapiens	0-5
14695135-2	2003	EXPERIMENTAL DESIGN: Using prostatectomy specimens, immunohistochemical staining for PSMA (7E11 antibody) was performed on formalin-fixed paraffin-embedded sections of 136 cases of PCa.	Formaldehyde	123-131	folate hydrolase 1	Homo sapiens	85-89
13680221-4	2004	Immunohistochemical study for COX-2 was carried out using formalin-fixed paraffin-embedded tissues.	Formaldehyde	58-66	prostaglandin-endoperoxide synthase 2	Homo sapiens	30-35
14738509-4	2004	PROCEDURES: Using isoform-specific antibodies, we immunohistochemically evaluated COX-2 expression in formalin-fixed and paraffin-embedded normal (n = 5) and glaucomatous (n = 17) dog eyes.	Formaldehyde	102-110	prostaglandin-endoperoxide synthase 2	Canis lupus familiaris	82-87
14646092-1	2003	S-Formylglutathione hydrolase (SFGH) has activity toward several xenobiotic carboxyesters and catalyses the final step of formaldehyde detoxification: the hydrolysis of S-formylglutathione to formate and glutathione.	Formaldehyde	122-134	S-formylglutathione hydrolase	Arabidopsis thaliana	0-29
14625016-0	2003	Central cyclooxygenase-2 participates in interleukin-1 beta-induced hyperalgesia in the orofacial formalin test of freely moving rats.	Formaldehyde	98-106	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	8-24
14625016-0	2003	Central cyclooxygenase-2 participates in interleukin-1 beta-induced hyperalgesia in the orofacial formalin test of freely moving rats.	Formaldehyde	98-106	interleukin 1 beta	Rattus norvegicus	41-59
14604565-1	2003	In mice immunised intranasally with an inactivated whole-virus influenza (INV) vaccine, or ovalbumin (OVA), formalin-inactivated Bordetella pertussis (Bp) augmented antibody responses to the same degree as did cholera toxin (CT) when simply being mixed with INV or OVA.	Formaldehyde	108-116	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	91-100
14646092-1	2003	S-Formylglutathione hydrolase (SFGH) has activity toward several xenobiotic carboxyesters and catalyses the final step of formaldehyde detoxification: the hydrolysis of S-formylglutathione to formate and glutathione.	Formaldehyde	122-134	S-formylglutathione hydrolase	Arabidopsis thaliana	31-35
14674778-1	2003	The mechanism and kinetics of the gas-phase selective oxidation of methane to formaldehyde (MPO) are revised in the general context of catalytic oxidations.	Formaldehyde	78-90	myeloperoxidase	Homo sapiens	92-95
14576474-8	2003	Mesothelin expression was evaluated in formalin-fixed, paraffin-embedded samples of normal tissues and in 471 tumors of various origins.	Formaldehyde	39-47	mesothelin	Homo sapiens	0-10
14687488-2	2003	METHODS: HIF-1alpha protein expression was determined by immunohistochemistry in formalin-fixed and paraffin-embedded specimens obtained from 13 cases of NP, 28 cases of BPH, and 34 cases of Pca.	Formaldehyde	81-89	hypoxia inducible factor 1 subunit alpha	Homo sapiens	9-19
14769376-9	2003	The c-Fos expression induced by formalin injection in the knockout mice was not different from that observed in wild-type mice.	Formaldehyde	32-40	FBJ osteosarcoma oncogene	Mus musculus	4-9
14959847-4	2003	Up to now, no systematic analysis of the expression pattern of CD56 in formalin fixed paraffin embedded bone marrow biopsies of acute leukemias has been performed.	Formaldehyde	71-79	neural cell adhesion molecule 1	Homo sapiens	63-67
14613328-0	2003	Rational design and synthesis of androgen receptor-targeted nonsteroidal anti-androgen ligands for the tumor-specific delivery of a doxorubicin-formaldehyde conjugate.	Formaldehyde	144-156	androgen receptor	Homo sapiens	33-50
14613328-4	2003	The salicylamide was selected to serve as a trigger release mechanism to separate the doxorubicin-formaldehyde conjugate from the targeting group after it has bound to the androgen receptor.	Formaldehyde	98-110	androgen receptor	Homo sapiens	172-189
14596893-0	2003	Involvement of NMDA receptors in Zif/268 expression in the trigeminal nucleus caudalis following formalin injection into the rat whisker pad.	Formaldehyde	97-105	early growth response 1	Rattus norvegicus	33-40
14596893-2	2003	To this purpose, the effect of the administration of MK-801, an NMDA receptor antagonist, on Zif/268 and c-Fos expression following a noxious stimulus, represented by formalin injection into the whisker pad of rats, was examined in neurons of the trigeminal nucleus caudalis.	Formaldehyde	167-175	early growth response 1	Rattus norvegicus	93-100
14596893-3	2003	Furthermore, the co-localization of formalin injection-evoked Zif/268 and c-Fos expression and subunit 1 of the NMDA receptor (NR1) was studied in this nucleus.	Formaldehyde	36-44	early growth response 1	Rattus norvegicus	62-69
14596893-4	2003	Zif/268 or c-Fos immunoreactivity elicited by formalin injection was significantly reduced by pretreatment with MK-801 in the superficial layer of the trigeminal nucleus caudalis; more than 40% of the neurons expressing Zif/268 and c-Fos in this layer were also immunolabeled by NR1.	Formaldehyde	46-54	early growth response 1	Rattus norvegicus	0-7
14596893-4	2003	Zif/268 or c-Fos immunoreactivity elicited by formalin injection was significantly reduced by pretreatment with MK-801 in the superficial layer of the trigeminal nucleus caudalis; more than 40% of the neurons expressing Zif/268 and c-Fos in this layer were also immunolabeled by NR1.	Formaldehyde	46-54	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	11-16
14596893-4	2003	Zif/268 or c-Fos immunoreactivity elicited by formalin injection was significantly reduced by pretreatment with MK-801 in the superficial layer of the trigeminal nucleus caudalis; more than 40% of the neurons expressing Zif/268 and c-Fos in this layer were also immunolabeled by NR1.	Formaldehyde	46-54	early growth response 1	Rattus norvegicus	220-227
14596893-4	2003	Zif/268 or c-Fos immunoreactivity elicited by formalin injection was significantly reduced by pretreatment with MK-801 in the superficial layer of the trigeminal nucleus caudalis; more than 40% of the neurons expressing Zif/268 and c-Fos in this layer were also immunolabeled by NR1.	Formaldehyde	46-54	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	232-237
14596893-4	2003	Zif/268 or c-Fos immunoreactivity elicited by formalin injection was significantly reduced by pretreatment with MK-801 in the superficial layer of the trigeminal nucleus caudalis; more than 40% of the neurons expressing Zif/268 and c-Fos in this layer were also immunolabeled by NR1.	Formaldehyde	46-54	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	279-282
14663360-5	2003	We investigated, by an immunohistochemical staining method, the expression of hOGG1 protein in 40 cases of CC-RCC, using archival formalin-fixed tissue.	Formaldehyde	130-138	8-oxoguanine DNA glycosylase	Homo sapiens	78-83
14578188-3	2003	With the aim of immunohistochemically localizing PAI-1 in formalin-fixed, paraffin-embedded invasive ductal breast carcinoma samples, we raised new polyclonal antibodies against PAI-1 from different expression systems.	Formaldehyde	58-66	serpin family E member 1	Homo sapiens	49-54
14584070-3	2003	RESULTS: Rates of tumors with low levels of nuclear expression of p27 and p16 were lower during the period 1976-1980 (P &lt; 0.01), suggesting bias due to unbuffered formalin.	Formaldehyde	166-174	zinc ribbon domain containing 2	Homo sapiens	66-69
14602487-6	2003	METHODS: We studied the expression of Cox-2 by immunohistochemistry in 106 primary breast carcinoma specimens collected over a three-year period, using a commercially available polyclonal antibody on formalin-fixed, paraffin-embedded tissue.	Formaldehyde	200-208	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
14585093-5	2003	METHODS: Gal3 immunoperoxidase reaction was carried out on 91 sections of thyroid gland samples fixed in formalin and embedded in paraffin.	Formaldehyde	105-113	galectin 3	Homo sapiens	9-13
14568798-7	2003	INTERVENTIONS: Expression of VEGF-A and VEGF-C was determined by immunohistochemistry on formalin-fixed, paraffin-embedded biopsy specimens.	Formaldehyde	89-97	vascular endothelial growth factor A	Homo sapiens	29-35
14636817-8	2003	In contrast, GDNF treatment only reversed behavioral responses to chemogenic stimuli during the acute phase of the formalin test.	Formaldehyde	115-123	glial cell line derived neurotrophic factor	Mus musculus	13-17
14499963-2	2003	Rats treated with a single injection of mGluR1 antisense ODNs into the intrathecal space of the lumbar spinal cord showed a marked reduction of the early-sustained phase of formalin-induced nociceptive responses, but not of their acute phase.	Formaldehyde	173-181	glutamate metabotropic receptor 1	Rattus norvegicus	40-46
14499963-7	2003	These results suggest that mGluR1 may play a crucial role in the sustained nociception of formalin-induced behavioral responses.	Formaldehyde	90-98	glutamate metabotropic receptor 1	Rattus norvegicus	27-33
14963899-15	2003	The SDH activity in testicle tissue was declined in all formaldehyde groups; There were a significant decline of copper and zinc in testicle tissue in high dose group.	Formaldehyde	56-68	serine dehydratase	Mus musculus	4-7
14566407-5	2003	(2) Formalin-induced sigmoid pain scores and the expression of Fos in the spinal cord at S1 segment were decreased after microinjecting L-NAME into the DR.	Formaldehyde	4-12	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	63-66
14499961-11	2003	The cannabinoid agonist suppressed formalin-evoked Fos protein expression, a marker of neuronal activity, in the lumbar dorsal horn of sham-operated rats, but no suppression was observed in lesioned rats.	Formaldehyde	35-43	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	51-54
14499961-12	2003	The number of formalin-evoked Fos-like immunoreactive (FLI) cells was greater in lamina I and II of lesioned rats relative to sham-operated rats.	Formaldehyde	14-22	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	30-33
14499961-13	2003	These data indicate that the suppressive effect of the cannabinoid on formalin-evoked Fos protein expression in the superficial dorsal horn was attenuated following destruction of descending noradrenergic pathways.	Formaldehyde	70-78	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	86-89
14499963-0	2003	Antisense knockdown of spinal-mGluR1 reduces the sustained phase of formalin-induced nociceptive responses.	Formaldehyde	68-76	glutamate metabotropic receptor 1	Rattus norvegicus	30-36
14568798-7	2003	INTERVENTIONS: Expression of VEGF-A and VEGF-C was determined by immunohistochemistry on formalin-fixed, paraffin-embedded biopsy specimens.	Formaldehyde	89-97	vascular endothelial growth factor C	Homo sapiens	40-46
14505311-7	2003	RESULTS: Fixing cells with 1.5% formaldehyde followed by permeabilization in methanol gave optimal results for pERK, pp38, pJNK, pStat1, pStat5, and pStat6 staining.	Formaldehyde	32-44	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	111-115
13130519-9	2003	In addition, the nonparallel suppression of BmK IT2 on flinch behavior and c-Fos expression induced by formalin may be ascribed to the different activity patterns of afferent fibers and central neurons.	Formaldehyde	103-111	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	75-80
14622196-5	2003	injection of formalin as a chemical somatic noxious stimulus increased c-fos mRNA expression in the BLA, but not CeA, while intraperitoneal (i.p.)	Formaldehyde	13-21	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	71-76
14619585-6	2003	CONCLUSION: Intrathecal neostigmine could induce nitric oxide release in the spinal cord, the suppression of Fos expression might be one of the antinociception mechanisms of intrathecal neostigmine in the formalin test.	Formaldehyde	205-213	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	109-112
12941373-6	2003	This anti-nociceptive effect was accompanied by an HU210-induced attenuation of the formalin-evoked increase in Fos protein expression in the caudal lateral PAG.	Formaldehyde	84-92	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	112-115
13130519-0	2003	Suppressive effects of BmK IT2 on nociceptive behavior and c-Fos expression in spinal cord induced by formalin.	Formaldehyde	102-110	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	59-64
13130519-3	2003	The detection of c-Fos expression induced by formalin in either the absence or the presence of BmK IT2 was carried out with the ABC method.	Formaldehyde	45-53	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	17-22
13130519-7	2003	In addition, c-Fos expression induced by formalin was significantly inhibited in all laminae of L4-5 spinal cord by pre- or posttreatment with BmK IT2.	Formaldehyde	41-49	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	13-18
12914986-5	2003	CART produces antinociception in the formalin test in both phases.	Formaldehyde	37-45	CART prepropeptide	Rattus norvegicus	0-4
12963492-2	2003	Model systems using formaldehyde-modified albumin (f-Alb) have shown an impairment in RME following chronic alcohol consumption utilizing both in situ perfused rat livers and isolated rat liver endothelial cells (LECs).	Formaldehyde	20-32	albumin	Rattus norvegicus	53-56
12886520-4	2003	Caspase-3 levels in formalin-fixed, paraffin-embedded specimens were quantified using immunohistochemical detection and video image analysis.	Formaldehyde	20-28	caspase 3	Homo sapiens	0-9
14601197-2	2003	METHODS: The antinociceptive effects were assessed in male Sprague-Dawley rats by behavioral responses to phasic and tonic nociceptive stimulations and biochemical index of pain, formalin-induced Fos-like immunoreactivity (Fos-LI), in spinal cord dorsal horn.	Formaldehyde	179-187	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	196-199
14601197-2	2003	METHODS: The antinociceptive effects were assessed in male Sprague-Dawley rats by behavioral responses to phasic and tonic nociceptive stimulations and biochemical index of pain, formalin-induced Fos-like immunoreactivity (Fos-LI), in spinal cord dorsal horn.	Formaldehyde	179-187	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	223-226
12954872-10	2003	Next, we found that pretreatment with PLC inhibitors, mGluR1 antagonists, or both, by either intracerebroventricular or intrathalamic injection, attenuated the formalin-induced pain behavior in the second phase in wild-type mice.	Formaldehyde	160-168	glutamate receptor, metabotropic 1	Mus musculus	54-60
14506155-5	2003	EXPERIMENTAL DESIGN: We analyzed ARHI expression in DCIS, invasive breast carcinoma, and adjacent normal breast epithelium from 64 formalin-fixed, paraffin-embedded DCIS specimens by both immunohistochemistry and in situ hybridization.	Formaldehyde	131-139	DIRAS family GTPase 3	Homo sapiens	33-37
12954872-14	2003	These findings indicate that the thalamic mGluR1-PLCbeta4 cascade is indispensable for the formalin-induced inflammatory pain by regulating the response of VPL neurons.	Formaldehyde	91-99	glutamate receptor, metabotropic 1	Mus musculus	42-48
14626695-9	2003	Identification of these inclusions and other specific lesions in parkinsonian disorders is facilitated by the routine application on formalin fixed brain of immunohistochemistry for alpha-synuclein, tau and ubiquitin.	Formaldehyde	133-141	synuclein alpha	Homo sapiens	182-197
14572158-2	2003	The expression of VEGF and MVD was assessed on tissue sections formalin-fixed and paraffin-embedded by immunohistochemical staining using anti-VEGF antibody of human origin and anti-CD34 monoclonal antibody.	Formaldehyde	63-71	vascular endothelial growth factor A	Homo sapiens	18-22
12888898-1	2003	In this study expression of protein kinase C alpha (PKCalpha), delta (PKCdelta) and iota (PKCiota) was determined immunohistochemically in formalin-fixed paraffin-embedded tissue specimen of ovarian cystadenomas (n=7), borderline tumours of the ovary (n=8), primary (n=54) and recurrent invasive ovarian carcinomas (n=13).	Formaldehyde	139-147	protein kinase C alpha	Homo sapiens	52-60
12930346-1	2003	Described here is the use of detecting TLS/FUS-CHOP fusion transcripts to confirm the diagnosis of a myxoid liposarcoma by nested reverse transcription-polymerase chain reaction assay using archival formalin-fixed, paraffin-embedded tissues of a young man with a benign-looking myxoid tumor on his upper extremity, which is often misdiagnosed clinically or histopathologically as a benign tumor.	Formaldehyde	199-207	FUS RNA binding protein	Homo sapiens	39-42
12960692-3	2003	Histopathologists, who usually use formalin-fixed tissues, may be confronted with the need to investigate the BCR-ABL rearrangement when evaluating tumor forming infiltrates and bone marrow trephines from patients presenting with chronic myeloproliferative disorders.	Formaldehyde	35-43	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	110-117
12960695-9	2003	In conclusion, RT in situ PCR for TCRbeta, which can be done on formalin-fixed biopsies and allows direct correlation of the molecular data with the histology, is a useful adjunctive test in the differentiation of CTCL from its mimics.	Formaldehyde	64-72	T cell receptor beta locus	Homo sapiens	34-41
12888898-1	2003	In this study expression of protein kinase C alpha (PKCalpha), delta (PKCdelta) and iota (PKCiota) was determined immunohistochemically in formalin-fixed paraffin-embedded tissue specimen of ovarian cystadenomas (n=7), borderline tumours of the ovary (n=8), primary (n=54) and recurrent invasive ovarian carcinomas (n=13).	Formaldehyde	139-147	protein kinase C delta	Homo sapiens	70-78
12930690-1	2003	OBJECTIVE: To detect the PAX3-FKHR and PAX7-FKHR fusion transcripts in formalin-fixed, paraffin-embedded rhabdomyosarcoma tissues by one-step RT-PCR and discuss its diagnostic potential.	Formaldehyde	71-79	paired box 3	Homo sapiens	25-29
12941892-0	2003	Enhanced disease and pulmonary eosinophilia associated with formalin-inactivated respiratory syncytial virus vaccination are linked to G glycoprotein CX3C-CX3CR1 interaction and expression of substance P.	Formaldehyde	60-68	chemokine (C-X3-C motif) ligand 1	Mus musculus	150-154
12941892-0	2003	Enhanced disease and pulmonary eosinophilia associated with formalin-inactivated respiratory syncytial virus vaccination are linked to G glycoprotein CX3C-CX3CR1 interaction and expression of substance P.	Formaldehyde	60-68	chemokine (C-X3-C motif) receptor 1	Mus musculus	155-161
12941892-0	2003	Enhanced disease and pulmonary eosinophilia associated with formalin-inactivated respiratory syncytial virus vaccination are linked to G glycoprotein CX3C-CX3CR1 interaction and expression of substance P.	Formaldehyde	60-68	tachykinin 1	Mus musculus	192-203
14582702-6	2003	The expression of the COX-2 protein was immunohistochemically examined on formalin-fixed and paraffin-embedded tissue sections using an anti-COX-2 antibody and an avidin-biotin complex method.	Formaldehyde	74-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
12950462-2	2003	There was a rapid increase in phosphorylated p38 MAPK in spinal cord following intrathecal administration of substance P or intradermal injection of formalin.	Formaldehyde	149-157	mitogen-activated protein kinase 14	Homo sapiens	45-48
12893178-2	2003	However, formaldehyde alone has proved inadequate for crosslinking of certain proteins such as the yeast histone deacetylase Rpd3.	Formaldehyde	9-21	histone deacetylase RPD3	Saccharomyces cerevisiae S288C	125-129
12873732-0	2003	Analgesic effect of intrathecally administered matrix metalloproteinase 2 (MMP-2) in the rat formalin test.	Formaldehyde	93-101	matrix metallopeptidase 2	Rattus norvegicus	47-73
12873732-0	2003	Analgesic effect of intrathecally administered matrix metalloproteinase 2 (MMP-2) in the rat formalin test.	Formaldehyde	93-101	matrix metallopeptidase 2	Rattus norvegicus	75-80
12873732-2	2003	In the present study, the authors examined the effect of intrathecal injection of MMP-2 on the nociceptive transmission during the rat formalin test (a model of inflammatory pain).	Formaldehyde	135-143	matrix metallopeptidase 2	Rattus norvegicus	82-87
12873732-6	2003	These data suggest that exogenously applied MMP-2 to the spinal cord produces analgesic effects in the rat formalin test.	Formaldehyde	107-115	matrix metallopeptidase 2	Rattus norvegicus	44-49
12930690-1	2003	OBJECTIVE: To detect the PAX3-FKHR and PAX7-FKHR fusion transcripts in formalin-fixed, paraffin-embedded rhabdomyosarcoma tissues by one-step RT-PCR and discuss its diagnostic potential.	Formaldehyde	71-79	paired box 7	Homo sapiens	39-43
12930690-1	2003	OBJECTIVE: To detect the PAX3-FKHR and PAX7-FKHR fusion transcripts in formalin-fixed, paraffin-embedded rhabdomyosarcoma tissues by one-step RT-PCR and discuss its diagnostic potential.	Formaldehyde	71-79	forkhead box O1	Homo sapiens	44-48
12921727-1	2003	The expression of mRNA encoding interleukin-10 (IL-10) and IL-12 was studied, by the reverse transcription-polymerase chain reaction and by in-situ hybridization with a non-radioactive digoxigenin-labelled cDNA probe, in formalin-fixed, paraffin wax-embedded lung tissue from piglets inoculated intranasally with a Korean isolate (North American genotype) of porcine reproductive and respiratory syndrome virus (PRRSV).	Formaldehyde	221-229	interleukin 10	Homo sapiens	48-53
12859744-5	2003	Formalin-fixed, paraffin-embedded archival tissue from these cases was immunostained for p53 and used for DNA extraction for the analysis of p53 mutations by polymerase chain reaction and single-strand conformation polymorphism.	Formaldehyde	0-8	tumor protein p53	Homo sapiens	89-92
12931590-3	2003	The abscess was debrided and gelatin-resorcin-formalin glue (GRF glue) was injected into the abscess cavity.	Formaldehyde	46-54	growth hormone releasing hormone	Homo sapiens	61-64
12904537-1	2003	The methylotrophic yeast Candida boidinii exhibits S-formylglutathione hydrolase activity (FGH, EC 3.1.2.12), which is involved in the glutathione-dependent formaldehyde oxidation pathway during growth on methanol as the sole carbon source.	Formaldehyde	157-169	S-formylglutathione hydrolase	Saccharomyces cerevisiae S288C	51-80
12927630-9	2003	TNF and formalin evoked intramuscular upregulation of CGRP and NGF, whereas PGE2 was increased exclusively after TNF injection.	Formaldehyde	8-16	calcitonin-related polypeptide alpha	Rattus norvegicus	54-58
12913179-0	2003	Enhanced formaldehyde detoxification by overexpression of glutathione-dependent formaldehyde dehydrogenase from Arabidopsis.	Formaldehyde	9-21	GroES-like zinc-binding dehydrogenase family protein	Arabidopsis thaliana	80-106
12913179-1	2003	The ADH2 gene codes for the Arabidopsis glutathione-dependent formaldehyde dehydrogenase (FALDH), an enzyme involved in formaldehyde metabolism in eukaryotes.	Formaldehyde	62-74	GroES-like zinc-binding dehydrogenase family protein	Arabidopsis thaliana	4-8
12913179-1	2003	The ADH2 gene codes for the Arabidopsis glutathione-dependent formaldehyde dehydrogenase (FALDH), an enzyme involved in formaldehyde metabolism in eukaryotes.	Formaldehyde	62-74	GroES-like zinc-binding dehydrogenase family protein	Arabidopsis thaliana	90-95
12913179-2	2003	In the present work, we have investigated the potential role of FALDH in detoxification of exogenous formaldehyde.	Formaldehyde	101-113	GroES-like zinc-binding dehydrogenase family protein	Arabidopsis thaliana	64-69
12913179-4	2003	Overexpression of Arabidopsis FALDH in this mutant confers high resistance to formaldehyde added exogenously, which demonstrates the functional conservation of the enzyme through evolution and supports its essential role in formaldehyde metabolism.	Formaldehyde	78-90	GroES-like zinc-binding dehydrogenase family protein	Arabidopsis thaliana	30-35
12913179-4	2003	Overexpression of Arabidopsis FALDH in this mutant confers high resistance to formaldehyde added exogenously, which demonstrates the functional conservation of the enzyme through evolution and supports its essential role in formaldehyde metabolism.	Formaldehyde	224-236	GroES-like zinc-binding dehydrogenase family protein	Arabidopsis thaliana	30-35
12913179-6	2003	Plants overexpressing the enzyme show a 25% increase in their efficiency to take up exogenous formaldehyde, whereas plants with reduced levels of FALDH (due to either a cosuppression phenotype or to the expression of an antisense construct) show a marked slower rate and reduced ability for formaldehyde detoxification as compared with the wild-type Arabidopsis.	Formaldehyde	291-303	GroES-like zinc-binding dehydrogenase family protein	Arabidopsis thaliana	146-151
12913179-7	2003	These results show that the capacity to take up and detoxify high concentrations of formaldehyde is proportionally related to the FALDH activity in the plant, revealing the essential role of this enzyme in formaldehyde detoxification.	Formaldehyde	84-96	GroES-like zinc-binding dehydrogenase family protein	Arabidopsis thaliana	130-135
12913179-7	2003	These results show that the capacity to take up and detoxify high concentrations of formaldehyde is proportionally related to the FALDH activity in the plant, revealing the essential role of this enzyme in formaldehyde detoxification.	Formaldehyde	206-218	GroES-like zinc-binding dehydrogenase family protein	Arabidopsis thaliana	130-135
12834907-4	2003	Fos expression in the dorsal horn after injection of formalin into the hindpaw was severely attenuated by neonatal capsaicin treatment.	Formaldehyde	53-61	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-3
12853634-9	2003	In the presence of DNA damage in S phase cells, the distribution of kin17 protein became mainly associated with chromosomal DNA, as judged by limited formaldehyde cross-linking of living cells.	Formaldehyde	150-162	Kin17 DNA and RNA binding protein	Homo sapiens	68-73
12860408-3	2003	Primary amino groups of Lys and Hyl were N-methylated by formaldehyde in reducing conditions or N-acetylated by sulfosuccinimidyl acetate.	Formaldehyde	57-69	megakaryocyte-associated tyrosine kinase	Homo sapiens	32-35
12835417-8	2003	sialorphin elicited potent antinociceptive responses in two behavioral rat models of injury-induced acute and tonic pain, the pin-pain test and formalin test.	Formaldehyde	144-152	submaxillary gland androgen regulated protein 3B	Rattus norvegicus	0-10
12866377-0	2003	Minimum formalin fixation time for consistent estrogen receptor immunohistochemical staining of invasive breast carcinoma.	Formaldehyde	8-16	estrogen receptor 1	Homo sapiens	46-63
12812839-4	2003	We found that intraplantar injection of formalin as a chemical somatic noxious stimulus increased c-fos mRNA expression in the La and BL, but not Ce.	Formaldehyde	40-48	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	98-103
12866377-7	2003	The minimum formalin fixation time for reliable immunohistochemical ER results is 6 to 8 hours in our laboratory, regardless of the type or size of specimen.	Formaldehyde	12-20	estrogen receptor 1	Homo sapiens	68-70
12782039-1	2003	The aim of this study was to detect crosslinks of collagen and elastin in formalin-fixed tissue, to perform quantification of these crosslinks, and to investigate the effects of formalin fixation on crosslink contents in human yellow ligament and cartilage.	Formaldehyde	74-82	elastin	Homo sapiens	63-70
12782039-6	2003	If it is possible to evaluate crosslinks of collagen and elastin in formalin-fixed tissues, we can investigate crosslinks in a wide variety of tissues.	Formaldehyde	68-76	elastin	Homo sapiens	57-64
12782039-11	2003	The reason for this might be that formalin did not fix elastin tissues sufficiently or it destroyed, masked, or altered elastin crosslinks.	Formaldehyde	34-42	elastin	Homo sapiens	120-127
12808141-4	2003	In models of inflammatory pain, CCR2 knockout mice showed a 70% reduction in phase 2 of the intraplantar formalin-evoked pain response but only a modest (20-30%) and nonsignificant reduction of mechanical allodynia after intraplantar Freund"s adjuvant (CFA).	Formaldehyde	105-113	chemokine (C-C motif) receptor 2	Mus musculus	32-36
12821344-5	2003	METHODS: Using immunohistochemistry, we investigated FasL expression in sections of formalin-fixed, paraffin-embedded tissue from 24 cervical adenocarcinomas.	Formaldehyde	84-92	Fas ligand	Homo sapiens	53-57
12719976-6	2003	Using this technique, the formalin-fixed, paraffin-embedded human and rat normal liver tissue sections showed the vinculin immunoreactivity along the sinusoidal wall.	Formaldehyde	26-34	vinculin	Rattus norvegicus	114-122
12855312-6	2003	In intact rats, c-Fos expression in the paraventricular nucleus of the thalamus and arcuate nucleus of the hypothalamus remained at control levels or decreased in animals injected two or three times with formalin; in gonadectomized rats, c-Fos expression increased with repetition of the noxious stimulation, reaching the highest levels in animals injected three times with formalin.	Formaldehyde	204-212	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	16-21
12855312-6	2003	In intact rats, c-Fos expression in the paraventricular nucleus of the thalamus and arcuate nucleus of the hypothalamus remained at control levels or decreased in animals injected two or three times with formalin; in gonadectomized rats, c-Fos expression increased with repetition of the noxious stimulation, reaching the highest levels in animals injected three times with formalin.	Formaldehyde	204-212	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	238-243
12855312-6	2003	In intact rats, c-Fos expression in the paraventricular nucleus of the thalamus and arcuate nucleus of the hypothalamus remained at control levels or decreased in animals injected two or three times with formalin; in gonadectomized rats, c-Fos expression increased with repetition of the noxious stimulation, reaching the highest levels in animals injected three times with formalin.	Formaldehyde	374-382	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	16-21
12855325-0	2003	In vivo electroporation of proopiomelanocortin induces analgesia in a formalin-injection pain model in rats.	Formaldehyde	70-78	proopiomelanocortin	Rattus norvegicus	27-46
12910709-0	2003	[Effect of Fos expression induced by spinal nitric oxide on the nociception of formalin in rats].	Formaldehyde	79-87	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	11-14
12778001-6	2003	Monoclonal antibody 5.8A for MyoD1 was used on a series of cases of formalin-fixed, paraffin-embedded angiomyolipoma (n = 19), lymphangioleiomyomatosis (n = 3), clear cell sugar tumor of the lung (n = 1), and abdominopelvic sarcoma of perivascular epithelioid cells (n = 2).	Formaldehyde	68-76	myogenic differentiation 1	Homo sapiens	29-34
12759135-1	2003	In this study, we evaluated the effects of intrathecally administered agonists of mu- and delta-opioid receptor and their analogs on the pain-induced behavior and expression of c-Fos immunoreactivity in the spinal cord, elicited by intraplantar injection of 12% formalin to the hindpaw of the rat.	Formaldehyde	262-270	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	177-182
12759135-3	2003	In this study, intrathecal injection of morphine (10 microg), endomorphin-2 (5 microg) and its analog Dmt-endomorphin-2 (10 microg) significantly decreased the formalin-induced pain behavior, and lowered a number of c-Fos positive neurons in the laminae I, II and III of the spinal cord by about 40%, 30% and 40%, respectively.	Formaldehyde	160-168	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	216-221
12766578-5	2003	We performed immunohistochemistry using a polyclonal antibody to the C-terminal portion of TFE3 in 40 formalin-fixed, paraffin-embedded tumors characterized by TFE3 gene fusions, including 19 alveolar soft part sarcoma (of which nine were molecularly confirmed) and 21 renal carcinomas with cytogenetically confirmed characteristic Xp11.2 translocations and/or fusion transcripts involving TFE3 (11 PRCC-TFE3, 7 ASPL-TFE3, 3 PSF-TFE3).	Formaldehyde	102-110	transcription factor binding to IGHM enhancer 3	Homo sapiens	91-95
12798704-2	2003	METHODS: In 47 formalin fixed, paraffin-embedded tissues from adenocarcinoma of the uterine cervix which had been treated with radiation (1970-1995), PD-ECGF and VEGF expressions were determined using immunohistochemistry, and the relationships between PD-ECGF or VEGF expressions and local control or survival were assessed.	Formaldehyde	15-23	vascular endothelial growth factor A	Homo sapiens	162-166
12846417-2	2003	Recently an immunohistochemical (IHC) method for ODC determinations in formalin-fixed paraffin-embedded tissues has been developed.	Formaldehyde	71-79	ornithine decarboxylase 1	Homo sapiens	49-52
12814369-9	2003	However, NOP-R-/-, ppN/OFQ-/- and double knockout mice showed markedly stronger nociceptive responses during prolonged nociceptive stimulation in the second phase of the formalin test and significantly lower thermal pain thresholds in inflamed tissue after zymosan A injection.	Formaldehyde	170-178	porcupine O-acyltransferase	Mus musculus	19-22
12872724-6	2003	Beta-catenin accumulation was examined immunohistochemically in 49 frozen or formalin-fixed, paraffin-embedded samples of head and neck tumors.	Formaldehyde	77-85	catenin beta 1	Homo sapiens	0-12
12750014-6	2003	Subcutaneous (s.c.) injection of 5% formalin in the bilateral hind paws caused a moderate increase of GALP gene expression in the PP.	Formaldehyde	36-44	galanin-like peptide	Rattus norvegicus	102-106
12787847-9	2003	However, 200 pg Tnf-alpha injected intracisternally significantly increased the number of noxious behavioral responses produced by formalin injection in both the early and late phases, and 2 ng Tnf-alpha increased formalin induced noxious behavioral responses in only the late phase.	Formaldehyde	131-139	tumor necrosis factor	Rattus norvegicus	16-25
12787847-9	2003	However, 200 pg Tnf-alpha injected intracisternally significantly increased the number of noxious behavioral responses produced by formalin injection in both the early and late phases, and 2 ng Tnf-alpha increased formalin induced noxious behavioral responses in only the late phase.	Formaldehyde	214-222	tumor necrosis factor	Rattus norvegicus	194-203
12750263-3	2003	We have now generated a monoclonal antibody useful for the detection of ERbeta at the protein level in archival, formalin-fixed breast tumors and have examined its expression using immunohistochemistry in a pilot series of 242 breast cancer patients.	Formaldehyde	113-121	estrogen receptor 2	Homo sapiens	72-78
12719537-9	2003	Intracerebroventricular injection of NPB produces analgesia to s.c. formalin injection in rats.	Formaldehyde	68-76	neuropeptide B	Rattus norvegicus	37-40
12771391-0	2003	DNA-protein crosslinks and p53 protein expression in relation to occupational exposure to formaldehyde.	Formaldehyde	90-102	tumor protein p53	Homo sapiens	27-30
12706686-4	2003	Two doses of a formalin-inactivated G9/PR8 virus vaccine induced hemagglutination inhibiting antibodies and conferred complete protection against challenge with G9 and the antigenically distinct H9N2 A/Hong Kong/1073/99 (G1-like) virus in a mouse model.	Formaldehyde	15-23	neuraminidase 1	Mus musculus	36-42
12760288-11	2003	p63 and TTF-1 appear to be useful for differentiating SCLC from lung PDSCC in formalin-fixed and alcohol-fixed, formalin-postfixed material.	Formaldehyde	78-86	tumor protein p63	Homo sapiens	0-3
12769381-3	2003	An FDH/Os-polymer electrode responded linearly over the concentration range of 2 x 10(-6)-5 x 10(-4) M for formaldehyde, while an ADH/Os-polymer electrode, though responding similarly to long chain aldehydes, such as propionaldehyde and butylaldehyde, responded linearly over the concentration range of 4 x 10(-6)-2 x 10(-4) M for acetaldehyde.	Formaldehyde	107-119	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	3-6
12760288-11	2003	p63 and TTF-1 appear to be useful for differentiating SCLC from lung PDSCC in formalin-fixed and alcohol-fixed, formalin-postfixed material.	Formaldehyde	78-86	NK2 homeobox 1	Homo sapiens	8-13
12760288-11	2003	p63 and TTF-1 appear to be useful for differentiating SCLC from lung PDSCC in formalin-fixed and alcohol-fixed, formalin-postfixed material.	Formaldehyde	112-120	tumor protein p63	Homo sapiens	0-3
12760288-11	2003	p63 and TTF-1 appear to be useful for differentiating SCLC from lung PDSCC in formalin-fixed and alcohol-fixed, formalin-postfixed material.	Formaldehyde	112-120	NK2 homeobox 1	Homo sapiens	8-13
12695161-3	2003	MIF expression was evaluated by immunohistochemistry on formalin fixed skin biopsies of patients with dSSc and controls.	Formaldehyde	56-64	macrophage migration inhibitory factor	Homo sapiens	0-3
12894514-3	2003	Her2/neu levels were immunohistochemically detected on formalin-fixed, paraffin-embedded tissues using c-erbB-2/Her2/neu Oncoprotein Ab-17 monoclonal antibody(mAb).	Formaldehyde	55-63	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-4
12894498-4	2003	In our series of 6 patients with MTC, including 5 patients with adjacent C-cell hyperplasia, Her2/neu levels were immunohistochemically evaluated on formalin-fixed, paraffin-embedded tissues using c-erbB-2/Her-2/neu Oncoprotein Ab-17 monoclonal antibody(mAb).	Formaldehyde	149-157	erb-b2 receptor tyrosine kinase 2	Homo sapiens	93-101
12894514-3	2003	Her2/neu levels were immunohistochemically detected on formalin-fixed, paraffin-embedded tissues using c-erbB-2/Her2/neu Oncoprotein Ab-17 monoclonal antibody(mAb).	Formaldehyde	55-63	erb-b2 receptor tyrosine kinase 2	Homo sapiens	5-8
12894514-3	2003	Her2/neu levels were immunohistochemically detected on formalin-fixed, paraffin-embedded tissues using c-erbB-2/Her2/neu Oncoprotein Ab-17 monoclonal antibody(mAb).	Formaldehyde	55-63	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-8
12738649-12	2003	Both anti-P46 and anti-P65(c) MAbs permitted effective detection by indirect immunofluorescence and indirect immunoperoxidase assay of M. hyopneumoniae in, respectively, frozen and formalin-fixed, paraffin-embedded lung sections from pigs that were killed after the 6- to 7-week observation period.	Formaldehyde	181-189	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	23-26
12562764-3	2003	To identify important Egr1 target genes, we have adapted a methodology involving formaldehyde-induced protein-DNA cross-linking, chromatin immunoprecipitation, and multiplex PCR.	Formaldehyde	81-93	early growth response 1	Homo sapiens	22-26
12738726-3	2003	Immunohistochemical staining of 51 formalin-fixed RCC lesions and autologous normal renal epithelium detected transporter associated with antigen processing (TAP)1 and tapasin deficiencies in 63 and 80% of the tumor lesions.	Formaldehyde	35-43	transporter 1, ATP binding cassette subfamily B member	Homo sapiens	110-163
12570834-7	2003	Another important way of demethylation generated formaldehyde production is given by microsomal cytochrome P-450 dependent oxidation of xenobiotics, such as various drugs prescribed by doctors.	Formaldehyde	49-61	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	96-112
12759105-2	2003	Intrinsic differences in the metabolism of CH(3)OH to formaldehyde (HCHO) and formic acid (HCOOH) by the enzymes alcohol dehydrogenase (ADH1), formaldehyde dehydrogenase (ADH3), and catalase may contribute to the observed species sensitivity.	Formaldehyde	54-66	alcohol dehydrogenase 1 (class I)	Mus musculus	136-140
12759105-2	2003	Intrinsic differences in the metabolism of CH(3)OH to formaldehyde (HCHO) and formic acid (HCOOH) by the enzymes alcohol dehydrogenase (ADH1), formaldehyde dehydrogenase (ADH3), and catalase may contribute to the observed species sensitivity.	Formaldehyde	54-66	alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide	Mus musculus	171-175
12686132-6	2003	The SSAO-catalyzed deamination of endogenous substrates, that is, methylamine and aminoacetone, led to production of toxic formaldehyde and methylglyoxal, hydrogen peroxide and ammonia, respectively.	Formaldehyde	123-135	amine oxidase, copper containing 3	Mus musculus	4-8
12686102-1	2003	This is a review of recent work on methanol dehydrogenase (MDH), a pyrroloquinoline quinone (PQQ)-containing enzyme catalysing the oxidation of methanol to formaldehyde in methylotrophic bacteria.	Formaldehyde	156-168	malate dehydrogenase 2	Homo sapiens	35-57
12629411-5	2003	E-cadherin expression was evaluated by immunostaining on formalin fixed, paraffin embedded tissue sections using anti E-cadherin murine monoclonal antibody, HECD1 and standard avidin-biotin immunoperoxidase complex technique.	Formaldehyde	57-65	cadherin 1	Homo sapiens	0-10
12686102-1	2003	This is a review of recent work on methanol dehydrogenase (MDH), a pyrroloquinoline quinone (PQQ)-containing enzyme catalysing the oxidation of methanol to formaldehyde in methylotrophic bacteria.	Formaldehyde	156-168	malate dehydrogenase 2	Homo sapiens	59-62
12697055-13	2003	CONCLUSION: We have established a simple fixation and immunofluorescence staining procedure that allows specific co-detection and precise sub-cellular localization of the PML nuclear bodies and the Ebola virus encoded proteins NP, VP35 and VP40 in formaldehyde treated cells.	Formaldehyde	248-260	PML nuclear body scaffold	Homo sapiens	171-174
12739843-5	2003	In this study, standard immunohistochemical methods were used to detect the presence of epidermal growth factor-receptor, transforming growth factor-alpha and nerve growth factor-beta in the human olfactory epithelium of different developmental stages (7 to 30 weeks) in formalin-fixed tissue specimens.	Formaldehyde	271-279	epidermal growth factor receptor	Homo sapiens	88-120
12852498-4	2003	METHOD OF STUDY: A monoclonal antibody (7B101D10), with specificity for the core region of GnRH-I was used to stain formalin-fixed tissue sections from adult male Sprague-Dawley rats, while a biotinylated GnRH-I sequence was used with avidin-labelled HRP to evaluate regions of GnRH-I binding.	Formaldehyde	116-124	gonadotropin releasing hormone 1	Homo sapiens	91-95
14533848-2	2003	We compared the effects of two AR procedures, enzyme digestion and microwave heating, on immunostaining of vimentin and desmin in formalin fixed, paraffin embedded tissues.	Formaldehyde	130-138	vimentin	Homo sapiens	107-115
14533848-2	2003	We compared the effects of two AR procedures, enzyme digestion and microwave heating, on immunostaining of vimentin and desmin in formalin fixed, paraffin embedded tissues.	Formaldehyde	130-138	desmin	Homo sapiens	120-126
14533848-3	2003	Our results showed that AR is necessary for vimentin and desmin immunostaining in tissues fixed in formalin for more than 48 h. With prolonged fixation times, microwave heating showed better results than enzyme digestion for AR.	Formaldehyde	99-107	desmin	Homo sapiens	57-63
12663147-3	2003	SUBJECTS: We examined TFF3 expression in formalin-fixed and paraffin-embedded intestinal tissues from 24 fetuses (gestational age [GA] 12-23 weeks) and 5 adults by immunohistochemical staining.	Formaldehyde	41-49	trefoil factor 3	Homo sapiens	22-26
12715168-5	2003	Her2/neu was immunohistochemically detected on sections from formalin-fixed, paraffin-embedded tissues using c-erbB-2/Her-2/neu oncoprotein Ab-17 monoclonal antibody (mAb).	Formaldehyde	61-69	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-8
12769341-2	2003	Polymerase chain reaction (PCR) has been used with increasing frequency to detect clonal rearrangements of the immunoglobulin heavy chain (IgH) in formaldehyde fixed, paraffin wax embedded tissues.	Formaldehyde	147-159	immunoglobulin heavy constant delta	Homo sapiens	111-137
12769341-2	2003	Polymerase chain reaction (PCR) has been used with increasing frequency to detect clonal rearrangements of the immunoglobulin heavy chain (IgH) in formaldehyde fixed, paraffin wax embedded tissues.	Formaldehyde	147-159	immunoglobulin heavy constant delta	Homo sapiens	139-142
12820338-0	2003	Her2/neu analysis in formalin-fixed, paraffin-embedded breast carcinomas: comparison of immunohistochemistry and multiparameter DNA flow cytometry.	Formaldehyde	21-29	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-4
12637466-3	2003	HER2 gene amplification (HER2_AMP) was evaluated by fluorescence in situ hybridization (FISH; Ventana Medical Systems HER-2/neu probe; Tucson, AZ), and HER2 protein overexpression (HER2_EXP) was evaluated by immunohistochemistry (IHC; Oncogene Science antibody Ab-3; Cambridge, MA) on parallel-cut formalin-fixed paraffin-embedded tissue sections.	Formaldehyde	298-306	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-4
12532420-5	2003	The mutation status of exons 5-8 of p53 was analyzed by denaturing high pressure liquid chromatography (DHPLC) in formalin-fixed, paraffin-embedded tumor sections, followed by direct sequencing of cases with aberrant chromatographic patterns.	Formaldehyde	114-122	tumor protein p53	Homo sapiens	36-39
12679565-6	2003	In addition, BV pretreatment into the Zusanli acupoint markedly inhibited spinal cord Fos expression induced by formalin injection.	Formaldehyde	112-120	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	86-89
12653580-3	2003	Methods.-Formalin-fixed, paraffin-embedded archival tissues were immunohistochemically stained via the labeled streptavidin-biotin method using antibodies against CD31 and S100 protein after heat-induced epitope retrieval.	Formaldehyde	9-17	S100 calcium binding protein A1	Homo sapiens	172-176
12610357-3	2003	Aims of our study were: 1) to determine the incidence of c-Kit expression in formalin-fixed paraffin-embedded tissue (FFPE) in pulmonary small cell carcinoma (SCC) and non small cell carcinoma (NSCC), pulmonary carcinoid, and malignant mesothelioma (MM); and 2) to test the feasibility of c-Kit determination using commercially available antibodies and routine immunohistochemical settings, comparing the performance of two commercially available antibodies, Dako and Santa Cruz.	Formaldehyde	77-85	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	57-62
12620371-0	2003	Inhibition of cyclic guanosine 5"-monophosphate-dependent protein kinase I (PKG-I) in lumbar spinal cord reduces formalin-induced hyperalgesia and PKG upregulation.	Formaldehyde	113-121	protein kinase cGMP-dependent 1	Rattus norvegicus	76-81
12579274-2	2003	By means of immunohistochemical methods, Bak expression was evaluated in formalin-fixed, paraffin-embedded diagnostic specimens from 83 patients with T1-T4 oral tongue squamous cell carcinomas (SCC).	Formaldehyde	73-81	BCL2 antagonist/killer 1	Homo sapiens	41-44
12536226-8	2003	Even after 1-month fixation in formalin, the hGLUT5 antibody stained microglia well.	Formaldehyde	31-39	solute carrier family 2 member 5	Homo sapiens	45-51
12620371-9	2003	Formalin treatment resulted in a rapid (within 1h), long-lasting (up to 96h) upregulation of PKG-I protein expression.	Formaldehyde	0-8	protein kinase cGMP-dependent 1	Rattus norvegicus	93-98
12593798-4	2003	Using mutant mice expressing a truncated form of the PSD-95 molecule, we show their failure to develop the NMDA receptor-dependent hyperalgesia and allodynia seen in the CCI model of neuropathic pain, but normal inflammatory nociceptive behavior following the injection of formalin.	Formaldehyde	273-281	discs large MAGUK scaffold protein 4	Mus musculus	53-59
12576455-2	2003	EXPERIMENTAL DESIGN: Expression of p27(Kip1) was assessed by immunohistochemistry on formalin-fixed, paraffin-embedded bone marrow biopsies.	Formaldehyde	85-93	zinc ribbon domain containing 2	Homo sapiens	35-38
12548159-6	2003	CDX-2 expression was evaluated in formalin-fixed, paraffin-embedded samples of normal adult human tissues (50 samples) and in 299 surgically resected carcinomas of different origins, including 125 non-lung adenocarcinomas, 117 primary lung tumors, 5 mesotheliomas, and 52 adenocarcinomas metastatic to the lung.	Formaldehyde	34-42	caudal type homeobox 2	Homo sapiens	0-5
12548163-1	2003	We tested 417 cases of formalin-fixed, paraffin-embedded normal or hyperplastic gynecologic tissues as well as neoplasms involving the gynecologic tract with a monoclonal antibody against CD10 (clone 56C6), with special emphasis on epithelial and epithelial-like structures and tumors.	Formaldehyde	23-31	membrane metalloendopeptidase	Homo sapiens	188-192
12576455-2	2003	EXPERIMENTAL DESIGN: Expression of p27(Kip1) was assessed by immunohistochemistry on formalin-fixed, paraffin-embedded bone marrow biopsies.	Formaldehyde	85-93	cyclin dependent kinase inhibitor 1B	Homo sapiens	39-43
12641788-1	2003	BACKGROUND: Antibodies to CD4, CD8, TIA-1, and CD56 are available which perform well in formalin-fixed and paraffin-embedded tissue.	Formaldehyde	88-96	CD4 molecule	Homo sapiens	26-29
12604204-1	2003	Human Class III alcohol dehydrogenase (ADH), also known as glutathione-dependent formaldehyde dehydrogenase plays an important role in the formaldehyde detoxification and reduction of the nitric oxide metabolite s-nitrosoglutathione (GSNO).	Formaldehyde	81-93	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	39-42
12604202-6	2003	This reductive breakdown directly interferes with the formaldehyde scavenging that has been proposed to be the physiological action of ADH3.	Formaldehyde	54-66	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	135-139
12641788-1	2003	BACKGROUND: Antibodies to CD4, CD8, TIA-1, and CD56 are available which perform well in formalin-fixed and paraffin-embedded tissue.	Formaldehyde	88-96	CD8a molecule	Homo sapiens	31-34
12641788-1	2003	BACKGROUND: Antibodies to CD4, CD8, TIA-1, and CD56 are available which perform well in formalin-fixed and paraffin-embedded tissue.	Formaldehyde	88-96	TIA1 cytotoxic granule associated RNA binding protein	Homo sapiens	36-41
12552081-1	2003	We established a quantitative real-time RT-PCR assay for the detection of chimeric BCR-ABL transcripts in archival formalin-fixed bone marrow trephines, both acrylate-embedded and paraffin-embedded.	Formaldehyde	115-123	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	83-90
12641788-1	2003	BACKGROUND: Antibodies to CD4, CD8, TIA-1, and CD56 are available which perform well in formalin-fixed and paraffin-embedded tissue.	Formaldehyde	88-96	neural cell adhesion molecule 1	Homo sapiens	47-51
12666714-8	2003	The expression of PCNA was evaluated in formalin-fixed, paraffin-embedded gingival samples using an immunoperoxidase technique and PC10 monoclonal antibody to PCNA.	Formaldehyde	40-48	proliferating cell nuclear antigen	Homo sapiens	18-22
12535787-0	2003	Formalin- or adjuvant-induced peripheral inflammation increases neurokinin-1 receptor gene expression in the mouse.	Formaldehyde	0-8	tachykinin 1	Mus musculus	64-76
12690634-4	2003	Matrilysin expression was immunohistochemically analyzed using formalin-fixed, paraffin-embedded specimens from 113 colorectal cancer patients who had undergone curative surgery.	Formaldehyde	63-71	matrix metallopeptidase 7	Homo sapiens	0-10
12507687-6	2003	However, 20 ng IL-6 injected intracisternally significantly increased the number of noxious behavioral responses produced by formalin.	Formaldehyde	125-133	interleukin 6	Rattus norvegicus	15-19
12507687-7	2003	The hyperalgesic action of intracisternal IL-6 in the orofacial formalin test was blocked by pretreatment with interleukin-1 (IL-1) receptor antagonist.	Formaldehyde	64-72	interleukin 6	Rattus norvegicus	42-46
12507687-7	2003	The hyperalgesic action of intracisternal IL-6 in the orofacial formalin test was blocked by pretreatment with interleukin-1 (IL-1) receptor antagonist.	Formaldehyde	64-72	interleukin 1 receptor antagonist	Rattus norvegicus	111-151
12535787-9	2003	Neurokinin-1 receptor mRNA levels in the ipsilateral dorsal spinal cords of mice were higher at 24 h after formalin injection or 4 days after CFA injection.	Formaldehyde	107-115	tachykinin 1	Mus musculus	0-12
12535787-10	2003	These results confirm that mice are hyperalgesic at late time points after formalin or adjuvant injection when NK-1 receptor gene expression is elevated in the dorsal spinal cord.	Formaldehyde	75-83	tachykinin receptor 1	Mus musculus	111-124
12518886-3	2003	PROCEDURE: Immunohistochemical analysis was used to detect lysozyme and lactoferrin in formalin-fixed, paraffin-embedded sections of the ocular glands.	Formaldehyde	87-95	lactotransferrin	Bos taurus	72-83
12532223-5	2003	Fifty-seven ACT (21 from children and 36 from adults) were evaluated for p53 expression by immunohistochemistry in formalin-fixed paraffin-embedded tissue and analyzed in terms of outcome.	Formaldehyde	115-123	tumor protein p53	Homo sapiens	73-76
15115285-6	2003	Hsp32 expression in formalin-fixed sections was assessed by avidin-biotin peroxidase immunohistochemistry using a polyclonal rabbit anti-Hsp32 as the primary antibody.	Formaldehyde	20-28	heme oxygenase 1	Homo sapiens	0-5
12971412-6	2003	The p53-dependent apoptosis related Bax proteins on formalin-fixed paraffin-embedded sections were stained by the avidin-biotin peroxidase complex method.	Formaldehyde	52-60	transformation related protein 53, pseudogene	Mus musculus	4-7
12971412-6	2003	The p53-dependent apoptosis related Bax proteins on formalin-fixed paraffin-embedded sections were stained by the avidin-biotin peroxidase complex method.	Formaldehyde	52-60	BCL2-associated X protein	Mus musculus	36-39
12538472-3	2003	EXPERIMENTAL DESIGN: p125(FAK) expression in formalin-fixed paraffin-embedded (FFPE) tissue was studied using immunohistochemical assays on 24 matched primary colorectal carcinomas and colorectal liver metastases as well as 18 different colorectal liver metastases using monoclonal anti-FAK 4.47.	Formaldehyde	45-53	SEC23 interacting protein	Homo sapiens	21-25
12538472-3	2003	EXPERIMENTAL DESIGN: p125(FAK) expression in formalin-fixed paraffin-embedded (FFPE) tissue was studied using immunohistochemical assays on 24 matched primary colorectal carcinomas and colorectal liver metastases as well as 18 different colorectal liver metastases using monoclonal anti-FAK 4.47.	Formaldehyde	45-53	protein tyrosine kinase 2	Homo sapiens	26-29
12527716-3	2003	Formalin-fixed paraffin sections were subjected to immunohistochemistry using anti-histidine decarboxylase antibody, and the sensitivity and specificity were compared with those of conventional neuroendocrine markers (CD56, chromogranin A, synaptophysin, and neuron-specific enolase).	Formaldehyde	0-8	histidine decarboxylase	Homo sapiens	83-106
12502750-1	2003	Although detection of the abnormal isoform of prion protein (PrP(sc)), the specific feature of transmissable spongiform encephalopathies (TSEs), has been previously demonstrated on formalin-fixed autolytic tissue, no samples with autolysis as severe as tested here (i.e., liquid state) have previously been tested.	Formaldehyde	181-189	PRP@	Bos taurus	61-64
12474230-9	2003	Immunofluorescence studies using four formalin-fixed, paraffin wax-embedded MCL tumours demonstrated cytoplasmic localization of STAT3, as opposed to the nuclear localization of the pSTAT3 species.	Formaldehyde	38-46	signal transducer and activator of transcription 3	Homo sapiens	129-134
23365501-3	2003	Expression of retinoblastoma gene protein product (pRB) was investigated in 118 formalin-fixed, paraffin-embedded cervical tissues by immunohistochemistry using commercially available antibody directed against RB protein.	Formaldehyde	80-88	RB transcriptional corepressor 1	Homo sapiens	14-28
23365501-3	2003	Expression of retinoblastoma gene protein product (pRB) was investigated in 118 formalin-fixed, paraffin-embedded cervical tissues by immunohistochemistry using commercially available antibody directed against RB protein.	Formaldehyde	80-88	RB transcriptional corepressor 1	Homo sapiens	51-54
12927220-11	2003	In rats treated with intra-CeA saline, WIN55,212-2 reduced the incidence of formalin-induced nociceptive behaviors and also reduced formalin-evoked c-fos expression in both superficial and deep laminae of the spinal cord dorsal horn.	Formaldehyde	132-140	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	148-153
12507695-9	2003	It also significantly attenuated the increase of Fos-Ir neurons observed in ipsilateral TNC laminae I-II after formalin injection.	Formaldehyde	111-119	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	49-52
12535941-3	2003	Formalin injection into one hindpaw caused a rapid transient upregulation of GLT-1 protein expression in the spinal cord which did not occur when rats were pretreated with morphine (10 mg/kg, i.p.)	Formaldehyde	0-8	solute carrier family 1 member 2	Rattus norvegicus	77-82
12535941-5	2003	Inhibition of GLT-1 by the transportable inhibitor trans-pyrrolidine-2,4-dicarboxylic acid resulted in a significant reduction of nociceptive behavior in the rat formalin assay.	Formaldehyde	162-170	solute carrier family 1 member 2	Rattus norvegicus	14-19
12837987-3	2003	Formalin-fixed paraffin-embedded tissues were immunohistochemically stained using anti-FHIT antibody.	Formaldehyde	0-8	fragile histidine triad diadenosine triphosphatase	Homo sapiens	87-91
12507695-10	2003	If the proper VNS effect on Fos-expression was subtracted, the reduction of formalin-induced nociceptor activation was 55%.	Formaldehyde	76-84	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	28-31
14521262-6	2003	As the diagnostic criteria for central neurocytoma include immunohistochemical and/or ultrastructural evidence for neuronal differentiation, NeuN as a sensitive and specific neuronal marker in formalin-fixed, paraffin-embedded tissues may greatly facilitate the differential diagnosis of central neurocytomas.	Formaldehyde	193-201	RNA binding fox-1 homolog 3	Homo sapiens	141-145
12486230-2	2002	AlkB is an alpha-ketoglutarate- and Fe(II)-dependent dioxygenase that oxidizes the relevant methyl groups and releases them as formaldehyde.	Formaldehyde	127-139	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	0-4
12817908-6	2003	METHODS: In this study a simple, precise and rapid flow cytometric assay was developed for the determination of von Willebrand factor activity, utilizing formalin-fixed platelets, fluorescein isothiocyanate-conjugated chicken anti-VWF antibodies (Fab-fragments) and phycoerythrine-conjugated anti-GPIIb/IIIa antibodies.	Formaldehyde	154-162	von Willebrand factor	Homo sapiens	112-133
12817908-10	2003	CONCLUSION: The accuracy and precision of the von Willebrand activity assay may be improved if a flow cytometer is utilized for measurement of the impact of ristocetin on binding of VWF to formalin-fixed platelets instead of measuring agglutination utilizing an aggregometer.	Formaldehyde	189-197	von Willebrand factor	Homo sapiens	182-185
12622775-4	2003	In formalin-fixed and paraffin-embedded human tissues, immunohistochemistry revealed all known expression sites of ACE, e.g. the epithelial brush borders of proximal kidney tubules, epithelial cells of epididymis, endothelial cells, activated macrophages as well as germ cells during spermatogenesis.	Formaldehyde	3-11	angiotensin I converting enzyme	Homo sapiens	115-118
12431774-5	2002	Formalin injections caused an increase in Fos expression as well as a release of SP, but not Endo2 from the ipsilateral side dorsal horn in L4-5.	Formaldehyde	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	42-45
12473599-10	2002	This study demonstrates for the first time the potential independent prognostic value of pRb2/p130 expression on formalin-fixed, paraffin-embedded sections from lung cancer patients.	Formaldehyde	113-121	proline rich protein BstNI subfamily 2	Homo sapiens	89-93
12473599-3	2002	We developed an immunohistochemical assay suitable for the detection of pRb2/p130, the last discovered member of the retinoblastoma gene family, on formalin-fixed and paraffin-embedded sections.	Formaldehyde	148-156	proline rich protein BstNI subfamily 2	Homo sapiens	72-76
12473599-3	2002	We developed an immunohistochemical assay suitable for the detection of pRb2/p130, the last discovered member of the retinoblastoma gene family, on formalin-fixed and paraffin-embedded sections.	Formaldehyde	148-156	RB transcriptional corepressor like 2	Homo sapiens	77-81
12473599-10	2002	This study demonstrates for the first time the potential independent prognostic value of pRb2/p130 expression on formalin-fixed, paraffin-embedded sections from lung cancer patients.	Formaldehyde	113-121	RB transcriptional corepressor like 2	Homo sapiens	94-98
12444143-4	2002	We demonstrated that extracellularly administered Vpr protein dose-dependently potentiated glucocorticoid-induced suppression of both mRNA expression and secretion of IL-12 subunit p35 and IL-12 holo-protein, but not IL-12 subunit p40 or IL-10, by human monocytes/macrophages stimulated with LPS or heat-killed, formalin-fixed Staphylococcus aureus (Cowan strain 1).	Formaldehyde	312-320	Vpr	Human immunodeficiency virus 1	50-53
12461058-5	2002	MATERIALS/METHODS: The expression of TSP-1 was studied in formalin fixed, paraffin wax embedded sections from 58 cases of pure DCIS, using a monoclonal antibody against TSP-1 and the avidin-biotin-diaminobenzidine immunoperoxidase detection system.	Formaldehyde	58-66	thrombospondin 1	Homo sapiens	37-42
12451619-3	2002	METHODS: p27(Kip1) protein was studied by immunohistochemistry in formalin-fixed tumor sections from 95 patients who underwent resection for gastric adenocarcinoma between 1991 and 1996.	Formaldehyde	66-74	zinc ribbon domain containing 2	Homo sapiens	9-12
12451619-3	2002	METHODS: p27(Kip1) protein was studied by immunohistochemistry in formalin-fixed tumor sections from 95 patients who underwent resection for gastric adenocarcinoma between 1991 and 1996.	Formaldehyde	66-74	cyclin dependent kinase inhibitor 1B	Homo sapiens	13-17
12464898-7	2002	Because MMP1 was the lowest or least expressed interface protein, MMP1 mRNA was quantitatively assessed from formalin-fixed paraffin-embedded tissue in selected cases with quantitative reverse transcription-polymerase chain reaction.	Formaldehyde	109-117	matrix metallopeptidase 1	Homo sapiens	66-70
12445746-1	2002	This study was performed to determine the frequency of expression loss of p16 and pRb; their relations with each other, tumour histology, tumour stage, nodal status, and survival in formalin fixed, paraffin embedded tumour tissues of patients with non-small-cell lung carcinoma (NSCLC).	Formaldehyde	182-190	cyclin dependent kinase inhibitor 2A	Homo sapiens	74-77
12453305-7	2002	Antibodies against Pmp6, 8, 10, 11 and 21 reacted with chlamydiae when infected cells were formalin fixed.	Formaldehyde	91-99	autotransporter domain-containing protein	Chlamydia pneumoniae CWL029	19-23
12570057-5	2002	Formaldehyde-fixed and alcohol-permeabilized cultured SCCKN cells were reacted with the anti-Egr-1 antibody using immunohistochemical methods.	Formaldehyde	0-12	early growth response 1	Homo sapiens	93-98
12564766-3	2002	FKBP12 immunoreactivity was associated with lipofuscin in formalin-fixed paraffin-embedded samples.	Formaldehyde	58-66	FKBP prolyl isomerase 1A pseudogene 4	Homo sapiens	0-6
12445785-5	2002	Binding of histone H1 was unaffected by prior crosslinking of protein and DNA in nucleosomes with formaldehyde.	Formaldehyde	98-110	H1.0 linker histone	Homo sapiens	11-21
12453305-10	2002	Due to their reaction in formalin fixation it is likely that Pmp6, 8, 10, 11 and 21 are surface exposed.	Formaldehyde	25-33	autotransporter domain-containing protein	Chlamydia pneumoniae CWL029	61-65
12391156-5	2002	By monitoring protein-DNA interactions in living cells using formaldehyde cross-linking and chromatin immunoprecipitation, we show that endogenous RB and AP-2 both bind to the same bcl-2 promoter sequence.	Formaldehyde	61-73	transcription factor AP-2, alpha	Mus musculus	154-158
12609061-2	2002	METHODS: Immunohistochemical method was used to detect the expression of BSAP in 33 samples of formalin-fixed, paraffin-embedded tissues of cHL.	Formaldehyde	95-103	paired box 5	Homo sapiens	73-77
12444553-6	2002	Immunohistochemical studies on formalin-fixed, paraffin-embedded tissues revealed hPTTG in 38.8% of B-cell lymphomas, 70.2% of T-cell lymphomas, and 73.1% of Hodgkin"s lymphomas.	Formaldehyde	31-39	PTTG1 regulator of sister chromatid separation, securin	Homo sapiens	82-87
12443735-1	2002	Cyclooxygenase-2 (COX-2) protein was detected immunohistochemically in formalin-fixed, paraffin wax-embedded lung tissues from 15 pigs with naturally occurring pleuropneumonia caused by Actinobacillus pleuropneumoniae.	Formaldehyde	71-79	prostaglandin-endoperoxide synthase 2	Sus scrofa	0-16
12443735-1	2002	Cyclooxygenase-2 (COX-2) protein was detected immunohistochemically in formalin-fixed, paraffin wax-embedded lung tissues from 15 pigs with naturally occurring pleuropneumonia caused by Actinobacillus pleuropneumoniae.	Formaldehyde	71-79	prostaglandin-endoperoxide synthase 2	Sus scrofa	18-23
12517053-4	2002	Formalin-fixed, paraffin-embedded tissues were used as template for nested polymerase chain reaction (PCR) detection of the mycobacterial hsp65 gene.	Formaldehyde	0-8	heat shock protein family D (Hsp60) member 1	Homo sapiens	138-143
12384231-3	2002	delivery of low doses of 8-bromo-cGMP (0.1-0.25 micromol) reduced nociceptive behavior and formalin-induced upregulation of PKG-I in the spinal cord.	Formaldehyde	91-99	protein kinase cGMP-dependent 1	Rattus norvegicus	124-129
12375051-5	2002	We, therefore, used a double differential polymerase chain reaction (ddPCR) for determination of the amplification/deletion profiles of erbB-1, -2, -3 and -4 genes in formalin-fixed, paraffin embedded (FFPE) specimens of human PHEOs.	Formaldehyde	167-175	epidermal growth factor receptor	Homo sapiens	136-157
12435456-4	2002	Pretreatment with the PACAP receptor antagonist PACAP(6-38) (0.5-2 microg) or PACAP-antiserum (1:500-2,000 dilution) dose-dependently attenuated the second phase, but not the first phase, of nociceptive responses to formalin.	Formaldehyde	216-224	adenylate cyclase activating polypeptide 1	Mus musculus	22-27
12435456-4	2002	Pretreatment with the PACAP receptor antagonist PACAP(6-38) (0.5-2 microg) or PACAP-antiserum (1:500-2,000 dilution) dose-dependently attenuated the second phase, but not the first phase, of nociceptive responses to formalin.	Formaldehyde	216-224	adenylate cyclase activating polypeptide 1	Mus musculus	48-53
12435456-4	2002	Pretreatment with the PACAP receptor antagonist PACAP(6-38) (0.5-2 microg) or PACAP-antiserum (1:500-2,000 dilution) dose-dependently attenuated the second phase, but not the first phase, of nociceptive responses to formalin.	Formaldehyde	216-224	adenylate cyclase activating polypeptide 1	Mus musculus	48-53
12435456-8	2002	Our results suggest that exogenously applied PACAP sensitizes the dorsal horn neurons to formalin stimulation, and facilitates NMDA receptor-mediated nociceptive response.	Formaldehyde	89-97	adenylate cyclase activating polypeptide 1	Mus musculus	45-50
21329602-2	2002	METHODS: Fhit protein expression was detected in 92 cases of formalin-fixed, paraffin-embedded human lung cancer by citrate-microwave-SP immunohistochemical method, of which 52 were non-small cell cancer (NSCLC) and 40 small cell cancer (SCLC).	Formaldehyde	61-69	fragile histidine triad diadenosine triphosphatase	Homo sapiens	9-13
12161283-2	2002	We show that formaldehyde induced the long-lasting expression of IL-4 and IFN-gamma mRNAs and the transient expression of IL-13 mRNA in mouse spleen and draining lymph nodes.	Formaldehyde	13-25	interleukin 4	Mus musculus	65-69
12161283-2	2002	We show that formaldehyde induced the long-lasting expression of IL-4 and IFN-gamma mRNAs and the transient expression of IL-13 mRNA in mouse spleen and draining lymph nodes.	Formaldehyde	13-25	interferon gamma	Mus musculus	74-83
12161283-2	2002	We show that formaldehyde induced the long-lasting expression of IL-4 and IFN-gamma mRNAs and the transient expression of IL-13 mRNA in mouse spleen and draining lymph nodes.	Formaldehyde	13-25	interleukin 13	Mus musculus	122-127
12161283-4	2002	Moreover, a weak contact hypersensitivity (CH) and the significant increases in IL-4 and IFN-gamma mRNAs were detected in the ear skin of formaldehyde-cutaneously exposed mice when rechallenged mouse ears.	Formaldehyde	138-150	interleukin 4	Mus musculus	80-84
12161283-4	2002	Moreover, a weak contact hypersensitivity (CH) and the significant increases in IL-4 and IFN-gamma mRNAs were detected in the ear skin of formaldehyde-cutaneously exposed mice when rechallenged mouse ears.	Formaldehyde	138-150	interferon gamma	Mus musculus	89-98
12351207-4	2002	The house keeping gene, beta-actin could be detected after fixing the retina either with 1% formalin or with 4% paraformaldehyde (PFA).	Formaldehyde	92-100	actin, beta	Rattus norvegicus	24-34
12167636-6	2002	Bmh1p and Bmh2p were found to associate in vivo with the yeast autonomous replication sequence ARS307, as assayed by formaldehyde cross-linking, followed by immunoprecipitation with anti-Bmh1p/Bmh2p antibody and conventional PCR.	Formaldehyde	117-129	14-3-3 family protein BMH1	Saccharomyces cerevisiae S288C	0-5
12151407-7	2002	Using formaldehyde cross-linked chromatin immunoprecipitation analysis, we found that Sp1 and Sp3 were associated with the endogenously repressed hTERT promoter in human fibroblasts.	Formaldehyde	6-18	Sp3 transcription factor	Homo sapiens	94-97
12151407-7	2002	Using formaldehyde cross-linked chromatin immunoprecipitation analysis, we found that Sp1 and Sp3 were associated with the endogenously repressed hTERT promoter in human fibroblasts.	Formaldehyde	6-18	telomerase reverse transcriptase	Homo sapiens	146-151
12167636-6	2002	Bmh1p and Bmh2p were found to associate in vivo with the yeast autonomous replication sequence ARS307, as assayed by formaldehyde cross-linking, followed by immunoprecipitation with anti-Bmh1p/Bmh2p antibody and conventional PCR.	Formaldehyde	117-129	14-3-3 family protein BMH2	Saccharomyces cerevisiae S288C	10-15
12368208-4	2002	To explore this possibility, we generated a digoxigenin-labeled riboprobe to pol mu mRNA and used the probe and in situ hybridization to examine the expression pattern of the pol mu gene in formalin-fixed, paraffin-embedded tissue sections of 37 B-NHLs.	Formaldehyde	190-198	DNA polymerase mu	Homo sapiens	175-181
12354802-5	2002	METHODS: Immunohistochemistry for MMP-13 was performed on formalin fixed, paraffin wax embedded sections of a large series of colorectal cancers (n = 249), all of which had uniform clinical and pathological information available.	Formaldehyde	58-66	matrix metallopeptidase 13	Homo sapiens	34-40
12385797-6	2002	Essential oil and formalin increased c-Fos in the paraventricular n. of the hypothalamus and in the dentate gyrus of the hippocampus.	Formaldehyde	18-26	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	37-42
12385797-7	2002	In the paraventricular n. of the thalamus formalin induced higher c-Fos than control in both sexes; when formalin treatment was carried out in presence of essential oil, c-Fos further increased in males, but remained at control levels in females.	Formaldehyde	42-50	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	66-71
12385797-7	2002	In the paraventricular n. of the thalamus formalin induced higher c-Fos than control in both sexes; when formalin treatment was carried out in presence of essential oil, c-Fos further increased in males, but remained at control levels in females.	Formaldehyde	105-113	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	170-175
12589922-8	2002	In addition, behavioural data indicate that antagonism of BDNF attenuates the second phase of hyperalgesia induced by formalin (in nerve growth factor-treated animals) and the thermal hyperalgesia induced by carageenan, suggesting that BDNF is involved in some aspects of central sensitisation in conditions of peripheral inflammation.	Formaldehyde	118-126	brain derived neurotrophic factor	Homo sapiens	58-62
12237880-1	2002	This study we presents a novel anti-occludin monoclonal antibody that can be used for formalin-fixed, paraffin-embedded tissue sections.	Formaldehyde	86-94	occludin	Homo sapiens	36-44
12379753-4	2002	Immunohistochemical staining with polyclonal rabbit IgG antibody to Fhit (ZR44, Zymed Laboratories) on formalin-fixed, paraffin-embedded tissues was used.	Formaldehyde	103-111	fragile histidine triad diadenosine triphosphatase	Homo sapiens	68-72
12237881-4	2002	This study describes an immunohistochemical method using BXP-21 to study ABCG2 expression in formalin-fixed, paraffin-embedded tissues.	Formaldehyde	93-101	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	73-78
12373444-5	2002	To do this, we assessed the effect of administering two PAF antagonists (BN 52021 and BN 50730, which are selective for cell surface and intracellular PAF binding sites, respectively) on formalin-induced nociceptive responses.	Formaldehyde	187-195	PCNA clamp associated factor	Rattus norvegicus	56-59
12373444-8	2002	CONCLUSIONS: These findings suggest a role for endogenous PAF in nociceptive transmission, especially for persistent pain such as that which occurs in the late phase of the formalin test.	Formaldehyde	173-181	PCNA clamp associated factor	Rattus norvegicus	58-61
12234259-5	2002	Using formalin-fixed lung tissues (n = 45), our results showed a significant difference in the percentage of Mphis stained for Bcl-2 or MAgs and Bax (P &lt; 0.0001).	Formaldehyde	6-14	BCL2-associated X protein	Mus musculus	145-148
12223232-3	2002	All drugs produced marked reductions of formalin-induced c-Fos and Zif/268 immunoreactivity in laminae I and II, and laminae V and VI in the rat lumbar spinal cord.	Formaldehyde	40-48	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	57-62
12223232-3	2002	All drugs produced marked reductions of formalin-induced c-Fos and Zif/268 immunoreactivity in laminae I and II, and laminae V and VI in the rat lumbar spinal cord.	Formaldehyde	40-48	early growth response 1	Rattus norvegicus	67-74
12208897-4	2002	METHODS: STK15 protein was visualized by immunohistochemistry in 205 formalin-fixed, paraffin-embedded human bladder tumors.	Formaldehyde	69-77	aurora kinase A	Homo sapiens	9-14
12204056-3	2002	DESIGN: beta-Catenin mutation in exon 3 was studied using polymerase chain reaction-single-strand conformation polymorphism (PCR-SSCP) and direct sequencing analysis in 30 formalin-fixed, paraffin-embedded liposarcomas.	Formaldehyde	172-180	catenin beta 1	Homo sapiens	8-20
12529921-4	2002	The students in TC 1 were exposed to formaldehyde levels ranging from less than 0.11 to 0.76 mg/m3 with an average at 0.25 mg/m3 during the 3-hour biology laboratory.	Formaldehyde	37-49	transcobalamin 1	Homo sapiens	16-20
12529921-5	2002	The students in TC 2 were exposed to higher concentrations of formaldehyde ranging from 0.26 to 1.2 mg/m3 with an average at 0.632 mg/m3.	Formaldehyde	62-74	transcobalamin 2	Homo sapiens	16-20
12135815-1	2002	BACKGROUND: Clinical and experimental studies suggest that increased activity of semicarbazide-sensitive amine oxidase (SSAO) and the production of cytotoxic metabolites (e.g., formaldehyde and hydrogen peroxide) may play an important role in the pathogenesis of atherosclerosis.	Formaldehyde	177-189	amine oxidase copper containing 2	Homo sapiens	81-118
12208773-10	2002	Intrathecal injection of orexin-A, but not orexin-B, decreased the sum of flinches in phases 1 and 2 in the formalin test and increased the hot plate latency.	Formaldehyde	108-116	hypocretin neuropeptide precursor	Rattus norvegicus	25-33
12204965-3	2002	Borreliacidal antibody was inhibited in cultures of lymph node cells obtained from C3H/HeJ mice vaccinated with formalin-inactivated B. burgdorferi and cultured with macrophages and B. burgdorferi and treated with recombinant gamma interferon (rIFN-gamma).	Formaldehyde	112-120	interferon gamma	Rattus norvegicus	244-254
12218210-3	2002	Formalin-fixed paraffin-embedded archival tissues from 10 IMTs and 125 other soft tissue tumors were stained for ALK1 and p80 with standard immunohistochemistry.	Formaldehyde	0-8	secretory leukocyte peptidase inhibitor	Homo sapiens	113-117
12392065-3	2002	Formalin-fixed and paraffin embedded specimens from normal skin, seborrheic keratoses, and squamous cell carcinomas were reacted with polyclonal antibodies against rat cathepsin L or cystatin a which cross-react to human cathepsin L and cystatin A, respectively.	Formaldehyde	0-8	cystatin A	Rattus norvegicus	183-193
12218216-7	2002	We found that prolonged formalin fixation (&gt;48 h) had a detrimental effect on quantitative RT polymerase chain reaction results that was most marked for MMP-1 and VEGF but less evident for p21 and EGFR.	Formaldehyde	24-32	matrix metallopeptidase 1	Homo sapiens	156-161
12218216-7	2002	We found that prolonged formalin fixation (&gt;48 h) had a detrimental effect on quantitative RT polymerase chain reaction results that was most marked for MMP-1 and VEGF but less evident for p21 and EGFR.	Formaldehyde	24-32	vascular endothelial growth factor A	Homo sapiens	166-170
12218216-7	2002	We found that prolonged formalin fixation (&gt;48 h) had a detrimental effect on quantitative RT polymerase chain reaction results that was most marked for MMP-1 and VEGF but less evident for p21 and EGFR.	Formaldehyde	24-32	H3 histone pseudogene 16	Homo sapiens	192-195
12218216-7	2002	We found that prolonged formalin fixation (&gt;48 h) had a detrimental effect on quantitative RT polymerase chain reaction results that was most marked for MMP-1 and VEGF but less evident for p21 and EGFR.	Formaldehyde	24-32	epidermal growth factor receptor	Homo sapiens	200-204
12163387-5	2002	The Cdh1 expression was investigated by immunostaining on archival formalin-fixed sections from 34 primary carcinomas and their accompanying normal epithelium and preinvasive and metastatic lesions.	Formaldehyde	67-75	cadherin 1	Homo sapiens	4-8
12237180-5	2002	P2X(3) receptor antisense oligonucleotide treatment significantly decreased nociceptive behaviors observed after injection of complete Freund"s adjuvant (CFA), formalin or alphabeta-methylene ATP into the rat"s hind paw.	Formaldehyde	160-168	purinergic receptor P2X, ligand-gated ion channel, 3	Mus musculus	0-6
12163362-7	2002	Furthermore, nested reverse transcriptase-polymerase chain reaction from formalin-fixed, paraffin-embedded tissue was performed and demonstrated that the Nkx2.5/Csx and eHAND gene product to be detected in all cases, and in three of six cases, respectively.	Formaldehyde	73-81	NK2 homeobox 5	Homo sapiens	154-160
12163362-7	2002	Furthermore, nested reverse transcriptase-polymerase chain reaction from formalin-fixed, paraffin-embedded tissue was performed and demonstrated that the Nkx2.5/Csx and eHAND gene product to be detected in all cases, and in three of six cases, respectively.	Formaldehyde	73-81	heart and neural crest derivatives expressed 1	Homo sapiens	169-174
12168062-6	2002	Formalin-fixed paraffin-embedded specimens were stained for VEGF-C and the correlation between the staining, its clinicopathological parameters and its prognostic power were analyzed statistically.	Formaldehyde	0-8	vascular endothelial growth factor C	Homo sapiens	60-66
12200115-3	2002	The removal of RDX was accompanied by the formation and accumulation of nitrite ion (NO(2)(-)), formaldehyde (HCHO), ammonium (NH(4)(+)), and nitrous oxide (N(2)O).	Formaldehyde	96-108	radixin	Homo sapiens	15-18
12127055-3	2002	The analysis of HER-2 is usually performed on formalin-fixed paraffin tissue sections obtained from surgery.	Formaldehyde	46-54	erb-b2 receptor tyrosine kinase 2	Homo sapiens	16-21
12354520-1	2002	The expression of mRNA encoding interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha) was studied, by reverse transcription-polymerase chain reaction and by in-situ hybridization with a non-radioactive digoxigenin-labelled probe, in formalin-fixed, paraffin wax-embedded lung tissue from pigs experimentally infected with a Korean isolate (North American genotype) of PRRSV.	Formaldehyde	253-261	interferon gamma	Sus scrofa	32-48
12101431-0	2002	Gene-gun particle with pro-opiomelanocortin cDNA produces analgesia against formalin-induced pain in rats.	Formaldehyde	76-84	proopiomelanocortin	Rattus norvegicus	23-43
12101431-4	2002	In this study, we developed a gene-gun method for the transfer of POMC cDNA in vivo, and investigated its therapeutic effect on inflammatory pain in a rat model of formalin-induced pain.	Formaldehyde	164-172	proopiomelanocortin	Rattus norvegicus	66-70
12101431-10	2002	However, rats which received POMC cDNA via gene-gun injection showed a significantly reduced response in phase 2 of the formalin test.	Formaldehyde	120-128	proopiomelanocortin	Rattus norvegicus	29-33
12101431-12	2002	The phase 2 response in animals treated with formalin and naloxone did not differ significantly from the control, implying that the analgesic effects of POMC cDNA particle injection in phase 2 of the formalin test are reversed by naloxone.	Formaldehyde	45-53	proopiomelanocortin	Rattus norvegicus	153-157
12101431-12	2002	The phase 2 response in animals treated with formalin and naloxone did not differ significantly from the control, implying that the analgesic effects of POMC cDNA particle injection in phase 2 of the formalin test are reversed by naloxone.	Formaldehyde	200-208	proopiomelanocortin	Rattus norvegicus	153-157
12200599-2	2002	METHODS: Immunohistochemical methodology was performed on formalin-fixed paraffin-embedded sections by using a monoclonal anti-HSP27 antibody.	Formaldehyde	58-66	heat shock protein family B (small) member 1	Homo sapiens	127-132
12354520-1	2002	The expression of mRNA encoding interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha) was studied, by reverse transcription-polymerase chain reaction and by in-situ hybridization with a non-radioactive digoxigenin-labelled probe, in formalin-fixed, paraffin wax-embedded lung tissue from pigs experimentally infected with a Korean isolate (North American genotype) of PRRSV.	Formaldehyde	253-261	tumor necrosis factor	Sus scrofa	95-104
12123792-3	2002	The purpose of this study was to characterize the sensitivity and specificity of different antibodies for detection of PR by immunohistochemistry (IHC) of formalin-fixed paraffin breast carcinoma sections.	Formaldehyde	155-163	progesterone receptor	Homo sapiens	119-121
12177241-3	2002	T-cadherin expression was observed in both normal epidermal basal cells and adnexal epithelial cells of formalin-fixed and paraffin-embedded tissue sections.	Formaldehyde	104-112	cadherin 13	Homo sapiens	0-10
12135782-5	2002	Both c-Fos and Zif/268 expressions following formalin injection were reduced by APV alone and APV+CNQX, but not by CNQX alone.	Formaldehyde	45-53	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	5-10
12135782-5	2002	Both c-Fos and Zif/268 expressions following formalin injection were reduced by APV alone and APV+CNQX, but not by CNQX alone.	Formaldehyde	45-53	early growth response 1	Rattus norvegicus	15-22
12135782-7	2002	These findings suggest that NMDA and AMPA/KA receptors are differentially involved in c-Fos and Zif/268 expression in the spinal dorsal horn following noxious thermal, formalin and mechanical stimulation.	Formaldehyde	168-176	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	86-91
12135782-7	2002	These findings suggest that NMDA and AMPA/KA receptors are differentially involved in c-Fos and Zif/268 expression in the spinal dorsal horn following noxious thermal, formalin and mechanical stimulation.	Formaldehyde	168-176	early growth response 1	Rattus norvegicus	96-103
12106677-0	2002	Adrenal medullary transplants reduce formalin-evoked c-fos expression in the rat spinal cord.	Formaldehyde	37-45	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	53-58
12106677-3	2002	In order to address this, expression of neural activity marker c-fos in response to intraplantar formalin was evaluated in animals with intrathecal adrenal medullary or control striated muscle transplants.	Formaldehyde	97-105	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	63-68
12123654-1	2002	The reaction of demethylation mediated by cytochrome P450 (CYP) leads to the equimolar production of demethylated metabolite and formaldehyde.	Formaldehyde	129-141	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	42-57
12123654-1	2002	The reaction of demethylation mediated by cytochrome P450 (CYP) leads to the equimolar production of demethylated metabolite and formaldehyde.	Formaldehyde	129-141	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	59-62
12110967-3	2002	Microinjections (1 microl) of histamine, serotonin (5-HT), nicotine, capsaicin, or formalin each elicited similar distributions of Fos-like immunoreactivity (FLI) in laminae I-II of the ipsilateral superficial dorsal horn, with little or no FLI in deeper laminae or contralaterally.	Formaldehyde	83-91	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	131-134
12150740-2	2002	METHODS: RT-PCR was used to amplify the SYT-SSX fusion transcripts using archival formalin-fixed paraffin-embedded tumor specimens from a series of 37 synovial sarcoma cases.	Formaldehyde	82-90	synaptotagmin 1	Homo sapiens	40-43
12150740-2	2002	METHODS: RT-PCR was used to amplify the SYT-SSX fusion transcripts using archival formalin-fixed paraffin-embedded tumor specimens from a series of 37 synovial sarcoma cases.	Formaldehyde	82-90	SSX family member 2	Homo sapiens	44-47
12196928-0	2002	Inadequate formalin fixation decreases reliability of p27 immunohistochemical staining: probing optimal fixation time using high-density tissue microarrays.	Formaldehyde	11-19	zinc ribbon domain containing 2	Homo sapiens	54-57
12196928-3	2002	We observed that with our standard formalin fixation in rapidly processed (same-day) radical prostatectomy specimens, there is often a gradient of p27(Kip1) staining in normal prostate epithelium, with more staining near the periphery and less staining toward the center of the sample.	Formaldehyde	35-43	zinc ribbon domain containing 2	Homo sapiens	147-150
12196928-3	2002	We observed that with our standard formalin fixation in rapidly processed (same-day) radical prostatectomy specimens, there is often a gradient of p27(Kip1) staining in normal prostate epithelium, with more staining near the periphery and less staining toward the center of the sample.	Formaldehyde	35-43	cyclin dependent kinase inhibitor 1B	Homo sapiens	151-155
12229934-2	2002	For that purpose, heating for 10 min by microwave (MW) up t o 100 degrees C in citrate buffer, pH 6.0, prior to immunostaining is often used to retrieve Bcl-2 antigens in archival formalin-fixed, paraffin-embedded tissue.	Formaldehyde	180-188	BCL2 apoptosis regulator	Homo sapiens	153-158
12118104-5	2002	Expression of galectin-3, a nonintegrin beta-galactosidase-binding lectin, has been reported to be significant in PLGA and decreased in ACC.Formalin-fixed paraffin-embedded tissue from 9 ACC and 14 PLGA were immunostained for c-kit and galectin-3.	Formaldehyde	140-148	galectin 3	Homo sapiens	14-24
12052441-2	2002	Formalin injection into the hindpaw of the rat induces the nocifensive flinching behavior and the expression of Fos-like immunoreactivity (Fos-LI) in the spinal cord.	Formaldehyde	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	112-115
12052441-2	2002	Formalin injection into the hindpaw of the rat induces the nocifensive flinching behavior and the expression of Fos-like immunoreactivity (Fos-LI) in the spinal cord.	Formaldehyde	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	139-142
12051635-5	2002	We evaluated calretinin reactivity in formalin-fixed, paraffin-embedded sections of 10 LCT, three SCT, five Leydig cell hyperplasia, two Sertoli cell adenomas, eight seminomatous tumors, five nonseminomatous germ cell tumors (mixed tumor), one adenomatoid tumor, and two normal testes using a standard immunohistochemical technique with a microwave-mediated epitope retrieval.	Formaldehyde	38-46	calbindin 2	Homo sapiens	13-23
14622771-0	2002	Genetic evidence for the correlation of deep dorsal horn Fos protein immunoreactivity with tonic formalin pain behavior.	Formaldehyde	97-105	FBJ osteosarcoma oncogene	Mus musculus	57-60
14622771-2	2002	Besides producing pain behavior, hind paw formalin injection induces the expression of the immediate-early gene, c-fos.	Formaldehyde	42-50	FBJ osteosarcoma oncogene	Mus musculus	113-118
14622771-7	2002	We observed a significant correlation among strains between licking behavior in the late phase (10 to 60 minutes) of the formalin test and Fos expression in laminae V-VI (but not laminae I-II) of the dorsal horn (r = 0.94).	Formaldehyde	121-129	FBJ osteosarcoma oncogene	Mus musculus	139-142
12140380-2	2002	We investigated the expression of CD10 in formalin-fixed, paraffin-embedded tissue specimens of 72 cutaneous melanomas (28 primary, 26 metastatic to the skin and 18 lymph node metastases).	Formaldehyde	42-50	membrane metalloendopeptidase	Homo sapiens	34-38
12046070-2	2002	METHODS: Two hundreds and forty-four formalin-fixed paraffin-embedded tumor samples of the patients with HCC receiving liver resection were detected for nuclear accumulation of p53.	Formaldehyde	37-45	tumor protein p53	Homo sapiens	177-180
12019329-8	2002	Formalin injection induced c-Fos in approximately 80% of projection neurons with the NK1 receptor and in 25-45% of those without it.	Formaldehyde	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	27-32
12019329-8	2002	Formalin injection induced c-Fos in approximately 80% of projection neurons with the NK1 receptor and in 25-45% of those without it.	Formaldehyde	0-8	tachykinin receptor 1	Rattus norvegicus	85-97
12080224-3	2002	The expression of E-cadherin and alpha-, beta-, and gamma-catenin was investigated using immunohistochemical technique with formalin-fixed, paraffin-embedded tissue specimens obtained from 108 patients who underwent surgery for early gastric cancer.	Formaldehyde	124-132	cadherin 1	Homo sapiens	18-28
12080224-3	2002	The expression of E-cadherin and alpha-, beta-, and gamma-catenin was investigated using immunohistochemical technique with formalin-fixed, paraffin-embedded tissue specimens obtained from 108 patients who underwent surgery for early gastric cancer.	Formaldehyde	124-132	catenin beta 1	Homo sapiens	33-65
12115486-3	2002	CT7-33 was effective in frozen as well as formalin-fixed, paraffin-embedded tissues, and immunohistochemistry/reverse transcriptase polymerase chain reaction (RT-PCR) co-typing demonstrated antibody specificity.	Formaldehyde	42-50	MAGE family member C1	Homo sapiens	0-3
12452072-3	2002	METHODS: Fhit protein expression in 66 cases of formalin-fixed, paraffin-embedded breast cancer composed of 6 in situ and 60 invasive ductal carcinoma were detected with citrate-microwave-Streptavidin-HRP(SP) immunohistochemical method, using rabbit antibody to human FHIT gene protein and relationships to invasion and lymphatic metastasis were analyzed.	Formaldehyde	48-56	fragile histidine triad diadenosine triphosphatase	Homo sapiens	9-13
12031901-2	2002	Recently, initial attack on Ala side-chains was shown to give alpha-carbon radicals (and hence backbone cleavage) and formaldehyde, via the formation and subsequent beta-scission, of C-3 alkoxyl radicals.	Formaldehyde	118-130	complement C3	Homo sapiens	183-186
12109783-0	2002	Expression of E-cadherin in prostate cancer in formalin-fixed, paraffin-embedded tissues: correlation with pathological features.	Formaldehyde	47-55	cadherin 1	Homo sapiens	14-24
12109783-2	2002	The present study aimed to assess the expression of E-cadherin in formalin-fixed and paraffin-embedded radical prostatectomy specimens and to compare its expression with the pathological stage and Gleason score.	Formaldehyde	66-74	cadherin 1	Homo sapiens	52-62
11992475-0	2002	Effects of somatosensory cortical stimulation on expression of c-Fos in rat medullary dorsal horn in response to formalin-induced noxious stimulation.	Formaldehyde	113-121	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	63-68
11992475-1	2002	We examined the effects of epidural electrical stimulation of primary (SI) and secondary (SII) somatosensory cortex on expression of c-Fos protein in rat medullary dorsal horn neurons (Vc; trigeminal nucleus caudalis) in response to formalin-induced noxious stimulation.	Formaldehyde	233-241	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	133-138
11992475-3	2002	SII stimulation at 1.0 mA immediately after injection of formalin, significantly decreased the number of Fos-positive cells in the right VcI/II by 32.4%.	Formaldehyde	57-65	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	105-108
11992475-5	2002	SII stimulation at 0.5 and 1.0 mA 2 hr after injection of formalin, significantly decreased the number of Fos-positive cells in the right VcI/II by 47.9% and 40.8%, but significantly increased the number of Fos-positive cells in the right VcIII/IV by 178.8% and 324.3%, respectively.	Formaldehyde	58-66	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	106-109
11976000-6	2002	RDX is sequentially degraded to nitroso-, dinitroso-, trinitroso- and hydroxylaminodinitroso-RDX before the triazine ring is presumably cleaved, forming methanol and formaldehyde as major end products.	Formaldehyde	166-178	radixin	Homo sapiens	0-3
12128098-4	2002	Transcripts of beta-actin and vimentin, assayed as controls, were detected at all stages, as well as Class III ADH (Adh-2) and Class 3 ALDH (Ahd-4), involved in the detoxification of formaldehyde and aromatic aldehydes, respectively.	Formaldehyde	183-195	actin, beta	Mus musculus	15-25
12128098-9	2002	ADH and ALDH enzyme systems may guard mouse preimplantation embryos against the toxic effects of industrial pollutants, such as formaldehyde and TCDD, as well as peroxidatic aldehydes generated during lipid peroxidation.	Formaldehyde	128-140	aldehyde dehydrogenase family 3, subfamily A1	Mus musculus	8-12
12128098-4	2002	Transcripts of beta-actin and vimentin, assayed as controls, were detected at all stages, as well as Class III ADH (Adh-2) and Class 3 ALDH (Ahd-4), involved in the detoxification of formaldehyde and aromatic aldehydes, respectively.	Formaldehyde	183-195	vimentin	Mus musculus	30-38
12128098-4	2002	Transcripts of beta-actin and vimentin, assayed as controls, were detected at all stages, as well as Class III ADH (Adh-2) and Class 3 ALDH (Ahd-4), involved in the detoxification of formaldehyde and aromatic aldehydes, respectively.	Formaldehyde	183-195	aldehyde dehydrogenase family 3, subfamily A1	Mus musculus	135-139
12128098-4	2002	Transcripts of beta-actin and vimentin, assayed as controls, were detected at all stages, as well as Class III ADH (Adh-2) and Class 3 ALDH (Ahd-4), involved in the detoxification of formaldehyde and aromatic aldehydes, respectively.	Formaldehyde	183-195	aldehyde dehydrogenase family 3, subfamily A1	Mus musculus	141-146
12575349-2	2002	METHODS: MMP1 and TIMP1 proteins were detected with the immunohistochemical method of avidin-biotin complex in formalin-fixed and routinely paraffin-embeded specimens of 46 patients.	Formaldehyde	111-119	matrix metallopeptidase 1	Homo sapiens	9-13
12575349-2	2002	METHODS: MMP1 and TIMP1 proteins were detected with the immunohistochemical method of avidin-biotin complex in formalin-fixed and routinely paraffin-embeded specimens of 46 patients.	Formaldehyde	111-119	TIMP metallopeptidase inhibitor 1	Homo sapiens	18-23
12007921-1	2002	We have evaluated the effects of nefopam on the spinal c-Fos protein expression in the model of acute (noxious heat) and persistent (intraplantar injection of formalin) nociception in the rat.	Formaldehyde	159-167	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	55-60
12007921-3	2002	formalin injection, c-Fos immunoreactive (c-Fos-IR) nuclei were preferentially located in the superficial (I-II) and deep (V-VI) laminae of the spinal dorsal horn of segments L4-L5, i.e. spinal areas containing numerous neurons responding exclusively, or not, to peripheral nociceptive stimuli.	Formaldehyde	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	42-47
12007921-4	2002	The doses of 15 and 30 mg/kg (s.c.) of nefopam had significant reducing effects on the formalin-evoked spinal c-Fos protein expression (36+/-14% and 47+/-9% reduction of the total number of c-Fos-IR nuclei per section, respectively, P&lt;0.05 for both).	Formaldehyde	87-95	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	110-115
12007921-4	2002	The doses of 15 and 30 mg/kg (s.c.) of nefopam had significant reducing effects on the formalin-evoked spinal c-Fos protein expression (36+/-14% and 47+/-9% reduction of the total number of c-Fos-IR nuclei per section, respectively, P&lt;0.05 for both).	Formaldehyde	87-95	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	190-195
26680852-5	2002	MATERIALS AND METHODS: Immunohistochemical expression of beta-catenin was studied in 7 normal livers, 33 hepatocellular carcinomas and 20 cholangiocarcinomas, that were formalin fixed and paraffin embedded.	Formaldehyde	169-177	catenin beta 1	Homo sapiens	57-69
12074836-8	2002	However, all the lines of Ca(v)2.2-/- mice exhibited reduced responses in the phase 2 of the formalin test, suggesting a suppression of inflammatory pain.	Formaldehyde	93-101	calcium channel, voltage-dependent, N type, alpha 1B subunit	Mus musculus	26-34
11888210-1	2002	A cDNA from Arabidopsis thaliana resembling S-formylglutathione hydrolase (SFGH), an enzyme with putative roles in formaldehyde detoxification in animals and microorganisms, has been cloned and expressed in Escherichia coli.	Formaldehyde	115-127	S-formylglutathione hydrolase	Arabidopsis thaliana	44-73
12049267-4	2002	Stool samples were examined by merthiolate iodine-formaldehyde concentration technique (MIF).	Formaldehyde	50-62	macrophage migration inhibitory factor	Homo sapiens	88-91
12419158-2	2002	METHODS: Detecting FHIT protein expression in 60 cases of formalin-fixed, paraffin-embedded colorectal carcinoma by citrate-microwave-SP immunohistochemical method, and analyzing its relationship to histological grade, Dukes" stage and 5-year survival rate.	Formaldehyde	58-66	fragile histidine triad diadenosine triphosphatase	Homo sapiens	19-23
