PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
31992110-8	2021	When activated with ADP or TRAP protamine at 80 microg/mL reduced aggregation, from 73.8 +- 29.4 U to 46.9 +- 21.1 U (p < .001) with ADP and from 126.4 +- 16.1 U to 94.9 +- 23.7 U (p < .01) with TRAP.	Insulin, Isophane	32-41	TRAP	Homo sapiens	27-31
6850362-6	1983	Among these insulin treated groups, the PZI-treated group showed the greatest number of degenerating profiles while the minipump group showed the least.	Insulin, Isophane	40-43	insulin	Homo sapiens	12-19
740740-4	1978	Daily administration of 2 U protamine zinc insulin (PZI)/100 g body weight to diabetic rats returned these measurements to normal levels.	Insulin, Isophane	52-55	insulin	Bos taurus	43-50
301774-2	1977	We have now investigated solid human breast cancer biopsies and find that proteolytic activities in extracts from the nuclear pellets of these biopsies interfere with or prevent the measurement of nuclear estrogen receptor when the protamine assay is used.	Insulin, Isophane	232-241	estrogen receptor 1	Homo sapiens	205-222
33785775-9	2021	By contrast, the cell death induced by pz III-PDT was inhibited by z-VAD-fmk and by the necroptosis inhibitor, necrostatin-1 s. Cancer cells induced by pz I-PDT or pz III-PDT released HMGB1 and ATP and were engulfed by bone marrow-derived dendritic cells, which then matured and became activated in vitro.	Insulin, Isophane	39-43	high mobility group box 1	Mus musculus	184-189
31992110-0	2021	Protamine stimulates platelet aggregation in vitro with activation of the fibrinogen receptor and alpha-granule release, but impairs secondary activation via ADP and thrombin receptors.	Insulin, Isophane	0-9	coagulation factor II, thrombin	Homo sapiens	166-174
31992110-8	2021	When activated with ADP or TRAP protamine at 80 microg/mL reduced aggregation, from 73.8 +- 29.4 U to 46.9 +- 21.1 U (p < .001) with ADP and from 126.4 +- 16.1 U to 94.9 +- 23.7 U (p < .01) with TRAP.	Insulin, Isophane	32-41	TRAP	Homo sapiens	201-205
31992110-6	2021	We found that in the absence of other activators, protamine (80 microg/mL) increased the proportion of platelets with active fibrinogen receptor (binding of PAC-1) from 3.6% to 97.0% (p < .001) measured with flow cytometry.	Insulin, Isophane	50-59	ADCYAP receptor type I	Homo sapiens	157-162
31992110-9	2021	P-selectin exposure (a marker of alpha-granule release) measured by median fluorescence intensity (MFI) increased dose dependently with protamine alone, from 0.76 +- 0.20 (0 microg/mL) to 10.2 +- 3.1 (80 microg/mL), p < .001.	Insulin, Isophane	136-145	selectin P	Homo sapiens	0-10
31992110-11	2021	When protamine was combined with ADP or TRAP, there was a concentration-dependent increase in the alpha-granule release.	Insulin, Isophane	5-14	TRAP	Homo sapiens	40-44
31593829-3	2019	Based on the idea that the optimization of the components is required to improve transfection efficiency, the present study aimed to formulate and characterize cholesteryl oleate-containing solid-lipid nanoparticles (CO-SLNs) incorporating protamine (P) to condense DNA to produce P:DNA:CO-SLN complexes as non-viral vectors for gene delivery with reduced cytotoxicity and high cellular uptake efficiency.	Insulin, Isophane	240-249	sarcolipin	Homo sapiens	220-223
31932482-6	2020	Coincident with round spermatid arrest, we find reduced mRNA expression of transition protein (Tnp1 and Tnp2) and protamine (Prm1 and Prm2) genes, which are critical for the specialized maturation of haploid male germ cells called spermiogenesis.	Insulin, Isophane	114-123	protamine 1	Mus musculus	125-129
31932482-6	2020	Coincident with round spermatid arrest, we find reduced mRNA expression of transition protein (Tnp1 and Tnp2) and protamine (Prm1 and Prm2) genes, which are critical for the specialized maturation of haploid male germ cells called spermiogenesis.	Insulin, Isophane	114-123	protamine 2	Mus musculus	134-138
31593829-8	2019	Transfection studies in human embryonic kidney (HEK293T) cells showed the versatility of adding protamine to efficiently transfect cells, widening the potential applications of CO-SLN-based vectors, since the incorporation of protamine induced almost a 200-fold increase in the transfection capacity of CO-SLNs without toxicity.	Insulin, Isophane	96-105	sarcolipin	Homo sapiens	180-183
31768180-7	2019	Results: Availability in public pharmacies is 63.2% for regular insulin and 68.4% for NPH (isophane) insulin, but differences in availability were observed between levels of care and between regions.	Insulin, Isophane	91-99	insulin	Homo sapiens	101-108
27212152-9	2016	Furthermore, PZI combined with Se upregulated phosphatidylinositol 3-kinase (PI3K) and downregulated protein tyrosine phosphatase 1B (PTP1B).	Insulin, Isophane	13-16	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	46-75
