PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
18627029-3	2008	Here, we clone TAAR6 from the rhesus monkey and use transfected cells to investigate whether this receptor interacts with brain monoamines and a psychostimulant drug to trigger cAMP signaling or extracellular signal-regulated kinase (ERK) phosphorylation, while investigating its expression profile in the rhesus monkey brain.	monoamines	128-138	trace amine associated receptor 6	Macaca mulatta	15-20
18577569-10	2008	Together, these data suggest that VMAT2 regulates in vivo glucose homeostasis and insulin production, most likely via its role in vesicular transport and storage of monoamines in beta-cells.	monoamines	165-175	solute carrier family 18 member A2	Rattus norvegicus	34-39
21369437-9	2008	Moreover, petroleum ether extract also reduced the mouse whole brain monoamine oxidase (MAO-A and MAO-B) activities as compared to control, resulting in increase in the levels of brain monoamines.	monoamines	185-195	monoamine oxidase A	Mus musculus	88-93
18594799-2	2008	Projection pyramidal neurons and local GABAergic interneurons in mPFC express 5-HT(1A) receptors, whose activation modulates dopaminergic (DA) and serotonergic (5-HT) activity in midbrain and the cortical release of both monoamines.	monoamines	221-231	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	78-85
18437281-1	2008	Monoamine oxidase A (MAOA) abnormality has been suggested as a crucial factor in the pathogenesis of mood disorder, because MAOA is associated with the metabolism of monoamines such as serotonin and norepinephrine.	monoamines	166-176	monoamine oxidase A	Homo sapiens	0-19
18437281-1	2008	Monoamine oxidase A (MAOA) abnormality has been suggested as a crucial factor in the pathogenesis of mood disorder, because MAOA is associated with the metabolism of monoamines such as serotonin and norepinephrine.	monoamines	166-176	monoamine oxidase A	Homo sapiens	21-25
18437281-1	2008	Monoamine oxidase A (MAOA) abnormality has been suggested as a crucial factor in the pathogenesis of mood disorder, because MAOA is associated with the metabolism of monoamines such as serotonin and norepinephrine.	monoamines	166-176	monoamine oxidase A	Homo sapiens	124-128
18041582-1	2008	The vesicular monoamine transporter 2 (VMAT2) sequesters monoamines into synaptic vesicles in preparation for neurotransmission.	monoamines	57-67	solute carrier family 18 (vesicular monoamine), member 2	Mus musculus	4-37
18480678-2	2008	threo-methylphenidate inhibits the dopamine transporter and the norepinephrine transporter, resulting in elevations of these monoamines after impulse release.	monoamines	125-135	solute carrier family 6 member 3	Homo sapiens	35-55
18480678-2	2008	threo-methylphenidate inhibits the dopamine transporter and the norepinephrine transporter, resulting in elevations of these monoamines after impulse release.	monoamines	125-135	solute carrier family 6 member 2	Homo sapiens	64-90
18041582-1	2008	The vesicular monoamine transporter 2 (VMAT2) sequesters monoamines into synaptic vesicles in preparation for neurotransmission.	monoamines	57-67	solute carrier family 18 (vesicular monoamine), member 2	Mus musculus	39-44
17898223-1	2007	The vesicular monoamine transporter 2 (VMAT2) is localized primarily within the CNS and is responsible for transporting monoamines from the cytoplasm into secretory vesicles.	monoamines	120-130	solute carrier family 18 (vesicular monoamine), member 2	Mus musculus	4-37
17766642-1	2007	Monoamines, such as serotonin, dopamine, and norepinephrine, are sequestered into synaptic vesicles by specific transporters (vesicular monoamine transporter-2; VMAT2) using energy from an electrochemical proton gradient across the vesicle membranes.	monoamines	0-10	solute carrier family 18 member A2	Homo sapiens	126-159
17766642-1	2007	Monoamines, such as serotonin, dopamine, and norepinephrine, are sequestered into synaptic vesicles by specific transporters (vesicular monoamine transporter-2; VMAT2) using energy from an electrochemical proton gradient across the vesicle membranes.	monoamines	0-10	solute carrier family 18 member A2	Homo sapiens	161-166
17393420-1	2007	The non-neuronal monoamine transporters (OCT1, OCT2, EMT, and PMAT) play a key role in the clearance of monoamines from extracellular compartments.	monoamines	104-114	solute carrier family 22 member 1	Homo sapiens	41-45
17393420-1	2007	The non-neuronal monoamine transporters (OCT1, OCT2, EMT, and PMAT) play a key role in the clearance of monoamines from extracellular compartments.	monoamines	104-114	solute carrier family 22 member 2	Homo sapiens	47-51
17393420-1	2007	The non-neuronal monoamine transporters (OCT1, OCT2, EMT, and PMAT) play a key role in the clearance of monoamines from extracellular compartments.	monoamines	104-114	solute carrier family 22 member 3	Homo sapiens	53-56
17393420-1	2007	The non-neuronal monoamine transporters (OCT1, OCT2, EMT, and PMAT) play a key role in the clearance of monoamines from extracellular compartments.	monoamines	104-114	solute carrier family 29 member 4	Homo sapiens	62-66
17393420-7	2007	Our present results demonstrate that PMAT, EMT, and OCT2 transporters are expressed in the endometrial stroma and can potentially regulate reuptake of monoamines in general and histamine in particular.	monoamines	151-161	solute carrier family 29 member 4	Homo sapiens	37-41
17393420-7	2007	Our present results demonstrate that PMAT, EMT, and OCT2 transporters are expressed in the endometrial stroma and can potentially regulate reuptake of monoamines in general and histamine in particular.	monoamines	151-161	solute carrier family 22 member 3	Homo sapiens	43-46
17393420-7	2007	Our present results demonstrate that PMAT, EMT, and OCT2 transporters are expressed in the endometrial stroma and can potentially regulate reuptake of monoamines in general and histamine in particular.	monoamines	151-161	solute carrier family 22 member 2	Homo sapiens	52-56
17908235-8	2007	Upon transfection of the cells with siRNAs targeted at SULT1A3, diminishment of the SULT1A3 protein and concomitantly the sulfating activity toward these hydroxylated monoamines was observed.	monoamines	167-177	sulfotransferase family 1A member 3	Homo sapiens	55-62
17908235-8	2007	Upon transfection of the cells with siRNAs targeted at SULT1A3, diminishment of the SULT1A3 protein and concomitantly the sulfating activity toward these hydroxylated monoamines was observed.	monoamines	167-177	sulfotransferase family 1A member 3	Homo sapiens	84-91
17908235-10	2007	By serving as substrates for SULT1A3, these hydroxylated monoamines may interfere with the homeostasis of endogenous serotonin and dopamine.	monoamines	57-67	sulfotransferase family 1A member 3	Homo sapiens	29-36
17314919-8	2007	Finally, brain monoamines seem to be critical mediators of antidepressant-induced TrkB activation, as antidepressants reboxetine and citalopram do not produce TrkB activation in the brains of serotonin- or norepinephrine-depleted mice.	monoamines	15-25	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	82-86
17898223-1	2007	The vesicular monoamine transporter 2 (VMAT2) is localized primarily within the CNS and is responsible for transporting monoamines from the cytoplasm into secretory vesicles.	monoamines	120-130	solute carrier family 18 (vesicular monoamine), member 2	Mus musculus	39-44
17234900-1	2007	Trace amine-associated receptor 1 (TAAR1) is a G protein-coupled receptor that directly responds to endogenous monoamines as well as amphetamine-related psychostimulants, including methamphetamine.	monoamines	111-121	trace amine associated receptor 1	Macaca mulatta	35-40
17597580-1	2007	Monoamine oxidase B (MAO-B) functions in the deamination of monoamines, including dopamine and norepinephrine.	monoamines	60-70	monoamine oxidase B	Homo sapiens	0-19
17597580-1	2007	Monoamine oxidase B (MAO-B) functions in the deamination of monoamines, including dopamine and norepinephrine.	monoamines	60-70	monoamine oxidase B	Homo sapiens	21-26
17344033-1	2007	The vesicular monoamine transporter (VMAT2) plays a major role in the synaptic accumulation and quantal release of monoamines.	monoamines	115-125	solute carrier family 18 member A2	Homo sapiens	37-42
17433807-1	2007	The vesicular monoamine transporter type 2 (VMAT2) packages pre-synaptic monoamines into vesicles.	monoamines	73-83	solute carrier family 18 (vesicular monoamine), member 2	Mus musculus	4-42
17433807-1	2007	The vesicular monoamine transporter type 2 (VMAT2) packages pre-synaptic monoamines into vesicles.	monoamines	73-83	solute carrier family 18 (vesicular monoamine), member 2	Mus musculus	44-49
17350612-0	2007	Functional activation by central monoamines of human dopamine D(4) receptor polymorphic variants coupled to GIRK channels in Xenopus oocytes.	monoamines	33-43	dopamine receptor D4	Homo sapiens	53-75
17234899-1	2007	Trace amine-associated receptor 1 (TAAR1) is a G protein-coupled receptor activated by a broad range of monoamines and amphetamine-related psychostimulants.	monoamines	104-114	trace amine associated receptor 1	Macaca mulatta	0-33
17234899-1	2007	Trace amine-associated receptor 1 (TAAR1) is a G protein-coupled receptor activated by a broad range of monoamines and amphetamine-related psychostimulants.	monoamines	104-114	trace amine associated receptor 1	Macaca mulatta	35-40
17234900-1	2007	Trace amine-associated receptor 1 (TAAR1) is a G protein-coupled receptor that directly responds to endogenous monoamines as well as amphetamine-related psychostimulants, including methamphetamine.	monoamines	111-121	trace amine associated receptor 1	Macaca mulatta	0-33
17234900-4	2007	TAAR1 activation by monoamines and amphetamine-related compounds was greatly enhanced by coexpression of dopamine, norepinephrine, or serotonin transporters, and the activation enhancement was blocked by monoamine transporter inhibitors.	monoamines	20-30	trace amine associated receptor 1	Macaca mulatta	0-5
16983645-10	2006	Moreover, MAOB is region-dependently involved in responses of the brain to Amph and baclofen, supporting interactions between GABA and monoamines.	monoamines	135-145	monoamine oxidase B	Mus musculus	10-14
16220332-6	2007	MDMA exhibited the highest affinity for the NET>>SERT>or=DAT, the same rank order for MDMA inhibition of [(3)H]DA, [(3)H]NE, and [(3)H]5-HT transport and stimulated release of the [(3)H]monoamines, which differed from reports derived from rodent monoamine transporters.	monoamines	195-205	solute carrier family 6 member 4	Homo sapiens	55-59
16220332-6	2007	MDMA exhibited the highest affinity for the NET>>SERT>or=DAT, the same rank order for MDMA inhibition of [(3)H]DA, [(3)H]NE, and [(3)H]5-HT transport and stimulated release of the [(3)H]monoamines, which differed from reports derived from rodent monoamine transporters.	monoamines	195-205	solute carrier family 6 member 3	Homo sapiens	66-69
17156375-9	2006	Together with our previous studies on dopamine and serotonin transporters, we propose that a primary physiological role of alpha-Syn may be to regulate the homeostasis of monoamines in synapses, through modulatory interactions of the protein with monoaminergic transporters.	monoamines	171-181	synuclein alpha	Homo sapiens	123-132
17100850-3	2006	The vesicular monoamine transporter 2 (VMAT2) sequesters monoamines into synaptic vesicles, a process that, in addition to being important in normal transmission, may also act to keep intracellular levels of monoamine neurotransmitters below potentially toxic thresholds.	monoamines	57-67	solute carrier family 18 (vesicular monoamine), member 2	Mus musculus	4-37
17088501-2	2006	Monoamine oxidase A (MAO-A) is an enzyme that metabolizes monoamines, such as serotonin, norepinephrine, and dopamine.	monoamines	58-68	monoamine oxidase A	Homo sapiens	0-19
17088501-2	2006	Monoamine oxidase A (MAO-A) is an enzyme that metabolizes monoamines, such as serotonin, norepinephrine, and dopamine.	monoamines	58-68	monoamine oxidase A	Homo sapiens	21-26
17100850-3	2006	The vesicular monoamine transporter 2 (VMAT2) sequesters monoamines into synaptic vesicles, a process that, in addition to being important in normal transmission, may also act to keep intracellular levels of monoamine neurotransmitters below potentially toxic thresholds.	monoamines	57-67	solute carrier family 18 (vesicular monoamine), member 2	Mus musculus	39-44
17010132-1	2006	BACKGROUND: It is widely accepted that, in addition to removing acetaldehyde produced during the metabolism of ethanol, mitochondrial aldehyde dehydrogenase (ALDH2) functions in the pathway by which aldehyde metabolites of the monoamines dopamine (DA) and serotonin (5-HT) are converted to their acidic metabolites.	monoamines	227-237	aldehyde dehydrogenase 2, mitochondrial	Mus musculus	158-163
16862563-1	2006	Substance P receptor antagonists cause antidepressant- and anxiolytic-like effects in rodents that are thought to involve brain monoamines.	monoamines	128-138	tachykinin receptor 1	Rattus norvegicus	0-20
16189511-8	2006	DVMAT transgenes may be targeted to additional neuronal pathways using standard Drosophila techniques, and our results provide a novel paradigm to study the mechanisms by which monoamines regulate complex behaviors relevant to neuropsychiatric illness.	monoamines	177-187	Vesicular monoamine transporter	Drosophila melanogaster	0-5
16210420-2	2006	Because hypothalamic monoamines are intricately involved in the regulation of these functions, we hypothesized that leptin may produce its effects by altering the activity of these neurotransmitters.	monoamines	21-31	leptin	Rattus norvegicus	116-122
16210420-14	2006	These results indicate that both central and systemic administration of leptin can affect hypothalamic monoamines in a region-specific manner, which, in turn, could mediate many of leptin"s central and neuroendocrine effects.	monoamines	103-113	leptin	Rattus norvegicus	72-78
16210420-14	2006	These results indicate that both central and systemic administration of leptin can affect hypothalamic monoamines in a region-specific manner, which, in turn, could mediate many of leptin"s central and neuroendocrine effects.	monoamines	103-113	leptin	Rattus norvegicus	181-187
16116033-1	2006	Uptake of monoamines into secretory granules is mediated by the vesicular monoamine transporters VMAT1 and VMAT2.	monoamines	10-20	solute carrier family 18 member A1	Homo sapiens	97-102
16116033-1	2006	Uptake of monoamines into secretory granules is mediated by the vesicular monoamine transporters VMAT1 and VMAT2.	monoamines	10-20	solute carrier family 18 member A2	Homo sapiens	107-112
16828062-6	2006	The initial increase in the BDNF levels return to basal levels when incubation with monoamines is extended beyond 12 h (for 5-HT) or 24 h (for NA and DA).	monoamines	84-94	brain-derived neurotrophic factor	Rattus norvegicus	28-32
16581093-5	2006	After normalization with MPP+ uptake, OCT2 and OCT3 subtypes share a similar monoamine preference profile, with higher transport efficacies for epinephrine and histamine than for the other monoamines.	monoamines	189-199	solute carrier family 22 member 2	Rattus norvegicus	38-42
16581093-5	2006	After normalization with MPP+ uptake, OCT2 and OCT3 subtypes share a similar monoamine preference profile, with higher transport efficacies for epinephrine and histamine than for the other monoamines.	monoamines	189-199	solute carrier family 22 member 8	Rattus norvegicus	47-51
16505837-1	2006	The enzyme catechol-O-methyl transferase (COMT), identified in the 1950s, is involved in catabolism of monoamines that are influenced by psychotropic medications, including neuroleptics and antidepressants.	monoamines	103-113	catechol-O-methyltransferase	Homo sapiens	11-40
16505837-1	2006	The enzyme catechol-O-methyl transferase (COMT), identified in the 1950s, is involved in catabolism of monoamines that are influenced by psychotropic medications, including neuroleptics and antidepressants.	monoamines	103-113	catechol-O-methyltransferase	Homo sapiens	42-46
16515684-2	2006	The transporters for the monoamines dopamine, norepinephrine, and serotonin (DAT, NET, and SERT) are targets for several popular psychostimulant drugs of abuse.	monoamines	25-35	solute carrier family 6 member 3	Homo sapiens	77-80
16515684-2	2006	The transporters for the monoamines dopamine, norepinephrine, and serotonin (DAT, NET, and SERT) are targets for several popular psychostimulant drugs of abuse.	monoamines	25-35	solute carrier family 6 member 2	Homo sapiens	82-85
16515684-2	2006	The transporters for the monoamines dopamine, norepinephrine, and serotonin (DAT, NET, and SERT) are targets for several popular psychostimulant drugs of abuse.	monoamines	25-35	solute carrier family 6 member 4	Homo sapiens	91-95
16301178-0	2005	Sorting of vesicular monoamine transporter 2 to the regulated secretory pathway confers the somatodendritic exocytosis of monoamines.	monoamines	122-132	solute carrier family 18 member A2	Rattus norvegicus	11-44
16326835-1	2005	Vesicular monoamine transporter 1 (VMAT1) is an integral protein in the membrane of secretory vesicles of neuroendocrine and endocrine cells that allows the transport of biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles.	monoamines	179-189	solute carrier family 18 member A1	Homo sapiens	0-33
16326835-1	2005	Vesicular monoamine transporter 1 (VMAT1) is an integral protein in the membrane of secretory vesicles of neuroendocrine and endocrine cells that allows the transport of biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles.	monoamines	179-189	solute carrier family 18 member A1	Homo sapiens	35-40
16758646-2	2005	It was found that in animals with different behavior subjected to experimental neuroses the regulatory effects of CNS monoamines on proliferation and differentiation are mediated via adrenergic and erythropoietin-sensitive structures on erythroid stem cells.	monoamines	118-128	erythropoietin	Mus musculus	198-212
16237719-5	2005	Significant sex- and region-specific differences of amino acids and monoamines were found in the brain of wild-type and AQP4-knockout mice.	monoamines	68-78	aquaporin 4	Mus musculus	120-124
16353949-4	2005	Presynaptic plasma membrane transporters for 5-HT (SERT), NE (NET), and DA (DAT), respectively, control synaptic actions of these monoamines by rapidly clearing the released amine.	monoamines	130-140	solute carrier family 6 member 4	Homo sapiens	51-55
16353949-4	2005	Presynaptic plasma membrane transporters for 5-HT (SERT), NE (NET), and DA (DAT), respectively, control synaptic actions of these monoamines by rapidly clearing the released amine.	monoamines	130-140	solute carrier family 6 member 2	Homo sapiens	62-65
16085363-10	2005	Previous data reports that H2O2 inhibits dopamine transporter activity, suggesting that the decrease in catalase activity may potentiate the toxic mechanism of drugs that inhibit monoamines reuptake.	monoamines	179-189	catalase	Mus musculus	104-112
16353949-4	2005	Presynaptic plasma membrane transporters for 5-HT (SERT), NE (NET), and DA (DAT), respectively, control synaptic actions of these monoamines by rapidly clearing the released amine.	monoamines	130-140	solute carrier family 6 member 3	Homo sapiens	76-79
16392030-0	2005	Enhanced BDNF signaling is associated with an antidepressant-like behavioral response and changes in brain monoamines.	monoamines	107-117	brain derived neurotrophic factor	Mus musculus	9-13
16579396-3	2005	Our earlier studies in this regard revealed disruption of brain monoamines in hippocampus with severe cytotoxic effect on CA4 hippocampal neurons.	monoamines	64-74	carbonic anhydrase 4	Homo sapiens	122-125
16129496-1	2005	The vesicular monoamine transporter (VMAT2) is important in the storage and release of monoamines.	monoamines	87-97	solute carrier family 18 member A2	Homo sapiens	37-42
15923360-8	2005	MAOB is active in degrading monoamines.	monoamines	28-38	monoamine oxidase B	Rattus norvegicus	0-4
15923360-9	2005	Therefore, MAOB may influence the insulin-secretory process by regulating the stores of monoamines in the B cells.	monoamines	88-98	monoamine oxidase B	Rattus norvegicus	11-15
16083857-1	2005	The human sulfotransferase, SULT1A3, catalyzes specifically the sulfonation of monoamines such as dopamine, epinephrine, and norepinephrine.	monoamines	79-89	sulfotransferase family 1A member 3	Homo sapiens	28-35
16148437-9	2005	Recent biochemical and behavioural findings have demonstrated that blockade of CB1 receptors engenders antidepressant-like neurochemical changes (increases in extracellular levels of monoamines in cortical but not subcortical brain regions) and behavioural effects consistent with antidepressant/antistress activity in rodents.	monoamines	183-193	cannabinoid receptor 1 (brain)	Mus musculus	79-82
15993437-0	2005	Carrier-mediated release of monoamines induced by the nicotinic acetylcholine receptor agonist DMPP.	monoamines	28-38	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	54-86
15961331-4	2005	Electrophysiological studies have shown that orexin neurons are regulated by monoamines and acetylcholine as well as metabolic cues, including leptin, glucose, and ghrelin.	monoamines	77-87	hypocretin neuropeptide precursor	Homo sapiens	45-51
15888529-1	2005	Bath-applied monoamines-dopamine (DA), serotonin (5-HT), and noradrenaline (NE)-strongly suppress the perforant path (PP) input to CA1 hippocampal region with very little effect on the Schaffer collaterals (SC) input.	monoamines	13-23	carbonic anhydrase 1	Homo sapiens	131-134
16211406-1	2005	The non-neuronal monoamine transporters OCT1, OCT2 and EMT (human gene symbols SLC22A1-A3) efficiently transport a number of positively-charged monoamines and some small organic cations across the plasma membrane, and thus are implicated in the inactivation of released monoamine transmitters (e.g. noradrenaline, histamine, agmatine) in vivo.	monoamines	144-154	solute carrier family 22 member 1	Homo sapiens	40-44
16211406-1	2005	The non-neuronal monoamine transporters OCT1, OCT2 and EMT (human gene symbols SLC22A1-A3) efficiently transport a number of positively-charged monoamines and some small organic cations across the plasma membrane, and thus are implicated in the inactivation of released monoamine transmitters (e.g. noradrenaline, histamine, agmatine) in vivo.	monoamines	144-154	solute carrier family 22 member 2	Homo sapiens	46-50