11888210-1	2002	A cDNA from Arabidopsis thaliana resembling S-formylglutathione hydrolase (SFGH), an enzyme with putative roles in formaldehyde detoxification in animals and microorganisms, has been cloned and expressed in Escherichia coli.	Formaldehyde	115-127	S-formylglutathione hydrolase	Arabidopsis thaliana	75-79
11990392-4	2002	METHODS: Proliferating cell nuclear antigen was localised by immunoperoxidase on microwave oven pre-treated formalin-fixed, paraffin embedded sections using PC10 monoclonal antibody.	Formaldehyde	108-116	proliferating cell nuclear antigen	Homo sapiens	9-43
11774303-0	2002	Induction of c-fos and c-jun protooncogenes expression by formaldehyde-releasing and epoxy resin-based root-canal sealers in human osteoblastic cells.	Formaldehyde	58-70	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	13-18
11774303-0	2002	Induction of c-fos and c-jun protooncogenes expression by formaldehyde-releasing and epoxy resin-based root-canal sealers in human osteoblastic cells.	Formaldehyde	58-70	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	23-28
11774303-9	2002	Taken together, persistent induction of c-jun and c-fos protooncogenes by formaldehyde-releasing and epoxy resin-based root-canal sealers may be distributed systemically via apex to cause some unexpected adverse effects on human beings.	Formaldehyde	74-86	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	40-45
11774303-9	2002	Taken together, persistent induction of c-jun and c-fos protooncogenes by formaldehyde-releasing and epoxy resin-based root-canal sealers may be distributed systemically via apex to cause some unexpected adverse effects on human beings.	Formaldehyde	74-86	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	50-55
12014682-3	2002	This study was performed to examine the expression of u-PA in benign, borderline and malignant tumors of the ovary by immunohistochemical evaluation on formalin-fixed, paraffin-embedded specimens applying monoclonal antibody 3689 directed to the b-chain of u-PA.	Formaldehyde	152-160	plasminogen activator, urokinase	Homo sapiens	54-58
11793386-10	2002	Immunization of female NOD-mice with formalin-inactivated purified strain of coxsackievirus B4 (CBV-4-E2) induced an immune response that recognized the IA-2/IAR diabetogenic peptide.	Formaldehyde	37-45	protein tyrosine phosphatase receptor type N2	Homo sapiens	158-161
11884046-3	2002	METHODS: FasL expression was studied by immunohistochemistry in 170 formalin-fixed tissue sections representing the entire colorectal adenoma-carcinoma sequence.	Formaldehyde	68-76	Fas ligand	Homo sapiens	9-13
11895488-6	2002	CK7 immunostaining was performed on sections from formalin-fixed paraffin blocks.	Formaldehyde	50-58	keratin 7	Homo sapiens	0-3
11935299-3	2002	METHODS: Immunohistochemical methodology was performed on formalin-fixed paraffin-embedded sections by using a monoclonal anti-CBP antibody.	Formaldehyde	58-66	CREB binding protein	Homo sapiens	127-130
11922938-6	2002	Inhibition studies using brefeldin A and para-formaldehyde fixation revealed that GM-CSF found in the supernatant was not secreted, but due to shedding or proteolytic cleavage.	Formaldehyde	46-58	colony stimulating factor 2	Homo sapiens	82-88
11836618-1	2002	Overexpression and amplification of cyclin D1 were investigated by immunohistochemistry and differential polymerase chain reaction (dPCR) in 440 formalin-fixed primary breast carcinoma tissues.	Formaldehyde	145-153	cyclin D1	Homo sapiens	36-45
12474525-5	2002	differentially evaluate the effect of BCG immunotherapy in treated and untreated cohorts on the immunohistochemical expression of C-erbB-2 and VEGF in formalin-fixed paraffin-embedded sections of superficial and superficially invasive (Stage Ta-T1) transitional cell carcinoma of the bladder.	Formaldehyde	151-159	erb-b2 receptor tyrosine kinase 2	Homo sapiens	130-138
11930243-1	2002	In formalin pain model, the effect of propofol on Fos expression in the spinal cord was examined by means of c -fos oncogene immunohistochemistry and NADPH-d histochemistry.	Formaldehyde	3-11	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	50-53
11930243-2	2002	Fos-like immunoreactive (FLI) neurons were mainly found in the ipsilateral dorsal horn after injection of formalin, some of which were FLI/NOS double-labeled neurons.	Formaldehyde	106-114	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-3
11929495-8	2002	RESULTS: Formaldehyde increased the surface expressions of ICAM-1 and VCAM-1 on HMMECs.	Formaldehyde	9-21	intercellular adhesion molecule 1	Homo sapiens	59-65
11924705-0	2002	Immunohistochemical detection of an ABO-incompatible blood transfusion in formalin-fixed tissue.	Formaldehyde	74-82	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	36-39
11924705-4	2002	The way the incident happened remained unclear and the immunohistochemical detection of ABO incompatible erythrocytes in formaldehyde-fixed paraffin-embedded kidney, lung, liver and spleen tissue provided the only material evidence of the transfusion error.	Formaldehyde	121-133	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	88-91
11944999-1	2002	Inducible nitric oxide synthase (iNOS) protein was detected immunohistochemically in formalin-fixed, paraffin wax-embedded lung tissues from 10 natural cases of porcine pleuropneumonia.	Formaldehyde	85-93	LOC396821	Sus scrofa	0-31
11944999-1	2002	Inducible nitric oxide synthase (iNOS) protein was detected immunohistochemically in formalin-fixed, paraffin wax-embedded lung tissues from 10 natural cases of porcine pleuropneumonia.	Formaldehyde	85-93	LOC396821	Sus scrofa	33-37
11812713-0	2002	Peripheral amitriptyline suppresses formalin-induced Fos expression in the rat spinal cord.	Formaldehyde	36-44	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	53-56
11812713-1	2002	UNLABELLED: We examined the effects of systemically, spinally, and peripherally administered amitriptyline on formalin-induced Fos immunoreactivity in the lumbar spinal cord.	Formaldehyde	110-118	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	127-130
11812713-2	2002	Formalin (2.5%), injected subcutaneously into the rat hindpaw, increased Fos immunoreactivity in laminae I-II, III-IV, and V-VI of the dorsal L5 spinal cord.	Formaldehyde	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	73-76
11812713-4	2002	Amitriptyline coadministered with the formalin reduced both flinching and biting/licking behaviors, and significantly reduced Fos immunoreactivity, particularly in laminae I-II.	Formaldehyde	38-46	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	126-129
11812713-8	2002	Fos protein, an indicator of neuronal activity after noxious stimulation, is upregulated after formalin injection.	Formaldehyde	95-103	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-3
11929495-8	2002	RESULTS: Formaldehyde increased the surface expressions of ICAM-1 and VCAM-1 on HMMECs.	Formaldehyde	9-21	vascular cell adhesion molecule 1	Homo sapiens	70-76
11929495-9	2002	Formaldehyde also induced ICAM-1 and VCAM-1 mRNA.	Formaldehyde	0-12	intercellular adhesion molecule 1	Homo sapiens	26-32
11826189-3	2002	We have developed a real-time, reverse transcriptase-polymerase chain reaction (RT-PCR) multiplex assay for the identification of the primary fusion transcript types (SYT-SSX1 and SYT-SSX2) from formalin-fixed, paraffin-embedded (FFPE) tissues.	Formaldehyde	195-203	synaptotagmin 1	Homo sapiens	167-170
11929495-9	2002	Formaldehyde also induced ICAM-1 and VCAM-1 mRNA.	Formaldehyde	0-12	vascular cell adhesion molecule 1	Homo sapiens	37-43
11900883-5	2002	The decrease in formalin-induced pain behaviour following DRt lesioning is accompanied by a decrease of spinal noxious-evoked c-fos neuronal activation.	Formaldehyde	16-24	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	126-131
11805228-13	2002	Intrathecal pretreatment with antiserum against Leu-enkephalin, Met-enkephalin, or dynorphin A(1-17), but not beta-endorphin, enhanced only the second phase of nocifensive response to formalin.	Formaldehyde	184-192	prodynorphin	Mus musculus	48-62
11805228-13	2002	Intrathecal pretreatment with antiserum against Leu-enkephalin, Met-enkephalin, or dynorphin A(1-17), but not beta-endorphin, enhanced only the second phase of nocifensive response to formalin.	Formaldehyde	184-192	prodynorphin	Mus musculus	83-99
11805228-15	2002	In the spinal cord, Leu-enkephalin, and to a lesser extent, Met-enkephalin and dynorphin A(1-17) and mu- and delta(1)-opioid receptors, but not delta(2)- or kappa-opioid receptors, are involved in modulating the feedback inhibition of the second phase of formalin-induced nocifension.	Formaldehyde	255-263	prodynorphin	Mus musculus	20-34
11805228-15	2002	In the spinal cord, Leu-enkephalin, and to a lesser extent, Met-enkephalin and dynorphin A(1-17) and mu- and delta(1)-opioid receptors, but not delta(2)- or kappa-opioid receptors, are involved in modulating the feedback inhibition of the second phase of formalin-induced nocifension.	Formaldehyde	255-263	opioid receptor, delta 1	Mus musculus	101-134
11789735-0	2002	A formalin-fixed, paraffin-processed cell line standard for quality control of immunohistochemical assay of HER-2/neu expression in breast cancer.	Formaldehyde	2-10	erb-b2 receptor tyrosine kinase 2	Homo sapiens	108-117
11894632-3	2002	Immunohistochemical analysis with monoclonal antibodies against human CEA was performed in order to detect CEA in formalin fixed and paraffin embedded biopsy specimens of middle ear mucosa in chronic otitis media.	Formaldehyde	114-122	CEA cell adhesion molecule 3	Homo sapiens	70-73
11894632-3	2002	Immunohistochemical analysis with monoclonal antibodies against human CEA was performed in order to detect CEA in formalin fixed and paraffin embedded biopsy specimens of middle ear mucosa in chronic otitis media.	Formaldehyde	114-122	CEA cell adhesion molecule 3	Homo sapiens	107-110
11827319-7	2002	In full-scale wetlands, this suggests that either high plant productivity or low NO3- loading (high CH2O(App): N(Red)) may contribute to a high effective denitrification rate.	Formaldehyde	100-104	NBL1, DAN family BMP antagonist	Homo sapiens	81-84
11827319-8	2002	In contrast, low productivity or a high NO3- loading (low CH2O(App): N(Red)) would promote a lower denitrification rate.	Formaldehyde	58-62	NBL1, DAN family BMP antagonist	Homo sapiens	40-43
11821751-6	2002	METHODS: A monoclonal antibody directed against MICA and MICB was used to perform indirect immunohistochemistry on formalin fixed, paraffin embedded needle biopsies of kidney and pancreas allografts.	Formaldehyde	115-123	MHC class I polypeptide-related sequence A	Homo sapiens	48-52
11821751-6	2002	METHODS: A monoclonal antibody directed against MICA and MICB was used to perform indirect immunohistochemistry on formalin fixed, paraffin embedded needle biopsies of kidney and pancreas allografts.	Formaldehyde	115-123	MHC class I polypeptide-related sequence B	Homo sapiens	57-61
11790377-3	2002	ReN 1869 at 0.01-10 mg/kg is antinociceptive in tests of chemical nociception in rodents (formalin, capsaicin, phenyl quinone writhing) but not in thermal tests (hot plate and tail flick).	Formaldehyde	90-98	renin 1 structural	Mus musculus	0-3
12680645-5	2002	Multiplex RT-nPCR could be applied successfully to formalin-fixed, paraffin-embedded tissues for the detection and differentiation between North American and European genotypes of PRRSV.	Formaldehyde	51-59	nasopharyngeal carcinoma-related protein	Homo sapiens	13-17
12373534-6	2002	Formalin treatment did not affect NR1 splice variant expression but significantly increased and decreased the proportion of NR2A and NR2C, respectively.	Formaldehyde	0-8	glutamate ionotropic receptor NMDA type subunit 2A	Rattus norvegicus	124-128
12373534-6	2002	Formalin treatment did not affect NR1 splice variant expression but significantly increased and decreased the proportion of NR2A and NR2C, respectively.	Formaldehyde	0-8	glutamate ionotropic receptor NMDA type subunit 2C	Rattus norvegicus	133-137
11810694-7	2002	95:377-385], when cells were fixed in formaldehyde and permeabilized in detergent, fluorescently-labelled DNase I specifically stained G-actin and not F-actin.	Formaldehyde	38-50	deoxyribonuclease 1	Homo sapiens	106-113
12502190-2	2002	Immunohistochemical staining with monoclonal antibody against nm23 using LSAB2/HRP method on formalin-fixed, paraffin-embedded sections obtained from 32 tumors was performed.	Formaldehyde	93-101	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	62-66
12244572-7	2002	14-3-3sigma was found to associate in vivo with the monkey origins of DNA replication ors8 and ors12 in a cell cycle-dependent manner, as assayed by a chromatin immunoprecipitation (ChIP) assay that involved formaldehyde cross-linking, followed by immunoprecipitation with anti-14-3-3sigma antibody and quantitative PCR.	Formaldehyde	208-220	stratifin	Homo sapiens	0-11
12371530-0	2002	IgE-mediated urticaria from formaldehyde in a dental root canal compound.	Formaldehyde	28-40	immunoglobulin heavy constant epsilon	Homo sapiens	0-3
12371530-4	2002	Specific IgE to formaldehyde were positive.	Formaldehyde	16-28	immunoglobulin heavy constant epsilon	Homo sapiens	9-12
12095231-2	2002	Cross-linking experiments with formaldehyde suggested that the association reflected the in situ juxtapositioning of C/EBPbeta to nuclear matrix proteins in isolated nuclei.	Formaldehyde	31-43	CCAAT/enhancer binding protein beta	Rattus norvegicus	117-126
11795744-0	2002	Cooling decreases fos-immunoreactivity in the rat after formalin injection.	Formaldehyde	56-64	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	18-21
11795744-1	2002	The effects of cooling on inflammatory response after injection of formalin in rats were examined by counting Fos-labeled cells in the dorsal horn of the spinal cord and evaluating swelling.	Formaldehyde	67-75	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	110-113
12210765-4	2002	Immunofluorescent staining of the formaldehyde-fixed cells showed that eIF-5A was present in both the nucleus and cytoplasm.	Formaldehyde	34-46	eukaryotic translation initiation factor 5A	Homo sapiens	71-77
11934015-2	2002	Rabbit antibody to human TRT and SP immunohistochemical method were used to detect TRT expression in 24 cases of formalin-fixed, paraffin-embedded chronic human skin ulcer tissues induced by radiation, 5 cases of normal skin, 2 of burned skin, and 8 of cancer.	Formaldehyde	113-121	telomerase reverse transcriptase	Homo sapiens	83-86
12658752-2	2002	The expression of c-erbB2 was detected immunohistochemically by monoclonal antibody against the gene on the formalin-fixed paraffin sections of 21 hydatidiform moles, 21 invasive moles, 20 choriocarcinomas and 30 normal placentas.	Formaldehyde	108-116	erb-b2 receptor tyrosine kinase 2	Homo sapiens	18-25
11823069-7	2002	Formalin-induced oral responses following injections into the hindpaw and the expression of Fos in the superior colliculus were virtually absent until 10 days postnatal, despite the presence of Fos-like immunoreactivity in many other structures (e.g. spinal cord, parabrachial area, periaqueductal grey).	Formaldehyde	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	92-95
12815292-7	2002	The present report based on gated analysis of androgen receptor expression in nuclei isolated from archival formalin fixed/paraffin embedded breast tumors shows that receptor expression in aneuploid sub-populations is greater than that of the diploid cells.	Formaldehyde	108-116	androgen receptor	Homo sapiens	46-63
11784698-1	2002	A monoclonal antibody to excitatory amino acid transporter 1 (EAAT1) has been generated which robustly stains paraffin-embedded, formaldehyde-fixed as well as snap-frozen human post-mortem brain tissue.	Formaldehyde	129-141	solute carrier family 1 member 3	Homo sapiens	25-60
11823069-7	2002	Formalin-induced oral responses following injections into the hindpaw and the expression of Fos in the superior colliculus were virtually absent until 10 days postnatal, despite the presence of Fos-like immunoreactivity in many other structures (e.g. spinal cord, parabrachial area, periaqueductal grey).	Formaldehyde	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	194-197
11784698-1	2002	A monoclonal antibody to excitatory amino acid transporter 1 (EAAT1) has been generated which robustly stains paraffin-embedded, formaldehyde-fixed as well as snap-frozen human post-mortem brain tissue.	Formaldehyde	129-141	solute carrier family 1 member 3	Homo sapiens	62-67
12533967-4	2002	Formalin-fixed, paraffin embedded tissues were treated with ant-Bcl-2 antibody (Dako No M 0887).	Formaldehyde	0-8	solute carrier family 25 member 6	Homo sapiens	60-63
12065876-2	2002	METHODS: The expression of p53 and mdm2 was analyzed by an immunohistochemical assay in 80 formalin-fixed paraffin embedded primary tumour samples and related to the clinical response to 5-fluorouracil therapy and to the prognosis of the patients.	Formaldehyde	91-99	tumor protein p53	Homo sapiens	27-30
12065876-2	2002	METHODS: The expression of p53 and mdm2 was analyzed by an immunohistochemical assay in 80 formalin-fixed paraffin embedded primary tumour samples and related to the clinical response to 5-fluorouracil therapy and to the prognosis of the patients.	Formaldehyde	91-99	MDM2 proto-oncogene	Homo sapiens	35-39
12044461-5	2002	This was accompanied by a marked reduction in formalin-induced c-fos expression in the spinal cord.	Formaldehyde	46-54	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	63-68
12533967-4	2002	Formalin-fixed, paraffin embedded tissues were treated with ant-Bcl-2 antibody (Dako No M 0887).	Formaldehyde	0-8	BCL2 apoptosis regulator	Homo sapiens	64-69
11751513-3	2001	EXPERIMENTAL DESIGN: NF-kappaB activation was determined by immunohistochemical analysis of formalin-fixed, paraffin-embedded specimens from 64 gastric carcinoma patients.	Formaldehyde	92-100	nuclear factor kappa B subunit 1	Homo sapiens	21-30
12474536-4	2002	To investigate the role of these biomarkers in renal cancer, we analyzed the immunohistochemical distribution of CD44"s expression on formalin fixed paraffin embedded tissue from 67 renal cell carcinomas and correlated with clinicopathologic parameters as well as with p53 suppressor gene expression.	Formaldehyde	134-142	CD44 molecule (Indian blood group)	Homo sapiens	113-117
11743735-2	2001	Mild formaldehyde crosslinking of mouse neuroblastoma cells (N2a) that are susceptible to prion infection revealed the presence of PrP(C) in high molecular mass (HMM) protein complexes of 200 to 225 kDa.	Formaldehyde	5-17	prion protein	Mus musculus	131-137
12019470-9	2002	Formalin-fixed neoplastic tissues were immunohistochemically stained using rabbit antibody to human midregion PTHrP.	Formaldehyde	0-8	parathyroid hormone like hormone	Homo sapiens	110-115
11787820-1	2001	Standard immunohistochemical methods were used to detect the presence of vimentin, cytokeratin 8, cytokeratin 18, macrophages and Langerhans cells in the human tonsillar epithelium in formalin-fixed and frozen tissue specimens.	Formaldehyde	184-192	vimentin	Homo sapiens	73-81
11843932-7	2001	Expression of VEGF and VEGF-C was evaluated by immunohistochemistry of formalin-fixed, paraffin-embedded biopsy specimens.	Formaldehyde	71-79	vascular endothelial growth factor A	Homo sapiens	14-18
11843932-7	2001	Expression of VEGF and VEGF-C was evaluated by immunohistochemistry of formalin-fixed, paraffin-embedded biopsy specimens.	Formaldehyde	71-79	vascular endothelial growth factor C	Homo sapiens	23-29
11681935-1	2001	Geometries and energies of the reactants, complexes, and transition states for the reactions of lithium aluminum hydride with formaldehyde and cyclohexanone were obtained using ab initio and density functional (Becke3LYP/6-31G**) molecular orbital calculations.	Formaldehyde	126-138	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	217-220
11785641-8	2001	The limits of quantification (10sigma of the blank hydrazones) of formaldehyde and acetaldehyde were 2.2 and 1.2 ppb, respectively, for 21.9 L (0.15 L min(-1) for 146 min) of air sample volume.	Formaldehyde	66-78	CD59 molecule (CD59 blood group)	Homo sapiens	151-157
11740346-2	2001	ADH3 is expressed in all tissues examined and the enzyme is essential for formaldehyde scavenging.	Formaldehyde	74-86	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	0-4
11774187-0	2001	Hemochromatosis (HFE) gene sequence analysis of formalin-fixed, paraffin-embedded liver biopsy specimens.	Formaldehyde	48-56	homeostatic iron regulator	Homo sapiens	17-20
11774187-9	2001	CONCLUSION: When HH is clinically and/or histologically suspected, HFE gene sequencing of formalin-fixed, paraffin-embedded liver biopsy specimens is a rapid and cost-effective approach to genotypic diagnosis of HH.	Formaldehyde	90-98	homeostatic iron regulator	Homo sapiens	67-70
11731061-10	2001	Although morphine tolerance increased formalin-evoked persistent pain behavior and Fos-LI in wild-type mice, there was no difference between placebo- and morphine-treated mutant mice, suggesting that PKC gamma also contributes to chronic morphine-induced changes in nociceptive processing.	Formaldehyde	38-46	protein kinase C, gamma	Mus musculus	200-209
11698319-0	2001	Intrathecal pre-administration of fentanyl effectively suppresses formalin evoked c-Fos expression in spinal cord of rat.	Formaldehyde	66-74	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	82-87
11720027-6	2001	A modified avidin-biotin immunoperoxidase technique was used to stain the formalin-fixed tissue specimens for EGFr.	Formaldehyde	74-82	epidermal growth factor receptor	Equus caballus	110-114
11681843-0	2001	Blocking NMDA receptors in the hippocampal dentate gyrus with AP5 produces analgesia in the formalin pain test.	Formaldehyde	92-100	adaptor related protein complex 5 subunit beta 1	Homo sapiens	62-65
11681843-6	2001	Pain behaviors in both acute and tonic phases of the formalin test were significantly reduced by AP5 treatments.	Formaldehyde	53-61	adaptor related protein complex 5 subunit beta 1	Homo sapiens	97-100
11732796-1	2001	Immunostaining with monoclonal antibody (MoAb) hepatocyte paraffin 1 (Hep Par 1) and an MoAb to cytokeratin 7 (CK7) was performed on 105 formalin-fixed, paraffin-embedded canine hyperplastic and neoplastic hepatic lesions.	Formaldehyde	137-145	keratin, type II cytoskeletal 7	Canis lupus familiaris	111-114
11745874-4	2001	PROCEDURE: Ninety-seven WT were evaluated for p53 expression by immunohistochemistry in formalin-fixed paraffin-embedded tissue and correlated with outcome.	Formaldehyde	88-96	tumor protein p53	Homo sapiens	46-49
11723170-0	2001	Effects of selective COX-1 and -2 inhibition on formalin-evoked nociceptive behaviour and prostaglandin E(2) release in the spinal cord.	Formaldehyde	48-56	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	21-33
11723170-5	2001	This suggests that the formalin-evoked rapid PG release was primarily caused by COX-1 and was independent of COX-2.	Formaldehyde	23-31	prostaglandin-endoperoxide synthase 1	Homo sapiens	80-85
11723170-9	2001	The time course of COX-2 up-regulation suggests that the formalin-induced nociceptive response precedes COX-2 protein de novo synthesis and may therefore be unresponsive to COX-2 inhibition.	Formaldehyde	57-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
11706079-3	2001	We have developed an immunohistochemical assay that allows the evaluation of p14(ARF) expression in formalin-fixed, paraffin-embedded tissues, using commercially available antibodies.	Formaldehyde	100-108	cyclin dependent kinase inhibitor 2A	Homo sapiens	77-80
11711373-6	2001	METHODS: Using a rabbit polyclonal antibody against caveolin-1 and immunohistochemistry, we assessed caveolin-1 protein expression in 89 formalin-fixed, paraffin-embedded bladder tumor sections.	Formaldehyde	137-145	caveolin 1	Homo sapiens	101-111
11587806-8	2001	Formalin-treated RSV vaccination has been linked specifically to the induction of Th2 cells, which make IL-4 and IL-5 and induce a strong pulmonary eosinophilic response.	Formaldehyde	0-8	interleukin 4	Homo sapiens	104-108
11587806-8	2001	Formalin-treated RSV vaccination has been linked specifically to the induction of Th2 cells, which make IL-4 and IL-5 and induce a strong pulmonary eosinophilic response.	Formaldehyde	0-8	interleukin 5	Homo sapiens	113-117
11586093-2	2001	Formalin-fixed, paraffin-embedded tumor biopsies were stained for COX-2.	Formaldehyde	0-8	prostaglandin-endoperoxide synthase 2	Homo sapiens	66-71
11578232-1	2001	Formaldehyde oxime &lt;--&gt; nitrosomethane tautomerism, isomeric nitrone, and their common cations and anions are studied with Gaussian-2 theory using MP2(full)/6-31G geometries and with density functional theory using B3LYP/6-311+G**.	Formaldehyde	0-12	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	223-226
11550208-7	2001	METHODS: We performed immunohistochemistry against GSTA1 on formalin-fixed radical prostatectomies (n = 45).	Formaldehyde	60-68	glutathione S-transferase alpha 1	Homo sapiens	51-56
11820720-2	2001	Immunohistochemical study of the expression of c-erbB-2 was performed in formalin-fixed, paraffin-embedded sections from 82 gastric adenocarcinomas using polyclonal antibody.	Formaldehyde	73-81	erb-b2 receptor tyrosine kinase 2	Homo sapiens	47-55
11598155-5	2001	In the present study, we developed a tissue microdissection approach designed for use with formalin-fixed, paraffin-embedded specimens which is capable of detecting and characterizing the hOGG1 allelic loss using two highly informative, intragenic single nucleotide polymorphisms.	Formaldehyde	91-99	8-oxoguanine DNA glycosylase	Homo sapiens	188-193
11688845-7	2001	This article reviews data on the HER-2 gene and protein, discusses their association with clinical outcomes, and proposes a strategy for screening for HER-2 excess in formalin-fixed specimens of breast carcinoma.	Formaldehyde	167-175	erb-b2 receptor tyrosine kinase 2	Homo sapiens	151-156
12030802-10	2001	Our results indicate that, at the supraspinal level, CTX- and PTX-sensitive G-proteins appear to be involved in the modulation of antinociception induced by supraspinally administered beta-endorphin, but not morphine, in the formalin pain model.	Formaldehyde	225-233	pro-opiomelanocortin-alpha	Mus musculus	184-198
11494227-4	2001	Matrilysin expression was immunohistochemically analyzed using formalin-fixed, paraffin-embedded specimens from 113 colorectal cancer patients who had undergone curative surgery.	Formaldehyde	63-71	matrix metallopeptidase 7	Homo sapiens	0-10
11745225-2	2001	METHODS: Immunohistochemical staining for TGF-beta(1) and its receptors I and II was conducted on formalin fixed paraffin embedded archival cystectomy specimens of 80 patients with bladder TCC.	Formaldehyde	98-106	transforming growth factor beta 1	Homo sapiens	42-53
11560264-5	2001	Inducible nitric oxide synthase (iNOS) and nitrotyrosine (NT) were localized in formalin-fixed lung specimens by use of immunohistochemical staining, and nicotinamide adenine dinucleotide phosphate diaphorase (NADPHd) activity was localized in cryopreserved specimens by use of histochemical staining.	Formaldehyde	80-88	nitric oxide synthase 2	Equus caballus	0-31
11688576-3	2001	We therefore reviewed our last 1950 consultation cases with respect to cases in which CD31 immunostains were performed, to determine the frequency of CD31 expression in macrophages in formalin-fixed, paraffin-embedded tissue and how often the presence of these cells was a source of diagnostic confusion.	Formaldehyde	184-192	platelet and endothelial cell adhesion molecule 1	Homo sapiens	150-154
11688576-17	2001	CD31 may also be useful as a nonlysosomal marker of macrophages in formalin-fixed, paraffin-embedded sections.	Formaldehyde	67-75	platelet and endothelial cell adhesion molecule 1	Homo sapiens	0-4
11560264-5	2001	Inducible nitric oxide synthase (iNOS) and nitrotyrosine (NT) were localized in formalin-fixed lung specimens by use of immunohistochemical staining, and nicotinamide adenine dinucleotide phosphate diaphorase (NADPHd) activity was localized in cryopreserved specimens by use of histochemical staining.	Formaldehyde	80-88	nitric oxide synthase 2	Equus caballus	33-37
11566050-8	2001	Formalin decreased IFN-gamma in both Intact and GDX groups.	Formaldehyde	0-8	interferon gamma	Rattus norvegicus	19-28
11747605-1	2001	Crosslinkage of vimentin to DNA in mouse L929 cells by formaldehyde and isolation of SDS-stable DNA-vimentin complexes from normal L929 cells and mouse and human embryo fibroblasts indicated close spatial relations between these components in the intact cell.	Formaldehyde	55-67	vimentin	Mus musculus	16-24
11493379-12	2001	CONCLUSIONS: Our data have demonstrated that TCR gene rearrangement studies by PCR/DGGE are consistently positive regardless of tissue fixation (formalin-fixed, paraffin-embedded vs. fresh-frozen tissue) and biopsy site when the histologic degree of confidence is very high (diagnostic).	Formaldehyde	145-153	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	45-48
11567223-3	2001	ER-beta expression in CRC was investigated by immunohistochemical staining of sections of formalin-fixed, paraffin-embedded tissue from 55 CRC.	Formaldehyde	90-98	estrogen receptor 2	Homo sapiens	0-7
11511839-8	2001	CONCLUSION: In the diagnosis of MF, detection of CD7 deletion and monoclonal TCR rearrangements can be successfully performed in a cost-effective, timely fashion using routine formalin-fixed paraffin-embedded biopsy specimens.	Formaldehyde	176-184	CD7 molecule	Homo sapiens	49-52
11511839-8	2001	CONCLUSION: In the diagnosis of MF, detection of CD7 deletion and monoclonal TCR rearrangements can be successfully performed in a cost-effective, timely fashion using routine formalin-fixed paraffin-embedded biopsy specimens.	Formaldehyde	176-184	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	77-80
11561259-7	2001	The number of c-fos-positive cells increased as the formalin concentration increased.	Formaldehyde	52-60	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	14-19
11561259-8	2001	Halothane inhalation affected the results of both the behavior and the c-fos immunoreactivity, especially in the 10% formalin (3.7% formaldehyde) group.	Formaldehyde	117-125	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	71-76
11485988-6	2001	Using formaldehyde-based in vivo cross-linking, we show that the Gal4p activation domain recruits SAGA to the GAL1 UAS.	Formaldehyde	6-18	galactose-responsive transcription factor GAL4	Saccharomyces cerevisiae S288C	65-70
11493924-5	2001	To address this, we used formaldehyde-crosslinked chromatin immunoprecipitation (X-ChIP) to map TATA-binding protein (TBP), transcription initiation factor IIB (TFIIB) and IIF (TFIIF), and dHDAC1 (RPD3) across several Drosophila promoter regions.	Formaldehyde	25-37	TATA binding protein	Drosophila melanogaster	118-121
11496122-3	2001	The alpha(1B)-deficient mice showed a diminution in the phase 2 nociceptive responses more extensively than in the phase 1 nociceptive responses of the formalin test.	Formaldehyde	152-160	calcium channel, voltage-dependent, N type, alpha 1B subunit	Mus musculus	4-12
11549509-2	2001	METHODS: The expression of three negative regulators of the cell cycle, the retinoblastoma gene product (pRb), the WAF1/Cip1 gene product (p21), and the Kip1 gene product (p27), was investigated by immunohistochemistry on paraffin sections from 104 formalin-fixed clear cell carcinoma specimens and related to p53 overexpression, the clinicopathologic parameters, and survival.	Formaldehyde	249-257	interferon alpha inducible protein 27	Homo sapiens	172-175
11692211-5	2001	Immunohistochemical demonstration of HSP expression was performed using specific monoclonal antibodies after wet autoclave antigen retrieval on sections from either Carnoy-fixed (biopsies) or formalin-fixed (transplant nephrectomies) and paraffin-embedded tissue.	Formaldehyde	192-200	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	37-40
11531124-1	2001	The mechanism of the gas-phase reaction of *CH2OH+O2 to form CH2O+HO2* was studied theoretically by means of high-level quantum-chemical electronic structure methods (CASSCF and CCSD(T)).	Formaldehyde	44-48	heme oxygenase 2	Homo sapiens	66-69
11531124-6	2001	The observed non-Arrhenius behavior of the temperature dependence of the rate constant for the gas-phase oxidation of *CH2OH is ascribed to the combined effect of the initial barrier-free formation of the *OO-CH2OH adduct with a substantial energy release and the existence of a low-barrier and two high-barrier pathways for its decomposition into CH2O and HO2*.	Formaldehyde	119-123	heme oxygenase 2	Homo sapiens	357-360
11485988-6	2001	Using formaldehyde-based in vivo cross-linking, we show that the Gal4p activation domain recruits SAGA to the GAL1 UAS.	Formaldehyde	6-18	galactokinase	Saccharomyces cerevisiae S288C	110-114
11477119-13	2001	The selection of antibodies that recognise both PRB and PRA in formalin fixed tissue is essential for the accurate evaluation of PR positivity in clinical specimens.	Formaldehyde	63-71	S100 calcium binding protein A6	Homo sapiens	56-59
11712786-4	2001	In an effort to unravel molecular markers for non-responding nephroblastomas, we investigated by means of immunohistochemistty the expression of heat-shock protein 70 (HSP70) in formalin-fixed and paraffin-embedded tissue samples from 32 children afflicted with nephroblastoma.	Formaldehyde	178-186	heat shock protein family A (Hsp70) member 4	Homo sapiens	145-166
11511797-2	2001	The aim of this study was to examine the pharmacological effect of an intrathecal alpha-2 agonist and a cholinesterase inhibitor on the facilitated pain model induced by formalin injection and to determine the nature of drug interaction using an isobolographic analysis.	Formaldehyde	170-178	butyrylcholinesterase	Homo sapiens	104-118
14622822-1	2001	Inhibition of spinal Fos expression increases formalin-induced nociception and decreases spinal prodynorphin messenger ribonucleic acid (mRNA), suggesting that Fos modulates nociception by inducing dynorphin synthesis.	Formaldehyde	46-54	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	21-24
11461168-4	2001	Semicarbazide-sensitive amine oxidase (SSAO), located in outer membranes of vascular smooth muscles and endothelia, catalyzes deamination of methylamine-producing formaldehyde and hydrogen peroxide.	Formaldehyde	163-175	amine oxidase copper containing 2	Homo sapiens	0-37
11461168-4	2001	Semicarbazide-sensitive amine oxidase (SSAO), located in outer membranes of vascular smooth muscles and endothelia, catalyzes deamination of methylamine-producing formaldehyde and hydrogen peroxide.	Formaldehyde	163-175	amine oxidase copper containing 2	Homo sapiens	39-43
11461168-6	2001	SSAO-mediated generation of formaldehyde can induce protein (i.e. beta-amyloid) cross-linkage, deposition and subsequently plaque formation in the compartment adjacent to the cerebrovessels.	Formaldehyde	28-40	amine oxidase copper containing 2	Homo sapiens	0-4
11461168-7	2001	Formaldehyde may cause cytotoxicity, which induces inflammation and release of more SSAO, producing a cascade of toxic cycle.	Formaldehyde	0-12	amine oxidase copper containing 2	Homo sapiens	84-88
11496289-4	2001	METHODS: To determine p125FAK expression at the cellular level, we developed a monoclonal antibody that specifically detected FAK in formalin-fixed, paraffin-embedded tissue sections (5 microm) and analyzed the levels of FAK expression in human arteries and veins.	Formaldehyde	133-141	protein tyrosine kinase 2	Homo sapiens	126-129
11564215-2	2001	The present study was conducted to determine the pattern of immunohistochemical expression of E-cadherin and N-cadherin, using formalin-fixed, paraffin-embedded tissues from 97 primary gastric carcinomas, including 17 which were producing alpha-fetoprotein (AFP).	Formaldehyde	127-135	cadherin 1	Homo sapiens	94-104
11561755-1	2001	In order to confirm the presence of SYT-SSX fusion gene in epithelial and spindle cell components of synovial sarcoma, we performed a nested reverse transcriptase-polymerase chain reaction (RT-PCR) using microbeam microdissection of membrane-mounted native tissue (MOMeNT) technique applied on formalin-fixed, paraffin-embedded tumor specimens from two biphasic synovial sarcomas and a control tissue of adamantinoma.	Formaldehyde	294-302	synaptotagmin 1	Homo sapiens	36-39
11561755-1	2001	In order to confirm the presence of SYT-SSX fusion gene in epithelial and spindle cell components of synovial sarcoma, we performed a nested reverse transcriptase-polymerase chain reaction (RT-PCR) using microbeam microdissection of membrane-mounted native tissue (MOMeNT) technique applied on formalin-fixed, paraffin-embedded tumor specimens from two biphasic synovial sarcomas and a control tissue of adamantinoma.	Formaldehyde	294-302	SSX family member 2B	Homo sapiens	40-43
11464277-9	2001	A polyclonal antibody generated against PHF3 shows nuclear expression in most investigated formalin-fixed, paraffin embedded tissues.	Formaldehyde	91-99	PHD finger protein 3	Homo sapiens	40-44
11712786-4	2001	In an effort to unravel molecular markers for non-responding nephroblastomas, we investigated by means of immunohistochemistty the expression of heat-shock protein 70 (HSP70) in formalin-fixed and paraffin-embedded tissue samples from 32 children afflicted with nephroblastoma.	Formaldehyde	178-186	heat shock protein family A (Hsp70) member 4	Homo sapiens	168-173
11453994-1	2001	Methylobacterium dichloromethanicum DM4 is able to grow with dichloromethane as the sole carbon and energy source by using a dichloromethane dehalogenase/glutathione S-transferase (GST) for the conversion of dichloromethane to formaldehyde.	Formaldehyde	227-239	hematopoietic prostaglandin D synthase	Rattus norvegicus	154-179
11414470-8	2001	These data indicate that detection of active caspase-3 is a reliable marker for apoptosis in formalin-fixed human tissue, and that neuronal apoptosis in pontosubicular neuron necrosis is accompanied by a pronounced activation of caspase-3.	Formaldehyde	93-101	caspase 3	Homo sapiens	45-54
11382394-3	2001	S-II stimulation in combination with 7-nitro-indazole at a subeffective dose, 5 mg/kg, synergistically reduced the number of cells expressing c-Fos in response to intraplantar injection of formalin in the superficial regions (laminae I and II) of the L4 and L5 spinal dorsal horn in conscious rats, although each had no significant effect.	Formaldehyde	189-197	transcription elongation factor A1	Homo sapiens	0-4
11442661-2	2001	METHODS: Apoptosis was detected by using terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-biotin nick end labeling (TUNEL) technique in 34 formalin-fixed and paraffin-embedded specimens of renal pelvic and ureteral TCC.	Formaldehyde	148-156	DNA nucleotidylexotransferase	Homo sapiens	41-78
11442661-2	2001	METHODS: Apoptosis was detected by using terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-biotin nick end labeling (TUNEL) technique in 34 formalin-fixed and paraffin-embedded specimens of renal pelvic and ureteral TCC.	Formaldehyde	148-156	DNA nucleotidylexotransferase	Homo sapiens	80-83
11382394-3	2001	S-II stimulation in combination with 7-nitro-indazole at a subeffective dose, 5 mg/kg, synergistically reduced the number of cells expressing c-Fos in response to intraplantar injection of formalin in the superficial regions (laminae I and II) of the L4 and L5 spinal dorsal horn in conscious rats, although each had no significant effect.	Formaldehyde	189-197	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	142-147
11382394-4	2001	A similar synergism produced by S-II stimulation and 7-nitro-indazole was also confirmed in both the first and second phases in the formalin-induced behavioral nociception test.	Formaldehyde	132-140	transcription elongation factor A1	Homo sapiens	32-36
11337360-1	2001	We have developed a protocol for degenerate oligonucleotide-primed-polymerase chain reaction-based array comparative genomic hybridization (array CGH) that, when combined with a laser microdissection technique, allows the analysis of cancer cell populations isolated from routine, formalin-fixed, paraffin-embedded tissue samples.	Formaldehyde	281-289	hypertrichosis 2 (generalised, congenital)	Homo sapiens	146-149
11408047-4	2001	Pretreatment of mice with antiserum against beta-endorphin enhanced the second phase, but not the first phase of the nocifensive responses to formalin.	Formaldehyde	142-150	pro-opiomelanocortin-alpha	Mus musculus	44-58
11408047-5	2001	Pretreatment with antiserum against [Leu5]enkephalin also caused a small but statistically significant enhancement of the second phase, but not the first phase of nocifensive responses to formalin.	Formaldehyde	188-196	tripartite motif-containing 13	Mus musculus	37-41
11408047-7	2001	Our results indicate that beta-endorphinergic, and to a lesser extent, [Leu5]enkephalinergic systems are activated at the supraspinal sites to attenuate the nocifensive responses to formalin stimulation.	Formaldehyde	182-190	tripartite motif-containing 13	Mus musculus	72-76
11356891-5	2001	In a dose-dependent manner, intraplantar injection of the SRIF receptor antagonist cyclo-somatostatin (c-SOM) results in nociceptive behaviors in normal animals and enhancement of nociceptive behaviors in formalin-injected animals, and these actions can be blocked when c-SOM is coapplied with three different SRIF agonists.	Formaldehyde	205-213	somatostatin	Homo sapiens	89-101
11388404-3	2001	This suggested that paw formalin injection induced nociceptin release in the spinal cord and the supraspinal brain sites, that this endogenously released nociceptin produced an analgesic effect and that J-113397 antagonized this analgesic effect of nociceptin and produced an algesic effect in the rat formalin test.	Formaldehyde	24-32	prepronociceptin	Rattus norvegicus	51-61
11388404-3	2001	This suggested that paw formalin injection induced nociceptin release in the spinal cord and the supraspinal brain sites, that this endogenously released nociceptin produced an analgesic effect and that J-113397 antagonized this analgesic effect of nociceptin and produced an algesic effect in the rat formalin test.	Formaldehyde	24-32	prepronociceptin	Rattus norvegicus	154-164
11388404-3	2001	This suggested that paw formalin injection induced nociceptin release in the spinal cord and the supraspinal brain sites, that this endogenously released nociceptin produced an analgesic effect and that J-113397 antagonized this analgesic effect of nociceptin and produced an algesic effect in the rat formalin test.	Formaldehyde	24-32	prepronociceptin	Rattus norvegicus	154-164
11388404-3	2001	This suggested that paw formalin injection induced nociceptin release in the spinal cord and the supraspinal brain sites, that this endogenously released nociceptin produced an analgesic effect and that J-113397 antagonized this analgesic effect of nociceptin and produced an algesic effect in the rat formalin test.	Formaldehyde	302-310	prepronociceptin	Rattus norvegicus	154-164
11388404-3	2001	This suggested that paw formalin injection induced nociceptin release in the spinal cord and the supraspinal brain sites, that this endogenously released nociceptin produced an analgesic effect and that J-113397 antagonized this analgesic effect of nociceptin and produced an algesic effect in the rat formalin test.	Formaldehyde	302-310	prepronociceptin	Rattus norvegicus	154-164
11468695-5	2001	METHODS AND RESULTS: We sought to determine whether 25 archival, formalin-fixed, paraffin-embedded PC samples had a modified CYP1A1 gene profile at exon 7 using allele-specific PCR amplification.	Formaldehyde	65-73	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	125-131
11388404-1	2001	The authors investigated the role of endogenously released nociceptin (also known as orphanin FQ) spinal and supraspinal nociceptive transmission during the rat formalin test by examining the effect of intrathecal and intracerebroventricular injection of J-113397, a non-peptidyl ORL1 receptor selective antagonist.	Formaldehyde	161-169	prepronociceptin	Rattus norvegicus	85-96
11358811-3	2001	We identified mutations in exons 5-8 of p53 using DNA extracted from formalin-fixed paraffin-embedded tissue blocks from 146 whites and 26 non-whites with astrocytic glioma by PCR-single-strand conformation polymorphism and direct sequencing.	Formaldehyde	69-77	tumor protein p53	Homo sapiens	40-43
11387027-4	2001	Based on the established role of alcohol dehydrogenase 3 (ADH3), also known as glutathione-dependent formaldehyde dehydrogenase, as the primary enzyme catalysing the detoxification of formaldehyde, the aim of this study was to investigate the expression of ADH3 in organotypic epithelia regenerated with normal (NOK), immortalised (SVpgC2a) and malignant (SqCC/Y1) human oral keratinocytes.	Formaldehyde	101-113	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	33-56
11387027-4	2001	Based on the established role of alcohol dehydrogenase 3 (ADH3), also known as glutathione-dependent formaldehyde dehydrogenase, as the primary enzyme catalysing the detoxification of formaldehyde, the aim of this study was to investigate the expression of ADH3 in organotypic epithelia regenerated with normal (NOK), immortalised (SVpgC2a) and malignant (SqCC/Y1) human oral keratinocytes.	Formaldehyde	101-113	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	58-62
11345832-1	2001	Hepatocyte paraffin 1 (Hep Par 1) is a monoclonal antibody considered almost specific for normal and neoplastic hepatocytes, that can be used on formalin-fixed paraffin-embedded tissues.	Formaldehyde	145-153	Prader Willi/Angelman region RNA 1	Homo sapiens	27-32
11519863-4	2001	Therefore, we developed an immunohistochemical method for ODC determination which can be applied to formalin-fixed, paraffin-embedded tissue sections.	Formaldehyde	100-108	ornithine decarboxylase 1	Homo sapiens	58-61
11359391-3	2001	METHODS: IL-15 mRNA and protein expression were examined by in situ hybridization and immunohistochemistry, respectively, on formalin-fixed, paraffin-embedded biopsies of normal human skin, atopic dermatitis, psoriasis, parapsoriasis and CTCL.	Formaldehyde	125-133	interleukin 15	Homo sapiens	9-14
11422798-6	2001	The SYT-SSX2 fusion transcripts were detected by a reverse transcription-polymerase chain reaction (RT-PCR) using RNA extracted from formalin-fixed, paraffin-embedded tissue.	Formaldehyde	133-141	synaptotagmin 1	Homo sapiens	4-7
11335900-7	2001	The expression of Skp2 also was examined by immunohistochemistry using formalin fixed, paraffin embedded tissue sections from the same cases.	Formaldehyde	71-79	S-phase kinase associated protein 2	Homo sapiens	18-22
11313463-3	2001	p53-DNA complexes were cross-linked in vivo by treating the cells with formaldehyde and processed by chromatin immunoprecipitation-PCR.	Formaldehyde	71-83	tumor protein p53	Homo sapiens	0-3
11358058-2	2001	Having refined a PCR technique for the detection of immunoglobulin heavy chain (IgH) gene rearrangement in both fresh and formalin-fixed, paraffin-embedded skin samples, we undertook to define the role of this assay in the diagnostic setting.	Formaldehyde	122-130	immunoglobulin heavy constant delta	Homo sapiens	80-83
11422798-6	2001	The SYT-SSX2 fusion transcripts were detected by a reverse transcription-polymerase chain reaction (RT-PCR) using RNA extracted from formalin-fixed, paraffin-embedded tissue.	Formaldehyde	133-141	SSX family member 2	Homo sapiens	8-12
11306434-7	2001	Immunohistochemical studies on formalin-fixed, paraffin-embedded sections of surgical and autopsy material from lungs of individuals with LAM showed diffuse NO synthase III (NOSIII) expression in the lesional smooth muscle of LAM similar to that in the vascular endothelium.	Formaldehyde	31-39	nitric oxide synthase 3	Homo sapiens	157-172
11306018-2	2001	We determined whether repeated formaldehyde (Form) exposure would alter corticosterone (CORT) levels in a rat model of MCS.	Formaldehyde	31-43	cortistatin	Rattus norvegicus	88-92
11474546-4	2001	The expression of the nNOS gene in the PVN was significantly increased 2 and 6 h after s.c. injection of formalin in comparison with that in untreated and saline injected rats.	Formaldehyde	105-113	nitric oxide synthase 1	Rattus norvegicus	22-26
11474546-6	2001	The AVP hnRNA in the PVN and SON was also significantly increased 15, 30 min and 2 h after s.c. injection of formalin, though AVP mRNA did not change at any time points that we studied.	Formaldehyde	109-117	arginine vasopressin	Rattus norvegicus	4-7
11474546-7	2001	Plasma concentration of AVP was significantly increased 15 min after s.c. injection of formalin.	Formaldehyde	87-95	arginine vasopressin	Rattus norvegicus	24-27
11290539-2	2001	In this study, we have evaluated neurofibromatosis type 2 (NF2) gene alterations in eight PNTs using archival formaldehyde-fixed, paraffin-embedded tissue.	Formaldehyde	110-122	NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor	Homo sapiens	59-62
11294993-4	2001	We analyzed formalin-fixed, paraffin-embedded specimens of different malignancies with pulmonary location for the expression of SP-A by the use of PE-10 with other antibodies against additional epitopes such as the thyroid transcription factor-1.	Formaldehyde	12-20	surfactant protein A1	Homo sapiens	128-132
11306434-7	2001	Immunohistochemical studies on formalin-fixed, paraffin-embedded sections of surgical and autopsy material from lungs of individuals with LAM showed diffuse NO synthase III (NOSIII) expression in the lesional smooth muscle of LAM similar to that in the vascular endothelium.	Formaldehyde	31-39	nitric oxide synthase 3	Homo sapiens	174-180
11963850-1	2001	A formaldehyde-tolerant bacterium designated as a DM-2 strain was used to biodegrade formaldehyde.	Formaldehyde	2-14	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	50-54
11963850-1	2001	A formaldehyde-tolerant bacterium designated as a DM-2 strain was used to biodegrade formaldehyde.	Formaldehyde	85-97	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	50-54
11963850-3	2001	The rate of formaldehyde degradation achieved in this study was 45 ppm/h when the DM-2 culture"s optical density at 660 nm was 1.2.	Formaldehyde	12-24	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	82-86
11315621-3	2001	hBD-2 expression was studied using immunohistochemistry and in situ hybridization on formalin-fixed, paraffin-embedded tissue sections from 30 cases of squamous cell carcinoma and 6 cases of leukoplakia.	Formaldehyde	85-93	defensin beta 4A	Homo sapiens	0-5
11298532-5	2001	METHODS: We examined changes in the expression of MDR-1 and MRP genes at the mRNA level before and after chemotherapy by reverse transcription-polymerase chain reaction (RT-PCR) analysis using formalin-fixed, paraffin-embedded sections of 18 specimens taken from eight melanoma patients.	Formaldehyde	193-201	ATP binding cassette subfamily B member 1	Homo sapiens	50-55
11298532-5	2001	METHODS: We examined changes in the expression of MDR-1 and MRP genes at the mRNA level before and after chemotherapy by reverse transcription-polymerase chain reaction (RT-PCR) analysis using formalin-fixed, paraffin-embedded sections of 18 specimens taken from eight melanoma patients.	Formaldehyde	193-201	ATP binding cassette subfamily C member 1	Homo sapiens	60-63
11304845-9	2001	Immunohistochemistry for IL-10 was performed on formalin fixed tissues using a combination of microwave antigen retrieval and the indirect avidin-biotin technique.	Formaldehyde	48-56	interleukin 10	Homo sapiens	25-30
11266660-1	2001	Semicarbazide-sensitive amine oxidase (SSAO) catalyzes the deamination of methylamine and aminoacetone to produce toxic aldehydes, i.e. formaldehyde and methylglyoxal, as well as hydrogen peroxide and ammonia.	Formaldehyde	136-148	amine oxidase copper containing 2	Homo sapiens	0-37
11266660-1	2001	Semicarbazide-sensitive amine oxidase (SSAO) catalyzes the deamination of methylamine and aminoacetone to produce toxic aldehydes, i.e. formaldehyde and methylglyoxal, as well as hydrogen peroxide and ammonia.	Formaldehyde	136-148	amine oxidase copper containing 2	Homo sapiens	39-43
11172934-3	2001	The best procedure for the demonstration of caspase-3 requires formalin fixation, followed by Carnoy fixation, with microwave irradiation.	Formaldehyde	63-71	caspase 3	Homo sapiens	44-53
11242790-4	2001	We studied immunohistochemical expression of NTRK3, and conducted a reverse transcription-polymerase chain reaction (RT-PCR) assay to detect the ETV6-NTRK3 fusion transcripts using archival formalin-fixed paraffin-embedded tissues from 10 CIFSs.	Formaldehyde	190-198	ETS variant transcription factor 6	Homo sapiens	145-149
11242790-11	2001	These results show the diagnostic usefulness of RT-PCR methods to detect ETV6-NTRK3 fusion transcripts in archival formalin-fixed paraffin-embedded tissue and the important role of NTRK3 in the development of CIFS, despite its being a protein of little importance in differential diagnosis.	Formaldehyde	115-123	ETS variant transcription factor 6	Homo sapiens	73-77
11242790-11	2001	These results show the diagnostic usefulness of RT-PCR methods to detect ETV6-NTRK3 fusion transcripts in archival formalin-fixed paraffin-embedded tissue and the important role of NTRK3 in the development of CIFS, despite its being a protein of little importance in differential diagnosis.	Formaldehyde	115-123	neurotrophic receptor tyrosine kinase 3	Homo sapiens	78-83
11277419-5	2001	Therefore, the authors wondered if nuclear and mitotic Bcl-2 immunoreactivity could be irreversibly reduced by certain fixation procedures, including formaldehyde fixation.	Formaldehyde	150-162	BCL2 apoptosis regulator	Homo sapiens	55-60
11277419-7	2001	Whereas nuclear and mitotic immunoreactivity for Bcl-2 was clearly present after formaldehyde and methanol fixation, it was completely absent in cells fixed in acetone, methanol, or formaldehyde alone.	Formaldehyde	81-93	BCL2 apoptosis regulator	Homo sapiens	49-54
11277419-7	2001	Whereas nuclear and mitotic immunoreactivity for Bcl-2 was clearly present after formaldehyde and methanol fixation, it was completely absent in cells fixed in acetone, methanol, or formaldehyde alone.	Formaldehyde	182-194	BCL2 apoptosis regulator	Homo sapiens	49-54
11277419-8	2001	In addition, it was found that in particular nuclear and mitotic Bcl-2, and to a lesser extent cytoplasmic Bcl-2 immunoreactivity, decreased after prolonged formaldehyde fixation, whereas Bax immunoreactivity diminished only slightly.	Formaldehyde	157-169	BCL2 apoptosis regulator	Homo sapiens	65-70
11277419-8	2001	In addition, it was found that in particular nuclear and mitotic Bcl-2, and to a lesser extent cytoplasmic Bcl-2 immunoreactivity, decreased after prolonged formaldehyde fixation, whereas Bax immunoreactivity diminished only slightly.	Formaldehyde	157-169	BCL2 apoptosis regulator	Homo sapiens	107-112
11289281-4	2001	METHODS: Mutation screening of the hot spots of the K-ras gene and of the evolutionarily conserved regions of the TP53 gene was performed by denaturing gradient gel electrophoresis technique in formalin-fixed paraffin-embedded specimens of 55 consecutive patients with Dukes C colon cancer treated with adjuvant 5-fluorouracil-based chemotherapy.	Formaldehyde	194-202	KRAS proto-oncogene, GTPase	Homo sapiens	52-57
11289281-4	2001	METHODS: Mutation screening of the hot spots of the K-ras gene and of the evolutionarily conserved regions of the TP53 gene was performed by denaturing gradient gel electrophoresis technique in formalin-fixed paraffin-embedded specimens of 55 consecutive patients with Dukes C colon cancer treated with adjuvant 5-fluorouracil-based chemotherapy.	Formaldehyde	194-202	tumor protein p53	Homo sapiens	114-118
11209122-2	2001	OBJECTIVE: Our purpose was to determine the staining pattern and usefulness of MIB-1 antibody, which recognizes Ki-67 antigen in formalin-fixed, paraffin-embedded tissue, as an adjunct to the histopathologic differential diagnosis of SN.	Formaldehyde	129-137	MIB E3 ubiquitin protein ligase 1	Homo sapiens	79-84
11277417-4	2001	The authors compared the use of different types of probes to detect calcitonin mRNA in 10 cases of formalin-fixed, paraffin-embedded medullary thyroid carcinoma with and without TSA.	Formaldehyde	99-107	calcitonin related polypeptide alpha	Homo sapiens	68-78
11277417-7	2001	These results show that cRNA probes are the most sensitive types of probes for detecting mRNA molecules in formalin-fixed, paraffin-embedded tissue sections and that tyramide amplification can increase the sensitivity for detection of calcitonin mRNA in formalin-fixed, paraffin-embedded tissue sections at least 2- to 4-fold with cRNA probes.	Formaldehyde	254-262	calcitonin related polypeptide alpha	Homo sapiens	235-245
11277419-0	2001	Routine formaldehyde fixation irreversibly reduces immunoreactivity of Bcl-2 in the nuclear compartment of breast cancer cells, but not in the cytoplasm.	Formaldehyde	8-20	BCL2 apoptosis regulator	Homo sapiens	71-76
11277419-4	2001	In their experience, nuclear or mitotic staining of Bcl-2, in contrast with cytoplasmic Bcl-2 immunoreactivity, is rarely observed in formaldehyde-fixed, paraffin-embedded breast cancer specimens.	Formaldehyde	134-146	BCL2 apoptosis regulator	Homo sapiens	52-57
11248369-2	2001	To confirm the existence of such modulation in c-Fos expression in the trigeminal system, changes in c-Fos expression in the trigeminal nucleus caudalis induced by formalin injection into the rat whisker pad were examined by previously injecting formalin into different areas (contralateral whisker pad, ipsilateral or contralateral forepaw) of the body.	Formaldehyde	164-172	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	101-106
11248369-3	2001	Formalin injection-evoked c-Fos expression in this nucleus was significantly reduced by previous formalin injection into the contralateral whisker pad or ipsilateral forepaw but not into the contralateral forepaw.	Formaldehyde	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	26-31
11248369-3	2001	Formalin injection-evoked c-Fos expression in this nucleus was significantly reduced by previous formalin injection into the contralateral whisker pad or ipsilateral forepaw but not into the contralateral forepaw.	Formaldehyde	97-105	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	26-31
11248369-4	2001	The interval between the two injections of formalin that produced a maximal reduction of formalin injection-evoked c-Fos expression was 1 h, and the reduction of c-Fos expression was less when the interval of the two noxious stimuli was longer or shorter than 1 h. These results suggested that noxious stimulus-evoked c-Fos expression in the trigeminal nucleus caudalis is reduced by noxious stimulus applied previously to remote areas, and the reduction is dependent on the area of previous noxious stimulation and interval between the two noxious stimuli.	Formaldehyde	43-51	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	115-120
11248369-4	2001	The interval between the two injections of formalin that produced a maximal reduction of formalin injection-evoked c-Fos expression was 1 h, and the reduction of c-Fos expression was less when the interval of the two noxious stimuli was longer or shorter than 1 h. These results suggested that noxious stimulus-evoked c-Fos expression in the trigeminal nucleus caudalis is reduced by noxious stimulus applied previously to remote areas, and the reduction is dependent on the area of previous noxious stimulation and interval between the two noxious stimuli.	Formaldehyde	89-97	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	115-120
11228966-5	2001	Moreover, formaldehyde concentrations higher than 50 mg L-1 provoked a loss of efficiency of urea hydrolysis, decreasing to 10% at formaldehyde concentrations above 300 mg L-1.	Formaldehyde	10-22	immunoglobulin kappa variable 1-16	Homo sapiens	56-59
11228966-5	2001	Moreover, formaldehyde concentrations higher than 50 mg L-1 provoked a loss of efficiency of urea hydrolysis, decreasing to 10% at formaldehyde concentrations above 300 mg L-1.	Formaldehyde	10-22	immunoglobulin kappa variable 1-16	Homo sapiens	172-175
11228966-5	2001	Moreover, formaldehyde concentrations higher than 50 mg L-1 provoked a loss of efficiency of urea hydrolysis, decreasing to 10% at formaldehyde concentrations above 300 mg L-1.	Formaldehyde	131-143	immunoglobulin kappa variable 1-16	Homo sapiens	172-175
11228966-7	2001	However, denitrification proceeded properly even at a formaldehyde concentration of 700 mg L-1 in the reactor, although nitrous oxide appears in the off-gas.	Formaldehyde	54-66	immunoglobulin kappa variable 1-16	Homo sapiens	91-94
11207661-5	2001	We used polyclonal monospecific antibodies to detect cells expressing IL-2, IL-4, IL-6, IL-10 and IL-15, tumour necrosis factor (TNF-alpha) and interferon-gamma (IFN-gamma) in formalin-fixed, paraffin-embedded sections of granulation tissue from periodontitis lesions.	Formaldehyde	176-184	interferon gamma	Homo sapiens	144-160
11232861-2	2001	After hydrolysis of the conjugates with beta-glucuronidase/arylsulfatase a derivatisation step with formaldehyde converts fenoterol, orciprenaline, reproterol and terbutaline to one derivative, a tetrahydroisoquinoline, while the other beta-2 agonists remain unchanged.	Formaldehyde	100-112	glucuronidase beta	Homo sapiens	40-58
11232861-2	2001	After hydrolysis of the conjugates with beta-glucuronidase/arylsulfatase a derivatisation step with formaldehyde converts fenoterol, orciprenaline, reproterol and terbutaline to one derivative, a tetrahydroisoquinoline, while the other beta-2 agonists remain unchanged.	Formaldehyde	100-112	arylsulfatase A	Homo sapiens	59-74
11232861-2	2001	After hydrolysis of the conjugates with beta-glucuronidase/arylsulfatase a derivatisation step with formaldehyde converts fenoterol, orciprenaline, reproterol and terbutaline to one derivative, a tetrahydroisoquinoline, while the other beta-2 agonists remain unchanged.	Formaldehyde	100-112	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	236-242
11232861-6	2001	The other beta-2 agonists are detected as parent compounds with the same recovery after sample preparation with and without formaldehyde.	Formaldehyde	124-136	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	10-16
11159207-0	2001	API2-MALT1 fusion transcripts involved in mucosa-associated lymphoid tissue lymphoma: multiplex RT-PCR detection using formalin-fixed paraffin-embedded specimens.	Formaldehyde	119-127	baculoviral IAP repeat containing 3	Homo sapiens	0-4
11159207-0	2001	API2-MALT1 fusion transcripts involved in mucosa-associated lymphoid tissue lymphoma: multiplex RT-PCR detection using formalin-fixed paraffin-embedded specimens.	Formaldehyde	119-127	MALT1 paracaspase	Homo sapiens	5-10
11234880-4	2001	In this study, we have investigated whether this 250-bp env sequence was also present in the formalin-fixed normal tissues of individuals with env sequence-positive breast cancer.	Formaldehyde	93-101	endogenous retrovirus group K member 20	Homo sapiens	56-59
11234880-4	2001	In this study, we have investigated whether this 250-bp env sequence was also present in the formalin-fixed normal tissues of individuals with env sequence-positive breast cancer.	Formaldehyde	93-101	endogenous retrovirus group K member 20	Homo sapiens	143-146
11159766-3	2001	METHODS: A quantitative real-time reverse transcription (RT)-PCR assay was developed for cyclin D1 mRNA suitable for use with RNA extracted from fresh and formalin-fixed, paraffin-embedded tissues.	Formaldehyde	155-163	cyclin D1	Homo sapiens	89-98
11146056-0	2001	Antagonist of nicotinic acetylcholine receptors (nAChR) enhances formalin-induced nociception in rats: tonic role of nAChRs in the control of pain following injury.	Formaldehyde	65-73	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	49-54
11156682-3	2001	We describe a reverse transcriptase in situ PCR (RT in situ PCR) method that permits the target-specific direct incorporation of the reporter nucleotide into the different transcripts that comprise the TCR beta, using paraffin-embedded, formalin-fixed tissue.	Formaldehyde	237-245	T cell receptor beta locus	Homo sapiens	202-210
11276584-2	2001	In this study, we showed that intranasal immunization of pigs with formalin-inactivated or ether-split influenza vaccine (A/Aichi/2/68) induced virus-specific IgG, IgM, and IgA antibodies in their nasal secretions and sera, resulting in complete protection from virus challenge.	Formaldehyde	67-75	IGHA	Sus scrofa	173-176
11165019-4	2001	Immunohistochemical studies on 10% formalin fixed and paraffin embedded sections of human tissues showed that Pan1b was present in acini and ciliated epithelia of the lung.	Formaldehyde	35-43	hydroxysteroid 17-beta dehydrogenase 11	Homo sapiens	110-115
11114476-1	2001	Formalin-induced nociceptive behaviors and N-methyl-D-aspartate (NMDA) subtype glutamate receptor-mediated excitatory synaptic transmission were analyzed in mutant mice lacking D-amino-acid oxidase, which catalyzes the oxidative deamination of D-amino acids.	Formaldehyde	0-8	D-amino acid oxidase	Mus musculus	177-197
14700481-6	2001	Formalin-fixed, paraffin-embedded tumor tissue samples were stained with p185/HER2 receptor antibody.	Formaldehyde	0-8	eukaryotic translation initiation factor 3 subunit A	Homo sapiens	73-77
11156585-0	2001	Modulation of BzATP and formalin induced nociception: attenuation by the P2X receptor antagonist, TNP-ATP and enhancement by the P2X(3) allosteric modulator, cibacron blue.	Formaldehyde	24-32	purinergic receptor P2X 3	Rattus norvegicus	129-135
11156585-13	2001	The ability of TNP-ATP and cibacron blue to respectively attenuate and enhance nociceptive responses elicited by exogenous BzATP and formalin provide further support for the hypothesis that activation of peripheral P2X(3) containing channels contributes specifically to both acute and persistent nociception in the rat.	Formaldehyde	133-141	purinergic receptor P2X 3	Rattus norvegicus	215-221
11530860-1	2001	PURPOSE: To study the immunolocalization of the Bcl-2 protein in formalin-fixed placental tissue collected from uncomplicated term pregnancies.	Formaldehyde	65-73	BCL2 apoptosis regulator	Homo sapiens	48-53
11305953-4	2001	MATERIALS AND METHODS: We studied the expression of the genes encoding multidrug resistance associated protein (MDR1) and lung cancer associated resistance protein (LRP) in formalin-fixed, paraffin-embedded tumor samples from 52 patients treated for locally advanced breast cancer by means of induction chemotherapy followed by rescue mastectomy.	Formaldehyde	173-181	ATP binding cassette subfamily C member 3	Homo sapiens	71-110
11305953-4	2001	MATERIALS AND METHODS: We studied the expression of the genes encoding multidrug resistance associated protein (MDR1) and lung cancer associated resistance protein (LRP) in formalin-fixed, paraffin-embedded tumor samples from 52 patients treated for locally advanced breast cancer by means of induction chemotherapy followed by rescue mastectomy.	Formaldehyde	173-181	ATP binding cassette subfamily B member 1	Homo sapiens	112-116
11305953-4	2001	MATERIALS AND METHODS: We studied the expression of the genes encoding multidrug resistance associated protein (MDR1) and lung cancer associated resistance protein (LRP) in formalin-fixed, paraffin-embedded tumor samples from 52 patients treated for locally advanced breast cancer by means of induction chemotherapy followed by rescue mastectomy.	Formaldehyde	173-181	LDL receptor related protein 1	Homo sapiens	165-168
11119603-10	2001	Also, IRF-7 can bind to the Tap-2 promoter under physiological conditions in vivo, as shown by formaldehyde cross-linking, as well as to the Tap-2 ISRE in vitro, as shown by gel mobility shift assays.	Formaldehyde	95-107	interferon regulatory factor 7	Homo sapiens	6-11
11134244-11	2001	Weak immunoreactivity for polycystin-2, which was markedly enhanced by protease digestion, was detected in formaldehyde-fixed normal human elastic and intracranial arteries.	Formaldehyde	107-119	polycystin 2, transient receptor potential cation channel	Homo sapiens	26-38
11223819-1	2001	BACKGROUND: Immunohistological methods for the detection of estrogen receptor in human breast cancer using formalin-fixed, paraffin-embedded tissue not only have the advantages of being cheaper and requiring less tissue but also have several theoretical advantages.	Formaldehyde	107-115	estrogen receptor 1	Homo sapiens	60-77
12426170-2	2001	METHODS: Immunohistochemical method was used to detect the expression of CD20, CD45RO and cyclin D1 in 31 formalin- fixed and paraffin-embedded tissue samples of human small cell lymphomas.	Formaldehyde	106-114	keratin 20	Homo sapiens	73-77
12426170-2	2001	METHODS: Immunohistochemical method was used to detect the expression of CD20, CD45RO and cyclin D1 in 31 formalin- fixed and paraffin-embedded tissue samples of human small cell lymphomas.	Formaldehyde	106-114	cyclin D1	Homo sapiens	90-99
11166147-4	2001	Immunohistochemical detection of Glut1 protein was examined in 141 formalin-fixed and paraffin-embedded colorectal tumour specimens (57 adenomas, 84 carcinomas).	Formaldehyde	67-75	solute carrier family 2 member 1	Homo sapiens	33-38
11112688-8	2001	Immunofluorescence, cell fractionation, and formaldehyde cross-linking show that Df31 is associated with chromatin and that a significant fraction of it binds very tightly.	Formaldehyde	44-56	Decondensation factor 31	Drosophila melanogaster	81-85
11301206-2	2001	anaesthetized rats, we investigated the influence exercised by medial septal cholinergic neurons on dorsal hippocampus field CA1 neural responses to a hind paw injection of formalin (5%, 0.05 ml, s.c.).	Formaldehyde	173-181	carbonic anhydrase 1	Rattus norvegicus	125-128
21340899-3	2001	The ICRF In Situ Hybridization Service has hybridized more than 44,000 sections of principally formalin-fixed, paraffin wax-embedded tissues, with a high success rate.	Formaldehyde	95-103	regenerating family member 1 alpha	Homo sapiens	4-8
11301206-7	2001	Further, in comparison to vehicle-treated animals, selective cholinergic destruction attenuated formalin-induced; (i) theta activation, (ii) suppression of CA1 pyramidal cell population spike and dendritic field excitatory post-synaptic potential, (iii) inhibition of complex spike cell extracellular activity, and (iv) excitation and theta-rhythmicity of local putative GABAergic interneurons.	Formaldehyde	96-104	carbonic anhydrase 1	Rattus norvegicus	156-159
11669559-6	2001	Formalin-fixed, paraffin-embedded tissues were treated with anti-bcl-2 antibody (Dako No M0887).	Formaldehyde	0-8	BCL2 apoptosis regulator	Homo sapiens	65-70
11530233-0	2001	Heme oxygenase inhibitors reduce formalin-induced Fos expression in mouse spinal cord tissue.	Formaldehyde	33-41	FBJ osteosarcoma oncogene	Mus musculus	50-53
11530233-2	2001	Since it has been observed that heme oxygenase inhibitors reduce formalin-induced pain behaviors in mice and rats, we attempted to determine if this analgesic effect was reflected in a reduction in formalin-induced spinal cord Fos expression, an index of neuronal activation.	Formaldehyde	198-206	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	227-230
11530233-5	2001	It was also observed that mice lacking expression of heme oxygenase type 2, an isozyme of heme oxygenase found in high abundance in the spinal cord, had lowered Fos expression after the formalin injection.	Formaldehyde	186-194	FBJ osteosarcoma oncogene	Mus musculus	161-164
11530233-7	2001	Double-labeling experiments showed that a high percentage of Fos-positive nuclei identified after administration of formalin were located within heme oxygenase type 2-positive cell profiles.	Formaldehyde	116-124	FBJ osteosarcoma oncogene	Mus musculus	61-64
11166133-0	2001	Inhibition of spinal N-acetylated-alpha-linked acidic dipeptidase produces an antinociceptive effect in the rat formalin test.	Formaldehyde	112-120	folate hydrolase 1	Rattus norvegicus	21-65
11793965-0	2001	Participation of COX, IL-1 beta and TNF alpha in formalin-induced inflammatory pain.	Formaldehyde	49-57	cytochrome c oxidase subunit 8A	Homo sapiens	17-20
11793965-0	2001	Participation of COX, IL-1 beta and TNF alpha in formalin-induced inflammatory pain.	Formaldehyde	49-57	interleukin 1 beta	Homo sapiens	22-31
11793965-0	2001	Participation of COX, IL-1 beta and TNF alpha in formalin-induced inflammatory pain.	Formaldehyde	49-57	tumor necrosis factor	Homo sapiens	36-45
11113296-1	2000	The involvement of 5-HT(3) receptor mediated modulation of formalin and carrageenan induced inflammatory transmission was investigated.	Formaldehyde	59-67	5-hydroxytryptamine receptor 3A	Rattus norvegicus	19-35
11153665-3	2000	In vitro high resolution magnetic resonance spectroscopy of snap frozen intact tissue and quantitative neuropathology measurements of synaptophysin, calbindin, and glial fibrillary acidic protein (GFAP) in formalin-fixed tissue were performed.	Formaldehyde	206-214	glial fibrillary acidic protein	Homo sapiens	197-201
11135226-3	2000	METHODS: The authors studied COX-1 and -2 expression in 20 tumors of the lung, colon, and breast (60 total) by using commercially available monoclonal and polyclonal antibodies on formalin fixed, paraffin embedded tissue.	Formaldehyde	180-188	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	29-41
11193470-6	2000	Immunohistochemical expression of beta-catenin was studied in formalin-fixed, paraffin-embedded tissue samples.	Formaldehyde	62-70	catenin beta 1	Homo sapiens	34-46
11137256-3	2000	We found that both native and mildly formaldehyde-treated CRM(197) and conventional diphtheria toxoid (DT) induced mixed Th1/Th2 responses and similar levels of anti-DT serum IgG following parenteral immunization.	Formaldehyde	37-49	negative elongation factor complex member C/D, Th1l	Mus musculus	121-124
11137256-3	2000	We found that both native and mildly formaldehyde-treated CRM(197) and conventional diphtheria toxoid (DT) induced mixed Th1/Th2 responses and similar levels of anti-DT serum IgG following parenteral immunization.	Formaldehyde	37-49	heart and neural crest derivatives expressed 2	Mus musculus	125-128
11125889-4	2000	A highly specific anti-gp120 polyclonal sera was used on formalin fixed tissue.	Formaldehyde	57-65	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	23-28
11131586-3	2000	PROCEDURE: Expression of mRNA of inflammatory cytokines such as tumor necrosis factor alpha (TNFalpha), interleukin (IL)-1beta IL-6, and IL-8 in formalin-fixed paraffin-embedded blocks of lymphoid tissue (lymph nodes and tonsil) of swine experimentally infected with M. avium serovar 2 was compared with that of noninfected pigs.	Formaldehyde	145-153	tumor necrosis factor	Sus scrofa	64-91
11131586-3	2000	PROCEDURE: Expression of mRNA of inflammatory cytokines such as tumor necrosis factor alpha (TNFalpha), interleukin (IL)-1beta IL-6, and IL-8 in formalin-fixed paraffin-embedded blocks of lymphoid tissue (lymph nodes and tonsil) of swine experimentally infected with M. avium serovar 2 was compared with that of noninfected pigs.	Formaldehyde	145-153	tumor necrosis factor	Sus scrofa	93-101
11131586-3	2000	PROCEDURE: Expression of mRNA of inflammatory cytokines such as tumor necrosis factor alpha (TNFalpha), interleukin (IL)-1beta IL-6, and IL-8 in formalin-fixed paraffin-embedded blocks of lymphoid tissue (lymph nodes and tonsil) of swine experimentally infected with M. avium serovar 2 was compared with that of noninfected pigs.	Formaldehyde	145-153	C-X-C motif chemokine ligand 8	Sus scrofa	137-141
10838025-3	2000	In this study, some practical problems of two common unmasking techniques, i.e. heat-induced epitope retrieval and enzyme digestion have been reviewed in immunostaining of proliferating cell nuclear antigen (PCNA) on formaldehyde-fixed paraffin-embedded sections.	Formaldehyde	217-229	proliferating cell nuclear antigen	Homo sapiens	172-206
10838025-3	2000	In this study, some practical problems of two common unmasking techniques, i.e. heat-induced epitope retrieval and enzyme digestion have been reviewed in immunostaining of proliferating cell nuclear antigen (PCNA) on formaldehyde-fixed paraffin-embedded sections.	Formaldehyde	217-229	proliferating cell nuclear antigen	Homo sapiens	208-212
11127916-4	2000	Thirty-nine of the 40 (97%) flow cytometric CD10-positive cases also expressed CD10 by immunohistochemistry in formalin- or B5-fixed, paraffin-embedded tissue, with only one case of precursor B-lymphoblastic leukemia being positive by flow cytometry and negative by immunohistochemistry.	Formaldehyde	111-119	membrane metalloendopeptidase	Homo sapiens	44-48
11127916-4	2000	Thirty-nine of the 40 (97%) flow cytometric CD10-positive cases also expressed CD10 by immunohistochemistry in formalin- or B5-fixed, paraffin-embedded tissue, with only one case of precursor B-lymphoblastic leukemia being positive by flow cytometry and negative by immunohistochemistry.	Formaldehyde	111-119	membrane metalloendopeptidase	Homo sapiens	79-83
11127916-8	2000	This study demonstrates that the new CD10 monoclonal antibody clone 56C6 is a reliable marker for detection of CD10 antigen expression in formalin-and B5-fixed paraffin-embedded tissue after heat-induced epitope retrieval when compared with flow cytometry detection of fresh tissue samples.	Formaldehyde	138-146	membrane metalloendopeptidase	Homo sapiens	37-41
11127916-8	2000	This study demonstrates that the new CD10 monoclonal antibody clone 56C6 is a reliable marker for detection of CD10 antigen expression in formalin-and B5-fixed paraffin-embedded tissue after heat-induced epitope retrieval when compared with flow cytometry detection of fresh tissue samples.	Formaldehyde	138-146	membrane metalloendopeptidase	Homo sapiens	111-115
11195465-6	2000	A panel of 45 formalin-fixed and paraffin-embedded NSCLC specimens showed positive immunostaining for TGF-beta 1, TGF-beta RI, and TGF-beta RII, with reduced TGF-beta RII in poorly differentiated adenocarcinomas and squamous cell carcinomas and some moderately differentiated adenocarcinomas.	Formaldehyde	14-22	transforming growth factor, beta 1	Mus musculus	102-112
11195465-6	2000	A panel of 45 formalin-fixed and paraffin-embedded NSCLC specimens showed positive immunostaining for TGF-beta 1, TGF-beta RI, and TGF-beta RII, with reduced TGF-beta RII in poorly differentiated adenocarcinomas and squamous cell carcinomas and some moderately differentiated adenocarcinomas.	Formaldehyde	14-22	transforming growth factor, beta 1	Mus musculus	102-110
11195465-6	2000	A panel of 45 formalin-fixed and paraffin-embedded NSCLC specimens showed positive immunostaining for TGF-beta 1, TGF-beta RI, and TGF-beta RII, with reduced TGF-beta RII in poorly differentiated adenocarcinomas and squamous cell carcinomas and some moderately differentiated adenocarcinomas.	Formaldehyde	14-22	transforming growth factor beta receptor 2	Homo sapiens	131-143
11195465-6	2000	A panel of 45 formalin-fixed and paraffin-embedded NSCLC specimens showed positive immunostaining for TGF-beta 1, TGF-beta RI, and TGF-beta RII, with reduced TGF-beta RII in poorly differentiated adenocarcinomas and squamous cell carcinomas and some moderately differentiated adenocarcinomas.	Formaldehyde	14-22	transforming growth factor beta receptor 2	Homo sapiens	158-170
11063926-6	2000	In control animals, formalin induced robust pain behaviors and a marked transient increase in beta-endorphin release 30-60 min following injection.	Formaldehyde	20-28	proopiomelanocortin	Homo sapiens	94-108
11063926-7	2000	In contrast, pain behaviors were attenuated and the formalin-induced increase in beta-endorphin was completely blocked in adrenal medullary implanted animals.	Formaldehyde	52-60	proopiomelanocortin	Homo sapiens	81-95
11115725-0	2000	Both immunisation with a formalin-inactivated respiratory syncytial virus (RSV) vaccine and a mock antigen vaccine induce severe lung pathology and a Th2 cytokine profile in RSV-challenged mice.	Formaldehyde	25-33	heart and neural crest derivatives expressed 2	Mus musculus	150-153
11832196-3	2000	A DIG-labeled method of in situ hybridisation (ISH) was used to measure semiquantitatively MTA 1 mRNA in formalin-fixed, paraffin-embedded sections.	Formaldehyde	105-113	metastasis associated 1	Homo sapiens	91-96
11071316-6	2000	The present paper examines the distribution of the NK1 and NK3 receptors in the prefrontal cortex of formalin-fixed postmortem human brain tissue by immunohistochemical techniques.	Formaldehyde	101-109	tachykinin receptor 1	Homo sapiens	51-54
11062078-6	2000	Furthermore, formaldehyde-treated serum albumin (f-Alb), a ligand known to undergo scavenger-receptor-mediated endocytosis by LECs, was effectively taken up by MSR-A knock-out LECs at a capacity that did not differ from that of wild-type LECs.	Formaldehyde	13-25	methionine sulfoxide reductase A	Mus musculus	160-165
11073833-1	2000	Because formaldehyde exposure has been shown to induce pathological changes in human oral mucosa, eg, micronuclei, the potential enzymatic defense by alcohol dehydrogenase 3 (ADH3)/glutathione-dependent formaldehyde dehydrogenase was characterized in oral tissue specimens and cell lines using RNA hybridization and immunological methods as well as enzyme activity measurements.	Formaldehyde	8-20	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	150-173
11073833-1	2000	Because formaldehyde exposure has been shown to induce pathological changes in human oral mucosa, eg, micronuclei, the potential enzymatic defense by alcohol dehydrogenase 3 (ADH3)/glutathione-dependent formaldehyde dehydrogenase was characterized in oral tissue specimens and cell lines using RNA hybridization and immunological methods as well as enzyme activity measurements.	Formaldehyde	8-20	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	175-179
11073833-1	2000	Because formaldehyde exposure has been shown to induce pathological changes in human oral mucosa, eg, micronuclei, the potential enzymatic defense by alcohol dehydrogenase 3 (ADH3)/glutathione-dependent formaldehyde dehydrogenase was characterized in oral tissue specimens and cell lines using RNA hybridization and immunological methods as well as enzyme activity measurements.	Formaldehyde	8-20	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	203-229
11073833-9	2000	Finally, substantial capacity for formaldehyde detoxification is shown from quantitative assessments of alcohol- and aldehyde-oxidizing activities including K:(m) determinations, indicating that ADH3 is the major enzyme involved in formaldehyde oxidation in oral mucosa.	Formaldehyde	34-46	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	195-199
11073833-9	2000	Finally, substantial capacity for formaldehyde detoxification is shown from quantitative assessments of alcohol- and aldehyde-oxidizing activities including K:(m) determinations, indicating that ADH3 is the major enzyme involved in formaldehyde oxidation in oral mucosa.	Formaldehyde	232-244	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	195-199
11326673-4	2000	MATERIALS AND METHODS: In primary breast carcinoma samples from 115 women undergoing surgery in our department in 1999, a polyclonal rabbit antibody to human c-erbB-2 oncoprotein was used for immunohistochemical assessment of the c-erbB-2 expression in formalin-fixed paraffin-embedded material.	Formaldehyde	253-261	erb-b2 receptor tyrosine kinase 2	Homo sapiens	158-166
11071316-6	2000	The present paper examines the distribution of the NK1 and NK3 receptors in the prefrontal cortex of formalin-fixed postmortem human brain tissue by immunohistochemical techniques.	Formaldehyde	101-109	NK3 homeobox 1	Homo sapiens	59-62
11103961-1	2000	Nm23 protein expression was analyzed by immunohistochemical staining using formalin-fixed, paraffin-embedded sections from 39 cases with osteosarcomas and compared with the histologic findings and early metastasis for the purpose of detecting nm23 expression in osteosarcoma and elucidating the clinical significance of its expression.	Formaldehyde	75-83	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	0-4
11218759-9	2000	By using nested RT-PCR, we were able to detect MYH7 mRNA in myocardial tissue that had been fixed in formalin solution for 4 years.	Formaldehyde	101-109	myosin heavy chain 7	Homo sapiens	47-51
10998268-3	2000	Free amino groups of amylin and salmon calcitonin were methylated by reaction of peptides with formaldehyde and sodium [(3)H]borohydride.	Formaldehyde	95-107	islet amyloid polypeptide	Rattus norvegicus	21-27
11108903-11	2000	Thus, formaldehyde and paraformaldehyde have mild but complex influences on platelet P-selectin expression and fibrinogen binding measurements.	Formaldehyde	6-18	selectin P	Homo sapiens	85-95
11108903-11	2000	Thus, formaldehyde and paraformaldehyde have mild but complex influences on platelet P-selectin expression and fibrinogen binding measurements.	Formaldehyde	6-18	fibrinogen beta chain	Homo sapiens	111-121
11108903-7	2000	Resting P-selectin expression was not significantly altered by 0.2 or 0.5% formaldehyde fixation, but was slightly decreased by 1.0% formaldehyde fixation or PFA fixation.	Formaldehyde	133-145	selectin P	Homo sapiens	8-18
11108903-8	2000	Formaldehyde fixation caused small increases of P-selectin expression in ADP-stimulated samples.	Formaldehyde	0-12	selectin P	Homo sapiens	48-58
11069181-5	2000	P2X3-null mice have reduced pain-related behaviour in response to injection of ATP and formalin.	Formaldehyde	87-95	purinergic receptor P2X, ligand-gated ion channel, 3	Mus musculus	0-4
11021814-5	2000	In this study we examined the expression of Dpc4 protein in formalin-fixed archival tissue from 83 colorectal lesions, including 19 adenomas and 64 sporadic adenocarcinomas (11 stage I, 13 stage II, 17 stage III, and 23 stage IV cancers).	Formaldehyde	60-68	SMAD family member 4	Homo sapiens	44-48
11021819-3	2000	We examined BCL10 protein expression in various normal tissues and B-cell lymphomas by immunohistochemistry of formalin-fixed and paraffin-embedded tissues using mouse BCL10 monoclonal antibodies.	Formaldehyde	111-119	BCL10 immune signaling adaptor	Homo sapiens	12-17
11425189-3	2000	In this study, we describe a novel method of chemical deglycosylation of mucin gene products on paraffin embedded formalin-fixed tissue sections.	Formaldehyde	114-122	LOC100508689	Homo sapiens	73-78
11035594-5	2000	Immunoperoxidase studies on formalin-fixed, paraffin-embedded tissue demonstrated the neoplastic endothelial cells to be positive for vascular markers CD31 and CD34.	Formaldehyde	28-36	platelet and endothelial cell adhesion molecule 1	Homo sapiens	151-155
11063389-9	2000	The expression of PCNA was evaluated in formalin-fixed, paraffin-embedded gingival samples using an immunoperoxidase technique and PC 10 monoclonal antibody to PCNA.	Formaldehyde	40-48	proliferating cell nuclear antigen	Homo sapiens	18-22
11202158-11	2000	Our results emphasize that CFTR immunolabelling following formalin fixation has to be interpreted with the utmost caution.	Formaldehyde	58-66	CF transmembrane conductance regulator	Homo sapiens	27-31
11425189-7	2000	We conclude that this novel chemical deglycosylation method that causes selective cleavage of distinct glycans will be useful in unmasking various mucin gene products and glycoproteins containing similar O-glycosidic linkages in the tissue sections of formalin-fixed paraffin embedded normal and pathological tissues.	Formaldehyde	252-260	LOC100508689	Homo sapiens	147-152
11107054-5	2000	In the three cases, a reverse transcription-polymerase chain reaction (RT-PCR) using ribonucleic acid extracted from formalin-fixed, paraffin-embedded tissues detected SYT-SSX1 fusion gene transcripts resulting from translocation t(X;18)(p11.2;q11.2), which is specific for synovial sarcoma.	Formaldehyde	117-125	synaptotagmin 1	Homo sapiens	168-171
11107054-5	2000	In the three cases, a reverse transcription-polymerase chain reaction (RT-PCR) using ribonucleic acid extracted from formalin-fixed, paraffin-embedded tissues detected SYT-SSX1 fusion gene transcripts resulting from translocation t(X;18)(p11.2;q11.2), which is specific for synovial sarcoma.	Formaldehyde	117-125	SSX family member 1	Homo sapiens	172-176
11097366-6	2000	We conclude that CD is a reliable ganglion cell differentiation marker, which can be used routinely to stain developing and mature ganglion cells in formalin-fixed, paraffin-embedded tissues.	Formaldehyde	149-157	cathepsin D	Homo sapiens	17-19
11103423-0	2000	[IgE allergy due to formaldehyde paste during endodontic treatment.	Formaldehyde	20-32	immunoglobulin heavy constant epsilon	Homo sapiens	1-4
11103423-3	2000	Allergic IgE mediated mechanisms were suggested by the clinical presentation, skin tests and high levels of anti-formaldehyde IgE.	Formaldehyde	113-125	immunoglobulin heavy constant epsilon	Homo sapiens	9-12
11103423-3	2000	Allergic IgE mediated mechanisms were suggested by the clinical presentation, skin tests and high levels of anti-formaldehyde IgE.	Formaldehyde	113-125	immunoglobulin heavy constant epsilon	Homo sapiens	126-129
11131659-3	2000	METHODS: We investigated the immunohistochemical expression of the CD10 antigen on formalin-fixed, paraffin-embedded tissue specimens of normal skin and 162 cutaneous proliferative lesions, mostly mesenchymal tumors.	Formaldehyde	83-91	membrane metalloendopeptidase	Homo sapiens	67-71
10993447-5	2000	METHODS: An immunohistochemical assay was performed to examine the expression of MMP-9 in 25 cases (formalin-fixed paraffin-embedded sections) of cholesteatoma, using an MMP-9-specific monoclonal antibody.	Formaldehyde	100-108	matrix metallopeptidase 9	Homo sapiens	81-86
11062698-5	2000	The aim of this study was to detect the protein expression patterns of MDR-1 product by immunohistochemistry in formalin-fixed-paraffin-embedded tissues.	Formaldehyde	112-120	ATP binding cassette subfamily B member 1	Homo sapiens	71-76
11043526-3	2000	Similar increase of NOS and c-fos was obtained in the brain stem after a somatic nociceptive stimulus, i.e. on the side of the formalin injection in the lip.	Formaldehyde	127-135	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	28-33
11268475-3	2000	PATIENTS AND METHODS: Nuclear immunohistochemical expression of p53 protein was determined in formalin-fixed paraffin-embedded archival tumor tissue samples from 190 primary colorectal adenocarcinomas.	Formaldehyde	94-102	tumor protein p53	Homo sapiens	64-67
10975921-2	2000	DESIGN: Tenascin expression was evaluated in 75 formalin-fixed, paraffin-embedded biopsy and surgical specimens of the uterine cervix.	Formaldehyde	48-56	tenascin C	Homo sapiens	8-16
10940708-9	2000	CONCLUSIONS: RARalpha expression can be immunohistochemically evaluated in formalin-fixed paraffin-embedded prostatic tissue.	Formaldehyde	75-83	retinoic acid receptor alpha	Homo sapiens	13-21
10944602-3	2000	Pre-treatment tumour VEGF expression was examined immunohistochemically in formalin-fixed, paraffin-embedded biopsies using a widely available commercial antibody.	Formaldehyde	75-83	vascular endothelial growth factor A	Homo sapiens	21-25
11014570-12	2000	We conclude that immunohistochemical staining of paraffin-embedded tissue, either B5- or formalin-fixed, is an effective method for the detection of CD10 in acute leukemia.	Formaldehyde	89-97	membrane metalloendopeptidase	Homo sapiens	149-153
11030333-5	2000	Formaldehyde cross-linking revealed that in EC but not in differentiated cells, association of TBP with chromatin is strongly enhanced when complexed with TFIIA in vivo.	Formaldehyde	0-12	TATA-box binding protein	Homo sapiens	95-98
10953132-2	2000	MATERIALS AND METHODS: Immunohistochemical staining for p53 was semiquantitatively scored in archival formalin fixed, paraffin embedded tumor tissue obtained at diagnosis in 221 patients with prostate cancer.	Formaldehyde	102-110	tumor protein p53	Homo sapiens	56-59
11007039-3	2000	Commercially available antibodies capable of detecting myogenin in routinely processed formalin-fixed paraffin-embedded (FFPE) tissue are now available.	Formaldehyde	87-95	myogenin	Homo sapiens	55-63
11030333-5	2000	Formaldehyde cross-linking revealed that in EC but not in differentiated cells, association of TBP with chromatin is strongly enhanced when complexed with TFIIA in vivo.	Formaldehyde	0-12	general transcription factor IIA subunit 1	Homo sapiens	155-160
11037346-6	2000	Using double-label immunohistochemical techniques on formalin-fixed and paraffin-embedded tissues and specific antibodies directed against pituitary hormones and GnRHR, we found GnRHR immunoreactivity not only in FSH/LH cells, but also in GH- and thyroid-stimulating hormone (TSH) cells.	Formaldehyde	53-61	gonadotropin releasing hormone receptor	Homo sapiens	178-183
10963887-5	2000	It was revealed that intramuscular injection of formalin, in the anaesthetised rat, evoked a significant increase in Fos expression within the caudal vlPAG, and that approximately 25% of the Fos-immunoreactive neurons projected to the RVLM.	Formaldehyde	48-56	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	117-120
10963887-5	2000	It was revealed that intramuscular injection of formalin, in the anaesthetised rat, evoked a significant increase in Fos expression within the caudal vlPAG, and that approximately 25% of the Fos-immunoreactive neurons projected to the RVLM.	Formaldehyde	48-56	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	191-194
10945497-0	2000	Monoclonal antibody MA454 reveals a heterogeneous expression pattern of MAGE-1 antigen in formalin-fixed paraffin embedded lung tumours.	Formaldehyde	90-98	MAGE family member A1	Homo sapiens	72-86
10920202-4	2000	We generated polyclonal antibodies that bind to the VASA protein in formalin-fixed, paraffin-embedded tissue and characterized VASA protein expression in human germ cells at various stages of development.	Formaldehyde	68-76	vasa	Drosophila melanogaster	52-56
10935650-9	2000	In both cases, reverse transcription-polymerase chain reaction using ribonucleic acid extracted from formalin-fixed, paraffin-embedded tissues detected SYT-SSX2 fusion gene transcripts, which are characteristic molecular findings of synovial sarcoma.	Formaldehyde	101-109	synaptotagmin 1	Homo sapiens	152-155
10935650-9	2000	In both cases, reverse transcription-polymerase chain reaction using ribonucleic acid extracted from formalin-fixed, paraffin-embedded tissues detected SYT-SSX2 fusion gene transcripts, which are characteristic molecular findings of synovial sarcoma.	Formaldehyde	101-109	SSX family member 2	Homo sapiens	156-160
20950544-26	2000	TSP-1 can be detected reliably in formalin-fixed , paraffin-embedded tissues by immunohistochemical method.	Formaldehyde	34-42	thrombospondin 1	Homo sapiens	0-5
10899449-0	2000	Immunohistochemical staining of dystrophin on formalin-fixed paraffin-embedded sections in Duchenne/Becker muscular dystrophy and manifesting carriers of Duchenne muscular dystrophy.	Formaldehyde	46-54	dystrophin	Homo sapiens	32-42
10899449-1	2000	We succeeded in immunostaining of monoclonal anti-dystrophin antibodies on formalin-fixed and paraffin-embedded muscle sections from patients with Duchenne muscular dystrophy, patients with Becker muscular dystrophy, and manifesting carriers of Duchenne muscular dystrophy using Catalyzed Signal Amplification(TM) system.	Formaldehyde	75-83	dystrophin	Homo sapiens	50-60
10878567-3	2000	METHODS: TNFalpha-treated HUVEC monolayers were fixed with 0.5% formaldehyde at the end of the experimental incubation.	Formaldehyde	64-76	tumor necrosis factor	Homo sapiens	9-17
11218674-4	2000	An experiment was carried out to search the expression of CXCR4 retrospectively in FIV (CrFK) infected cat brain tissues using immunohistochemically in the formalin fixed paraffin sections against 12G5, a mouse monoclonal antibody to CXCR4.	Formaldehyde	156-164	C-X-C motif chemokine receptor 4	Homo sapiens	58-63
10998544-11	2000	Nocistatin also attenuated the allodynia and hyperalgesia evoked by prostaglandin E(2) and the inflammatory hyperalgesia induced by formalin or carrageenan/kaolin, and reversed the Noc/OFQ-induced inhibition of morphine analgesia at picogram doses.	Formaldehyde	132-140	prepronociceptin	Homo sapiens	0-10
10998544-11	2000	Nocistatin also attenuated the allodynia and hyperalgesia evoked by prostaglandin E(2) and the inflammatory hyperalgesia induced by formalin or carrageenan/kaolin, and reversed the Noc/OFQ-induced inhibition of morphine analgesia at picogram doses.	Formaldehyde	132-140	nocturnin	Homo sapiens	0-3
10910961-10	2000	XP-F cells showed somewhat higher sensitivity to formaldehyde, possibly signaling participation of XPF protein in the removal of residual peptide-DNA adducts.	Formaldehyde	49-61	ERCC excision repair 4, endonuclease catalytic subunit	Homo sapiens	99-102
10889339-3	2000	Noxious stimulation (subcutaneous injection of formalin into perioral regions) induced Fos-IR in some of GABA- and Gly-ir neurons.	Formaldehyde	47-55	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	87-90
10850547-2	2000	A novel polymerase chain reaction (PCR) approach for the analysis of the entire p53 coding and splice site regions from microdissected, formalin-fixed, paraffin-embedded tumor tissues has been developed which allows multiple genetic analyses to be performed from one primary amplification reaction.	Formaldehyde	136-144	tumor protein p53	Homo sapiens	80-83
10819903-0	2000	Maturation of NK1 receptor involvement in the nociceptive response to formalin.	Formaldehyde	70-78	tachykinin receptor 1	Rattus norvegicus	14-26
10819903-1	2000	Administration of NK1 antagonists in adult animals attenuates the nociceptive response in the formalin test, indicating that the neurokinins and the NK1 receptor play a role in mediating this pain response.	Formaldehyde	94-102	tachykinin receptor 1	Rattus norvegicus	149-161
10897334-5	2000	RESULTS: MMP-9 expression was demonstrated in the malignant Hodgkin and Reed-Sternberg cells of all (n = 86) formalin fixed, paraffin wax embedded Hodgkin"s disease tumours examined.	Formaldehyde	109-117	matrix metallopeptidase 9	Homo sapiens	9-14