28230445-12	2017	In general, for both existing and new basal insulin users, higher persistence rate and duration were associated with Medicare versus cash-pay patients, use of insulin pens versus vial/syringe, and use of insulin glargine versus NPH.	Insulin, Isophane	228-231	insulin	Homo sapiens	44-51
27212152-9	2016	Furthermore, PZI combined with Se upregulated phosphatidylinositol 3-kinase (PI3K) and downregulated protein tyrosine phosphatase 1B (PTP1B).	Insulin, Isophane	13-16	protein tyrosine phosphatase, non-receptor type 1	Mus musculus	101-132
27212152-9	2016	Furthermore, PZI combined with Se upregulated phosphatidylinositol 3-kinase (PI3K) and downregulated protein tyrosine phosphatase 1B (PTP1B).	Insulin, Isophane	13-16	protein tyrosine phosphatase, non-receptor type 1	Mus musculus	134-139
24843464-2	2011	MATERIALS AND METHODS:   We carried out a retrospective study to compare the effects of replacing NPH with detemir in basal-bolus insulin therapy in Japanese patients with type 1 diabetes.	Insulin, Isophane	98-101	insulin	Homo sapiens	130-137
24812692-9	2014	RESULTS: Treatment with NPH improved insulin secretion from beta-cells during the IPGTT and increased pancreatic islet size.	Insulin, Isophane	24-27	insulin	Homo sapiens	37-44
19279382-10	2009	Acute NPH injection had no impact on GK gene profiles in estradiol benzoate (EB)- or oil-implanted ovariectomized (OVX) female rats, but diminished GK-ir cell counts in the OVX + EB caudal ARH.	Insulin, Isophane	6-9	glucokinase	Rattus norvegicus	148-150
20678116-1	2010	AIMS: The aim of study was to evaluate the safety and efficacy of insulin detemir as a basal insulin switching from neutral protamine Hagedorn insulin (NPH) and insulin glargine in patients with diabetes on an intensive insulin therapy regimen.	Insulin, Isophane	152-155	insulin	Homo sapiens	66-73
20678116-5	2010	However, significant improvement was seen only among the patients who had previously used NPH as a basal insulin.	Insulin, Isophane	90-93	insulin	Homo sapiens	105-112
19418044-8	2009	Intracerebroventricular CP-472555 delivery in conjunction with antecedent NPH dosing prevented transcriptional habituation of GCK and OT genes, but did not modify CRH or VP mRNA profiles.	Insulin, Isophane	74-77	glucokinase	Rattus norvegicus	126-129
20298458-5	2010	Mean NPY and AgRP mRNA in harvested NPY neurones was unchanged or augmented, respectively, by one NPH dose, although repeated NPH administration up-regulated NPY, whereas AgRP gene transcripts were down-regulated.	Insulin, Isophane	98-101	neuropeptide Y	Homo sapiens	5-8
20298458-5	2010	Mean NPY and AgRP mRNA in harvested NPY neurones was unchanged or augmented, respectively, by one NPH dose, although repeated NPH administration up-regulated NPY, whereas AgRP gene transcripts were down-regulated.	Insulin, Isophane	98-101	agouti related neuropeptide	Homo sapiens	13-17
20298458-6	2010	NPH elicited divergent modifications in the ERalpha and ERbeta mRNA content of sampled neurones.	Insulin, Isophane	0-3	estrogen receptor 1	Homo sapiens	44-51
20298458-6	2010	NPH elicited divergent modifications in the ERalpha and ERbeta mRNA content of sampled neurones.	Insulin, Isophane	0-3	estrogen receptor 2	Homo sapiens	56-62
19279382-11	2009	Precedent NPH treatment did not modify baseline GK mRNA levels in either group of females, but resulted in decreased or elevated GK gene and protein expression during recurring injection in the presence or absence of EB, respectively.	Insulin, Isophane	10-13	glucokinase	Rattus norvegicus	129-131
19279382-12	2009	CONCLUSION: These results provide novel evidence for sex-specific patterns of acclimation of GK mRNA and protein expression within the rat ARH to serial NPH injection, and support the need to elucidate the physiological ramifications of these adaptations regarding behavioral and physiological responses to recurring intermediate insulin administration.	Insulin, Isophane	153-156	glucokinase	Rattus norvegicus	93-95
10638500-8	1999	CONCLUSION: In streptozotocin-diabetic rats, normal weight gain can be achieved by treatment with PZI insulin once daily, but attainment of near-normal glucose values requires administration of PZI, NPH, or 70/ 30 insulin twice daily.	Insulin, Isophane	98-101	insulin	Homo sapiens	102-109
17565917-5	2007	Treatment with insulin detemir+/-OHA was associated with increases in quality-adjusted life expectancy of 0.309, 0.350, and 0.333 quality-adjusted life-years (QALYs) versus treatment with OHA alone, NPH+/-OHA, and insulin glargine+/-OHA, respectively.	Insulin, Isophane	199-202	insulin	Homo sapiens	15-22
15498377-5	2004	A group of diabetic rats was then injected with protamine zinc insulin [PZI, 1 - 2 U x kg(-1) x d(-1)] for one week.	Insulin, Isophane	72-75	insulin	Homo sapiens	63-70