15948180-1	2005	A high density of opioid receptor-like 1 (ORL1) receptor (also referred to as NOP receptor) is found in limbic areas and in regions containing monoamines, which are implicated in emotional activity and physiopathology of depression and anxiety.	monoamines	143-153	opioid related nociceptin receptor 1	Rattus norvegicus	18-40
15948180-1	2005	A high density of opioid receptor-like 1 (ORL1) receptor (also referred to as NOP receptor) is found in limbic areas and in regions containing monoamines, which are implicated in emotional activity and physiopathology of depression and anxiety.	monoamines	143-153	opioid related nociceptin receptor 1	Rattus norvegicus	42-46
16211406-1	2005	The non-neuronal monoamine transporters OCT1, OCT2 and EMT (human gene symbols SLC22A1-A3) efficiently transport a number of positively-charged monoamines and some small organic cations across the plasma membrane, and thus are implicated in the inactivation of released monoamine transmitters (e.g. noradrenaline, histamine, agmatine) in vivo.	monoamines	144-154	IL2 inducible T cell kinase	Homo sapiens	55-58
16211406-1	2005	The non-neuronal monoamine transporters OCT1, OCT2 and EMT (human gene symbols SLC22A1-A3) efficiently transport a number of positively-charged monoamines and some small organic cations across the plasma membrane, and thus are implicated in the inactivation of released monoamine transmitters (e.g. noradrenaline, histamine, agmatine) in vivo.	monoamines	144-154	solute carrier family 22 member 1	Homo sapiens	79-86
15763139-2	2005	The cocaine and tricyclic antidepressant-sensitive NET belongs to a family of sodium and chloride coupled transporters that include the monoamines dopamine and serotonin and the amino acids GABA and glycine.	monoamines	136-146	solute carrier family 6 member 2	Homo sapiens	51-54
15829504-1	2005	The vesicular monoamine transporter 2 (VMAT2, SLC18A2) takes up cytosolic monoamines into intracellular secretory vesicles, preventing their neurotoxicity in the cytosol and discharging them into extracellular space by exocytosis.	monoamines	74-84	solute carrier family 18 member A2	Homo sapiens	4-37
15829504-1	2005	The vesicular monoamine transporter 2 (VMAT2, SLC18A2) takes up cytosolic monoamines into intracellular secretory vesicles, preventing their neurotoxicity in the cytosol and discharging them into extracellular space by exocytosis.	monoamines	74-84	solute carrier family 18 member A2	Homo sapiens	39-44
15829504-1	2005	The vesicular monoamine transporter 2 (VMAT2, SLC18A2) takes up cytosolic monoamines into intracellular secretory vesicles, preventing their neurotoxicity in the cytosol and discharging them into extracellular space by exocytosis.	monoamines	74-84	solute carrier family 18 member A2	Homo sapiens	46-53
15911148-1	2005	The organic cation transporter-3 (OCT3) can transport monoamines, similar to neuronal monoamine transporters.	monoamines	54-64	solute carrier family 22 (organic cation transporter), member 3	Mus musculus	4-32
15911148-1	2005	The organic cation transporter-3 (OCT3) can transport monoamines, similar to neuronal monoamine transporters.	monoamines	54-64	solute carrier family 22 (organic cation transporter), member 3	Mus musculus	34-38
15593317-9	2005	VMAT2 expression is important for the exocytosis of bioactive monoamines in neurons.	monoamines	62-72	solute carrier family 18 member A2	Homo sapiens	0-5
15620407-4	2005	Electrophysiological studies have shown that orexin neurons are regulated by humoral factors, including leptin, glucose, and ghrelin as well as monoamines and acetylcholin.	monoamines	144-154	hypocretin neuropeptide precursor	Homo sapiens	45-51
15365683-1	2005	RATIONALE: Galanin and its receptors exert inhibitory neuromodulatory control over brain monoamines.	monoamines	89-99	galanin and GMAP prepropeptide	Mus musculus	11-18
15496457-1	2005	The neuronal isoform of vesicular monoamine transporter, VMAT2, is responsible for packaging dopamine and other monoamines into synaptic vesicles and thereby plays an essential role in dopamine neurotransmission.	monoamines	112-122	solute carrier family 18 (vesicular monoamine), member 2	Mus musculus	57-62
15272015-0	2004	A spontaneous point mutation produces monoamine oxidase A/B knock-out mice with greatly elevated monoamines and anxiety-like behavior.	monoamines	97-107	monoamine oxidase A	Mus musculus	38-57
15500961-10	2004	Mutations at NR1 N616, NR2B N615, and NR2B N616, but not at NR1 W563 and NR1 N650, reduced the inhibitory effects by monoamines.	monoamines	117-127	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	13-16
15500961-10	2004	Mutations at NR1 N616, NR2B N615, and NR2B N616, but not at NR1 W563 and NR1 N650, reduced the inhibitory effects by monoamines.	monoamines	117-127	glutamate receptor ionotropic, NMDA 2B	Xenopus laevis	23-27
15500961-10	2004	Mutations at NR1 N616, NR2B N615, and NR2B N616, but not at NR1 W563 and NR1 N650, reduced the inhibitory effects by monoamines.	monoamines	117-127	glutamate receptor ionotropic, NMDA 2B	Xenopus laevis	38-42
12969236-0	2003	Influence of monoamines on differentiating gonadotropin-releasing hormone neurones in foetal mice.	monoamines	13-23	gonadotropin releasing hormone 1	Mus musculus	43-73
15212460-2	2004	There are two forms of PSTs for the sulfation of small phenols (PST-P) and monoamines (PST-M).	monoamines	75-85	sulfotransferase family 1A member 1	Homo sapiens	23-26
15093949-2	2004	AADC is the second-step synthesizing enzyme for monoamines and is also the rate-limiting enzyme of phenylethylamine (PEA) synthesis.	monoamines	48-58	dopa decarboxylase	Homo sapiens	0-4
18969305-1	2004	Several derivatization procedures with o-phthaldialdehyde-N-acetylcysteine (OPA-NAC) were compared for a rapid analysis of primary aliphatic short-chain monoamines in water samples by HPLC using a LiChorospher analytical separation column (100RP(18)125 mm x4 mm i.d., 5mum).	monoamines	153-163	synuclein alpha	Homo sapiens	80-83
12969236-5	2003	The total number of GnRH neurones in the forebrain in knockout mice was significantly lower compared to C3H mice, suggesting an inhibiting influence of monoamines on the proliferation of precursor cells.	monoamines	152-162	gonadotropin releasing hormone 1	Mus musculus	20-24
15099932-0	2004	Effect of long-term blockade of CRF(1) receptors on exploratory behaviour, monoamines and transcription factor AP-2.	monoamines	75-85	corticotropin releasing hormone receptor 1	Homo sapiens	32-38
14988048-2	2004	Thus, we examined whether monoamines affect on GDNF release in C6 cells.	monoamines	26-36	glial cell derived neurotrophic factor	Rattus norvegicus	47-51
15456951-2	2004	SSAO catalyzes the deamination of primary monoamines and has been suggested to be a risk factor in vascular disorders, e.g., diabetic vascular complications.	monoamines	42-52	amine oxidase copper containing 2	Homo sapiens	0-4
14697907-3	2004	Various mammalian tissues contain membrane-bound SSAO which metabolizes only the primary monoamines.	monoamines	89-99	amine oxidase copper containing 2	Homo sapiens	49-53
12969236-1	2003	This study evaluated the influence of monoamines, serotonin (5-hydroxytryptamine, 5-HT) and noradrenaline, on differentiating gonadotropin-releasing hormone (GnRH)-producing neurones in foetal mice.	monoamines	38-48	gonadotropin releasing hormone 1	Mus musculus	126-156
12855685-1	2003	Monoamine oxidase (MAO) A and B catalyze the oxidative deamination of neuroactive and dietary monoamines such as serotonin, tyramine, and phenylethylamine.	monoamines	94-104	monoamine oxidase A	Homo sapiens	0-25
12821174-1	2003	We tested fluoxetine, bupropion and GR 205171, a selective neurokinin-1 receptor antagonist on forced swimming test (FST) response and on levels of monoamines in frontal cortex of CD1 mice by microdialysis techniques.	monoamines	148-158	CD1 antigen complex	Mus musculus	180-183
12943557-4	2003	Several genes involved in brainstem CNS transmitter systems, especially the monoamines, have AP-2 binding sites in their regulatory regions.	monoamines	76-86	fatty acid binding protein 4	Rattus norvegicus	93-97
12871047-9	2003	Physiological substrates for EMT include the monoamines serotonin, dopamine, noradrenaline, adrenaline and histamine.	monoamines	45-55	solute carrier family 22 member 3	Homo sapiens	29-32
12871984-1	2003	The uptake of monoamines into the secretory granules of monoamine-storing neuroendocrine cells is mediated by vesicular monoamine transporter protein 1 or 2 (VMAT1 or VMAT2).	monoamines	14-24	solute carrier family 18 member A1	Homo sapiens	158-163
12871984-1	2003	The uptake of monoamines into the secretory granules of monoamine-storing neuroendocrine cells is mediated by vesicular monoamine transporter protein 1 or 2 (VMAT1 or VMAT2).	monoamines	14-24	solute carrier family 18 member A2	Homo sapiens	167-172
12871984-9	2003	The mutually exclusive expression of VMAT1 in EC cells and of VMAT2 in beta-cells suggests that both cell types store monoamines.	monoamines	118-128	solute carrier family 18 member A1	Homo sapiens	37-42
12871984-11	2003	In contrast, many insulinomas appear to lose their ability to accumulate monoamines via VMAT2.	monoamines	73-83	solute carrier family 18 member A2	Homo sapiens	88-93
12806206-6	2003	Recent electrophysiological studies have shown that orexin neurons are regulated by metabolic cues, including leptin, glucose, and ghrelin, as well as monoamines and acetylcholin.	monoamines	151-161	hypocretin neuropeptide precursor	Homo sapiens	52-58
12726820-0	2003	Alpha2-adrenergic drug effects on brain monoamines, locomotion, and body temperature are largely abolished in mice lacking the alpha2A-adrenoceptor subtype.	monoamines	40-50	adrenergic receptor, alpha 2a	Mus musculus	127-147
12802045-3	2003	Intracellular storage of monoamines involves vesicular transporter proteins (VMAT1 and VMAT2).	monoamines	25-35	solute carrier family 18 member A1	Homo sapiens	77-82
12802045-3	2003	Intracellular storage of monoamines involves vesicular transporter proteins (VMAT1 and VMAT2).	monoamines	25-35	solute carrier family 18 member A2	Homo sapiens	87-92
12710012-9	2003	This is in keeping with a role for VMAT2 in other cellular processes (i.e., sequestration and release from the cell of potential toxic products), in addition to its importance for the quantal release of monoamines.	monoamines	203-213	solute carrier family 18 member A2	Homo sapiens	35-40
12354632-6	2002	NET and SERT expressed at the BBB may be involved in the inactivation of monoamines released from neurons around the BBB.	monoamines	73-83	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	Mus musculus	0-3
12591135-8	2003	Since the VMAT2 is responsible for the intracellular storage and regulated release of monoamines, the reduced [(3)H]TBZOH binding levels in limbic brain regions of FSL rats may imply a reduced density of vesicular monoamine transporters, which can result in reduced monoamine transmission.	monoamines	86-96	solute carrier family 18 member A2	Rattus norvegicus	10-15
12532650-1	2002	INTRODUCTION: Recent data suggest that the copper-containing semicarbazide-sensitive amine oxidase enzyme (SSAO) may play a role in vascular endothelial damage through conversion of certain endogenous monoamines, like methylamine into cytotoxic aldehydes, hydrogen peroxide and ammonia.	monoamines	201-211	amine oxidase copper containing 2	Homo sapiens	61-105
12532650-1	2002	INTRODUCTION: Recent data suggest that the copper-containing semicarbazide-sensitive amine oxidase enzyme (SSAO) may play a role in vascular endothelial damage through conversion of certain endogenous monoamines, like methylamine into cytotoxic aldehydes, hydrogen peroxide and ammonia.	monoamines	201-211	amine oxidase copper containing 2	Homo sapiens	107-111
12450634-1	2002	The intraneuronal uptake of monoamines into brain synaptic vesicles is mediated by the vesicular monoamine transporter (VMAT2).	monoamines	28-38	solute carrier family 18 member A2	Homo sapiens	120-125
12450634-7	2002	The increased platelet VMAT2 density may reflect depression-related enhancement of the capacity to accumulate monoamines in the vesicles in the presence of lower monoamine turnover.	monoamines	110-120	solute carrier family 18 member A2	Homo sapiens	23-28
15035818-2	2003	The ability of SSAO to metabolise various aliphatic and aromatic monoamines differs between species, which limits the predictive value of the animal studies for human tissues.	monoamines	65-75	amine oxidase copper containing 2	Homo sapiens	15-19
15035818-3	2003	SSAO plays a protective role because the oxidative deamination of monoamines reduces their pharmacological activities.	monoamines	66-76	amine oxidase copper containing 2	Homo sapiens	0-4
12354632-6	2002	NET and SERT expressed at the BBB may be involved in the inactivation of monoamines released from neurons around the BBB.	monoamines	73-83	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	8-12
11882917-9	2002	In summary, we conclude that morphine addiction is associated with supersensitivity of 5-HT1A serotonin receptors and alpha2-adrenoceptors (autoreceptors and heteroreceptors) that modulate the synthesis of monoamines in brain.	monoamines	206-216	5-hydroxytryptamine receptor 1A	Rattus norvegicus	87-93
12126874-1	2002	Vesicular monoamine transporter (VMAT2) plays a major role in the synaptic accumulation and release of monoamines.	monoamines	103-113	solute carrier family 18 member A2	Homo sapiens	33-38
12162542-11	2002	We propose that the O2*- generation and Asc* formation in the Hb solution are due to the pseudoperoxidase activity-dependent oxidation of PEA and resultant ROS may damage tissues rich in monoamines, if the Hb-based blood substitutes were circulated without addition of ROS scavengers such as thiols.	monoamines	187-197	PYD and CARD domain containing	Homo sapiens	40-44
12021833-2	2002	Corticotropin-releasing factor (CRF), a neurotransmitter that is released during stress, and CRF receptors are expressed in areas of the brain which contribute to PPI, and central administration of CRF changes extracellular concentrations of the monoamines.	monoamines	246-256	corticotropin releasing hormone	Rattus norvegicus	0-30
11877331-15	2002	These results suggest imidazoline I(2) site ligands produce a common discriminable stimulus that appears associated with reversible inhibition of MAO-A rather than MAO-B, possibly through increases in extracellular concentration of one or more monoamines.	monoamines	244-254	monoamine oxidase A	Rattus norvegicus	146-151
12168505-0	2002	The effects of peptide and nonpeptide antagonists of angiotensin II receptors on the level of brain biogenic monoamines in rats with angiotensin II-induced increase of water intake.	monoamines	109-119	angiotensinogen	Rattus norvegicus	53-67
12168505-0	2002	The effects of peptide and nonpeptide antagonists of angiotensin II receptors on the level of brain biogenic monoamines in rats with angiotensin II-induced increase of water intake.	monoamines	109-119	angiotensinogen	Rattus norvegicus	133-147
12168505-1	2002	The effects of peptide and nonpeptide angiotensin II (Ang II)-receptor antagonists (losartan, EXP-3174, saralasin and sarmesin) on the levels of the biogenic monoamines dopamine, noradrenaline and serotonin in the frontal cortex, striatum, hypothalamus and hippocampus of rats with Ang II-induced water intake were investigated.	monoamines	158-168	angiotensinogen	Rattus norvegicus	38-52
11880481-2	2002	The aim of the current study was to investigate whether these monoamines are also able to influence AVP and OT expression in the paraventricular (PVN) and supraoptic nuclei (SON).	monoamines	62-72	arginine vasopressin	Mus musculus	100-103
11684350-4	2001	Several regionally specific correlations were found between AP-2alpha and AP-2beta and specific monoamines in the rat forebrain.	monoamines	96-106	transcription factor AP-2 alpha	Rattus norvegicus	60-69
11813239-1	2002	Human alpha(2)-macroglobulin (alpha(2)M), pregnancy zone protein (PZP), rat alpha(1)M and acute-phase rat alpha(2)M belong to the alpha(2)M gene family of proteins, which can react covalently with nucleophilic monoamines to yield monoamine-activated (MA) macroglobulins.	monoamines	210-220	alpha-2-macroglobulin	Rattus norvegicus	6-28
11813239-1	2002	Human alpha(2)-macroglobulin (alpha(2)M), pregnancy zone protein (PZP), rat alpha(1)M and acute-phase rat alpha(2)M belong to the alpha(2)M gene family of proteins, which can react covalently with nucleophilic monoamines to yield monoamine-activated (MA) macroglobulins.	monoamines	210-220	alpha-2-macroglobulin	Rattus norvegicus	30-39
11813239-1	2002	Human alpha(2)-macroglobulin (alpha(2)M), pregnancy zone protein (PZP), rat alpha(1)M and acute-phase rat alpha(2)M belong to the alpha(2)M gene family of proteins, which can react covalently with nucleophilic monoamines to yield monoamine-activated (MA) macroglobulins.	monoamines	210-220	alpha-2-macroglobulin	Rattus norvegicus	106-115
11813239-1	2002	Human alpha(2)-macroglobulin (alpha(2)M), pregnancy zone protein (PZP), rat alpha(1)M and acute-phase rat alpha(2)M belong to the alpha(2)M gene family of proteins, which can react covalently with nucleophilic monoamines to yield monoamine-activated (MA) macroglobulins.	monoamines	210-220	alpha-2-macroglobulin	Rattus norvegicus	106-115
11750910-4	2002	To this aim, we performed an immunohistochemistry study with an antibody raised against tyrosine hydroxylase (TH), the rate-limited step enzyme in the biosynthesis of monoamines.	monoamines	167-177	tyrosine hydroxylase	Rattus norvegicus	88-108
11750910-4	2002	To this aim, we performed an immunohistochemistry study with an antibody raised against tyrosine hydroxylase (TH), the rate-limited step enzyme in the biosynthesis of monoamines.	monoamines	167-177	tyrosine hydroxylase	Rattus norvegicus	110-112
11689160-6	2001	METH produced a significant decrease in striatal dopamine level, reaching a very low level after 24 h. Striatal serotonin level significantly increased and returned to control levels after 2 h. These data show that METH induced egr-1 and c-fos mRNA expression in selective brain areas, which correlated with an alteration in monoamines.	monoamines	325-335	early growth response 1	Mus musculus	228-233
11517274-4	2001	VMAT2 ko mice, completely lacking activity-dependent vesicular release of monoamines including 5-HT, also show a complete lack of 5-HT in the cortex but display largely normal barrel fields, despite sometimes markedly reduced postnatal growth.	monoamines	74-84	solute carrier family 18 (vesicular monoamine), member 2	Mus musculus	0-5
11669473-2	2001	The vesicular monoamine transporter (VMAT2) is responsible for the accumulation of monoamines in the synaptic vesicles.	monoamines	83-93	solute carrier family 18 member A2	Homo sapiens	37-42
11519142-5	2001	Antiepileptic drugs such as SSRI and tricyclic antidepressants bind with serotonin transporter(SERT), noradrenaline transporter(NET) and/or dopamine transporters(DAT) to inhibit transport of monoamines into the cytoplasma, thereby increasing monoamine levels within the synaptic cleft.	monoamines	191-201	solute carrier family 6 member 4	Homo sapiens	73-94
11463816-3	2001	Specifically, these animals express very low levels of VMAT2, an endogenous protein which sequesters monoamines intracellularly into vesicles, a process that, in addition to being important in normal transmission, may also act to keep intracellular levels of the monoamine neurotransmitters below potentially toxic thresholds.	monoamines	101-111	solute carrier family 18 (vesicular monoamine), member 2	Mus musculus	55-60
11519142-5	2001	Antiepileptic drugs such as SSRI and tricyclic antidepressants bind with serotonin transporter(SERT), noradrenaline transporter(NET) and/or dopamine transporters(DAT) to inhibit transport of monoamines into the cytoplasma, thereby increasing monoamine levels within the synaptic cleft.	monoamines	191-201	solute carrier family 6 member 4	Homo sapiens	95-99
11519142-5	2001	Antiepileptic drugs such as SSRI and tricyclic antidepressants bind with serotonin transporter(SERT), noradrenaline transporter(NET) and/or dopamine transporters(DAT) to inhibit transport of monoamines into the cytoplasma, thereby increasing monoamine levels within the synaptic cleft.	monoamines	191-201	solute carrier family 6 member 3	Homo sapiens	140-166
11443533-1	2001	The synaptic vesicular monoamine transporter (SVMT), alternatively vesicular monoamine transporter 2 (VMAT2), pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles.	monoamines	126-136	solute carrier family 18 member A2	Homo sapiens	4-44
11454337-1	2001	Epimerization of aldoses at C-2 has been extensively investigated by using various metal ions in conjunction with diamines, monoamines, and aminoalcohols.	monoamines	124-134	complement C2	Homo sapiens	28-31
11454337-2	2001	Aldoses are epimerized at C-2 by a combination of alkaline-earth or rare-earth metal ions (Ca(2+), Sr(2+), Pr(3+), or Ce(3+)) and such monoamines as triethylamine.	monoamines	135-145	complement C2	Homo sapiens	26-29
11443533-1	2001	The synaptic vesicular monoamine transporter (SVMT), alternatively vesicular monoamine transporter 2 (VMAT2), pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles.	monoamines	126-136	solute carrier family 18 member A2	Homo sapiens	46-50
11443533-1	2001	The synaptic vesicular monoamine transporter (SVMT), alternatively vesicular monoamine transporter 2 (VMAT2), pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles.	monoamines	126-136	solute carrier family 18 member A2	Homo sapiens	67-100
11443533-1	2001	The synaptic vesicular monoamine transporter (SVMT), alternatively vesicular monoamine transporter 2 (VMAT2), pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles.	monoamines	126-136	solute carrier family 18 member A2	Homo sapiens	102-107
11264240-2	2001	This study was designed to assess the molecular and cellular events involved in the up-regulation (and receptor supersensitivity) of brain alpha(2)-adrenoceptors as a result of chronic depletion of noradrenaline (and other monoamines) by reserpine.	monoamines	223-233	adrenoceptor alpha 2A	Rattus norvegicus	139-161