10906633-5	2000	MATERIALS AND METHODS: It was proposed to quantify, using immunolabeling standard (QIFIKIT(R), Dako), surface expression of the main adherence receptors (L-selectin and B(2) integrins), from different preparations of PMN: total blood collected with EDTA, isolated PMN by density gradient Polymorphprep(TM) 1,113 (Nycomed Pharma) and formaldehyde fixed PMN.	Formaldehyde	333-345	selectin L	Homo sapiens	154-164
10874665-6	2000	Mdm2 and p53 were demonstrated by immunohistology on formalin-fixed and paraffin-embedded tumor tissue.	Formaldehyde	53-61	MDM2 proto-oncogene	Homo sapiens	0-4
10874665-6	2000	Mdm2 and p53 were demonstrated by immunohistology on formalin-fixed and paraffin-embedded tumor tissue.	Formaldehyde	53-61	tumor protein p53	Homo sapiens	9-12
10897337-3	2000	This is a highly selective approach, whereby immunostained sections of formalin fixed, paraffin wax embedded tissue are exposed to ultraviolet irradiation to damage the DNA in p53 negative cells.	Formaldehyde	71-79	tumor protein p53	Homo sapiens	176-179
10824754-5	2000	Formalin-fixed, paraffin-embedded tissue was processed for ploidy, S phase fraction, and immunohistochemical detection of estrogen and progesterone receptors plus expression of p53 and erbB-2 protein.	Formaldehyde	0-8	tumor protein p53	Homo sapiens	177-180
11021975-0	2000	Supraspinal NMDA and non-NMDA receptors are differentially involved in the production of antinociception by morphine and beta-endorphin administered intracerebroventricularly in the formalin pain model.	Formaldehyde	182-190	pro-opiomelanocortin-alpha	Mus musculus	121-135
11021975-5	2000	The formalin responses in the both phases were attenuated dose-dependently by morphine (0.125-1 microg) or beta-endorphin (0.125-1 microg) administered i.c.v.	Formaldehyde	4-12	pro-opiomelanocortin-alpha	Mus musculus	107-121
11021975-11	2000	Our results indicate that, at the supraspinal level, both NMDA and non-NMDA receptors are involved in the production of antinociception induced by supraspinally administered beta-endorphin, but not morphine, in the formalin pain model.	Formaldehyde	215-223	pro-opiomelanocortin-alpha	Mus musculus	174-188
11956571-9	2000	It is suggested that NO is involved in the increase of formalin-induced Fos-LI in the spinal cord of morphine-tolerant rats and may play an important role in the development of morphine tolerance.	Formaldehyde	55-63	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	72-75
11956571-0	2000	[Increased expression of formalin-induced Fos and NADPH-d positive neurons in the spinal cord of morphine-tolerant rats].	Formaldehyde	25-33	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	42-45
11956571-1	2000	Fos immunocytochemistry, NADPH-d histochemistry and Fos/NADPH-d double-labeling method were used to study the changes in formalin-induced Fos, NADPH-d positive and Fos/NADPH-d double-labeled neurons in the spinal cord of morphine-tolerant rats.	Formaldehyde	121-129	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	52-55
11956571-1	2000	Fos immunocytochemistry, NADPH-d histochemistry and Fos/NADPH-d double-labeling method were used to study the changes in formalin-induced Fos, NADPH-d positive and Fos/NADPH-d double-labeled neurons in the spinal cord of morphine-tolerant rats.	Formaldehyde	121-129	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	52-55
11956571-1	2000	Fos immunocytochemistry, NADPH-d histochemistry and Fos/NADPH-d double-labeling method were used to study the changes in formalin-induced Fos, NADPH-d positive and Fos/NADPH-d double-labeled neurons in the spinal cord of morphine-tolerant rats.	Formaldehyde	121-129	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	52-55
11956571-2	2000	Formalin-induced Fos-like immunoreactivity (Fos-LI) was located in the superficial laminae and neck of ipsilateral spinal cord.	Formaldehyde	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	17-20
11956571-2	2000	Formalin-induced Fos-like immunoreactivity (Fos-LI) was located in the superficial laminae and neck of ipsilateral spinal cord.	Formaldehyde	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	44-47
11956571-7	2000	A few formalin-induced Fos/NADPH-d double-labeled neurons were detected in the superficial laminae of spinal dorsal horn of non-tolerant rats.	Formaldehyde	6-14	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	23-26
11956571-8	2000	In morphine-tolerant rats, on the other hand, formalin-induced Fos/NADPH-d double-labeled neurons were increased and distributed in the whole laminae of the ipsilateral spinal cord and the contralateral superficial spinal cord.	Formaldehyde	46-54	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	63-66
10824754-5	2000	Formalin-fixed, paraffin-embedded tissue was processed for ploidy, S phase fraction, and immunohistochemical detection of estrogen and progesterone receptors plus expression of p53 and erbB-2 protein.	Formaldehyde	0-8	erb-b2 receptor tyrosine kinase 2	Homo sapiens	185-191
10785471-3	2000	METHODS: The expression of p21 was evaluated by immunohistochemical analysis with the monoclonal antibody WAF1 (Oncogene Science) on 106 formalin-fixed, paraffin-embedded tissue samples of epithelial ovarian cancer.	Formaldehyde	137-145	cyclin dependent kinase inhibitor 1A	Homo sapiens	27-30
10928048-3	2000	To evaluate whether E-cadherin could serve as a biomarker of squamous cell differentiation, we analyzed its expression by immunohistochemistry in formalin-fixed, paraffin-embedded tissue sections of 7 head and neck cancer patients, 19 lung cancer patients, 73 esophageal cancer patients, 19 skin cancer patients, and 18 cervical cancer patients.	Formaldehyde	146-154	cadherin 1	Homo sapiens	20-30
10765923-11	2000	CONCLUSION: Circulating DC precursors differentiate and express RelB after entry into rheumatoid ST. Differentiated DC can thus be identified by immunohistochemistry in formalin-fixed ST.	Formaldehyde	169-177	RELB proto-oncogene, NF-kB subunit	Homo sapiens	64-68
10748449-4	2000	Immunohistochemical localization of PRL was performed on formalin-fixed paraffin-embedded tissue sections.	Formaldehyde	57-65	prolactin	Homo sapiens	36-39
10904880-4	2000	The results revealed that only in buffered formalin-fixed tumor specimens, considering the most darkly stained cells, the PCNA-LI in all cases overlapped with T-LI.	Formaldehyde	43-51	proliferating cell nuclear antigen	Homo sapiens	122-126
10904880-5	2000	Higher values than those observed with autoradiography were detected in PCNA values obtained after usual formalin fixation whereas no or faint PCNA staining was seen in material fixed in Bouin.	Formaldehyde	105-113	proliferating cell nuclear antigen	Homo sapiens	72-76
10824929-2	2000	The present study investigated Rb immunohistochemistry in a series of 111 formalin-fixed, paraffin-embedded benign and malignant thyroid lesions.	Formaldehyde	74-82	RB transcriptional corepressor 1	Homo sapiens	31-33
10773422-0	2000	Inhibitory effect of intrathecally administered nociceptin on the expression of Fos-like immunoreactivity in the rat formalin test.	Formaldehyde	117-125	prepronociceptin	Rattus norvegicus	48-58
10773422-0	2000	Inhibitory effect of intrathecally administered nociceptin on the expression of Fos-like immunoreactivity in the rat formalin test.	Formaldehyde	117-125	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	80-83
10773422-1	2000	Nociceptin, an opioid receptor-like 1 receptor agonist, has been reported to produce an analgesic effect in the rat formalin test.	Formaldehyde	116-124	prepronociceptin	Rattus norvegicus	0-10
10773422-2	2000	The authors examined the effect of 17 nmol of nociceptin on the expression of Fos-like immunoreactivity (Fos-LI) in the spinal dorsal horn induced by paw formalin injection and compared the effect of 17 nmol of nociceptin with that of equiantinociceptive dose (3 nmol) of morphine.	Formaldehyde	154-162	prepronociceptin	Rattus norvegicus	46-56
10773422-2	2000	The authors examined the effect of 17 nmol of nociceptin on the expression of Fos-like immunoreactivity (Fos-LI) in the spinal dorsal horn induced by paw formalin injection and compared the effect of 17 nmol of nociceptin with that of equiantinociceptive dose (3 nmol) of morphine.	Formaldehyde	154-162	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	78-81
10773422-2	2000	The authors examined the effect of 17 nmol of nociceptin on the expression of Fos-like immunoreactivity (Fos-LI) in the spinal dorsal horn induced by paw formalin injection and compared the effect of 17 nmol of nociceptin with that of equiantinociceptive dose (3 nmol) of morphine.	Formaldehyde	154-162	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	105-108
10751581-3	2000	We found that after formalin was injected into the perioral skin of the upper lip of mice, the number of activated p44/42 MAPK-like immunoreactive neurons was significantly increased in the laminae I and II of the caudal subnucleus of the trigeminal spinal nucleus (Sp5C).	Formaldehyde	20-28	mitogen-activated protein kinase 3	Mus musculus	115-118
10862210-19	2000	Immunostaining with anti-Ki-67 antibodies (MIB1) and p53 based on formalin-fixed paraffin-embedded material from 86 patients revealed that MIB-1 &gt; or = 10% was associated with poorer metastasis-free survival but p53 was not.	Formaldehyde	66-74	MIB E3 ubiquitin protein ligase 1	Homo sapiens	139-144
10742212-12	2000	We suggest that, in vivo, EstA could be involved in (phospho)lipid metabolism or cellular detoxification or both, as its sequence showed significant similarity to S-formylglutathione hydrolase (FGH) of Paracoccus denitrificans and human EstD (or FGH), which are part of a universal formaldehyde detoxification pathway.	Formaldehyde	282-294	esterase D	Homo sapiens	194-197
10859677-3	2000	The present study demonstrates that creatine is metabolized to methylamine, which is further converted to formaldehyde by semicarbazide-sensitive amine oxidase (SSAO).	Formaldehyde	106-118	amine oxidase copper containing 2	Homo sapiens	122-159
10859677-3	2000	The present study demonstrates that creatine is metabolized to methylamine, which is further converted to formaldehyde by semicarbazide-sensitive amine oxidase (SSAO).	Formaldehyde	106-118	amine oxidase copper containing 2	Homo sapiens	161-165
10779663-0	2000	Heme oxygenase type 2 plays a role in formalin-induced nociception.	Formaldehyde	38-46	heme oxygenase 2	Mus musculus	0-21
10766191-3	2000	Immunohistochemistry for the Dpc4 protein in formalin-fixed, paraffin-embedded tissue is a sensitive and specific marker for DPC4 gene status, providing a tool to examine DPC4 status in these putative precursor lesions.	Formaldehyde	45-53	SMAD family member 4	Homo sapiens	29-33
10727645-3	2000	Fos-LI induction by the tooth pulp stimulation and by formalin injection to the lingual mucosa were only partially reduced.	Formaldehyde	54-62	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	0-3
10759946-3	2000	METHODS AND RESULTS: HSP27 expression was studied using immunohistochemistry on formalin-fixed, paraffin-embedded tissue sections from 21 oesophageal squamous cell carcinomas occurring in smokers and/or alcohol abusers.	Formaldehyde	80-88	heat shock protein family B (small) member 1	Homo sapiens	21-26
10759187-3	2000	The in situ hybridization procedure on formalin-fixed paraffin-embedded material was improved to such a degree that we could, for the first time, visualize AVP mRNA expressing neurons in the human SCN and carry out quantitative measurements.	Formaldehyde	39-47	arginine vasopressin	Homo sapiens	156-159
10889911-5	2000	These results indicate that SYT-SSX fusion transcripts are found in both epithelial and spindle cell areas of biphasic synovial sarcoma, and RT-DOP-PCR-PCR analysis is a useful method for detection of extremely small amounts of mRNA in microdissected samples from archival formalin fixed, paraffin wax embedded tumour tissues.	Formaldehyde	273-281	synaptotagmin 1	Homo sapiens	28-31
10889911-5	2000	These results indicate that SYT-SSX fusion transcripts are found in both epithelial and spindle cell areas of biphasic synovial sarcoma, and RT-DOP-PCR-PCR analysis is a useful method for detection of extremely small amounts of mRNA in microdissected samples from archival formalin fixed, paraffin wax embedded tumour tissues.	Formaldehyde	273-281	SSX family member 2	Homo sapiens	32-35
10704568-3	2000	METHODS: Twenty-nine formalin-fixed retinoblastoma specimens were examined by the labeled-streptavidin-biotin method using anti-Cox-2 antibody.	Formaldehyde	21-29	RB transcriptional corepressor 1	Homo sapiens	36-50
10834538-4	2000	VEGF immunostaining was performed on formalin-fixed, paraffin-embedded archival tissue from 74 renal carcinomas (62 conventional renal cell and 12 papillary carcinomas).	Formaldehyde	37-45	vascular endothelial growth factor A	Homo sapiens	0-4
10729626-0	2000	Phosphorylated cAMP response element binding protein increases in neurokinin-1 receptor-immunoreactive neurons in rat spinal cord in response to formalin-induced nociception.	Formaldehyde	145-153	tachykinin receptor 1	Rattus norvegicus	66-87
10729626-5	2000	Formalin injection produced an increase in pCREB-immunofluorescence within NK1 receptor-immunoreactive neurons from segments L4 and L5.	Formaldehyde	0-8	tachykinin receptor 1	Rattus norvegicus	75-87
10686408-5	2000	In normal males and females, formalin increased c-Fos in the dorsal DG and in the male ventral subfields.	Formaldehyde	29-37	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	48-53
10749136-6	2000	In the present study, we developed a monoclonal antibody found to recognize SSX2, SSX3, and SSX4 proteins expressed in formaldehyde-fixed and paraffin-embedded tissues.	Formaldehyde	119-131	SSX family member 2	Homo sapiens	76-80
10749136-6	2000	In the present study, we developed a monoclonal antibody found to recognize SSX2, SSX3, and SSX4 proteins expressed in formaldehyde-fixed and paraffin-embedded tissues.	Formaldehyde	119-131	SSX family member 3	Homo sapiens	82-86
10749136-6	2000	In the present study, we developed a monoclonal antibody found to recognize SSX2, SSX3, and SSX4 proteins expressed in formaldehyde-fixed and paraffin-embedded tissues.	Formaldehyde	119-131	SSX family member 4	Homo sapiens	92-96
10735609-0	2000	Detection of alpha-1-antitrypsin PiZ individuals by SSCP and DNA sequencing in formalin-fixed and paraffin-embedded tissue: a comparison with immunohistochemical analysis.	Formaldehyde	79-87	serpin family A member 1	Homo sapiens	13-32
10937050-14	2000	We conclude that cyclin D1 immunostaining of formalin-fixed, paraffin-embedded tissue can be reliably achieved by heat induces antigen retrieval and a cocktail of two monoclonal antibodies.	Formaldehyde	45-53	cyclin D1	Homo sapiens	17-26
10694553-2	2000	PATIENTS AND METHODS: We determined expression levels of the neurotrophin receptor TrkC mRNA in formalin-fixed tumor samples from 87 well characterized PNET patients using in situ hybridization.	Formaldehyde	96-104	brain derived neurotrophic factor	Homo sapiens	61-73
10694553-2	2000	PATIENTS AND METHODS: We determined expression levels of the neurotrophin receptor TrkC mRNA in formalin-fixed tumor samples from 87 well characterized PNET patients using in situ hybridization.	Formaldehyde	96-104	neurotrophic receptor tyrosine kinase 3	Homo sapiens	83-87
10718209-7	2000	In the present study the authors optimized a polymerase chain reaction-based mutation screening method, fluorescence-single strand conformation polymorphism (F-SSCP), that allows p53 status to be assessed accurately and reproducibly in routinely handled, formalin-fixed and paraffin-embedded tumor specimens.	Formaldehyde	255-263	tumor protein p53	Homo sapiens	179-182
10681388-2	2000	Using monoclonal antibodies (MAbs) against epitopes in the R-domain and C-terminus, we observed the following: Formalin fixation masks the CFTR epitopes but the epitopes are exposed by treatment with urea and heat (antigen retrieval).	Formaldehyde	111-119	CF transmembrane conductance regulator	Homo sapiens	139-143
10746928-4	2000	In the present study, NAT1- and NAT2-specific riboprobes were used in hybridization histochemistry studies to localize NAT1 and NAT2 mRNA sequences in formalin-fixed, paraffin-embedded human tissue sections.	Formaldehyde	151-159	N-acetyltransferase 1	Homo sapiens	119-123
10767172-6	2000	DMGDH and SDH also utilize a noncovalently bound folate coenzyme that receives the "1-carbon" groups that are removed by DMGDH and SDH, forming "active formaldehyde."	Formaldehyde	152-164	dimethylglycine dehydrogenase	Homo sapiens	0-5
10767172-6	2000	DMGDH and SDH also utilize a noncovalently bound folate coenzyme that receives the "1-carbon" groups that are removed by DMGDH and SDH, forming "active formaldehyde."	Formaldehyde	152-164	sarcosine dehydrogenase	Homo sapiens	10-13
10767172-6	2000	DMGDH and SDH also utilize a noncovalently bound folate coenzyme that receives the "1-carbon" groups that are removed by DMGDH and SDH, forming "active formaldehyde."	Formaldehyde	152-164	dimethylglycine dehydrogenase	Homo sapiens	121-126
10767172-6	2000	DMGDH and SDH also utilize a noncovalently bound folate coenzyme that receives the "1-carbon" groups that are removed by DMGDH and SDH, forming "active formaldehyde."	Formaldehyde	152-164	sarcosine dehydrogenase	Homo sapiens	131-134
10746928-4	2000	In the present study, NAT1- and NAT2-specific riboprobes were used in hybridization histochemistry studies to localize NAT1 and NAT2 mRNA sequences in formalin-fixed, paraffin-embedded human tissue sections.	Formaldehyde	151-159	N-acetyltransferase 2	Homo sapiens	128-132
10648792-0	2000	Formaldehyde activation of mitoxantrone yields CpG and CpA specific DNA adducts.	Formaldehyde	0-12	carboxypeptidase A1	Homo sapiens	55-58
11776642-2	2000	METHODS: The expression of MAGE-3 antigen was examined in formalin fixed, paraffin embedded sections of NSCLC by LSAB immunohistochemical technique.	Formaldehyde	58-66	MAGE family member A3	Homo sapiens	27-41
10650136-0	2000	Nitric oxide synthase and glutamate receptor immunoreactivity in the rat spinal trigeminal neurons expressing Fos protein after formalin injection.	Formaldehyde	128-136	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	110-113
10650136-2	2000	In this study, c-fos expression indicated by Fos immunohistochemistry in the caudal spinal trigeminal nucleus induced by subcutaneous injection of formalin into the lateral face of the rat was used as a marker for nociceptive neurons.	Formaldehyde	147-155	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	15-20
10650136-2	2000	In this study, c-fos expression indicated by Fos immunohistochemistry in the caudal spinal trigeminal nucleus induced by subcutaneous injection of formalin into the lateral face of the rat was used as a marker for nociceptive neurons.	Formaldehyde	147-155	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	45-48
10650136-4	2000	After formalin injection, many Fos-positive nuclei appeared in the superficial laminae of the ipsilateral trigeminal nucleus.	Formaldehyde	6-14	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	31-34
10656735-4	2000	MATERIALS AND METHODS: beta-Amyloid precursor protein immunohistochemistry was performed on formalin-fixed, paraffin-embedded sections of eyes (including optic disc and distal optic nerve) from infants less than 1 year of age with shaken baby syndrome (5 cases), combined shaken baby syndrome/blunt head trauma (3 cases), and "pure" blunt head trauma (1 case).	Formaldehyde	92-100	amyloid beta precursor protein	Homo sapiens	23-53
10649242-2	2000	METHODS: Using immunohistochemistry, the authors investigated FasL expression in sections of formalin fixed, paraffin embedded tissue from 13 EADCA.	Formaldehyde	93-101	Fas ligand	Homo sapiens	62-66
10718319-3	2000	In contrast, the NK1 receptor is involved in nociceptive responses to high intensity heat and mechanical stimuli, and mediates the second phase of the formalin response in 21-day-old mice.	Formaldehyde	151-159	tachykinin receptor 1	Mus musculus	17-29
10666384-5	2000	Forty of 52 (77%) formalin-fixed adenomas expressed immunoreactive COX-2.	Formaldehyde	18-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
10682666-3	2000	Immunohistochemical p53 (pAb 1801 mAb) and TS (TS106 mAb) expression on formalin-fixed paraffin-embedded primary tumour specimens was related to probability of clinical response to chemotherapy, time to progression and overall survival.	Formaldehyde	72-80	tumor protein p53	Homo sapiens	20-23
10683828-5	2000	We present evidence which indicates that the use of antisense oligonucleotides targeted to the NMDA-R1 receptor subunit (AS-NMDA-R1), but not sense, abolishes NMDA and formalin induced behaviors.	Formaldehyde	168-176	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	95-102
10685637-5	2000	We studied by immunohistochemistry formalin-fixed, paraffin-embedded sections with monoclonal antibodies to molecules known to be involved in lymphocyte and endothelial adhesion phenomena, that is, CD29 (beta1 integrin subunit), CD43 (leukosialin), CD44 (H-CAM), CD54 (ICAM-1), embryonal N-CAM (e-NCAM), and EMA (episialin).	Formaldehyde	35-43	integrin subunit beta 1	Homo sapiens	198-202
10657006-3	2000	Using commercial polyclonal antisera against peptides specific to human ERbeta, we have determined the sites of ERbeta expression in archival and formalin-fixed human tissue and compared its expression with that of ERalpha.	Formaldehyde	146-154	estrogen receptor 2	Homo sapiens	112-118
10640314-5	2000	Unlike its inhibition of formalin-evoked nociceptive behaviors, the effect of gabapentin on the expression of Fos-like immunoreactivity in the spinal cord was highly dependent on the concentration of formalin.	Formaldehyde	200-208	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	110-113
10741469-7	2000	Additionally, in situ hybridization experiments on formalin-fixed tissue demonstrated the presence of AE2 mRNA in the same segments of the distal nephron.	Formaldehyde	51-59	solute carrier family 4 member 2	Homo sapiens	102-105
10672059-5	2000	Monoclonal antibodies effective in formalin-fixed, paraffin-embedded tissue were successfully generated, designated NCL-CD5-4C7, NCL-CD10-270 and NCL-CD23-1B12, respectively.	Formaldehyde	35-43	nucleolin	Mus musculus	116-119
10672059-5	2000	Monoclonal antibodies effective in formalin-fixed, paraffin-embedded tissue were successfully generated, designated NCL-CD5-4C7, NCL-CD10-270 and NCL-CD23-1B12, respectively.	Formaldehyde	35-43	CD5 antigen	Mus musculus	120-123
10672059-5	2000	Monoclonal antibodies effective in formalin-fixed, paraffin-embedded tissue were successfully generated, designated NCL-CD5-4C7, NCL-CD10-270 and NCL-CD23-1B12, respectively.	Formaldehyde	35-43	nucleolin	Mus musculus	129-132
10672059-5	2000	Monoclonal antibodies effective in formalin-fixed, paraffin-embedded tissue were successfully generated, designated NCL-CD5-4C7, NCL-CD10-270 and NCL-CD23-1B12, respectively.	Formaldehyde	35-43	nucleolin	Mus musculus	129-132
10640975-16	2000	Compared with 7E11, the PM2J004.5 anti-PSMA mAb is a more sensitive immunohistochemical marker of prostate carcinoma in formalin fixed, paraffin embedded tissue.	Formaldehyde	120-128	folate hydrolase 1	Homo sapiens	39-43
10606672-5	2000	We also demonstrate, using an in vitro assay, that formaldehyde crosslinking accurately reflects the DNA binding specificities of both Zeste and a second transcription factor, Eve.	Formaldehyde	51-63	zeste	Drosophila melanogaster	135-140
10606672-3	2000	Here we show that formaldehyde crosslinking of Drosophila embryos maps an interaction of the transcription factor Zeste to a known target element in the Ultrabithorax promoter.	Formaldehyde	18-30	zeste	Drosophila melanogaster	114-119
10683828-5	2000	We present evidence which indicates that the use of antisense oligonucleotides targeted to the NMDA-R1 receptor subunit (AS-NMDA-R1), but not sense, abolishes NMDA and formalin induced behaviors.	Formaldehyde	168-176	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	124-131
10618603-4	2000	Immunohistochemical expression of nuclear p53 protein was assessed in formalin fixed, paraffin embedded archival tumor tissue.	Formaldehyde	70-78	tumor protein p53	Homo sapiens	42-45
10623653-3	2000	We developed a new and sensitive technique to detect PrP(Sc) in formalin-fixed and paraffin-embedded tissue, the paraffin-embedded tissue blot (PET blot), and reinvestigated archival brain material from CJD as well as BSE and scrapie.	Formaldehyde	64-72	prolactin family 7, subfamily d, member 1	Mus musculus	53-56
10658907-1	2000	We report the development of a reverse transcriptase polymerase chain reaction assay that reliably detects the ETV6-NTRK3 chimeric RNA characteristic of infantile fibrosarcoma and the cellular variant of congenital mesoblastic nephroma (CMN) in formalin-fixed, paraffin-embedded tissue blocks.	Formaldehyde	245-253	ETS variant transcription factor 6	Homo sapiens	111-115
10683288-4	2000	(Pain 75: 355-365) showed that autoradiographic estimates of regional cerebral blood flow (rCBF) can be used to simultaneously identify alterations in the activation of multiple forebrain structures responsive to noxious formalin stimulation.	Formaldehyde	221-229	CCAAT/enhancer binding protein zeta	Rattus norvegicus	91-95
16232936-0	2000	Formate dehydrogenase gene of Arabidopsis thaliana is induced by formaldehyde and not by formic acid.	Formaldehyde	65-77	formate dehydrogenase	Arabidopsis thaliana	0-21
16232936-3	2000	As a result, expression of the FDH gene in A. thaliana was not intensely influenced by formic acid, an inherent substrate for FDH, but strongly induced by its reduced form, formaldehyde.	Formaldehyde	173-185	formate dehydrogenase	Arabidopsis thaliana	31-34
10658907-1	2000	We report the development of a reverse transcriptase polymerase chain reaction assay that reliably detects the ETV6-NTRK3 chimeric RNA characteristic of infantile fibrosarcoma and the cellular variant of congenital mesoblastic nephroma (CMN) in formalin-fixed, paraffin-embedded tissue blocks.	Formaldehyde	245-253	neurotrophic receptor tyrosine kinase 3	Homo sapiens	116-121
11061213-1	2000	Under the influence of semicarbazide-sensitive amine oxidase (SSAO), methylamine is deaminated to formaldehyde, which can react with various macromolecules and form irreversible adducts.	Formaldehyde	98-110	amine oxidase, copper containing 3	Mus musculus	23-60
11061213-1	2000	Under the influence of semicarbazide-sensitive amine oxidase (SSAO), methylamine is deaminated to formaldehyde, which can react with various macromolecules and form irreversible adducts.	Formaldehyde	98-110	amine oxidase, copper containing 3	Mus musculus	62-66
10658633-5	2000	This was accompanied by a marked reduction in formalin-induced c-fos expression in the spinal dorsal horn.	Formaldehyde	46-54	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	63-68
10674271-1	2000	The aim of the current study was to investigate the immunohistochemical expression of the retinoblastoma protein (pRB) in formalin-fixed, paraffin-embedded specimens obtained from 62 patients suffering from endometrial cancer.	Formaldehyde	122-130	RB transcriptional corepressor 1	Homo sapiens	114-117
10670449-0	2000	Tachykinin receptor inhibition and c-Fos expression in the rat brain following formalin-induced pain.	Formaldehyde	79-87	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	35-40
10670449-2	2000	The expression of the inducible transcription factor, c-Fos, was used to identify areas in the brain activated by a noxious stimulus (the subcutaneous injection of formalin), and to investigate the effects of intracerebroventricular administration of selective, nonpeptide antagonists for neurokinin-1 and neurokinin-2 tachykinin receptors on the neural activity in these areas and on the behavioural response to formalin-induced pain.	Formaldehyde	164-172	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	54-59
10670449-2	2000	The expression of the inducible transcription factor, c-Fos, was used to identify areas in the brain activated by a noxious stimulus (the subcutaneous injection of formalin), and to investigate the effects of intracerebroventricular administration of selective, nonpeptide antagonists for neurokinin-1 and neurokinin-2 tachykinin receptors on the neural activity in these areas and on the behavioural response to formalin-induced pain.	Formaldehyde	413-421	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	54-59
10670449-3	2000	Formalin (5%, 50 microl), injected subcutaneously through a chronically implanted catheter in the region of the lower hindlimb, increased c-Fos expression in a number of brain areas related to nociceptive transmission or the integration of stress responses.	Formaldehyde	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	138-143
10670449-6	2000	The neurokinin-1, but not the neurokinin-2, receptor antagonist attenuated the formalin-induced activation of c-Fos in the paraventricular nucleus of the hypothalamus.	Formaldehyde	79-87	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	110-115
10640992-1	2000	A study was performed to investigate the utility of polymerase chain reaction (PCR)-based analysis of immunoglobulin heavy chain (IgH) gene rearrangements for the diagnosis of low-grade malignant B-cell lymphomas on formalin-fixed, EDTA-decalcified, and paraffin-embedded bone marrow trephine biopsies.	Formaldehyde	216-224	immunoglobulin heavy constant delta	Homo sapiens	102-128
10640992-1	2000	A study was performed to investigate the utility of polymerase chain reaction (PCR)-based analysis of immunoglobulin heavy chain (IgH) gene rearrangements for the diagnosis of low-grade malignant B-cell lymphomas on formalin-fixed, EDTA-decalcified, and paraffin-embedded bone marrow trephine biopsies.	Formaldehyde	216-224	immunoglobulin heavy constant delta	Homo sapiens	130-133
10889922-3	2000	Formalin-fixed sections were submitted to monoclonal antibody anti-Mdm2 through use of the streptavidin-biotin method.	Formaldehyde	0-8	MDM2 proto-oncogene	Homo sapiens	67-71
11033461-4	2000	To assess the tenascin-C expression formalin-fixed, paraffin-embedded specimens of 20 specially selected breast carcinomas and their recurrences (14) or a second primary breast cancer of the same patient (6) were examined with immunohistochemical methods.	Formaldehyde	36-44	tenascin C	Homo sapiens	14-24
10619261-3	1999	In this study, we investigated whether the antibody CD138/B-B4, which is an optimal marker for PC detection on BM aspirates by flow cytometry, can be used successfully for the identification of PCs also on formalin-fixed, decalcified biopsies.	Formaldehyde	206-214	syndecan 1	Homo sapiens	52-62
11098559-5	2000	In 1977, we proposed the use of gelatin-resorcin-formalin (GRF) biological glue to reinforce the suture areas.	Formaldehyde	49-57	growth hormone releasing hormone	Homo sapiens	59-62
10606817-6	1999	Sequence analysis of exons 5 through 8 of p53 was performed on cloned PCR-amplified DNA of formalin-fixed, paraffin-embedded tumors.	Formaldehyde	91-99	tumor protein p53	Homo sapiens	42-45
10602329-15	1999	These findings suggest that spinal endogenous ATP may play a role in (1) the formalin- and capsaicin-induced neurogenic pain via the PPADS- and TNP-ATP-sensitive P2X receptors which are also desensitized by alpha,betameATP (perhaps the P2X3 receptor subtype) and (2) formalin-induced inflammatory pain via PPADS-sensitive, TNP-ATP- and alpha,betameATP-insensitive P2X (and/or P2Y) receptors.	Formaldehyde	77-85	purinergic receptor P2X, ligand-gated ion channel, 3	Mus musculus	236-240
10605946-5	1999	Triple-immunofluorescence histochemistry further revealed that a number of CB-, CR-, or PV-immunoreactive TMR-DA-labeled MDH neurons showed immunoreactivity for substance P receptor (NK1), and that they expressed immunoreactivity for c-fos protein in the rats which were injected with formalin into the lips.	Formaldehyde	285-293	tachykinin receptor 1	Rattus norvegicus	161-181
10690175-2	1999	METHODS: 82 cases of apocrine metaplasia, including 18 of the rare lesion apocrine adenosis, were studied immunohistochemically for the expression of androgen receptor, oestrogen receptor, and progesterone receptor proteins on formalin fixed, paraffin embedded tissue sections.	Formaldehyde	227-235	progesterone receptor	Homo sapiens	150-214
10593203-0	1999	Effects of formalin pain on hippocampal c-Fos expression in male and female rats.	Formaldehyde	11-19	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	40-45
10593203-6	1999	In males at time 2, formalin increased c-Fos in the dentate gyrus (DG) and CA3 fields; at time 24, c-Fos returned to the control level; at time 24/OF, c-Fos was higher than in control in the DG, but not in the other fields.	Formaldehyde	20-28	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	39-44
10593203-6	1999	In males at time 2, formalin increased c-Fos in the dentate gyrus (DG) and CA3 fields; at time 24, c-Fos returned to the control level; at time 24/OF, c-Fos was higher than in control in the DG, but not in the other fields.	Formaldehyde	20-28	carbonic anhydrase 3	Rattus norvegicus	75-78
10593203-7	1999	In the formalin-treated females at time 2 and at time 24, c-Fos levels were lower, or tended to be lower, than in control in all hippocampal fields; at time 24/OF, c-Fos levels in the DG were higher than in control and in males.	Formaldehyde	7-15	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	58-63
10593203-7	1999	In the formalin-treated females at time 2 and at time 24, c-Fos levels were lower, or tended to be lower, than in control in all hippocampal fields; at time 24/OF, c-Fos levels in the DG were higher than in control and in males.	Formaldehyde	7-15	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	164-169
10697578-6	1999	The expression of primary tumor bcl-2 protein was immunohistochemically evaluated by antihuman bcl-2 monoclonal antibody (diluted 1:100, Dako, Copenhagen, Denmark) on formalin-fixed paraffin-embedded tissue.	Formaldehyde	167-175	BCL2 apoptosis regulator	Homo sapiens	32-37
10565681-0	1999	Detection of COL1A1-PDGFB fusion transcripts in dermatofibrosarcoma protuberans by reverse transcription-polymerase chain reaction using archival formalin-fixed, paraffin-embedded tissues.	Formaldehyde	146-154	collagen type I alpha 1 chain	Homo sapiens	13-19
10544218-3	1999	In this study we developed monoclonal antibodies (MAbs) to CYP1B1 that are effective on formalin-fixed, paraffin-embedded tissue sections and investigated the presence of CYP1B1 in a series of primary breast cancers.	Formaldehyde	88-96	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	59-65
10534582-7	1999	DELT given i.c.v., i.th., or into the MRF also blocked formalin-induced increase in Fos-like immunoreactivity (FLI) in the dorsal horn of lumbar spinal cord ipsilateral to the formalin injection.	Formaldehyde	55-63	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	84-87
10526210-3	1999	The metabolism of brominated THMs is thought to involve a GSH conjugation reaction leading either to formaldehyde or DNA-reactive intermediates via glutathione S-transferase-theta (GSTT1-1), which is polymorphic in humans.	Formaldehyde	101-113	glutathione S-transferase theta 1	Homo sapiens	181-188
10574264-2	1999	Immunohistochemical analysis of p53 was performed on formalin-fixed, paraffin-embedded specimens from 168 primary ovarian carcinomas by using the DO-7 monoclonal antibody.	Formaldehyde	53-61	tumor protein p53	Homo sapiens	32-35
10506927-4	1999	We used the monoclonal mouse anti-human phagocytic glycoprotein-1 CD44 (clone DF 1485), on formalin-fixed, paraffin-embedded tissue.	Formaldehyde	91-99	CD44 molecule (Indian blood group)	Homo sapiens	40-65
10493979-4	1999	Immunohistochemical staining for FAS was performed on formaline-fixed, paraffin-embedded sections.	Formaldehyde	54-63	fatty acid synthase	Homo sapiens	33-36
10398013-2	1999	A gelatin-resorcinol mixture crosslinked with formaldehyde (GRF glue) and/or glutaraldehyde (GRG) is used for this purpose.	Formaldehyde	46-58	growth hormone releasing hormone	Homo sapiens	60-63
10551739-1	1999	The expression of Fhit (fragile histidine triad) protein in oral squamous cell carcinoma (OSCC) and adjacent oral epithelium was evaluated by immunohistochemistry on formalin-fixed paraffin-embedded blocks of 32 cases of OSCC.	Formaldehyde	166-174	fragile histidine triad diadenosine triphosphatase	Homo sapiens	18-22
10593577-3	1999	Spleen cells of mice primarily infected from 2 to 8 weeks before produced a significant amount of TNF-alpha and IFN-gamma when stimulated with formalin-killed bacteria.	Formaldehyde	143-151	tumor necrosis factor	Mus musculus	98-107
10593577-3	1999	Spleen cells of mice primarily infected from 2 to 8 weeks before produced a significant amount of TNF-alpha and IFN-gamma when stimulated with formalin-killed bacteria.	Formaldehyde	143-151	interferon gamma	Mus musculus	112-121
10587092-4	1999	Solution hybridization-nuclease protection assays conducted 24 h after formalin injection into the right hindpaw of the rat revealed a significant bilateral increase in GABA(B) R1 and R2 receptor expression in the dorsal lumbar spinal cord, and a significant increase in GABA(B) R1 receptor mRNA in the ipsilateral lumbar dorsal root ganglion.	Formaldehyde	71-79	gamma-aminobutyric acid type B receptor subunit 1	Rattus norvegicus	169-179
10587092-4	1999	Solution hybridization-nuclease protection assays conducted 24 h after formalin injection into the right hindpaw of the rat revealed a significant bilateral increase in GABA(B) R1 and R2 receptor expression in the dorsal lumbar spinal cord, and a significant increase in GABA(B) R1 receptor mRNA in the ipsilateral lumbar dorsal root ganglion.	Formaldehyde	71-79	gamma-aminobutyric acid type B receptor subunit 1	Rattus norvegicus	271-281
10502729-4	1999	In a retrospective study of 62 formalin-fixed paraffin-embedded invasive EOBC (diagnosed at 35 years or less), the amplification status of the c-erbB-2 gene detected by fluorescence in situ hybridization (FISH) using a unique sequence probe was compared with p53 protein accumulation measured by immunohistochemistry (IHC) and phenotypic features.	Formaldehyde	31-39	erb-b2 receptor tyrosine kinase 2	Homo sapiens	143-151
10595700-0	1999	Microwave-stimulated recovery of myosin-V immunoreactivity from formalin-fixed, paraffin-embedded human CNS.	Formaldehyde	64-72	myosin VA	Homo sapiens	33-41
10560525-4	1999	Formalin-fixed, paraffin-embedded tissue sections were immunostained with a monoclonal antibody against p53 protein using an avidin-streptavidin method.	Formaldehyde	0-8	tumor protein p53	Homo sapiens	104-107
10892891-2	1999	Some previous studies on cultured endothelial cells indicate that cytotoxic metabolites (e.g. hydrogen peroxide, formaldehyde, acrolein) formed by serum SSAO may cause endothelial injury and subsequently induce atherosclerosis.	Formaldehyde	113-125	amine oxidase copper containing 2	Homo sapiens	153-157
10518106-5	1999	METHODS: p53 expression in formalin-fixed, paraffin-embedded samples of 239 patients with primary esophageal squamous cell carcinoma (TNM stage I:79 cases, stage II: 82 cases, stage III: 78 cases), who underwent esophageal resection without additional treatment, were analyzed by immunohistochemical staining using a polyclonal antibody, RSP53.	Formaldehyde	27-35	tumor protein p53	Homo sapiens	9-12
10530564-4	1999	MATERIAL AND METHODS: The immunohistochemical expression of Fhit was tested in normal kidneys and in 109 renal neoplasms consisting of 51 clear cell RCCs, 26 papillary RCCs, two chromophobe carcinomas, six oncocytomas, four pelvic transitional cell carcinomas and 20 Wilms" tumors from formalin fixed and routinely processed tissue.	Formaldehyde	286-294	fragile histidine triad diadenosine triphosphatase	Homo sapiens	60-64
10580296-0	1999	c-Fos expression in the myenteric plexus, spinal cord and brainstem following injection of formalin in the rat colonic wall.	Formaldehyde	91-99	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-5
10580296-1	1999	Fos expression induced by injection of dilute formalin (50 microl, 5% in physiological saline) into the colonic wall was examined in the myenteric plexus, lumbosacral spinal cord and brainstem of the rat.	Formaldehyde	46-54	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-3
10580296-2	1999	The aims of this study were (i) to determine whether neurons in these regions express Fos in response to the injection of formalin into the colon and (ii) to examine whether administration of an alpha 2 adrenoceptor agonist modulates Fos expression.	Formaldehyde	122-130	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	86-89
10580296-5	1999	The number of Fos immunoreactive nuclei significantly increased in both myenteric neurons and enteric glia after the injection of formalin.	Formaldehyde	130-138	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	14-17
10580296-6	1999	Similarly, Fos immunoreactive neuronal nuclei were significantly increased in the spinal cord, area postrema and nucleus of the solitary tract after the injection of formalin.	Formaldehyde	166-174	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	11-14
10580296-9	1999	These data show that injection of formalin in the colonic wall results in Fos expression in myenteric neurons and enteric glia, and neurons in the spinal cord and brainstem.	Formaldehyde	34-42	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	74-77
11130958-0	1999	c-Fos expression in the myenteric plexus, spinal cord and brainstem following injection of formalin in the rat colonic wall.	Formaldehyde	91-99	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-5
11130958-1	1999	Fos expression induced by injection of dilute formalin (50 microl, 5% in physiological saline) into the colonic wall was examined in the myenteric plexus, lumbosacral spinal cord and brainstem of the rat.	Formaldehyde	46-54	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-3
11130958-2	1999	The aims of this study were (i) to determine whether neurons in these regions express Fos in response to the injection of formalin into the colon and (ii) to examine whether administration of an alpha 2 adrenoceptor agonist modulates Fos expression.	Formaldehyde	122-130	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	86-89
11130958-5	1999	The number of Fos immunoreactive nuclei significantly increased in both myenteric neurons and enteric glia after the injection of formalin.	Formaldehyde	130-138	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	14-17
11130958-6	1999	Similarly, Fos immunoreactive neuronal nuclei were significantly increased in the spinal cord, area postrema and nucleus of the solitary tract after the injection of formalin.	Formaldehyde	166-174	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	11-14
11130958-9	1999	These data show that injection of formalin in the colonic wall results in Fos expression in myenteric neurons and enteric glia, and neurons in the spinal cord and brainstem.	Formaldehyde	34-42	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	74-77
10565681-5	1999	In this present study, the investigators conducted a reverse transcription (RT)-polymerase chain reaction (PCR) assay to detect the COL1A1-PDGFB fusion transcripts using archival formalin-fixed, paraffin-embedded tumor specimens from 12 patients with DFSP.	Formaldehyde	179-187	collagen type I alpha 1 chain	Homo sapiens	132-138
10565681-5	1999	In this present study, the investigators conducted a reverse transcription (RT)-polymerase chain reaction (PCR) assay to detect the COL1A1-PDGFB fusion transcripts using archival formalin-fixed, paraffin-embedded tumor specimens from 12 patients with DFSP.	Formaldehyde	179-187	platelet derived growth factor subunit B	Homo sapiens	139-144
10497785-1	1999	The deamination of methylamine and aminoacetone by semicarbazide-sensitive amine oxidase (SSAO) produces formaldehyde and methylglyoxal, respectively, which have been presumed to be involved in diabetic complications.	Formaldehyde	105-117	amine oxidase, copper containing 3	Rattus norvegicus	51-88
10427139-5	1999	Sequence analysis of exons 5 through 8 of p53 was performed on subcloned PCR-amplified DNA, extracted from formalin-fixed, paraffin-embedded tumors.	Formaldehyde	107-115	tumor protein p53	Homo sapiens	42-45
10497785-1	1999	The deamination of methylamine and aminoacetone by semicarbazide-sensitive amine oxidase (SSAO) produces formaldehyde and methylglyoxal, respectively, which have been presumed to be involved in diabetic complications.	Formaldehyde	105-117	amine oxidase, copper containing 3	Rattus norvegicus	90-94
10497785-6	1999	A potent selective SSAO inhibitor, (E)-2-(4-fluorophenethyl)-3-fluoroallylamine hydrochloride (MDL-72974A), reduced the formation of formaldehyde, methylglyoxal, and malondialdehyde.	Formaldehyde	133-145	amine oxidase, copper containing 3	Rattus norvegicus	19-23
10451500-5	1999	The antibody permitted chymase-containing mast cells to be detected in formalin-fixed tissues, and the numbers identified were similar to those in tissues fixed with Carnoy"s or ethanol fixatives.	Formaldehyde	71-79	chymase 1	Homo sapiens	23-30
10606186-4	1999	Immunohistochemical staining for mutant p53 was performed on formalin fixed transurethral resection specimens of 31 patients who underwent radical cystectomy.	Formaldehyde	61-69	tumor protein p53	Homo sapiens	40-43
10438372-1	1999	In order to characterize the expression of the viral interleukin-6 (vIL-6) homologue in various human herpesvirus 8 (HHV-8)-associated diseases, in situ hybridization and immunohistochemistry were applied to formalin-fixed specimens.	Formaldehyde	208-216	K2	Human gammaherpesvirus 8	53-66
10438372-1	1999	In order to characterize the expression of the viral interleukin-6 (vIL-6) homologue in various human herpesvirus 8 (HHV-8)-associated diseases, in situ hybridization and immunohistochemistry were applied to formalin-fixed specimens.	Formaldehyde	208-216	K2	Human gammaherpesvirus 8	68-73
10497900-0	1999	Opioidergic and adrenergic modulation of formalin-evoked spinal c-fos mRNA expression and nocifensive behavior in the rat.	Formaldehyde	41-49	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	64-69
10544390-6	1999	In nonstressed mice, the injection of beta-EP produced a reduction in formalin-induced paw-licking in the second phase.	Formaldehyde	70-78	pro-opiomelanocortin-alpha	Mus musculus	38-45
11245094-0	1999	Effects of intra-hippocampal injection of interleukin-2 on pain threshold and formaldehyde-induced substance P-like immunoreactivity in periaqueductal gray and spinal cord.	Formaldehyde	78-90	interleukin 2	Rattus norvegicus	42-55
10497900-2	1999	We determine whether formalin-induced spinal c-fos mRNA expression (Northern blotting) correlates with nocifensive behavior following pretreatment with morphine, the alpha2-adrenoceptor agonist dexmedetomidine, or their respective antagonists naloxone and atipamezole.	Formaldehyde	21-29	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	45-50
10497900-3	1999	Both opiate and alpha2-adrenoceptor agonists reduced formalin-induced c-fos gene transcription and nocifensive behavior via their cognate receptors.	Formaldehyde	53-61	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	70-75
10497900-4	1999	Unexpectedly, blockade of either the opiate or alpha2-adrenergic receptors, alone, caused an increase in formalin-evoked c-fos mRNA; while blocking the opiate receptor had no effect on formalin-induced behavior, alpha2-adrenoceptor block had an analgesic effect, indicating discordance between c-fos message transcription and nocifensive behavior.	Formaldehyde	105-113	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	121-126
10497900-4	1999	Unexpectedly, blockade of either the opiate or alpha2-adrenergic receptors, alone, caused an increase in formalin-evoked c-fos mRNA; while blocking the opiate receptor had no effect on formalin-induced behavior, alpha2-adrenoceptor block had an analgesic effect, indicating discordance between c-fos message transcription and nocifensive behavior.	Formaldehyde	105-113	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	294-299
10497900-5	1999	We concluded that the formalin-induced spinal c-fos signal was a poor predictor of the behavioral response to pharmacological manipulation of pain processing pathways.	Formaldehyde	22-30	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	46-51
10452682-2	1999	In this study, we investigated the expression of cyclin D1 in the formalin-fixed and paraffin-embedded human hepatocellular carcinoma (HCC) tissues of 25 patients, using monoclonal antibody 5D4 raised against cyclin D1.	Formaldehyde	66-74	cyclin D1	Homo sapiens	49-58
10463576-3	1999	By applying an allele-specific in situ hybridization technique to formalin-fixed thin sections, we show that the parental IGF2 alleles can be differentially expressed, not only in Wilms" tumors, but also in nephrogenic rests (which represent premalignant lesions) of Wilms" tumor patients.	Formaldehyde	66-74	insulin like growth factor 2	Homo sapiens	122-126
10409754-6	1999	Additionally, using the technique of formaldehyde cross-linking coupled with restriction endonuclease cleavage and ligation-mediated PCR, we were able to map the polymerase density on the promoter of HSP82.	Formaldehyde	37-49	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	200-205
10414986-3	1999	In electrophysiological experiments on single dorsal horn neurons in vivo, the excitatory responses to subcutaneous formalin injection (50 microliter, 2.5%) were attenuated by subsequent intravenously administration of the NK-1 receptor antagonist CP-96,345 (0.5 mg/kg; n = 8), given 35-40 min after formalin, but not by the inactive enantiomer CP-96,344 (0.5 mg/kg; n = 9).	Formaldehyde	116-124	tachykinin receptor 1	Rattus norvegicus	223-236
10414986-3	1999	In electrophysiological experiments on single dorsal horn neurons in vivo, the excitatory responses to subcutaneous formalin injection (50 microliter, 2.5%) were attenuated by subsequent intravenously administration of the NK-1 receptor antagonist CP-96,345 (0.5 mg/kg; n = 8), given 35-40 min after formalin, but not by the inactive enantiomer CP-96,344 (0.5 mg/kg; n = 9).	Formaldehyde	300-308	tachykinin receptor 1	Rattus norvegicus	223-236
10678109-3	1999	RESULTS: The increases of NOS-positive neurons, Fos, NOS/Fos double labelling neurons of the spinal dorsal horn and the PIR after formalin injection were markedly inhibited by intrathecal injecting (ith) Cor (0.5-1.5 U), which were obviously attenuated by L-arginine (Arg, 5-15 nmol, ith), the substrate of NOS.	Formaldehyde	130-138	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	57-60
10438655-1	1999	The carcinogenic potential of dichloromethane (DCM) has been linked to its metabolism to formaldehyde by glutathione-S-transferase theta 1 (GSTT1).	Formaldehyde	89-101	glutathione S-transferase theta 1	Homo sapiens	105-138
10438655-1	1999	The carcinogenic potential of dichloromethane (DCM) has been linked to its metabolism to formaldehyde by glutathione-S-transferase theta 1 (GSTT1).	Formaldehyde	89-101	glutathione S-transferase theta 1	Homo sapiens	140-145
10396291-8	1999	We analyzed Bcl-6 staining of formalin-fixed paraffin-embedded tissue from 72 indolent lymphomas including 31 grade I and II follicle center lymphomas (FCL).	Formaldehyde	30-38	BCL6 transcription repressor	Homo sapiens	12-17
10388649-3	1999	We tested the ability of an adjuvanted carrier (Iscomatrix) to help human antigen-presenting cells present formalin-killed influenza vaccine to human CD8(+) CTL clones in vitro and in vaccinated humans.	Formaldehyde	107-115	CD8a molecule	Homo sapiens	150-153
10373663-9	1999	PCNA immunostaining can be applied on a routine basis in formalin-fixed, paraffin-embedded samples of NSCLC to predict patient prognosis and thus to identify patients in need of additional postoperative therapies.	Formaldehyde	57-65	proliferating cell nuclear antigen	Homo sapiens	0-4
10444310-5	1999	Within 30 min, formalin elicited a four- to sixfold increase in plasma ACTH and corticosterone concentrations and intense Fos-like activity was seen in the superficial zones of the lumbar spinal cord ipsilateral to the side of the formalin injection.	Formaldehyde	15-23	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	122-125
10444310-5	1999	Within 30 min, formalin elicited a four- to sixfold increase in plasma ACTH and corticosterone concentrations and intense Fos-like activity was seen in the superficial zones of the lumbar spinal cord ipsilateral to the side of the formalin injection.	Formaldehyde	231-239	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	122-125
10444310-6	1999	In brainstem catecholaminergic neurones, the PVN, and midline thalamic nuclei, formalin-induced Fos-immunopositivity was equally present in the ipsi- and contralateral sides of the injection.	Formaldehyde	79-87	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	96-99
10600205-6	1999	The P69 protein appeared quite robust to formaldehyde treatment as measured by the same methods.	Formaldehyde	41-53	islet cell autoantigen 1	Homo sapiens	4-7
10358022-2	1999	Targeting of mouse alcohol dehydrogenase genes Adh1, Adh3, and Adh4 resulted in null mutant mice that all developed and reproduced apparently normally but differed markedly in clearance of ethanol and formaldehyde plus metabolism of retinol to the signaling molecule retinoic acid.	Formaldehyde	201-213	alcohol dehydrogenase 1 (class I)	Mus musculus	47-51
10358022-2	1999	Targeting of mouse alcohol dehydrogenase genes Adh1, Adh3, and Adh4 resulted in null mutant mice that all developed and reproduced apparently normally but differed markedly in clearance of ethanol and formaldehyde plus metabolism of retinol to the signaling molecule retinoic acid.	Formaldehyde	201-213	alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide	Mus musculus	53-57
10358022-8	1999	Thus, Adh1 and Adh4 demonstrate overlapping functions in ethanol and retinol metabolism in vivo, whereas Adh3 plays no role with these substrates but instead functions in formaldehyde metabolism.	Formaldehyde	171-183	alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide	Mus musculus	105-109
10483067-2	1999	MATERIALS AND METHODS: The expression of p53 and MDM2 proteins was determined immunohistochemically in 51 formalin-fixed, paraffin embedded specimens of odontogenic cysts and tumours.	Formaldehyde	106-114	tumor protein p53	Homo sapiens	41-44
10366647-8	1999	Thus behavioral nociceptive responses induced by intraplantar formalin and by intraplantar carageenan are significantly attenuated by trkB-IgG.	Formaldehyde	62-70	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	134-138
10748551-6	1999	Since FB1 and FB21 can be used with formalin-fixed paraffin-embedded tissue sections, they are useful for diagnosis of B cell lymphoma or thyroid carcinoma.	Formaldehyde	36-44	TCF3 fusion partner	Homo sapiens	6-9
10374264-5	1999	Taking advantage of the reactivity of mAb PP2-150 with formalin-fixed, paraffin-embedded material, a series of human carcinomas (n = 37) has also been analyzed.	Formaldehyde	55-63	neuropeptide Y receptor Y6 (pseudogene)	Homo sapiens	42-45
10367777-5	1999	Formalin-fixed paraffin sections were immunostained with MAb MIB-1, which stains cells in the proliferating phase of the cell cycle.	Formaldehyde	0-8	MIB E3 ubiquitin protein ligase 1	Homo sapiens	61-66
11529112-6	1999	The tape could be used to detect down to 0.08 ppm (World Health Organization standard) of formaldehyde with a sampling time of 30 min and a flow rate of 100 mL min-1.	Formaldehyde	90-102	CD59 molecule (CD59 blood group)	Homo sapiens	160-165
10495105-10	1999	For IAPP, studies in IAPP-deficient mice support the notion that IAPP is a pronociceptive peptide, because these mutant mice display a reduced nociceptive response when challenged with formalin.	Formaldehyde	185-193	islet amyloid polypeptide	Mus musculus	21-25
10366466-3	1999	The expression of VEGF was immunohistochemically evaluated by polyclonal antibody anti-VEGF (Santa Cruz, CA, dilution 1:100) on formalin-fixed paraffin-embedded tissue.	Formaldehyde	128-136	vascular endothelial growth factor A	Homo sapiens	18-22
10374774-2	1999	WT1 allelic integrity was examined by loss of heterozygosity (LOH) studies in formalin-fixed, paraffin-embedded (FFPE) ductal carcinoma in situ (DCIS, n = 20) and fresh frozen primary invasive breast carcinomas (n = 24).	Formaldehyde	78-86	WT1 transcription factor	Homo sapiens	0-3
10382576-2	1999	This study examines the distribution of the transforming growth factor-beta1 containing (TGF-beta1+) cells in formalin-fixed and paraffin-embedded gingival specimens from 11 patients with chronic marginal periodontitis and 7 persons with healthy gingiva.	Formaldehyde	110-118	transforming growth factor beta 1	Homo sapiens	44-76
10382576-2	1999	This study examines the distribution of the transforming growth factor-beta1 containing (TGF-beta1+) cells in formalin-fixed and paraffin-embedded gingival specimens from 11 patients with chronic marginal periodontitis and 7 persons with healthy gingiva.	Formaldehyde	110-118	transforming growth factor beta 1	Homo sapiens	89-98
10326701-4	1999	Expression of VEGF and MMP2 was evaluated immunohistochemically by polyclonal antibody anti-VEGF (dilution, 1:100) and affinity purified, rabbit anti-MMP2, formalin fixed, paraffin embedded tissue.	Formaldehyde	156-164	vascular endothelial growth factor A	Homo sapiens	14-18
10470136-2	1999	Immunohistochemical techniques were used to demonstrate the presence of growth hormone receptors in 126 formalin-fixed, paraffin-embedded melanocytic tumours comprising melanocytic naevi, superficial spreading melanoma, nodular melanoma, lentigo maligna melanoma and metastatic melanomas.	Formaldehyde	104-112	growth hormone 1	Homo sapiens	72-86
10350552-8	1999	Spinal sections from both formalin and zymosan treated animals exhibited microglial and astrocytic activation and increased Interleukin-1beta immunoreactivity at 1 and 6 h, respectively.	Formaldehyde	26-34	interleukin 1 beta	Rattus norvegicus	124-141
10350552-9	1999	Spinal glial activation and upregulation of Interleukin-1beta appear to parallel the development and maintenance of zymosan and formalin-induced mechanical allodynia.	Formaldehyde	128-136	interleukin 1 beta	Rattus norvegicus	44-61
10328435-1	1999	OBJECTIVE: To determine the estrogen receptor (ER) content of canine mammary gland tumors by use of immunohistochemical (IHC) examination of formalin-fixed sections.	Formaldehyde	141-149	estrogen receptor 1	Canis lupus familiaris	47-49
10328435-3	1999	PROCEDURE: ER were detected in formalin-fixed tissues, using an avidin-biotin alkaline phosphatase IHC assay and were quantified on fresh-frozen tumor samples, using a modified dextran-coated charcoal (DCC) assay.	Formaldehyde	31-39	estrogen receptor 1	Canis lupus familiaris	11-13
10216136-1	1999	Receptor-mediated endocytosis (RME) by a scavenger receptor on sinusoidal liver endothelial cells (LECs) for formaldehyde-treated bovine serum albumin (f-Alb) has previously been shown to be impaired following chronic ethanol consumption.	Formaldehyde	109-121	albumin	Rattus norvegicus	154-157
10225833-7	1999	By immunohistochemistry four monoclonal antibodies detected bovine coronavirus and elk coronavirus in formalin-fixed intestinal tissues.	Formaldehyde	102-110	potassium voltage-gated channel subfamily H member 8	Homo sapiens	83-86
10334533-3	1999	PATIENTS AND METHODS: ER status was evaluated in 1,982 primary breast cancers by IHC on formalin-fixed paraffin-embedded tissue sections, using antibody 6F11 and standard methodology.	Formaldehyde	88-96	estrogen receptor 1	Homo sapiens	22-24
10340566-7	1999	Formaldehyde treatment of casein increased ADG (65, 74, 55, and 91 g/d; P = .03) and clean fleece production (P &lt; .01; 14.1, 17.3, 15.0, and 18.4 g/d for UC-Control, TC-Control, UC-bST, and TC-bST, respectively), with no effect of bST during the 8-wk period of treatment or for the 8 wk thereafter (P &gt; .10).	Formaldehyde	0-12	ADG	Bos taurus	43-46
10353503-7	1999	The number of Fos stained cells in the dorsal horn of the spinal cord, induced by the formalin treatment, was decreased significantly by the 3.0 mg dose of morphine at all three ages.	Formaldehyde	86-94	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	14-17
10349985-4	1999	bcl-2 and p53 protein expression were demonstrated by immunohistochemical methods, using formalin-fixed, paraffin-embedded biopsy tissues.	Formaldehyde	89-97	BCL2 apoptosis regulator	Homo sapiens	0-5
10349985-4	1999	bcl-2 and p53 protein expression were demonstrated by immunohistochemical methods, using formalin-fixed, paraffin-embedded biopsy tissues.	Formaldehyde	89-97	tumor protein p53	Homo sapiens	10-13
10621852-9	1999	For the formalin-fixed tissue specimens, 62% (13/21) and 90% (19/21) expressed p53 and PCNA, respectively.	Formaldehyde	8-16	tumor protein p53	Homo sapiens	79-82
10621852-9	1999	For the formalin-fixed tissue specimens, 62% (13/21) and 90% (19/21) expressed p53 and PCNA, respectively.	Formaldehyde	8-16	proliferating cell nuclear antigen	Homo sapiens	87-91
10320002-4	1999	In the rats which were subcutaneously injected with formalin into the upper and lower lips, c-fos protein (Fos) was found in PPD-LI neurons which were labeled with a retrograde tracer injected into the thalamic regions.	Formaldehyde	52-60	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	92-105
10224325-9	1999	In contrast, DNA fragments induced by formaldehyde peaked below 1 Mbp, implicating activation of DNA-degrading enzymes.	Formaldehyde	38-50	myelin basic protein	Homo sapiens	66-69
10323258-8	1999	In the formalin test, nociceptin/orphanin FQ also produced a marked and dose-dependent antinociceptive effect on the first-phase response, but not the second phase-response, in both diabetic and non-diabetic mice.	Formaldehyde	7-15	prepronociceptin	Mus musculus	33-44
10321494-3	1999	In the formalin test, a model of tonic pain, Ts65Dn mice showed depressed sensitivity to nociception during the early and late phases.	Formaldehyde	7-15	reciprocal translocation, Chr 16, cytogenetic band C3-4; and Chr 17, cytogenetic band A2, Davisson 65	Mus musculus	45-51
10320002-4	1999	In the rats which were subcutaneously injected with formalin into the upper and lower lips, c-fos protein (Fos) was found in PPD-LI neurons which were labeled with a retrograde tracer injected into the thalamic regions.	Formaldehyde	52-60	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	107-110
10560479-9	1999	All formalin-fixed tissue specimens that were determined to positively express c-erbB-2 were also found to be positive on the alcohol-fixed smears.	Formaldehyde	4-12	erb-b2 receptor tyrosine kinase 2	Homo sapiens	79-87
10560479-10	1999	CONCLUSION: The incidence of c-erbB-2 expression in fresh cytologic material is significantly higher (P &lt; .05) than in formalin-fixed, paraffin-embedded tissue.	Formaldehyde	122-130	erb-b2 receptor tyrosine kinase 2	Homo sapiens	29-37
10398123-8	1999	The definition of a specific caspase cleavage site in CK18 as a neo-epitope can be used for quantification of apoptotic epithelial cells with immunocytochemical techniques and is applicable to both fresh and formalin-fixed material.	Formaldehyde	208-216	keratin 18	Homo sapiens	54-58
10234450-0	1999	Non-isotopic in situ hybridization of CD44 transcript in formalin-fixed paraffin-embedded sections.	Formaldehyde	57-65	CD44 molecule (Indian blood group)	Homo sapiens	38-42
10234450-1	1999	We established a protocol for the non-isotopic in situ detection of adhesion molecule CD44 messenger RNA (mRNA) in archival formalin-fixed paraffin-embedded sections of human surgical materials.	Formaldehyde	124-132	CD44 molecule (Indian blood group)	Homo sapiens	86-90
10208461-6	1999	MATERIALS AND METHODS: Formalin-fixed paraffin sections were used for immunostaining of Bcl-6.	Formaldehyde	23-31	BCL6 transcription repressor	Homo sapiens	88-93
10201006-9	1999	Nonradioactive in situ hybridization studies on sections from formalin-fixed and paraffin-embedded, normally concentrating kidneys showed strong expression of BGT, SMIT, and AR mRNAs in interstitial and collecting duct cells of the papilla, whereas expression of SDH mRNA was much weaker in both cell types.	Formaldehyde	62-70	solute carrier family 5 member 3	Homo sapiens	164-168
10201006-9	1999	Nonradioactive in situ hybridization studies on sections from formalin-fixed and paraffin-embedded, normally concentrating kidneys showed strong expression of BGT, SMIT, and AR mRNAs in interstitial and collecting duct cells of the papilla, whereas expression of SDH mRNA was much weaker in both cell types.	Formaldehyde	62-70	aldo-keto reductase family 1 member B	Homo sapiens	174-176
10078919-5	1999	Formalin-fixed paraffin-embedded tissues from randomly selected patients (22 histologically normal parathyroid glands, 33 cases of hyperplasia, 43 adenomas, and 17 carcinomas) were analyzed for expression of p27 by immunostaining.	Formaldehyde	0-8	cyclin dependent kinase inhibitor 1B	Homo sapiens	208-211
10188946-4	1999	One and two days after formalin injection, the immunostaining of cell bodies and neuropil of the AMPA receptor subunits GluR1 and GluR2/3 was markedly decreased in the ipsilateral superficial laminae of the subnucleus caudalis compared to the contralateral side.	Formaldehyde	23-31	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	120-125
10188946-4	1999	One and two days after formalin injection, the immunostaining of cell bodies and neuropil of the AMPA receptor subunits GluR1 and GluR2/3 was markedly decreased in the ipsilateral superficial laminae of the subnucleus caudalis compared to the contralateral side.	Formaldehyde	23-31	glutamate ionotropic receptor AMPA type subunit 2	Rattus norvegicus	130-135
10188946-6	1999	The down-regulation of AMPA GluR1 and GluR2/3 was no longer detectable in the subnucleus caudalis three days after formalin injection.	Formaldehyde	115-123	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	28-33
10188946-6	1999	The down-regulation of AMPA GluR1 and GluR2/3 was no longer detectable in the subnucleus caudalis three days after formalin injection.	Formaldehyde	115-123	glutamate ionotropic receptor AMPA type subunit 2	Rattus norvegicus	38-43
10082309-5	1999	A formaldehyde-methanol fixation procedure was optimized for retention of p105 within mitotic cells by analytic titration of formaldehyde.	Formaldehyde	2-14	nuclear factor kappa B subunit 1	Homo sapiens	74-78
10350186-8	1999	Under the same conditions, however, GST-mediated conversion of DCM to formaldehyde was lower in cell-free extracts of the transconjugant expressing the rat GSTT1 than in the corresponding strain expressing the bacterial DCM dehalogenase.	Formaldehyde	70-82	glutathione S-transferase theta 1	Rattus norvegicus	156-161
10188904-2	1999	We have investigated mutation in the PTEN gene by direct sequence analysis of PCR products amplified from samples microdissected from 19 low grade (WHO Grade I and II) and 27 high grade (WHO grade III and IV) archival, formalin-fixed, paraffin-embedded gliomas.	Formaldehyde	219-227	phosphatase and tensin homolog	Homo sapiens	37-41
10082309-5	1999	A formaldehyde-methanol fixation procedure was optimized for retention of p105 within mitotic cells by analytic titration of formaldehyde.	Formaldehyde	125-137	nuclear factor kappa B subunit 1	Homo sapiens	74-78
10082309-12	1999	A permeabilization-sensitive antigen (p105), previously requiring formaldehyde/detergent-fixed cell preparations, was shown to work equally well with formaldehyde/ methanol fixation.	Formaldehyde	66-78	nuclear factor kappa B subunit 1	Homo sapiens	38-42
10051214-4	1999	However, in the deeper layers of the spinal cord (V-X), there was no such correlation, and stimulation of joint nociceptors and formalin-induced inflammation produced the greatest proportion of Fos/neurokinin-1 co-localization, suggesting a particular role for substance P in the mediation of joint pain and inflammatory hyperalgesia.	Formaldehyde	128-136	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	194-197
10217560-6	1999	In both cases, a reverse transcription-polymerase chain reaction using RNA extracted from formalin-fixed, paraffin-embedded tissues detected SYT-SSX fusion gene transcripts, which are characteristic of synovial sarcoma.	Formaldehyde	90-98	synaptotagmin 1	Homo sapiens	141-144
10217560-6	1999	In both cases, a reverse transcription-polymerase chain reaction using RNA extracted from formalin-fixed, paraffin-embedded tissues detected SYT-SSX fusion gene transcripts, which are characteristic of synovial sarcoma.	Formaldehyde	90-98	SSX family member 2B	Homo sapiens	145-148
11240754-4	1999	We examined p53 accumulation in formalin-fixed, paraffin-embedded archival sections in 19 cases previously shown to have mutations in the p53 gene and performed semi-quantitative analysis of the intensity of staining and relative density of positive cells and stromal and glandular elements.	Formaldehyde	32-40	tumor protein p53	Homo sapiens	12-15
10086736-8	1999	Immunohistochemical staining of formalin-fixed, paraffin-embedded tissue for p16 confirmed these results, as all tumours with alterations of CDKN2A were p16 immunonegative.	Formaldehyde	32-40	cyclin dependent kinase inhibitor 2A	Homo sapiens	77-80
10051217-3	1999	Previously, we reported that formalin (5%, 0.05 ml, s.c.) injection into a hindpaw evoked, in the CA1 field, a "signal-to-noise processing", i.e. a selective excitation of a few pyramidal cells with high spontaneous extracellular activity against a background of widespread pyramidal cell suppression accompanied by an increase in period of rhythmic slow activity.	Formaldehyde	29-37	carbonic anhydrase 1	Rattus norvegicus	98-101
10051217-0	1999	Morphine reversed formalin-induced CA1 pyramidal cell suppression via an effect on septohippocampal neural processing.	Formaldehyde	18-26	carbonic anhydrase 1	Rattus norvegicus	35-38
10051217-7	1999	This dose, administered as a pretreatment, also truncated CA1 pyramidal cell suppression or excitation to a formalin injection.	Formaldehyde	108-116	carbonic anhydrase 1	Rattus norvegicus	58-61
10100930-0	1999	Distinct effect of intracerebroventricular and intrathecal injections of nociceptin/orphanin FQ in the rat formalin test.	Formaldehyde	107-115	prepronociceptin	Rattus norvegicus	73-83
10051217-9	1999	Such an effect was observed in a time-frame parallel to the decline in the period of formalin injection-induced field CA1 rhythmic slow activity.	Formaldehyde	85-93	carbonic anhydrase 1	Rattus norvegicus	118-121
10452091-0	1999	Effect of tetrahydropalmatine analogs on Fos expression induced by formalin-pain.	Formaldehyde	67-75	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	41-44
10452091-1	1999	AIM: To study the effect of tetrahydropalmatine (THP) analogs on Fos protein expression induced by formalin-pain and elucidate analgesic mechanism of THP analogs.	Formaldehyde	99-107	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	65-68
10100930-2	1999	The present study was designed to investigate the effect of nociceptin/OFQ on pain response and opioid analgesia in the rat formalin test.	Formaldehyde	124-132	prepronociceptin	Rattus norvegicus	60-70
10100930-5	1999	On the other hand, intrathecal injection of nociceptin/OFQ (0.1, 1 and 5 microg) reduced the pain response in the formalin test.	Formaldehyde	114-122	prepronociceptin	Rattus norvegicus	44-54
10100930-6	1999	In conclusion, nociceptin/OFQ potentiated formalin-induced pain response and antagonized opioid analgesia in the rat brain but inhibited pain response in the spinal cord.	Formaldehyde	42-50	prepronociceptin	Rattus norvegicus	15-25
9972767-0	1999	Pre- versus postinjury effects of intravenous GABAergic anesthetics on formalin-induced Fos immunoreactivity in the rat spinal cord.	Formaldehyde	71-79	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	88-91
9972767-15	1999	We measured spinal Fos protein after rats received anesthetics before versus after a formalin injection.	Formaldehyde	85-93	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	19-22
10207610-0	1999	Activity of O6-methylguanine DNA methyltransferase in mononuclear blood cells of formaldehyde-exposed medical students.	Formaldehyde	81-93	O-6-methylguanine-DNA methyltransferase	Homo sapiens	12-50
10050790-3	1999	METHODS: Using an immunohistochemical method, we assessed for cyclin D1 expression in 8 breast papillomas and 6 papillary carcinomas, all of which were formalin fixed, routinely processed, and paraffin embedded.	Formaldehyde	152-160	cyclin D1	Homo sapiens	62-71
10207610-1	1999	A recent study reported that exposure of student embalmers in Cincinnati to high concentrations of formaldehyde (2 mg/m3) reduced the activity of the DNA repair protein O6-methylguanine DNA methyltransferase (MGMT).	Formaldehyde	99-111	O-6-methylguanine-DNA methyltransferase	Homo sapiens	169-207
10207610-1	1999	A recent study reported that exposure of student embalmers in Cincinnati to high concentrations of formaldehyde (2 mg/m3) reduced the activity of the DNA repair protein O6-methylguanine DNA methyltransferase (MGMT).	Formaldehyde	99-111	O-6-methylguanine-DNA methyltransferase	Homo sapiens	209-213
10207610-3	1999	Thus, we examined whether formaldehyde exposure of 57 medical students during their anatomy course at two different Universities in Germany influenced MGMT activity in mononuclear blood cells.	Formaldehyde	26-38	O-6-methylguanine-DNA methyltransferase	Homo sapiens	151-155
11972177-2	1999	The results showed that subcutaneous injection of formalin in the right hindpaw increased c-fos-like immunoreactivity (FLI), somatostatin-like immunoreactivity (Som-LI), Som-LI/FLI and perprosomatostatin mRNA (PPS-mRNA) in neurones of right spinal dorsal horn and significantly enhanced pain intensity rating.	Formaldehyde	50-58	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	90-95
10092405-1	1999	Formaldehyde (F) binds human serum albumin (HSA) covalently, giving rise to a molecular adduct F-HSA having the F as hapten.	Formaldehyde	0-12	albumin	Homo sapiens	29-59
9949353-6	1999	To explore the role played by cyclin D1 in the pathogenesis of thyroid papillary carcinoma, we have quantitated, by computerized image analysis, the immunohistochemical expression of cyclin D1 in formalin-fixed, paraffin-embedded tissue from 35 conventional papillary carcinomas of the thyroid and correlated the results with established clinicopathologic parameters and available survival data.	Formaldehyde	196-204	cyclin D1	Homo sapiens	183-192
10233491-0	1999	Prostate specific antigen is detectable in formalin-fixed semen.	Formaldehyde	43-51	kallikrein related peptidase 3	Homo sapiens	0-25
10233704-10	1999	As the anti-LSP1 reagent used in the present study recognizes a formalin-resistant epitope it should be of considerable value in the diagnosis of routinely fixed material.	Formaldehyde	64-72	lymphocyte specific protein 1	Homo sapiens	12-16
10204476-5	1999	Tonsillar application of whole cells of formalin-killed Streptococcus sobrinus induced anti-S. sobrinus IgA in saliva.	Formaldehyde	40-48	IGA	Ovis aries	104-107
11972177-2	1999	The results showed that subcutaneous injection of formalin in the right hindpaw increased c-fos-like immunoreactivity (FLI), somatostatin-like immunoreactivity (Som-LI), Som-LI/FLI and perprosomatostatin mRNA (PPS-mRNA) in neurones of right spinal dorsal horn and significantly enhanced pain intensity rating.	Formaldehyde	50-58	somatostatin	Rattus norvegicus	125-137
10529510-9	1999	IgH gene rearrangement in formalin-fixed, paraffin-embedded specimens was determined by polymerase chain reaction in 11 patients with chronic gastritis.	Formaldehyde	26-34	immunoglobulin heavy locus	Homo sapiens	0-3
10437171-0	1999	[Effect of corticotrophin on formaldehyde-induced somatostatin of spinal cord in rats].	Formaldehyde	29-41	somatostatin	Rattus norvegicus	50-62
10437171-1	1999	AIM: To study the effect of corticotrophin (Cor) on somatostatin (Som) and its synthesis in spinal dorsal horn induced by formaldehyde in rats.	Formaldehyde	122-134	somatostatin	Rattus norvegicus	52-64
10437171-1	1999	AIM: To study the effect of corticotrophin (Cor) on somatostatin (Som) and its synthesis in spinal dorsal horn induced by formaldehyde in rats.	Formaldehyde	122-134	somatostatin	Rattus norvegicus	66-69
10437171-7	1999	inhibited the formaldehyde-evoked FLI, Som-LI, Som-LI/FLI, and PPS-mRNA of spinal cord in a dose-dependent manner.	Formaldehyde	14-26	somatostatin	Rattus norvegicus	47-50
10437171-10	1999	CONCLUSION: The formaldehyde-evoked c-fos expression, Som, and Som synthesis of spinal cord were suppressed by Cor through the serotonin receptor of raphe nuclei.	Formaldehyde	16-28	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	36-41
10327586-6	1999	Formaldehyde also reacts with the lysine residues of beta 2 GPI, but does not expose the epitope.	Formaldehyde	0-12	apolipoprotein H	Homo sapiens	53-63
10216500-4	1999	We developed an immunohistochemical assay allowing us to evaluate the bax expression in formalin fixed and paraffin embedded lung cancer tissues to investigate bax expression in a cohort of 55 patients affected by non-small cell lung cancer.	Formaldehyde	88-96	BCL2 associated X, apoptosis regulator	Homo sapiens	70-73
10051711-8	1999	RESULTS: DNCB-alpha and formaldehyde-activated LNCs produced high levels of the TH1-type cytokine interferon gamma, but little of the TH2-type products interleukins 4 and 10.	Formaldehyde	24-36	heart and neural crest derivatives expressed 2	Mus musculus	134-137
9918708-4	1999	In sympathectomized animals, pretreatment with angiotensin II inhibited the increase of peripheral blood flow following formalin injection when compared to animals pretreated with saline or hydralazine.	Formaldehyde	120-128	angiotensinogen	Homo sapiens	47-61
9987016-4	1999	The number of superficial (laminae I-II) and deep (laminae III-VI) spinal dorsal horn cells expressing the c-fos proto-oncogene 2 h after subcutaneous injection of formalin was reduced by 34% and 50%, respectively, in animals with an ipsilateral DRt lesion as compared to non-lesioned rats.	Formaldehyde	164-172	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	107-112
10228798-4	1999	METHODOLOGY: The expression of E-cadherin was evaluated in 57 formalin-fixed, paraffin-embedded specimens of colorectal cancer by immunohistochemistry.	Formaldehyde	62-70	cadherin 1	Homo sapiens	31-41
10405826-7	1999	Perfusion with saline prior to formalin resulted in a rapid decrease in the detectability of p53, indicating rapid degradation of this protein under these conditions.	Formaldehyde	31-39	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	93-96
10405826-8	1999	We conclude that rapid fixation by formalin perfusion increases the detectability of p53 by immunohistochemical staining.	Formaldehyde	35-43	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	85-88
9950155-4	1999	We examined TTF-1 expression in 51 TCs, 9 ACs, 8 LCNECs, and 21 SCLCs with use of formalin-fixed material and heat-induced epitope retrieval.	Formaldehyde	82-90	NK2 homeobox 1	Homo sapiens	12-17
9952108-6	1999	BB1 antibody was effective in identifying basophils in sections of mixed cells or in tissues after fixation with ethanol, Carnoy"s solution, or formalin.	Formaldehyde	144-152	neuromedin B receptor	Homo sapiens	0-3
10576589-4	1999	The present study examined the effect of polyamine deprivation on pain-related behaviors and spinal c-fos expression evoked in the formalin test presumed to better reflect clinical pain, using morphine as analgesia control.	Formaldehyde	131-139	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	100-105
9920154-7	1999	The progression and severity of diabetic complications such as angiopathy may be exacerbated by cytotoxic metabolites (e.g., formaldehyde and hydrogen peroxide) formed by SSAO.	Formaldehyde	125-137	amine oxidase copper containing 2	Homo sapiens	171-175
9916928-1	1999	Expression of protein kinase C (PKC) isoenzymes -alpha, -beta, -delta, -epsilon, -gamma, -iota, -lambda, -mu, -theta, and -zeta, and of their common receptor for activated C-kinase (RACK)-1, was determined immunohistochemically using specific antibodies in formalin-fixed and paraffin-embedded specimens of early prostatic adenocarcinomas (n = 23) obtained at radical prostatectomy.	Formaldehyde	257-265	protein kinase C alpha	Homo sapiens	32-35
9950165-11	1999	Accordingly, CENP-F seems to be a useful proliferation marker for formalin-fixed and paraffin-embedded material.	Formaldehyde	66-74	centromere protein F	Homo sapiens	13-19
10430499-9	1999	Neurokinin-1 receptor messenger RNA levels were, however, significantly increased in hindpaw tissues inflamed by formalin for 6 h. These results indicate that the plasticity of neurokinin-1 receptor gene expression in non-neuronal peripheral cells could regulate sensitivity to substance P in a manner similar to that in the spinal cord dorsal horn.	Formaldehyde	113-121	tachykinin receptor 1	Rattus norvegicus	0-21
10430469-1	1999	A majority (24/32) of the extracellularly recorded dorsal hippocampus field CA1 putative GABAergic interneurons were excited in conjunction with theta activation on formalin injection (5%, 0.05 ml, s.c. into right hind-paw) in urethane (1.0 g/kg, i.p.	Formaldehyde	165-173	carbonic anhydrase 1	Rattus norvegicus	76-79
10430474-0	1999	Detection and quantification of hippocampal synaptophysin messenger RNA in schizophrenia using autoclaved, formalin-fixed, paraffin wax-embedded sections.	Formaldehyde	107-115	synaptophysin	Homo sapiens	44-57
10430499-9	1999	Neurokinin-1 receptor messenger RNA levels were, however, significantly increased in hindpaw tissues inflamed by formalin for 6 h. These results indicate that the plasticity of neurokinin-1 receptor gene expression in non-neuronal peripheral cells could regulate sensitivity to substance P in a manner similar to that in the spinal cord dorsal horn.	Formaldehyde	113-121	tachykinin receptor 1	Rattus norvegicus	177-198
10714205-5	1999	In gastric carcinoma specimens known to express mutant E-cadherin messenger RNA these monoclonal antibodies target exclusively tumor cells in routine formalin fixed and paraffin embedded material from biopsies, primary tumors and lymph node metastases.	Formaldehyde	150-158	cadherin 1	Homo sapiens	55-65
10079373-3	1999	Therefore, to assess the alterations in the conjoint expression of Rb and p53 proteins in formalin fixed paraffin embedded sections, 64 astrocytic tumors were studied (16 astrocytomas,7 gemistocytic astrocytomas, 19 anaplastic astrocytomas and 22 glioblastomas) using the avidin biotin immunoperoxidase technique.	Formaldehyde	90-98	tumor protein p53	Homo sapiens	74-77
10461064-4	1999	c-myc amplification in tumor tissue was determined using a differential polymerase chain reaction, a useful procedure for the evaluation of gene amplification in archival formalin-fixed paraffin-embedded tissues, in comparison with a dopamine D2 receptor gene.	Formaldehyde	171-179	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	0-5
10631715-3	1999	The monoclonal antibodies E9 (anti-MT), DO-7 (which reacts with a denaturation-resistant epitope in wild-type and mutant p53) and PC10 (anti-PCNA) on formalin-fixed, paraffin-embedded tissue were used employing the immunoperoxidase (ABC) method.	Formaldehyde	150-158	proliferating cell nuclear antigen	Homo sapiens	141-145
11397270-1	1999	The expression of p53 protein was investigated in eight formalin-fixed, paraffin-embedded conjunctival squamous cell carcinomas of five horses and one cow, dog and cat each by an immunohistochemical procedure in order to evaluate protein overexpression.	Formaldehyde	56-64	tumor protein p53	Equus caballus	18-21
9846986-8	1998	This assay for cyclin D1 expression, designed for formalin-fixed, paraffin-embedded tissue, was a very sensitive and specific marker for mantle-cell lymphoma.	Formaldehyde	50-58	cyclin D1	Homo sapiens	15-24
9846971-2	1998	In this study, we conducted a reverse transcription-polymerase chain reaction-based assay to detect the SYT-SSX fusion gene transcripts using archival formalin-fixed, paraffin-embedded tumor specimens from a series of 32 synovial sarcoma cases including 6 tumors found in unusual anatomical sites.	Formaldehyde	151-159	synaptotagmin 1	Homo sapiens	104-107
9824606-11	1998	Antibodies which are effective in formalin fixed, paraffin wax embedded sections are useful for the identification of MMPs and TIMPs in diagnostic specimens.	Formaldehyde	34-42	matrix metallopeptidase 1	Homo sapiens	118-122
9846971-2	1998	In this study, we conducted a reverse transcription-polymerase chain reaction-based assay to detect the SYT-SSX fusion gene transcripts using archival formalin-fixed, paraffin-embedded tumor specimens from a series of 32 synovial sarcoma cases including 6 tumors found in unusual anatomical sites.	Formaldehyde	151-159	SSX family member 2	Homo sapiens	108-111
9886570-3	1998	Exons 5-8 of the p53 gene were examined for mutations by the polymerase chain reaction-single strand conformation polymorphism technique and DNA sequencing, using DNA from formalin-fixed paraffin-embedded tissues.	Formaldehyde	172-180	tumor protein p53	Homo sapiens	17-20
9839129-7	1998	MIC-2 antibody was applied retrospectively to formalin-fixed cell block material and destained alcohol-fixed and air-dried cytologic preparations.	Formaldehyde	46-54	CD99 molecule (Xg blood group)	Homo sapiens	0-5
9839129-13	1998	We conclude that MIC-2 is a sensitive and specific marker for the PNET/ES group of neoplasms in specimens from formalin-fixed cell block, air-dried, and alcohol-fixed cytologic material and is useful in the differential diagnosis of small blue cell tumors.	Formaldehyde	111-119	CD99 molecule (Xg blood group)	Homo sapiens	17-22
9804904-7	1998	The number of neurons expressing PPD mRNA dramatically increased in the superficial dorsal horn ipsilateral to the formalin injection in the control group compared to the contralateral side.	Formaldehyde	115-123	prodynorphin	Rattus norvegicus	33-36
10066099-2	1998	The nuclear proliferation antigen Ki-67 was visualized by means of the monoclonal antibody MIB1 on formalin fixed and paraffin embedded tissue.	Formaldehyde	99-107	MIB E3 ubiquitin protein ligase 1	Homo sapiens	91-95
9857953-2	1998	The presence of DNIC was revealed by the reduction in the levels of Fos-like immunoreactivity that are normally induced by a standardized primary pinch stimulus when this stimulus was accompanied by a concurrent noxious stimulus (formalin) to a heterotopic body part.	Formaldehyde	230-238	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	68-71
9820167-3	1998	HAP1 expression levels were determined after staining of formalin-fixed paraffin-embedded tumour sections with a rabbit antiserum raised against recombinant HAP1.	Formaldehyde	57-65	huntingtin associated protein 1	Homo sapiens	0-4
9860279-8	1998	We found scattered CD30+ cells in only one of six formalin-fixed paraffin-embedded acute atopic dermatitis biopsies, but in all of the respective snap-frozen specimens, possibly because CD30 expression on atopic dermatitis infiltrating cells is weak and sensitive to formalin fixation and paraffin embedding.	Formaldehyde	50-58	TNF receptor superfamily member 8	Homo sapiens	19-23
9860279-8	1998	We found scattered CD30+ cells in only one of six formalin-fixed paraffin-embedded acute atopic dermatitis biopsies, but in all of the respective snap-frozen specimens, possibly because CD30 expression on atopic dermatitis infiltrating cells is weak and sensitive to formalin fixation and paraffin embedding.	Formaldehyde	267-275	TNF receptor superfamily member 8	Homo sapiens	19-23
9823984-3	1998	An immunohistochemical technique was used to evaluate the association between expression of c-erbB3 and clinical parameters and tumour markers such as epidermal growth factor receptor (EGFR), c-erbB2, cathepsin-D and p53 in archival formalin-fixed paraffin-embedded tumour tissues.	Formaldehyde	233-241	erb-b2 receptor tyrosine kinase 3	Homo sapiens	92-99
9851689-7	1998	The antibodies were used to detect, by immunohistochemistry, activated MMP-9 in formalin-fixed, wax-embedded sections from a series of oesophageal cancer cases previously shown to contain MMP-9.	Formaldehyde	80-88	matrix metallopeptidase 9	Homo sapiens	71-76
9851689-9	1998	As the antibodies are effective in immunohistochemistry on formalin-fixed, wax-embedded sections, they should prove useful for the detection of activated MMP-9 in various disease processes.	Formaldehyde	59-67	matrix metallopeptidase 9	Homo sapiens	154-159
9891464-2	1998	We evaluated E-cadherin expression immunohistochemically in 43 formalin-fixed, paraffin-embedded specimens of pancreatic cancer and investigated its relationship to histopathological features.	Formaldehyde	63-71	cadherin 1	Homo sapiens	13-23
9813391-3	1998	First it was screened immunohistochemically against a wide range of formalin-fixed normal and neoplastic human tissues and showed widespread binding to mucin throughout the gastro-intestinal tract, in both normal and malignant tissues.	Formaldehyde	68-76	LOC100508689	Homo sapiens	152-157
10437133-0	1998	NMDA receptors mediating Fos expression in rat spinal cord induced by subcutaneous injection of formalin.	Formaldehyde	96-104	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	25-28
9951940-3	1998	METHODOLOGY: The expression of E-cadherin was evaluated in 83 formalin-fixed, paraffin-embedded specimens of gastric cancer by immunohistochemistry.	Formaldehyde	62-70	cadherin 1	Homo sapiens	31-41
9811645-8	1998	These and other experiments (e.g., those to determine the expression of the gene and the growth ability of the das1Delta strain on media containing methylamine or choline as a nitrogen source) suggested that DAS1 is involved in assimilation rather than dissimilation or detoxification of formaldehyde in the cells.	Formaldehyde	288-300	SCF ubiquitin ligase complex subunit DAS1	Saccharomyces cerevisiae S288C	208-212
10437133-4	1998	RESULTS: Two hours after s.c. formalin, Fos-like immunoreactive (FLI) neurons were distributed mainly in medial part of the lamina I and the outer lamina II of the ipsilateral dorsal horn.	Formaldehyde	30-38	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	40-43
9781601-3	1998	C-fos protein expression was evaluated using archival formalin-fixed, paraffin-embedded tumor tissue, and an automated immunoperoxidase histochemical technique.	Formaldehyde	54-62	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	0-5
9784802-4	1998	METHOD OF STUDY: Mast cells were identified by immunohistochemistry using monoclonal antibody against mast cell tryptase on formalin-fixed, paraffin-embedded sections.	Formaldehyde	124-132	tryptase delta 1	Homo sapiens	102-120
9827660-7	1998	As a next step, we developed a technique for TRH mRNA in situ hybridization using a [35S] CTP-labeled TRH cRNA antisense probe in formalin-fixed paraffin-embedded sections.	Formaldehyde	130-138	thyrotropin releasing hormone	Homo sapiens	45-48
9769117-1	1998	HLA-A2402-restricted and carcinoembryonic-antigen(CEA)-specific cytotoxic T lymphocytes (CTL) were induced by culturing human peripheral blood mononuclear cells (PBMC) on formalin-fixed autologous adhesive PBMC that had been loaded with CEA-bound latex beads.	Formaldehyde	171-179	CEA cell adhesion molecule 3	Homo sapiens	25-54
9769117-1	1998	HLA-A2402-restricted and carcinoembryonic-antigen(CEA)-specific cytotoxic T lymphocytes (CTL) were induced by culturing human peripheral blood mononuclear cells (PBMC) on formalin-fixed autologous adhesive PBMC that had been loaded with CEA-bound latex beads.	Formaldehyde	171-179	CEA cell adhesion molecule 3	Homo sapiens	50-53
9796724-8	1998	We used anti-CD23 (BU38) in formalin-fixed, paraffin-embedded tissue.	Formaldehyde	28-36	Fc epsilon receptor II	Homo sapiens	13-17
9788259-6	1998	These results were confirmed by immunohistochemistry, but a relatively higher frequency of c-Met expression was detected in adenomatous goiters (25%), follicular adenoma (44%) and papillary carcinoma (100%) using formalin-fixed and paraffin-embedded materials.	Formaldehyde	213-221	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	91-96
11367759-0	1998	[Effects of morphine on the formalin induced IL-2R beta mRNA expression of rat hippocampus].	Formaldehyde	28-36	interleukin 2 receptor subunit beta	Rattus norvegicus	45-55
11367759-1	1998	Using method of in situ hybridization, the effects of subcutaneous injection (s.c.) of formalin (For) into one hindpaw (hyperalgesia) on IL-2R beta mRNA expression in hippocampus (Hip) were studied.	Formaldehyde	87-95	interleukin 2 receptor subunit beta	Rattus norvegicus	137-147
9773930-0	1998	Advantages of immunostaining over DNA analysis using PCR amplification to detect p53 abnormality in long-term formalin-fixed tissues of human colorectal carcinomas.	Formaldehyde	110-118	tumor protein p53	Homo sapiens	81-84
9773930-1	1998	To study the appropriate period for formalin fixation in order to detect p53 abnormalities in formalin-fixed tissue, we used seven surgically resected human colorectal cancer specimens.	Formaldehyde	36-44	tumor protein p53	Homo sapiens	73-76
9773930-1	1998	To study the appropriate period for formalin fixation in order to detect p53 abnormalities in formalin-fixed tissue, we used seven surgically resected human colorectal cancer specimens.	Formaldehyde	94-102	tumor protein p53	Homo sapiens	73-76
9773930-6	1998	PCR amplification for p53 at exon 8 and K-ras at codon 12 was successful until 1 day and 2 weeks, respectively, of formalin-fixation for the specimens of all seven cases.	Formaldehyde	115-123	tumor protein p53	Homo sapiens	22-25
9773930-6	1998	PCR amplification for p53 at exon 8 and K-ras at codon 12 was successful until 1 day and 2 weeks, respectively, of formalin-fixation for the specimens of all seven cases.	Formaldehyde	115-123	KRAS proto-oncogene, GTPase	Homo sapiens	40-45
9773930-9	1998	These results suggest that to detect p53 abnormality in specimens that have been formalin-fixed for long periods, immunohistochemical staining may have advantages over DNA analysis with PCR amplification.	Formaldehyde	81-89	tumor protein p53	Homo sapiens	37-40
9827660-7	1998	As a next step, we developed a technique for TRH mRNA in situ hybridization using a [35S] CTP-labeled TRH cRNA antisense probe in formalin-fixed paraffin-embedded sections.	Formaldehyde	130-138	thyrotropin releasing hormone	Homo sapiens	102-105
9733749-6	1998	Second, we used an in vivo cross-linking procedure to covalently link Mcm proteins and ORC2 to DNA by short exposure of intact HeLa cells to formaldehyde.	Formaldehyde	141-153	origin recognition complex subunit 2	Homo sapiens	87-91
11155673-2	1998	METHODS: nm23 oncoprotein expression was measured by immunohistochemical staining using formalin fixed, paraffin embedded sections of 39 surgically resected osteosarcomas and was compared with Ki-67 expression, histological findings and early metastasis.	Formaldehyde	88-96	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	9-13
9736039-5	1998	Formalin-fixed paraffin-embedded specimens from matched samples of normal-appearing prostate tissue, benign prostatic hyperplasia, high-grade prostatic intraepithelial neoplasia, primary adenocarcinomas, and pelvic lymph node metastases were evaluated by comparative immunohistochemistry against p27Kip1.	Formaldehyde	0-8	cyclin dependent kinase inhibitor 1B	Homo sapiens	296-303
9787897-0	1998	Quantitative TLC determination of formaldehyde in hard tissues of teeth.	Formaldehyde	34-46	lipocalin 1	Homo sapiens	13-16
9787897-1	1998	Levels of formaldehyde, which is formed within cells as an indispensable part of biological processes, have been determined by means of TLC in hard tissues of human teeth, with and without pathological changes.	Formaldehyde	10-22	lipocalin 1	Homo sapiens	136-139
9712192-7	1998	The findings support the idea that nicotine can enhance SSAO/methylamine-mediated increase of formaldehyde and oxidative stress and this could in part contribute the adverse effect of health associated with smoking.	Formaldehyde	94-106	amine oxidase, copper containing 3	Mus musculus	56-60
9863492-5	1998	An in situ hybridisation technique was adapted to localise and measure semiquantitatively type I procollagen mRNA in formalin fixed, paraffin wax embedded sections, using an 35S labelled cRNA probe specific for the alpha 1 chain of rat type I procollagen.	Formaldehyde	117-125	collagen type I alpha 2 chain	Homo sapiens	90-108
9785199-3	1998	Formalin-fixed paraffin-embedded tissue was used for avidin-biotin immunocytochemical localization of IGFBPs utilizing standard methodology.	Formaldehyde	0-8	insulin-like growth factor binding protein 1	Mus musculus	102-108
9758365-5	1998	Immunohistochemical analysis of seprase expression in 41 formalin-fixed and paraffin-embedded specimens of human breast tissue revealed preferential immunoreactivity with the malignant cells of IDC (27 cases).	Formaldehyde	57-65	fibroblast activation protein alpha	Homo sapiens	32-39
9893638-0	1998	Expression of MDR1 mRNA and encoding P-glycoprotein in archival formalin-fixed paraffin-embedded gall bladder cancer tissues.	Formaldehyde	64-72	ATP binding cassette subfamily B member 1	Homo sapiens	14-18
9662651-6	1998	Formalin-fixed human muscle displayed a CD77 reaction with highest accumulation of reaction product at the periphery of the fibers.	Formaldehyde	0-8	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	40-44
9881874-4	1998	Intradermal injection of capsaicin or formalin also increased Fos-positive neurons.	Formaldehyde	38-46	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	62-65
9881874-5	1998	Capsaicin- or formalin-induced Fos expression was reduced in both cases by pretreatment of capsazepine, but to a much lesser extent for formalin.	Formaldehyde	14-22	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	31-34
9881874-5	1998	Capsaicin- or formalin-induced Fos expression was reduced in both cases by pretreatment of capsazepine, but to a much lesser extent for formalin.	Formaldehyde	136-144	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	31-34
