PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
26263376-0	2015	Lyso-Sulfatide Binds Factor Xa and Inhibits Thrombin Generation by the Prothrombinase Complex.	psychosine-3'-sulfate ester	0-14	coagulation factor X	Homo sapiens	21-30
2398033-7	1990	Furthermore, 13C-NMR signals of C-1 to C-5 of the sphingosine moiety showed significantly different chemical shifts between the lysosulfatide and galactopsychosine.	psychosine-3'-sulfate ester	128-141	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	32-42
34375644-0	2021	Deletion of fatty acid amide hydrolase reduces lyso-sulfatide levels but exacerbates metachromatic leukodystrophy in mice.	psychosine-3'-sulfate ester	47-61	fatty acid amide hydrolase	Mus musculus	12-38
34375644-8	2021	Consistent with the in vitro data, deletion of FAAH lowered lyso-sulfatide levels in a mouse model of MLD.	psychosine-3'-sulfate ester	60-74	fatty acid amide hydrolase	Mus musculus	47-51
16450077-4	2006	In the present study we show that interaction of the HDL-associated sphingosylphosphorylcholine and sphingosylgalactosyl-3-sulfate (lysosulfatide, LSF) with the G-protein-coupled EDG receptor initiates a signalling cascade that activates the protein kinase Akt and reduces the E-selectin, ICAM-1 and VCAM-1 expression on protein and mRNA level.	psychosine-3'-sulfate ester	132-145	AKT serine/threonine kinase 1	Homo sapiens	257-260
16450077-4	2006	In the present study we show that interaction of the HDL-associated sphingosylphosphorylcholine and sphingosylgalactosyl-3-sulfate (lysosulfatide, LSF) with the G-protein-coupled EDG receptor initiates a signalling cascade that activates the protein kinase Akt and reduces the E-selectin, ICAM-1 and VCAM-1 expression on protein and mRNA level.	psychosine-3'-sulfate ester	132-145	selectin E	Homo sapiens	277-287
16450077-4	2006	In the present study we show that interaction of the HDL-associated sphingosylphosphorylcholine and sphingosylgalactosyl-3-sulfate (lysosulfatide, LSF) with the G-protein-coupled EDG receptor initiates a signalling cascade that activates the protein kinase Akt and reduces the E-selectin, ICAM-1 and VCAM-1 expression on protein and mRNA level.	psychosine-3'-sulfate ester	132-145	intercellular adhesion molecule 1	Homo sapiens	289-295
16450077-4	2006	In the present study we show that interaction of the HDL-associated sphingosylphosphorylcholine and sphingosylgalactosyl-3-sulfate (lysosulfatide, LSF) with the G-protein-coupled EDG receptor initiates a signalling cascade that activates the protein kinase Akt and reduces the E-selectin, ICAM-1 and VCAM-1 expression on protein and mRNA level.	psychosine-3'-sulfate ester	132-145	vascular cell adhesion molecule 1	Homo sapiens	300-306
14511654-3	2003	We here investigated the effects of sphingosylphosphorylcholine (SPC) and lysosulfatide (LSF), two lysosphingolipids associated with HDL, on TNF-alpha-induced E-selectin expression in human umbilical endothelial cells.	psychosine-3'-sulfate ester	74-87	tumor necrosis factor	Homo sapiens	141-150
14511654-3	2003	We here investigated the effects of sphingosylphosphorylcholine (SPC) and lysosulfatide (LSF), two lysosphingolipids associated with HDL, on TNF-alpha-induced E-selectin expression in human umbilical endothelial cells.	psychosine-3'-sulfate ester	74-87	selectin E	Homo sapiens	159-169
14511654-3	2003	We here investigated the effects of sphingosylphosphorylcholine (SPC) and lysosulfatide (LSF), two lysosphingolipids associated with HDL, on TNF-alpha-induced E-selectin expression in human umbilical endothelial cells.	psychosine-3'-sulfate ester	89-92	tumor necrosis factor	Homo sapiens	141-150
14511654-3	2003	We here investigated the effects of sphingosylphosphorylcholine (SPC) and lysosulfatide (LSF), two lysosphingolipids associated with HDL, on TNF-alpha-induced E-selectin expression in human umbilical endothelial cells.	psychosine-3'-sulfate ester	89-92	selectin E	Homo sapiens	159-169
11432865-7	2001	Two bioactive lysosphingolipids present in HDL particles, sphingosylphosphorylcholine and lysosulfatide, fully mimicked the survival effect of HDL by blocking the mitochondrial pathway of apoptosis and potently activating Akt.	psychosine-3'-sulfate ester	90-103	AKT serine/threonine kinase 1	Homo sapiens	222-225
11106499-11	2000	Analysis of this fraction with high-performance liquid chromatography (HPLC) and time-of-flight secondary ion mass spectroscopy (TOF-SIMS) revealed that the PI-PLC-inducing activity is identical with two bioactive lysosphingolipids, namely, lysosulfatide (LSF) and sphingosylphosphorylcholine (SPC).	psychosine-3'-sulfate ester	241-254	phospholipase C beta 1	Homo sapiens	157-163
11106499-11	2000	Analysis of this fraction with high-performance liquid chromatography (HPLC) and time-of-flight secondary ion mass spectroscopy (TOF-SIMS) revealed that the PI-PLC-inducing activity is identical with two bioactive lysosphingolipids, namely, lysosulfatide (LSF) and sphingosylphosphorylcholine (SPC).	psychosine-3'-sulfate ester	256-259	phospholipase C beta 1	Homo sapiens	157-163