11406127-0	2001	Effect of embryonic knock-down of GABAA receptors on the levels of monoamines and their metabolites in the CNS of the mouse.	monoamines	67-77	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	34-39
11384203-10	2001	The obtained results indicate that in rat brain amygdala, of all the monoamines, dopamine seems to be the most important modulator of NPY biosynthesis and expression.	monoamines	69-79	neuropeptide Y	Rattus norvegicus	134-137
21318776-49	2001	Genetic deletion of VMAT2 reveals the essential role of vesicular storage and release of monoamines.	monoamines	89-99	solute carrier family 18 (vesicular monoamine), member 2	Mus musculus	20-25
11173067-4	2001	This effect was significantly potentiated by selective monoamine oxidase A and B inhibition, suggesting that central monoamines, known to be substrates of these enzymes may be released.	monoamines	117-127	monoamine oxidase A	Mus musculus	55-74
11156689-1	2001	Semicarbazide-sensitive amine oxidase (SSAO), widely distributed in highly vascularized mammalian tissues, metabolizes endogenous and xenobiotic aromatic and aliphatic monoamines.	monoamines	168-178	amine oxidase copper containing 2	Homo sapiens	0-37
11156689-1	2001	Semicarbazide-sensitive amine oxidase (SSAO), widely distributed in highly vascularized mammalian tissues, metabolizes endogenous and xenobiotic aromatic and aliphatic monoamines.	monoamines	168-178	amine oxidase copper containing 2	Homo sapiens	39-43
11031490-1	2000	The effect of the ultralow power pulse-modulated electromagnetic radiation (EMR, power density 10 microW/cm2; carrying frequency 915 MHz; modulating pulses with frequency 2, 4, 6, 8, 12, 16 and 20 Hz) on activity of monoamine oxidase (MAO-A), enzyme involved in the oxidative deamination of monoamines, was investigated.	monoamines	291-301	monoamine oxidase A	Rattus norvegicus	216-233
9882615-1	1999	Uptake and storage of monoamines in secretory granules is accomplished by vesicular monoamine transporters, and it is likely that vesicular monoamine transporter 2 (VMAT2) is important for histamine transport in vivo.	monoamines	22-32	solute carrier family 18 member A2	Rattus norvegicus	130-163
10619653-1	1999	GTP cyclohydrolase I (GTPCH) catalyzes the first and rate-limiting reaction in the synthesis of tetrahydrobiopterin (BH4), an obligatory co-factor for monoamines and nitric oxide syntheses.	monoamines	151-161	NGG1 interacting factor 3 like 1	Bos taurus	0-20
10619653-1	1999	GTP cyclohydrolase I (GTPCH) catalyzes the first and rate-limiting reaction in the synthesis of tetrahydrobiopterin (BH4), an obligatory co-factor for monoamines and nitric oxide syntheses.	monoamines	151-161	NGG1 interacting factor 3 like 1	Bos taurus	22-27
10370887-5	1999	These properties could be due to the capacity to increase the cerebral monoamines by the 5-HT2A and alpha 2 antagonism.	monoamines	71-81	5-hydroxytryptamine receptor 2A	Homo sapiens	89-95
10876805-3	2000	This mini-review focuses on the issues (1) how the immune system transmits information to the brain and (2) how pro-inflammatory cytokines, interleukin-1 in particular, alter the activities of monoamines (catecholamines and serotonin) and some peptides (CRF, alpha MSH) for the manifestation of acute phase responses.	monoamines	193-203	interleukin 1 alpha	Homo sapiens	140-153
10463334-11	1999	Therefore, most imidazoline drugs modulated the synthesis of brain monoamines through interaction with alpha2-adrenoceptors or 5-HT1A receptors.	monoamines	67-77	5-hydroxytryptamine receptor 1A	Rattus norvegicus	127-133
9882615-1	1999	Uptake and storage of monoamines in secretory granules is accomplished by vesicular monoamine transporters, and it is likely that vesicular monoamine transporter 2 (VMAT2) is important for histamine transport in vivo.	monoamines	22-32	solute carrier family 18 member A2	Rattus norvegicus	165-170
10363820-1	1999	The effects of systemically administered interleukin-1beta (1.0 microg), interleukin-6 (1.0 microg) and interleukin-2 (1.0 microg) on in vivo variations of monoamines were assessed in the nucleus accumbens.	monoamines	156-166	interleukin 1 beta	Rattus norvegicus	41-58
9972846-6	1999	Baseline levels of VMN monoamines (pg/10 microl dialysate) in IL-1alpha and vehicle groups were similar.	monoamines	23-33	interleukin 1 alpha	Rattus norvegicus	62-71
10363820-1	1999	The effects of systemically administered interleukin-1beta (1.0 microg), interleukin-6 (1.0 microg) and interleukin-2 (1.0 microg) on in vivo variations of monoamines were assessed in the nucleus accumbens.	monoamines	156-166	interleukin 6	Rattus norvegicus	73-86
10363820-1	1999	The effects of systemically administered interleukin-1beta (1.0 microg), interleukin-6 (1.0 microg) and interleukin-2 (1.0 microg) on in vivo variations of monoamines were assessed in the nucleus accumbens.	monoamines	156-166	interleukin 2	Rattus norvegicus	104-117
10093500-8	1998	It may provide a link between the function of monoamines during stress, and the control of water balance by ANP.	monoamines	46-56	natriuretic peptide A	Homo sapiens	108-111
10385927-3	1998	The obtained results suggest that monoamines take part in the regulation of NPY expression in amygdala neurons of rat brain, and that elimination of these monoaminergic regulation leads to an increase in the NPY content in that structure.	monoamines	34-44	neuropeptide Y	Rattus norvegicus	76-79
9771557-9	1998	Few treatment differences were observed, with the 0.1 mg/kg body weight T-2, 2% of the LD50, significantly affecting brain monoamines.	monoamines	123-133	brachyury 2	Rattus norvegicus	72-75
9766386-1	1998	The purpose of this study was to examine specificity in the effects of interleukin-1beta (IL-1beta) on monoamines in various areas of the hypothalamus.	monoamines	103-113	interleukin 1 beta	Rattus norvegicus	71-88
9766386-1	1998	The purpose of this study was to examine specificity in the effects of interleukin-1beta (IL-1beta) on monoamines in various areas of the hypothalamus.	monoamines	103-113	interleukin 1 beta	Rattus norvegicus	90-98
9595272-2	1998	Monoamines do not form coordination bonds with a preformed iron-serotonin-binding protein (SBP) complex, as initially believed.	monoamines	0-10	spermine binding protein	Rattus norvegicus	91-94
9733951-16	1998	VMAT1 mRNA expression may reflect a specific effect of monoamines in glial differentiation and cerebellar granule cell migration and/or differentiation.	monoamines	55-65	solute carrier family 18 member A1	Rattus norvegicus	0-5
9767465-0	1998	Role of mast cells and monoamines in the thrombocytopaenia and mortality elicited by tumour necrosis factor in mice.	monoamines	23-33	tumor necrosis factor	Mus musculus	85-107
9767465-5	1998	TNF-induced thrombocytopaenia was markedly attenuated in mice treated with reserpine, an agent that depletes monoamines from mast cells and other cells, and in the mast-cell-deficient WWv mice.	monoamines	109-119	tumor necrosis factor	Mus musculus	0-3
9767465-10	1998	These results indicate that TNF can induce a release of monoamines from mast cells, mainly from those of the small intestine, a process that contributes to TNF-induced thrombocytopaenia and mortality.	monoamines	56-66	tumor necrosis factor	Mus musculus	28-31
9767465-10	1998	These results indicate that TNF can induce a release of monoamines from mast cells, mainly from those of the small intestine, a process that contributes to TNF-induced thrombocytopaenia and mortality.	monoamines	56-66	tumor necrosis factor	Mus musculus	156-159
9725894-2	1998	Both monoamines and diamines block Kir2.1 channels, with potency increasing as the alkyl chain length increases (from 2 to 12 methylene groups), indicating a strong hydrophobic interaction with the blocking site.	monoamines	5-15	potassium inwardly rectifying channel subfamily J member 2 L homeolog	Xenopus laevis	35-41
9595272-3	1998	Instead, metals oxidize the monoamines either directly (manganese, copper) or by oxygen free radical formation (iron), the oxidation products bind covalently to SBP and the conjugates are able to undergo redox cycling.	monoamines	28-38	spermine binding protein	Rattus norvegicus	161-164
9695933-2	1998	High levels of these monoamines within the VMH have been suspected to induce obesity and insulin resistance.	monoamines	21-31	insulin	Mesocricetus auratus	89-96
9665836-16	1998	Interestingly, the presence of VMAT2 in vesicles underlying dendrites, axons, and soma suggests that monoamines may be released at these cellular domains.	monoamines	101-111	solute carrier family 18 member A2	Homo sapiens	31-36
9638660-10	1998	One indication for specialized CSF analyses including biogenic monoamines and GABA is severe neonatal/infantile epileptic encephalopathy.	monoamines	63-73	colony stimulating factor 2	Homo sapiens	31-34
9605161-8	1998	Based on the 83% identity between the isolated cDNA and human VAP-1 cDNA, the expression pattern, the molecular mass, and the enzyme activity against monoamines, the cloned molecule represents a mouse homologue of human VAP-1.	monoamines	150-160	amine oxidase copper containing 3	Homo sapiens	220-225
9406893-5	1997	Like the monoamines, collagen-induced A beta release was concentration-dependent, maximal stimulated release exceeding basal efflux by 184%.	monoamines	9-19	amyloid beta precursor protein	Homo sapiens	38-44
9427250-1	1997	To assess the role of exocytotic release in signaling by monoamines, we have disrupted the neuronal vesicular monoamine transporter 2 (VMAT2) gene.	monoamines	57-67	solute carrier family 18 (vesicular monoamine), member 2	Mus musculus	135-140
9349821-7	1997	Comparison of this vesicular GABA transporter (VGAT) with a vesicular transporter for monoamines shows that there are differences in the bioenergetic dependence of transport, and these presumably account for the differences in structure.	monoamines	86-96	solute carrier family 6 member 12	Rattus norvegicus	19-45
9349821-7	1997	Comparison of this vesicular GABA transporter (VGAT) with a vesicular transporter for monoamines shows that there are differences in the bioenergetic dependence of transport, and these presumably account for the differences in structure.	monoamines	86-96	solute carrier family 6 member 12	Rattus norvegicus	47-51
9366248-0	1997	Activation of intestinal mitochondrial phospholipase D by polyamines and monoamines.	monoamines	73-83	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	39-54
9366248-1	1997	Intestinal mitochondria have a phospholipase D (PLD) activity which was stimulated by polyamines and monoamines resulting in the formation of phosphatidic acid (PA) from endogenous phospholipids.	monoamines	101-111	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	31-46
9366248-1	1997	Intestinal mitochondria have a phospholipase D (PLD) activity which was stimulated by polyamines and monoamines resulting in the formation of phosphatidic acid (PA) from endogenous phospholipids.	monoamines	101-111	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	48-51
9366248-2	1997	When stimulated by polyamines, mitochondrial PLD utilized endogenous phosphatidylethanolamine (PE) as substrate whereas stimulated by monoamines, both PE and phosphatidylcholine (PC) were hydrolysed.	monoamines	134-144	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	45-48
9272630-0	1997	Thyrotropin releasing hormone prevents abnormalities of cortical acetylcholine and monoamines in mice following head injury.	monoamines	83-93	thyrotropin releasing hormone	Mus musculus	0-29
9387858-1	1997	The principal brain vesicular monoamine transporter (VMAT2) pumps monoamines including dopamine, norepinephrine, serotonin and histamine from neuronal cytoplasm into synaptic vesicles and is implicated in actions of certain psychostimulants and selective neurotoxins.	monoamines	66-76	solute carrier family 18 (vesicular monoamine), member 2	Mus musculus	53-58
9325148-11	1997	P-PST prefers p-nitrophenol as substrate, is sensitive to inhibition by DCNP, and is thermostable; in contrast, M-PST prefers monoamines as substrate, is not sensitive to DCNP, and is thermolabile.	monoamines	126-136	mercaptopyruvate sulfurtransferase	Homo sapiens	112-117
9252020-1	1997	The effects of systemically administered interleukin-1beta (1.0 microg) on in vivo variations of monoamines was assessed in several brain regions.	monoamines	97-107	interleukin 1 beta	Rattus norvegicus	41-58
9272630-1	1997	We investigated the effects of thyrotropin releasing hormone (TRH) on changes in cortical concentrations of acetylcholine (ACh) and monoamines produced by concussion in mice.	monoamines	132-142	thyrotropin releasing hormone	Mus musculus	31-60
9272630-1	1997	We investigated the effects of thyrotropin releasing hormone (TRH) on changes in cortical concentrations of acetylcholine (ACh) and monoamines produced by concussion in mice.	monoamines	132-142	thyrotropin releasing hormone	Mus musculus	62-65
9203554-2	1997	These monoamines are catabolised mainly by the enzyme monoamine oxidase (MAO) which exists in two isoforms; MAO-A and MAO-B.	monoamines	6-16	monoamine oxidase A	Rattus norvegicus	54-71
9131778-1	1997	The vesicular monoamine transporter-2 (VMAT2) mediates the reserpine-sensitive neuronal uptake of monoamines into vesicles and other intracellular organelles.	monoamines	98-108	solute carrier family 18 member A2	Rattus norvegicus	4-37
9131778-1	1997	The vesicular monoamine transporter-2 (VMAT2) mediates the reserpine-sensitive neuronal uptake of monoamines into vesicles and other intracellular organelles.	monoamines	98-108	solute carrier family 18 member A2	Rattus norvegicus	39-44
9203554-2	1997	These monoamines are catabolised mainly by the enzyme monoamine oxidase (MAO) which exists in two isoforms; MAO-A and MAO-B.	monoamines	6-16	monoamine oxidase A	Rattus norvegicus	73-76
9203554-2	1997	These monoamines are catabolised mainly by the enzyme monoamine oxidase (MAO) which exists in two isoforms; MAO-A and MAO-B.	monoamines	6-16	monoamine oxidase A	Rattus norvegicus	108-113
9203554-2	1997	These monoamines are catabolised mainly by the enzyme monoamine oxidase (MAO) which exists in two isoforms; MAO-A and MAO-B.	monoamines	6-16	monoamine oxidase B	Rattus norvegicus	118-123
8622973-8	1996	VMAT2 is found on large dense-core vesicles but not on the small synaptic vesicles that contain VAChT in PC12-c4 cells, despite the presence of VMAT2 immunoreactivity in central and peripheral nerve terminals known to contain monoamines in small synaptic vesicles.	monoamines	226-236	solute carrier family 18 member A2	Rattus norvegicus	0-5
9160974-3	1997	Increased concentrations of the monoamines within the forebrain regions studied at days 7 and 15, suggest a hastened maturation of these neural systems in animals neonatally treated with ACTH.	monoamines	32-42	proopiomelanocortin	Homo sapiens	187-191
9387528-1	1996	OBJECTIVE: To study the changes of plasma levels of monoamines in pregnant women and investigate the relationship between the monoamines and pregnancy induced hypertension (PIH).	monoamines	126-136	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	173-176
9387528-7	1996	CONCLUSION: The changes of monoamines may be one of the causes of small artery spasm in PIH.	monoamines	27-37	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	88-91
8829205-1	1996	The effects of intravenous injections of thyrotropin-releasing hormone and its analog NS-3 (montirelin hydrate, CG3703) on the dynamics of brain monoamines were examined in mice and rats.	monoamines	145-155	thyrotropin releasing hormone	Mus musculus	41-70
8829205-1	1996	The effects of intravenous injections of thyrotropin-releasing hormone and its analog NS-3 (montirelin hydrate, CG3703) on the dynamics of brain monoamines were examined in mice and rats.	monoamines	145-155	mal, T-cell differentiation protein	Rattus norvegicus	86-90
9159177-1	1997	Mice deficient in monoamine oxidase A (MAOA), an enzyme that metabolizes monoamines such as norepinephrine and serotonin, have elevated norepinephrine and serotonin levels in the frontal cortex, hippocampus, and cerebellum, compared with normal wild-type mice.	monoamines	73-83	monoamine oxidase A	Mus musculus	18-37
9159177-1	1997	Mice deficient in monoamine oxidase A (MAOA), an enzyme that metabolizes monoamines such as norepinephrine and serotonin, have elevated norepinephrine and serotonin levels in the frontal cortex, hippocampus, and cerebellum, compared with normal wild-type mice.	monoamines	73-83	monoamine oxidase A	Mus musculus	39-43
9159177-6	1997	These results suggest that chronic elevations of monoamines, due to a deletion of the gene encoding MAOA, lead to selective alterations in emotional behavior.	monoamines	49-59	monoamine oxidase A	Mus musculus	100-104
8916076-6	1996	Our results provide further evidence that VMAT2 is the vesicular amine transporter responsible for accumulation of monoamines into secretory vesicles of monoaminergic neurons and ECL cells.	monoamines	115-125	solute carrier family 18 member A2	Rattus norvegicus	42-47
8858935-6	1996	In developing DA neurons, an 80% increase in TH activity was found only after co-treatment with aFGF (100 ng/ml) and DA (1 microM) or other monoamines.	monoamines	140-150	tyrosine hydroxylase	Rattus norvegicus	45-47
8752590-7	1996	[Ca2+]i responses to monoamines and histamine did not require the presence of extracellular Ca2+ and they were blocked by preincubation of slices with thapsigargin (500 nM), indicating that the [Ca2+]i responses were recorded after application of aspartate, bradykinin, dopamine, GABA, glycine, oxytocin, serotonin, somatostatin, substance P, taurine or vasopressin.	monoamines	21-31	tachykinin 1	Mus musculus	330-341
8698885-9	1996	The localization of CYP2D1 in several regions known to harbor catecholamines and serotonin may suggest a role for CYP2D1 in the metabolism of monoamines.	monoamines	142-152	cytochrome P450, family 2, subfamily d, polypeptide 1	Rattus norvegicus	20-26
8860658-1	1996	Monoamine oxidases (MAO-A and MAO-B) are enzymes that play a key role in the degradation of endogenous and dietary monoamines.	monoamines	115-125	monoamine oxidase A	Homo sapiens	20-25
8860658-1	1996	Monoamine oxidases (MAO-A and MAO-B) are enzymes that play a key role in the degradation of endogenous and dietary monoamines.	monoamines	115-125	monoamine oxidase B	Homo sapiens	30-35
8698885-9	1996	The localization of CYP2D1 in several regions known to harbor catecholamines and serotonin may suggest a role for CYP2D1 in the metabolism of monoamines.	monoamines	142-152	cytochrome P450, family 2, subfamily d, polypeptide 1	Rattus norvegicus	114-120
8606801-9	1995	However, replacement of serines in the third transmembrane domain of VMAT2 that have been shown to be essential for recognition of other monoamines also eliminate 3H-histamine transport, suggesting that these serine residues may do more than simply recognize the hydroxyl groups on a monoamine substrate.	monoamines	137-147	solute carrier family 18 member A2	Homo sapiens	69-74
8592129-0	1996	Antagonism of serotonin 5-HT1A receptors potentiates the increases in extracellular monoamines induced by duloxetine in rat hypothalamus.	monoamines	84-94	5-hydroxytryptamine receptor 1A	Rattus norvegicus	24-30
7552306-5	1995	The inhibitory effects of IL-1 beta and LPS were significantly prevented by genistein, a selective tyrosine kinase antagonist, and by H7, a potent inhibitor of protein kinase C. These results indicate that IL-1 beta and LPS inhibit 5-HT2 receptor-mediated Ca2+ mobilization via pathways that include the activation of a tyrosine kinase and protein kinase C. The interaction between cytokines (IL-1 beta) and monoamines (5-HT) may serve to modulate signal transduction in the central nervous system.	monoamines	408-418	interleukin 1 beta	Rattus norvegicus	26-35
8868059-0	1995	The antiopioid peptide, neuropeptide FF, enhances the effects of acute morphine on the cerebral monoamines in rats.	monoamines	96-106	neuropeptide FF-amide peptide precursor	Rattus norvegicus	24-39
8868059-1	1995	The effects of neuropeptide FF (NPFF) on the changes induced by acute morphine in cerebral monoamines were studied in male Wistar rats.	monoamines	91-101	neuropeptide FF-amide peptide precursor	Rattus norvegicus	32-36
8868059-8	1995	In conclusion, our results suggest that NPFF does not attenuate but rather enhances the changes induced by acute morphine in the cerebral monoamines.	monoamines	138-148	neuropeptide FF-amide peptide precursor	Rattus norvegicus	40-44
7592763-7	1995	The results suggest that by analogy to receptors and plasma membrane transporters for monoamines, the cationic amino group of the ligand interacts with an asparte in the first transmembrane domain of VMAT2 and hydroxyl groups on the catechol or indole ring interact with a group of serines in the third transmembrane domain.	monoamines	86-96	solute carrier family 18 member A2	Homo sapiens	200-205
7552306-5	1995	The inhibitory effects of IL-1 beta and LPS were significantly prevented by genistein, a selective tyrosine kinase antagonist, and by H7, a potent inhibitor of protein kinase C. These results indicate that IL-1 beta and LPS inhibit 5-HT2 receptor-mediated Ca2+ mobilization via pathways that include the activation of a tyrosine kinase and protein kinase C. The interaction between cytokines (IL-1 beta) and monoamines (5-HT) may serve to modulate signal transduction in the central nervous system.	monoamines	408-418	interleukin 1 beta	Rattus norvegicus	206-215
7552306-5	1995	The inhibitory effects of IL-1 beta and LPS were significantly prevented by genistein, a selective tyrosine kinase antagonist, and by H7, a potent inhibitor of protein kinase C. These results indicate that IL-1 beta and LPS inhibit 5-HT2 receptor-mediated Ca2+ mobilization via pathways that include the activation of a tyrosine kinase and protein kinase C. The interaction between cytokines (IL-1 beta) and monoamines (5-HT) may serve to modulate signal transduction in the central nervous system.	monoamines	408-418	interleukin 1 beta	Rattus norvegicus	206-215
7695637-1	1995	Thermolabile (TL) phenol sulfotransferase (PST) catalyzes the sulfate conjugation of phenolic monoamines such as dopamine.	monoamines	94-104	sulfotransferase family 1A member 1	Homo sapiens	43-46
7617706-0	1995	Alterations in brain monoamines and GABAA receptors in transgenic mice overexpressing TGF alpha.	monoamines	21-31	transforming growth factor alpha	Mus musculus	86-95