9706936-5	1998	A peripheral delta-opioid receptor agonist, [D-Pen(2,5)] enkephalin (DPDPE), suppressed only Phase 2 of the formalin test.	Formaldehyde	108-116	proenkephalin	Rattus norvegicus	57-67
9792280-4	1998	We have applied cyanogen bromide cleavage, a technique used routinely for fragmenting proteins for sequencing experiments, to solubilize transferrin polypeptides and glycopolypeptides from formalin-fixed, paraffin wax-embedded rat liver.	Formaldehyde	189-197	transferrin	Rattus norvegicus	137-148
9725567-2	1998	CD44 expression was characterised in a closely matched series of oral carcinomas with and without metastases in both frozen and formalin-fixed tissue and correlated with behaviour and histological grading parameters.	Formaldehyde	128-136	CD44 molecule (Indian blood group)	Homo sapiens	0-4
9893752-0	1998	Immunohistochemical retrieval of the principal HIV antigens p24, gp41, and gp120 in formalin fixed tissue: an investigation using HIV infected lymphoblasts and postmortem brain tissue from AIDS cases.	Formaldehyde	84-92	transmembrane p24 trafficking protein 2	Homo sapiens	60-63
9893752-0	1998	Immunohistochemical retrieval of the principal HIV antigens p24, gp41, and gp120 in formalin fixed tissue: an investigation using HIV infected lymphoblasts and postmortem brain tissue from AIDS cases.	Formaldehyde	84-92	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	75-80
9764809-0	1998	Melan A/MART-1 immunoreactivity in formalin-fixed paraffin-embedded primary and metastatic melanoma: frequency and distribution.	Formaldehyde	35-43	melan-A	Homo sapiens	0-7
9764809-0	1998	Melan A/MART-1 immunoreactivity in formalin-fixed paraffin-embedded primary and metastatic melanoma: frequency and distribution.	Formaldehyde	35-43	melan-A	Homo sapiens	8-14
9893752-2	1998	This procedure greatly improved the detection rate of the p24 and gp41 HIV surface antigens in formalin fixed, paraffin wax embedded, HIV positive central nervous system (CNS) tissue while restricting staining to areas of the CNS showing evidence of neuropathology.	Formaldehyde	95-103	transmembrane p24 trafficking protein 2	Homo sapiens	58-61
10343973-14	1998	These results indicated that dilute formalin preserved Hsc/Hsp70 and Ub antigenicity well, and that the proteins had similar distributions in human and rat brains, despite the extended postmortem delay in fixation of the former.	Formaldehyde	36-44	fucosyltransferase 1 (H blood group)	Homo sapiens	55-58
9681947-1	1998	The number and distribution of Fos-like-immunoreactive neurons in different supraspinal brain areas induced by formalin injection into one hindpaw was estimated in rats with transected dorsal half of the spinal cord at the thoracic level in an attempt to avoid most of the descending modulatory actions.	Formaldehyde	111-119	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	31-34
10343973-14	1998	These results indicated that dilute formalin preserved Hsc/Hsp70 and Ub antigenicity well, and that the proteins had similar distributions in human and rat brains, despite the extended postmortem delay in fixation of the former.	Formaldehyde	36-44	heat shock protein family A (Hsp70) member 4	Homo sapiens	59-64
9617388-4	1998	Job assignments with TWAs above the worksite"s median TWA8 were called high formaldehyde exposed (HFE).	Formaldehyde	76-88	homeostatic iron regulator	Homo sapiens	98-101
9736404-3	1998	The aim of this study was to investigate the expression of p16 and Rb proteins by immunohistochemistry using 98 formalin-fixed and paraffin-embedded samples of various cervical neoplastic lesions.	Formaldehyde	112-120	cyclin dependent kinase inhibitor 2A	Homo sapiens	59-62
11324543-0	1998	[Neurokinin-1 receptor mediated formalin-induced c-fos expression in the rat spinal cord].	Formaldehyde	32-40	tachykinin receptor 1	Rattus norvegicus	1-22
11324543-0	1998	[Neurokinin-1 receptor mediated formalin-induced c-fos expression in the rat spinal cord].	Formaldehyde	32-40	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	49-54
11324543-1	1998	In the present work, the effects of tachykinin receptor antagonists on formalin-induced c-fos expression in the rat spinal cord were studied by a combination of immunocytochemical and neuropharmacological methods.	Formaldehyde	71-79	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	88-93
11324543-2	1998	Formalin injected into a hindpaw of rat only resulted in c-fos expression in the ipsilateral dorsal horn neurons of the spinal cord.	Formaldehyde	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	57-62
11324543-6	1998	Our results indicated that NK-1 receptor mediated formalin-induced c-fos expression in the spinal cord, suggesting NK-1 receptor might play an important role in the spinal transmission of nociceptive messages.	Formaldehyde	50-58	tachykinin receptor 1	Rattus norvegicus	27-40
11324543-6	1998	Our results indicated that NK-1 receptor mediated formalin-induced c-fos expression in the spinal cord, suggesting NK-1 receptor might play an important role in the spinal transmission of nociceptive messages.	Formaldehyde	50-58	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	67-72
11324543-6	1998	Our results indicated that NK-1 receptor mediated formalin-induced c-fos expression in the spinal cord, suggesting NK-1 receptor might play an important role in the spinal transmission of nociceptive messages.	Formaldehyde	50-58	tachykinin receptor 1	Rattus norvegicus	115-128
9754735-8	1998	In cirrhotics CH2O was correlated positively with serum albumin and cholinesterase and negatively with the retention rate of indocyanine green at 15 min.	Formaldehyde	14-18	butyrylcholinesterase	Homo sapiens	68-82
9754735-9	1998	Basal SP was negatively correlated with CH2O (r= -0.71: P &lt; 0.001) and MAP (r= -0.56; P &lt; 0.005).	Formaldehyde	40-44	tachykinin precursor 1	Homo sapiens	6-8
9737788-7	1998	ILK may be a sensitive and specific immunohistochemical marker and useful for the positive identification of ES and PNET in formalin-fixed, paraffin-embedded tissue sections.	Formaldehyde	124-132	integrin linked kinase	Homo sapiens	0-3
9678509-5	1998	It is shown for the first time that archival, formalin-fixed, paraffin-embedded sural nerve biopsy samples can be used for establishing the diagnosis of PMP-22 diseases, i.e., HMSN Ia and HNPP, by PCR amplification of the region coding for the PMP-22 gene.	Formaldehyde	46-54	peripheral myelin protein 22	Homo sapiens	153-159
9678509-5	1998	It is shown for the first time that archival, formalin-fixed, paraffin-embedded sural nerve biopsy samples can be used for establishing the diagnosis of PMP-22 diseases, i.e., HMSN Ia and HNPP, by PCR amplification of the region coding for the PMP-22 gene.	Formaldehyde	46-54	peripheral myelin protein 22	Homo sapiens	244-250
9681686-2	1998	In the present study we assessed uPA-R distribution in formalin-fixed, paraffin-embedded breast cancer specimens (n=50) and benign lesions (n=10) by immunohistochemistry employing a newly developed polyclonal chicken antibody to uPA-R (pAb HU277) in parallel with established monoclonal antibody (mAb) 3936 to uPA-R.	Formaldehyde	55-63	plasminogen activator, urokinase	Homo sapiens	33-36
9655287-4	1998	Histopathologic/genetic analysis of p53 was performed on formalin fixed, paraffin embedded tissues.	Formaldehyde	57-65	tumor protein p53	Homo sapiens	36-39
9698472-2	1998	Immunostaining for p53 protein was performed on formalin-fixed, paraffin-embedded sections from 158 patients with verified uterine sarcomas using monoclonal p53 antibody (DO-1).	Formaldehyde	48-56	tumor protein p53	Homo sapiens	19-22
9635540-2	1998	This study used MIB-1 monoclonal antibody, a proliferative marker that can be used in formalin fixed paraffin embedded tissues, to study nonpilocytic pediatric astrocytoma.	Formaldehyde	86-94	MIB E3 ubiquitin protein ligase 1	Homo sapiens	16-21
9688183-0	1998	Detection of the SYT-SSX fusion transcripts in formaldehyde-fixed, paraffin-embedded tissue: a reverse transcription polymerase chain reaction amplification assay useful in the diagnosis of synovial sarcoma.	Formaldehyde	47-59	synaptotagmin 1	Homo sapiens	17-20
9688183-0	1998	Detection of the SYT-SSX fusion transcripts in formaldehyde-fixed, paraffin-embedded tissue: a reverse transcription polymerase chain reaction amplification assay useful in the diagnosis of synovial sarcoma.	Formaldehyde	47-59	SSX family member 2	Homo sapiens	21-24
9823779-2	1998	Formalin-fixed, paraffin-embedded sections from 34 patients with cervical adenocarcinoma or adenosquamous carcinoma were immunostained with monoclonal antibody MIB1, expressed in proliferating cells, and anti-nm23 antibody, reacts with metastasis suppression gene products.	Formaldehyde	0-8	MIB E3 ubiquitin protein ligase 1	Homo sapiens	160-164
9622083-11	1998	Analysis of the clinical significance of the differential expression of the scFv 61-defined determinant in melanoma lesions will be facilitated by its reactivity with formalin-fixed melanoma lesions.	Formaldehyde	167-175	immunglobulin heavy chain variable region	Homo sapiens	76-80
9626464-3	1998	The expression of p53, bcl-2, thymidylate synthase (TS), glutathione S-transferase pi (GST-pi), and vascular endothelial growth factor (VEGF) in the formalin-fixed biopsy samples of primary tumors before chemotherapy was examined immunohistochemically.	Formaldehyde	149-157	vascular endothelial growth factor A	Homo sapiens	100-134
9626464-3	1998	The expression of p53, bcl-2, thymidylate synthase (TS), glutathione S-transferase pi (GST-pi), and vascular endothelial growth factor (VEGF) in the formalin-fixed biopsy samples of primary tumors before chemotherapy was examined immunohistochemically.	Formaldehyde	149-157	vascular endothelial growth factor A	Homo sapiens	136-140
17040786-4	1998	Here, Elisabeth Herniou, Auriol Pearce and Tim Littlewood describe some of the advances and pitfalls associated with retrieving DNA from formalin-fixed helminth material and suggest just some of the new ways that parasitologists can tap into these resources.	Formaldehyde	137-145	Rho guanine nucleotide exchange factor 5	Homo sapiens	43-46
17040786-4	1998	Here, Elisabeth Herniou, Auriol Pearce and Tim Littlewood describe some of the advances and pitfalls associated with retrieving DNA from formalin-fixed helminth material and suggest just some of the new ways that parasitologists can tap into these resources.	Formaldehyde	137-145	nuclear RNA export factor 1	Homo sapiens	233-236
10375794-0	1998	[Effect of corticotropin on formalin-evoked c-fos expression of spinal cord and receptors analysis in rat].	Formaldehyde	28-36	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	44-49
10375794-1	1998	AIM: To study the effect of corticotropin (Cor) on c-fos expression induced by formalin in spinal cord of rat and the role of receptors.	Formaldehyde	79-87	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	51-56
10375794-3	1998	RESULTS: Cor inhibited the formalin-evoked c-fos expression in rat spinal cord in a dose-dependent manner.	Formaldehyde	27-35	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	43-48
10375794-6	1998	CONCLUSION: The formalin-evoked c-fos expression of rat spinal cord was suppressed by Cor through the alpha-adrenergic receptors, opiate receptors and calcium, but no relation to adrenal glands.	Formaldehyde	16-24	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	32-37
9626345-7	1998	Immunohistochemical analyses of formalin-fixed paraffin-embedded sections of tissues with specific antibodies revealed a prevalent cytoplasmic cyclin E staining in the thyroid tissues analyzed.	Formaldehyde	32-40	cyclin E1	Rattus norvegicus	143-151
9650699-1	1998	The expression of c-fos protein was studied in formalin-fixed, paraffin-embedded sections of 11 compound Spitz nevi (SNs), 16 ordinary compound melanocytic nevi (MNs), and 17 malignant melanomas (MMs) using monoclonal antibody MAB1283 and an immunoperoxidase technique.	Formaldehyde	47-55	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	18-23
9626464-3	1998	The expression of p53, bcl-2, thymidylate synthase (TS), glutathione S-transferase pi (GST-pi), and vascular endothelial growth factor (VEGF) in the formalin-fixed biopsy samples of primary tumors before chemotherapy was examined immunohistochemically.	Formaldehyde	149-157	tumor protein p53	Homo sapiens	18-21
9626464-3	1998	The expression of p53, bcl-2, thymidylate synthase (TS), glutathione S-transferase pi (GST-pi), and vascular endothelial growth factor (VEGF) in the formalin-fixed biopsy samples of primary tumors before chemotherapy was examined immunohistochemically.	Formaldehyde	149-157	thymidylate synthetase	Homo sapiens	30-50
9649223-12	1998	The identified antigens catalase and alpha-enolase can partly explain the ANCA fluorescence on ethanol-fixed and formaldehyde-fixed granulocytes in patients with PSC.	Formaldehyde	113-125	catalase	Homo sapiens	24-32
9649223-12	1998	The identified antigens catalase and alpha-enolase can partly explain the ANCA fluorescence on ethanol-fixed and formaldehyde-fixed granulocytes in patients with PSC.	Formaldehyde	113-125	enolase 1	Homo sapiens	37-50
9654458-2	1998	Here, high concentrations (up to 32%) of bovine serum albumin (BSA) were reacted with formaldehyde (1-20%) and glutaraldehyde (0.5-4%).	Formaldehyde	86-98	albumin	Homo sapiens	48-61
9836068-7	1998	This method is applicable to DNA from fresh frozen tissues, and, after the TcR beta rearrangement of a patient"s malignant T-cell clone has been identified by the screening PCR, DNA can also be detected in follow-up formalin-fixed paraffin-embedded samples by the J beta-specific PCR with high sensitivity and specificity.	Formaldehyde	216-224	T cell receptor beta locus	Homo sapiens	75-83
9674881-2	1998	Immunohistochemical demonstration of PR in formalin fixed tissue has previously proved difficult, and heat pretreatment is considered necessary to retrieve the antigen.	Formaldehyde	43-51	progesterone receptor	Homo sapiens	37-39
9638703-3	1998	Immunohistochemical analysis with monoclonal antibodies to bcl-2 oncoprotein in formalin-fixed paraffin-embedded tissue sections revealed that severe epithelial dysplasias had a higher percentage of immunoreactivity than did mild and moderate dysplasias and squamous cell carcinomas.	Formaldehyde	80-88	BCL2 apoptosis regulator	Homo sapiens	59-64
11324567-4	1998	However, Sar-SP (10(-4) mol/L) or formalin did result in the expression of c-fos gene in the superficial laminae of the dorsal horn.	Formaldehyde	34-42	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	75-80
9665655-0	1998	Differential effect of selective cyclooxygenase-2 (COX-2) inhibitor NS 398 and diclofenac on formalin-induced nociception in the rat.	Formaldehyde	93-101	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	51-56
9665655-9	1998	Our results suggest that PGs mediating nociception in the formalin test of the rat are most likely produced via the COX-1 as well as COX-2 pathways.	Formaldehyde	58-66	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	116-121
9665655-9	1998	Our results suggest that PGs mediating nociception in the formalin test of the rat are most likely produced via the COX-1 as well as COX-2 pathways.	Formaldehyde	58-66	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	133-138
9703782-4	1998	SPF was determined by flow cytofluorometry, MIB1, p53, and HER-2/neu by immunohistochemistry in adjacent routinely formalin-fixed paraffin sections.	Formaldehyde	115-123	SEC14 like lipid binding 2	Homo sapiens	0-3
9797697-4	1998	Immunohistochemical expression of p53 protein was evaluated in formalin-fixed paraffin-embedded sections of CRC liver metastases using the monoclonal antibodies (MAbs) D01 and Pab 1801.	Formaldehyde	63-71	tumor protein p53	Homo sapiens	34-37
9708196-1	1998	This paper describes the results of immuno-histochemical staining for chicken mannan-binding lectin (MBL) in formalin-fixed tissue sections from non-infected chickens, and from chickens infected with infectious laryngotracheitis virus (ILTV) or infectious bursal disease virus (IBDV).	Formaldehyde	109-117	mannose binding lectin 2	Gallus gallus	78-99
9570628-3	1998	METHODS: A monoclonal antibody against the c-erbB-2 oncoprotein has been used immunocytochemically in a retrospective study of formalin-fixed, paraffin-embedded samples from 28 consecutive intestinal-type adenocarcinomas (ITACs) of the nose and paranasal sinuses.	Formaldehyde	127-135	erb-b2 receptor tyrosine kinase 2	Homo sapiens	43-51
9708196-1	1998	This paper describes the results of immuno-histochemical staining for chicken mannan-binding lectin (MBL) in formalin-fixed tissue sections from non-infected chickens, and from chickens infected with infectious laryngotracheitis virus (ILTV) or infectious bursal disease virus (IBDV).	Formaldehyde	109-117	mannose binding lectin 2	Gallus gallus	101-104
9605190-0	1998	Immunohistochemical detection of the DNA repair enzyme O6-methylguanine-DNA methyltransferase in formalin-fixed, paraffin-embedded astrocytomas.	Formaldehyde	97-105	O-6-methylguanine-DNA methyltransferase	Homo sapiens	55-93
9619566-2	1998	The aim of this study was to use immunohistochemistry to describe the vascular and glandular expression of integrin alpha(v)beta3 in formalin fixed, paraffin embedded endometrium obtained from women with (n = 29) and without (n = 24) endometriosis.	Formaldehyde	133-141	integrin subunit alpha V	Homo sapiens	107-129
10923439-2	1998	METHODS: Immunohistochemical method was used to detect and analyse the expression of P16 protein of CDKN2 suppressor gene of 76 cases in formalin-fixed, paraffin-embedded tissue specimens of human lung cancer.	Formaldehyde	137-145	cyclin dependent kinase inhibitor 2A	Homo sapiens	85-88
10923439-2	1998	METHODS: Immunohistochemical method was used to detect and analyse the expression of P16 protein of CDKN2 suppressor gene of 76 cases in formalin-fixed, paraffin-embedded tissue specimens of human lung cancer.	Formaldehyde	137-145	cyclin dependent kinase inhibitor 2A	Homo sapiens	100-105
9607618-9	1998	p53 mutant status was assessed immunohistochemically from sections of the formalin-fixed, paraffin-embedded pretreatment biopsy and the resected specimen.	Formaldehyde	74-82	tumor protein p53	Homo sapiens	0-3
9609668-0	1998	Simultaneous detection of p53 nuclear protein and chromosome aberrations on sections from formalin-fixed, paraffin-embedded breast cancer tissue.	Formaldehyde	90-98	tumor protein p53	Homo sapiens	26-29
9785008-2	1998	In this study, we conducted a nested reverse transcription-polymerase chain reaction (RT-PCR)-based assay to detect the TLS/FUS-CHOP fusion gene transcripts using archival formalin-fixed, paraffin-embedded tumor specimens.	Formaldehyde	172-180	FUS RNA binding protein	Homo sapiens	120-123
9609139-0	1998	Tyrosinase immunoreactivity in formalin-fixed, paraffin-embedded primary and metastatic melanoma: frequency and distribution.	Formaldehyde	31-39	tyrosinase	Homo sapiens	0-10
9610616-3	1998	Polymerase chain reaction (PCR) technology was used to examine the state of amplification of the proto-oncogene c-myc in formalin-fixed paraffin-embedded tissues.	Formaldehyde	121-129	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	97-117
9699184-4	1998	Expression of spr1 in 63 cases of formalin-fixed and paraffin-embedded human bronchogenic carcinoma was studied by immunohistochemical staining.	Formaldehyde	34-42	psoriasis susceptibility 1 candidate 2	Homo sapiens	14-18
9776820-4	1998	In addition, the results consistently demonstrated that at a yeast cell to PBMNC ratio of 20:1, formalin-preserved Malassezia, irrespective of serovar, growth phase or PBMNC donor, were capable of significantly (P&lt;0.05) decreasing the release of both immunochemical IL-6 and IL-1beta plus bioactive IL-1beta and TNF-alpha below that of unstimulated culture medium control values.	Formaldehyde	96-104	interleukin 6	Homo sapiens	269-273
9776820-4	1998	In addition, the results consistently demonstrated that at a yeast cell to PBMNC ratio of 20:1, formalin-preserved Malassezia, irrespective of serovar, growth phase or PBMNC donor, were capable of significantly (P&lt;0.05) decreasing the release of both immunochemical IL-6 and IL-1beta plus bioactive IL-1beta and TNF-alpha below that of unstimulated culture medium control values.	Formaldehyde	96-104	interleukin 1 beta	Homo sapiens	278-286
9776820-4	1998	In addition, the results consistently demonstrated that at a yeast cell to PBMNC ratio of 20:1, formalin-preserved Malassezia, irrespective of serovar, growth phase or PBMNC donor, were capable of significantly (P&lt;0.05) decreasing the release of both immunochemical IL-6 and IL-1beta plus bioactive IL-1beta and TNF-alpha below that of unstimulated culture medium control values.	Formaldehyde	96-104	interleukin 1 beta	Homo sapiens	302-310
9776820-4	1998	In addition, the results consistently demonstrated that at a yeast cell to PBMNC ratio of 20:1, formalin-preserved Malassezia, irrespective of serovar, growth phase or PBMNC donor, were capable of significantly (P&lt;0.05) decreasing the release of both immunochemical IL-6 and IL-1beta plus bioactive IL-1beta and TNF-alpha below that of unstimulated culture medium control values.	Formaldehyde	96-104	tumor necrosis factor	Homo sapiens	315-324
9548428-5	1998	We found statistically significant associations between the tumor cell proliferation rates measured by in vivo IdUrd labeling and MIB-1 expression in formalin-fixed paraffin-embedded tumors.	Formaldehyde	150-158	MIB E3 ubiquitin protein ligase 1	Homo sapiens	130-135
9713590-5	1998	Synthesis of p16/CDKN2 and pRb proteins was determined by immunohistochemistry in 19 specimens of formalin fixed, paraffin wax embedded tissues.	Formaldehyde	98-106	cyclin dependent kinase inhibitor 2A	Homo sapiens	13-16
9583772-1	1998	This is the first neural imaging study to use regional cerebral blood flow (rCBF) in an animal model to identify the patterns of forebrain nociceptive processing that occur during the early and late phase of the formalin test.	Formaldehyde	212-220	CCAAT/enhancer binding protein zeta	Rattus norvegicus	76-80
9583772-3	1998	Noxious formalin consistently produced detectable, well-localized and typically bilateral increases in rCBF within multiple forebrain structures, as well as the interpeduncular nucleus (Activation Index, AI = 66) and the midbrain periaqueductal gray (AI = 20).	Formaldehyde	8-16	CCAAT/enhancer binding protein zeta	Rattus norvegicus	103-107
10923484-2	1998	METHODS: NDPK(A) expression of formalin-fixed parafin-beded samples, which included 74 primary, 31 intraperitoneal and 18 retroperitoneal lymph node metastatic tumors, were examined by ABC immunohistochemisty in 74 patients with primary ovarian cancer.	Formaldehyde	31-39	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	9-16
9539247-5	1998	METHODS: Ret protein expression was evaluated immunohistochemically in formalin-fixed, paraffin-embedded whole-prostate sections.	Formaldehyde	71-79	ret proto-oncogene	Homo sapiens	9-12
9543489-0	1998	Improved method facilitates reliable APOE genotyping of genomic DNA extracted from formaldehyde-fixed pathology specimens.	Formaldehyde	83-95	apolipoprotein E	Homo sapiens	37-41
9541471-6	1998	Immunohistochemistry on formaldehyde-fixed paraffin-embedded normal human tissues revealed the presence of the class III beta-tubulin isotype in cell bodies and processes of neuronal cells in the peripheral and central nervous systems.	Formaldehyde	24-36	tubulin beta 3 class III	Homo sapiens	111-133
9520947-0	1998	Amplification of c-erbB-2 in gastric cancer: detection in formalin-fixed, paraffin-embedded tissue by fluorescence in situ hybridization.	Formaldehyde	58-66	erb-b2 receptor tyrosine kinase 2	Homo sapiens	17-25
9520949-5	1998	Mouse monoclonal antibody to c-Src protein was applied to 3-micron sections from formalin-fixed, paraffin-embedded tissues using the avidin-biotin-peroxidase method.	Formaldehyde	81-89	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	29-34
9532005-3	1998	We investigated GCDFP-15 expression in a large series of formalin-fixed, paraffin-embedded normal human adult and fetal tissues using the monoclonal antibody BRST-2.	Formaldehyde	57-65	prolactin induced protein	Homo sapiens	16-24
9543489-1	1998	Apolipoprotein E (APOE) genotyping of genomic DNA extracted from formaldehyde-fixed specimens is cumbersome: there is not only a low yield or failure of PCR amplification (presumably due to degradation of DNA in the formaldehyde-fixed and paraffin-embedded tissue), but the standard method also involves the separation of DNA fragments as small as 48, 72, 81 and 91 bp requiring high-yield PCR products.	Formaldehyde	65-77	apolipoprotein E	Homo sapiens	0-16
9543489-1	1998	Apolipoprotein E (APOE) genotyping of genomic DNA extracted from formaldehyde-fixed specimens is cumbersome: there is not only a low yield or failure of PCR amplification (presumably due to degradation of DNA in the formaldehyde-fixed and paraffin-embedded tissue), but the standard method also involves the separation of DNA fragments as small as 48, 72, 81 and 91 bp requiring high-yield PCR products.	Formaldehyde	65-77	apolipoprotein E	Homo sapiens	18-22
9543489-1	1998	Apolipoprotein E (APOE) genotyping of genomic DNA extracted from formaldehyde-fixed specimens is cumbersome: there is not only a low yield or failure of PCR amplification (presumably due to degradation of DNA in the formaldehyde-fixed and paraffin-embedded tissue), but the standard method also involves the separation of DNA fragments as small as 48, 72, 81 and 91 bp requiring high-yield PCR products.	Formaldehyde	216-228	apolipoprotein E	Homo sapiens	0-16
9543489-1	1998	Apolipoprotein E (APOE) genotyping of genomic DNA extracted from formaldehyde-fixed specimens is cumbersome: there is not only a low yield or failure of PCR amplification (presumably due to degradation of DNA in the formaldehyde-fixed and paraffin-embedded tissue), but the standard method also involves the separation of DNA fragments as small as 48, 72, 81 and 91 bp requiring high-yield PCR products.	Formaldehyde	216-228	apolipoprotein E	Homo sapiens	18-22
9466563-0	1998	Immunohistochemical detection of the human major vault protein LRP with two monoclonal antibodies in formalin-fixed, paraffin-embedded tissues.	Formaldehyde	101-109	major vault protein	Homo sapiens	43-62
9466563-0	1998	Immunohistochemical detection of the human major vault protein LRP with two monoclonal antibodies in formalin-fixed, paraffin-embedded tissues.	Formaldehyde	101-109	major vault protein	Homo sapiens	63-66
9466563-6	1998	Immunohistochemical studies with both MAbs in a panel of human multidrug resistant tumor cell lines, normal tissues, and colorectal tumors showed that LRP/MVP expression can be reliably detected after formalin-fixation and paraffm-embedding using overnight incubation at 4 degrees C with the primary MAbs at 5- to 10-fold higher concentrations (ie, 1 to 10 microg/ml) as currently used with frozen sections.	Formaldehyde	201-209	major vault protein	Homo sapiens	151-154
9646029-0	1998	Detection of tyrosinase mRNA in formalin-fixed, paraffin-embedded archival sections of melanoma, using the reverse transcriptase in situ polymerase chain reaction.	Formaldehyde	32-40	tyrosinase	Homo sapiens	13-23
9526028-1	1998	The localization and levels of expression of the calcium-binding protein calretinin (CR) in the human thalamus was studied with an in situ hybridization method applied to formalin-fixed postmortem material from normal individuals.	Formaldehyde	171-179	calbindin 2	Homo sapiens	73-83
9526028-10	1998	The data also demonstrate that the presence of CR gene transcript can easily be detected on formalin-fixed sections of the human brain.	Formaldehyde	92-100	calbindin 2	Homo sapiens	47-49
9452263-4	1998	METHODS: The authors analyzed Cg A mRNA in 20 cases of SCLC in formalin fixed, paraffin embedded tissue using a new, highly sensitive in situ hybridization method that was developed from the maximized immunohistochemistry (ImmunoMax) method.	Formaldehyde	63-71	chromogranin A	Homo sapiens	30-34
9646029-9	1998	It is possible to detect tyrosinase mRNA in formalin-fixed, paraffin-embedded tissue sections of melanoma, but the technique remains too demanding for routine application.	Formaldehyde	44-52	tyrosinase	Homo sapiens	25-35
9510369-6	1998	Both anti-LMP and anti-TAP mAb stained keratinocytes and infiltrating lymphocytes in frozen and formalin-fixed, paraffin embedded sections of normal skin in indirect immunoperoxidase reactions.	Formaldehyde	96-104	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	23-26
9572061-3	1998	After deamination by SSAO highly angiotoxic products are formed, methylglyoxal and formaldehyde, respectively.	Formaldehyde	83-95	amine oxidase copper containing 2	Homo sapiens	21-25
9447868-3	1998	METHODS: Formalin-induced nociception and Fos expression in the spinal cord, in response to a 50-microl injection of 2.5% formalin into the hind paw, were assessed in rats given an intrathecal injection of 50 microl 2% lidocaine by lumbar puncture between the L5 and L6 vertebrae, either 3 min before (pretreatment) or 5 min after (post-treatment) formalin injection.	Formaldehyde	122-130	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	42-45
9502224-4	1998	In the second part of the study, the formalin injection was carried out into two hindpaws of the rats with a sectioned dorsal quadrant at the thoracic spinal level, in these rats, there was a significant suppression of c-fos expression in the dorsal horn on the side with intact dorsal quadrant, reasonably owing to the preservation of the spinally descending inhibitory fibers from the supraspinal level; furthermore, this suppression could be canceled following i.t.	Formaldehyde	37-45	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	219-224
9502224-2	1998	The first part of the experiments showed that when formalin was injected into one hindpaw, the nociceptive c-fos expression in the lumbar dorsal horn ipsilateral to the injection was suppressed dose-dependently by intrathecal (i.t.)	Formaldehyde	51-59	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	107-112
10526979-8	1998	Formaldehyde modified hemoglobin was less susceptible to the action of cathepsin D.	Formaldehyde	0-12	cathepsin D	Homo sapiens	71-82
9447868-7	1998	On the other hand, the finding that the intrathecal injection of lidocaine after formalin treatment reduced Fos expression but not nociceptive responses indicates an uncoupling of the behavioral and Fos protein responses to formalin and suggests that changes in Fos expression may not be a good predictor of the ability of agents to produce preemptive analgesia.	Formaldehyde	81-89	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	108-111
9615190-7	1998	In conclusion, paraffin embedded and formalin fixed PC needle biopsies exhibit a higher diagnostic PCNA/Cyclin than Ki-67/MIB1 index for cases presenting differentiated features, whereas p120 nucleolar protein detection seems to be a suitable marker of poorer outcome of PC.	Formaldehyde	37-45	proliferating cell nuclear antigen	Homo sapiens	99-103
9467469-2	1998	MATERIALS AND METHODS: Apoptosis was detected by using the terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-biotin nick-end labelling (TUNEL) technique in 70 formalin-fixed and paraffin-embedded RCC specimens.	Formaldehyde	167-175	DNA nucleotidylexotransferase	Homo sapiens	59-96
9467469-2	1998	MATERIALS AND METHODS: Apoptosis was detected by using the terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-biotin nick-end labelling (TUNEL) technique in 70 formalin-fixed and paraffin-embedded RCC specimens.	Formaldehyde	167-175	DNA nucleotidylexotransferase	Homo sapiens	98-101
9510313-3	1998	METHODS: p53 and p21/WAF1 expressions in formalin fixed, paraffin-embedded, preradiation biopsy samples from 49 patients with primary rectal carcinoma were analyzed immunohistochemically.	Formaldehyde	41-49	tumor protein p53	Homo sapiens	9-12
9510313-3	1998	METHODS: p53 and p21/WAF1 expressions in formalin fixed, paraffin-embedded, preradiation biopsy samples from 49 patients with primary rectal carcinoma were analyzed immunohistochemically.	Formaldehyde	41-49	cyclin dependent kinase inhibitor 1A	Homo sapiens	17-20
9510313-3	1998	METHODS: p53 and p21/WAF1 expressions in formalin fixed, paraffin-embedded, preradiation biopsy samples from 49 patients with primary rectal carcinoma were analyzed immunohistochemically.	Formaldehyde	41-49	cyclin dependent kinase inhibitor 1A	Homo sapiens	21-25
9728289-6	1998	To date, the ICRF in situ Hybridisation Service has hybridised over 30,000 sections of principally formalin-fixed, paraffin-embedded tissues, with a high success rate.	Formaldehyde	99-107	regenerating family member 1 alpha	Homo sapiens	13-17
9615190-7	1998	In conclusion, paraffin embedded and formalin fixed PC needle biopsies exhibit a higher diagnostic PCNA/Cyclin than Ki-67/MIB1 index for cases presenting differentiated features, whereas p120 nucleolar protein detection seems to be a suitable marker of poorer outcome of PC.	Formaldehyde	37-45	proliferating cell nuclear antigen	Homo sapiens	104-110
9615190-7	1998	In conclusion, paraffin embedded and formalin fixed PC needle biopsies exhibit a higher diagnostic PCNA/Cyclin than Ki-67/MIB1 index for cases presenting differentiated features, whereas p120 nucleolar protein detection seems to be a suitable marker of poorer outcome of PC.	Formaldehyde	37-45	MIB E3 ubiquitin protein ligase 1	Homo sapiens	122-126
9498109-2	1998	The results showed that relatively lower fluorescence intensity was observed depending on the monoclonal antibodies (mAbs) used for staining; Leu-3a exhibited four-fold lower intensity than Nu-Th/i, and that formaldehyde fixation dramatically reduced fluorescence intensity of macaque CD4+ cells stained with Leu-3a but not of human cells.	Formaldehyde	208-220	CD4 molecule	Homo sapiens	285-288
9773296-6	1998	The technique of microwave antigen retrieval gave crisp, clear immunohistochemical staining for p53 in tissues fixed in neutral buffered formalin or Bouin solution.	Formaldehyde	137-145	tumor protein p53	Homo sapiens	96-99
9475088-4	1998	Linkage to PKD1 was obtained by the analysis of DNA from relatives in three generations and from paraffin blocks and formalin fixed fetal tissues.	Formaldehyde	117-125	polycystin 1, transient receptor potential channel interacting	Homo sapiens	11-15
9522210-2	1998	METHODS AND RESULTS: CD44H and variants (V4/V5, V6) expression was detected by immunohistochemistry in formalin-fixed, paraffin wax tissue samples of Barrett"s mucosa (50) and Barrett"s adenocarcinoma (73) obtained from surgical resections from 73 patients.	Formaldehyde	103-111	CD44 molecule (Indian blood group)	Homo sapiens	21-25
9475192-3	1998	In this report, the utility of immunostaining for inhibin alpha, epithelial membrane antigen, MIC2 gene protein product, and keratin in the differential diagnosis of sex cord-stromal tumors was assessed in formalin-fixed, paraffin-embedded sections.	Formaldehyde	206-214	CD99 molecule (Xg blood group)	Homo sapiens	94-98
10022345-2	1998	Formalin injection resulted in a significant increase in the number of neurons expressing PPE mRNA in the superficial (laminae I-II) and deep (lamina V) layers of the ipsilateral Vc and the first cervical cord (C1).	Formaldehyde	0-8	proenkephalin	Homo sapiens	90-93
10022345-3	1998	The expression of PPE mRNA increased 2 h and 4 h after formalin injection in the neurons of deep layer and superficial layers of the Vc, respectively.	Formaldehyde	55-63	proenkephalin	Homo sapiens	18-21
10022345-4	1998	An increased expression of PPE gene could still be observed 48 h after formalin injection.	Formaldehyde	71-79	proenkephalin	Homo sapiens	27-30
9839528-1	1998	Semicarbazide-sensitive amine oxidase (SSAO)-mediated deamination of methylamine and aminoacetone in vitro produces carbonyl compounds, such as formaldehyde and methylglyoxal, which have been proposed to be cytotoxic and may be responsible for some pathological conditions.	Formaldehyde	144-156	amine oxidase, copper containing 3	Rattus norvegicus	0-37
9435201-2	1998	administered mu and delta opioid receptor agonists on the flinching behavior and the expression of Fos-like immunoreactivity (Fos-LI) in the spinal cord elicited by s.c. injection of 5% formalin in one hindpaw of the rat.	Formaldehyde	186-194	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	99-102
9435201-2	1998	administered mu and delta opioid receptor agonists on the flinching behavior and the expression of Fos-like immunoreactivity (Fos-LI) in the spinal cord elicited by s.c. injection of 5% formalin in one hindpaw of the rat.	Formaldehyde	186-194	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	126-129
9466735-2	1998	In the present study, immunoglobulin heavy chain (IgH) and T-cell receptor (TCR) gene rearrangements were examined by the polymerase chain reaction (PCR) in formalin-fixed and paraffin-embedded specimens obtained from 18 patients; the advantages of this method were evaluated.	Formaldehyde	157-165	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	76-79
9747902-0	1998	Naltrexone, but not atropine or yohimbine, antagonizes suppression of formalin-induced spinal sensitization by intrathecal nociceptin.	Formaldehyde	70-78	prepronociceptin	Homo sapiens	123-133
9747902-2	1998	The results demonstrated that spinal nociceptin suppressed the formalin-induced spinal sensitization in a dose-dependent manner (1, 5 and 10 nmol).	Formaldehyde	63-71	prepronociceptin	Homo sapiens	37-47
9747902-5	1998	Our results show that spinal nociceptin elicits dose-dependent, naltrexone-reversible suppression of spinal sensitization evoked by injection of formalin.	Formaldehyde	145-153	prepronociceptin	Homo sapiens	29-39
9839528-1	1998	Semicarbazide-sensitive amine oxidase (SSAO)-mediated deamination of methylamine and aminoacetone in vitro produces carbonyl compounds, such as formaldehyde and methylglyoxal, which have been proposed to be cytotoxic and may be responsible for some pathological conditions.	Formaldehyde	144-156	amine oxidase, copper containing 3	Rattus norvegicus	39-43
9556419-3	1998	Although there have been multiple studies confirming the association between this erythrocytosis and the production of EPO by tumor cells, immunohistochemical detection of EPO in formalin-fixed, paraffin-embedded tissue was not described.	Formaldehyde	179-187	erythropoietin	Homo sapiens	172-175
9556426-1	1998	We report the development of a reverse-transcriptase polymerase chain reaction assay that detects (in paraffin-embedded, formalin-fixed tissue) the SYT-SSXchimeric RNA transcript resulting from the t(X;18) of synovial sarcoma.	Formaldehyde	121-129	synaptotagmin 1	Homo sapiens	148-151
9601011-4	1998	We have mapped the distribution of Polycomb and other PcG members at various target genes by using an improved formaldehyde cross-linking and chromatin immunoprecipitation technique.	Formaldehyde	111-123	Polycomb	Drosophila melanogaster	35-43
9921916-7	1998	Cytoplasmic CD13 expression was detectable in AML blasts after their buffered-formaldehyde-acetone fixation/permeabilization.	Formaldehyde	78-90	alanyl aminopeptidase, membrane	Homo sapiens	12-16
9680256-0	1998	Kainate GluR5 receptor subtype mediates the nociceptive response to formalin in the rat.	Formaldehyde	68-76	glutamate ionotropic receptor kainate type subunit 1	Rattus norvegicus	8-13
9601011-4	1998	We have mapped the distribution of Polycomb and other PcG members at various target genes by using an improved formaldehyde cross-linking and chromatin immunoprecipitation technique.	Formaldehyde	111-123	Polycomb	Drosophila melanogaster	54-57
9587934-2	1998	In this study a monospecific anti-human bcl-2 antibody that is reactive in formalin-fixed tissues was used with an avidin-biotin complex immunoperoxidase method to evaluate 41 cases of lymphoproliferative disorders of the salivary gland.	Formaldehyde	75-83	BCL2 apoptosis regulator	Homo sapiens	40-45
15678854-6	1998	Immunohistochemical determination of p53 protein was performed on tissular samples formalin fixed and paraffin embedded, using mouse monoclonal antibody DAKO--p53 DO 7 p53 human antiprotein.	Formaldehyde	83-91	tumor protein p53	Homo sapiens	37-40
16793695-3	1998	The abnormality is likely due to a severe defect of the platelet ADP receptor that is coupled to adenylate cyclase, as suggested by the following findings: 1) ADP does not normally lower cAMP levels of PGE1-treated platelets; 2) platelet shape change induced by ADP is normal; 3) the binding of [radiolabelled]ADP to formalin-fixed platelets or of the ADP analogue [radiolabelled]2-MeS-ADP to fresh platelets is severely defective.	Formaldehyde	317-325	purinergic receptor P2Y12	Homo sapiens	56-77
16793697-9	1998	Fixation of platelets by formaldehyde caused artificial binding of annexin V, FVa and FXa as well, irrespective of the platelet activation status.	Formaldehyde	25-37	annexin A5	Homo sapiens	67-76
16793697-9	1998	Fixation of platelets by formaldehyde caused artificial binding of annexin V, FVa and FXa as well, irrespective of the platelet activation status.	Formaldehyde	25-37	coagulation factor X	Homo sapiens	86-89
9740313-3	1998	Under the influence of SSAO, methylamine is deaminated to formaldehyde which is known to react with various macromolecules.	Formaldehyde	58-70	amine oxidase, copper containing 3	Mus musculus	23-27
15678851-4	1998	In this study we analyzed the expression of p53 protein in a variety of salivary gland malignant tumors fixed in formalin and included in paraffin, using the method of immunohistochemical coloring with the anti-p53 DO-7 antibody.	Formaldehyde	113-121	tumor protein p53	Homo sapiens	44-47
9398748-3	1997	To this end, expression of StAR was detected in formalin-fixed, paraffin-embedded specimens using a polyclonal antiserum raised against recombinant human StAR.	Formaldehyde	48-56	steroidogenic acute regulatory protein	Homo sapiens	27-31
9396739-6	1997	Juxtacrine induction by formalin-fixed growth was suppressed to control levels by an inhibitor of HB-EGF and was partially decreased by anti-CD9 antibodies.	Formaldehyde	24-32	heparin binding EGF like growth factor	Homo sapiens	98-104
9396739-6	1997	Juxtacrine induction by formalin-fixed growth was suppressed to control levels by an inhibitor of HB-EGF and was partially decreased by anti-CD9 antibodies.	Formaldehyde	24-32	CD9 molecule	Homo sapiens	141-144
9403705-0	1997	MAGE-3 immunoreactivity in formalin-fixed, paraffin-embedded primary and metastatic melanoma: frequency and distribution.	Formaldehyde	27-35	MAGE family member A3	Homo sapiens	0-6
9389770-8	1997	Using this optimized ImmunoMax method, we were able to detect CD2, CD3, CD4, and CD5 with conventional monoclonal antibodies in formalin-fixed, paraffin-embedded tissue specimens of various lymphoid tissues.	Formaldehyde	128-136	CD2 molecule	Homo sapiens	62-65
9389770-8	1997	Using this optimized ImmunoMax method, we were able to detect CD2, CD3, CD4, and CD5 with conventional monoclonal antibodies in formalin-fixed, paraffin-embedded tissue specimens of various lymphoid tissues.	Formaldehyde	128-136	CD4 molecule	Homo sapiens	72-75
9389770-8	1997	Using this optimized ImmunoMax method, we were able to detect CD2, CD3, CD4, and CD5 with conventional monoclonal antibodies in formalin-fixed, paraffin-embedded tissue specimens of various lymphoid tissues.	Formaldehyde	128-136	CD5 molecule	Homo sapiens	81-84
9503389-10	1997	administration of sendide was found to produce the antinociceptive effect through the blockage of NK-1 receptors in the mouse formalin and capsaicin tests.	Formaldehyde	126-134	tachykinin 1	Mus musculus	98-102
9330358-0	1997	Sex-dependent effects of formalin and restraint on c-Fos expression in the septum and hippocampus of the rat.	Formaldehyde	25-33	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	51-56
9330358-5	1997	In both male and female rats, unilateral injection of formalin induced bilateral c-Fos expression in the hippocampus, but the number of labeled neurons was two-fold higher in females than in males.	Formaldehyde	54-62	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	81-86
9458109-7	1997	In immunohistochemical reactions affinity-purified anti-LMP2 and anti-LMP7 antibodies stained cells in both frozen and formalin-fixed tissue sections of normal skin.	Formaldehyde	119-127	proteasome 20S subunit beta 9	Homo sapiens	56-60
9463925-3	1997	The model predicts that the addition of MTBE to RFG or oxyfuel will decrease acetaldehyde, benzene, 1,3-butadiene and POM, but increase formaldehyde tailpipe emissions.	Formaldehyde	136-148	nuclear receptor coactivator 4	Homo sapiens	48-51
9469524-0	1997	Formalin-induced c-fos expression in the spinal cord of fetal rats.	Formaldehyde	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	17-22
9469524-1	1997	The maturational status of Adelta and C-fibers in the fetal rat spinal cord was examined using formalin-induced c-fos expression as a marker for neuronal activities.	Formaldehyde	95-103	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	112-117
9469524-5	1997	The anatomical data paralleled that of behavior; FD 19 animals expressed a small number of Fos labeled nuclei following the formalin injection that was not statistically different from control animals.	Formaldehyde	124-132	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	91-94
9469524-6	1997	The formalin-induced increase in Fos staining was first observed at FD 20 with a large increase in the number of Fos labeled cell occurring between FD 20 and 21.	Formaldehyde	4-12	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	33-36
9469524-6	1997	The formalin-induced increase in Fos staining was first observed at FD 20 with a large increase in the number of Fos labeled cell occurring between FD 20 and 21.	Formaldehyde	4-12	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	113-116
9469524-9	1997	Formalin treated fetuses showed constitutive level of staining in addition to the increase in the c-fos expression caused by formalin.	Formaldehyde	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	98-103
9469524-9	1997	Formalin treated fetuses showed constitutive level of staining in addition to the increase in the c-fos expression caused by formalin.	Formaldehyde	125-133	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	98-103
9458109-7	1997	In immunohistochemical reactions affinity-purified anti-LMP2 and anti-LMP7 antibodies stained cells in both frozen and formalin-fixed tissue sections of normal skin.	Formaldehyde	119-127	proteasome 20S subunit beta 8	Homo sapiens	70-74
9300417-0	1997	Analgesic effect of intrathecally administered nociceptin, an opioid receptor-like1 receptor agonist, in the rat formalin test.	Formaldehyde	113-121	prepronociceptin	Rattus norvegicus	47-57
9383041-3	1997	Using immunocytochemical and immunoblotting techniques in formalin fixed tissue, we have shown that Glut 5 is exclusively expressed in microglial cells of the human and rat brain.	Formaldehyde	58-66	solute carrier family 2 member 5	Homo sapiens	100-106
9383041-4	1997	Our data demonstrate that unlike other microglial markers, Glut 5 can be used as a microglial marker in formalin fixed tissue.	Formaldehyde	104-112	solute carrier family 2 member 5	Homo sapiens	59-65
9438369-1	1997	In a case of insulin suicide in a nondiabetic woman, insulin was detected in routinely formalin fixed and paraffin embedded subcutaneous injection marks, in spite of a post-morterm interval of 24 days.	Formaldehyde	87-95	insulin	Homo sapiens	13-20
9438369-1	1997	In a case of insulin suicide in a nondiabetic woman, insulin was detected in routinely formalin fixed and paraffin embedded subcutaneous injection marks, in spite of a post-morterm interval of 24 days.	Formaldehyde	87-95	insulin	Homo sapiens	53-60
9363904-5	1997	IL-4 and IL-6 production in A23187-stimulated BMMC was significantly increased at 0.5 and 1 microg/ml formaldehyde but decreased at 5 microg/ml formaldehyde.	Formaldehyde	102-114	interleukin 4	Mus musculus	0-4
9363904-5	1997	IL-4 and IL-6 production in A23187-stimulated BMMC was significantly increased at 0.5 and 1 microg/ml formaldehyde but decreased at 5 microg/ml formaldehyde.	Formaldehyde	102-114	interleukin 6	Mus musculus	9-13
9363904-5	1997	IL-4 and IL-6 production in A23187-stimulated BMMC was significantly increased at 0.5 and 1 microg/ml formaldehyde but decreased at 5 microg/ml formaldehyde.	Formaldehyde	144-156	interleukin 4	Mus musculus	0-4
9363904-5	1997	IL-4 and IL-6 production in A23187-stimulated BMMC was significantly increased at 0.5 and 1 microg/ml formaldehyde but decreased at 5 microg/ml formaldehyde.	Formaldehyde	144-156	interleukin 6	Mus musculus	9-13
9363904-6	1997	After pretreatment with low DEP or formaldehyde alone for 24h, IL-4 production of BMMC stimulated with A23187 was lower in BMMC treated with low DEP or formaldehyde than in controls.	Formaldehyde	35-47	interleukin 4	Mus musculus	63-67
9363904-6	1997	After pretreatment with low DEP or formaldehyde alone for 24h, IL-4 production of BMMC stimulated with A23187 was lower in BMMC treated with low DEP or formaldehyde than in controls.	Formaldehyde	152-164	interleukin 4	Mus musculus	63-67
9363904-7	1997	Antigen-induced IL-4 production significantly increased in BMMC treated with 0.4 or 0.8 microg/ml DEP or 0.5 microg/ml formaldehyde, but antigen-induced IL-6 production in BMMC did not increase at low DEP or formaldehyde.	Formaldehyde	119-131	interleukin 4	Mus musculus	16-20
9363904-7	1997	Antigen-induced IL-4 production significantly increased in BMMC treated with 0.4 or 0.8 microg/ml DEP or 0.5 microg/ml formaldehyde, but antigen-induced IL-6 production in BMMC did not increase at low DEP or formaldehyde.	Formaldehyde	208-220	interleukin 4	Mus musculus	16-20
9415061-6	1997	Formalin-fixed sections, exposed to the monoclonal antibody and stained by an immunogold method, revealed prolactin receptor-immunoreactivity in the dermal papilla, germinal matrix, outer root sheath, lower regions of the inner root sheath and connective tissue sheath of wool follicles.	Formaldehyde	0-8	prolactin receptor	Homo sapiens	106-124
9389798-0	1997	Immunohistochemical detection of adhesion molecules intercellular adhesion molecule-1 and E-selectin in formalin-fixed, paraffin-embedded mouse tissues.	Formaldehyde	104-112	selectin, endothelial cell	Mus musculus	90-100
9352815-2	1997	The specificity of the monoclonal antibody, MIB-1, against the Ki-67 antigen has been established by immunostaining of formalin-fixed paraffin-embedded tissue in a microwave oven.	Formaldehyde	119-127	MIB E3 ubiquitin protein ligase 1	Homo sapiens	44-49
9463579-6	1997	A chimeric transcript of the EWS/FLI-1 fusion gene detected by a nested reverse transcriptase-polymerase chain reaction using formalin-fixed paraffin-embedded tissue justified the diagnosis of pPNET.	Formaldehyde	126-134	EWS RNA binding protein 1	Homo sapiens	29-32
9396137-3	1997	A polyclonal antibody with specificity for AHSV, plus the nonstructural protein NS2, was used in a sensitive avidin-biotin-peroxidase-complex (ABC) method performed on formalin-fixed, paraffin-embedded tissue sections.	Formaldehyde	168-176	hypothetical protein	African horse sickness virus	80-83
9463579-6	1997	A chimeric transcript of the EWS/FLI-1 fusion gene detected by a nested reverse transcriptase-polymerase chain reaction using formalin-fixed paraffin-embedded tissue justified the diagnosis of pPNET.	Formaldehyde	126-134	Fli-1 proto-oncogene, ETS transcription factor	Homo sapiens	33-38
9503571-7	1997	Since SSAO can also metabolize the biogenic aliphatic amine methylamine to formaldehyde (FA), effects of this aldehyde upon HUVEC were also studied.	Formaldehyde	75-87	amine oxidase copper containing 2	Homo sapiens	6-10
9389590-0	1997	Orphanin FQ potentiates formalin-induced pain behavior and antagonizes morphine analgesia in rats.	Formaldehyde	24-32	prepronociceptin	Rattus norvegicus	0-11
16728190-3	1997	When fresh bovine spermatozoa that had been fixed with 4% formaldehyde, smeared on glass slides and then air-dried were stained by FITC-ConA, weak fluorescence was observed on the acrosomal region, although almost all the spermatozoa appeared to be acrosome-intact.	Formaldehyde	58-70	CONA	Bos taurus	136-140
16728193-1	1997	Monoclonal antibodies to human estrogen receptor were used with an indirect immunohistochemical technique to localize in formalin-fixed, paraffin-embedded sections of the genital tract of the bitch.	Formaldehyde	121-129	estrogen receptor 1	Canis lupus familiaris	31-48
9331175-2	1997	One hour after a formalin injection into the lip, many FOS-immunoreactive cells were seen in the parabrachial nucleus, preferentially on the side ipsilateral to the injection site.	Formaldehyde	17-25	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	55-58
9331175-4	1997	In contrast, a formalin injection into the hindpaw resulted in dense FOS-labeling in the superior, dorsal, and central lateral subnuclei, with sparse to moderate labeling in the Kolliker-Fuse nucleus, and sparse labeling in the external lateral and external medial subnuclei, as described previously (Hermanson and Blomqvist, J. Comp.	Formaldehyde	15-23	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	69-72
9389590-9	1997	The present results suggest that OFQ enhances the pain behavior of rat and antagonizes morphine analgesia in formalin test.	Formaldehyde	109-117	prepronociceptin	Rattus norvegicus	33-36
9368590-0	1997	Immunohistochemical detection of p53 in archival formalin-fixed tissues of lip and intraoral squamous cell carcinomas from Norway.	Formaldehyde	49-57	tumor protein p53	Homo sapiens	33-36
9331296-13	1997	In formalin-fixed tissue, tumor cells marked with antibodies to CD43, but not with other T- or B-lineage-related antibodies.	Formaldehyde	3-11	sialophorin	Homo sapiens	64-68
9368590-1	1997	We investigated the expression of p53 in 82 formalin-fixed, paraffin-embedded archival tissue specimens of lip and intraoral squamous cell carcinomas (SCCs) from the period 1930-1995, by immunohistochemistry using three monoclonal antibodies (MAbs DO-7, DO-1 and 1801).	Formaldehyde	44-52	tumor protein p53	Homo sapiens	34-37
9394224-2	1997	administration of monoamine antagonists on formalin-induced neuronal c-Fos expression in two sides of the lumbar dorsal horn were observed in rats with unilateral transection of the dorsolateral funiculus at T11-12 level.	Formaldehyde	43-51	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	69-74
9343323-16	1997	Moreover, we present data that suggests that evaluating for TdT in formalin-fixed paraffin-embedded tissue is a more sensitive test than using either 12E7, bcl-2 or CD34 alone.	Formaldehyde	67-75	DNA nucleotidylexotransferase	Homo sapiens	60-63
9421067-2	1997	A topographic genotyping approach was used to search for point mutations in K-ras-2 (exon 1 and 2) and p53 (exons 5 to 8) in archival formalin-fixed tissue blocks.	Formaldehyde	134-142	KRAS proto-oncogene, GTPase	Homo sapiens	76-83
9394224-4	1997	normal saline (control) and then an equal volume of formalin was injected into the two hindpaws, the number of Fos-like immunoreactive neurons were 44% lower on the side of lumbar dorsal horn with intact dorsolateral funiculus (57 +/- 3.1 vs. 103 +/- 3.8).	Formaldehyde	52-60	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	111-114
9268242-0	1997	Detection of three transthyretin gene mutations in familial amyloidotic polyneuropathy by analysis of DNA extracted from formalin-fixed and paraffin-embedded tissues.	Formaldehyde	121-129	transthyretin	Homo sapiens	19-32
9369310-3	1997	The distributions of Fos-positive neurons were restricted rostro-caudally following formalin injection and tissue injury compared to transection of the infraorbital nerve.	Formaldehyde	84-92	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	21-24
9390038-3	1997	This study describes the generation and characterisation of two novel murine monoclonal antibodies recognizing ER and PgR, designated NCL-ER-6F11 and NCL-PGR respectively, which are effective in heat-treated formalin-fixed, paraffin-embedded tissue.	Formaldehyde	208-216	progesterone receptor	Homo sapiens	118-121
9390038-3	1997	This study describes the generation and characterisation of two novel murine monoclonal antibodies recognizing ER and PgR, designated NCL-ER-6F11 and NCL-PGR respectively, which are effective in heat-treated formalin-fixed, paraffin-embedded tissue.	Formaldehyde	208-216	progesterone receptor	Homo sapiens	154-157
9349575-10	1997	Immunostaining of the corresponding formalin-fixed paraffin-embedded tissue sections detected MUC1 mucin protein at the apical domain of follicular cells.	Formaldehyde	36-44	mucin 1, cell surface associated	Homo sapiens	94-98
9349575-10	1997	Immunostaining of the corresponding formalin-fixed paraffin-embedded tissue sections detected MUC1 mucin protein at the apical domain of follicular cells.	Formaldehyde	36-44	LOC100508689	Homo sapiens	99-104
9268242-1	1997	We identified three different missense mutations of the transthyretin (TTR) gene in three Japanese patients with familial amyloidotic polyneuropathy by analysis of their DNAs extracted from formalin-fixed and paraffin-embedded tissues.	Formaldehyde	190-198	transthyretin	Homo sapiens	56-69
9268242-1	1997	We identified three different missense mutations of the transthyretin (TTR) gene in three Japanese patients with familial amyloidotic polyneuropathy by analysis of their DNAs extracted from formalin-fixed and paraffin-embedded tissues.	Formaldehyde	190-198	transthyretin	Homo sapiens	71-74
9413739-3	1997	In the present study, a reliable immunostaining method was used to detect p120 on formalin-fixed, paraffin wax-embedded tissue, testing it on 148 samples from different neoplastic and non-neoplastic tissues from different organs (breast, colon, lung, prostate, bladder, lymph nodes, skin, tongue and liver).	Formaldehyde	82-90	NOP2 nucleolar protein	Homo sapiens	74-78
9308731-5	1997	In this investigation, we assessed the immunoreactive patterns of HGF and MET in benign and malignant peripheral nerve sheath tumors (PNST) using archival formalin-fixed tissue.	Formaldehyde	155-163	hepatocyte growth factor	Homo sapiens	66-69
9413739-6	1997	Our results show that the nucleolar protein p120 can be detected by routine immunohistochemistry in formalin-fixed, paraffin-embedded tissue and is expressed in all nucleated cells under any biological condition.	Formaldehyde	100-108	NOP2 nucleolar protein	Homo sapiens	44-48
21590166-5	1997	carcinomas of female breast with and without lymph node metastasis for p53 protein overexpression by immunohistochemistry on formalin-fixed, paraffin-embedded tissue sections to ascertain if p53 positive tumors have greater metastatic potential than p53 negative tumors.	Formaldehyde	125-133	tumor protein p53	Homo sapiens	71-74
9300764-4	1997	By using the fluorescent lipophilic dye DiI in formalin-fixed human hippocampal tissue, we demonstrated that this is a continuous fiber pathway between the deep hilar region and CA2.	Formaldehyde	47-55	carbonic anhydrase 2	Homo sapiens	178-181
9334842-4	1997	Formalin-fixed, paraffin-embedded sections were stained with haematoxylin-eosin, PAS-diastase and a monoclonal antibody (BRST-2) anti-GCDFP-15, which is a specific apocrine marker.	Formaldehyde	0-8	prolactin induced protein	Homo sapiens	134-142
9323836-7	1997	Results indicate that MyoD1 immunostaining, in contrast to desmin, maintains its sensitivity following prolonged formalin fixation and may be of value to distinguish RMS from other soft tissue sarcomas in the rat.	Formaldehyde	113-121	myogenic differentiation 1	Rattus norvegicus	22-27
9288745-3	1997	Using formaldehyde cross-linking, we show that Cdc6p and Mcm7p associate specifically with replication origins during G1 but not during G2 in S. cerevisiae.	Formaldehyde	6-18	AAA family ATPase CDC6	Saccharomyces cerevisiae S288C	47-52
9288745-3	1997	Using formaldehyde cross-linking, we show that Cdc6p and Mcm7p associate specifically with replication origins during G1 but not during G2 in S. cerevisiae.	Formaldehyde	6-18	mini-chromosome maintenance complex protein 7	Saccharomyces cerevisiae S288C	57-62
9359591-0	1997	Formalin-evoked Fos expression in spinal cord is enhanced in morphine-tolerant rats.	Formaldehyde	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	16-19
9359591-4	1997	Although there was no significant difference in flinching behavior between the morphine-tolerant and control groups, we recorded significantly increased total Fos-like immunoreactivity at the L4/5 and L2 segments both ipsilateral and contralateral to the site of formalin injection in the morphine-tolerant rats compared to the control rats.	Formaldehyde	263-271	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	159-162
9276523-10	1997	Indirect immunofluorescence (IIF) analysis confirmed that AGM 2.29 and AGM 10.14 reacted with human granulocytes, showing a cytoplasmic pattern on formalin-acetone-fixed neutrophils and a perinuclear one on ethanol-fixed cells.	Formaldehyde	147-155	immunoglobulin lambda like polypeptide 1	Homo sapiens	58-63
9270000-6	1997	The possibility of a simple assay, such as the immunohistochemical analysis of p27 expression on routinely formalin-fixed, paraffin-embedded specimens, has considerable value for the prognosis of patients who undergo surgical resection.	Formaldehyde	107-115	interferon alpha inducible protein 27	Homo sapiens	79-82
9284204-3	1997	The immunohistochemical analysis of chromogranin A and neuron-specific enolase in formalin-fixed, paraffin wax embedded prostatic tissue chips was related to other prognostic variables and patient survival.	Formaldehyde	82-90	chromogranin A	Homo sapiens	36-50
9284204-3	1997	The immunohistochemical analysis of chromogranin A and neuron-specific enolase in formalin-fixed, paraffin wax embedded prostatic tissue chips was related to other prognostic variables and patient survival.	Formaldehyde	82-90	enolase 2	Homo sapiens	55-78
9285117-1	1997	GGT 129, a polyclonal antibody directed against gamma-glutamyl transpeptidase (GGT), was used to study GGT expression in formalin-fixed paraffin-embedded tissues from normal breast, 24 benign lesions, 27 in situ carcinomas or atypical hyperplasias, and 79 infiltrating mammary carcinomas.	Formaldehyde	121-129	inactive glutathione hydrolase 2	Homo sapiens	0-3
9286277-3	1997	METHODS: Expression of HLA-A and -B antigens was determined on 30 formalin-fixed and paraffin-embedded sections of uveal melanoma by immunohistochemistry with locus-specific monoclonal antibodies and scored semiquantitatively.	Formaldehyde	66-74	major histocompatibility complex, class I, A	Homo sapiens	23-35
9264569-4	1997	Formalin-fixed paraffin-embedded sections from 234 patients with endometrial cancer were immunostained with a mouse monoclonal IgG to nm23/NDPK-A protein.	Formaldehyde	0-8	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	134-138
9272437-3	1997	The presence of Pgp expression in formalin-fixed and wax-processed tissue sections can be assessed using the monoclonal antibody, JSB-1.	Formaldehyde	34-42	phosphoglycolate phosphatase	Homo sapiens	16-19
9274823-1	1997	Human immunodeficiency virus type 1 (HIV-1) infection of the brain has been demonstrated in formalin fixed, paraffin embedded post-mortem brain tissue (PM) by chromogenic immunohistochemistry for the HIV p24 antigen.	Formaldehyde	92-100	transmembrane p24 trafficking protein 2	Homo sapiens	204-207
9306962-6	1997	The expression of TP was therefore examined in 75 formalin-fixed, paraffin-embedded specimens of DCIS by immunohistochemistry, using the monoclonal antibody PGF44c to detect TP.	Formaldehyde	50-58	thymidine phosphorylase	Homo sapiens	18-20
9308027-2	1997	injection of NK1 receptor antagonists GR 82334 and FK 888 (1-50 pmol/paw), in association with formalin, produced graded inhibition of the early but not the late phase of the formalin test.	Formaldehyde	95-103	tachykinin receptor 1	Mus musculus	13-25
9267826-10	1997	HER-2/neu oncogene amplification can be assessed using automated FISH on formalin-fixed, paraffin-embedded tissue.	Formaldehyde	73-81	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-5
9267826-10	1997	HER-2/neu oncogene amplification can be assessed using automated FISH on formalin-fixed, paraffin-embedded tissue.	Formaldehyde	73-81	erb-b2 receptor tyrosine kinase 2	Homo sapiens	6-9
9267824-10	1997	We conclude that staining formalin-fixed, paraffin-embedded, high-grade lymphomas with anti-cyclin D-1 antibody is useful in confirming the diagnosis of MCL-BV, whereas positive reactions with CD99, CD34, and particularly TdT are more characteristic of LBL.	Formaldehyde	26-34	cyclin D1	Homo sapiens	92-102
9308027-2	1997	injection of NK1 receptor antagonists GR 82334 and FK 888 (1-50 pmol/paw), in association with formalin, produced graded inhibition of the early but not the late phase of the formalin test.	Formaldehyde	175-183	tachykinin receptor 1	Mus musculus	13-25
9308027-3	1997	The NK2, SR 48968 and NK3 SR 142801 receptor antagonists (1-50 pmol/paw) were effective in inhibiting both phases of the formalin model.	Formaldehyde	121-129	hepatocyte growth factor	Mus musculus	4-7
9308019-1	1997	The presence of Fos-labeled neurons at ultrastructural level was confirmed in the spinal superficial laminae following an injection of formalin into rat hindpaw in the present study.	Formaldehyde	135-143	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	16-19
9260198-5	1997	mc-GAD-Abs recognizing conformational epitope regions (p2) revealed a marked reduced immunoreactivity on pancreatic sections fixed for 18 h with 4% formaldehyde, while mc-GAD-Abs reactive with linear epitopes (p1, p3) were detectable with strong binding.	Formaldehyde	148-160	glutamate decarboxylase 1	Homo sapiens	3-6
9308027-7	1997	injection of the NK3 receptor antagonist SR 142801 against both phases of the formalin test, but not that of NK1 and NK2 receptor antagonists, was significantly reversed by intraperitoneal (i.p.)	Formaldehyde	78-86	tachykinin receptor 3	Mus musculus	17-29
9260198-9	1997	In conclusion, the fixation of human pancreatic sections with formaldehyde for 18 h allows the differentiation of GAD-AAbs recognizing linear and conformational epitope regions.	Formaldehyde	62-74	glutamate decarboxylase 1	Homo sapiens	114-117
9308027-10	1997	injection of NK1, NK2 or NK3 receptor antagonists (15-500 pmol/site), all produced significant and dose-dependent inhibition of both phases of the formalin and capsaicin tests.	Formaldehyde	147-155	tachykinin 1	Mus musculus	13-16
9308027-10	1997	injection of NK1, NK2 or NK3 receptor antagonists (15-500 pmol/site), all produced significant and dose-dependent inhibition of both phases of the formalin and capsaicin tests.	Formaldehyde	147-155	hepatocyte growth factor	Mus musculus	18-21
9308027-10	1997	injection of NK1, NK2 or NK3 receptor antagonists (15-500 pmol/site), all produced significant and dose-dependent inhibition of both phases of the formalin and capsaicin tests.	Formaldehyde	147-155	tachykinin receptor 3	Mus musculus	25-37
9308027-20	1997	However, when injected i.c.v., the antinociception caused by NK1, NK2 or NK3 receptor antagonists was largely reversed by naloxone when assessed in the formalin test, suggesting a distinct mechanism of action.	Formaldehyde	152-160	tachykinin 1	Mus musculus	61-64
11536828-3	1997	Since uracil reacts rapidly with formaldehyde and other aldehydes at the C-5 position, it is plausible that pseudouridine could be synthesized in a similar way by the reaction of the C-5 of uracil with the C-1 of ribose.	Formaldehyde	33-45	complement C5	Homo sapiens	73-76
11536828-3	1997	Since uracil reacts rapidly with formaldehyde and other aldehydes at the C-5 position, it is plausible that pseudouridine could be synthesized in a similar way by the reaction of the C-5 of uracil with the C-1 of ribose.	Formaldehyde	33-45	complement C5	Homo sapiens	183-186
11536828-3	1997	Since uracil reacts rapidly with formaldehyde and other aldehydes at the C-5 position, it is plausible that pseudouridine could be synthesized in a similar way by the reaction of the C-5 of uracil with the C-1 of ribose.	Formaldehyde	33-45	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	206-209
9308027-20	1997	However, when injected i.c.v., the antinociception caused by NK1, NK2 or NK3 receptor antagonists was largely reversed by naloxone when assessed in the formalin test, suggesting a distinct mechanism of action.	Formaldehyde	152-160	tachykinin receptor 3	Mus musculus	73-85
9240173-4	1997	The expression of the MDR-1 gene product was determined immunohistochemically using the JSB-1 antibody in formalin-fixed paraffin-embedded tumour samples from these patients.	Formaldehyde	106-114	ATP binding cassette subfamily B member 1	Homo sapiens	22-27
9214544-5	1997	Vc neurons in which c-fos protein-like immunoreactivity (Fos-LI) was induced by subcutaneous injection of formalin into the lip were considered nociceptive.	Formaldehyde	106-114	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	22-25
9214544-5	1997	Vc neurons in which c-fos protein-like immunoreactivity (Fos-LI) was induced by subcutaneous injection of formalin into the lip were considered nociceptive.	Formaldehyde	106-114	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	57-60
9290637-1	1997	We have previously shown that intact plants and cultured plant cells can metabolize and detoxify formaldehyde through the action of a glutathione-dependent formaldehyde dehydrogenase (FDH), followed by C-1 metabolism of the initial metabolite (formic acid).	Formaldehyde	97-109	alcohol dehydrogenase class-3	Zea mays	156-182
9290637-1	1997	We have previously shown that intact plants and cultured plant cells can metabolize and detoxify formaldehyde through the action of a glutathione-dependent formaldehyde dehydrogenase (FDH), followed by C-1 metabolism of the initial metabolite (formic acid).	Formaldehyde	97-109	alcohol dehydrogenase class-3	Zea mays	184-187
9252683-6	1997	In the present immunocytochemical study, PSA expression was examined employing a biotin-streptavidin based, alkaline phosphatase conjugated antigen detection technique in 16 routine, neutral formalin fixed, paraffin-wax embedded, primary BC tissue sections.	Formaldehyde	191-199	kallikrein related peptidase 3	Homo sapiens	41-44
9253517-4	1997	DESIGN AND METHODS: An Apo-E genotyping method was tested for use on formalin-fixed paraffin-embedded brain tissue, using semi-nested PCR followed by hybridization with biotin-labeled allele-specific oligonucleotides, and chemiluminescent detection.	Formaldehyde	69-77	apolipoprotein E	Homo sapiens	23-28
9349230-2	1997	The present study of the polymerase chain reaction (PCR) as a diagnostic tool in early mycosis fungoides was therefore undertaken, using a rapid PCR method for the detection of gamma- and beta-chain T-cell receptor (TCR) gene rearrangements in routine formalin-fixed, paraffin-embedded histological sections.	Formaldehyde	252-260	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	216-219
9282199-2	1997	Overexpression of cyclin D1 was detected immunohistochemically using DCS6 monoclonal antibody on formalin-fixed, paraffin-embedded tissue sections.	Formaldehyde	97-105	cyclin D1	Homo sapiens	18-27
9211488-6	1997	A simple and nonradio-active PCR/RFLP-based method for detection of K-ras codon 12 mutations in formalin-fixed, paraffin-embedded tissue sections of pancreatic adenocarcinoma is described and compared to the traditional PCR technique.	Formaldehyde	96-104	KRAS proto-oncogene, GTPase	Homo sapiens	68-73
9204999-7	1997	Alternatively, especially for the analysis of small numbers of cells (for example sorted subpopulations of leukemic cells), convenient and sensitive procedures are being developed by using DNA-binding Pgp substrates which remain fixed in the nuclei of the cells upon formaldehyde exposure for quantitative fluorescence laser scanning microscopy with image analysis.	Formaldehyde	267-279	ATP binding cassette subfamily B member 1	Homo sapiens	201-204
9211488-9	1997	This study demonstrates that the sensitivity of the simple two-step EN-PCR/RFLP technique is comparable to that of the more complex methods for detecting K-ras mutations at codon 12 in formalin-fixed, paraffin-embedded tissue sections of pancreatic adenocarcinoma and its sensitivity is superior to that of the single-step technique.	Formaldehyde	185-193	KRAS proto-oncogene, GTPase	Homo sapiens	154-159
9218679-0	1997	Intrathecally administered c-fos antisense oligodeoxynucleotide decreases formalin-induced nociceptive behavior in adult rats.	Formaldehyde	74-82	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	27-32
9218679-1	1997	c-fos antisense strategy was applied as a pharmacological approach to characterize its dose-dependent role and reversibility in the reduction of formalin-induced hyperalgesia.	Formaldehyde	145-153	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-5
9378810-1	1997	AIMS: The generation and characterisation of a monoclonal antibody that specifically recognises the mdr-1 encoded protein, P-glycoprotein (P-170), on routinely processed formalin fixed, paraffin wax embedded tissue sections.	Formaldehyde	170-178	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	100-105
9218803-3	1997	We have mapped, at high resolution, the distribution of Polycomb protein on the bithorax complex of Drosophila tissue culture cells, using an improved formaldehyde cross-linking and immunoprecipitation technique.	Formaldehyde	151-163	Polycomb	Drosophila melanogaster	56-64
9276135-0	1997	Endothelins potentiate formalin-induced nociception and paw edema in mice.	Formaldehyde	23-31	endothelin 1	Mus musculus	0-11
9276135-3	1997	All three peptides potentiated the second phase (10-30 min after injection) of formalin-induced nociception (at 3-30, 1-30, and 10-30 pmol/paw for ET-1, ET-3, and SRTX-c, respectively), whereas only ET-1 (10 or 30 pmol/paw) effectively enhanced edema caused by formalin (30 min after injection).	Formaldehyde	79-87	endothelin 1	Mus musculus	199-203
9276135-6	1997	Thus, ET-1 potentiates formalin-induced nociception and edema in the mouse.	Formaldehyde	23-31	endothelin 1	Mus musculus	6-10
9242590-1	1997	Metabolism of dichloromethane (DCM) to formaldehyde (HCHO) via a glutathione S-transferase (GST) pathway is thought to be required for its carcinogenic effects in B6C3F1 mice.	Formaldehyde	39-51	hematopoietic prostaglandin D synthase	Mus musculus	65-90
9242590-1	1997	Metabolism of dichloromethane (DCM) to formaldehyde (HCHO) via a glutathione S-transferase (GST) pathway is thought to be required for its carcinogenic effects in B6C3F1 mice.	Formaldehyde	39-51	hematopoietic prostaglandin D synthase	Mus musculus	92-95
9378810-1	1997	AIMS: The generation and characterisation of a monoclonal antibody that specifically recognises the mdr-1 encoded protein, P-glycoprotein (P-170), on routinely processed formalin fixed, paraffin wax embedded tissue sections.	Formaldehyde	170-178	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha	Mus musculus	139-144
9223086-1	1997	The aims of this study were to investigate the dose-dependent effects of spinally delivered nociceptin (0.3, 1, 3.3 and 10 nmol) on flinching behaviour in the rat formalin test and whether these effects were influenced by the concomitant systemic administration of naloxone (3 mg/kg, i.p.).	Formaldehyde	163-171	prepronociceptin	Rattus norvegicus	92-102
9180213-0	1997	Protein synthesis inhibitor cycloheximide dose-dependently decreases formalin-induced c-Fos protein and behavioral hyperalgesia in rats.	Formaldehyde	69-77	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	86-91
9180213-1	1997	We had previously demonstrated that c-fos antisense oligodeoxynucleotides dose-dependently suppressed formalin-induced c-Fos protein and behavioral hyperalgesia.	Formaldehyde	102-110	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	36-41
9180213-1	1997	We had previously demonstrated that c-fos antisense oligodeoxynucleotides dose-dependently suppressed formalin-induced c-Fos protein and behavioral hyperalgesia.	Formaldehyde	102-110	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	119-124
9180213-2	1997	To test whether de novo protein synthesis is required for the development of persistent pain after peripheral inflammation, we observed formalin-induced spinal c-Fos protein and nociceptive behaviors following pretreatment with cycloheximide, a protein synthesis inhibitor.	Formaldehyde	136-144	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	160-165
9180213-3	1997	Cycloheximide dose-dependently inhibited formalin-induced spinal c-Fos protein and tonic nociceptive responses.	Formaldehyde	41-49	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	65-70
9139707-7	1997	Immunohistochemical staining of formalin-fixed paraffin-embedded rat heart tissue sections using the anti-CYP2J2 IgG and avidin-biotin-peroxidase detection localized expression of CYP2J3 primarily to atrial and ventricular myocytes.	Formaldehyde	32-40	cytochrome P450, family 2, subfamily j, polypeptide 3	Rattus norvegicus	180-186
9292148-2	1997	This study was undertaken to evaluate four anti-WT1 antibodies and use the most specific one to examine the expression of WT1 in formalin fixed, paraffin wax embedded tissues from human embryos, fetuses, and paediatric renal neoplasms.	Formaldehyde	129-137	WT1 transcription factor	Homo sapiens	122-125
9292148-13	1997	CONCLUSIONS: WT1 is detected readily in formalin fixed material.	Formaldehyde	40-48	WT1 transcription factor	Homo sapiens	13-16
9178652-3	1997	To examine the role of supraspinal and/or spinal endogenous delta1-opioid receptors in inhibiting the formalin-induced nociceptive response in diabetic mice, we assessed the effect of 7-benzylidenenaltrexone, a selective delta1-opioid receptor antagonist, and naltriben, a selective delta2-opioid receptor antagonist, administered either i.c.v.	Formaldehyde	102-110	opioid receptor, delta 1	Mus musculus	60-82
9178652-10	1997	These results suggest that a spinal delta1-opioid receptor-mediated endogenous antinociceptive system may inhibit the formalin-induced second phase of the nociceptive response in diabetic mice.	Formaldehyde	118-126	opioid receptor, delta 1	Mus musculus	36-58
9160807-1	1997	Among methanol and its metabolites, formaldehyde was found to have the strongest inactivating effect on the activity of alpha1-antitrypsin preparation and inhibitor existing in blood serum.	Formaldehyde	36-48	serpin family A member 1	Homo sapiens	120-138
9160807-2	1997	The influence of formaldehyde on the activity of serum alpha1-antitrypsin is lower in comparison with purified inhibitor.	Formaldehyde	17-29	serpin family A member 1	Homo sapiens	55-73
9160807-3	1997	alpha1-Antitrypsin modified by formaldehyde inactivates the trypsin in its action on the BAPA to a smaller degree than on the hemoglobin.	Formaldehyde	31-43	serpin family A member 1	Homo sapiens	0-18
9787241-1	1997	Immunoreactivity of the immediate early gene c-fos was used to investigate changes in the activity of brainstem neurons in response to acute stressors like immobilization, formalin-induced pain, cold exposure, hemorrhage and insulin-induced hypoglycemia.	Formaldehyde	172-180	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	45-50
9216675-3	1997	Formalin-fixed paraffin embedded tissue from 102 cases of breast carcinomas comprising mostly ductal carcinomas (88 cases) was stained by immunohistochemistry for p53, mdm2 and p21/waf1 proteins.	Formaldehyde	0-8	cyclin dependent kinase inhibitor 1A	Homo sapiens	181-185
9216712-4	1997	We examined the expression of PSA employing a biotin-streptavidin based, alkaline phosphatase conjugated antigen detection technique in routine, neutral formalin fixed, paraffin-wax embedded, 3-4 microns thick tissue sections of 30 CMMs and 10 MMMs.	Formaldehyde	153-161	kallikrein related peptidase 3	Homo sapiens	30-33
9131641-3	1997	This product can be further deaminated by semicarbazide-sensitive amine oxidase (SSAO) and converted to toxic formaldehyde, hydrogen peroxide and ammonia.	Formaldehyde	110-122	amine oxidase copper containing 2	Homo sapiens	42-79
9131641-3	1997	This product can be further deaminated by semicarbazide-sensitive amine oxidase (SSAO) and converted to toxic formaldehyde, hydrogen peroxide and ammonia.	Formaldehyde	110-122	amine oxidase copper containing 2	Homo sapiens	81-85
9208332-4	1997	In situ hybridization assays using digoxigenin-labeled riboprobes for the detection of EF-1 alpha mRNA in routinely formalin-fixed, paraffin-embedded tissue sections showed that EF-1 alpha is a suitable positive control in all types of cells.	Formaldehyde	116-124	eukaryotic translation elongation factor 1 alpha 2	Homo sapiens	87-97
9267487-3	1997	A commercial monoclonal antibody directed against the human beta 1 integrin was tested in order to design a method for the detection of this antigen in formalin-fixed, paraffin-embedded human kidney tissue.	Formaldehyde	152-160	integrin subunit beta 1	Homo sapiens	60-75
9098647-3	1997	To apply these molecular markers to commonly available archival material, we used reverse transcriptase-polymerase chain reaction and oligonucleotide hybridization methodology to develop an assay capable of identifying PAX3-FKHR and PAX7-FKHR fusion transcripts in formalin-fixed, paraffin-embedded tissue.	Formaldehyde	265-273	paired box 3	Homo sapiens	219-223
9163536-1	1997	Intraplantar injection of dilute formalin evokes brief (Phase 1) and persistent (Phase 2) increases in primary afferent activity, pain behavior, and cardiovascular responses, and induces spinal cord Fos-like immunoreactivity (Fos-LI).	Formaldehyde	33-41	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	199-202
9163536-1	1997	Intraplantar injection of dilute formalin evokes brief (Phase 1) and persistent (Phase 2) increases in primary afferent activity, pain behavior, and cardiovascular responses, and induces spinal cord Fos-like immunoreactivity (Fos-LI).	Formaldehyde	33-41	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	226-229
9147381-2	1997	Consistent with previously published observations, paw formalin injection evoked a distinct pattern of FOS protein expression in L3-L5 spinal segments.	Formaldehyde	55-63	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	103-106
9147381-5	1997	In contrast, ipsilateral paw formalin injection, if administered 4 h after carrageenan-induced knee inflammation, evoked significantly fewer FOS positive neurons in all laminar and segmental levels analyzed as compared with formalin injected animals but without previous knee joint inflammation.	Formaldehyde	29-37	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	141-144
12114668-5	1997	Immunohistochemical staining for p53 was performed on paraffin sections of formalin-fixed tumor tissue.	Formaldehyde	75-83	tumor protein p53	Homo sapiens	33-36
9138112-1	1997	The expression of c-myc protein was studied in formalin-fixed, paraffin-embedded sections of 16 compound Spitz nevi (SNs), 20 ordinary compound melanocytic nevi (MNs) and 30 malignant melanomas (MMs), using monoclonal antibody 9E10 and an immunoperoxidase technique.	Formaldehyde	47-55	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	18-23
9098575-1	1997	The effects of inhalation anesthetics, nitrous oxide (N2O) and halothane, on the expression of c-Fos protein evoked by formalin injection were studied in the spinal cord in the rat.	Formaldehyde	119-127	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	95-100
9215143-11	1997	CONCLUSION: PCR-SSP HLA class II DRB and DQB1 typing is reliably applicable to DNA extracted from formalin fixed and paraffin wax embedded tissue.	Formaldehyde	98-106	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	41-45
9111386-1	1997	The monoclonal antibody MIB1 recognizing the Ki-67 antigen in formalin-fixed, paraffin-embedded tissue was used to study the proliferative activity in 44 adenoid cystic carcinomas of the salivary glands.	Formaldehyde	62-70	MIB E3 ubiquitin protein ligase 1	Homo sapiens	24-28
9070747-1	1997	In urethane anaesthetized rats subcutaneous formalin injection in the right hind paw, a model of persistent pain, produced (i) a prolonged increase in the period of field rhythmic sinusoidal (or theta) activity, (ii) a depression of dorsal hippocampal field CA1 pyramidal cell synaptic excitability (mean peak depression of population spike amplitude being 50 +/- 6%) observed to the 60th min post injection, and (iii) a persistent decrease in extracellular activity of the majority of CA1 pyramidal cells (15/20 or 75%) with only a small percentage excited (5/20 or 25%).	Formaldehyde	44-52	carbonic anhydrase 1	Rattus norvegicus	258-261
9070747-1	1997	In urethane anaesthetized rats subcutaneous formalin injection in the right hind paw, a model of persistent pain, produced (i) a prolonged increase in the period of field rhythmic sinusoidal (or theta) activity, (ii) a depression of dorsal hippocampal field CA1 pyramidal cell synaptic excitability (mean peak depression of population spike amplitude being 50 +/- 6%) observed to the 60th min post injection, and (iii) a persistent decrease in extracellular activity of the majority of CA1 pyramidal cells (15/20 or 75%) with only a small percentage excited (5/20 or 25%).	Formaldehyde	44-52	carbonic anhydrase 1	Rattus norvegicus	486-489
9070747-7	1997	The formalin injection-induced selective activation of CA1 complex spike cells against a background of widespread pyramidal cell suppression might produce a "signal to noise" contributory to nociceptive processing in limbic structures.	Formaldehyde	4-12	carbonic anhydrase 1	Rattus norvegicus	55-58
9150301-0	1997	Changes in formalin-evoked spinal Fos expression and nociceptive behaviour after oral administration of Bufferin A (aspirin) and L-5409709 (ibuprofen + caffeine + paracetamol).	Formaldehyde	11-19	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	34-37
9150301-1	1997	This study compares the effects of two non-steroidal anti-inflammatory drugs, Bufferin A (BA) and L-5409709 (L-54), on nociceptive behaviour and spinal Fos expression induced by subcutaneous formalin in the rat.	Formaldehyde	191-199	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	152-155
9150301-8	1997	The two drugs had different effects on the number of spinal Fos-like immunoreactive neurones 2 h after the formalin injection.	Formaldehyde	107-115	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	60-63
9098575-2	1997	The expression of c-Fos protein was detected by immunocytochemistry following the injection of formalin (5%, 100 microliters) into the plantar surface of the left hindpaw.	Formaldehyde	95-103	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	18-23
9048644-3	1997	Immunohistochemical staining of formalin-fixed paraffin-embedded rat and human pancreas using the anti-CYP2J2 IgG and avidin-biotin-peroxidase detection revealed that CYP2J2 protein expression was highly localized to cells in the islets of Langerhans, with minimal staining in pancreatic exocrine cells.	Formaldehyde	32-40	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	103-109
27006577-2	1997	METHODS: The point mutations at codon 12 and 61 of c-Ha-ras, at codon 12 and 13 of K-ras, and at codon 12 of N-ras were studied with PCR-RFLP in 88 formalin fixed and paraffin embedded specimens of gastric cancer.	Formaldehyde	148-156	NRAS proto-oncogene, GTPase	Homo sapiens	109-114
9375023-1	1997	The recent availability of the monoclonal antibody MIB-1 (which is able to detect the human nuclear cell proliferation-associated antigen Ki-67 even on formalin-fixed, paraffin-embedded sections, microwave-treated and routinely processed for immunohistochemistry) could open new avenues for validation of the clinical role of tumour cell proliferation on large, consecutive and unselected series of human tumours.	Formaldehyde	152-160	MIB E3 ubiquitin protein ligase 1	Homo sapiens	51-56
9375023-4	1997	The median values of MIB-1 indices following 2, 6 and 24 h of formalin fixation were similar (29.4%, 30.6% and 29.7%, respectively) and consistent with those reported in the literature; squared linear regression coefficients were 0.99.	Formaldehyde	62-70	MIB E3 ubiquitin protein ligase 1	Homo sapiens	21-26
9048644-3	1997	Immunohistochemical staining of formalin-fixed paraffin-embedded rat and human pancreas using the anti-CYP2J2 IgG and avidin-biotin-peroxidase detection revealed that CYP2J2 protein expression was highly localized to cells in the islets of Langerhans, with minimal staining in pancreatic exocrine cells.	Formaldehyde	32-40	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	167-173
9030636-0	1997	Phosphorylation of transcription factor CREB in rat spinal cord after formalin-induced hyperalgesia: relationship to c-fos induction.	Formaldehyde	70-78	cAMP responsive element binding protein 1	Rattus norvegicus	40-44
9138481-0	1997	Immunohistochemical detection of p21WAF1/CIP1 and p53 proteins in formalin-fixed paraffin-embedded tissue sections of squamous cell carcinoma of the skin.	Formaldehyde	66-74	cyclin dependent kinase inhibitor 1A	Homo sapiens	41-45
9138481-0	1997	Immunohistochemical detection of p21WAF1/CIP1 and p53 proteins in formalin-fixed paraffin-embedded tissue sections of squamous cell carcinoma of the skin.	Formaldehyde	66-74	tumor protein p53	Homo sapiens	50-53
9030636-0	1997	Phosphorylation of transcription factor CREB in rat spinal cord after formalin-induced hyperalgesia: relationship to c-fos induction.	Formaldehyde	70-78	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	117-122
9030636-4	1997	After a unilateral injection of formalin into the hindpaw, a strong and bilateral phosphorylation of CREB Ser133 was induced, as assessed by both immunohistochemistry and Western blot.	Formaldehyde	32-40	cAMP responsive element binding protein 1	Rattus norvegicus	101-105
9030636-6	1997	CREB phosphorylation was very rapid and reached peak levels within 10 min of formalin treatment, whereas few pCREB-positive neurons were seen in unstimulated spinal cord.	Formaldehyde	77-85	cAMP responsive element binding protein 1	Rattus norvegicus	0-4
9030636-8	1997	In contrast to CREB phosphorylation, the induction of c-Fos expression reached peak levels 2 hr after formalin treatment and c-Fos induction was mainly ipsilateral.	Formaldehyde	102-110	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	54-59
9030636-9	1997	Both formalin-evoked CREB phosphorylation and c-Fos expression in the spinal cord were suppressed by pretreatment with the NMDA receptor antagonist MK-801 (3.5 mg/kg, i.p.)	Formaldehyde	5-13	cAMP responsive element binding protein 1	Rattus norvegicus	21-25
9094007-1	1997	Expression of P-glycoprotein was studied in formalin-fixed tissue sections from 75 materials with an immunoperoxidase (ABC) method using the monoclonal antibody MRK-16.	Formaldehyde	44-52	ATP binding cassette subfamily B member 1	Homo sapiens	14-28
9028963-2	1997	This report describes an immunocytochemical study of the distribution of ALK and NPM-ALK proteins using a new monoclonal antibody, ALK1, that recognizes a formalin resistant epitope in both the 80-kD NPM-ALK chimeric and the 200-kD normal human ALK proteins.	Formaldehyde	155-163	ALK receptor tyrosine kinase	Homo sapiens	73-76
9071734-0	1997	A rapid and nonisotopic method for the screening and sequencing of p53 gene mutations in formalin-fixed, paraffin-embedded tumors.	Formaldehyde	89-97	tumor protein p53	Homo sapiens	67-70
9071734-2	1997	In this study, we describe a sensitive, rapid, nonisotopic and inexpensive procedure for the polymerase chain reaction (PCR)-single-stranded conformational polymorphism (SSCP) detection and subsequent sequencing of p53 mutations in formalin-fixed and paraffin-embedded tumor (PET) samples.	Formaldehyde	232-240	tumor protein p53	Homo sapiens	215-218
10743081-2	1997	METHODS: Four-stage peroxidase antiperoxidase complex (PAP) method was applied to comparatively investigate the expression and distribution of Bcl-2 protein in formalin-fixed, paraffin-embedded lymph node tissue comprising 12 cases of reactive follicular hyperplasia and 71 cases of NHL.	Formaldehyde	160-168	BCL2 apoptosis regulator	Homo sapiens	143-148
9076780-5	1997	These findings were correlated with the percentage of B- and T-cells in the lesions as well as with the number of cells that demonstrated staining for PCNA in formalin-fixed tissue.	Formaldehyde	159-167	proliferating cell nuclear antigen	Homo sapiens	151-155
9028963-2	1997	This report describes an immunocytochemical study of the distribution of ALK and NPM-ALK proteins using a new monoclonal antibody, ALK1, that recognizes a formalin resistant epitope in both the 80-kD NPM-ALK chimeric and the 200-kD normal human ALK proteins.	Formaldehyde	155-163	nucleophosmin 1	Homo sapiens	81-84
9028963-2	1997	This report describes an immunocytochemical study of the distribution of ALK and NPM-ALK proteins using a new monoclonal antibody, ALK1, that recognizes a formalin resistant epitope in both the 80-kD NPM-ALK chimeric and the 200-kD normal human ALK proteins.	Formaldehyde	155-163	ALK receptor tyrosine kinase	Homo sapiens	85-88
9028963-2	1997	This report describes an immunocytochemical study of the distribution of ALK and NPM-ALK proteins using a new monoclonal antibody, ALK1, that recognizes a formalin resistant epitope in both the 80-kD NPM-ALK chimeric and the 200-kD normal human ALK proteins.	Formaldehyde	155-163	activin A receptor like type 1	Homo sapiens	131-135
9028963-2	1997	This report describes an immunocytochemical study of the distribution of ALK and NPM-ALK proteins using a new monoclonal antibody, ALK1, that recognizes a formalin resistant epitope in both the 80-kD NPM-ALK chimeric and the 200-kD normal human ALK proteins.	Formaldehyde	155-163	nucleophosmin 1	Homo sapiens	200-203
9028963-2	1997	This report describes an immunocytochemical study of the distribution of ALK and NPM-ALK proteins using a new monoclonal antibody, ALK1, that recognizes a formalin resistant epitope in both the 80-kD NPM-ALK chimeric and the 200-kD normal human ALK proteins.	Formaldehyde	155-163	ALK receptor tyrosine kinase	Homo sapiens	85-88
9028963-2	1997	This report describes an immunocytochemical study of the distribution of ALK and NPM-ALK proteins using a new monoclonal antibody, ALK1, that recognizes a formalin resistant epitope in both the 80-kD NPM-ALK chimeric and the 200-kD normal human ALK proteins.	Formaldehyde	155-163	ALK receptor tyrosine kinase	Homo sapiens	85-88
9147067-0	1997	A novel monoclonal antibody, RM-4, specifically recognizes rat macrophages and dendritic cells in formalin-fixed, paraffin-embedded tissues.	Formaldehyde	98-106	DNA-damage inducible transcript 3	Rattus norvegicus	29-33
9037564-7	1997	These data suggest that whereas PCNA immunohistochemistry is satisfactory when carefully controlled in large chemopreventive studies, the Mib-1 mAb to Ki-67 is superior to PCNA antibodies in immunostaining proliferating cells in the formalin-fixed human colon.	Formaldehyde	233-241	MIB E3 ubiquitin protein ligase 1	Homo sapiens	138-143
9058631-4	1997	METHODS: The p53 expression in tumour tissue was studied by immunohistochemistry using CM1 polyclonal rabbit antibody and formalin-fixed, paraffin-embedded material.	Formaldehyde	122-130	tumor protein p53	Homo sapiens	13-16
9147067-5	1997	The immunoreactivity of RM-4 was well preserved not only in frozen sections but also in formalin-fixed, paraffin-embedded tissues.	Formaldehyde	88-96	DNA-damage inducible transcript 3	Rattus norvegicus	24-28
9812827-3	1997	Injection of formalin in the hindpaw induced pain response and increased the SP-LI, which could be inhibited by injection of SST.	Formaldehyde	13-21	somatostatin	Homo sapiens	125-128
9058292-0	1997	Detection of c-Ki-ras oncogene mutation in gastric adenomas with formalin-fixed, paraffin-embedded biopsy materials.	Formaldehyde	65-73	KRAS proto-oncogene, GTPase	Homo sapiens	13-21
9018047-2	1997	chi chi ADH catalyzes the oxidation of long-chain alcohols such as omega-hydroxy fatty acids as well as S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione.	Formaldehyde	162-174	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	8-11
9083512-1	1997	We evaluated the expression of MDR1/p-glycoprotein in paediatric tumours using reverse transcriptase polymerase chain reaction (RT-PCR), RNA dot blot analysis, and immunohistochemistry on formalin fixed paraffin-embedded material with JSB-1 and C-219 monoclonal antibodies, and compared these three techniques.	Formaldehyde	188-196	ATP binding cassette subfamily B member 1	Homo sapiens	31-35
9066650-2	1997	Two mouse anti-human monoclonal antibodies (MoABs) were employed for the detection of the nuclear antigen (Ki-67) present during proliferation in frozen sections and proliferating cell nuclear antigen (PCNA) expression in formalin fixed, paraffin embedded tissue sections.	Formaldehyde	222-230	proliferating cell nuclear antigen	Homo sapiens	202-206
8980360-3	1997	Genomic p53 was amplified with the polymerase chain reaction (PCR) from formalin-fixed, paraffin-embedded tissues.	Formaldehyde	72-80	tumor protein p53	Homo sapiens	8-11
9121675-0	1997	A contribution of neurokinin-1 receptor to formalin-induced c-fos expression in the rat spinal dorsal horn.	Formaldehyde	43-51	tachykinin receptor 1	Rattus norvegicus	18-39
9121675-0	1997	A contribution of neurokinin-1 receptor to formalin-induced c-fos expression in the rat spinal dorsal horn.	Formaldehyde	43-51	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	60-65
9121675-1	1997	Formalin applied to a hindpaw of the rat resulted in c-fos expression in the spinal dorsal horn neurons on the ipsilateral side of stimulation.	Formaldehyde	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	53-58
9276005-0	1997	Immune response prevalence to formaldehyde-human serum albumin molecular adduct in a healthy population.	Formaldehyde	30-42	albumin	Homo sapiens	49-62
9012438-6	1997	The reactivity of the octapeptide series with antisera raised to purified SEB and to formaldehyde-inactivated SEB has been used to locate several antigenic sites on native SEB and to identify antigenic differences in the toxoid.	Formaldehyde	85-97	SET binding protein 1	Homo sapiens	110-113