26263376-0	2015	Lyso-Sulfatide Binds Factor Xa and Inhibits Thrombin Generation by the Prothrombinase Complex.	psychosine-3'-sulfate ester	0-14	coagulation factor II, thrombin	Homo sapiens	44-52
26263376-0	2015	Lyso-Sulfatide Binds Factor Xa and Inhibits Thrombin Generation by the Prothrombinase Complex.	psychosine-3'-sulfate ester	0-14	coagulation factor X	Homo sapiens	71-85
26263376-2	2015	Lysosulfatide (lyso-SF) (sulfogalactosyl sphingosine) prolonged factor Xa (fXa) 1-stage plasma clotting assays, showing it had robust anticoagulant activity.	psychosine-3'-sulfate ester	0-13	coagulation factor X	Homo sapiens	64-73
26263376-2	2015	Lysosulfatide (lyso-SF) (sulfogalactosyl sphingosine) prolonged factor Xa (fXa) 1-stage plasma clotting assays, showing it had robust anticoagulant activity.	psychosine-3'-sulfate ester	0-13	coagulation factor X	Homo sapiens	75-78
26263376-2	2015	Lysosulfatide (lyso-SF) (sulfogalactosyl sphingosine) prolonged factor Xa (fXa) 1-stage plasma clotting assays, showing it had robust anticoagulant activity.	psychosine-3'-sulfate ester	15-22	coagulation factor X	Homo sapiens	64-73
26263376-2	2015	Lysosulfatide (lyso-SF) (sulfogalactosyl sphingosine) prolonged factor Xa (fXa) 1-stage plasma clotting assays, showing it had robust anticoagulant activity.	psychosine-3'-sulfate ester	15-22	coagulation factor X	Homo sapiens	75-78
26263376-8	2015	Thus, lyso-SF is an anticoagulant lipid that inhibits fXa when this enzyme is bound to either phospholipids or to fVa.	psychosine-3'-sulfate ester	6-13	coagulation factor X	Homo sapiens	54-57
26263376-10	2015	This suggests that certain sphingolipids, including lyso-SF and some of its analogs, may down-regulate fXa activity without inhibiting the enzyme"s active site or binding to the fXa Gla domain.	psychosine-3'-sulfate ester	52-59	coagulation factor X	Homo sapiens	103-106
18719997-4	2009	These cells express the lysosulfatide receptor S1P3 according to RT-PCR, western blotting and immunocytochemistry, but S1P3 does not mediate the effect since preincubation with three different compounds known to inhibit S1P3 did not block lysosulfatide-induced cell rounding.	psychosine-3'-sulfate ester	24-37	sphingosine-1-phosphate receptor 3	Homo sapiens	47-51
22820602-2	2012	Here we describe the structure of a type II NKT cell TCR in complex with CD1d-lysosulfatide.	psychosine-3'-sulfate ester	78-91	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	53-56
22820602-2	2012	Here we describe the structure of a type II NKT cell TCR in complex with CD1d-lysosulfatide.	psychosine-3'-sulfate ester	78-91	CD1d molecule	Homo sapiens	73-77
21081108-3	2011	Here, we report that two lysosphingolipids, sphingosylphosphorylcholine (SPC) and lysosulfatide (LSF), inversely affect macrophagic differentiation of monocytic cell lines, U937 and THP-1.	psychosine-3'-sulfate ester	82-95	GLI family zinc finger 2	Homo sapiens	182-187
21081108-3	2011	Here, we report that two lysosphingolipids, sphingosylphosphorylcholine (SPC) and lysosulfatide (LSF), inversely affect macrophagic differentiation of monocytic cell lines, U937 and THP-1.	psychosine-3'-sulfate ester	97-100	GLI family zinc finger 2	Homo sapiens	182-187
26000324-1	2015	OBJECTIVE: Metachromatic leukodystrophy (MLD) is an autosomal recessive lysosomal storage disorder due to deficient activity of arylsulfatase A (ASA) that causes accumulation of sulfatide and lysosulfatide.	psychosine-3'-sulfate ester	192-205	arylsulfatase A	Homo sapiens	128-143
18292516-4	2008	In comparison to other sulfatides or alphaGalCer, lyso-sulfatide binds with lower affinity to CD1d.	psychosine-3'-sulfate ester	50-64	CD1d molecule	Homo sapiens	94-98
18292516-5	2008	Although plate-bound CD1d is inefficient in presenting lyso-sulfatide at neutral pH, it is efficiently presented at acidic pH and in the presence of saposin C. The lysosomal trafficking of mCD1d is required for alphaGalCer presentation to type I NKT cells, it is not important for presentation of lyso-sulfatide to type II NKT cells.	psychosine-3'-sulfate ester	55-69	CD1d molecule	Homo sapiens	21-25
18292516-5	2008	Although plate-bound CD1d is inefficient in presenting lyso-sulfatide at neutral pH, it is efficiently presented at acidic pH and in the presence of saposin C. The lysosomal trafficking of mCD1d is required for alphaGalCer presentation to type I NKT cells, it is not important for presentation of lyso-sulfatide to type II NKT cells.	psychosine-3'-sulfate ester	297-311	CD1d molecule	Homo sapiens	21-25
18292516-5	2008	Although plate-bound CD1d is inefficient in presenting lyso-sulfatide at neutral pH, it is efficiently presented at acidic pH and in the presence of saposin C. The lysosomal trafficking of mCD1d is required for alphaGalCer presentation to type I NKT cells, it is not important for presentation of lyso-sulfatide to type II NKT cells.	psychosine-3'-sulfate ester	297-311	CD1 antigen complex	Mus musculus	189-193
18292516-9	2008	Our data collectively suggest that weak CD1d-binding self-glycolipid ligands such as lyso-sulfatide can be presented via the secretory and endosomal compartments.	psychosine-3'-sulfate ester	85-99	CD1d molecule	Homo sapiens	40-44