7572278-6	1995	Epo elevated monoamines in PC12 cells.	monoamines	13-23	erythropoietin	Rattus norvegicus	0-3
7962100-4	1994	To localize the transporter that packages monoamines into secretory vesicles, we have raised antibodies to a COOH-terminal sequence from the vesicular amine transporter expressed in the adrenal gland (VMAT1).	monoamines	42-52	solute carrier family 18 member A1	Rattus norvegicus	201-206
7931249-8	1994	Increases of tissue and extracellular concentrations of NA and 5HT were highest after Pargyline suggesting that both monoamines may be metabolized by MAO-A and MAO-B.	monoamines	117-127	monoamine oxidase A	Rattus norvegicus	150-155
8302852-2	1994	dSERT1 shows little transport of other monoamines and is Na+ and Cl- dependent.	monoamines	39-49	Serotonin transporter	Drosophila melanogaster	0-6
7725832-2	1994	For this aim, neuropeptide gene expression has been evaluated by in situ hybridization in targets for monoamines, differentiating peptidergic neurons, after monoamine depletion in rats during prenatal or early postnatal periods.	monoamines	102-112	pyroglutamylated RFamide peptide	Rattus norvegicus	14-26
7825905-5	1994	The GR was present in neuronal populations with classical neurotransmitters, especially monoamines and glutamate and with various neuropeptides.	monoamines	88-98	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	4-6
7802419-15	1994	However, recent research has shown that GABA, the monoamines, and several neuropeptides are participants in the estrogen-sensitive network which regulates GNRH secretion.	monoamines	50-60	gonadotropin releasing hormone 1	Homo sapiens	155-159
7931249-8	1994	Increases of tissue and extracellular concentrations of NA and 5HT were highest after Pargyline suggesting that both monoamines may be metabolized by MAO-A and MAO-B.	monoamines	117-127	monoamine oxidase B	Rattus norvegicus	160-165
8327559-0	1993	Effects of calcitonin on CNS monoamines following carrageenan-induced inflammation in rats.	monoamines	29-39	calcitonin-related polypeptide alpha	Rattus norvegicus	11-21
8330200-1	1993	Monoamine oxidase A and B (MAO A and B; EC 1.4.3.4) are integral proteins of the outer mitochondrial membrane that degrade monoamines including the neurotransmitters norepinephrine, dopamine, and serotonin.	monoamines	123-133	monoamine oxidase A	Rattus norvegicus	0-25
8330200-1	1993	Monoamine oxidase A and B (MAO A and B; EC 1.4.3.4) are integral proteins of the outer mitochondrial membrane that degrade monoamines including the neurotransmitters norepinephrine, dopamine, and serotonin.	monoamines	123-133	monoamine oxidase A	Rattus norvegicus	27-38
7510140-1	1993	It was shown that the permanent magnetic fields at 35-40 mT1 inhibit the activity of biogenic monoamines in developing amphibian embryos.	monoamines	94-104	brachyury, T-box transcription factor T	Mus musculus	57-60
7686585-9	1993	We conclude that alpha 2M can potentially interact with nucleophilic monoamines, including neurotransmitters, to form inhibitory complexes which may inhibit/regulate NGF-promoted neurite outgrowth and neuronal survival.	monoamines	69-79	alpha-2-macroglobulin	Rattus norvegicus	17-25
7686585-9	1993	We conclude that alpha 2M can potentially interact with nucleophilic monoamines, including neurotransmitters, to form inhibitory complexes which may inhibit/regulate NGF-promoted neurite outgrowth and neuronal survival.	monoamines	69-79	nerve growth factor	Rattus norvegicus	166-169
7684373-8	1993	The addition of Epo to the culture media of PC12 cells elevated the intracellular concentrations of monoamines.	monoamines	100-110	erythropoietin	Rattus norvegicus	16-19
8327559-1	1993	The present study examined the effects of systemically administered calcitonin (CT, 10 IU/0.25 ml, SC) on changes in CNS monoamines (MAs) following unilateral carrageenan (CARRA)-induced inflammation in the rat hindpaw.	monoamines	121-131	calcitonin-related polypeptide alpha	Rattus norvegicus	68-78
7509158-2	1993	By analysis of monoamines and their metabolites in the dialysate, dopamine-derived 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines were found to inhibit monoamine oxidase and catechol-O-methyltransferase activity.	monoamines	15-25	catechol-O-methyltransferase	Rattus norvegicus	173-201
8099814-0	1993	Monoamines and their metabolites in Huntington"s disease brain: evidence for decreased catechol-O-methyltransferase activity.	monoamines	0-10	catechol-O-methyltransferase	Homo sapiens	87-115
8473003-0	1993	Effect of dietary T-2 toxin on biogenic monoamines in discrete areas of the rat brain.	monoamines	40-50	brachyury 2	Rattus norvegicus	18-21
8473003-2	1993	In this study, the effect of dietary T-2 toxin on regional brain concentrations of biogenic monoamines and their metabolites was investigated in male rats fed a semi-synthetic diet containing 0, 2.5 or 10 ppm T-2 toxin for either 7 or 14 days.	monoamines	92-102	brachyury 2	Rattus norvegicus	37-40
8473003-9	1993	The observed effects of T-2 toxin on brain monoamines and the resulting neurochemical imbalance may account for the physiological manifestation of trichothecene intoxication.	monoamines	43-53	brachyury 2	Rattus norvegicus	24-27
8459190-2	1993	Since the release of pituitary GH is neurally regulated by the hypothalamus, GH autoregulation may be mediated by changes in the content or metabolism of hypothalamic monoamines.	monoamines	167-177	growth hormone	Gallus gallus	31-33
8459190-2	1993	Since the release of pituitary GH is neurally regulated by the hypothalamus, GH autoregulation may be mediated by changes in the content or metabolism of hypothalamic monoamines.	monoamines	167-177	growth hormone	Gallus gallus	77-79
1816091-0	1991	Effect of intracerebroventricularly administered insulin on brain monoamines and acetylcholine in euglycaemic and alloxan-induced hyperglycaemic rats.	monoamines	66-76	insulin	Homo sapiens	49-56
1727435-0	1992	Stathmin phosphorylation is regulated in striatal neurons by vasoactive intestinal peptide and monoamines via multiple intracellular pathways.	monoamines	95-105	stathmin 1	Homo sapiens	0-8
1640798-2	1992	We used brain microdialysis and on-line HPLC to examine the effect of ET-3 on the basal outflow of monoamines and their metabolites in the ketamine-anaesthetised rat striatum in vivo.	monoamines	99-109	endothelin 3	Rattus norvegicus	70-74
1617531-3	1992	A microdialysis probe was stereotaxically implanted in the C1 area to dialyze monoamines during intravenous administration of met-enkephalin.	monoamines	78-88	proenkephalin	Rattus norvegicus	130-140
1816091-10	1991	The present study reports for the first time the likely interaction between CNS insulin receptors and brain monoamines, and ACh, in euglycaemic and hyperglycaemic states.	monoamines	108-118	insulin	Homo sapiens	80-87
1710400-0	1990	[The relationship between free-running period and monoamines in the SCN].	monoamines	50-60	sodium voltage-gated channel alpha subunit 2	Rattus norvegicus	68-71
1683687-0	1991	Chronic treatment with D1 and D2 dopamine receptor agonists: combined treatments interact to differentially affect brain levels of monoamines.	monoamines	131-141	dopamine receptor D2	Rattus norvegicus	30-50
1687013-3	1991	One form of PST is thermostable (TS) and catalyzes the sulfation of "simple" phenols such as p-nitrophenol, while the other form is thermolabile (TL) and catalyzes the sulfate conjugation of phenolic monoamines such as dopamine.	monoamines	200-210	sulfotransferase family 1A member 1	Homo sapiens	12-15
2071588-9	1991	The physiological role of E1 and E2 isozymes could be in dehydrogenation of aldehyde metabolites of monoamines such as 3,4-dihydroxyphenylacetaldehyde or 5-hydroxyindoleacetaldehyde; the catalytic efficiency with these substrates is better with E1 and E2 isozymes than with E3 isozyme.	monoamines	100-110	small nucleolar RNA, H/ACA box 73A	Homo sapiens	26-35
2071588-9	1991	The physiological role of E1 and E2 isozymes could be in dehydrogenation of aldehyde metabolites of monoamines such as 3,4-dihydroxyphenylacetaldehyde or 5-hydroxyindoleacetaldehyde; the catalytic efficiency with these substrates is better with E1 and E2 isozymes than with E3 isozyme.	monoamines	100-110	small nucleolar RNA, H/ACA box 73A	Homo sapiens	245-254
1710791-0	1991	Possible involvement of hypothalamic monoamines in mediating the action of alpha-2u-globulin on the pituitary-testicular axis in rats.	monoamines	37-47	alpha2u globulin	Rattus norvegicus	75-92
1980457-0	1990	Evaluation of toluene exposure via drinking water on levels of regional brain biogenic monoamines and their metabolites in CD-1 mice.	monoamines	87-97	CD1 antigen complex	Mus musculus	123-127
2291808-12	1990	The results indicate that milk removal and prolactin release induced by milking or suckling in lactating ewes is inhibited by an increase in monoamines at the hypothalamic-hypophyseal level.	monoamines	141-151	prolactin	Homo sapiens	43-52
1698242-8	1990	These results indicate that administration of alpha-2u-globulin can lead to a significant stimulation of pituitary-testicular axis and that this effect may be mediated through alteration of hypothalamic monoamines.	monoamines	203-213	major urinary protein 19	Mus musculus	46-63
1981283-10	1990	It is likely that monoamines and neuropeptides act in the IML, as in other area of the central nervous system, as neuromodulators to set the level of excitability of SPN rather than relaying sympathetic information over a functionally specific medullospinal pathway.	monoamines	18-28	DEAF1 transcription factor	Homo sapiens	166-169
19215368-13	1990	Since the changes are present in areas where activity of rnonoaminergic systems is critical for initiating gonadotrophin surges and inducing lordosis behavior, these results provide initial evidence that catabolism of monoamines by MAO may contribute to rnonoaminergic regulation of reproductive function.	monoamines	218-228	monoamine oxidase A	Rattus norvegicus	232-235
2323731-0	1990	Monoamine oxidase A mediates iodotyrosine formation induced by monoamines in bovine thyroid particulate fraction.	monoamines	63-73	monoamine oxidase A	Bos taurus	0-19
2351370-0	1990	Interaction of cholecystokinin and diazepam: effects on brain monoamines.	monoamines	62-72	cholecystokinin	Rattus norvegicus	15-30
18823757-3	2008	Sult4A1 is related to metabolism of monoamines, particularly dopamine and norepinephrine, both of which have been implicated in the pathophysiology of the psychopathology and cognitive dysfunction components of schizophrenia.	monoamines	36-46	sulfotransferase family 4A member 1	Homo sapiens	0-7
2476695-1	1989	Corticotropin-releasing factor (CRF) was injected into the lateral hypothalamus of conscious unrestrained rats and the local concentration of monoamines in the vicinity of the microinjection monitored by microdialysis.	monoamines	142-152	corticotropin releasing hormone	Rattus norvegicus	0-30
34727322-3	2021	Reserpine functions by inhibiting vesicular monoamine transporter 2 (VMAT2), reducing sequestration of monoamines into synaptic vesicles.	monoamines	103-113	solute carrier family 18 member A2	Rattus norvegicus	69-74
34782122-4	2022	Monoamine oxidase A (MAOA) (X p11.23) plays a crucial role in the metabolism of monoamines.	monoamines	80-90	monoamine oxidase A	Homo sapiens	0-19
34782122-4	2022	Monoamine oxidase A (MAOA) (X p11.23) plays a crucial role in the metabolism of monoamines.	monoamines	80-90	monoamine oxidase A	Homo sapiens	21-25
34224763-3	2021	Previous studies have demonstrated that the soluble N-ethylmaleimide-sensitive fusion attachment protein receptor (SNARE) protein syntaxin 1A (STX1A) regulates the secretion of OXT and monoamines, and that STX1A gene knockout (STX1A KO) mice exhibit atypical social behavior, such as deficient social recognition, due to reduced OXT release.	monoamines	185-195	N-ethylmaleimide sensitive fusion protein attachment protein alpha	Mus musculus	115-120
34224763-3	2021	Previous studies have demonstrated that the soluble N-ethylmaleimide-sensitive fusion attachment protein receptor (SNARE) protein syntaxin 1A (STX1A) regulates the secretion of OXT and monoamines, and that STX1A gene knockout (STX1A KO) mice exhibit atypical social behavior, such as deficient social recognition, due to reduced OXT release.	monoamines	185-195	syntaxin 1A (brain)	Mus musculus	130-141
34224763-3	2021	Previous studies have demonstrated that the soluble N-ethylmaleimide-sensitive fusion attachment protein receptor (SNARE) protein syntaxin 1A (STX1A) regulates the secretion of OXT and monoamines, and that STX1A gene knockout (STX1A KO) mice exhibit atypical social behavior, such as deficient social recognition, due to reduced OXT release.	monoamines	185-195	syntaxin 1A (brain)	Mus musculus	143-148
34489696-4	2021	Here, we examined a possible functional role of FFAR1 in the control of extracellular concentrations of striatal monoamines and cocaine-induced locomotor activity.	monoamines	113-123	free fatty acid receptor 1	Mus musculus	48-53
34052887-9	2022	Unfortunately, we lack a unified mechanism to explain PSD which mechanisms now involve dysregulation of hypothalamic-pituitary-adrenal (HPA) axis, increased inflammatory factors, decreased levels of monoamines, glutamate-mediated excitotoxicity, and abnormal neurotrophic response.	monoamines	199-209	F-box and leucine rich repeat protein 15	Homo sapiens	54-57
2601684-4	1989	The other form of PST is thermolabile and catalyzes the sulfate conjugation of micromolar concentrations of dopamine and other phenolic monoamines.	monoamines	136-146	sulfotransferase family 1A member 1	Homo sapiens	18-21
2488972-6	1989	A high performance liquid chromatography (HPLC) was used for detecting alteration of monoamines and prostaglandins in the rat brain on sedative state after BK or KAL injection.	monoamines	85-95	kallikrein related-peptidase 5 like	Rattus norvegicus	162-165
2582707-2	1989	All human tissues studied contain a thermostable (TS) form of PST, which catalyzes the sulfate conjugation of "simple" phenols such as p-nitrophenol, and a thermolabile (TL) form, which catalyzes the sulfation of dopamine and other monoamines.	monoamines	232-242	sulfotransferase family 1A member 1	Homo sapiens	62-65
2456770-2	1988	In addition, SP may modulate the release of nigrostriatal monoamines, which have also been linked with avoidance learning.	monoamines	58-68	tachykinin precursor 1	Homo sapiens	13-15
2477116-4	1989	When NPY was injected into the lateral hypothalamus and monoamines measured from areas adjacent to the injection of NPY there was a significant increase in norepinephrine release and a significant increase in the concentration of DOPAC.	monoamines	56-66	neuropeptide Y	Rattus norvegicus	116-119
2565962-5	1989	Overall MDL 72145 was selectively more active against membrane bound SSAO enzymes that deaminate primary monoamines.	monoamines	105-115	amine oxidase, copper containing 3	Rattus norvegicus	69-73
2691927-4	1989	Insulin appears to have effects on monoamines opposite to that of chronic hyperglycemia.	monoamines	35-45	insulin	Homo sapiens	0-7
3264161-8	1988	MPP+ is the first quaternary ammonium salt shown to be a substrate of the monoamine transporter and it has the same pH-dependency as monoamines.	monoamines	133-143	solute carrier family 18 member A2	Homo sapiens	74-95
3141816-1	1988	The accumulation rates of 3,4"-dihydroxyphenylalanine (DOPA) and 5-hydroxytryptophan (5-HTP) after inhibition of aromatic amino acid decarboxylase (AADC) by 3-hydroxybenzylhydrazine (NSD 1015) or 1-(DL-seryl)-2- (2,3,4-trihydroxybenzyl)hydrazine (Ro 4-4602) have widely been used as measurements of the in vivo synthesis rates of monoamines.	monoamines	330-340	dopa decarboxylase	Rattus norvegicus	148-152
2568453-1	1989	Monoamines with from 1 to 18 straight chain carbon atoms have been analysed as rat liver monoamine oxidase substrates.	monoamines	0-10	monoamine oxidase A	Rattus norvegicus	89-106
3237308-1	1988	We compared the changes in monoamines and their metabolites in the El mouse brain induced by GABA-A and GABA-B receptor agonists.	monoamines	27-37	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	93-99
2904998-7	1988	The rate of accumulation of brain 5-HT and NA were enhanced during carrageenan inflammation, indicating that the turnover of these monoamines is augmented during the inflammatory process.	monoamines	131-141	POU class 6 homeobox 1	Rattus norvegicus	28-35
19651087-8	1988	The possibility that the NE or 5-HT effects involve the oxidative metabolism of the monoamines by MAO was also investigated.	monoamines	84-94	monoamine oxidase A	Rattus norvegicus	98-101
2453262-0	1988	Effect of T-2 toxin on brain biogenic monoamines in rats and chickens.	monoamines	38-48	brachyury 2	Rattus norvegicus	10-13
2453262-1	1988	Two experiments were conducted to determine the effect of T-2 toxin on brain biogenic monoamines and their metabolites.	monoamines	86-96	brachyury 2	Rattus norvegicus	58-61
3162871-5	1988	A thermostable (TS) form of PST catalyzes the sulfate conjugation of micromolar concentrations of p-nitrophenol, and a thermolabile (TL) form catalyzes the sulfate conjugation of dopamine and other monoamines.	monoamines	198-208	sulfotransferase family 1A member 1	Homo sapiens	28-31
3103805-11	1987	It is concluded that while MAO inhibitors may be the primary compound responsible for MAO inhibition, the effects of their metabolites in some cases may also play equally important roles in the regulation of monoamines both in the periphery and the brain.	monoamines	208-218	monoamine oxidase A	Rattus norvegicus	27-30
2890184-0	1987	Somatostatin: peripheral venoconstrictive activity and interaction with monoamines in man.	monoamines	72-82	somatostatin	Homo sapiens	0-12
2445409-0	1987	CSF monoamines in autistic syndromes and other pervasive developmental disorders of early childhood.	monoamines	4-14	colony stimulating factor 2	Homo sapiens	0-3
2889675-2	1987	PRL secretion is undoubtedly influenced by many substances, which can be variously altered in uremia: monoamines, endogenous opiates and PTH.	monoamines	102-112	prolactin	Homo sapiens	0-3
2885774-1	1987	Cholecystokinin (CCK) and Bombesin (BBS) are two neuropeptides which induce changes in monoamines in the brain after peripheral administration.	monoamines	87-97	cholecystokinin	Rattus norvegicus	0-15
2885774-1	1987	Cholecystokinin (CCK) and Bombesin (BBS) are two neuropeptides which induce changes in monoamines in the brain after peripheral administration.	monoamines	87-97	cholecystokinin	Rattus norvegicus	17-20
3108386-2	1987	In the present report, we show that 5-HT as well as other monoamines, histamine and dopamine, modulate IFN-gamma-induced phagocytosis in murine bone marrow macrophages.	monoamines	58-68	interferon gamma	Mus musculus	103-112
2424272-6	1986	This result indicates the need for strict control of environment in studies of CSF monoamines and their metabolites.	monoamines	83-93	colony stimulating factor 2	Homo sapiens	79-82
3747266-3	1986	The alpha-methylated substrate-analogue monoamines, dl-alpha-methyltryptamine, dl-alpha-methylbenzylamine and two optical isomers of alpha-methylbenzylamine, were shown to be inhibitors of rat lung semicarbazide-sensitive amine oxidase (SSAO), with dl-alpha-methyltryptamine being the most potent and d-alpha-methylbenzylamine, the least.	monoamines	40-50	amine oxidase, copper containing 3	Rattus norvegicus	198-235
3747266-3	1986	The alpha-methylated substrate-analogue monoamines, dl-alpha-methyltryptamine, dl-alpha-methylbenzylamine and two optical isomers of alpha-methylbenzylamine, were shown to be inhibitors of rat lung semicarbazide-sensitive amine oxidase (SSAO), with dl-alpha-methyltryptamine being the most potent and d-alpha-methylbenzylamine, the least.	monoamines	40-50	amine oxidase, copper containing 3	Rattus norvegicus	237-241
3747266-8	1986	The present results indicate that SSAO can recognize optical isomers and that some alpha-methylated monoamines tested in the present study inhibit SSAO with properties different from those as MAO inhibitors.	monoamines	100-110	amine oxidase, copper containing 3	Rattus norvegicus	147-151
3747266-8	1986	The present results indicate that SSAO can recognize optical isomers and that some alpha-methylated monoamines tested in the present study inhibit SSAO with properties different from those as MAO inhibitors.	monoamines	100-110	monoamine oxidase A	Rattus norvegicus	192-195
3912671-0	1985	Influence of monoamines on content of luteinizing hormone-releasing hormone in different regions of the hypothalamus of male rats.	monoamines	13-23	gonadotropin releasing hormone 1	Rattus norvegicus	38-75
3817433-0	1986	Variability of changes in obese rat brain monoamines in response to cholecystokinin.	monoamines	42-52	cholecystokinin	Rattus norvegicus	68-83
2999285-5	1985	For the GnRH neurones the influence of endogenous opioid neurones, possibly the arcuate beta-endorphin system, appears to be mediated indirectly by inhibiting release of excitatory or facilitatory monoamines.	monoamines	197-207	gonadotropin releasing hormone 1	Homo sapiens	8-12
3861769-0	1985	Sulfate conjugation of monoamines in human brain: purification and some properties of an arylamine sulfotransferase from cerebral cortex.	monoamines	23-33	sulfotransferase family 1A member 2	Homo sapiens	89-115
3861769-1	1985	An arylamine sulfotransferase (PST-M) from human brain cortex that is involved in the formation of O-sulfate esters of monoamines has been purified 272-fold by ammonium sulfate fractionation, gel filtration, DEAE-cellulose ion-exchange chromatography, chromatofocussing, and hydroxyapatite chromatography.	monoamines	119-129	sulfotransferase family 1A member 2	Homo sapiens	3-29
3861769-1	1985	An arylamine sulfotransferase (PST-M) from human brain cortex that is involved in the formation of O-sulfate esters of monoamines has been purified 272-fold by ammonium sulfate fractionation, gel filtration, DEAE-cellulose ion-exchange chromatography, chromatofocussing, and hydroxyapatite chromatography.	monoamines	119-129	sulfotransferase family 1A member 1	Homo sapiens	31-34
6605176-4	1983	Present results support the notion of an inhibitory role of monoamines, particularly catecholamines, on the release of corticoliberin.	monoamines	60-70	corticotropin releasing hormone	Rattus norvegicus	119-133