9012438-6	1997	The reactivity of the octapeptide series with antisera raised to purified SEB and to formaldehyde-inactivated SEB has been used to locate several antigenic sites on native SEB and to identify antigenic differences in the toxoid.	Formaldehyde	85-97	SET binding protein 1	Homo sapiens	110-113
9048228-7	1997	At all concentrations tested, the contact allergens isoeugenol and formaldehyde stimulated a Th1-type cytokine secretion profile, whereas a Th2-type pattern was induced following exposure to the chemical respiratory allergens cyanuric chloride and diphenylmethane diisocyanate.	Formaldehyde	67-79	negative elongation factor complex member C/D, Th1l	Mus musculus	93-96
9066700-1	1997	The MIB1 monoclonal antibody which is used as a marker of cell proliferation was studied by immunohistochemistry on formalin-fixed and paraffin embedded biopsy specimens of lymph nodes in 40 high- and 46 lowgrade cases of non-Hodgkin"s lymphomas (NHL) classified according to the Kiel classification.	Formaldehyde	116-124	MIB E3 ubiquitin protein ligase 1	Homo sapiens	4-8
9332493-2	1997	On a series of patients with non-Hodgkin"s lymphoma, we used a Ki67 equivalent monoclonal antibody, the recently proposed MIB-1, on formalin-fixed histopathological material using microwave antigen retrieval.	Formaldehyde	132-140	MIB E3 ubiquitin protein ligase 1	Homo sapiens	122-127
9332493-10	1997	In conclusion, the MIB-1 antibody provides prognostic information in non-Hodgkin"s lymphomas and has the main advantage that it can be used in formalin-fixed, paraffin-embedded specimens.	Formaldehyde	143-151	MIB E3 ubiquitin protein ligase 1	Homo sapiens	19-24
9043921-2	1997	To investigate a role for apoptosis at the maternal-fetal interface, we have immunolocalized the bcl-2 protein in formalin-fixed decidual and placental tissue collected from women undergoing surgical termination of pregnancy (n = 22), from women undergoing a sporadic miscarriage (n = 16) and from women with a history of recurrent pregnancy loss (more than three consecutive pregnancy losses; n = 22) undergoing a further miscarriage.	Formaldehyde	114-122	BCL2 apoptosis regulator	Homo sapiens	97-102
9113834-3	1997	Immunohistochemical staining for estrogen receptor (ER) and progesterone receptor (PR) was conducted using formalin-fixed paraffin-embedded sections of epididymides, by the avidinbiotin-peroxidase complex method.	Formaldehyde	107-115	progesterone receptor	Homo sapiens	83-85
9260591-4	1997	The expression of the proteins p53 and mdm2 was determined immunohistochemically using formalin-fixed, paraffin-embedded material.	Formaldehyde	87-95	tumor protein p53	Homo sapiens	31-34
9260591-4	1997	The expression of the proteins p53 and mdm2 was determined immunohistochemically using formalin-fixed, paraffin-embedded material.	Formaldehyde	87-95	MDM2 proto-oncogene	Homo sapiens	39-43
9027631-0	1997	Detection of CD44 splice variants in formalin-fixed, paraffin-embedded specimens of human skin cancer.	Formaldehyde	37-45	CD44 molecule (Indian blood group)	Homo sapiens	13-17
9027631-8	1997	We conclude that antigen retrieval unmasks certain epitopes in formalin-fixed, paraffin-embedded tissues, thus facilitating future research on the relevance of CD44s and CD44v expression for human skin carcinogenesis.	Formaldehyde	63-71	CD44 molecule (Indian blood group)	Homo sapiens	160-164
9276005-1	1997	Formaldehyde (F) covalently binds human serum albumin (HSA), giving rise to the molecular adduct, F-HSA, with F as a hapten.	Formaldehyde	0-12	albumin	Homo sapiens	40-53
9087919-9	1997	The results showed a high specificity and high sensitivity for detecting hog cholera Gp55 in formalin-fixed, paraffin embedded tissue samples.	Formaldehyde	93-101	neuroplastin	Homo sapiens	85-89
9342752-6	1997	Our results indicate that IHC could be applied for studies of p53 protein accumulation in archival formalin fixed, paraffin-embedded bladder tumours.	Formaldehyde	99-107	tumor protein p53	Homo sapiens	62-65
9016348-8	1997	Immunohistochemistry of formalin-fixed liver demonstrated a cytosolic localization of immunoreactive CDK1 and nuclear localization of immunoreactive PCNA in proliferating cells of WY14,643-treated rat livers.	Formaldehyde	24-32	cyclin-dependent kinase 1	Rattus norvegicus	101-105
9016348-8	1997	Immunohistochemistry of formalin-fixed liver demonstrated a cytosolic localization of immunoreactive CDK1 and nuclear localization of immunoreactive PCNA in proliferating cells of WY14,643-treated rat livers.	Formaldehyde	24-32	proliferating cell nuclear antigen	Rattus norvegicus	149-153
9060019-0	1997	Differential contribution of the two phases of the formalin test to the pattern of c-fos expression in the rat spinal cord: studies with remifentanil and lidocaine.	Formaldehyde	51-59	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	83-88
9035070-4	1997	With formalin-treated CPE, the IFN-producing and mitogenic activities were weakly found.	Formaldehyde	5-13	interferon alpha 1	Homo sapiens	31-34
9010458-4	1997	Point mutations in K-ras-2 were sought in archival, formalin-fixed tissue blocks from 24 patients with angiosarcoma.	Formaldehyde	52-60	KRAS proto-oncogene, GTPase	Homo sapiens	19-26
8989925-0	1997	Detection of thymidylate synthase gene expression levels in formalin-fixed paraffin embedded tissue by semiquantitative, nonradioactive reverse transcriptase polymerase chain reaction.	Formaldehyde	60-68	thymidylate synthetase	Homo sapiens	13-33
9007030-13	1997	In additional experiments, human CYP2A6 metabolized HMPA to formaldehyde, suggesting that this compound might cause nasal toxicity in humans.	Formaldehyde	60-72	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	33-39
9017235-2	1996	In 10% formalin-fixed paraffin-embedded tissue sections of five hypothalami, TRH mRNA-containing cells were found in several nuclei and areas.	Formaldehyde	7-15	thyrotropin releasing hormone	Homo sapiens	77-80
9041669-4	1997	The immunoglobulin isotype profile of the antibodies was predominantly IgG2a, similar to that induced by live virus infection but in contrast to the relative abundance of IgG1 antibodies observed after inoculation with formalin-inactivated whole virus.	Formaldehyde	219-227	LOC105243590	Mus musculus	171-175
8977710-1	1996	To elucidate involvement of proteinases in malignancy of keratinocytes, expression of cathepsin B, a cysteine proteinase, and cathepsin D, an aspartic proteinase, was ascertained in formalin-fixed paraffin-embedded specimens of normal skin, squamous cell carcinoma (SCC).	Formaldehyde	182-190	cathepsin B	Homo sapiens	86-97
8986205-2	1996	ADH isozyme activities were determined in endoscopic biopsies of the gastric corpus from 24 Japanese and 41 Caucasian men by starch gel electrophoresis and by comparing the reduction of m-nitrobenzaldehyde (a preferred substrate of sigma-ADH) with that of acetaldehyde (a preferred substrate of gamma-ADH) and the glutathione-dependent formaldehyde oxidation (a specific reaction of chi-ADH).	Formaldehyde	336-348	alcohol dehydrogenase 1A (class I), alpha polypeptide	Homo sapiens	0-3
8977710-1	1996	To elucidate involvement of proteinases in malignancy of keratinocytes, expression of cathepsin B, a cysteine proteinase, and cathepsin D, an aspartic proteinase, was ascertained in formalin-fixed paraffin-embedded specimens of normal skin, squamous cell carcinoma (SCC).	Formaldehyde	182-190	cathepsin D	Homo sapiens	126-137
8958295-2	1996	Both antibodies are able to detect pS2 in formalin-fixed, paraffin-embedded tissues.	Formaldehyde	42-50	trefoil factor 1	Homo sapiens	35-38
8958300-3	1996	Immunohistochemical expression of CD44 (standard [s] and variant [v6]) in benign and malignant nevomelanocytic lesions was assessed in formalin-fixed, paraffin-embedded tissue and was correlated with histological parameters and prognostic factors.	Formaldehyde	135-143	CD44 antigen	Mus musculus	34-38
8953691-5	1996	Trypsin was successful in highlighting PrP staining in formalin-fixed tissue.	Formaldehyde	55-63	major prion protein	Ovis aries	39-42
8983199-3	1996	We tested the viability of obtaining DNA sequence data from formalin-fixed, ethanol-preserved (FFEP) deep-sea crustaceans, and found that nucleotide sequences for mitochondrial 16S rRNA and COI genes can be recovered from FFEP collections of varying age, and that these sequences are unmodified compared with those derived from frozen specimens.	Formaldehyde	60-68	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	190-193
9121812-0	1996	The contribution of metabotropic glutamate receptors (mGluRs) to formalin-induced nociception.	Formaldehyde	65-73	glutamate metabotropic receptor 1	Rattus norvegicus	54-60
9014813-6	1996	It was found that the high levels of IL-4 and IL-10 secretion stimulated by TMA or MDI, and the lower levels of these cytokines induced by DNCB or formaldehyde, were in all cases dependent upon the presence of CD4- cells.	Formaldehyde	147-159	CD4 antigen	Mus musculus	210-213
9173362-0	1996	Immunophenotypic classification of canine malignant lymphoma on formalin-mixed paraffin wax-embedded tissue by means of CD3 and CD79a cell markers.	Formaldehyde	64-72	CD79a molecule	Canis lupus familiaris	128-133
9042261-6	1996	The immunohistochemical assay of formalin-fixed paraffin-embedded sections allows the retrospective analysis of ER and PgR in NSCLC.	Formaldehyde	33-41	progesterone receptor	Homo sapiens	119-122
8955930-9	1996	These data suggested that COX-2 is expressed in the central nervous system, including the spinal cord, and that COX-2 plays an important role in the spinal nociceptive transmission during the formalin test, but not during the hot plate test.	Formaldehyde	192-200	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	26-31
8955930-9	1996	These data suggested that COX-2 is expressed in the central nervous system, including the spinal cord, and that COX-2 plays an important role in the spinal nociceptive transmission during the formalin test, but not during the hot plate test.	Formaldehyde	192-200	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	112-117
8929476-3	1996	The expression of CD44 was investigated with the monoclonal antibody GKW.A3 in prostate cancer in formalin-fixed, paraffin-embedded tissue sections of (1) whole prostates from 50 patients with 74 prostate cancers; and (2) lymph node metastases from 14 patients.	Formaldehyde	98-106	CD44 molecule (Indian blood group)	Homo sapiens	18-22
8945907-5	1996	This NO exposure caused a 63 and 70% inhibition of the metabolism by smooth muscle catalase of both endogenously produced and exogenous (100 microM) H2O2, respectively, as measured by the H2O2-dependent cooxidation of methanol to formaldehyde.	Formaldehyde	230-242	catalase	Bos taurus	83-91
9042262-3	1996	The expression of p53 and bcl-2 gene products was studied immunohistochemically using formalin-fixed paraffinembedded tumor samples of 31 locally confined RCC of patients treated with radical nephrectomy.	Formaldehyde	86-94	tumor protein p53	Homo sapiens	18-21
9042262-3	1996	The expression of p53 and bcl-2 gene products was studied immunohistochemically using formalin-fixed paraffinembedded tumor samples of 31 locally confined RCC of patients treated with radical nephrectomy.	Formaldehyde	86-94	BCL2 apoptosis regulator	Homo sapiens	26-31
8892832-0	1996	S-formylglutathione hydrolase of Paracoccus denitrificans is homologous to human esterase D: a universal pathway for formaldehyde detoxification?	Formaldehyde	117-129	esterase D	Homo sapiens	0-29
8957552-1	1996	A rapid enhanced polymer one-step staining for proliferating cell nuclear antigen (EPOS-PCNA) in formalin fixed, paraffin embedded sections of tongue squamous cell carcinoma is described.	Formaldehyde	97-105	proliferating cell nuclear antigen	Homo sapiens	47-81
8957552-1	1996	A rapid enhanced polymer one-step staining for proliferating cell nuclear antigen (EPOS-PCNA) in formalin fixed, paraffin embedded sections of tongue squamous cell carcinoma is described.	Formaldehyde	97-105	proliferating cell nuclear antigen	Homo sapiens	83-92
8961585-3	1996	The recently released CD8 antiserum required microwave antigen retrieval of formalin-fixed, paraffin-embedded tissue to label lymphocytes.	Formaldehyde	76-84	CD8a molecule	Homo sapiens	22-25
8892832-0	1996	S-formylglutathione hydrolase of Paracoccus denitrificans is homologous to human esterase D: a universal pathway for formaldehyde detoxification?	Formaldehyde	117-129	esterase D	Homo sapiens	81-91
8892832-5	1996	S-Formylglutathione hydrolase appears to be part of a formaldehyde detoxification pathway that is universal in nature.	Formaldehyde	54-66	esterase D	Homo sapiens	0-29
8918900-1	1996	The relationship between expression of the c-erbB-2 proto-oncogene and the biology of breast cancer has been investigated widely, most studies using immunohistochemistry in formalin-fixed, paraffin-embedded tissues.	Formaldehyde	173-181	erb-b2 receptor tyrosine kinase 2	Homo sapiens	43-51
8892899-5	1996	The pulmonary eosinophilia was similar to that induced by a facsimile of a formalin-inactivated vaccine used in previous clinical trials and was prevented by prior in vivo treatment with anti-IL-5 but not with control immunoglobulin G or anti-IFN-gamma neutralizing monoclonal antibodies.	Formaldehyde	75-83	interleukin 5	Homo sapiens	192-196
8997010-1	1996	Using a polyclonal antibody against the c-erbB-2 gene product, an immunohistochemical study on the expression of c-erbB-2 oncoprotein was performed in routine formalin-fixed, paraffin-embedded tissue sections from 119 patients with primary breast cancer.	Formaldehyde	159-167	erb-b2 receptor tyrosine kinase 2	Homo sapiens	113-121
9387524-2	1996	METHODS: The amplification and expression of c-erbB2 oncogene were determined from formalin-fixed, paraffin-embedded tissues of 25 normal, 31 hyperplastic, and 72 malignant samples of the endometrium in 128 patients, using differential polymerase chain reaction (DPCR) and an immunohistochemical technique.	Formaldehyde	83-91	erb-b2 receptor tyrosine kinase 2	Homo sapiens	45-52
8940694-12	1996	It was indicated that this PCNA-labeled rate, which can be determined with formalin-fixed specimens, is useful for evaluating the degree of biological malignancy of ovarian cancer.	Formaldehyde	75-83	proliferating cell nuclear antigen	Homo sapiens	27-31
8913350-1	1996	Dilute formalin injected into the rat hindpaw as a nociceptive stimulus increases neurokinin-1 receptor (NK-1R) mRNA levels in the dorsal horn of the spinal cord.	Formaldehyde	7-15	tachykinin receptor 1	Rattus norvegicus	82-103
8913350-1	1996	Dilute formalin injected into the rat hindpaw as a nociceptive stimulus increases neurokinin-1 receptor (NK-1R) mRNA levels in the dorsal horn of the spinal cord.	Formaldehyde	7-15	tachykinin receptor 1	Rattus norvegicus	105-110
8913350-6	1996	In formalin-treated animals, the temporal pattern of peak pre-mRNA levels compared with mature mRNA indicated that chemogenic nociception either activates transcription of the NK-1R gene or decreases the rate of pre-mRNA splicing.	Formaldehyde	3-11	tachykinin receptor 1	Rattus norvegicus	176-181
8913350-7	1996	In the ipsilateral lumbar dorsal hom, NK-1R mRNA levels were significantly increased at 2 and 6 hr after formalin injection.	Formaldehyde	105-113	tachykinin receptor 1	Rattus norvegicus	38-43
8913350-8	1996	Levels of the NK-1R pre-mRNA containing both introns A and B were significantly increased 1 hr after formalin treatment, and levels of NK-1R pre-mRNAs containing intron A were significantly elevated at 2 hr after formalin treatment.	Formaldehyde	101-109	tachykinin receptor 1	Rattus norvegicus	14-19
8913350-8	1996	Levels of the NK-1R pre-mRNA containing both introns A and B were significantly increased 1 hr after formalin treatment, and levels of NK-1R pre-mRNAs containing intron A were significantly elevated at 2 hr after formalin treatment.	Formaldehyde	213-221	tachykinin receptor 1	Rattus norvegicus	135-140
8913350-11	1996	Pretreatment with LY306,740 (but not LY307,679) completely blocked the formalin-induced increase in dorsal horn NK-1R mRNA levels and significantly reduced formalin-induced behavioral activity.	Formaldehyde	71-79	tachykinin receptor 1	Rattus norvegicus	112-117
8815937-8	1996	A significant reduction in the number of Fos-like immunoreactive neurons was found ipsilateral to the formalin stimulus in nociresponsive areas of the dorsal horn after on-site injections of morphine into the RAIC.	Formaldehyde	102-110	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	41-44
8902840-4	1996	Sections of formalin-fixed, paraffin-embedded tissue pretreated by a citric acid monohydrate antigen retrieval method were immunostained with the mouse monoclonal antibody MIB-1, which detects the Ki-67 antigen in formalin-fixed tissue.	Formaldehyde	12-20	MIB E3 ubiquitin protein ligase 1	Homo sapiens	172-177
8988849-7	1996	We find that TGF-beta will not solely upregulate IgA production from noncommitted precursors (sIgM+) in coculture with mitogen or with formalin fixed Staphylococcus cowan Strain I (SAC), but does have positive effects on IgA production in the presence of both IL-2 and IL-10.	Formaldehyde	135-143	transforming growth factor, beta 1	Mus musculus	13-21
8813074-1	1996	We developed a new, highly specific antibody that localizes gamma-glutamyl transpeptidase (GGT) in formalin-fixed sections of human tissue.	Formaldehyde	99-107	inactive glutathione hydrolase 2	Homo sapiens	60-89
8813074-1	1996	We developed a new, highly specific antibody that localizes gamma-glutamyl transpeptidase (GGT) in formalin-fixed sections of human tissue.	Formaldehyde	99-107	inactive glutathione hydrolase 2	Homo sapiens	91-94
8813082-2	1996	In this study we demonstrate the potential use of NeuN as a diagnostic neuronal marker using a wide range of formalin-fixed, paraffin-embedded human surgical and autopsy specimens from the central and peripheral nervous system.	Formaldehyde	109-117	RNA binding fox-1 homolog 3	Homo sapiens	50-54
8813082-10	1996	The results indicate that NeuN immunoreactivity is a sensitive and specific neuronal marker in formalin-fixed, paraffin-embedded tissues, and may be useful in diagnostic histopathology.	Formaldehyde	95-103	RNA binding fox-1 homolog 3	Homo sapiens	26-30
8813086-0	1996	Amplification of human beta-actin gene by the reverse transcriptase-polymerase chain reaction: implications for assessment of RNA from formalin-fixed, paraffin-embedded material.	Formaldehyde	135-143	POTE ankyrin domain family member F	Homo sapiens	23-33
11667608-2	1996	The addition reactions of formaldehyde with (1,1-difluoroallyl)lithium and (1,1-dichloroallyl)lithium and -potassium (and corresponding free anions) have been investigated at the HF and MP2 levels of theory.	Formaldehyde	26-38	tryptase pseudogene 1	Homo sapiens	186-189
8957065-3	1996	Moreover, c-met protein was demonstrated in 34 (72.3%) of 47 surgically resected adenocarcinomas, 20 (38.5%) of 52 squamous cell carcinomas and 3 of 5 others, and the results were mostly confirmed immunohistochemically in formalin-fixed and paraffin-embedded tumors of the same case.	Formaldehyde	222-230	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	10-15
8895870-0	1996	Formalin-induced changes in adrenocorticotropic hormone and corticosterone plasma levels and hippocampal choline acetyltransferase activity in male and female rats.	Formaldehyde	0-8	choline O-acetyltransferase	Rattus norvegicus	105-130
8780389-6	1996	This sensitive method allows the detection of Pgp in capillary endothelial cells of normal brain in conventional paraffin sections after formalin fixation.	Formaldehyde	137-145	phosphoglycolate phosphatase	Homo sapiens	46-49
8951939-0	1996	Nitric oxide mediates long-term hyperalgesic and antinociceptive effects of the N-terminus of substance P in the formalin assay in mice.	Formaldehyde	113-121	tachykinin 1	Mus musculus	94-105
8958547-1	1996	A new monoclonal antibody against estrogen receptor (ID5, Dako) has shown promising results when applied to formalin fixed, paraffin embedded tissue.	Formaldehyde	108-116	estrogen receptor 1	Homo sapiens	34-51
8917707-0	1996	The tumour-associated antigen MAGE-1 is detectable in formalin-fixed paraffin sections of malignant melanoma.	Formaldehyde	54-62	MAGE family member A1	Homo sapiens	30-36
8784279-4	1996	METHODS: MIB-1 reactivity (% total tumor nuclei) was assessed in 34 formalin-fixed, paraffin-embedded primary cutaneous melanomas and correlated with metastatic potential and overall survival (follow-up, 10.5 +/- 1.8 years).	Formaldehyde	68-76	MIB E3 ubiquitin protein ligase 1	Homo sapiens	9-14
8872423-0	1996	The suppression of formalin-induced fos expression by different anesthetic agents in the infant rat.	Formaldehyde	19-27	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	36-39
8872423-3	1996	The expression of the c-fos immediate early gene following formalin injection into the hindpaw was used as a marker for neuronal activity.	Formaldehyde	59-67	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	22-27
8816885-0	1996	Immunohistochemical detection of p21waf1/cip1/sdi1 and p53 proteins in formalin-fixed, paraffin-embedded tissue sections of colorectal carcinoma.	Formaldehyde	71-79	cyclin dependent kinase inhibitor 1A	Homo sapiens	33-45
8895247-0	1996	Enantioselective inhibition of the formalin paw late phase by the NK1 receptor antagonist L-733,060 in gerbils.	Formaldehyde	35-43	tachykinin receptor 1	Homo sapiens	66-78
8797687-3	1996	Anti-IFN-alpha immunization consisted of four-six intramuscular injections 1 month apart of a water-in-oil emulsion of 500 micrograms formalin-inactivated recombinant IFN-alpha-2b (iIFN-alpha) followed by intramuscular injections of 250 micrograms iIFN-alpha adsorbed onto calcium phosphate every 3 months.	Formaldehyde	134-142	interferon alpha 1	Homo sapiens	167-176
8870051-0	1996	Antinociceptive effects of repeated systemic injections of calcitonin in formalin-induced hyperalgesic rats.	Formaldehyde	73-81	calcitonin-related polypeptide alpha	Rattus norvegicus	59-69
8890294-2	1996	Intraplantar injection of formalin (5%, 100 microliters in saline) was associated with a high level of spinal c-Fos immunoreactivity and a peripheral paw and ankle edema, as assessed at 3 h after formalin administration.	Formaldehyde	26-34	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	110-115
8890294-3	1996	For the two experimental series, the control number of formalin-evoked Fos-like immunoreactive (Fos-LI) neurons were 174 +/- 6 and 193 +/- 18 (means +/- SE) Fos-LI neurons per 40-microns section of the lumbar segment L4-L5 of the rat spinal cord.	Formaldehyde	55-63	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	71-74
8890294-3	1996	For the two experimental series, the control number of formalin-evoked Fos-like immunoreactive (Fos-LI) neurons were 174 +/- 6 and 193 +/- 18 (means +/- SE) Fos-LI neurons per 40-microns section of the lumbar segment L4-L5 of the rat spinal cord.	Formaldehyde	55-63	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	96-99
8890294-3	1996	For the two experimental series, the control number of formalin-evoked Fos-like immunoreactive (Fos-LI) neurons were 174 +/- 6 and 193 +/- 18 (means +/- SE) Fos-LI neurons per 40-microns section of the lumbar segment L4-L5 of the rat spinal cord.	Formaldehyde	55-63	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	96-99
8890294-8	1996	Laminar analysis of the regional effect of RP67580 on formalin-evoked Fos-LI neurons illustrated that the number of superficial and deep laminae Fos-LI neurons were attenuated to a similar extent by RP67580.	Formaldehyde	54-62	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	70-73
8890294-10	1996	Prior intravenous administration of RP68651 (1.5 mg/kg), the inactive isomer of RP67580, produced only a small reduction in the total number of formalin-evoked Fos-LI neurons (84 +/- 5% of the control number of formalin-evoked Fos-LI neurons (P &lt; 0.05).	Formaldehyde	144-152	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	160-163
8890294-11	1996	The effect of RP68651 on the number of formalin-evoked Fos-LI neurons was significantly smaller (P &lt; 0.01) than the effect of the equivalent concentration of RP67580, the active isomer.	Formaldehyde	39-47	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	55-58
8890294-15	1996	Laminar analysis illustrated that coadministered RP67580 and (+)-HA966 reduced the number of formalin-evoked Fos-LI neurons in the superficial and deep laminae to a similar extent.	Formaldehyde	93-101	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	109-112
8890294-21	1996	The second part of our study suggests that the previously reported NK1/NMDA-receptor interactions contribute to formalin-evoked spinal c-Fos expression and consequently may contribute to the longer term spinal neuroplasticity associated with inflammatory nociceptive processing.	Formaldehyde	112-120	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	135-140
8751991-6	1996	In the modified assay, the enzyme formaldehyde dehydrogenase (FDH) and its co-factor, NAD+ are added in large excess during the exposure period so that any formaldehyde produced in the system is rapidly converted to formic acid which is not genotoxic.	Formaldehyde	34-46	alcohol dehydrogenase 5 (class III), chi polypeptide	Mus musculus	62-65
8895247-1	1996	Intravenous administration of the NK1 receptor antagonist L-733,060 to gerbils 3 h before intraplantar injection of formalin caused a dose-dependent and complete inhibition of the late, but not early, phase nociceptive response (paw licking).	Formaldehyde	116-124	tachykinin receptor 1	Homo sapiens	34-46
8754651-3	1996	In the present study, 58 cases of invasive breast carcinomas were tested for vimentin on formaldehyde fixed paraffin embedded sections.	Formaldehyde	89-101	vimentin	Homo sapiens	77-85
8879300-2	1996	The accumulation of p53 protein was studied immunohistochemically using monoclonal antibody BP53-12 on formalin-fixed paraffin-embedded sections of 36 KS lesions, of which 14 were classified histologically as early type and 22 as spindle-cell or mixed type.	Formaldehyde	103-111	tumor protein p53	Homo sapiens	20-23
8864660-3	1996	Here, we show that colocalization of hsp90 with microtubules is seen after long-term but not short-term fixation of rat pulmonary endothelial cells with formaldehyde.	Formaldehyde	153-165	heat shock protein 90 alpha family class A member 1	Rattus norvegicus	37-42
8881915-2	1996	METHODS: Expression of p53 was evaluated immunocytochemically in a retrospective study of formalin fixed, paraffin wax embedded tissue.	Formaldehyde	90-98	tumor protein p53	Homo sapiens	23-26
8756378-3	1996	METHODS: Proliferation activity was investigated immunohistochemically using monoclonal antibody MIB-1 in formalin fixed, paraffin embedded tissues obtained from 67 specimens of renal pelvic and ureteral cancer.	Formaldehyde	106-114	MIB E3 ubiquitin protein ligase 1	Homo sapiens	97-102
8758921-4	1996	Of the 17 anti-CD43 mAbs used, 9 reacted with leukocytes in paraffin-fixed formalin-embedded lymph node tissues.	Formaldehyde	75-83	sialophorin	Homo sapiens	15-19
8872149-1	1996	The aim of this study was to evaluate the utility of a new commercially available antibody to thrombomodulin as an endothelial marker in formalin-fixed paraffin-embedded tissue.	Formaldehyde	137-145	thrombomodulin	Homo sapiens	94-108
8659718-10	1996	These data indicate that a CCK-B receptor antagonist, but not a CCK-A receptor antagonist, produces an antinociceptive effect in the rat formalin test.	Formaldehyde	137-145	cholecystokinin B receptor	Rattus norvegicus	27-41
8880857-4	1996	In addition, these same doses of L-NAME reduced formalin-induced Fos-labeling in the ipsilateral dorsal gray matter (as compared to the contralateral gray matter).	Formaldehyde	48-56	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	65-68
8836617-7	1996	The increase in vascular permeability induced by formaldehyde in the rat airway was mediated predominantly by NK1 receptor stimulation.	Formaldehyde	49-61	tachykinin receptor 1	Rattus norvegicus	110-122
8698319-2	1996	We applied immunohistochemistry using the avidin-biotin-complex technique to examine the presence of parathyroid hormone-related protein (PTHrP) in formalin-fixed and paraffin-embedded sections of tissue from a case of sclerosing hepatic carcinoma obtained at autopsy.	Formaldehyde	148-156	parathyroid hormone like hormone	Homo sapiens	101-136
8663952-2	1996	OBJECTIVE: To demonstrate how the detection of p53 protein in formaldehyde-fixed, paraffin-embedded oropharyngeal carcinoma may be used as a factor in estimating prognosis.	Formaldehyde	62-74	tumor protein p53	Homo sapiens	47-50
8698319-2	1996	We applied immunohistochemistry using the avidin-biotin-complex technique to examine the presence of parathyroid hormone-related protein (PTHrP) in formalin-fixed and paraffin-embedded sections of tissue from a case of sclerosing hepatic carcinoma obtained at autopsy.	Formaldehyde	148-156	parathyroid hormone like hormone	Homo sapiens	138-143
8675997-0	1996	Immunohistochemical detection of thrombospondin-1 in formalin-fixed, paraffin-embedded tissue.	Formaldehyde	53-61	thrombospondin 1	Homo sapiens	33-49
8675997-5	1996	Our objective in this study was to determine the optimal antigen retrieval (AR) protocol for detection of TSP in formalin-fixed, paraffin-embedded tissue by using tissue sections from patients with invasive transitional cell carcinoma of the bladder.	Formaldehyde	113-121	thrombospondin 1	Homo sapiens	106-109
8640700-3	1996	Lately, new monoclonal antibodies derived by recombinant ER technology have been developed that work well on paraffin embedded, formalin fixed tissue sections.	Formaldehyde	128-136	estrogen receptor 1	Homo sapiens	57-59
8774494-3	1996	The immunohistochemical detection of pRB expression in formalin-paraffin sections of human cancer has potential advantages of convenience, economy, and compatibility with routine surgical pathology practice.	Formaldehyde	55-63	RB transcriptional corepressor 1	Homo sapiens	37-40
8774494-10	1996	A consistent intensity of immunohistochemical staining for pRB was achieved using the identified optimal AR protocol on formalin-paraffin sections.	Formaldehyde	120-128	RB transcriptional corepressor 1	Homo sapiens	59-62
21594450-2	1996	In this retrospective study the pS2 protein expression was detected by immunohistochemistry in formalin-fixed, paraffin-embedded breast cancer sections from 219 patients with primary breast cancer.	Formaldehyde	95-103	taste 2 receptor member 64 pseudogene	Homo sapiens	32-35
8774494-0	1996	Development of an optimal protocol for antigen retrieval: a "test battery" approach exemplified with reference to the staining of retinoblastoma protein (pRB) in formalin-fixed paraffin sections.	Formaldehyde	162-170	RB transcriptional corepressor 1	Homo sapiens	154-157
8675145-2	1996	To evaluate the clinical implications and effect of interferon alfa (IFN-alpha) therapy on hepatic expression of HCV RNA, HCV RNA was detected by in situ reverse-transcription polymerase chain reaction (IS-RT-PCR) in formalin-fixed paraffin-embedded liver sections from 26 patients with chronic hepatitis C. Results were compared with RT-PCR of HCV RNA extracted from liver sections/tissue.	Formaldehyde	217-225	interferon alpha 1	Homo sapiens	69-78
8805130-0	1996	Induction of spinal cord neuronal nitric oxide synthase (NOS) after formalin injection in the rat hind paw.	Formaldehyde	68-76	nitric oxide synthase 1	Rattus norvegicus	25-55
8805130-8	1996	We investigated the hypothesis that hind paw injection of formalin increases the number of dorsal horn neuronal nitric oxide synthase (nNOS) containing neurons.	Formaldehyde	58-66	nitric oxide synthase 1	Rattus norvegicus	103-133
8805130-8	1996	We investigated the hypothesis that hind paw injection of formalin increases the number of dorsal horn neuronal nitric oxide synthase (nNOS) containing neurons.	Formaldehyde	58-66	nitric oxide synthase 1	Rattus norvegicus	135-139
8805130-9	1996	Results showed a bilateral increase in the number of nNOS-positive neurons at the L4-5 dorsal horn area following formalin injection.	Formaldehyde	114-122	nitric oxide synthase 1	Rattus norvegicus	53-57
8805130-11	1996	This upregulation of nNOS following formalin stimulation of the hind paw suggested that nitric oxide (NO) may play a role in the central mechanism of hyperalgesia that follows peripheral inflammation.	Formaldehyde	36-44	nitric oxide synthase 1	Rattus norvegicus	21-25
9816271-3	1996	We developed procedures to examine the status of the K-ras gene by ASO-h and by single-strand conformation polymorphism assay of DNA obtained from formalin-fixed paraffin-embedded tumors.	Formaldehyde	147-155	KRAS proto-oncogene, GTPase	Homo sapiens	53-58
8782209-10	1996	We used the DO-7 monoclonal antibody reactive for the N-terminal of the p53 protein on formalin-fixed paraffin-embedded tissue.	Formaldehyde	87-95	tumor protein p53	Homo sapiens	72-75
8661200-3	1996	Serial sections obtained from formalin-fixed porcine mediastinal tissue, incubated with either ET-1 or von Willebrand factor antibody and stained with avidin-biotin complex and peroxidase, demonstrated ET-1 in lymphatic vascular endothelium.	Formaldehyde	30-38	endothelin 1	Homo sapiens	202-206
8794404-4	1996	We also evaluated the effect of microwave pre-treatment of formalin-fixed, paraffin-embedded sections on the NCAM immunostaining and related the outcome to the postoperative clinical course of disease.	Formaldehyde	59-67	neural cell adhesion molecule 1	Homo sapiens	109-113
8688970-3	1996	The expression of cyclin D3 was studied immunohistochemically in archival formalin-fixed, paraffin-embedded specimens from normal organs obtained from three autopsy cases and 237 human primary pulmonary carcinomas.	Formaldehyde	74-82	cyclin D3	Homo sapiens	18-27
10330207-3	1996	Mutational analysis of p53 was performed retrospectively by means of topographic genotyping (TG), using formalin-fixed, paraffin-embedded tissue of the primary and recurrent tumor.	Formaldehyde	104-112	tumor protein p53	Homo sapiens	23-26
8829149-3	1996	Intrathecal administration of selective 5-HT3 receptor antagonists, granisetron (0.1-100 pmol/rat) and ondansetron (1-1000 pmol/rat), reduced the second phase of the formalin-induced aversive responses without affecting the first one.	Formaldehyde	166-174	5-hydroxytryptamine receptor 3A	Rattus norvegicus	40-54
8734902-2	1996	The present study aims to examine the variability in GFAP immunohistochemistry in formalin-fixed human brain.	Formaldehyde	82-90	glial fibrillary acidic protein	Homo sapiens	53-57
8782869-1	1996	Expression of the inducible transcription factor c-Fos has been examined in the lumbar spinal cord following noxious chemical stimulation (injection of 2% formalin) of the ankles or the ventral skin of the hindpaws of either normal rats, or monoarthritic rats during the chronic phase of the disease.	Formaldehyde	155-163	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	49-54
8782869-5	1996	One hour after formalin stimulation of the ankle or hindpaw skin of normal rats expression of c-Fos was observed throughout the ipsilateral, but not contralateral dorsal horn.	Formaldehyde	15-23	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	94-99
8782869-6	1996	Formalin stimulation of the inflamed ankle in four-week arthritic rats induced a 3-to-6 fold increase in c-Fos expression in the ipsilateral dorsal horn compared to formalin stimulation of the ankle in normal rats.	Formaldehyde	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	105-110
8782869-8	1996	Formalin stimulation of the contralateral ankle in monoarthritic rats (i.e. the non-inflamed ankle) induced an ipsilateral expression of c-Fos which was similar to that observed after stimulation of the arthritic ankle.	Formaldehyde	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	137-142
8782869-10	1996	Finally, formalin stimulation of the hindpaw skin (which was not inflamed) of the arthritic limb induced the same number of c-Fos labelled cells in the superficial laminae as did formalin stimulation of the skin of normal rats; but in the deep laminae there was a 1.6-fold increase in the number of labelled cells.	Formaldehyde	9-17	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	124-129
8734653-3	1996	METHODS: We attempted to retrieve the trichohyalin antigenicity in formalin-fixed, paraffin-embedded biopsy specimens that included normal skin as well as skin tumors such as trichofolliculoma and pilotricoma.	Formaldehyde	67-75	trichohyalin	Homo sapiens	38-50
8623923-0	1996	Monoclonal antibodies PG-B6a and PG-B6p recognize, respectively, a highly conserved and a formol-resistant epitope on the human BCL-6 protein amino-terminal region.	Formaldehyde	90-96	BCL6 transcription repressor	Homo sapiens	128-133
8641546-1	1996	We examined the expression of E-cadherin and collagenase type IV in formalin-fixed, paraffin-embedded specimens of human gastric carcinoma by an in situ mRNA hybridization (ISH) technique.	Formaldehyde	68-76	cadherin 1	Homo sapiens	30-40
8611709-4	1996	We have investigated LMP1 status in formalin-fixed, paraffin wax-embedded lymph nodes with HD involvement from 53 children and 48 adults from Kenya using immunohistochemical staining.	Formaldehyde	36-44	PDZ and LIM domain 7	Homo sapiens	21-25
8728481-0	1996	The effect of pituitary adenylate cyclase activating peptide (PACAP) on the nociceptive formalin test.	Formaldehyde	88-96	adenylate cyclase activating polypeptide 1	Homo sapiens	14-60
8627559-6	1996	Additionally, antisera to [Leu5]enkephalin and dynorphin also resulted in a significant increase in formalin-induced flinching, whereas antisera to [Met5]enkephalin had no effect.	Formaldehyde	100-108	proenkephalin	Rattus norvegicus	32-42
8627559-6	1996	Additionally, antisera to [Leu5]enkephalin and dynorphin also resulted in a significant increase in formalin-induced flinching, whereas antisera to [Met5]enkephalin had no effect.	Formaldehyde	100-108	proenkephalin	Rattus norvegicus	154-164
8627559-7	1996	On the basis of significant increases in formalin-induced flinching produced by 1) receptor-selective doses of delta and kappa, but not mu, opioid antagonists and 2) antisera to [Leu5]enkephalin and dynorphin A, but not [Met5]enkephalin, these data suggest the presence of an opioid inhibitory tone which acts to limit the intensity of the pain signal.	Formaldehyde	41-49	proenkephalin	Rattus norvegicus	184-194
8627559-7	1996	On the basis of significant increases in formalin-induced flinching produced by 1) receptor-selective doses of delta and kappa, but not mu, opioid antagonists and 2) antisera to [Leu5]enkephalin and dynorphin A, but not [Met5]enkephalin, these data suggest the presence of an opioid inhibitory tone which acts to limit the intensity of the pain signal.	Formaldehyde	41-49	proenkephalin	Rattus norvegicus	226-236
8627759-0	1996	Respiratory synctial virus infection in BALB/c mice previously immunized with formalin-inactivated virus induces enhanced pulmonary inflammatory response with a predominant Th2-like cytokine pattern.	Formaldehyde	78-86	heart and neural crest derivatives expressed 2	Mus musculus	173-176
8733771-4	1996	The bcl-2 protein was detected after antigen retrieval with bcl-2 monoclonal antibody using archival formalin-fixed, paraffin-embedded tissue material.	Formaldehyde	101-109	BCL2 apoptosis regulator	Homo sapiens	4-9
8737422-2	1996	Since the stomach is continually exposed to injurious chemicals, the present study examined whether application of acid (0.15 M HCl) and formalin (5%) to the gastric mucosa or serosal surface of the stomach stimulates c-fos transcription in the caudal thoracic spinal cord of anaesthetized rats.	Formaldehyde	137-145	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	218-223
8737422-5	1996	Application of acid to the serosal surface of the stomach was also unable to stimulate c-fos transcription, whereas serosal application of formalin led to substantial expression of c-fos messenger RNA in the superficial but also deeper laminae of the spinal dorsal horn when examined 45 min, but not 15 or 120 min, post-stimulation.	Formaldehyde	139-147	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	181-186
8737422-6	1996	The highest expression of c-fos messenger RNA was seen when formalin was injected subcutaneously into one hindpaw and c-fos transcription was examined in the lumbar spinal cord.	Formaldehyde	60-68	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	26-31
8608989-1	1996	We have used immunohistochemical staining to assess the expression of cyclin D1 in formalin-fixed sections of 345 breast carcinomas, dating back 20 years.	Formaldehyde	83-91	cyclin D1	Homo sapiens	70-79
8606380-5	1996	METHODS: Immunohistochemical analysis with a monoclonal antibody (DO7) specific for p53 protein was used to detect expression of the protein in formalin-fixed, paraffin-embedded tumor samples from 69 head and neck cancer patients treated with definitive local therapy (surgery and/or radiotherapy) between January 1980 and October 1983 at The University of Texas M. D. Anderson Cancer Center.	Formaldehyde	144-152	tumor protein p53	Homo sapiens	84-87
8735718-3	1996	Formalin-fixed, paraffin-embedded archival tissue from 87 carcinomas (Ta-T1 45 cases) and T2-T4 (42 cases) was immunostained (Strept ABC/HRP) with the NDPK-A monoclonal antibody (NDPK-A) against nm23-H1 protein.	Formaldehyde	0-8	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	151-157
8737966-4	1996	With the formalin test, it was found that the antinociception produced by the GABA-A antagonist, picrotoxin, and the GABA-B antagonist, phaclofen, was abolished when employed in combination.	Formaldehyde	9-17	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	78-84
8728481-0	1996	The effect of pituitary adenylate cyclase activating peptide (PACAP) on the nociceptive formalin test.	Formaldehyde	88-96	adenylate cyclase activating polypeptide 1	Homo sapiens	62-67
8728481-5	1996	Intrathecal PACAP-27 at 0.6 pmol suppressed the second phase response to formalin, while 5 pmol depressed both phases.	Formaldehyde	73-81	adenylate cyclase activating polypeptide 1	Homo sapiens	12-17
8728481-7	1996	Hence, the data suggest that the effect of PACAP-27 on formalin-induced pain-related behavior is specific.	Formaldehyde	55-63	adenylate cyclase activating polypeptide 1	Homo sapiens	43-48
8625499-11	1996	Cytochrome P450 2E1 catalyzed formation of formaldehyde and propionaldehyde from NDPA and NBPA, but did not catalyze formation of acetaldehyde or butyraldehyde.	Formaldehyde	43-55	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	0-19
8617478-3	1996	The authors postulated that the indolent variants of BCC, namely, the superficial and circumscribed subtypes, might exhibit greater bcl-2 expression than their aggressive counterparts, and used a monoclonal antibody to identify its protein product in formalin-fixed tissue from 30 BCCs.	Formaldehyde	251-259	BCL2 apoptosis regulator	Homo sapiens	132-137
8625422-0	1996	Overexpression of ADH1 confers hyper-resistance to formaldehyde in Saccharomyces cerevisiae.	Formaldehyde	51-63	alcohol dehydrogenase ADH1	Saccharomyces cerevisiae S288C	18-22
8625422-4	1996	Construction of an adh1-0 mutant revealed that yeast lacking a functional ADH1 gene is sensitive to formaldehyde.	Formaldehyde	100-112	alcohol dehydrogenase ADH1	Saccharomyces cerevisiae S288C	19-23
8625422-4	1996	Construction of an adh1-0 mutant revealed that yeast lacking a functional ADH1 gene is sensitive to formaldehyde.	Formaldehyde	100-112	alcohol dehydrogenase ADH1	Saccharomyces cerevisiae S288C	74-78
8625422-5	1996	While glutathione is essential for Adh5-mediated formaldehyde de-toxification, Adh1 reduced formaldehyde best in the absence of this thiol compound.	Formaldehyde	92-104	alcohol dehydrogenase ADH1	Saccharomyces cerevisiae S288C	79-83
8625422-6	1996	Evidence is presented that formaldehyde is a substrate for Adh1 in vivo and in vitro and that its cellular de-toxification employs a reductive step that may yield methanol.	Formaldehyde	27-39	alcohol dehydrogenase ADH1	Saccharomyces cerevisiae S288C	59-63
8695259-1	1996	The expression of mutated p53 protein was studied in paraffin-embedded, formalin-fixed tumour specimens from 183 women with endometrial carcinoma.	Formaldehyde	72-80	tumor protein p53	Homo sapiens	26-29
9156521-6	1996	We have shown clear amplification of VDR transcripts within sections of formalin-fixed paraffin-embedded human kidney and liver.	Formaldehyde	72-80	vitamin D receptor	Homo sapiens	37-40
8636375-11	1996	H19 imprinting was maintained in all 18 informative fresh-frozen and paraffin-embedded formalin-fixed samples.	Formaldehyde	87-95	H19 imprinted maternally expressed transcript	Homo sapiens	0-3
9388844-2	1996	METHOD: Using a rabbit polyclonal antibody against P16 (N-20), the expression of P16 protein was studied immunohistochemically on formalin fixed, paraffin embedded sections.	Formaldehyde	130-138	cyclin dependent kinase inhibitor 2A	Homo sapiens	81-84
8614221-4	1996	Immunohistochemical analysis for EGFr was performed on formalin-fixed, paraffin-embedded archival surgical specimens.	Formaldehyde	55-63	epidermal growth factor receptor	Homo sapiens	33-37
8857669-5	1996	Thus, MoAb MAT-1 could recognize the cells with melanogenic activity on routine formalin-fixed paraffin-embedded sections.	Formaldehyde	80-88	methionine adenosyltransferase 1A	Homo sapiens	11-16
8691320-1	1996	To examine the expression of p53 protein and gene alterations in oral epithelial lesions including epithelial dysplasias and primary squamous cell carcinomas, immunohistochemical and temperature gradient gel electrophoresis (TGGE) methods were applied to formalin-fixed and paraffin-embedded tissues.	Formaldehyde	255-263	tumor protein p53	Homo sapiens	29-32
8857669-0	1996	Monoclonal antibody MAT-1 against human tyrosinase can detect melanogenic cells on formalin-fixed paraffin-embedded sections.	Formaldehyde	83-91	methionine adenosyltransferase 1A	Homo sapiens	20-25
8857669-0	1996	Monoclonal antibody MAT-1 against human tyrosinase can detect melanogenic cells on formalin-fixed paraffin-embedded sections.	Formaldehyde	83-91	tyrosinase	Homo sapiens	40-50
8857669-1	1996	Immunohistochemical localization of tyrosinase was examined with a monoclonal antibody (MoAb MAT-1) against human tyrosinase on routine formalin-fixed paraffin-embedded sections of 3 normal skin specimens, 15 melanocytic tumors (6 pigmented nevi, 3 juvenile melanomas and 6 malignant melanomas) and 3 non-melanocytic tumors.	Formaldehyde	136-144	tyrosinase	Homo sapiens	36-46
8711933-3	1996	In this study, we investigated the immunohistochemical expression of p53 in formalin fixed paraffin embedded archival specimens of 36 extrahepatic bile duct cancers in which p53 expression was found in eighteen (50%) cases.	Formaldehyde	76-84	tumor protein p53	Homo sapiens	69-72
8740788-4	1996	Recent studies showed that overexpression of the cyclin D1 protein can be easily detected by immunohistochemistry (IHC) on formalin-fixed, paraffin embedded tissues.	Formaldehyde	123-131	cyclin D1	Homo sapiens	49-58
8731433-0	1996	Induction of interleukin-1 beta mRNA in the hypothalamus following subcutaneous injections of formalin into the rat hind paws.	Formaldehyde	94-102	interleukin 1 beta	Rattus norvegicus	13-31
8731433-1	1996	The induction of interleukin-1 beta (IL-1 beta) mRNA in the rat brain following subcutaneous injection of formalin into the hind paws was investigated by in situ hydridization.	Formaldehyde	106-114	interleukin 1 beta	Rattus norvegicus	17-35
8731433-1	1996	The induction of interleukin-1 beta (IL-1 beta) mRNA in the rat brain following subcutaneous injection of formalin into the hind paws was investigated by in situ hydridization.	Formaldehyde	106-114	interleukin 1 beta	Rattus norvegicus	37-46
8731433-2	1996	IL-1 beta mRNA was markedly induced in the hypothalamus after the injection of formalin into both hind paws.	Formaldehyde	79-87	interleukin 1 beta	Rattus norvegicus	0-9
8731433-5	1996	The present results suggest that IL-1 beta mRNA is induced in the glial cells of the hypothalamus by persistent pain which is caused by formalin injection.	Formaldehyde	136-144	interleukin 1 beta	Rattus norvegicus	33-42
8729664-0	1996	Exposure to gaseous formaldehyde induces IgE-mediated sensitization to formaldehyde in school-children.	Formaldehyde	20-32	immunoglobulin heavy constant epsilon	Homo sapiens	41-44
8611372-3	1996	After affinity purification, the antiserum specifically detected overexpression of cyclin D1 in formalin-fixed, paraffin-embedded tumour material also.	Formaldehyde	96-104	cyclin D1	Homo sapiens	83-92
8729664-0	1996	Exposure to gaseous formaldehyde induces IgE-mediated sensitization to formaldehyde in school-children.	Formaldehyde	71-83	immunoglobulin heavy constant epsilon	Homo sapiens	41-44
8729664-2	1996	Assessment of specific IgE to formaldehyde gave positive results in some children.	Formaldehyde	30-42	immunoglobulin heavy constant epsilon	Homo sapiens	23-26
8729664-3	1996	OBJECTIVE: Was IgE-mediated sensitization as well as symptoms in children associated with formaldehyde exposure at school?	Formaldehyde	90-102	immunoglobulin heavy constant epsilon	Homo sapiens	15-18
8729664-6	1996	Assessment of specific IgE to formaldehyde was done in all children.	Formaldehyde	30-42	immunoglobulin heavy constant epsilon	Homo sapiens	23-26
8729664-15	1996	However, elevated IgE levels to formaldehyde did not correlate with symptoms.	Formaldehyde	32-44	immunoglobulin heavy constant epsilon	Homo sapiens	18-21
8729664-17	1996	After transferral specific IgE to formaldehyde decreased significantly from 1.7 +/- 0.5 to 1.2 +/- 0.2 (P &lt; 0.002) as did the incidence of symptoms.	Formaldehyde	34-46	immunoglobulin heavy constant epsilon	Homo sapiens	27-30
8729664-18	1996	CONCLUSION: Gaseous formaldehyde, besides its irritant action, leads to IgE-mediated sensitization.	Formaldehyde	20-32	immunoglobulin heavy constant epsilon	Homo sapiens	72-75
8600035-1	1996	The immunohistochemical expression of bcl-2 and p53 proteins was evaluated in formalin-fixed, paraffin-embedded surgical specimens from 212 patients with primary gastric lymphoma.	Formaldehyde	78-86	BCL2 apoptosis regulator	Homo sapiens	38-43
8600370-5	1996	The MC GST metabolite formaldehyde was mutagenic in independent experiments, although the number of mutants induced was lower than with the MC.	Formaldehyde	22-34	hematopoietic prostaglandin D synthase	Mus musculus	7-10
8774640-5	1996	Overnight incubation of formalin-fixed tumor sections at 4 degree C with primary rabbit polyclonal IgG antibody to human nm23-H1/NDP kinase was followed by detection with standard ABC method.	Formaldehyde	24-32	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	121-128
8598357-2	1996	METHODS AND MATERIALS: Epidermal growth factor receptor protein expression was investigated immunohistochemically in formalin-fixed, paraffin-embedded surgical specimens of 55 glioblastoma multiforme, 14 anaplastic astrocytoma, and 2 astrocytomas given definitive irradiation.	Formaldehyde	117-125	epidermal growth factor receptor	Homo sapiens	23-55
8637203-2	1996	It has been demonstrated that ER and PgR detected by immunohistochemical methods in formalin-fixed paraffin-embedded tissue can be quantified by computerized image analysis.	Formaldehyde	84-92	progesterone receptor	Homo sapiens	37-40
8920635-10	1996	Recent studies showing that the endogenously-occurring aliphatic amines methylamine and aminoacetone are metabolized in vitro to formaldehyde and methylglyoxal, respectively, by SSAO in some animal (including human) tissues, suggest the possibility that toxicological consequences upon cellular function could result if such conversions occur in vivo.	Formaldehyde	129-141	amine oxidase copper containing 2	Homo sapiens	178-182
8778328-2	1996	This immunohistochemical study on formalin-fixed, paraffin-embedded material found p53 expression in 43 per cent (n = 51) of carcinomas using a monoclonal antibody (DO-1), whereas no immunoreactivity for p53 was present in tumour-associated non-neoplastic gastric mucosa or tumour stroma.	Formaldehyde	34-42	tumor protein p53	Homo sapiens	83-86
9008942-2	1996	The present work intends to compare specificity and sensitivity of IH and biochemical technique to assess nuclear estrogen receptor in formalin-fixed and paraffin-embedded mammary carcinoma samples.	Formaldehyde	135-143	estrogen receptor 1	Homo sapiens	114-131
8655691-4	1996	The addition of 0.1% buffered formaldehyde to the collagenase/dispase digestion of mucosal biopsy specimens from patients with inflammatory bowel disease enhances detection of CD3, CD11b, CD16, CD63, and CD14.	Formaldehyde	30-42	integrin subunit alpha M	Homo sapiens	181-186
8633403-3	1996	METHODS: Immunohistochemical staining for mutant p53 was performed on 40 formalin-fixed radical prostatectomy specimens.	Formaldehyde	73-81	tumor protein p53	Homo sapiens	49-52
8619913-2	1996	Polyacrylamide gel electrophoresis and gel filtration showed that heat denaturation converted ovalbumin to high Mr polymers, whereas formaldehyde/lysine-treated ovalbumin remained monomeric with only a small proportion forming oligomers.	Formaldehyde	133-145	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	161-170
8742318-10	1996	Activities of glutathione S-transferase and glutathione reductase after 3 days of exposure to acrolein, alone or in combination with formaldehyde and acetaldehyde, were depressed whereas the glutathione peroxidase activity was elevated.	Formaldehyde	133-145	hematopoietic prostaglandin D synthase	Rattus norvegicus	14-39
8742318-10	1996	Activities of glutathione S-transferase and glutathione reductase after 3 days of exposure to acrolein, alone or in combination with formaldehyde and acetaldehyde, were depressed whereas the glutathione peroxidase activity was elevated.	Formaldehyde	133-145	glutathione-disulfide reductase	Rattus norvegicus	44-65
8554110-3	1996	In this study, we evaluated the sensitivity and specificity of a CD56 antibody, 123C3, when applied on routine formalin-fixed, paraffin-embedded tissues for analysis of lymphomas, by comparing the staining results with those obtained on frozen tissues using the CD56 antibody NKH1.	Formaldehyde	111-119	neural cell adhesion molecule 1	Homo sapiens	65-69
8645360-2	1996	Methylamine can be converted by semicarbazide-sensitive amine oxidase (SSAO) to formaldehyde and hydrogen peroxide, which have been proven to be toxic towards cultured endothelial cells.	Formaldehyde	80-92	amine oxidase, copper containing 3	Mus musculus	32-69
8645360-2	1996	Methylamine can be converted by semicarbazide-sensitive amine oxidase (SSAO) to formaldehyde and hydrogen peroxide, which have been proven to be toxic towards cultured endothelial cells.	Formaldehyde	80-92	amine oxidase, copper containing 3	Mus musculus	71-75
16696044-1	1996	Aims-To study the possible accumulation of p53 protein in inverted papilloma of the urinary bladder.Methods-Formalin fixed, paraffin wax embedded sections from 14 cases of inverted papilloma of the urinary bladder were studied retrospectively.	Formaldehyde	108-116	tumor protein p53	Homo sapiens	43-46
8655691-4	1996	The addition of 0.1% buffered formaldehyde to the collagenase/dispase digestion of mucosal biopsy specimens from patients with inflammatory bowel disease enhances detection of CD3, CD11b, CD16, CD63, and CD14.	Formaldehyde	30-42	CD63 molecule	Homo sapiens	194-198
8920221-7	1996	Thus p53 antigen could be detected immunohistochemically in formalin-fixed and paraffin wax-embedded tissues of SCCs of domestic animals.	Formaldehyde	60-68	tumor protein p53	Equus caballus	5-8
8655691-4	1996	The addition of 0.1% buffered formaldehyde to the collagenase/dispase digestion of mucosal biopsy specimens from patients with inflammatory bowel disease enhances detection of CD3, CD11b, CD16, CD63, and CD14.	Formaldehyde	30-42	CD14 molecule	Homo sapiens	204-208
8632353-0	1996	Differential contribution of descending controls to the antinociceptive actions of kappa and mu opioids: an analysis of formalin-evoked C-fos expression.	Formaldehyde	120-128	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	136-141
8882643-6	1996	Computerized models of the PCR, solution-phase and in situ PCR on formalin-fixed DNA indicated that HCMV and beta-actin primers were efficient and specific.	Formaldehyde	66-74	POTE ankyrin domain family member F	Homo sapiens	109-119
8708945-4	1996	Contact-inhibited HGF were prepared and formalin-killed bacterial cells (Aa JP2, ATCC 29523 &amp; 33384 and Cr ATCC 33238) at 10(6)-10(9) were added to the HGF.	Formaldehyde	40-48	hepatocyte growth factor	Homo sapiens	18-21
8740613-6	1996	Following formalin (2.5%, 50 microliters) injection into their receptive fields, phase-1 activity was prominent in A beta and A delta fibers as well as in high-threshold C nociceptive afferent fibers.	Formaldehyde	10-18	amyloid beta precursor protein	Rattus norvegicus	115-121
9173910-3	1996	Here, we characterized the deposition of several A beta peptides and apolipoprotein E in formalin-fixed brain sections from 29 DS subjects between 3 and 73 years old.	Formaldehyde	89-97	amyloid beta precursor protein	Homo sapiens	49-55
8836295-2	1996	MIB-1 antibody has recently become available, which detects Ki-67 antigen even in the formalin-fixed paraffin-embedded specimens.	Formaldehyde	86-94	MIB E3 ubiquitin protein ligase 1	Homo sapiens	0-5
8871764-2	1996	We describe the immunohistochemical detection of tumor necrosis factor-alpha using formaldehyde fixed and paraffin embedded tissue and a polyclonal anti-serum with high tumor necrosis factor-alpha neutralising activity.	Formaldehyde	83-95	tumor necrosis factor	Homo sapiens	49-76
9431695-1	1996	Detection of various epitopes of the p53 and MDM-2 proteins, using new antibodies was performed on formalin-fixed and paraffin-embedded tissue samples from breast cancer and compared with results obtained using well-characterized antibodies.	Formaldehyde	99-107	tumor protein p53	Homo sapiens	37-40
9431695-1	1996	Detection of various epitopes of the p53 and MDM-2 proteins, using new antibodies was performed on formalin-fixed and paraffin-embedded tissue samples from breast cancer and compared with results obtained using well-characterized antibodies.	Formaldehyde	99-107	MDM2 proto-oncogene	Homo sapiens	45-50
8787145-1	1996	In situ reverse transcriptase-polymerase chain reaction amplification with labeled-probe hybridization (in situ RT-PCR/LPH) was used to detect measles virus RNA within formalin-fixed, paraffin-embedded brain tissue sections from a patient who died with subacute sclerosing panencephalitis (SSPE).	Formaldehyde	168-176	lactase	Homo sapiens	119-122
8788480-1	1996	In mice injected with formalin into the hindpaw, the 5-HT1A receptor agonists, 8-OH-DPAT and flesinoxan, equipotently inhibited the early phase (EP) and late phase (LP) of licking.	Formaldehyde	22-30	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	53-68
9816101-2	1996	The MIB-1 antibody detects the Ki-67 antigen in microwave-processed paraffin sections of the formalin-fixed tumors.	Formaldehyde	93-101	MIB E3 ubiquitin protein ligase 1	Homo sapiens	4-9
8932424-5	1996	In the present study the expression of PCNA was investigated in formalin-fixed, paraffin-embedded biopsy specimens of cholesteatomas and normal skin.	Formaldehyde	64-72	proliferating cell nuclear antigen	Homo sapiens	39-43
8737784-3	1996	In order to locate the mitochondrial O2- scavenging enzyme, manganese superoxide dismutase (MnSOD), the authors used a modified immunoglobulin peroxidase bridge sequence method to detect MnSOD in paraffin-embedded, formalin-fixed rat cochleas.	Formaldehyde	215-223	superoxide dismutase 2	Rattus norvegicus	60-90
8737784-3	1996	In order to locate the mitochondrial O2- scavenging enzyme, manganese superoxide dismutase (MnSOD), the authors used a modified immunoglobulin peroxidase bridge sequence method to detect MnSOD in paraffin-embedded, formalin-fixed rat cochleas.	Formaldehyde	215-223	superoxide dismutase 2	Rattus norvegicus	92-97
8832944-4	1996	OBJECTIVE AND METHODS: The aim of the present study is to examine the frequency of immunohistochemically detectable p53 protein by using two monoclonal antibodies (D07 and BP53-12) in 8 cases of formalin-fixed and paraffin-embedded specimens of verrucous skin carcinoma.	Formaldehyde	195-203	tumor protein p53	Homo sapiens	116-119
8560658-2	1996	METHODS: Immunohistochemistry of renal cell carcinoma and adjacent normal tissue was performed on formalin-fixed tissue using a specific monoclonal antibody to TGF-alpha.	Formaldehyde	98-106	transforming growth factor alpha	Homo sapiens	160-169
8778315-4	1996	Immunohistochemical staining of formalin-fixed, paraffin-embedded tissue sections after microwave antigen retrieval, using a nucleophosmin/B23-specific monoclonal antibody, showed almost exclusively diffuse nuclear reactivity of a majority of the epithelial cells in non-neoplastic mucosa: in adenomas, reactivity was almost exclusively nucleolar and in carcinomas, nuclear as well as nucleolar staining was observed.	Formaldehyde	32-40	nucleophosmin 1	Homo sapiens	125-138
8778315-4	1996	Immunohistochemical staining of formalin-fixed, paraffin-embedded tissue sections after microwave antigen retrieval, using a nucleophosmin/B23-specific monoclonal antibody, showed almost exclusively diffuse nuclear reactivity of a majority of the epithelial cells in non-neoplastic mucosa: in adenomas, reactivity was almost exclusively nucleolar and in carcinomas, nuclear as well as nucleolar staining was observed.	Formaldehyde	32-40	nucleophosmin 1	Homo sapiens	139-142
8714262-0	1996	Proliferating cell nuclear antigen (PCNA) in non-Hodgkin"s lymphomas: correlation with working formulation and Kiel classification in formalin-fixed paraffin-embedded material.	Formaldehyde	134-142	proliferating cell nuclear antigen	Homo sapiens	0-34
8714262-0	1996	Proliferating cell nuclear antigen (PCNA) in non-Hodgkin"s lymphomas: correlation with working formulation and Kiel classification in formalin-fixed paraffin-embedded material.	Formaldehyde	134-142	proliferating cell nuclear antigen	Homo sapiens	36-40
8714262-3	1996	This study documents the detection of PCNA, using antibody PC 10 in formalin-fixed, paraffin-embedded tissue, and correlates the proliferative activity of the non-Hodgkin"s lymphomas (NHL) with histological grading assessed by the International Working Formulation (WF) and Kiel classification.	Formaldehyde	68-76	proliferating cell nuclear antigen	Homo sapiens	38-42
9061378-1	1996	Several in vivo and in vitro methods for monitoring immunological properties of two allergoids obtained by formaldehyde treatment of ovalbumin (OA) were developed.	Formaldehyde	107-119	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	133-142
8570124-1	1996	The expression of pS2 estrogen-inducible protein was investigated using formalin-fixed, paraffin-embedded sections from 210 primary breast cancers.	Formaldehyde	72-80	taste 2 receptor member 64 pseudogene	Homo sapiens	18-21
9097708-2	1996	We analyzed the expression of proliferating cell nuclear antigen (PCNA) in ectocervical sections fixed in formalin and embedded in paraffin using monoclonal antibody PC10, PAP and APAAP methods.	Formaldehyde	106-114	proliferating cell nuclear antigen	Homo sapiens	30-64
9097708-2	1996	We analyzed the expression of proliferating cell nuclear antigen (PCNA) in ectocervical sections fixed in formalin and embedded in paraffin using monoclonal antibody PC10, PAP and APAAP methods.	Formaldehyde	106-114	proliferating cell nuclear antigen	Homo sapiens	66-70
7503357-2	1995	We describe here a novel microdissection technique employed to correlate HER2/neu (HER2) immunohistochemical staining with HER2 genetic analysis in formalin-fixed, paraffin-embedded breast tissue.	Formaldehyde	148-156	erb-b2 receptor tyrosine kinase 2	Homo sapiens	73-81
8526214-0	1995	Detection of bcl-1 gene rearrangement and B-cell clonality in mantle cell lymphoma using formalin-fixed, paraffin-embedded tissues.	Formaldehyde	89-97	cyclin D1	Homo sapiens	13-18
8526214-10	1995	We have demonstrated that MTC bcl-1 gene rearrangements can be amplified from formalin-fixed tissue.	Formaldehyde	78-86	cyclin D1	Homo sapiens	30-35
8526214-12	1995	With specialized nucleic acid isolation techniques and appropriate PCR protocol design, formalin-fixed, paraffin-embedded tissue is an adequate source of DNA for assessing MTC bcl-1 and IgH gene rearrangements.	Formaldehyde	88-96	cyclin D1	Homo sapiens	176-181
8526214-12	1995	With specialized nucleic acid isolation techniques and appropriate PCR protocol design, formalin-fixed, paraffin-embedded tissue is an adequate source of DNA for assessing MTC bcl-1 and IgH gene rearrangements.	Formaldehyde	88-96	immunoglobulin heavy constant delta	Homo sapiens	186-189
8550236-0	1995	E-cadherin expression in bladder cancer using formalin-fixed, paraffin-embedded tissues: correlation with histopathological grade, tumour stage and survival.	Formaldehyde	46-54	cadherin 1	Homo sapiens	0-10
8521382-6	1995	We have developed an immunohistochemical assay that allows us to assess p16 expression in formalin-fixed, paraffin-embedded tissues.	Formaldehyde	90-98	cyclin dependent kinase inhibitor 2A	Homo sapiens	72-75
7503357-2	1995	We describe here a novel microdissection technique employed to correlate HER2/neu (HER2) immunohistochemical staining with HER2 genetic analysis in formalin-fixed, paraffin-embedded breast tissue.	Formaldehyde	148-156	erb-b2 receptor tyrosine kinase 2	Homo sapiens	73-77
7503357-2	1995	We describe here a novel microdissection technique employed to correlate HER2/neu (HER2) immunohistochemical staining with HER2 genetic analysis in formalin-fixed, paraffin-embedded breast tissue.	Formaldehyde	148-156	erb-b2 receptor tyrosine kinase 2	Homo sapiens	83-87
7499099-1	1995	PURPOSE: Recent production of a monoclonal antibody, PC10, against proliferating cell nuclear antigen (PCNA) makes it possible to evaluate cell cycling in formalin-fixed tissues.	Formaldehyde	155-163	proliferating cell nuclear antigen	Homo sapiens	67-101
8719787-0	1995	Meta-chlorophenylpiperazine attenuates formalin-induced nociceptive responses through 5-HT1/2 receptors in both normal and diabetic mice.	Formaldehyde	39-47	5-hydroxytryptamine (serotonin) receptor 2A	Mus musculus	86-93
8634783-0	1995	A universal method for the mutational analysis of K-ras and p53 gene in non-small-cell lung cancer using formalin-fixed paraffin-embedded tissue.	Formaldehyde	105-113	KRAS proto-oncogene, GTPase	Homo sapiens	50-55
8634783-0	1995	A universal method for the mutational analysis of K-ras and p53 gene in non-small-cell lung cancer using formalin-fixed paraffin-embedded tissue.	Formaldehyde	105-113	tumor protein p53	Homo sapiens	60-63
8547037-4	1995	The proliferating cells were detected by immunostaining of proliferating cell nuclear antigen (PCNA) in formalin-fixed, paraffin-embedded tissue sections, using the commercially available anti-PCNA monoclonal antibody PC10.	Formaldehyde	104-112	proliferating cell nuclear antigen	Homo sapiens	95-99
7499099-1	1995	PURPOSE: Recent production of a monoclonal antibody, PC10, against proliferating cell nuclear antigen (PCNA) makes it possible to evaluate cell cycling in formalin-fixed tissues.	Formaldehyde	155-163	proliferating cell nuclear antigen	Homo sapiens	103-107
8924229-1	1995	We have performed this study to define the usefulness of an anti-human progenitor cell antigen-1(anti-CD34) to distinguish some kinds of soft tissue tumors in formalin-fixed, paraffin-embedded tissues.	Formaldehyde	159-167	CD34 molecule	Homo sapiens	102-106
8835134-1	1995	MiB-1 antibody staining can be carried out on formalin fixed, paraffin embedded tissue only if microwave antigen retrieval is performed.	Formaldehyde	46-54	MIB E3 ubiquitin protein ligase 1	Homo sapiens	0-5
7485387-7	1995	However, in formalin-fixed, paraffin-embedded tissue, discrimination of active TGF-beta by CC(1-30) was lost and immunoreactivity was distinctly extracellular, as previously reported for this antibody.	Formaldehyde	12-20	transforming growth factor beta 1	Homo sapiens	79-87
8595375-1	1995	A quantitative method of polymerase chain reaction (PCR) using both digoxigenin and radioactive labelled probes has been used for the detection of the c-erbB-2 proto-oncogene amplification in breast carcinomas with formalin-fixed paraffin-embedded tissue sections.	Formaldehyde	215-223	erb-b2 receptor tyrosine kinase 2	Homo sapiens	151-159
8640471-0	1995	Immunohistochemical detection of p53 overexpression in formalin-fixed, paraffin-embedded sections of endometrial carcinoma.	Formaldehyde	55-63	tumor protein p53	Homo sapiens	33-36
8640471-2	1995	However using CM1 and an enhanced method based on microwave heating and protease digestion enabled the immunohistochemical detection of p53 overexpression in formalin-fixed, paraffin-embedded sections of endometrial carcinoma, although very few positive stainings were obtained without such an enhanced treatment.	Formaldehyde	158-166	tumor protein p53	Homo sapiens	136-139
8732094-1	1995	Using monoclonal antibodies specific to the large intestinal mucinous antigen (LIMA), small intestinal mucinous antigen (SIMA) and CEA, the expression and localization of these proteins in 78 formalin fixed paraffin embedded tissues from ovarian epithelial tumors were studied.	Formaldehyde	192-200	CEA cell adhesion molecule 3	Homo sapiens	131-134
8747141-0	1995	Effects of local anaesthesia on formalin-induced Fos expression in the rat dorsal horn.	Formaldehyde	32-40	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	49-52
8747141-6	1995	Fos-LI was detected in the dorsal horn 2 h after the formalin injection.	Formaldehyde	53-61	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-3
8835192-1	1995	Using immunohistochemical (IH) staining for epithelial membrane antigen (EMA), keratin, Leu-7, Ca 19-9, secretory component (SC) and surfactant protein A (SPA) on formalin-fixed, paraffin-embedded autopsy cases of stillbirth and early neonatal death, the normal profile of IH-positive cells in the airway of the developing fetal lung was clarified.	Formaldehyde	163-171	surfactant protein A1	Homo sapiens	133-153
7475063-1	1995	Using anti-PCNA antibody (PC10), an immunohistochemical study of the expression of PCNA in formalin-fixed and paraffin-embedded materials of colorectal cancer patients was performed and correlation of PCNA expression with clinicopathological findings and DNA ploidy pattern was studied.	Formaldehyde	91-99	proliferating cell nuclear antigen	Homo sapiens	83-87
7560893-0	1995	Patterns of immunoreactivity to an anti-fibronectin polyclonal antibody in formalin-fixed, paraffin-embedded oral tissues are dependent on methods of antigen retrieval.	Formaldehyde	75-83	fibronectin 1	Homo sapiens	40-51
7475063-1	1995	Using anti-PCNA antibody (PC10), an immunohistochemical study of the expression of PCNA in formalin-fixed and paraffin-embedded materials of colorectal cancer patients was performed and correlation of PCNA expression with clinicopathological findings and DNA ploidy pattern was studied.	Formaldehyde	91-99	proliferating cell nuclear antigen	Homo sapiens	83-87
8570558-3	1995	Our study set out to determine whether the immunohistochemical detection of uPA in formalin-fixed, paraffin-embedded primary breast cancer tissues is of prognostic relevance.	Formaldehyde	83-91	plasminogen activator, urokinase	Homo sapiens	76-79
8732045-3	1995	RESULTS: The c-fos expression evoked by intrathecal injection (it) SP 10 micrograms and sc 5% formaldehyde (For) 150 microL in the hindpaw was densely distributed in the laminae I, II, V, and VI of spinal dorsal horn.	Formaldehyde	94-106	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	13-18
8822113-1	1995	The expression of p53 and bcl-2 was immunohistochemically investigated in 61 formalin-fixed, paraffin-embedded invasive breast carcinomas.	Formaldehyde	77-85	tumor protein p53	Homo sapiens	18-21
8593586-0	1995	7-Nitro-indazole, a selective inhibitor of neuronal nitric oxide synthase, reduces formalin evoked c-Fos expression in dorsal horn neurons of the rat spinal cord.	Formaldehyde	83-91	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	99-104
8593586-1	1995	The effect of intravenous 7-nitro-indazole (7NI), a selective inhibitor of neuronal nitric oxide synthase, on intraplantar formalin evoked spinal expression of c-Fos was studied.	Formaldehyde	123-131	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	160-165
8593586-3	1995	In contrast formalin evoked c-Fos expression in the deep laminae was reduced by 15 mg/kg of 7NI (42 +/- 8% reduction of control, P &lt; 0.05).	Formaldehyde	12-20	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	28-33
8637627-6	1995	The concentration of PACAP-like immunoreactivity in the aqueous humor was increased greatly following infrared irradiation of the iris, topical application of formaldehyde to the cornea, or intravitreal injection of endotoxin or bovine serum albumin.	Formaldehyde	159-171	LOW QUALITY PROTEIN: pituitary adenylate cyclase-activating polypeptide	Oryctolagus cuniculus	21-26
8771158-3	1995	Tumor p53 protein expression was detected by means of immunohistochemistry using the monoclonal antibody D07 on formalin fixed paraffin-embedded tissue sections.	Formaldehyde	112-120	tumor protein p53	Homo sapiens	6-9
7482737-3	1995	This study was conducted to examine the occurrence of apoptotic cell death in 44 formalin-fixed, paraffin-embedded biopsy specimens from allografted kidneys by the terminal deoxynucleiotidyl transferase (TdT)-mediated D-UTP-biotin nick end labeling (TUNEL) method.	Formaldehyde	81-89	DNA nucleotidylexotransferase	Homo sapiens	164-202
7482737-3	1995	This study was conducted to examine the occurrence of apoptotic cell death in 44 formalin-fixed, paraffin-embedded biopsy specimens from allografted kidneys by the terminal deoxynucleiotidyl transferase (TdT)-mediated D-UTP-biotin nick end labeling (TUNEL) method.	Formaldehyde	81-89	DNA nucleotidylexotransferase	Homo sapiens	204-207
7591299-4	1995	This fluorescent differential polymerase chain reaction (fd-PCR) method was used for quantificative determination of ERBB2 gene amplification in 195 formalin-fixed, paraffin-embedded breast carcinoma tissues.	Formaldehyde	149-157	erb-b2 receptor tyrosine kinase 2	Homo sapiens	117-122
7591303-2	1995	We have detected gp78 expression in buffered-formalin-fixed, paraffin-embedded sections of esophageal squamous cell carcinomas using an anti-gp78 monoclonal antibody (MAb), 3F3A, and examined the relationship between gp78 expression and clinicopathological and prognostic factors.	Formaldehyde	45-53	autocrine motility factor receptor	Homo sapiens	17-21
8654078-4	1995	Significantly higher frequencies of IL-1alpha producing cells were observed in biopsies from epoxy resin (1%) allergen-affected and formaldehyde (8%) irritant affected skin.	Formaldehyde	132-144	interleukin 1 alpha	Homo sapiens	36-45
7490678-1	1995	A rapid non-isotopic PCR-SSCP (polymerase chain reaction-single-stranded conformation polymorphism) method was developed in this study to detect polymorphism and loss of heterozygosity (LOH) of p53 in formalin-fixed and paraffin-embedded samples of normal breast tissue and of breast cancer.	Formaldehyde	201-209	tumor protein p53	Homo sapiens	194-197
8577490-1	1995	Formalin injection into the hindpaw of rats produces many neurons with c-fos protein-like immunoreactivity (fos-neurons) in the medial 3/4 of the ipsilateral dorsal horn laminae I and II at the junction of 4th and 5th lumbar segments (the sciatic territory).	Formaldehyde	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	71-76
7670110-5	1995	We developed an immunohistochemical assay to detect overexpression of the cyclin D1 protein on conventional formalin-fixed, paraffin-embedded biopsies using the well-defined monoclonal antibody DCS-6.	Formaldehyde	108-116	cyclin D1	Homo sapiens	74-83
7670110-13	1995	Detection of cyclin D1 overexpression on formalin-fixed, paraffin-embedded tissues using the DCS-6 monoclonal antibody can be applied for routine diagnostic purposes.	Formaldehyde	41-49	cyclin D1	Homo sapiens	13-22
8762479-1	1995	By using a modified polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) technique, we detected K-ras codon 12 mutation in 102 formalin-fixed, paraffin-embedded tissues from surgical samples of lung cancer patients.	Formaldehyde	158-166	KRAS proto-oncogene, GTPase	Homo sapiens	127-132
7676641-0	1995	Formaldehyde inactivation of measles virus abolishes CD46-dependent presentation of nucleoprotein to murine class I-restricted CTLs but not to class II-restricted helper T cells.	Formaldehyde	0-12	CD46 antigen, complement regulatory protein	Mus musculus	53-57
8592640-1	1995	Chemical irritation of the urinary bladder with formalin in the rat induced c-fos protein-like immunoreactivity in more than 80% of substance P receptor-like immunoreactive (SPR-LI) neurons of the dorsal commissural nucleus, sacral parasympathetic nucleus and lamina I in the 6th lumbar and 1st sacral cord segments.	Formaldehyde	48-56	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	76-81
7545663-8	1995	pH titration experiments of CaM dimethylated with [13C]formaldehyde show that Lys-75 (and Lys-148) experience a large increase in pKa upon peptide binding; this indicates an unraveling of part of the helical linker region of CaM upon cNOS peptide binding.	Formaldehyde	55-67	calmodulin 1	Rattus norvegicus	28-31
7488387-1	1995	The distribution of Bcl-2 oncoprotein was studied immunohistochemically in formaldehyde-fixed and paraffin-embedded reactive and neoplastic lymphoid tissue.	Formaldehyde	75-87	BCL2 apoptosis regulator	Homo sapiens	20-25
7653697-3	1995	METHOD: Activation of the CRH neurons was determined through measurement of the amount of CRH-mRNA in the paraventricular nucleus by using quantitative, in situ hybridization histochemistry with systematically sampled frontal sections through the hypothalamus of routinely formalin-fixed and paraffin-embedded autopsy brain material of 10 comparison subjects, 10 patients with Alzheimer"s disease, and seven depressed patients.	Formaldehyde	273-281	corticotropin releasing hormone	Homo sapiens	26-29
7490319-2	1995	METHODS: The pressure cooker antigen retrieval method was used for the immunohistochemical demonstration of EBNA-1 gene expression in formalin fixed, EBV positive tissues from Hodgkin"s disease, infectious mononucleosis, HIV associated non-Hodgkin"s lymphomas, post-transplant lymphomas, and undifferentiated nasopharyngeal carcinoma (NPC).	Formaldehyde	134-142	EBNA-1	Human gammaherpesvirus 4	108-114
7672694-4	1995	In this study we examined 88 formalin-fixed paraffin-embedded clinical specimens of cervix for the presence of HPV and p53 expression.	Formaldehyde	29-37	tumor protein p53	Homo sapiens	119-122
7672793-2	1995	We evaluated the E-CD expression in 55 cases of urinary bladder papillary transitional cell carcinoma using a double-linked immunoalkaline phosphatase procedure on formalin-fixed, paraffin-embedded specimens quantified as percentage positive staining area with the Roche RPW image analyzer (Roche Image Analysis Systems, Elon College, NC).	Formaldehyde	164-172	cadherin 1	Homo sapiens	17-21
7672800-2	1995	Formalin-fixed tissue from 50 cases of T-ALL were stained with a novel monoclonal antibody, 2TL 242, which recognizes SCL/TAL-1 protein.	Formaldehyde	0-8	TAL bHLH transcription factor 1, erythroid differentiation factor	Homo sapiens	118-127
7472782-3	1995	p53 expression was evaluated by immunohistochemistry in formalin-fixed, paraffin-embedded tissue from 23 leiomyosarcomas, 10 tumours of uncertain malignant potential (TUMPs), and 18 leiomyomas.	Formaldehyde	56-64	tumor protein p53	Homo sapiens	0-3
8532699-4	1995	The proliferative properties of the epithelium were analyzed immunohistochemically with the MIB-1 antibody, which recognizes the Ki-67 proliferation-associated nuclear antigen in formalin-fixed tissue.	Formaldehyde	179-187	MIB E3 ubiquitin protein ligase 1	Homo sapiens	92-97
8539234-1	1995	In this study, the expression of epidermal growth factor receptor (EGFr) and c-erb-B-2 was evaluated in 35 formalin-fixed, paraffin-embedded cases of transitional cell carcinomas of the urinary bladder (TCCs).	Formaldehyde	107-115	epidermal growth factor receptor	Homo sapiens	67-71
8600794-1	1995	Immunohistochemical study using the MIB 1 antibody in formalin-fixed paraffin sections.	Formaldehyde	54-62	MIB E3 ubiquitin protein ligase 1	Homo sapiens	36-41
7562249-5	1995	The proliferative activity was estimated using a Ki-67 equivalent monoclonal antibody (MIB-1), which is applicable on formalin-fixed, paraffin-embedded tissue after microwave pretreatment.	Formaldehyde	118-126	MIB E3 ubiquitin protein ligase 1	Homo sapiens	87-92
8697968-3	1995	The expression of p53 protein was also immunohistochemically studied in formalin-fixed paraffin embedded specimens of 76 colorectal adenocarcinomas and 112 colorectal polyps.	Formaldehyde	72-80	tumor protein p53	Homo sapiens	18-21
8704737-3	1995	Arginine vasopressin-containing neurons were immunohistochemically visualized in formalin-fixed tissue sections.	Formaldehyde	81-89	arginine vasopressin	Homo sapiens	9-20
8600071-0	1995	Monoclonal antibodies Ki-67 and MIB1 in the distinction of tuboendometrial metaplasia from endocervical adenocarcinoma and adenocarcinoma in situ in formalin-fixed material.	Formaldehyde	149-157	MIB E3 ubiquitin protein ligase 1	Homo sapiens	32-36
7477776-1	1995	Mutations of the p53 tumor-suppressor gene, as determined by the immunohistochemistry of archival formalin-fixed specimens, have been correlated with the prognosis for patients with many different types of malignancy.	Formaldehyde	98-106	tumor protein p53	Homo sapiens	17-20
7631152-9	1995	On the other hand, thymocytes augmented IL-6 production by TEC cells in coculture, an effect which could not be reproduced by thymocyte culture supernatant and was not inhibited by thymocyte pretreatment with formaldehyde or emetine.	Formaldehyde	209-221	tec protein tyrosine kinase	Mus musculus	59-62
9816045-7	1995	p53 gene and its protein product were examined in formalin-fixed and fresh-frozen tumor tissues using immunohistochemistry, PCR-single-strand conformational polymorphism, and sequencing.	Formaldehyde	50-58	tumor protein p53	Homo sapiens	0-3
7588444-2	1995	To enhance the detection of SP-D in formalin- or Schaffer-fixed samples, immunohistochemistry was performed by using microwave pretreatment of paraffin sections.	Formaldehyde	36-44	surfactant protein D	Rattus norvegicus	28-32
7628851-1	1995	In preliminary experiments, we found that 1H1, a monoclonal antibody directed against the v-src substrate cortactin, reacts with smooth muscle, myoepithelium, myofibroblasts, and macrophages in formaldehyde-fixed human tissues.	Formaldehyde	194-206	cortactin	Homo sapiens	106-115
8545595-3	1995	The expression of PCNA was studied by immunohistochemistry in 70 formalin-fixed, paraffin-embedded specimens of surgically removed adenocarcinomas of the gallbladder.	Formaldehyde	65-73	proliferating cell nuclear antigen	Homo sapiens	18-22
7614698-7	1995	K-ras mutations were detected by single-strand conformation analysis and identified by direct sequencing of polymerase chain reaction-amplified DNA isolated from formalin-fixed, paraffin-embedded neoplasms.	Formaldehyde	162-170	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	0-5
7674092-2	1995	The TP53 gene mutation pattern in prostatic cancer was examined in relation to progression and survival, using archival formalin-fixed pre- and post-treatment tumour specimens from 84 prostatic cancer patients.	Formaldehyde	120-128	tumor protein p53	Homo sapiens	4-8
7615970-3	1995	Unlike Ki-67 antibody, which requires frozen tissue, MIB-1 can be used on formalin-fixed tissue.	Formaldehyde	74-82	MIB E3 ubiquitin protein ligase 1	Homo sapiens	53-58
21597769-2	1995	In the present study, the expression of u-PA was immunohistochemically investigated in various thyroid tissues by using formaline-fixed, paraffin-embedded tissue sections.	Formaldehyde	120-129	plasminogen activator, urokinase	Homo sapiens	40-44
7566433-0	1995	Effects of formalin-induced pain on ACTH, beta-endorphin, corticosterone and interleukin-6 plasma levels in rats.	Formaldehyde	11-19	interleukin 6	Rattus norvegicus	77-90
7566433-5	1995	The higher formalin concentration induced stronger pain-evoked behavioral responses, paralleled by higher levels of ACTH, beta-EP and IL-6, but did not affect the other behavioral parameters.	Formaldehyde	11-19	interleukin 6	Rattus norvegicus	134-138
7781795-4	1995	To this end, the expression of EGF-R mRNA and protein by non-radioactive in-situ hybridization and immunohistochemistry, respectively, were determined on histological preparations of formalin-fixed paraffin-embedded colorectal surgical specimens.	Formaldehyde	183-191	epidermal growth factor receptor	Homo sapiens	31-36
7667207-3	1995	Using new antibodies makes it possible to evaluate the estrogen and progesterone receptor status in formalin-fixed and paraffin-embedded tissue.	Formaldehyde	100-108	progesterone receptor	Homo sapiens	68-89
7667210-5	1995	In 162 cases of primary breast cancer, pS2 was tested by immunohistochemical procedures on formalin-fixed and paraffin-embedded tissues.	Formaldehyde	91-99	taste 2 receptor member 64 pseudogene	Homo sapiens	39-42
7788840-8	1995	A significant (P &lt; 0.05) negative correlation (r = -0.65 at 5 microM, r = -0.56 at 2 microM) was obtained in the GSTT1 positive donors between DEB-induced individual SCE frequency and RBC GSTT1 activity, measured by formaldehyde formation from dichloromethane; the GSTT1 null individuals showed no GSTT1 activity.	Formaldehyde	219-231	glutathione S-transferase theta 1	Homo sapiens	116-121
7576870-1	1995	Apoptotic cells were histochemically demonstrated by the TdT-mediated biotinylated dUTP nick end-labeling (TUNEL) method in formalin-fixed and paraffin-embedded sections of the human endometrium and placental villi.	Formaldehyde	124-132	DNA nucleotidylexotransferase	Homo sapiens	57-60
7611785-2	1995	Using the avidin-biotin peroxidase complex method, the expression of c-myc protein was examined immunohistochemically for formalin-fixed paraffin embedded tissue of 51 gastric adenocarcinomas including the same cases for c-myc DNA analysis.	Formaldehyde	122-130	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	69-74
7675770-1	1995	Microwave heating of formalin-fixed, paraffin embedded tissue sections in citrate buffer (MHC) has been shown recently to enhance the antigenicity of a number of formalin-sensitive epitopes.	Formaldehyde	21-29	major histocompatibility complex, class I, C	Homo sapiens	90-93
7563978-8	1995	These results suggest that the benzodiazepine-GABAA-Cl- channel complex is involved in the mechanism underlying the delay of the development of morphine tolerance in formalin-treated mice; however, it is deduced that benzodiazepine-receptor and GABAergic systems are not always functionally coupled to each other in the mechanisms.	Formaldehyde	166-174	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	46-51
7473602-9	1995	Hexanal, formaldehyde, and malondialdehyde completely inhibited LCAT activity at 10, 50, and 50 mM, respectively.	Formaldehyde	9-21	lecithin-cholesterol acyltransferase	Homo sapiens	64-68
7675770-1	1995	Microwave heating of formalin-fixed, paraffin embedded tissue sections in citrate buffer (MHC) has been shown recently to enhance the antigenicity of a number of formalin-sensitive epitopes.	Formaldehyde	162-170	major histocompatibility complex, class I, C	Homo sapiens	90-93
7675770-8	1995	We concluded that MHC facilitates the recognition of diagnostically important antigens in formalin-fixed, paraffin-embedded tissue and can be applied routinely without adverse affects.	Formaldehyde	90-98	major histocompatibility complex, class I, C	Homo sapiens	18-21
7675778-11	1995	Nuclear cyclin D1 protein can be detected in approximately one-third of infiltrating breast carcinomas using an immunohistochemical technique on formalin-fixed, paraffin-embedded tissue.	Formaldehyde	145-153	cyclin D1	Homo sapiens	8-17
7747810-5	1995	We then attempted to correlate overexpression of cyclin D1 antigen and prognosis, by using 55 formalin-fixed, paraffin-embedded specimens of esophageal cancer.	Formaldehyde	94-102	cyclin D1	Homo sapiens	49-58
7478683-0	1995	Dextromethorphan suppresses both formalin-induced nociceptive behavior and the formalin-induced increase in spinal cord c-fos mRNA.	Formaldehyde	79-87	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	120-125
7478683-3	1995	In addition, intraplantar formalin reliably induces c-fos mRNA in the ipsilateral spinal dorsal horn as assessed with quantitative solution hybridization at 30 min postinjection.	Formaldehyde	26-34	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	52-57
7478683-5	1995	Pretreatment with dextromethorphan at 60 mg/kg s.c., 30 min prior to formalin resulted in a suppression of c-fos induction, so that c-fos mRNA levels in the ipsilateral spinal dorsal horn of animals receiving dextromethorphan prior to formalin did not differ from controls.	Formaldehyde	235-243	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	132-137
7478683-6	1995	These data indicate that dextromethorphan suppresses formalin nociceptive behavior and one of the biochemical consequences of formalin nociception, i.e., induction of c-fos mRNA.	Formaldehyde	126-134	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	167-172
7732378-1	1995	Under prebiotic conditions, formaldehyde adds to uracil at the C-5 position to produce 5-hydroxymethyluracil with favorable rates and equilibria.	Formaldehyde	28-40	complement C5	Homo sapiens	63-66
7738026-1	1995	Humans possess five classes of alcohol dehydrogenase (ADH), including forms able to oxidize ethanol or formaldehyde as part of a defense mechanism, as well as forms acting as retinol dehydrogenases in the synthesis of the regulatory ligand retinoic acid.	Formaldehyde	103-115	alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide	Homo sapiens	54-57
7600903-0	1995	Scanning microfluorometric analysis of proliferating cell nuclear antigen in formalin-fixed sections of hyperplastic and neoplastic rat liver.	Formaldehyde	77-85	proliferating cell nuclear antigen	Rattus norvegicus	39-73
7734324-4	1995	Immunohistochemical analysis of the formalin-fixed, paraffin-embedded tumours demonstrated that 7/97 (7%) had nuclear expression for MDM2 in 10-50% of the tumour cells (type 2 staining) and were denoted MDM2+.	Formaldehyde	36-44	MDM2 proto-oncogene	Homo sapiens	133-137
7645934-0	1995	Correlation of P-glycoprotein overexpression and cellular prognostic factors in formalin-fixed, paraffin-embedded tumor samples from breast cancer patients.	Formaldehyde	80-88	ATP binding cassette subfamily B member 1	Homo sapiens	15-29
7645934-2	1995	We have been able to verify this previously on fresh-frozen tumor samples, but up to now P-glycoprotein detection on formalin-fixed, paraffin-embedded material has generally been unsatisfactory.	Formaldehyde	117-125	ATP binding cassette subfamily B member 1	Homo sapiens	89-103
7671414-1	1995	Twenty cases of solar keratosis and 15 cases of Bowen"s disease were investigated for the expression of transforming growth factor alpha (TGF-alpha) by an indirect immunoperoxidase technique using monoclonal antibody TGF-alpha AB-2 in formalin-fixed wax-embedded tissue.	Formaldehyde	235-243	tumor necrosis factor	Homo sapiens	104-136
7671414-1	1995	Twenty cases of solar keratosis and 15 cases of Bowen"s disease were investigated for the expression of transforming growth factor alpha (TGF-alpha) by an indirect immunoperoxidase technique using monoclonal antibody TGF-alpha AB-2 in formalin-fixed wax-embedded tissue.	Formaldehyde	235-243	transforming growth factor alpha	Homo sapiens	138-147
7671453-6	1995	In the present study the sensitivity and specificity of the widely used antiserum against PGP 9.5 has been retrospectively examined on 290 formalin-fixed, paraffin-embedded tumors of the nervous system and small round blue cell tumors.	Formaldehyde	139-147	ubiquitin C-terminal hydrolase L1	Homo sapiens	90-97
7607382-4	1995	Studies with immunohistochemical analyses of EGF-R overexpression in formalin-fixed, paraffin-embedded tumour samples are rare.	Formaldehyde	69-77	epidermal growth factor receptor	Homo sapiens	45-50
7607382-5	1995	In a retrospective study, we examined the clinical data from 142 patients and the EGF-R expression in their formalin-fixed, paraffin-embedded tumour samples.	Formaldehyde	108-116	epidermal growth factor receptor	Homo sapiens	82-87
7607382-12	1995	In this study, the determination of EGF-R in formalin-fixed, paraffin-embedded tumour samples proved feasible.	Formaldehyde	45-53	epidermal growth factor receptor	Homo sapiens	36-41
7751909-6	1995	Inhibitors of PKC (GF 109203X, chelerythrine), produced significant reductions of nociceptive responses to 2.5% formalin, as well as a significant reduction in the mechanical hyperalgesia in the hindpaw contralateral to a thermal injury.	Formaldehyde	112-120	protein kinase C, gamma	Rattus norvegicus	14-17
7759657-7	1995	Analysis of data obtained from formalin fixed bovine Achilles tendon and human myocardium yield estimated values for c13 of 3.17 and 2.46 GPa, respectively.	Formaldehyde	31-39	homeobox C13	Homo sapiens	117-120
7593754-1	1995	This report describes the immunohistochemical detection of von Willebrand"s factor (vWf) and CD31 antigen in paraffin wax-embedded, formalin-fixed tissue sections of canine normal organs and vascular neoplasms.	Formaldehyde	132-140	von Willebrand factor	Canis lupus familiaris	59-82
7629289-2	1995	METHODS: Two monoclonal antibodies, MIB-1 and oestrogen receptor, were applied to formalin fixed, paraffin wax embedded tissue from 25 prospectively collected oestrogen receptor positive breast carcinomas, using a microwave antigen retrieval method.	Formaldehyde	82-90	MIB E3 ubiquitin protein ligase 1	Homo sapiens	36-64
7783370-3	1995	The results of several fixation methods demonstrated that formalin and methanol, formalin and ethanol (1:9) and buffered formalin acetone gave good results for detecting p53 protein.	Formaldehyde	58-66	tumor protein p53	Homo sapiens	170-173
7751909-1	1995	We have previously suggested that protein kinase C (PKC) contributes to persistent pain in the formalin test.	Formaldehyde	95-103	protein kinase C, gamma	Rattus norvegicus	34-50
7751909-1	1995	We have previously suggested that protein kinase C (PKC) contributes to persistent pain in the formalin test.	Formaldehyde	95-103	protein kinase C, gamma	Rattus norvegicus	52-55
7700181-2	1995	Formalin-fixed, paraffin-embedded tissue specimens of 24 primary neuroblastomas were immunostained using an anti-PCNA monoclonal antibody and the PCNA index was calculated.	Formaldehyde	0-8	proliferating cell nuclear antigen	Homo sapiens	146-150
7715901-2	1995	EGFR gene amplification was examined by slot-blot hybridization using DNA extracted from formalin-fixed, paraffin-embedded tissues.	Formaldehyde	89-97	epidermal growth factor receptor	Homo sapiens	0-4
7751909-5	1995	Changes in the levels of membrane-associated PKC, as assayed by quantitative autoradiography of the specific binding of 3H-phorbol-12,13-dibutyrate (3H-PDBu) in spinal cord sections, were assessed in rats after noxious chemical (50 microliters of 5.0% formalin) and noxious thermal (90 sec immersion in water at 55 degrees C) stimulation.	Formaldehyde	252-260	protein kinase C, gamma	Rattus norvegicus	45-48
7751909-8	1995	The results provide both pharmacological and anatomical evidence that persistent pain produced by chemical stimulation with formalin and mechanical hyperalgesia in the hindpaw contralateral to a thermal injury are influenced by the translocation and activation of PKC in spinal cord dorsal horn neurons.	Formaldehyde	124-132	protein kinase C, gamma	Rattus norvegicus	264-267
7659444-3	1995	In mice, the NK1 antagonist, CP 99,994, preferentially (inhibitory dose50 (ID50) = 4.4) inhibited the late phase (LP) as compared to the early phase (EP) (16.1) of formalin-induced licking (FIL).	Formaldehyde	164-172	tachykinin 1	Mus musculus	13-16
7783370-3	1995	The results of several fixation methods demonstrated that formalin and methanol, formalin and ethanol (1:9) and buffered formalin acetone gave good results for detecting p53 protein.	Formaldehyde	81-89	tumor protein p53	Homo sapiens	170-173
7747282-0	1995	Immunohistochemical localization of p53, PCNA, and TGF-alpha proteins in formaldehyde-induced rat nasal squamous cell carcinomas.	Formaldehyde	73-85	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	36-39
7620882-2	1995	The distribution of c-fos-positive cells was dense in the superficial laminae and sparse in the deep laminae of the MDH and C1 in both young and aged animals following subcutaneous injection of formalin into the lateral face, whereas few c-fos-positive cells were labeled after saline injection.	Formaldehyde	194-202	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	20-25
7747282-0	1995	Immunohistochemical localization of p53, PCNA, and TGF-alpha proteins in formaldehyde-induced rat nasal squamous cell carcinomas.	Formaldehyde	73-85	transforming growth factor alpha	Rattus norvegicus	51-60
7747282-2	1995	Alterations in the p53 gene have also been identified in certain rodent tumors, including formaldehyde-induced nasal squamous cell carcinomas.	Formaldehyde	90-102	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	19-22
7747282-3	1995	Overexpression of transforming growth factor-alpha (TGF-alpha) is associated with carcinomas of the head and neck and respiratory tract in human patients and formaldehyde-induced rat nasal squamous cell carcinomas.	Formaldehyde	158-170	tumor necrosis factor	Homo sapiens	18-50