3893467-4	1985	The presence of aldehyde dehydrogenase and aldehyde reductase in cerebral microvasculature is consistent with previous reports of enrichment of other enzymes involved in synthesis and degradation of monoamines.	monoamines	199-209	aldo-keto reductase family 1 member B1	Bos taurus	43-61
6380618-1	1984	Investigation of the effects of injecting monoamines (noradrenaline, dopamine and serotonin) into the third ventricle of the brain on the LH-RH content in the synaptosomal fraction of the mediobasal hypothalamus in intact and castrated male rats has demonstrated that all the three monoamines are involved in the regulation of synthesis and secretion of LH-RH and that their effects on LH-RH-producing neurons are steroid-dependent.	monoamines	42-52	gonadotropin releasing hormone 1	Rattus norvegicus	138-143
6377408-0	1984	[Effect of insulin-induced hypoglycemia on the metabolism of monoamines].	monoamines	61-71	insulin	Homo sapiens	11-18
3855967-4	1985	TS PST catalyzes the sulfate conjugation of micromolar concentrations of phenol and p-nitrophenol and TL PST catalyzes the sulfate conjugation of dopamine and other monoamines.	monoamines	165-175	sulfotransferase family 1A member 1	Homo sapiens	0-6
3855967-4	1985	TS PST catalyzes the sulfate conjugation of micromolar concentrations of phenol and p-nitrophenol and TL PST catalyzes the sulfate conjugation of dopamine and other monoamines.	monoamines	165-175	sulfotransferase family 1A member 3	Homo sapiens	102-108
4036650-6	1985	Evidently monoamine oxidase A plays a decisive role for controlling the level of the biogenic monoamines in the young organism during the first days of the ontogenesis.	monoamines	94-104	monoamine oxidase A	Rattus norvegicus	10-29
2582215-2	1985	This article reviews the relationship between the turnover of the neurotransmitter monoamines noradrenaline, serotonin, and dopamine, and the concentrations in CSF of their principal metabolites, 3-methoxy-4-hydroxyphenylglycol (MHPG), 5-hydroxyindoleacetic acid (5-HIAA), and homovanillic acid (HVA).	monoamines	83-93	colony stimulating factor 2	Homo sapiens	160-163
6589361-2	1984	The human blood platelet contains a thermolabile (TL) form of PST that catalyzes the sulfate conjugation of dopamine and other monoamines and a thermostable (TS) form that catalyzes the sulfate conjugation of micromolar concentrations of phenol and p-nitrophenol.	monoamines	127-137	sulfotransferase family 1A member 1	Homo sapiens	62-65
6318854-4	1983	One of the possible mechanisms underlying the action of beta-endorphin on the secretion of the hormones indicated might be the changes in the ratio of brain monoamines (a decrease in dopamine).	monoamines	157-167	proopiomelanocortin	Homo sapiens	56-70
7046838-8	1982	The effects of monoamines on LH-RH neurones is steroid-dependent.	monoamines	15-25	gonadotropin releasing hormone 1	Rattus norvegicus	29-34
6131439-9	1983	We conclude that neurotensin may play a role in short-term appetite regulation by a complex interaction with monoamines and neuropeptides, particularly norepinephrine and the kappa opiate agonist, dynorphin.	monoamines	109-119	neurotensin	Rattus norvegicus	17-28
6980883-6	1982	However, C4b exhibits a distinct preference for diamines, putrescine and 1,3-diaminopropane, over monoamines of the same alkyl chain length, s-butylamine and n-propylamine.	monoamines	98-108	complement C4B (Chido blood group)	Homo sapiens	9-12
6104306-3	1980	), an antagonist of brain monoamines, to rats that were passively immunized with antiserum to somatostatin immediately lowered plasma GH levels and inhibited episodic GH secretion.	monoamines	26-36	gonadotropin releasing hormone receptor	Rattus norvegicus	134-136
6781477-1	1980	Cultured mouse peritoneal macrophages were found to release substantial amounts of lysosomal beta-glucuronidase and beta-glactosidase activites when exposed to millimolar concentrations of various primary aliphatic monoamines.	monoamines	215-225	glucuronidase, beta	Mus musculus	93-111
7023253-2	1981	Because the monoamines dopamine and serotonin are important in the control of its secretion, prolactin has been the subject of much psychoendocrine research in recent years.	monoamines	12-22	prolactin	Homo sapiens	93-102
40668-0	1979	Nerve growth factor: effects on D-amphetamine-induced activity and brain monoamines.	monoamines	73-83	nerve growth factor	Rattus norvegicus	0-19
6268511-7	1980	Conflicting data have been published on the influence of monoamines on ACTH secretion.	monoamines	57-67	proopiomelanocortin	Canis lupus familiaris	71-75
7196369-4	1980	These diurnal changes of each MAO type activity may reflect the biological actions of monoamines in relation to a circadian rhythm of the neuroendocrinological system in the brain to some extent.	monoamines	86-96	monoamine oxidase A	Rattus norvegicus	30-33
7463880-0	1980	Effect of a cholecystokinin preparation on brain monoamines in the rat.	monoamines	49-59	cholecystokinin	Rattus norvegicus	12-27
7463880-3	1980	However, since a tendency to increase in norepinephrine turnover rate after CCK injection was noticed, the possibility that brain monoamines are involved in the central action of CCK could not be excluded.	monoamines	130-140	cholecystokinin	Rattus norvegicus	179-182
883159-4	1977	But the values of the dissociation constants of the intermediary complexes for both MAO types differed dramatically with alterations of the substituents at the nitrogen atom in molecules of the 2-propynylamine derivatives which probably determines the well recognized properties of the 2-propynylamine derivatives of causing highly selective inhibition of oxidative deamination of various biogenic monoamines.	monoamines	398-408	monoamine oxidase A	Rattus norvegicus	84-87
571377-3	1979	The important role of this enzyme in the regulation of the circulating levels of a number of monoamines known to have an inhibitory effect on insulin secretion may indicate the possible inclusion of the MAO/monoamine system in the pathophysiology of diabetes.	monoamines	93-103	insulin	Homo sapiens	142-149
202142-0	1977	Changes in conditioned reflex behaviour and brain monoamines to ACTH administration.	monoamines	50-60	proopiomelanocortin	Homo sapiens	64-68
185834-0	1976	[Participation of cerebral monoamines in hypothalamic regulation of ACTH secretion].	monoamines	27-37	proopiomelanocortin	Homo sapiens	68-72
10544-4	1976	The authors consider successively the implication of monoamines in the control of liberation of ACTH, GH, TSH, prolactin and gonadotropic hormones.	monoamines	53-63	proopiomelanocortin	Homo sapiens	96-100
4295-13	1975	We conclude that inhibition of islet MAO may cause an increase in islet monoamine content and these monoamines may alter in vitro insulin secretion.	monoamines	100-110	insulin	Oryctolagus cuniculus	130-137
187432-0	1975	Interference of inhibitors of dopamine-beta-hydroxylase with uptake of monoamines by chromaffin granular membranes.	monoamines	71-81	dopamine beta-hydroxylase	Bos taurus	30-55
33378168-3	2021	Alterations in the expression or activity of the vesicular monoamine transporter 2 (VMAT2), which transports monoamines such as dopamine from the cytosol into the synaptic vesicle, result in dysregulated dopamine packaging.	monoamines	109-119	solute carrier family 18 member A2	Homo sapiens	49-82
5819569-0	1969	Interaction of DOPA decarboxylase inhibitors with the effect of alpha-methyldopa on blood pressure and tissue monoamines in rats.	monoamines	110-120	dopa decarboxylase	Rattus norvegicus	15-33
13416302-2	1957	Monoamines as substrates of diamine oxidase.	monoamines	0-10	amine oxidase copper containing 1	Homo sapiens	28-43
24179066-3	1971	This paper reviews evidence indicating that menstrual cycle psychopathology may be mediated by the effects of estrogen, progesterone, and possibly the renin-angiotensin-aldosterone system on the brain monoamines, norepinephrine, dopamine, and serotonin.	monoamines	201-211	renin	Rattus norvegicus	151-156
6082152-0	1967	Activities of tryptophan hydroxylase, dopa decarboxylase, and monoamine oxidase as correlated with the appearance of monoamines in developing rat pineal gland.	monoamines	117-127	dopa decarboxylase	Rattus norvegicus	38-56
33378168-3	2021	Alterations in the expression or activity of the vesicular monoamine transporter 2 (VMAT2), which transports monoamines such as dopamine from the cytosol into the synaptic vesicle, result in dysregulated dopamine packaging.	monoamines	109-119	solute carrier family 18 member A2	Homo sapiens	84-89
33174440-2	2021	Vesicular monoamine transporter type 2 (VMAT2) inhibitors reduce dyskinesia by decreasing transport of monoamines, including dopamine, into presynaptic vesicles, leaving unpackaged dopamine to be metabolized by monoamine oxidase.	monoamines	103-113	solute carrier family 18 member A2	Homo sapiens	0-38
33174440-2	2021	Vesicular monoamine transporter type 2 (VMAT2) inhibitors reduce dyskinesia by decreasing transport of monoamines, including dopamine, into presynaptic vesicles, leaving unpackaged dopamine to be metabolized by monoamine oxidase.	monoamines	103-113	solute carrier family 18 member A2	Homo sapiens	40-45
32004521-2	2020	Proteoliposomes containing the purified human SLC18B1 protein transport not only monoamines, but also polyamines, such as spermidine (Spd) and spermine (Spm), using an electrochemical gradient of H+ established by vacuolar H+-ATPase (V-ATPase) as the driving force.	monoamines	81-91	solute carrier family 18 member B1	Homo sapiens	46-53
33262691-7	2020	Following a prenatal exposure to molecules that significantly elicit the MAOA gene expression, a daily treatment with the same metabolic impact would tend to recreate the fetal environment and contribute to rebalance monoamines, thus allowing proper neural circuits to gradually develop, provided behavioral re-education.	monoamines	217-227	monoamine oxidase A	Homo sapiens	73-77
33075479-5	2020	mTOR is a translation regulator involved in synaptic plasticity and is sensitive to many exercise signals such as monoamines, growth factors, and cellular metabolism.	monoamines	114-124	mechanistic target of rapamycin kinase	Homo sapiens	0-4
32826296-1	2020	Vesicular monoamine transporter 2 (VMAT2) uptakes cytoplasmic monoamines into vesicles for storage.	monoamines	62-72	solute carrier family 18 (vesicular monoamine), member 2	Mus musculus	0-33
32826296-1	2020	Vesicular monoamine transporter 2 (VMAT2) uptakes cytoplasmic monoamines into vesicles for storage.	monoamines	62-72	solute carrier family 18 (vesicular monoamine), member 2	Mus musculus	35-40
32178384-1	2020	Two members of the copper-containing amine oxidase family are physiologically important proteins: (1) Diamine oxidase (hDAO; AOC1) with a preference for diamines is involved in degradation of histamine and (2) Vascular adhesion protein-1 (hVAP-1; AOC3) with a preference for monoamines is a multifunctional cell-surface receptor and an enzyme.	monoamines	275-285	D-amino acid oxidase	Homo sapiens	119-123
32606350-0	2020	Gamma oryzanol impairs alcohol-induced anxiety-like behavior in mice via upregulation of central monoamines associated with Bdnf and Il-1beta signaling.	monoamines	97-107	brain derived neurotrophic factor	Mus musculus	124-128
32606350-0	2020	Gamma oryzanol impairs alcohol-induced anxiety-like behavior in mice via upregulation of central monoamines associated with Bdnf and Il-1beta signaling.	monoamines	97-107	interleukin 1 alpha	Mus musculus	133-141
32178384-1	2020	Two members of the copper-containing amine oxidase family are physiologically important proteins: (1) Diamine oxidase (hDAO; AOC1) with a preference for diamines is involved in degradation of histamine and (2) Vascular adhesion protein-1 (hVAP-1; AOC3) with a preference for monoamines is a multifunctional cell-surface receptor and an enzyme.	monoamines	275-285	amine oxidase copper containing 1	Homo sapiens	102-117
32178384-1	2020	Two members of the copper-containing amine oxidase family are physiologically important proteins: (1) Diamine oxidase (hDAO; AOC1) with a preference for diamines is involved in degradation of histamine and (2) Vascular adhesion protein-1 (hVAP-1; AOC3) with a preference for monoamines is a multifunctional cell-surface receptor and an enzyme.	monoamines	275-285	amine oxidase copper containing 1	Homo sapiens	125-129
32178384-1	2020	Two members of the copper-containing amine oxidase family are physiologically important proteins: (1) Diamine oxidase (hDAO; AOC1) with a preference for diamines is involved in degradation of histamine and (2) Vascular adhesion protein-1 (hVAP-1; AOC3) with a preference for monoamines is a multifunctional cell-surface receptor and an enzyme.	monoamines	275-285	amine oxidase copper containing 3	Homo sapiens	239-245
32178384-1	2020	Two members of the copper-containing amine oxidase family are physiologically important proteins: (1) Diamine oxidase (hDAO; AOC1) with a preference for diamines is involved in degradation of histamine and (2) Vascular adhesion protein-1 (hVAP-1; AOC3) with a preference for monoamines is a multifunctional cell-surface receptor and an enzyme.	monoamines	275-285	amine oxidase copper containing 3	Homo sapiens	247-251
31394142-0	2019	Estradiol and selective estrogen receptor agonists differentially affect brain monoamines and amino acids levels in transitional and surgical menopausal rat models.	monoamines	79-89	estrogen receptor 1	Rattus norvegicus	24-41
31476331-7	2019	The results of the present study suggest that dHPC 5-HT1A receptors regulate cognitive impairments in PD by changes of monoamines in the related brain regions.	monoamines	119-129	5-hydroxytryptamine receptor 1A	Rattus norvegicus	51-57
31322459-7	2020	Glucocorticoids and glucocorticoid-metabolizing enzymes interact closely with other biomolecules such as inflammatory cytokines, monoamines, and some monoamine-metabolizing enzymes, namely the monoamine oxidase type A (MAO-A) and B (MAO-B).	monoamines	129-139	monoamine oxidase A	Homo sapiens	193-217
31322459-7	2020	Glucocorticoids and glucocorticoid-metabolizing enzymes interact closely with other biomolecules such as inflammatory cytokines, monoamines, and some monoamine-metabolizing enzymes, namely the monoamine oxidase type A (MAO-A) and B (MAO-B).	monoamines	129-139	monoamine oxidase A	Homo sapiens	219-231
31322459-7	2020	Glucocorticoids and glucocorticoid-metabolizing enzymes interact closely with other biomolecules such as inflammatory cytokines, monoamines, and some monoamine-metabolizing enzymes, namely the monoamine oxidase type A (MAO-A) and B (MAO-B).	monoamines	129-139	monoamine oxidase B	Homo sapiens	233-238
31291696-1	2019	The two human monoamine oxidase isoforms (namely MAO A and MAO B) are enzymes involved in the catabolism of monoamines, including neurotransmitters, and for this reason are well-known and attractive pharmacological targets in neuropsychiatric and neurodegenerative diseases, for which novel pharmacological approaches are necessary.	monoamines	108-118	monoamine oxidase A	Homo sapiens	49-54
31291696-1	2019	The two human monoamine oxidase isoforms (namely MAO A and MAO B) are enzymes involved in the catabolism of monoamines, including neurotransmitters, and for this reason are well-known and attractive pharmacological targets in neuropsychiatric and neurodegenerative diseases, for which novel pharmacological approaches are necessary.	monoamines	108-118	monoamine oxidase B	Homo sapiens	59-64
29667298-1	2019	Monoamine oxidase-A (MAOA) metabolises monoamines and is implicated in the pathophysiology of psychiatric disorders.	monoamines	39-49	monoamine oxidase A	Homo sapiens	0-19
31270129-1	2019	Transporters of the solute carrier 6 (SLC6) family translocate their cognate substrate together with Na+ and Cl- Detailed kinetic models exist for the transporters of GABA (GAT1/SLC6A1) and the monoamines dopamine (DAT/SLC6A3) and serotonin (SERT/SLC6A4).	monoamines	194-204	solute carrier family 6 member 1	Homo sapiens	173-177
31270129-1	2019	Transporters of the solute carrier 6 (SLC6) family translocate their cognate substrate together with Na+ and Cl- Detailed kinetic models exist for the transporters of GABA (GAT1/SLC6A1) and the monoamines dopamine (DAT/SLC6A3) and serotonin (SERT/SLC6A4).	monoamines	194-204	solute carrier family 6 member 1	Homo sapiens	178-184
31270129-1	2019	Transporters of the solute carrier 6 (SLC6) family translocate their cognate substrate together with Na+ and Cl- Detailed kinetic models exist for the transporters of GABA (GAT1/SLC6A1) and the monoamines dopamine (DAT/SLC6A3) and serotonin (SERT/SLC6A4).	monoamines	194-204	solute carrier family 6 member 3	Homo sapiens	215-218
31270129-1	2019	Transporters of the solute carrier 6 (SLC6) family translocate their cognate substrate together with Na+ and Cl- Detailed kinetic models exist for the transporters of GABA (GAT1/SLC6A1) and the monoamines dopamine (DAT/SLC6A3) and serotonin (SERT/SLC6A4).	monoamines	194-204	solute carrier family 6 member 3	Homo sapiens	219-225
31270129-1	2019	Transporters of the solute carrier 6 (SLC6) family translocate their cognate substrate together with Na+ and Cl- Detailed kinetic models exist for the transporters of GABA (GAT1/SLC6A1) and the monoamines dopamine (DAT/SLC6A3) and serotonin (SERT/SLC6A4).	monoamines	194-204	solute carrier family 6 member 4	Homo sapiens	242-246
31270129-1	2019	Transporters of the solute carrier 6 (SLC6) family translocate their cognate substrate together with Na+ and Cl- Detailed kinetic models exist for the transporters of GABA (GAT1/SLC6A1) and the monoamines dopamine (DAT/SLC6A3) and serotonin (SERT/SLC6A4).	monoamines	194-204	solute carrier family 6 member 4	Homo sapiens	247-253
29667298-1	2019	Monoamine oxidase-A (MAOA) metabolises monoamines and is implicated in the pathophysiology of psychiatric disorders.	monoamines	39-49	monoamine oxidase A	Homo sapiens	21-25
31403080-0	2019	Altered CSF levels of monoamines in hereditary spastic paraparesis 10: A case series.	monoamines	22-32	colony stimulating factor 2	Homo sapiens	8-11
31240161-1	2019	Background: Brain monoamine vesicular transport disease is an infantile onset neurodevelopmental disorder caused by variants in SLC18A2, which codes for the vesicular monoamine transporter 2 (VMAT2) protein, involved in the transport of monoamines into synaptic vesicles and of serotonin into platelet dense granules.	monoamines	237-247	solute carrier family 18 member A2	Homo sapiens	128-135
31213631-5	2019	Following in vitro studies showing that monoamines inhibited Abeta aggregation, this in vivo study, in which RA intake increased concentration of monoamine by reducing Maob gene expression, builds on that knowledge by demonstrating that monoamines suppress Abeta aggregation.	monoamines	40-50	amyloid beta (A4) precursor protein	Mus musculus	61-66
30959896-4	2019	In the present work we studied ASIC3 modulation by a series of "hydrophobic monoamines" and their guanidine analogs, which were previously characterized to affect other ASIC channels via multiple mechanisms.	monoamines	76-86	acid-sensing ion channel 3	Cricetulus griseus	31-36
31174279-5	2019	P2X7R may modulate the release of several neurotransmitters, including monoamines, nitric oxide (NO) and glutamate.	monoamines	71-81	purinergic receptor P2X 7	Homo sapiens	0-5
30840042-13	2019	Greater MAO-B VT is an index of MAO-B overexpression, which may contribute to pathologies of mitochondrial dysfunction, elevated synthesis of neurotoxic products, and increased metabolism of nonserotonergic monoamines.	monoamines	207-217	monoamine oxidase B	Homo sapiens	8-13
30840042-13	2019	Greater MAO-B VT is an index of MAO-B overexpression, which may contribute to pathologies of mitochondrial dysfunction, elevated synthesis of neurotoxic products, and increased metabolism of nonserotonergic monoamines.	monoamines	207-217	monoamine oxidase B	Homo sapiens	32-37
30610839-1	2019	Mephedrone (4-methyl-N-methylcathinone) is a psychostimulant that promotes release of monoamines via the high affinity transporters for dopamine (DAT), norepinephrine (NET) and serotonin (SERT).	monoamines	86-96	solute carrier family 6 member 3	Homo sapiens	146-149
30610839-1	2019	Mephedrone (4-methyl-N-methylcathinone) is a psychostimulant that promotes release of monoamines via the high affinity transporters for dopamine (DAT), norepinephrine (NET) and serotonin (SERT).	monoamines	86-96	solute carrier family 6 member 4	Homo sapiens	188-192
31240161-1	2019	Background: Brain monoamine vesicular transport disease is an infantile onset neurodevelopmental disorder caused by variants in SLC18A2, which codes for the vesicular monoamine transporter 2 (VMAT2) protein, involved in the transport of monoamines into synaptic vesicles and of serotonin into platelet dense granules.	monoamines	237-247	solute carrier family 18 member A2	Homo sapiens	157-190
31240161-1	2019	Background: Brain monoamine vesicular transport disease is an infantile onset neurodevelopmental disorder caused by variants in SLC18A2, which codes for the vesicular monoamine transporter 2 (VMAT2) protein, involved in the transport of monoamines into synaptic vesicles and of serotonin into platelet dense granules.	monoamines	237-247	solute carrier family 18 member A2	Homo sapiens	192-197
30738894-1	2019	Monoamine oxidase B (MAO-B), a flavoenzyme located in the outer mitochondrial membrane, is involved in the catabolism of monoamines.	monoamines	121-131	monoamine oxidase B	Homo sapiens	0-19
30738894-1	2019	Monoamine oxidase B (MAO-B), a flavoenzyme located in the outer mitochondrial membrane, is involved in the catabolism of monoamines.	monoamines	121-131	monoamine oxidase B	Homo sapiens	21-26
30248432-11	2019	OCT3 likewise appears to be a mechanism through which mephedrone can induce release of monoamines, thereby accounting for the paradoxically more potent psychostimulant effects of MDPV taken together with mephedrone, and greater risk for deleterious side effects.	monoamines	87-97	OCTN3	Homo sapiens	0-4
30312638-0	2019	Novel antagonists of 5-HT6 and/or 5-HT7 receptors affect the brain monoamines metabolism and enhance the anti-immobility activity of different antidepressants in rats.	monoamines	67-77	5-hydroxytryptamine receptor 6	Rattus norvegicus	21-26
30312638-0	2019	Novel antagonists of 5-HT6 and/or 5-HT7 receptors affect the brain monoamines metabolism and enhance the anti-immobility activity of different antidepressants in rats.	monoamines	67-77	basigin (Ok blood group)	Rattus norvegicus	36-39
30198706-2	2019	One of these is the vesicular monoamine transporter 2 (VMAT2), the protein responsible for the energy-dependent accumulation of monoamines into synaptic vesicles.	monoamines	128-138	solute carrier family 18 member A2	Homo sapiens	20-53
30774343-3	2019	During early cigarette withdrawal there is an elevation in the levels of monoamine oxidase-A (MAO-A), which removes monoamines excessively and induces oxidative stress and is implicated in creating sad mood.	monoamines	116-126	monoamine oxidase A	Homo sapiens	73-92
30774343-3	2019	During early cigarette withdrawal there is an elevation in the levels of monoamine oxidase-A (MAO-A), which removes monoamines excessively and induces oxidative stress and is implicated in creating sad mood.	monoamines	116-126	monoamine oxidase A	Homo sapiens	94-99
30198706-2	2019	One of these is the vesicular monoamine transporter 2 (VMAT2), the protein responsible for the energy-dependent accumulation of monoamines into synaptic vesicles.	monoamines	128-138	solute carrier family 18 member A2	Homo sapiens	55-60
29748627-1	2018	Negative emotional states that are associated with excessive alcohol intake, particularly anxiety-like states, have been linked to opponent processes in the central nucleus of the amygdala (CeA), affecting stress-related transmitters and monoamines.	monoamines	238-248	carcinoembryonic antigen gene family 4	Rattus norvegicus	190-193
30473490-1	2019	Growing evidence supports involvement of low-affinity/high-capacity organic cation transporters (OCTs) and plasma membrane monoamine transporter (PMAT) in regulating clearance of monoamines.	monoamines	179-189	solute carrier family 29 (nucleoside transporters), member 4	Mus musculus	107-144
30473490-1	2019	Growing evidence supports involvement of low-affinity/high-capacity organic cation transporters (OCTs) and plasma membrane monoamine transporter (PMAT) in regulating clearance of monoamines.	monoamines	179-189	solute carrier family 29 (nucleoside transporters), member 4	Mus musculus	146-150
30551424-4	2019	Therefore, this study investigates the effects of CPE on a chronic rat model of depression and explores its underlying mechanism of action on neuroinflammation and brain monoamines.	monoamines	170-180	carboxypeptidase E	Rattus norvegicus	50-53
30242487-2	2018	The monoamine oxidases A and B (MAOA/MAOB) are prime candidates for the investigation into the role of DNA methylation in mental disorders, given their pivotal role in the metabolism of monoamines and as pharmacological targets of potent antidepressant drugs such as tranylcypromine, phenelzine or moclobemide.	monoamines	186-196	monoamine oxidase A	Homo sapiens	32-36
30242487-2	2018	The monoamine oxidases A and B (MAOA/MAOB) are prime candidates for the investigation into the role of DNA methylation in mental disorders, given their pivotal role in the metabolism of monoamines and as pharmacological targets of potent antidepressant drugs such as tranylcypromine, phenelzine or moclobemide.	monoamines	186-196	monoamine oxidase B	Homo sapiens	37-41
30447392-1	2019	Extracellular levels of dopamine (DA) and other monoamines in the brain depend not only on the classic transporters encoded by SLC6A gene family such as DAT, NET and SERT, but also a more recently identified group of low-affinity/high-capacity "Uptake-2" transporters, mainly OCT3 and PMAT.	monoamines	48-58	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	166-170
30447392-1	2019	Extracellular levels of dopamine (DA) and other monoamines in the brain depend not only on the classic transporters encoded by SLC6A gene family such as DAT, NET and SERT, but also a more recently identified group of low-affinity/high-capacity "Uptake-2" transporters, mainly OCT3 and PMAT.	monoamines	48-58	solute carrier family 22 (organic cation transporter), member 3	Mus musculus	276-280
30447392-1	2019	Extracellular levels of dopamine (DA) and other monoamines in the brain depend not only on the classic transporters encoded by SLC6A gene family such as DAT, NET and SERT, but also a more recently identified group of low-affinity/high-capacity "Uptake-2" transporters, mainly OCT3 and PMAT.	monoamines	48-58	solute carrier family 29 (nucleoside transporters), member 4	Mus musculus	285-289
30558545-3	2018	A prenatal transient excess of "monoamine oxidase A" enzyme is assumed here to trigger persistent epigenetic regulations that would induce imbalanced metabolisms of synaptic monoamines.	monoamines	174-184	monoamine oxidase A	Homo sapiens	32-51
29754167-7	2018	The possible involvement of monoamines in the effects of SNE was assessed in the TST by pre-treating mice with alpha-methyldopa, reserpine and para-chlorophenylalanine (pCPA) in separate experiments.	monoamines	28-38	thiosulfate sulfurtransferase, mitochondrial	Mus musculus	81-84
27836462-3	2018	Clock genes can regulate the transcription of monoamine oxidase A, which is involved in the degradation of monoamines.	monoamines	107-117	monoamine oxidase A	Homo sapiens	46-65
29636691-3	2018	Evidence from electrophysiological and neurochemical studies evaluating the effects of genetic and pharmacological interventions on TAAR1 revealed that TAAR1 modulates transmission of monoamines, especially dopamine.	monoamines	184-194	trace amine associated receptor 1	Homo sapiens	132-137
28540658-7	2018	These results suggest that DYRK1A overexpression might be associated with the modification of monoamines content found in individuals with T21 and reinforce the interest to target the level of DYRK1A expression as a therapeutic approach for persons with T21.	monoamines	94-104	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	27-33
29483339-4	2018	This strategy will enable specific functions of monoamines and other neuromodulators such as acetylcholine and neuropeptides (such as orexin) to be defined with respect to their roles in modulating activity in specific neural networks-leading to a more realistic definition of their interactive roles in complex, biologically based traits (i.e. temperament).This article is part of the theme issue "Diverse perspectives on diversity: multi-disciplinary approaches to taxonomies of individual differences".	monoamines	48-58	hypocretin neuropeptide precursor	Homo sapiens	134-140
29915137-7	2018	Electrophysiological experiments found that GABAergic neurons in the VLPO (GABAVLPO neurons) that make direct input to orexin or histaminergic neurons are potently inhibited by noradrenaline and serotonin, suggesting that these monoamines disinhibit histamine and orexin neurons.	monoamines	228-238	hypocretin neuropeptide precursor	Homo sapiens	119-125
29915137-7	2018	Electrophysiological experiments found that GABAergic neurons in the VLPO (GABAVLPO neurons) that make direct input to orexin or histaminergic neurons are potently inhibited by noradrenaline and serotonin, suggesting that these monoamines disinhibit histamine and orexin neurons.	monoamines	228-238	hypocretin neuropeptide precursor	Homo sapiens	264-270
29549852-2	2018	Monoamine oxidase A (MAO-A) is an important enzyme that metabolizes monoamines and creates oxidative stress.	monoamines	68-78	monoamine oxidase A	Homo sapiens	0-19
29549852-2	2018	Monoamine oxidase A (MAO-A) is an important enzyme that metabolizes monoamines and creates oxidative stress.	monoamines	68-78	monoamine oxidase A	Homo sapiens	21-26
29796223-0	2018	The effect of intracerebroventricular injection of CGRP on pain behavioral responses and monoamines concentrations in the periaqueductal gray area in rat.	monoamines	89-99	calcitonin-related polypeptide alpha	Rattus norvegicus	51-55
29796223-10	2018	Conclusion: CGRP significantly reduced pain by increased concentrations of monoamines and their metabolites in dialysates from PAG when injected ICV to rats.	monoamines	75-85	calcitonin-related polypeptide alpha	Rattus norvegicus	12-16
29636691-3	2018	Evidence from electrophysiological and neurochemical studies evaluating the effects of genetic and pharmacological interventions on TAAR1 revealed that TAAR1 modulates transmission of monoamines, especially dopamine.	monoamines	184-194	trace amine associated receptor 1	Homo sapiens	152-157
29577193-2	2018	The increase in the level of immune subunits LMP2 and LMP7 was more pronounced in the liver of August rats in comparison with Wistar rats (by 2 and 6 times, respectively), which was associated with higher concentrations of monoamines in the CNS of August rats.	monoamines	223-233	proteasome 20S subunit beta 9	Rattus norvegicus	45-49
29552556-1	2018	Monoamine oxidase B (MAO-B) catalyzes deamination of monoamines such as neurotransmitters dopamine and norepinephrine.	monoamines	53-63	monoamine oxidase B	Homo sapiens	0-19
29552556-1	2018	Monoamine oxidase B (MAO-B) catalyzes deamination of monoamines such as neurotransmitters dopamine and norepinephrine.	monoamines	53-63	monoamine oxidase B	Homo sapiens	21-26
29577193-2	2018	The increase in the level of immune subunits LMP2 and LMP7 was more pronounced in the liver of August rats in comparison with Wistar rats (by 2 and 6 times, respectively), which was associated with higher concentrations of monoamines in the CNS of August rats.	monoamines	223-233	proteasome 20S subunit beta 8	Rattus norvegicus	54-58
27913432-6	2018	Although VMAT2 is known to package monoamines into synaptic vesicles, in VENs and fork cells its expression occurs in the absence of monoamine-synthesizing enzymes or reuptake transporters.	monoamines	35-45	solute carrier family 18 member A2	Homo sapiens	9-14
32440083-8	2017	The primary monoamines, methylamine, ethylamine and n-propylamine constitute the most abundant amines in the CO3, CV3, CK4, and CK5 meteorites studied here.	monoamines	12-22	keratin 4	Homo sapiens	119-122
29680151-5	2018	The vesicular monoamine transporter 2 (VMAT2) is an integral presynaptic protein that regulates the packaging and subsequent release of dopamine and other monoamines from neuronal vesicles into the synapse.	monoamines	155-165	solute carrier family 18 member A2	Homo sapiens	4-37
29680151-5	2018	The vesicular monoamine transporter 2 (VMAT2) is an integral presynaptic protein that regulates the packaging and subsequent release of dopamine and other monoamines from neuronal vesicles into the synapse.	monoamines	155-165	solute carrier family 18 member A2	Homo sapiens	39-44
29587269-7	2018	These results provide the first evidence that STAT6 affects depressive-like behavior through downregulating monoamines, including dopamine and 5-HT in the hippocampus of brain.	monoamines	108-118	signal transducer and activator of transcription 6	Mus musculus	46-51
32440083-8	2017	The primary monoamines, methylamine, ethylamine and n-propylamine constitute the most abundant amines in the CO3, CV3, CK4, and CK5 meteorites studied here.	monoamines	12-22	keratin 5	Homo sapiens	128-131
29063330-0	2017	Effects of Oxytocin on the Levels and Metabolism of Monoamines in the Brain of White Outbred Mice during Long-Term Social Isolation.	monoamines	52-62	oxytocin	Mus musculus	11-19
28627776-1	2017	The antidepressant venlafaxine is known to increase the turnover of cerebral monoamines, which are catabolized by the catechol-O-methyltransferase (COMT).	monoamines	77-87	catechol-O-methyltransferase	Homo sapiens	118-146
28627776-1	2017	The antidepressant venlafaxine is known to increase the turnover of cerebral monoamines, which are catabolized by the catechol-O-methyltransferase (COMT).	monoamines	77-87	catechol-O-methyltransferase	Homo sapiens	148-152
29063330-1	2017	The effects of intranasal administration of oxytocin on the levels and metabolism of monoamines in symmetrical structures of the brain of white outbred mice kept under conditions of long-term social isolation were studied by HPLC.	monoamines	85-95	oxytocin	Mus musculus	44-52
28963508-1	2017	The type 2 vesicular monoamine transporter (VMAT2), by regulating the storage of monoamines transmitters into synaptic vesicles, has a protective role against their cytoplasmic toxicity.	monoamines	81-91	solute carrier family 18 (vesicular monoamine), member 2	Mus musculus	44-49
29033796-9	2017	This complex distribution suggests that monoamines may modulate the communications between PFC and cortical/subcortical areas through the activation of receptors expressed by neurons in intermediate (e.g., 5-HT1A, 5-HT2A, alpha1D-adrenoceptors, dopamine D1 receptors) and deep layers (e.g., 5-HT1A, 5-HT2A, alpha1A-adrenoceptors, dopamine D2 receptors), respectively.	monoamines	40-50	5-hydroxytryptamine receptor 1A	Rattus norvegicus	206-212
29033796-9	2017	This complex distribution suggests that monoamines may modulate the communications between PFC and cortical/subcortical areas through the activation of receptors expressed by neurons in intermediate (e.g., 5-HT1A, 5-HT2A, alpha1D-adrenoceptors, dopamine D1 receptors) and deep layers (e.g., 5-HT1A, 5-HT2A, alpha1A-adrenoceptors, dopamine D2 receptors), respectively.	monoamines	40-50	5-hydroxytryptamine receptor 2A	Rattus norvegicus	214-220
29033796-9	2017	This complex distribution suggests that monoamines may modulate the communications between PFC and cortical/subcortical areas through the activation of receptors expressed by neurons in intermediate (e.g., 5-HT1A, 5-HT2A, alpha1D-adrenoceptors, dopamine D1 receptors) and deep layers (e.g., 5-HT1A, 5-HT2A, alpha1A-adrenoceptors, dopamine D2 receptors), respectively.	monoamines	40-50	5-hydroxytryptamine receptor 1A	Rattus norvegicus	291-297
29033796-9	2017	This complex distribution suggests that monoamines may modulate the communications between PFC and cortical/subcortical areas through the activation of receptors expressed by neurons in intermediate (e.g., 5-HT1A, 5-HT2A, alpha1D-adrenoceptors, dopamine D1 receptors) and deep layers (e.g., 5-HT1A, 5-HT2A, alpha1A-adrenoceptors, dopamine D2 receptors), respectively.	monoamines	40-50	5-hydroxytryptamine receptor 2A	Rattus norvegicus	299-305
28476685-3	2017	Vesicular monoamine transporter 1 (VMAT1/SLC18A1) is an attractive candidate gene for psychiatric disorders because of its participation in regulation monoamines.	monoamines	151-161	solute carrier family 18 member A1	Homo sapiens	0-33
28476685-3	2017	Vesicular monoamine transporter 1 (VMAT1/SLC18A1) is an attractive candidate gene for psychiatric disorders because of its participation in regulation monoamines.	monoamines	151-161	solute carrier family 18 member A1	Homo sapiens	35-40
28476685-3	2017	Vesicular monoamine transporter 1 (VMAT1/SLC18A1) is an attractive candidate gene for psychiatric disorders because of its participation in regulation monoamines.	monoamines	151-161	solute carrier family 18 member A1	Homo sapiens	41-48
28476685-11	2017	Considering the role of VMAT1 in regulation of monoamines, the dysregulated expression of this protein during early stages of brain development might be implicated in ASD.	monoamines	47-57	solute carrier family 18 member A1	Homo sapiens	24-29
28596586-1	2017	Monoaminergic neurotransmission is greatly dependent on the function of the vesicular monoamine transporter VMAT2, which is responsible for loading monoamines into secretory vesicles.	monoamines	148-158	solute carrier family 18 member 2	Danio rerio	108-113
28336394-3	2017	Here, we conducted comprehensive behavioral analyses, including anxiety-, sociability-, and depression-related tasks, and biochemical analyses of monoamines and their metabolites in Ts1Cje mice.	monoamines	146-156	reciprocal translocation, Chr 12 and 16, Epstein 1	Mus musculus	182-188
27659446-1	2017	Organic cation transporter 3 (OCT3) is a high-capacity, low-affinity transporter that mediates corticosterone-sensitive uptake of monoamines including norepinephrine, epinephrine, dopamine, histamine and serotonin.	monoamines	130-140	solute carrier family 22 member 3	Rattus norvegicus	0-28
28726205-1	2017	The levels of monoamines and their metabolites in brain structures of adult (3-month-old) rats with emotional and motivational disorders induced by inhibitors of dipeptidyl peptidase 4 (DPP-4; EC 3.4.14.5) diprotin A and sitagliptin on weeks 2-3 of postnatal development (postnatal days 5-18) were studied by HPLC with electrochemical detection.	monoamines	14-24	dipeptidylpeptidase 4	Rattus norvegicus	186-191
28404690-1	2017	The vesicular monoamine transporter 2 (VMAT2) is an integral presynaptic protein that regulates the packaging and subsequent release of dopamine and other monoamines from neuronal vesicles into the synapse.	monoamines	155-165	solute carrier family 18 member A2	Rattus norvegicus	4-37
28404690-1	2017	The vesicular monoamine transporter 2 (VMAT2) is an integral presynaptic protein that regulates the packaging and subsequent release of dopamine and other monoamines from neuronal vesicles into the synapse.	monoamines	155-165	solute carrier family 18 member A2	Rattus norvegicus	39-44
27659446-1	2017	Organic cation transporter 3 (OCT3) is a high-capacity, low-affinity transporter that mediates corticosterone-sensitive uptake of monoamines including norepinephrine, epinephrine, dopamine, histamine and serotonin.	monoamines	130-140	solute carrier family 22 member 3	Rattus norvegicus	30-34
27659446-2	2017	OCT3 is expressed widely throughout the amygdaloid complex and other brain regions where monoamines are key regulators of emotional behaviors affected by stress.	monoamines	89-99	solute carrier family 22 member 3	Rattus norvegicus	0-4
27659446-9	2017	The localization of OCT3 to neuronal and glial plasma membranes adjacent to synaptic sites is consistent with an important role for this transporter in regulating the amplitude, duration, and physical spread of released monoamines, while its localization to mitochondrial and outer nuclear membranes suggests previously undescribed roles for the transporter in the intracellular disposition of monoamines.	monoamines	220-230	solute carrier family 22 member 3	Rattus norvegicus	20-24
27659446-9	2017	The localization of OCT3 to neuronal and glial plasma membranes adjacent to synaptic sites is consistent with an important role for this transporter in regulating the amplitude, duration, and physical spread of released monoamines, while its localization to mitochondrial and outer nuclear membranes suggests previously undescribed roles for the transporter in the intracellular disposition of monoamines.	monoamines	394-404	solute carrier family 22 member 3	Rattus norvegicus	20-24
27989747-2	2017	Monoamines are metabolized through oxidative deamination catalyzed by the mitochondrial enzyme monoamine oxidase (MAO).	monoamines	0-10	monoamine oxidase A	Rattus norvegicus	95-112
27979380-0	2017	Central administration of neuropeptide Y differentially regulates monoamines and corticosterone in heat-exposed fed and fasted chicks.	monoamines	66-76	neuropeptide Y	Homo sapiens	26-40
27979380-11	2017	In conclusion, brain NPY may attenuate the reduction of food intake during heat stress and the increased brain NPY might be a potential regulator of the monoamines and corticosterone to modulate stress response in heat-exposed chicks.	monoamines	153-163	neuropeptide Y	Homo sapiens	111-114
27973928-2	2017	The aromatic amino acid hydroxylases tyrosine hydroxylase (TH), tryptophan hydroxylase 1 (TPH1), and tryptophan hydroxylase 2 (TPH2) catalyse the rate-limiting steps in the biosynthesis of these monoamines.	monoamines	195-205	tyrosine hydroxylase	Homo sapiens	37-57
27973928-2	2017	The aromatic amino acid hydroxylases tyrosine hydroxylase (TH), tryptophan hydroxylase 1 (TPH1), and tryptophan hydroxylase 2 (TPH2) catalyse the rate-limiting steps in the biosynthesis of these monoamines.	monoamines	195-205	tyrosine hydroxylase	Homo sapiens	59-61
27973928-2	2017	The aromatic amino acid hydroxylases tyrosine hydroxylase (TH), tryptophan hydroxylase 1 (TPH1), and tryptophan hydroxylase 2 (TPH2) catalyse the rate-limiting steps in the biosynthesis of these monoamines.	monoamines	195-205	tryptophan hydroxylase 1	Homo sapiens	64-88
27973928-2	2017	The aromatic amino acid hydroxylases tyrosine hydroxylase (TH), tryptophan hydroxylase 1 (TPH1), and tryptophan hydroxylase 2 (TPH2) catalyse the rate-limiting steps in the biosynthesis of these monoamines.	monoamines	195-205	tryptophan hydroxylase 1	Homo sapiens	90-94
27973928-2	2017	The aromatic amino acid hydroxylases tyrosine hydroxylase (TH), tryptophan hydroxylase 1 (TPH1), and tryptophan hydroxylase 2 (TPH2) catalyse the rate-limiting steps in the biosynthesis of these monoamines.	monoamines	195-205	tryptophan hydroxylase 2	Homo sapiens	101-125
27973928-2	2017	The aromatic amino acid hydroxylases tyrosine hydroxylase (TH), tryptophan hydroxylase 1 (TPH1), and tryptophan hydroxylase 2 (TPH2) catalyse the rate-limiting steps in the biosynthesis of these monoamines.	monoamines	195-205	tryptophan hydroxylase 2	Homo sapiens	127-131
27989747-2	2017	Monoamines are metabolized through oxidative deamination catalyzed by the mitochondrial enzyme monoamine oxidase (MAO).	monoamines	0-10	monoamine oxidase A	Rattus norvegicus	114-117
27901065-1	2016	p-Tyramine is an archetypal member of the endogenous family of monoamines known as trace amines, and is one of the endogenous agonists for trace amine-associated receptor (TAAR)1.	monoamines	63-73	trace-amine-associated receptor 1	Rattus norvegicus	172-178
27693848-5	2017	We measured contents of TRP and monoamines and their metabolites in the serum and hippocampus of KMO KO mice.	monoamines	32-42	kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)	Mus musculus	97-100
27651065-8	2016	Together, our results demonstrated that the polyspecific cation transporter OCT2 is distributed in cholinergic and monoaminergic terminals in various forebrain regions, suggesting that OCT2 could play a role in regulating presynaptic reuptake and recycling of choline and monoamines.	monoamines	272-282	solute carrier family 22 (organic cation transporter), member 2	Mus musculus	76-80
27651065-8	2016	Together, our results demonstrated that the polyspecific cation transporter OCT2 is distributed in cholinergic and monoaminergic terminals in various forebrain regions, suggesting that OCT2 could play a role in regulating presynaptic reuptake and recycling of choline and monoamines.	monoamines	272-282	solute carrier family 22 (organic cation transporter), member 2	Mus musculus	185-189