7747282-3	1995	Overexpression of transforming growth factor-alpha (TGF-alpha) is associated with carcinomas of the head and neck and respiratory tract in human patients and formaldehyde-induced rat nasal squamous cell carcinomas.	Formaldehyde	158-170	transforming growth factor alpha	Homo sapiens	52-61
7747282-9	1995	Mutation of the p53 tumor suppressor gene may be an important step in the progression of formaldehyde-induced nasal carcinogenesis in the rat.	Formaldehyde	89-101	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	16-19
7624039-1	1995	In rats which were injected with horseradish peroxidase (HRP) into the midbrain periaqueductal gray (PAG) and then administered with formaldehyde into the stomach, Fos-like immunoreactivity was found in tyrosine hydroxylase-like immunoreactive neurons in the nucleus tractus solitarii (NTS) which were retrogradely labeled with HRP.	Formaldehyde	133-145	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	164-167
7890376-5	1995	In contrast, whole cells of formaldehyde-treated P. granulosum and S. epidermidis significantly stimulated release of IL-1 beta by PBMCs from three donors compared with the negative control (culture medium).	Formaldehyde	28-40	interleukin 1 alpha	Homo sapiens	118-122
7547494-1	1995	Expression of c-erbB-2 and p53 protein was analysed retrospectively by immunohistochemistry in formalin-fixed tissue samples from 293 patients with colorectal adenocarcinoma.	Formaldehyde	95-103	erb-b2 receptor tyrosine kinase 2	Homo sapiens	14-22
7547494-1	1995	Expression of c-erbB-2 and p53 protein was analysed retrospectively by immunohistochemistry in formalin-fixed tissue samples from 293 patients with colorectal adenocarcinoma.	Formaldehyde	95-103	tumor protein p53	Homo sapiens	27-30
7620617-0	1995	BDNF produces analgesia in the formalin test and modifies neuropeptide levels in rat brain and spinal cord areas associated with nociception.	Formaldehyde	31-39	brain-derived neurotrophic factor	Rattus norvegicus	0-4
7620617-2	1995	BDNF administration attenuated the behavioural response in the tail-flick and hot-plate tests, two models employing a phasic, thermal high-intensity nociceptive stimulus; the present studies extend our previous findings to include a model of moderate, continuous pain resulting from a chemical stimulus, the formalin test.	Formaldehyde	308-316	brain-derived neurotrophic factor	Rattus norvegicus	0-4
7620617-3	1995	Midbrain infusion of BDNF decreased the behavioural paw flinch response to subcutaneous formalin injection in both the early and late phases of the test.	Formaldehyde	88-96	brain-derived neurotrophic factor	Rattus norvegicus	21-25
7726729-0	1995	A microwave method that enhances detection of aberrant p53 expression in formalin-fixed, paraffin-embedded tissues.	Formaldehyde	73-81	tumor protein p53	Homo sapiens	55-58
7726729-10	1995	CONCLUSIONS: Microwave pretreatment in conjunction with the use of either PAb1801 or DO7 is highly efficacious in the immunohistochemical detection of aberrant p53 expression in formalin-fixed, paraffin-embedded tissues.	Formaldehyde	178-186	tumor protein p53	Homo sapiens	160-163
7719158-1	1995	The effect of formaldehyde exposure on the sensitization of mice to ovalbumin was investigated.	Formaldehyde	14-26	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	68-77
7719158-2	1995	Significantly increased IgE antiovalbumin titers were found in mice sensitized intranasally to ovalbumin and exposed for 10 days to 2 mg/m3 of formaldehyde.	Formaldehyde	143-155	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	32-41
7719158-4	1995	The exposure of mice, sensitized intraperitoneally with ovalbumin, to formaldehyde did not increase sensitization.	Formaldehyde	70-82	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	56-65
7719158-5	1995	It was concluded that formaldehyde facilitates sensitization of mice to ovalbumin by changes that occur in the respiratory tract.	Formaldehyde	22-34	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	72-81
7620336-1	1995	Immunohistochemical analysis of the N-ras p21 and the p53 proteins was carried out on formalin-fixed sections of naevi, primary melanomas and metastases from patients with sporadic melanoma (SCMM) and with hereditary melanoma (HCMM)/dysplastic naevus syndrome (DNS).	Formaldehyde	86-94	NRAS proto-oncogene, GTPase	Homo sapiens	36-41
7882282-5	1995	METHODS: Immunohistochemical staining for HER was performed on 10% formalin fixed paraffin embedded primary carcinomas from 440 patients with negative axillary lymph nodes with a median follow-up of 119 months.	Formaldehyde	67-75	erb-b2 receptor tyrosine kinase 2	Homo sapiens	42-45
7542384-4	1995	Hence, B23 was detectable in all stromal as well as in normal and malignant epithelial prostatic cells, both in fresh and in formalin-fixed tissue sections after microwave treatment.	Formaldehyde	125-133	nucleophosmin 1	Homo sapiens	7-10
7612496-3	1995	PATIENTS AND METHODS: To assess the utility of in situ hybridization (ISH) to detect cyclin D1 mRNA expression in formalin-fixed, paraffin embedded tissue, five MCL specimens from three patients and two cases of B-cell small lymphocytic lymphoma (B-SLL) were studied.	Formaldehyde	114-122	cyclin D1	Homo sapiens	85-94
7534025-3	1995	The expression of CA-125, epithelial membrane antigen (EMA) and vimentin by malignant epithelial mesothelioma cells was hindered by their poor preservation in formalin fixative.	Formaldehyde	159-167	mucin 16, cell surface associated	Homo sapiens	18-24
7534025-3	1995	The expression of CA-125, epithelial membrane antigen (EMA) and vimentin by malignant epithelial mesothelioma cells was hindered by their poor preservation in formalin fixative.	Formaldehyde	159-167	vimentin	Homo sapiens	64-72
7612496-9	1995	CONCLUSIONS: Overexpression of cyclin D1 mRNA can be detected in MCL by ISH using formalin fixed paraffin embedded tissue.	Formaldehyde	82-90	cyclin D1	Homo sapiens	31-40
7850711-2	1995	BACKGROUND: MIB-1 was found to be detectable in formalin fixed, paraffin embedded materials with microwave treatment using Ki-67 monoclonal antibody, and immunostaining has been widely documented as a useful marker of proliferation.	Formaldehyde	48-56	MIB E3 ubiquitin protein ligase 1	Homo sapiens	12-17
7887887-2	1995	We observed the presence of a mutated beta-MHC mRNA in a formalin-fixed paraffin-embedded myocardial tissue of a proband from family A, which Geisterfer-Lowrance et al.	Formaldehyde	57-65	major histocompatibility complex, class I, C	Homo sapiens	43-46
7774494-2	1995	To this effect, we compared the expression of neu oncoprotein in formalin-fixed paraffin-embedded breast cancers and the corresponding fine-needle aspirates of these cancers.	Formaldehyde	65-73	erb-b2 receptor tyrosine kinase 2	Homo sapiens	46-49
7867006-2	1995	Overexpression of cyclin D1 was detected immunohistochemically using an affinity-purified polyclonal antibody directed against the carboxyl-terminal part of the cyclin D1 protein, applied to formalin-fixed, paraffin-embedded tissue sections.	Formaldehyde	191-199	cyclin D1	Homo sapiens	18-27
7867006-2	1995	Overexpression of cyclin D1 was detected immunohistochemically using an affinity-purified polyclonal antibody directed against the carboxyl-terminal part of the cyclin D1 protein, applied to formalin-fixed, paraffin-embedded tissue sections.	Formaldehyde	191-199	cyclin D1	Homo sapiens	161-170
7735554-3	1995	Polymerase chain reaction (PCR) amplification of formalin-fixed paraffin-embedded tissue showed differences in the clonality of each separate lymphoproliferative lesion examined, as determined by immunoglobulin heavy chain (IgH) gene rearrangement.	Formaldehyde	49-57	immunoglobulin heavy constant delta	Homo sapiens	196-222
7735554-3	1995	Polymerase chain reaction (PCR) amplification of formalin-fixed paraffin-embedded tissue showed differences in the clonality of each separate lymphoproliferative lesion examined, as determined by immunoglobulin heavy chain (IgH) gene rearrangement.	Formaldehyde	49-57	immunoglobulin heavy constant delta	Homo sapiens	224-227
7548788-5	1995	The aim of this study was to detect and localize the immunohistochemical expression of P-gp in normal and neoplastic gastrointestinal tissue using the Mab JSB-1 in formalin-fixed paraffin-embedded specimens.	Formaldehyde	164-172	phosphoglycolate phosphatase	Homo sapiens	87-91
7890280-0	1995	A new immunohistochemical antibody for the assessment of estrogen receptor status on routine formalin-fixed tissue samples.	Formaldehyde	93-101	estrogen receptor 1	Homo sapiens	57-74
7890280-1	1995	We describe a method for the immunocytochemical assessment of estrogen receptor (ER) status on routinely processed, formalin-fixed tissue using a recently developed commercially available monoclonal antibody (Dako 1D5) with a microwave antigen retrieval technique.	Formaldehyde	116-124	estrogen receptor 1	Homo sapiens	62-79
7777163-0	1995	c-fos antisense oligodeoxynucleotide increases formalin-induced nociception and regulates preprodynorphin expression.	Formaldehyde	47-55	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-5
7890280-1	1995	We describe a method for the immunocytochemical assessment of estrogen receptor (ER) status on routinely processed, formalin-fixed tissue using a recently developed commercially available monoclonal antibody (Dako 1D5) with a microwave antigen retrieval technique.	Formaldehyde	116-124	estrogen receptor 1	Homo sapiens	81-83
7890280-6	1995	We conclude that assessment of ER status using this new antibody and technique gives accurate results on routinely processed, formalin-fixed tissue and may be used as an alternative to other methods.	Formaldehyde	126-134	estrogen receptor 1	Homo sapiens	31-33
7538162-1	1995	A reverse transcriptase nested polymerase reaction (RT-nPCR) method has been developed to detect the presence of a tumour-specific translocation in archival formalin-fixed, paraffin-embedded tissue.	Formaldehyde	157-165	nasopharyngeal carcinoma-related protein	Homo sapiens	55-59
7567689-1	1995	An antibody to the ret proto-oncogene product (RET) was raised and applied to formalin-fixed, paraffin-embedded neuroblastic tumors (NBTs) to investigate its usefulness in diagnosis and evaluation of cell differentiation.	Formaldehyde	78-86	ret proto-oncogene	Homo sapiens	19-22
7567689-1	1995	An antibody to the ret proto-oncogene product (RET) was raised and applied to formalin-fixed, paraffin-embedded neuroblastic tumors (NBTs) to investigate its usefulness in diagnosis and evaluation of cell differentiation.	Formaldehyde	78-86	ret proto-oncogene	Homo sapiens	47-50
7596621-4	1995	The expression of the Fos protein was related to the intensity of stimulation since greater injection volumes of formalin or prolonged application of the thermal stimulus increased the number of stained nuclei.	Formaldehyde	113-121	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	22-25
7777163-4	1995	These observations could be interpreted as representing a sequence of events beginning with the formalin-induced increase in the transcription factor Fos, which in turn increases the synthesis of preprodynorphin messenger RNA resulting in the production of the dynorphin opioid peptides which then exert a modulatory antinociceptive action.	Formaldehyde	96-104	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	150-153
7777163-4	1995	These observations could be interpreted as representing a sequence of events beginning with the formalin-induced increase in the transcription factor Fos, which in turn increases the synthesis of preprodynorphin messenger RNA resulting in the production of the dynorphin opioid peptides which then exert a modulatory antinociceptive action.	Formaldehyde	96-104	prodynorphin	Rattus norvegicus	196-211
7766265-3	1995	We studied cellular proliferation in 53 breast carcinomas using quantitative image analysis of immunoreactivity to a recently available monoclonal antibody, MIB-1, which is applicable to formalin-fixed, paraffin-embedded tissues.	Formaldehyde	187-195	MIB E3 ubiquitin protein ligase 1	Homo sapiens	157-162
7695015-4	1995	In this study, we analyzed bcl-2 protein expression in cutaneous malignant melanoma (MM) (29 cases) and benign melanocytic nevi (BMN) (35 cases) using a high specific anti-bcl-2 monoclonal antibody with a standard three-step immunoperoxidase technique on formalin-fixed, paraffin-embedded tissue sections.	Formaldehyde	255-263	BCL2 apoptosis regulator	Homo sapiens	27-32
7856554-2	1995	The aim of this study is to investigate whether hepatitis B e antigen (HBeAg) reactivity can be detected on formalin-fixed, paraffin-embedded liver tissue, and whether immunohistochemical detection of intrahepatic HBeAg may help to distinguish between "wild-type" and "eminus" hepatitis B virus (HBV) infection.	Formaldehyde	108-116	capsid protein;pre-capsid protein	Hepatitis B virus	48-77
7856554-8	1995	These results show that HBeAg can be detected in formalin-fixed, paraffin-embedded liver specimens, and the method is sensitive and specific.	Formaldehyde	49-57	capsid protein;pre-capsid protein	Hepatitis B virus	24-29
7531794-5	1995	EXPERIMENTAL DESIGN: We used nucleic acid in situ hybridization to detect bFGF-specific mRNA transcripts within MCs in formalin-fixed, paraffin-embedded specimens of nonlesional human skin and skin containing increased numbers of MCs, including granulation tissues, benign cutaneous mastocytosis, and solitary neurofibromas.	Formaldehyde	119-127	fibroblast growth factor 2	Homo sapiens	74-78
7883227-2	1995	In situ hybridisation analysis of formalin fixed, routinely processed biopsy specimens was used to localise CYP3A mRNA in human gastrointestinal tissues from several individuals.	Formaldehyde	34-42	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	108-113
7556591-6	1995	Nuclear p53 immunoreactivity was assessed using a monoclonal antibody, DO-1, on Formalin-fixed paraffin-embedded specimens.	Formaldehyde	80-88	tumor protein p53	Homo sapiens	8-11
7742922-0	1995	Antigen retrieval for bcl-2 protein in formalin-fixed, paraffin-embedded sections.	Formaldehyde	39-47	BCL2 apoptosis regulator	Homo sapiens	22-27
7536308-9	1995	Both morphine and naltrexone blocked the formalin-induced increases in neurokinin B and neurokinin-3 receptor messenger RNA levels.	Formaldehyde	41-49	tachykinin precursor 3	Rattus norvegicus	71-83
7540280-0	1995	The neurokinin-1 receptor antagonist, sendide, exhibits antinociceptive activity in the formalin test.	Formaldehyde	88-96	tachykinin 1	Mus musculus	4-16
7540280-8	1995	The results indicate that the antinociceptive effects of sendide and [D-Trp7]sendide may be mediated at NK1 receptors in the formalin-induced nociception.	Formaldehyde	125-133	transient receptor potential cation channel, subfamily C, member 7	Mus musculus	72-76
7777480-1	1995	Proliferating cell nuclear antigen (PCNA), an auxiliary protein of DNA polymerase-delta, has recently been proposed as a marker of proliferation that is detectable in formalin-fixed paraffin-embedded tissue.	Formaldehyde	167-175	proliferating cell nuclear antigen	Homo sapiens	0-34
7777480-1	1995	Proliferating cell nuclear antigen (PCNA), an auxiliary protein of DNA polymerase-delta, has recently been proposed as a marker of proliferation that is detectable in formalin-fixed paraffin-embedded tissue.	Formaldehyde	167-175	proliferating cell nuclear antigen	Homo sapiens	36-40
7777480-1	1995	Proliferating cell nuclear antigen (PCNA), an auxiliary protein of DNA polymerase-delta, has recently been proposed as a marker of proliferation that is detectable in formalin-fixed paraffin-embedded tissue.	Formaldehyde	167-175	DNA polymerase delta 1, catalytic subunit	Homo sapiens	67-87
7777480-3	1995	In this study, we investigate the relationship between formalin fixation time and immunoreactivity for PCNA in paraffin-embedded sections and examine the effect of postfixation tissue treatment with modified Bouin"s solution.	Formaldehyde	55-63	proliferating cell nuclear antigen	Homo sapiens	103-107
7777480-10	1995	Fixation-time dependence of PCNA immunoreactivity has immediate implications for intra- and interlaboratory comparisons, especially in experimental studies in which specimens can be stored in formalin for variable times followed by batch processing.	Formaldehyde	192-200	proliferating cell nuclear antigen	Homo sapiens	28-32
7540280-8	1995	The results indicate that the antinociceptive effects of sendide and [D-Trp7]sendide may be mediated at NK1 receptors in the formalin-induced nociception.	Formaldehyde	125-133	tachykinin 1	Mus musculus	104-107
7742922-2	1995	In order to overcome the difficulty in identifying bcl-2 protein in formalin-fixed, paraffin-embedded sections, its antigenicity was retrieved by a variety of pretreatments.	Formaldehyde	68-76	BCL2 apoptosis regulator	Homo sapiens	51-56
7784901-2	1995	It was found that a dose-dependent increase of Fos-like immunoreactive neurons could be induced by M3G intrathecal injection followed by formaline injection into hindpaw.	Formaldehyde	137-146	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	47-50
7737308-0	1995	A selective CCKB receptor antagonist potentiates, mu-, but not delta-opioid receptor-mediated antinociception in the formalin test.	Formaldehyde	117-125	cholecystokinin B receptor	Mus musculus	12-25
7737308-10	1995	Therefore, in the formalin test with mice, the facilitating effects of opiate-induced analgesia by CCKB receptor antagonists seem to be restricted to mu-opioid receptor-mediated responses.	Formaldehyde	18-26	cholecystokinin B receptor	Mus musculus	99-112
7813113-6	1995	Formalin-killed or live L. pneumophila-stimulated PBL expressed the mRNA for IFN-gamma but not the mRNA for IL-4.	Formaldehyde	0-8	interferon gamma	Homo sapiens	77-86
7618442-1	1995	The hippocampal distribution of mRNA for the N-methyl-D-aspartate (NMDA) receptor subunit 1 (NR1) was examined by non-radioactive in situ hybridization in 21 archival formalin-fixed and paraffin-embedded surgical specimens from patients with pharmacoresistant chronic epilepsy and in normal control specimens obtained at autopsy.	Formaldehyde	167-175	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	45-96
8748587-4	1995	We then examined the expression of Fos protein in CNS induced by formalin injection into the face in cats.	Formaldehyde	65-73	Fos proto-oncogene, AP-1 transcription factor subunit	Felis catus	35-38
8748587-5	1995	Fos positive neurons were demonstrated in areas 23 and 24, the anterior limbic area, insular cortex, midline and paraventricular nuclei in the thalamus, paraventricular nucleus and other areas in the hypothalamus, and in many nuclei in the brainstem in both the formalin-injected group and the control group (anesthesia only).	Formaldehyde	262-270	Fos proto-oncogene, AP-1 transcription factor subunit	Felis catus	0-3
7825569-3	1995	The mean (+/- SD) specific MTHFR activity in lymphocytes of 22 control subjects was 15.6 (+/- 4.7) nmol CH2O/mg protein/h (range: 9.1-26.6), and the residual activity (+/- SD) after heat inactivation for 5 min at 46 degrees C was 55.3 (+/- 12.0)% (range: 35.9-78.3).	Formaldehyde	104-108	methylenetetrahydrofolate reductase	Homo sapiens	27-32
7825569-5	1995	One group (n = 11) had thermolabile MTHFR with a mean (+/- SD) specific activity of 8.7 (+/- 2.1) nmol CH2O/mg protein/h (range: 5.5-12.7) and a residual activity, after heat inactivation, ranging from 0% to 33%.	Formaldehyde	103-107	methylenetetrahydrofolate reductase	Homo sapiens	36-41
7579511-1	1995	Immunostaining for heat-shock protein-27 (HSP-27) was performed on formalin fixed-paraffin embedded sections of 890 node-positive breast carcinomas resected between 1980 and 1986.	Formaldehyde	67-75	heat shock protein family B (small) member 1	Homo sapiens	42-48
7813113-10	1995	A significant correlation between the proliferative response to formalin-killed L. pneumophila and IFN-gamma release in culture was observed (r = 0.6932, P &lt; 0.001) in PBL from 30 healthy volunteers.	Formaldehyde	64-72	interferon gamma	Homo sapiens	99-108
7890301-12	1995	Confirming these data, presentation by formaldehyde-fixed cells of C3b-TT proteolysates showed higher stimulation of specific T-cell clones than formaldehyde-fixed TT proteolysates.	Formaldehyde	39-51	complement C3	Homo sapiens	67-70
7821917-1	1995	An immunohistochemical study of 15 ovarian formalin-fixed, paraffin-embedded dysgerminomas showed positive staining of tumor cells for vimentin in all cases.	Formaldehyde	43-51	vimentin	Homo sapiens	135-143
8536762-1	1995	The expression of PCNA was examined by immunohistochemistry on 95 formalin-fixed breast surgical specimens.	Formaldehyde	66-74	proliferating cell nuclear antigen	Homo sapiens	18-22
8907637-0	1995	Improved detection of CD2 on formaldehyde-fixed non dehydrated cells.	Formaldehyde	29-41	CD2 molecule	Homo sapiens	22-25
8002620-1	1995	Methanol dehydrogenase, the enzyme that oxidizes methanol to formaldehyde in gram-negative methylotrophs, contains the prosthetic group pyrroloquinoline quinone (PQQ).	Formaldehyde	61-73	MEXAM1_RS09450	Methylobacterium extorquens AM1	0-22
7822763-3	1995	Biopsy specimens (n = 64) of 12 different dermatoses were therefore screened with an MxA-specific monoclonal antibody on formalin-fixed, paraffin-embedded and microwave-treated tissue sections.	Formaldehyde	121-129	MX dynamin like GTPase 1	Homo sapiens	85-88
9053548-5	1995	It is emphasized that immunolabelling for catalase in formalin-fixed archival liver samples and in liver autopsy tissue (in the latter also for the peroxisomal beta-oxidation enzymes) permits visualization of peroxisomes; this can be helpful in diagnosing an index case retrospectively.	Formaldehyde	54-62	catalase	Homo sapiens	42-50
21597698-1	1995	Overexpression of PCNA (more than 25% positive tumour cells) and positivity of c-erbB-2 oncoprotein were immunohistochemically demonstrated in 490 formalin-fixed and paraffin-embedded breast carcinomas.	Formaldehyde	147-155	proliferating cell nuclear antigen	Homo sapiens	18-22
7562003-1	1995	In an effort to optimize immunocytochemical methods to evaluate cell kinetics in brain tumors, we studied two newly-developed antibodies which react with formalin resistant epitopes of Proliferating Cellular Nuclear Antigen (PCNA) and Ki-67.	Formaldehyde	154-162	proliferating cell nuclear antigen	Homo sapiens	185-223
7562003-1	1995	In an effort to optimize immunocytochemical methods to evaluate cell kinetics in brain tumors, we studied two newly-developed antibodies which react with formalin resistant epitopes of Proliferating Cellular Nuclear Antigen (PCNA) and Ki-67.	Formaldehyde	154-162	proliferating cell nuclear antigen	Homo sapiens	225-229
8592170-2	1995	Expression of NCAM in human pituitary adenomas was assessed on snap-frozen and Bouin"s and/or formalin-fixed, paraffin-embedded archival tissue using a sensitive alkaline phosphatase-antialkaline phosphatase method of immunostaining with the monoclonal antibody, NKH-1.	Formaldehyde	94-102	neural cell adhesion molecule 1	Homo sapiens	14-18
7704245-1	1995	The expression of p53 protein was studied in formalin-fixed paraffin-embedded specimens of 41 well-differentiated adenocarcinomas of the gall-bladder, six cases of acute cholecystitis and 23 cases of chronic cholecystitis, using a monoclonal p53 (PAb 1801) antibody and streptavidin-biotin.	Formaldehyde	45-53	tumor protein p53	Homo sapiens	18-21
21597698-1	1995	Overexpression of PCNA (more than 25% positive tumour cells) and positivity of c-erbB-2 oncoprotein were immunohistochemically demonstrated in 490 formalin-fixed and paraffin-embedded breast carcinomas.	Formaldehyde	147-155	erb-b2 receptor tyrosine kinase 2	Homo sapiens	79-87
8584666-4	1995	Recent evidence has accumulated that SSAO may also be involved in metabolizing endogenous aliphatic amines such as methylamine and aminoacetone, focussing attention on the fact that the aldehyde products (formaldehyde and methylglyoxal, respectively) are potentially cytotoxic agents.	Formaldehyde	205-217	amine oxidase copper containing 2	Homo sapiens	37-41
7780691-2	1995	Cathepsin D expression was determined by immunohistochemistry in 445 formalin fixed, paraffin embedded primary invasive breast carcinomas.	Formaldehyde	69-77	cathepsin D	Homo sapiens	0-11
8584667-5	1995	The possibility that SSAO enzymes can convert amine substrates to highly toxic metabolites is illustrated by the production of acrolein from the xenobiotic amine, allylamine and formaldehyde and methylglyoxal from methylamine and aminoacetone, respectively.	Formaldehyde	178-190	amine oxidase copper containing 2	Homo sapiens	21-25
8916346-0	1995	c-fos expression after formalin injection into the face in the cat.	Formaldehyde	23-31	Fos proto-oncogene, AP-1 transcription factor subunit	Felis catus	0-5
8916346-1	1995	Expression of the c-fos gene in CNS induced by formalin injection into the face as pain stimulus was examined in cats.	Formaldehyde	47-55	Fos proto-oncogene, AP-1 transcription factor subunit	Felis catus	18-23
7640465-1	1995	Immunostaining of the proliferating cell nuclear antigen (PCNA) provides important information about cell kinetics and is easily performed on routinely obtained formalin-fixed, paraffin-embedded materials.	Formaldehyde	161-169	proliferating cell nuclear antigen	Homo sapiens	22-56
8916346-2	1995	Fos-positive neurons were demonstrated in the anterior cingulate, anterior insula and other areas of the cerebral cortex bilaterally, midline thalamic nuclei, hypothalamus, and brainstem in both the formalin-injected and control group (anesthesia only).	Formaldehyde	199-207	Fos proto-oncogene, AP-1 transcription factor subunit	Felis catus	0-3
7640465-1	1995	Immunostaining of the proliferating cell nuclear antigen (PCNA) provides important information about cell kinetics and is easily performed on routinely obtained formalin-fixed, paraffin-embedded materials.	Formaldehyde	161-169	proliferating cell nuclear antigen	Homo sapiens	58-62
7725609-0	1995	Assessment of proliferative activity by anti-PCNA monoclonal antibodies in formalin-fixed, paraffin-embedded samples and correlation with mitotic index.	Formaldehyde	75-83	proliferating cell nuclear antigen	Homo sapiens	45-49
7633653-4	1995	MIB-1 immunohistochemistry is used instead of Ki-67 immunohistochemistry if a tumour is delivered to the pathologist after formalin fixation or if that part of the tissue suspicious for breast cancer must be totally embedded in order to confirm the diagnosis.	Formaldehyde	123-131	MIB E3 ubiquitin protein ligase 1	Homo sapiens	0-5
7533548-8	1994	The technique was useful in demonstrating the soluble formalin-sensitive antigen p19 on cytospins fixed in formaldehyde vapour.	Formaldehyde	54-62	interleukin 23 subunit alpha	Homo sapiens	81-84
7987854-2	1994	We have investigated the localization of uPA and PAI-1 immunohistochemically in formalin-fixed paraffin-embedded tissue sections.	Formaldehyde	80-88	plasminogen activator, urokinase	Homo sapiens	41-44
7527069-1	1994	Monoclonal antibodies were generated against the feline homologue of CD4 (fCD4) by immunisation of mice with solid matrix antigen-antibody complexes of monoclonal antibody Fel7 (anti-fCD4) and formalin-fixed Staphylococcus A (SMAA-fCD4).	Formaldehyde	193-201	CD4 antigen	Mus musculus	69-72
7536376-8	1994	Pre-heating formaldehyde-fixed sections from cattle, rabbit and rat brain in a microwave oven prior to the immunohistochemical reaction resulted in an enormous enhancement of vimentin staining of mesoderm-derived tissues, of astrocytes and bergmann cell fibers.	Formaldehyde	12-24	vimentin	Rattus norvegicus	175-183
8578818-12	1995	These results demonstrate that DL-PLG microspheres containing formalin-fixed, inactivated VEE virus were effective in augmenting circulating IgG antibody levels and neutralization titers to the VEE virus following systemic immunization and in affording enhanced protection against systemic challenge with virulent VEE virus.	Formaldehyde	62-70	plasminogen	Homo sapiens	34-37
8600679-3	1995	We have evaluated the expression of CD44 standard (CD44s) and variant exons (CD44v) encoded gene products in formalin-fixed and paraffin-embedded human liver specimens, using an immunohistochemical protocol with microwave-based antigen-retrieval and signal amplification.	Formaldehyde	109-117	CD44 molecule (Indian blood group)	Homo sapiens	36-40
7533548-8	1994	The technique was useful in demonstrating the soluble formalin-sensitive antigen p19 on cytospins fixed in formaldehyde vapour.	Formaldehyde	107-119	interleukin 23 subunit alpha	Homo sapiens	81-84
7531681-1	1994	Immunohistochemical expression of PRAD1/cyclin D1 protein has been investigated in 106 tissue specimens of 104 cases of lymphoma, non-neoplastic lymphoid disorders and other hematologic malignancies by employing the monoclonal antibody 5D4 with formalin-fixed paraffin-embedded sections, using the microwave oven heating method.	Formaldehyde	245-253	cyclin D1	Homo sapiens	34-39
7996173-3	1994	In the formalin test, we found that morphine analgesia was associated with a significant reduction in the number of Fos-like-immunoreactive spinoparabrachial projection neurons in the lateral reticulated area of the neck of the dorsal horn.	Formaldehyde	7-15	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	116-119
7541370-2	1994	We studied CD44 expression in 114 formalin-fixed paraffin-embedded thyroid tumors using the A3D8 anti-human CD44 monoclonal antibody.	Formaldehyde	34-42	CD44 molecule (Indian blood group)	Homo sapiens	11-15
7876377-2	1994	METHODS: Immunocytochemistry for p53 was performed in 65 specimens of formalin fixed, paraffin wax embedded cervical tissue using a polyclonal antibody against recombinant p53.	Formaldehyde	70-78	tumor protein p53	Homo sapiens	33-36
7927945-5	1994	We used PC10, a monoclonal antibody (MAb) directed against PCNA, which allows cell proliferation in formalin-fixed, paraffin-embedded tumor tissue to be evaluated.	Formaldehyde	100-108	proliferating cell nuclear antigen	Homo sapiens	59-63
7959668-1	1994	Immunohistochemical expression of the cellular phosphoprotein p53 was investigated in archival, formalin-fixed, and paraffin-embedded surgical breast tissue specimens from 543 patients using the polyclonal antibody CM-1.	Formaldehyde	96-104	tumor protein p53	Homo sapiens	62-65
7820676-1	1994	Immunoreactivity against c-fos-like protein (FOS) was induced in many neuronal cell bodies within the sacral parasympathetic nucleus (SPN) in urethane-anesthetized rats by chemical irritation of the urinary bladder with formalin.	Formaldehyde	220-228	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	25-43
7922972-6	1994	METHODS: p53 expression in formalin fixed, paraffin embedded samples of 204 patients with primary squamous cell carcinoma of the esophagus, who underwent esophageal resection, were analyzed immunohistochemically with DO-1, a monoclonal antibody that detects wild-type and mutant forms of p53.	Formaldehyde	27-35	tumor protein p53	Homo sapiens	9-12
7820676-1	1994	Immunoreactivity against c-fos-like protein (FOS) was induced in many neuronal cell bodies within the sacral parasympathetic nucleus (SPN) in urethane-anesthetized rats by chemical irritation of the urinary bladder with formalin.	Formaldehyde	220-228	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	45-48
7524464-1	1994	Immunohistochemical detection of proliferating cell nuclear antigen (PCNA), a cell cycle-related protein used to estimate tumor growth fraction, is variable in formalin-fixed compared with methanol-fixed tissue specimens.	Formaldehyde	160-168	proliferating cell nuclear antigen	Homo sapiens	33-67
7524464-1	1994	Immunohistochemical detection of proliferating cell nuclear antigen (PCNA), a cell cycle-related protein used to estimate tumor growth fraction, is variable in formalin-fixed compared with methanol-fixed tissue specimens.	Formaldehyde	160-168	proliferating cell nuclear antigen	Homo sapiens	69-73
7524464-6	1994	Immunoblotting of formalin fixatives and saline washings after removal of tissue specimens consistently demonstrated the presence of PCNA-like activity in solution.	Formaldehyde	18-26	proliferating cell nuclear antigen	Homo sapiens	133-137
7524464-7	1994	We conclude that the exceptional solubility of PCNA is responsible for reduced immunostaining in formalin-fixed material, that the loss is irreversible, and that methanol or methacarn is the fixative of choice for PCNA immunohistochemistry.	Formaldehyde	97-105	proliferating cell nuclear antigen	Homo sapiens	47-51
7826474-1	1994	6-Acetyl-2(3H)-benzoxazolone derivatives were reacted with appropriate piperidine derivatives and formaldehyde in methanol to give the corresponding 6-acyl-3-piperidinomethyl-2(3H)-benzoxazolones.	Formaldehyde	98-110	O-acyltransferase like	Mus musculus	151-157
7965709-8	1994	These data indicate that ET-A and ET-B receptors have a powerful effect on spinal nociceptive processing evoked by formaldehyde solution injection but not that evoked by thermal stimulation.	Formaldehyde	115-127	endothelin receptor type A	Homo sapiens	25-29
7523275-2	1994	The expression of CD44 in 23 gastric adenocarcinoma and 12 peptic ulcer disease (PUD) resection specimens and gastric carcinoma cell lines HS746t and KATO III was examined by immunohistochemistry using the murine monoclonal antibody A3D8 on formalin-fixed, paraffin-embedded tissue or cells.	Formaldehyde	241-249	CD44 molecule (Indian blood group)	Homo sapiens	18-22
7962609-6	1994	H pylori induced IL-8 secretion was reduced by heat killing, sonication, freeze thawing or formalin fixation of the bacteria.	Formaldehyde	91-99	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
7965709-8	1994	These data indicate that ET-A and ET-B receptors have a powerful effect on spinal nociceptive processing evoked by formaldehyde solution injection but not that evoked by thermal stimulation.	Formaldehyde	115-127	endothelin receptor type B	Homo sapiens	34-38
7889219-3	1994	Incorporation of IUdR was also determined flow cytometrically (IUdRfcm) and PCNA expression was measured in both formalin- and methanol-fixed tissue (PCNAf and PCNAm respectively).	Formaldehyde	113-121	proliferating cell nuclear antigen	Homo sapiens	76-80
7838839-0	1994	Immunocytochemical detection of cyclin A and cyclin D in formalin-fixed, paraffin-embedded tissues: novel, pertinent markers of cell proliferation.	Formaldehyde	57-65	cyclin A2	Homo sapiens	32-40
7838839-0	1994	Immunocytochemical detection of cyclin A and cyclin D in formalin-fixed, paraffin-embedded tissues: novel, pertinent markers of cell proliferation.	Formaldehyde	57-65	proliferating cell nuclear antigen	Homo sapiens	32-38
7838839-4	1994	Conditions were optimized for detecting cyclin A and cyclin D in formalin-fixed, paraffin-embedded sections of the postnatal human palatine tonsil, in which normal cell proliferation is well characterized.	Formaldehyde	65-73	cyclin A2	Homo sapiens	40-48
7838839-4	1994	Conditions were optimized for detecting cyclin A and cyclin D in formalin-fixed, paraffin-embedded sections of the postnatal human palatine tonsil, in which normal cell proliferation is well characterized.	Formaldehyde	65-73	proliferating cell nuclear antigen	Homo sapiens	40-46
7580888-2	1994	Sequences of the p53 gene have been obtained from DNA extracted from frozen and formalin-fixed paraffin-embedded cancer tissues.	Formaldehyde	80-88	tumor protein p53	Homo sapiens	17-20
7530851-8	1994	Fixation-induced loss of p53 immunoreactivity was minimal for formalin (two of 10 tumors for one antibody each), more significant for Bouin (six of 10 tumors for one to five antibodies).	Formaldehyde	62-70	tumor protein p53	Homo sapiens	25-28
7834077-0	1994	Heat-induced antigen retrieval of proliferating cell nuclear antigen and p53 protein in formalin-fixed, paraffin-embedded sections.	Formaldehyde	88-96	proliferating cell nuclear antigen	Homo sapiens	34-68
7824204-2	1994	Noxious stimulation of the hindpaw with formalin induces c-Fos in neurons in superficial laminae (I and II) of these dorsal horn segments.	Formaldehyde	40-48	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	57-62
7927875-1	1994	The expression level of stromelysin-3 (ST3) mRNA was analyzed by in situ hybridization of formalin-fixed, paraffin-embedded primary breast-tumor samples from 76 patients.	Formaldehyde	90-98	matrix metallopeptidase 11	Homo sapiens	24-37
7927875-1	1994	The expression level of stromelysin-3 (ST3) mRNA was analyzed by in situ hybridization of formalin-fixed, paraffin-embedded primary breast-tumor samples from 76 patients.	Formaldehyde	90-98	matrix metallopeptidase 11	Homo sapiens	39-42
8068606-3	1994	The location and source of LPL in human myocardium were determined on formalin-fixed samples from 25 cardiomyopathy patients and seven control patients.	Formaldehyde	70-78	lipoprotein lipase	Homo sapiens	27-30
7531934-0	1994	When NADPH diaphorase (NADPHd) works in the presence of formaldehyde, the enzyme appears to visualize selectively cells with constitutive nitric oxide synthase (NOS).	Formaldehyde	56-68	nitric oxide synthase 2	Homo sapiens	138-159
7827355-2	1994	Incubation of bovine serum albumin (BSA; 1.5 mM) with sugars (50 mM in 0.2 M phosphate buffer, pH 7.4, at 37 degrees C) resulted in a time-dependent increase of formaldehyde release (moles/moles of protein).	Formaldehyde	161-173	albumin	Homo sapiens	21-34
7822215-0	1994	Sensitive detection of human growth hormone mRNA in routinely formalin-fixed, paraffin-embedded transgenic mouse tissues by non-isotopic in situ hybridization.	Formaldehyde	62-70	growth hormone 1	Homo sapiens	29-43
8080362-5	1994	We describe a useful alternative to determine fiber types in skeletal muscle specimens by myosin histochemistry on formalin- or Bouin-fixed, paraffin-embedded tissue.	Formaldehyde	115-123	myosin heavy chain 14	Homo sapiens	90-96
8069923-2	1994	We have focused on the effects of irradiated, IL2-activated PBMC (PBMC*rIL2) on anti-CD3- and formalin-fixed heat-killed Staphylococcus aureus-induced polyclonal B cell differentiation in secondary cultures.	Formaldehyde	94-102	interleukin 2	Homo sapiens	46-49
8069923-2	1994	We have focused on the effects of irradiated, IL2-activated PBMC (PBMC*rIL2) on anti-CD3- and formalin-fixed heat-killed Staphylococcus aureus-induced polyclonal B cell differentiation in secondary cultures.	Formaldehyde	94-102	interleukin 2	Rattus norvegicus	71-75
8063416-2	1994	PBMC and Mphi from all these donor groups secreted increased levels of tumor necrosis factor alpha, interleukin-1 beta, and interleukin-6 in response to stimulation with formalin-killed spherules (FKS), as measured by enzyme-linked immunosorbent assays.	Formaldehyde	170-178	tumor necrosis factor	Homo sapiens	71-98
8063416-2	1994	PBMC and Mphi from all these donor groups secreted increased levels of tumor necrosis factor alpha, interleukin-1 beta, and interleukin-6 in response to stimulation with formalin-killed spherules (FKS), as measured by enzyme-linked immunosorbent assays.	Formaldehyde	170-178	interleukin 1 beta	Homo sapiens	100-118
8063416-2	1994	PBMC and Mphi from all these donor groups secreted increased levels of tumor necrosis factor alpha, interleukin-1 beta, and interleukin-6 in response to stimulation with formalin-killed spherules (FKS), as measured by enzyme-linked immunosorbent assays.	Formaldehyde	170-178	interleukin 6	Homo sapiens	124-137
7961123-1	1994	We have examined the occurrence of apoptotic cell death in formalin-fixed, paraffin-embedded human gastric carcinoma specimens by the terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-biotin nick end labeling (TUNEL) method.	Formaldehyde	59-67	DNA nucleotidylexotransferase	Homo sapiens	134-171
7961123-1	1994	We have examined the occurrence of apoptotic cell death in formalin-fixed, paraffin-embedded human gastric carcinoma specimens by the terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-biotin nick end labeling (TUNEL) method.	Formaldehyde	59-67	DNA nucleotidylexotransferase	Homo sapiens	173-176
7831155-5	1994	We conclude that PCNA detected by the monoclonal antibody PC 10 in formalin-fixed material looks at present unreliable as a proliferation marker in breast carcinoma.	Formaldehyde	67-75	proliferating cell nuclear antigen	Homo sapiens	17-21
8074222-4	1994	Compared with media and latex bead controls, TNF levels progressively increased for up to 240 min after either LPS and equivalently in live E. coli or Formalin-fixed E. coli groups (P &lt; 0.05).	Formaldehyde	151-159	tumor necrosis factor	Rattus norvegicus	45-48
7822215-1	1994	A sensitive technique of non-isotopic in situ hybridization (NISH) is presented, which permits the detection of human growth hormone (hGH) mRNA in routinely formalin-fixed, paraffin-embedded transgenic mouse tissues and human post mortem pituitaries; the latter were used as positive tissue controls in this study.	Formaldehyde	157-165	growth hormone 1	Homo sapiens	118-132
7832981-1	1994	The Lys residues in the 75-residue Ca(2+)-binding protein calbindin D9k were reductively methylated with 13C-enriched formaldehyde.	Formaldehyde	118-130	S100 calcium binding protein G	Homo sapiens	58-71
8027537-5	1994	Moreover, we studied the possibility of detecting AR in prolonged formalin-fixed tissue and in paraffin-embedded archival material.	Formaldehyde	66-74	androgen receptor	Homo sapiens	50-52
7965394-0	1994	Production of two monoclonal antibodies (FB1 and FB21) useful for the identification of human B lymphocytes in formalin-fixed, paraffin-embedded tissues.	Formaldehyde	111-119	TCF3 fusion partner	Homo sapiens	41-44
7965394-1	1994	Two monoclonal antibodies (FB1 and FB21) reactive in formalin-fixed, paraffin-embedded tissue sections are reported in this paper.	Formaldehyde	53-61	TCF3 fusion partner	Homo sapiens	27-30
8030271-4	1994	Thus, the present study was designed to investigate the presence of HPV and p53 gene mutations in 17 formalin-fixed, paraffin-embedded KS [7 acquired immunodeficiency syndrome-KS (AIDS-KS) and 10 classic KS] specimens.	Formaldehyde	101-109	tumor protein p53	Homo sapiens	76-79
7913577-10	1994	Both p53 protein and p185 antibodies work well on routine, formalin-fixed, paraffin-embedded tissue and are easily used in routine diagnostic procedures.	Formaldehyde	59-67	tumor protein p53	Homo sapiens	5-8
8035532-0	1994	Enhanced pulmonary histopathology induced by respiratory syncytial virus (RSV) challenge of formalin-inactivated RSV-immunized BALB/c mice is abrogated by depletion of interleukin-4 (IL-4) and IL-10.	Formaldehyde	92-100	interleukin 4	Mus musculus	168-181
8035532-0	1994	Enhanced pulmonary histopathology induced by respiratory syncytial virus (RSV) challenge of formalin-inactivated RSV-immunized BALB/c mice is abrogated by depletion of interleukin-4 (IL-4) and IL-10.	Formaldehyde	92-100	interleukin 4	Mus musculus	183-187
8035532-0	1994	Enhanced pulmonary histopathology induced by respiratory syncytial virus (RSV) challenge of formalin-inactivated RSV-immunized BALB/c mice is abrogated by depletion of interleukin-4 (IL-4) and IL-10.	Formaldehyde	92-100	interleukin 10	Mus musculus	193-198
7708442-2	1994	Formalin fixed and paraffin embedded liver sections have been immunostained for the proliferation associated antigen PCNA (Proliferating Cell Nuclear Antigen-clone PC10) and counterstained with toluidine blue that enhances histologic recognition of mitoses.	Formaldehyde	0-8	proliferating cell nuclear antigen	Oryctolagus cuniculus	117-121
7708442-2	1994	Formalin fixed and paraffin embedded liver sections have been immunostained for the proliferation associated antigen PCNA (Proliferating Cell Nuclear Antigen-clone PC10) and counterstained with toluidine blue that enhances histologic recognition of mitoses.	Formaldehyde	0-8	proliferating cell nuclear antigen	Oryctolagus cuniculus	123-168
7518196-7	1994	Nuclear cyclin D1 protein can be detected in all cases of MCL and in rare cases of B-SLL/CLL using an immunohistochemical technique on formalin-fixed, paraffin-embedded tissue, and it does not appear to be detectable in reactive hyperplasias and other low-grade B-cell lymphomas.	Formaldehyde	135-143	cyclin D1	Homo sapiens	8-17
7708439-9	1994	P53 was investigated by immunohistochemistry, using a monoclonal anti-p53 antibody (DO-7), on formalin fixed, paraffin embedded tissue.	Formaldehyde	94-102	tumor protein p53	Homo sapiens	0-3
7913577-10	1994	Both p53 protein and p185 antibodies work well on routine, formalin-fixed, paraffin-embedded tissue and are easily used in routine diagnostic procedures.	Formaldehyde	59-67	eukaryotic translation initiation factor 3 subunit A	Homo sapiens	21-25
7960940-1	1994	The objective of our study was to determine the cellular localisation of glucose-6-phosphatase in developing human kidney using monospecific antiserum and a standard immunohistochemical method (peroxidase-antiperoxidase, PAP) on formalin fixed and paraffin embedded tissue.	Formaldehyde	229-237	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	73-94
8004587-2	1994	METHODS: Using a polyclonal serum to the 37-67 region of PTHrP, and 35S-labeled riboprobes, the authors investigated the cellular expression of PTHrP mRNA and peptide in formalin fixed, paraffin embedded sections from 16 invasive cervical tumors.	Formaldehyde	170-178	parathyroid hormone like hormone	Homo sapiens	144-149
7806086-2	1994	Nevertheless, protocols for detecting GM-CSF receptors on formalin-fixed paraffin-embedded histological sections, to our knowledge, have not been described.	Formaldehyde	58-66	colony stimulating factor 2	Homo sapiens	38-44
7911272-3	1994	We used immunocytochemical techniques to retrospectively study the expression of the c-erb B-2 oncogene product in formalin-fixed, paraffin-embedded trophoblastic tissues as a potential indicator of the development of persistent gestational trophoblastic disease.	Formaldehyde	115-123	erb-b2 receptor tyrosine kinase 2	Homo sapiens	85-94
7520332-6	1994	Optimal conditions for in situ localization of the RAR mRNA were established using cultured tumor cells, and these conditions were then used for the detection of RAR mRNA in formalin-fixed, paraffin-embedded sections of surgical specimens from human tumors.	Formaldehyde	174-182	retinoic acid receptor alpha	Homo sapiens	162-165
8200229-3	1994	METHODS: IgG1 monoclonal antibody to human p53 protein (PAb 1801) was used to detect p53 in formalin-fixed, paraffin-embedded archival tumors resected from 84 patients with tumor limited to the bowel wall.	Formaldehyde	92-100	tumor protein p53	Homo sapiens	43-46
8200229-3	1994	METHODS: IgG1 monoclonal antibody to human p53 protein (PAb 1801) was used to detect p53 in formalin-fixed, paraffin-embedded archival tumors resected from 84 patients with tumor limited to the bowel wall.	Formaldehyde	92-100	tumor protein p53	Homo sapiens	85-88
7953655-0	1994	Formalin induced FOS-like immunoreactive neurons in the trigeminal spinal caudal subnucleus project to contralateral parabrachial nucleus in the rat.	Formaldehyde	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	17-20
7953655-5	1994	The results suggest that FOS-like immunoreactivity might serve as an indicator for the nociceptive response after formalin injection into the trigeminal region and that the PB might be an important relay station for the further processing of the nociceptive information relayed from the trigeminal afferents.	Formaldehyde	114-122	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	25-28
7911456-1	1994	P-glycoprotein expression was analyzed on 137 formalin-fixed, paraffin-embedded human tumours by monoclonal antibody (MAb) MC57.	Formaldehyde	46-54	ATP binding cassette subfamily B member 1	Homo sapiens	0-14
7919962-1	1994	Mutations in N-ras exon 2 codon 61 were studied in formalin-fixed human melanoma metastases.	Formaldehyde	51-59	NRAS proto-oncogene, GTPase	Homo sapiens	13-18
8189040-0	1994	Androgen receptor immunostaining and its tissue distribution in formalin-fixed, paraffin-embedded sections after microwave treatment.	Formaldehyde	64-72	androgen receptor	Homo sapiens	0-17
8189040-1	1994	We used microwave (MW) oven heat treatment to unmask human androgen receptor (AR) immunostaining in formalin-fixed, paraffin-embedded tissue.	Formaldehyde	100-108	androgen receptor	Homo sapiens	59-76
8189040-1	1994	We used microwave (MW) oven heat treatment to unmask human androgen receptor (AR) immunostaining in formalin-fixed, paraffin-embedded tissue.	Formaldehyde	100-108	androgen receptor	Homo sapiens	78-80
8189040-8	1994	MW heat treatment of tissue samples in an excellent method of localizing AR antigenicity, enabling immunohistochemical evaluation of AR status in formalin-fixed, paraffin-embedded material.	Formaldehyde	146-154	androgen receptor	Homo sapiens	73-75
8189040-8	1994	MW heat treatment of tissue samples in an excellent method of localizing AR antigenicity, enabling immunohistochemical evaluation of AR status in formalin-fixed, paraffin-embedded material.	Formaldehyde	146-154	androgen receptor	Homo sapiens	133-135
8078392-12	1994	Preperfusion of livers with unlabeled FHSA, pHSA, or formaldehyde-treated bovine serum albumin (FBSA) inhibited the uptake of 15G-FHSA or 15G-pHSA by Ec.	Formaldehyde	53-65	albumin	Rattus norvegicus	81-94
7937720-10	1994	Three of eleven cases, all of which expressed EGFR, were felt to show EGFR gene amplification using a modification of the differential polymerase chain reaction on archival, formalin-fixed, paraffin-embedded tissue.	Formaldehyde	174-182	epidermal growth factor receptor	Homo sapiens	70-74
8074285-2	1994	The assay requires the inclusion of superoxide dismutase, catalase, and 6% methanol in the tested reaction system, to stochiometrically produce formaldehyde per molecule of H2O2 generated.	Formaldehyde	144-156	catalase	Homo sapiens	58-66
7914944-1	1994	The expression of the proliferating cell nuclear antigen (PCNA) was analyzed in formalin-fixed paraffin-embedded materials of 20 primary renal pelvic and ureteral cancers.	Formaldehyde	80-88	proliferating cell nuclear antigen	Homo sapiens	22-56
7914944-1	1994	The expression of the proliferating cell nuclear antigen (PCNA) was analyzed in formalin-fixed paraffin-embedded materials of 20 primary renal pelvic and ureteral cancers.	Formaldehyde	80-88	proliferating cell nuclear antigen	Homo sapiens	58-62
7517967-4	1994	In formalin-fixed and paraffin-embedded sections of rat brain, uMtCK immunostaining is detected in the somata of all Golgi type I neurons in the cerebellum, pontine reticular formation, red nucleus, hippocampus, and cerebral cortex.	Formaldehyde	3-11	creatine kinase, mitochondrial 1	Rattus norvegicus	63-68
7521680-1	1994	Formalin fixation reduces beta-amyloid precursor protein (beta APP) immunoreactivity which restricts its study in archival tissue.	Formaldehyde	0-8	amyloid beta precursor protein	Homo sapiens	26-56
7912941-1	1994	The effect of microwave irradiation on the immunoreactivity of proliferating cell nuclear antigen (PCNA) in five primary breast carcinomas, a tonsil with hyperplasia, and a seminoma of the testis was evaluated in formalin-fixed and paraffin-embedded sections using the monoclonal antibody PC-10.	Formaldehyde	213-221	proliferating cell nuclear antigen	Homo sapiens	63-97
8579131-5	1994	The advantage of using PCNA is that standard archival formalin-fixed, paraffin-embedded tissues may be analyzed and that PCNA detect cells in G1 through S phase, allowing S-phase fractions, determined by flow cytometry.	Formaldehyde	54-62	proliferating cell nuclear antigen	Homo sapiens	23-27
7912941-0	1994	Microwave processing for immunohistochemical demonstration of proliferating cell nuclear antigen (PCNA) in formalin-fixed and paraffin-embedded tissue.	Formaldehyde	107-115	proliferating cell nuclear antigen	Homo sapiens	62-96
7912941-0	1994	Microwave processing for immunohistochemical demonstration of proliferating cell nuclear antigen (PCNA) in formalin-fixed and paraffin-embedded tissue.	Formaldehyde	107-115	proliferating cell nuclear antigen	Homo sapiens	98-102
7912941-9	1994	We therefore recommend microwave processing in distilled water for x2 5 min for demonstration of PCNA in formalin-fixed and paraffin-embedded sections using the monoclonal antibody PC-10, since this technique yields optimal staining reactions independent of the length of fixation.	Formaldehyde	105-113	proliferating cell nuclear antigen	Homo sapiens	97-101
7914524-4	1994	The former recognizes a formalin-resistant epitope of PCNA, and MIB1 the same antigen as Ki67 in formalin-fixed, paraffin wax-embedded sections after incubation in a microwave oven.	Formaldehyde	24-32	proliferating cell nuclear antigen	Canis lupus familiaris	54-58
7909490-4	1994	METHODS: The immunostaining for HER-2/neu oncoprotein was performed on formaldehyde-solution-fixed, paraffin-embedded sections of 888 node-positive breast cancers resected between 1980 and 1986 and for which a follow-up of 2.5-10.5 years was available.	Formaldehyde	71-83	erb-b2 receptor tyrosine kinase 2	Homo sapiens	32-41
8188462-1	1994	PURPOSE: To determine whether, by employing recent advances in immunocytochemical technique, it is possible to identify reliably the product of the retinoblastoma (RB) susceptibility gene, p110RB1, in formalin-fixed, paraffin-embedded eyes with commercially available primary antibodies.	Formaldehyde	201-209	RB transcriptional corepressor 1	Homo sapiens	148-162
11578406-1	1994	The expression of c-erbB-2 oncogene has been studied in 74 formalin fixed paraffin embedded invasive epithelial ovarian malignancies using a monoclonal c-erbB-2 protein antibody.	Formaldehyde	59-67	erb-b2 receptor tyrosine kinase 2	Homo sapiens	18-26
7520586-7	1994	Reactivity for LMP was demonstrated in cryostat sections and was also well preserved in paraffin sections of B5- or formalin-fixed tissues.	Formaldehyde	116-124	PDZ and LIM domain 7	Homo sapiens	15-18
7931834-1	1994	Immunohistochemical study of 30 cases using the MIB 1 antibody in formalin-fixed paraffin sections.	Formaldehyde	66-74	MIB E3 ubiquitin protein ligase 1	Homo sapiens	48-53
7931834-4	1994	The MIB 1 monoclonal antibody recognizes the Ki-67 antigen in formalin-fixed, paraffin-embedded tissues.	Formaldehyde	62-70	MIB E3 ubiquitin protein ligase 1	Homo sapiens	4-9
7910515-6	1994	Therefore, use of PCNA immunohistochemistry should allow retrospective staining of rodent tissues for the assessment of cell proliferative activity in formalin-fixed organs from previously conducted toxicity and carcinogenicity studies.	Formaldehyde	151-159	proliferating cell nuclear antigen	Rattus norvegicus	18-22
7519746-5	1994	The number of PCNA-positive cells in PLP-fixed material was greater than in 10% formalin-fixed material, but showed a poorer correlation with BrdU labeling index.	Formaldehyde	80-88	proliferating cell nuclear antigen	Rattus norvegicus	14-18
7910957-1	1994	Cell proliferation of 174 specimens obtained from the primary gastric cancers using endoscopic biopsy was investigated by immunohistochemical analysis with the monoclonal antibody PC10, which recognizes a proliferating cell nuclear antigen (PCNA) in formalin-fixed and paraffin-embedded material.	Formaldehyde	250-258	proliferating cell nuclear antigen	Homo sapiens	205-239
7910957-1	1994	Cell proliferation of 174 specimens obtained from the primary gastric cancers using endoscopic biopsy was investigated by immunohistochemical analysis with the monoclonal antibody PC10, which recognizes a proliferating cell nuclear antigen (PCNA) in formalin-fixed and paraffin-embedded material.	Formaldehyde	250-258	proliferating cell nuclear antigen	Homo sapiens	241-245
8053129-0	1994	Distribution of anti-CD68 (EBM11) immunoreactivity in formalin-fixed, paraffin-embedded bovine tissues.	Formaldehyde	54-62	CD68 molecule	Bos taurus	21-25
8053129-1	1994	A commercially acquired anti-human macrophage antibody (anti-CD68; EBM11) was used in an immunocytochemical technique to detect macrophages in formalin-fixed, paraffin-embedded tissues from cattle, pigs, humans, rats, turkeys, dogs, and cats.	Formaldehyde	143-151	CD68 molecule	Bos taurus	61-65
8032900-0	1994	Changes in c-fos induction in dorsal horn neurons by hindpaw formalin stimulation following tibial neurotomy.	Formaldehyde	61-69	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	11-16
7518602-0	1994	Changes of spinal substance P, calcitonin gene-related peptide, somatostatin, Met-enkephalin and neurotensin in rats in response to formalin-induced pain.	Formaldehyde	132-140	neurotensin	Rattus norvegicus	97-108
8032900-3	1994	The excitability of dorsal horn neurons was expressed as the percentage ratio of the number of formalin-induced c-fos protein-like immunoreactive neurons (fos-neurons) on the neurotomized (experimental) side to that on the un-neurotomized (control) side.	Formaldehyde	95-103	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	112-117
8137214-4	1994	METHODS: The presence of PTHrp in SCC has been studied by immunohistochemistry in formalin fixed, paraffin embedded tissues.	Formaldehyde	82-90	parathyroid hormone like hormone	Homo sapiens	25-30
8043159-9	1994	Since p53 (PAb 1801) expression can withstand formalin fixation and pepsin treatment of paraffin-embedded tissues, flow cytometric analysis of archival specimens is feasible, and clinical correlations such as these may be carried out in retrospective studies of other tumors.	Formaldehyde	46-54	tumor protein p53	Homo sapiens	6-9
7907940-4	1994	Overexpression of c-erbB-2 oncoprotein was studied by immunohistochemical alkaline phosphatase-antialkaline phosphatase staining of formalin fixed, paraffin embedded tissue sections of the primary tumor.	Formaldehyde	132-140	erb-b2 receptor tyrosine kinase 2	Homo sapiens	18-26
8137214-4	1994	METHODS: The presence of PTHrp in SCC has been studied by immunohistochemistry in formalin fixed, paraffin embedded tissues.	Formaldehyde	82-90	serpin family B member 3	Homo sapiens	34-37
7936762-8	1994	PCNA was detected immunohistochemically on formalin fixed and paraffin embedded biopsies, and positive cells were evaluated in a crude percent count.	Formaldehyde	43-51	proliferating cell nuclear antigen	Homo sapiens	0-4
7910934-1	1994	The expression of proliferating cell nuclear antigen (PCNA) was examined in normal human and rat liver fixed in either formaldehyde or methanol, and was compared with the incorporation of bromodeoxyuridine (BrdU) in S-phase cells.	Formaldehyde	119-131	proliferating cell nuclear antigen	Homo sapiens	18-52
7910934-1	1994	The expression of proliferating cell nuclear antigen (PCNA) was examined in normal human and rat liver fixed in either formaldehyde or methanol, and was compared with the incorporation of bromodeoxyuridine (BrdU) in S-phase cells.	Formaldehyde	119-131	proliferating cell nuclear antigen	Homo sapiens	54-58
7910934-3	1994	In formaldehyde-fixed human biopsies (n = 13) PCNA-labelling index (PCNA LI) was 0.43 +/- 0.24% (mean +/- SEM) for hepatocytes and 0.09 +/- 0.03% for sinusoidal cells.	Formaldehyde	3-15	proliferating cell nuclear antigen	Homo sapiens	46-50
7910934-3	1994	In formaldehyde-fixed human biopsies (n = 13) PCNA-labelling index (PCNA LI) was 0.43 +/- 0.24% (mean +/- SEM) for hepatocytes and 0.09 +/- 0.03% for sinusoidal cells.	Formaldehyde	3-15	proliferating cell nuclear antigen	Homo sapiens	68-72
7909306-1	1994	The expression of proliferating cell nuclear antigen (PCNA) was studied in human papillomavirus (HPV)-infected, benign and malignant lesions of the genital tract and larynx using immunocytochemical staining of formalin-fixed clinical specimens.	Formaldehyde	210-218	proliferating cell nuclear antigen	Homo sapiens	54-58
7909307-0	1994	c-erbB-2 amplification in breast cancer: detection in formalin-fixed, paraffin-embedded tissue by in situ hybridization.	Formaldehyde	54-62	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-8
7909307-1	1994	We describe a sensitive and practical in situ hybridization method, using a digoxigenin-labeled probe, for the detection of c-erbB-2 amplification in breast cancer in formalin-fixed, paraffin-embedded tissue sections.	Formaldehyde	167-175	erb-b2 receptor tyrosine kinase 2	Homo sapiens	124-132
8058716-1	1994	We sought to establish an easily interpretable and highly sensitive immunohistochemical method for detecting progesterone receptor protein in formalin-fixed, paraffin-embedded samples of breast carcinomas.	Formaldehyde	142-150	progesterone receptor	Homo sapiens	109-130
8058126-8	1994	Synaptophysin immunoreactivity also reduced with age, as well as with duration of formalin fixation but not post mortem interval.	Formaldehyde	82-90	synaptophysin	Homo sapiens	0-13
8156496-3	1994	METHODS: The status of the p53 gene was studied by immunohistochemistry of formalin-fixed paraffin-embedded biopsy samples from 72 patients with atypical endometrial hyperplasia or endometrioid carcinoma who underwent hysterectomy immediately after biopsy and from 5 patients with benign endometria.	Formaldehyde	75-83	tumor protein p53	Homo sapiens	27-30
7911731-3	1994	METHODS: In this study, PCNA was identified by utilizing streptavidin-biotin immunoperoxidase technique on formalin-fixed, paraffin-embedded tissue sections of 32 hepatocellular carcinomas that were obtained from resected surgical specimens.	Formaldehyde	107-115	proliferating cell nuclear antigen	Homo sapiens	24-28
7509813-12	1994	During the development of an experimental formalin-immune complex colitis, rabbit IL-1 alpha showed a dramatic increase in tissue levels, consistent with previous results; IL-1ra also increased 3-4-fold.	Formaldehyde	42-50	interleukin-1 receptor antagonist intracellular form	Oryctolagus cuniculus	172-178
7509813-12	1994	During the development of an experimental formalin-immune complex colitis, rabbit IL-1 alpha showed a dramatic increase in tissue levels, consistent with previous results; IL-1ra also increased 3-4-fold.	Formaldehyde	42-50	interleukin-1 alpha	Oryctolagus cuniculus	82-92
8195931-3	1994	BCL-2 protein was detected in all the 46 formalin-fixed, paraffin-embedded samples from 34 patients representing all clinical stages and sites of involvement.	Formaldehyde	41-49	BCL2 apoptosis regulator	Homo sapiens	0-5
8006643-8	1994	These data confirm 1) the feasibility of detecting HCV RNA in formalin-fixed, paraffin-embedded tissue from patients with chronic HCV infection, 2) show that sustained response to IFN is associated with loss of liver HCV RNA at the end of IFN therapy, and 3) offer an explanation for recurrence in patients who relapse.	Formaldehyde	62-70	interferon alpha 1	Homo sapiens	180-183
8198873-1	1994	A formaldehyde-fixed cell vaccine in adjuvant (syngeneic cells infected with a vaccinia virus recombinant expressing gp160: vacc-gp160) stimulated only nonneutralizing antibody when used on its own in four strains of mice, but a similar nonfixed cell vaccine stimulated neutralizing antibodies up to a titer of 1/320 in C57BL/6 (H-2b) mice previously infected with live vacc-gp160.	Formaldehyde	2-14	leucyl/cystinyl aminopeptidase	Mus musculus	117-122
7906919-4	1994	Using a new monoclonal anti-EGFR antibody reactive in formalin-fixed tissue, the authors found a significant correlation between EGFR expression and high tumor stage, and between EGFR expression and poor patient outcome.	Formaldehyde	54-62	epidermal growth factor receptor	Homo sapiens	28-32
7906919-4	1994	Using a new monoclonal anti-EGFR antibody reactive in formalin-fixed tissue, the authors found a significant correlation between EGFR expression and high tumor stage, and between EGFR expression and poor patient outcome.	Formaldehyde	54-62	epidermal growth factor receptor	Homo sapiens	129-133
7906919-4	1994	Using a new monoclonal anti-EGFR antibody reactive in formalin-fixed tissue, the authors found a significant correlation between EGFR expression and high tumor stage, and between EGFR expression and poor patient outcome.	Formaldehyde	54-62	epidermal growth factor receptor	Homo sapiens	129-133
8145547-9	1994	In addition, formalin fixation studies suggested that IFN-gamma may impair collagen cross-linking.	Formaldehyde	13-21	interferon gamma	Homo sapiens	54-63
8198873-1	1994	A formaldehyde-fixed cell vaccine in adjuvant (syngeneic cells infected with a vaccinia virus recombinant expressing gp160: vacc-gp160) stimulated only nonneutralizing antibody when used on its own in four strains of mice, but a similar nonfixed cell vaccine stimulated neutralizing antibodies up to a titer of 1/320 in C57BL/6 (H-2b) mice previously infected with live vacc-gp160.	Formaldehyde	2-14	leucyl/cystinyl aminopeptidase	Mus musculus	129-134
8198873-1	1994	A formaldehyde-fixed cell vaccine in adjuvant (syngeneic cells infected with a vaccinia virus recombinant expressing gp160: vacc-gp160) stimulated only nonneutralizing antibody when used on its own in four strains of mice, but a similar nonfixed cell vaccine stimulated neutralizing antibodies up to a titer of 1/320 in C57BL/6 (H-2b) mice previously infected with live vacc-gp160.	Formaldehyde	2-14	leucyl/cystinyl aminopeptidase	Mus musculus	129-134
7516561-2	1994	Immunohistochemical staining of routinely processed formalin-fixed, paraffin-embedded archival tissue sections with proliferating cell nuclear antigen (PCNA) monoclonal antibody has facilitated the understanding of the regulation of cell proliferation.	Formaldehyde	52-60	proliferating cell nuclear antigen	Homo sapiens	116-150
7508682-0	1994	New immunohistochemical "sandwich" staining method for mdr1 P-glycoprotein detection with JSB-1 monoclonal antibody in formalin-fixed, paraffin-embedded human tissues.	Formaldehyde	119-127	ATP binding cassette subfamily B member 1	Homo sapiens	60-74
7508682-1	1994	We have developed a new immunoperoxidase "sandwich" staining method for amplified detection of P-glycoprotein (Pgp) that is suitable for use on formalin-fixed, paraffin-embedded (conventional) tissue sections.	Formaldehyde	144-152	ATP binding cassette subfamily B member 1	Homo sapiens	95-109
7508682-1	1994	We have developed a new immunoperoxidase "sandwich" staining method for amplified detection of P-glycoprotein (Pgp) that is suitable for use on formalin-fixed, paraffin-embedded (conventional) tissue sections.	Formaldehyde	144-152	ATP binding cassette subfamily B member 1	Homo sapiens	111-114
7508682-11	1994	This new immunoperoxidase sandwich staining method using JSB-1 now allows reliable Pgp detection in sections of formalin-fixed, paraffin-embedded (archived) surgical specimens and small biopsy materials commonly used for diagnostic purposes.	Formaldehyde	112-120	ATP binding cassette subfamily B member 1	Homo sapiens	83-86
7512525-4	1994	In contrast, secondary challenge with S. typhimurium C5 (C5) generated cell populations where both L3T4+ and Lyt-2+ T cells proliferated when cultured with formalin-killed 11RX.	Formaldehyde	156-164	CD8 antigen, alpha chain	Mus musculus	109-114
7911817-1	1994	The immunohistochemical determination of the accessory protein of DNA-polymerase delta (PCNA), a marker of an early S-phase of the cell cycle, was used to evaluate cell proliferation retrospectively in formalin-fixed, paraffin-embedded liver biopsy sections in a group of patients with cirrhosis of similar age and duration of follow up, and with no evidence of hepatocellular carcinoma (41), including 17 patients with and 24 without hepatocellular carcinoma appearance during follow up.	Formaldehyde	202-210	DNA polymerase delta 1, catalytic subunit	Homo sapiens	66-86
7911817-1	1994	The immunohistochemical determination of the accessory protein of DNA-polymerase delta (PCNA), a marker of an early S-phase of the cell cycle, was used to evaluate cell proliferation retrospectively in formalin-fixed, paraffin-embedded liver biopsy sections in a group of patients with cirrhosis of similar age and duration of follow up, and with no evidence of hepatocellular carcinoma (41), including 17 patients with and 24 without hepatocellular carcinoma appearance during follow up.	Formaldehyde	202-210	proliferating cell nuclear antigen	Homo sapiens	88-92
7905364-1	1994	BACKGROUND: A polyclonal antihuman c-erbB-2 oncoprotein antibody recognized c-erbB-2 oncoprotein in routinely formaldehyde-fixed, paraffin-embedded specimens.	Formaldehyde	110-122	erb-b2 receptor tyrosine kinase 2	Homo sapiens	35-43
7905364-1	1994	BACKGROUND: A polyclonal antihuman c-erbB-2 oncoprotein antibody recognized c-erbB-2 oncoprotein in routinely formaldehyde-fixed, paraffin-embedded specimens.	Formaldehyde	110-122	erb-b2 receptor tyrosine kinase 2	Homo sapiens	76-84
8301359-8	1994	Formalin (2 or 6 hr) or CFA (4 d) injection produced approximately a twofold increase in SP-encoding PPT mRNA expression in the ipsilateral lumbar DRG.	Formaldehyde	0-8	tachykinin, precursor 1	Rattus norvegicus	101-104
8008749-1	1994	p53 expression in formalin-fixed, paraffin-embedded archival specimens of intrahepatic cholangiocarcinoma: retrieval of p53 antigenicity by microwave oven heating of tissue sections.	Formaldehyde	18-26	tumor protein p53	Homo sapiens	0-3
8008749-4	1994	We investigated expression of p53 in formalin-fixed, paraffin-embedded archival specimens of 40 CCs (22 autopsy cases and 18 surgical cases) by immunohistochemistry using four antibodies (PAb1801, DO-7, BP53-12, CM1).	Formaldehyde	37-45	tumor protein p53	Homo sapiens	30-33
8008749-10	1994	These results shows that a pretreatment of tissue sections by microwave oven heating is a very good method for demonstrating p53 protein in formalin-fixed, paraffin-embedded archival materials and that DO-7, BP53-12, and CM1 are useful antibodies for detection of p53 in formalin-fixed, paraffin-embedded archival materials.	Formaldehyde	140-148	tumor protein p53	Homo sapiens	125-128
7516561-2	1994	Immunohistochemical staining of routinely processed formalin-fixed, paraffin-embedded archival tissue sections with proliferating cell nuclear antigen (PCNA) monoclonal antibody has facilitated the understanding of the regulation of cell proliferation.	Formaldehyde	52-60	proliferating cell nuclear antigen	Homo sapiens	152-156
7516561-10	1994	In summary, MWH technique in zinc-sulfate solution allowed successful PCNA retrieval from formalin-fixed archival tissue and thus facilitated accurate immunohistochemical evaluation of cell proliferative activity in cancers.	Formaldehyde	90-98	proliferating cell nuclear antigen	Homo sapiens	70-74
8111580-7	1994	Immunohistochemical staining of formalin-fixed, paraffin-embedded tumor samples detected iCT in two of four tumors from patients whose tumor cell lines had CT mRNA by RPA and iCT by RIA, but in none of six whose tumor cell lines had undetectable CT mRNA.	Formaldehyde	32-40	calcitonin related polypeptide alpha	Homo sapiens	90-92
7908155-1	1994	The efficacy of three pretreatment techniques for the detection of prion protein (PrP) in formalin-fixed, paraffin-embedded bovine spongiform encephalopathy (BSE)--affected brain tissue were compared using automated image analysis.	Formaldehyde	90-98	PRP@	Bos taurus	82-85
8111580-7	1994	Immunohistochemical staining of formalin-fixed, paraffin-embedded tumor samples detected iCT in two of four tumors from patients whose tumor cell lines had CT mRNA by RPA and iCT by RIA, but in none of six whose tumor cell lines had undetectable CT mRNA.	Formaldehyde	32-40	calcitonin related polypeptide alpha	Homo sapiens	156-158
7979958-3	1994	The formation of formaldehyde from dichloromethane is influenced by the polymorphism of glutathione-S-transferase (GST) Theta, in the same way as the metabolism of methyl bromide, methyl chloride, methyl iodide and ethylene oxide.	Formaldehyde	17-29	glutathione S-transferase kappa 1	Homo sapiens	88-113
7979958-3	1994	The formation of formaldehyde from dichloromethane is influenced by the polymorphism of glutathione-S-transferase (GST) Theta, in the same way as the metabolism of methyl bromide, methyl chloride, methyl iodide and ethylene oxide.	Formaldehyde	17-29	glutathione S-transferase kappa 1	Homo sapiens	115-118
7979958-5	1994	The metabolism of dichloromethane in hemolysate in vitro can be described by Michaelis-Menten kinetics; for an individual with high GST T1-1 enzyme activity, the maximum velocity of formaldehyde production was calculated to be approximately 180 pmol/min per mg Hb, the kM being approximately 60 mM dichloromethane.	Formaldehyde	182-194	glutathione S-transferase kappa 1	Homo sapiens	132-135
7911757-2	1994	The best fixative for PCNA was found to be buffered formaldehyde solution at 4 degrees C followed by methanol at 20 degrees C, whereas alcoholic fixatives decreased greatly the PCNA immunoreactivity.	Formaldehyde	52-64	proliferating cell nuclear antigen	Homo sapiens	22-26
8140894-4	1994	We have used immunocytochemistry for the beta-amyloid precursor protein (beta APP) as a marker for axonal injury in formalin-fixed, paraffin-embedded sections of human brain.	Formaldehyde	116-124	amyloid beta precursor protein	Homo sapiens	41-71
7525294-2	1994	The samples were taken from needle biopsy specimens which had been paraffin-embedded after routine fixation with 10% formaldehyde solution (formalin) for less than 24 h. The PCNA index was calculated as the percentage of positive tumor cell nuclei.	Formaldehyde	117-129	proliferating cell nuclear antigen	Homo sapiens	174-178
8140894-4	1994	We have used immunocytochemistry for the beta-amyloid precursor protein (beta APP) as a marker for axonal injury in formalin-fixed, paraffin-embedded sections of human brain.	Formaldehyde	116-124	amyloid beta precursor protein	Homo sapiens	73-81
7828605-3	1994	In the present paper the immunohistochemical expression of p185, p21 and proliferating cell nuclear antigen (PCNA) was retrospectively assessed in formalin-fixed, paraffin-embedded tissue samples taken from 28 primary ovarian carcinomas at first surgery.	Formaldehyde	147-155	eukaryotic translation initiation factor 3 subunit A	Homo sapiens	59-63
7828605-3	1994	In the present paper the immunohistochemical expression of p185, p21 and proliferating cell nuclear antigen (PCNA) was retrospectively assessed in formalin-fixed, paraffin-embedded tissue samples taken from 28 primary ovarian carcinomas at first surgery.	Formaldehyde	147-155	proliferating cell nuclear antigen	Homo sapiens	109-113
7525294-2	1994	The samples were taken from needle biopsy specimens which had been paraffin-embedded after routine fixation with 10% formaldehyde solution (formalin) for less than 24 h. The PCNA index was calculated as the percentage of positive tumor cell nuclei.	Formaldehyde	140-148	proliferating cell nuclear antigen	Homo sapiens	174-178
7931255-3	1994	However SSAO in human and rat vascular homogenates readily converts the aliphatic biogenic amines methylamine and aminoacetone to formaldehyde and methylglyoxal, respectively.	Formaldehyde	130-142	amine oxidase copper containing 2	Homo sapiens	8-12
7509767-1	1994	Possible changes in the expression of the HNK-1 carbohydrate epitope in the inner connective tissue layer of the human ciliary body, located between the ciliary epithelium and muscle, was studied using 2 formalin-fixed, paraffin-embedded eyes with exfoliation syndrome, 33 eyes with different types of glaucoma, and 21 morphologically normal control eyes.	Formaldehyde	204-212	beta-1,3-glucuronyltransferase 1	Homo sapiens	42-47
7513322-2	1994	Using this probe, an in situ hybridization protocol was established, tested and optimized for the localization of the cytokeratin 4 mRNA in formalin- or paraformaldehyde-fixed, paraffin-embedded human oesophageal mucosa.	Formaldehyde	140-148	keratin 4	Homo sapiens	118-131
7947334-0	1994	Determination of ABO genotypes with DNA extracted from formalin-fixed, paraffin-embedded tissues.	Formaldehyde	55-63	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	17-20
7523560-5	1994	In a pilot experiment, RNAs isolated from formalin-fixed (FF) and formalin-fixed and paraffin-embedded (FFPE) canine prostatic tissues were shown to be of sufficient quality to permit amplification of KGF mRNA by RT-PCR.	Formaldehyde	66-74	fibroblast growth factor 7	Canis lupus familiaris	201-204
7931256-9	1994	Formaldehyde is produced from methylamine by SSAO.	Formaldehyde	0-12	amine oxidase copper containing 2	Homo sapiens	45-49
7843462-1	1994	Distribution of S-100 protein in porcine ovaries was revealed by an application of polyclonal antibodies against S-100 protein and PAP universal kit to formalin-fixed, paraffin-embedded tissues.	Formaldehyde	152-160	S100 calcium binding protein A1	Homo sapiens	16-21
21566899-3	1994	Immunohistochemical staining of formalin-fixed, paraffin-embedded tissue sections from 48 colorectal carcinomas demonstrated that pRB expression was exclusively localized to the nucleus.	Formaldehyde	32-40	RB transcriptional corepressor 1	Homo sapiens	130-133
7823583-9	1994	A study employing image analysis to detect and quantitate androgen receptors and p53 in formalin-fixed, paraffin-embedded prostate cancer biopsies is underway to determine the utility of androgen receptors in predicting response to hormonal therapy.	Formaldehyde	88-96	tumor protein p53	Homo sapiens	81-84
8145895-5	1994	In mothers continually together with their pups, plasma PRL levels decreased significantly after exposure to ether vapor or injection of formalin under the skin.	Formaldehyde	137-145	prolactin	Rattus norvegicus	56-59
7931823-2	1994	NCL-DK4 has been proved to be highly effective for use on formalin-fixed, paraffin-embedded tissues, enabling the study of c-jun expression at a cellular level in both normal and neoplastic human tissues.	Formaldehyde	58-66	nucleolin	Homo sapiens	0-3
7931823-2	1994	NCL-DK4 has been proved to be highly effective for use on formalin-fixed, paraffin-embedded tissues, enabling the study of c-jun expression at a cellular level in both normal and neoplastic human tissues.	Formaldehyde	58-66	immunoglobulin heavy diversity 5-5	Homo sapiens	4-7
7931823-2	1994	NCL-DK4 has been proved to be highly effective for use on formalin-fixed, paraffin-embedded tissues, enabling the study of c-jun expression at a cellular level in both normal and neoplastic human tissues.	Formaldehyde	58-66	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	123-128
7908712-5	1994	Intrathecally injected somatostatin was able to revert the cysteamine antinociceptive effects in the second phase of the formalin test and in the writhing test, whereas intracerebroventricularly injected somatostatin reduced the antinociceptive effects induced by cysteamine in the second phase of the formalin test.	Formaldehyde	121-129	somatostatin	Mus musculus	23-35
7908712-5	1994	Intrathecally injected somatostatin was able to revert the cysteamine antinociceptive effects in the second phase of the formalin test and in the writhing test, whereas intracerebroventricularly injected somatostatin reduced the antinociceptive effects induced by cysteamine in the second phase of the formalin test.	Formaldehyde	302-310	somatostatin	Mus musculus	204-216
8145895-12	1994	Administration of formalin to adrenalectomized lactating rats continually together with their litter caused a slight immediate decrease, followed by a transitory elevation and a subsequent small second decrease in blood PRL concentration.	Formaldehyde	18-26	prolactin	Rattus norvegicus	220-223
8152541-0	1994	Effects of descending inhibitory systems on the c-Fos expression in the rat spinal cord during formalin-induced noxious stimulation.	Formaldehyde	95-103	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	48-53
21551750-0	1994	Fos-like immunoreactivity in the rat spinal cord induced by formalin injection in the forelimb to gauge possible plasticity of primary afferent fibers following partial deafferentation.	Formaldehyde	60-68	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-3
7907427-3	1994	In contrast, after formalin fixation the two PCNA antibodies additionally stained cells outside the proliferative compartment so that a reliable assessment of cell proliferation was only possible after controlled paraformaldehyde or methacarn fixation.	Formaldehyde	19-27	proliferating cell nuclear antigen	Homo sapiens	45-49
7529427-12	1994	Reduced PCNA antigenicity in archival, formalin-fixed, paraffin-embedded bladder tumour tissue was observed.	Formaldehyde	39-47	proliferating cell nuclear antigen	Homo sapiens	8-12
21551750-5	1994	In control animals, following the formalin injection the greatest number of Fos-LI neurons was encountered in the superficial laminae and in the neck of the dorsal horn of segments C5-T1.	Formaldehyde	34-42	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	76-79
8003863-2	1994	The immunohistochemical localization of PTHrP was studied in sections of formalin-fixed, paraffin-embedded tissues from 28 breast cancers obtained surgically between 1980 and 1985.	Formaldehyde	73-81	parathyroid hormone like hormone	Homo sapiens	40-45
7514077-0	1994	Preferential localization of c-kit product in tissue mast cells, basal cells of skin, epithelial cells of breast, small cell lung carcinoma and seminoma/dysgerminoma in human: immunohistochemical study on formalin-fixed, paraffin-embedded tissues.	Formaldehyde	205-213	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	29-34
7518292-1	1994	The expression and distribution of tenascin, an extracellular matrix glycoprotein, was investigated immunohistochemically using an anti-human tenascin monoclonal antibody (RCB 1) in formalin-fixed paraffin-embedded tissues obtained from 79 patients with skin appendage tumours, and compared with adjacent normal skin.	Formaldehyde	182-190	tenascin C	Homo sapiens	35-43
7527582-4	1994	This mAb is of particular value in that it detects an epitope on p68 which is not destroyed in routinely prepared, formalin-fixed paraffin-embedded tissues, or in a variety of other commonly used clinical fixatives.	Formaldehyde	115-123	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	65-68
7902777-3	1993	METHODS: SCC antigen was immunohistochemically stained in Grade 3 pT1 TCC of the bladder that had been fixed in formaldehyde solution and embedded in paraffin.	Formaldehyde	112-124	serpin family B member 3	Homo sapiens	9-12
7941803-2	1994	PCNA-expression (Proliferating Cell Nuclear Antigen) was immunohistochemically assessed using formalin-fixed, paraffin-embedded tissue.	Formaldehyde	94-102	proliferating cell nuclear antigen	Homo sapiens	0-4
7941803-2	1994	PCNA-expression (Proliferating Cell Nuclear Antigen) was immunohistochemically assessed using formalin-fixed, paraffin-embedded tissue.	Formaldehyde	94-102	proliferating cell nuclear antigen	Homo sapiens	17-51
8010084-0	1994	Topical capsaicin treatment suppresses formalin-induced fos expression in rat spinal cord.	Formaldehyde	39-47	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	56-59
8010084-2	1994	The present study was undertaken to investigate the effects of topical application of Cap to sciatic nerve on the formalin-induced expression of proto-oncogene proteins c-fos in the rat spinal cord using immunohistochemical display of fos-like protein.	Formaldehyde	114-122	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	169-174
8010084-2	1994	The present study was undertaken to investigate the effects of topical application of Cap to sciatic nerve on the formalin-induced expression of proto-oncogene proteins c-fos in the rat spinal cord using immunohistochemical display of fos-like protein.	Formaldehyde	114-122	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	171-174
8010084-3	1994	In rats subjected to formalin injection into the hind paw, numerous fos-like immunoreactivity (FLI) neurons were found in the spinal dorsal horn, with heavy labeling in laminae I-II and V-VI.	Formaldehyde	21-29	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	68-71
8010084-5	1994	It was suggested that activation of Cap-sensitive unmyelinated nociceptive afferents following formalin injection was primarily responsible for the activation of c-fos gene.	Formaldehyde	95-103	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	162-167
8238731-3	1993	The goal of this study was to determine the frequency and relationship of p53 gene alterations and hepatitis B in formalin-fixed, paraffin-embedded HCCs resected in the United States.	Formaldehyde	114-122	tumor protein p53	Homo sapiens	74-77
8314240-1	1993	12E7 is a monoclonal antibody to the MIC2 gene product and can be applied to formalin-fixed, paraffin-embedded tissue.	Formaldehyde	77-85	CD99 molecule (Xg blood group)	Homo sapiens	37-41
7902202-4	1993	METHODS: Immunohistochemical reactivity to c-erbB-2 protein was examined in formalin-fixed, paraffin-embedded tissue sections from patients with gastric cancer.	Formaldehyde	76-84	erb-b2 receptor tyrosine kinase 2	Homo sapiens	43-51
7912188-2	1993	Proliferating cell nuclear antigen (PCNA), an endogenous cell replication marker, and bromodeoxyuridine (BrdU), an exogenously administered DNA precursor label, were detected in formalin-fixed, paraffin-embedded tissues using immunohistochemical techniques.	Formaldehyde	178-186	proliferating cell nuclear antigen	Rattus norvegicus	0-34
8112575-5	1993	Our approach was to identify a set of formaldehyde and gamma radiation induced unc-22 mutations that mapped to the unc-22-let-56 region, and then employ polymerase chain reaction methodology to identify deficiencies that affected one or more of the four identified coding elements.	Formaldehyde	38-50	Twitchin	Caenorhabditis elegans	115-121
8248232-1	1993	In contrast to the multiplicity of alcohol dehydrogenase in vertebrates, a class III type of the enzyme [i.e., a glutathione-dependent formaldehyde dehydrogenase; formaldehyde; NAD+ oxidoreductase (glutathione-formylating), EC 1.2.1.1.]	Formaldehyde	135-147	hydroxysteroid 17-beta dehydrogenase 6	Homo sapiens	182-196
8158458-1	1993	The expression of the nuclear protein p53 in oligodendrogliomas was investigated by immunohistochemistry, using a monoclonal anti-p53 antibody (DO-7) on formalin-fixed, paraffin-embedded material in 84 histologically verified cases, and compared with the histopathological grade and survival.	Formaldehyde	153-161	tumor protein p53	Homo sapiens	38-41
7512643-0	1993	Beta 1 and beta 4 integrin expression in methacarn and formalin-fixed material from in situ ductal carcinoma of the breast.	Formaldehyde	55-63	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	0-6
7512643-0	1993	Beta 1 and beta 4 integrin expression in methacarn and formalin-fixed material from in situ ductal carcinoma of the breast.	Formaldehyde	55-63	tubulin beta 3 class III	Homo sapiens	11-17
7512643-8	1993	This study demonstrates that two of the main beta chains, beta 1 and beta 4, can be effectively demonstrated on methacarn and cold (4 degrees C) formalin-fixed tissues by avidin-biotin indirect immunoperoxidase staining and that the results are similar to those achieved using frozen tissue.	Formaldehyde	145-153	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	58-64
7512643-8	1993	This study demonstrates that two of the main beta chains, beta 1 and beta 4, can be effectively demonstrated on methacarn and cold (4 degrees C) formalin-fixed tissues by avidin-biotin indirect immunoperoxidase staining and that the results are similar to those achieved using frozen tissue.	Formaldehyde	145-153	tubulin beta 3 class III	Homo sapiens	69-75
8121884-2	1993	Cathepsin D expression was immunohistochemically tested in 126 formalin-fixed and paraffin-embedded tissues from primary breast cancers.	Formaldehyde	63-71	cathepsin D	Homo sapiens	0-11
7901994-13	1993	We conclude that the immunohistochemical detection of p53 nuclear accumulation in formalin-fixed, paraffin-embedded tissue is highly associated with mutations in the p53 gene; this association has now been demonstrated in a large number of tumors.	Formaldehyde	82-90	tumor protein p53	Homo sapiens	54-57
7901994-13	1993	We conclude that the immunohistochemical detection of p53 nuclear accumulation in formalin-fixed, paraffin-embedded tissue is highly associated with mutations in the p53 gene; this association has now been demonstrated in a large number of tumors.	Formaldehyde	82-90	tumor protein p53	Homo sapiens	166-169
7692889-1	1993	OBJECTIVES: To improve the detection of p53 protein in formalin-fixed, paraffin-embedded head and neck tumor tissues.	Formaldehyde	55-63	tumor protein p53	Homo sapiens	40-43
7692889-8	1993	RESULTS: An antigen retrieval method facilitated the unmasking of previously inaccessible p53 antigenic determinants in formalin-fixed, paraffin-embedded tissues.	Formaldehyde	120-128	tumor protein p53	Homo sapiens	90-93
7692889-11	1993	CONCLUSIONS: Antigen retrieval method in formalin-fixed, paraffin-embedded tissue demonstrated a significant increase in p53 immunostaining.	Formaldehyde	41-49	tumor protein p53	Homo sapiens	121-124
8240292-0	1993	Stimulation by paraquat of microsomal and cytochrome P-450-dependent oxidation of glycerol to formaldehyde.	Formaldehyde	94-106	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	42-58
8240292-1	1993	Glycerol can be oxidized to formaldehyde by microsomes in a reaction that is dependent on cytochrome P-450.	Formaldehyde	28-40	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	90-106
8240292-11	1993	However, cytochrome P-450 is required for elevated rates of formaldehyde production even in the presence of paraquat.	Formaldehyde	60-72	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	9-25
8287627-10	1993	We conclude that synapsin I is a reliable, sensitive immunohistochemical marker for neuronal/neuroendocrine differentiation in human neoplasms and may offer some advantages over synaptophysin when applied to formalin-fixed, paraffin-embedded tissues, particularly in the evaluation of primitive neuroectodermal tumors and neuroendocrine tumors.	Formaldehyde	208-216	synapsin I	Homo sapiens	17-27
8252351-3	1993	Positive staining for p53 protein was detected in ten of 77 (13 per cent) of these tumours using polyclonal CM1 antibody on formalin-fixed tissue.	Formaldehyde	124-132	tumor protein p53	Homo sapiens	22-25
8288724-7	1993	When the M phi were replaced by T cell-depleted peripheral blood mononuclear cells (non-T cells), irradiated as well as formaldehyde fixed CLL cells were able to stimulate non-T cells to secrete IgE in the presence of IL-4 or to potentiate IL-4- and HC-induced IgE formation.	Formaldehyde	120-132	interleukin 4	Homo sapiens	218-222
8288724-7	1993	When the M phi were replaced by T cell-depleted peripheral blood mononuclear cells (non-T cells), irradiated as well as formaldehyde fixed CLL cells were able to stimulate non-T cells to secrete IgE in the presence of IL-4 or to potentiate IL-4- and HC-induced IgE formation.	Formaldehyde	120-132	interleukin 4	Homo sapiens	240-244
8254105-7	1993	These monoclonal antibodies to NSE are ideally suited for immunohistochemical studies and they should be particularly useful in histopathology as they react with epitopes which are resistant to formalin fixation and wax embedding.	Formaldehyde	194-202	enolase 2	Homo sapiens	31-34
8104689-8	1993	Importantly, a series of molecularly characterized breast cancer specimens were used to confirm that the antibody used was of sufficient sensitivity and specificity to identify those cancers overexpressing the HER-2/neu protein in this formalin-fixed, paraffin-embedded tissue cohort.	Formaldehyde	236-244	erb-b2 receptor tyrosine kinase 2	Homo sapiens	210-219
8105151-1	1993	The growth activity of 107 gastric carcinomas was assessed by immunohistochemical staining for formalin-fixed, paraffin-embedded tissue with a monoclonal antibody against proliferating cell nuclear antigen (PCNA).	Formaldehyde	95-103	proliferating cell nuclear antigen	Homo sapiens	207-211
7691930-0	1993	Antigen retrieval technique utilizing citrate buffer or urea solution for immunohistochemical demonstration of androgen receptor in formalin-fixed paraffin sections.	Formaldehyde	132-140	androgen receptor	Homo sapiens	111-128
7691930-1	1993	We developed a staining protocol for demonstration of androgen receptor (AR) in formalin-fixed, paraffin-embedded tissue sections.	Formaldehyde	80-88	androgen receptor	Homo sapiens	54-71
7691930-1	1993	We developed a staining protocol for demonstration of androgen receptor (AR) in formalin-fixed, paraffin-embedded tissue sections.	Formaldehyde	80-88	androgen receptor	Homo sapiens	73-75
7691930-6	1993	The antigen retrieval MW method can be used to demonstrate AR epitope in prostate tissue after fixation in formalin for as long as 7 days.	Formaldehyde	107-115	androgen receptor	Homo sapiens	59-61
7901825-1	1993	c-erbB-2 gene amplification was examined by slot blot hybridization using DNAs extracted from formalin-fixed and paraffin-embedded tissues of primary gastric carcinomas.	Formaldehyde	94-102	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-8
8280606-7	1993	Moreover, after pretreatment with the anti-fibrinogen antibody and fibrinogen, formalin-fixed platelets bound to fibrinogen saturably.	Formaldehyde	79-87	fibrinogen beta chain	Homo sapiens	43-53
8280606-7	1993	Moreover, after pretreatment with the anti-fibrinogen antibody and fibrinogen, formalin-fixed platelets bound to fibrinogen saturably.	Formaldehyde	79-87	fibrinogen beta chain	Homo sapiens	67-77
8397058-3	1993	RESULTS: C-erbB-2 protein was located on the cell membrane of cancer cells in formalin-fixed, paraffin-embedded sections.	Formaldehyde	78-86	erb-b2 receptor tyrosine kinase 2	Homo sapiens	9-17
8280606-7	1993	Moreover, after pretreatment with the anti-fibrinogen antibody and fibrinogen, formalin-fixed platelets bound to fibrinogen saturably.	Formaldehyde	79-87	fibrinogen beta chain	Homo sapiens	67-77
8212437-4	1993	To test these hypotheses, hsp-27 expression was evaluated by immunohistochemistry in archival formalin-fixed paraffin-embedded sections of primary prostate and bladder carcinomas where the outcome of the patient was known.	Formaldehyde	94-102	heat shock protein family B (small) member 1	Homo sapiens	26-32
8402645-13	1993	We conclude that analysis of methylation in the androgen receptor gene should allow study of clonality in most formalin-fixed, paraffin-embedded tissue specimens from women, including small preneoplastic lesions or rare conditions for which sufficient material is not available for analysis by other techniques.	Formaldehyde	111-119	androgen receptor	Homo sapiens	48-65
8406434-0	1993	Retrospective molecular detection of Transthyretin Met 111 mutation in a Danish kindred with familial amyloid cardiomyopathy, using DNA from formalin-fixed and paraffin-embedded tissues.	Formaldehyde	141-149	transthyretin	Homo sapiens	37-50
7506772-0	1993	Immunohistochemical detection of CD1A antigen in formalin-fixed and paraffin-embedded tissue sections with monoclonal antibody 010.	Formaldehyde	49-57	CD1a molecule	Homo sapiens	33-37
7506772-1	1993	The immunoreactivity of a CD1a monoclonal antibody (MAb), denoted 010, was investigated by means of the streptavidin-biotin-peroxidase method in formalin-fixed and paraffin-embedded tissues from 47 cases.	Formaldehyde	145-153	CD1a molecule	Homo sapiens	26-30
8232185-1	1993	The localization of Cu/Zn and Mn superoxide dismutase (SOD), which catalyzes the dismutation of superoxide radicals (O2-) to O2 and H2O2, in various thyroid disorders was studied by an immunohistochemical technique in 20% formalin fixed paraffin embedded thin sections using anti-human Cu/Zn and Mn-SOD antibodies.	Formaldehyde	222-230	superoxide dismutase 2	Homo sapiens	30-53
8232185-1	1993	The localization of Cu/Zn and Mn superoxide dismutase (SOD), which catalyzes the dismutation of superoxide radicals (O2-) to O2 and H2O2, in various thyroid disorders was studied by an immunohistochemical technique in 20% formalin fixed paraffin embedded thin sections using anti-human Cu/Zn and Mn-SOD antibodies.	Formaldehyde	222-230	superoxide dismutase 1	Homo sapiens	55-58
8168154-2	1993	With this technique, we have been able to detect expression of J chain and mu chain in a single 6-10-microns-thick formalin-fixed paraffin-embedded section of fetal liver tissue.	Formaldehyde	115-123	joining chain of multimeric IgA and IgM	Homo sapiens	63-83
8283348-6	1993	Overexpression of the p53 protein was found by immunostaining of sections from formalin-fixed, paraffin-embedded material in 55 per cent (51/92) of the tumours.	Formaldehyde	79-87	tumor protein p53	Homo sapiens	22-25
8283352-0	1993	Immunocytochemical p53 detection by microwave oven heating of routinely formalin-fixed paraffin sections.	Formaldehyde	72-80	tumor protein p53	Homo sapiens	19-22
7693495-0	1993	Antinociceptive effects in the formalin and capsaicin tests after intrathecal administration of substance P analogues in mice.	Formaldehyde	31-39	tachykinin 1	Mus musculus	96-107
7693495-4	1993	The early response induced by 0.0625% formalin was reduced significantly by the [D-His9]substance P and substance P-(6-11) analogues at 4.0 nmol, which were less potent than spantide.	Formaldehyde	38-46	tachykinin 1	Mus musculus	88-99
7506474-9	1993	Synaptophysin immunoreactivity, as demonstrated by SY-38, proved very sensitive to prolonged fixation and was of poor quality following formaldehyde and paraformaldehyde fixation.	Formaldehyde	136-148	synaptophysin	Homo sapiens	0-13
7693495-4	1993	The early response induced by 0.0625% formalin was reduced significantly by the [D-His9]substance P and substance P-(6-11) analogues at 4.0 nmol, which were less potent than spantide.	Formaldehyde	38-46	tachykinin 1	Mus musculus	104-115
8101229-5	1993	Using an immunoperoxidase technique, we stained archival formalin-fixed, paraffin-embedded tissue sections with a monoclonal antibody to the 185-kilodalton protein product (p185) of the HER-2/neu gene.	Formaldehyde	57-65	eukaryotic translation initiation factor 3 subunit A	Homo sapiens	173-177
8221069-1	1993	Subcutaneous formalin injection into the hindpaw of rats induces c-Fos expression in neurons in the ipsilateral spinal cord dorsal horn.	Formaldehyde	13-21	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	65-70
8222337-7	1993	Infusions of PTHrP (1 nmol/h), with or without 1 nmol bolus dose, significantly increased (P &lt; 0.05) urine osmolality (UOSM), but did not synergize with AVP in reducing CH2O.	Formaldehyde	172-176	parathyroid hormone like hormone	Homo sapiens	13-18
8359919-1	1993	The kinetics of tumor necrosis factor alpha (TNF-alpha) production, the correlation between cytokine levels and mortality rates after lethal challenge, and the production of a native inhibitor of TNF-alpha activity was investigated in mice immunized with formalin-killed Escherichia coli.	Formaldehyde	255-263	tumor necrosis factor	Mus musculus	196-205