27720849-12	2016	The observed effect is probably due to multiple underlying mechanisms including its modulating effect on acetylcholine levels in the brain and MAO-inhibitory activity leading to stimulation of the monoamines" neurotransmission.	monoamines	197-207	monoamine oxidase A	Rattus norvegicus	143-146
27575476-1	2016	Monoamine oxidase (MAO) catalyzes the oxidation of monoamines and its two isoforms, MAO-A and MAO-B, break down neurotransmitter amines.	monoamines	51-61	monoamine oxidase B	Homo sapiens	94-99
27142678-8	2016	The predicted function of RBFOX3 based on co-expression analysis with other genes shows that this gene is significantly involved in the release cycle of neurotransmitters including gamma-aminobutyric acid and various monoamines (P-values<2.9 x 10(-11)) that are crucial in triggering the onset of sleep.	monoamines	217-227	RNA binding fox-1 homolog 3	Homo sapiens	26-32
26876819-3	2016	Recently, a functional variant in the presynaptic vesicular monoamine transporter gene (VMAT1/SLC18A1-Thr136Ile-rs1390938) was found to significantly increase transport of monoamines into synaptic vesicles in vitro.	monoamines	172-182	solute carrier family 18 member A1	Homo sapiens	88-93
26996926-5	2016	In this study, we utilized in vivo microdialysis in live, behaving rats to assess the effect of the PKCbeta inhibitors, enzastaurin and ruboxistaurin, on amphetamine-stimulated locomotion and increases in monoamines and their metabolites.	monoamines	205-215	protein kinase C, beta	Rattus norvegicus	100-107
27341797-3	2016	Monoamine oxidase A (MAOA) and B (MAOB), two isoenzymes bound to the outer membrane of mitochondria, are involved in the degradation of monoamines and were explored for association with ADHD in different ethnic groups.	monoamines	136-146	monoamine oxidase A	Homo sapiens	0-19
27341797-3	2016	Monoamine oxidase A (MAOA) and B (MAOB), two isoenzymes bound to the outer membrane of mitochondria, are involved in the degradation of monoamines and were explored for association with ADHD in different ethnic groups.	monoamines	136-146	monoamine oxidase A	Homo sapiens	21-25
27341797-3	2016	Monoamine oxidase A (MAOA) and B (MAOB), two isoenzymes bound to the outer membrane of mitochondria, are involved in the degradation of monoamines and were explored for association with ADHD in different ethnic groups.	monoamines	136-146	monoamine oxidase B	Homo sapiens	34-38
26876819-3	2016	Recently, a functional variant in the presynaptic vesicular monoamine transporter gene (VMAT1/SLC18A1-Thr136Ile-rs1390938) was found to significantly increase transport of monoamines into synaptic vesicles in vitro.	monoamines	172-182	solute carrier family 18 member A1	Homo sapiens	94-101
26503837-2	2015	There is also growing evidence that all three monoamines are taken up into neurons by low-affinity, high-capacity organic cation transporters (OCT) and the plasma membrane monoamine transporter (PMAT).	monoamines	46-56	solute carrier family 29 (nucleoside transporters), member 4	Mus musculus	156-193
26561069-2	2016	1.4.3.4) is a flavin-adenine type of enzyme with two isoforms referred to MAO-A and MAO-B that function for oxidation of monoamines.	monoamines	121-131	monoamine oxidase A	Homo sapiens	74-79
26561069-2	2016	1.4.3.4) is a flavin-adenine type of enzyme with two isoforms referred to MAO-A and MAO-B that function for oxidation of monoamines.	monoamines	121-131	monoamine oxidase B	Homo sapiens	84-89
26541750-3	2015	In the central nervous system, vesicular monoamine transporter 2 (VMAT2) is responsible for the uptake of monoamines, vesicular acetylcholine transporter (VAChT) is responsible for the uptake of acetylcholine, while vesicular glutamate transporters 1 and 2 (VGLUT1 and VGLUT2) are responsible for the uptake of glutamate.	monoamines	106-116	solute carrier family 18 member A2	Homo sapiens	31-64
26503837-2	2015	There is also growing evidence that all three monoamines are taken up into neurons by low-affinity, high-capacity organic cation transporters (OCT) and the plasma membrane monoamine transporter (PMAT).	monoamines	46-56	solute carrier family 29 (nucleoside transporters), member 4	Mus musculus	195-199
26541750-3	2015	In the central nervous system, vesicular monoamine transporter 2 (VMAT2) is responsible for the uptake of monoamines, vesicular acetylcholine transporter (VAChT) is responsible for the uptake of acetylcholine, while vesicular glutamate transporters 1 and 2 (VGLUT1 and VGLUT2) are responsible for the uptake of glutamate.	monoamines	106-116	solute carrier family 18 member A2	Homo sapiens	66-71
26110222-8	2015	Monoamines were measured by HPLC: Fmr1 KO mice showed an increase in the striatal dopamine level.	monoamines	0-10	fragile X messenger ribonucleoprotein 1	Mus musculus	34-38
26541750-3	2015	In the central nervous system, vesicular monoamine transporter 2 (VMAT2) is responsible for the uptake of monoamines, vesicular acetylcholine transporter (VAChT) is responsible for the uptake of acetylcholine, while vesicular glutamate transporters 1 and 2 (VGLUT1 and VGLUT2) are responsible for the uptake of glutamate.	monoamines	106-116	solute carrier family 18 member A3	Homo sapiens	118-153
26541750-3	2015	In the central nervous system, vesicular monoamine transporter 2 (VMAT2) is responsible for the uptake of monoamines, vesicular acetylcholine transporter (VAChT) is responsible for the uptake of acetylcholine, while vesicular glutamate transporters 1 and 2 (VGLUT1 and VGLUT2) are responsible for the uptake of glutamate.	monoamines	106-116	solute carrier family 18 member A3	Homo sapiens	155-160
26541750-3	2015	In the central nervous system, vesicular monoamine transporter 2 (VMAT2) is responsible for the uptake of monoamines, vesicular acetylcholine transporter (VAChT) is responsible for the uptake of acetylcholine, while vesicular glutamate transporters 1 and 2 (VGLUT1 and VGLUT2) are responsible for the uptake of glutamate.	monoamines	106-116	solute carrier family 17 member 7	Homo sapiens	216-256
26541750-3	2015	In the central nervous system, vesicular monoamine transporter 2 (VMAT2) is responsible for the uptake of monoamines, vesicular acetylcholine transporter (VAChT) is responsible for the uptake of acetylcholine, while vesicular glutamate transporters 1 and 2 (VGLUT1 and VGLUT2) are responsible for the uptake of glutamate.	monoamines	106-116	solute carrier family 17 member 7	Homo sapiens	258-264
26541750-3	2015	In the central nervous system, vesicular monoamine transporter 2 (VMAT2) is responsible for the uptake of monoamines, vesicular acetylcholine transporter (VAChT) is responsible for the uptake of acetylcholine, while vesicular glutamate transporters 1 and 2 (VGLUT1 and VGLUT2) are responsible for the uptake of glutamate.	monoamines	106-116	solute carrier family 17 member 6	Homo sapiens	269-275
26361739-5	2015	Next, we measured the levels of monoamines and their metabolites in the adult mouse brain and found that the activities of monoaminergic systems were altered in Shati(-/-) mice.	monoamines	32-42	N-acetyltransferase 8-like	Mus musculus	161-166
26352512-10	2015	Furthermore, our findings substantiate the potential function of ChgA as a monoamine-binding protein that facilitates the regulated endocrine secretion of large amounts of monoamines from enteroendocrine cells.	monoamines	172-182	chromogranin A	Mus musculus	65-69
26152722-1	2015	We sought to examine interactions of the prion protein (PrP(C)) with monoaminergic systems due to: the role of PrP(C) in both Prion and Alzheimer diseases, which include clinical depression among their symptoms, the implication of monoamines in depression, and the hypothesis that PrP(C) serves as a scaffold for signaling systems.	monoamines	231-241	prion protein	Mus musculus	56-62
26285061-5	2015	In anticipation and reaction to aggressive behavior, neuropeptides such as corticotropin-releasing factor, neuropeptide Y, opioid peptides, and vasopressin interact with monoamines, GABA, and glutamate to attenuate and amplify aggressive behavior in alcohol-consuming individuals.	monoamines	170-180	neuropeptide Y	Homo sapiens	107-121
26285061-5	2015	In anticipation and reaction to aggressive behavior, neuropeptides such as corticotropin-releasing factor, neuropeptide Y, opioid peptides, and vasopressin interact with monoamines, GABA, and glutamate to attenuate and amplify aggressive behavior in alcohol-consuming individuals.	monoamines	170-180	arginine vasopressin	Homo sapiens	144-155
25873594-1	2015	The membrane transporters for the monoamines serotonin (SERT) and dopamine (DAT) are prominent targets of various psychoactive substances, including competitive inhibitors, such as tricyclic antidepressants, methylphenidate, and cocaine.	monoamines	34-44	solute carrier family 6 member 4	Homo sapiens	45-54
25873594-1	2015	The membrane transporters for the monoamines serotonin (SERT) and dopamine (DAT) are prominent targets of various psychoactive substances, including competitive inhibitors, such as tricyclic antidepressants, methylphenidate, and cocaine.	monoamines	34-44	solute carrier family 6 member 4	Homo sapiens	56-60
25873594-1	2015	The membrane transporters for the monoamines serotonin (SERT) and dopamine (DAT) are prominent targets of various psychoactive substances, including competitive inhibitors, such as tricyclic antidepressants, methylphenidate, and cocaine.	monoamines	34-44	solute carrier family 6 member 3	Homo sapiens	76-79
25218873-0	2014	Putative role of monoamines in the antidepressant-like mechanism induced by striatal MT2 blockade.	monoamines	17-27	metallothionein 2A	Rattus norvegicus	85-88
25597272-1	2015	The organic cation transporter-3 (OCT3) is a glucocorticoid-sensitive uptake mechanism that has been shown to regulate the bioavailability of monoamines in brain regions that are implicated in the pathophysiology of depression.	monoamines	142-152	solute carrier family 22 member 3	Rattus norvegicus	4-32
25597272-1	2015	The organic cation transporter-3 (OCT3) is a glucocorticoid-sensitive uptake mechanism that has been shown to regulate the bioavailability of monoamines in brain regions that are implicated in the pathophysiology of depression.	monoamines	142-152	solute carrier family 22 member 3	Rattus norvegicus	34-38
25978392-2	2015	MAO, catalyzing the reaction of oxidative deamination of major neurotransmitter monoamines, exists in two highly homologous forms, MAO A and MAO B, distinguished by substrate specificity and inhibitor selectivity.	monoamines	80-90	monoamine oxidase A	Homo sapiens	131-136
25978392-2	2015	MAO, catalyzing the reaction of oxidative deamination of major neurotransmitter monoamines, exists in two highly homologous forms, MAO A and MAO B, distinguished by substrate specificity and inhibitor selectivity.	monoamines	80-90	monoamine oxidase B	Homo sapiens	141-146
25585152-2	2015	Monoamine oxidase A (MAOA), a mitochondria-bound enzyme, degrades monoamine neurotransmitters and dietary monoamines.	monoamines	106-116	monoamine oxidase A	Homo sapiens	0-19
25585152-2	2015	Monoamine oxidase A (MAOA), a mitochondria-bound enzyme, degrades monoamine neurotransmitters and dietary monoamines.	monoamines	106-116	monoamine oxidase A	Homo sapiens	21-25
25286119-4	2015	Acute depletion of monoamines with reserpine, but not with AMPT or PCPA, reduced FADD (28%) and increased p-FADD/FADD ratio (1.34-fold).	monoamines	19-29	Fas associated via death domain	Rattus norvegicus	81-85
25286119-4	2015	Acute depletion of monoamines with reserpine, but not with AMPT or PCPA, reduced FADD (28%) and increased p-FADD/FADD ratio (1.34-fold).	monoamines	19-29	Fas associated via death domain	Rattus norvegicus	108-112
25286119-4	2015	Acute depletion of monoamines with reserpine, but not with AMPT or PCPA, reduced FADD (28%) and increased p-FADD/FADD ratio (1.34-fold).	monoamines	19-29	Fas associated via death domain	Rattus norvegicus	108-112
25817861-3	2015	Therefore, in this study, we attempted to evaluate the possible role of the PCLO SNP in the mechanisms of uptake of monoamines.	monoamines	116-126	piccolo presynaptic cytomatrix protein	Homo sapiens	76-80
24898155-3	2014	Monoamine oxidase A (MAO-A) is an important brain enzyme that creates oxidative stress, influences apoptosis, and metabolizes monoamines.	monoamines	126-136	monoamine oxidase A	Homo sapiens	0-19
25186745-0	2014	Spinal cord injury enables aromatic L-amino acid decarboxylase cells to synthesize monoamines.	monoamines	83-93	dopa decarboxylase	Homo sapiens	27-62
25253656-1	2014	The membrane bound enzyme monoamine oxidase exist in two splice variants designated A and B (MAO-A and MAO-B) and are key players in the oxidative metabolism of monoamines in mammalians.	monoamines	161-171	monoamine oxidase A	Homo sapiens	93-98
25253656-1	2014	The membrane bound enzyme monoamine oxidase exist in two splice variants designated A and B (MAO-A and MAO-B) and are key players in the oxidative metabolism of monoamines in mammalians.	monoamines	161-171	monoamine oxidase B	Homo sapiens	103-108
25253656-6	2014	This new insight is important for the understanding of the substrate specificity of the MAO-B enzyme and will be relevant for future drug design within the field of monoamines.	monoamines	165-175	monoamine oxidase B	Homo sapiens	88-93
24898155-3	2014	Monoamine oxidase A (MAO-A) is an important brain enzyme that creates oxidative stress, influences apoptosis, and metabolizes monoamines.	monoamines	126-136	monoamine oxidase A	Homo sapiens	21-26
24525708-6	2014	SLC18A2 is involved in transporting monoamines to synaptic vesicles and has been implicated in a number of neuropsychiatric disorders including major depression.	monoamines	36-46	solute carrier family 18 member A2	Homo sapiens	0-7
24169519-7	2014	This novel missense mutation decreases MAOA enzymatic activity, leading to abnormal levels of urinary monoamines.	monoamines	102-112	monoamine oxidase A	Homo sapiens	39-43
24471494-10	2014	Gene-knockdown assays revealed that 1321N1 and primary human astrocytes could transport monoamines predominantly through PMAT and partly through OCT3.	monoamines	88-98	solute carrier family 29 member 4	Homo sapiens	121-125
24828646-3	2014	To address this issue, we generated mutations in the C-terminal trafficking domain of the Drosophila vesicular monoamine transporter (DVMAT), which is required for the vesicular storage of monoamines in both SVs and LDCVs.	monoamines	189-199	Vesicular monoamine transporter	Drosophila melanogaster	90-132
24828646-3	2014	To address this issue, we generated mutations in the C-terminal trafficking domain of the Drosophila vesicular monoamine transporter (DVMAT), which is required for the vesicular storage of monoamines in both SVs and LDCVs.	monoamines	189-199	Vesicular monoamine transporter	Drosophila melanogaster	134-139
24681257-4	2014	Analysis of Tg8 transgenic mice, invalidated for the monoamine oxidase-A gene and with consequently high levels of brain monoamines and AVP in the SON, showed that free radicals are more abundant in their SON than in that of wild-type mice (WT).	monoamines	121-131	monoamine oxidase A	Mus musculus	53-72
24471494-10	2014	Gene-knockdown assays revealed that 1321N1 and primary human astrocytes could transport monoamines predominantly through PMAT and partly through OCT3.	monoamines	88-98	solute carrier family 22 member 3	Homo sapiens	145-149
24249529-2	2014	Furthermore, we investigated whether the changes in the BCAA/AAA ratio affected the hippocampal concentration of monoamines [serotonin (5-HT), dopamine (DA) and noradrenaline (NA)].	monoamines	113-123	AT-rich interaction domain 4B	Rattus norvegicus	56-60
24251585-1	2014	BACKGROUND AND PURPOSE: Amphetamines bind to the plasmalemmal transporters for the monoamines dopamine (DAT), noradrenaline (NET) and 5-HT (SERT); influx of amphetamine leads to efflux of substrates.	monoamines	83-93	solute carrier family 6 member 3	Homo sapiens	104-107
24154665-8	2014	As MAO-A creates oxidative stress, facilitates apoptosis, and metabolizes monoamines, therapeutics opposing these processes are predicted to best treat MDE with greater severity and reversed neurovegetative symptoms.	monoamines	74-84	monoamine oxidase A	Homo sapiens	3-8
24453523-1	2014	Aromatic L-amino acid decarboxylase (AADC) deficiency (MIM #608643) is an autosomal recessive inborn error of monoamines.	monoamines	110-120	dopa decarboxylase	Homo sapiens	0-35
24316738-4	2014	VMAT2-controlled monoamines, such as dopamine, histamine and serotonin, negatively regulated beta-cell differentiation.	monoamines	17-27	solute carrier family 18 (vesicular monoamine), member 2	Mus musculus	0-5
24321736-9	2014	The disturbed activity of PLP dependent enzymes apparently forms those profound disturbances of neurotransmitter systems, which are inherent in ADHD: low concentrations of monoamines and disordered amino acid metabolism.	monoamines	172-182	pyridoxal phosphatase	Homo sapiens	26-29
24251585-1	2014	BACKGROUND AND PURPOSE: Amphetamines bind to the plasmalemmal transporters for the monoamines dopamine (DAT), noradrenaline (NET) and 5-HT (SERT); influx of amphetamine leads to efflux of substrates.	monoamines	83-93	solute carrier family 6 member 4	Homo sapiens	140-144
24532984-7	2013	Catechol-O-methyltransferase (COMT) and/or monoamine oxidase (MAO) catalyze the metabolism of monoamines.	monoamines	94-104	catechol-O-methyltransferase	Homo sapiens	0-28
24532984-7	2013	Catechol-O-methyltransferase (COMT) and/or monoamine oxidase (MAO) catalyze the metabolism of monoamines.	monoamines	94-104	catechol-O-methyltransferase	Homo sapiens	30-34
24062308-1	2013	Vesicular monoamine transporter 2 (VMAT2) transports monoamines into storage vesicles in a process that involves exchange of the charged monoamine with two protons.	monoamines	53-63	solute carrier family 18 member A2	Homo sapiens	0-33
24062308-1	2013	Vesicular monoamine transporter 2 (VMAT2) transports monoamines into storage vesicles in a process that involves exchange of the charged monoamine with two protons.	monoamines	53-63	solute carrier family 18 member A2	Homo sapiens	35-40
24176021-12	2013	The mechanisms of action of anti-depressive effect of turmerone seemed to involve an increase of the monoamines level decreasing the MAO-A activity and the stress of mice.	monoamines	101-111	monoamine oxidase A	Mus musculus	133-138
24005822-2	2013	Monoamine oxidase B (MAO-B) activity, involved in the oxidation of biogenic monoamines, is particularly high around the senile plaques and increased in AD patients in middle to late clinical stages of the disease.	monoamines	76-86	monoamine oxidase B	Homo sapiens	0-19
23882123-9	2013	In addition, we show that the balance between basal levels of monoamines and of ACh modulates aggressiveness and this modulation requires functional beta2*nAChRs.	monoamines	62-72	hemoglobin, beta adult minor chain	Mus musculus	149-154
24005822-2	2013	Monoamine oxidase B (MAO-B) activity, involved in the oxidation of biogenic monoamines, is particularly high around the senile plaques and increased in AD patients in middle to late clinical stages of the disease.	monoamines	76-86	monoamine oxidase B	Homo sapiens	21-26
22532702-8	2013	Genetic variation in VMAT2 may be linked to alterations in cognitive functioning underlying psychotic disorder, possibly through altered transport of monoamines into synaptic vesicles.	monoamines	150-160	solute carrier family 18 member A2	Homo sapiens	21-26
23694905-5	2013	We have recently demonstrated the expression of organic cation transporter 3 (OCT3), a high-capacity transporter for dopamine and other monoamines, throughout the rat brain.	monoamines	136-146	solute carrier family 22 member 3	Rattus norvegicus	48-76
23694905-5	2013	We have recently demonstrated the expression of organic cation transporter 3 (OCT3), a high-capacity transporter for dopamine and other monoamines, throughout the rat brain.	monoamines	136-146	solute carrier family 22 member 3	Rattus norvegicus	78-82
23504951-1	2013	In the central nervous system (CNS), vesicular monoamine transporter 2 (VMAT2) transports cytoplasmic monoamines such as dopamine into synaptic vesicles for storage and subsequent exocytotic release.	monoamines	102-112	solute carrier family 18 member A2	Homo sapiens	37-70
24009838-6	2012	Pretreatment with ginsenoside Rb1 attenuated the stress-induced changes in the levels of monoamines in each region.	monoamines	89-99	RB transcriptional corepressor 1	Mus musculus	30-33
23504951-1	2013	In the central nervous system (CNS), vesicular monoamine transporter 2 (VMAT2) transports cytoplasmic monoamines such as dopamine into synaptic vesicles for storage and subsequent exocytotic release.	monoamines	102-112	solute carrier family 18 member A2	Homo sapiens	72-77
23658190-5	2013	We found that administration of reserpine, a small-molecule inhibitor of the vesicular monoamine transporter (VMAT) that repackages monoamines into presynaptic vesicles, resulted in an increase in sleep.	monoamines	132-142	Vesicular monoamine transporter	Drosophila melanogaster	77-108
23658190-5	2013	We found that administration of reserpine, a small-molecule inhibitor of the vesicular monoamine transporter (VMAT) that repackages monoamines into presynaptic vesicles, resulted in an increase in sleep.	monoamines	132-142	Vesicular monoamine transporter	Drosophila melanogaster	110-114
23658190-9	2013	Mutations affecting single monoamine pathways did not affect reserpine sensitivity, suggesting that effects of VMAT/reserpine on sleep are mediated by multiple monoamines.	monoamines	160-170	Vesicular monoamine transporter	Drosophila melanogaster	111-115
23530208-1	2013	Vesicular monoamine transporter 2 (VMAT2) catalyzes transport of monoamines into storage vesicles in a process that involves exchange of the charged monoamine with two protons.	monoamines	65-75	solute carrier family 18 member A2	Homo sapiens	0-33
23530208-1	2013	Vesicular monoamine transporter 2 (VMAT2) catalyzes transport of monoamines into storage vesicles in a process that involves exchange of the charged monoamine with two protons.	monoamines	65-75	solute carrier family 18 member A2	Homo sapiens	35-40
23506877-2	2013	Members of the SLC18 family perform this function for acetylcholine (SLC18A3, the vesicular acetylcholine transporter or VAChT) and monoamines such as dopamine and serotonin (SLC18A1 and 2, the vesicular monoamine transporters VMAT1 and 2, respectively).	monoamines	132-142	solute carrier family 18 member A1	Homo sapiens	175-188
23506877-2	2013	Members of the SLC18 family perform this function for acetylcholine (SLC18A3, the vesicular acetylcholine transporter or VAChT) and monoamines such as dopamine and serotonin (SLC18A1 and 2, the vesicular monoamine transporters VMAT1 and 2, respectively).	monoamines	132-142	solute carrier family 18 member A1	Homo sapiens	227-238
22038157-8	2012	TAAR1 is emerging as a potential therapeutic target, with regard to its ability to modulate brain monoamines.	monoamines	98-108	trace amine associated receptor 1	Macaca mulatta	0-5
23190594-8	2013	CONCLUSIONS: Taken together, these results first suggest that the effect of physical activity on the FST is dependent on either the increase in the bioavailability of monoamines in the synaptic cleft or an activation of intracellular signaling pathways mediated by PKA and CAMK-II.	monoamines	167-177	calcium/calmodulin-dependent protein kinase II, beta	Mus musculus	273-280
23018753-3	2013	MAO-A metabolises monoamines, and greater metabolism of monoamines occurs when MAO-A is elevated in brain.	monoamines	18-28	monoamine oxidase A	Homo sapiens	0-5
23018753-3	2013	MAO-A metabolises monoamines, and greater metabolism of monoamines occurs when MAO-A is elevated in brain.	monoamines	56-66	monoamine oxidase A	Homo sapiens	79-84
22361264-14	2012	A better understanding of this may lead to the knowledge of how monoamines influence the orexin system and vice versa.	monoamines	64-74	hypocretin neuropeptide precursor	Rattus norvegicus	89-95
23197705-1	2012	Monoamine oxidase-A (MAO-A), a key brain enzyme which metabolizes monoamines, is implicated in the pathophysiology of stress-related illnesses, including major depressive disorder, addiction, and violent behavior.	monoamines	66-76	monoamine oxidase A	Homo sapiens	0-19
23197705-1	2012	Monoamine oxidase-A (MAO-A), a key brain enzyme which metabolizes monoamines, is implicated in the pathophysiology of stress-related illnesses, including major depressive disorder, addiction, and violent behavior.	monoamines	66-76	monoamine oxidase A	Homo sapiens	21-26
23197705-10	2012	Since MAO-A metabolizes monoamines, this phenomenon may explain why acute stressors benefit healthy animals even though chronic stress is associated with illness.	monoamines	24-34	monoamine oxidase A	Homo sapiens	6-11
22858378-5	2012	All three biogenic monoamines also block TGase-mediated transamidation of another monoamine, monodansylacadaverine, into fibronectin, suggesting a general mechanism of TGase-mediated "monoaminylation".	monoamines	19-29	transglutaminase 1	Homo sapiens	41-46
22858378-5	2012	All three biogenic monoamines also block TGase-mediated transamidation of another monoamine, monodansylacadaverine, into fibronectin, suggesting a general mechanism of TGase-mediated "monoaminylation".	monoamines	19-29	fibronectin 1	Homo sapiens	121-132
22858378-5	2012	All three biogenic monoamines also block TGase-mediated transamidation of another monoamine, monodansylacadaverine, into fibronectin, suggesting a general mechanism of TGase-mediated "monoaminylation".	monoamines	19-29	transglutaminase 1	Homo sapiens	168-173
22698664-1	2012	The vesicular monoamine transporter 2 (VMAT2; Slc18a2) packages monoamines into synaptic vesicles.	monoamines	64-74	solute carrier family 18 member A2	Homo sapiens	4-37
22575564-9	2012	Given the central role for monoamines in ADHD and addiction, it seems likely that the influence of LPHN3 genotype on these disorders is mediated through alterations in monoamine signaling.	monoamines	27-37	adhesion G protein-coupled receptor L3	Mus musculus	99-104
22525891-5	2012	Concomitant data in Drosophila reported that repetitive exposure to nicotine results in a calcium-dependent plasticity of the nAChR-mediated response involving cAMP signaling cascades and indicated that ACh-induced Ca++ currents are modulated by monoamines involved in aversive and appetitive learning.	monoamines	246-256	nicotinic Acetylcholine Receptor beta1	Drosophila melanogaster	126-131
22856363-6	2012	PHOX2B regulates the expression of enzymes necessary for the synthesis of several monoamines and is essential for the development of the autonomic nervous system.	monoamines	82-92	paired like homeobox 2B	Homo sapiens	0-6
22698664-1	2012	The vesicular monoamine transporter 2 (VMAT2; Slc18a2) packages monoamines into synaptic vesicles.	monoamines	64-74	solute carrier family 18 member A2	Homo sapiens	39-44
22698664-1	2012	The vesicular monoamine transporter 2 (VMAT2; Slc18a2) packages monoamines into synaptic vesicles.	monoamines	64-74	solute carrier family 18 member A2	Homo sapiens	46-53
22134693-2	2012	Monoamines seem to play a role in the regulation of BDNF, and monoamine neurotransmission is known to increase with exercise.	monoamines	0-10	brain-derived neurotrophic factor	Rattus norvegicus	52-56
22464880-11	2012	Further, they are markedly elevated by acute stressors, the effects of which are mediated (in contrast to concomitant elevations in levels of monoamines) by co-joint recruitment of CRF(1) and V(1b) receptors.	monoamines	142-152	corticotropin releasing hormone receptor 1	Rattus norvegicus	181-187
22499122-6	2012	Moreover, we have newly identified the two genes that are down-regulated in ESCC: monoamine oxidase A, an enzyme that catalyzes monoamines oxidation and 15-hydroxyprostaglandin dehydrogenase [NAD+], a prostaglandin-synthesizing enzyme that physiologically antagonizes COX-2.	monoamines	128-138	monoamine oxidase A	Homo sapiens	82-101
22507469-0	2012	Detection of plasma and urinary monoamines and their metabolites in nonsegmental vitiligo.	monoamines	32-42	VAMAS6	Homo sapiens	81-89
21636115-3	2011	METHODS: IL-4 production by basophils isolated ex vivo or from bone marrow cultures was assessed in response to various stimuli with or without biogenic monoamines or pharmacologic analogs.	monoamines	153-163	interleukin 4	Mus musculus	9-13
21463543-1	2011	BACKGROUND: Monoamine oxidase A (MAO-A) inhibitor antidepressants raise levels of multiple monoamines, whereas the selective serotonin reuptake inhibitors (SSRIs) only raise extracellular serotonin.	monoamines	91-101	monoamine oxidase A	Homo sapiens	12-31
21463543-1	2011	BACKGROUND: Monoamine oxidase A (MAO-A) inhibitor antidepressants raise levels of multiple monoamines, whereas the selective serotonin reuptake inhibitors (SSRIs) only raise extracellular serotonin.	monoamines	91-101	monoamine oxidase A	Homo sapiens	33-38
22162429-1	2012	Monoamine oxidase A (MAOA) is the enzyme responsible for degradation of several monoamines, such as dopamine and serotonin that are considered as being two of the most important neurotransmitters involved in the pathophysiology of schizophrenia.	monoamines	80-90	monoamine oxidase A	Homo sapiens	0-19
22162429-1	2012	Monoamine oxidase A (MAOA) is the enzyme responsible for degradation of several monoamines, such as dopamine and serotonin that are considered as being two of the most important neurotransmitters involved in the pathophysiology of schizophrenia.	monoamines	80-90	monoamine oxidase A	Homo sapiens	21-25
21814181-1	2011	The vesicular monoamine transporter type 2 gene (VMAT2) has a crucial role in the storage and synaptic release of all monoamines, including serotonin (5-HT).	monoamines	118-128	solute carrier family 18 (vesicular monoamine), member 2	Mus musculus	49-54
21584865-1	2011	Methamphetamine (mAMPH) is an addictive psychostimulant drug that releases monoamines through nonexocytotic mechanisms.	monoamines	75-85	amphiphysin	Mus musculus	17-22
21851116-1	2011	Monoamine oxidase (MAO) A is a flavoenzyme that catalyzes the oxidation of biologically important monoamines and is thought to be associated with psychiatric disorders.	monoamines	98-108	monoamine oxidase A	Homo sapiens	0-25
21487652-1	2011	RATIONALE: Fluvoxamine, a selective serotonin (5-HT) reuptake inhibitor (SSRI) and an agonist for the sigma(1) receptors, increases extracellular monoamines in the prefrontal cortex, but it is not known whether the sigma(1) receptor is involved in the neurochemical effect of fluvoxamine.	monoamines	146-156	sigma non-opioid intracellular receptor 1	Mus musculus	102-119
21669212-1	2011	Tetrabenazine (TBZ), a benzoquinolizine derivative, binds with high affinity to the vesicular monoamine transporter-2 (VMAT2), inhibiting uptake of cytosolic monoamines.	monoamines	158-168	solute carrier family 18 member A2	Rattus norvegicus	84-117
21777907-0	2011	Influence of Neuropeptide Y and antidepressants upon cerebral monoamines involved in depression: an in vivo electrochemical study.	monoamines	62-72	neuropeptide Y	Homo sapiens	13-27
21277567-3	2011	Effects might rely on the influence of inflammation on the activity of two enzymatic pathways, the indoleamine-2,3-dioxygenase (IDO) and the guanosine-triphosphate-cyclohydrolase-1 (GTP-CH1) pathways, which are involved in the biosynthesis of monoamines.	monoamines	243-253	indoleamine 2,3-dioxygenase 1	Homo sapiens	99-126
21277567-3	2011	Effects might rely on the influence of inflammation on the activity of two enzymatic pathways, the indoleamine-2,3-dioxygenase (IDO) and the guanosine-triphosphate-cyclohydrolase-1 (GTP-CH1) pathways, which are involved in the biosynthesis of monoamines.	monoamines	243-253	indoleamine 2,3-dioxygenase 1	Homo sapiens	128-131
21277567-3	2011	Effects might rely on the influence of inflammation on the activity of two enzymatic pathways, the indoleamine-2,3-dioxygenase (IDO) and the guanosine-triphosphate-cyclohydrolase-1 (GTP-CH1) pathways, which are involved in the biosynthesis of monoamines.	monoamines	243-253	GTP cyclohydrolase 1	Homo sapiens	141-180
21277567-3	2011	Effects might rely on the influence of inflammation on the activity of two enzymatic pathways, the indoleamine-2,3-dioxygenase (IDO) and the guanosine-triphosphate-cyclohydrolase-1 (GTP-CH1) pathways, which are involved in the biosynthesis of monoamines.	monoamines	243-253	GTP cyclohydrolase 1	Homo sapiens	182-189
21669212-1	2011	Tetrabenazine (TBZ), a benzoquinolizine derivative, binds with high affinity to the vesicular monoamine transporter-2 (VMAT2), inhibiting uptake of cytosolic monoamines.	monoamines	158-168	solute carrier family 18 member A2	Rattus norvegicus	119-124
21342126-6	2011	Transporters for 5-HT (SERT) and NE (NET) are also expressed at the apical surface and regulate extracellular concentrations of monoamines.	monoamines	128-138	solute carrier family 6 member 4	Homo sapiens	23-27
21609470-5	2011	RESULTS: Using high performance liquid chromatography, combined with electrochemical detection (HPLC/EC) we found that Mecp2(-/y) mice exhibit an alteration of DA metabolism in the ponto-bulbar region at 5 weeks followed by a more global alteration of monoamines when the disease progresses (8 weeks).	monoamines	252-262	methyl CpG binding protein 2	Mus musculus	119-124
20943434-6	2011	CONCLUSION: Both L-DOPA and STN-HFS influence the metabolism of monoamines in the midbrain, and restore the descending neuromodulation on group II spinal reflex.	monoamines	64-74	eukaryotic translation elongation factor 1 alpha 2	Homo sapiens	28-31
20858707-6	2010	In contrast, hOCT3 is less selective than hPMAT toward the monoamines, and the V(max)/K(m) rank order for hOCT3 is: histamine > norepinephrine, epinephrine > dopamine >5-HT.	monoamines	59-69	solute carrier family 22 member 3	Homo sapiens	13-18
20810002-1	2011	BACKGROUND: Monoamine oxidase A (MAOA) is an important enzyme that metabolizes monoamines such as serotonin, norepinephrine and dopamine in the brain.	monoamines	79-89	monoamine oxidase A	Homo sapiens	12-31
20810002-1	2011	BACKGROUND: Monoamine oxidase A (MAOA) is an important enzyme that metabolizes monoamines such as serotonin, norepinephrine and dopamine in the brain.	monoamines	79-89	monoamine oxidase A	Homo sapiens	33-37
21385602-2	2011	This increase is believed to originate from the brain and it is suggested that monoamines are involved in BDNF regulation.	monoamines	79-89	brain derived neurotrophic factor	Homo sapiens	106-110
21079379-2	2011	Because monoamine oxidase-A (MAO-A) is a potent degrading enzyme of these monoamines, we hypothesized that orexin-A may mediate its arousal-inducing effects through MAO-A.	monoamines	74-84	monoamine oxidase A	Homo sapiens	8-27
21079379-2	2011	Because monoamine oxidase-A (MAO-A) is a potent degrading enzyme of these monoamines, we hypothesized that orexin-A may mediate its arousal-inducing effects through MAO-A.	monoamines	74-84	monoamine oxidase A	Homo sapiens	29-34
21143600-10	2011	By elucidating the mechanisms by which NE and beta1-adrenergic receptor activation affects striatal physiology, we provide the means to more fully understand the role of monoamines in modulating striatal function, specifically how NE and beta1-adrenergic receptors may affect striatal physiology.	monoamines	170-180	adrenoceptor beta 1	Homo sapiens	46-71
21196154-2	2011	Insulin secretion is regulated by sympathetic and parasympathetic nervous systems and modulates the concentrations of hypothalamic neuropeptides and monoaminergic neurotransmitters, and, in return, hypothalamic monoamines regulate the secretion of insulin by pancreatic beta cells.	monoamines	211-221	insulin	Homo sapiens	0-7
21073468-1	2011	It is now recognized that trace amine associated-receptor 1 (TAAR1) plays a functional role in the regulation of brain monoamines and the mediation of action of amphetamine-like psychostimulants.	monoamines	119-129	trace amine associated receptor 1	Homo sapiens	26-59
21073468-1	2011	It is now recognized that trace amine associated-receptor 1 (TAAR1) plays a functional role in the regulation of brain monoamines and the mediation of action of amphetamine-like psychostimulants.	monoamines	119-129	trace amine associated receptor 1	Homo sapiens	61-66
21073468-2	2011	Accordingly, research on TAAR1 opens the door to a new avenue of approach for medications development to treat drug addiction as well as the spectrum of neuropsychiatric disorders hallmarked by aberrant regulation of brain monoamines.	monoamines	223-233	trace amine associated receptor 1	Homo sapiens	25-30
21365590-8	2011	CONCLUSION: Since dopamine and other monoamines (epinephrine and serotonine) play a role in ADHD, and methylphenidate, an usual treatment for this type of patients, modifies the VMAT2 activity, we may argue that VMAT2 is involved in ADHD pathogeny.	monoamines	37-47	solute carrier family 18 member A2	Homo sapiens	178-183
21456501-7	2011	Concerning monoamines in urine, we have observed significantly increased serotonin levels in HDC group compared to control (p < 0.05) and LDC animals (p < 0.01).	monoamines	11-21	histidine decarboxylase	Rattus norvegicus	93-96
20858707-7	2010	It is noteworthy that hOCT3 demonstrated comparable (<=2-fold difference) K(m) toward all amines, and distinctions in V(max) played an important role in determining its differential transport efficiency toward the monoamines.	monoamines	217-227	solute carrier family 22 member 3	Homo sapiens	22-27
20828630-0	2010	Estradiol and ERbeta agonists enhance recognition memory, and DPN, an ERbeta agonist, alters brain monoamines.	monoamines	99-109	estrogen receptor 2	Rattus norvegicus	70-76
20859243-1	2010	OBJECTIVES: The goals of this study were to determine the role of organic cation transporter 3 (OCT3) in the pharmacological action of metformin and to identify and functionally characterize genetic variants of OCT3 with respect to the uptake of metformin and monoamines.	monoamines	260-270	OCTN3	Homo sapiens	211-215
20633611-3	2010	A deregulation of monoamines has been detected in the brain and cerebrospinal fluid of both Rett patients and a Rett syndrome murine model, the Mecp2 knock-out mouse.	monoamines	18-28	methyl CpG binding protein 2	Mus musculus	144-149
23875515-4	2010	We tested the hypothesis that denynium22 may compete with monoamines utilizing OCT to permeate the cells.	monoamines	58-68	plexin A2	Homo sapiens	79-82
20181938-1	2010	SLC18A2 encodes the vesicular monoamine transporter 2 protein that regulates neurotransmission and reduces cytosolic toxicity of monoamines.	monoamines	129-139	solute carrier family 18 member A2	Homo sapiens	0-7
19854260-8	2010	Neurotransmitter-induced NT-3 levels were susceptible (to varying degrees) to inhibition by H-89 (protein kinase A inhibitor) or staurosporin (protein kinase C inhibitor), which led us to conclude that downstream signaling responsible for the stimulation of NT-3 synthesis by monoamines in astrocytes consists of multiple, complex intracellular mechanisms involving the cAMP/protein kinase A pathway, activation of protein kinase C, as well as mobilization of Ca(2+) ions.	monoamines	276-286	neurotrophin 3	Rattus norvegicus	25-29
20188885-3	2010	Surprisingly, ECL intensities of monoamines, such as 2-(dibutylamino)ethanol and N-butyldiethanolamine, are much stronger than that of diamines including N,N,N",N"-tetrakis-(2-hydroxyethyl)-ethylenediamine and N,N,N",N"-tetrakis-(2-hydroxypropyl)ethlenediamine.	monoamines	33-43	C-C motif chemokine ligand 21	Homo sapiens	14-17
20188885-4	2010	The striking contrast between ECL signals of the investigated monoamines and diamines may result from more significant side reactions of diamines, such as the intramolecular side reactions between oxidative amine cation radicals and reductive amine free radicals.	monoamines	62-72	C-C motif chemokine ligand 21	Homo sapiens	30-33
19932741-4	2010	In this study, we measured levels of monoamines by high-performance liquid chromatography with electrochemical detection in selected regions of the forebrains of Mecp2-null mice (Mecp2-/y) and wild-type mice (Mecp2+/y) on postnatal day (P) 14, P28, P42 and P56.	monoamines	37-47	methyl CpG binding protein 2	Mus musculus	162-167
20007701-1	2010	The vesicular neurotransmitter transporter VMAT2 is responsible for the transport of monoamines into synaptic and storage vesicles.	monoamines	85-95	solute carrier family 18 member A2	Rattus norvegicus	43-48
19903816-2	2010	In the brain, the vesicular monoamine transporter-2 (VMAT(2)) is responsible for the loading of dopamine (DA) and other monoamines into synaptic vesicles.	monoamines	120-130	solute carrier family 18 member A2	Rattus norvegicus	18-51
19903816-2	2010	In the brain, the vesicular monoamine transporter-2 (VMAT(2)) is responsible for the loading of dopamine (DA) and other monoamines into synaptic vesicles.	monoamines	120-130	solute carrier family 18 member A2	Rattus norvegicus	53-60
20146381-8	2010	Adrenal hypertrophy and steroidogenic arrest of the adrenal gland along with altered level of brain monoamines in the midbrain and diencephalons following arsenic intoxication were also ameliorated after hCG coadministration.	monoamines	100-110	chorionic gonadotropin subunit beta 5	Homo sapiens	204-207
19588076-4	2009	Molecular modeling suggested structural differences between AOC2 and AOC3, which provide AOC2 with the capability to use the larger monoamines as substrates.	monoamines	132-142	amine oxidase copper containing 2	Homo sapiens	60-64
19725810-0	2009	Human and mouse trace amine-associated receptor 1 have distinct pharmacology towards endogenous monoamines and imidazoline receptor ligands.	monoamines	96-106	trace amine-associated receptor 1	Mus musculus	16-49
19691856-1	2009	BACKGROUND: Monoamine oxidase A (MAO-A), a mitochondrial enzyme that degrades monoamines including neurotransmitters, is highly expressed in basal cells of the normal human prostatic epithelium and in poorly differentiated (Gleason grades 4 and 5), aggressive prostate cancer (PCa).	monoamines	78-88	monoamine oxidase A	Homo sapiens	12-31
19691856-1	2009	BACKGROUND: Monoamine oxidase A (MAO-A), a mitochondrial enzyme that degrades monoamines including neurotransmitters, is highly expressed in basal cells of the normal human prostatic epithelium and in poorly differentiated (Gleason grades 4 and 5), aggressive prostate cancer (PCa).	monoamines	78-88	monoamine oxidase A	Homo sapiens	33-38
19588076-4	2009	Molecular modeling suggested structural differences between AOC2 and AOC3, which provide AOC2 with the capability to use the larger monoamines as substrates.	monoamines	132-142	amine oxidase copper containing 3	Homo sapiens	69-73
19588076-4	2009	Molecular modeling suggested structural differences between AOC2 and AOC3, which provide AOC2 with the capability to use the larger monoamines as substrates.	monoamines	132-142	amine oxidase copper containing 2	Homo sapiens	89-93
19457116-2	2009	The vesicular monoamine transporter-2 (VMAT2) is essential for loading monoamines into vesicles and maintaining normal neurotransmission.	monoamines	71-81	solute carrier family 18 member A2	Homo sapiens	4-37
19457116-2	2009	The vesicular monoamine transporter-2 (VMAT2) is essential for loading monoamines into vesicles and maintaining normal neurotransmission.	monoamines	71-81	solute carrier family 18 member A2	Homo sapiens	39-44
19118592-5	2009	Similar dose regimen was then used to measure ghrelin-induced effects on extracellular levels of monoamines in the shell and core subdivisions of the NAc using microdialysis in freely moving rats.	monoamines	97-107	ghrelin and obestatin prepropeptide	Rattus norvegicus	46-53
19194374-10	2009	Monoamines such as noradrenalin and serotonin may modulate these relationships, given that their metabolism varies according to MAOA variants, and that they modulate both emotional brain systems and antisocial aggression.	monoamines	0-10	monoamine oxidase A	Homo sapiens	128-132
19025979-6	2009	The widespread distribution of OCT3-ir cell bodies, including regions receiving dense monoaminergic projections, suggests an important role for this transporter in regulating extracellular concentrations of monoamines in the rat brain and is consistent with the hypothesis that corticosterone-induced inhibition of OCT3-mediated transport may contribute to effects of acute stress or corticosterone on monoaminergic neurotransmission.	monoamines	207-217	solute carrier family 22 member 3	Rattus norvegicus	31-35