8103785-2	1993	The results were as follows: 1) The immunohistochemical study of PCNA was useful as a marker to detect proliferating activity in formalin-fixed, paraffin-embedded tissue sections.	Formaldehyde	129-137	proliferating cell nuclear antigen	Homo sapiens	65-69
8105131-1	1993	Proliferating cell nuclear antigen (PCNA) of formalin-fixed, paraffin-embedded bladder cancer section was identified by immunohistochemistry in 42 bladder cancer patients.	Formaldehyde	45-53	proliferating cell nuclear antigen	Homo sapiens	0-34
8105131-1	1993	Proliferating cell nuclear antigen (PCNA) of formalin-fixed, paraffin-embedded bladder cancer section was identified by immunohistochemistry in 42 bladder cancer patients.	Formaldehyde	45-53	proliferating cell nuclear antigen	Homo sapiens	36-40
8236124-4	1993	An experiment with ADP-activated, formaldehyde-fixed platelets shows that platelets with activated fibrinogen receptors will bind inactive platelets in the presence of fibrinogen and Ca(2+)-ions.	Formaldehyde	34-46	fibrinogen beta chain	Homo sapiens	99-109
8236124-4	1993	An experiment with ADP-activated, formaldehyde-fixed platelets shows that platelets with activated fibrinogen receptors will bind inactive platelets in the presence of fibrinogen and Ca(2+)-ions.	Formaldehyde	34-46	fibrinogen beta chain	Homo sapiens	168-178
7507331-6	1993	Formalin-fixed, paraffin-embedded tissue sections are used to subsequently confirm the gene mutation by PCR amplification of the H-ras gene.	Formaldehyde	0-8	HRas proto-oncogene, GTPase	Homo sapiens	129-134
8101229-5	1993	Using an immunoperoxidase technique, we stained archival formalin-fixed, paraffin-embedded tissue sections with a monoclonal antibody to the 185-kilodalton protein product (p185) of the HER-2/neu gene.	Formaldehyde	57-65	erb-b2 receptor tyrosine kinase 2	Homo sapiens	186-195
8250729-0	1993	[Distribution of MCT and MCTC in nasal mucosae--relationship with formalin-sensitive mast cells and formalin-resistant mast cells].	Formaldehyde	66-74	solute carrier family 16 member 1	Homo sapiens	17-20
8342602-10	1993	These results demonstrate that primer-mediated, mutant-enriched polymerase chain reaction-restriction fragment length polymorphism analysis combined with allele-specific oligonucleotide hybridization can be used to detect and characterize mutations in codon 12 of the K-ras oncogene in formalin-fixed, paraffin-embedded tissues, and the results confirm that activating point mutations in codon 12 of the K-ras oncogene occur frequently in adenocarcinomas of the pancreas.	Formaldehyde	286-294	KRAS proto-oncogene, GTPase	Homo sapiens	268-273
8250729-0	1993	[Distribution of MCT and MCTC in nasal mucosae--relationship with formalin-sensitive mast cells and formalin-resistant mast cells].	Formaldehyde	100-108	solute carrier family 16 member 1	Homo sapiens	17-20
8409766-8	1993	To gain insight into changes in the tertiary structure of the mutant apoB, 13C-NMR analysis of LDL reductively methylated with [13C]-formaldehyde was performed.	Formaldehyde	133-145	apolipoprotein B	Sus scrofa	69-73
8347496-1	1993	The expression of p53 protein was immunohistochemically studied in formalin-fixed paraffin-embedded biopsy specimens of 203 colorectal carcinomas by use of a monoclonal antibody specific for the p53 protein.	Formaldehyde	67-75	tumor protein p53	Homo sapiens	18-21
7690737-3	1993	Anti-PCNA monoclonal antibody PC10 was applied to formalin-fixed, paraffin-embedded tissue using the avidin-biotin method.	Formaldehyde	50-58	proliferating cell nuclear antigen	Homo sapiens	5-9
8112175-1	1993	Expression of P53 protein was detected immunohistochemically in formalin-fixed, paraffin-embedded tissues from 67 patients with bladder carcinoma and 6 normal bladder controls.	Formaldehyde	64-72	tumor protein p53	Homo sapiens	14-17
8415813-6	1993	Statistical analysis of NAG, UBMG and CH2O demonstrated significant differences between both groups, in CH2O values at the third (P &lt; 0.05) and fifth days (P &lt; 0.05) after surgery, in NAG values at the fifty (P &lt; 0.01) and seventh days (P &lt; 0.01), and in UBMG values at the first (P &lt; 0.05) and third (P &lt; 0.05) postoperative day, respectively.	Formaldehyde	104-108	O-GlcNAcase	Homo sapiens	24-27
7692932-0	1993	Fixation with formaldehyde induces expression of activation dependent platelet membrane glycoproteins, P selectin (CD62) and GP53 (CD63).	Formaldehyde	14-26	selectin P	Homo sapiens	103-113
7692932-0	1993	Fixation with formaldehyde induces expression of activation dependent platelet membrane glycoproteins, P selectin (CD62) and GP53 (CD63).	Formaldehyde	14-26	selectin P	Homo sapiens	115-119
7692932-0	1993	Fixation with formaldehyde induces expression of activation dependent platelet membrane glycoproteins, P selectin (CD62) and GP53 (CD63).	Formaldehyde	14-26	CD63 molecule	Homo sapiens	131-135
7692932-7	1993	Formaldehyde increased the expression of both CD62 and CD63.	Formaldehyde	0-12	selectin P	Homo sapiens	46-50
7692932-7	1993	Formaldehyde increased the expression of both CD62 and CD63.	Formaldehyde	0-12	CD63 molecule	Homo sapiens	55-59
8331897-3	1993	EXPERIMENTAL DESIGN: We have developed an immunofluorescence in situ hybridization assay suitable for detection of MYCN amplification and 1p deletion in formalin-fixed, paraffin-embedded tissue sections.	Formaldehyde	153-161	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	115-119
8099533-6	1993	METHODS: The expression of c-erbB-2 protein was immunohistochemically investigated in the formaldehyde-fixed, paraffin-embedded tissues of 17 cases of IMHN, and 14 cases of pancreatic ductal cell carcinoma (8 cases with lymph node metastasis), using polyclonal and monoclonal c-erbB-2(p185) antibodies by the avidin-biotin method.	Formaldehyde	90-102	erb-b2 receptor tyrosine kinase 2	Homo sapiens	27-35
8415589-1	1993	The p53 gene was examined in a series of formalin-fixed paraffin-embedded astrocytic neoplasms of various types by polymerase chain reaction (PCR), single-strand conformation polymorphism analysis (SSCP), and direct sequencing of amplified DNA.	Formaldehyde	41-49	tumor protein p53	Homo sapiens	4-7
8415593-2	1993	The monoclonal antibodies KP1 (CD68), PG-M1 (CD68), and Ki-M1P can be used to detect normal and neoplastic monocytes/macrophages in formalin-fixed, paraffin-embedded tissue.	Formaldehyde	132-140	CD68 molecule	Homo sapiens	31-35
32370448-2	1993	In the present study, p53 immunoreactivity was investigated in formalin-fixed, paraffin-embedded tissues from human and animal pituitary tumors, using the avidin-biotin-peroxidase complex technique.	Formaldehyde	63-71	tumor protein p53	Homo sapiens	22-25
8265245-3	1993	Accurate and reliable determination of pS2 status in breast cancer can be made on the basis of immunohistochemistry using formalin fixed paraffin embedded sections.	Formaldehyde	122-130	taste 2 receptor member 64 pseudogene	Homo sapiens	39-42
8100680-4	1993	Proliferating cell nuclear antigen (PCNA), a protein associated with DNA polymerase that is expressed only in the nuclei of cells actively synthesizing DNA, was quantitated in 46 formalin-fixed, paraffin-embedded samples of various types of NHL using the Cell Analysis Systems 200 image analyzer.	Formaldehyde	179-187	proliferating cell nuclear antigen	Homo sapiens	0-34
8506952-4	1993	IgH gene rearrangements from a series of frozen or formalin-fixed B cell malignancies were PCR-amplified using oligonucleotide primers, based upon consensus sequences in the IgH variable and joining regions.	Formaldehyde	51-59	immunoglobulin heavy constant delta	Homo sapiens	0-3
8490902-0	1993	Immunocytochemical assay for estrogen receptor with monoclonal antibody D753P gamma in routinely processed formaldehyde-fixed breast tissue.	Formaldehyde	107-119	estrogen receptor 1	Homo sapiens	29-46
8335851-4	1993	RESULTS: An enzyme-linked immunosorbent assay showed that the worker had positive IgE and IgG titers to formaldehyde-human serum albumin.	Formaldehyde	104-116	albumin	Macaca mulatta	123-136
8335851-5	1993	The worker had a positive cutaneous test for formaldehyde-human serum albumin, and this cutaneous reactivity was transferred to a rhesus monkey through the worker"s serum.	Formaldehyde	45-57	albumin	Macaca mulatta	64-77
8103531-4	1993	For 77 melanocytic skin lesions, we compared PCNA immunostaining on formalin-fixed tissue with Ki-67 immunostaining on frozen material of the same lesion.	Formaldehyde	68-76	proliferating cell nuclear antigen	Homo sapiens	45-49
8486678-1	1993	The structures of formaldehyde-cross-linked adducts of daunorubicin-d(CG(araC)GCG) and doxorubicin-d(CA(araC)GTG) complexes at high resolution.	Formaldehyde	18-30	gamma-glutamyltransferase 1	Homo sapiens	109-112
8392521-3	1993	METHODS: The presence and localisation of the p53 protein in formalin fixed, paraffin wax embedded specimens of anal squamous epithelium (normal and neoplastic) was examined using immunohistochemical staining with a panel of two monoclonal antibodies (DO-1, DO-7) and one polyclonal antibody (CM-1).	Formaldehyde	61-69	tumor protein p53	Homo sapiens	46-49
8101959-5	1993	On the examination of fixation fluid, ethanol was considered to be more suitable than buffer formaldehyde because PCNA expressive rate in ethanol correlated to BrdU labeling index with statistical significance.	Formaldehyde	93-105	proliferating cell nuclear antigen	Homo sapiens	114-118
8347819-1	1993	The laminar distribution of spinal cord neurones expressing immunoreactivity to the Fos protein was evaluated in the rat following chemical, thermal or mechanical noxious stimulation of the skin for 2 h. After stimulation by 20% or 5% formalin, Fos-immunoreactive neurones prevailed in lamina I where they accounted for 64% and 59%, respectively, of the entire population of Fos-immunoreactive spinal cells.	Formaldehyde	235-243	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	84-87
8099452-11	1993	CONCLUSIONS: Because PCNA immunostaining can be done in routine formalin-fixed paraffin-embedded sections, this could be a powerful tool for providing information about the prognosis of patients with gastric cancer.	Formaldehyde	64-72	proliferating cell nuclear antigen	Homo sapiens	21-25
7684193-2	1993	Immunohistochemical staining with a monoclonal antibody (DO-7) and a polyclonal antibody (CM-1) to p53 protein (both wild type and mutant) on formalin-fixed paraffin sections showed a strong correlation with malignancy grade.	Formaldehyde	142-150	tumor protein p53	Homo sapiens	99-102
7684024-8	1993	In summary, PCNA staining of either B5- or formalin-fixed, paraffin-embedded tissue sections is a simple aid in the objective categorization of FCC lymphomas and may offer additional potentially prognostic information in some FCC subsets and in CC lymphomas.	Formaldehyde	43-51	proliferating cell nuclear antigen	Homo sapiens	12-16
8489386-2	1993	To achieve this goal, the presence and specific type of K-ras-2 point mutation was determined from formalin-fixed, paraffin-embedded tissue sites in 247 primary and 166 metastatic-recurrent colorectal adenocarcinomas, using a novel approach consisting of topographic tissue selection, DNA amplification, and direct sequencing applicable to large and needle-biopsy-sized specimens.	Formaldehyde	99-107	KRAS proto-oncogene, GTPase	Homo sapiens	56-63
8467460-2	1993	METHODS: Using a PTHrP-specific monoclonal antibody (MoAb), 4B3, the authors investigated the immunohistochemical localization of PTHrP in formalin-fixed and paraffin-embedded sections of normal human kidney tissues and tissues from 42 human renal cell carcinomas obtained at operation or autopsy.	Formaldehyde	139-147	parathyroid hormone like hormone	Homo sapiens	130-135
8100045-15	1993	However, in the medial thalamus, atipamezole produced a dramatic increase of formalin-induced c-FOS expression when compared with formalin injection alone.	Formaldehyde	77-85	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	94-99
7686566-6	1993	Formalin fixation reduced the percentage of carcinomas and cases of benign disease in which vimentin was detected.	Formaldehyde	0-8	vimentin	Homo sapiens	92-100
7686566-12	1993	CONCLUSION: There is some loss of vimentin immunoreactivity after formalin fixation.	Formaldehyde	66-74	vimentin	Homo sapiens	34-42
8468455-4	1993	In rat and mouse, IIB and IID fibers can be best distinguished according to their different mATPase stabilities towards formaldehyde and alkaline pH.	Formaldehyde	120-132	ATPase, class II, type 9B	Mus musculus	18-21
8468455-4	1993	In rat and mouse, IIB and IID fibers can be best distinguished according to their different mATPase stabilities towards formaldehyde and alkaline pH.	Formaldehyde	120-132	myosin, heavy polypeptide 1, skeletal muscle, adult	Mus musculus	26-29
8330803-4	1993	Formaldehyde caused a decrease of transaminase (GOT, GPT) in the medium and hepatocytes.	Formaldehyde	0-12	glutamic--pyruvic transaminase	Rattus norvegicus	53-56
7681701-1	1993	Two anti-nerve growth factor receptor (LNGFR or p75NGFR) antibodies, Me20.4 and Me8211, label stromal cells with dendritic features in fresh smears and in formalin-fixed, paraffin-embedded human bone marrow (BM).	Formaldehyde	155-163	nerve growth factor receptor	Homo sapiens	9-37
8330803-8	1993	All mixtures and formaldehyde inhibited GOT and GPT activity.	Formaldehyde	17-29	glutamic--pyruvic transaminase	Rattus norvegicus	48-51
8332552-2	1993	In the present study, Fos immunoreactivity was used as a marker of neuronal activity to investigate if subcutaneous injection of formalin (a model of noxious stimulation) could activate the CCKergic and dopaminergic neurons in the midbrain.	Formaldehyde	129-137	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	22-25
7681857-0	1993	Expression of the human progenitor cell antigen CD34 (HPCA-1) distinguishes dermatofibrosarcoma protuberans from fibrous histiocytoma in formalin-fixed, paraffin-embedded tissue.	Formaldehyde	137-145	CD34 molecule	Homo sapiens	48-52
8453672-10	1993	Interleukin-1 alpha (IL-1 alpha), tumor necrosis factor (TNF), and interleukin-6 (IL-6) were all secreted by mouse MNC after in vitro exposure to formalin-killed S. aureus.	Formaldehyde	146-154	interleukin 1 alpha	Mus musculus	0-19
8453672-10	1993	Interleukin-1 alpha (IL-1 alpha), tumor necrosis factor (TNF), and interleukin-6 (IL-6) were all secreted by mouse MNC after in vitro exposure to formalin-killed S. aureus.	Formaldehyde	146-154	interleukin 1 alpha	Mus musculus	21-31
8453672-10	1993	Interleukin-1 alpha (IL-1 alpha), tumor necrosis factor (TNF), and interleukin-6 (IL-6) were all secreted by mouse MNC after in vitro exposure to formalin-killed S. aureus.	Formaldehyde	146-154	tumor necrosis factor	Mus musculus	34-55
8453672-10	1993	Interleukin-1 alpha (IL-1 alpha), tumor necrosis factor (TNF), and interleukin-6 (IL-6) were all secreted by mouse MNC after in vitro exposure to formalin-killed S. aureus.	Formaldehyde	146-154	tumor necrosis factor	Mus musculus	57-60
8453672-10	1993	Interleukin-1 alpha (IL-1 alpha), tumor necrosis factor (TNF), and interleukin-6 (IL-6) were all secreted by mouse MNC after in vitro exposure to formalin-killed S. aureus.	Formaldehyde	146-154	interleukin 6	Mus musculus	67-80
8453672-10	1993	Interleukin-1 alpha (IL-1 alpha), tumor necrosis factor (TNF), and interleukin-6 (IL-6) were all secreted by mouse MNC after in vitro exposure to formalin-killed S. aureus.	Formaldehyde	146-154	interleukin 6	Mus musculus	82-86
8097999-2	1993	To establish more objective criteria, a monoclonal antibody to proliferating cell nuclear antigen (PCNA), PC10, which is a marker for proliferative activity of tumors, was applied to 21 myogenic tumors of the stomach (14 leiomyomas and 7 leiomyosarcomas) fixed in formalin.	Formaldehyde	264-272	proliferating cell nuclear antigen	Homo sapiens	63-97
7681857-3	1993	OBJECTIVE: This study is aimed at the introduction of a monoclonal antibody (anti-human progenitor cell antigen-1; anti-CD34) that distinguishes between DFSP and FH in formalin-fixed, paraffin-embedded tissue.	Formaldehyde	168-176	CD34 molecule	Homo sapiens	120-124
7687354-1	1993	Although over-expression of the C-erbB-2 oncogene product can be detected on formalin-fixed, paraffin-embedded sections from tumours of the human breast, fixation results in a considerable loss of immunostaining for this protein.	Formaldehyde	77-85	erb-b2 receptor tyrosine kinase 2	Homo sapiens	32-40
8100356-1	1993	In this retrospective study, 55 astrocytic tumours were stained with monoclonal antibody PC10 which recognizes the proliferating cell nuclear antigen (PCNA) in formalin fixed, paraffin-wax embedded sections.	Formaldehyde	160-168	proliferating cell nuclear antigen	Homo sapiens	115-149
8100356-1	1993	In this retrospective study, 55 astrocytic tumours were stained with monoclonal antibody PC10 which recognizes the proliferating cell nuclear antigen (PCNA) in formalin fixed, paraffin-wax embedded sections.	Formaldehyde	160-168	proliferating cell nuclear antigen	Homo sapiens	151-155
8094977-2	1993	The expression of c-erbB-2 oncoprotein was determined on formalin-fixed paraffin-embedded tissue, using a monoclonal anti-c-erbB-2 antibody by the avidin-biotin immunoperoxidase method.	Formaldehyde	57-65	erb-b2 receptor tyrosine kinase 2	Homo sapiens	18-26
8384406-1	1993	Striking differences were found between different histological types of breast cancer when 263 invasive breast carcinomas were tested for nuclear p53 accumulation in formaldehyde-fixed paraffin sections.	Formaldehyde	166-178	tumor protein p53	Homo sapiens	146-149
8384408-1	1993	The spectrum of p53 gene mutations was determined in formalin-fixed, paraffin-embedded samples of small-cell lung cancer derived from 28 patients.	Formaldehyde	53-61	tumor protein p53	Homo sapiens	16-19
8104720-1	1993	A monoclonal antibody, NCL-CB11, raised against a synthetic peptide from the predicted sequence of the c-erbB-2 protein has been used immunohistochemically in a retrospective study of formalin-fixed paraffin embedded breast neoplasm biopsies.	Formaldehyde	184-192	nucleolin	Homo sapiens	23-26
8104720-1	1993	A monoclonal antibody, NCL-CB11, raised against a synthetic peptide from the predicted sequence of the c-erbB-2 protein has been used immunohistochemically in a retrospective study of formalin-fixed paraffin embedded breast neoplasm biopsies.	Formaldehyde	184-192	erb-b2 receptor tyrosine kinase 2	Homo sapiens	103-111
8456936-2	1993	The polyclonal antibody used (CM-1) is directed against the wild-type p53 protein, but also recognizes the mutated p53 in formalin-fixed and paraffin-embedded sections.	Formaldehyde	122-130	tumor protein p53	Homo sapiens	115-118
8430685-0	1993	Resistance to erythropoietin: immunohemolytic anemia induced by residual formaldehyde in dialyzers.	Formaldehyde	73-85	erythropoietin	Homo sapiens	14-28
8433985-2	1993	Kinetic analysis with formaldehyde as substrate reveals that daidzin inhibits ALDH-I competitively with respect to formaldehyde with a Ki of 40 nM, and uncompetitively with respect to the coenzyme NAD+.	Formaldehyde	22-34	aldehyde dehydrogenase 2 family member	Homo sapiens	78-84
8433985-2	1993	Kinetic analysis with formaldehyde as substrate reveals that daidzin inhibits ALDH-I competitively with respect to formaldehyde with a Ki of 40 nM, and uncompetitively with respect to the coenzyme NAD+.	Formaldehyde	115-127	aldehyde dehydrogenase 2 family member	Homo sapiens	78-84
8438787-7	1993	These findings show that antibodies UCHL1, beta F1, and L26 can be used to determine the numbers of B and T lymphocytes in paraffin-embedded, formalin-fixed bone marrow specimens and thus may help to distinguish reactive T lymphocytosis from B-cell lymphoma.	Formaldehyde	142-150	ubiquitin C-terminal hydrolase L1	Homo sapiens	36-41
8438787-7	1993	These findings show that antibodies UCHL1, beta F1, and L26 can be used to determine the numbers of B and T lymphocytes in paraffin-embedded, formalin-fixed bone marrow specimens and thus may help to distinguish reactive T lymphocytosis from B-cell lymphoma.	Formaldehyde	142-150	ribosomal protein L26	Homo sapiens	56-59
7682680-6	1993	These results suggest that a negative control system, which is mediated by delta-opioid receptors and links substance P with somatostatin-mediated nociceptive transmission, may inhibit the formalin-induced second-phase of the nociceptive response in diabetic mice.	Formaldehyde	189-197	tachykinin 1	Mus musculus	108-119
8441227-7	1993	Pharmacological ANP levels raised CH2O and reduced UOsm.	Formaldehyde	34-38	natriuretic peptide A	Homo sapiens	16-19
8422109-1	1993	Expression of Proliferating cell nuclear antigen (PCNA) was evaluated in formalin-fixed, paraffin-embedded normal and abnormal cervical squamous epithelia using immunoperoxidase stains and PC10 monoclonal antibody to PCNA.	Formaldehyde	73-81	proliferating cell nuclear antigen	Homo sapiens	14-48
8422109-1	1993	Expression of Proliferating cell nuclear antigen (PCNA) was evaluated in formalin-fixed, paraffin-embedded normal and abnormal cervical squamous epithelia using immunoperoxidase stains and PC10 monoclonal antibody to PCNA.	Formaldehyde	73-81	proliferating cell nuclear antigen	Homo sapiens	50-54
8422109-6	1993	Proliferative activity can be satisfactorily assessed in formalin-fixed cervical epithelia using PC10 PCNA antibody.	Formaldehyde	57-65	proliferating cell nuclear antigen	Homo sapiens	102-106
8432919-0	1993	Immunohistochemical and immunoelectron microscopic demonstration of chromogranin A in formalin-fixed tissue of Merkel cell carcinoma.	Formaldehyde	86-94	chromogranin A	Homo sapiens	68-82
27314787-7	1993	The addition of H2O2 and catalase to the reaction system supplied molecular oxygen for methanol oxidation to formaldehyde by alcohol oxidase.	Formaldehyde	109-121	catalase	Homo sapiens	16-33
8422336-4	1993	We used a panel of specific antibodies to different lipoproteins and their apolipoprotein constituents, namely LDL, formaldehyde-fixed LDL, apolipoprotein B-100, HDL, and formaldehyde-fixed apolipoprotein A-I.	Formaldehyde	171-183	apolipoprotein A1	Homo sapiens	190-208
8093216-1	1993	An immunohistochemical study of the c-erbB-2 protein was conducted on formalin-fixed paraffin-embedded tissue sections from 136 primary gastric carcinomas and 50 metastatic lymph-node tumors obtained at gastrectomy.	Formaldehyde	70-78	erb-b2 receptor tyrosine kinase 2	Homo sapiens	36-44
7678022-1	1993	Proliferating cell nuclear antigen (PCNA) was evaluated as a marker of cell proliferation in formalin-fixed rat liver tissue through a comparative study with the thymidine analogue 5-bromo-2"-deoxyuridine (BrdU).	Formaldehyde	93-101	proliferating cell nuclear antigen	Rattus norvegicus	0-41
8358113-4	1993	nm23 gene product, which shows complete identity to human erythrocyte nucleoside diphosphate kinase, was used to raise an affinity-purified polyclonal antibody Ab-11 which is applicable to formalin-fixed and paraffin-embedded tissues.	Formaldehyde	189-197	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	0-4
8104445-6	1993	PCNA immunostaining after formaldehyde fixation thus appears as a valid approach for mapping the proliferative compartment and demonstrating tumour heterogeneity or abnormalities in the distribution of proliferative cells.	Formaldehyde	26-38	proliferating cell nuclear antigen	Homo sapiens	0-4
8400325-1	1993	The expression of cathepsin D was evaluated by immunohistochemistry on histologic sections from formalin-fixed samples in a series of 436 primary breast cancers.	Formaldehyde	96-104	cathepsin D	Homo sapiens	18-29
8093255-3	1993	The difficulties associated with the hitherto unsuccessful application of PCNA immunocytochemical methods to tissues fixed in formalin for BrdU visualization were overcome by epitope unmasking with acid hydrolysis, extension of primary antiserum (PC10) incubation, and employment of streptavidin-ABC-HRP.	Formaldehyde	126-134	proliferating cell nuclear antigen	Homo sapiens	74-78
8094884-1	1993	We studied the overexpression of c-erbB-2 protein in formalin-fixed, paraffin-embedded tissues from matched primary tumors and metastatic lymph nodes derived from each of 95 breast carcinoma patients.	Formaldehyde	53-61	erb-b2 receptor tyrosine kinase 2	Homo sapiens	33-41
8449825-0	1993	bcl-2 gene rearrangement analysis of Japanese follicular lymphomas by polymerase chain reaction in formalin-fixed, paraffin-embedded tissue specimens.	Formaldehyde	99-107	BCL2 apoptosis regulator	Homo sapiens	0-5
7509541-1	1993	Overexpression of p53 and erbB-2 was studied by immunohistochemistry in formalin-fixed tissue samples of 179 patients with transitional cell carcinoma of the urinary bladder.	Formaldehyde	72-80	tumor protein p53	Homo sapiens	18-21
7902557-4	1993	The data indicate that PCNA can be detected in formalin-fixed tissues by either classic immunohistochemical analysis or by flow cytometry.	Formaldehyde	47-55	proliferating cell nuclear antigen	Homo sapiens	23-27
7681206-8	1993	The pattern of PCNA staining in formalin fixed specimens was widely variable, probably due to differences in preservation of antigen.	Formaldehyde	32-40	proliferating cell nuclear antigen	Homo sapiens	15-19
7687782-1	1993	Transforming growth factor alpha (TGF alpha) expression was analyzed immunocytochemically on formalin-fixed wax-embedded sections obtained from 24 benign prostatic hyperplasia (BPH) specimens and 76 prostatic carcinoma tissues, 3 human prostatic tumor xenografts, normal kidney, and salivary gland.	Formaldehyde	93-101	transforming growth factor alpha	Homo sapiens	34-43
8236825-0	1993	Epidermal growth factor receptor expression in squamous cell lung carcinomas: an immunohistochemical and gene analysis in formalin-fixed, paraffin-embedded material.	Formaldehyde	122-130	epidermal growth factor receptor	Homo sapiens	0-32
7505056-3	1993	Using a monoclonal antibody, AB-3, which recognizes -COOH-terminal of neu oncoprotein, we have analyzed immunohistochemically the expression of this protein in buffered formalin and Zamboni fluid-fixed surgically removed tissues.	Formaldehyde	169-177	erb-b2 receptor tyrosine kinase 2	Homo sapiens	70-73
8506620-2	1993	Using a microwave oven heating method, we have detected over-expression of p53 in buffered-formalin fixed, paraffin-embedded sections of oesophageal carcinomas immunohistochemically and examined the relationship between the p53 over-expression and postoperative survival.	Formaldehyde	91-99	tumor protein p53	Homo sapiens	75-78
8236825-2	1993	We evaluated the expression of EGFr and examined possible EGFr gene alterations in 18 formalin-fixed, paraffin-embedded squamous cell lung carcinomas (SCLC) by an immunohistochemical assay, Southern blotting and differential polymerase chain reaction (DPCR).	Formaldehyde	86-94	epidermal growth factor receptor	Homo sapiens	58-62
7509541-1	1993	Overexpression of p53 and erbB-2 was studied by immunohistochemistry in formalin-fixed tissue samples of 179 patients with transitional cell carcinoma of the urinary bladder.	Formaldehyde	72-80	erb-b2 receptor tyrosine kinase 2	Homo sapiens	26-32
7902171-3	1993	In formalin-fixed tissues, the PCNA staining pattern, which should be confined to replicon units in the nucleus, was optimized by 1 h postfixation in an organic solvent (methacarn).	Formaldehyde	3-11	proliferating cell nuclear antigen	Homo sapiens	31-35
7906909-1	1993	The expression of proliferating cell nuclear antigen (PCNA) was examined in formalin-fixed paraffin-embedded tissue sections from 41 lesions (27 melanocytic nevi, 3 atypical nevi and 11 malignant melanomas) to determine the proliferative activity of primary cutaneous melanocytic tumours.	Formaldehyde	76-84	proliferating cell nuclear antigen	Homo sapiens	18-52
7906909-1	1993	The expression of proliferating cell nuclear antigen (PCNA) was examined in formalin-fixed paraffin-embedded tissue sections from 41 lesions (27 melanocytic nevi, 3 atypical nevi and 11 malignant melanomas) to determine the proliferative activity of primary cutaneous melanocytic tumours.	Formaldehyde	76-84	proliferating cell nuclear antigen	Homo sapiens	54-58
1453005-3	1992	This enzyme has a low activity with ethanol, is specific for the glutathione-dependent oxidation of formaldehyde, and is therefore a formaldehyde dehydrogenase (FALDH).	Formaldehyde	100-112	alcohol dehydrogenase 5 (class III), chi polypeptide	Rattus norvegicus	133-159
1447200-6	1992	Monomeric native bovine serum albumin (BSA) interacted much less avidly than A-Au and BSA that was chemically modified by formaldehyde (Fm-BSA) or maleic anhydride (Mal-BSA).	Formaldehyde	122-134	albumin	Rattus norvegicus	24-37
1361306-1	1992	Results generated by the immunohistochemical staining with PC10, a new monoclonal antibody recognizing PCNA (a nuclear protein associated with cell proliferation) in formalin-fixed and paraffin-embedded tissue were compared with those of Ki-67 labeling and DNA flow cytometry in 47 consecutive non-small cell lung cancer (NSCLC).	Formaldehyde	166-174	proliferating cell nuclear antigen	Homo sapiens	103-107
1361306-6	1992	Results indicate that PCNA labeling with PC10 is a simple method for assessing the proliferative activity in formalin-fixed, paraffin-embedded tissue of NSCLC and correlates well with Ki-67 labeling and S-phase fraction of the cell cycle.	Formaldehyde	109-117	proliferating cell nuclear antigen	Homo sapiens	22-26
1283171-2	1992	Antibodies LL001, LL003, BA17, LP34, CAM5.2, and LH1 were found to be reactive in formalin-fixed material and were used to study 23 basal cell carcinomas, 8 squamous cell carcinomas, 5 keratoacanthomas, 5 Bowen"s disease, and 6 clear cell acanthomas.	Formaldehyde	82-90	procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	Homo sapiens	49-52
1339376-1	1992	A gene (FDH1) of Candida maltosa which confers resistance to formaldehyde in Saccharomyces cerevisiae was cloned and its nucleotide sequence determined.	Formaldehyde	61-73	formate dehydrogenase (NAD+)	Saccharomyces cerevisiae S288C	8-12
1487569-1	1992	A histochemical investigation of lectin-binding sites was carried out on formalin-fixed paraffin-embedded sections of 60 skin appendage tumors and adjacent normal skin appendages, using four different biotinylated lectins, peanut agglutinin (PNA), Dolichos biflorus agglutinin (DBA), soybean agglutinin (SBA), and Ulex europaeus agglutinin-1 (UEA-1), and avidin-biotin-horseradish peroxidase labeling.	Formaldehyde	73-81	LOW QUALITY PROTEIN: lectin	Glycine max	33-39
1453005-3	1992	This enzyme has a low activity with ethanol, is specific for the glutathione-dependent oxidation of formaldehyde, and is therefore a formaldehyde dehydrogenase (FALDH).	Formaldehyde	100-112	alcohol dehydrogenase 5 (class III), chi polypeptide	Rattus norvegicus	161-166
1453005-11	1992	We propose that one of the functions of FALDH is to protect cell structures, including DNA, from the toxic effects of endogenous formaldehyde, which is an intermediate in many metabolic process.	Formaldehyde	129-141	alcohol dehydrogenase 5 (class III), chi polypeptide	Rattus norvegicus	40-45
1424288-6	1992	IL-4-induced IgE synthesis was also obtained in co-cultures of formaldehyde-fixed T cells with non-T cells.	Formaldehyde	63-75	interleukin 4	Homo sapiens	0-4
1484317-0	1992	Monoclonal antibodies against recombinant parts of the Ki-67 antigen (MIB 1 and MIB 3) detect proliferating cells in microwave-processed formalin-fixed paraffin sections.	Formaldehyde	137-145	MIB E3 ubiquitin protein ligase 1	Homo sapiens	55-85
1484317-6	1992	However, when dewaxed microwave oven-processed paraffin sections of formalin-fixed tissues were used, MIB 1 and MIB 3 gave strong nuclear staining of those cells presumed to proliferate under a variety of normal and neoplastic conditions.	Formaldehyde	68-76	MIB E3 ubiquitin protein ligase 1	Homo sapiens	102-107
1484319-0	1992	p53 immunostaining in the distinction between benign and malignant mesothelial proliferations using formalin-fixed paraffin sections.	Formaldehyde	100-108	tumor protein p53	Homo sapiens	0-3
1484319-2	1992	The object of this study was to examine the frequency of immunohistochemically detectable p53 overexpression in routinely processed, paraffin-embedded tissue from pleural mesotheliomas and from pleura showing reactive mesothelial hyperplasia, using a polyclonal antibody to formalin-resistant p53 epitopes, and to consider the diagnostic utility of this antibody in the distinction between mesothelioma and reactive mesothelium in pleural biopsy specimens.	Formaldehyde	274-282	tumor protein p53	Homo sapiens	90-93
1484319-6	1992	In conclusion, this study suggests that p53 immunostaining can help to distinguish epithelial or biphasic mesothelioma from reactive mesothelial hyperplasia in formalin-fixed, paraffin-embedded pleural biopsy specimens.	Formaldehyde	160-168	tumor protein p53	Homo sapiens	40-43
1358427-4	1992	METHODS: Immunohistologic study of the c-erbB-2 gene product was done in formaldehyde-fixed paraffin-embedded tissue specimens obtained from 88 transitional cell carcinomas of the human urinary bladder.	Formaldehyde	73-85	erb-b2 receptor tyrosine kinase 2	Homo sapiens	39-47
1394239-0	1992	p53 mutations in formaldehyde-induced nasal squamous cell carcinomas in rats.	Formaldehyde	17-29	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	0-3
1394239-2	1992	We have examined the complementary DNA of the tumor suppressor gene p53 from 11 primary formaldehyde-induced tumors for mutation using DNA sequence analysis.	Formaldehyde	88-100	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	68-71
1394239-5	1992	These data demonstrate p53 point mutations in formaldehyde-induced squamous cell carcinomas and indicate a common alteration in certain rat and human squamous cell carcinomas of the respiratory tract.	Formaldehyde	46-58	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	23-26
1460656-5	1992	Treatment of gal-FnBP with formalin inactivated the binding capacity of the protein but immunogenicity was retained.	Formaldehyde	27-35	AT695_RS04805	Staphylococcus aureus	17-21
1460656-6	1992	Immunisation of mice with formalin-treated gal-FnBP resulted in high antibody titres against the fibronectin-binding part of this fusion protein.	Formaldehyde	26-34	AT695_RS04805	Staphylococcus aureus	47-51
1460656-6	1992	Immunisation of mice with formalin-treated gal-FnBP resulted in high antibody titres against the fibronectin-binding part of this fusion protein.	Formaldehyde	26-34	fibronectin 1	Mus musculus	97-108
1460656-8	1992	Sera raised against formalin-treated gal-FnBP and non-treated gal-FnBP blocked this binding to 40 and 25% respectively, thereby indicating the usefulness of gal-FnBP as a vaccine component.	Formaldehyde	20-28	AT695_RS04805	Staphylococcus aureus	41-45
1433525-0	1992	Pulmonary histopathology induced by respiratory syncytial virus (RSV) challenge of formalin-inactivated RSV-immunized BALB/c mice is abrogated by depletion of CD4+ T cells.	Formaldehyde	83-91	CD4 antigen	Mus musculus	159-162
1361755-2	1992	Proliferative cell nuclear antigen (PCNA) expression was analyzed in formalin-fixed and paraffin-embedded specimens from patients with urinary bladder cancer using three different anti-PCNA monoclonal antibodies.	Formaldehyde	69-77	proliferating cell nuclear antigen	Homo sapiens	36-40
1358781-3	1992	Immunoreactive p53 was observed in the nuclei of tumor cells in 4% paraformaldehyde-fixed, frozen sections (12 of 15) and paraffin-embedded sections (11 of 15), but not in routinely processed (10% formalin-fixed) specimens.	Formaldehyde	197-205	tumor protein p53	Homo sapiens	15-18
1427749-3	1992	We have studied the expression of this protein in different subtypes of Hodgkin"s disease using monoclonal antibodies directed against a formalin-resistant epitope of the bcl-2 protein and also have investigated these cases by polymerase chain reaction for evidence of the t(14;18) translocation.	Formaldehyde	137-145	BCL2 apoptosis regulator	Homo sapiens	171-176
1430099-6	1992	In cultured fibroblasts capping of surface GH receptor was observed after aqueous formaldehyde fixation, whereas fixation in Carnoy"s solution resulted in granular cytoplasmic staining.	Formaldehyde	82-94	growth hormone receptor	Homo sapiens	43-54
1285443-12	1992	Its pattern of expression seems similar to CD5; however, unlike CD5, CD43 can be studied in formalin-fixed tissue.	Formaldehyde	92-100	sialophorin	Homo sapiens	69-73
1361526-4	1992	Expression of c-erbB-3 protein was indicated by membrane and/or cytoplasmic tumour cell immunoreactivity in formalin-fixed, paraffin-embedded tissue sections.	Formaldehyde	108-116	erb-b2 receptor tyrosine kinase 3	Homo sapiens	14-22
1384306-2	1992	Expression of K-19 was evaluated by immunoperoxidase staining in formalin-fixed normal ectocervical tissue, normal endocervical tissue, cervical dysplasia, squamous metaplasia, atrophic epithelium, cervical condylomas, and invasive carcinoma to determine if a correlation of K-19 expression with dysplasia was present in the cervical epithelium.	Formaldehyde	65-73	keratin 19	Homo sapiens	14-18
1443417-3	1992	Rates of hydrogen peroxide production, assessed from the oxidation of methanol to formaldehyde by catalase-H2O2, were similar in tissue cylinders isolated from periportal regions in control and ethanol-treated rats.	Formaldehyde	82-94	catalase	Rattus norvegicus	98-106
1283010-0	1992	Intrathecal co-administration of substance P and NMDA augments nociceptive responses in the formalin test.	Formaldehyde	92-100	tachykinin 1	Mus musculus	33-44
1283010-1	1992	The effects of intrathecal administration of substance P and N-methyl-D-aspartate (NMDA) were studied in the formalin test in mice.	Formaldehyde	109-117	tachykinin 1	Mus musculus	45-56
1283010-3	1992	Co-administration of substance P and NMDA intensified the response in both the 1st (0-10 min) and the 2nd phase (20-30 min) of the formalin test, and increased the duration of the response.	Formaldehyde	131-139	tachykinin 1	Mus musculus	21-32
1524418-7	1992	Oxidation of 1,2-propanediol to formaldehyde plus acetaldehyde involved interaction with an oxidant derived from H2O2 plus nonheme iron, since production of the two aldehydic products was completely prevented by catalase or glutathione plus glutathione peroxidase and by chelators such as desferrioxamine or EDTA.	Formaldehyde	32-44	catalase	Rattus norvegicus	212-220
1358045-3	1992	The present study evaluates c-erbB-2 protein over-production in sarcomas and in small round-cell tumors of childhood by applying an immunohistochemical technique to formalin-fixed, paraffin-embedded tissues.	Formaldehyde	165-173	erb-b2 receptor tyrosine kinase 2	Homo sapiens	28-36
1423854-2	1992	A range of lesions from the livers were analysed for the presence of mutations in the Ha-ras proto-oncogene at codon 61 using the polymerase chain reaction to amplify DNA from formalin-fixed sections, followed by oligonucleotide hybridization.	Formaldehyde	176-184	Harvey rat sarcoma virus oncogene	Mus musculus	86-92
21584586-1	1992	The immunoreactivity of monoclonal anti-neuron-specific enolase (MoAb NSE) on 10% formalin-fixed sections of normal human salivary glands and tumors were examined by the avidin-biotin-peroxidase complex (ABC) method.	Formaldehyde	82-90	enolase 2	Homo sapiens	70-73
1356909-1	1992	Commercially available monoclonal antibodies were tested for their ability to detect increased levels of c-erbB-2 protein in formalin-fixed, paraffin-embedded breast carcinomas.	Formaldehyde	125-133	erb-b2 receptor tyrosine kinase 2	Homo sapiens	105-113
1416377-3	1992	Immunoreactive EGF (IR-EGF) and EGF receptors (EGF-R) were histochemically identified in formalin-fixed tissues of the upper digestive tract of 1-, 3-, 7-, 14-, 21-, and 28-day-old pigs.	Formaldehyde	89-97	epidermal growth factor	Sus scrofa	15-26
1355398-12	1992	It was concluded that PCNA immunostaining is a simple and clinically useful method for estimating cell proliferation in formalin-fixed, paraffin-embedded tissue of resected peripheral, node-negative NSCLC.	Formaldehyde	120-128	proliferating cell nuclear antigen	Homo sapiens	22-26
1416377-3	1992	Immunoreactive EGF (IR-EGF) and EGF receptors (EGF-R) were histochemically identified in formalin-fixed tissues of the upper digestive tract of 1-, 3-, 7-, 14-, 21-, and 28-day-old pigs.	Formaldehyde	89-97	epidermal growth factor	Sus scrofa	15-18
1354677-2	1992	Our goal was to provide guidelines for PCNA immunohistochemistry in formalin-fixed, paraffin-embedded specimens.	Formaldehyde	68-76	proliferating cell nuclear antigen	Homo sapiens	39-43
1505911-1	1992	The localization of the expression of several cytochrome P-450 genes in normal and diseased human liver was investigated by in situ hybridization of formalin-fixed, paraffin wax-embedded archival tissue samples with 35S-labeled antisense RNA probes.	Formaldehyde	149-157	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	46-62
1285276-6	1992	IHC and ISH analyses showed that all cases were positive for gastrin protein and 24 of 25 (96%) expressed gastrin mRNA that was easily detected in formalin-fixed, paraffin-embedded tissue sections.	Formaldehyde	147-155	gastrin	Homo sapiens	106-113
1354677-9	1992	With all three antibodies, however, PCNA immunoreactivity was well preserved during formalin fixation for 8-24 hr and during fixation delays for 8 hr at room temperature.	Formaldehyde	84-92	proliferating cell nuclear antigen	Homo sapiens	36-40
1388034-5	1992	It seems likely that this activity is connected with binding to Fn molecules since formalin inactivation of FnBP (60%) abolished it.	Formaldehyde	83-91	AT695_RS04805	Staphylococcus aureus	108-112
1363339-2	1992	Recently, a monoclonal antibody against the proliferating cell nuclear antigen (PCNA or cyclin), a nuclear protein expressed in proliferating cells, was developed which could be used on formalin fixed, paraffin embedded tissue.	Formaldehyde	186-194	proliferating cell nuclear antigen	Homo sapiens	44-78
1363339-2	1992	Recently, a monoclonal antibody against the proliferating cell nuclear antigen (PCNA or cyclin), a nuclear protein expressed in proliferating cells, was developed which could be used on formalin fixed, paraffin embedded tissue.	Formaldehyde	186-194	proliferating cell nuclear antigen	Homo sapiens	80-84
1363339-2	1992	Recently, a monoclonal antibody against the proliferating cell nuclear antigen (PCNA or cyclin), a nuclear protein expressed in proliferating cells, was developed which could be used on formalin fixed, paraffin embedded tissue.	Formaldehyde	186-194	proliferating cell nuclear antigen	Homo sapiens	88-94
1425772-6	1992	A major part of hsp90 immunoreactivity was diffusely distributed throughout the interphase cytoplasm, but a weak nuclear staining with non-stained nucleoli was also present, however, only detectable after methanol and not after formaldehyde/Triton X-100 fixation.	Formaldehyde	228-240	heat shock protein 90 alpha family class A member 1	Homo sapiens	16-21
1322859-2	1992	We applied immunohistochemistry using the avidin-biotin-peroxidase technique to localize PLP in formalin-fixed, paraffin-embedded tissues of two human pancreatic carcinomas associated with hypercalcemia and normal blood parathyroid hormone levels.	Formaldehyde	96-104	parathyroid hormone like hormone	Homo sapiens	89-92
1639159-5	1992	When formaldehyde-fixed epimastigotes were used as antigen, binding of IgG1 and IgG2 was observed.	Formaldehyde	5-17	LOC105243590	Mus musculus	71-75
1639487-3	1992	Our data showed that whole formalin-fixed heat-killed P. aeruginosa was mitogenic for human lymphocytes and induced production of substantial amounts of tumor necrosis factor alpha (TNF) in peripheral blood mononuclear leukocytes in cultures.	Formaldehyde	27-35	tumor necrosis factor	Homo sapiens	153-180
1639487-3	1992	Our data showed that whole formalin-fixed heat-killed P. aeruginosa was mitogenic for human lymphocytes and induced production of substantial amounts of tumor necrosis factor alpha (TNF) in peripheral blood mononuclear leukocytes in cultures.	Formaldehyde	27-35	tumor necrosis factor	Homo sapiens	182-185
1639855-13	1992	To study the expression of AR in human colon in vivo, AR was localized immunocytochemically in formalin-fixed, paraffin-embedded sections from normal and malignant human colon using the AR-Ab1 antibodies.	Formaldehyde	95-103	amphiregulin	Homo sapiens	54-56
1401176-2	1992	METHODS: alpha and pi class GST were immunolocalised in sections of formalin fixed liver tissue obtained from human fetuses (n = 21), neonates (n = 8), young children (n = 9) and adults (n = 10), and from neonates with extrahepatic biliary atresia (n = 15) and neonatal hepatitis (n = 12).	Formaldehyde	68-76	glutathione S-transferase kappa 1	Homo sapiens	28-31
1639855-13	1992	To study the expression of AR in human colon in vivo, AR was localized immunocytochemically in formalin-fixed, paraffin-embedded sections from normal and malignant human colon using the AR-Ab1 antibodies.	Formaldehyde	95-103	amphiregulin	Homo sapiens	54-56
1293753-6	1992	The c-fos expression was very low in control animals receiving neither formalin nor EA administration.	Formaldehyde	71-79	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	4-9
1279244-8	1992	Additionally, we showed the applicability of immunohistochemical detection of p53 protein in endoscopic biopsy material routinely formalin-fixed.	Formaldehyde	130-138	tumor protein p53	Homo sapiens	78-81
1636730-2	1992	Immunoperoxidase studies of formaldehyde solution-fixed and paraffin-embedded rat lung demonstrated staining for SP-D in the cytoplasm of a subpopulation of bronchiolar epithelial cells as well as type II cells.	Formaldehyde	28-40	surfactant protein D	Rattus norvegicus	113-117
1319835-9	1992	Also, carcinoma cells with p53 mutations existing within adenoma tissues are detectable by immunostaining, even in formalin-fixed, paraffin-embedded specimens.	Formaldehyde	115-123	tumor protein p53	Homo sapiens	27-30
1615913-6	1992	It is concluded that quantitative immunocytochemical results for estrogen and progesterone receptor content in formalin-fixed, paraffin-embedded tissue can be generated using image analysis.	Formaldehyde	111-119	progesterone receptor	Homo sapiens	78-99
1607637-0	1992	p53 overexpression in formalin-fixed, paraffin-embedded tissue detected by immunohistochemistry.	Formaldehyde	22-30	tumor protein p53	Homo sapiens	0-3
1341005-0	1992	Detection of estrogen receptor in formalin-fixed and paraffin-embedded breast carcinoma: correlation with histological patterns.	Formaldehyde	34-42	estrogen receptor 1	Homo sapiens	13-30
1303503-5	1992	Noxious stimuli such as electrical C-fibre stimulation, noxious skin heating or subcutaneous formalin injection result in the transsynaptic induction of the IEG encoded proteins c-Fos, C-Jun and Krox-24, in the dorsal horn of the spinal cord.	Formaldehyde	93-101	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	178-183
1303503-5	1992	Noxious stimuli such as electrical C-fibre stimulation, noxious skin heating or subcutaneous formalin injection result in the transsynaptic induction of the IEG encoded proteins c-Fos, C-Jun and Krox-24, in the dorsal horn of the spinal cord.	Formaldehyde	93-101	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	185-190
1303503-5	1992	Noxious stimuli such as electrical C-fibre stimulation, noxious skin heating or subcutaneous formalin injection result in the transsynaptic induction of the IEG encoded proteins c-Fos, C-Jun and Krox-24, in the dorsal horn of the spinal cord.	Formaldehyde	93-101	early growth response 1	Homo sapiens	195-202
1341005-1	1992	The authors studied the expression of estrogen receptor (ER) in tissues of breast carcinomas which were previously fixed in formalin and paraffin-embedded.	Formaldehyde	124-132	estrogen receptor 1	Homo sapiens	38-55
1341005-1	1992	The authors studied the expression of estrogen receptor (ER) in tissues of breast carcinomas which were previously fixed in formalin and paraffin-embedded.	Formaldehyde	124-132	estrogen receptor 1	Homo sapiens	57-59
1597154-5	1992	Immunofluorescent labeling of the GR in formaldehyde-fixed and detergent-permeabilized cells resulted in the almost complete absence of immunoreactivity of cells when the receptor was in its unliganded form, whereas the liganded receptor was detected mainly in the nucleus.	Formaldehyde	40-52	nuclear receptor subfamily 3 group C member 1	Homo sapiens	34-36
1317462-3	1992	METHODS: IgG1 monoclonal antibody to human p53 protein (PAb 1801) and immunohistochemical methods were used to detect p53 protein accumulation in archival formalin-fixed, paraffin-embedded, randomly selected carcinomas.	Formaldehyde	155-163	tumor protein p53	Homo sapiens	118-121
1374778-6	1992	However the expression of CD11b, CD16 and CDw32 was significantly higher (p less than 0.05) on neutrophils obtained by dextran sedimentation (n = 4) than on cells which had been fixed with formaldehyde ex vivo; the increase in expression was even greater if the cells had been washed.	Formaldehyde	189-201	integrin subunit alpha M	Homo sapiens	26-31
1622111-5	1992	The effect of formalin fixation of c-myc expression was simultaneously studied.	Formaldehyde	14-22	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	35-40
1622111-7	1992	Only two samples fixed in formalin showed positive signals for c-myc mRNA.	Formaldehyde	26-34	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	63-68
1349455-0	1992	Proliferating cell nuclear antigen counts in formalin-fixed paraffin-embedded tissue correlate with Ki-67 in fresh tissue.	Formaldehyde	45-53	proliferating cell nuclear antigen	Homo sapiens	0-34
1349455-6	1992	Proliferating cell nuclear antigen positivity was easier to evaluate because morphology was better preserved in formalin-fixed tissue.	Formaldehyde	112-120	proliferating cell nuclear antigen	Homo sapiens	0-34
1374778-6	1992	However the expression of CD11b, CD16 and CDw32 was significantly higher (p less than 0.05) on neutrophils obtained by dextran sedimentation (n = 4) than on cells which had been fixed with formaldehyde ex vivo; the increase in expression was even greater if the cells had been washed.	Formaldehyde	189-201	Fc gamma receptor IIc (gene/pseudogene)	Homo sapiens	42-47
1374778-7	1992	In contrast, the expression of CD13 on formaldehyde fixed cells was higher than on cells which had been labelled at 4 degrees C or at room temperature and was similar to or slightly lower than that on cells obtained by dextran sedimentation.	Formaldehyde	39-51	alanyl aminopeptidase, membrane	Homo sapiens	31-35
1511275-0	1992	Fos-like immunoreactivity in the rat superficial dorsal horn induced by formalin injection in the forepaw: effects of dorsal rhizotomies.	Formaldehyde	72-80	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-3
1511275-1	1992	As previously described at the lumbar spinal level, we found that 2 h after subcutaneous formalin injection in the distal part of the fore-limb, Fos-like immunoreactivity (FLI) was induced in the ipsilateral cervical enlargement.	Formaldehyde	89-97	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	145-148
1315214-3	1992	Moreover, no sex-differences were encountered in the NGFr immunoreaction intensity and Bouin fixative was more effective than 10% formaldehyde evidenciating the NGFr immunostain.	Formaldehyde	130-142	nerve growth factor receptor	Rattus norvegicus	161-165
1373272-2	1992	Using the hydrated autoclaving method, a new immunohistochemical procedure to enhance tau immunoreactivity in formalin-fixed brain tissue, the authors recently reported that tau protein is detected in neuronal cell bodies and proximal dendrites, gray matter neuropil, axons, and glial cells in normal human hippocampus and neocortex.	Formaldehyde	110-118	microtubule associated protein tau	Homo sapiens	86-89
1373272-2	1992	Using the hydrated autoclaving method, a new immunohistochemical procedure to enhance tau immunoreactivity in formalin-fixed brain tissue, the authors recently reported that tau protein is detected in neuronal cell bodies and proximal dendrites, gray matter neuropil, axons, and glial cells in normal human hippocampus and neocortex.	Formaldehyde	110-118	microtubule associated protein tau	Homo sapiens	174-177
1599705-8	1992	Naive spleen cells of both strains in vitro could produce a large amount of interferon-gamma (IFN-gamma) one day after they were stimulated with formalin-killed L. pneumophila.	Formaldehyde	145-153	interferon gamma	Mus musculus	76-92
1534668-8	1992	This conclusion is supported by the observation that DC pulsed with formalin-modified FnBP (with a 65% decreased ability to bind fibronectin) formed fewer clusters with T-immune cells than dendritic cells pulsed with native, non-treated FnBP.	Formaldehyde	68-76	fibronectin 1	Mus musculus	129-140
1599705-8	1992	Naive spleen cells of both strains in vitro could produce a large amount of interferon-gamma (IFN-gamma) one day after they were stimulated with formalin-killed L. pneumophila.	Formaldehyde	145-153	interferon gamma	Mus musculus	94-103
1347094-3	1992	Mutations were not found in Ki-ras, but 9 p53 mutations, including 2 deletions, were found in 7 patients by direct DNA sequencing after polymerase chain reaction amplification of DNA from formalin-fixed, paraffin-embedded tissue.	Formaldehyde	188-196	tumor protein p53	Homo sapiens	42-45
1385623-6	1992	Two Mabs are useful for the detection of B-50 immunoreactivity in formalin-fixed human and rat brain tissues.	Formaldehyde	66-74	growth associated protein 43	Homo sapiens	41-45
1583889-7	1992	In summary, direct sequencing of amplified DNA from either frozen tumors or formalin-fixed, paraffin-embedded tissues can be more sensitive than NIH 3T3 transfection for detection of codon 13-activated K-ras genes.	Formaldehyde	76-84	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	202-207
1348720-0	1992	Proliferating cell nuclear antigen (PCNA) expression in formalin-fixed tissue of non-small cell lung carcinoma.	Formaldehyde	56-64	proliferating cell nuclear antigen	Homo sapiens	0-34
1587149-1	1992	Bovine rhodopsin was subjected to reductive methylation in the dark using formaldehyde and high specific activity sodium borotritide.	Formaldehyde	74-86	rhodopsin	Bos taurus	7-16
1348720-0	1992	Proliferating cell nuclear antigen (PCNA) expression in formalin-fixed tissue of non-small cell lung carcinoma.	Formaldehyde	56-64	proliferating cell nuclear antigen	Homo sapiens	36-40
1552909-5	1992	A set of seven formaldehyde-induced deficiencies of unc-22 and surrounding loci were isolated to facilitate the positioning of essential genes on the genetic and physical maps.	Formaldehyde	15-27	Twitchin	Caenorhabditis elegans	52-58
1380026-2	1992	This protein can be localized immunohistochemically in formalin-fixed paraffin-embedded material using a monoclonal antibody NCL-CB11; positive membrane staining correlates with gene amplification and protein overexpression in breast cancer.	Formaldehyde	55-63	nucleolin	Homo sapiens	125-128
1323601-6	1992	In another patient the same mutation in codon 61 of the N-ras gene was found in cirrhotic liver tissue and in all four patients the same mutation was also detected in formalin-fixed, paraffin-embedded liver biopsy HCC tissue obtained at diagnosis.	Formaldehyde	167-175	NRAS proto-oncogene, GTPase	Homo sapiens	56-61
1737795-4	1992	High molecular weight RADS-vWF and RGES-vWF multimers inhibited binding of 125I-vWF to a mixture of insolubilized native type I and III collagen and competed effectively with 125I-vWF for binding to formalin-fixed platelets in the presence of ristocetin, indicating functional collagen and platelet glycoprotein Ib binding.	Formaldehyde	199-207	von Willebrand factor	Homo sapiens	27-30
1737752-1	1992	Although the platelet ADP receptor is thought to exhibit a high degree of structural selectivity, adenosine 5"-O-(thiotriphosphate) (ATP alpha S) is a potent inhibitor of ADP-induced platelet activation and has been recently shown to bind with high affinity (Kd 3 +/- 0.1 nM) to formaldehyde-fixed platelets and to be photoincorporated into an 18-kDa fragment beginning at Tyr-198 of glycoprotein (GP) IIb alpha (Greco, N. J., Yamamoto, N., Jackson, B. W., Tandon, N. N., Moos, M., Jr., and Jamieson, G. A.	Formaldehyde	279-291	purinergic receptor P2Y12	Homo sapiens	13-34
1737795-4	1992	High molecular weight RADS-vWF and RGES-vWF multimers inhibited binding of 125I-vWF to a mixture of insolubilized native type I and III collagen and competed effectively with 125I-vWF for binding to formalin-fixed platelets in the presence of ristocetin, indicating functional collagen and platelet glycoprotein Ib binding.	Formaldehyde	199-207	von Willebrand factor	Homo sapiens	40-43
1737795-4	1992	High molecular weight RADS-vWF and RGES-vWF multimers inhibited binding of 125I-vWF to a mixture of insolubilized native type I and III collagen and competed effectively with 125I-vWF for binding to formalin-fixed platelets in the presence of ristocetin, indicating functional collagen and platelet glycoprotein Ib binding.	Formaldehyde	199-207	von Willebrand factor	Homo sapiens	40-43
1737795-4	1992	High molecular weight RADS-vWF and RGES-vWF multimers inhibited binding of 125I-vWF to a mixture of insolubilized native type I and III collagen and competed effectively with 125I-vWF for binding to formalin-fixed platelets in the presence of ristocetin, indicating functional collagen and platelet glycoprotein Ib binding.	Formaldehyde	199-207	von Willebrand factor	Homo sapiens	40-43
1572388-4	1992	Formaldehyde (33 microM) for 10 min at 23 degrees C attached 58 fibrinogen molecules per erythrocyte.	Formaldehyde	0-12	fibrinogen beta chain	Homo sapiens	64-74
1370756-13	1992	Synaptophysin is the most reliable immunohistological marker for central neurocytomas; however, immunoreactivity could be lost with long formalin fixation.	Formaldehyde	137-145	synaptophysin	Homo sapiens	0-13
1371204-5	1992	A further MAb, IT-Ks20.8, recognized CK 20 in sections of formalin-fixed, paraffin-embedded tissue samples.	Formaldehyde	58-66	keratin 20	Homo sapiens	37-42
1371175-3	1992	We evaluated 24 formalin fixed paraffin embedded tissue specimens of cervical carcinoma in situ for the presence of estrogen receptor by the immunoperoxidase technique.	Formaldehyde	16-24	estrogen receptor 1	Homo sapiens	116-133
1347557-1	1992	We have investigated whether monoclonal antibody (PC10) of proliferating cell nuclear antigen (PCNA) could be useful as a marker of proliferating cells within formalin-fixed, paraffin-embedded tissue sections of 140 gynecological tumors and their related lesions.	Formaldehyde	159-167	proliferating cell nuclear antigen	Homo sapiens	59-93
1281953-4	1992	In contrast, all tau epitopes were detected in NFT in tissue fixed in formaldehyde for prolonged periods of time.	Formaldehyde	70-82	microtubule associated protein tau	Homo sapiens	17-20
1375354-2	1992	Polyclonal antibody to apoB immunosustained senile plaque amyloid, vascular amyloid, subpial amyloid deposits and intracellular NFTs in formalin-fixed, paraffin-embedded brain sections from patients with Alzheimer disease.	Formaldehyde	136-144	apolipoprotein B	Homo sapiens	23-27
1537467-3	1992	A purified system containing phospholipid, NADPH-cytochrome P450 reductase, P4502E1, and NADPH oxidized glycerol to formaldehyde.	Formaldehyde	116-128	cytochrome p450 oxidoreductase	Rattus norvegicus	43-74
1377856-4	1992	As shown in preparations of human retina and pineal organ, IRBP can be successfully demonstrated in formalin-fixed and paraffin-embedded tissue: the IRBP immunoreaction is located to the outer and inner segments of retinal photoreceptor cells and to perikarya of certain pinealocytes.	Formaldehyde	100-108	retinol binding protein 3	Homo sapiens	59-63
1339180-2	1992	We detected messenger RNA (mRNA) specific for the enzyme ODC in 18 patients with hepatocellular carcinoma by an in situ hybridization technique using a radiolabelled ODC probe on formalin-fixed liver specimens.	Formaldehyde	179-187	ornithine decarboxylase 1	Homo sapiens	57-60
1377856-4	1992	As shown in preparations of human retina and pineal organ, IRBP can be successfully demonstrated in formalin-fixed and paraffin-embedded tissue: the IRBP immunoreaction is located to the outer and inner segments of retinal photoreceptor cells and to perikarya of certain pinealocytes.	Formaldehyde	100-108	retinol binding protein 3	Homo sapiens	149-153
1377856-5	1992	Examination of formalin-fixed, paraffin-embedded biopsy specimens of 66 cerebellar medullo-blastomas revealed varying numbers of IRBP-immuno-reactive tumor cells in 19 cases that were formerly shown to contain rod-opsin and S-antigen immunoreaction.	Formaldehyde	15-23	retinol binding protein 3	Homo sapiens	129-133
1571019-4	1992	The number of UCHL-1 positive cell nuclei was almost on the border line of our PCR sensitivity in formalin-fixed tissue, which was estimated to be 20-200 copies.	Formaldehyde	98-106	ubiquitin C-terminal hydrolase L1	Homo sapiens	14-20
1391875-5	1992	Dimerisation of the EGF-R in the absence of the ligand has been established on formalin-fixed A-431 cells.	Formaldehyde	79-87	epidermal growth factor receptor	Homo sapiens	20-25
1384864-9	1992	Pretreatment with 10 micrograms/ml formaldehyde significantly enhanced beta-hexosaminidase release from PMC stimulated with antigen or A23187.	Formaldehyde	35-47	O-GlcNAcase	Mus musculus	71-90
1384864-10	1992	Compared to sham-treated PMC, PMC pretreated with formaldehyde expressed a markedly depressed natural cytotoxicity for the tumor target WEHI-164 (an assay of tumor necrosis factor alpha activity).	Formaldehyde	50-62	tumor necrosis factor	Mus musculus	158-185
1569122-5	1992	Most importantly, they also permit the detection of p53 in archival tumour material that has been conventionally fixed in formalin and embedded in paraffin wax.	Formaldehyde	122-130	tumor protein p53	Homo sapiens	52-55
1374782-9	1992	Physical (adsorption to a solid matrix) or chemical (deglycosylation or formalin-fixation) alteration of CEA is required for binding of CP4 to CEA.	Formaldehyde	72-80	CEA cell adhesion molecule 3	Homo sapiens	105-108
1374782-9	1992	Physical (adsorption to a solid matrix) or chemical (deglycosylation or formalin-fixation) alteration of CEA is required for binding of CP4 to CEA.	Formaldehyde	72-80	CEA cell adhesion molecule 3	Homo sapiens	143-146
1329310-2	1992	Recombinant tumour necrosis factor alpha (TNF) was biotinylated via amino-groups and the resultant probe was applied to formalin-fixed, paraffin-embedded tissue sections of 94 primary bronchial carcinomas and to normal peripheral lung parenchyma.	Formaldehyde	120-128	tumor necrosis factor	Homo sapiens	42-45
1729539-9	1992	The antigen recognized by mAb Due ABC 3 was stable to fixation with formaldehyde and paraffin emmbedding, different proteases, alkaline treatment and heat exposure up to 70C.	Formaldehyde	68-80	ATP-binding cassette, sub-family A (ABC1), member 3	Mus musculus	34-39
1302356-0	1992	[Activity of selected enzymes of peripheral blood erythrocytes and serum haptoglobin levels in workers occupationally exposed to styrene and formaldehyde].	Formaldehyde	141-153	haptoglobin	Homo sapiens	73-84
1302356-1	1992	In 48 and 30 workers exposed to styrene and formaldehyde respectively activities of erythrocyte acetylcholinesterase lactate dehydrogenase and glucose-6-phosphate dehydrogenase, were determined.	Formaldehyde	44-56	glucose-6-phosphate dehydrogenase	Homo sapiens	143-176
1302356-4	1992	Moreover, increased erythrocyte lactate dehydrogenase activity and decreased serum haptoglobin level was found in workers exposed to formaldehyde for 3-24 months.	Formaldehyde	133-145	haptoglobin	Homo sapiens	83-94
1350695-1	1992	The expression of the c-erbB-2 proto-oncogene product was investigated immunohistochemically in 474 formalin-fixed and paraffin-embedded human breast tissue samples.	Formaldehyde	100-108	erb-b2 receptor tyrosine kinase 2	Homo sapiens	22-30
1357815-2	1992	We have previously reported on a monoclonal antibody, TJ4C4, which is able to specifically detect p68 in formalin-fixed, paraffin-embedded tissue.	Formaldehyde	105-113	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	98-101
1359701-7	1992	In paraffin sections PCNA could be detected after methacarn fixation as well as after controled fixation at 4 degrees C in 4% paraformaldehyde for 1 h and in most biopsies routinely fixed with 10% formalin.	Formaldehyde	197-205	proliferating cell nuclear antigen	Homo sapiens	21-25
1311001-7	1992	CONCLUSIONS: Albumin mRNA can be detected in sections of formalin fixed, wax embedded liver, a digoxigenin labelled probe is ideally suited for in situ hybridisation of liver because there is no background from the detection system.	Formaldehyde	57-65	albumin	Homo sapiens	13-20
1611281-7	1992	Furthermore, when mice were intravenously injected with 20 micrograms of CK-M, IL-2 and IFN-gamma production by splenocytes, upon stimulation with either formalin-killed C. kutscheri or mitogens, was significantly higher on day 10 of treatment than on day 2.	Formaldehyde	154-162	creatine kinase, muscle	Mus musculus	73-77
1611281-7	1992	Furthermore, when mice were intravenously injected with 20 micrograms of CK-M, IL-2 and IFN-gamma production by splenocytes, upon stimulation with either formalin-killed C. kutscheri or mitogens, was significantly higher on day 10 of treatment than on day 2.	Formaldehyde	154-162	interleukin 2	Mus musculus	79-83
1611281-7	1992	Furthermore, when mice were intravenously injected with 20 micrograms of CK-M, IL-2 and IFN-gamma production by splenocytes, upon stimulation with either formalin-killed C. kutscheri or mitogens, was significantly higher on day 10 of treatment than on day 2.	Formaldehyde	154-162	interferon gamma	Mus musculus	88-97
1284893-1	1992	The fixation in ethanol or formalin for trypsin digestion in immunohistochemical detection of cytokeratins and vimentin was assessed in a case of ovarian cystadenofibrocarcinoma.	Formaldehyde	27-35	vimentin	Homo sapiens	111-119
1631902-0	1992	Methylamine metabolism to formaldehyde by vascular semicarbazide-sensitive amine oxidase.	Formaldehyde	26-38	amine oxidase, copper containing 3	Rattus norvegicus	51-88
1631902-1	1992	The capacity of the vascular enzyme, semicarbazide-sensitive amine oxidase (SSAO), to metabolize methylamine to the potentially toxic product, formaldehyde, was tested using rat aortic homogenates and purified porcine aortic SSAO.	Formaldehyde	143-155	amine oxidase, copper containing 3	Rattus norvegicus	37-74
1631902-1	1992	The capacity of the vascular enzyme, semicarbazide-sensitive amine oxidase (SSAO), to metabolize methylamine to the potentially toxic product, formaldehyde, was tested using rat aortic homogenates and purified porcine aortic SSAO.	Formaldehyde	143-155	amine oxidase, copper containing 3	Rattus norvegicus	76-80
1631902-1	1992	The capacity of the vascular enzyme, semicarbazide-sensitive amine oxidase (SSAO), to metabolize methylamine to the potentially toxic product, formaldehyde, was tested using rat aortic homogenates and purified porcine aortic SSAO.	Formaldehyde	143-155	amine oxidase, copper containing 3	Rattus norvegicus	225-229
1631902-3	1992	Inhibitor studies using the specific SSAO inhibitor semicarbazide and the monoamine oxidase inhibitor pargyline indicate that SSAO is responsible for metabolism of methylamine to formaldehyde.	Formaldehyde	179-191	amine oxidase, copper containing 3	Rattus norvegicus	37-41
1631902-3	1992	Inhibitor studies using the specific SSAO inhibitor semicarbazide and the monoamine oxidase inhibitor pargyline indicate that SSAO is responsible for metabolism of methylamine to formaldehyde.	Formaldehyde	179-191	amine oxidase, copper containing 3	Rattus norvegicus	126-130
1631902-4	1992	These results suggest the possibility that elevated methylamine found in several pathologic states (such as uremia and diabetes mellitus), or generated from exogenous sources, could result in overproduction of formaldehyde in tissues with high SSAO activity, especially blood vessels.	Formaldehyde	210-222	amine oxidase, copper containing 3	Rattus norvegicus	244-248
1413493-1	1992	The expression of the p53 gene product was investigated immunocytochemically in a retrospective series of 164 formalin-fixed paraffin-embedded invasive breast carcinomas with pathologically proven negative lymph nodes.	Formaldehyde	110-118	tumor protein p53	Homo sapiens	22-25
1466152-1	1992	The occurrence of immunoreactive cystatin C (CC) in normal and neoplastic cells of the human pancreas and gut was investigated using an indirect streptavidin-biotin method on formaldehyde-fixed and paraffin-embedded tissues.	Formaldehyde	175-187	cystatin C	Homo sapiens	33-43
1466152-1	1992	The occurrence of immunoreactive cystatin C (CC) in normal and neoplastic cells of the human pancreas and gut was investigated using an indirect streptavidin-biotin method on formaldehyde-fixed and paraffin-embedded tissues.	Formaldehyde	175-187	cystatin C	Homo sapiens	45-47
1764370-4	1991	One of the antibodies, CM1, recognises p53 in formalin-fixed, paraffin-embedded archival material and using this reagent we found immunodetectable p53 in 28 of 124 (23%) pancreatic cancers.	Formaldehyde	46-54	tumor protein p53	Homo sapiens	39-42
1636247-2	1992	Using a new monoclonal antibody (PG-M1) directed against a formalin-resistant epitope on macrophages and by employment of the Prussian blue reaction, quantitation of this cell population was feasible.	Formaldehyde	59-67	phosphoglucomutase 1	Homo sapiens	33-38
18965312-3	1991	Formaldehyde permeates the membrane and reacts with 2-(hydroxymethyl)piperidine (2-HMP) coated on the surface of XAD-2.	Formaldehyde	0-12	inner membrane mitochondrial protein	Homo sapiens	83-86
1687240-1	1991	Detection of c-erbB-2 oncogene product expression by monoclonal antibody staining (avidin-biotin technique) in formalin-fixed, paraffin-embedded atypical hyperplasias (AH, n = 20), intraductal carcinomas (IDCA, n = 27) and invasive carcinomas (INVCA, n = 48) was compared to ploidy determinations obtained by flow cytometry (INVCA) or image analysis (AH, IDCA).	Formaldehyde	111-119	erb-b2 receptor tyrosine kinase 2	Homo sapiens	13-21
1804308-2	1991	For this reason we attempted to localize IL-1 alpha and IL-1 beta directly on formalin-fixed paraffin-embedded normal human placentae at different stages of pregnancy using immunohistochemical techniques and specific antibodies.	Formaldehyde	78-86	interleukin 1 alpha	Homo sapiens	41-51
1804308-2	1991	For this reason we attempted to localize IL-1 alpha and IL-1 beta directly on formalin-fixed paraffin-embedded normal human placentae at different stages of pregnancy using immunohistochemical techniques and specific antibodies.	Formaldehyde	78-86	interleukin 1 beta	Homo sapiens	56-65
1687809-2	1991	Formic acid pretreatment on formalin fixed, paraffin-embedded thin sections enhanced immunostaining of PrP in both congophilic and non-congophilic kuru plaques which were absent in sporadic CJD patients with short clinical courses.	Formaldehyde	28-36	prion protein	Homo sapiens	103-106
1942310-12	1991	Immunohistochemical analysis with a p185HER-2/neu polyclonal antibody, on formalin fixed, paraffin embedded tissue, was specific for HER-2/neu overexpression but not as sensitive as Northern analysis.	Formaldehyde	74-82	erb-b2 receptor tyrosine kinase 2	Homo sapiens	46-49
1719801-2	1991	Monitoring of the quality of antigen preservation and the uniformity of tissue fixation in paraffin-embedded, formaldehyde-fixed tissues is facilitated by the routine use of an antibody to an epitope of vimentin that is partially susceptible to formaldehyde fixation.	Formaldehyde	110-122	vimentin	Homo sapiens	203-211
1719801-2	1991	Monitoring of the quality of antigen preservation and the uniformity of tissue fixation in paraffin-embedded, formaldehyde-fixed tissues is facilitated by the routine use of an antibody to an epitope of vimentin that is partially susceptible to formaldehyde fixation.	Formaldehyde	245-257	vimentin	Homo sapiens	203-211
1687018-3	1991	Formaldehyde production was inhibited by substrates and ligands for cytochrome P-450 such as aniline, p-nitrophenol, pyrazole, and 4-methylpyrazole, and inhibitors such as tryptamine, cimetidine, and miconazole.	Formaldehyde	0-12	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	68-84
1942310-12	1991	Immunohistochemical analysis with a p185HER-2/neu polyclonal antibody, on formalin fixed, paraffin embedded tissue, was specific for HER-2/neu overexpression but not as sensitive as Northern analysis.	Formaldehyde	74-82	erb-b2 receptor tyrosine kinase 2	Homo sapiens	40-49
32357643-7	1991	These results indicate that tyrosine hydroxylase may be another useful marker for neuroblastic tumors and that chromogranin A mRNA can be detected in routinely processed formalin-fixed paraffin-embedded tissue sections.	Formaldehyde	170-178	chromogranin A	Homo sapiens	111-125
1939610-5	1991	The crosslinking efficiency of formaldehyde between myosin heads and thin filament surface, measured by radial stiffness increase, was found to begin to markedly increase when the relaxed fibre with rest L was compressed to a d of nearly 35 nm.	Formaldehyde	31-43	myosin heavy chain 14	Homo sapiens	52-58
1654024-5	1991	When formaldehyde fixation was omitted, more than 50% of the pepsin-digested ARH-77 cells had strong nuclear staining.	Formaldehyde	5-17	low density lipoprotein receptor adaptor protein 1	Homo sapiens	77-80
1654872-6	1991	Glial fibrillary acidic protein expression in chondromyxoid and chordoid tumors was studied in formaldehyde solution-fixed, paraffin-embedded sections of 20 pleomorphic adenomas and 10 chordomas by the immunoperoxidase method with the use of commercially available monoclonal (n = 2) and polyclonal (n = 1) antibodies.	Formaldehyde	95-107	glial fibrillary acidic protein	Homo sapiens	0-31
1720817-8	1991	Our study shows that the keratin 7 Mab OV-TL 12/30 is an excellent marker for tumour histopathology since it is reactive in paraffin-embedded formalin-fixed human tissues.	Formaldehyde	142-150	keratin 7	Homo sapiens	25-34
1716444-2	1991	All the tumors contained tumor cells which showed a positive immunoreactivity for desmin in formaldehyde-fixed and paraffin-embedded sections, but none of the seven anti-desmin antibodies used alone produced a distinct positive staining in all the tumors.	Formaldehyde	92-104	desmin	Homo sapiens	82-88
1680544-1	1991	An enhanced immunohistochemical procedure to detect proliferating cell nuclear antigen (PCNA), an endogenous cell replication marker, has been successfully applied to formalin-fixed, paraffin-embedded archival rat and mouse tissues.	Formaldehyde	167-175	proliferating cell nuclear antigen	Rattus norvegicus	52-86
1680544-1	1991	An enhanced immunohistochemical procedure to detect proliferating cell nuclear antigen (PCNA), an endogenous cell replication marker, has been successfully applied to formalin-fixed, paraffin-embedded archival rat and mouse tissues.	Formaldehyde	167-175	proliferating cell nuclear antigen	Rattus norvegicus	88-92
1680544-3	1991	Successful immunohistochemical staining of PCNA can be consistently obtained in tissues fixed for over 24 months in formalin and in sections made from paraffin blocks stored in our tissue archives for up to 19 months.	Formaldehyde	116-124	proliferating cell nuclear antigen	Rattus norvegicus	43-47
1758871-1	1991	The monoclonal antibody mES 13 was previously produced against bacterially expressed BALB ras p21 and was reported to have both membrane and cytoplasmic reactivity in formalin-fixed, paraffin-embedded tissue sections.	Formaldehyde	167-175	esterase 13	Mus musculus	24-30
2069213-8	1991	The results of our study suggest that the Ber-EP4 antibody may have great use in the differential diagnosis of mesothelioma versus adenocarcinoma, particularly when only formalin-fixed tissue is available.	Formaldehyde	170-178	prostaglandin E receptor 4	Homo sapiens	46-49
1855181-2	1991	The authors compared the immunohistochemical reactivity of 13 uveal nevi and 20 uveal melanomas for HMB-45, S-100 protein, and neuron-specific enolase (NSE) in formalin-fixed, paraffin-embedded sections.	Formaldehyde	160-168	enolase 2	Homo sapiens	152-155
1724578-0	1991	Induction of CD14 antigen on the surface of U937 cells by an interleukin-6 autocrine mechanism after culture with formalin-killed gram-negative bacteria.	Formaldehyde	114-122	CD14 molecule	Homo sapiens	13-17
1724578-0	1991	Induction of CD14 antigen on the surface of U937 cells by an interleukin-6 autocrine mechanism after culture with formalin-killed gram-negative bacteria.	Formaldehyde	114-122	interleukin 6	Homo sapiens	61-74
1724578-1	1991	In order to better understand the regulation of CD14 antigen on the surface of the monocyte-like cell line U937 in response to bacteria, the expression and regulation of CD14 antigen on these cells when cultured with formalin-killed bacteria were determined using the monoclonal antibody MY-4 and analyzed by means of the indirect immunofluorescence method.	Formaldehyde	217-225	CD14 molecule	Homo sapiens	170-174
1724578-2	1991	CD14 expression was induced on the U937 cells after about 48 hours of culture with all of the formalin-killed Gram-negative bacteria used in this study but with none of the Gram-positive bacteria.	Formaldehyde	94-102	CD14 molecule	Homo sapiens	0-4
1724578-5	1991	The U937 cells were found to produce a large amount of interleukin-6 in response to formalin-killed Salmonella enteritidis 116-54.	Formaldehyde	84-92	interleukin 6	Homo sapiens	55-68
1724578-6	1991	On the other hand, culture supernatant (referred to as conditioned medium) obtained from the U937 cells after 72 h of culture with formalin-killed Salmonella enteritidis 116-54 also induced strong expression of CD14 antigen 48 to 72 h later, and this was blocked by the addition of anti-human interleukin-6 antibody.	Formaldehyde	131-139	CD14 molecule	Homo sapiens	211-215
1724578-6	1991	On the other hand, culture supernatant (referred to as conditioned medium) obtained from the U937 cells after 72 h of culture with formalin-killed Salmonella enteritidis 116-54 also induced strong expression of CD14 antigen 48 to 72 h later, and this was blocked by the addition of anti-human interleukin-6 antibody.	Formaldehyde	131-139	interleukin 6	Homo sapiens	293-306
1724578-7	1991	These findings suggest that the expression of CD14 antigen on the surface of U937 cells cultured with formalin-killed Gram-negative bacteria is induced by interleukin-6 and can be explained on the basis of the autocrine mechanism of interleukin-6.	Formaldehyde	102-110	CD14 molecule	Homo sapiens	46-50
1724578-7	1991	These findings suggest that the expression of CD14 antigen on the surface of U937 cells cultured with formalin-killed Gram-negative bacteria is induced by interleukin-6 and can be explained on the basis of the autocrine mechanism of interleukin-6.	Formaldehyde	102-110	interleukin 6	Homo sapiens	155-168
1724578-7	1991	These findings suggest that the expression of CD14 antigen on the surface of U937 cells cultured with formalin-killed Gram-negative bacteria is induced by interleukin-6 and can be explained on the basis of the autocrine mechanism of interleukin-6.	Formaldehyde	102-110	interleukin 6	Homo sapiens	233-246
1872853-2	1991	The enzyme, chi chi-ADH, exhibits a kcat of 200 min-1 and a km of 4 microM for the oxidation of formaldehyde, but only in the presence of GSH.	Formaldehyde	96-108	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	20-23
1714957-1	1991	The isosteric methyleneoxy psi (CH2O) function was employed as a novel peptide-bond surrogate and incorporated into sequences of two neuropeptides, substance P (SP) and enkephalin.	Formaldehyde	32-36	proenkephalin	Rattus norvegicus	169-179
1681040-1	1991	Expression of the epidermal growth factor (EGF) receptor was evaluated by immunohistochemical staining of formalin-fixed, paraffin-embedded tumour tissues employing two antibodies raised to short synthetic peptides from the cytoplasmic domain of the molecule.	Formaldehyde	106-114	epidermal growth factor receptor	Homo sapiens	18-56
1680784-2	1991	A new monoclonal antibody (PC10) to genetically engineered PCNA has been shown to label proliferating cells in formalin-fixed paraffin-embedded normal human tissues.	Formaldehyde	111-119	proliferating cell nuclear antigen	Homo sapiens	59-63
1741920-2	1991	A murine tumor necrosis-like factor (TNF-like) was induced in the sera of CD-1 mice which had been primed with heat/formalin-inactivated Propionibacterium avidum KP-40 and subsequently exposed to LTA extracted from Staphylococcus saprophyticus strain S 1.	Formaldehyde	116-124	tumor necrosis factor	Mus musculus	37-40
1712546-0	1991	Aberrant MT2 positivity distinguishes follicular lymphoma from reactive follicular hyperplasia in B5- and formalin-fixed paraffin sections.	Formaldehyde	106-114	metallothionein 2A	Homo sapiens	9-12
1712546-5	1991	Ninety-two percent of the B5-fixed and 77% of the formalin-fixed lymphomas were MT2 positive.	Formaldehyde	50-58	metallothionein 2A	Homo sapiens	80-83
1676930-3	1991	The authors retrospectively evaluated 62 cases of lobular neoplasia for expression of the c-erbB-2 gene product on formalin-fixed, deparaffinized sections, using two monoclonal anti-erbB-2 (p185) antibodies (c-neu Ab3 and m-erb) and one polyclonal anti-erbB-2 antibody (pAb 1) by the avidin-biotin-peroxidase method.	Formaldehyde	115-123	erb-b2 receptor tyrosine kinase 2	Homo sapiens	90-98
1679345-9	1991	It was concluded that both fresh-frozen and paraffin-embedded, formalin-fixed material is suitable for assessment of HER-2/neu protein overexpression by image analysis and provides comparable HER-2/neu expression values in most cases.	Formaldehyde	63-71	erb-b2 receptor tyrosine kinase 2	Homo sapiens	117-126
1679345-9	1991	It was concluded that both fresh-frozen and paraffin-embedded, formalin-fixed material is suitable for assessment of HER-2/neu protein overexpression by image analysis and provides comparable HER-2/neu expression values in most cases.	Formaldehyde	63-71	erb-b2 receptor tyrosine kinase 2	Homo sapiens	192-201
1903170-0	1991	Hydrated autoclave pretreatment enhances tau immunoreactivity in formalin-fixed normal and Alzheimer"s disease brain tissues.	Formaldehyde	65-73	microtubule associated protein tau	Homo sapiens	41-44
1711075-4	1991	Like most CD45 antibodies, reactivity can be demonstrated in fresh frozen as well as in formalin-fixed, paraffin-embedded tissues.	Formaldehyde	88-96	protein tyrosine phosphatase receptor type C	Homo sapiens	10-14
2049776-1	1991	Point mutation in codons 12, 13 and 61 of the K-ras oncogene in gastric epithelial tumors were investigated by polymerase chain reaction from sections of formalin-fixed, paraffin-embedded tissue followed by dot-blot hybridization with mutation-specific oligonucleotide probes.	Formaldehyde	154-162	KRAS proto-oncogene, GTPase	Homo sapiens	46-51
1918508-4	1991	As an example, we detail the detection of a point mutation at codon 61 of the human N-ras gene in DNA from a formalin-fixed paraffin-embedded malignant melanoma specimen.	Formaldehyde	109-117	NRAS proto-oncogene, GTPase	Homo sapiens	84-89
1827754-2	1991	We used single-stranded, asymmetric, radiolabelled RNA probes to detect the amount of ras and gli mRNA present in formalin-fixed, paraffin-embedded tumor material.	Formaldehyde	114-122	GLI family zinc finger 1	Homo sapiens	94-97
1722381-2	1991	Using an immunohistochemical technique and a panel of monoclonal antibodies we have localized IFN-alpha, -beta and -gamma directly on formalin-fixed paraffin-embedded normal human placentae at different stages of pregnancy and in the hydatidiform mole.	Formaldehyde	134-142	interferon alpha 1	Homo sapiens	94-121
1675840-0	1991	Growth fraction estimation of malignant lymphomas in formalin-fixed paraffin-embedded tissue using anti-PCNA/Cyclin 19A2.	Formaldehyde	53-61	proliferating cell nuclear antigen	Homo sapiens	104-108
1675840-0	1991	Growth fraction estimation of malignant lymphomas in formalin-fixed paraffin-embedded tissue using anti-PCNA/Cyclin 19A2.	Formaldehyde	53-61	proliferating cell nuclear antigen	Homo sapiens	109-115
1675840-4	1991	The authors describe a method for detection of PCNA/Cyclin in formalin-fixed, paraffin-embedded tissue using a routine biotin-streptavidin immunohistochemical system that employs an anti-IgM, mu-chain-specific second-stage antibody.	Formaldehyde	62-70	proliferating cell nuclear antigen	Homo sapiens	47-58
1903170-1	1991	We developed a new immunohistochemical method by which normal tau antigenicity can be visualized in paraffin sections of formalin-fixed brain tissue.	Formaldehyde	121-129	microtubule associated protein tau	Homo sapiens	62-65
1903170-6	1991	In addition, hydrated autoclaving had an enhancing effect on the abnormally phosphorylated (modified) tau immunoreactivity in formalin-fixed brains.	Formaldehyde	126-134	microtubule associated protein tau	Homo sapiens	102-105
1903170-9	1991	Immunoblot analysis showed that normal or modified tau immunoreactivity was totally or partially eliminated on formalin treatment and could be revisualized by hydrated autoclaving, an event presumably related to recovering of formalin-masked tau antigens through denaturation by hydrated autoclaving.	Formaldehyde	111-119	microtubule associated protein tau	Homo sapiens	51-54
1903170-9	1991	Immunoblot analysis showed that normal or modified tau immunoreactivity was totally or partially eliminated on formalin treatment and could be revisualized by hydrated autoclaving, an event presumably related to recovering of formalin-masked tau antigens through denaturation by hydrated autoclaving.	Formaldehyde	226-234	microtubule associated protein tau	Homo sapiens	51-54
1903170-9	1991	Immunoblot analysis showed that normal or modified tau immunoreactivity was totally or partially eliminated on formalin treatment and could be revisualized by hydrated autoclaving, an event presumably related to recovering of formalin-masked tau antigens through denaturation by hydrated autoclaving.	Formaldehyde	226-234	microtubule associated protein tau	Homo sapiens	242-245
2030148-3	1991	Compared with periodic acid Schiff, immunostaining with a formalin resistant monoclonal antibody against glycoprotein IIIa (Y2/51(CD61) showed a clinically important proportion of immature elements.	Formaldehyde	58-66	integrin subunit beta 3	Homo sapiens	130-134
2060766-2	1991	In cell-free extracts of all formaldehyde-resistant strains a glutathione-dependent formaldehyde dehydrogenase activity was demonstrated.	Formaldehyde	29-41	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	84-110
2006877-0	1991	The human progenitor cell antigen (CD34) is localized on endothelial cells, dermal dendritic cells, and perifollicular cells in formalin-fixed normal skin, and on proliferating endothelial cells and stromal spindle-shaped cells in Kaposi"s sarcoma.	Formaldehyde	128-136	CD34 molecule	Homo sapiens	35-39
2006877-2	1991	In either cryostat sections of snap-frozen skin, or formalin-fixed paraffin-embedded sections of normal skin, anti-CD34 monoclonal antibody immunostained vascular endothelial cells and perivascular/interstitial dendritic cells, particularly in the reticular dermis.	Formaldehyde	52-60	CD34 molecule	Homo sapiens	115-119
1850286-2	1991	Air-dried and formalin-fixed cells, stained for MPO, appeared with a cytoplasmic fluorescence and unstained nuclei.	Formaldehyde	14-22	myeloperoxidase	Homo sapiens	48-51
1705091-1	1991	The authors immunohistochemically assessed the presence of estrogen receptor (ER) in formalin-fixed, paraffin-embedded tissue sections of 68 breast carcinomas by an automated method using Pronase (CalBiochem, La Jolla, CA) predigestion and alkaline phosphatase detection (Method 1).	Formaldehyde	85-93	estrogen receptor 1	Homo sapiens	59-76
1705091-1	1991	The authors immunohistochemically assessed the presence of estrogen receptor (ER) in formalin-fixed, paraffin-embedded tissue sections of 68 breast carcinomas by an automated method using Pronase (CalBiochem, La Jolla, CA) predigestion and alkaline phosphatase detection (Method 1).	Formaldehyde	85-93	estrogen receptor 1	Homo sapiens	78-80
1705091-5	1991	These findings indicate that ER immunohistochemical studies on formalin-fixed paraffin-embedded tissues (as assayed by Method 1) provide useful clinical information when the results are positive.	Formaldehyde	63-71	estrogen receptor 1	Homo sapiens	29-31
1998339-3	1991	In this study, lymphocyte MTHFR specific activities in the thermolabile variant and control groups were 5.58 +/- 0.91 and 10.33 +/- 2.89 nmol formaldehyde formed/mg protein/h, respectively.	Formaldehyde	142-154	methylenetetrahydrofolate reductase	Homo sapiens	26-31
2025606-8	1991	We conclude that the expression EGF-R can be detected reliably by the F4 antibody in both the fresh frozen and formalin fixed, paraffin embedded material and could be useful in assessing the clinical importance of EGF-R in archival tumour material.	Formaldehyde	111-119	epidermal growth factor receptor	Homo sapiens	32-37
1991268-1	1991	With a newly developed monoclonal anti-PTHrP antibody, 4B3, the immunohistochemical localization of the parathyroid hormone-related protein (PTHrP) was studied on the formalin-fixed and paraffin-embedded sections of normal human tissues and various subtypes of lung cancer.	Formaldehyde	167-175	parathyroid hormone like hormone	Homo sapiens	104-139
1902452-1	1991	The presence of point mutation at codons 12, 13 and 61 of the c-Ki-ras oncogene was investigated in 7 cases of gastric adenoma and 35 cases of gastric adenocarcinoma using DNA samples from formalin-fixed and paraffin-embedded tissues.	Formaldehyde	189-197	KRAS proto-oncogene, GTPase	Homo sapiens	62-70
1846735-10	1991	In contrast to glycerol, formaldehyde production from dimethylnitrosamine was not sensitive to catalase or iron chelators, thus disassociating the overall pathway of glycerol oxidation from typical mixed-function oxidase activity of cytochrome P450.	Formaldehyde	25-37	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	233-248
1991268-1	1991	With a newly developed monoclonal anti-PTHrP antibody, 4B3, the immunohistochemical localization of the parathyroid hormone-related protein (PTHrP) was studied on the formalin-fixed and paraffin-embedded sections of normal human tissues and various subtypes of lung cancer.	Formaldehyde	167-175	parathyroid hormone like hormone	Homo sapiens	141-146
1995435-1	1991	Air-filled albumin microspheres, asialoorosomucoid and formaldehyde-treated serum albumin are selectively taken up by endocytosis in rat liver Kupffer cells, parenchymal cells and endothelial cells, respectively.	Formaldehyde	55-67	albumin	Rattus norvegicus	76-89
1989464-6	1991	With formalin-fixed, paraffin-embedded tissue, the majority of OCL-GC and histiocytoid mononuclear cells in both cases showed immunoreactivity using monoclonal antibodies to vimentin and KP-1, with the latter preparation directed against cells of monocytic/histiocytic lineage.	Formaldehyde	5-13	vimentin	Homo sapiens	174-182
1670998-1	1991	Using a polyclonal antibody that is monospecific for the erbB-2 oncogene product, an immunohistochemical study of the expression of erbB-2 protein was performed in formalin-fixed paraffin-embedded tissue sections from 260 primary gastric cancers.	Formaldehyde	164-172	erb-b2 receptor tyrosine kinase 2	Homo sapiens	132-138
1993707-8	1991	To determine whether the scavenger receptor system that is also mainly present on endothelial cells is involved, we performed competition studies with strongly negatively charged substrates, such as dextran sulfate and formaldehyde-treated human serum albumin (fHSA).	Formaldehyde	219-231	albumin	Homo sapiens	246-259
1707023-7	1991	We report here an analysis of the reactivity of four different anti-CEA MAbs with formalin-fixed tissue sections of human primary and metastatic colorectal and ovarian carcinomas.	Formaldehyde	82-90	CEA cell adhesion molecule 3	Homo sapiens	68-71
1995435-7	1991	Degradation of 125I-tyramine-cellobiose-asialoorosomucoid in parenchymal cells started later than that of 125I-tyramine-cellobiose-formaldehyde-treated serum albumin in endothelial cells.	Formaldehyde	131-143	albumin	Rattus norvegicus	152-165
1707960-2	1991	Two peptides were immunogenic in rabbits and antisera against one peptide reacted with the pNR-2 protein in sections of formalin-fixed, paraffin-embedded breast tumour.	Formaldehyde	120-128	trefoil factor 1	Homo sapiens	91-96
1801517-10	1991	Formaldehyde or glutaraldehyde inhibited DPP I depending on the type and concentration of aldehyde.	Formaldehyde	0-12	cathepsin C	Rattus norvegicus	41-46
1847832-9	1991	Compound 48/80, a mixture of condensation products of N-methyl-p-methoxyphenethylamine with formaldehyde, known to block phosphoinositidase C and phospholipase A2, causes a dose-dependent increase in the 32P-label of PtdInsP, in T-tubule membranes.	Formaldehyde	92-104	phospholipase C beta 1	Homo sapiens	121-141
1847832-9	1991	Compound 48/80, a mixture of condensation products of N-methyl-p-methoxyphenethylamine with formaldehyde, known to block phosphoinositidase C and phospholipase A2, causes a dose-dependent increase in the 32P-label of PtdInsP, in T-tubule membranes.	Formaldehyde	92-104	phospholipase A2 group IB	Homo sapiens	146-162
2053487-0	1991	Kinetics and mechanism of methanol and formaldehyde interconversion and formaldehyde oxidation catalyzed by liver alcohol dehydrogenase.	Formaldehyde	39-51	aldo-keto reductase family 1 member A1	Homo sapiens	114-135
1958387-2	1991	Estrogen receptor (ER) was estimated immunohistochemically in formalin-fixed and paraffin-embedded tissue from the primary breast cancer in 349 postmenopausal patients with a high risk of recurrence and compared with the results of dextran-coated charcoal assay.	Formaldehyde	62-70	estrogen receptor 1	Homo sapiens	0-17
1958387-2	1991	Estrogen receptor (ER) was estimated immunohistochemically in formalin-fixed and paraffin-embedded tissue from the primary breast cancer in 349 postmenopausal patients with a high risk of recurrence and compared with the results of dextran-coated charcoal assay.	Formaldehyde	62-70	estrogen receptor 1	Homo sapiens	19-21
2053487-0	1991	Kinetics and mechanism of methanol and formaldehyde interconversion and formaldehyde oxidation catalyzed by liver alcohol dehydrogenase.	Formaldehyde	72-84	aldo-keto reductase family 1 member A1	Homo sapiens	114-135
1650662-1	1991	Polymerase chain reaction (PCR) assays were used to amplify herpes simplex virus type 1 (HSV-1) thymidine kinase (TK) sequences in DNA extracted from formalin-fixed, paraffin embedded corneas of patients undergoing corneal transplantation.	Formaldehyde	150-158	involved in nucleotide metabolism	Human alphaherpesvirus 1	114-116
1672624-2	1991	Pancreatic islet cells showing this very weak formaldehyde-induced fluorescence react immunohistochemically with antisera directed against insulin, aromatic L-amino acid decarboxylase and dopamine beta-hydroxylase and therefore appear to be islet B cells producing insulin and noradrenaline.	Formaldehyde	46-58	insulin	Gallus gallus	139-146
1672624-2	1991	Pancreatic islet cells showing this very weak formaldehyde-induced fluorescence react immunohistochemically with antisera directed against insulin, aromatic L-amino acid decarboxylase and dopamine beta-hydroxylase and therefore appear to be islet B cells producing insulin and noradrenaline.	Formaldehyde	46-58	dopa decarboxylase	Gallus gallus	148-183
1672624-2	1991	Pancreatic islet cells showing this very weak formaldehyde-induced fluorescence react immunohistochemically with antisera directed against insulin, aromatic L-amino acid decarboxylase and dopamine beta-hydroxylase and therefore appear to be islet B cells producing insulin and noradrenaline.	Formaldehyde	46-58	dopamine beta-hydroxylase	Gallus gallus	188-213
1672624-2	1991	Pancreatic islet cells showing this very weak formaldehyde-induced fluorescence react immunohistochemically with antisera directed against insulin, aromatic L-amino acid decarboxylase and dopamine beta-hydroxylase and therefore appear to be islet B cells producing insulin and noradrenaline.	Formaldehyde	46-58	insulin	Gallus gallus	265-272
1856109-1	1991	The distribution of the mRNAs for chromogranin A and B was analyzed by in situ hybridization with 35S-labeled oligonucleotide probes in formalin-fixed paraffin-embedded carcinoid tumor tissues.	Formaldehyde	136-144	chromogranin A	Homo sapiens	34-54
1726665-5	1991	For both keratin and vimentin there were false-negative findings in the formalin-fixed tumors.	Formaldehyde	72-80	vimentin	Homo sapiens	21-29
1726665-6	1991	Of these two, vimentin was het most susceptible to formalin fixation.	Formaldehyde	51-59	vimentin	Homo sapiens	14-22
1814747-2	1991	Using an ABC immunoencymatic staining technique and a P21-specific monoclonal antibody, SCI-Oncogema I, we have detected the expression of P21 in formalin-fixed, paraffin-embedded samples from 53 bladder tumors and 7 normal bladder mucosae.	Formaldehyde	146-154	H3 histone pseudogene 16	Homo sapiens	139-142
1748567-4	1991	GLUT 1 in liver, however, could successfully be demonstrated after fixation with 1% alcoholic formaldehyde.	Formaldehyde	94-106	solute carrier family 2 member 1	Rattus norvegicus	0-6
1991923-0	1991	Serum IgE and IgG to formaldehyde-human serum albumin: lack of relation to gaseous formaldehyde exposure and symptoms.	Formaldehyde	21-33	albumin	Macaca mulatta	40-53
1991923-1	1991	Fifty-five subjects were studied to determine if the presence of IgE or IgG antibodies to formaldehyde (F)-human serum albumin (HSA) was associated with exposure to gaseous F or with respiratory or conjunctival symptoms from such exposure.	Formaldehyde	90-102	albumin	Macaca mulatta	113-126
1708502-0	1991	Image analysis for quantitation of estrogen receptor in formalin-fixed paraffin-embedded sections of breast carcinoma.	Formaldehyde	56-64	estrogen receptor 1	Homo sapiens	35-52
1901913-0	1991	Immunocytochemical localization of apolipoprotein A-I using polyclonal antibodies raised against the formaldehyde-modified antigen.	Formaldehyde	101-113	apolipoprotein A1	Homo sapiens	35-53
2056968-0	1991	Analysis of N-ras gene mutations in medulloblastomas by polymerase chain reaction and oligonucleotide probes in formalin-fixed, paraffin-embedded tissues.	Formaldehyde	112-120	NRAS proto-oncogene, GTPase	Homo sapiens	12-17
2038128-1	1991	In order to study the localization of Lentil lectin (LCH)-binding glycoresidues in glomeruli from patients with a variety of glomerulopathies, and to elucidate the relationship between LCH-binding sugars and the components of the extracellular matrix, laminin and type IV collagen, investigations of formalin-fixed, paraffin-embedded kidney tissues digested with trypsin were carried out by the direct and indirect immunofluorescence microscopy techniques.	Formaldehyde	300-308	LCH	Homo sapiens	53-56
1793484-5	1991	Amplification of Ki-ras sequences from formalin-fixed, paraffin-embedded tissue by the polymerase chain reaction was followed by direct DNA sequencing.	Formaldehyde	39-47	KRAS proto-oncogene, GTPase	Rattus norvegicus	17-23
1659673-1	1991	In an earlier report, we demonstrated that subcutaneous injection of formalin in the rat hindpaw evokes a characteristic pattern of expression of the fos protein product of the c-fos protooncogene in spinal cord neurons, and that systemic morphine reversed the fos-like immunoreactivity in a dose-dependent, naloxone-reversible manner.	Formaldehyde	69-77	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	150-153
1659673-1	1991	In an earlier report, we demonstrated that subcutaneous injection of formalin in the rat hindpaw evokes a characteristic pattern of expression of the fos protein product of the c-fos protooncogene in spinal cord neurons, and that systemic morphine reversed the fos-like immunoreactivity in a dose-dependent, naloxone-reversible manner.	Formaldehyde	69-77	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	177-182
1659673-1	1991	In an earlier report, we demonstrated that subcutaneous injection of formalin in the rat hindpaw evokes a characteristic pattern of expression of the fos protein product of the c-fos protooncogene in spinal cord neurons, and that systemic morphine reversed the fos-like immunoreactivity in a dose-dependent, naloxone-reversible manner.	Formaldehyde	69-77	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	179-182
1659673-3	1991	Formalin injection produced a biphasic pain behavioral response which lasted about 1 h. There was a significant correlation between the formalin pain score and overall fos-like immunoreactivity in the lumbar enlargement.	Formaldehyde	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	168-171
1659673-3	1991	Formalin injection produced a biphasic pain behavioral response which lasted about 1 h. There was a significant correlation between the formalin pain score and overall fos-like immunoreactivity in the lumbar enlargement.	Formaldehyde	136-144	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	168-171
1659673-4	1991	The greatest numbers of labeled cells and most intense fos-like immunoreactivity were found in laminae I, IIo and V of the L4-5 segments, ipsilateral to the formalin-injected paw.	Formaldehyde	157-165	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	55-58
1815345-9	1991	It outflowed from the determination of selected serum proteins (Ig and acute phase proteins) and salivary lysozyme that the group under the combined influence of formaldehyde and toluene showed significantly lower IgG and higher alpha-1-antitrypsin (A1AT).	Formaldehyde	162-174	serpin family A member 1	Homo sapiens	229-248
1659673-6	1991	[D-Ala2, NMe-Phe4, Gly-ol5]enkephalin produced a dose-related, naloxone-reversible inhibition of both the formalin-evoked pain behavior and fos expression in the cord.	Formaldehyde	106-114	proenkephalin	Rattus norvegicus	27-37
1815345-9	1991	It outflowed from the determination of selected serum proteins (Ig and acute phase proteins) and salivary lysozyme that the group under the combined influence of formaldehyde and toluene showed significantly lower IgG and higher alpha-1-antitrypsin (A1AT).	Formaldehyde	162-174	serpin family A member 1	Homo sapiens	250-254
1711732-1	1991	The expression of keratins 8 and 14 was investigated immunohistochemically by the avidin-biotin-peroxidase (ABC) method using formalin-fixed paraffin-embedded specimens from 42 tumours of human skin appendages.	Formaldehyde	126-134	keratin 8	Homo sapiens	18-35
1979976-2	1990	The analysis was achieved by successful immunohistochemical demonstration of proliferating cell nuclear antigen in formalin-fixed paraffin-embedded tissue sections.	Formaldehyde	115-123	proliferating cell nuclear antigen	Homo sapiens	77-111
2254647-3	1990	The immunolocalization of TGF-beta 2 was investigated in formalin-fixed, paraffin-embedded cultured cells and murine tissue.	Formaldehyde	57-65	transforming growth factor, beta 2	Mus musculus	26-36
1705926-4	1990	Accordingly, purified chromogranin A (15 micrograms or less) treated in formalin and applied to nitrocellulose did not show any argentaffin reaction but displayed a dose-related argyrophil reaction.	Formaldehyde	72-80	chromogranin A	Homo sapiens	22-36
1667050-2	1991	We conclude, that the lysozyme content of sarcoidotic granulomas, estimated immunohistochemically, may be a useful morphological parameter of the activity of the disease, applicable on formol fixed and paraffin embedded bioptical material.	Formaldehyde	185-191	lysozyme	Homo sapiens	22-30
1707730-2	1990	Formalin used as a nociceptive stimulus has been shown to increase, in a biphasic manner, the amount of immunoreactive SP in the dorsal horn.	Formaldehyde	0-8	tachykinin precursor 1	Homo sapiens	119-121
1707730-5	1990	Therefore, the extent to which SP in the dorsal horn is involved with nociception as a result of formalin remains uncertain.	Formaldehyde	97-105	tachykinin precursor 1	Homo sapiens	31-33
2256119-18	1990	While not able to account for the localized toxicity of HCHO, the presence of FDH and glutathione in the epithelial layer of the nasal cavity presents a barrier to inhaled formaldehyde at low concentrations and may partially explain the observed nonlinearity of HCHO toxicity.	Formaldehyde	172-184	alcohol dehydrogenase 5 (class III), chi polypeptide	Rattus norvegicus	78-81
1703984-1	1990	Participation of the sensory neurons, especially substance P (SP)-containing neurons, in the inflammatory response induced by formalin (FOR), croton oil (CRO), mustard oil (MUS), carrageenin (CAR), dextran (DEX) and egg white (EGG) was studied in mice and rats.	Formaldehyde	126-134	tachykinin 1	Mus musculus	49-60
1703984-1	1990	Participation of the sensory neurons, especially substance P (SP)-containing neurons, in the inflammatory response induced by formalin (FOR), croton oil (CRO), mustard oil (MUS), carrageenin (CAR), dextran (DEX) and egg white (EGG) was studied in mice and rats.	Formaldehyde	126-134	tachykinin 1	Mus musculus	62-64
2256119-3	1990	This allowed us to examine the relationship between distribution of FDH and formaldehyde-induced toxicity.	Formaldehyde	76-88	alcohol dehydrogenase 5 (class III), chi polypeptide	Rattus norvegicus	68-71
2121042-4	1990	The V kappa or V lambda subgroup of the cIg or sIg also could be identified after deparaffinization and enzyme treatment of formalin-fixed, paraffin-embedded specimens.	Formaldehyde	124-132	fibronectin 1	Homo sapiens	40-43
2280823-1	1990	The effects of intracerebroventricularly administered salmon calcitonin (sCT) and calcitonin gene-related peptide (CGRP) on the behavioural response of the mouse to formalin injections were investigated.	Formaldehyde	165-173	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	82-113
2277146-4	1990	Although a few melanosomes in the tumor cells seen in electron microscopic examination provided crucial proof for the diagnosis of Spitz nevus, the positive reactivity to S-100 protein in ordinary formalin-fixed, paraffin-embedded tissues proved to be very useful in the differentiation of Spitz nevus from tumors of histiocytic origin, especially those of the mononuclear phagocytic system.	Formaldehyde	197-205	S100 calcium binding protein A1	Homo sapiens	171-176
1698030-5	1990	These results suggest that a novel protein in the calf serum, CSX, binds formalin-fixed beta amyloid, followed by H6-33 binding.	Formaldehyde	73-81	NK2 homeobox 5	Homo sapiens	62-65
2201895-9	1990	Formaldehyde fixation of the 1B2 cells eliminated basal release of TGF alpha but allowed normal processing by both PMN leukocytic and pancreatic elastase to occur.	Formaldehyde	0-12	transforming growth factor alpha	Mus musculus	67-76
1702621-0	1990	Analysis of formaldehyde-induced Adh mutations in Drosophila by RNA structure mapping and direct sequencing of PCR-amplified genomic DNA.	Formaldehyde	12-24	Alcohol dehydrogenase	Drosophila melanogaster	33-36
1702621-1	1990	Two formaldehyde-induced mutations at the Drosophila Adh locus (Adhfn45 and Adhfn46) were analyzed by determining RNA structures at different developmental stages, polymerase chain reaction (PCR) amplification of the affected genomic regions, and direct sequencing of the resulting double-stranded DNA fragments.	Formaldehyde	4-16	Alcohol dehydrogenase	Drosophila melanogaster	53-56
1695094-0	1990	Polyclonal antibodies against formaldehyde-modified apolipoprotein A-I.	Formaldehyde	30-42	apolipoprotein A1	Homo sapiens	52-70
2400243-2	1990	The following were determined for all groups: total white cell, lymphocyte, and T cell counts; T helper/suppressor ratios; total Ta1+, IL2+, and B cell counts; antibodies to formaldehyde-human serum albumin (HCHO-HSA) conjugate and autoantibodies.	Formaldehyde	174-186	albumin	Homo sapiens	193-206
1701159-5	1990	In formalin-fixed tissues the CEA-specific epitopes were absent from normal adult tissues, but this was an artefact of the fixation procedure and fresh, non-fixed colonic tissues were clearly reactive.	Formaldehyde	3-11	CEA cell adhesion molecule 3	Homo sapiens	30-33
2385242-5	1990	Characterization of the product of the interaction of methanol and 2,4-DAT indicated that methanol is activated to a reactive intermediate, probably formaldehyde, by the 9000 X g supernatant used in the Ames/Salmonella assay.	Formaldehyde	149-161	solute carrier family 6 member 3	Rattus norvegicus	71-74
2385242-6	1990	The formaldehyde subsequently reacts with 2,4-DAT to form the mutagenic product, identified as bis-5,5"(2,4,2",4"-tetraaminotolyl)methane.	Formaldehyde	4-16	solute carrier family 6 member 3	Rattus norvegicus	46-49
2192300-2	1990	For this purpose, we developed a sensitive immunoperoxidase technique to visualize MEnk-positive patches in routinely prepared formalin-fixed paraffin-embedded striatal tissues.	Formaldehyde	127-135	proopiomelanocortin	Homo sapiens	83-87
2115647-1	1990	The expression of fos protein was examined in 30 cases of human osteosarcoma as formalin-fixed and paraffin-embedded tissue sections using two monoclonal antibodies and, for five cases, as frozen sections using 3 polyclonal antibodies.	Formaldehyde	80-88	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	18-21
1977159-2	1990	We have performed immunohistochemical staining using a polyclonal antibody to the Neu oncoprotein on formalin-fixed material from normal breast, benign breast lesions, and 102 stage I node-negative breast cancers.	Formaldehyde	101-109	erb-b2 receptor tyrosine kinase 2	Homo sapiens	82-85
1977159-8	1990	This study shows that the Neu oncoprotein can be demonstrated on formalin-fixed material from normal, benign, and malignant breast lesions.	Formaldehyde	65-73	erb-b2 receptor tyrosine kinase 2	Homo sapiens	26-29
2371832-3	1990	With regard to the effects of fixatives on the staining patterns, samples fixed with formalin or 4% paraformaldehyde demonstrated CEA immunoreactivity in both the cell membrane and cytoplasm.	Formaldehyde	85-93	CEA cell adhesion molecule 3	Homo sapiens	130-133
1692857-8	1990	Maximum anti-IgE challenge of nearly homogeneous formalin-sensitive mast cells (94.3 +/- 2.1% purity, n = 6) caused the generation of both leukotriene C4 (64.6 +/- 26.4 pg/mast cell) and PGD2 (114.8 +/- 37.5 pg/mast cell).	Formaldehyde	49-57	prostaglandin D2 synthase	Homo sapiens	187-191
2085506-1	1990	We have used a monoclonal antibody against human pancreatic lipase to study the immunohistochemical expression of lipase in formalin-fixed, paraffin-embedded biopsy specimens from normal and a variety of tumoral and inflammatory skin diseases.	Formaldehyde	124-132	pancreatic lipase	Homo sapiens	49-66
2362939-2	1990	Formalin-fixed, paraffin-embedded tissue sections were deparaffinized and incubated with the labeled EGF (10 micrograms/ml) for 60 min at room temperature.	Formaldehyde	0-8	epidermal growth factor	Homo sapiens	101-104
2372497-2	1990	The expression of epidermal growth factor receptor (EGF-R) in 34 formalin fixed paraffin embedded specimens of malignant mesothelioma was examined using the F4 antibody.	Formaldehyde	65-73	epidermal growth factor receptor	Homo sapiens	18-50
2372497-2	1990	The expression of epidermal growth factor receptor (EGF-R) in 34 formalin fixed paraffin embedded specimens of malignant mesothelioma was examined using the F4 antibody.	Formaldehyde	65-73	epidermal growth factor receptor	Homo sapiens	52-57
2162795-7	1990	However, in cirrhotics, the responses to ANP infusion of UV, FENa and CH2O were far less dramatic.	Formaldehyde	70-74	natriuretic peptide A	Homo sapiens	41-44
2363851-8	1990	Material from brains perfusion-fixed with formaldehyde remained positive for astrocytic GFAP, but was negative for vimentin.	Formaldehyde	42-54	glial fibrillary acidic protein	Rattus norvegicus	88-92
1973458-0	1990	NCL-CB11, a new monoclonal antibody recognizing the internal domain of the c-erbB-2 oncogene protein effective for use on formalin-fixed, paraffin-embedded tissue.	Formaldehyde	122-130	nucleolin	Homo sapiens	0-3
1973458-0	1990	NCL-CB11, a new monoclonal antibody recognizing the internal domain of the c-erbB-2 oncogene protein effective for use on formalin-fixed, paraffin-embedded tissue.	Formaldehyde	122-130	erb-b2 receptor tyrosine kinase 2	Homo sapiens	75-83
2316510-5	1990	A monoclonal antibody against GPIb (AP-1) inhibits either ristocetin- or botrocetin-dependent vWF binding to formalin-fixed platelets from normal individuals.	Formaldehyde	109-117	von Willebrand factor	Homo sapiens	94-97
2316510-6	1990	Therefore, botrocetin-induced vWF binding to formalin-fixed platelets may reflect the interaction between vWF and platelet GPIb.	Formaldehyde	45-53	von Willebrand factor	Homo sapiens	30-33
2316510-6	1990	Therefore, botrocetin-induced vWF binding to formalin-fixed platelets may reflect the interaction between vWF and platelet GPIb.	Formaldehyde	45-53	von Willebrand factor	Homo sapiens	106-109
1690801-6	1990	This result indicates that SP is involved in the transmission of the first phase, and SST is involved in the transmission of the second phase of the Formalin-induced nociceptive response.	Formaldehyde	149-157	somatostatin	Mus musculus	86-89
2184880-1	1990	We report the use of tumour antigen (TA-4) polyclonal antiserum to assess the level and pattern of TA-4 antigen expression in formalin-fixed paraffin-embedded tissue sections from 110 patients with a range of normal, dysplastic and malignant squamous epithelia from various sites in the upper aerodigestive tract.	Formaldehyde	126-134	trace amine associated receptor 6	Homo sapiens	99-103
1689936-5	1990	The following observations were made: (1) When pronase digestion was performed before staining, desmin was equally demonstrable in tissues fixed in formalin, Zenker"s, Bouin"s, or B5 fixative; however, desmin staining was lost or significantly diminished in tissues fixed in absolute ethyl alcohol.	Formaldehyde	148-156	desmin	Homo sapiens	96-102
1690801-0	1990	Roles of substance P and somatostatin on transmission of nociceptive information induced by formalin in spinal cord.	Formaldehyde	92-100	tachykinin 1	Mus musculus	9-20
1690801-0	1990	Roles of substance P and somatostatin on transmission of nociceptive information induced by formalin in spinal cord.	Formaldehyde	92-100	somatostatin	Mus musculus	25-37
2361653-5	1990	We contend that the demonstration of TPA, possible in alcohol- or formalin-fixed tissues, may prove to be of value in the differential diagnosis of thyroid adenomas from carcinomas of follicular cell origin.	Formaldehyde	66-74	plasminogen activator, tissue type	Homo sapiens	37-40
2178530-2	1990	To test whether neutrophils infiltrate and degranulate in areas of chronic respiratory allergic inflammation, we developed an indirect immunofluorescence technique to localize neutrophil elastase in formalin-fixed, paraffin-embedded tissues.	Formaldehyde	199-207	elastase, neutrophil expressed	Homo sapiens	176-195
1691211-1	1990	BDH xylene substitute, a terpene-based product, and its mixture with anhydrous alcohol were found to be excellent replacements for xylene and carbol-xylene, respectively, in the trichrome staining technique applied to sodium acetate-acetic acid-Formalin-fixed fecal smears for detection of intestinal protozoa.	Formaldehyde	245-253	3-hydroxybutyrate dehydrogenase 1	Homo sapiens	0-3
2110593-1	1990	The aspartic proteinase zymogen, progastricsin, which occurs in normal gastroduodenal mucosa and prostate, has been localized by the immunogold-silver method in formalin-fixed, paraffin-embedded sections of metastatic adenocarcinoma in lymph nodes and liver, the primary site being known in each case.	Formaldehyde	161-169	progastricsin	Homo sapiens	33-46
2194368-0	1990	[Characteristics of elastin from the wall of human large arteries during treatment with formaldehyde].	Formaldehyde	88-100	elastin	Homo sapiens	20-27
2194368-1	1990	Biochemical studies of elastin from human large arteries wall were carried out using both native and treated with formaldehyde protein.	Formaldehyde	114-126	elastin	Homo sapiens	23-30
2194368-2	1990	No differences were observed in sensitivity of native and formaldehyde treated elastin to the effect of various proteases and to alkaline-alcohol hydrolysis.	Formaldehyde	58-70	elastin	Homo sapiens	79-86
2404608-2	1990	Pancreatic islet cells emitting intense formaldehyde-induced fluorescence also react immunohistochemically with antisera directed against glucagon, serotonin and aromatic L-amino acid decarboxylase.	Formaldehyde	40-52	dopa decarboxylase	Gallus gallus	162-197
2154140-1	1990	We evaluated a commercially available polyclonal antibody to 17 beta-estradiol as the basis for an estrogen receptor (ER) assay of breast carcinoma in formalin-fixed paraffin tissues and then compared it with both the ER-ICA antibody in serial paraffin sections and the biochemical assay of corresponding fresh tissue.	Formaldehyde	151-159	estrogen receptor 1	Homo sapiens	99-116
2154140-1	1990	We evaluated a commercially available polyclonal antibody to 17 beta-estradiol as the basis for an estrogen receptor (ER) assay of breast carcinoma in formalin-fixed paraffin tissues and then compared it with both the ER-ICA antibody in serial paraffin sections and the biochemical assay of corresponding fresh tissue.	Formaldehyde	151-159	estrogen receptor 1	Homo sapiens	118-120
2154140-8	1990	This study is the first to show that with nuclear staining only, and not cytoplasmic staining, as the parameter of positivity, the immunocytochemical assay of ER with anti-17 beta-estradiol antibody in routinely processed, formalin-fixed, archival material is an accurate and specific method for the determination of the ER status of breast carcinoma.	Formaldehyde	223-231	estrogen receptor 1	Homo sapiens	159-161
2350195-0	1990	Immunohistochemical detection of progesterone receptor in formalin-fixed and paraffin-embedded breast cancer tissue using a monoclonal antibody.	Formaldehyde	58-66	progesterone receptor	Homo sapiens	33-54
2350195-7	1990	There was an acceptable ranked correlation (r = 0.74) between IRS in formalin-fixed and paraffin-embedded parts and snap frozen parts of the same carcinoma.	Formaldehyde	69-77	isoleucyl-tRNA synthetase 1	Homo sapiens	62-65
2156188-2	1990	C-fos protein was detected immunocytochemically using two different antibodies in formalin-fixed brain sections.	Formaldehyde	82-90	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-5
2405185-2	1990	Immunohistochemical analyses on frozen and deparaffinized, formalin-fixed tissue sections have demonstrated that the Lewis X antigen is not detected in normal adult urothelium except for occasional umbrella cells.	Formaldehyde	59-67	fucosyltransferase 4	Homo sapiens	117-124
2215924-3	1990	Subcutaneous injection of dilute formalin produced a similar pattern of immunostaining at 2 h, with a greater proportion of Fos-positive neurons in laminae III-VIII than with heat.	Formaldehyde	33-41	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	124-127
1698166-4	1990	The monoclonal antibodies to c-erbB-2 and EGF-R immunostained subpopulations of tumour cells on sections of formalin-fixed, paraffin wax embedded human infiltrating and invasive ductal carcinomas of breast.	Formaldehyde	108-116	erb-b2 receptor tyrosine kinase 2	Homo sapiens	29-37
1698166-4	1990	The monoclonal antibodies to c-erbB-2 and EGF-R immunostained subpopulations of tumour cells on sections of formalin-fixed, paraffin wax embedded human infiltrating and invasive ductal carcinomas of breast.	Formaldehyde	108-116	epidermal growth factor receptor	Homo sapiens	42-47
2079108-0	1990	Enhanced immunocytochemical staining sensitivity in formalin-fixed and paraffin-embedded material by simultaneous use of PAP and ABC.	Formaldehyde	52-60	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	129-132
2079108-1	1990	The simultaneous use of two immunoperoxidase (IP) methods; e.g. the PAP (Peroxidase-antiperoxidase) and ABC (Avidin-Biotin) to localize a single antigen enhances the sensitivity of polyclonal antibodies (FVIII/RAg and laminin) or monoclonal antibodies (MABs) (against human B-, T-cells and macrophages) in routinely formalin fixed and in paraffin embedded material.	Formaldehyde	316-324	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	73-107
2088481-6	1990	Conditions are described for use of HCA2 and HC10 in immunohistochemical staining of formalin-fixed, paraffin-embedded sections.	Formaldehyde	85-93	MAGE family member C3	Homo sapiens	36-40
2088481-6	1990	Conditions are described for use of HCA2 and HC10 in immunohistochemical staining of formalin-fixed, paraffin-embedded sections.	Formaldehyde	85-93	CYCS pseudogene 25	Homo sapiens	45-49
1688935-3	1990	In this study, we examined the effect of systemic morphine on Fos-like immunoreactivity (FLI) evoked in the formalin test, a widely used model of persistent pain.	Formaldehyde	108-116	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	62-65
2215924-4	1990	With a survival time of 8 h following formalin injection, Fos immunoreactivity was virtually absent from the spinal cord.	Formaldehyde	38-46	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	58-61
3146840-1	1988	A toxoid of erythrogenic toxin type A (ET A) was prepared by formaldehyde treatment.	Formaldehyde	61-73	endothelin receptor type A	Homo sapiens	12-37
1701303-1	1990	The immunoreactivity of anti-neuron-specific enolase (NSE) and anti-Leu-7 on formalin-fixed sections of human salivary gland neoplasms was determined by the avidin-biotin-peroxidase complex method.	Formaldehyde	77-85	enolase 2	Homo sapiens	24-52
1701303-1	1990	The immunoreactivity of anti-neuron-specific enolase (NSE) and anti-Leu-7 on formalin-fixed sections of human salivary gland neoplasms was determined by the avidin-biotin-peroxidase complex method.	Formaldehyde	77-85	beta-1,3-glucuronyltransferase 1	Homo sapiens	68-73
2312605-1	1990	The reactivity of D-14 monoclonal antibody (mAb) to a specific epitope of carcinoembryonic antigen (CEA) was evaluated on formalin-fixed, paraffin-embedded tissues.	Formaldehyde	122-130	CEA cell adhesion molecule 3	Homo sapiens	74-104
3146840-1	1988	A toxoid of erythrogenic toxin type A (ET A) was prepared by formaldehyde treatment.	Formaldehyde	61-73	endothelin receptor type A	Homo sapiens	39-43
3146840-2	1988	Already 15 min after exposure to formaldehyde in isoelectric focusing the ET A band at pH 5.2 shifted to a band at pH 4.5.	Formaldehyde	33-45	endothelin receptor type A	Homo sapiens	74-78
3146840-4	1988	Formaldehyde treatment of ET A resulted in an apparent increase of electrophoretic mobility.	Formaldehyde	0-12	endothelin receptor type A	Homo sapiens	26-30
33775850-0	2021	Profilin 3 genetic architecture in glioma formalin fixed paraffin embedded (FFPE) archive.	Formaldehyde	42-50	profilin 3	Homo sapiens	0-10
3929447-9	1985	Milk stabilized with formaldehyde can also be used for the determination if stored at 4 degrees C.	Formaldehyde	21-33	Weaning weight-maternal milk	Bos taurus	0-4
33775850-4	2021	The current study explored transcriptional expression profile and genetic architecture of pfn3 in a cohort of fifty formalin fixed paraffin embedded (FFPE) human glioma archive tissues.	Formaldehyde	116-124	profilin 3	Homo sapiens	90-94
33940787-3	2022	This study aimed to analyze the capturing of TERT mutations by targeted next-generation sequencing (NGS) using formalin-fixed paraffin-embedded tissues.	Formaldehyde	111-119	telomerase reverse transcriptase	Homo sapiens	45-49
33973354-2	2021	Endogenous formaldehyde is mainly produced through the oxidative deamination of methylamine catalysed by semicarbazide-sensitive amine oxidase (SSAO) and is ubiquitous in human body fluids, tissues and cells.	Formaldehyde	11-23	amine oxidase copper containing 2	Homo sapiens	105-142
33973354-2	2021	Endogenous formaldehyde is mainly produced through the oxidative deamination of methylamine catalysed by semicarbazide-sensitive amine oxidase (SSAO) and is ubiquitous in human body fluids, tissues and cells.	Formaldehyde	11-23	amine oxidase copper containing 2	Homo sapiens	144-148
33811629-5	2021	METHODS: In the present study, the expression of TYRP1 and HIF-1alpha was investigated on 61 formalin-fixed paraffin-embedded choroidal melanoma samples by immunohistochemistry.	Formaldehyde	93-101	tyrosinase related protein 1	Homo sapiens	49-54
33811629-5	2021	METHODS: In the present study, the expression of TYRP1 and HIF-1alpha was investigated on 61 formalin-fixed paraffin-embedded choroidal melanoma samples by immunohistochemistry.	Formaldehyde	93-101	hypoxia inducible factor 1 subunit alpha	Homo sapiens	59-69
28852882-13	2018	Formalin-fixed paraffin-embedded (FFPE) tissue slides allowed evaluation of the intratumor heterogeneity of these FGFR2 biomarkers.	Formaldehyde	0-8	fibroblast growth factor receptor 2	Homo sapiens	114-119
33806698-0	2021	NFAT5 Deficiency Alleviates Formalin-Induced Inflammatory Pain Through mTOR.	Formaldehyde	28-36	nuclear factor of activated T cells 5	Mus musculus	0-5
33806698-0	2021	NFAT5 Deficiency Alleviates Formalin-Induced Inflammatory Pain Through mTOR.	Formaldehyde	28-36	mechanistic target of rapamycin kinase	Mus musculus	71-75
33806698-9	2021	Altogether, our findings suggest that NFAT5 deficiency may mitigate formalin-induced inflammatory pain by upregulating mammalian target of rapamycin (mTOR) expression and downregulating its downstream factors in spinal dorsal neurons.	Formaldehyde	68-76	nuclear factor of activated T cells 5	Homo sapiens	38-43
33806698-9	2021	Altogether, our findings suggest that NFAT5 deficiency may mitigate formalin-induced inflammatory pain by upregulating mammalian target of rapamycin (mTOR) expression and downregulating its downstream factors in spinal dorsal neurons.	Formaldehyde	68-76	mechanistic target of rapamycin kinase	Homo sapiens	119-148
33806698-9	2021	Altogether, our findings suggest that NFAT5 deficiency may mitigate formalin-induced inflammatory pain by upregulating mammalian target of rapamycin (mTOR) expression and downregulating its downstream factors in spinal dorsal neurons.	Formaldehyde	68-76	mechanistic target of rapamycin kinase	Homo sapiens	150-154
33768318-3	2021	In this study, we aim to validate the diagnostic performance of multiplex BCL2/BCL6 FISH approach in formalin-fixed paraffin-embedded FLs and DBCLs and cytological samples of DLBCL comparing to the classic set of single break-apart probes.	Formaldehyde	101-109	BCL2 apoptosis regulator	Homo sapiens	74-78
33768318-3	2021	In this study, we aim to validate the diagnostic performance of multiplex BCL2/BCL6 FISH approach in formalin-fixed paraffin-embedded FLs and DBCLs and cytological samples of DLBCL comparing to the classic set of single break-apart probes.	Formaldehyde	101-109	BCL6 transcription repressor	Homo sapiens	79-83
33816221-4	2021	Case Study: We report about SCCT that occurred 45 months after the initial diagnosis of ADC in an East Asian never-smoker woman with advanced-stage EGFR Del-19-mutant lung ADC treated with combined chemoradiotherapy before the era of insurance coverage for EGFR-TKIs in this country and subsequently gefitinib; deletion at codon 746-750 in exon 19 of the EGFR gene was ascertained in the original formalin-fixed paraffin-embedded lung biopsy tissue.	Formaldehyde	397-405	epidermal growth factor receptor	Homo sapiens	148-152
33778077-5	2021	Herein, we analyzed MMP2 mRNA expression level in cholesteatoma using RNA-in situ hybridization in formalin-fixed, paraffin-embedded (FFPE) tissue samples.	Formaldehyde	99-107	matrix metallopeptidase 2	Homo sapiens	20-24
34979375-0	2022	Formaldehyde-hardened albumin as a non-penetrating embedding matrix for frozen and vibratome sectioning.	Formaldehyde	0-12	albumin	Homo sapiens	22-29
29274566-1	2018	Formaldehyde dehydrogenase (FaldDH) is used as a catalyst to reduce formate to formaldehyde in a cascade reaction to convert CO2 to methanol.	Formaldehyde	79-91	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	0-26
29274566-1	2018	Formaldehyde dehydrogenase (FaldDH) is used as a catalyst to reduce formate to formaldehyde in a cascade reaction to convert CO2 to methanol.	Formaldehyde	79-91	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	28-34
25193240-0	2014	Abeta seeds resist inactivation by formaldehyde.	Formaldehyde	35-47	amyloid beta (A4) precursor protein	Mus musculus	0-5
25193240-5	2014	The resistance of Abeta seeds to inactivation and structural modification by formaldehyde underscores their remarkable durability, which in turn may contribute to their persistence and spread within the body.	Formaldehyde	77-89	amyloid beta (A4) precursor protein	Mus musculus	18-23
25193240-6	2014	The present findings can be exploited to establish the relationship between the molecular structure of Abeta aggregates and the variable clinical features and disease progression of AD even in archived, formalin-fixed autopsy material.	Formaldehyde	203-211	amyloid beta (A4) precursor protein	Mus musculus	103-108
1739138-3	1992	The authors used an indirect immunofluorescent technique to localize eosinophil granule major basic protein (MBP) in formalin-fixed, paraffin-embedded tissue specimens from 50 patients.	Formaldehyde	117-125	proteoglycan 2, pro eosinophil major basic protein	Homo sapiens	69-107
1739138-3	1992	The authors used an indirect immunofluorescent technique to localize eosinophil granule major basic protein (MBP) in formalin-fixed, paraffin-embedded tissue specimens from 50 patients.	Formaldehyde	117-125	myelin basic protein	Homo sapiens	109-112
34657305-7	2022	In addition, L-SOP decreased the formalin-induced upregulation of TNF-alpha as well as IL-1beta expression in the spinal cord, suggesting that activation of peripheral group III mGluRs reduces formalin-induced nociception through inhibition of the pro-inflammatory cytokines in the spinal cord.	Formaldehyde	33-41	tumor necrosis factor	Homo sapiens	66-75
34657305-7	2022	In addition, L-SOP decreased the formalin-induced upregulation of TNF-alpha as well as IL-1beta expression in the spinal cord, suggesting that activation of peripheral group III mGluRs reduces formalin-induced nociception through inhibition of the pro-inflammatory cytokines in the spinal cord.	Formaldehyde	33-41	interleukin 1 alpha	Homo sapiens	87-95
34657305-7	2022	In addition, L-SOP decreased the formalin-induced upregulation of TNF-alpha as well as IL-1beta expression in the spinal cord, suggesting that activation of peripheral group III mGluRs reduces formalin-induced nociception through inhibition of the pro-inflammatory cytokines in the spinal cord.	Formaldehyde	193-201	interleukin 1 alpha	Homo sapiens	87-95
34715746-6	2022	This study was undertaken to determine the optimal fixation method, methanol or formalin, for the detection of claudin 1 and E-cadherin by immunofluorescence in five different human breast cancer cell lines.	Formaldehyde	80-88	claudin 1	Homo sapiens	111-120
34715746-6	2022	This study was undertaken to determine the optimal fixation method, methanol or formalin, for the detection of claudin 1 and E-cadherin by immunofluorescence in five different human breast cancer cell lines.	Formaldehyde	80-88	cadherin 1	Homo sapiens	125-135
34826712-9	2022	Moreover, local injection of NOP01 markedly suppressed the expression of c-Fos protein induced by formalin in ipsilateral trigeminal ganglion (TG) neurons.	Formaldehyde	98-106	FBJ osteosarcoma oncogene	Mus musculus	73-78
34919280-0	2022	ADH2/GSNOR1 is a key player in limiting genotoxic damage mediated by formaldehyde and UV-B in Arabidopsis.	Formaldehyde	69-81	GroES-like zinc-binding dehydrogenase family protein	Arabidopsis thaliana	0-4
34919280-4	2022	Although the ADH2/GSNOR1 enzyme can act on different substrates, notably on S-hydroxymethylglutathione (HMG) and S-nitrosoglutathione (GSNO), our study provides several lines of evidence that the sensitivity of gsnor1 to UV-B is caused mainly by UV-B-induced formaldehyde accumulation rather than other factors such as alteration of the GSNO concentration.	Formaldehyde	259-271	GroES-like zinc-binding dehydrogenase family protein	Arabidopsis thaliana	13-17
34919280-5	2022	Our results demonstrate an interplay between formaldehyde and UV-B that exacerbates genome instability, leading to severe DNA damage and impaired growth and development in Arabidopsis, and show that ADH2/GSNOR1 is a key player in combating these effects.	Formaldehyde	45-57	GroES-like zinc-binding dehydrogenase family protein	Arabidopsis thaliana	199-203
34962779-6	2022	We further identified the age-dependent loss of catabolism enzymes ALDH2 and ADH5 as the primary mechanism responsible for formaldehyde excess.	Formaldehyde	123-135	aldehyde dehydrogenase 2, mitochondrial	Mus musculus	67-72
34962779-6	2022	We further identified the age-dependent loss of catabolism enzymes ALDH2 and ADH5 as the primary mechanism responsible for formaldehyde excess.	Formaldehyde	123-135	alcohol dehydrogenase 5 (class III), chi polypeptide	Mus musculus	77-81
34962779-7	2022	Activating ALDH2 with the small molecular activator Alda1 significantly protected neurovascular cells from formaldehyde overload and consequently from impairment during AD progress both in vitro and in vivo.	Formaldehyde	107-119	aldehyde dehydrogenase 2, mitochondrial	Mus musculus	11-16
19515068-3	2009	In mice, mS100A9p inhibited thermal and mechanical hyperalgesia and allodynia induced by either carrageenan or formalin, without interfering with paw edema.	Formaldehyde	111-119	S100 calcium binding protein A9 (calgranulin B)	Mus musculus	9-17
19515068-4	2009	mS100A9p also inhibited myeloperoxidase activity (MPO), a marker of granulocyte infiltration, induced by carrageenan, but increased MPO after formalin intraplantar injection.	Formaldehyde	142-150	S100 calcium binding protein A9 (calgranulin B)	Mus musculus	0-8
34817121-5	2022	The 2-(benzofuran-2-yl)vinyl (BFV) moiety attached at the C8 position of the nucleobase adopted a syn conformation about the glycosidic bond, which facilitated the self-assembly process through the formation of a G-tetrad as the basic unit.	Formaldehyde	30-33	synemin	Homo sapiens	98-101
34732853-3	2022	RAD51 foci were quantified in formalin-fixed, paraffin-embedded untreated tumour specimens by immunofluorescence and the messenger RNA expression of 21 DNA repair genes by real-time PCR.	Formaldehyde	30-38	RAD51 recombinase	Homo sapiens	0-5
34812576-5	2022	Fmr1-KO mice were hyposensitive to mechanical stimuli and intraplantar injections of capsaicin and formalin.	Formaldehyde	99-107	fragile X messenger ribonucleoprotein 1	Mus musculus	0-4
34980577-7	2021	METHODS: We used clinically-validated IHC assays to assess the expression of hMLH1, hMSH2, hMSH6, and/or hPMS2 in formalin-fixed paraffin-embedded tissue sections of bone marrow core biopsies from patients diagnosed with AML.	Formaldehyde	114-122	mutL homolog 1	Homo sapiens	77-82
34934106-3	2021	In anaesthetized rat, microinjection of L-733,060, an antagonist at NK1Rs, into MS antagonized the suppression of CA1 population spike (PS) evoked on peripheral injection of formalin or on intraseptal microinjection of substance P (SP), an agonist at NK1Rs.	Formaldehyde	174-182	carbonic anhydrase 1	Rattus norvegicus	114-117
34904278-3	2022	In the present study, formalin-induced inflammatory pain, mechanical allodynia and thermal hyperalgesia was measured using Efnb3 mutant mice (Efnb3-/- ) and wild-type (Efnb3+/+ ) mice.	Formaldehyde	22-30	ephrin B3	Mus musculus	123-128
34904278-3	2022	In the present study, formalin-induced inflammatory pain, mechanical allodynia and thermal hyperalgesia was measured using Efnb3 mutant mice (Efnb3-/- ) and wild-type (Efnb3+/+ ) mice.	Formaldehyde	22-30	ephrin B3	Mus musculus	142-147
34904278-3	2022	In the present study, formalin-induced inflammatory pain, mechanical allodynia and thermal hyperalgesia was measured using Efnb3 mutant mice (Efnb3-/- ) and wild-type (Efnb3+/+ ) mice.	Formaldehyde	22-30	ephrin B3	Mus musculus	168-173
34980577-7	2021	METHODS: We used clinically-validated IHC assays to assess the expression of hMLH1, hMSH2, hMSH6, and/or hPMS2 in formalin-fixed paraffin-embedded tissue sections of bone marrow core biopsies from patients diagnosed with AML.	Formaldehyde	114-122	PMS1 homolog 2, mismatch repair system component	Homo sapiens	105-110
34799988-0	2022	Response to clinical evaluation of the effectiveness of fusion-induced asymmetric transcription assay-based reverse transcription droplet digital PCR for ALK detection in formalin-fixed paraffin-embedded samples from lung cancer.	Formaldehyde	171-179	ALK receptor tyrosine kinase	Homo sapiens	154-157
34894899-5	2022	Positive immunolabeling for CPA3 was observed in nonneoplastic mast cells in 20/20 formalin-fixed paraffin-embedded normal tissues (skin, liver, spleen, intestine), and in 63/63 MCTs irrespective of their histological grade.	Formaldehyde	83-91	carboxypeptidase A3	Canis lupus familiaris	28-32
34821892-1	2021	We designed and synthesized a fatty aldehyde surrogate containing a formyl thioester group, which can be reduced by fatty aldehyde reductase (FALR) with stoichiometric formaldehyde generation.	Formaldehyde	168-180	aldo-keto reductase family 1 member A1	Homo sapiens	122-140
34787998-0	2021	Carbon Nanotube-Based Field-Effect Transistor-Type Sensor with a Sensing Gate for Ppb-Level Formaldehyde Detection.	Formaldehyde	92-104	histatin 1	Homo sapiens	82-85
34875997-1	2021	BACKGROUND: Esterase D (ESD) is a nonspecific esterase that detoxifies formaldehyde.	Formaldehyde	71-83	esterase D	Gallus gallus	12-22
34396700-0	2021	Formaldehyde-crosslinked nontoxic A beta monomer to form the toxic A beta dimers and aggregates: Pathogenicity and therapeutic perspectives.	Formaldehyde	0-12	amyloid beta precursor protein	Homo sapiens	67-73
34227915-3	2021	We used the immunohistochemical staining to evaluate Stabilin-2 protein expression in formalin-fixed paraffin-embedded tissue of NSCLC patients" primary lesion.	Formaldehyde	86-94	stabilin 2	Homo sapiens	53-63
34850903-6	2022	We, herein, suggest the adoption of correlative light and electron microscopy, that combines confocal laser scanning microscopy and scanning electron microscopy, as the method allowing us to identify the HAP1-positive STBs in formalin-fixed paraffin-embedded (FFPE) sections.	Formaldehyde	226-234	huntingtin-associated protein 1	Mus musculus	204-208
34819667-5	2021	Mice deficient in formaldehyde clearance (Adh5-/-) and CSB (Csbm/m; Csb is also known as Ercc6) develop cachexia and neurodegeneration, and succumb to kidney failure, features that resemble human Cockayne syndrome.	Formaldehyde	18-30	alcohol dehydrogenase 5 (class III), chi polypeptide	Mus musculus	42-46
34819667-6	2021	Using single-cell RNA sequencing, we find that formaldehyde-driven transcriptional stress stimulates the expression of the anorexiogenic peptide GDF15 by a subset of kidney proximal tubule cells.	Formaldehyde	47-59	growth differentiation factor 15	Homo sapiens	145-150
34634683-2	2021	The purpose of this study is to find a suitable immunohistochemical marker for the assessment of suffering to be routinely used in Veterinary Forensic Pathology, by analyzing the expression of Corticotropin-releasing factor (CRF) in formalin-fixed brains of dogs as a measurement of the agonic stress.	Formaldehyde	233-241	corticotropin releasing hormone	Canis lupus familiaris	193-223
34842456-2	2022	Methods: SNORD83A was selected based on databases and further verified in 48 paired formalin-fixed, paraffin-embedded tissues, as well as in plasma from 150 NSCLC patients and 150 healthy donors.	Formaldehyde	84-92	small nucleolar RNA, C/D box 83A	Homo sapiens	9-17
34884678-6	2021	The methylation profiles of LEP were measured in 63 formalin-fixed, paraffin-embedded tumor tissues by quantitative polymerase chain reaction using a MethyLight assay.	Formaldehyde	52-60	leptin	Homo sapiens	28-31
34396700-4	2021	Recently, age-associated formaldehyde and Abeta-derived formaldehyde have been found to crosslink the nontoxic Abeta monomer to form the toxic dimers, oligomers and fibrils.	Formaldehyde	25-37	amyloid beta precursor protein	Homo sapiens	111-116
34396700-4	2021	Recently, age-associated formaldehyde and Abeta-derived formaldehyde have been found to crosslink the nontoxic Abeta monomer to form the toxic dimers, oligomers and fibrils.	Formaldehyde	56-68	amyloid beta precursor protein	Homo sapiens	42-47
34396700-4	2021	Recently, age-associated formaldehyde and Abeta-derived formaldehyde have been found to crosslink the nontoxic Abeta monomer to form the toxic dimers, oligomers and fibrils.	Formaldehyde	56-68	amyloid beta precursor protein	Homo sapiens	111-116
34396700-5	2021	Particularly, Abeta-induced formaldehyde accumulation and formaldehyde-promoted Abeta aggregation form a vicious cycle.	Formaldehyde	28-40	amyloid beta precursor protein	Homo sapiens	14-19
34396700-5	2021	Particularly, Abeta-induced formaldehyde accumulation and formaldehyde-promoted Abeta aggregation form a vicious cycle.	Formaldehyde	58-70	amyloid beta precursor protein	Homo sapiens	14-19
33980374-0	2021	UV Light Activated Multi-Cycle Photoelectric Properties of TiO2 and CdS/TiO 2 Films in Formaldehyde.	Formaldehyde	87-99	CDP-diacylglycerol synthase 1	Homo sapiens	68-71
34877472-9	2021	We further demonstrate that these antibodies recognize the AREG neo-epitope in formalin-fixed, paraffin-embedded tumor tissue, suggesting their utility as a companion diagnostic for patient selection.	Formaldehyde	79-87	amphiregulin	Homo sapiens	59-63
34827627-3	2021	Here we used combination of formaldehyde-induced cross-linking followed by immunoprecipitation and liquid chromatography-tandem mass spectrometry (LC-MS/MS) to elucidate the interaction network of MBP in mammalian cells and provide the list of potential MBP interacting proteins.	Formaldehyde	28-40	myelin basic protein	Homo sapiens	197-200
34827627-3	2021	Here we used combination of formaldehyde-induced cross-linking followed by immunoprecipitation and liquid chromatography-tandem mass spectrometry (LC-MS/MS) to elucidate the interaction network of MBP in mammalian cells and provide the list of potential MBP interacting proteins.	Formaldehyde	28-40	myelin basic protein	Homo sapiens	254-257
34727325-0	2022	Lower Formalin-Induced Pain Responses in Painless Diabetic Neuropathy Rat Correlate with the Reduced Spinal Cord NR2B Subunit of N-Methyl-D-Aspartate Receptor Activation.	Formaldehyde	6-14	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	113-117
34727325-10	2022	In conclusion, reduced pain behavior responses in painless DN rats following formalin injection is possibly contributed by the reduced expression of phosphorylated and total NR2B subunit in the spinal cord.	Formaldehyde	77-85	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	174-178
34326027-2	2021	Our study aims to assess p16 IHC staining in formalin-fixed cytology cell blocks (CBs) from head and neck squamous cell carcinoma (HNSCC) fine-needle aspiration (FNA) specimens in comparison with surgical pathology p16 staining and to determine the reproducibility of p16 IHC scoring in CBs.	Formaldehyde	45-53	cyclin dependent kinase inhibitor 2A	Homo sapiens	25-28
34338322-1	2021	Studies have verified that Fragile X mental retardation protein (FMRP), an RNA-binding protein, plays a potential role in the pathogenesis of formalin- and (RS)-3,5-dihydroxyphenylglycine (DHPG)-induced abnormal pain sensations.	Formaldehyde	142-150	fragile X messenger ribonucleoprotein 1	Rattus norvegicus	27-63
33980374-1	2021	In this work, UV light activated multi-cycle photoelectric properties of TiO2 and CdS/TiO2 films in formaldehyde were researched.	Formaldehyde	100-112	CDP-diacylglycerol synthase 1	Homo sapiens	82-85
34338322-1	2021	Studies have verified that Fragile X mental retardation protein (FMRP), an RNA-binding protein, plays a potential role in the pathogenesis of formalin- and (RS)-3,5-dihydroxyphenylglycine (DHPG)-induced abnormal pain sensations.	Formaldehyde	142-150	fragile X messenger ribonucleoprotein 1	Rattus norvegicus	65-69
34829293-3	2021	PXR protein expression was assessed immunohistochemically on formalin fixed paraffin-embedded breast invasive carcinoma tissue sections, obtained from 148 patients, and was correlated with clinicopathological parameters, molecular phenotypes, tumor cells" proliferative capacity, and overall disease-free patients" survival.	Formaldehyde	61-69	nuclear receptor subfamily 1 group I member 2	Homo sapiens	0-3
34705880-4	2021	Immunohistochemistry technique was used to detect the expressions of p16 and TOP2A proteins from the retrieved formalin-fixed and paraffin-embedded (FFPE) cervical biopsies.	Formaldehyde	111-119	cyclin dependent kinase inhibitor 2A	Homo sapiens	69-72
34705880-4	2021	Immunohistochemistry technique was used to detect the expressions of p16 and TOP2A proteins from the retrieved formalin-fixed and paraffin-embedded (FFPE) cervical biopsies.	Formaldehyde	111-119	DNA topoisomerase II alpha	Homo sapiens	77-82
34812306-0	2021	An Autopsy Case of Idiopathic Rhabdomyolysis in 1979: Immunoperoxidase Detection of Myoglobin Casts in Formalin-Fixed, Paraffin-Embedded Sections of the Kidney.	Formaldehyde	103-111	myoglobin	Homo sapiens	84-93
34224765-5	2021	Local peripheral or intrathecal pre-treatment with BL-1249, selective opener of TREK-1, decreased long-lasting secondary mechanical allodynia and hyperalgesia induced by formalin.	Formaldehyde	170-178	potassium two pore domain channel subfamily K member 2	Rattus norvegicus	80-86
34339771-6	2021	Formalin inactivated unadjuvanted vaccine elicited a balanced IgG1 type and IgG2a type antibody indicating a more balanced Th2/Th1 type immune response while alum formulated formalin inactivated antigen elicited significantly high IgG1 antibody in immunized sera and Th2 cytokines in mice splenocytes denoting Th2 type T cell immune response.	Formaldehyde	0-8	LOC105243590	Mus musculus	62-66
34339771-6	2021	Formalin inactivated unadjuvanted vaccine elicited a balanced IgG1 type and IgG2a type antibody indicating a more balanced Th2/Th1 type immune response while alum formulated formalin inactivated antigen elicited significantly high IgG1 antibody in immunized sera and Th2 cytokines in mice splenocytes denoting Th2 type T cell immune response.	Formaldehyde	0-8	immunoglobulin heavy variable V1-9	Mus musculus	76-81
34339771-6	2021	Formalin inactivated unadjuvanted vaccine elicited a balanced IgG1 type and IgG2a type antibody indicating a more balanced Th2/Th1 type immune response while alum formulated formalin inactivated antigen elicited significantly high IgG1 antibody in immunized sera and Th2 cytokines in mice splenocytes denoting Th2 type T cell immune response.	Formaldehyde	174-182	LOC105243590	Mus musculus	231-235
34310047-6	2021	We employ the alcohol dehydrogenase (ADH) and coenzyme I (NAD + ) for methanol catalytic dehydrogenation at low temperature, which could generate formaldehyde and reductive coenzyme I (NADH).	Formaldehyde	146-158	aldo-keto reductase family 1 member A1	Homo sapiens	14-35
34310047-6	2021	We employ the alcohol dehydrogenase (ADH) and coenzyme I (NAD + ) for methanol catalytic dehydrogenation at low temperature, which could generate formaldehyde and reductive coenzyme I (NADH).	Formaldehyde	146-158	aldo-keto reductase family 1 member A1	Homo sapiens	37-40
34308375-4	2021	Here we describe an optimized protocol for immunostaining of ACE2 in formalin fixed paraffin embedded human (FFPE) pancreas, small intestine and kidney tissue sections obtained from organ donors and autopsies.	Formaldehyde	69-77	angiotensin converting enzyme 2	Homo sapiens	61-65
34681666-4	2021	Performing mIHC on formalin-fixed paraffin-embedded (FFPE) mouse tissues, particularly with sensitive antigens, remain challenging.	Formaldehyde	19-27	myosin IA	Mus musculus	11-15
34526111-10	2021	Col11a1a within formalin-fixed paraffin-embedded zebrafish were recognized by the antibody.	Formaldehyde	16-24	collagen, type XI, alpha 1a	Danio rerio	0-8
34224765-0	2021	TREK-1 potassium channels participate in acute and long-lasting nociceptive hypersensitivity induced by formalin in rats.	Formaldehyde	104-112	potassium two pore domain channel subfamily K member 2	Rattus norvegicus	0-6
34224765-3	2021	The aim of this study was to investigate the local peripheral and spinal participation of TREK-1 in formalin-induced acute and long-lasting nociceptive hypersensitivity.	Formaldehyde	100-108	potassium two pore domain channel subfamily K member 2	Rattus norvegicus	90-96
34224765-7	2021	Pre-treatment with two recombinant channels that produce a high TREK-1 current, S300A and S333A (non-phosphorylated state of TREK-1), reduced formalin-induced acute pain and long-lasting mechanical allodynia and hyperalgesia.	Formaldehyde	142-150	potassium two pore domain channel subfamily K member 2	Rattus norvegicus	64-70
34224765-7	2021	Pre-treatment with two recombinant channels that produce a high TREK-1 current, S300A and S333A (non-phosphorylated state of TREK-1), reduced formalin-induced acute pain and long-lasting mechanical allodynia and hyperalgesia.	Formaldehyde	142-150	potassium two pore domain channel subfamily K member 2	Rattus norvegicus	125-131
34224765-9	2021	Formalin increased TREK-1 expression at 1 and 6 days in DRG and dorsal spinal cord in rats, whereas that it increased c-fos expression at the DRG.	Formaldehyde	0-8	potassium two pore domain channel subfamily K member 2	Rattus norvegicus	19-25
34224765-9	2021	Formalin increased TREK-1 expression at 1 and 6 days in DRG and dorsal spinal cord in rats, whereas that it increased c-fos expression at the DRG.	Formaldehyde	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	118-123
34224765-10	2021	Intrathecal repeated transfection of rats with S300A and S333A or injection with BL-1249 reduced formalin-induced enhanced c-fos expression.	Formaldehyde	97-105	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	123-128
34224765-11	2021	Data suggest that TREK-1 activity at peripheral and spinal sites reduces neuronal excitability in the process of acute and long-lasting nociception induced by formalin in rats.	Formaldehyde	159-167	potassium two pore domain channel subfamily K member 2	Rattus norvegicus	18-24
34382102-5	2021	RESULTS: Individual pretreatments of rats with montelukast, diclofenac, or celecoxib partly reduced formalin-induced increases in (i) paw edema, fibrosis, and inflammatory cells, (iii) serum interleukin-6 (IL-6) and leukotrienes (LTB4 and LTD4), and (iv) paw expressions of inducible nitric oxide synthase (iNOS) and COX2.	Formaldehyde	100-108	interleukin 6	Rattus norvegicus	191-204
34265366-6	2021	Combined with bioinformatics analysis, the rno-miR-449a-5p was predicted and verified that its expression decreased in the testis exposed to formaldehyde.	Formaldehyde	141-153	microRNA 449a	Rattus norvegicus	43-55
34382102-5	2021	RESULTS: Individual pretreatments of rats with montelukast, diclofenac, or celecoxib partly reduced formalin-induced increases in (i) paw edema, fibrosis, and inflammatory cells, (iii) serum interleukin-6 (IL-6) and leukotrienes (LTB4 and LTD4), and (iv) paw expressions of inducible nitric oxide synthase (iNOS) and COX2.	Formaldehyde	100-108	interleukin 6	Rattus norvegicus	206-210
34382102-5	2021	RESULTS: Individual pretreatments of rats with montelukast, diclofenac, or celecoxib partly reduced formalin-induced increases in (i) paw edema, fibrosis, and inflammatory cells, (iii) serum interleukin-6 (IL-6) and leukotrienes (LTB4 and LTD4), and (iv) paw expressions of inducible nitric oxide synthase (iNOS) and COX2.	Formaldehyde	100-108	nitric oxide synthase 2	Rattus norvegicus	274-305
34382102-5	2021	RESULTS: Individual pretreatments of rats with montelukast, diclofenac, or celecoxib partly reduced formalin-induced increases in (i) paw edema, fibrosis, and inflammatory cells, (iii) serum interleukin-6 (IL-6) and leukotrienes (LTB4 and LTD4), and (iv) paw expressions of inducible nitric oxide synthase (iNOS) and COX2.	Formaldehyde	100-108	nitric oxide synthase 2	Rattus norvegicus	307-311
34382102-5	2021	RESULTS: Individual pretreatments of rats with montelukast, diclofenac, or celecoxib partly reduced formalin-induced increases in (i) paw edema, fibrosis, and inflammatory cells, (iii) serum interleukin-6 (IL-6) and leukotrienes (LTB4 and LTD4), and (iv) paw expressions of inducible nitric oxide synthase (iNOS) and COX2.	Formaldehyde	100-108	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	317-321
34382102-7	2021	Alternatively, montelukast or celecoxib, but not diclofenac, alleviated formalin-evoked gastric damage and increments in tumor necrosis factor-alpha and decrements in prostaglandin-E2.	Formaldehyde	72-80	tumor necrosis factor	Rattus norvegicus	121-148
34364401-5	2021	HSPD1 expression was evaluated by immunohistochemistry from formalin-fixed paraffin-embedded tissues from NSCLC patients.	Formaldehyde	60-68	heat shock protein family D (Hsp60) member 1	Homo sapiens	0-5
34312925-4	2021	CCT6A protein expression was determined in the tumor tissues fixed in formalin and embedded in paraffin (FFEP) by immunohistochemistry (IHC) assay.	Formaldehyde	70-78	chaperonin containing TCP1 subunit 6A	Homo sapiens	0-5
34512747-3	2021	We previously found that the activation of microglial glucagon-like peptide 1 receptor (GLP-1R) could potently relieve formalin-, bone cancer-, peripheral nerve injury-, and diabetes-induced pain hypersensitivity.	Formaldehyde	119-127	glucagon like peptide 1 receptor	Homo sapiens	54-86
34512747-3	2021	We previously found that the activation of microglial glucagon-like peptide 1 receptor (GLP-1R) could potently relieve formalin-, bone cancer-, peripheral nerve injury-, and diabetes-induced pain hypersensitivity.	Formaldehyde	119-127	glucagon like peptide 1 receptor	Homo sapiens	88-94
34318819-2	2021	Here, through an initial pretreatment of N-heteroarenes with alkyl bromide, we describe a syn-selective construction of functional fused heterocycles via iridium catalyzed reductive annulation of N-heteroarenium salts with formaldehyde and cyclic 1,3-diketones or 4-hydroxycoumarins, proceeding with broad substrate scope, good functional group compatibility, readily available feedstocks, and high step and atom efficiency.	Formaldehyde	223-235	synemin	Homo sapiens	90-93
34733484-1	2021	This study investigated the hemato- and genotoxic effects of formaldehyde (FA) and the possible mitigating role of hesperidin (HP) and N-acetylcysteine (NAC), each alone and in combination.	Formaldehyde	61-73	glycogen synthase kinase 3 beta	Rattus norvegicus	75-77
34413463-4	2021	The activation of semicarbazide-sensitive amine oxidase and sarcosine dehydrogenase induced by HU-stress contributed to formaldehyde generation and loss of the abilities to maintain balance and coordinate motor activities.	Formaldehyde	120-132	amine oxidase, copper containing 3	Mus musculus	18-55
34413463-5	2021	Further, knockout of formaldehyde dehydrogenase (FDH-/-) in mice caused formaldehyde accumulation in the muscle and cerebellum that was associated with motor deficits.	Formaldehyde	21-33	alcohol dehydrogenase 5 (class III), chi polypeptide	Mus musculus	49-52
34413463-5	2021	Further, knockout of formaldehyde dehydrogenase (FDH-/-) in mice caused formaldehyde accumulation in the muscle and cerebellum that was associated with motor deficits.	Formaldehyde	72-84	alcohol dehydrogenase 5 (class III), chi polypeptide	Mus musculus	49-52
34097781-1	2021	Herein, we report a KIO 4 -mediated, sustainable and chemoselective approach for the one-pot C3( sp 2 )-H bond hydroxymethylation or methylenation of imidazo-heteroarenes with formaldehyde, generated in situ via the oxidative cleavage of ethylene glycol or glycerol (renewable reagents) through the Malaprade reaction.	Formaldehyde	176-188	Sp2 transcription factor	Homo sapiens	97-101
34400544-3	2021	The Idylla EGFR mutation test (IEMT) has been specifically designed to process formalin-fixed paraffin-embedded sections without requiring preliminary DNA extraction.This study aims to evaluate the diagnostic accuracy of IEMT when used to analyse archival histopathology material.	Formaldehyde	79-87	epidermal growth factor receptor	Homo sapiens	11-15
34318802-1	2021	An "AND"-logic-gate-based fluorescent probe NAP-DCP-4 with dual reactive sites is reported, which has improved selectivity for methylglyoxal over glyoxal, featuring formaldehyde-enhanced methylglyoxal detection and irreversible and reversible turn-on fluorescence responses at different excitation wavelengths.	Formaldehyde	165-177	catenin beta like 1	Homo sapiens	44-47
34456727-6	2021	SMG9 protein expression was analyzed in ninety-five sets of paired formalin-fixed and paraffin-embedded tissue specimens by immunohistochemistry (IHC).	Formaldehyde	67-75	SMG9 nonsense mediated mRNA decay factor	Homo sapiens	0-4
34393539-6	2021	Methods: Immunohistochemistry was used to characterise glypican-6 expression in a panel of archived formalin-fixed, paraffin-embedded colon tissue types.	Formaldehyde	100-108	glypican 6	Homo sapiens	55-65
34437496-0	2021	Formaldehyde in Hospitals Induces Oxidative Stress: The Role of GSTT1 and GSTM1 Polymorphisms.	Formaldehyde	0-12	glutathione S-transferase theta 1	Homo sapiens	64-69
34362389-7	2021	Immunohistochemistry (IHC) staining was performed to evaluate the expression of NAT10 in formalin fixed paraffin-embedded (FFPE) samples of HNSCC.	Formaldehyde	89-97	N-acetyltransferase 10	Homo sapiens	80-85
34297545-1	2021	Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) is an established tool for the investigation of formalin-fixed paraffin-embedded (FFPE) tissue samples and shows a high potential for applications in clinical research and histopathological tissue classification.	Formaldehyde	130-138	RB binding protein 4, chromatin remodeling factor	Homo sapiens	77-80
34752207-0	2021	Circular RNA-CDR1as is involved in lung injury induced by long-term formaldehyde inhalation.	Formaldehyde	68-80	cerebellar degeneration related protein 1	Homo sapiens	13-17
34289525-1	2021	We previously reported the usefulness of droplet digital polymerase chain reaction (ddPCR) for the assessment of Human epithelial growth factor receptor 2 (HER2) gene amplification in breast cancer using formalin-fixed and paraffin-embedded sections.	Formaldehyde	204-212	erb-b2 receptor tyrosine kinase 2	Homo sapiens	156-160
34363210-6	2021	EXPERIMENTAL APPROACH: Light-dependent activity of pc-Mor was assessed in cell-based assays (intracellular calcium accumulation and electrophysiology) and in mice (formalin animal model of pain).	Formaldehyde	164-172	opioid receptor, mu 1	Mus musculus	54-57
34089806-4	2021	METHODS: For clinical validation, we compared the performance of dPCR and castPCR in 57 NSCL formalin fixed paraffin embedded samples and 10 lung cancer-free formalin fixed paraffin embedded samples.	Formaldehyde	93-101	nescient helix-loop-helix 1	Homo sapiens	88-92
34437496-0	2021	Formaldehyde in Hospitals Induces Oxidative Stress: The Role of GSTT1 and GSTM1 Polymorphisms.	Formaldehyde	0-12	glutathione S-transferase mu 1	Homo sapiens	74-79
34437496-6	2021	In the formalin-employers group we assessed significantly higher levels of 15-F2t-IsoP, MDA and TNFalpha (<0.001) in comparison to the non-employers group.	Formaldehyde	7-15	tumor necrosis factor	Homo sapiens	96-104
34437496-8	2021	In the formalin-employers group the MDA level was significantly higher in GSTT1 Null (p = 0.038), GSTM1 Null (p = 0.031), and CYP1A1 exon 7 mutation carrier (p = 0.008) workers, compared to the wild type subjects.	Formaldehyde	7-15	glutathione S-transferase theta 1	Homo sapiens	74-79
34437496-8	2021	In the formalin-employers group the MDA level was significantly higher in GSTT1 Null (p = 0.038), GSTM1 Null (p = 0.031), and CYP1A1 exon 7 mutation carrier (p = 0.008) workers, compared to the wild type subjects.	Formaldehyde	7-15	glutathione S-transferase mu 1	Homo sapiens	98-103
34437496-8	2021	In the formalin-employers group the MDA level was significantly higher in GSTT1 Null (p = 0.038), GSTM1 Null (p = 0.031), and CYP1A1 exon 7 mutation carrier (p = 0.008) workers, compared to the wild type subjects.	Formaldehyde	7-15	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	126-132
34300636-3	2021	In the cascade reaction, oxidation of MeOH was initially catalyzed by AOD to produce formaldehyde, and then this formaldehyde was successively oxidized via FALDH catalysis together with reduction of oxidized form of beta-nicotinamide adenine dinucleotide (NAD+).	Formaldehyde	113-125	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	156-161
34136904-0	2021	Quantification of Human Epidermal Growth Factor Receptor 2 by Immunopeptide Enrichment and Targeted Mass Spectrometry in Formalin-Fixed Paraffin-Embedded and Frozen Breast Cancer Tissues.	Formaldehyde	121-129	erb-b2 receptor tyrosine kinase 2	Homo sapiens	24-58
34377990-4	2021	Formalin-fixed paraffin-embedded tumor samples underwent polymerase chain reaction assay to detect MYD88 mutation.	Formaldehyde	0-8	MYD88 innate immune signal transduction adaptor	Homo sapiens	99-104
34136904-3	2021	We evaluated the analytical performance of a targeted mass spectrometry-based assay for quantifying HER2 protein in formalin-fixed paraffin-embedded (FFPE) and frozen BC biopsies.	Formaldehyde	116-124	erb-b2 receptor tyrosine kinase 2	Homo sapiens	100-104
34206205-4	2021	METHODS: We compared PD-L1 expression in patient-matched frozen (FR) and formalin-fixed paraffin-embedded (FFPE) tissues of breast cancer patients.	Formaldehyde	73-81	CD274 molecule	Homo sapiens	21-26
34447537-3	2021	Halogen-atom transfer (XAT) from alpha-aminoalkyl radicals is leveraged to convert the iodide into the corresponding open-shell species, while its following addition to formaldehyde is rendered irreversible by trapping the transient O-radical with PPh3.	Formaldehyde	169-181	caveolin 1	Homo sapiens	248-252
34128111-6	2021	In this report, we described a novel droplet digital PCR (ddPCR) assay to evaluate TERT hot spot mutations in fresh frozen and formalin-fixed paraffin-embedded (FFPE) specimens of glioma and verified the difference in results from the Sanger DNA sequencing results.	Formaldehyde	127-135	telomerase reverse transcriptase	Homo sapiens	83-87
34187953-3	2021	This study determined whether rapamycin, an mTOR inhibitor, reduces nociceptive responses and the number of Fos-immunoreactive (Fos-ir) cells in the trigeminal nucleus caudalis (TNC) in a mouse orofacial formalin model.	Formaldehyde	204-212	FBJ osteosarcoma oncogene	Mus musculus	108-111
34799331-5	2021	Correspondingly, enzyme linked immunosorbent assay was performed for the estimation of prostaglandins E2 (PGE2) and tumor necrosis factor-alpha (TNF-alpha) in serum of formaldehyde-induced arthritic animals.	Formaldehyde	168-180	tumor necrosis factor	Homo sapiens	116-143
34799331-5	2021	Correspondingly, enzyme linked immunosorbent assay was performed for the estimation of prostaglandins E2 (PGE2) and tumor necrosis factor-alpha (TNF-alpha) in serum of formaldehyde-induced arthritic animals.	Formaldehyde	168-180	tumor necrosis factor	Homo sapiens	145-154
34276540-2	2021	The purpose of this study was to correlate quantification of autoradiography signal using the novel next-generation tau positron emission tomography (PET) radiotracer (18F)PI-2620 with immunohistochemically determined tau-protein load in both formalin-fixed paraffin-embedded (FFPE) and frozen tissue samples of patients with Alzheimer"s disease (AD) and Progressive Supranuclear Palsy (PSP).	Formaldehyde	243-251	microtubule associated protein tau	Homo sapiens	116-119
34276540-2	2021	The purpose of this study was to correlate quantification of autoradiography signal using the novel next-generation tau positron emission tomography (PET) radiotracer (18F)PI-2620 with immunohistochemically determined tau-protein load in both formalin-fixed paraffin-embedded (FFPE) and frozen tissue samples of patients with Alzheimer"s disease (AD) and Progressive Supranuclear Palsy (PSP).	Formaldehyde	243-251	microtubule associated protein tau	Homo sapiens	218-221
34094537-8	2021	In the formalin test, PA-Int5 (at 2.5 and 5 mg/kg) reduced nociception in the second phase.	Formaldehyde	7-15	integrator complex subunit 5	Mus musculus	25-29
34174041-5	2022	In this study, we found about 70% of pERK-positive neurons colocalized with PKCdelta+ neurons in the formalin-induced pain model in mice.	Formaldehyde	101-109	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	37-41
34174041-5	2022	In this study, we found about 70% of pERK-positive neurons colocalized with PKCdelta+ neurons in the formalin-induced pain model in mice.	Formaldehyde	101-109	protein kinase C, delta	Mus musculus	76-84
34226497-4	2021	In the FFPE (formalin-fixed paraffin-embedded) sections prepared from the colons of ulcerative colitis (UC) and immune-mediated colitis (IRAEC) patients, expression of DCLK1 isoforms correlated positively with Notch1 and negatively with a transcriptional repressor, FoxD3 (Forkhead Box D3).	Formaldehyde	13-21	doublecortin like kinase 1	Homo sapiens	168-173
34239653-7	2021	Maltoamide F (1 mg/kg, 5 mg/kg, and 10 mg/kg) reduced levels of PGE-2, IL-6, and TNF-alpha in foot tissues of formalin-induced rats.	Formaldehyde	110-118	interleukin 6	Rattus norvegicus	71-75
34239653-7	2021	Maltoamide F (1 mg/kg, 5 mg/kg, and 10 mg/kg) reduced levels of PGE-2, IL-6, and TNF-alpha in foot tissues of formalin-induced rats.	Formaldehyde	110-118	tumor necrosis factor	Rattus norvegicus	81-90
34080894-3	2021	Confocal microscopy/immunofluorescence on cultures fixed with neutral-buffered 10% formalin (NBF) revealed cytoplasmic HAS2 in HUVEC cords and tubes.	Formaldehyde	83-91	hyaluronan synthase 2	Homo sapiens	119-123
34178624-3	2021	Materials and Methods: We verify a co-expression of BRAF V600E mutation and PD-L1 high expression more than 50% on formalin-fixed paraffin-embedded tumor sample of a newly diagnosed lung adenocarcinoma patient by immunohistochemistry and BRAF V600E/EGFR/ALK/ROS1 Mutations Detection Kit.	Formaldehyde	115-123	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	52-56
34178624-3	2021	Materials and Methods: We verify a co-expression of BRAF V600E mutation and PD-L1 high expression more than 50% on formalin-fixed paraffin-embedded tumor sample of a newly diagnosed lung adenocarcinoma patient by immunohistochemistry and BRAF V600E/EGFR/ALK/ROS1 Mutations Detection Kit.	Formaldehyde	115-123	CD274 molecule	Homo sapiens	76-81
34078054-12	2021	The immunohistochemical analyses of 139 formalin fixed paraffin-embedded samples showed that the low expression of BUB1B was correlated with poor prognosis in TNBC (HR=0.41, 95%CI (0.18-0.95), P=0.024).	Formaldehyde	40-48	BUB1 mitotic checkpoint serine/threonine kinase B	Homo sapiens	115-120
34203855-4	2021	In this study, we further improved and calibrated a previously described RAD51-based functional HRD test on 74 diagnostic formalin-fixed paraffin-embedded (FFPE) specimens (RAD51-FFPE test) from endometrial cancer (EC n = 25) and epithelial ovarian cancer (OC n = 49) patients.	Formaldehyde	122-130	RAD51 recombinase	Homo sapiens	73-78
34116682-5	2021	The type of sample (peripheral blood and formalin-fixed paraffin-embedded tissue) used for testing was significantly associated with the BRAF V600E mutation status (p-value = 0.000 and 0.000).	Formaldehyde	41-49	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	137-141
34064461-7	2021	On the other hand, the formalin-inactivated vaccine improved the survival of fish upon infection without inducing the production of IgM-NNV antibodies and only stimulating the expression of herc4 and mhcii genes (in head-kidney and brain, respectively) during the vaccination period; this suggests that other immune-related pathways may be involved in the partial protection provoked.	Formaldehyde	23-31	HECT and RLD domain containing E3 ubiquitin protein ligase 4	Homo sapiens	190-195
34092577-5	2021	METHODS: The immunohistochemical staining technique was used to show the expression of FBP1 and LDHB in formalin-fixed, paraffin-embedded blocks of 32 fibroadenomas and 31 invasive breast cancer samples.	Formaldehyde	104-112	fructose-bisphosphatase 1	Homo sapiens	87-91
34092612-4	2021	NNAT was detected in formaldehyde fixed, paraffin embedded primary cancer tissue by immunohistochemistry and an immuno-reactive score (IRS) determined.	Formaldehyde	21-33	neuronatin	Homo sapiens	0-4
34092577-5	2021	METHODS: The immunohistochemical staining technique was used to show the expression of FBP1 and LDHB in formalin-fixed, paraffin-embedded blocks of 32 fibroadenomas and 31 invasive breast cancer samples.	Formaldehyde	104-112	lactate dehydrogenase B	Homo sapiens	96-100
34236631-3	2021	This chapter describes how to identify and localize NF-kappaB proteins in human tissue using immunohistochemical staining on formalin-fixed paraffin-embedded and frozen tissue.	Formaldehyde	125-133	nuclear factor kappa B subunit 1	Homo sapiens	52-61
34151850-3	2021	METHODS: Full-length huntingtin with 20 and 140 polyQ repeats were formaldehyde-crosslinked and isolated via their N-terminal Flag-tag from 2-month-old mice brain cortex.	Formaldehyde	67-79	huntingtin	Mus musculus	21-31
34151862-5	2021	Formalin-fixed paraffin-embedded sections were immunohistochemically stained for pSyn, shown to be highly specific and sensitive for alpha-synuclein pathology.	Formaldehyde	0-8	synuclein alpha	Homo sapiens	133-148
34336029-3	2021	Material and methods: Expression levels of LINC-ROR and stemness-related factors: SOX2, NANOG, and POU5F1 were detected in 60 formalin-fixed, paraffin-embedded tissues, and their paired adjacent non-cancer tissues (n = 60) by using real-time qRT-PCR analysis.	Formaldehyde	126-134	long intergenic non-protein coding RNA, regulator of reprogramming	Homo sapiens	43-51
34219079-4	2021	Aldehyde degradation deficiency syndrome (ADDS) is caused by combined defects in two genes, ADH5 and ALDH2, which are both critical for degrading endogenously generated formaldehyde.	Formaldehyde	169-181	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	92-96
34219079-4	2021	Aldehyde degradation deficiency syndrome (ADDS) is caused by combined defects in two genes, ADH5 and ALDH2, which are both critical for degrading endogenously generated formaldehyde.	Formaldehyde	169-181	aldehyde dehydrogenase 2 family member	Homo sapiens	101-106
34732617-6	2021	This disorder is caused by combined inactivating mutations in ADH5 and ALDH2 coding formaldehyde-detoxifying enzymes.	Formaldehyde	84-96	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	62-66
34732617-6	2021	This disorder is caused by combined inactivating mutations in ADH5 and ALDH2 coding formaldehyde-detoxifying enzymes.	Formaldehyde	84-96	aldehyde dehydrogenase 2 family member	Homo sapiens	71-76
35293692-3	2022	As most clinical trials initially required tumor biopsy for PD-L1 detection by IHC, many of the currently available PD-1/PD-L1 assays have been developed and validated on formalin fixed tissue specimens.	Formaldehyde	171-179	CD274 molecule	Homo sapiens	121-126
35504338-4	2022	We found that common protein-damaging agents such as endogenous/exogenous aldehydes (formaldehyde, acetaldehyde), moderate heat shock and the environmental toxicant cadmium cause inactivation of HIF1 and HIF2 due to structural damage to HIFalpha subunits.	Formaldehyde	85-97	hypoxia inducible factor 1 subunit alpha	Homo sapiens	195-199
35581361-0	2022	Formaldehyde exposure induces differentiation of regulatory T cells via the NFAT-mediated T cell receptor signalling pathway in Yucatan minipigs.	Formaldehyde	0-12	transcription factor NFAT	Sus scrofa	76-80
35303234-0	2022	Soluble epoxide hydrolase inhibition avoid formalin-induced inflammatory hyperalgesia in the temporomandibular joint.	Formaldehyde	43-51	epoxide hydrolase 2	Rattus norvegicus	0-25
35468339-0	2022	Distinct expression signatures of miR-130a, miR-301a, miR-454 in formalin fixed paraffin embedded tissue samples of prostate cancer patients.	Formaldehyde	65-73	microRNA 454	Homo sapiens	54-61
35468339-5	2022	Accordingly, in the present study, we aimed to reveal the clinical significance of miR-130a, miR-301a, miR-454 expression levels in formalin fixed paraffin embedded (FFPE) tissue samples of prostate cancer patients.	Formaldehyde	132-140	microRNA 454	Homo sapiens	103-110
35510894-0	2022	A Molten-Salt Method to Synthesize Co9 S8 Embedded, N, S Co-Doped Mesoporous Carbons from Melamine Formaldehyde Resins for Electrocatalytic Hydrogen Evolution Reactions.	Formaldehyde	99-111	phosphoserine phosphatase pseudogene 1	Homo sapiens	35-38
35471961-5	2022	The results showed for the first time that (S)-1-(((R)-2-amino-3-(carboxymethylamino)-3-oxopropylthio)methyl)-5-oxopyrrolidine-2-carboxylic acid (PGF) and thioproline-glycine (SPro-Gly) are major metabolites in both nonenzymatic reactions and formaldehyde-exposed human cells.	Formaldehyde	243-255	placental growth factor	Homo sapiens	146-149
35471961-8	2022	It is anticipated that the findings of this study could shed light on developing PGF and SPro-Gly as dietary supplements and on the development of noninvasive methods to assess health risks associated with formaldehyde exposure.	Formaldehyde	206-218	placental growth factor	Homo sapiens	81-84
35586706-3	2022	Expression of a three-gene signature (IGFBP3, F3, VGLL3) was measured in formalin-fixed paraffin-embedded material from diagnostic core needle biopsies (CNB) of these patients.	Formaldehyde	73-81	insulin like growth factor binding protein 3	Homo sapiens	38-44
35586706-3	2022	Expression of a three-gene signature (IGFBP3, F3, VGLL3) was measured in formalin-fixed paraffin-embedded material from diagnostic core needle biopsies (CNB) of these patients.	Formaldehyde	73-81	vestigial like family member 3	Homo sapiens	50-55
35501334-7	2022	Our data demonstrate that cathepsin K knockout mice (Ctsk-/-) have a reduction in nocifensive behaviors in the formalin test.	Formaldehyde	111-119	cathepsin K	Mus musculus	26-37
35501334-7	2022	Our data demonstrate that cathepsin K knockout mice (Ctsk-/-) have a reduction in nocifensive behaviors in the formalin test.	Formaldehyde	111-119	cathepsin K	Mus musculus	53-57
35379891-5	2022	The network analyses led to the construction of the respiratory system-related biological network associated with formaldehyde exposure, and six upregulated hub genes (AREG, CXCL2, HMOX1, PLAUR, PTGS2, and TIMP1) were identified.	Formaldehyde	114-126	C-X-C motif chemokine ligand 2	Homo sapiens	174-179
35168105-2	2022	In this study, redox and pH dual-responsive nanocarriers (CPNPs) were prepared through molecular assembly by utilizing the Schiff base interactions of cystamine (Cys), PEG-NH2 and formaldehyde (FA) under aqueous conditions with a one-pot, one-step technique.	Formaldehyde	180-192	phenylalanine hydroxylase	Homo sapiens	25-27
35439652-3	2022	In this study we aim to evaluate and validate the utility and reliability of the TERT RNAscope  in-situ hybridization (ISH) assay for the detection of TERT mRNA expression in formalin-fixed, paraffin embedded tissue.	Formaldehyde	175-183	telomerase reverse transcriptase	Homo sapiens	81-85
35439652-3	2022	In this study we aim to evaluate and validate the utility and reliability of the TERT RNAscope  in-situ hybridization (ISH) assay for the detection of TERT mRNA expression in formalin-fixed, paraffin embedded tissue.	Formaldehyde	175-183	telomerase reverse transcriptase	Homo sapiens	151-155
35133686-4	2022	METHODS: ADH expression patterns were characterized by density analysis of ADH immunohistochemistry (n = 21) and real-time RT-PCR of total RNAs by laser-capture microdissection (n = 10) and whole tissue formalin-fixed paraffin embedded prostate biopsies (n = 63).	Formaldehyde	203-211	alcohol dehydrogenase 1A (class I), alpha polypeptide	Homo sapiens	9-12
35561608-4	2022	Using 10% CoP and a ZCS/CoP concentration of 2.5 g L-1, the resulting ZCS/CoP/MWNTs/sponge catalyst exhibited the best catalytic of CO2 reduction ability toward formate (7894.6 mumol L-1) and formaldehyde (308.5 mumol L-1) after 60 min of discharge, respectively.	Formaldehyde	192-204	caspase recruitment domain family member 16	Homo sapiens	74-77
35565309-4	2022	Droplet digital PCR (ddPCR) was used to implement the assessment of HER2 status in formalin-fixed paraffin-embedded (FFPE) tumor DNA from a retrospective cohort (86 patients) and in cell-free DNA (cfDNA) samples from a prospective cohort (28 patients).	Formaldehyde	83-91	erb-b2 receptor tyrosine kinase 2	Homo sapiens	68-72
35462576-3	2022	In our study, high-sensitivity label-free quantitative proteomics analysis revealed nuclear protein 1 (NUPR1) as the most significantly upregulated protein in formalin-fixed paraffin-embedded tumour samples derived from OSCC patients with or without lymphatic metastasis.	Formaldehyde	159-167	nuclear protein 1, transcriptional regulator	Homo sapiens	84-101
35462576-3	2022	In our study, high-sensitivity label-free quantitative proteomics analysis revealed nuclear protein 1 (NUPR1) as the most significantly upregulated protein in formalin-fixed paraffin-embedded tumour samples derived from OSCC patients with or without lymphatic metastasis.	Formaldehyde	159-167	nuclear protein 1, transcriptional regulator	Homo sapiens	103-108
35333330-3	2022	Unlike FTO, ALKBH5 efficiently catalyzes fragmentation of its proposed nascent hemiaminal intermediate to give formaldehyde and a demethylated nucleoside.	Formaldehyde	111-123	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	7-10
35333330-3	2022	Unlike FTO, ALKBH5 efficiently catalyzes fragmentation of its proposed nascent hemiaminal intermediate to give formaldehyde and a demethylated nucleoside.	Formaldehyde	111-123	alkB homolog 5, RNA demethylase	Homo sapiens	12-18
35456960-3	2022	The expression of eEF1A1 protein was determined in formalin-fixed, paraffin-embedded prostate cancer and hyperplasia tissue by IHC.	Formaldehyde	51-59	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	18-24
35151910-6	2022	METHODS: Here, we developed 2 quantifications methods to explore BRCA1 and RAD51C promoter methylation in a series of 121 Formalin Fixed-Paraffin-Embedded (FFPE) specimens from resected PA without neoadjuvant treatment.	Formaldehyde	122-130	BRCA1 DNA repair associated	Homo sapiens	65-70
35151910-6	2022	METHODS: Here, we developed 2 quantifications methods to explore BRCA1 and RAD51C promoter methylation in a series of 121 Formalin Fixed-Paraffin-Embedded (FFPE) specimens from resected PA without neoadjuvant treatment.	Formaldehyde	122-130	RAD51 paralog C	Homo sapiens	75-81
35397317-9	2022	MALAT1-GLI1 fusion was detected in formalin-fixed paraffin-embedded tissue using RT-PCR and Sanger sequencing.	Formaldehyde	35-43	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	0-6
35397317-9	2022	MALAT1-GLI1 fusion was detected in formalin-fixed paraffin-embedded tissue using RT-PCR and Sanger sequencing.	Formaldehyde	35-43	GLI family zinc finger 1	Homo sapiens	7-11
35403870-2	2022	Immunohistochemistry (IHC) on formalin-fixed, paraffin-embedded (FFPE) tumor tissue has an established role in detecting PD-L1 expression and in ALK, ROS1, and more recently NTRK testing.	Formaldehyde	30-38	CD274 molecule	Homo sapiens	121-126
35561608-0	2022	Promoting the reduction of CO2 to formate and formaldehyde via gas-liquid interface dielectric barrier discharge using a Zn0.5Cd0.5S/CoP/multiwalled carbon nanotubes catalyst.	Formaldehyde	46-58	caspase recruitment domain family member 16	Homo sapiens	133-136
35561608-3	2022	The CO2 reduction products (formate and formaldehyde) produced via dielectric barrier discharge (DBD) using the different catalysts proved that the introduction of the CoP nanowires co-catalyst can enhance the catalytic activity of ZCS/MWNTs/sponge in the DBD system.	Formaldehyde	40-52	caspase recruitment domain family member 16	Homo sapiens	168-171
35574323-7	2022	Protein expression of N-CAD was studied in 117 formalin-fixed and paraffin-embedded (FFPE) blocks from patients diagnosed with OC using Tissue Microarray and immunohistochemistry techniques.	Formaldehyde	47-55	cadherin 2	Homo sapiens	22-27
35574415-3	2022	Methods: HER2 protein expression was tested by immunohistochemistry (IHC) in formalin-fixed, paraffin-embedded (FFPE) samples from 4,836 CRC patients in our institution.	Formaldehyde	77-85	erb-b2 receptor tyrosine kinase 2	Homo sapiens	9-13
35528164-6	2022	The expression of SCD1 in 491 formalin-fixed, paraffin-embedded CRC specimens was investigated with immunochemistry.	Formaldehyde	30-38	stearoyl-Coenzyme A desaturase 1	Mus musculus	18-22
35548669-7	2022	While response latencies to noxious heat were unchanged, chemically induced pain-related behavior revealed a reduction of the licking time and an increase in flinching in spastic homozygotes during both phases of the formalin test.	Formaldehyde	217-225	glycine receptor, beta subunit	Mus musculus	171-178
35589508-5	2022	MATERIALS AND METHODS: ICC for PD-L1 was performed on formalin-fixed paraffin-embedded CBs of MPE and patient-matched histologic samples, if available, using the automated Ventana PD-L1 SP263 assay.	Formaldehyde	54-62	CD274 molecule	Homo sapiens	31-36
35459777-3	2022	Therefore, we developed an automated high-throughput mIF workflow for quantitative single-cell level assessment of formalin fixed paraffin embedded tissue (FFPE), leveraging tyramide signal amplification on a Ventana Ultra platform coupled with automated multispectral imaging on a Vectra 3 platform.	Formaldehyde	115-123	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	53-56
35562908-2	2022	High tumor PD-L1 expression, detected by immunohistochemistry (IHC) typically on formalin-fixed paraffin-embedded (FFPE) histological specimens, is linked to better response.	Formaldehyde	81-89	CD274 molecule	Homo sapiens	11-16
35412687-12	2022	The KIT D816V mutation in formalin fixed paraffin embedded (FFPE) skin was evaluable in 87.5% of MCPM patients and had both 100% sensitivity and specificity.	Formaldehyde	26-34	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	4-7
35319189-6	2022	Significantly, with mPTP-F, we discovered that formaldehyde, a signaling molecule, could induce mPTP opening.	Formaldehyde	47-59	protein tyrosine phosphatase, receptor type, U	Mus musculus	20-26
35319189-6	2022	Significantly, with mPTP-F, we discovered that formaldehyde, a signaling molecule, could induce mPTP opening.	Formaldehyde	47-59	protein tyrosine phosphatase, receptor type, U	Mus musculus	96-100
35409327-5	2022	Formalin was injected in the hindpaw both for behavioral nociceptive evaluation and the immunodetection of Fos expression in the spinal cord.	Formaldehyde	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	107-110
35409327-6	2022	Hydrocephalic rats presented with a higher expression of TH at the LC, of TH and DBH at the spinal dorsal horn along with decreased nociceptive behavioral responses in the second (inflammatory) phase of the formalin test, and formalin-evoked Fos expression at the spinal dorsal horn.	Formaldehyde	226-234	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	242-245
35379891-5	2022	The network analyses led to the construction of the respiratory system-related biological network associated with formaldehyde exposure, and six upregulated hub genes (AREG, CXCL2, HMOX1, PLAUR, PTGS2, and TIMP1) were identified.	Formaldehyde	114-126	heme oxygenase 1	Homo sapiens	181-186
35379891-5	2022	The network analyses led to the construction of the respiratory system-related biological network associated with formaldehyde exposure, and six upregulated hub genes (AREG, CXCL2, HMOX1, PLAUR, PTGS2, and TIMP1) were identified.	Formaldehyde	114-126	plasminogen activator, urokinase receptor	Homo sapiens	188-193
35379891-5	2022	The network analyses led to the construction of the respiratory system-related biological network associated with formaldehyde exposure, and six upregulated hub genes (AREG, CXCL2, HMOX1, PLAUR, PTGS2, and TIMP1) were identified.	Formaldehyde	114-126	prostaglandin-endoperoxide synthase 2	Homo sapiens	195-200
35379891-5	2022	The network analyses led to the construction of the respiratory system-related biological network associated with formaldehyde exposure, and six upregulated hub genes (AREG, CXCL2, HMOX1, PLAUR, PTGS2, and TIMP1) were identified.	Formaldehyde	114-126	TIMP metallopeptidase inhibitor 1	Homo sapiens	206-211
35379891-7	2022	Furthermore, NRARP was newly found as a potential gene associated with the respiratory and carcinogenic effects of formaldehyde by comparison with human in vivo and in vitro formaldehyde-exposure data.	Formaldehyde	115-127	NOTCH regulated ankyrin repeat protein	Homo sapiens	13-18
35253509-0	2022	Vascular E-selectin Expression Detected in Formalin-fixed, Paraffin-embedded Sections With an E-selectin Monoclonal Antibody Correlates With Ulcerative Colitis Activity.	Formaldehyde	43-51	selectin E	Homo sapiens	9-19
35253509-2	2022	However, immunohistological analysis of E-selectin has been hampered by lack of E-selectin-specific monoclonal antibodies that can stain formalin-fixed, paraffin-embedded (FFPE) tissue sections.	Formaldehyde	137-145	selectin E	Homo sapiens	40-50
35253509-2	2022	However, immunohistological analysis of E-selectin has been hampered by lack of E-selectin-specific monoclonal antibodies that can stain formalin-fixed, paraffin-embedded (FFPE) tissue sections.	Formaldehyde	137-145	selectin E	Homo sapiens	80-90
35359901-5	2022	Methods: We performed RET rs2435357 genotyping from 73 HSCR formalin-fixed and paraffin-embedded (FFPE) rectal and 60 non-HSCR controls using the PCR-RFLP method.	Formaldehyde	60-68	ret proto-oncogene	Homo sapiens	22-25
35424850-1	2022	An anthracenecarboximide-guanidine based turn-on fluorescent probe ANC-DCP-1 for selective detection of glyoxals (methylglyoxal and glyoxal, GOS) over formaldehyde under weak acidic conditions around pH 6.0 was reported.	Formaldehyde	151-163	decapping mRNA 1B	Homo sapiens	71-76
35304863-7	2022	The duration of pain-related behaviors was prolonged in both phases I (0-5 min) and II (10-60 min) and the interphase; and the number of c-Fos-immunoreactive nuclei increased in laminae I-II, III-IV, and V-VI at the spinal segments L3-L5 on the side ipsilateral to the formalin injection, and these factors were significantly and positively correlated.	Formaldehyde	269-277	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	137-142
35335569-2	2022	Highly adsorptive composite (MCH-ATA) was produced by the reaction of chitosan with formaldehyde and amino thiazole derivative.	Formaldehyde	84-96	pro-melanin concentrating hormone	Homo sapiens	29-32
35217179-9	2022	Formalin-inactivated CyHV-2 vaccine showed a significant up-regulation of the genes CD8 and IFN-Upsilon by the 6th hr post-vaccination onwards.	Formaldehyde	0-8	CD8a molecule	Homo sapiens	84-87
34984861-4	2022	METHODS: Fluorescence in situ hybridization (FISH) was performed on formalin-fixed paraffin-embedded specimens (FFPE) to examine mouse double minute 2 homolog (MDM2) amplification in all cases.	Formaldehyde	68-76	transformed mouse 3T3 cell double minute 2	Mus musculus	160-164
35131666-5	2022	PATIENTS AND METHODS: We retrospectively assessed GATA-3 gene expression by quantitative real time PCR (qRT-PCR) from neoplastic biopsies in Formalin-Fixed Paraffin-Embedded samples (FFPE) of 80 patients with nPTCL that were admitted in a single cancer treatment center from 2000 to 2017.	Formaldehyde	141-149	GATA binding protein 3	Homo sapiens	50-56
35020071-5	2022	Formaldehyde-fixed, paraffin-embedded samples of 180 breast cancer patients were analyzed for BCL3 expression by immunohistochemistry.	Formaldehyde	0-12	BCL3 transcription coactivator	Homo sapiens	94-98
35014680-4	2022	TGM2 expression was shown to be elevated in formalin-fixed paraffin-embedded skin biopsies from patients with T-cell lymphoma relative to skin tissue from healthy cases.	Formaldehyde	44-52	transglutaminase 2	Homo sapiens	0-4
35134435-4	2022	Therefore, different tumor cells and THP-1 derived macrophages were utilized to explore the metabolism-related effects induced by formaldehyde at environmentally relevant concentrations.	Formaldehyde	130-142	GLI family zinc finger 2	Homo sapiens	37-42
35134435-5	2022	Significant increases of glucose uptake, glycolysis levels, HIF-1alpha signaling and methylglyoxal production were observed in tumor cells treated with 20 and 50 muM formaldehyde for 24 h, and the overproduced methylglyoxal in the conditioned medium collected from the tumor cells treated with formaldehyde triggered macrophage polarization towards M2 cells.	Formaldehyde	166-178	hypoxia inducible factor 1 subunit alpha	Homo sapiens	60-70
35087680-6	2022	For formalin-fixed samples, the mean rho B for tumors showed a statistically significant fold change of 4.42 (P = 0.014) when the tissue was heated from 25  C to 37  C compared to the adjacent normal tissue, which showed a fold change of 3.47.	Formaldehyde	4-12	ras homolog family member B	Homo sapiens	37-42
35048461-0	2022	Clinicopathological significance of CBX3 in colorectal cancer: An intensive expression study based on formalin-fixed and paraffin-embedded tissues.	Formaldehyde	102-110	chromobox 3	Rattus norvegicus	36-40
35048461-3	2022	In this study, we examined CBX3 protein expression in formalin-fixed and paraffin-embedded normal mucosae, hyperplastic polyps, low-and high-grade adenomas, and CRC tissue samples using immunohistochemistry.	Formaldehyde	54-62	chromobox 3	Rattus norvegicus	27-31
35207502-0	2022	Dexmedetomidine Co-Administered with Lidocaine Decreases Nociceptive Responses and Trigeminal Fos Expression without Motor Dysfunction and Hypotension in a Murine Orofacial Formalin Model.	Formaldehyde	173-181	FBJ osteosarcoma oncogene	Mus musculus	94-97
35208514-3	2022	Materials and Methods: The gene expression profiles of CD74 and HLA-DRA were determined in formalin-fixed paraffin-embedded tissues, with three samples each from normal cervixes, human papillomavirus type 16/18-positive, low-grade CIN (LGCIN), high-grade CIN (HGCIN), and squamous cell carcinoma (SCC) using Human Transcriptome Array 2.0.	Formaldehyde	91-99	CD74 molecule	Homo sapiens	55-59
35208514-3	2022	Materials and Methods: The gene expression profiles of CD74 and HLA-DRA were determined in formalin-fixed paraffin-embedded tissues, with three samples each from normal cervixes, human papillomavirus type 16/18-positive, low-grade CIN (LGCIN), high-grade CIN (HGCIN), and squamous cell carcinoma (SCC) using Human Transcriptome Array 2.0.	Formaldehyde	91-99	major histocompatibility complex, class II, DR alpha	Homo sapiens	64-71
35160409-1	2022	Combining the characteristics of rare earth extractants and water-soluble polymer complexants, a novel complexant phosphorylated chitosan (PCS) was synthesized by Kabachnik-Fields reaction with alkalized chitosan, dimethyl phosphonate, and formaldehyde as raw materials and toluene-4-sulfonic acid monohydrate (TsOH) as catalyst.	Formaldehyde	240-252	PCS	Homo sapiens	139-142
35231573-7	2022	Bioinformatics analysis shows that the pathogenesis of formaldehyde exposure-induced CHD may involve Hippo-YAP pathway Notch signaling pathway and other pathways.	Formaldehyde	55-67	Yes1 associated transcriptional regulator	Rattus norvegicus	107-110
35221998-3	2022	The relationship of urine formaldehyde with APOE genotype, brain Abeta status and plasma pathological markers in AD are also not clear.	Formaldehyde	26-38	apolipoprotein E	Homo sapiens	44-48
35221998-3	2022	The relationship of urine formaldehyde with APOE genotype, brain Abeta status and plasma pathological markers in AD are also not clear.	Formaldehyde	26-38	amyloid beta precursor protein	Homo sapiens	65-70
35221998-4	2022	This study intends to explore the correlation between urine formaldehyde and cognitive abilities throughout the AD continuum, to evaluate the role of APOE genotype and Abeta accumulation on urine formaldehyde, and further to clarify the relationship between urine formaldehyde level and AD plasma pathological markers.	Formaldehyde	196-208	amyloid beta precursor protein	Homo sapiens	168-173
35163506-6	2022	Five formalin-fixed paraffin-embedded (FFPE) metastatic PAC specimens were successfully assayed with OCP, and KRAS was the most prevalent alteration, which might contraindicate the use of anti-EGFR therapy.	Formaldehyde	5-13	KRAS proto-oncogene, GTPase	Homo sapiens	110-114
35038863-4	2022	In this study, CLC microcapsules containing cellulose nanocrystals (CNCs) and a melamine-formaldehyde (MF) resin hybrid shell were fabricated via in situ polymerization using CNC-stabilized Pickering emulsions as templates.	Formaldehyde	89-101	Charcot-Leyden crystal galectin	Homo sapiens	15-18
35425273-4	2022	It is found that a considerable blue-shift of Csp2 -H stretching frequency in the Csp2 -H O H-bond is mainly determined by an addition of water into the complexes along with the low polarity of the Csp2 -H covalent bond in formaldehyde and acetaldehyde.	Formaldehyde	223-235	regulator of calcineurin 2	Homo sapiens	46-50
35425273-4	2022	It is found that a considerable blue-shift of Csp2 -H stretching frequency in the Csp2 -H O H-bond is mainly determined by an addition of water into the complexes along with the low polarity of the Csp2 -H covalent bond in formaldehyde and acetaldehyde.	Formaldehyde	223-235	regulator of calcineurin 2	Homo sapiens	82-86
35425273-4	2022	It is found that a considerable blue-shift of Csp2 -H stretching frequency in the Csp2 -H O H-bond is mainly determined by an addition of water into the complexes along with the low polarity of the Csp2 -H covalent bond in formaldehyde and acetaldehyde.	Formaldehyde	223-235	regulator of calcineurin 2	Homo sapiens	198-202
35264507-5	2022	Further, we performed RNA in situ hybridization targeting HTLV-1 bZIP factor (HBZ-ISH) using the formalin-fixed paraffin-embedded (FFPE) tissue samples of the mesopharyngeal tumor, and a high expression of HBZ was found in the tumor cells, leading to the diagnosis of ATL.	Formaldehyde	97-105	hemoglobin subunit zeta	Homo sapiens	78-81
35118177-4	2022	Here we describe an adapted formaldehyde RNA immunoprecipitation (fRIP) protocol to identify the in vivo RNA targets of a cytoplasmic RNA-binding protein, YTHDC2, from testis, during the first wave of spermatogenesis, at the stage when germ cells are shutting off the proliferative program and initiating terminal differentiation ( Bailey et al., 2017 ).	Formaldehyde	28-40	YTH domain containing 2	Mus musculus	155-161
34232949-10	2022	Whole-exome sequencing analysis and RNA-seq results of formalin-fixed and paraffin-embedded tissue revealed nine mutant genes (AHNAK2, BFSP1, BRAF, CNTNAP3, DNHD1, MTOR, NFATC3, NOM1).	Formaldehyde	55-63	AHNAK nucleoprotein 2	Homo sapiens	127-133
34232949-10	2022	Whole-exome sequencing analysis and RNA-seq results of formalin-fixed and paraffin-embedded tissue revealed nine mutant genes (AHNAK2, BFSP1, BRAF, CNTNAP3, DNHD1, MTOR, NFATC3, NOM1).	Formaldehyde	55-63	beaded filament structural protein 1	Homo sapiens	135-140
34232949-10	2022	Whole-exome sequencing analysis and RNA-seq results of formalin-fixed and paraffin-embedded tissue revealed nine mutant genes (AHNAK2, BFSP1, BRAF, CNTNAP3, DNHD1, MTOR, NFATC3, NOM1).	Formaldehyde	55-63	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	142-146
34232949-10	2022	Whole-exome sequencing analysis and RNA-seq results of formalin-fixed and paraffin-embedded tissue revealed nine mutant genes (AHNAK2, BFSP1, BRAF, CNTNAP3, DNHD1, MTOR, NFATC3, NOM1).	Formaldehyde	55-63	contactin associated protein family member 3	Homo sapiens	148-155
34232949-10	2022	Whole-exome sequencing analysis and RNA-seq results of formalin-fixed and paraffin-embedded tissue revealed nine mutant genes (AHNAK2, BFSP1, BRAF, CNTNAP3, DNHD1, MTOR, NFATC3, NOM1).	Formaldehyde	55-63	dynein heavy chain domain 1	Homo sapiens	157-162
34232949-10	2022	Whole-exome sequencing analysis and RNA-seq results of formalin-fixed and paraffin-embedded tissue revealed nine mutant genes (AHNAK2, BFSP1, BRAF, CNTNAP3, DNHD1, MTOR, NFATC3, NOM1).	Formaldehyde	55-63	mechanistic target of rapamycin kinase	Homo sapiens	164-168
35096084-5	2022	The STC2 immunohistochemical expression was detected and evaluated in 60 cases of colorectal cancer tissue samples of formalin-fixed and paraffin-embedded blocks.	Formaldehyde	118-126	stanniocalcin 2	Homo sapiens	4-8